@pharmatools/pubcrawl 2.0.0

package/LICENSE

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+MIT License
+
+Copyright (c) 2026 PharmaTools.AI
+
+Permission is hereby granted, free of charge, to any person obtaining a copy
+of this software and associated documentation files (the "Software"), to deal
+in the Software without restriction, including without limitation the rights
+to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+copies of the Software, and to permit persons to whom the Software is
+furnished to do so, subject to the following conditions:
+
+The above copyright notice and this permission notice shall be included in all
+copies or substantial portions of the Software.
+
+THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
+AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
+SOFTWARE.

package/README.md

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+# PubCrawl
+
+An [MCP server](https://modelcontextprotocol.io) that gives LLM clients access to PubMed, FDA drug labelling, and UK medicines data. A peer-reviewed pub crawl through the literature — and the label.
+
+Built by [PharmaTools.AI](https://pharmatools.ai).
+
+## Tools
+
+### Literature
+
+| Tool | What it does |
+|------|-------------|
+| `search_pubmed` | Search PubMed with filters for date range, article type, and sort order. Returns PMIDs, titles, authors, journals, and DOIs. |
+| `get_abstract` | Get the full structured abstract for an article — broken into labeled sections (background, methods, results, conclusions) with keywords and MeSH terms. |
+| `get_full_text` | Retrieve the full text of open-access articles from PubMed Central, with parsed sections, figure/table captions, and reference counts. |
+| `find_related` | Find similar articles using PubMed's neighbor algorithm, ranked by relevance score. |
+| `format_citation` | Generate a formatted citation in APA, Vancouver, Harvard, or BibTeX style. |
+| `trending_papers` | Find recent papers on a topic, with optional filtering to high-impact journals (Nature, Science, Cell, NEJM, Lancet, JAMA, etc.). |
+
+### Drug Labelling
+
+| Tool | What it does |
+|------|-------------|
+| `get_uspi` | Pull US Prescribing Information sections from DailyMed — indications, dosing, warnings, contraindications, and more. Parsed from FDA structured product labels. |
+| `get_smpc` | Retrieve UK Summary of Product Characteristics from the eMC — the UK equivalent of US prescribing information, with numbered SmPC sections. |
+| `compare_labels` | Side-by-side comparison of US (USPI) and UK (SmPC) labelling for the same drug. Spot regulatory differences in indications, warnings, and dosing. |
+| `search_by_indication` | Find drugs approved for a medical condition. Searches FDA labelling via OpenFDA, then cross-references UK availability on the eMC. |
+
+## Setup
+
+### Prerequisites
+
+- Node.js 18+
+- An MCP-compatible client (Claude Desktop, Cursor, etc.)
+
+### Install and build
+
+```bash
+git clone https://github.com/nickjlamb/pubcrawl.git
+cd pubcrawl
+npm install
+npm run build
+```
+
+### Configure Claude Desktop
+
+Add to your `claude_desktop_config.json`:
+
+**macOS:** `~/Library/Application Support/Claude/claude_desktop_config.json`
+**Windows:** `%APPDATA%\Claude\claude_desktop_config.json`
+
+```json
+{
+  "mcpServers": {
+    "pubcrawl": {
+      "command": "node",
+      "args": ["/path/to/pubcrawl/dist/index.js"]
+    }
+  }
+}
+```
+
+Restart Claude Desktop. PubCrawl will appear under **+ → Connectors**.
+
+### NCBI API key (optional)
+
+Without an API key, requests are rate-limited to 3/second. With one, you get 10/second.
+
+1. Create a free NCBI account at https://www.ncbi.nlm.nih.gov/account/
+2. Go to Account Settings → API Key Management
+3. Add the key to your config:
+
+```json
+{
+  "mcpServers": {
+    "pubcrawl": {
+      "command": "node",
+      "args": ["/path/to/pubcrawl/dist/index.js"],
+      "env": {
+        "NCBI_API_KEY": "your_key_here"
+      }
+    }
+  }
+}
+```
+
+## Example prompts
+
+Once connected, just ask naturally:
+
+- "Search PubMed for recent clinical trials on semaglutide"
+- "Get the abstract for PMID 38127654"
+- "Find papers related to this one and format citations in APA"
+- "What are the trending papers on CRISPR gene therapy this month?"
+- "Get the full text of that paper from PMC"
+- "Get the FDA prescribing information for metformin — just the indications and warnings"
+- "Pull the UK SmPC for atorvastatin"
+- "Compare US and UK labelling for lisinopril"
+- "What drugs are approved for type 2 diabetes?"
+
+## Development
+
+```bash
+npm run dev    # TypeScript watch mode
+npm run build  # Compile to dist/
+npm start      # Run the server
+```
+
+## License
+
+MIT

