@pharmatools/drug-data 0.2.0 → 0.2.1

package/dist/index.cjs

@@ -168,9 +168,17 @@ async function resolveViaRxNorm(name) {
     brandNames = single.length ? single : fallback;
   }
   let genericName = null;
-  if (minNames.length) genericName = titleCase(minNames[0]);
-  else if (inNames.length === 1) genericName = titleCase(inNames[0]);
-  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(" / "));
+  if (tty === "IN" || tty === "MIN") {
+    genericName = titleCase(canonicalName);
+  } else if (minNames.length) {
+    genericName = titleCase(minNames[0]);
+  } else if (inNames.length === 1) {
+    genericName = titleCase(inNames[0]);
+  } else if (inNames.length > 1) {
+    genericName = titleCase(uniq(inNames).join(" / "));
+  } else {
+    genericName = titleCase(canonicalName);
+  }
   const classRxcui = !isBrand ? rxcui : (() => {
     const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x) => x.tty === "IN");
     return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;

package/dist/index.cjs.map

@@ -1 +1 @@
-{"version":3,"sources":["../src/index.ts","../src/fetch.ts","../src/names.ts","../src/labels.ts","../src/compare.ts"],"sourcesContent":["// @pharmatools/drug-data — public surface\n\nexport { resolveName } from \"./names.js\";\n// 5-field convenience view (Pharmonym)\nexport { getUspi, getSmpc, getLabels } from \"./labels.js\";\n// General all-section access (PubCrawl)\nexport { getUsLabel, getUkSmpc } from \"./labels.js\";\nexport { compareLabels, SECTION_MAP } from \"./compare.js\";\nexport { cleanSection, formatFdaDate } from \"./fetch.js\";\nexport type {\n  Region,\n  RegionLabel,\n  LabelResult,\n  LabelSection,\n  UsLabelResult,\n  UkSmpcResult,\n  ResolveResult,\n  LabelComparison,\n  CompareResult,\n} from \"./types.js\";\n","/**\n * Shared HTTP + text helpers. Uses the runtime's global `fetch` (Node >=18),\n * so the package has no node-fetch dependency.\n */\n\nconst DEFAULT_TIMEOUT_MS = 12000;\nconst MAX_FIELD_CHARS = 1400;\n\nexport const USER_AGENT = \"drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)\";\n\nexport async function timedFetch(\n  url: string,\n  opts: RequestInit = {},\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<Response> {\n  const controller = new AbortController();\n  const timer = setTimeout(() => controller.abort(), timeoutMs);\n  try {\n    return await fetch(url, {\n      ...opts,\n      signal: controller.signal,\n      headers: { \"User-Agent\": USER_AGENT, ...((opts.headers as Record<string, string>) || {}) },\n    });\n  } finally {\n    clearTimeout(timer);\n  }\n}\n\nexport async function getJson<T = unknown>(\n  url: string,\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<T | null> {\n  try {\n    const res = await timedFetch(url, {}, timeoutMs);\n    if (!res.ok) return null;\n    return (await res.json()) as T;\n  } catch {\n    return null;\n  }\n}\n\n/**\n * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS\n * heading, collapse whitespace, and truncate on a sentence boundary.\n */\nexport function cleanSection(value: unknown, maxChars = MAX_FIELD_CHARS): string {\n  if (!value) return \"\";\n  let text = Array.isArray(value) ? value.join(\"\\n\\n\") : String(value);\n\n  text = text\n    .replace(/\\r/g, \"\")\n    .replace(/[ \\t]+/g, \" \")\n    .replace(/\\n{3,}/g, \"\\n\\n\")\n    .trim();\n\n  // Drop a leading section header line like \"5 WARNINGS AND PRECAUTIONS\"\n  text = text.replace(/^\\s*\\d+(\\.\\d+)*\\s+[A-Z][A-Z \\-/,&]+\\n+/, \"\").trim();\n\n  if (text.length > maxChars) {\n    const slice = text.slice(0, maxChars);\n    const lastStop = Math.max(slice.lastIndexOf(\". \"), slice.lastIndexOf(\"\\n\"));\n    text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + \" …\";\n  }\n  return text;\n}\n\nexport function formatFdaDate(yyyymmdd?: string): string {\n  if (!yyyymmdd || !/^\\d{8}$/.test(yyyymmdd)) return \"\";\n  const d = new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);\n  if (isNaN(d.getTime())) return \"\";\n  return d.toLocaleDateString(\"en-US\", { year: \"numeric\", month: \"short\", day: \"numeric\" });\n}\n\nexport function titleCase(s: string): string {\n  return String(s || \"\").replace(/\\w\\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());\n}\n\nexport function uniq<T>(arr: T[]): T[] {\n  return [...new Set(arr.filter(Boolean))];\n}\n","/**\n * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA\n * fallback. No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n  const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n  const id = exact?.idGroup?.rxnormId?.[0];\n  if (id) return id;\n\n  const approx = await getJson<any>(\n    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n    TIMEOUT_MS\n  );\n  const cand = approx?.approximateGroup?.candidate?.[0];\n  return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === tty);\n  if (!g || !g.conceptProperties) return [];\n  return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n  const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n  const groups = data?.relatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === \"SBDF\");\n  if (!g || !g.conceptProperties) return [];\n  const brands: string[] = [];\n  for (const c of g.conceptProperties) {\n    const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n    if (!m) continue;\n    const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n    if (prefix.includes(\"/\")) continue; // combination product — skip\n    brands.push(m[1].trim());\n  }\n  return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n  rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n  const data = await getJson<any>(\n    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n    TIMEOUT_MS\n  );\n  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n  const byType = (t: string): string | null => {\n    const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n    return hit ? hit.rxclassMinConceptItem.className : null;\n  };\n  // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n  const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n  const uses = uniq<string>(\n    items\n      .filter((i: any) => i.rela === \"may_treat\")\n      .map((i: any) => i.rxclassMinConceptItem.className as string)\n  ).slice(0, 6);\n\n  return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n  const rxcui = await findRxcui(name);\n  if (!rxcui) return null;\n\n  const [props, allRelated] = await Promise.all([\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n  ]);\n\n  const tty: string | undefined = props?.properties?.tty;\n  const canonicalName: string = props?.properties?.name ?? name;\n  if (!tty) return null;\n\n  const inNames = collectNames(allRelated, \"IN\");\n  const minNames = collectNames(allRelated, \"MIN\");\n\n  const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n  const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n  // For a generic, list only brands where it is the sole active ingredient.\n  let brandNames: string[] | null = null;\n  if (!isBrand) {\n    const single = await getSingleIngredientBrands(rxcui);\n    const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n    brandNames = single.length ? single : fallback;\n  }\n\n  // Generic display name: prefer the canonical combo string, else single, else joined.\n  let genericName: string | null = null;\n  if (minNames.length) genericName = titleCase(minNames[0]);\n  else if (inNames.length === 1) genericName = titleCase(inNames[0]);\n  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(\" / \"));\n\n  // Class + indications from the ingredient rxcui where possible.\n  const classRxcui = !isBrand\n    ? rxcui\n    : (() => {\n        const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n        return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n      })();\n  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n  return {\n    inputType,\n    inputName: titleCase(canonicalName),\n    genericName,\n    brandNames,\n    drugClass,\n    uses,\n    rxcui,\n    source: \"RxNorm (NLM)\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n  const q = name.replace(/\"/g, \"\");\n  const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n  const data = await getJson<any>(url, TIMEOUT_MS);\n  const fda = data?.results?.[0]?.openfda;\n  if (!fda) return null;\n\n  const brand = (fda.brand_name ?? [])[0] ?? \"\";\n  const generic = (fda.generic_name ?? [])[0] ?? \"\";\n  if (!brand && !generic) return null;\n\n  const isBrand = brand.toLowerCase() === name.toLowerCase();\n  return {\n    inputType: isBrand ? \"brand\" : \"generic\",\n    inputName: titleCase(name),\n    genericName: generic ? titleCase(generic) : null,\n    brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n    uses: [],\n    rxcui: null,\n    source: \"openFDA\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n  if (!name || !name.trim()) return null;\n  const clean = name.trim();\n  const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n  if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n    return viaRx;\n  }\n  return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n *   - US:    FDA label via the openFDA API  -> DailyMed citation\n *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Two layers:\n *   - getUsLabel / getUkSmpc  — general, all-section access (LabelSection[]),\n *     used by PubCrawl's get_uspi / get_smpc / compare_labels tools.