@platforma-sdk/ui-vue 1.42.53 → 1.43.1

package/dist/components/PlMultiSequenceAlignment/data.js.map

@@ -1 +1 @@
-{"version":3,"file":"data.js","sources":["../../../src/components/PlMultiSequenceAlignment/data.ts"],"sourcesContent":["import { isJsonEqual } from '@milaboratories/helpers';\nimport type { ListOptionNormalized } from '@milaboratories/uikit';\nimport {\n  type CalculateTableDataRequest,\n  type CanonicalizedJson,\n  canonicalizeJson,\n  createRowSelectionColumn,\n  ensureError,\n  getAxisId,\n  getRawPlatformaInstance,\n  isLabelColumn,\n  isLinkerColumn,\n  type JoinEntry,\n  matchAxisId,\n  parseJson,\n  type PColumnIdAndSpec,\n  type PFrameHandle,\n  type PlMultiSequenceAlignmentColorSchemeOption,\n  type PlMultiSequenceAlignmentSettings,\n  type PlSelectionModel,\n  type PObjectId,\n  type PTableColumnId,\n  type PTableSorting,\n  pTableValue,\n  readAnnotation,\n  Annotation,\n  readAnnotationJson,\n} from '@platforma-sdk/model';\nimport { ref, watch } from 'vue';\nimport { highlightByChemicalProperties } from './chemical-properties';\nimport {\n  highlightByMarkup,\n  markupAlignedSequence,\n  parseMarkup,\n} from './markup';\nimport { multiSequenceAlignment } from './multi-sequence-alignment';\nimport { getResidueCounts } from './residue-counts';\nimport type { HighlightLegend, ResidueCounts } from './types';\n\nconst getPFrameDriver = () => getRawPlatformaInstance().pFrameDriver;\n\nexport const sequenceLimit = 1000;\n\nexport const useSequenceColumnsOptions = refreshOnDeepChange(\n  getSequenceColumnsOptions,\n);\n\nexport const useLabelColumnsOptions = refreshOnDeepChange(\n  getLabelColumnsOptions,\n);\n\nexport const useMarkupColumnsOptions = refreshOnDeepChange(\n  getMarkupColumnsOptions,\n);\n\nexport const useMultipleAlignmentData = refreshOnDeepChange(\n  getMultipleAlignmentData,\n);\n\nasync function getSequenceColumnsOptions({\n  pFrame,\n  sequenceColumnPredicate,\n}: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnPredicate: (column: PColumnIdAndSpec) => boolean;\n}): Promise<OptionsWithDefaults<PObjectId> | undefined> {\n  if (!pFrame) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n  const options = columns.values()\n    .filter((column) => sequenceColumnPredicate(column))\n    .map(({ spec, columnId }) => ({\n      label: readAnnotation(spec, Annotation.Label) ?? 'Unlabeled column',\n      value: columnId,\n    }))\n    .toArray();\n  const defaults = options.map(({ value }) => value);\n  return { options, defaults };\n}\n\nasync function getLabelColumnsOptions({\n  pFrame,\n  sequenceColumnIds,\n}: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnIds: PObjectId[] | undefined;\n}): Promise<OptionsWithDefaults<PTableColumnId> | undefined> {\n  if (!pFrame || !sequenceColumnIds) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n  const optionMap = new Map<CanonicalizedJson<PTableColumnId>, string>();\n\n  const sequenceColumnsAxes = new Map(\n    sequenceColumnIds.values().flatMap((id) => {\n      const column = columns.find(({ columnId }) => columnId === id);\n      if (!column) {\n        throw new Error(`Couldn't find sequence column (ID: \\`${id}\\`).`);\n      }\n      return column.spec.axesSpec.values()\n        .map((spec) => [canonicalizeJson(getAxisId(spec)), spec]);\n    }),\n  );\n\n  for (const [axisIdJson, axisSpec] of sequenceColumnsAxes.entries()) {\n    const axisId = parseJson(axisIdJson);\n    const labelColumn = columns.find(({ spec }) =>\n      isLabelColumn(spec) && matchAxisId(axisId, getAxisId(spec.axesSpec[0])),\n    );\n    optionMap.set(\n      labelColumn\n        ? canonicalizeJson({ type: 'column', id: labelColumn.columnId })\n        : canonicalizeJson({ type: 'axis', id: axisId }),\n      readAnnotation(labelColumn?.spec, Annotation.Label)\n      ?? readAnnotation(axisSpec, Annotation.Label)\n      ?? 'Unlabeled axis',\n    );\n  }\n\n  const { hits: compatibleColumns } = await pFrameDriver.findColumns(pFrame, {\n    columnFilter: {},\n    compatibleWith: sequenceColumnsAxes.keys()\n      .map((axisIdJson) => parseJson(axisIdJson))\n      .toArray(),\n    strictlyCompatible: false,\n  });\n\n  for (const { columnId, spec } of compatibleColumns) {\n    const columnIdJson = canonicalizeJson({ type: 'column', id: columnId } satisfies PTableColumnId);\n    if (optionMap.has(columnIdJson)) continue;\n    optionMap.set(\n      columnIdJson,\n      readAnnotation(spec, Annotation.Label) ?? 'Unlabeled column',\n    );\n  }\n\n  const options = optionMap.entries()\n    .map(([value, label]) => ({ label, value: parseJson(value) }))\n    .toArray();\n\n  const defaults = options.values()\n    .filter(({ value }) => {\n      if (value.type === 'axis') return true;\n      const column = columns.find(({ columnId }) => columnId === value.id);\n      return column && isLabelColumn(column.spec);\n    })\n    .map(({ value }) => value)\n    .toArray();\n  return { options, defaults };\n}\n\nasync function getMarkupColumnsOptions({\n  pFrame,\n  sequenceColumnIds,\n}: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnIds: PObjectId[] | undefined;\n}): Promise<ListOptionNormalized<PObjectId>[] | undefined> {\n  if (!pFrame || sequenceColumnIds?.length !== 1) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n  const sequenceColumn = columns.find((column) =>\n    column.columnId === sequenceColumnIds[0],\n  );\n  if (!sequenceColumn) {\n    throw new Error(\n      `Couldn't find sequence column (ID: \\`${sequenceColumnIds[0]}\\`).`,\n    );\n  }\n  return columns.values()\n    .filter((column) =>\n      !!readAnnotationJson(column.spec, Annotation.Sequence.IsAnnotation)\n      && isJsonEqual(sequenceColumn.spec.axesSpec, column.spec.axesSpec)\n      && Object.entries(sequenceColumn.spec.domain ?? {}).every((\n        [key, value],\n      ) => column.spec.domain?.[key] === value),\n    ).map(({ columnId, spec }) => ({\n      value: columnId,\n      label: readAnnotation(spec, Annotation.Label) ?? 'Unlabeled column',\n    }))\n    .toArray();\n}\n\nasync function getMultipleAlignmentData({\n  pFrame,\n  sequenceColumnIds,\n  labelColumnIds,\n  selection,\n  colorScheme,\n  alignmentParams,\n}: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnIds: PObjectId[] | undefined;\n  labelColumnIds: PTableColumnId[] | undefined;\n  selection: PlSelectionModel | undefined;\n  colorScheme: PlMultiSequenceAlignmentColorSchemeOption;\n  alignmentParams: PlMultiSequenceAlignmentSettings['alignmentParams'];\n}): Promise<MultipleAlignmentData | undefined> {\n  if (!pFrame || !sequenceColumnIds?.length || !labelColumnIds) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n  const linkerColumns = columns.filter((column) => isLinkerColumn(column.spec));\n\n  const filterColumn = createRowSelectionColumn({ selection });\n\n  // inner join of sequence columns\n  let primaryEntry: JoinEntry<PObjectId> = {\n    type: 'inner',\n    entries: sequenceColumnIds.map((column) => ({\n      type: 'column',\n      column,\n    })),\n  };\n\n  // if we have linkers, left join them\n  if (linkerColumns.length > 0) {\n    primaryEntry = {\n      type: 'outer',\n      primary: primaryEntry,\n      secondary: linkerColumns.map(({ columnId }) => ({\n        type: 'column',\n        column: columnId,\n      })),\n    };\n  }\n\n  // inner join with filters\n  if (filterColumn) {\n    primaryEntry = {\n      type: 'inner',\n      entries: [\n        primaryEntry,\n        {\n          type: 'inlineColumn',\n          column: filterColumn,\n        },\n      ],\n    };\n  }\n\n  // left join with labels\n  const secondaryEntry: JoinEntry<PObjectId>[] = labelColumnIds\n    .flatMap((column) => {\n      if (column.type !== 'column') return [];\n      return { type: 'column', column: column.id };\n    });\n\n  // and markup\n  if (colorScheme.type === 'markup') {\n    secondaryEntry.push({ type: 'column', column: colorScheme.columnId });\n  }\n\n  const sorting: PTableSorting[] = Array.from(\n    new Set(\n      sequenceColumnIds.values().flatMap((id) => {\n        const column = columns.find(({ columnId }) => columnId === id);\n        if (!column) {\n          throw new Error(`Couldn't find sequence column (ID: ${id})`);\n        }\n        return column.spec.axesSpec\n          .map((spec) => canonicalizeJson(getAxisId(spec)));\n      }),\n    ),\n  )\n    .sort()\n    .map((id) => ({\n      column: { type: 'axis', id: parseJson(id) },\n      ascending: true,\n      naAndAbsentAreLeastValues: true,\n    }));\n\n  const request: CalculateTableDataRequest<PObjectId> = {\n    src: {\n      type: 'outer',\n      primary: primaryEntry,\n      secondary: secondaryEntry,\n    },\n    filters: [],\n    sorting,\n  };\n\n  const table = await pFrameDriver.calculateTableData(\n    pFrame,\n    JSON.parse(JSON.stringify(request)),\n    {\n      offset: 0,\n      // +1 is a hack to check whether the selection is over the limit\n      length: sequenceLimit + 1,\n    },\n  );\n\n  let rowCount = table?.[0].data.data.length ?? 0;\n  let exceedsLimit = false;\n  if (rowCount > sequenceLimit) {\n    rowCount = sequenceLimit;\n    exceedsLimit = true;\n  }\n\n  const sequenceColumns = sequenceColumnIds.map((columnId) => {\n    const column = table.find(({ spec }) => spec.id === columnId);\n    if (!column) {\n      throw new Error(`Couldn't find sequence column (ID: \\`${columnId}\\`).`);\n    }\n    return column;\n  });\n\n  const labelColumns = labelColumnIds.map((labelColumn) => {\n    const column = table.find(({ spec }) => {\n      if (labelColumn.type === 'axis' && spec.type === 'axis') {\n        return isJsonEqual(labelColumn.id, spec.id);\n      }\n      if (labelColumn.type === 'column' && spec.type === 'column') {\n        return labelColumn.id === spec.id;\n      }\n    });\n    if (!column) {\n      throw new Error(`Couldn't find label column (ID: \\`${labelColumn}\\`).`);\n    }\n    return column;\n  });\n\n  const alignedSequences = await Promise.all(\n    sequenceColumns.map((column) =>\n      multiSequenceAlignment(\n        Array.from(\n          { length: rowCount },\n          (_, row) =>\n            pTableValue(column.data, row, { na: '', absent: '' })?.toString()\n            ?? '',\n        ),\n        alignmentParams,\n      ),\n    ),\n  );\n\n  const sequences = Array.from(\n    { length: rowCount },\n    (_, row) => alignedSequences.map((column) => column[row]),\n  );\n\n  const sequenceNames = sequenceColumns.map((column) =>\n    readAnnotation(column.spec.spec, Annotation.Label) ?? 'Unlabeled column',\n  );\n\n  const labels = Array.from(\n    { length: rowCount },\n    (_, row) =>\n      labelColumns.map((column) =>\n        pTableValue(column.data, row, { na: '', absent: '' })?.toString() ?? '',\n      ),\n  );\n\n  const concatenatedSequences = sequences.map((row) => row.join(' '));\n  const residueCounts = getResidueCounts(concatenatedSequences);\n\n  const result: MultipleAlignmentData = {\n    sequences: concatenatedSequences,\n    sequenceNames,\n    labelRows: labels,\n    exceedsLimit,\n    residueCounts,\n  };\n\n  if (colorScheme.type === 'chemical-properties') {\n    result.highlightImage = highlightByChemicalProperties({\n      sequences: concatenatedSequences,\n      residueCounts,\n    });\n  } else if (colorScheme.type === 'markup') {\n    const markupColumn = table.find(({ spec }) =>\n      spec.id === colorScheme.columnId,\n    );\n    if (!markupColumn) {\n      throw new Error(\n        `Couldn't find markup column (ID: \\`${colorScheme.columnId}\\`).