@pharmatools/pubcrawl 2.1.0 → 2.2.0

package/README.md

@@ -1,6 +1,6 @@
 # PubCrawl
 
-An [MCP server](https://modelcontextprotocol.io) that gives LLM clients access to PubMed, FDA drug labelling, and UK medicines data. A peer-reviewed pub crawl through the literature — and the label.
+An [MCP server](https://modelcontextprotocol.io) that gives LLM clients access to PubMed, FDA drug labelling, UK medicines data, and ClinicalTrials.gov. A peer-reviewed pub crawl through the literature — the label — and the trial.
 
 Built by [PharmaTools.AI](https://pharmatools.ai).
 
@@ -26,6 +26,13 @@ Built by [PharmaTools.AI](https://pharmatools.ai).
 | `compare_labels` | Side-by-side comparison of US (USPI) and UK (SmPC) labelling for the same drug. Spot regulatory differences in indications, warnings, and dosing. |
 | `search_by_indication` | Find drugs approved for a medical condition. Searches FDA labelling via OpenFDA, then cross-references UK availability on the eMC. |
 
+### Clinical Trials
+
+| Tool | What it does |
+|------|-------------|
+| `search_trials` | Search ClinicalTrials.gov for clinical trials. Filter by condition, intervention, recruitment status, and phase. Returns NCT IDs, sponsors, enrollment, and links. |
+| `get_trial` | Get full details for a clinical trial by NCT ID — eligibility criteria, study design, arms, primary/secondary outcomes, locations, and associated PubMed IDs. |
+
 ## Setup
 
 ### Prerequisites
@@ -114,6 +121,8 @@ Once connected, just ask naturally:
 - "Pull the UK SmPC for atorvastatin"
 - "Compare US and UK labelling for lisinopril"
 - "What drugs are approved for type 2 diabetes?"
+- "Find recruiting Phase 3 trials for pembrolizumab in breast cancer"
+- "Get details on clinical trial NCT03086486"
 
 ## Development
 

package/dist/http.d.ts

@@ -0,0 +1,3 @@
+#!/usr/bin/env node
+import "dotenv/config";
+//# sourceMappingURL=http.d.ts.map

package/dist/http.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"http.d.ts","sourceRoot":"","sources":["../src/http.ts"],"names":[],"mappings":";AACA,OAAO,eAAe,CAAC"}

package/dist/http.js

@@ -0,0 +1,84 @@
+#!/usr/bin/env node
+import "dotenv/config";
+import { createServer } from "node:http";
+import { McpServer } from "@modelcontextprotocol/sdk/server/mcp.js";
+import { StreamableHTTPServerTransport } from "@modelcontextprotocol/sdk/server/streamableHttp.js";
+import { setApiKey } from "./lib/ncbi.js";
+import { registerSearchTool } from "./tools/search.js";
+import { registerAbstractTool } from "./tools/abstract.js";
+import { registerFullTextTool } from "./tools/fulltext.js";
+import { registerRelatedTool } from "./tools/related.js";
+import { registerCiteTool } from "./tools/cite.js";
+import { registerTrendingTool } from "./tools/trending.js";
+import { registerUspiTool } from "./tools/uspi.js";
+import { registerSmpcTool } from "./tools/smpc.js";
+import { registerCompareLabelsTool } from "./tools/compare-labels.js";
+import { registerSearchIndicationTool } from "./tools/search-indication.js";
+import { registerTrialsSearchTool } from "./tools/trials-search.js";
+import { registerTrialDetailTool } from "./tools/trials-detail.js";
+// Configure NCBI API key if available (10 req/s vs 3 req/s)
+if (process.env.NCBI_API_KEY) {
+    setApiKey(process.env.NCBI_API_KEY);
+}
+function createMcpServer() {
+    const server = new McpServer({
+        name: "pubcrawl",
+        version: "2.0.0",
+    });
+    registerSearchTool(server);
+    registerAbstractTool(server);
+    registerFullTextTool(server);
+    registerRelatedTool(server);
+    registerCiteTool(server);
+    registerTrendingTool(server);
+    registerUspiTool(server);
+    registerSmpcTool(server);
+    registerCompareLabelsTool(server);
+    registerSearchIndicationTool(server);
+    registerTrialsSearchTool(server);
+    registerTrialDetailTool(server);
+    return server;
+}
+const PORT = parseInt(process.env.PORT ?? "3000", 10);
+const CORS_HEADERS = {
+    "Access-Control-Allow-Origin": "*",
+    "Access-Control-Allow-Methods": "GET, POST, OPTIONS",
+    "Access-Control-Allow-Headers": "Content-Type, Accept, Authorization, Mcp-Session-Id",
+    "Access-Control-Expose-Headers": "Mcp-Session-Id",
+};
+const httpServer = createServer(async (req, res) => {
+    const url = new URL(req.url ?? "/", `http://${req.headers.host}`);
+    // Handle CORS preflight
+    if (req.method === "OPTIONS") {
+        res.writeHead(204, CORS_HEADERS);
+        res.end();
+        return;
+    }
+    // Set CORS headers on all responses
+    for (const [key, value] of Object.entries(CORS_HEADERS)) {
+        res.setHeader(key, value);
+    }
+    // Health check endpoint
+    if (url.pathname === "/health" && req.method === "GET") {
+        res.writeHead(200, { "Content-Type": "application/json" });
+        res.end(JSON.stringify({ status: "ok", server: "pubcrawl" }));
+        return;
+    }
+    // MCP endpoint — new server + transport per request (stateless mode)
+    if (url.pathname === "/mcp") {
+        const server = createMcpServer();
+        const transport = new StreamableHTTPServerTransport({
+            sessionIdGenerator: undefined,
+        });
+        await server.connect(transport);
+        await transport.handleRequest(req, res);
+        return;
+    }
+    // 404 for everything else
+    res.writeHead(404, { "Content-Type": "application/json" });
+    res.end(JSON.stringify({ error: "Not found" }));
+});
+httpServer.listen(PORT, "0.0.0.0", () => {
+    console.error(`PubCrawl MCP server running on http://0.0.0.0:${PORT}/mcp`);
+});
+//# sourceMappingURL=http.js.map

package/dist/http.js.map

@@ -0,0 +1 @@
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package/dist/tools/abstract.d.ts.map

@@ -1 +1 @@
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+{"version":3,"file":"abstract.d.ts","sourceRoot":"","sources":["../../src/tools/abstract.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAiBpE,wBAAgB,oBAAoB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAmH5D"}

package/dist/tools/abstract.js

@@ -6,7 +6,7 @@ const schema = {
     structured: z.boolean().default(true).describe("Return structured abstract sections"),
 };
 export function registerAbstractTool(server) {
-    server.tool("get_abstract", "Get the full structured abstract and metadata for a PubMed article. Returns abstract sections (background, methods, results, conclusions), keywords, MeSH terms, and PMC ID.", schema, async (params) => {
+    server.tool("get_abstract", "Get the full structured abstract and metadata for a PubMed article. Returns abstract sections (background, methods, results, conclusions), keywords, MeSH terms, and PMC ID.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             const xml = await efetch({ id: params.pmid, rettype: "xml" });
             const parsed = parseXml(xml);

package/dist/tools/abstract.js.map

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package/dist/tools/cite.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"cite.d.ts","sourceRoot":"","sources":["../../src/tools/cite.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AA4IpE,wBAAgB,gBAAgB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAmFxD"}
+{"version":3,"file":"cite.d.ts","sourceRoot":"","sources":["../../src/tools/cite.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AA4IpE,wBAAgB,gBAAgB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAoFxD"}

package/dist/tools/cite.js

@@ -115,7 +115,7 @@ function formatBibtex(info) {
     return lines.join("\n");
 }
 export function registerCiteTool(server) {
-    server.tool("format_citation", "Format a citation for a PubMed article in APA, Vancouver, Harvard, or BibTeX style.", schema, async (params) => {
+    server.tool("format_citation", "Format a citation for a PubMed article in APA, Vancouver, Harvard, or BibTeX style.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             const xml = await efetch({ id: params.pmid, rettype: "xml" });
             const parsed = parseXml(xml);

package/dist/tools/cite.js.map

@@ -1 +1 @@
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package/dist/tools/compare-labels.d.ts