\n *   - getUspi / getSmpc / getLabels — a 5-field convenience view (RegionLabel)\n *     used by Pharmonym. Built on the same fetch + parse internals.\n *\n * Every network call is best-effort: failures return null. Pure fetch + parse;\n * caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult, LabelSection, UsLabelResult, UkSmpcResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n  effective_time?: string;\n  boxed_warning?: string[];\n  indications_and_usage?: string[];\n  dosage_and_administration?: string[];\n  dosage_forms_and_strengths?: string[];\n  contraindications?: string[];\n  warnings_and_cautions?: string[];\n  warnings?: string[];\n  adverse_reactions?: string[];\n  drug_interactions?: string[];\n  use_in_specific_populations?: string[];\n  overdosage?: string[];\n  clinical_pharmacology?: string[];\n  description?: string[];\n  how_supplied?: string[];\n  openfda?: {\n    generic_name?: string[];\n    brand_name?: string[];\n    spl_set_id?: string[];\n  };\n}\ninterface OpenFdaResponse {\n  results?: OpenFdaLabel[];\n}\n\n// openFDA field -> { LOINC code, display title }. Order = label reading order.\nconst US_SECTION_MAP: Array<{ field: keyof OpenFdaLabel; code: string; title: string }> = [\n  { field: \"boxed_warning\", code: \"34066-1\", title: \"Boxed Warning\" },\n  { field: \"indications_and_usage\", code: \"34067-9\", title: \"Indications and Usage\" },\n  { field: \"dosage_and_administration\", code: \"34068-7\", title: \"Dosage and Administration\" },\n  { field: \"dosage_forms_and_strengths\", code: \"43678-2\", title: \"Dosage Forms and Strengths\" },\n  { field: \"contraindications\", code: \"34070-3\", title: \"Contraindications\" },\n  { field: \"warnings_and_cautions\", code: \"43685-7\", title: \"Warnings and Precautions\" },\n  { field: \"warnings\", code: \"34071-1\", title: \"Warnings\" },\n  { field: \"adverse_reactions\", code: \"34084-4\", title: \"Adverse Reactions\" },\n  { field: \"drug_interactions\", code: \"34073-7\", title: \"Drug Interactions\" },\n  { field: \"use_in_specific_populations\", code: \"42228-7\", title: \"Use in Specific Populations\" },\n  { field: \"overdosage\", code: \"34088-5\", title: \"Overdosage\" },\n  { field: \"clinical_pharmacology\", code: \"34090-1\", title: \"Clinical Pharmacology\" },\n  { field: \"description\", code: \"34089-3\", title: \"Description\" },\n  { field: \"how_supplied\", code: \"34069-5\", title: \"How Supplied\" },\n];\n\n/* --------------------------- US: openFDA --------------------------- */\n\nfunction score(r: OpenFdaLabel, q: string): number {\n  const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n  let s = 0;\n  if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n  if (g.includes(q.toLowerCase())) s += 1;\n  return s;\n}\n\n/** Fetch the most recent FDA label for a drug; prefers single-ingredient products. */\nasync function fetchOpenFdaBest(drug: string): Promise<OpenFdaLabel | null> {\n  if (!drug) return null;\n  const q = drug.trim().replace(/\"/g, \"\");\n  const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n  const data = await getJson<OpenFdaResponse>(url);\n  const results = data?.results ?? [];\n  if (results.length === 0) return null;\n  return results.slice().sort((a, b) => score(b, q) - score(a, q))[0];\n}\n\nfunction usMeta(r: OpenFdaLabel, fallbackName: string) {\n  const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n  const brand = r.openfda?.brand_name?.[0] ?? \"\";\n  const generic = r.openfda?.generic_name?.[0] ?? fallbackName;\n  return {\n    setId,\n    brand,\n    generic,\n    productName: brand ? `${brand} (${generic})` : generic,\n    dailymedUrl: setId\n      ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n      : \"https://dailymed.nlm.nih.gov/dailymed/\",\n  };\n}\n\nfunction matchesUsFilter(entry: { field: string; code: string; title: string }, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    return (\n      entry.code === req ||\n      entry.title.toLowerCase().includes(r) ||\n      String(entry.field).replace(/_/g, \" \").includes(r) ||\n      r.includes(entry.title.toLowerCase())\n    );\n  });\n}\n\n/**\n * General US label access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_uspi.\n */\nexport async function getUsLabel(drug: string, requested?: string[]): Promise<UsLabelResult | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const sections: LabelSection[] = [];\n  for (const entry of US_SECTION_MAP) {\n    if (requested?.length && !matchesUsFilter(entry, requested)) continue;\n    const content = cleanSection(r[entry.field]);\n    if (content) sections.push({ code: entry.code, title: entry.title, content });\n  }\n  if (sections.length === 0) return null;\n\n  return {\n    drugName: meta.productName,\n    setId: meta.setId,\n    publishedDate: formatFdaDate(r.effective_time),\n    sections,\n    dailymedUrl: meta.dailymedUrl,\n  };\n}\n\n/** 5-field convenience view of the US label (Pharmonym). */\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const dosage = cleanSection(r.dosage_and_administration);\n  const boxed = cleanSection(r.boxed_warning);\n  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n  const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n  const adverse = cleanSection(r.adverse_reactions);\n  const indications = cleanSection(r.indications_and_usage);\n  const contraindications = cleanSection(r.contraindications);\n\n  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n  return {\n    region: \"US\",\n    authority: \"FDA Prescribing Information\",\n    productName: meta.productName,\n    indications: indications || null,\n    dosage: dosage || null,\n    contraindications: contraindications || null,\n    warnings: warnings || null,\n    adverse: adverse || null,\n    updated: formatFdaDate(r.effective_time),\n    sourceUrl: meta.dailymedUrl,\n    sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n  };\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n  product_id: string;\n  name: string;\n}\n\nasync function searchEmcAll(drug: string): Promise<EmcMatch[]> {\n  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n  const res = await timedFetch(url);\n  if (!res.ok) return [];\n  const html = await res.text();\n  const $ = cheerio.load(html);\n  const out: EmcMatch[] = [];\n  $(\"a[href*='/emc/product/']\").each((_, el) => {\n    const href = $(el).attr(\"href\") || \"\";\n    const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n    if (!m) return;\n    const name = $(el).text().trim();\n    if (!name || name.toLowerCase().includes(\"health professional\")) return;\n    if (out.some((x) => x.product_id === m[1])) return;\n    out.push({ product_id: m[1], name });\n  });\n  return out;\n}\n\nasync function searchEmcBest(drug: string): Promise<EmcMatch | null> {\n  const matches = await searchEmcAll(drug);\n  if (matches.length === 0) return null;\n  const q = drug.toLowerCase();\n  matches.sort(\n    (a, b) =>\n      (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n  );\n  return matches[0];\n}\n\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n  \"4.1\": \"Therapeutic indications\",\n  \"4.2\": \"Posology and method of administration\",\n  \"4.3\": \"Contraindications\",\n  \"4.4\": \"Special warnings and precautions for use\",\n  \"4.5\": \"Interaction with other medicinal products\",\n  \"4.6\": \"Fertility, pregnancy and lactation\",\n  \"4.7\": \"Effects on ability to drive and use machines\",\n  \"4.8\": \"Undesirable effects\",\n  \"4.9\": \"Overdose\",\n  \"5.1\": \"Pharmacodynamic properties\",\n  \"5.2\": \"Pharmacokinetic properties\",\n  \"5.3\": \"Preclinical safety data\",\n  \"6.1\": \"List of excipients\",\n  \"6.2\": \"Incompatibilities\",\n  \"6.3\": \"Shelf life\",\n  \"6.4\": \"Special precautions for storage\",\n  \"6.5\": \"Nature and contents of container\",\n  \"6.6\": \"Special precautions for disposal\",\n};\n\nfunction htmlToText(html: string): string {\n  const $ = cheerio.load(html);\n  $(\"br\").replaceWith(\"\\n\");\n  $(\"li\").each((_, el) => {\n    $(el).prepend(\"- \");\n    $(el).append(\"\\n\");\n  });\n  $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n    $(el).append(\"\\n\");\n  });\n  return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\nfunction matchesSmpcFilter(code: string, title: string, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    if (code === req || code === r) return true;\n    if (title.toLowerCase().includes(r)) return true;\n    if (r.includes(\"indication\")) return code === \"4.1\";\n    if (r.includes(\"dosage\") || r.includes(\"dosing\") || r.includes(\"posology\")) return code === \"4.2\";\n    if (r.includes(\"contraindication\")) return code === \"4.3\";\n    if (r.includes(\"warning\") || r.includes(\"precaution\")) return code === \"4.4\";\n    if (r.includes(\"interaction\")) return code === \"4.5\";\n    if (r.includes(\"pregnancy\") || r.includes(\"fertility\")) return code === \"4.6\";\n    if (r.includes(\"adverse\") || r.includes(\"undesirable\") || r.includes(\"side effect\")) return code === \"4.8\";\n    if (r.includes(\"overdose\") || r.includes(\"overdosage\")) return code === \"4.9\";\n    if (r.includes(\"pharmacodynamic\")) return code === \"5.1\";\n    if (r.includes(\"pharmacokinetic\")) return code === \"5.2\";\n    return false;\n  });\n}\n\n/**\n * Parse SmPC sections from eMC HTML. Returns every detected numbered section as\n * LabelSection[] (or the requested subset). 