`,\n      );\n    }\n    const markupRows = Array.from(\n      { length: rowCount },\n      (_, row) => {\n        const markup = parseMarkup(\n          pTableValue(markupColumn.data, row, { na: '', absent: '' })\n            ?.toString()\n            ?? '',\n        );\n        return markupAlignedSequence(sequences[row][0], markup);\n      },\n    );\n    const labels = readAnnotationJson(markupColumn.spec.spec, Annotation.Sequence.Annotation.Mapping) ?? {};\n    result.highlightImage = highlightByMarkup({\n      markupRows,\n      columnCount: concatenatedSequences.at(0)?.length ?? 0,\n      labels,\n    });\n  }\n\n  return result;\n}\n\nfunction refreshOnDeepChange<T, P>(cb: (params: P) => Promise<T>) {\n  const data = ref<T>();\n  const isLoading = ref(true);\n  const error = ref<Error>();\n  let requestId: symbol;\n  return (paramsGetter: () => P) => {\n    watch(paramsGetter, async (params, prevParams) => {\n      if (isJsonEqual(params, prevParams)) return;\n      const currentRequestId = requestId = Symbol();\n      try {\n        error.value = undefined;\n        isLoading.value = true;\n        const result = await cb(params);\n        if (currentRequestId === requestId) {\n          data.value = result;\n        }\n      } catch (err) {\n        console.error(err);\n        if (currentRequestId === requestId) {\n          error.value = ensureError(err);\n        }\n      } finally {\n        if (currentRequestId === requestId) {\n          isLoading.value = false;\n        }\n      }\n    }, { immediate: true });\n    return { data, isLoading, error };\n  };\n}\n\ntype MultipleAlignmentData = {\n  sequences: string[];\n  sequenceNames: string[];\n  labelRows: string[][];\n  residueCounts: ResidueCounts;\n  highlightImage?: {\n    blob: Blob;\n    legend: HighlightLegend;\n  };\n  exceedsLimit: boolean;\n};\n\ntype OptionsWithDefaults<T> = {\n  options: ListOptionNormalized<T>[];\n  defaults: T[];\n};\n"],"names":["getPFrameDriver","getRawPlatformaInstance","sequenceLimit","useSequenceColumnsOptions","refreshOnDeepChange","getSequenceColumnsOptions","useLabelColumnsOptions","getLabelColumnsOptions","useMarkupColumnsOptions","getMarkupColumnsOptions","useMultipleAlignmentData","getMultipleAlignmentData","pFrame","sequenceColumnPredicate","options","column","spec","columnId","readAnnotation","Annotation","defaults","value","sequenceColumnIds","pFrameDriver","columns","optionMap","sequenceColumnsAxes","id","canonicalizeJson","getAxisId","axisIdJson","axisSpec","axisId","parseJson","labelColumn","isLabelColumn","matchAxisId","compatibleColumns","columnIdJson","label","sequenceColumn","readAnnotationJson","isJsonEqual","key","_a","labelColumnIds","selection","colorScheme","alignmentParams","linkerColumns","isLinkerColumn","filterColumn","createRowSelectionColumn","primaryEntry","secondaryEntry","sorting","request","table","rowCount","exceedsLimit","sequenceColumns","labelColumns","alignedSequences","multiSequenceAlignment","_","row","pTableValue","sequences","sequenceNames","labels","concatenatedSequences","residueCounts","getResidueCounts","result","highlightByChemicalProperties","markupColumn","markupRows","markup","parseMarkup","markupAlignedSequence","highlightByMarkup","cb","data","ref","isLoading","error","requestId","paramsGetter","watch","params","prevParams","currentRequestId","err","ensureError"],"mappings":";;;;;;;;AAuCA,MAAMA,IAAkB,MAAMC,EAAA,EAA0B,cAE3CC,IAAgB,KAEhBC,KAA4BC;AAAA,EACvCC;AACF,GAEaC,KAAyBF;AAAA,EACpCG;AACF,GAEaC,KAA0BJ;AAAA,EACrCK;AACF,GAEaC,KAA2BN;AAAA,EACtCO;AACF;AAEA,eAAeN,GAA0B;AAAA,EACvC,QAAAO;AAAA,EACA,yBAAAC;AACF,GAGwD;AACtD,MAAI,CAACD,EAAQ;AAIb,QAAME,KADU,MADKd,EAAA,EACc,YAAYY,CAAM,GAC7B,OAAA,EACrB,OAAO,CAACG,MAAWF,EAAwBE,CAAM,CAAC,EAClD,IAAI,CAAC,EAAE,MAAAC,GAAM,UAAAC,SAAgB;AAAA,IAC5B,OAAOC,EAAeF,GAAMG,EAAW,KAAK,KAAK;AAAA,IACjD,OAAOF;AAAA,EAAA,EACP,EACD,QAAA,GACGG,IAAWN,EAAQ,IAAI,CAAC,EAAE,OAAAO,EAAA,MAAYA,CAAK;AACjD,SAAO,EAAE,SAAAP,GAAS,UAAAM,EAAA;AACpB;AAEA,eAAeb,GAAuB;AAAA,EACpC,QAAAK;AAAA,EACA,mBAAAU;AACF,GAG6D;AAC3D,MAAI,CAACV,KAAU,CAACU,EAAmB;AAEnC,QAAMC,IAAevB,EAAA,GACfwB,IAAU,MAAMD,EAAa,YAAYX,CAAM,GAC/Ca,wBAAgB,IAAA,GAEhBC,IAAsB,IAAI;AAAA,IAC9BJ,EAAkB,OAAA,EAAS,QAAQ,CAACK,MAAO;AACzC,YAAMZ,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,EAAA,MAAeA,MAAaU,CAAE;AAC7D,UAAI,CAACZ;AACH,cAAM,IAAI,MAAM,wCAAwCY,CAAE,MAAM;AAElE,aAAOZ,EAAO,KAAK,SAAS,OAAA,EACzB,IAAI,CAACC,MAAS,CAACY,EAAiBC,EAAUb,CAAI,CAAC,GAAGA,CAAI,CAAC;AAAA,IAC5D,CAAC;AAAA,EAAA;AAGH,aAAW,CAACc,GAAYC,CAAQ,KAAKL,EAAoB,WAAW;AAClE,UAAMM,IAASC,EAAUH,CAAU,GAC7BI,IAAcV,EAAQ;AAAA,MAAK,CAAC,EAAE,MAAAR,EAAA,MAClCmB,EAAcnB,CAAI,KAAKoB,EAAYJ,GAAQH,EAAUb,EAAK,SAAS,CAAC,CAAC,CAAC;AAAA,IAAA;AAExE,IAAAS,EAAU;AAAA,MACRS,IACIN,EAAiB,EAAE,MAAM,UAAU,IAAIM,EAAY,SAAA,CAAU,IAC7DN,EAAiB,EAAE,MAAM,QAAQ,IAAII,GAAQ;AAAA,MACjDd,EAAegB,KAAA,gBAAAA,EAAa,MAAMf,EAAW,KAAK,KAC/CD,EAAea,GAAUZ,EAAW,KAAK,KACzC;AAAA,IAAA;AAAA,EAEP;AAEA,QAAM,EAAE,MAAMkB,EAAA,IAAsB,MAAMd,EAAa,YAAYX,GAAQ;AAAA,IACzE,cAAc,CAAA;AAAA,IACd,gBAAgBc,EAAoB,KAAA,EACjC,IAAI,CAACI,MAAeG,EAAUH,CAAU,CAAC,EACzC,QAAA;AAAA,IACH,oBAAoB;AAAA,EAAA,CACrB;AAED,aAAW,EAAE,UAAAb,GAAU,MAAAD,EAAA,KAAUqB,GAAmB;AAClD,UAAMC,IAAeV,EAAiB,EAAE,MAAM,UAAU,IAAIX,GAAmC;AAC/F,IAAIQ,EAAU,IAAIa,CAAY,KAC9Bb,EAAU;AAAA,MACRa;AAAA,MACApB,EAAeF,GAAMG,EAAW,KAAK,KAAK;AAAA,IAAA;AAAA,EAE9C;AAEA,QAAML,IAAUW,EAAU,QAAA,EACvB,IAAI,CAAC,CAACJ,GAAOkB,CAAK,OAAO,EAAE,OAAAA,GAAO,OAAON,EAAUZ,CAAK,EAAA,EAAI,EAC5D,QAAA,GAEGD,IAAWN,EAAQ,OAAA,EACtB,OAAO,CAAC,EAAE,OAAAO,QAAY;AACrB,QAAIA,EAAM,SAAS,OAAQ,QAAO;AAClC,UAAMN,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,QAAeA,MAAaI,EAAM,EAAE;AACnE,WAAON,KAAUoB,EAAcpB,EAAO,IAAI;AAAA,EAC5C,CAAC,EACA,IAAI,CAAC,EAAE,OAAAM,EAAA,MAAYA,CAAK,EACxB,QAAA;AACH,SAAO,EAAE,SAAAP,GAAS,UAAAM,EAAA;AACpB;AAEA,eAAeX,GAAwB;AAAA,EACrC,QAAAG;AAAA,EACA,mBAAAU;AACF,GAG2D;AACzD,MAAI,CAACV,MAAUU,KAAA,gBAAAA,EAAmB,YAAW,EAAG;AAGhD,QAAME,IAAU,MADKxB,EAAA,EACc,YAAYY,CAAM,GAC/C4B,IAAiBhB,EAAQ;AAAA,IAAK,CAACT,MACnCA,EAAO,aAAaO,EAAkB,CAAC;AAAA,EAAA;AAEzC,MAAI,CAACkB;AACH,UAAM,IAAI;AAAA,MACR,wCAAwClB,EAAkB,CAAC,CAAC;AAAA,IAAA;AAGhE,SAAOE,EAAQ,SACZ;AAAA,IAAO,CAACT,MACP,CAAC,CAAC0B,EAAmB1B,EAAO,MAAMI,EAAW,SAAS,YAAY,KAC/DuB,EAAYF,EAAe,KAAK,UAAUzB,EAAO,KAAK,QAAQ,KAC9D,OAAO,QAAQyB,EAAe,KAAK,UAAU,CAAA,CAAE,EAAE,MAAM,CACxD,CAACG,GAAKtB,CAAK,MAAA;;AACR,eAAAuB,IAAA7B,EAAO,KAAK,WAAZ,gBAAA6B,EAAqBD,QAAStB;AAAA,KAAK;AAAA,EAAA,EACxC,IAAI,CAAC,EAAE,UAAAJ,GAAU,MAAAD,SAAY;AAAA,IAC7B,OAAOC;AAAA,IACP,OAAOC,EAAeF,GAAMG,EAAW,KAAK,KAAK;AAAA,EAAA,EACjD,EACD,QAAA;AACL;AAEA,eAAeR,GAAyB;AAAA,EACtC,QAAAC;AAAA,EACA,mBAAAU;AAAA,EACA,gBAAAuB;AAAA,EACA,WAAAC;AAAA,EACA,aAAAC;AAAA,EACA,iBAAAC;AACF,GAO+C;;AAC7C,MAAI,CAACpC,KAAU,EAACU,KAAA,QAAAA,EAAmB,WAAU,CAACuB,EAAgB;AAE9D,QAAMtB,IAAevB,EAAA,GACfwB,IAAU,MAAMD,EAAa,YAAYX,CAAM,GAC/CqC,IAAgBzB,EAAQ,OAAO,CAACT,MAAWmC,EAAenC,EAAO,IAAI,CAAC,GAEtEoC,IAAeC,EAAyB,EAAE,WAAAN,GAAW;AAG3D,MAAIO,IAAqC;AAAA,IACvC,MAAM;AAAA,IACN,SAAS/B,EAAkB,IAAI,CAACP,OAAY;AAAA,MAC1C,MAAM;AAAA,MACN,QAAAA;AAAA,IAAA,EACA;AAAA,EAAA;AAIJ,EAAIkC,EAAc,SAAS,MACzBI,IAAe;AAAA,IACb,MAAM;AAAA,IACN,SAASA;AAAA,IACT,WAAWJ,EAAc,IAAI,CAAC,EAAE,UAAAhC,SAAgB;AAAA,MAC9C,MAAM;AAAA,MACN,QAAQA;AAAA,IAAA,EACR;AAAA,EAAA,IAKFkC,MACFE,IAAe;AAAA,IACb,MAAM;AAAA,IACN,SAAS;AAAA,MACPA;AAAA,MACA;AAAA,QACE,MAAM;AAAA,QACN,QAAQF;AAAA,MAAA;AAAA,IACV;AAAA,EACF;AAKJ,QAAMG,IAAyCT,EAC5C,QAAQ,CAAC9B,MACJA,EAAO,SAAS,WAAiB,CAAA,IAC9B,EAAE,MAAM,UAAU,QAAQA,EAAO,GAAA,CACzC;AAGH,EAAIgC,EAAY,SAAS,YACvBO,EAAe,KAAK,EAAE,MAAM,UAAU,QAAQP,EAAY,UAAU;AAGtE,QAAMQ,IAA2B,MAAM;AAAA,IACrC,IAAI;AAAA,MACFjC,EAAkB,OAAA,EAAS,QAAQ,CAACK,MAAO;AACzC,cAAMZ,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,EAAA,MAAeA,MAAaU,CAAE;AAC7D,YAAI,CAACZ;AACH,gBAAM,IAAI,MAAM,sCAAsCY,CAAE,GAAG;AAE7D,eAAOZ,EAAO,KAAK,SAChB,IAAI,CAACC,MAASY,EAAiBC,EAAUb,CAAI,CAAC,CAAC;AAAA,MACpD,CAAC;AAAA,IAAA;AAAA,EACH,EAEC,KAAA,EACA,IAAI,CAACW,OAAQ;AAAA,IACZ,QAAQ,EAAE,MAAM,QAAQ,IAAIM,EAAUN,CAAE,EAAA;AAAA,IACxC,WAAW;AAAA,IACX,2BAA2B;AAAA,EAAA,EAC3B,GAEE6B,IAAgD;AAAA,IACpD,KAAK;AAAA,MACH,MAAM;AAAA,MACN,SAASH;AAAA,MACT,WAAWC;AAAA,IAAA;AAAA,IAEb,SAAS,CAAA;AAAA,IACT,SAAAC;AAAA,EAAA,GAGIE,IAAQ,MAAMlC,EAAa;AAAA,IAC/BX;AAAA,IACA,KAAK,MAAM,KAAK,UAAU4C,CAAO,CAAC;AAAA,IAClC;AAAA,MACE,QAAQ;AAAA;AAAA,MAER,QAAQtD,IAAgB;AAAA,IAAA;AAAA,EAC1B;AAGF,MAAIwD,KAAWD,KAAA,gBAAAA,EAAQ,GAAG,KAAK,KAAK,WAAU,GAC1CE,IAAe;AACnB,EAAID,IAAWxD,MACbwD,IAAWxD,GACXyD,IAAe;AAGjB,QAAMC,IAAkBtC,EAAkB,IAAI,CAACL,MAAa;AAC1D,UAAMF,IAAS0C,EAAM,KAAK,CAAC,EAAE,MAAAzC,QAAWA,EAAK,OAAOC,CAAQ;AAC5D,QAAI,CAACF;AACH,YAAM,IAAI,MAAM,wCAAwCE,CAAQ,MAAM;AAExE,WAAOF;AAAA,EACT,CAAC,GAEK8C,IAAehB,EAAe,IAAI,CAACX,MAAgB;AACvD,UAAMnB,IAAS0C,EAAM,KAAK,CAAC,EAAE,MAAAzC,QAAW;AACtC,UAAIkB,EAAY,SAAS,UAAUlB,EAAK,SAAS;AAC/C,eAAO0B,EAAYR,EAAY,IAAIlB,EAAK,EAAE;AAE5C,UAAIkB,EAAY,SAAS,YAAYlB,EAAK,SAAS;AACjD,eAAOkB,EAAY,OAAOlB,EAAK;AAAA,IAEnC,CAAC;AACD,QAAI,CAACD;AACH,YAAM,IAAI,MAAM,qCAAqCmB,CAAW,MAAM;AAExE,WAAOnB;AAAA,EACT,CAAC,GAEK+C,IAAmB,MAAM,QAAQ;AAAA,IACrCF,EAAgB;AAAA,MAAI,CAAC7C,MACnBgD;AAAA,QACE,MAAM;AAAA,UACJ,EAAE,QAAQL,EAAA;AAAA,UACV,CAACM,GAAGC,MAAA;;AACF,qBAAArB,IAAAsB,EAAYnD,EAAO,MAAMkD,GAAK,EAAE,IAAI,IAAI,QAAQ,GAAA,CAAI,MAApD,gBAAArB,EAAuD,eACpD;AAAA;AAAA,QAAA;AAAA,QAEPI;AAAA,MAAA;AAAA,IACF;AAAA,EACF,GAGImB,IAAY,MAAM;AAAA,IACtB,EAAE,QAAQT,EAAA;AAAA,IACV,CAACM,GAAGC,MAAQH,EAAiB,IAAI,CAAC/C,MAAWA,EAAOkD,CAAG,CAAC;AAAA,EAAA,GAGpDG,IAAgBR,EAAgB;AAAA,IAAI,CAAC7C,MACzCG,EAAeH,EAAO,KAAK,MAAMI,EAAW,KAAK,KAAK;AAAA,EAAA,GAGlDkD,IAAS,MAAM;AAAA,IACnB,EAAE,QAAQX,EAAA;AAAA,IACV,CAACM,GAAGC,MACFJ,EAAa;AAAA,MAAI,CAAC9C,MAAA;;AAChB,iBAAA6B,IAAAsB,EAAYnD,EAAO,MAAMkD,GAAK,EAAE,IAAI,IAAI,QAAQ,IAAI,MAApD,gBAAArB,EAAuD,eAAc;AAAA;AAAA,IAAA;AAAA,EACvE,GAGE0B,IAAwBH,EAAU,IAAI,CAACF,MAAQA,EAAI,KAAK,GAAG,CAAC,GAC5DM,IAAgBC,GAAiBF,CAAqB,GAEtDG,IAAgC;AAAA,IACpC,WAAWH;AAAA,IACX,eAAAF;AAAA,IACA,WAAWC;AAAA,IACX,cAAAV;AAAA,IACA,eAAAY;AAAA,EAAA;AAGF,MAAIxB,EAAY,SAAS;AACvB,IAAA0B,EAAO,iBAAiBC,EAA8B;AAAA,MACpD,WAAWJ;AAAA,MACX,eAAAC;AAAA,IAAA,CACD;AAAA,WACQxB,EAAY,SAAS,UAAU;AACxC,UAAM4B,IAAelB,EAAM;AAAA,MAAK,CAAC,EAAE,MAAAzC,EAAA,MACjCA,EAAK,OAAO+B,EAAY;AAAA,IAAA;AAE1B,QAAI,CAAC4B;AACH,YAAM,IAAI;AAAA,QACR,sCAAsC5B,EAAY,QAAQ;AAAA,MAAA;AAG9D,UAAM6B,IAAa,MAAM;AAAA,MACvB,EAAE,QAAQlB,EAAA;AAAA,MACV,CAACM,GAAGC,MAAQ;;AACV,cAAMY,IAASC;AAAA,YACblC,IAAAsB,EAAYS,EAAa,MAAMV,GAAK,EAAE,IAAI,IAAI,QAAQ,IAAI,MAA1D,gBAAArB,EACI,eACC;AAAA,QAAA;AAEP,eAAOmC,GAAsBZ,EAAUF,CAAG,EAAE,CAAC,GAAGY,CAAM;AAAA,MACxD;AAAA,IAAA,GAEIR,IAAS5B,EAAmBkC,EAAa,KAAK,MAAMxD,EAAW,SAAS,WAAW,OAAO,KAAK,CAAA;AACrG,IAAAsD,EAAO,iBAAiBO,GAAkB;AAAA,MACxC,YAAAJ;AAAA,MACA,eAAahC,IAAA0B,EAAsB,GAAG,CAAC,MAA1B,gBAAA1B,EAA6B,WAAU;AAAA,MACpD,QAAAyB;AAAAA,IAAA,CACD;AAAA,EACH;AAEA,SAAOI;AACT;AAEA,SAASrE,EAA0B6E,GAA+B;AAChE,QAAMC,IAAOC,EAAA,GACPC,IAAYD,EAAI,EAAI,GACpBE,IAAQF,EAAA;AACd,MAAIG;AACJ,SAAO,CAACC,OACNC,EAAMD,GAAc,OAAOE,GAAQC,MAAe;AAChD,QAAIhD,EAAY+C,GAAQC,CAAU,EAAG;AACrC,UAAMC,IAAmBL,IAAY,OAAA;AACrC,QAAI;AACF,MAAAD,EAAM,QAAQ,QACdD,EAAU,QAAQ;AAClB,YAAMX,IAAS,MAAMQ,EAAGQ,CAAM;AAC9B,MAAIE,MAAqBL,MACvBJ,EAAK,QAAQT;AAAA,IAEjB,SAASmB,GAAK;AACZ,cAAQ,MAAMA,CAAG,GACbD,MAAqBL,MACvBD,EAAM,QAAQQ,EAAYD,CAAG;AAAA,IAEjC,UAAA;AACE,MAAID,MAAqBL,MACvBF,EAAU,QAAQ;AAAA,IAEtB;AAAA,EACF,GAAG,EAAE,WAAW,IAAM,GACf,EAAE,MAAAF,GAAM,WAAAE,GAAW,OAAAC,EAAA;AAE9B;"}
