@precisa-saude/fhir 0.1.8 → 0.2.0

package/dist/{chunk-FDOBUUGY.js → chunk-35S3GSRK.js}

@@ -8,26 +8,32 @@ var biomarkerRangeDefinitions = {
   // LIPIDS
   // =============================================================================
   Albumin_Creatinine_Ratio: {
-    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/g" }
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/g" },
+    source: "tietz-7ed-2015"
   },
   Adiponectin: {
-    default: { max: 26, min: 4, optimalMax: 20, optimalMin: 8, unit: "mcg/mL" }
+    default: { max: 26, min: 4, optimalMax: 20, optimalMin: 8, unit: "mcg/mL" },
+    source: "tietz-7ed-2015"
   },
   ADMA: {
-    default: { max: 0.7, min: 0.3, optimalMax: 0.55, optimalMin: 0.3, unit: "umol/L" }
+    default: { max: 0.7, min: 0.3, optimalMax: 0.55, optimalMin: 0.3, unit: "umol/L" },
+    source: "nemeth-adma-2017"
   },
   AFP: {
-    default: { max: 10, min: 0, optimalMax: 8, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 10, min: 0, optimalMax: 8, optimalMin: 0, unit: "ng/mL" },
+    source: "sturgeon-nacb-2008"
   },
   Albumin_Globulin_Ratio: {
-    default: { max: 2.5, min: 1, optimalMax: 2.2, optimalMin: 1.2, unit: "" }
+    default: { max: 2.5, min: 1, optimalMax: 2.2, optimalMin: 1.2, unit: "" },
+    source: "tietz-7ed-2015"
   },
   Albumin: {
     default: { max: 5, min: 3.5, optimalMax: 4.8, optimalMin: 4, unit: "g/dL" },
-    source: "sbpc-ml-2021"
+    source: "pns-bioquimica-2019"
   },
   AlkalinePhosphatase: {
     default: { max: 147, min: 44, optimalMax: 120, optimalMin: 50, unit: "U/L" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -43,7 +49,7 @@ var biomarkerRangeDefinitions = {
   },
   ALT: {
     default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/L" },
-    source: "sbpc-ml-2021",
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -59,6 +65,7 @@ var biomarkerRangeDefinitions = {
   },
   AMH: {
     default: { max: 10, min: 1, optimalMax: 6.9, optimalMin: 2, unit: "ng/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMax: 24,
@@ -92,29 +99,39 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Ammonia: {
-    default: { max: 45, min: 15, optimalMax: 40, optimalMin: 20, unit: "umol/L" }
+    default: { max: 45, min: 15, optimalMax: 40, optimalMin: 20, unit: "umol/L" },
+    source: "tietz-7ed-2015"
   },
   AntiThyroglobulin: {
-    default: { max: 115, min: 0, optimalMax: 40, optimalMin: 0, unit: "IU/mL" }
+    default: { max: 115, min: 0, optimalMax: 40, optimalMin: 0, unit: "IU/mL" },
+    source: "tietz-7ed-2015"
   },
   AntiTPO: {
-    default: { max: 34, min: 0, optimalMax: 9, optimalMin: 0, unit: "IU/mL" }
+    default: { max: 34, min: 0, optimalMax: 9, optimalMin: 0, unit: "IU/mL" },
+    source: "tietz-7ed-2015"
   },
   // Aortic valve calcium — no standardized clinical threshold; use mild cutoff
+  // Cálcio de válvula aórtica — usa mesma classificação Agatston
   AorticValveCalcium: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   ApoA1: {
-    default: { max: 200, min: 100, optimalMax: 180, optimalMin: 120, unit: "mg/dL" }
+    default: { max: 200, min: 100, optimalMax: 180, optimalMin: 120, unit: "mg/dL" },
+    source: "contois-apoa1-1996"
   },
   ApoB: {
     default: { max: 90, min: 0, optimalMax: 70, optimalMin: 0, unit: "mg/dL" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "sbc-lipids-2025"
   },
   ApoCIII: {
-    default: { max: 10, min: 0, optimalMax: 7, optimalMin: 0, unit: "mg/dL" }
+    default: { max: 10, min: 0, optimalMax: 7, optimalMin: 0, unit: "mg/dL" },
+    source: "khetarpal-apociii-2016"
   },
+  // ApoCIII/ApoA1 Ratio: derivado de ApoCIII (~10 mg/dL) e ApoA1 (~100-150 mg/dL)
+  // NOTA: corte de 0.15 sem fonte publicada — valor calculado, não validado clinicamente
   ApoCIII_ApoA1_Ratio: {
     default: { max: 0.15, min: 0, optimalMax: 0.1, optimalMin: 0, unit: "" }
   },
@@ -122,18 +139,21 @@ var biomarkerRangeDefinitions = {
   // THYROID
   // =============================================================================
   Omega6_AA: {
-    default: { max: 15, min: 5, optimalMax: 12, optimalMin: 7, unit: "%" }
+    default: { max: 15, min: 5, optimalMax: 12, optimalMin: 7, unit: "%" },
+    source: "simopoulos-omega-ratio-2002"
   },
   AA_EPA_Ratio: {
     default: { max: 15, min: 1, optimalMax: 5, optimalMin: 1.5, unit: "" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "simopoulos-omega-ratio-2002"
   },
   Arsenic: {
-    default: { max: 35, min: 0, optimalMax: 20, optimalMin: 0, unit: "mcg/L" }
+    default: { max: 35, min: 0, optimalMax: 20, optimalMin: 0, unit: "mcg/L" },
+    source: "nr7-pcmso-2020"
   },
   AST: {
     default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/L" },
-    source: "sbpc-ml-2021",
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -148,125 +168,156 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Basophils: {
-    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   Basophils_Abs: {
-    default: { max: 0.1, min: 0, optimalMax: 0.05, optimalMin: 0, unit: "K/uL" }
+    default: { max: 0.1, min: 0, optimalMax: 0.05, optimalMin: 0, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   // =============================================================================
   // HEMATOLOGY - CBC
   // =============================================================================
   Bicarbonate: {
-    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" }
+    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" },
+    source: "tietz-7ed-2015"
   },
   BilirubinDirect: {
-    default: { max: 0.3, min: 0, optimalMax: 0.2, optimalMin: 0, unit: "mg/dL" }
+    default: { max: 0.3, min: 0, optimalMax: 0.2, optimalMin: 0, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   BilirubinIndirect: {
-    default: { max: 0.8, min: 0, optimalMax: 0.6, optimalMin: 0, unit: "mg/dL" }
+    default: { max: 0.8, min: 0, optimalMax: 0.6, optimalMin: 0, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   BilirubinTotal: {
-    default: { max: 1.2, min: 0.1, optimalMax: 0.9, optimalMin: 0.2, unit: "mg/dL" }
+    default: { max: 1.2, min: 0.1, optimalMax: 0.9, optimalMin: 0.2, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