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Powers PubCrawl's get_smpc.\n */\nexport async function getUkSmpc(drug: string, requested?: string[]): Promise<UkSmpcResult | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const sections = parseSmpcSections(await res.text(), requested);\n    if (sections.length === 0) return null;\n    return {\n      drugName: best.name,\n      productId: best.product_id,\n      sections,\n      url: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n    };\n  } catch {\n    return null;\n  }\n}\n\n/** 5-field convenience view of the UK/EU SmPC (Pharmonym). */\nexport async function getSmpc(drug: string): Promise<RegionLabel | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const all = parseSmpcSections(await res.text());\n    const pick = (code: string) => all.find((s) => s.code === code)?.content ?? null;\n\n    const indications = pick(\"4.1\");\n    const dosage = pick(\"4.2\");\n    const contraindications = pick(\"4.3\");\n    const warnings = pick(\"4.4\");\n    const adverse = pick(\"4.8\");\n    if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n    return {\n      region: \"UK/EU\",\n      authority: \"Summary of Product Characteristics (SmPC)\",\n      productName: best.name,\n      indications,\n      dosage,\n      contraindications,\n      warnings,\n      adverse,\n      updated: \"\",\n      sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n      sourceLabel: \"electronic medicines compendium (emc), UK\",\n    };\n  } catch {\n    return null;\n  }\n}\n\n/* --------------------------- public API ---------------------------- */\n\n/** Look up both 5-field labels for a drug. 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\"adverse\" },\n];\n\nexport async function compareLabels(drug: string): Promise<CompareResult> {\n  const { us, uk } = await getLabels(drug);\n\n  const comparisons: LabelComparison[] = SECTION_MAP.map(({ topic, field }) => ({\n    topic,\n    us: us ? us[field] : null,\n    uk: uk ? uk[field] : null,\n  })).filter((c) => c.us || c.uk);\n\n  return {\n    drug,\n    comparisons,\n    usSource: us?.sourceUrl ?? null,\n    ukSource: uk?.sourceUrl ?? null,\n  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Uses the runtime's global `fetch` (Node >=18),\n * so the package has no node-fetch dependency.\n */\n\nconst DEFAULT_TIMEOUT_MS = 12000;\nconst MAX_FIELD_CHARS = 1400;\n\nexport const USER_AGENT = \"drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)\";\n\nexport async function timedFetch(\n  url: string,\n  opts: RequestInit = {},\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<Response> {\n  const controller = new AbortController();\n  const timer = setTimeout(() => controller.abort(), timeoutMs);\n  try {\n    return await fetch(url, {\n      ...opts,\n      signal: controller.signal,\n      headers: { \"User-Agent\": USER_AGENT, ...((opts.headers as Record<string, string>) || {}) },\n    });\n  } finally {\n    clearTimeout(timer);\n  }\n}\n\nexport async function getJson<T = unknown>(\n  url: string,\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<T | null> {\n  try {\n    const res = await timedFetch(url, {}, timeoutMs);\n    if (!res.ok) return null;\n    return (await res.json()) as T;\n  } catch {\n    return null;\n  }\n}\n\n/**\n * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS\n * heading, collapse whitespace, and truncate on a sentence boundary.\n */\nexport function cleanSection(value: unknown, maxChars = MAX_FIELD_CHARS): string {\n  if (!value) return \"\";\n  let text = Array.isArray(value) ? value.join(\"\\n\\n\") : String(value);\n\n  text = text\n    .replace(/\\r/g, \"\")\n    .replace(/[ \\t]+/g, \" \")\n    .replace(/\\n{3,}/g, \"\\n\\n\")\n    .trim();\n\n  // Drop a leading section header line like \"5 WARNINGS AND PRECAUTIONS\"\n  text = text.replace(/^\\s*\\d+(\\.\\d+)*\\s+[A-Z][A-Z \\-/,&]+\\n+/, \"\").trim();\n\n  if (text.length > maxChars) {\n    const slice = text.slice(0, maxChars);\n    const lastStop = Math.max(slice.lastIndexOf(\". \"), slice.lastIndexOf(\"\\n\"));\n    text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + \" …\";\n  }\n  return text;\n}\n\nexport function formatFdaDate(yyyymmdd?: string): string {\n  if (!yyyymmdd || !/^\\d{8}$/.test(yyyymmdd)) return \"\";\n  const d = new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);\n  if (isNaN(d.getTime())) return \"\";\n  return d.toLocaleDateString(\"en-US\", { year: \"numeric\", month: \"short\", day: \"numeric\" });\n}\n\nexport function titleCase(s: string): string {\n  return String(s || \"\").replace(/\\w\\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());\n}\n\nexport function uniq<T>(arr: T[]): T[] {\n  return [...new Set(arr.filter(Boolean))];\n}\n","/**\n * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA\n * fallback. No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n  const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n  const id = exact?.idGroup?.rxnormId?.[0];\n  if (id) return id;\n\n  const approx = await getJson<any>(\n    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n    TIMEOUT_MS\n  );\n  const cand = approx?.approximateGroup?.candidate?.[0];\n  return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === tty);\n  if (!g || !g.conceptProperties) return [];\n  return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n  const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n  const groups = data?.relatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === \"SBDF\");\n  if (!g || !g.conceptProperties) return [];\n  const brands: string[] = [];\n  for (const c of g.conceptProperties) {\n    const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n    if (!m) continue;\n    const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n    if (prefix.includes(\"/\")) continue; // combination product — skip\n    brands.push(m[1].trim());\n  }\n  return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n  rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n  const data = await getJson<any>(\n    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n    TIMEOUT_MS\n  );\n  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n  const byType = (t: string): string | null => {\n    const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n    return hit ? hit.rxclassMinConceptItem.className : null;\n  };\n  // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n  const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n  const uses = uniq<string>(\n    items\n      .filter((i: any) => i.rela === \"may_treat\")\n      .map((i: any) => i.rxclassMinConceptItem.className as string)\n  ).slice(0, 6);\n\n  return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n  const rxcui = await findRxcui(name);\n  if (!rxcui) return null;\n\n  const [props, allRelated] = await Promise.all([\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n  ]);\n\n  const tty: string | undefined = props?.properties?.tty;\n  const canonicalName: string = props?.properties?.name ?? name;\n  if (!tty) return null;\n\n  const inNames = collectNames(allRelated, \"IN\");\n  const minNames = collectNames(allRelated, \"MIN\");\n\n  const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n  const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n  // For a generic, list only brands where it is the sole active ingredient.\n  let brandNames: string[] | null = null;\n  if (!isBrand) {\n    const single = await getSingleIngredientBrands(rxcui);\n    const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n    brandNames = single.length ? single : fallback;\n  }\n\n  // Generic name must reflect the concept's OWN ingredient(s). A single-ingredient\n  // lookup (e.g. \"atorvastatin\", tty IN) relates to every combination it appears\n  // in (Atorvastatin / Ezetimibe, ...), so the previous MIN-first logic\n  // mis-resolved single generics to arbitrary combinations and broke downstream\n  // label lookups. When the input concept is itself an ingredient (IN) or a\n  // multi-ingredient concept (MIN), its own canonical name is authoritative;\n  // only for brands/products do we read the related MIN as the combo generic.\n  let genericName: string | null = null;\n  if (tty === \"IN\" || tty === \"MIN\") {\n    genericName = titleCase(canonicalName);\n  } else if (minNames.length) {\n    genericName = titleCase(minNames[0]);\n  } else if (inNames.length === 1) {\n    genericName = titleCase(inNames[0]);\n  } else if (inNames.length > 1) {\n    genericName = titleCase(uniq(inNames).join(\" / \"));\n  } else {\n    genericName = titleCase(canonicalName);\n  }\n\n  // Class + indications from the ingredient rxcui where possible.\n  const classRxcui = !isBrand\n    ? rxcui\n    : (() => {\n        const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n        return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n      })();\n  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n  return {\n    inputType,\n    inputName: titleCase(canonicalName),\n    genericName,\n    brandNames,\n    drugClass,\n    uses,\n    rxcui,\n    source: \"RxNorm (NLM)\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n  const q = name.replace(/\"/g, \"\");\n  const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n  const data = await getJson<any>(url, TIMEOUT_MS);\n  const fda = data?.results?.