@precisa-saude/fhir 0.15.0 → 0.15.2

package/dist/cli.js

@@ -158,9 +158,13 @@ var BIOMARKER_DEFINITIONS = [
     unit: "nmol/L"
   },
   {
+    // LOINC 43583-4 = "Lipoprotein a [Moles/volume] in Serum or Plasma" (nmol/L).
+    // Anteriormente 10835-7 ("Lipoprotein a [Mass/volume]", mg/dL),
+    // incompatível com a unidade nmol/L declarada. SBC 2025 recomenda
+    // ensaio independente de isoforma reportado em nmol/L.
     category: "coracao",
     code: "Lipoprotein_a",
-    loinc: "10835-7",
+    loinc: "43583-4",
     names: {
       en: ["Lipoprotein (a)", "Lp(a)"],
       pt: ["Lipoprote\xEDna (a)", "Lp(a)"]
@@ -1006,9 +1010,18 @@ var BIOMARKER_DEFINITIONS = [
     unit: "nmol/L"
   },
   {
+    // LOINC 99620-7 = "Omega 3 fatty acids (w3) [Moles/volume] in RBC.lysate".
+    // Alinha à matriz das entradas irmãs Omega3_EPA (75097-6) e Omega3_DHA
+    // (75095-0), ambas em hemácias. Anteriormente 35178-3 (mesmo analito em
+    // Ser/Plas), incompatível com o uso clínico do Índice Ômega-3 (Harris &
+    // von Schacky 2004), que é definido em membranas de hemácias.
+    // Ressalva: LOINC declara moles/volume; o biomarcador armazena %.
+    // Não há LOINC vigente para "Omega 3 total em % em RBC" — o `Omega3_Index`
+    // (88998-0) cobre apenas EPA+DHA. Mantemos `unit: '%'` por consistência
+    // com EPA/DHA (75095-0/75097-6 são [Entitic substance], também não-%).
     category: "nutrientes",
     code: "Omega3_Total",
-    loinc: "35178-3",
+    loinc: "99620-7",
     names: {
       en: ["Omega-3 Total", "Total Omega-3"],
       pt: ["\xD4mega-3 Total"]
@@ -1480,11 +1493,16 @@ var BIOMARKER_DEFINITIONS = [
     unit: "mg/L"
   },
   {
+    // LOINC 3091-6 = "Urea [Mass/volume] in Serum or Plasma" (mg/dL).
+    // Anteriormente 3094-0 ("Urea nitrogen", BUN), inconsistente com a faixa
+    // de referência brasileira (15-50 mg/dL) e com os nomes pt-BR (Ureia).
+    // Aliases 'BUN' e 'Blood Urea Nitrogen' removidos para evitar matching
+    // de relatórios de BUN contra faixas de Ureia (BUN ≈ Ureia / 2,14).
     category: "rins",
     code: "Urea",
-    loinc: "3094-0",
+    loinc: "3091-6",
     names: {
-      en: ["Blood Urea Nitrogen", "BUN", "Urea"],
+      en: ["Urea"],
       pt: ["Ureia", "Ur\xE9ia"]
     },
     unit: "mg/dL"
@@ -4180,8 +4198,14 @@ var biomarkerRangeDefinitions = {
       }
     ]
   },
+  // AMH — fortemente dependente de idade e sexo. As variantes femininas por
+  // faixa etária são a referência clínica; o `default` foi ajustado para
+  // refletir uma faixa adulta conservadora (~18-40 anos, mulheres em idade
+  // reprodutiva geral). optimalMax anterior (6.9 ng/mL) sobrepunha-se a
+  // valores sugestivos de SOP ou risco de OHSS; clinicamente, valores acima
+  // de ~4 ng/mL já merecem investigação.
   AMH: {
-    default: { max: 10, min: 1, optimalMax: 6.9, optimalMin: 2, unit: "ng/mL" },
+    default: { max: 6, min: 1, optimalMax: 4, optimalMin: 1.5, unit: "ng/mL" },
     source: "tietz-7ed-2015",
     variants: [
       {
@@ -4319,6 +4343,12 @@ var biomarkerRangeDefinitions = {
     default: { max: 35, min: 0, optimalMax: 20, optimalMin: 0, unit: "pg/mL" },
     source: "sbc-ic-2018"
   },
+  // Razão BUN/Creatinina — faixa 10-20 aplica-se ao Nitrogênio Ureico (BUN).