@@ -1,3 +1,11 @@
 import { McpServer } from "@modelcontextprotocol/sdk/server/mcp.js";
+import { CompareLabelsResult } from "../types.js";
+/**
+ * Build a CompareLabelsResult by fetching both labels from the shared engine and
+ * pairing equivalent sections (US LOINC <-> UK section number). Cached for 24h.
+ */
+export declare function buildCompareResult(drug: string, sections?: string[]): Promise<CompareLabelsResult | {
+    error: string;
+}>;
 export declare function registerCompareLabelsTool(server: McpServer): void;
 //# sourceMappingURL=compare-labels.d.ts.map

package/dist/tools/compare-labels.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"compare-labels.d.ts","sourceRoot":"","sources":["../../src/tools/compare-labels.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAgFpE,wBAAgB,yBAAyB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAwEjE"}
+{"version":3,"file":"compare-labels.d.ts","sourceRoot":"","sources":["../../src/tools/compare-labels.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAIpE,OAAO,EAAmB,mBAAmB,EAAE,MAAM,aAAa,CAAC;AAYnE;;;GAGG;AACH,wBAAsB,kBAAkB,CACtC,IAAI,EAAE,MAAM,EACZ,QAAQ,CAAC,EAAE,MAAM,EAAE,GAClB,OAAO,CAAC,mBAAmB,GAAG;IAAE,KAAK,EAAE,MAAM,CAAA;CAAE,CAAC,CA0ClD;AAED,wBAAgB,yBAAyB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAuBjE"}

package/dist/tools/compare-labels.js

@@ -1,7 +1,6 @@
 import { z } from "zod";
-import { searchDrugLabels, fetchSplXml } from "../lib/dailymed.js";
-import { searchEmc, fetchSmpcHtml, parseSmpcSections } from "../lib/emc.js";
-import { parseXml, parseSplSections } from "../lib/xml-parser.js";
+import { getUsLabel, getUkSmpc } from "@pharmatools/drug-data";
+import { cache, TTL } from "../lib/cache.js";
 import { filterSectionMap } from "../lib/label-mapping.js";
 const schema = {
     drug: z.string().describe("Drug name to compare across US and UK labelling"),
@@ -10,108 +9,55 @@ const schema = {
         .optional()
         .describe("Specific topics to compare (e.g., ['indications', 'adverse reactions']). Compares all mapped sections if omitted."),
 };
-async function fetchUsSections(drugName, loincCodes) {
-    const searchResults = await searchDrugLabels(drugName);
-    if (searchResults.length === 0)
-        return { sections: new Map(), source: null };
-    const drugLower = drugName.toLowerCase();
-    const sorted = [...searchResults].sort((a, b) => {
-        const aMatch = a.title.toLowerCase().includes(drugLower) ? 1 : 0;
-        const bMatch = b.title.toLowerCase().includes(drugLower) ? 1 : 0;
-        if (aMatch !== bMatch)
-            return bMatch - aMatch;
-        return b.published_date.localeCompare(a.published_date);
-    });
-    const best = sorted[0];
-    const xml = await fetchSplXml(best.setid);
-    const parsed = parseXml(xml);
-    const docComponent = parsed?.document?.component;
-    const firstComponent = Array.isArray(docComponent) ? docComponent[0] : docComponent;
-    const structuredBody = firstComponent?.structuredBody;
-    const rawSections = parseSplSections(structuredBody, loincCodes);
-    const sectionMap = new Map();
-    for (const s of rawSections) {
-        sectionMap.set(s.code, { code: s.code, title: s.title, content: s.content });
+/**
+ * Build a CompareLabelsResult by fetching both labels from the shared engine and
+ * pairing equivalent sections (US LOINC <-> UK section number). Cached for 24h.
+ */
+export async function buildCompareResult(drug, sections) {
+    const mappings = filterSectionMap(sections);
+    if (mappings.length === 0) {
+        return { error: "No matching section mappings found for the requested topics" };
     }
-    return {
-        sections: sectionMap,
-        source: `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${best.setid}`,
-    };
-}
-async function fetchUkSections(drugName, ukCodes) {
-    const searchResults = await searchEmc(drugName);
-    if (searchResults.length === 0)
-        return { sections: new Map(), source: null };
-    const drugLower = drugName.toLowerCase();
-    const sorted = [...searchResults].sort((a, b) => {
-        const aMatch = a.name.toLowerCase().includes(drugLower) ? 1 : 0;
-        const bMatch = b.name.toLowerCase().includes(drugLower) ? 1 : 0;
-        return bMatch - aMatch;
-    });
-    const best = sorted[0];
-    const html = await fetchSmpcHtml(best.product_id);
-    const rawSections = parseSmpcSections(html, ukCodes);
-    const sectionMap = new Map();
-    for (const s of rawSections) {
-        sectionMap.set(s.code, { code: s.code, title: s.title, content: s.content });
+    const cacheKey = `compare:${drug.toLowerCase()}:${(sections ?? []).join(",").toLowerCase()}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const usCodes = mappings.map((m) => m.us_loinc);
+    const ukCodes = mappings.map((m) => m.uk_code);
+    // Fetch both in parallel — allow partial results
+    const [usSettled, ukSettled] = await Promise.allSettled([
+        getUsLabel(drug, usCodes),
+        getUkSmpc(drug, ukCodes),
+    ]);
+    const us = usSettled.status === "fulfilled" ? usSettled.value : null;
+    const uk = ukSettled.status === "fulfilled" ? ukSettled.value : null;
+    if ((!us || us.sections.length === 0) && (!uk || uk.sections.length === 0)) {
+        return { error: `No labelling found for "${drug}" in either US or UK databases` };
     }
-    return {
-        sections: sectionMap,
-        source: `https://www.medicines.org.uk/emc/product/${best.product_id}/smpc`,
+    const usByCode = new Map((us?.sections ?? []).map((s) => [s.code, s]));
+    const ukByCode = new Map((uk?.sections ?? []).map((s) => [s.code, s]));
+    const comparisons = mappings.map((m) => ({
+        topic: m.topic,
+        us_section: usByCode.get(m.us_loinc) ?? null,
+        uk_section: ukByCode.get(m.uk_code) ?? null,
+    }));
+    const result = {
+        drug,
+        comparisons,
+        us_source: us?.dailymedUrl ?? null,
+        uk_source: uk?.url ?? null,
     };
+    cache.set(cacheKey, result, TTL.LABEL);
+    return result;
 }
 export function registerCompareLabelsTool(server) {
-    server.tool("compare_labels", "Compare US FDA Prescribing Information vs UK/EU SmPC for a drug side-by-side. Maps equivalent sections (e.g., US Indications ↔ UK 4.1) and returns paired content.", schema, async (params) => {
+    server.tool("compare_labels", "Compare US FDA Prescribing Information vs UK/EU SmPC for a drug side-by-side. Maps equivalent sections (e.g., US Indications ↔ UK 4.1) and returns paired content.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
-            const mappings = filterSectionMap(params.sections);
-            if (mappings.length === 0) {
-                return {
-                    content: [{
-                            type: "text",
-                            text: JSON.stringify({ error: "No matching section mappings found for the requested topics" }, null, 2),
-                        }],
-                    isError: true,
-                };
-            }
-            const loincCodes = mappings.map((m) => m.us_loinc);
-            const ukCodes = mappings.map((m) => m.uk_code);
-            // Fetch both in parallel — allow partial results
-            const [usResult, ukResult] = await Promise.allSettled([
-                fetchUsSections(params.drug, loincCodes),
-                fetchUkSections(params.drug, ukCodes),
-            ]);
-            const us = usResult.status === "fulfilled" ? usResult.value : { sections: new Map(), source: null };
-            const uk = ukResult.status === "fulfilled" ? ukResult.value : { sections: new Map(), source: null };
-            if (us.sections.size === 0 && uk.sections.size === 0) {
-                const errors = [];
-                if (usResult.status === "rejected")
-                    errors.push(`US: ${usResult.reason}`);
-                if (ukResult.status === "rejected")
-                    errors.push(`UK: ${ukResult.reason}`);
-                return {
-                    content: [{
-                            type: "text",
-                            text: JSON.stringify({
-                                error: `No labelling found for "${params.drug}" in either US or UK databases`,
-                                details: errors.length > 0 ? errors : undefined,
-                            }, null, 2),
-                        }],
-                    isError: true,
-                };
-            }
-            const comparisons = mappings.map((mapping) => ({
-                topic: mapping.topic,
-                us_section: us.sections.get(mapping.us_loinc) ?? null,
-                uk_section: uk.sections.get(mapping.uk_code) ?? null,
-            }));
-            const result = {
-                drug: params.drug,
-                comparisons,
-                us_source: us.source,
-                uk_source: uk.source,
-            };
+            const result = await buildCompareResult(params.drug, params.sections);
+            const isError = "error" in result;
             return {
                 content: [{ type: "text", text: JSON.stringify(result, null, 2) }],
+                ...(isError ? { isError: true } : {}),
             };
         }
         catch (error) {