+{"version":3,"file":"data.js","sources":["../../../src/components/PlMultiSequenceAlignment/data.ts"],"sourcesContent":["import { isJsonEqual } from '@milaboratories/helpers';\nimport type { ListOptionNormalized } from '@milaboratories/uikit';\nimport {\n  Annotation,\n  type CalculateTableDataRequest,\n  type CalculateTableDataResponse,\n  type CanonicalizedJson,\n  canonicalizeJson,\n  createRowSelectionColumn,\n  ensureError,\n  getAxisId,\n  getRawPlatformaInstance,\n  isLabelColumn,\n  isLinkerColumn,\n  type JoinEntry,\n  matchAxisId,\n  parseJson,\n  type PColumnIdAndSpec,\n  type PFrameHandle,\n  type PlMultiSequenceAlignmentColorSchemeOption,\n  type PlMultiSequenceAlignmentSettings,\n  type PlSelectionModel,\n  type PObjectId,\n  type PTableColumnId,\n  type PTableSorting,\n  pTableValue,\n  readAnnotation,\n  readAnnotationJson,\n} from '@platforma-sdk/model';\nimport { onWatcherCleanup, ref, watch } from 'vue';\nimport { objectHash } from '../../objectHash';\nimport { highlightByChemicalProperties } from './chemical-properties';\nimport type { Markup } from './markup';\nimport {\n  highlightByMarkup,\n  markupAlignedSequence,\n  parseMarkup,\n} from './markup';\nimport type * as MultiSequenceAlignmentWorker from './multi-sequence-alignment.worker';\nimport type * as PhylogeneticTreeWorker from './phylogenetic-tree.worker';\nimport { getResidueCounts } from './residue-counts';\nimport type { HighlightLegend, ResidueCounts } from './types';\n\nconst getPFrameDriver = () => getRawPlatformaInstance().pFrameDriver;\n\nexport const SEQUENCE_LIMIT = 1000;\n\nexport const useSequenceColumnsOptions = refreshOnDeepChange(\n  getSequenceColumnsOptions,\n);\n\nexport const useLabelColumnsOptions = refreshOnDeepChange(\n  getLabelColumnsOptions,\n);\n\nexport const useMarkupColumnsOptions = refreshOnDeepChange(\n  getMarkupColumnsOptions,\n);\n\nexport const useMultipleAlignmentData = refreshOnDeepChange(\n  getMultipleAlignmentData,\n);\n\nasync function getSequenceColumnsOptions({ pFrame, sequenceColumnPredicate }: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnPredicate: (column: PColumnIdAndSpec) => boolean;\n}): Promise<OptionsWithDefaults<PObjectId> | undefined> {\n  if (!pFrame) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n\n  const options = columns.values()\n    .filter((column) => sequenceColumnPredicate(column))\n    .map(({ spec, columnId }) => ({\n      label: readAnnotation(spec, Annotation.Label) ?? 'Unlabeled column',\n      value: columnId,\n    }))\n    .toArray();\n\n  const defaults = options.map(({ value }) => value);\n\n  return { options, defaults };\n}\n\nasync function getLabelColumnsOptions({ pFrame, sequenceColumnIds }: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnIds: PObjectId[] | undefined;\n}): Promise<OptionsWithDefaults<PTableColumnId> | undefined> {\n  if (!pFrame || !sequenceColumnIds) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n\n  const sequenceColumnsAxes = new Map(\n    sequenceColumnIds.values().flatMap((id) => {\n      const column = columns.find(({ columnId }) => columnId === id);\n      if (!column) {\n        throw new Error(`Couldn't find sequence column (ID: \\`${id}\\`).`);\n      }\n      return column.spec.axesSpec.values()\n        .map((spec) => [canonicalizeJson(getAxisId(spec)), spec]);\n    }),\n  );\n\n  const optionMap = new Map<CanonicalizedJson<PTableColumnId>, string>();\n  for (const [axisIdJson, axisSpec] of sequenceColumnsAxes.entries()) {\n    const axisId = parseJson(axisIdJson);\n    const labelColumn = columns.find(({ spec }) =>\n      isLabelColumn(spec) && matchAxisId(axisId, getAxisId(spec.axesSpec[0])),\n    );\n    optionMap.set(\n      labelColumn\n        ? canonicalizeJson({ type: 'column', id: labelColumn.columnId })\n        : canonicalizeJson({ type: 'axis', id: axisId }),\n      readAnnotation(labelColumn?.spec, Annotation.Label)\n      ?? readAnnotation(axisSpec, Annotation.Label)\n      ?? 'Unlabeled axis',\n    );\n  }\n\n  const { hits: compatibleColumns } = await pFrameDriver.findColumns(pFrame, {\n    columnFilter: {},\n    compatibleWith: sequenceColumnsAxes.keys()\n      .map((axisIdJson) => parseJson(axisIdJson))\n      .toArray(),\n    strictlyCompatible: false,\n  });\n\n  for (const { columnId, spec } of compatibleColumns) {\n    const columnIdJson = canonicalizeJson<PTableColumnId>({\n      type: 'column',\n      id: columnId,\n    });\n    if (optionMap.has(columnIdJson)) continue;\n    optionMap.set(\n      columnIdJson,\n      readAnnotation(spec, Annotation.Label) ?? 'Unlabeled column',\n    );\n  }\n\n  const options = optionMap.entries()\n    .map(([value, label]) => ({ label, value: parseJson(value) }))\n    .toArray();\n\n  const defaults = options.values()\n    .filter(({ value }) => {\n      if (value.type === 'axis') return true;\n      const column = columns.find(({ columnId }) => columnId === value.id);\n      return column && isLabelColumn(column.spec);\n    })\n    .map(({ value }) => value)\n    .toArray();\n\n  return { options, defaults };\n}\n\nasync function getMarkupColumnsOptions({ pFrame, sequenceColumnIds }: {\n  pFrame: PFrameHandle | undefined;\n  sequenceColumnIds: PObjectId[] | undefined;\n}): Promise<ListOptionNormalized<PObjectId[]>[] | undefined> {\n  if (!pFrame || !sequenceColumnIds) return;\n\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n\n  const sequenceColumns = sequenceColumnIds.map((columnId) => {\n    const column = columns.find((column) => column.columnId === columnId);\n    if (!column) {\n      throw new Error(\n        `Couldn't find sequence column (ID: \\`${sequenceColumnIds[0]}\\`).`,\n      );\n    }\n    return column;\n  });\n\n  const columnPairs = sequenceColumns\n    .flatMap((sequenceColumn) =>\n      columns\n        .filter((column) =>\n          readAnnotationJson(column.spec, Annotation.Sequence.IsAnnotation)\n          && isJsonEqual(sequenceColumn.spec.axesSpec, column.spec.axesSpec)\n          && Object.entries(sequenceColumn.spec.domain ?? {})\n            .every(([key, value]) => column.spec.domain?.[key] === value),\n        )\n        .map((markupColumn) => ({ markupColumn, sequenceColumn })),\n    );\n\n  const groupedByDomainDiff = Map.groupBy(\n    columnPairs,\n    ({ markupColumn, sequenceColumn }) => {\n      const domainDiff = Object.fromEntries(\n        Object.entries(markupColumn.spec.domain ?? {})\n          .filter(([key]) => sequenceColumn.spec.domain?.[key] == undefined),\n      );\n      return canonicalizeJson(domainDiff);\n    },\n  );\n\n  return groupedByDomainDiff.entries()\n    .map(([domainDiffJson, columnPairs]) => ({\n      label: Object.values(parseJson(domainDiffJson)).join(', '),\n      value: columnPairs.map(({ markupColumn }) => markupColumn.columnId),\n    }))\n    .toArray();\n}\n\nasync function getMultipleAlignmentData(\n  {\n    pFrame,\n    sequenceColumnIds,\n    labelColumnIds,\n    selection,\n    colorScheme,\n    alignmentParams,\n    shouldBuildPhylogeneticTree,\n  }: {\n    pFrame: PFrameHandle | undefined;\n    sequenceColumnIds: PObjectId[] | undefined;\n    labelColumnIds: PTableColumnId[] | undefined;\n    selection: PlSelectionModel | undefined;\n    colorScheme: PlMultiSequenceAlignmentColorSchemeOption;\n    alignmentParams: PlMultiSequenceAlignmentSettings['alignmentParams'];\n    shouldBuildPhylogeneticTree: boolean;\n  },\n  abortSignal: AbortSignal,\n): Promise<MultipleAlignmentData | undefined> {\n  if (!pFrame || !sequenceColumnIds?.length || !labelColumnIds) return;\n\n  const table = await getTableData({\n    pFrame,\n    sequenceColumnIds,\n    labelColumnIds,\n    selection,\n    colorScheme,\n  });\n\n  const rowCount = table.at(0)?.data.data.length ?? 0;\n\n  if (rowCount < 2) return;\n\n  const exceedsLimit = rowCount > SEQUENCE_LIMIT;\n  const rawSequences = extractSequences(sequenceColumnIds, table);\n  const labels = extractLabels(labelColumnIds, table);\n  const markups = colorScheme.type === 'markup'\n    ? extractMarkups(colorScheme.columnIds, table)\n    : undefined;\n\n  const highlightLegend: HighlightLegend = {};\n\n  const alignedSequences = await Promise.all(\n    rawSequences.map(async ({ name, rows }) => ({\n      name,\n      rows: await alignSequences(\n        rows,\n        JSON.parse(JSON.stringify(alignmentParams)),\n        abortSignal,\n      ),\n    })),\n  );\n\n  let phylogeneticTree: PhylogeneticTreeWorker.TreeNodeData[] | undefined;\n  if (shouldBuildPhylogeneticTree) {\n    phylogeneticTree = await buildPhylogeneticTree(\n      alignedSequences,\n      abortSignal,\n    );\n    const rowOrder = phylogeneticTree.values()\n      .filter(({ id }) => id >= 0)\n      .map(({ id }) => id)\n      .toArray();\n    for (const sequencesColumn of alignedSequences) {\n      sequencesColumn.rows = rowOrder.map((i) => sequencesColumn.rows[i]);\n    }\n    for (const labelsColumn of labels) {\n      labelsColumn.rows = rowOrder.map((i) => labelsColumn.rows[i]);\n    }\n    for (const markupsColumn of markups ?? []) {\n      markupsColumn.rows = rowOrder.map((i) => markupsColumn.rows[i]);\n    }\n  }\n\n  const sequences = await Promise.all(\n    alignedSequences.map(async ({ name, rows }, index) => {\n      const residueCounts = getResidueCounts(rows);\n      const image = generateHighlightImage({\n        colorScheme,\n        sequences: rows,\n        residueCounts,\n        markup: markups?.at(index),\n      });\n      if (image) {\n        Object.assign(highlightLegend, image.legend);\n      }\n      return {\n        name,\n        rows,\n        residueCounts,\n        ...image && {\n          highlightImageUrl: await blobToBase64(image.blob),\n        },\n      } satisfies MultipleAlignmentData['sequences'][number];\n    }),\n  );\n\n  return {\n    sequences,\n    labels,\n    ...Object.keys(highlightLegend).length && {\n      highlightLegend,\n    },\n    ...phylogeneticTree && {\n      phylogeneticTree,\n    },\n    exceedsLimit,\n  };\n}\n\nasync function getTableData(\n  { pFrame, sequenceColumnIds, labelColumnIds, selection, colorScheme }: {\n    pFrame: PFrameHandle;\n    sequenceColumnIds: PObjectId[];\n    labelColumnIds: PTableColumnId[];\n    selection: PlSelectionModel | undefined;\n    colorScheme: PlMultiSequenceAlignmentColorSchemeOption;\n  },\n): Promise<CalculateTableDataResponse> {\n  const pFrameDriver = getPFrameDriver();\n  const columns = await pFrameDriver.listColumns(pFrame);\n  const linkerColumns = columns.filter((column) => isLinkerColumn(column.spec));\n\n  const filterColumn = createRowSelectionColumn({ selection });\n\n  // inner join of sequence columns\n  let primaryEntry: JoinEntry<PObjectId> = {\n    type: 'inner',\n    entries: sequenceColumnIds.map((column) => ({\n      type: 'column',\n      column,\n    })),\n  };\n\n  // if we have linkers, left join them\n  if (linkerColumns.length > 0) {\n    primaryEntry = {\n      type: 'outer',\n      primary: primaryEntry,\n      secondary: linkerColumns.map(({ columnId }) => ({\n        type: 'column',\n        column: columnId,\n      })),\n    };\n  }\n\n  // inner join with filters\n  if (filterColumn) {\n    primaryEntry = {\n      type: 'inner',\n      entries: [\n        primaryEntry,\n        {\n          type: 'inlineColumn',\n          column: filterColumn,\n        },\n      ],\n    };\n  }\n\n  // left join with labels\n  const secondaryEntry: JoinEntry<PObjectId>[] = labelColumnIds\n    .flatMap((column) => {\n      if (column.type !