+  // Laboratórios brasileiros que reportam Ureia (e não BUN) usam razão
+  // Ureia/Creatinina, cuja faixa normal é aproximadamente 21-43
+  // (Ureia ≈ BUN × 2,14). O biomarcador atualmente assume a convenção BUN;
+  // consumidores que dosem Ureia devem converter ou reportar como razão
+  // distinta. Ver issue #41 para alinhamento de nomenclatura/LOINC.
   BUN_Creatinine_Ratio: {
     default: { max: 20, min: 10, optimalMax: 18, optimalMin: 12, unit: "" },
     source: "tietz-7ed-2015"
@@ -4388,8 +4418,11 @@ var biomarkerRangeDefinitions = {
     default: { max: 106, min: 98, optimalMax: 105, optimalMin: 100, unit: "mEq/L" },
     source: "tietz-7ed-2015"
   },
+  // Colesterol total — SBC 2017/2025: valor desejável < 190 mg/dL para adultos,
+  // com ou sem jejum. Limite anterior (200 mg/dL) refletia a diretriz ATP III
+  // (NCEP, 2002), superada pelas atualizações brasileiras.
   Cholesterol: {
-    default: { max: 200, min: 0, optimalMax: 180, optimalMin: 0, unit: "mg/dL" },
+    default: { max: 190, min: 0, optimalMax: 170, optimalMin: 0, unit: "mg/dL" },
     source: "sbc-lipids-2025"
   },
   // Índice de Castelli I (CT/HDL-c)
@@ -4745,19 +4778,25 @@ var biomarkerRangeDefinitions = {
       }
     ]
   },
+  // HDL — SBC 2017/2025: desejável > 40 mg/dL (♂) e > 50 mg/dL (♀).
+  // A diretriz NÃO define teto de normalidade — HDL alto é cardioprotetor.
+  // Limites superiores anteriormente fixados em 60 mg/dL geravam falsos
+  // alertas. Mantém-se `max` apenas como limite técnico do gauge (100 mg/dL),
+  // não como ponto de corte clínico; consumidores devem tratar `direction:
+  // higher-better` como sinal autoritativo.
   HDL: {
-    default: { max: 60, min: 40, optimalMax: 60, optimalMin: 50, unit: "mg/dL" },
+    default: { max: 100, min: 40, optimalMax: 100, optimalMin: 50, unit: "mg/dL" },
     direction: "higher-better",
     source: "sbc-lipids-2025",
     variants: [
       {
         ageMin: 18,
-        range: { max: 60, min: 40, optimalMax: 60, optimalMin: 45, unit: "mg/dL" },
+        range: { max: 100, min: 40, optimalMax: 100, optimalMin: 45, unit: "mg/dL" },
         sex: "M"
       },
       {
         ageMin: 18,
-        range: { max: 60, min: 50, optimalMax: 60, optimalMin: 55, unit: "mg/dL" },
+        range: { max: 100, min: 50, optimalMax: 100, optimalMin: 55, unit: "mg/dL" },
         sex: "F"
       }
     ]
@@ -4974,8 +5013,14 @@ var biomarkerRangeDefinitions = {
     default: { max: 35, min: 15, optimalMax: 28, optimalMin: 18, unit: "%" },
     source: "simopoulos-omega-ratio-2002"
   },
+  // Lp(a) — SBC 2025 (seção 3.1.1.2.7): níveis ≥ 50 mg/dL ou ≥ 125 nmol/L são
+  // considerados aumentados, com indicação de rastreamento em cascata familiar.
+  // A diretriz recomenda ensaio independente de isoforma medido em nmol/L; a
+  // unidade nmol/L é mantida aqui por refletir o padrão laboratorial atual.
+  // Limites anteriores (max=75) refletiam pontos de corte expressos em mg/dL,
+  // gerando incompatibilidade com a unidade nmol/L declarada.
   Lipoprotein_a: {
-    default: { max: 75, min: 0, optimalMax: 30, optimalMin: 0, unit: "nmol/L" },
+    default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "nmol/L" },
     direction: "lower-better",
     source: "sbc-lipids-2025"