package/dist/index.d.ts

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+#!/usr/bin/env node
+import "dotenv/config";
+//# sourceMappingURL=index.d.ts.map

package/dist/index.d.ts.map

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+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../src/index.ts"],"names":[],"mappings":";AACA,OAAO,eAAe,CAAC"}

package/dist/index.js

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+#!/usr/bin/env node
+import "dotenv/config";
+import { McpServer } from "@modelcontextprotocol/sdk/server/mcp.js";
+import { StdioServerTransport } from "@modelcontextprotocol/sdk/server/stdio.js";
+import { setApiKey } from "./lib/ncbi.js";
+import { registerSearchTool } from "./tools/search.js";
+import { registerAbstractTool } from "./tools/abstract.js";
+import { registerFullTextTool } from "./tools/fulltext.js";
+import { registerRelatedTool } from "./tools/related.js";
+import { registerCiteTool } from "./tools/cite.js";
+import { registerTrendingTool } from "./tools/trending.js";
+import { registerUspiTool } from "./tools/uspi.js";
+import { registerSmpcTool } from "./tools/smpc.js";
+import { registerCompareLabelsTool } from "./tools/compare-labels.js";
+import { registerSearchIndicationTool } from "./tools/search-indication.js";
+const server = new McpServer({
+    name: "pubcrawl",
+    version: "2.0.0",
+});
+// Configure NCBI API key if available (10 req/s vs 3 req/s)
+if (process.env.NCBI_API_KEY) {
+    setApiKey(process.env.NCBI_API_KEY);
+}
+// Register all tools
+registerSearchTool(server);
+registerAbstractTool(server);
+registerFullTextTool(server);
+registerRelatedTool(server);
+registerCiteTool(server);
+registerTrendingTool(server);
+registerUspiTool(server);
+registerSmpcTool(server);
+registerCompareLabelsTool(server);
+registerSearchIndicationTool(server);
+// Start server
+async function main() {
+    const transport = new StdioServerTransport();
+    await server.connect(transport);
+    console.error("PubCrawl MCP server running on stdio");
+}
+main().catch((error) => {
+    console.error("Fatal error:", error);
+    process.exit(1);
+});
+//# sourceMappingURL=index.js.map