[0]?.openfda;\n  if (!fda) return null;\n\n  const brand = (fda.brand_name ?? [])[0] ?? \"\";\n  const generic = (fda.generic_name ?? [])[0] ?? \"\";\n  if (!brand && !generic) return null;\n\n  const isBrand = brand.toLowerCase() === name.toLowerCase();\n  return {\n    inputType: isBrand ? \"brand\" : \"generic\",\n    inputName: titleCase(name),\n    genericName: generic ? titleCase(generic) : null,\n    brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n    uses: [],\n    rxcui: null,\n    source: \"openFDA\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n  if (!name || !name.trim()) return null;\n  const clean = name.trim();\n  const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n  if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n    return viaRx;\n  }\n  return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n *   - US:    FDA label via the openFDA API  -> DailyMed citation\n *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Two layers:\n *   - getUsLabel / getUkSmpc  — general, all-section access (LabelSection[]),\n *     used by PubCrawl's get_uspi / get_smpc / compare_labels tools.\n *   - getUspi / getSmpc / getLabels — a 5-field convenience view (RegionLabel)\n *     used by Pharmonym. Built on the same fetch + parse internals.\n *\n * Every network call is best-effort: failures return null. Pure fetch + parse;\n * caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult, LabelSection, UsLabelResult, UkSmpcResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n  effective_time?: string;\n  boxed_warning?: string[];\n  indications_and_usage?: string[];\n  dosage_and_administration?: string[];\n  dosage_forms_and_strengths?: string[];\n  contraindications?: string[];\n  warnings_and_cautions?: string[];\n  warnings?: string[];\n  adverse_reactions?: string[];\n  drug_interactions?: string[];\n  use_in_specific_populations?: string[];\n  overdosage?: string[];\n  clinical_pharmacology?: string[];\n  description?: string[];\n  how_supplied?: string[];\n  openfda?: {\n    generic_name?: string[];\n    brand_name?: string[];\n    spl_set_id?: string[];\n  };\n}\ninterface OpenFdaResponse {\n  results?: OpenFdaLabel[];\n}\n\n// openFDA field -> { LOINC code, display title }. Order = label reading order.\nconst US_SECTION_MAP: Array<{ field: keyof OpenFdaLabel; code: string; title: string }> = [\n  { field: \"boxed_warning\", code: \"34066-1\", title: \"Boxed Warning\" },\n  { field: \"indications_and_usage\", code: \"34067-9\", title: \"Indications and Usage\" },\n  { field: \"dosage_and_administration\", code: \"34068-7\", title: \"Dosage and Administration\" },\n  { field: \"dosage_forms_and_strengths\", code: \"43678-2\", title: \"Dosage Forms and Strengths\" },\n  { field: \"contraindications\", code: \"34070-3\", title: \"Contraindications\" },\n  { field: \"warnings_and_cautions\", code: \"43685-7\", title: \"Warnings and Precautions\" },\n  { field: \"warnings\", code: \"34071-1\", title: \"Warnings\" },\n  { field: \"adverse_reactions\", code: \"34084-4\", title: \"Adverse Reactions\" },\n  { field: \"drug_interactions\", code: \"34073-7\", title: \"Drug Interactions\" },\n  { field: \"use_in_specific_populations\", code: \"42228-7\", title: \"Use in Specific Populations\" },\n  { field: \"overdosage\", code: \"34088-5\", title: \"Overdosage\" },\n  { field: \"clinical_pharmacology\", code: \"34090-1\", title: \"Clinical Pharmacology\" },\n  { field: \"description\", code: \"34089-3\", title: \"Description\" },\n  { field: \"how_supplied\", code: \"34069-5\", title: \"How Supplied\" },\n];\n\n/* --------------------------- US: openFDA --------------------------- */\n\nfunction score(r: OpenFdaLabel, q: string): number {\n  const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n  let s = 0;\n  if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n  if (g.includes(q.toLowerCase())) s += 1;\n  return s;\n}\n\n/** Fetch the most recent FDA label for a drug; prefers single-ingredient products. */\nasync function fetchOpenFdaBest(drug: string): Promise<OpenFdaLabel | null> {\n  if (!drug) return null;\n  const q = drug.trim().replace(/\"/g, \"\");\n  const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n  const data = await getJson<OpenFdaResponse>(url);\n  const results = data?.results ?? [];\n  if (results.length === 0) return null;\n  return results.slice().sort((a, b) => score(b, q) - score(a, q))[0];\n}\n\nfunction usMeta(r: OpenFdaLabel, fallbackName: string) {\n  const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n  const brand = r.openfda?.brand_name?.[0] ?? \"\";\n  const generic = r.openfda?.generic_name?.[0] ?? fallbackName;\n  return {\n    setId,\n    brand,\n    generic,\n    productName: brand ? `${brand} (${generic})` : generic,\n    dailymedUrl: setId\n      ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n      : \"https://dailymed.nlm.nih.gov/dailymed/\",\n  };\n}\n\nfunction matchesUsFilter(entry: { field: string; code: string; title: string }, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    return (\n      entry.code === req ||\n      entry.title.toLowerCase().includes(r) ||\n      String(entry.field).replace(/_/g, \" \").includes(r) ||\n      r.includes(entry.title.toLowerCase())\n    );\n  });\n}\n\n/**\n * General US label access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_uspi.\n */\nexport async function getUsLabel(drug: string, requested?: string[]): Promise<UsLabelResult | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const sections: LabelSection[] = [];\n  for (const entry of US_SECTION_MAP) {\n    if (requested?.length && !matchesUsFilter(entry, requested)) continue;\n    const content = cleanSection(r[entry.field]);\n    if (content) sections.push({ code: entry.code, title: entry.title, content });\n  }\n  if (sections.length === 0) return null;\n\n  return {\n    drugName: meta.productName,\n    setId: meta.setId,\n    publishedDate: formatFdaDate(r.effective_time),\n    sections,\n    dailymedUrl: meta.dailymedUrl,\n  };\n}\n\n/** 5-field convenience view of the US label (Pharmonym). */\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const dosage = cleanSection(r.dosage_and_administration);\n  const boxed = cleanSection(r.boxed_warning);\n  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n  const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n  const adverse = cleanSection(r.adverse_reactions);\n  const indications = cleanSection(r.indications_and_usage);\n  const contraindications = cleanSection(r.contraindications);\n\n  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n  return {\n    region: \"US\",\n    authority: \"FDA Prescribing Information\",\n    productName: meta.productName,\n    indications: indications || null,\n    dosage: dosage || null,\n    contraindications: contraindications || null,\n    warnings: warnings || null,\n    adverse: adverse || null,\n    updated: formatFdaDate(r.effective_time),\n    sourceUrl: meta.dailymedUrl,\n    sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n  };\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n  product_id: string;\n  name: string;\n}\n\nasync function searchEmcAll(drug: string): Promise<EmcMatch[]> {\n  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n  const res = await timedFetch(url);\n  if (!res.ok) return [];\n  const html = await res.text();\n  const $ = cheerio.load(html);\n  const out: EmcMatch[] = [];\n  $(\"a[href*='/emc/product/']\").each((_, el) => {\n    const href = $(el).attr(\"href\") || \"\";\n    const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n    if (!m) return;\n    const name = $(el).text().trim();\n    if (!name || name.toLowerCase().includes(\"health professional\")) return;\n    if (out.some((x) => x.product_id === m[1])) return;\n    out.push({ product_id: m[1], name });\n  });\n  return out;\n}\n\nasync function searchEmcBest(drug: string): Promise<EmcMatch | null> {\n  const matches = await searchEmcAll(drug);\n  if (matches.length === 0) return null;\n  const q = drug.toLowerCase();\n  matches.sort(\n    (a, b) =>\n      (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n  );\n  return matches[0];\n}\n\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n  \"4.1\": \"Therapeutic indications\",\n  \"4.2\": \"Posology and method of administration\",\n  \"4.3\": \"Contraindications\",\n  \"4.4\": \"Special warnings and precautions for use\",\n  \"4.5\": \"Interaction with other medicinal products\",\n  \"4.6\": \"Fertility, pregnancy and lactation\",\n  \"4.7\": \"Effects on ability to drive and use machines\",\n  \"4.8\": \"Undesirable effects\",\n  \"4.9\": \"Overdose\",\n  \"5.1\": \"Pharmacodynamic properties\",\n  \"5.2\": \"Pharmacokinetic properties\",\n  \"5.3\": \"Preclinical safety data\",\n  \"6.1\": \"List of excipients\",\n  \"6.2\": \"Incompatibilities\",\n  \"6.3\": \"Shelf life\",\n  \"6.4\": \"Special precautions for storage\",\n  \"6.5\": \"Nature and contents of container\",\n  \"6.6\": \"Special precautions for disposal\",\n};\n\nfunction htmlToText(html: string): string {\n  const $ = cheerio.load(html);\n  $(\"br\").replaceWith(\"\\n\");\n  $(\"li\").each((_, el) => {\n    $(el).prepend(\"- \");\n    $(el).append(\"\\n\");\n  });\n  $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n    $(el).append(\"\\n\");\n  });\n  return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\nfunction matchesSmpcFilter(code: string, title: string, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    if (code === req || code === r) return true;\n    if (title.toLowerCase().includes(r)) return true;\n    if (r.includes(\"indication\")) return code === \"4.1\";\n    if (r.includes(\"dosage\") || r.includes(\"dosing\") || r.includes(\"posology\")) return code === \"4.2\";\n    if (r.includes(\"contraindication\")) return code === \"4.3\";\n    if (r.includes(\"warning\") || r.includes(\"precaution\")) return code === \"4.4\";\n    if (r.includes(\"interaction\")) return code === \"4.5\";\n    if (r.includes(\"pregnancy\") || r.includes(\"fertility\")) return code === \"4.6\";\n    if (r.includes(\"adverse\") || r.includes(\"undesirable\") || r.includes(\"side effect\")) return code === \"4.8\";\n    if (r.includes(\"overdose\") || r.includes(\"overdosage\")) return code === \"4.9\";\n    if (r.includes(\"pharmacodynamic\")) return code === \"5.1\";\n    if (r.includes(\"pharmacokinetic\")) return code === \"5.2\";\n    return false;\n  });\n}\n\n/**\n * Parse SmPC sections from eMC HTML. Returns every detected numbered section as\n * LabelSection[] (or the requested subset). Detect numbered headings, collect\n * sibling content up to the next heading, with a parent-text fallback.