   },
@@ -5067,8 +5112,13 @@ var biomarkerRangeDefinitions = {
     default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" },
     source: "harris-omega3-2004"
   },
+  // Ômega-3 Total (% de ácidos graxos eritrocitários) — Harris & von Schacky
+  // (2004) propõem ≥ 8% como zona ótima de proteção cardiovascular; valores
+  // entre 4% e 8% representam risco intermediário, < 4% risco alto.
+  // optimalMin anterior (5.5%) ficava em zona intermediária, contradizendo
+  // a literatura e o próprio texto educacional do `platform`.
   Omega3_Total: {
-    default: { max: 12, min: 3, optimalMax: 10, optimalMin: 5.5, unit: "%" },
+    default: { max: 12, min: 3, optimalMax: 10, optimalMin: 8, unit: "%" },
     source: "harris-omega3-2004"
   },
   Omega6_Total: {
@@ -5104,9 +5154,37 @@ var biomarkerRangeDefinitions = {
     default: { max: 38, min: 18, optimalMax: 35, optimalMin: 20, unit: "mg/dL" },
     source: "tietz-7ed-2015"
   },
+  // Progesterona — varia drasticamente com a fase do ciclo menstrual.
+  // O schema atual não modela fase do ciclo, então adotamos faixas amplas
+  // por sexo: o `default` cobre homens/fase folicular/pós-menopausa; a
+  // variante feminina expande até a faixa esperada de fase lútea
+  // (~3-20 ng/mL). Interpretação correta exige correlação com a fase do
+  // ciclo, indisponível neste contexto.
   Progesterone: {
     default: { max: 0.9, min: 0.1, optimalMax: 0.7, optimalMin: 0.2, unit: "ng/mL" },
-    source: "tietz-7ed-2015"
+    source: "tietz-7ed-2015",
+    variants: [
+      {
+        ageMin: 18,
+        range: { max: 0.9, min: 0.1, optimalMax: 0.6, optimalMin: 0.2, unit: "ng/mL" },
+        sex: "M"
+      },
+      // Mulheres em idade reprodutiva: faixa que abarca fases folicular
+      // (0.1-0.9 ng/mL) e lútea (3-20 ng/mL). Sem contexto de fase do ciclo,
+      // valores intermediários (1-3 ng/mL) ficam em zona ambígua.
+      {
+        ageMax: 50,
+        ageMin: 18,
+        range: { max: 20, min: 0.1, optimalMax: 15, optimalMin: 0.2, unit: "ng/mL" },
+        sex: "F"
+      },
+      // Pós-menopausa: valores tipicamente < 0.5 ng/mL (sem ovulação).
+      {
+        ageMin: 51,
+        range: { max: 0.5, min: 0, optimalMax: 0.3, optimalMin: 0, unit: "ng/mL" },
+        sex: "F"
+      }
+    ]
   },
   Prolactin: {
     default: { max: 18, min: 2, optimalMax: 15, optimalMin: 4, unit: "ng/mL" },
@@ -5384,8 +5462,13 @@ var biomarkerRangeDefinitions = {
       }
     ]
   },
+  // Ureia — convenção brasileira (laboratórios reportam Ureia, não BUN).
+  // Faixa adulta de 15-50 mg/dL (Ureia ≈ BUN × 2,14). Limites anteriores
+  // (7-20 mg/dL) refletiam BUN/Nitrogênio Ureico, gerando falsos diagnósticos
+  // de azotemia em pacientes com Ureia normal. LOINC 3094-0 (BUN) também
+  // deve ser revisto em biomarkers.ts — ver issue #41.
   Urea: {
-    default: { max: 20, min: 7, optimalMax: 16, optimalMin: 10, unit: "mg/dL" },
+    default: { max: 50, min: 15, optimalMax: 40, optimalMin: 20, unit: "mg/dL" },
     source: "tietz-7ed-2015"
   },
   UricAcid: {
@@ -6029,7 +6112,7 @@ async function main() {
     strict: false
   });
   if (values.version) {
-    process.stdout.write(`${"0.15.0"}
+    process.stdout.write(`${"0.15.2"}
 `);
     return;
   }