+  // BNP: 35 pg/mL = corte não-agudo para triagem de IC (SBC IC 2018)
   BNP: {
-    default: { max: 100, min: 0, optimalMax: 50, optimalMin: 0, unit: "pg/mL" }
+    default: { max: 35, min: 0, optimalMax: 20, optimalMin: 0, unit: "pg/mL" },
+    source: "sbc-ic-2018"
   },
   BUN_Creatinine_Ratio: {
-    default: { max: 20, min: 10, optimalMax: 18, optimalMin: 12, unit: "" }
+    default: { max: 20, min: 10, optimalMax: 18, optimalMin: 12, unit: "" },
+    source: "tietz-7ed-2015"
   },
   CA125: {
-    default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/mL" }
+    default: { max: 35, min: 0, optimalMax: 25, optimalMin: 0, unit: "U/mL" },
+    source: "sturgeon-nacb-2008"
   },
   CA199: {
-    default: { max: 37, min: 0, optimalMax: 30, optimalMin: 0, unit: "U/mL" }
+    default: { max: 37, min: 0, optimalMax: 30, optimalMin: 0, unit: "U/mL" },
+    source: "sturgeon-nacb-2008"
   },
   // CAC: Agatston classification — 0=none, 1-99=mild, 100-399=moderate, 400+=severe
   // max=99 so only moderate+ scores (≥100) flag as ANORMAL; optimalMax=0 (zero is ideal)
   CAC: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
-  // Per-vessel scores (hidden) — no standardized thresholds, use same mild cutoff
+  // Per-vessel scores — same Agatston classification applied per vessel
   CAC_LAD: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   CAC_LCX: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   CAC_LMA: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   CAC_Percentile: {
     default: { max: 50, min: 0, optimalMax: 25, optimalMin: 0, unit: "%", warningMax: 75 },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   CAC_RCA: {
     default: { max: 99, min: 0, optimalMax: 0, optimalMin: 0, unit: "AU" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "rumberger-cac-1999"
   },
   Cadmium: {
-    default: { max: 1.2, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "mcg/L" }
+    default: { max: 1.2, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "mcg/L" },
+    source: "nr7-pcmso-2020"
   },
   Calcium: {
-    default: { max: 10.5, min: 8.5, optimalMax: 10, optimalMin: 9, unit: "mg/dL" }
+    default: { max: 10.5, min: 8.5, optimalMax: 10, optimalMin: 9, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   CEA: {
-    default: { max: 3, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 3, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" },
+    source: "sturgeon-nacb-2008"
   },
+  // CK: valores conservadores baseados em faixas laboratoriais típicas
   CK: {
     default: { max: 190, min: 30, optimalMax: 170, optimalMin: 40, unit: "U/L" },
+    source: "tietz-7ed-2015",
     variants: [
       { sex: "F", range: { max: 170, min: 30, optimalMax: 150, optimalMin: 40, unit: "U/L" } }
     ]
   },
   Chloride: {
-    default: { max: 106, min: 98, optimalMax: 105, optimalMin: 100, unit: "mEq/L" }
+    default: { max: 106, min: 98, optimalMax: 105, optimalMin: 100, unit: "mEq/L" },
+    source: "tietz-7ed-2015"
   },
   Cholesterol: {
     default: { max: 200, min: 0, optimalMax: 180, optimalMin: 0, unit: "mg/dL" },
-    source: "sbc-lipids-2017"
+    source: "sbc-lipids-2025"
   },
+  // Índice de Castelli I (CT/HDL-c)
   Cholesterol_HDL_Ratio: {
-    // Lower is better - Function Health reference: <= 3.5
-    default: { max: 5, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
+    // Índice de Castelli I — SBC 2017: M <4.9, F <4.3
+    default: { max: 4.9, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
     direction: "lower-better",
+    source: "castelli-ratio-1992",
     variants: [
       {
         ageMin: 18,
-        range: { max: 5, min: 0, optimalMax: 4, optimalMin: 0, unit: "" },
+        range: { max: 4.9, min: 0, optimalMax: 4, optimalMin: 0, unit: "" },
         sex: "M"
       },
       {
         ageMin: 18,
-        range: { max: 4.5, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
+        range: { max: 4.3, min: 0, optimalMax: 3.5, optimalMin: 0, unit: "" },
         sex: "F"
       }
     ]
   },
   CO2: {
-    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" }
+    default: { max: 29, min: 23, optimalMax: 28, optimalMin: 24, unit: "mEq/L" },
+    source: "tietz-7ed-2015"
   },
   Copper: {
-    default: { max: 175, min: 70, optimalMax: 150, optimalMin: 85, unit: "mcg/dL" }
+    default: { max: 175, min: 70, optimalMax: 150, optimalMin: 85, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   CoQ10: {
-    default: { max: 1.5, min: 0.5, optimalMax: 1.3, optimalMin: 0.7, unit: "mg/L" }
+    default: { max: 1.5, min: 0.5, optimalMax: 1.3, optimalMin: 0.7, unit: "mg/L" },
+    source: "tietz-7ed-2015"
   },
   Cortisol: {
-    default: { max: 25, min: 5, optimalMax: 20, optimalMin: 10, unit: "mcg/dL" }
+    default: { max: 25, min: 5, optimalMax: 20, optimalMin: 10, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   CortisolFree: {
-    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "mcg/dL" }
+    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   CPeptide: {
-    default: { max: 3.9, min: 0.8, optimalMax: 3, optimalMin: 1, unit: "ng/mL" }
+    default: { max: 3.9, min: 0.8, optimalMax: 3, optimalMin: 1, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   Creatinine: {
     default: { max: 1.2, min: 0.6, optimalMax: 1, optimalMin: 0.7, unit: "mg/dL" },
-    source: "sbpc-ml-2021",
+    source: "pns-bioquimica-2019",
     variants: [
       {
         ageMin: 18,
@@ -282,22 +333,28 @@ var biomarkerRangeDefinitions = {
   },
   CRP: {
     default: { max: 3, min: 0, optimalMax: 1, optimalMin: 0, unit: "mg/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "tietz-7ed-2015"
   },
   CystatinC: {
-    default: { max: 1, min: 0.5, optimalMax: 0.9, optimalMin: 0.6, unit: "mg/L" }
+    default: { max: 1, min: 0.5, optimalMax: 0.9, optimalMin: 0.6, unit: "mg/L" },
+    source: "tietz-7ed-2015"
   },
+  // D-Dímero: 500 ng/mL é o corte clínico padrão para exclusão de TEV
   DDimer: {
-    default: { max: 500, min: 0, optimalMax: 250, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 500, min: 0, optimalMax: 250, optimalMin: 0, unit: "ng/mL" },
+    source: "wells-ddimer-2003"
   },
   // =============================================================================