package/dist/index.js.map

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+{"version":3,"file":"index.js","sourceRoot":"","sources":["../src/index.ts"],"names":[],"mappings":";AACA,OAAO,eAAe,CAAC;AACvB,OAAO,EAAE,SAAS,EAAE,MAAM,yCAAyC,CAAC;AACpE,OAAO,EAAE,oBAAoB,EAAE,MAAM,2CAA2C,CAAC;AACjF,OAAO,EAAE,SAAS,EAAE,MAAM,eAAe,CAAC;AAC1C,OAAO,EAAE,kBAAkB,EAAE,MAAM,mBAAmB,CAAC;AACvD,OAAO,EAAE,oBAAoB,EAAE,MAAM,qBAAqB,CAAC;AAC3D,OAAO,EAAE,oBAAoB,EAAE,MAAM,qBAAqB,CAAC;AAC3D,OAAO,EAAE,mBAAmB,EAAE,MAAM,oBAAoB,CAAC;AACzD,OAAO,EAAE,gBAAgB,EAAE,MAAM,iBAAiB,CAAC;AACnD,OAAO,EAAE,oBAAoB,EAAE,MAAM,qBAAqB,CAAC;AAC3D,OAAO,EAAE,gBAAgB,EAAE,MAAM,iBAAiB,CAAC;AACnD,OAAO,EAAE,gBAAgB,EAAE,MAAM,iBAAiB,CAAC;AACnD,OAAO,EAAE,yBAAyB,EAAE,MAAM,2BAA2B,CAAC;AACtE,OAAO,EAAE,4BAA4B,EAAE,MAAM,8BAA8B,CAAC;AAE5E,MAAM,MAAM,GAAG,IAAI,SAAS,CAAC;IAC3B,IAAI,EAAE,UAAU;IAChB,OAAO,EAAE,OAAO;CACjB,CAAC,CAAC;AAEH,4DAA4D;AAC5D,IAAI,OAAO,CAAC,GAAG,CAAC,YAAY,EAAE,CAAC;IAC7B,SAAS,CAAC,OAAO,CAAC,GAAG,CAAC,YAAY,CAAC,CAAC;AACtC,CAAC;AAED,qBAAqB;AACrB,kBAAkB,CAAC,MAAM,CAAC,CAAC;AAC3B,oBAAoB,CAAC,MAAM,CAAC,CAAC;AAC7B,oBAAoB,CAAC,MAAM,CAAC,CAAC;AAC7B,mBAAmB,CAAC,MAAM,CAAC,CAAC;AAC5B,gBAAgB,CAAC,MAAM,CAAC,CAAC;AACzB,oBAAoB,CAAC,MAAM,CAAC,CAAC;AAC7B,gBAAgB,CAAC,MAAM,CAAC,CAAC;AACzB,gBAAgB,CAAC,MAAM,CAAC,CAAC;AACzB,yBAAyB,CAAC,MAAM,CAAC,CAAC;AAClC,4BAA4B,CAAC,MAAM,CAAC,CAAC;AAErC,eAAe;AACf,KAAK,UAAU,IAAI;IACjB,MAAM,SAAS,GAAG,IAAI,oBAAoB,EAAE,CAAC;IAC7C,MAAM,MAAM,CAAC,OAAO,CAAC,SAAS,CAAC,CAAC;IAChC,OAAO,CAAC,KAAK,CAAC,sCAAsC,CAAC,CAAC;AACxD,CAAC;AAED,IAAI,EAAE,CAAC,KAAK,CAAC,CAAC,KAAK,EAAE,EAAE;IACrB,OAAO,CAAC,KAAK,CAAC,cAAc,EAAE,KAAK,CAAC,CAAC;IACrC,OAAO,CAAC,IAAI,CAAC,CAAC,CAAC,CAAC;AAClB,CAAC,CAAC,CAAC"}

package/dist/lib/cache.d.ts

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+export declare const TTL: {
+    readonly SEARCH: number;
+    readonly ABSTRACT: number;
+    readonly FULLTEXT: number;
+    readonly RELATED: number;
+    readonly SUMMARY: number;
+    readonly LABEL: number;
+};
+export declare class LRUCache {
+    private cache;
+    private maxEntries;
+    constructor(maxEntries?: number);
+    get<T>(key: string): T | undefined;
+    set<T>(key: string, value: T, ttl: number): void;
+    clear(): void;
+    get size(): number;
+}
+export declare const cache: LRUCache;
+//# sourceMappingURL=cache.d.ts.map

package/dist/lib/cache.d.ts.map

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+{"version":3,"file":"cache.d.ts","sourceRoot":"","sources":["../../src/lib/cache.ts"],"names":[],"mappings":"AAMA,eAAO,MAAM,GAAG;;;;;;;CAON,CAAC;AAEX,qBAAa,QAAQ;IACnB,OAAO,CAAC,KAAK,CAA0C;IACvD,OAAO,CAAC,UAAU,CAAS;gBAEf,UAAU,SAAsB;IAI5C,GAAG,CAAC,CAAC,EAAE,GAAG,EAAE,MAAM,GAAG,CAAC,GAAG,SAAS;IAelC,GAAG,CAAC,CAAC,EAAE,GAAG,EAAE,MAAM,EAAE,KAAK,EAAE,CAAC,EAAE,GAAG,EAAE,MAAM,GAAG,IAAI;IAgBhD,KAAK,IAAI,IAAI;IAIb,IAAI,IAAI,IAAI,MAAM,CAEjB;CACF;AAED,eAAO,MAAM,KAAK,UAAiB,CAAC"}