package/dist/converter.cjs

@@ -3,13 +3,13 @@
 
 
 
-var _chunkOPS7XHILcjs = require('./chunk-OPS7XHIL.cjs');
-require('./chunk-EW5GLFSC.cjs');
+var _chunkQ3O23BM7cjs = require('./chunk-Q3O23BM7.cjs');
+require('./chunk-3NZA6WMU.cjs');
 require('./chunk-MJ254F5K.cjs');
 
 
 
 
 
-exports.labObservationToFHIR = _chunkOPS7XHILcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkOPS7XHILcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkOPS7XHILcjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkOPS7XHILcjs.userProfileToFHIR;
+exports.labObservationToFHIR = _chunkQ3O23BM7cjs.labObservationToFHIR; exports.labReportToFHIR = _chunkQ3O23BM7cjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkQ3O23BM7cjs.labResultToFHIRBundle; exports.userProfileToFHIR = _chunkQ3O23BM7cjs.userProfileToFHIR;
 //# sourceMappingURL=converter.cjs.map

package/dist/converter.js

@@ -3,8 +3,8 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-NR4OTNC4.js";
-import "./chunk-ICSMWCVT.js";
+} from "./chunk-5BDMX2JP.js";
+import "./chunk-FEVGNEFO.js";
 import "./chunk-R4MUCMO3.js";
 export {
   labObservationToFHIR,

package/dist/importer.cjs

@@ -4,8 +4,8 @@
 
 
 
-var _chunkNOJRDKFOcjs = require('./chunk-NOJRDKFO.cjs');
-require('./chunk-EW5GLFSC.cjs');
+var _chunkY2SVZ6GEcjs = require('./chunk-Y2SVZ6GE.cjs');
+require('./chunk-3NZA6WMU.cjs');
 require('./chunk-3ILBFLVQ.cjs');
 
 
@@ -13,5 +13,5 @@ require('./chunk-3ILBFLVQ.cjs');
 
 
 
-exports.MAX_FILE_SIZE = _chunkNOJRDKFOcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkNOJRDKFOcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunkNOJRDKFOcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunkNOJRDKFOcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunkNOJRDKFOcjs.processImportBundle;
+exports.MAX_FILE_SIZE = _chunkY2SVZ6GEcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkY2SVZ6GEcjs.MAX_OBSERVATIONS; exports.extractObservationsFromBundle = _chunkY2SVZ6GEcjs.extractObservationsFromBundle; exports.mapFHIRObservationToInternal = _chunkY2SVZ6GEcjs.mapFHIRObservationToInternal; exports.processImportBundle = _chunkY2SVZ6GEcjs.processImportBundle;
 //# sourceMappingURL=importer.cjs.map

package/dist/importer.js

@@ -4,8 +4,8 @@ import {
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-4YQOKZX7.js";
-import "./chunk-ICSMWCVT.js";
+} from "./chunk-4I5G4SJ6.js";
+import "./chunk-FEVGNEFO.js";
 import "./chunk-N3ZCOLG2.js";
 export {
   MAX_FILE_SIZE,

package/dist/index.cjs

@@ -3,14 +3,14 @@
 
 
 