   // METABOLIC PANEL
   // =============================================================================
   Omega3_DHA: {
-    default: { max: 8, min: 2, optimalMax: 6.5, optimalMin: 3.5, unit: "%" }
+    default: { max: 8, min: 2, optimalMax: 6.5, optimalMin: 3.5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   DHEAS: {
     default: { max: 500, min: 100, optimalMax: 400, optimalMin: 150, unit: "mcg/dL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMax: 39,
@@ -336,10 +393,12 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Omega3_DPA: {
-    default: { max: 2, min: 0.3, optimalMax: 1.5, optimalMin: 0.5, unit: "%" }
+    default: { max: 2, min: 0.3, optimalMax: 1.5, optimalMin: 0.5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   eGFR: {
     default: { max: 120, min: 90, optimalMax: 120, optimalMin: 90, unit: "mL/min/1.73m\xB2" },
+    source: "kdigo-ckd-2024",
     variants: [
       {
         ageMin: 60,
@@ -350,22 +409,28 @@ var biomarkerRangeDefinitions = {
   },
   Eosinophils: {
     default: { max: 5, min: 0, optimalMax: 4, optimalMin: 1, unit: "%" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "pns-hemograma-2019"
   },
   Eosinophils_Abs: {
-    default: { max: 0.5, min: 0, optimalMax: 0.3, optimalMin: 0, unit: "K/uL" }
+    default: { max: 0.5, min: 0, optimalMax: 0.3, optimalMin: 0, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   Omega3_EPA: {
-    default: { max: 3.5, min: 0.5, optimalMax: 2.5, optimalMin: 1, unit: "%" }
+    default: { max: 3.5, min: 0.5, optimalMax: 2.5, optimalMin: 1, unit: "%" },
+    source: "harris-omega3-2004"
   },
   EPADPADHA: {
-    default: { max: 10, min: 3, optimalMax: 9, optimalMin: 5, unit: "%" }
+    default: { max: 10, min: 3, optimalMax: 9, optimalMin: 5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   ESR: {
-    default: { max: 20, min: 0, optimalMax: 10, optimalMin: 0, unit: "mm/hr" }
+    default: { max: 20, min: 0, optimalMax: 10, optimalMin: 0, unit: "mm/hr" },
+    source: "tietz-7ed-2015"
   },
   Estradiol: {
     default: { max: 40, min: 10, optimalMax: 35, optimalMin: 15, unit: "pg/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -386,41 +451,46 @@ var biomarkerRangeDefinitions = {
     ]
   },
   F2Isoprostanes: {
-    default: { max: 86, min: 0, optimalMax: 60, optimalMin: 0, unit: "pg/mL" }
+    default: { max: 86, min: 0, optimalMax: 60, optimalMin: 0, unit: "pg/mL" },
+    source: "tietz-7ed-2015"
   },
   Ferritin: {
-    default: { max: 300, min: 20, optimalMax: 150, optimalMin: 50, unit: "ng/mL" },
-    source: "sbpc-ml-2021",
+    default: { max: 150, min: 12, optimalMax: 120, optimalMin: 30, unit: "ng/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
-        range: { max: 400, min: 30, optimalMax: 200, optimalMin: 50, unit: "ng/mL" },
+        range: { max: 250, min: 20, optimalMax: 200, optimalMin: 40, unit: "ng/mL" },
         sex: "M"
       },
       {
         ageMax: 50,
         ageMin: 18,
-        range: { max: 150, min: 15, optimalMax: 100, optimalMin: 30, unit: "ng/mL" },
+        range: { max: 120, min: 10, optimalMax: 80, optimalMin: 20, unit: "ng/mL" },
         sex: "F"
       },
       {
         ageMin: 51,
-        range: { max: 300, min: 30, optimalMax: 150, optimalMin: 50, unit: "ng/mL" },
+        range: { max: 200, min: 20, optimalMax: 150, optimalMin: 30, unit: "ng/mL" },
         sex: "F"
       }
     ]
   },
+  // Fibrinogênio: 200-400 mg/dL — faixa de referência padrão (método de Clauss)
   Fibrinogen: {
-    default: { max: 400, min: 200, optimalMax: 350, optimalMin: 250, unit: "mg/dL" }
+    default: { max: 400, min: 200, optimalMax: 350, optimalMin: 250, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   FolicAcid: {
-    default: { max: 20, min: 3, optimalMax: 15, optimalMin: 5, unit: "ng/mL" }
+    default: { max: 20, min: 3, optimalMax: 15, optimalMin: 5, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // LIVER FUNCTION
   // =============================================================================
   FSH: {
     default: { max: 12.4, min: 1.5, optimalMax: 10, optimalMin: 3, unit: "mIU/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -443,7 +513,7 @@ var biomarkerRangeDefinitions = {
   GGT: {
     default: { max: 55, min: 0, optimalMax: 30, optimalMin: 0, unit: "U/L" },
     direction: "lower-better",
-    source: "sbpc-ml-2021",
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -458,20 +528,24 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Ghrelin: {
-    default: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 400, unit: "pg/mL" }
+    default: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 400, unit: "pg/mL" },
+    source: "tietz-7ed-2015"
   },
   Globulin: {
-    default: { max: 3.5, min: 2, optimalMax: 3.2, optimalMin: 2.3, unit: "g/dL" }
+    default: { max: 3.5, min: 2, optimalMax: 3.2, optimalMin: 2.3, unit: "g/dL" },
+    source: "tietz-7ed-2015"
   },
   Glucose: {
     default: { max: 100, min: 70, optimalMax: 90, optimalMin: 70, unit: "mg/dL" },
     source: "sbd-diabetes-2024"
   },
   GlycoMark: {
-    default: { max: 40, min: 10, optimalMax: 35, optimalMin: 15, unit: "mcg/mL" }
+    default: { max: 40, min: 10, optimalMax: 35, optimalMin: 15, unit: "mcg/mL" },
+    source: "tietz-7ed-2015"
   },
   GrowthHormone: {
-    default: { max: 5, min: 0, optimalMax: 3, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 5, min: 0, optimalMax: 3, optimalMin: 0, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   HbA1c: {
     default: { max: 5.7, min: 4, optimalMax: 5.3, optimalMin: 4.5, unit: "%" },
@@ -479,6 +553,7 @@ var biomarkerRangeDefinitions = {
   },
   Hct: {
     default: { max: 50, min: 36, optimalMax: 48, optimalMin: 40, unit: "%" },
+    source: "pns-hemograma-2019",
     variants: [
       {
         ageMin: 18,
@@ -495,7 +570,7 @@ var biomarkerRangeDefinitions = {
   HDL: {
     default: { max: 60, min: 40, optimalMax: 60, optimalMin: 50, unit: "mg/dL" },
     direction: "higher-better",
-    source: "sbc-lipids-2017",
+    source: "sbc-lipids-2025",
     variants: [
       {
         ageMin: 18,
@@ -513,13 +588,15 @@ var biomarkerRangeDefinitions = {
     // HDL Large: higher is better