package/dist/lib/cache.js

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+const DEFAULT_MAX_ENTRIES = 500;
+const ONE_HOUR_MS = 60 * 60 * 1000;
+const ONE_DAY_MS = 24 * 60 * 60 * 1000;
+export const TTL = {
+    SEARCH: ONE_HOUR_MS,
+    ABSTRACT: ONE_DAY_MS,
+    FULLTEXT: ONE_DAY_MS,
+    RELATED: ONE_HOUR_MS,
+    SUMMARY: ONE_HOUR_MS,
+    LABEL: ONE_DAY_MS,
+};
+export class LRUCache {
+    cache = new Map();
+    maxEntries;
+    constructor(maxEntries = DEFAULT_MAX_ENTRIES) {
+        this.maxEntries = maxEntries;
+    }
+    get(key) {
+        const entry = this.cache.get(key);
+        if (!entry)
+            return undefined;
+        if (Date.now() - entry.timestamp > entry.ttl) {
+            this.cache.delete(key);
+            return undefined;
+        }
+        // Move to end (most recently used)
+        this.cache.delete(key);
+        this.cache.set(key, entry);
+        return entry.value;
+    }
+    set(key, value, ttl) {
+        if (this.cache.has(key)) {
+            this.cache.delete(key);
+        }
+        if (this.cache.size >= this.maxEntries) {
+            // Evict least recently used (first entry)
+            const firstKey = this.cache.keys().next().value;
+            if (firstKey !== undefined) {
+                this.cache.delete(firstKey);
+            }
+        }
+        this.cache.set(key, { value, timestamp: Date.now(), ttl });
+    }
+    clear() {
+        this.cache.clear();
+    }
+    get size() {
+        return this.cache.size;
+    }
+}
+export const cache = new LRUCache();
+//# sourceMappingURL=cache.js.map

package/dist/lib/cache.js.map

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+{"version":3,"file":"cache.js","sourceRoot":"","sources":["../../src/lib/cache.ts"],"names":[],"mappings":"AAEA,MAAM,mBAAmB,GAAG,GAAG,CAAC;AAChC,MAAM,WAAW,GAAG,EAAE,GAAG,EAAE,GAAG,IAAI,CAAC;AACnC,MAAM,UAAU,GAAG,EAAE,GAAG,EAAE,GAAG,EAAE,GAAG,IAAI,CAAC;AAEvC,MAAM,CAAC,MAAM,GAAG,GAAG;IACjB,MAAM,EAAE,WAAW;IACnB,QAAQ,EAAE,UAAU;IACpB,QAAQ,EAAE,UAAU;IACpB,OAAO,EAAE,WAAW;IACpB,OAAO,EAAE,WAAW;IACpB,KAAK,EAAE,UAAU;CACT,CAAC;AAEX,MAAM,OAAO,QAAQ;IACX,KAAK,GAAG,IAAI,GAAG,EAA+B,CAAC;IAC/C,UAAU,CAAS;IAE3B,YAAY,UAAU,GAAG,mBAAmB;QAC1C,IAAI,CAAC,UAAU,GAAG,UAAU,CAAC;IAC/B,CAAC;IAED,GAAG,CAAI,GAAW;QAChB,MAAM,KAAK,GAAG,IAAI,CAAC,KAAK,CAAC,GAAG,CAAC,GAAG,CAAC,CAAC;QAClC,IAAI,CAAC,KAAK;YAAE,OAAO,SAAS,CAAC;QAE7B,IAAI,IAAI,CAAC,GAAG,EAAE,GAAG,KAAK,CAAC,SAAS,GAAG,KAAK,CAAC,GAAG,EAAE,CAAC;YAC7C,IAAI,CAAC,KAAK,CAAC,MAAM,CAAC,GAAG,CAAC,CAAC;YACvB,OAAO,SAAS,CAAC;QACnB,CAAC;QAED,mCAAmC;QACnC,IAAI,CAAC,KAAK,CAAC,MAAM,CAAC,GAAG,CAAC,CAAC;QACvB,IAAI,CAAC,KAAK,CAAC,GAAG,CAAC,GAAG,EAAE,KAAK,CAAC,CAAC;QAC3B,OAAO,KAAK,CAAC,KAAU,CAAC;IAC1B,CAAC;IAED,GAAG,CAAI,GAAW,EAAE,KAAQ,EAAE,GAAW;QACvC,IAAI,IAAI,CAAC,KAAK,CAAC,GAAG,CAAC,GAAG,CAAC,EAAE,CAAC;YACxB,IAAI,CAAC,KAAK,CAAC,MAAM,CAAC,GAAG,CAAC,CAAC;QACzB,CAAC;QAED,IAAI,IAAI,CAAC,KAAK,CAAC,IAAI,IAAI,IAAI,CAAC,UAAU,EAAE,CAAC;YACvC,0CAA0C;YAC1C,MAAM,QAAQ,GAAG,IAAI,CAAC,KAAK,CAAC,IAAI,EAAE,CAAC,IAAI,EAAE,CAAC,KAAK,CAAC;YAChD,IAAI,QAAQ,KAAK,SAAS,EAAE,CAAC;gBAC3B,IAAI,CAAC,KAAK,CAAC,MAAM,CAAC,QAAQ,CAAC,CAAC;YAC9B,CAAC;QACH,CAAC;QAED,IAAI,CAAC,KAAK,CAAC,GAAG,CAAC,GAAG,EAAE,EAAE,KAAK,EAAE,SAAS,EAAE,IAAI,CAAC,GAAG,EAAE,EAAE,GAAG,EAAE,CAAC,CAAC;IAC7D,CAAC;IAED,KAAK;QACH,IAAI,CAAC,KAAK,CAAC,KAAK,EAAE,CAAC;IACrB,CAAC;IAED,IAAI,IAAI;QACN,OAAO,IAAI,CAAC,KAAK,CAAC,IAAI,CAAC;IACzB,CAAC;CACF;AAED,MAAM,CAAC,MAAM,KAAK,GAAG,IAAI,QAAQ,EAAE,CAAC"}