== 'column') return [];\n      return { type: 'column', column: column.id };\n    });\n\n  // and markup\n  if (colorScheme.type === 'markup') {\n    for (const column of colorScheme.columnIds) {\n      secondaryEntry.push({ type: 'column', column });\n    }\n  }\n\n  const sorting: PTableSorting[] = Array.from(\n    new Set(\n      sequenceColumnIds.values().flatMap((id) => {\n        const column = columns.find(({ columnId }) => columnId === id);\n        if (!column) {\n          throw new Error(`Couldn't find sequence column (ID: ${id})`);\n        }\n        return column.spec.axesSpec\n          .map((spec) => canonicalizeJson(getAxisId(spec)));\n      }),\n    ),\n  )\n    .sort()\n    .map((id) => ({\n      column: { type: 'axis', id: parseJson(id) },\n      ascending: true,\n      naAndAbsentAreLeastValues: true,\n    }));\n\n  const request: CalculateTableDataRequest<PObjectId> = {\n    src: {\n      type: 'outer',\n      primary: primaryEntry,\n      secondary: secondaryEntry,\n    },\n    filters: [],\n    sorting,\n  };\n\n  return pFrameDriver.calculateTableData(\n    pFrame,\n    JSON.parse(JSON.stringify(request)),\n    {\n      offset: 0,\n      // +1 is a hack to check whether the selection is over the limit\n      length: SEQUENCE_LIMIT + 1,\n    },\n  );\n}\n\nconst extractSequences = (\n  columnIds: PObjectId[],\n  table: CalculateTableDataResponse,\n): { name: string; rows: string[] }[] =>\n  columnIds.map((columnId) => {\n    const column = table.find(({ spec }) => spec.id === columnId);\n    if (!column) {\n      throw new Error(`Couldn't find sequence column (ID: \\`${columnId}\\`).`);\n    }\n    const name = readAnnotation(column.spec.spec, Annotation.Label)\n      ?? 'Unlabeled column';\n    const rows = column.data.data\n      .keys()\n      .take(SEQUENCE_LIMIT)\n      .map((row) =>\n        pTableValue(column.data, row, { absent: '', na: '' })?.toString()\n        ?? '',\n      )\n      .toArray();\n    return { name, rows };\n  });\n\nconst extractLabels = (\n  columnIds: PTableColumnId[],\n  table: CalculateTableDataResponse,\n): { rows: string[] }[] =>\n  columnIds.map((columnId) => {\n    const column = table.find(({ spec }) => {\n      if (columnId.type === 'axis' && spec.type === 'axis') {\n        return isJsonEqual(columnId.id, spec.id);\n      }\n      if (columnId.type === 'column' && spec.type === 'column') {\n        return columnId.id === spec.id;\n      }\n    });\n    if (!column) {\n      throw new Error(`Couldn't find label column (ID: \\`${columnId}\\`).`);\n    }\n    const rows = column.data.data\n      .keys()\n      .take(SEQUENCE_LIMIT)\n      .map((row) =>\n        pTableValue(column.data, row, { absent: '', na: '' })?.toString()\n        ?? '',\n      )\n      .toArray();\n    return { rows };\n  });\n\nconst extractMarkups = (\n  columnIds: PObjectId[],\n  table: CalculateTableDataResponse,\n): { labels: Record<string, string>; rows: Markup[] }[] =>\n  columnIds.map((columnId) => {\n    const column = table.find(({ spec }) => spec.id === columnId);\n    if (!column) {\n      throw new Error(`Couldn't find markup column (ID: \\`${columnId}\\`).`);\n    }\n    const labels = readAnnotationJson(\n      column.spec.spec,\n      Annotation.Sequence.Annotation.Mapping,\n    ) ?? {};\n    const rows = column.data.data\n      .keys()\n      .take(SEQUENCE_LIMIT)\n      .map((row) =>\n        parseMarkup(\n          pTableValue(column.data, row, { absent: '', na: '' })?.toString()\n          ?? '',\n        ),\n      )\n      .toArray();\n    return { labels, rows };\n  });\n\nconst alignSequences = (() => {\n  const cache = new Map<string, string[]>();\n  return async (\n    sequences: string[],\n    alignmentParams: PlMultiSequenceAlignmentSettings['alignmentParams'],\n    abortSignal: AbortSignal,\n  ): Promise<string[]> => {\n    const hash = await objectHash([sequences, alignmentParams]);\n    let result = cache.get(hash);\n    if (result) return result;\n    result = await runInWorker<\n      MultiSequenceAlignmentWorker.RequestMessage,\n      MultiSequenceAlignmentWorker.ResponseMessage\n    >(\n      new Worker(\n        new URL('./multi-sequence-alignment.worker.ts', import.meta.url),\n        { type: 'module' },\n      ),\n      { sequences, params: alignmentParams },\n      abortSignal,\n    );\n    cache.set(hash, result);\n    return result;\n  };\n})();\n\nfunction generateHighlightImage(\n  { colorScheme, sequences, residueCounts, markup }: {\n    colorScheme: PlMultiSequenceAlignmentColorSchemeOption;\n    sequences: string[];\n    residueCounts: ResidueCounts;\n    markup: { labels: Record<string, string>; rows: Markup[] } | undefined;\n  },\n): { blob: Blob; legend: HighlightLegend } | undefined {\n  if (colorScheme.type === 'chemical-properties') {\n    return highlightByChemicalProperties({ sequences, residueCounts });\n  }\n  if (colorScheme.type === 'markup') {\n    if (!markup) {\n      throw new Error('Missing markup data.');\n    }\n    return highlightByMarkup({\n      markupRows: sequences.map((sequence, row) => {\n        const markupRow = markup.rows.at(row);\n        if (!markupRow) throw new Error(`Missing markup for row ${row}.`);\n        return markupAlignedSequence(sequence, markupRow);\n      }),\n      columnCount: sequences.at(0)?.length ?? 0,\n      labels: markup.labels,\n    });\n  }\n}\n\nconst blobToBase64 = (blob: Blob): Promise<string> =>\n  new Promise<string>((resolve, reject) => {\n    const reader = new FileReader();\n    reader.addEventListener('load', () => resolve(reader.result as string));\n    reader.addEventListener('error', () => reject(reader.error));\n    reader.readAsDataURL(blob);\n  });\n\nconst buildPhylogeneticTree = (() => {\n  const cache = new Map<string, PhylogeneticTreeWorker.TreeNodeData[]>();\n  return async (data: { rows: string[] }[], abortSignal: AbortSignal) => {\n    const concatenatedSequences = data.at(0)?.rows\n      .keys()\n      .map((row) => data.map((column) => column.rows.at(row) ?? '').join(''))\n      .toArray() ?? [];\n    const hash = await objectHash(concatenatedSequences);\n    let result = cache.get(hash);\n    if (result) return result;\n    result = await runInWorker<\n      PhylogeneticTreeWorker.RequestMessage,\n      PhylogeneticTreeWorker.ResponseMessage\n    >(\n      new Worker(\n        new URL('./phylogenetic-tree.worker.ts', import.meta.url),\n        { type: 'module' },\n      ),\n      concatenatedSequences,\n      abortSignal,\n    );\n    cache.set(hash, result);\n    return result;\n  };\n})();\n\nconst runInWorker = <RequestMessage, ResponseMessage>(\n  worker: Worker,\n  message: RequestMessage,\n  abortSignal: AbortSignal,\n) =>\n  new Promise<ResponseMessage>((resolve, reject) => {\n    worker.addEventListener('message', ({ data }) => {\n      resolve(data);\n      worker.terminate();\n    });\n    worker.addEventListener('error', ({ error, message }) => {\n      reject(error ?? message);\n      worker.terminate();\n    });\n    abortSignal.addEventListener('abort', () => {\n      reject(abortSignal.reason);\n      worker.terminate();\n    });\n    worker.postMessage(message);\n  });\n\nfunction refreshOnDeepChange<T, P>(\n  cb: (params: P, abortSignal: AbortSignal) => Promise<T>,\n) {\n  const data = ref<T>();\n  const isLoading = ref(true);\n  const error = ref<Error>();\n  let requestId: symbol;\n  return (paramsGetter: () => P) => {\n    watch(paramsGetter, async (params, prevParams) => {\n      if (isJsonEqual(params, prevParams)) return;\n      const abortController = new AbortController();\n      const currentRequestId = requestId = Symbol();\n      onWatcherCleanup(() => {\n        abortController.abort();\n      });\n      try {\n        error.value = undefined;\n        isLoading.value = true;\n        const result = await cb(params, abortController.signal);\n        if (currentRequestId === requestId) {\n          data.value = result;\n        }\n      } catch (err) {\n        console.error(err);\n        if (currentRequestId === requestId) {\n          error.value = ensureError(err);\n        }\n      } finally {\n        if (currentRequestId === requestId) {\n          isLoading.value = false;\n        }\n      }\n    }, { immediate: true });\n    return { data, isLoading, error };\n  };\n}\n\ntype MultipleAlignmentData = {\n  sequences: {\n    name: string;\n    rows: string[];\n    residueCounts: ResidueCounts;\n    highlightImageUrl?: string;\n  }[];\n  labels: {\n    rows: string[];\n  }[];\n  highlightLegend?: HighlightLegend;\n  phylogeneticTree?: PhylogeneticTreeWorker.TreeNodeData[];\n  exceedsLimit: boolean;\n};\n\ntype OptionsWithDefaults<T> = {\n  options: ListOptionNormalized<T>[];\n  defaults: T[];\n};\n"],"names":["getPFrameDriver","getRawPlatformaInstance","SEQUENCE_LIMIT","useSequenceColumnsOptions","refreshOnDeepChange","getSequenceColumnsOptions","useLabelColumnsOptions","getLabelColumnsOptions","useMarkupColumnsOptions","getMarkupColumnsOptions","useMultipleAlignmentData","getMultipleAlignmentData","pFrame","sequenceColumnPredicate","options","column","spec","columnId","readAnnotation","Annotation","defaults","value","sequenceColumnIds","pFrameDriver","columns","sequenceColumnsAxes","id","canonicalizeJson","getAxisId","optionMap","axisIdJson","axisSpec","axisId","parseJson","labelColumn","isLabelColumn","matchAxisId","compatibleColumns","columnIdJson","label","columnPairs","sequenceColumn","readAnnotationJson","isJsonEqual","key","_a","markupColumn","domainDiff","domainDiffJson","labelColumnIds","selection","colorScheme","alignmentParams","shouldBuildPhylogeneticTree","abortSignal","table","getTableData","rowCount","exceedsLimit","rawSequences","extractSequences","labels","extractLabels","markups","extractMarkups","highlightLegend","alignedSequences","name","rows","alignSequences","phylogeneticTree","buildPhylogeneticTree","rowOrder","sequencesColumn","i","labelsColumn","markupsColumn","index","residueCounts","getResidueCounts","image","generateHighlightImage","blobToBase64","linkerColumns","isLinkerColumn","filterColumn","createRowSelectionColumn","primaryEntry","secondaryEntry","sorting","request","columnIds","row","pTableValue","parseMarkup","cache","sequences","hash","objectHash","result","runInWorker","markup","highlightByChemicalProperties","highlightByMarkup","sequence","markupRow","markupAlignedSequence","blob","resolve","reject","reader","data","concatenatedSequences","worker","message","error","cb","ref","isLoading","requestId","paramsGetter","watch","params","prevParams","abortController","currentRequestId","onWatcherCleanup","err","ensureError"],"mappings":";;;;;;;;AA2CA,MAAMA,IAAkB,MAAMC,EAAA,EAA0B,cAE3CC,IAAiB,KAEjBC,KAA4BC;AAAA,EACvCC;AACF,GAEaC,KAAyBF;AAAA,EACpCG;AACF,GAEaC,KAA0BJ;AAAA,EACrCK;AACF,GAEaC,KAA2BN;AAAA,EACtCO;AACF;AAEA,eAAeN,EAA0B,EAAE,QAAAO,GAAQ,yBAAAC,KAGK;AACtD,MAAI,CAACD,EAAQ;AAKb,QAAME,KAFU,MADKd,EAAA,EACc,YAAYY,CAAM,GAE7B,OAAA,EACrB,OAAO,CAACG,MAAWF,EAAwBE,CAAM,CAAC,EAClD,IAAI,CAAC,EAAE,MAAAC,GAAM,UAAAC,SAAgB;AAAA,IAC5B,OAAOC,EAAeF,GAAMG,EAAW,KAAK,KAAK;AAAA,IACjD,OAAOF;AAAA,EAAA,EACP,EACD,QAAA,GAEGG,IAAWN,EAAQ,IAAI,CAAC,EAAE,OAAAO,EAAA,MAAYA,CAAK;AAEjD,SAAO,EAAE,SAAAP,GAAS,UAAAM,EAAA;AACpB;AAEA,eAAeb,EAAuB,EAAE,QAAAK,GAAQ,mBAAAU,KAGa;AAC3D,MAAI,CAACV,KAAU,CAACU,EAAmB;AAEnC,QAAMC,IAAevB,EAAA,GACfwB,IAAU,MAAMD,EAAa,YAAYX,CAAM,GAE/Ca,IAAsB,IAAI;AAAA,IAC9BH,EAAkB,OAAA,EAAS,QAAQ,CAACI,MAAO;AACzC,YAAMX,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,EAAA,MAAeA,MAAaS,CAAE;AAC7D,UAAI,CAACX;AACH,cAAM,IAAI,MAAM,wCAAwCW,CAAE,MAAM;AAElE,aAAOX,EAAO,KAAK,SAAS,OAAA,EACzB,IAAI,CAACC,MAAS,CAACW,EAAiBC,EAAUZ,CAAI,CAAC,GAAGA,CAAI,CAAC;AAAA,IAC5D,CAAC;AAAA,EAAA,GAGGa,wBAAgB,IAAA;AACtB,aAAW,CAACC,GAAYC,CAAQ,KAAKN,EAAoB,WAAW;AAClE,UAAMO,IAASC,EAAUH,CAAU,GAC7BI,IAAcV,EAAQ;AAAA,MAAK,CAAC,EAAE,MAAAR,EAAA,MAClCmB,EAAcnB,CAAI,KAAKoB,EAAYJ,GAAQJ,EAAUZ,EAAK,SAAS,CAAC,CAAC,CAAC;AAAA,IAAA;AAExE,IAAAa,EAAU;AAAA,MACRK,IACIP,EAAiB,EAAE,MAAM,UAAU,IAAIO,EAAY,SAAA,CAAU,IAC7DP,EAAiB,EAAE,MAAM,QAAQ,IAAIK,GAAQ;AAAA,MACjDd,EAAegB,KAAA,gBAAAA,EAAa,MAAMf,EAAW,KAAK,KAC/CD,EAAea,GAAUZ,EAAW,KAAK,KACzC;AAAA,IAAA;AAAA,EAEP;AAEA,QAAM,EAAE,MAAMkB,EAAA,IAAsB,MAAMd,EAAa,YAAYX,GAAQ;AAAA,IACzE,cAAc,CAAA;AAAA,IACd,gBAAgBa,EAAoB,KAAA,EACjC,IAAI,CAACK,MAAeG,EAAUH,CAAU,CAAC,EACzC,QAAA;AAAA,IACH,oBAAoB;AAAA,EAAA,CACrB;AAED,aAAW,EAAE,UAAAb,GAAU,MAAAD,EAAA,KAAUqB,GAAmB;AAClD,UAAMC,IAAeX,EAAiC;AAAA,MACpD,MAAM;AAAA,MACN,IAAIV;AAAA,IAAA,CACL;AACD,IAAIY,EAAU,IAAIS,CAAY,KAC9BT,EAAU;AAAA,MACRS;AAAA,MACApB,EAAeF,GAAMG,EAAW,KAAK,KAAK;AAAA,IAAA;AAAA,EAE9C;AAEA,QAAML,IAAUe,EAAU,QAAA,EACvB,IAAI,CAAC,CAACR,GAAOkB,CAAK,OAAO,EAAE,OAAAA,GAAO,OAAON,EAAUZ,CAAK,EAAA,EAAI,EAC5D,QAAA,GAEGD,IAAWN,EAAQ,OAAA,EACtB,OAAO,CAAC,EAAE,OAAAO,QAAY;AACrB,QAAIA,EAAM,SAAS,OAAQ,QAAO;AAClC,UAAMN,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,QAAeA,MAAaI,EAAM,EAAE;AACnE,WAAON,KAAUoB,EAAcpB,EAAO,IAAI;AAAA,EAC5C,CAAC,EACA,IAAI,CAAC,EAAE,OAAAM,EAAA,MAAYA,CAAK,EACxB,QAAA;AAEH,SAAO,EAAE,SAAAP,GAAS,UAAAM,EAAA;AACpB;AAEA,eAAeX,EAAwB,EAAE,QAAAG,GAAQ,mBAAAU,KAGY;AAC3D,MAAI,CAACV,KAAU,CAACU,EAAmB;AAGnC,QAAME,IAAU,MADKxB,EAAA,EACc,YAAYY,CAAM,GAY/C4B,IAVkBlB,EAAkB,IAAI,CAACL,MAAa;AAC1D,UAAMF,IAASS,EAAQ,KAAK,CAACT,MAAWA,EAAO,aAAaE,CAAQ;AACpE,QAAI,CAACF;AACH,YAAM,IAAI;AAAA,QACR,wCAAwCO,EAAkB,CAAC,CAAC;AAAA,MAAA;AAGhE,WAAOP;AAAA,EACT,CAAC,EAGE;AAAA,IAAQ,CAAC0B,MACRjB,EACG;AAAA,MAAO,CAACT,MACP2B,EAAmB3B,EAAO,MAAMI,EAAW,SAAS,YAAY,KAC7DwB,EAAYF,EAAe,KAAK,UAAU1B,EAAO,KAAK,QAAQ,KAC9D,OAAO,QAAQ0B,EAAe,KAAK,UAAU,CAAA,CAAE,EAC/C,MAAM,CAAC,CAACG,GAAKvB,CAAK;;AAAM,iBAAAwB,IAAA9B,EAAO,KAAK,WAAZ,gBAAA8B,EAAqBD,QAASvB;AAAA,OAAK;AAAA,IAAA,EAE/D,IAAI,CAACyB,OAAkB,EAAE,cAAAA,GAAc,gBAAAL,IAAiB;AAAA,EAAA;AAc/D,SAX4B,IAAI;AAAA,IAC9BD;AAAA,IACA,CAAC,EAAE,cAAAM,GAAc,gBAAAL,QAAqB;AACpC,YAAMM,IAAa,OAAO;AAAA,QACxB,OAAO,QAAQD,EAAa,KAAK,UAAU,CAAA,CAAE,EAC1C,OAAO,CAAC,CAACF,CAAG,MAAA;;AAAM,mBAAAC,IAAAJ,EAAe,KAAK,WAApB,gBAAAI,EAA6BD,OAAQ;AAAA,SAAS;AAAA,MAAA;AAErE,aAAOjB,EAAiBoB,CAAU;AAAA,IACpC;AAAA,EAAA,EAGyB,UACxB,IAAI,CAAC,CAACC,GAAgBR,CAAW,OAAO;AAAA,IACvC,OAAO,OAAO,OAAOP,EAAUe,CAAc,CAAC,EAAE,KAAK,IAAI;AAAA,IACzD,OAAOR,EAAY,IAAI,CAAC,EAAE,cAAAM,EAAA,MAAmBA,EAAa,QAAQ;AAAA,EAAA,EAClE,EACD,QAAA;AACL;AAEA,eAAenC,EACb;AAAA,EACE,QAAAC;AAAA,EACA,mBAAAU;AAAA,EACA,gBAAA2B;AAAA,EACA,WAAAC;AAAA,EACA,aAAAC;AAAA,EACA,iBAAAC;AAAA,EACA,6BAAAC;AACF,GASAC,GAC4C;;AAC5C,MAAI,CAAC1C,KAAU,EAACU,KAAA,QAAAA,EAAmB,WAAU,CAAC2B,EAAgB;AAE9D,QAAMM,IAAQ,MAAMC,GAAa;AAAA,IAC/B,QAAA5C;AAAA,IACA,mBAAAU;AAAA,IACA,gBAAA2B;AAAA,IACA,WAAAC;AAAA,IACA,aAAAC;AAAA,EAAA,CACD,GAEKM,MAAWZ,IAAAU,EAAM,GAAG,CAAC,MAAV,gBAAAV,EAAa,KAAK,KAAK,WAAU;AAElD,MAAIY,IAAW,EAAG;AAElB,QAAMC,IAAeD,IAAWvD,GAC1ByD,IAAeC,GAAiBtC,GAAmBiC,CAAK,GACxDM,IAASC,GAAcb,GAAgBM,CAAK,GAC5CQ,IAAUZ,EAAY,SAAS,WACjCa,GAAeb,EAAY,WAAWI,CAAK,IAC3C,QAEEU,IAAmC,CAAA,GAEnCC,IAAmB,MAAM,QAAQ;AAAA,IACrCP,EAAa,IAAI,OAAO,EAAE,MAAAQ,GAAM,MAAAC,SAAY;AAAA,MAC1C,MAAAD;AAAA,MACA,MAAM,MAAME;AAAA,QACVD;AAAA,QACA,KAAK,MAAM,KAAK,UAAUhB,CAAe,CAAC;AAAA,QAC1CE;AAAA,MAAA;AAAA,IACF,EACA;AAAA,EAAA;AAGJ,MAAIgB;AACJ,MAAIjB,GAA6B;AAC/B,IAAAiB,IAAmB,MAAMC;AAAA,MACvBL;AAAA,MACAZ;AAAA,IAAA;AAEF,UAAMkB,IAAWF,EAAiB,OAAA,EAC/B,OAAO,CAAC,EAAE,IAAA5C,EAAA,MAASA,KAAM,CAAC,EAC1B,IAAI,CAAC,EAAE,IAAAA,QAASA,CAAE,EAClB,QAAA;AACH,eAAW+C,KAAmBP;AAC5B,MAAAO,EAAgB,OAAOD,EAAS,IAAI,CAACE,MAAMD,EAAgB,KAAKC,CAAC,CAAC;AAEpE,eAAWC,KAAgBd;AACzB,MAAAc,EAAa,OAAOH,EAAS,IAAI,CAACE,MAAMC,EAAa,KAAKD,CAAC,CAAC;AAE9D,eAAWE,KAAiBb,KAAW;AACrC,MAAAa,EAAc,OAAOJ,EAAS,IAAI,CAACE,MAAME,EAAc,KAAKF,CAAC,CAAC;AAAA,EAElE;AAyBA,SAAO;AAAA,IACL,WAxBgB,MAAM,QAAQ;AAAA,MAC9BR,EAAiB,IAAI,OAAO,EAAE,MAAAC,GAAM,MAAAC,EAAA,GAAQS,MAAU;AACpD,cAAMC,IAAgBC,EAAiBX,CAAI,GACrCY,IAAQC,GAAuB;AAAA,UACnC,aAAA9B;AAAA,UACA,WAAWiB;AAAA,UACX,eAAAU;AAAA,UACA,QAAQf,KAAA,gBAAAA,EAAS,GAAGc;AAAA,QAAK,CAC1B;AACD,eAAIG,KACF,OAAO,OAAOf,GAAiBe,EAAM,MAAM,GAEtC;AAAA,UACL,MAAAb;AAAA,UACA,MAAAC;AAAA,UACA,eAAAU;AAAA,UACA,GAAGE,KAAS;AAAA,YACV,mBAAmB,MAAME,GAAaF,EAAM,IAAI;AAAA,UAAA;AAAA,QAClD;AAAA,MAEJ,CAAC;AAAA,IAAA;AAAA,IAKD,QAAAnB;AAAA,IACA,GAAG,OAAO,KAAKI,CAAe,EAAE,UAAU;AAAA,MACxC,iBAAAA;AAAA,IAAA;AAAA,IAEF,GAAGK,KAAoB;AAAA,MACrB,kBAAAA;AAAA,IAAA;AAAA,IAEF,cAAAZ;AAAA,EAAA;AAEJ;AAEA,eAAeF,GACb,EAAE,QAAA5C,GAAQ,mBAAAU,GAAmB,gBAAA2B,GAAgB,WAAAC,GAAW,aAAAC,KAOnB;AACrC,QAAM5B,IAAevB,EAAA,GACfwB,IAAU,MAAMD,EAAa,YAAYX,CAAM,GAC/CuE,IAAgB3D,EAAQ,OAAO,CAACT,MAAWqE,EAAerE,EAAO,IAAI,CAAC,GAEtEsE,IAAeC,EAAyB,EAAE,WAAApC,GAAW;AAG3D,MAAIqC,IAAqC;AAAA,IACvC,MAAM;AAAA,IACN,SAASjE,EAAkB,IAAI,CAACP,OAAY;AAAA,MAC1C,MAAM;AAAA,MACN,QAAAA;AAAA,IAAA,EACA;AAAA,EAAA;AAIJ,EAAIoE,EAAc,SAAS,MACzBI,IAAe;AAAA,IACb,MAAM;AAAA,IACN,SAASA;AAAA,IACT,WAAWJ,EAAc,IAAI,CAAC,EAAE,UAAAlE,SAAgB;AAAA,MAC9C,MAAM;AAAA,MACN,QAAQA;AAAA,IAAA,EACR;AAAA,EAAA,IAKFoE,MACFE,IAAe;AAAA,IACb,MAAM;AAAA,IACN,SAAS;AAAA,MACPA;AAAA,MACA;AAAA,QACE,MAAM;AAAA,QACN,QAAQF;AAAA,MAAA;AAAA,IACV;AAAA,EACF;AAKJ,QAAMG,IAAyCvC,EAC5C,QAAQ,CAAClC,MACJA,EAAO,SAAS,WAAiB,CAAA,IAC9B,EAAE,MAAM,UAAU,QAAQA,EAAO,GAAA,CACzC;AAGH,MAAIoC,EAAY,SAAS;AACvB,eAAWpC,KAAUoC,EAAY;AAC/B,MAAAqC,EAAe,KAAK,EAAE,MAAM,UAAU,QAAAzE,GAAQ;AAIlD,QAAM0E,IAA2B,MAAM;AAAA,IACrC,IAAI;AAAA,MACFnE,EAAkB,OAAA,EAAS,QAAQ,CAACI,MAAO;AACzC,cAAMX,IAASS,EAAQ,KAAK,CAAC,EAAE,UAAAP,EAAA,MAAeA,MAAaS,CAAE;AAC7D,YAAI,CAACX;AACH,gBAAM,IAAI,MAAM,sCAAsCW,CAAE,GAAG;AAE7D,eAAOX,EAAO,KAAK,SAChB,IAAI,CAACC,MAASW,EAAiBC,EAAUZ,CAAI,CAAC,CAAC;AAAA,MACpD,CAAC;AAAA,IAAA;AAAA,EACH,EAEC,KAAA,EACA,IAAI,CAACU,OAAQ;AAAA,IACZ,QAAQ,EAAE,MAAM,QAAQ,IAAIO,EAAUP,CAAE,EAAA;AAAA,IACxC,WAAW;AAAA,IACX,2BAA2B;AAAA,EAAA,EAC3B,GAEEgE,IAAgD;AAAA,IACpD,KAAK;AAAA,MACH,MAAM;AAAA,MACN,SAASH;AAAA,MACT,WAAWC;AAAA,IAAA;AAAA,IAEb,SAAS,CAAA;AAAA,IACT,SAAAC;AAAA,EAAA;AAGF,SAAOlE,EAAa;AAAA,IAClBX;AAAA,IACA,KAAK,MAAM,KAAK,UAAU8E,CAAO,CAAC;AAAA,IAClC;AAAA,MACE,QAAQ;AAAA;AAAA,MAER,QAAQxF,IAAiB;AAAA,IAAA;AAAA,EAC3B;AAEJ;AAEA,MAAM0D,KAAmB,CACvB+B,GACApC,MAEAoC,EAAU,IAAI,CAAC1E,MAAa;AAC1B,QAAMF,IAASwC,EAAM,KAAK,CAAC,EAAE,MAAAvC,QAAWA,EAAK,OAAOC,CAAQ;AAC5D,MAAI,CAACF;AACH,UAAM,IAAI,MAAM,wCAAwCE,CAAQ,MAAM;AAExE,QAAMkD,IAAOjD,EAAeH,EAAO,KAAK,MAAMI,EAAW,KAAK,KACzD,oBACCiD,IAAOrD,EAAO,KAAK,KACtB,OACA,KAAKb,CAAc,EACnB;AAAA,IAAI,CAAC0F,MAAA;;AACJ,eAAA/C,IAAAgD,EAAY9E,EAAO,MAAM6E,GAAK,EAAE,QAAQ,IAAI,IAAI,IAAI,MAApD,gBAAA/C,EAAuD,eACpD;AAAA;AAAA,EAAA,EAEJ,QAAA;AACH,SAAO,EAAE,MAAAsB,GAAM,MAAAC,EAAA;AACjB,CAAC,GAEGN,KAAgB,CACpB6B,GACApC,MAEAoC,EAAU,IAAI,CAAC1E,MAAa;AAC1B,QAAMF,IAASwC,EAAM,KAAK,CAAC,EAAE,MAAAvC,QAAW;AACtC,QAAIC,EAAS,SAAS,UAAUD,EAAK,SAAS;AAC5C,aAAO2B,EAAY1B,EAAS,IAAID,EAAK,EAAE;AAEzC,QAAIC,EAAS,SAAS,YAAYD,EAAK,SAAS;AAC9C,aAAOC,EAAS,OAAOD,EAAK;AAAA,EAEhC,CAAC;AACD,MAAI,CAACD;AACH,UAAM,IAAI,MAAM,qCAAqCE,CAAQ,MAAM;AAUrE,SAAO,EAAE,MARIF,EAAO,KAAK,KACtB,OACA,KAAKb,CAAc,EACnB;AAAA,IAAI,CAAC0F,MAAA;;AACJ,eAAA/C,IAAAgD,EAAY9E,EAAO,MAAM6E,GAAK,EAAE,QAAQ,IAAI,IAAI,IAAI,MAApD,gBAAA/C,EAAuD,eACpD;AAAA;AAAA,EAAA,EAEJ,QAAA,EACM;AACX,CAAC,GAEGmB,KAAiB,CACrB2B,GACApC,MAEAoC,EAAU,IAAI,CAAC1E,MAAa;AAC1B,QAAMF,IAASwC,EAAM,KAAK,CAAC,EAAE,MAAAvC,QAAWA,EAAK,OAAOC,CAAQ;AAC5D,MAAI,CAACF;AACH,UAAM,IAAI,MAAM,sCAAsCE,CAAQ,MAAM;AAEtE,QAAM4C,IAASnB;AAAA,IACb3B,EAAO,KAAK;AAAA,IACZI,EAAW,SAAS,WAAW;AAAA,EAAA,KAC5B,CAAA,GACCiD,IAAOrD,EAAO,KAAK,KACtB,OACA,KAAKb,CAAc,EACnB;AAAA,IAAI,CAAC0F,MAAA;;AACJ,aAAAE;AAAA,UACEjD,IAAAgD,EAAY9E,EAAO,MAAM6E,GAAK,EAAE,QAAQ,IAAI,IAAI,IAAI,MAApD,gBAAA/C,EAAuD,eACpD;AAAA,MAAA;AAAA;AAAA,EACL,EAED,QAAA;AACH,SAAO,EAAE,QAAAgB,GAAQ,MAAAO,EAAA;AACnB,CAAC,GAEGC,KAAkB,uBAAM;AAC5B,QAAM0B,wBAAY,IAAA;AAClB,SAAO,OACLC,GACA5C,GACAE,MACsB;AACtB,UAAM2C,IAAO,MAAMC,EAAW,CAACF,GAAW5C,CAAe,CAAC;AAC1D,QAAI+C,IAASJ,EAAM,IAAIE,CAAI;AAC3B,WAAIE,MACJA,IAAS,MAAMC;AAAA,MAIb,IAAI;AAAA,QACF,IAAA;AAAA;AAAA,UAAA,KAAA,IAAA,IAAA,4DAAA,YAAA,GAAA,EAAA;AAAA,UAAA,YAAA;AAAA,QAAA;AAAA,QACA,EAAE,MAAM,SAAA;AAAA,MAAS;AAAA,MAEnB,EAAE,WAAAJ,GAAW,QAAQ5C,EAAA;AAAA,MACrBE;AAAA,IAAA,GAEFyC,EAAM,IAAIE,GAAME,CAAM,GACfA;AAAA,EACT;AACF,GAAA;AAEA,SAASlB,GACP,EAAE,aAAA9B,GAAa,WAAA6C,GAAW,eAAAlB,GAAe,QAAAuB,KAMY;;AACrD,MAAIlD,EAAY,SAAS;AACvB,WAAOmD,EAA8B,EAAE,WAAAN,GAAW,eAAAlB,GAAe;AAEnE,MAAI3B,EAAY,SAAS,UAAU;AACjC,QAAI,CAACkD;AACH,YAAM,IAAI,MAAM,sBAAsB;AAExC,WAAOE,EAAkB;AAAA,MACvB,YAAYP,EAAU,IAAI,CAACQ,GAAUZ,MAAQ;AAC3C,cAAMa,IAAYJ,EAAO,KAAK,GAAGT,CAAG;AACpC,YAAI,CAACa,EAAW,OAAM,IAAI,MAAM,0BAA0Bb,CAAG,GAAG;AAChE,eAAOc,EAAsBF,GAAUC,CAAS;AAAA,MAClD,CAAC;AAAA,MACD,eAAa5D,IAAAmD,EAAU,GAAG,CAAC,MAAd,gBAAAnD,EAAiB,WAAU;AAAA,MACxC,QAAQwD,EAAO;AAAA,IAAA,CAChB;AAAA,EACH;AACF;AAEA,MAAMnB,KAAe,CAACyB,MACpB,IAAI,QAAgB,CAACC,GAASC,MAAW;AACvC,QAAMC,IAAS,IAAI,WAAA;AACnB,EAAAA,EAAO,iBAAiB,QAAQ,MAAMF,EAAQE,EAAO,MAAgB,CAAC,GACtEA,EAAO,iBAAiB,SAAS,MAAMD,EAAOC,EAAO,KAAK,CAAC,GAC3DA,EAAO,cAAcH,CAAI;AAC3B,CAAC,GAEGpC,KAAyB,uBAAM;AACnC,QAAMwB,wBAAY,IAAA;AAClB,SAAO,OAAOgB,GAA4BzD,MAA6B;;AACrE,UAAM0D,MAAwBnE,IAAAkE,EAAK,GAAG,CAAC,MAAT,gBAAAlE,EAAY,KACvC,OACA,IAAI,CAAC+C,MAAQmB,EAAK,IAAI,CAAChG,MAAWA,EAAO,KAAK,GAAG6E,CAAG,KAAK,EAAE,EAAE,KAAK,EAAE,GACpE,cAAa,CAAA,GACVK,IAAO,MAAMC,EAAWc,CAAqB;AACnD,QAAIb,IAASJ,EAAM,IAAIE,CAAI;AAC3B,WAAIE,MACJA,IAAS,MAAMC;AAAA,MAIb,IAAI;AAAA,QACF,IAAA;AAAA;AAAA,UAAA,KAAA,IAAA,IAAA,qDAAA,YAAA,GAAA,EAAA;AAAA,UAAA,YAAA;AAAA,QAAA;AAAA,QACA,EAAE,MAAM,SAAA;AAAA,MAAS;AAAA,MAEnBY;AAAA,MACA1D;AAAA,IAAA,GAEFyC,EAAM,IAAIE,GAAME,CAAM,GACfA;AAAA,EACT;AACF,GAAA,GAEMC,IAAc,CAClBa,GACAC,GACA5D,MAEA,IAAI,QAAyB,CAACsD,GAASC,MAAW;AAChD,EAAAI,EAAO,iBAAiB,WAAW,CAAC,EAAE,MAAAF,QAAW;AAC/C,IAAAH,EAAQG,CAAI,GACZE,EAAO,UAAA;AAAA,EACT,CAAC,GACDA,EAAO,iBAAiB,SAAS,CAAC,EAAE,OAAAE,GAAO,SAAAD,QAAc;AACvD,IAAAL,EAAOM,KAASD,CAAO,GACvBD,EAAO,UAAA;AAAA,EACT,CAAC,GACD3D,EAAY,iBAAiB,SAAS,MAAM;AAC1C,IAAAuD,EAAOvD,EAAY,MAAM,GACzB2D,EAAO,UAAA;AAAA,EACT,CAAC,GACDA,EAAO,YAAYC,CAAO;AAC5B,CAAC;AAEH,SAAS9G,EACPgH,GACA;AACA,QAAML,IAAOM,EAAA,GACPC,IAAYD,EAAI,EAAI,GACpBF,IAAQE,EAAA;AACd,MAAIE;AACJ,SAAO,CAACC,OACNC,EAAMD,GAAc,OAAOE,GAAQC,MAAe;AAChD,QAAIhF,EAAY+E,GAAQC,CAAU,EAAG;AACrC,UAAMC,IAAkB,IAAI,gBAAA,GACtBC,IAAmBN,IAAY,OAAA;AACrC,IAAAO,EAAiB,MAAM;AACrB,MAAAF,EAAgB,MAAA;AAAA,IAClB,CAAC;AACD,QAAI;AACF,MAAAT,EAAM,QAAQ,QACdG,EAAU,QAAQ;AAClB,YAAMnB,IAAS,MAAMiB,EAAGM,GAAQE,EAAgB,MAAM;AACtD,MAAIC,MAAqBN,MACvBR,EAAK,QAAQZ;AAAA,IAEjB,SAAS4B,GAAK;AACZ,cAAQ,MAAMA,CAAG,GACbF,MAAqBN,MACvBJ,EAAM,QAAQa,EAAYD,CAAG;AAAA,IAEjC,UAAA;AACE,MAAIF,MAAqBN,MACvBD,EAAU,QAAQ;AAAA,IAEtB;AAAA,EACF,GAAG,EAAE,WAAW,IAAM,GACf,EAAE,MAAAP,GAAM,WAAAO,GAAW,OAAAH,EAAA;AAE9B;"}