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+{"version":3,"file":"compare-labels.js","sourceRoot":"","sources":["../../src/tools/compare-labels.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,CAAC,EAAE,MAAM,KAAK,CAAC;AAExB,OAAO,EAAE,UAAU,EAAE,SAAS,EAAE,MAAM,wBAAwB,CAAC;AAC/D,OAAO,EAAE,KAAK,EAAE,GAAG,EAAE,MAAM,iBAAiB,CAAC;AAC7C,OAAO,EAAE,gBAAgB,EAAE,MAAM,yBAAyB,CAAC;AAG3D,MAAM,MAAM,GAAG;IACb,IAAI,EAAE,CAAC,CAAC,MAAM,EAAE,CAAC,QAAQ,CAAC,iDAAiD,CAAC;IAC5E,QAAQ,EAAE,CAAC;SACR,KAAK,CAAC,CAAC,CAAC,MAAM,EAAE,CAAC;SACjB,QAAQ,EAAE;SACV,QAAQ,CACP,mHAAmH,CACpH;CACJ,CAAC;AAEF;;;GAGG;AACH,MAAM,CAAC,KAAK,UAAU,kBAAkB,CACtC,IAAY,EACZ,QAAmB;IAEnB,MAAM,QAAQ,GAAG,gBAAgB,CAAC,QAAQ,CAAC,CAAC;IAC5C,IAAI,QAAQ,CAAC,MAAM,KAAK,CAAC,EAAE,CAAC;QAC1B,OAAO,EAAE,KAAK,EAAE,6DAA6D,EAAE,CAAC;IAClF,CAAC;IAED,MAAM,QAAQ,GAAG,WAAW,IAAI,CAAC,WAAW,EAAE,IAAI,CAAC,QAAQ,IAAI,EAAE,CAAC,CAAC,IAAI,CAAC,GAAG,CAAC,CAAC,WAAW,EAAE,EAAE,CAAC;IAC7F,MAAM,MAAM,GAAG,KAAK,CAAC,GAAG,CAAsB,QAAQ,CAAC,CAAC;IACxD,IAAI,MAAM;QAAE,OAAO,MAAM,CAAC;IAE1B,MAAM,OAAO,GAAG,QAAQ,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,QAAQ,CAAC,CAAC;IAChD,MAAM,OAAO,GAAG,QAAQ,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,OAAO,CAAC,CAAC;IAE/C,iDAAiD;IACjD,MAAM,CAAC,SAAS,EAAE,SAAS,CAAC,GAAG,MAAM,OAAO,CAAC,UAAU,CAAC;QACtD,UAAU,CAAC,IAAI,EAAE,OAAO,CAAC;QACzB,SAAS,CAAC,IAAI,EAAE,OAAO,CAAC;KACzB,CAAC,CAAC;IACH,MAAM,EAAE,GAAG,SAAS,CAAC,MAAM,KAAK,WAAW,CAAC,CAAC,CAAC,SAAS,CAAC,KAAK,CAAC,CAAC,CAAC,IAAI,CAAC;IACrE,MAAM,EAAE,GAAG,SAAS,CAAC,MAAM,KAAK,WAAW,CAAC,CAAC,CAAC,SAAS,CAAC,KAAK,CAAC,CAAC,CAAC,IAAI,CAAC;IAErE,IAAI,CAAC,CAAC,EAAE,IAAI,EAAE,CAAC,QAAQ,CAAC,MAAM,KAAK,CAAC,CAAC,IAAI,CAAC,CAAC,EAAE,IAAI,EAAE,CAAC,QAAQ,CAAC,MAAM,KAAK,CAAC,CAAC,EAAE,CAAC;QAC3E,OAAO,EAAE,KAAK,EAAE,2BAA2B,IAAI,gCAAgC,EAAE,CAAC;IACpF,CAAC;IAED,MAAM,QAAQ,GAAG,IAAI,GAAG,CAAC,CAAC,EAAE,EAAE,QAAQ,IAAI,EAAE,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,CAAC,IAAI,EAAE,CAAC,CAAC,CAAC,CAAC,CAAC;IACvE,MAAM,QAAQ,GAAG,IAAI,GAAG,CAAC,CAAC,EAAE,EAAE,QAAQ,IAAI,EAAE,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC,CAAC,CAAC,IAAI,EAAE,CAAC,CAAC,CAAC,CAAC,CAAC;IAEvE,MAAM,WAAW,GAAsB,QAAQ,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,CAAC;QAC1D,KAAK,EAAE,CAAC,CAAC,KAAK;QACd,UAAU,EAAE,QAAQ,CAAC,GAAG,CAAC,CAAC,CAAC,QAAQ,CAAC,IAAI,IAAI;QAC5C,UAAU,EAAE,QAAQ,CAAC,GAAG,CAAC,CAAC,CAAC,OAAO,CAAC,IAAI,IAAI;KAC5C,CAAC,CAAC,CAAC;IAEJ,MAAM,MAAM,GAAwB;QAClC,IAAI;QACJ,WAAW;QACX,SAAS,EAAE,EAAE,EAAE,WAAW,IAAI,IAAI;QAClC,SAAS,EAAE,EAAE,EAAE,GAAG,IAAI,IAAI;KAC3B,CAAC;IACF,KAAK,CAAC,GAAG,CAAC,QAAQ,EAAE,MAAM,EAAE,GAAG,CAAC,KAAK,CAAC,CAAC;IACvC,OAAO,MAAM,CAAC;AAChB,CAAC;AAED,MAAM,UAAU,yBAAyB,CAAC,MAAiB;IACzD,MAAM,CAAC,IAAI,CACT,gBAAgB,EAChB,oKAAoK,EACpK,MAAM,EACN,EAAE,YAAY,EAAE,IAAI,EAAE,eAAe,EAAE,KAAK,EAAE,aAAa,EAAE,IAAI,EAAE,EACnE,KAAK,EAAE,MAAM,EAAE,EAAE;QACf,IAAI,CAAC;YACH,MAAM,MAAM,GAAG,MAAM,kBAAkB,CAAC,MAAM,CAAC,IAAI,EAAE,MAAM,CAAC,QAAQ,CAAC,CAAC;YACtE,MAAM,OAAO,GAAG,OAAO,IAAI,MAAM,CAAC;YAClC,OAAO;gBACL,OAAO,EAAE,CAAC,EAAE,IAAI,EAAE,MAAM,EAAE,IAAI,EAAE,IAAI,CAAC,SAAS,CAAC,MAAM,EAAE,IAAI,EAAE,CAAC,CAAC,EAAE,CAAC;gBAClE,GAAG,CAAC,OAAO,CAAC,CAAC,CAAC,EAAE,OAAO,EAAE,IAAI,EAAE,CAAC,CAAC,CAAC,EAAE,CAAC;aACtC,CAAC;QACJ,CAAC;QAAC,OAAO,KAAK,EAAE,CAAC;YACf,MAAM,OAAO,GAAG,KAAK,YAAY,KAAK,CAAC,CAAC,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YACvE,OAAO;gBACL,OAAO,EAAE,CAAC,EAAE,IAAI,EAAE,MAAM,EAAE,IAAI,EAAE,2BAA2B,OAAO,EAAE,EAAE,CAAC;gBACvE,OAAO,EAAE,IAAI;aACd,CAAC;QACJ,CAAC;IACH,CAAC,CACF,CAAC;AACJ,CAAC"}