     // Quest Ion Mobility reference: Male 4334-10815, Female 5038-17886 nmol/L, optimal >6729
     default: { max: 17886, min: 4334, optimalMax: 17886, optimalMin: 6729, unit: "nmol/L" },
-    direction: "higher-better"
+    direction: "higher-better",
+    source: "caulfield-ionmobility-2008"
   },
   // =============================================================================
   // INFLAMMATION
   // =============================================================================
   Hgb: {
     default: { max: 17.5, min: 12, optimalMax: 16, optimalMin: 13.5, unit: "g/dL" },
+    source: "pns-hemograma-2019",
     variants: [
       {
         ageMin: 18,
@@ -535,23 +612,28 @@ var biomarkerRangeDefinitions = {
   },
   HOMA_IR: {
     default: { max: 2.5, min: 0, optimalMax: 1.5, optimalMin: 0, unit: "" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "tietz-7ed-2015"
   },
   Homocysteine: {
     default: { max: 15, min: 4, optimalMax: 10, optimalMin: 5, unit: "umol/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "selhub-homocysteine-1999"
   },
   IGF1: {
-    default: { max: 350, min: 100, optimalMax: 300, optimalMin: 150, unit: "ng/mL" }
+    default: { max: 350, min: 100, optimalMax: 300, optimalMin: 150, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // METABOLIC
   // =============================================================================
   ImmatureGranulocytes: {
-    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" },
+    source: "tietz-7ed-2015"
   },
   Insulin: {
-    default: { max: 25, min: 2, optimalMax: 8, optimalMin: 3, unit: "\xB5IU/mL" }
+    default: { max: 25, min: 2, optimalMax: 8, optimalMin: 3, unit: "\xB5IU/mL" },
+    source: "tietz-7ed-2015"
   },
   Iron: {
     default: { max: 170, min: 60, optimalMax: 140, optimalMin: 80, unit: "mcg/dL" },
@@ -570,30 +652,34 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Lactate: {
-    default: { max: 2.2, min: 0.5, optimalMax: 1.8, optimalMin: 0.7, unit: "mmol/L" }
+    default: { max: 2.2, min: 0.5, optimalMax: 1.8, optimalMin: 0.7, unit: "mmol/L" },
+    source: "tietz-7ed-2015"
   },
   LDL: {
     default: { max: 100, min: 0, optimalMax: 70, optimalMin: 0, unit: "mg/dL" },
     direction: "lower-better",
-    source: "sbc-lipids-2017"
+    source: "sbc-lipids-2025"
   },
   LDL_Medium: {
     // LDL Medium (LDL Média): lower is better
     // Quest Ion Mobility reference: Male 167-485, Female 121-397 nmol/L, optimal <215
     default: { max: 485, min: 121, optimalMax: 215, optimalMin: 121, unit: "nmol/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "caulfield-ionmobility-2008"
   },
   LDL_ParticleNumber: {
     // LDL Particle Number: lower is better
     // Quest Ion Mobility reference: 1016-2185 nmol/L, optimal <1138
     default: { max: 2185, min: 1016, optimalMax: 1138, optimalMin: 1016, unit: "nmol/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "caulfield-ionmobility-2008"
   },
   LDL_Peak_Size: {
     // LDL Peak Size: higher is better (larger particles less atherogenic)
     // Quest Ion Mobility reference: optimal >222.9 Å (22.29 nm)
     default: { max: 250, min: 217.4, optimalMax: 250, optimalMin: 222.9, unit: "\xC5" },
-    direction: "higher-better"
+    direction: "higher-better",
+    source: "caulfield-ionmobility-2008"
   },
   // =============================================================================
   // IRON STUDIES
@@ -602,14 +688,17 @@ var biomarkerRangeDefinitions = {
     // LDL Small (LDL Pequena): lower is better (small dense LDL is most atherogenic)
     // Quest Ion Mobility reference: Male 123-441, Female 126-382 nmol/L, optimal <142
     default: { max: 441, min: 123, optimalMax: 142, optimalMin: 123, unit: "nmol/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "caulfield-ionmobility-2008"
   },
   Lead: {
-    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "mcg/dL" }
+    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "mcg/dL" },
+    source: "nr7-pcmso-2020"
   },
   Leptin: {
     default: { max: 15, min: 2, optimalMax: 12, optimalMin: 3, unit: "ng/mL" },
     direction: "lower-better",
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -625,6 +714,7 @@ var biomarkerRangeDefinitions = {
   },
   LH: {
     default: { max: 8.6, min: 1.7, optimalMax: 8, optimalMin: 2, unit: "mIU/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -645,123 +735,158 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Omega6_LA: {
-    default: { max: 35, min: 15, optimalMax: 28, optimalMin: 18, unit: "%" }
+    default: { max: 35, min: 15, optimalMax: 28, optimalMin: 18, unit: "%" },
+    source: "simopoulos-omega-ratio-2002"
   },
   // =============================================================================
   // VITAMINS
   // =============================================================================
   Lipoprotein_a: {
     default: { max: 75, min: 0, optimalMax: 30, optimalMin: 0, unit: "nmol/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "sbc-lipids-2025"
   },
   Lymphocytes: {
-    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" }
+    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   Lymphocytes_Abs: {
-    default: { max: 4, min: 1, optimalMax: 3, optimalMin: 1.5, unit: "K/uL" }
+    default: { max: 4, min: 1, optimalMax: 3, optimalMin: 1.5, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   Magnesium: {
-    default: { max: 2.2, min: 1.7, optimalMax: 2.1, optimalMin: 1.9, unit: "mg/dL" }
+    default: { max: 2.2, min: 1.7, optimalMax: 2.1, optimalMin: 1.9, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   Magnesium_RBC: {
-    default: { max: 6.8, min: 4, optimalMax: 6, optimalMin: 4.5, unit: "mg/dL" }
+    default: { max: 6.8, min: 4, optimalMax: 6, optimalMin: 4.5, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   MCH: {
-    default: { max: 33, min: 27, optimalMax: 32, optimalMin: 28, unit: "pg" }
+    default: { max: 33, min: 27, optimalMax: 32, optimalMin: 28, unit: "pg" },
+    source: "pns-hemograma-2019"
   },
   MCHC: {
-    default: { max: 36, min: 32, optimalMax: 35, optimalMin: 33, unit: "g/dL" }
+    default: { max: 36, min: 32, optimalMax: 35, optimalMin: 33, unit: "g/dL" },
+    source: "pns-hemograma-2019"
   },
