@platforma-open/milaboratories.antibody-variant-designer.block 1.0.0

package/block-pack/CHANGELOG.md

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+# @platforma-open/milaboratories.antibody-variant-designer
+
+## 1.0.0
+
+Initial scaffold.

package/block-pack/description.md

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+# Overview
+
+Proposes repaired antibody variants. The block reads a predicted V-domain
+structure and its per-residue confidence from the [3D Structure
+Prediction](https://github.com/platforma-open/3d-structure-prediction) block,
+finds the chemical liability motifs, decides which of them are worth fixing
+from how solvent-exposed they are, proposes substitutions that the fold
+tolerates, and discards any proposal that fails to remove the target liability
+or that introduces a new one.
+
+Each surviving variant carries its rank within its parent antibody, the
+positions it changed, how tolerant the fold is at those positions, a
+binding-risk band, and a permanent marker that it is an unvalidated hypothesis.
+The result leaves the block as a fixed-column CSV for synthesis.
+
+Substitution tolerance comes from [AntiFold](https://doi.org/10.1093/bioadv/vbae202)
+per-position matrices, read once per antibody. No variant structure is
+predicted and no binding strength is estimated — binding is judged empirically
+in the wet lab.
+
+Supported formats: VHH, mAb, Fab, scFv. V-domain only.

package/block-pack/manifest.json

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