@platforma-open/platforma-open.titeseq-analysis 2.2.0 → 2.3.0

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Files changed (20) hide show
  1. package/block-pack/CHANGELOG.md +3 -0
  2. package/block-pack/block-logo.png +0 -0
  3. package/block-pack/description.md +7 -0
  4. package/block-pack/main.plj.gz +0 -0
  5. package/block-pack/manifest.json +1 -0
  6. package/block-pack/model.json +1 -0
  7. package/block-pack/organization-logo.png +0 -0
  8. package/block-pack/published.json +8 -0
  9. package/block-pack/ui.tgz +0 -0
  10. package/dist/AGENTS.d.ts +9090 -0
  11. package/dist/AGENTS.d.ts.map +1 -0
  12. package/dist/AGENTS.js +0 -0
  13. package/dist/index.d.ts +9101 -0
  14. package/dist/index.d.ts.map +1 -0
  15. package/dist/index.js +14087 -0
  16. package/dist/index.js.map +1 -0
  17. package/dist/rolldown-runtime-DC62tzP2.js +33 -0
  18. package/package.json +27 -11
  19. package/index.d.ts +0 -9
  20. package/index.js +0 -15
package/block-pack/CHANGELOG.md ADDED
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+ ## 1.0.0
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+ Initial release.
package/block-pack/block-logo.png ADDED
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package/block-pack/description.md ADDED
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+ # Overview
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+
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+ Estimates apparent binding affinity (Kd,app) per antibody variant from Tite-Seq data. For each clonotype at each antigen concentration, the block computes a signal (mean-bin from per-bin FACS read counts, or clonotype frequency in no-bin mode), fits a Hill equation to the titration curve, and classifies each clonotype as Good, Partial, or Failed.
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+ The block runs downstream of MiXCR Clonotyping, which supplies per-sample, per-clonotype abundance, and upstream of Antibody/TCR Lead Selection, which consumes Kd,app and affinity class as In Vitro preset inputs. An optional 0 M no-antigen control fixes the Hill baseline and improves fit reliability for weak binders.
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+ Kd,app is apparent affinity, not thermodynamic Kd. Values support within-experiment ranking only and are not comparable across experiments, display formats (scFv vs Fab), or biophysical assays (SPR, BLI). Integer bin labels introduce a systematic compression of the mean-bin scale, following the convention in the Tite-Seq literature (Starr et al. 2020; Adams et al. 2016).
package/block-pack/main.plj.gz ADDED
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package/block-pack/manifest.json ADDED
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+ {"schema":"v2","description":{"id":{"organization":"platforma-open","name":"titeseq-analysis","version":"2.3.0"},"components":{"workflow":{"type":"workflow-v1","main":{"type":"relative","path":"main.plj.gz"}},"model":{"type":"relative","path":"model.json"},"ui":{"type":"relative","path":"ui.tgz"}},"meta":{"title":"Tite-Seq Analysis","description":"Estimates apparent binding affinity (Kd,app) of antibody variants from Tite-Seq reads by fitting a Hill equation to mean-bin signal across antigen concentrations.","longDescription":{"type":"relative","path":"description.md"},"changelog":{"type":"relative","path":"CHANGELOG.md"},"logo":{"type":"relative","path":"block-logo.png"},"url":"https://github.com/platforma-open/platforma-open.titeseq-analysis","support":"mailto:support@milaboratories.com","tags":["airr","downstream","affinity","titeseq"],"organization":{"name":"MiLaboratories Inc","url":"https://milaboratories.com/","logo":{"type":"relative","path":"organization-logo.png"}}},"featureFlags":{"supportsLazyState":true,"supportsPframeQueryRanking":true,"requiresUIAPIVersion":3,"requiresModelAPIVersion":2,"requiresCreatePTable":2,"requiresPFramesVersion":1001031,"requiresPFrameSpec":true,"requiresPFrame":true,"requiresDialog":true,"requiresColumnsCollection":true},"kind":"@platforma-open/platforma-open.titeseq-analysis.kind@1.0.0"},"timestamp":1790673661080,"files":[{"name":"main.plj.gz","size":487713,"sha256":"2AA9C956622EEAD6B391F460373FB3E598AC984599F6215339D42BF3EDDD55F6"},{"name":"model.json","size":569641,"sha256":"CABA4CEBD7AC0C683DAFACB4E181E0F7A1C24C97898243B5811464F33690C94A"},{"name":"ui.tgz","size":6323636,"sha256":"9AADC7107FAD8DBA038896EB86642A4E8CBF413504EFFEB118EF415662E19D85"},{"name":"organization-logo.png","size":24439,"sha256":"FA71390C77C91E4B7FAAE5640D00F92F1E3F2869296F68B6040DD7CC549A50B5"},{"name":"description.md","size":1056,"sha256":"9443042C86C01D016B711038FCB8D91A73EBA7205EC698950A857AA99358193B"},{"name":"CHANGELOG.md","size":27,"sha256":"3E1D1DA422E5D609FCDE7F996A81F7635011F3CA297923598DB36D924C4A0DAE"},{"name":"block-logo.png","size":21527,"sha256":"6BB33BAF0CD039549661B51AE490373BE60D1811EC71F5023400928293BC2427"}]}