   MCV: {
-    default: { max: 100, min: 80, optimalMax: 98, optimalMin: 82, unit: "fL" }
+    default: { max: 100, min: 80, optimalMax: 98, optimalMin: 82, unit: "fL" },
+    source: "pns-hemograma-2019"
   },
   Mercury: {
-    default: { max: 10, min: 0, optimalMax: 5, optimalMin: 0, unit: "mcg/L" }
+    default: { max: 10, min: 0, optimalMax: 5, optimalMin: 0, unit: "mcg/L" },
+    source: "nr7-pcmso-2020"
   },
   Microalbumin: {
-    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" }
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" },
+    source: "kdigo-ckd-2024"
   },
   // =============================================================================
   // HORMONES
   // =============================================================================
   MMA: {
-    default: { max: 378, min: 0, optimalMax: 270, optimalMin: 0, unit: "nmol/L" }
+    default: { max: 378, min: 0, optimalMax: 270, optimalMin: 0, unit: "nmol/L" },
+    source: "tietz-7ed-2015"
   },
   Monocytes: {
-    default: { max: 8, min: 2, optimalMax: 7, optimalMin: 3, unit: "%" }
+    default: { max: 8, min: 2, optimalMax: 7, optimalMin: 3, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   Monocytes_Abs: {
-    default: { max: 0.8, min: 0.2, optimalMax: 0.7, optimalMin: 0.3, unit: "K/uL" }
+    default: { max: 0.8, min: 0.2, optimalMax: 0.7, optimalMin: 0.3, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   MPV: {
-    default: { max: 11.5, min: 7.5, optimalMax: 10.5, optimalMin: 8, unit: "fL" }
+    default: { max: 11.5, min: 7.5, optimalMax: 10.5, optimalMin: 8, unit: "fL" },
+    source: "pns-hemograma-2019"
   },
+  // MPO: Meuwese 2007 (EPIC-Norfolk) — risco CV elevado >322 pmol/L
   Myeloperoxidase: {
-    default: { max: 420, min: 0, optimalMax: 300, optimalMin: 0, unit: "pmol/L" }
+    default: { max: 470, min: 0, optimalMax: 322, optimalMin: 0, unit: "pmol/L" },
+    source: "meuwese-mpo-2007"
   },
   // WBC Differential (%)
   Neutrophils: {
-    default: { max: 70, min: 40, optimalMax: 65, optimalMin: 50, unit: "%" }
+    default: { max: 70, min: 40, optimalMax: 65, optimalMin: 50, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   // WBC Differential (Absolute)
   Neutrophils_Abs: {
-    default: { max: 8, min: 1.5, optimalMax: 6, optimalMin: 2, unit: "K/uL" }
+    default: { max: 8, min: 1.5, optimalMax: 6, optimalMin: 2, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   NonHDL_Cholesterol: {
     default: { max: 130, min: 0, optimalMax: 100, optimalMin: 0, unit: "mg/dL" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "sbc-lipids-2025"
   },
   NRBC: {
-    default: { max: 0, min: 0, optimalMax: 0, optimalMin: 0, unit: "/100WBC" }
+    default: { max: 0, min: 0, optimalMax: 0, optimalMin: 0, unit: "/100WBC" },
+    source: "tietz-7ed-2015"
   },
   NTproBNP: {
-    default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "pg/mL" }
+    default: { max: 125, min: 0, optimalMax: 75, optimalMin: 0, unit: "pg/mL" },
+    source: "sbc-ic-2018"
   },
   Oleic_Acid: {
-    default: { max: 25, min: 15, optimalMax: 22, optimalMin: 18, unit: "%" }
+    default: { max: 25, min: 15, optimalMax: 22, optimalMin: 18, unit: "%" },
+    source: "tietz-7ed-2015"
   },
   Omega3_Index: {
-    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" }
+    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   Omega3_Total: {
-    default: { max: 12, min: 3, optimalMax: 10, optimalMin: 5.5, unit: "%" }
+    default: { max: 12, min: 3, optimalMax: 10, optimalMin: 5.5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   Omega6_Total: {
-    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" }
+    default: { max: 40, min: 20, optimalMax: 35, optimalMin: 25, unit: "%" },
+    source: "simopoulos-omega-ratio-2002"
   },
   Omega6_Omega3_Ratio: {
     default: { max: 10, min: 1, optimalMax: 4, optimalMin: 1, unit: "" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "simopoulos-omega-ratio-2002"
   },
   // =============================================================================
   // TUMOR MARKERS
   // =============================================================================
   OmegaCheck: {
-    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" }
+    default: { max: 8, min: 4, optimalMax: 8, optimalMin: 5.5, unit: "%" },
+    source: "harris-omega3-2004"
   },
   Palmitic_Acid: {
-    default: { max: 30, min: 20, optimalMax: 27, optimalMin: 22, unit: "%" }
+    default: { max: 30, min: 20, optimalMax: 27, optimalMin: 22, unit: "%" },
+    source: "tietz-7ed-2015"
   },
   Phosphorus: {
-    default: { max: 4.5, min: 2.5, optimalMax: 4, optimalMin: 3, unit: "mg/dL" }
+    default: { max: 4.5, min: 2.5, optimalMax: 4, optimalMin: 3, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   Platelets: {
-    default: { max: 400, min: 150, optimalMax: 350, optimalMin: 180, unit: "K/uL" }
+    default: { max: 400, min: 150, optimalMax: 350, optimalMin: 180, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   Potassium: {
-    default: { max: 5, min: 3.5, optimalMax: 4.6, optimalMin: 3.8, unit: "mEq/L" }
+    default: { max: 5, min: 3.5, optimalMax: 4.6, optimalMin: 3.8, unit: "mEq/L" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // CARDIAC MARKERS
   // =============================================================================
   Prealbumin: {
-    default: { max: 38, min: 18, optimalMax: 35, optimalMin: 20, unit: "mg/dL" }
+    default: { max: 38, min: 18, optimalMax: 35, optimalMin: 20, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   Progesterone: {
-    default: { max: 0.9, min: 0.1, optimalMax: 0.7, optimalMin: 0.2, unit: "ng/mL" }
+    default: { max: 0.9, min: 0.1, optimalMax: 0.7, optimalMin: 0.2, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   Prolactin: {
     default: { max: 18, min: 2, optimalMax: 15, optimalMin: 4, unit: "ng/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -777,6 +902,7 @@ var biomarkerRangeDefinitions = {
   },
   PSA: {
     default: { max: 4, min: 0, optimalMax: 2.5, optimalMin: 0, unit: "ng/mL" },
+    source: "sturgeon-nacb-2008",
     variants: [
       {
         ageMax: 49,
@@ -805,6 +931,7 @@ var biomarkerRangeDefinitions = {
   },
   RBC: {