package/dist/tools/fulltext.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"fulltext.d.ts","sourceRoot":"","sources":["../../src/tools/fulltext.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAkBpE,wBAAgB,oBAAoB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAiG5D"}
+{"version":3,"file":"fulltext.d.ts","sourceRoot":"","sources":["../../src/tools/fulltext.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAkBpE,wBAAgB,oBAAoB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAkG5D"}

package/dist/tools/fulltext.js

@@ -7,7 +7,7 @@ const schema = {
     sections: z.array(z.string()).optional().describe("Filter to specific section titles"),
 };
 export function registerFullTextTool(server) {
-    server.tool("get_full_text", "Get the full text of an open-access article from PubMed Central. Returns article sections, figure/table captions, and reference count. Only works for articles available in PMC.", schema, async (params) => {
+    server.tool("get_full_text", "Get the full text of an open-access article from PubMed Central. Returns article sections, figure/table captions, and reference count. Only works for articles available in PMC.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             if (!params.pmid && !params.pmcid) {
                 return {

package/dist/tools/fulltext.js.map

@@ -1 +1 @@
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package/dist/tools/related.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"related.d.ts","sourceRoot":"","sources":["../../src/tools/related.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAUpE,wBAAgB,mBAAmB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAgE3D"}
+{"version":3,"file":"related.d.ts","sourceRoot":"","sources":["../../src/tools/related.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAUpE,wBAAgB,mBAAmB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAiE3D"}

package/dist/tools/related.js

@@ -6,7 +6,7 @@ const schema = {
     maxResults: z.number().min(1).max(100).default(10).describe("Maximum number of results"),
 };
 export function registerRelatedTool(server) {
-    server.tool("find_related", "Find related articles for a given PubMed article. Returns similar papers ranked by relevance score using PubMed's neighbor algorithm.", schema, async (params) => {
+    server.tool("find_related", "Find related articles for a given PubMed article. Returns similar papers ranked by relevance score using PubMed's neighbor algorithm.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             const linkResult = await elink({
                 id: params.pmid,

package/dist/tools/related.js.map

@@ -1 +1 @@
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package/dist/tools/search-indication.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"search-indication.d.ts","sourceRoot":"","sources":["../../src/tools/search-indication.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAgCpE,wBAAgB,4BAA4B,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CA4DpE"}
+{"version":3,"file":"search-indication.d.ts","sourceRoot":"","sources":["../../src/tools/search-indication.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAgCpE,wBAAgB,4BAA4B,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CA6DpE"}

package/dist/tools/search-indication.js

@@ -22,7 +22,7 @@ const schema = {
     maxResults: z.number().min(1).max(50).default(10).describe("Maximum number of drug results to return"),
 };
 export function registerSearchIndicationTool(server) {
-    server.tool("search_by_indication", "Find drugs approved for a medical condition. Searches US FDA labelling for the condition, then checks UK (eMC) availability for each drug found.", schema, async (params) => {
+    server.tool("search_by_indication", "Find drugs approved for a medical condition. Searches US FDA labelling for the condition, then checks UK (eMC) availability for each drug found.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             // Step 1: Search OpenFDA for drugs with this indication
             const fdaDrugs = await searchByIndication(params.condition, params.maxResults);

package/dist/tools/search-indication.js.map

@@ -1 +1 @@
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package/dist/tools/search.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"search.d.ts","sourceRoot":"","sources":["../../src/tools/search.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAiCpE,wBAAgB,kBAAkB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAgD1D"}
+{"version":3,"file":"search.d.ts","sourceRoot":"","sources":["../../src/tools/search.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAiCpE,wBAAgB,kBAAkB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAiD1D"}

package/dist/tools/search.js

@@ -27,7 +27,7 @@ function formatArticle(uid, doc) {
     };
 }
 export function registerSearchTool(server) {
-    server.tool("search_pubmed", "Search PubMed for biomedical literature. Returns article summaries with PMIDs, titles, authors, journals, and DOIs.", schema, async (params) => {
+    server.tool("search_pubmed", "Search PubMed for biomedical literature. Returns article summaries with PMIDs, titles, authors, journals, and DOIs.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             let term = params.query;
             if (params.articleType) {

package/dist/tools/search.js.map

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package/dist/tools/smpc.d.ts