package/dist/components/PlMultiSequenceAlignment/markup.js

@@ -32,13 +32,15 @@ function C({ markupRows: o, columnCount: l, labels: r }) {
       i || n.set(s, i = []), i.push({ row: e, start: u, length: c });
     }
   const t = Object.fromEntries(
-    Object.entries(r).filter(([e]) => n.has(e)).map(([e, F], s) => [
-      e,
-      {
-        label: F,
-        color: g[s % g.length]
-      }
-    ])
+    Object.entries(r).map(
+      ([e, F], s) => [
+        e,
+        {
+          label: F,
+          color: g[s % g.length]
+        }
+      ]
+    ).filter(([e]) => n.has(e))
   );
   return { blob: new Blob(
     function* () {

package/dist/components/PlMultiSequenceAlignment/markup.js.map

@@ -1 +1 @@
-{"version":3,"file":"markup.js","sources":["../../../src/components/PlMultiSequenceAlignment/markup.ts"],"sourcesContent":["import type { HighlightLegend } from './types';\n\nexport type Markup = { id: string; start: number; length: number }[];\n\nexport function parseMarkup(row: string): Markup {\n  return Array.from(row.matchAll(\n    /(?<id>[^:]*):(?<start>[0-9A-Za-z]*)(?:\\+(?<length>[0-9A-Za-z]*))?\\|?/g,\n  )).map((match) => {\n    const matchGroups = match.groups as {\n      id: string;\n      start: string;\n      length: string | undefined;\n    };\n    const start = Number.parseInt(matchGroups.start, 36);\n    const length = matchGroups.length\n      ? Number.parseInt(matchGroups.length, 36)\n      : 0;\n    return {\n      id: matchGroups.id,\n      start,\n      length,\n    };\n  });\n}\n\nexport function markupAlignedSequence(\n  alignedSequence: string,\n  markup: Markup,\n): Markup {\n  const indexMap = alignedSequence.split('').reduce<number[]>(\n    (acc, char, index) => {\n      if (char !== '-') acc.push(index);\n      return acc;\n    },\n    [],\n  );\n  const adjusted = markup.map((segment) => {\n    const start = indexMap[segment.start];\n    const end = indexMap[segment.start + segment.length - 1] + 1;\n    return {\n      id: segment.id,\n      start: start,\n      length: end - start,\n    };\n  });\n  return adjusted;\n}\n\nexport function highlightByMarkup(\n  { markupRows, columnCount, labels }: {\n    markupRows: Markup[];\n    columnCount: number;\n    labels: Record<string, string>;\n  },\n): { blob: Blob; legend: HighlightLegend } {\n  const linesById: Map<string, {\n    row: number;\n    start: number;\n    length: number;\n  }[]> = new Map();\n  for (const [row, markup] of markupRows.entries()) {\n    for (const { id, start, length } of markup) {\n      let bucket = linesById.get(id);\n      if (!bucket) linesById.set(id, bucket = []);\n      bucket.push({ row, start, length });\n    }\n  }\n  const legend: HighlightLegend = Object.fromEntries(\n    Object.entries(labels)\n      .filter(([id]) => linesById.has(id))\n      .map(([id, label], index) => [\n        id,\n        {\n          label,\n          color: markupColors[index % markupColors.length],\n        },\n      ]),\n  );\n  const blob = new Blob(\n    (function*() {\n      const viewBox = `0 0 ${columnCount} ${markupRows.length * 2}`;\n      yield `<svg xmlns=\"http://www.w3.org/2000/svg\" viewBox=\"${viewBox}\" stroke-width=\"2\" preserveAspectRatio=\"none\">`;\n      for (const [id, lines] of linesById) {\n        const { color } = legend[id];\n        yield `<path stroke=\"${color}\" d=\"`;\n        let x = 0, y = 0;\n        for (const { row, start, length } of lines) {\n          yield `m${start - x},${row * 2 + 1 - y}h${length}`;\n          x = start + length;\n          y = row * 2 + 1;\n        }\n        yield '\"/>';\n      }\n      yield '</svg>';\n    })().toArray(),\n    { type: 'image/svg+xml' },\n  );\n  return { blob, legend };\n}\n\nconst markupColors = [\n  '#E5F2FF',\n  '#FFE8E8',\n  '#F0EBFF',\n  '#FFFFE3',\n  '#E5F7E5',\n  '#FEEAFE',\n  '#FDEED6',\n  '#E8FDFE',\n  '#CCDFF2',\n  '#F2CCCD',\n  '#D5CCF2',\n  '#F2F2CC',\n  '#CCF2CC',\n  '#F2CCF2',\n  '#EFDDBF',\n  '#DEEEEF',\n];\n\nif (import.meta.vitest) {\n  const { test, expect } = import.meta.vitest;\n  test('annotateAlignedRow', () => {\n    const alignedSequence\n      = 'EVRLVESGGALVQPGGSLRLSCVAASGFTFINNWVTWVRQAPGKGLEWVANIKEDGSQKYYVDSVKGRFTISRDNAEKSVYLQMSSLRVDDTAVYYCAR------------GRAV----D---QWGQGTLVTVSS';\n    //   0         10        20        30        40        50        60        70        80        90        100       110       120       130\n    //   EVRLVESGGALVQPGGSLRLSCVAASGFTFINNWVTWVRQAPGKGLEWVANIKEDGSQKYYVDSVKGRFTISRDNAEKSVYLQMSSLRVDDTAVYYCARGRAVDQWGQGTLVTVSS\n    const markup = [\n      { id: '1', start: 0, length: 99 },\n      { id: '2', start: 99, length: 3 },\n      { id: '3', start: 102, length: 14 },\n    ];\n    const alignedMarkup = markupAlignedSequence(alignedSequence, markup);\n    expect(alignedMarkup).toEqual([\n      { id: '1', start: 0, length: 99 },\n      { id: '2', start: 111, length: 3 },\n      { id: '3', start: 114, length: 21 },\n    ]);\n  });\n}\n"],"names":["parseMarkup","row","match","matchGroups","start","length","markupAlignedSequence","alignedSequence","markup","indexMap","acc","char","index","segment","end","highlightByMarkup","markupRows","columnCount","labels","linesById","id","bucket","legend","label","markupColors","lines","color","x","y"],"mappings":"AAIO,SAASA,EAAYC,GAAqB;AAC/C,SAAO,MAAM,KAAKA,EAAI;AAAA,IACpB;AAAA,EAAA,CACD,EAAE,IAAI,CAACC,MAAU;AAChB,UAAMC,IAAcD,EAAM,QAKpBE,IAAQ,OAAO,SAASD,EAAY,OAAO,EAAE,GAC7CE,IAASF,EAAY,SACvB,OAAO,SAASA,EAAY,QAAQ,EAAE,IACtC;AACJ,WAAO;AAAA,MACL,IAAIA,EAAY;AAAA,MAChB,OAAAC;AAAA,MACA,QAAAC;AAAA,IAAA;AAAA,EAEJ,CAAC;AACH;AAEO,SAASC,EACdC,GACAC,GACQ;AACR,QAAMC,IAAWF,EAAgB,MAAM,EAAE,EAAE;AAAA,IACzC,CAACG,GAAKC,GAAMC,OACND,MAAS,OAAKD,EAAI,KAAKE,CAAK,GACzBF;AAAA,IAET,CAAA;AAAA,EAAC;AAWH,SATiBF,EAAO,IAAI,CAACK,MAAY;AACvC,UAAMT,IAAQK,EAASI,EAAQ,KAAK,GAC9BC,IAAML,EAASI,EAAQ,QAAQA,EAAQ,SAAS,CAAC,IAAI;AAC3D,WAAO;AAAA,MACL,IAAIA,EAAQ;AAAA,MACZ,OAAAT;AAAA,MACA,QAAQU,IAAMV;AAAA,IAAA;AAAA,EAElB,CAAC;AAEH;AAEO,SAASW,EACd,EAAE,YAAAC,GAAY,aAAAC,GAAa,QAAAC,KAKc;AACzC,QAAMC,wBAIK,IAAA;AACX,aAAW,CAAClB,GAAKO,CAAM,KAAKQ,EAAW;AACrC,eAAW,EAAE,IAAAI,GAAI,OAAAhB,GAAO,QAAAC,EAAA,KAAYG,GAAQ;AAC1C,UAAIa,IAASF,EAAU,IAAIC,CAAE;AAC7B,MAAKC,KAAQF,EAAU,IAAIC,GAAIC,IAAS,EAAE,GAC1CA,EAAO,KAAK,EAAE,KAAApB,GAAK,OAAAG,GAAO,QAAAC,GAAQ;AAAA,IACpC;AAEF,QAAMiB,IAA0B,OAAO;AAAA,IACrC,OAAO,QAAQJ,CAAM,EAClB,OAAO,CAAC,CAACE,CAAE,MAAMD,EAAU,IAAIC,CAAE,CAAC,EAClC,IAAI,CAAC,CAACA,GAAIG,CAAK,GAAGX,MAAU;AAAA,MAC3BQ;AAAA,MACA;AAAA,QACE,OAAAG;AAAA,QACA,OAAOC,EAAaZ,IAAQY,EAAa,MAAM;AAAA,MAAA;AAAA,IACjD,CACD;AAAA,EAAA;AAqBL,SAAO,EAAE,MAnBI,IAAI;AAAA,IACd,aAAY;AAEX,YAAM,oDADU,OAAOP,CAAW,IAAID,EAAW,SAAS,CAAC,EACM;AACjE,iBAAW,CAACI,GAAIK,CAAK,KAAKN,GAAW;AACnC,cAAM,EAAE,OAAAO,EAAA,IAAUJ,EAAOF,CAAE;AAC3B,cAAM,iBAAiBM,CAAK;AAC5B,YAAIC,IAAI,GAAGC,IAAI;AACf,mBAAW,EAAE,KAAA3B,GAAK,OAAAG,GAAO,QAAAC,EAAA,KAAYoB;AACnC,gBAAM,IAAIrB,IAAQuB,CAAC,IAAI1B,IAAM,IAAI,IAAI2B,CAAC,IAAIvB,CAAM,IAChDsB,IAAIvB,IAAQC,GACZuB,IAAI3B,IAAM,IAAI;AAEhB,cAAM;AAAA,MACR;AACA,YAAM;AAAA,IACR,EAAA,EAAK,QAAA;AAAA,IACL,EAAE,MAAM,gBAAA;AAAA,EAAgB,GAEX,QAAAqB,EAAA;AACjB;AAEA,MAAME,IAAe;AAAA,EACnB;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AACF;"}
+{"version":3,"file":"markup.js","sources":["../../../src/components/PlMultiSequenceAlignment/markup.ts"],"sourcesContent":["import type { HighlightLegend } from './types';\n\nexport type Markup = { id: string; start: number; length: number }[];\n\nexport function parseMarkup(row: string): Markup {\n  return Array.from(row.matchAll(\n    /(?<id>[^:]*):(?<start>[0-9A-Za-z]*)(?:\\+(?<length>[0-9A-Za-z]*))?\\|?/g,\n  )).map((match) => {\n    const matchGroups = match.groups as {\n      id: string;\n      start: string;\n      length: string | undefined;\n    };\n    const start = Number.parseInt(matchGroups.start, 36);\n    const length = matchGroups.length\n      ? Number.parseInt(matchGroups.length, 36)\n      : 0;\n    return {\n      id: matchGroups.id,\n      start,\n      length,\n    };\n  });\n}\n\nexport function markupAlignedSequence(\n  alignedSequence: string,\n  markup: Markup,\n): Markup {\n  const indexMap = alignedSequence.split('').reduce<number[]>(\n    (acc, char, index) => {\n      if (char !== '-') acc.push(index);\n      return acc;\n    },\n    [],\n  );\n  const adjusted = markup.map((segment) => {\n    const start = indexMap[segment.start];\n    const end = indexMap[segment.start + segment.length - 1] + 1;\n    return {\n      id: segment.id,\n      start: start,\n      length: end - start,\n    };\n  });\n  return adjusted;\n}\n\nexport function highlightByMarkup(\n  { markupRows, columnCount, labels }: {\n    markupRows: Markup[];\n    columnCount: number;\n    labels: Record<string, string>;\n  },\n): { blob: Blob; legend: HighlightLegend } {\n  const linesById: Map<string, {\n    row: number;\n    start: number;\n    length: number;\n  }[]> = new Map();\n  for (const [row, markup] of markupRows.entries()) {\n    for (const { id, start, length } of markup) {\n      let bucket = linesById.get(id);\n      if (!bucket) linesById.set(id, bucket = []);\n      bucket.push({ row, start, length });\n    }\n  }\n  const legend: HighlightLegend = Object.fromEntries(\n    Object.entries(labels)\n      .map(([id, label], index) =>\n        [\n          id,\n          {\n            label,\n            color: markupColors[index % markupColors.length],\n          },\n        ] as const,\n      )\n      .filter(([id]) => linesById.has(id)),\n  );\n  const blob = new Blob(\n    (function*() {\n      const viewBox = `0 0 ${columnCount} ${markupRows.length * 2}`;\n      yield `<svg xmlns=\"http://www.w3.org/2000/svg\" viewBox=\"${viewBox}\" stroke-width=\"2\" preserveAspectRatio=\"none\">`;\n      for (const [id, lines] of linesById) {\n        const { color } = legend[id];\n        yield `<path stroke=\"${color}\" d=\"`;\n        let x = 0, y = 0;\n        for (const { row, start, length } of lines) {\n          yield `m${start - x},${row * 2 + 1 - y}h${length}`;\n          x = start + length;\n          y = row * 2 + 1;\n        }\n        yield '\"/>';\n      }\n      yield '</svg>';\n    })().toArray(),\n    { type: 'image/svg+xml' },\n  );\n  return { blob, legend };\n}\n\nconst markupColors = [\n  '#E5F2FF',\n  '#FFE8E8',\n  '#F0EBFF',\n  '#FFFFE3',\n  '#E5F7E5',\n  '#FEEAFE',\n  '#FDEED6',\n  '#E8FDFE',\n  '#CCDFF2',\n  '#F2CCCD',\n  '#D5CCF2',\n  '#F2F2CC',\n  '#CCF2CC',\n  '#F2CCF2',\n  '#EFDDBF',\n  '#DEEEEF',\n];\n\nif (import.meta.vitest) {\n  const { test, expect } = import.meta.vitest;\n  test('annotateAlignedRow', () => {\n    const alignedSequence\n      = 'EVRLVESGGALVQPGGSLRLSCVAASGFTFINNWVTWVRQAPGKGLEWVANIKEDGSQKYYVDSVKGRFTISRDNAEKSVYLQMSSLRVDDTAVYYCAR------------GRAV----D---QWGQGTLVTVSS';\n    //   0         10        20        30        40        50        60        70        80        90        100       110       120       130\n    //   EVRLVESGGALVQPGGSLRLSCVAASGFTFINNWVTWVRQAPGKGLEWVANIKEDGSQKYYVDSVKGRFTISRDNAEKSVYLQMSSLRVDDTAVYYCARGRAVDQWGQGTLVTVSS\n    const markup = [\n      { id: '1', start: 0, length: 99 },\n      { id: '2', start: 99, length: 3 },\n      { id: '3', start: 102, length: 14 },\n    ];\n    const alignedMarkup = markupAlignedSequence(alignedSequence, markup);\n    expect(alignedMarkup).toEqual([\n      { id: '1', start: 0, length: 99 },\n      { id: '2', start: 111, length: 3 },\n      { id: '3', start: 114, length: 21 },\n    ]);\n  });\n}\n"],"names":["parseMarkup","row","match","matchGroups","start","length","markupAlignedSequence","alignedSequence","markup","indexMap","acc","char","index","segment","end","highlightByMarkup","markupRows","columnCount","labels","linesById","id","bucket","legend","label","markupColors","lines","color","x","y"],"mappings":"AAIO,SAASA,EAAYC,GAAqB;AAC/C,SAAO,MAAM,KAAKA,EAAI;AAAA,IACpB;AAAA,EAAA,CACD,EAAE,IAAI,CAACC,MAAU;AAChB,UAAMC,IAAcD,EAAM,QAKpBE,IAAQ,OAAO,SAASD,EAAY,OAAO,EAAE,GAC7CE,IAASF,EAAY,SACvB,OAAO,SAASA,EAAY,QAAQ,EAAE,IACtC;AACJ,WAAO;AAAA,MACL,IAAIA,EAAY;AAAA,MAChB,OAAAC;AAAA,MACA,QAAAC;AAAA,IAAA;AAAA,EAEJ,CAAC;AACH;AAEO,SAASC,EACdC,GACAC,GACQ;AACR,QAAMC,IAAWF,EAAgB,MAAM,EAAE,EAAE;AAAA,IACzC,CAACG,GAAKC,GAAMC,OACND,MAAS,OAAKD,EAAI,KAAKE,CAAK,GACzBF;AAAA,IAET,CAAA;AAAA,EAAC;AAWH,SATiBF,EAAO,IAAI,CAACK,MAAY;AACvC,UAAMT,IAAQK,EAASI,EAAQ,KAAK,GAC9BC,IAAML,EAASI,EAAQ,QAAQA,EAAQ,SAAS,CAAC,IAAI;AAC3D,WAAO;AAAA,MACL,IAAIA,EAAQ;AAAA,MACZ,OAAAT;AAAA,MACA,QAAQU,IAAMV;AAAA,IAAA;AAAA,EAElB,CAAC;AAEH;AAEO,SAASW,EACd,EAAE,YAAAC,GAAY,aAAAC,GAAa,QAAAC,KAKc;AACzC,QAAMC,wBAIK,IAAA;AACX,aAAW,CAAClB,GAAKO,CAAM,KAAKQ,EAAW;AACrC,eAAW,EAAE,IAAAI,GAAI,OAAAhB,GAAO,QAAAC,EAAA,KAAYG,GAAQ;AAC1C,UAAIa,IAASF,EAAU,IAAIC,CAAE;AAC7B,MAAKC,KAAQF,EAAU,IAAIC,GAAIC,IAAS,EAAE,GAC1CA,EAAO,KAAK,EAAE,KAAApB,GAAK,OAAAG,GAAO,QAAAC,GAAQ;AAAA,IACpC;AAEF,QAAMiB,IAA0B,OAAO;AAAA,IACrC,OAAO,QAAQJ,CAAM,EAClB;AAAA,MAAI,CAAC,CAACE,GAAIG,CAAK,GAAGX,MACjB;AAAA,QACEQ;AAAA,QACA;AAAA,UACE,OAAAG;AAAA,UACA,OAAOC,EAAaZ,IAAQY,EAAa,MAAM;AAAA,QAAA;AAAA,MACjD;AAAA,IACF,EAED,OAAO,CAAC,CAACJ,CAAE,MAAMD,EAAU,IAAIC,CAAE,CAAC;AAAA,EAAA;AAqBvC,SAAO,EAAE,MAnBI,IAAI;AAAA,IACd,aAAY;AAEX,YAAM,oDADU,OAAOH,CAAW,IAAID,EAAW,SAAS,CAAC,EACM;AACjE,iBAAW,CAACI,GAAIK,CAAK,KAAKN,GAAW;AACnC,cAAM,EAAE,OAAAO,EAAA,IAAUJ,EAAOF,CAAE;AAC3B,cAAM,iBAAiBM,CAAK;AAC5B,YAAIC,IAAI,GAAGC,IAAI;AACf,mBAAW,EAAE,KAAA3B,GAAK,OAAAG,GAAO,QAAAC,EAAA,KAAYoB;AACnC,gBAAM,IAAIrB,IAAQuB,CAAC,IAAI1B,IAAM,IAAI,IAAI2B,CAAC,IAAIvB,CAAM,IAChDsB,IAAIvB,IAAQC,GACZuB,IAAI3B,IAAM,IAAI;AAEhB,cAAM;AAAA,MACR;AACA,YAAM;AAAA,IACR,EAAA,EAAK,QAAA;AAAA,IACL,EAAE,MAAM,gBAAA;AAAA,EAAgB,GAEX,QAAAqB,EAAA;AACjB;AAEA,MAAME,IAAe;AAAA,EACnB;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AAAA,EACA;AACF;"}