package/dist/lib/dailymed.d.ts

@@ -0,0 +1,9 @@
+export interface DailyMedSearchResult {
+    setid: string;
+    title: string;
+    published_date: string;
+    spl_version: string;
+}
+export declare function searchDrugLabels(drugName: string): Promise<DailyMedSearchResult[]>;
+export declare function fetchSplXml(setid: string): Promise<string>;
+//# sourceMappingURL=dailymed.d.ts.map

package/dist/lib/dailymed.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"dailymed.d.ts","sourceRoot":"","sources":["../../src/lib/dailymed.ts"],"names":[],"mappings":"AAgCA,MAAM,WAAW,oBAAoB;IACnC,KAAK,EAAE,MAAM,CAAC;IACd,KAAK,EAAE,MAAM,CAAC;IACd,cAAc,EAAE,MAAM,CAAC;IACvB,WAAW,EAAE,MAAM,CAAC;CACrB;AAED,wBAAsB,gBAAgB,CAAC,QAAQ,EAAE,MAAM,GAAG,OAAO,CAAC,oBAAoB,EAAE,CAAC,CAyBxF;AAED,wBAAsB,WAAW,CAAC,KAAK,EAAE,MAAM,GAAG,OAAO,CAAC,MAAM,CAAC,CAWhE"}

package/dist/lib/dailymed.js

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+import { cache, TTL } from "./cache.js";
+const BASE_URL = "https://dailymed.nlm.nih.gov/dailymed/services/v2";
+const REQUEST_DELAY_MS = 200;
+const TIMEOUT_MS = 20000;
+let lastRequestTime = 0;
+async function rateLimitedFetch(url) {
+    const now = Date.now();
+    const elapsed = now - lastRequestTime;
+    if (elapsed < REQUEST_DELAY_MS) {
+        await new Promise((resolve) => setTimeout(resolve, REQUEST_DELAY_MS - elapsed));
+    }
+    lastRequestTime = Date.now();
+    const controller = new AbortController();
+    const timeout = setTimeout(() => controller.abort(), TIMEOUT_MS);
+    try {
+        const response = await fetch(url, { signal: controller.signal });
+        if (!response.ok) {
+            throw new Error(`DailyMed API error: ${response.status} ${response.statusText}`);
+        }
+        return response;
+    }
+    finally {
+        clearTimeout(timeout);
+    }
+}
+export async function searchDrugLabels(drugName) {
+    const cacheKey = `dailymed:search:${drugName.toLowerCase()}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const params = new URLSearchParams({
+        drug_name: drugName,
+        pagesize: "10",
+    });
+    const url = `${BASE_URL}/spls.json?${params}`;
+    const response = await rateLimitedFetch(url);
+    const data = await response.json();
+    const results = (data.data ?? []).map((item) => ({
+        setid: String(item.setid ?? ""),
+        title: String(item.title ?? ""),
+        published_date: String(item.published_date ?? ""),
+        spl_version: String(item.spl_version ?? ""),
+    }));
+    cache.set(cacheKey, results, TTL.SEARCH);
+    return results;
+}
+export async function fetchSplXml(setid) {
+    const cacheKey = `dailymed:spl:${setid}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const url = `${BASE_URL}/spls/${setid}.xml`;
+    const response = await rateLimitedFetch(url);
+    const text = await response.text();
+    cache.set(cacheKey, text, TTL.LABEL);
+    return text;
+}
+//# sourceMappingURL=dailymed.js.map