@@ -1,3 +1,11 @@
 import { McpServer } from "@modelcontextprotocol/sdk/server/mcp.js";
+import { SmPCResult } from "../types.js";
+/**
+ * Build an SmPCResult from the shared drug-data engine (eMC). Result-shape
+ * compatible with the previous implementation. Cached for 24h.
+ */
+export declare function buildSmpcResult(drug: string, sections?: string[]): Promise<SmPCResult | {
+    error: string;
+}>;
 export declare function registerSmpcTool(server: McpServer): void;
 //# sourceMappingURL=smpc.d.ts.map

package/dist/tools/smpc.d.ts.map

@@ -1 +1 @@
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+{"version":3,"file":"smpc.d.ts","sourceRoot":"","sources":["../../src/tools/smpc.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAGpE,OAAO,EAAE,UAAU,EAAE,MAAM,aAAa,CAAC;AAYzC;;;GAGG;AACH,wBAAsB,eAAe,CACnC,IAAI,EAAE,MAAM,EACZ,QAAQ,CAAC,EAAE,MAAM,EAAE,GAClB,OAAO,CAAC,UAAU,GAAG;IAAE,KAAK,EAAE,MAAM,CAAA;CAAE,CAAC,CAkBzC;AAED,wBAAgB,gBAAgB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAuBxD"}

package/dist/tools/smpc.js

@@ -1,5 +1,6 @@
 import { z } from "zod";
-import { searchEmc, fetchSmpcHtml, parseSmpcSections } from "../lib/emc.js";
+import { getUkSmpc } from "@pharmatools/drug-data";
+import { cache, TTL } from "../lib/cache.js";
 const schema = {
     drug: z.string().describe("Drug name to look up (e.g., 'metformin', 'atorvastatin')"),
     sections: z
@@ -7,37 +8,36 @@ const schema = {
         .optional()
         .describe("Specific sections to retrieve — accepts numbers like '4.1' or names like 'indications'. Returns all sections if omitted."),
 };
+/**
+ * Build an SmPCResult from the shared drug-data engine (eMC). Result-shape
+ * compatible with the previous implementation. Cached for 24h.
+ */
+export async function buildSmpcResult(drug, sections) {
+    const cacheKey = `smpc:${drug.toLowerCase()}:${(sections ?? []).join(",").toLowerCase()}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const smpc = await getUkSmpc(drug, sections);
+    if (!smpc || smpc.sections.length === 0) {
+        return { error: `No SmPC found for "${drug}" on eMC` };
+    }
+    const result = {
+        drug_name: smpc.drugName,
+        product_id: smpc.productId,
+        sections: smpc.sections,
+        url: smpc.url,
+    };
+    cache.set(cacheKey, result, TTL.LABEL);
+    return result;
+}
 export function registerSmpcTool(server) {
-    server.tool("get_smpc", "Get UK/EU Summary of Product Characteristics (SmPC) for a drug from eMC (medicines.org.uk). Returns structured labelling sections.", schema, async (params) => {
+    server.tool("get_smpc", "Get UK/EU Summary of Product Characteristics (SmPC) for a drug from eMC (medicines.org.uk). Returns structured labelling sections.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
-            const searchResults = await searchEmc(params.drug);
-            if (searchResults.length === 0) {
-                return {
-                    content: [{
-                            type: "text",
-                            text: JSON.stringify({ error: `No SmPC found for "${params.drug}" on eMC` }, null, 2),
-                        }],
-                    isError: true,
-                };
-            }
-            // Select best match: prefer name containing the drug
-            const drugLower = params.drug.toLowerCase();
-            const sorted = [...searchResults].sort((a, b) => {
-                const aMatch = a.name.toLowerCase().includes(drugLower) ? 1 : 0;
-                const bMatch = b.name.toLowerCase().includes(drugLower) ? 1 : 0;
-                return bMatch - aMatch;
-            });
-            const best = sorted[0];
-            const html = await fetchSmpcHtml(best.product_id);
-            const sections = parseSmpcSections(html, params.sections);
-            const result = {
-                drug_name: best.name,
-                product_id: best.product_id,
-                sections: sections.map((s) => ({ code: s.code, title: s.title, content: s.content })),
-                url: `https://www.medicines.org.uk/emc/product/${best.product_id}/smpc`,
-            };
+            const result = await buildSmpcResult(params.drug, params.sections);
+            const isError = "error" in result;
             return {
                 content: [{ type: "text", text: JSON.stringify(result, null, 2) }],
+                ...(isError ? { isError: true } : {}),
             };
         }
         catch (error) {

package/dist/tools/smpc.js.map

@@ -1 +1 @@
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package/dist/tools/trending.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"trending.d.ts","sourceRoot":"","sources":["../../src/tools/trending.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAqCpE,wBAAgB,oBAAoB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAmF5D"}
+{"version":3,"file":"trending.d.ts","sourceRoot":"","sources":["../../src/tools/trending.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAqCpE,wBAAgB,oBAAoB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAoF5D"}

package/dist/tools/trending.js

@@ -31,7 +31,7 @@ function formatDate(date) {
     return `${y}/${m}/${d}`;
 }
 export function registerTrendingTool(server) {
-    server.tool("trending_papers", "Find recent/trending papers on a topic. Sorted by date, with optional filtering to high-impact journals.", schema, async (params) => {
+    server.tool("trending_papers", "Find recent/trending papers on a topic. Sorted by date, with optional filtering to high-impact journals.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             const now = new Date();
             const from = new Date(now.getTime() - params.days * 24 * 60 * 60 * 1000);