     default: { max: 5.5, min: 4, optimalMax: 5.2, optimalMin: 4.3, unit: "M/uL" },
+    source: "pns-hemograma-2019",
     variants: [
       {
         ageMin: 18,
@@ -822,19 +949,24 @@ var biomarkerRangeDefinitions = {
   // URINALYSIS
   // =============================================================================
   RDW: {
-    default: { max: 14.5, min: 11.5, optimalMax: 14, optimalMin: 12, unit: "%" }
+    default: { max: 14.5, min: 11.5, optimalMax: 14, optimalMin: 12, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   Reticulocytes: {
-    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "%" }
+    default: { max: 2.5, min: 0.5, optimalMax: 2, optimalMin: 0.8, unit: "%" },
+    source: "pns-hemograma-2019"
   },
   SDMA: {
-    default: { max: 0.6, min: 0.3, optimalMax: 0.5, optimalMin: 0.3, unit: "umol/L" }
+    default: { max: 0.6, min: 0.3, optimalMax: 0.5, optimalMin: 0.3, unit: "umol/L" },
+    source: "schwedhelm-sdma-2011"
   },
   Selenium: {
-    default: { max: 150, min: 70, optimalMax: 125, optimalMin: 85, unit: "mcg/L" }
+    default: { max: 150, min: 70, optimalMax: 125, optimalMin: 85, unit: "mcg/L" },
+    source: "tietz-7ed-2015"
   },
   SHBG: {
     default: { max: 54, min: 18, optimalMax: 50, optimalMin: 20, unit: "nmol/L" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -849,34 +981,42 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Sodium: {
-    default: { max: 145, min: 136, optimalMax: 143, optimalMin: 138, unit: "mEq/L" }
+    default: { max: 145, min: 136, optimalMax: 143, optimalMin: 138, unit: "mEq/L" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // KIDNEY FUNCTION
   // =============================================================================
   SpecificGravity_Urine: {
-    default: { max: 1.03, min: 1.005, optimalMax: 1.025, optimalMin: 1.01, unit: "SG" }
+    default: { max: 1.03, min: 1.005, optimalMax: 1.025, optimalMin: 1.01, unit: "SG" },
+    source: "tietz-7ed-2015"
   },
   Stearic_Acid: {
-    default: { max: 14, min: 8, optimalMax: 12, optimalMin: 10, unit: "%" }
+    default: { max: 14, min: 8, optimalMax: 12, optimalMin: 10, unit: "%" },
+    source: "tietz-7ed-2015"
   },
   T3Free: {
-    default: { max: 4.2, min: 2.3, optimalMax: 3.8, optimalMin: 2.8, unit: "pg/mL" }
+    default: { max: 4.2, min: 2.3, optimalMax: 3.8, optimalMin: 2.8, unit: "pg/mL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // OMEGA FATTY ACIDS
   // =============================================================================
   T3Reverse: {
-    default: { max: 27, min: 9, optimalMax: 22, optimalMin: 12, unit: "ng/dL" }
+    default: { max: 24, min: 10, optimalMax: 20, optimalMin: 12, unit: "ng/dL" },
+    source: "tietz-7ed-2015"
   },
   T4Free: {
-    default: { max: 1.8, min: 0.8, optimalMax: 1.5, optimalMin: 1, unit: "ng/dL" }
+    default: { max: 1.8, min: 0.8, optimalMax: 1.5, optimalMin: 1, unit: "ng/dL" },
+    source: "tietz-7ed-2015"
   },
   T4Total: {
-    default: { max: 12, min: 4.5, optimalMax: 10, optimalMin: 6, unit: "ug/dL" }
+    default: { max: 12, min: 4.5, optimalMax: 10, optimalMin: 6, unit: "ug/dL" },
+    source: "tietz-7ed-2015"
   },
   Testosterone: {
     default: { max: 1e3, min: 300, optimalMax: 800, optimalMin: 500, unit: "ng/dL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMax: 49,
@@ -897,12 +1037,14 @@ var biomarkerRangeDefinitions = {
     ]
   },
   TestosteroneBioavailable: {
-    default: { max: 200, min: 50, optimalMax: 150, optimalMin: 80, unit: "ng/dL" }
+    default: { max: 200, min: 50, optimalMax: 150, optimalMin: 80, unit: "ng/dL" },
+    source: "tietz-7ed-2015"
   },
   // TestosteroneFree - using direct immunoassay ranges (Quest/LabCorp standard)
   // Previous values (9.3-26.5 pg/mL) were based on equilibrium dialysis method
   TestosteroneFree: {
     default: { max: 155, min: 35, optimalMax: 120, optimalMin: 50, unit: "pg/mL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMax: 49,
@@ -923,19 +1065,24 @@ var biomarkerRangeDefinitions = {
     ]
   },
   TIBC: {
-    default: { max: 400, min: 250, optimalMax: 370, optimalMin: 280, unit: "mcg/dL" }
+    default: { max: 370, min: 250, optimalMax: 350, optimalMin: 280, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   TotalProtein: {
-    default: { max: 8.3, min: 6, optimalMax: 7.8, optimalMin: 6.5, unit: "g/dL" }
+    default: { max: 8.3, min: 6, optimalMax: 7.8, optimalMin: 6.5, unit: "g/dL" },
+    source: "tietz-7ed-2015"
   },
   Trans_Fat_Index: {
-    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" }
+    default: { max: 1, min: 0, optimalMax: 0.5, optimalMin: 0, unit: "%" },
+    source: "tietz-7ed-2015"
   },
   Transferrin: {
-    default: { max: 360, min: 200, optimalMax: 340, optimalMin: 220, unit: "mg/dL" }
+    default: { max: 360, min: 200, optimalMax: 340, optimalMin: 220, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   TransferrinSaturation: {
     default: { max: 50, min: 20, optimalMax: 45, optimalMin: 25, unit: "%" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -952,13 +1099,17 @@ var biomarkerRangeDefinitions = {
   Triglycerides: {
     default: { max: 150, min: 0, optimalMax: 100, optimalMin: 0, unit: "mg/dL" },
     direction: "lower-better",
-    source: "sbc-lipids-2017"
+    source: "sbc-lipids-2025"
   },
+  // TroponinI: 0.04 ng/mL = percentil 99 (ensaio Siemens TnI-Ultra)
   TroponinI: {
-    default: { max: 0.04, min: 0, optimalMax: 0.02, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 0.04, min: 0, optimalMax: 0.02, optimalMin: 0, unit: "ng/mL" },
+    source: "keller-tni-2013"
   },
+  // TroponinT: 14 ng/L = percentil 99 hs-cTnT (ensaio Roche Elecsys 5ª geração)
   TroponinT: {
-    default: { max: 14, min: 0, optimalMax: 10, optimalMin: 0, unit: "ng/L" }
+    default: { max: 14, min: 0, optimalMax: 10, optimalMin: 0, unit: "ng/L" },
+    source: "giannitsis-hstnt-2010"
   },
   TSH: {
     default: { max: 4, min: 0.4, optimalMax: 2.5, optimalMin: 1, unit: "\xB5IU/mL" },
@@ -972,10 +1123,12 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Urea: {
-    default: { max: 20, min: 7, optimalMax: 16, optimalMin: 10, unit: "mg/dL" }