package/dist/lib/dailymed.js.map

@@ -0,0 +1 @@
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package/dist/lib/emc.d.ts

@@ -0,0 +1,13 @@
+export interface EmcSearchResult {
+    product_id: string;
+    name: string;
+    company: string;
+}
+export declare function searchEmc(drugName: string): Promise<EmcSearchResult[]>;
+export declare function fetchSmpcHtml(productId: string): Promise<string>;
+export declare function parseSmpcSections(html: string, requestedSections?: string[]): Array<{
+    code: string;
+    title: string;
+    content: string;
+}>;
+//# sourceMappingURL=emc.d.ts.map

package/dist/lib/emc.d.ts.map

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package/dist/lib/emc.js

@@ -0,0 +1,215 @@
+import * as cheerio from "cheerio";
+import { cache, TTL } from "./cache.js";
+const BASE_URL = "https://www.medicines.org.uk";
+const REQUEST_DELAY_MS = 1000;
+const TIMEOUT_MS = 20000;
+const USER_AGENT = "PubCrawl/2.0 (pharmatools.ai; nick@pharmatools.ai)";
+let lastRequestTime = 0;
+async function rateLimitedFetch(url) {
+    const now = Date.now();
+    const elapsed = now - lastRequestTime;
+    if (elapsed < REQUEST_DELAY_MS) {
+        await new Promise((resolve) => setTimeout(resolve, REQUEST_DELAY_MS - elapsed));
+    }
+    lastRequestTime = Date.now();
+    const controller = new AbortController();
+    const timeout = setTimeout(() => controller.abort(), TIMEOUT_MS);
+    try {
+        const response = await fetch(url, {
+            signal: controller.signal,
+            headers: { "User-Agent": USER_AGENT },
+        });
+        if (!response.ok) {
+            throw new Error(`eMC error: ${response.status} ${response.statusText}`);
+        }
+        return response;
+    }
+    finally {
+        clearTimeout(timeout);
+    }
+}
+export async function searchEmc(drugName) {
+    const cacheKey = `emc:search:${drugName.toLowerCase()}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const params = new URLSearchParams({ q: drugName });
+    const url = `${BASE_URL}/emc/search?${params}`;
+    const response = await rateLimitedFetch(url);
+    const html = await response.text();
+    const $ = cheerio.load(html);
+    const results = [];
+    // Parse search results — look for SmPC links (href contains /smpc)
+    $("a[href*='/emc/product/']").each((_, el) => {
+        const href = $(el).attr("href") ?? "";
+        const smpcMatch = href.match(/\/emc\/product\/(\d+)\/smpc/);
+        if (!smpcMatch)
+            return;
+        const product_id = smpcMatch[1];
+        const name = $(el).text().trim();
+        // Skip generic link text like "Health Professionals (SmPC)"
+        if (!name || name.toLowerCase().includes("health professional"))
+            return;
+        // Avoid duplicates
+        if (results.some((r) => r.product_id === product_id))
+            return;
+        // Try to find company from nearby text
+        const parent = $(el).closest("li, tr, div, article");
+        const company = parent.find(".company, .manufacturer").text().trim();
+        results.push({ product_id, name, company });
+    });
+    cache.set(cacheKey, results, TTL.SEARCH);
+    return results;
+}
+export async function fetchSmpcHtml(productId) {
+    const cacheKey = `emc:smpc:${productId}`;
+    const cached = cache.get(cacheKey);
+    if (cached)
+        return cached;
+    const url = `${BASE_URL}/emc/product/${productId}/smpc`;
+    const response = await rateLimitedFetch(url);
+    const html = await response.text();
+    cache.set(cacheKey, html, TTL.LABEL);
+    return html;
+}
+// SmPC standard section numbering
+const SMPC_SECTION_NAMES = {
+    "4.1": "Therapeutic indications",
+    "4.2": "Posology and method of administration",
+    "4.3": "Contraindications",
+    "4.4": "Special warnings and precautions for use",
+    "4.5": "Interaction with other medicinal products",
+    "4.6": "Fertility, pregnancy and lactation",
+    "4.7": "Effects on ability to drive and use machines",
+    "4.8": "Undesirable effects",
+    "4.9": "Overdose",
+    "5.1": "Pharmacodynamic properties",
+    "5.2": "Pharmacokinetic properties",
+    "5.3": "Preclinical safety data",
+    "6.1": "List of excipients",
+    "6.2": "Incompatibilities",
+    "6.3": "Shelf life",
+    "6.4": "Special precautions for storage",
+    "6.5": "Nature and contents of container",
+    "6.6": "Special precautions for disposal",
+};
+function htmlToText(html) {
+    const $ = cheerio.load(html);
+    // Replace <br> with newlines
+    $("br").replaceWith("\n");
+    // Replace <li> with bullet points
+    $("li").each((_, el) => {
+        $(el).prepend("- ");
+        $(el).append("\n");
+    });