package/dist/components/PlMultiSequenceAlignment/migrations.js

@@ -1,22 +1,24 @@
-import { parseJson as s } from "@platforma-sdk/model";
-const e = 1;
-function a(r) {
-  const t = i(r.value);
+import { parseJson as u } from "@platforma-sdk/model";
+const o = 2;
+function l(r) {
+  var t;
+  const n = s(r.value);
   try {
-    if (t < 1) {
-      const n = r.value.labelColumnIds;
-      n && (r.value.labelColumnIds = n.map((o) => s(o)));
+    if (n < 1) {
+      const e = r.value.labelColumnIds;
+      e && (r.value.labelColumnIds = e.map((i) => u(i)));
     }
-  } catch (n) {
-    console.error(n), r.value = {};
+    n < 2 && ((t = r.value.colorScheme) == null ? void 0 : t.type) === "markup" && delete r.value.colorScheme;
+  } catch (e) {
+    console.error(e), r.value = {};
   } finally {
-    r.value.version = e;
+    r.value.version = o;
   }
 }
-function i(r) {
-  return r.version !== void 0 ? r.version : Object.keys(r).length ? 0 : e;
+function s(r) {
+  return r.version !== void 0 ? r.version : Object.keys(r).length ? 0 : o;
 }
 export {
-  a as runMigrations
+  l as runMigrations
 };
 //# sourceMappingURL=migrations.js.map

package/dist/components/PlMultiSequenceAlignment/migrations.js.map

@@ -1 +1 @@
-{"version":3,"file":"migrations.js","sources":["../../../src/components/PlMultiSequenceAlignment/migrations.ts"],"sourcesContent":["import {\n  type CanonicalizedJson,\n  parseJson,\n  type PlMultiSequenceAlignmentModel,\n  type PTableColumnId,\n} from '@platforma-sdk/model';\nimport { type Ref } from 'vue';\n\nconst latestVersion = 1;\n\nexport function runMigrations(model: Ref<PlMultiSequenceAlignmentModel>) {\n  const currentVersion = getCurrentVersion(model.value);\n  try {\n    if (currentVersion < 1) {\n      const oldLabelColumnIds = model.value.labelColumnIds as unknown as\n        | CanonicalizedJson<PTableColumnId>[]\n        | undefined;\n      if (oldLabelColumnIds) {\n        model.value.labelColumnIds = oldLabelColumnIds\n          .map((id) => parseJson(id));\n      }\n    }\n  } catch (error) {\n    console.error(error);\n    model.value = {};\n  } finally {\n    model.value.version = latestVersion;\n  }\n}\n\n/**\n * If a model has a version, return it.\n * If it doesn't, but contains anything at all, that's version 0,\n * which is a pre-versioning version.\n * Otherwise, emtpy model is treated as the latest model.\n */\nfunction getCurrentVersion(model: PlMultiSequenceAlignmentModel) {\n  if (model.version !== undefined) return model.version;\n  if (Object.keys(model).length) return 0;\n  return latestVersion;\n}\n"],"names":["latestVersion","runMigrations","model","currentVersion","getCurrentVersion","oldLabelColumnIds","id","parseJson","error"],"mappings":";AAQA,MAAMA,IAAgB;AAEf,SAASC,EAAcC,GAA2C;AACvE,QAAMC,IAAiBC,EAAkBF,EAAM,KAAK;AACpD,MAAI;AACF,QAAIC,IAAiB,GAAG;AACtB,YAAME,IAAoBH,EAAM,MAAM;AAGtC,MAAIG,MACFH,EAAM,MAAM,iBAAiBG,EAC1B,IAAI,CAACC,MAAOC,EAAUD,CAAE,CAAC;AAAA,IAEhC;AAAA,EACF,SAASE,GAAO;AACd,YAAQ,MAAMA,CAAK,GACnBN,EAAM,QAAQ,CAAA;AAAA,EAChB,UAAA;AACE,IAAAA,EAAM,MAAM,UAAUF;AAAA,EACxB;AACF;AAQA,SAASI,EAAkBF,GAAsC;AAC/D,SAAIA,EAAM,YAAY,SAAkBA,EAAM,UAC1C,OAAO,KAAKA,CAAK,EAAE,SAAe,IAC/BF;AACT;"}
+{"version":3,"file":"migrations.js","sources":["../../../src/components/PlMultiSequenceAlignment/migrations.ts"],"sourcesContent":["import {\n  type CanonicalizedJson,\n  parseJson,\n  type PlMultiSequenceAlignmentModel,\n  type PTableColumnId,\n} from '@platforma-sdk/model';\nimport { type Ref } from 'vue';\n\nconst latestVersion = 2;\n\nexport function runMigrations(model: Ref<PlMultiSequenceAlignmentModel>) {\n  const currentVersion = getCurrentVersion(model.value);\n  try {\n    if (currentVersion < 1) {\n      const oldLabelColumnIds = model.value.labelColumnIds as unknown as\n        | CanonicalizedJson<PTableColumnId>[]\n        | undefined;\n      if (oldLabelColumnIds) {\n        model.value.labelColumnIds = oldLabelColumnIds\n          .map((id) => parseJson(id));\n      }\n    }\n    if (currentVersion < 2) {\n      if (model.value.colorScheme?.type === 'markup') {\n        delete model.value.colorScheme;\n      }\n    }\n  } catch (error) {\n    console.error(error);\n    model.value = {};\n  } finally {\n    model.value.version = latestVersion;\n  }\n}\n\n/**\n * If a model has a version, return it.\n * If it doesn't, but contains anything at all, that's version 0,\n * which is a pre-versioning version.\n * Otherwise, emtpy model is treated as the latest model.\n */\nfunction getCurrentVersion(model: PlMultiSequenceAlignmentModel) {\n  if (model.version !== undefined) return model.version;\n  if (Object.keys(model).length) return 0;\n  return latestVersion;\n}\n"],"names":["latestVersion","runMigrations","model","currentVersion","getCurrentVersion","oldLabelColumnIds","id","parseJson","_a","error"],"mappings":";AAQA,MAAMA,IAAgB;AAEf,SAASC,EAAcC,GAA2C;;AACvE,QAAMC,IAAiBC,EAAkBF,EAAM,KAAK;AACpD,MAAI;AACF,QAAIC,IAAiB,GAAG;AACtB,YAAME,IAAoBH,EAAM,MAAM;AAGtC,MAAIG,MACFH,EAAM,MAAM,iBAAiBG,EAC1B,IAAI,CAACC,MAAOC,EAAUD,CAAE,CAAC;AAAA,IAEhC;AACA,IAAIH,IAAiB,OACfK,IAAAN,EAAM,MAAM,gBAAZ,gBAAAM,EAAyB,UAAS,YACpC,OAAON,EAAM,MAAM;AAAA,EAGzB,SAASO,GAAO;AACd,YAAQ,MAAMA,CAAK,GACnBP,EAAM,QAAQ,CAAA;AAAA,EAChB,UAAA;AACE,IAAAA,EAAM,MAAM,UAAUF;AAAA,EACxB;AACF;AAQA,SAASI,EAAkBF,GAAsC;AAC/D,SAAIA,EAAM,YAAY,SAAkBA,EAAM,UAC1C,OAAO,KAAKA,CAAK,EAAE,SAAe,IAC/BF;AACT;"}

package/dist/components/PlMultiSequenceAlignment/multi-sequence-alignment.worker.d.ts