\n */\nfunction parseSmpcSections(html: string, requested?: string[]): LabelSection[] {\n  const $ = cheerio.load(html);\n  const sectionElements: Array<{ code: string; title: string; element: any }> = [];\n\n  $(\"[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4\").each((_, el) => {\n    const text = $(el).text().trim();\n    const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n    if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });\n  });\n\n  if (sectionElements.length === 0) {\n    $(\"*\").each((_, el) => {\n      const $el = $(el);\n      if ($el.children().length > 0 && !$el.is(\"a, span, strong, em, b, i\")) return;\n      const text = $el.text().trim();\n      const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n      if (match && SMPC_SECTION_NAMES[match[1]]) {\n        sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });\n      }\n    });\n  }\n\n  const out: LabelSection[] = [];\n  for (let i = 0; i < sectionElements.length; i++) {\n    const current = sectionElements[i];\n    const next = sectionElements[i + 1];\n\n    let content = \"\";\n    let node = current.element.next();\n    while (node.length > 0) {\n      if (next && node.is(next.element)) break;\n      const nodeHtml = $.html(node);\n      if (nodeHtml) content += htmlToText(nodeHtml) + \"\\n\";\n      node = node.next();\n    }\n    if (!content.trim()) {\n      const parentHtml = $.html(current.element.parent());\n      if (parentHtml) content = htmlToText(parentHtml).replace(current.element.text().trim(), \"\").trim();\n    }\n\n    const cleaned = cleanSection(content);\n    if (cleaned) out.push({ code: current.code, title: current.title, content: cleaned });\n  }\n\n  if (requested?.length) {\n    return out.filter((s) => matchesSmpcFilter(s.code, s.title, requested));\n  }\n  return out;\n}\n\n/**\n * General UK/EU SmPC access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_smpc.\n */\nexport async function getUkSmpc(drug: string, requested?: string[]): Promise<UkSmpcResult | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const sections = parseSmpcSections(await res.text(), requested);\n    if (sections.length === 0) return null;\n    return {\n      drugName: best.name,\n      productId: best.product_id,\n      sections,\n      url: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n    };\n  } catch {\n    return null;\n  }\n}\n\n/** 5-field convenience view of the UK/EU SmPC (Pharmonym). */\nexport async function getSmpc(drug: string): Promise<RegionLabel | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const all = parseSmpcSections(await res.text());\n    const pick = (code: string) => all.find((s) => s.code === code)?.content ?? null;\n\n    const indications = pick(\"4.1\");\n    const dosage = pick(\"4.2\");\n    const contraindications = pick(\"4.3\");\n    const warnings = pick(\"4.4\");\n    const adverse = pick(\"4.8\");\n    if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n    return {\n      region: \"UK/EU\",\n      authority: \"Summary of Product Characteristics (SmPC)\",\n      productName: best.name,\n      indications,\n      dosage,\n      contraindications,\n      warnings,\n      adverse,\n      updated: \"\",\n      sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n      sourceLabel: \"electronic medicines compendium (emc), UK\",\n    };\n  } catch {\n    return null;\n  }\n}\n\n/* --------------------------- public API ---------------------------- */\n\n/** Look up both 5-field labels for a drug. Each side is null if unavailable. */\nexport async function getLabels(drug: string): Promise<LabelResult> {\n  const [us, uk] = await Promise.all([\n    getUspi(drug).catch(() => null),\n    getSmpc(drug).catch(() => null),\n  ]);\n  return { us, uk };\n}\n","/**\n * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.\n */\n\nimport { getLabels } from \"./labels.js\";\nimport type { CompareResult, LabelComparison } from \"./types.js\";\n\ntype LabelField = \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\";\n\n/** Topics compared across US and UK labels, mapped to the fields that hold them. */\nexport const SECTION_MAP: Array<{ topic: string; field: LabelField }> = [\n  { topic: \"Indications\", field: \"indications\" },\n  { topic: \"Dosing\", field: \"dosage\" },\n  { topic: \"Contraindications\", field: \"contraindications\" },\n  { topic: \"Warnings\", field: \"warnings\" },\n  { topic: \"Adverse Reactions\", field: \"adverse\" },\n];\n\nexport async function compareLabels(drug: string): Promise<CompareResult> {\n  const { us, uk } = await getLabels(drug);\n\n  const comparisons: LabelComparison[] = SECTION_MAP.map(({ topic, field }) => ({\n    topic,\n    us: us ? us[field] : null,\n    uk: uk ? uk[field] : null,\n  })).filter((c) => c.us || c.uk);\n\n  return {\n    drug,\n    comparisons,\n    usSource: us?.sourceUrl ?? null,\n    ukSource: uk?.sourceUrl ?? null,\n  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package/dist/index.js

@@ -123,9 +123,17 @@ async function resolveViaRxNorm(name) {
     brandNames = single.length ? single : fallback;
   }
   let genericName = null;
-  if (minNames.length) genericName = titleCase(minNames[0]);
-  else if (inNames.length === 1) genericName = titleCase(inNames[0]);
-  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(" / "));
+  if (tty === "IN" || tty === "MIN") {
+    genericName = titleCase(canonicalName);
+  } else if (minNames.length) {
+    genericName = titleCase(minNames[0]);
+  } else if (inNames.length === 1) {
+    genericName = titleCase(inNames[0]);
+  } else if (inNames.length > 1) {
+    genericName = titleCase(uniq(inNames).join(" / "));
+  } else {
+    genericName = titleCase(canonicalName);
+  }
   const classRxcui = !isBrand ? rxcui : (() => {
     const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x) => x.tty === "IN");
     return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;

package/dist/index.js.map

@@ -1 +1 @@
-{"version":3,"sources":["../src/fetch.ts","../src/names.ts","../src/labels.ts","../src/compare.ts"],"sourcesContent":["/**\n * Shared HTTP + text helpers. Uses the runtime's global `fetch` (Node >=18),\n * so the package has no node-fetch dependency.\n */\n\nconst DEFAULT_TIMEOUT_MS = 12000;\nconst MAX_FIELD_CHARS = 1400;\n\nexport const USER_AGENT = \"drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)\";\n\nexport async function timedFetch(\n  url: string,\n  opts: RequestInit = {},\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<Response> {\n  const controller = new AbortController();\n  const timer = setTimeout(() => controller.abort(), timeoutMs);\n  try {\n    return await fetch(url, {\n      ...opts,\n      signal: controller.signal,\n      headers: { \"User-Agent\": USER_AGENT, ...((opts.headers as Record<string, string>) || {}) },\n    });\n  } finally {\n    clearTimeout(timer);\n  }\n}\n\nexport async function getJson<T = unknown>(\n  url: string,\n  timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<T | null> {\n  try {\n    const res = await timedFetch(url, {}, timeoutMs);\n    if (!res.ok) return null;\n    return (await res.json()) as T;\n  } catch {\n    return null;\n  }\n}\n\n/**\n * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS\n * heading, collapse whitespace, and truncate on a sentence boundary.\n */\nexport function cleanSection(value: unknown, maxChars = MAX_FIELD_CHARS): string {\n  if (!value) return \"\";\n  let text = Array.isArray(value) ? value.join(\"\\n\\n\") : String(value);\n\n  text = text\n    .replace(/\\r/g, \"\")\n    .replace(/[ \\t]+/g, \" \")\n    .replace(/\\n{3,}/g, \"\\n\\n\")\n    .trim();\n\n  // Drop a leading section header line like \"5 WARNINGS AND PRECAUTIONS\"\n  text = text.replace(/^\\s*\\d+(\\.\\d+)*\\s+[A-Z][A-Z \\-/,&]+\\n+/, \"\").trim();\n\n  if (text.length > maxChars) {\n    const slice = text.slice(0, maxChars);\n    const lastStop = Math.max(slice.lastIndexOf(\". \"), slice.lastIndexOf(\"\\n\"));\n    text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + \" …\";\n  }\n  return text;\n}\n\nexport function formatFdaDate(yyyymmdd?: string): string {\n  if (!yyyymmdd || !