package/dist/tools/trending.js.map

@@ -1 +1 @@
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+{"version":3,"file":"trending.js","sourceRoot":"","sources":["../../src/tools/trending.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,CAAC,EAAE,MAAM,KAAK,CAAC;AAExB,OAAO,EAAE,OAAO,EAAE,QAAQ,EAAE,MAAM,gBAAgB,CAAC;AACnD,OAAO,EAAE,mBAAmB,EAAE,MAAM,sBAAsB,CAAC;AAG3D,MAAM,oBAAoB,GAAG;IAC3B,QAAQ;IACR,SAAS;IACT,MAAM;IACN,qCAAqC;IACrC,YAAY;IACZ,MAAM;IACN,KAAK;IACL,iBAAiB;IACjB,sBAAsB;IACtB,iBAAiB;IACjB,gBAAgB;IAChB,6BAA6B;IAC7B,eAAe;IACf,aAAa;IACb,8BAA8B;CAC/B,CAAC;AAEF,MAAM,MAAM,GAAG;IACb,KAAK,EAAE,CAAC,CAAC,MAAM,EAAE,CAAC,QAAQ,CAAC,sBAAsB,CAAC;IAClD,IAAI,EAAE,CAAC,CAAC,MAAM,EAAE,CAAC,GAAG,CAAC,CAAC,CAAC,CAAC,GAAG,CAAC,GAAG,CAAC,CAAC,OAAO,CAAC,EAAE,CAAC,CAAC,QAAQ,CAAC,6BAA6B,CAAC;IACpF,UAAU,EAAE,CAAC,CAAC,MAAM,EAAE,CAAC,GAAG,CAAC,CAAC,CAAC,CAAC,GAAG,CAAC,GAAG,CAAC,CAAC,OAAO,CAAC,EAAE,CAAC,CAAC,QAAQ,CAAC,2BAA2B,CAAC;IACxF,cAAc,EAAE,CAAC,CAAC,OAAO,EAAE,CAAC,OAAO,CAAC,KAAK,CAAC,CAAC,QAAQ,CAAC,qCAAqC,CAAC;CAC3F,CAAC;AAEF,SAAS,UAAU,CAAC,IAAU;IAC5B,MAAM,CAAC,GAAG,IAAI,CAAC,WAAW,EAAE,CAAC;IAC7B,MAAM,CAAC,GAAG,MAAM,CAAC,IAAI,CAAC,QAAQ,EAAE,GAAG,CAAC,CAAC,CAAC,QAAQ,CAAC,CAAC,EAAE,GAAG,CAAC,CAAC;IACvD,MAAM,CAAC,GAAG,MAAM,CAAC,IAAI,CAAC,OAAO,EAAE,CAAC,CAAC,QAAQ,CAAC,CAAC,EAAE,GAAG,CAAC,CAAC;IAClD,OAAO,GAAG,CAAC,IAAI,CAAC,IAAI,CAAC,EAAE,CAAC;AAC1B,CAAC;AAED,MAAM,UAAU,oBAAoB,CAAC,MAAiB;IACpD,MAAM,CAAC,IAAI,CACT,iBAAiB,EACjB,0GAA0G,EAC1G,MAAM,EACN,EAAE,YAAY,EAAE,IAAI,EAAE,eAAe,EAAE,KAAK,EAAE,aAAa,EAAE,IAAI,EAAE,EACnE,KAAK,EAAE,MAAM,EAAE,EAAE;QACf,IAAI,CAAC;YACH,MAAM,GAAG,GAAG,IAAI,IAAI,EAAE,CAAC;YACvB,MAAM,IAAI,GAAG,IAAI,IAAI,CAAC,GAAG,CAAC,OAAO,EAAE,GAAG,MAAM,CAAC,IAAI,GAAG,EAAE,GAAG,EAAE,GAAG,EAAE,GAAG,IAAI,CAAC,CAAC;YAEzE,IAAI,IAAI,GAAG,MAAM,CAAC,KAAK,CAAC;YACxB,IAAI,MAAM,CAAC,cAAc,EAAE,CAAC;gBAC1B,MAAM,aAAa,GAAG,oBAAoB;qBACvC,GAAG,CAAC,CAAC,CAAC,EAAE,EAAE,CAAC,IAAI,CAAC,YAAY,CAAC;qBAC7B,IAAI,CAAC,MAAM,CAAC,CAAC;gBAChB,IAAI,IAAI,SAAS,aAAa,GAAG,CAAC;YACpC,CAAC;YAED,MAAM,YAAY,GAAG,MAAM,OAAO,CAAC;gBACjC,IAAI;gBACJ,MAAM,EAAE,MAAM,CAAC,UAAU;gBACzB,IAAI,EAAE,UAAU;gBAChB,QAAQ,EAAE,MAAM;gBAChB,OAAO,EAAE,UAAU,CAAC,IAAI,CAAC;gBACzB,OAAO,EAAE,UAAU,CAAC,GAAG,CAAC;aACzB,CAAC,CAAC;YAEH,IAAI,YAAY,CAAC,MAAM,CAAC,MAAM,KAAK,CAAC,EAAE,CAAC;gBACrC,OAAO;oBACL,OAAO,EAAE,CAAC;4BACR,IAAI,EAAE,MAAM;4BACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAAC;gCACnB,OAAO,EAAE,EAAE;gCACX,WAAW,EAAE,CAAC;gCACd,KAAK,EAAE,MAAM,CAAC,KAAK;gCACnB,WAAW,EAAE,MAAM,CAAC,IAAI;6BACzB,EAAE,IAAI,EAAE,CAAC,CAAC;yBACZ,CAAC;iBACH,CAAC;YACJ,CAAC;YAED,MAAM,WAAW,GAAG,MAAM,QAAQ,CAAC,EAAE,EAAE,EAAE,YAAY,CAAC,MAAM,EAAE,CAAC,CAAC;YAEhE,MAAM,QAAQ,GAAoB,YAAY,CAAC,MAAM;iBAClD,MAAM,CAAC,CAAC,GAAG,EAAE,EAAE,CAAC,WAAW,CAAC,GAAG,CAAC,CAAC;iBACjC,GAAG,CAAC,CAAC,GAAG,EAAE,EAAE;gBACX,MAAM,GAAG,GAAG,WAAW,CAAC,GAAG,CAA4B,CAAC;gBACxD,MAAM,OAAO,GAAG,mBAAmB,CAAC,GAAG,CAAC,OAAO,CAAC,CAAC;gBACjD,MAAM,OAAO,GAAG,MAAM,CAAC,GAAG,CAAC,OAAO,IAAI,EAAE,CAAC,CAAC;gBAC1C,MAAM,IAAI,GAAG,OAAO,CAAC,KAAK,CAAC,OAAO,CAAC,EAAE,CAAC,CAAC,CAAC,IAAI,EAAE,CAAC;gBAC/C,MAAM,GAAG,GAAG,CAAC,GAAG,CAAC,WAAW,IAAI,EAAE,CAAC,CAAC,QAAQ,EAAE,CAAC,OAAO,CAAC,WAAW,EAAE,EAAE,CAAC,CAAC;gBAExE,OAAO;oBACL,IAAI,EAAE,GAAG;oBACT,KAAK,EAAE,MAAM,CAAC,GAAG,CAAC,KAAK,IAAI,EAAE,CAAC;oBAC9B,OAAO;oBACP,OAAO,EAAE,MAAM,CAAC,GAAG,CAAC,eAAe,IAAI,GAAG,CAAC,MAAM,IAAI,EAAE,CAAC;oBACxD,IAAI;oBACJ,GAAG;oBACH,gBAAgB,EAAE,MAAM,CAAC,GAAG,CAAC,SAAS,IAAI,EAAE,CAAC,CAAC,KAAK,CAAC,CAAC,EAAE,GAAG,CAAC;iBAC5D,CAAC;YACJ,CAAC,CAAC,CAAC;YAEL,OAAO;gBACL,OAAO,EAAE,CAAC;wBACR,IAAI,EAAE,MAAM;wBACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAAC;4BACnB,OAAO,EAAE,QAAQ;4BACjB,WAAW,EAAE,YAAY,CAAC,KAAK;4BAC/B,KAAK,EAAE,MAAM,CAAC,KAAK;4BACnB,WAAW,EAAE,MAAM,CAAC,IAAI;yBACzB,EAAE,IAAI,EAAE,CAAC,CAAC;qBACZ,CAAC;aACH,CAAC;QACJ,CAAC;QAAC,OAAO,KAAK,EAAE,CAAC;YACf,MAAM,OAAO,GAAG,KAAK,YAAY,KAAK,CAAC,CAAC,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YACvE,OAAO;gBACL,OAAO,EAAE,CAAC,EAAE,IAAI,EAAE,MAAM,EAAE,IAAI,EAAE,kCAAkC,OAAO,EAAE,EAAE,CAAC;gBAC9E,OAAO,EAAE,IAAI;aACd,CAAC;QACJ,CAAC;IACH,CAAC,CACF,CAAC;AACJ,CAAC"}

package/dist/tools/trials-detail.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"trials-detail.d.ts","sourceRoot":"","sources":["../../src/tools/trials-detail.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAUpE,wBAAgB,uBAAuB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAuC/D"}
+{"version":3,"file":"trials-detail.d.ts","sourceRoot":"","sources":["../../src/tools/trials-detail.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAUpE,wBAAgB,uBAAuB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAwC/D"}

package/dist/tools/trials-detail.js

@@ -7,7 +7,7 @@ const schema = {
         .describe("ClinicalTrials.gov NCT identifier (e.g., NCT03086486)"),
 };
 export function registerTrialDetailTool(server) {
-    server.tool("get_trial", "Get detailed information about a specific clinical trial from ClinicalTrials.gov. Returns eligibility criteria, study design, arms, outcomes, locations, and associated PubMed IDs.", schema, async (params) => {
+    server.tool("get_trial", "Get detailed information about a specific clinical trial from ClinicalTrials.gov. Returns eligibility criteria, study design, arms, outcomes, locations, and associated PubMed IDs.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             const detail = await getTrialDetail(params.nctId);
             return {