@@ -0,0 +1,6 @@
+import { PlMultiSequenceAlignmentSettings } from '@platforma-sdk/model';
+export type RequestMessage = {
+    sequences: string[];
+    params: PlMultiSequenceAlignmentSettings['alignmentParams'];
+};
+export type ResponseMessage = string[];

package/dist/components/PlMultiSequenceAlignment/phylogenetic-tree.worker.d.ts

@@ -0,0 +1,7 @@
+export type RequestMessage = string[];
+export type ResponseMessage = TreeNodeData[];
+export interface TreeNodeData {
+    id: number;
+    length?: number;
+    parentId?: number;
+}

package/dist/components/PlMultiSequenceAlignment/settings.js

@@ -1,10 +1,9 @@
-import { defaultAlignmentParams as e } from "./multi-sequence-alignment.js";
-const o = {
+const e = {
   colorScheme: { type: "chemical-properties" },
   widgets: ["seqLogo", "consensus", "legend"],
-  alignmentParams: e
+  alignmentParams: { gpo: 5.5, gpe: 2, tgpe: 1 }
 };
 export {
-  o as defaultSettings
+  e as defaultSettings
 };
 //# sourceMappingURL=settings.js.map

package/dist/components/PlMultiSequenceAlignment/settings.js.map

@@ -1 +1 @@
-{"version":3,"file":"settings.js","sources":["../../../src/components/PlMultiSequenceAlignment/settings.ts"],"sourcesContent":["import type { PlMultiSequenceAlignmentSettings } from '@platforma-sdk/model';\nimport { defaultAlignmentParams } from './multi-sequence-alignment';\n\nexport const defaultSettings: PlMultiSequenceAlignmentSettings = {\n  colorScheme: { type: 'chemical-properties' },\n  widgets: ['seqLogo', 'consensus', 'legend'],\n  alignmentParams: defaultAlignmentParams,\n};\n"],"names":["defaultSettings","defaultAlignmentParams"],"mappings":";AAGO,MAAMA,IAAoD;AAAA,EAC/D,aAAa,EAAE,MAAM,sBAAA;AAAA,EACrB,SAAS,CAAC,WAAW,aAAa,QAAQ;AAAA,EAC1C,iBAAiBC;AACnB;"}
+{"version":3,"file":"settings.js","sources":["../../../src/components/PlMultiSequenceAlignment/settings.ts"],"sourcesContent":["import type { PlMultiSequenceAlignmentSettings } from '@platforma-sdk/model';\n\nexport const defaultSettings: PlMultiSequenceAlignmentSettings = {\n  colorScheme: { type: 'chemical-properties' },\n  widgets: ['seqLogo', 'consensus', 'legend'],\n  alignmentParams: { gpo: 5.5, gpe: 2.0, tgpe: 1.0 },\n};\n"],"names":["defaultSettings"],"mappings":"AAEO,MAAMA,IAAoD;AAAA,EAC/D,aAAa,EAAE,MAAM,sBAAA;AAAA,EACrB,SAAS,CAAC,WAAW,aAAa,QAAQ;AAAA,EAC1C,iBAAiB,EAAE,KAAK,KAAK,KAAK,GAAK,MAAM,EAAA;AAC/C;"}

package/dist/index.js

@@ -1,29 +1,29 @@
 (function(){"use strict";try{if(typeof document<"u"){var r=document.createElement("style");r.appendChild(document.createTextNode(`*{cursor:inherit;box-sizing:border-box;-webkit-font-smoothing:antialiased}.invisible-scrollbar::-webkit-scrollbar{display:none}.block{flex:1;background-color:#fff;max-height:100%;max-width:100%;width:100%;height:100%;position:relative;display:flex;flex-direction:column;--thumb-color: var(--ic-02);overflow-y:auto;overflow-x:auto}.block::-webkit-scrollbar{width:var(--scrollbar-width, 6px);height:5px;background-color:transparent;display:block}.block::-webkit-scrollbar-thumb{background:var(--thumb-color);border-radius:5px}.block::-webkit-scrollbar-thumb:hover{--thumb-color: var(--border-color-focus)}.block__not-found,.block__loader-page{display:flex;flex-direction:column;flex:1;align-items:center;justify-content:center}.block__loader-page .loader-container{display:flex;transform:scale(8)}.block__loader-page .loader-icon{animation:spin 4s linear infinite;background-color:#ccc;margin:auto}.block__layout{padding:0}.block__loader{height:4px;background-color:transparent;position:absolute;z-index:1;top:0;right:0;left:0;overflow:hidden}.block__loader:before{content:"";position:absolute;left:-50%;height:4px;width:33%;background-color:var(--border-color-focus);animation:loader-animation 1.3s linear infinite}.block__progress{--progress-width: 0%;height:4px;background-color:transparent;position:absolute;top:0;right:0;left:0;overflow:hidden}.block__progress:before{content:"";position:absolute;left:0;height:4px;width:var(--progress-width);background-color:var(--border-color-focus);will-change:width;background-image:linear-gradient(90deg,#0000,#fffc,#0000);background-position:0 0;background-size:80px 100%;background-repeat:repeat-y;animation:shine-animation 1.2s linear infinite}@keyframes shine-animation{0%{background-position:-160px 0}to{background-position:calc(100% + 80px) 0}}.block__error{background:var(--txt-error);color:#fff;max-height:50vh;padding:16px 24px;-webkit-user-select:auto;user-select:auto;width:100%;overflow:auto;display:flex;flex-direction:column;--thumb-color: var(--ic-02);overflow-y:auto;overflow-x:auto}.block__error::-webkit-scrollbar{width:var(--scrollbar-width, 6px);height:5px;background-color:transparent;display:block}.block__error::-webkit-scrollbar-thumb{background:var(--thumb-color);border-radius:5px}.block__error::-webkit-scrollbar-thumb:hover{--thumb-color: var(--border-color-focus)}.block__error pre{white-space:pre-wrap;margin:0}.block .scroll-content{height:100%;display:flex;flex-direction:column}.block .scroll-content>div:last-child{flex:1;overflow:auto}@keyframes loader-animation{0%{left:-40%}50%{left:20%;width:38%}to{left:100%;width:50%}}.alert-error{background-color:var(--txt-error);color:#fff;padding:24px}.pl-ag-header-align-center .ag-header-cell-label{justify-content:center}
 .grid-overlay-container{height:calc(100% - 1px);margin-top:1px;width:100%;display:flex;flex-direction:column;align-items:center;justify-content:center;background-color:var(--bg-base-light)}.grid-icon-sad-cat{background-image:url(data:image/png;base64,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);background-repeat:no-repeat}.grid-overlay-container>div{height:300px;width:300px;background-size:contain;background-position:center}.grid-overlay-container>span{color:var(--txt-mask)}
 .pl-ag-cell-status-tag{height:100%;padding:0 12px}
-.pl-ag-chart-stacked-bar-cell{height:100%;display:flex;flex-direction:row;align-items:center}.pl-ag-chart-stacked-bar-cell__not-ready{color:var(--txt-03)!important}
-.pl-ag-chart-histogram-cell{height:100%;display:flex;flex-direction:row;align-items:center}.pl-ag-chart-histogram-cell__not-ready{color:var(--txt-03)!important}`)),document.head.appendChild(r)}}catch(o){console.error("vite-plugin-css-injected-by-js",o)}})();
+.pl-ag-chart-histogram-cell{height:100%;display:flex;flex-direction:row;align-items:center}.pl-ag-chart-histogram-cell__not-ready{color:var(--txt-03)!important}
+.pl-ag-chart-stacked-bar-cell{height:100%;display:flex;flex-direction:row;align-items:center}.pl-ag-chart-stacked-bar-cell__not-ready{color:var(--txt-03)!important}`)),document.head.appendChild(r)}}catch(o){console.error("vite-plugin-css-injected-by-js",o)}})();
 
 import { default as m } from "./components/BlockLayout.vue.js";
-import { default as p, default as s } from "./components/PlAgDataTable/PlAgDataTableV2.vue.js";
+import { default as u, default as p } from "./components/PlAgDataTable/PlAgDataTableV2.vue.js";
 import { default as i } from "./components/PlAgDataTable/PlAgOverlayLoading.vue.js";
 import { default as x } from "./components/PlAgDataTable/PlAgOverlayNoRows.vue.js";
 
 import { default as A } from "./components/ValueOrErrorsComponent.vue.js";
 import { useAgGridOptions as P } from "./AgGridVue/useAgGridOptions.js";
 import { createAgGridColDef as b } from "./AgGridVue/createAgGridColDef.js";
-import { deselectAll as S, getSelectedRowsCount as w, getTotalRowsCount as R, isSelectionEnabled as T, selectAll as D } from "./AgGridVue/selection.js";
+import { deselectAll as w, getSelectedRowsCount as R, getTotalRowsCount as S, isSelectionEnabled as T, selectAll as D } from "./AgGridVue/selection.js";
 import { default as M } from "./components/PlAgColumnHeader/PlAgColumnHeader.vue.js";
 import { default as v } from "./components/PlAgCellFile/PlAgCellFile.vue.js";
 import { default as N } from "./components/PlAgCellProgress/PlAgCellProgress.vue.js";
 import { default as k } from "./components/PlAgCellStatusTag/PlAgCellStatusTag.vue.js";
 
-import { default as B } from "./components/PlAgChartStackedBarCell/PlAgChartStackedBarCell.vue.js";
+import { default as B } from "./components/PlAgChartHistogramCell/PlAgChartHistogramCell.vue.js";
 
-import { default as H } from "./components/PlAgChartHistogramCell/PlAgChartHistogramCell.vue.js";
+import { default as H } from "./components/PlAgChartStackedBarCell/PlAgChartStackedBarCell.vue.js";
 
-import { usePlDataTableSettingsV2 as I } from "./components/PlAgDataTable/types.js";
-import { PlAgDataTableRowNumberColId as Z, autoSizeRowNumberColumn as j, makeRowNumberColDef as z } from "./components/PlAgDataTable/sources/row-number.js";
+import { usePlDataTableSettingsV2 as L } from "./components/PlAgDataTable/types.js";
+import { PlAgDataTableRowNumberColId as j, autoSizeRowNumberColumn as q, makeRowNumberColDef as z } from "./components/PlAgDataTable/sources/row-number.js";
 import { DeferredCircular as J, ensureNodeVisible as K } from "./components/PlAgDataTable/sources/focus-row.js";
 import { defaultMainMenuItems as W } from "./components/PlAgDataTable/sources/menu-items.js";
 import { default as Y } from "./components/PlAgCsvExporter/PlAgCsvExporter.vue.js";
@@ -32,15 +32,14 @@ import { default as re } from "./components/PlAgGridColumnManager/PlAgGridColumn
 import { default as te } from "./components/PlTableFilters/PlTableFiltersV2.vue.js";
 import { default as ae } from "./components/PlMultiSequenceAlignment/PlMultiSequenceAlignment.vue.js";
 import { default as me } from "./components/PlAnnotations/components/PlAnnotationsModal.vue.js";
-import { defineApp as pe, useSdkPlugin as se } from "./defineApp.js";
+import { defineApp as ue, useSdkPlugin as pe } from "./defineApp.js";
 import { createModel as ie } from "./createModel.js";
 import { defineStore as xe } from "./defineStore.js";
 import { AgGridTheme as Ae, activateAgGrid as Ce } from "./aggrid.js";
-import { MultiError as ce, UnresolvedError as be, ensureError as Ee, formatZodError as Se, identity as we, isDefined as Re, isZodError as Te, unwrapValueOrErrors as De, wrapOptionalResult as Ve, wrapValueOrErrors as Me } from "./utils.js";
+import { MultiError as ce, UnresolvedError as be, ensureError as Ee, formatZodError as we, identity as Re, isDefined as Se, isZodError as Te, unwrapValueOrErrors as De, wrapOptionalResult as Ve, wrapValueOrErrors as Me } from "./utils.js";
 import { objectHash as ve } from "./objectHash.js";
 import { computedResult as Ne } from "./computedResult.js";
 import { ReactiveFileContent as ke } from "./composition/fileContent.js";
-import { multiSequenceAlignment as Be } from "./components/PlMultiSequenceAlignment/multi-sequence-alignment.js";
 export * from "@milaboratories/uikit";
 export {
   Ae as AgGridTheme,
@@ -50,49 +49,48 @@ export {
   v as PlAgCellFile,
   N as PlAgCellProgress,
   k as PlAgCellStatusTag,
-  H as PlAgChartHistogramCell,
-  B as PlAgChartStackedBarCell,
+  B as PlAgChartHistogramCell,
+  H as PlAgChartStackedBarCell,
   M as PlAgColumnHeader,
   Y as PlAgCsvExporter,
-  Z as PlAgDataTableRowNumberColId,
-  p as PlAgDataTableV2,
+  j as PlAgDataTableRowNumberColId,
+  u as PlAgDataTableV2,
   re as PlAgGridColumnManager,
   i as PlAgOverlayLoading,
   x as PlAgOverlayNoRows,
   $ as PlAgTextAndButtonCell,
   me as PlAnnotationsModal,
-  s as PlDataTableV2,
+  p as PlDataTableV2,
   ae as PlMultiSequenceAlignment,
   te as PlTableFiltersV2,
   ke as ReactiveFileContent,
   be as UnresolvedError,
   A as ValueOrErrorsComponent,
   Ce as activateAgGrid,
-  j as autoSizeRowNumberColumn,
+  q as autoSizeRowNumberColumn,
   Ne as computedResult,
   b as createAgGridColDef,
   ie as createModel,
   W as defaultMainMenuItems,
-  pe as defineApp,
+  ue as defineApp,
   xe as defineStore,
-  S as deselectAll,
+  w as deselectAll,
   Ee as ensureError,
   K as ensureNodeVisible,
-  Se as formatZodError,
-  w as getSelectedRowsCount,
-  R as getTotalRowsCount,
-  we as identity,
-  Re as isDefined,
+  we as formatZodError,
+  R as getSelectedRowsCount,
+  S as getTotalRowsCount,
+  Re as identity,
+  Se as isDefined,
   T as isSelectionEnabled,
   Te as isZodError,
   z as makeRowNumberColDef,
-  Be as multiSequenceAlignment,
   ve as objectHash,
   D as selectAll,
   De as unwrapValueOrErrors,
   P as useAgGridOptions,
-  I as usePlDataTableSettingsV2,
-  se as useSdkPlugin,
+  L as usePlDataTableSettingsV2,
+  pe as useSdkPlugin,
   Ve as wrapOptionalResult,
   Me as wrapValueOrErrors
 };

package/dist/index.js.map

@@ -1 +1 @@
-{"version":3,"file":"index.js","sources":[],"sourcesContent":[],"names":[],"mappings":";;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;"}
+{"version":3,"file":"index.js","sources":[],"sourcesContent":[],"names":[],"mappings":";;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;"}

package/dist/lib.d.ts

@@ -9,8 +9,8 @@ export * from './components/PlAgColumnHeader';
 export * from './components/PlAgCellFile';
 export * from './components/PlAgCellProgress';
 export * from './components/PlAgCellStatusTag';
-export * from './components/PlAgChartStackedBarCell';
 export * from './components/PlAgChartHistogramCell';
+export * from './components/PlAgChartStackedBarCell';
 export * from './components/PlAgDataTable';
 export * from './components/PlAgCsvExporter';
 export * from './components/PlAgTextAndButtonCell';
@@ -27,6 +27,5 @@ export * from './utils';
 export * from './objectHash';
 export * from './computedResult';
 export * from './composition/fileContent';
-export { multiSequenceAlignment } from './components/PlMultiSequenceAlignment/multi-sequence-alignment';
 export * from '@milaboratories/uikit';
 export type * from '@milaboratories/uikit';

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@platforma-sdk/ui-vue",
-  "version": "1.42.53",
+  "version": "1.43.1",
   "type": "module",
   "main": "dist/index.js",
   "styles": "dist/index.js",
@@ -15,7 +15,7 @@
     "@types/node": "~20.16.15",
     "@types/semver": "^7.7.0",
     "@types/d3-format": "^3.0.4",
-    "@milaboratories/miplots4": "^1.0.123",
+    "@milaboratories/miplots4": "^1.0.145",
     "ag-grid-enterprise": "^34.1.2",
     "ag-grid-vue3": "^34.1.2",
     "canonicalize": "~2.1.0",
@@ -25,9 +25,9 @@
     "@vueuse/integrations": "^13.3.0",
     "d3-format": "^3.1.0",
     "zod": "~3.23.8",
-    "@milaboratories/biowasm-tools": "1.1.2",
-    "@milaboratories/uikit": "2.4.13",
-    "@platforma-sdk/model": "1.42.51"
+    "@milaboratories/biowasm-tools": "2.0.0",
+    "@milaboratories/uikit": "2.4.14",
+    "@platforma-sdk/model": "1.43.0"
   },
   "devDependencies": {
     "happy-dom": "^15.11.7",
@@ -42,8 +42,8 @@
     "yarpm": "^1.2.0",
     "fast-json-patch": "^3.1.1",
     "@faker-js/faker": "^9.2.0",
-    "@milaboratories/eslint-config": "1.0.4",
     "@milaboratories/ts-configs": "1.0.6",
+    "@milaboratories/eslint-config": "1.0.4",
     "@milaboratories/build-configs": "1.0.8",
     "@milaboratories/helpers": "1.8.0",
     "@milaboratories/ts-builder": "1.0.5"