/^\\d{8}$/.test(yyyymmdd)) return \"\";\n  const d = new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);\n  if (isNaN(d.getTime())) return \"\";\n  return d.toLocaleDateString(\"en-US\", { year: \"numeric\", month: \"short\", day: \"numeric\" });\n}\n\nexport function titleCase(s: string): string {\n  return String(s || \"\").replace(/\\w\\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());\n}\n\nexport function uniq<T>(arr: T[]): T[] {\n  return [...new Set(arr.filter(Boolean))];\n}\n","/**\n * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA\n * fallback. No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n  const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n  const id = exact?.idGroup?.rxnormId?.[0];\n  if (id) return id;\n\n  const approx = await getJson<any>(\n    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n    TIMEOUT_MS\n  );\n  const cand = approx?.approximateGroup?.candidate?.[0];\n  return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === tty);\n  if (!g || !g.conceptProperties) return [];\n  return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n  const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n  const groups = data?.relatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === \"SBDF\");\n  if (!g || !g.conceptProperties) return [];\n  const brands: string[] = [];\n  for (const c of g.conceptProperties) {\n    const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n    if (!m) continue;\n    const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n    if (prefix.includes(\"/\")) continue; // combination product — skip\n    brands.push(m[1].trim());\n  }\n  return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n  rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n  const data = await getJson<any>(\n    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n    TIMEOUT_MS\n  );\n  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n  const byType = (t: string): string | null => {\n    const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n    return hit ? hit.rxclassMinConceptItem.className : null;\n  };\n  // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n  const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n  const uses = uniq<string>(\n    items\n      .filter((i: any) => i.rela === \"may_treat\")\n      .map((i: any) => i.rxclassMinConceptItem.className as string)\n  ).slice(0, 6);\n\n  return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n  const rxcui = await findRxcui(name);\n  if (!rxcui) return null;\n\n  const [props, allRelated] = await Promise.all([\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n  ]);\n\n  const tty: string | undefined = props?.properties?.tty;\n  const canonicalName: string = props?.properties?.name ?? name;\n  if (!tty) return null;\n\n  const inNames = collectNames(allRelated, \"IN\");\n  const minNames = collectNames(allRelated, \"MIN\");\n\n  const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n  const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n  // For a generic, list only brands where it is the sole active ingredient.\n  let brandNames: string[] | null = null;\n  if (!isBrand) {\n    const single = await getSingleIngredientBrands(rxcui);\n    const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n    brandNames = single.length ? single : fallback;\n  }\n\n  // Generic display name: prefer the canonical combo string, else single, else joined.\n  let genericName: string | null = null;\n  if (minNames.length) genericName = titleCase(minNames[0]);\n  else if (inNames.length === 1) genericName = titleCase(inNames[0]);\n  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(\" / \"));\n\n  // Class + indications from the ingredient rxcui where possible.\n  const classRxcui = !isBrand\n    ? rxcui\n    : (() => {\n        const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n        return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n      })();\n  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n  return {\n    inputType,\n    inputName: titleCase(canonicalName),\n    genericName,\n    brandNames,\n    drugClass,\n    uses,\n    rxcui,\n    source: \"RxNorm (NLM)\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n  const q = name.replace(/\"/g, \"\");\n  const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n  const data = await getJson<any>(url, TIMEOUT_MS);\n  const fda = data?.results?.[0]?.openfda;\n  if (!fda) return null;\n\n  const brand = (fda.brand_name ?? [])[0] ?? \"\";\n  const generic = (fda.generic_name ?? [])[0] ?? \"\";\n  if (!brand && !generic) return null;\n\n  const isBrand = brand.toLowerCase() === name.toLowerCase();\n  return {\n    inputType: isBrand ? \"brand\" : \"generic\",\n    inputName: titleCase(name),\n    genericName: generic ? titleCase(generic) : null,\n    brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n    uses: [],\n    rxcui: null,\n    source: \"openFDA\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n  if (!name || !name.trim()) return null;\n  const clean = name.trim();\n  const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n  if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n    return viaRx;\n  }\n  return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n *   - US:    FDA label via the openFDA API  -> DailyMed citation\n *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Two layers:\n *   - getUsLabel / getUkSmpc  — general, all-section access (LabelSection[]),\n *     used by PubCrawl's get_uspi / get_smpc / compare_labels tools.\n *   - getUspi / getSmpc / getLabels — a 5-field convenience view (RegionLabel)\n *     used by Pharmonym. Built on the same fetch + parse internals.\n *\n * Every network call is best-effort: failures return null. Pure fetch + parse;\n * caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult, LabelSection, UsLabelResult, UkSmpcResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n  effective_time?: string;\n  boxed_warning?: string[];\n  indications_and_usage?: string[];\n  dosage_and_administration?: string[];\n  dosage_forms_and_strengths?: string[];\n  contraindications?: string[];\n  warnings_and_cautions?: string[];\n  warnings?: string[];\n  adverse_reactions?: string[];\n  drug_interactions?: string[];\n  use_in_specific_populations?: string[];\n  overdosage?: string[];\n  clinical_pharmacology?: string[];\n  description?: string[];\n  how_supplied?: string[];\n  openfda?: {\n    generic_name?: string[];\n    brand_name?: string[];\n    spl_set_id?: string[];\n  };\n}\ninterface OpenFdaResponse {\n  results?: OpenFdaLabel[];\n}\n\n// openFDA field -> { LOINC code, display title }. Order = label reading order.\nconst US_SECTION_MAP: Array<{ field: keyof OpenFdaLabel; code: string; title: string }> = [\n  { field: \"boxed_warning\", code: \"34066-1\", title: \"Boxed Warning\" },\n  { field: \"indications_and_usage\", code: \"34067-9\", title: \"Indications and Usage\" },\n  { field: \"dosage_and_administration\", code: \"34068-7\", title: \"Dosage and Administration\" },\n  { field: \"dosage_forms_and_strengths\", code: \"43678-2\", title: \"Dosage Forms and Strengths\" },\n  { field: \"contraindications\", code: \"34070-3\", title: \"Contraindications\" },\n  { field: \"warnings_and_cautions\", code: \"43685-7\", title: \"Warnings and Precautions\" },\n  { field: \"warnings\", code: \"34071-1\", title: \"Warnings\" },\n  { field: \"adverse_reactions\", code: \"34084-4\", title: \"Adverse Reactions\" },\n  { field: \"drug_interactions\", code: \"34073-7\", title: \"Drug Interactions\" },\n  { field: \"use_in_specific_populations\", code: \"42228-7\", title: \"Use in Specific Populations\" },\n  { field: \"overdosage\", code: \"34088-5\", title: \"Overdosage\" },\n  { field: \"clinical_pharmacology\", code: \"34090-1\", title: \"Clinical Pharmacology\" },\n  { field: \"description\", code: \"34089-3\", title: \"Description\" },\n  { field: \"how_supplied\", code: \"34069-5\", title: \"How Supplied\" },\n];\n\n/* --------------------------- US: openFDA --------------------------- */\n\nfunction score(r: OpenFdaLabel, q: string): number {\n  const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n  let s = 0;\n  if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n  if (g.includes(q.toLowerCase())) s += 1;\n  return s;\n}\n\n/** Fetch the most recent FDA label for a drug; prefers single-ingredient products. */\nasync function fetchOpenFdaBest(drug: string): Promise<OpenFdaLabel | null> {\n  if (!drug) return null;\n  const q = drug.trim().replace(/\"/g, \"\");\n  const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n  const data = await getJson<OpenFdaResponse>(url);\n  const results = data?.results ?? [];\n  if (results.length === 0) return null;\n  return results.slice().sort((a, b) => score(b, q) - score(a, q))[0];\n}\n\nfunction usMeta(r: OpenFdaLabel, fallbackName: string) {\n  const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n  const brand = r.openfda?.brand_name?.[0] ?? \"\";\n  const generic = r.openfda?.generic_name?.[0] ?? fallbackName;\n  return {\n    setId,\n    brand,\n    generic,\n    productName: brand ? `${brand} (${generic})` : generic,\n    dailymedUrl: setId\n      ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n      : \"https://dailymed.nlm.nih.gov/dailymed/\",\n  };\n}\n\nfunction matchesUsFilter(entry: { field: string; code: string; title: string }, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    return (\n      entry.code === req ||\n      entry.title.toLowerCase().includes(r) ||\n      String(entry.field).replace(/_/g, \" \").includes(r) ||\n      r.includes(entry.title.toLowerCase())\n    );\n  });\n}\n\n/**\n * General US label access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_uspi.