package/dist/tools/trials-detail.js.map

@@ -1 +1 @@
-{"version":3,"file":"trials-detail.js","sourceRoot":"","sources":["../../src/tools/trials-detail.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,CAAC,EAAE,MAAM,KAAK,CAAC;AAExB,OAAO,EAAE,cAAc,EAAE,MAAM,0BAA0B,CAAC;AAE1D,MAAM,MAAM,GAAG;IACb,KAAK,EAAE,CAAC;SACL,MAAM,EAAE;SACR,KAAK,CAAC,YAAY,EAAE,4CAA4C,CAAC;SACjE,QAAQ,CAAC,uDAAuD,CAAC;CACrE,CAAC;AAEF,MAAM,UAAU,uBAAuB,CAAC,MAAiB;IACvD,MAAM,CAAC,IAAI,CACT,WAAW,EACX,qLAAqL,EACrL,MAAM,EACN,KAAK,EAAE,MAAM,EAAE,EAAE;QACf,IAAI,CAAC;YACH,MAAM,MAAM,GAAG,MAAM,cAAc,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YAElD,OAAO;gBACL,OAAO,EAAE,CAAC;wBACR,IAAI,EAAE,MAAM;wBACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAAC,MAAM,EAAE,IAAI,EAAE,CAAC,CAAC;qBACtC,CAAC;aACH,CAAC;QACJ,CAAC;QAAC,OAAO,KAAK,EAAE,CAAC;YACf,MAAM,OAAO,GAAG,KAAK,YAAY,KAAK,CAAC,CAAC,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YAEvE,IAAI,OAAO,CAAC,QAAQ,CAAC,KAAK,CAAC,EAAE,CAAC;gBAC5B,OAAO;oBACL,OAAO,EAAE,CAAC;4BACR,IAAI,EAAE,MAAM;4BACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAClB,EAAE,KAAK,EAAE,kBAAkB,MAAM,CAAC,KAAK,2CAA2C,EAAE,EACpF,IAAI,EACJ,CAAC,CACF;yBACF,CAAC;oBACF,OAAO,EAAE,IAAI;iBACd,CAAC;YACJ,CAAC;YAED,OAAO;gBACL,OAAO,EAAE,CAAC,EAAE,IAAI,EAAE,MAAM,EAAE,IAAI,EAAE,iCAAiC,OAAO,EAAE,EAAE,CAAC;gBAC7E,OAAO,EAAE,IAAI;aACd,CAAC;QACJ,CAAC;IACH,CAAC,CACF,CAAC;AACJ,CAAC"}
+{"version":3,"file":"trials-detail.js","sourceRoot":"","sources":["../../src/tools/trials-detail.ts"],"names":[],"mappings":"AAAA,OAAO,EAAE,CAAC,EAAE,MAAM,KAAK,CAAC;AAExB,OAAO,EAAE,cAAc,EAAE,MAAM,0BAA0B,CAAC;AAE1D,MAAM,MAAM,GAAG;IACb,KAAK,EAAE,CAAC;SACL,MAAM,EAAE;SACR,KAAK,CAAC,YAAY,EAAE,4CAA4C,CAAC;SACjE,QAAQ,CAAC,uDAAuD,CAAC;CACrE,CAAC;AAEF,MAAM,UAAU,uBAAuB,CAAC,MAAiB;IACvD,MAAM,CAAC,IAAI,CACT,WAAW,EACX,qLAAqL,EACrL,MAAM,EACN,EAAE,YAAY,EAAE,IAAI,EAAE,eAAe,EAAE,KAAK,EAAE,aAAa,EAAE,IAAI,EAAE,EACnE,KAAK,EAAE,MAAM,EAAE,EAAE;QACf,IAAI,CAAC;YACH,MAAM,MAAM,GAAG,MAAM,cAAc,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YAElD,OAAO;gBACL,OAAO,EAAE,CAAC;wBACR,IAAI,EAAE,MAAM;wBACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAAC,MAAM,EAAE,IAAI,EAAE,CAAC,CAAC;qBACtC,CAAC;aACH,CAAC;QACJ,CAAC;QAAC,OAAO,KAAK,EAAE,CAAC;YACf,MAAM,OAAO,GAAG,KAAK,YAAY,KAAK,CAAC,CAAC,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,MAAM,CAAC,KAAK,CAAC,CAAC;YAEvE,IAAI,OAAO,CAAC,QAAQ,CAAC,KAAK,CAAC,EAAE,CAAC;gBAC5B,OAAO;oBACL,OAAO,EAAE,CAAC;4BACR,IAAI,EAAE,MAAM;4BACZ,IAAI,EAAE,IAAI,CAAC,SAAS,CAClB,EAAE,KAAK,EAAE,kBAAkB,MAAM,CAAC,KAAK,2CAA2C,EAAE,EACpF,IAAI,EACJ,CAAC,CACF;yBACF,CAAC;oBACF,OAAO,EAAE,IAAI;iBACd,CAAC;YACJ,CAAC;YAED,OAAO;gBACL,OAAO,EAAE,CAAC,EAAE,IAAI,EAAE,MAAM,EAAE,IAAI,EAAE,iCAAiC,OAAO,EAAE,EAAE,CAAC;gBAC7E,OAAO,EAAE,IAAI;aACd,CAAC;QACJ,CAAC;IACH,CAAC,CACF,CAAC;AACJ,CAAC"}

package/dist/tools/trials-search.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"trials-search.d.ts","sourceRoot":"","sources":["../../src/tools/trials-search.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AA8BpE,wBAAgB,wBAAwB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CA8ChE"}
+{"version":3,"file":"trials-search.d.ts","sourceRoot":"","sources":["../../src/tools/trials-search.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AA8BpE,wBAAgB,wBAAwB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CA+ChE"}

package/dist/tools/trials-search.js

@@ -27,7 +27,7 @@ const schema = {
         .describe("Sort order for results"),
 };
 export function registerTrialsSearchTool(server) {
-    server.tool("search_trials", "Search ClinicalTrials.gov for clinical trials. Filter by condition, intervention, status, and phase. Returns trial summaries with NCT IDs, status, sponsors, and enrollment info.", schema, async (params) => {
+    server.tool("search_trials", "Search ClinicalTrials.gov for clinical trials. Filter by condition, intervention, status, and phase. Returns trial summaries with NCT IDs, status, sponsors, and enrollment info.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
             if (!params.condition && !params.intervention && !params.term) {
                 return {

package/dist/tools/trials-search.js.map

@@ -1 +1 @@
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package/dist/tools/uspi.d.ts

@@ -1,3 +1,12 @@
 import { McpServer } from "@modelcontextprotocol/sdk/server/mcp.js";
+import { USPIResult } from "../types.js";
+/**
+ * Build a USPIResult from the shared drug-data engine (openFDA, cited to
+ * DailyMed). Result-shape compatible with the previous SPL-based implementation.
+ * Cached for 24h. Returns { error } when no label is found.
+ */
+export declare function buildUspiResult(drug: string, sections?: string[]): Promise<USPIResult | {
+    error: string;
+}>;
 export declare function registerUspiTool(server: McpServer): void;
 //# sourceMappingURL=uspi.d.ts.map

package/dist/tools/uspi.d.ts.map

@@ -1 +1 @@
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+{"version":3,"file":"uspi.d.ts","sourceRoot":"","sources":["../../src/tools/uspi.ts"],"names":[],"mappings":"AACA,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AAGpE,OAAO,EAAE,UAAU,EAAE,MAAM,aAAa,CAAC;AAYzC;;;;GAIG;AACH,wBAAsB,eAAe,CACnC,IAAI,EAAE,MAAM,EACZ,QAAQ,CAAC,EAAE,MAAM,EAAE,GAClB,OAAO,CAAC,UAAU,GAAG;IAAE,KAAK,EAAE,MAAM,CAAA;CAAE,CAAC,CAoBzC;AAED,wBAAgB,gBAAgB,CAAC,MAAM,EAAE,SAAS,GAAG,IAAI,CAuBxD"}