+    default: { max: 20, min: 7, optimalMax: 16, optimalMin: 10, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   UricAcid: {
     default: { max: 7, min: 2.5, optimalMax: 5.5, optimalMin: 3, unit: "mg/dL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -990,72 +1143,89 @@ var biomarkerRangeDefinitions = {
     ]
   },
   Urobilinogen_Urine: {
-    default: { max: 1, min: 0.1, optimalMax: 1, optimalMin: 0.1, unit: "mg/dL" }
+    default: { max: 1, min: 0.1, optimalMax: 1, optimalMin: 0.1, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // ADVANCED CARDIOVASCULAR
   // =============================================================================
   pH_Urine: {
-    default: { max: 8, min: 4.5, optimalMax: 7, optimalMin: 5.5, unit: "pH" }
+    default: { max: 8, min: 4.5, optimalMax: 7, optimalMin: 5.5, unit: "pH" },
+    source: "tietz-7ed-2015"
   },
   HyalineCasts_Urine: {
-    default: { max: 2, min: 0, optimalMax: 1, optimalMin: 0, unit: "/LPF" }
+    default: { max: 2, min: 0, optimalMax: 1, optimalMin: 0, unit: "/LPF" },
+    source: "tietz-7ed-2015"
   },
   RBC_Urine: {
-    default: { max: 3, min: 0, optimalMax: 1, optimalMin: 0, unit: "/HPF" }
+    default: { max: 3, min: 0, optimalMax: 1, optimalMin: 0, unit: "/HPF" },
+    source: "tietz-7ed-2015"
   },
   SquamousEpithelial_Urine: {
-    default: { max: 15, min: 0, optimalMax: 5, optimalMin: 0, unit: "/HPF" }
+    default: { max: 15, min: 0, optimalMax: 5, optimalMin: 0, unit: "/HPF" },
+    source: "tietz-7ed-2015"
   },
   Leukocytes_Urine: {
-    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "/HPF" }
+    default: { max: 5, min: 0, optimalMax: 2, optimalMin: 0, unit: "/HPF" },
+    source: "tietz-7ed-2015"
   },
   Folate: {
-    default: { max: 20, min: 3.9, optimalMax: 17, optimalMin: 5, unit: "ng/mL" }
+    default: { max: 20, min: 3.9, optimalMax: 17, optimalMin: 5, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   VitaminA: {
-    default: { max: 100, min: 20, optimalMax: 80, optimalMin: 30, unit: "mcg/dL" }
+    default: { max: 100, min: 20, optimalMax: 80, optimalMin: 30, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // MINERALS
   // =============================================================================
   VitaminB1: {
-    default: { max: 180, min: 70, optimalMax: 150, optimalMin: 80, unit: "nmol/L" }
+    default: { max: 180, min: 70, optimalMax: 150, optimalMin: 80, unit: "nmol/L" },
+    source: "tietz-7ed-2015"
   },
   VitaminB12: {
     default: { max: 900, min: 200, optimalMax: 800, optimalMin: 400, unit: "pg/mL" },
-    source: "sbpc-ml-2021"
+    source: "tietz-7ed-2015"
   },
   VitaminB6: {
-    default: { max: 50, min: 5, optimalMax: 40, optimalMin: 10, unit: "ng/mL" }
+    default: { max: 50, min: 5, optimalMax: 40, optimalMin: 10, unit: "ng/mL" },
+    source: "tietz-7ed-2015"
   },
   VitaminC: {
-    default: { max: 2, min: 0.4, optimalMax: 1.5, optimalMin: 0.6, unit: "mg/dL" }
+    default: { max: 2, min: 0.4, optimalMax: 1.5, optimalMin: 0.6, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // HEAVY METALS
   // =============================================================================
   VitaminD: {
     default: { max: 100, min: 30, optimalMax: 70, optimalMin: 40, unit: "ng/mL" },
-    source: "sbem-thyroid-2013"
+    source: "sbem-vitamind-2014"
   },
   VitaminD_1_25: {
-    default: { max: 72, min: 18, optimalMax: 60, optimalMin: 25, unit: "pg/mL" }
+    default: { max: 72, min: 18, optimalMax: 60, optimalMin: 25, unit: "pg/mL" },
+    source: "tietz-7ed-2015"
   },
   VitaminE: {
-    default: { max: 17, min: 5.5, optimalMax: 14, optimalMin: 7, unit: "mg/L" }
+    default: { max: 17, min: 5.5, optimalMax: 14, optimalMin: 7, unit: "mg/L" },
+    source: "tietz-7ed-2015"
   },
+  // VLDL: estimado via fórmula de Friedewald (TG/5)
   VLDL: {
-    default: { max: 40, min: 5, optimalMax: 30, optimalMin: 10, unit: "mg/dL" }
+    default: { max: 30, min: 2, optimalMax: 20, optimalMin: 5, unit: "mg/dL" },
+    source: "friedewald-1972"
   },
   // =============================================================================
   // OTHER
   // =============================================================================
   WBC: {
-    default: { max: 11, min: 4, optimalMax: 8, optimalMin: 5, unit: "K/uL" }
+    default: { max: 11, min: 4, optimalMax: 8, optimalMin: 5, unit: "K/uL" },
+    source: "pns-hemograma-2019"
   },
   Zinc: {
-    default: { max: 120, min: 60, optimalMax: 100, optimalMin: 70, unit: "mcg/dL" }
+    default: { max: 120, min: 60, optimalMax: 100, optimalMin: 70, unit: "mcg/dL" },
+    source: "tietz-7ed-2015"
   },
   // =============================================================================
   // BODY COMPOSITION (DXA)
@@ -1063,6 +1233,7 @@ var biomarkerRangeDefinitions = {
   AndroidFatPct: {
     default: { max: 35, min: 10, optimalMax: 25, optimalMin: 15, unit: "%" },
     direction: "lower-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1079,6 +1250,7 @@ var biomarkerRangeDefinitions = {
   AndroidGynoidRatio: {
     default: { max: 1.2, min: 0.5, optimalMax: 1, optimalMin: 0.6, unit: "" },
     direction: "lower-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1095,6 +1267,7 @@ var biomarkerRangeDefinitions = {
   BMC: {
     default: { max: 3.5, min: 2, optimalMax: 3.2, optimalMin: 2.3, unit: "kg" },
     direction: "higher-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1113,6 +1286,7 @@ var biomarkerRangeDefinitions = {
   BodyFatPct: {
     default: { max: 30, min: 10, optimalMax: 25, optimalMin: 15, unit: "%" },
     direction: "lower-better",
+    source: "gallagher-bodyfat-2000",
     variants: [
       // Men — age brackets
       {
@@ -1179,6 +1353,7 @@ var biomarkerRangeDefinitions = {
   FatFreeMass: {
     default: { max: 80, min: 40, optimalMax: 70, optimalMin: 45, unit: "kg" },
     direction: "higher-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1195,6 +1370,7 @@ var biomarkerRangeDefinitions = {
   FatMass: {
     default: { max: 30, min: 5, optimalMax: 20, optimalMin: 8, unit: "kg" },
     direction: "lower-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1211,6 +1387,7 @@ var biomarkerRangeDefinitions = {
   GynoidFatPct: {
     default: { max: 45, min: 15, optimalMax: 35, optimalMin: 20, unit: "%" },