\n */\nexport async function getUsLabel(drug: string, requested?: string[]): Promise<UsLabelResult | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const sections: LabelSection[] = [];\n  for (const entry of US_SECTION_MAP) {\n    if (requested?.length && !matchesUsFilter(entry, requested)) continue;\n    const content = cleanSection(r[entry.field]);\n    if (content) sections.push({ code: entry.code, title: entry.title, content });\n  }\n  if (sections.length === 0) return null;\n\n  return {\n    drugName: meta.productName,\n    setId: meta.setId,\n    publishedDate: formatFdaDate(r.effective_time),\n    sections,\n    dailymedUrl: meta.dailymedUrl,\n  };\n}\n\n/** 5-field convenience view of the US label (Pharmonym). */\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const dosage = cleanSection(r.dosage_and_administration);\n  const boxed = cleanSection(r.boxed_warning);\n  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n  const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n  const adverse = cleanSection(r.adverse_reactions);\n  const indications = cleanSection(r.indications_and_usage);\n  const contraindications = cleanSection(r.contraindications);\n\n  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n  return {\n    region: \"US\",\n    authority: \"FDA Prescribing Information\",\n    productName: meta.productName,\n    indications: indications || null,\n    dosage: dosage || null,\n    contraindications: contraindications || null,\n    warnings: warnings || null,\n    adverse: adverse || null,\n    updated: formatFdaDate(r.effective_time),\n    sourceUrl: meta.dailymedUrl,\n    sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n  };\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n  product_id: string;\n  name: string;\n}\n\nasync function searchEmcAll(drug: string): Promise<EmcMatch[]> {\n  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n  const res = await timedFetch(url);\n  if (!res.ok) return [];\n  const html = await res.text();\n  const $ = cheerio.load(html);\n  const out: EmcMatch[] = [];\n  $(\"a[href*='/emc/product/']\").each((_, el) => {\n    const href = $(el).attr(\"href\") || \"\";\n    const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n    if (!m) return;\n    const name = $(el).text().trim();\n    if (!name || name.toLowerCase().includes(\"health professional\")) return;\n    if (out.some((x) => x.product_id === m[1])) return;\n    out.push({ product_id: m[1], name });\n  });\n  return out;\n}\n\nasync function searchEmcBest(drug: string): Promise<EmcMatch | null> {\n  const matches = await searchEmcAll(drug);\n  if (matches.length === 0) return null;\n  const q = drug.toLowerCase();\n  matches.sort(\n    (a, b) =>\n      (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n  );\n  return matches[0];\n}\n\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n  \"4.1\": \"Therapeutic indications\",\n  \"4.2\": \"Posology and method of administration\",\n  \"4.3\": \"Contraindications\",\n  \"4.4\": \"Special warnings and precautions for use\",\n  \"4.5\": \"Interaction with other medicinal products\",\n  \"4.6\": \"Fertility, pregnancy and lactation\",\n  \"4.7\": \"Effects on ability to drive and use machines\",\n  \"4.8\": \"Undesirable effects\",\n  \"4.9\": \"Overdose\",\n  \"5.1\": \"Pharmacodynamic properties\",\n  \"5.2\": \"Pharmacokinetic properties\",\n  \"5.3\": \"Preclinical safety data\",\n  \"6.1\": \"List of excipients\",\n  \"6.2\": \"Incompatibilities\",\n  \"6.3\": \"Shelf life\",\n  \"6.4\": \"Special precautions for storage\",\n  \"6.5\": \"Nature and contents of container\",\n  \"6.6\": \"Special precautions for disposal\",\n};\n\nfunction htmlToText(html: string): string {\n  const $ = cheerio.load(html);\n  $(\"br\").replaceWith(\"\\n\");\n  $(\"li\").each((_, el) => {\n    $(el).prepend(\"- \");\n    $(el).append(\"\\n\");\n  });\n  $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n    $(el).append(\"\\n\");\n  });\n  return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\nfunction matchesSmpcFilter(code: string, title: string, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    if (code === req || code === r) return true;\n    if (title.toLowerCase().includes(r)) return true;\n    if (r.includes(\"indication\")) return code === \"4.1\";\n    if (r.includes(\"dosage\") || r.includes(\"dosing\") || r.includes(\"posology\")) return code === \"4.2\";\n    if (r.includes(\"contraindication\")) return code === \"4.3\";\n    if (r.includes(\"warning\") || r.includes(\"precaution\")) return code === \"4.4\";\n    if (r.includes(\"interaction\")) return code === \"4.5\";\n    if (r.includes(\"pregnancy\") || r.includes(\"fertility\")) return code === \"4.6\";\n    if (r.includes(\"adverse\") || r.includes(\"undesirable\") || r.includes(\"side effect\")) return code === \"4.8\";\n    if (r.includes(\"overdose\") || r.includes(\"overdosage\")) return code === \"4.9\";\n    if (r.includes(\"pharmacodynamic\")) return code === \"5.1\";\n    if (r.includes(\"pharmacokinetic\")) return code === \"5.2\";\n    return false;\n  });\n}\n\n/**\n * Parse SmPC sections from eMC HTML. Returns every detected numbered section as\n * LabelSection[] (or the requested subset). Detect numbered headings, collect\n * sibling content up to the next heading, with a parent-text fallback.\n */\nfunction parseSmpcSections(html: string, requested?: string[]): LabelSection[] {\n  const $ = cheerio.load(html);\n  const sectionElements: Array<{ code: string; title: string; element: any }> = [];\n\n  $(\"[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4\").each((_, el) => {\n    const text = $(el).text().trim();\n    const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n    if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });\n  });\n\n  if (sectionElements.length === 0) {\n    $(\"*\").each((_, el) => {\n      const $el = $(el);\n      if ($el.children().length > 0 && !$el.is(\"a, span, strong, em, b, i\")) return;\n      const text = $el.text().trim();\n      const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n      if (match && SMPC_SECTION_NAMES[match[1]]) {\n        sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });\n      }\n    });\n  }\n\n  const out: LabelSection[] = [];\n  for (let i = 0; i < sectionElements.length; i++) {\n    const current = sectionElements[i];\n    const next = sectionElements[i + 1];\n\n    let content = \"\";\n    let node = current.element.next();\n    while (node.length > 0) {\n      if (next && node.is(next.element)) break;\n      const nodeHtml = $.html(node);\n      if (nodeHtml) content += htmlToText(nodeHtml) + \"\\n\";\n      node = node.next();\n    }\n    if (!content.trim()) {\n      const parentHtml = $.html(current.element.parent());\n      if (parentHtml) content = htmlToText(parentHtml).replace(current.element.text().trim(), \"\").trim();\n    }\n\n    const cleaned = cleanSection(content);\n    if (cleaned) out.push({ code: current.code, title: current.title, content: cleaned });\n  }\n\n  if (requested?.length) {\n    return out.filter((s) => matchesSmpcFilter(s.code, s.title, requested));\n  }\n  return out;\n}\n\n/**\n * General UK/EU SmPC access — returns every available section (or the requested\n * subset) as LabelSection[]. 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No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n  const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n  const id = exact?.idGroup?.rxnormId?.[0];\n  if (id) return id;\n\n  const approx = await getJson<any>(\n    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n    TIMEOUT_MS\n  );\n  const cand = approx?.approximateGroup?.candidate?.[0];\n  return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === tty);\n  if (!g || !g.conceptProperties) return [];\n  return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n  const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n  const groups = data?.relatedGroup?.conceptGroup ?? [];\n  const g = groups.find((x: any) => x.tty === \"SBDF\");\n  if (!g || !g.conceptProperties) return [];\n  const brands: string[] = [];\n  for (const c of g.conceptProperties) {\n    const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n    if (!m) continue;\n    const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n    if (prefix.includes(\"/\")) continue; // combination product — skip\n    brands.push(m[1].trim());\n  }\n  return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n  rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n  const data = await getJson<any>(\n    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n    TIMEOUT_MS\n  );\n  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n  const byType = (t: string): string | null => {\n    const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n    return hit ? hit.rxclassMinConceptItem.className : null;\n  };\n  // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n  const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n  const uses = uniq<string>(\n    items\n      .filter((i: any) => i.rela === \"may_treat\")\n      .map((i: any) => i.rxclassMinConceptItem.className as string)\n  ).slice(0, 6);\n\n  return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n  const rxcui = await findRxcui(name);\n  if (!rxcui) return null;\n\n  const [props, allRelated] = await Promise.all([\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n    getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n  ]);\n\n  const tty: string | undefined = props?.properties?.tty;\n  const canonicalName: string = props?.properties?.name ?? name;\n  if (!tty) return null;\n\n  const inNames = collectNames(allRelated, \"IN\");\n  const minNames = collectNames(allRelated, \"MIN\");\n\n  const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n  const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n  // For a generic, list only brands where it is the sole active ingredient.