+    // Add newlines after block elements
+    $("p, div, tr, h1, h2, h3, h4, h5, h6").each((_, el) => {
+        $(el).append("\n");
+    });
+    return $.text().replace(/\n{3,}/g, "\n\n").trim();
+}
+export function parseSmpcSections(html, requestedSections) {
+    const $ = cheerio.load(html);
+    const results = [];
+    const sectionElements = [];
+    // Strategy 1: Look for elements with IDs or classes containing section numbers
+    $("[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4").each((_, el) => {
+        const text = $(el).text().trim();
+        const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+        if (match) {
+            sectionElements.push({
+                code: match[1],
+                title: match[2].trim(),
+                element: $(el),
+            });
+        }
+    });
+    // Strategy 2: If strategy 1 found nothing, scan all text nodes for section headers
+    if (sectionElements.length === 0) {
+        $("*").each((_, el) => {
+            const $el = $(el);
+            if ($el.children().length > 0 && !$el.is("a, span, strong, em, b, i"))
+                return;
+            const text = $el.text().trim();
+            const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+            if (match && SMPC_SECTION_NAMES[match[1]]) {
+                sectionElements.push({
+                    code: match[1],
+                    title: match[2].trim(),
+                    element: $el,
+                });
+            }
+        });
+    }
+    // Extract content between consecutive headings
+    for (let i = 0; i < sectionElements.length; i++) {
+        const current = sectionElements[i];
+        const next = sectionElements[i + 1];
+        // Collect all sibling content between this heading and the next
+        let content = "";
+        let node = current.element.next();
+        while (node.length > 0) {
+            if (next && node.is(next.element))
+                break;
+            const nodeHtml = $.html(node);
+            if (nodeHtml) {
+                content += htmlToText(nodeHtml) + "\n";
+            }
+            node = node.next();
+        }
+        // If no content from sibling traversal, try parent's content
+        if (!content.trim()) {
+            const parent = current.element.parent();
+            const parentHtml = $.html(parent);
+            if (parentHtml) {
+                const parentText = htmlToText(parentHtml);
+                // Remove the heading text itself
+                const headingText = current.element.text().trim();
+                content = parentText.replace(headingText, "").trim();
+            }
+        }
+        results.push({
+            code: current.code,
+            title: current.title,
+            content: content.trim(),
+        });
+    }
+    // Filter by requested sections if specified
+    if (requestedSections && requestedSections.length > 0) {
+        const filtered = results.filter((s) => {
+            return requestedSections.some((req) => {
+                const lower = req.toLowerCase().trim();
+                // Match by section number (e.g., "4.1")
+                if (s.code === lower || s.code === req)
+                    return true;
+                // Match by name substring
+                if (s.title.toLowerCase().includes(lower))
+                    return true;
+                if (lower.includes("indication"))
+                    return s.code === "4.1";
+                if (lower.includes("dosage") || lower.includes("dosing") || lower.includes("posology"))
+                    return s.code === "4.2";
+                if (lower.includes("contraindication"))
+                    return s.code === "4.3";
+                if (lower.includes("warning") || lower.includes("precaution"))
+                    return s.code === "4.4";
+                if (lower.includes("interaction"))
+                    return s.code === "4.5";
+                if (lower.includes("pregnancy") || lower.includes("fertility"))
+                    return s.code === "4.6";
+                if (lower.includes("adverse") || lower.includes("undesirable") || lower.includes("side effect"))
+                    return s.code === "4.8";
+                if (lower.includes("overdose") || lower.includes("overdosage"))
+                    return s.code === "4.9";
+                if (lower.includes("pharmacodynamic"))
+                    return s.code === "5.1";
+                if (lower.includes("pharmacokinetic"))
+                    return s.code === "5.2";
+                return false;
+            });
+        });
+        return filtered;
+    }
+    return results;
+}
+//# sourceMappingURL=emc.js.map