     direction: "lower-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1227,6 +1404,7 @@ var biomarkerRangeDefinitions = {
   LeanMass: {
     default: { max: 75, min: 35, optimalMax: 65, optimalMin: 40, unit: "kg" },
     direction: "higher-better",
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1242,6 +1420,7 @@ var biomarkerRangeDefinitions = {
   },
   TotalMass: {
     default: { max: 100, min: 50, optimalMax: 85, optimalMin: 55, unit: "kg" },
+    source: "kelly-dxa-2009",
     variants: [
       {
         ageMin: 18,
@@ -1258,6 +1437,7 @@ var biomarkerRangeDefinitions = {
   VATMass: {
     default: { max: 1.5, min: 0, optimalMax: 0.8, optimalMin: 0, unit: "kg" },
     direction: "lower-better",
+    source: "ofenheimer-vat-2020",
     variants: [
       {
         ageMin: 18,
@@ -1274,6 +1454,7 @@ var biomarkerRangeDefinitions = {
   VATVolume: {
     default: { max: 1500, min: 0, optimalMax: 800, optimalMin: 0, unit: "cm\xB3" },
     direction: "lower-better",
+    source: "ofenheimer-vat-2020",
     variants: [
       {
         ageMin: 18,
@@ -1292,24 +1473,29 @@ var biomarkerRangeDefinitions = {
   // =============================================================================
   BMD_Total: {
     default: { max: 1.4, min: 0.9, optimalMax: 1.3, optimalMin: 1, unit: "g/cm\xB2" },
-    direction: "higher-better"
+    direction: "higher-better",
+    source: "who-osteoporosis-1994"
   },
   TScore_Total: {
     default: { max: 4, min: -1, optimalMax: 2, optimalMin: -0.5, unit: "" },
-    direction: "higher-better"
+    direction: "higher-better",
+    source: "who-osteoporosis-1994"
   },
   ZScore_Total: {
     default: { max: 2, min: -2, optimalMax: 1, optimalMin: -1, unit: "" },
-    direction: "higher-better"
+    direction: "higher-better",
+    source: "who-osteoporosis-1994"
   },
   // =============================================================================
   // MISSING LAB RANGES
   // =============================================================================
   Amylase: {
-    default: { max: 100, min: 28, optimalMax: 90, optimalMin: 35, unit: "U/L" }
+    default: { max: 100, min: 28, optimalMax: 90, optimalMin: 35, unit: "U/L" },
+    source: "tietz-7ed-2015"
   },
   Creatinine_Urine: {
     default: { max: 300, min: 20, optimalMax: 250, optimalMin: 40, unit: "mg/dL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -1324,39 +1510,49 @@ var biomarkerRangeDefinitions = {
     ]
   },
   IgA: {
-    default: { max: 400, min: 70, optimalMax: 350, optimalMin: 100, unit: "mg/dL" }
+    default: { max: 400, min: 70, optimalMax: 350, optimalMin: 100, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   Lipase: {
-    default: { max: 60, min: 0, optimalMax: 50, optimalMin: 10, unit: "U/L" }
+    default: { max: 60, min: 0, optimalMax: 50, optimalMin: 10, unit: "U/L" },
+    source: "tietz-7ed-2015"
   },
   Microalbumin_Urine: {
-    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" }
+    default: { max: 30, min: 0, optimalMax: 20, optimalMin: 0, unit: "mg/L" },
+    source: "kdigo-ckd-2024"
   },
   PSA_Free: {
-    default: { max: 1.5, min: 0, optimalMax: 1, optimalMin: 0, unit: "ng/mL" }
+    default: { max: 1.5, min: 0, optimalMax: 1, optimalMin: 0, unit: "ng/mL" },
+    source: "sturgeon-nacb-2008"
   },
   PSA_FreeRatio: {
-    default: { max: 100, min: 25, optimalMax: 100, optimalMin: 30, unit: "%" }
+    default: { max: 100, min: 25, optimalMax: 100, optimalMin: 30, unit: "%" },
+    source: "sturgeon-nacb-2008"
   },
   // BMI - WHO classification: 18.5–24.9 normal, 25–29.9 overweight, ≥30 obese
   BMI: {
-    default: { max: 30, min: 18.5, optimalMax: 24.9, optimalMin: 18.5, unit: "kg/m2" }
+    default: { max: 30, min: 18.5, optimalMax: 24.9, optimalMin: 18.5, unit: "kg/m2" },
+    source: "who-obesity-2000"
   },
   // eAG - Estimated Average Glucose, derived from HbA1c (ADAG study)
   eAG: {
-    default: { max: 154, min: 70, optimalMax: 126, optimalMin: 70, unit: "mg/dL" }
+    default: { max: 154, min: 70, optimalMax: 126, optimalMin: 70, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   // INR - International Normalized Ratio (non-anticoagulated patients)
   INR: {
-    default: { max: 1.2, min: 0.8, optimalMax: 1.1, optimalMin: 0.9, unit: "ratio" }
+    default: { max: 1.2, min: 0.8, optimalMax: 1.1, optimalMin: 0.9, unit: "ratio" },
+    source: "tietz-7ed-2015"
   },
   // Prothrombin Time
   ProthrombinTime: {
-    default: { max: 13.5, min: 11, optimalMax: 13, optimalMin: 11, unit: "seconds" }
+    default: { max: 13.5, min: 11, optimalMax: 13, optimalMin: 11, unit: "seconds" },
+    source: "tietz-7ed-2015"
   },
   // DHT - Dihydrotestosterone (adult male reference; female values are much lower)
   DHT: {
     default: { max: 85, min: 30, optimalMax: 85, optimalMin: 30, unit: "ng/dL" },
+    source: "tietz-7ed-2015",
     variants: [
       {
         ageMin: 18,
@@ -1373,21 +1569,25 @@ var biomarkerRangeDefinitions = {
   // Total IgE - higher values suggest atopy/allergic sensitization
   IgE_Total: {
     default: { max: 100, min: 0, optimalMax: 100, optimalMin: 0, unit: "IU/mL" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "tietz-7ed-2015"
   },
   // IgG - Immunoglobulin G
   IgG: {
-    default: { max: 1600, min: 700, optimalMax: 1600, optimalMin: 700, unit: "mg/dL" }
+    default: { max: 1600, min: 700, optimalMax: 1600, optimalMin: 700, unit: "mg/dL" },
+    source: "tietz-7ed-2015"
   },
   // IgE E1 Cat Dander - Class 0 (≤0.35 kU/L) = negative
   IgE_E1_CatDander: {
     default: { max: 0.35, min: 0, optimalMax: 0.35, optimalMin: 0, unit: "kU/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "tietz-7ed-2015"
   },
   // IgE GX1 Grasses - Class 0 (≤0.35 kU/L) = negative
   IgE_GX1_Grasses: {
     default: { max: 0.35, min: 0, optimalMax: 0.35, optimalMin: 0, unit: "kU/L" },
-    direction: "lower-better"
+    direction: "lower-better",
+    source: "tietz-7ed-2015"
   }
 };
 var defaultReferenceRanges = Object.fromEntries(
@@ -1461,4 +1661,4 @@ export {
   getFallbackReferenceRange,
   applyFallbackReferenceRanges
 };
-//# sourceMappingURL=chunk-FDOBUUGY.js.map
+//# sourceMappingURL=chunk-35S3GSRK.js.map