package/dist/tools/uspi.js

@@ -1,50 +1,6 @@
 import { z } from "zod";
-import { searchDrugLabels, fetchSplXml } from "../lib/dailymed.js";
-import { parseXml, parseSplSections } from "../lib/xml-parser.js";
-// LOINC codes for FDA prescribing information sections
-const LOINC_MAP = {
-    "boxed warning": "34071-1",
-    "indications": "34067-9",
-    "indications and usage": "34067-9",
-    "dosage": "34068-7",
-    "dosage and administration": "34068-7",
-    "dosage forms": "43678-2",
-    "contraindications": "34070-3",
-    "warnings": "43685-7",
-    "warnings and precautions": "43685-7",
-    "adverse reactions": "34084-4",
-    "drug interactions": "34073-7",
-    "use in specific populations": "42228-7",
-    "pregnancy": "42228-7",
-    "overdosage": "34088-5",
-    "clinical pharmacology": "34090-1",
-    "description": "34089-3",
-    "how supplied": "34069-5",
-    "storage": "44425-7",
-    "patient counseling": "34076-0",
-    "medication guide": "42231-1",
-};
-// All known PI LOINC codes
-const ALL_PI_CODES = [...new Set(Object.values(LOINC_MAP))];
-function resolveLoincCodes(sections) {
-    if (!sections || sections.length === 0)
-        return undefined;
-    const codes = [];
-    for (const input of sections) {
-        const lower = input.toLowerCase().trim();
-        // Direct LOINC code (e.g., "34067-9")
-        if (/^\d{5}-\d$/.test(lower)) {
-            codes.push(lower);
-            continue;
-        }
-        // Fuzzy match against section names
-        const match = Object.entries(LOINC_MAP).find(([name]) => name.includes(lower) || lower.includes(name));
-        if (match) {
-            codes.push(match[1]);
-        }
-    }
-    return codes.length > 0 ? codes : undefined;
-}
+import { getUsLabel } from "@pharmatools/drug-data";
+import { cache, TTL } from "../lib/cache.js";
 const schema = {
     drug: z.string().describe("Drug name to look up (e.g., 'metformin', 'atorvastatin')"),
     sections: z
@@ -52,57 +8,39 @@ const schema = {
         .optional()
         .describe("Specific sections to retrieve (e.g., ['indications', 'adverse reactions', 'contraindications']). Returns all sections if omitted."),
 };
+/**
+ * Build a USPIResult from the shared drug-data engine (openFDA, cited to
+ * DailyMed). Result-shape compatible with the previous SPL-based implementation.
+ * Cached for 24h. Returns { error } when no label is found.
+ */
+export async function buildUspiResult(drug, sections) {
+    const cacheKey = `uspi:${drug.toLowerCase()}:${(sections ?? []).join(",").toLowerCase()}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const label = await getUsLabel(drug, sections);
+    if (!label || label.sections.length === 0) {
+        return { error: `No FDA labelling found for "${drug}"` };
+    }
+    const result = {
+        drug_name: label.drugName,
+        setid: label.setId,
+        spl_version: "",
+        published_date: label.publishedDate,
+        sections: label.sections,
+        dailymed_url: label.dailymedUrl,
+    };
+    cache.set(cacheKey, result, TTL.LABEL);
+    return result;
+}
 export function registerUspiTool(server) {
-    server.tool("get_uspi", "Get FDA US Prescribing Information (USPI) for a drug from DailyMed. Returns structured labelling sections with LOINC codes.", schema, async (params) => {
+    server.tool("get_uspi", "Get FDA US Prescribing Information (USPI) for a drug from openFDA (cited to DailyMed). Returns structured labelling sections with LOINC codes.", schema, { readOnlyHint: true, destructiveHint: false, openWorldHint: true }, async (params) => {
         try {
-            const searchResults = await searchDrugLabels(params.drug);
-            if (searchResults.length === 0) {
-                return {
-                    content: [{
-                            type: "text",
-                            text: JSON.stringify({ error: `No FDA labelling found for "${params.drug}"` }, null, 2),
-                        }],
-                    isError: true,
-                };
-            }
-            // Select best match: filter by drug name, sort by date descending
-            const drugLower = params.drug.toLowerCase();
-            const sorted = [...searchResults].sort((a, b) => {
-                const aMatch = a.title.toLowerCase().includes(drugLower) ? 1 : 0;
-                const bMatch = b.title.toLowerCase().includes(drugLower) ? 1 : 0;
-                if (aMatch !== bMatch)
-                    return bMatch - aMatch;
-                return b.published_date.localeCompare(a.published_date);
-            });
-            const best = sorted[0];
-            const xml = await fetchSplXml(best.setid);
-            const parsed = parseXml(xml);
-            // Navigate SPL XML structure: document > component > structuredBody
-            // component may be an array due to XML parser isArray config
-            const document = parsed?.document;
-            const docComponent = document?.component;
-            const firstComponent = Array.isArray(docComponent) ? docComponent[0] : docComponent;
-            const structuredBody = firstComponent?.structuredBody;
-            const requestedCodes = resolveLoincCodes(params.sections);
-            const rawSections = parseSplSections(structuredBody, requestedCodes);
-            // If no specific sections requested and we got nothing from filtering, try all PI codes
-            const sections = rawSections.length > 0
-                ? rawSections.map((s) => ({ code: s.code, title: s.title, content: s.content }))
-                : parseSplSections(structuredBody, ALL_PI_CODES).map((s) => ({
-                    code: s.code,
-                    title: s.title,
-                    content: s.content,
-                }));
-            const result = {
-                drug_name: best.title,
-                setid: best.setid,
-                spl_version: best.spl_version,
-                published_date: best.published_date,
-                sections,
-                dailymed_url: `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${best.setid}`,
-            };
+            const result = await buildUspiResult(params.drug, params.sections);
+            const isError = "error" in result;
             return {
                 content: [{ type: "text", text: JSON.stringify(result, null, 2) }],
+                ...(isError ? { isError: true } : {}),
             };
         }
         catch (error) {

package/dist/tools/uspi.js.map

@@ -1 +1 @@
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package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@pharmatools/pubcrawl",
-  "version": "2.1.0",
+  "version": "2.2.0",
   "description": "MCP server for PubMed literature search and US/UK drug labelling — built by PharmaTools.AI",
   "mcpName": "io.github.nickjlamb/pubcrawl",
   "author": "PharmaTools.AI",
@@ -29,11 +29,13 @@
   "scripts": {
     "build": "tsc",
     "start": "node dist/index.js",
+    "start:http": "node dist/http.js",
     "dev": "tsc --watch",
     "prepublishOnly": "npm run build"
   },
   "dependencies": {
     "@modelcontextprotocol/sdk": "^1.0.0",
+    "@pharmatools/drug-data": "^0.2.0",
     "cheerio": "^1.2.0",
     "dotenv": "^16.0.0",
     "fast-xml-parser": "^4.3.0"
@@ -42,6 +44,9 @@
     "@types/node": "^20.0.0",
     "typescript": "^5.3.0"
   },
+  "engines": {
+    "node": ">=20"
+  },
   "repository": {
     "type": "git",
     "url": "https://github.com/nickjlamb/pubcrawl"