package/dist/lib/emc.js.map

@@ -0,0 +1 @@
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package/dist/lib/label-mapping.d.ts

@@ -0,0 +1,8 @@
+export interface SectionMapping {
+    topic: string;
+    us_loinc: string;
+    uk_code: string;
+}
+export declare const SECTION_MAP: SectionMapping[];
+export declare function filterSectionMap(requestedTopics?: string[]): SectionMapping[];
+//# sourceMappingURL=label-mapping.d.ts.map

package/dist/lib/label-mapping.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"label-mapping.d.ts","sourceRoot":"","sources":["../../src/lib/label-mapping.ts"],"names":[],"mappings":"AAAA,MAAM,WAAW,cAAc;IAC7B,KAAK,EAAE,MAAM,CAAC;IACd,QAAQ,EAAE,MAAM,CAAC;IACjB,OAAO,EAAE,MAAM,CAAC;CACjB;AAED,eAAO,MAAM,WAAW,EAAE,cAAc,EAUvC,CAAC;AAEF,wBAAgB,gBAAgB,CAAC,eAAe,CAAC,EAAE,MAAM,EAAE,GAAG,cAAc,EAAE,CAc7E"}

package/dist/lib/label-mapping.js

@@ -0,0 +1,23 @@
+export const SECTION_MAP = [
+    { topic: "Indications", us_loinc: "34067-9", uk_code: "4.1" },
+    { topic: "Dosing", us_loinc: "34068-7", uk_code: "4.2" },
+    { topic: "Contraindications", us_loinc: "34070-3", uk_code: "4.3" },
+    { topic: "Warnings", us_loinc: "43685-7", uk_code: "4.4" },
+    { topic: "Drug Interactions", us_loinc: "34073-7", uk_code: "4.5" },
+    { topic: "Pregnancy", us_loinc: "42228-7", uk_code: "4.6" },
+    { topic: "Adverse Reactions", us_loinc: "34084-4", uk_code: "4.8" },
+    { topic: "Overdosage", us_loinc: "34088-5", uk_code: "4.9" },
+    { topic: "Clinical Pharmacology", us_loinc: "34090-1", uk_code: "5.1" },
+];
+export function filterSectionMap(requestedTopics) {
+    if (!requestedTopics || requestedTopics.length === 0)
+        return SECTION_MAP;
+    return SECTION_MAP.filter((mapping) => requestedTopics.some((req) => {
+        const lower = req.toLowerCase().trim();
+        return (mapping.topic.toLowerCase().includes(lower) ||
+            lower.includes(mapping.topic.toLowerCase()) ||
+            mapping.us_loinc === req ||
+            mapping.uk_code === req);
+    }));
+}
+//# sourceMappingURL=label-mapping.js.map

package/dist/lib/label-mapping.js.map

@@ -0,0 +1 @@
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