-var _chunkOPS7XHILcjs = require('./chunk-OPS7XHIL.cjs');
+var _chunkQ3O23BM7cjs = require('./chunk-Q3O23BM7.cjs');
 
 
 
 
 
 
-var _chunkNOJRDKFOcjs = require('./chunk-NOJRDKFO.cjs');
+var _chunkY2SVZ6GEcjs = require('./chunk-Y2SVZ6GE.cjs');
 
 
 
@@ -43,7 +43,7 @@ var _chunkNOJRDKFOcjs = require('./chunk-NOJRDKFO.cjs');
 
 
 
-var _chunkEW5GLFSCcjs = require('./chunk-EW5GLFSC.cjs');
+var _chunk3NZA6WMUcjs = require('./chunk-3NZA6WMU.cjs');
 
 
 
@@ -51,7 +51,7 @@ var _chunkEW5GLFSCcjs = require('./chunk-EW5GLFSC.cjs');
 
 
 
-var _chunk3IOAP7CGcjs = require('./chunk-3IOAP7CG.cjs');
+var _chunkZKN5UI7Rcjs = require('./chunk-ZKN5UI7R.cjs');
 
 
 
@@ -228,7 +228,7 @@ function interventionToFHIRObservation(intervention, patientId) {
 }
 function interventionsToFHIRBundle(interventions, userProfile) {
   const patientId = userProfile.userId;
-  const fhirPatient = _chunkOPS7XHILcjs.userProfileToFHIR.call(void 0, userProfile);
+  const fhirPatient = _chunkQ3O23BM7cjs.userProfileToFHIR.call(void 0, userProfile);
   const entries = interventions.map((intervention) => {
     const isMedication = intervention.type === "medication" || intervention.type === "supplement";
     const resource = isMedication ? interventionToFHIRMedicationStatement(intervention, patientId) : interventionToFHIRObservation(intervention, patientId);
@@ -691,5 +691,5 @@ function cnsToFHIRIdentifier(cns) {
 
 
 
-exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_DEFAULT_UNIT = _chunkMJ254F5Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunkEW5GLFSCcjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkMJ254F5Kcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.CAC_INDICATOR_CODES = _chunkEW5GLFSCcjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunkEW5GLFSCcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunkEW5GLFSCcjs.DEXA_INDICATOR_CODES; exports.MAX_FILE_SIZE = _chunkNOJRDKFOcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkNOJRDKFOcjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkMJ254F5Kcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunk3IOAP7CGcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunk3IOAP7CGcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunkEW5GLFSCcjs.codeToLoinc; exports.convertUnit = _chunkMJ254F5Kcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunk3IOAP7CGcjs.defaultReferenceRanges; exports.extractObservationsFromBundle = _chunkNOJRDKFOcjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunkEW5GLFSCcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunkEW5GLFSCcjs.findCodeByName; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunkEW5GLFSCcjs.generateCacFullReference; exports.generateDexaFullReference = _chunkEW5GLFSCcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunkEW5GLFSCcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunkEW5GLFSCcjs.generateLLMReference; exports.getAllCodes = _chunkEW5GLFSCcjs.getAllCodes; exports.getAllDefinitions = _chunkEW5GLFSCcjs.getAllDefinitions; exports.getAllLoincCodes = _chunkEW5GLFSCcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunkEW5GLFSCcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunkEW5GLFSCcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunkEW5GLFSCcjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkMJ254F5Kcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkMJ254F5Kcjs.getDefaultUnit; exports.getDefinitionByCode = _chunkEW5GLFSCcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunkEW5GLFSCcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunkEW5GLFSCcjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunk3IOAP7CGcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunk3IOAP7CGcjs.getRangeDirection; exports.getReferenceRange = _chunk3IOAP7CGcjs.getReferenceRange; exports.getSIUnit = _chunkMJ254F5Kcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunkEW5GLFSCcjs.getSexForCode; exports.getVisibleDefinitions = _chunkEW5GLFSCcjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunkEW5GLFSCcjs.isBiomarkerVisible; exports.isCacDocument = _chunkEW5GLFSCcjs.isCacDocument; exports.isDexaDocument = _chunkEW5GLFSCcjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunkEW5GLFSCcjs.isValidCode; exports.isValidLoinc = _chunkEW5GLFSCcjs.isValidLoinc; exports.labObservationToFHIR = _chunkOPS7XHILcjs.labObservationToFHIR; exports.labReportToFHIR = _chunkOPS7XHILcjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkOPS7XHILcjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunkEW5GLFSCcjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkNOJRDKFOcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunkEW5GLFSCcjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkNOJRDKFOcjs.processImportBundle; exports.toBiomarkerTests = _chunkEW5GLFSCcjs.toBiomarkerTests; exports.unitToUCUM = _chunkMJ254F5Kcjs.unitToUCUM; exports.userProfileToFHIR = _chunkOPS7XHILcjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunkEW5GLFSCcjs.validateLoincNameMatch;
+exports.AGE_BRACKETS = AGE_BRACKETS; exports.BIOMARKER_DEFAULT_UNIT = _chunkMJ254F5Kcjs.BIOMARKER_DEFAULT_UNIT; exports.BIOMARKER_DEFINITIONS = _chunk3NZA6WMUcjs.BIOMARKER_DEFINITIONS; exports.BIOMARKER_UNITS = _chunkMJ254F5Kcjs.BIOMARKER_UNITS; exports.BODY_FAT_ZONES = BODY_FAT_ZONES; exports.CAC_INDICATOR_CODES = _chunk3NZA6WMUcjs.CAC_INDICATOR_CODES; exports.CATEGORY_GROUPS = CATEGORY_GROUPS; exports.CATEGORY_SCREENING_INTERVALS = CATEGORY_SCREENING_INTERVALS; exports.DEXA_CATEGORIES = _chunk3NZA6WMUcjs.DEXA_CATEGORIES; exports.DEXA_INDICATOR_CODES = _chunk3NZA6WMUcjs.DEXA_INDICATOR_CODES; exports.MAX_FILE_SIZE = _chunkY2SVZ6GEcjs.MAX_FILE_SIZE; exports.MAX_OBSERVATIONS = _chunkY2SVZ6GEcjs.MAX_OBSERVATIONS; exports.T_SCORE_ZONES = T_SCORE_ZONES; exports.UNIT_TO_UCUM = _chunkMJ254F5Kcjs.UNIT_TO_UCUM; exports.ZONE_DEFS = ZONE_DEFS; exports.applyFallbackReferenceRanges = _chunkZKN5UI7Rcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkZKN5UI7Rcjs.biomarkerRangeDefinitions; exports.calculateNextScreeningDate = calculateNextScreeningDate; exports.cnsToFHIRIdentifier = cnsToFHIRIdentifier; exports.codeToLoinc = _chunk3NZA6WMUcjs.codeToLoinc; exports.convertUnit = _chunkMJ254F5Kcjs.convertUnit; exports.cpfToFHIRIdentifier = cpfToFHIRIdentifier; exports.defaultReferenceRanges = _chunkZKN5UI7Rcjs.defaultReferenceRanges; exports.extractObservationsFromBundle = _chunkY2SVZ6GEcjs.extractObservationsFromBundle; exports.filterVisibleBiomarkers = _chunk3NZA6WMUcjs.filterVisibleBiomarkers; exports.findCodeByName = _chunk3NZA6WMUcjs.findCodeByName; exports.formatCNS = formatCNS; exports.formatCPF = formatCPF; exports.generateCacFullReference = _chunk3NZA6WMUcjs.generateCacFullReference; exports.generateDexaFullReference = _chunk3NZA6WMUcjs.generateDexaFullReference; exports.generateFilteredLLMReference = _chunk3NZA6WMUcjs.generateFilteredLLMReference; exports.generateLLMReference = _chunk3NZA6WMUcjs.generateLLMReference; exports.getAllCodes = _chunk3NZA6WMUcjs.getAllCodes; exports.getAllDefinitions = _chunk3NZA6WMUcjs.getAllDefinitions; exports.getAllLoincCodes = _chunk3NZA6WMUcjs.getAllLoincCodes; exports.getAllSearchPatterns = _chunk3NZA6WMUcjs.getAllSearchPatterns; exports.getBiomarkersByCategory = _chunk3NZA6WMUcjs.getBiomarkersByCategory; exports.getBiomarkersForCategories = _chunk3NZA6WMUcjs.getBiomarkersForCategories; exports.getCanonicalUnit = _chunkMJ254F5Kcjs.getCanonicalUnit; exports.getCategoriesByInterval = getCategoriesByInterval; exports.getCategoryGroup = getCategoryGroup; exports.getDaysUntilScreening = getDaysUntilScreening; exports.getDefaultUnit = _chunkMJ254F5Kcjs.getDefaultUnit; exports.getDefinitionByCode = _chunk3NZA6WMUcjs.getDefinitionByCode; exports.getDefinitionByLoinc = _chunk3NZA6WMUcjs.getDefinitionByLoinc; exports.getDefinitionsBySex = _chunk3NZA6WMUcjs.getDefinitionsBySex; exports.getDueCategories = getDueCategories; exports.getFallbackReferenceRange = _chunkZKN5UI7Rcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkZKN5UI7Rcjs.getRangeDirection; exports.getReferenceRange = _chunkZKN5UI7Rcjs.getReferenceRange; exports.getSIUnit = _chunkMJ254F5Kcjs.getSIUnit; exports.getScreeningInterval = getScreeningInterval; exports.getSexForCode = _chunk3NZA6WMUcjs.getSexForCode; exports.getVisibleDefinitions = _chunk3NZA6WMUcjs.getVisibleDefinitions; exports.interventionToFHIRMedicationStatement = interventionToFHIRMedicationStatement; exports.interventionToFHIRObservation = interventionToFHIRObservation; exports.interventionsToFHIRBundle = interventionsToFHIRBundle; exports.isBiomarkerVisible = _chunk3NZA6WMUcjs.isBiomarkerVisible; exports.isCacDocument = _chunk3NZA6WMUcjs.isCacDocument; exports.isDexaDocument = _chunk3NZA6WMUcjs.isDexaDocument; exports.isScreeningDue = isScreeningDue; exports.isValidCode = _chunk3NZA6WMUcjs.isValidCode; exports.isValidLoinc = _chunk3NZA6WMUcjs.isValidLoinc; exports.labObservationToFHIR = _chunkQ3O23BM7cjs.labObservationToFHIR; exports.labReportToFHIR = _chunkQ3O23BM7cjs.labReportToFHIR; exports.labResultToFHIRBundle = _chunkQ3O23BM7cjs.labResultToFHIRBundle; exports.listMappedSubcategories = listMappedSubcategories; exports.loincToCode = _chunk3NZA6WMUcjs.loincToCode; exports.mapFHIRObservationToInternal = _chunkY2SVZ6GEcjs.mapFHIRObservationToInternal; exports.normalizeCode = _chunk3NZA6WMUcjs.normalizeCode; exports.plural = plural; exports.pluralCount = pluralCount; exports.pluralPhrase = pluralPhrase; exports.pluralPhraseCount = pluralPhraseCount; exports.processImportBundle = _chunkY2SVZ6GEcjs.processImportBundle; exports.toBiomarkerTests = _chunk3NZA6WMUcjs.toBiomarkerTests; exports.unitToUCUM = _chunkMJ254F5Kcjs.unitToUCUM; exports.userProfileToFHIR = _chunkQ3O23BM7cjs.userProfileToFHIR; exports.validateCNS = validateCNS; exports.validateCPF = validateCPF; exports.validateFHIRDiagnosticReport = _chunk3ILBFLVQcjs.validateFHIRDiagnosticReport; exports.validateFHIRImportBundle = _chunk3ILBFLVQcjs.validateFHIRImportBundle; exports.validateFHIRObservation = _chunk3ILBFLVQcjs.validateFHIRObservation; exports.validateLoincNameMatch = _chunk3NZA6WMUcjs.validateLoincNameMatch;
 //# sourceMappingURL=index.cjs.map

package/dist/index.js

@@ -3,14 +3,14 @@ import {
   labReportToFHIR,
   labResultToFHIRBundle,
   userProfileToFHIR
-} from "./chunk-NR4OTNC4.js";
+} from "./chunk-5BDMX2JP.js";
 import {
   MAX_FILE_SIZE,
   MAX_OBSERVATIONS,
   extractObservationsFromBundle,
   mapFHIRObservationToInternal,
   processImportBundle
-} from "./chunk-4YQOKZX7.js";
+} from "./chunk-4I5G4SJ6.js";
 import {
   BIOMARKER_DEFINITIONS,
   CAC_INDICATOR_CODES,
@@ -43,7 +43,7 @@ import {
   normalizeCode,
   toBiomarkerTests,
   validateLoincNameMatch
-} from "./chunk-ICSMWCVT.js";
+} from "./chunk-FEVGNEFO.js";
 import {
   applyFallbackReferenceRanges,
   biomarkerRangeDefinitions,
@@ -51,7 +51,7 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-KIYE6S66.js";
+} from "./chunk-V5X3RU6M.js";
 import {
   BIOMARKER_DEFAULT_UNIT,
   BIOMARKER_UNITS,

package/dist/reference-ranges.cjs

@@ -5,7 +5,7 @@
 
 
 
-var _chunk3IOAP7CGcjs = require('./chunk-3IOAP7CG.cjs');
+var _chunkZKN5UI7Rcjs = require('./chunk-ZKN5UI7R.cjs');
 require('./chunk-MJ254F5K.cjs');
 
 
@@ -14,5 +14,5 @@ require('./chunk-MJ254F5K.cjs');
 
 
 
-exports.applyFallbackReferenceRanges = _chunk3IOAP7CGcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunk3IOAP7CGcjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunk3IOAP7CGcjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunk3IOAP7CGcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunk3IOAP7CGcjs.getRangeDirection; exports.getReferenceRange = _chunk3IOAP7CGcjs.getReferenceRange;
+exports.applyFallbackReferenceRanges = _chunkZKN5UI7Rcjs.applyFallbackReferenceRanges; exports.biomarkerRangeDefinitions = _chunkZKN5UI7Rcjs.biomarkerRangeDefinitions; exports.defaultReferenceRanges = _chunkZKN5UI7Rcjs.defaultReferenceRanges; exports.getFallbackReferenceRange = _chunkZKN5UI7Rcjs.getFallbackReferenceRange; exports.getRangeDirection = _chunkZKN5UI7Rcjs.getRangeDirection; exports.getReferenceRange = _chunkZKN5UI7Rcjs.getReferenceRange;
 //# sourceMappingURL=reference-ranges.cjs.map

package/dist/reference-ranges.js

@@ -5,7 +5,7 @@ import {
   getFallbackReferenceRange,
   getRangeDirection,
   getReferenceRange
-} from "./chunk-KIYE6S66.js";
+} from "./chunk-V5X3RU6M.js";
 import "./chunk-R4MUCMO3.js";
 export {
   applyFallbackReferenceRanges,

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@precisa-saude/fhir",
-  "version": "0.15.0",
+  "version": "0.15.2",
   "description": "Tipos FHIR R4, definições de biomarcadores, faixas de referência e conversores para o ecossistema de saúde brasileiro",
   "keywords": [
     "fhir",