\n  let brandNames: string[] | null = null;\n  if (!isBrand) {\n    const single = await getSingleIngredientBrands(rxcui);\n    const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n    brandNames = single.length ? single : fallback;\n  }\n\n  // Generic name must reflect the concept's OWN ingredient(s). A single-ingredient\n  // lookup (e.g. \"atorvastatin\", tty IN) relates to every combination it appears\n  // in (Atorvastatin / Ezetimibe, ...), so the previous MIN-first logic\n  // mis-resolved single generics to arbitrary combinations and broke downstream\n  // label lookups. When the input concept is itself an ingredient (IN) or a\n  // multi-ingredient concept (MIN), its own canonical name is authoritative;\n  // only for brands/products do we read the related MIN as the combo generic.\n  let genericName: string | null = null;\n  if (tty === \"IN\" || tty === \"MIN\") {\n    genericName = titleCase(canonicalName);\n  } else if (minNames.length) {\n    genericName = titleCase(minNames[0]);\n  } else if (inNames.length === 1) {\n    genericName = titleCase(inNames[0]);\n  } else if (inNames.length > 1) {\n    genericName = titleCase(uniq(inNames).join(\" / \"));\n  } else {\n    genericName = titleCase(canonicalName);\n  }\n\n  // Class + indications from the ingredient rxcui where possible.\n  const classRxcui = !isBrand\n    ? rxcui\n    : (() => {\n        const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n        return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n      })();\n  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n  return {\n    inputType,\n    inputName: titleCase(canonicalName),\n    genericName,\n    brandNames,\n    drugClass,\n    uses,\n    rxcui,\n    source: \"RxNorm (NLM)\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n  const q = name.replace(/\"/g, \"\");\n  const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n  const data = await getJson<any>(url, TIMEOUT_MS);\n  const fda = data?.results?.[0]?.openfda;\n  if (!fda) return null;\n\n  const brand = (fda.brand_name ?? [])[0] ?? \"\";\n  const generic = (fda.generic_name ?? [])[0] ?? \"\";\n  if (!brand && !generic) return null;\n\n  const isBrand = brand.toLowerCase() === name.toLowerCase();\n  return {\n    inputType: isBrand ? \"brand\" : \"generic\",\n    inputName: titleCase(name),\n    genericName: generic ? titleCase(generic) : null,\n    brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n    uses: [],\n    rxcui: null,\n    source: \"openFDA\",\n    regionNote: REGION_NOTE,\n  };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n  if (!name || !name.trim()) return null;\n  const clean = name.trim();\n  const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n  if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n    return viaRx;\n  }\n  return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n *   - US:    FDA label via the openFDA API  -> DailyMed citation\n *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Two layers:\n *   - getUsLabel / getUkSmpc  — general, all-section access (LabelSection[]),\n *     used by PubCrawl's get_uspi / get_smpc / compare_labels tools.\n *   - getUspi / getSmpc / getLabels — a 5-field convenience view (RegionLabel)\n *     used by Pharmonym. Built on the same fetch + parse internals.\n *\n * Every network call is best-effort: failures return null. Pure fetch + parse;\n * caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult, LabelSection, UsLabelResult, UkSmpcResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n  effective_time?: string;\n  boxed_warning?: string[];\n  indications_and_usage?: string[];\n  dosage_and_administration?: string[];\n  dosage_forms_and_strengths?: string[];\n  contraindications?: string[];\n  warnings_and_cautions?: string[];\n  warnings?: string[];\n  adverse_reactions?: string[];\n  drug_interactions?: string[];\n  use_in_specific_populations?: string[];\n  overdosage?: string[];\n  clinical_pharmacology?: string[];\n  description?: string[];\n  how_supplied?: string[];\n  openfda?: {\n    generic_name?: string[];\n    brand_name?: string[];\n    spl_set_id?: string[];\n  };\n}\ninterface OpenFdaResponse {\n  results?: OpenFdaLabel[];\n}\n\n// openFDA field -> { LOINC code, display title }. Order = label reading order.\nconst US_SECTION_MAP: Array<{ field: keyof OpenFdaLabel; code: string; title: string }> = [\n  { field: \"boxed_warning\", code: \"34066-1\", title: \"Boxed Warning\" },\n  { field: \"indications_and_usage\", code: \"34067-9\", title: \"Indications and Usage\" },\n  { field: \"dosage_and_administration\", code: \"34068-7\", title: \"Dosage and Administration\" },\n  { field: \"dosage_forms_and_strengths\", code: \"43678-2\", title: \"Dosage Forms and Strengths\" },\n  { field: \"contraindications\", code: \"34070-3\", title: \"Contraindications\" },\n  { field: \"warnings_and_cautions\", code: \"43685-7\", title: \"Warnings and Precautions\" },\n  { field: \"warnings\", code: \"34071-1\", title: \"Warnings\" },\n  { field: \"adverse_reactions\", code: \"34084-4\", title: \"Adverse Reactions\" },\n  { field: \"drug_interactions\", code: \"34073-7\", title: \"Drug Interactions\" },\n  { field: \"use_in_specific_populations\", code: \"42228-7\", title: \"Use in Specific Populations\" },\n  { field: \"overdosage\", code: \"34088-5\", title: \"Overdosage\" },\n  { field: \"clinical_pharmacology\", code: \"34090-1\", title: \"Clinical Pharmacology\" },\n  { field: \"description\", code: \"34089-3\", title: \"Description\" },\n  { field: \"how_supplied\", code: \"34069-5\", title: \"How Supplied\" },\n];\n\n/* --------------------------- US: openFDA --------------------------- */\n\nfunction score(r: OpenFdaLabel, q: string): number {\n  const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n  let s = 0;\n  if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n  if (g.includes(q.toLowerCase())) s += 1;\n  return s;\n}\n\n/** Fetch the most recent FDA label for a drug; prefers single-ingredient products. */\nasync function fetchOpenFdaBest(drug: string): Promise<OpenFdaLabel | null> {\n  if (!drug) return null;\n  const q = drug.trim().replace(/\"/g, \"\");\n  const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n  const data = await getJson<OpenFdaResponse>(url);\n  const results = data?.results ?? [];\n  if (results.length === 0) return null;\n  return results.slice().sort((a, b) => score(b, q) - score(a, q))[0];\n}\n\nfunction usMeta(r: OpenFdaLabel, fallbackName: string) {\n  const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n  const brand = r.openfda?.brand_name?.[0] ?? \"\";\n  const generic = r.openfda?.generic_name?.[0] ?? fallbackName;\n  return {\n    setId,\n    brand,\n    generic,\n    productName: brand ? `${brand} (${generic})` : generic,\n    dailymedUrl: setId\n      ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n      : \"https://dailymed.nlm.nih.gov/dailymed/\",\n  };\n}\n\nfunction matchesUsFilter(entry: { field: string; code: string; title: string }, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    return (\n      entry.code === req ||\n      entry.title.toLowerCase().includes(r) ||\n      String(entry.field).replace(/_/g, \" \").includes(r) ||\n      r.includes(entry.title.toLowerCase())\n    );\n  });\n}\n\n/**\n * General US label access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_uspi.\n */\nexport async function getUsLabel(drug: string, requested?: string[]): Promise<UsLabelResult | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const sections: LabelSection[] = [];\n  for (const entry of US_SECTION_MAP) {\n    if (requested?.length && !matchesUsFilter(entry, requested)) continue;\n    const content = cleanSection(r[entry.field]);\n    if (content) sections.push({ code: entry.code, title: entry.title, content });\n  }\n  if (sections.length === 0) return null;\n\n  return {\n    drugName: meta.productName,\n    setId: meta.setId,\n    publishedDate: formatFdaDate(r.effective_time),\n    sections,\n    dailymedUrl: meta.dailymedUrl,\n  };\n}\n\n/** 5-field convenience view of the US label (Pharmonym). */\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n  const r = await fetchOpenFdaBest(drug);\n  if (!r) return null;\n  const meta = usMeta(r, drug.trim());\n\n  const dosage = cleanSection(r.dosage_and_administration);\n  const boxed = cleanSection(r.boxed_warning);\n  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n  const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n  const adverse = cleanSection(r.adverse_reactions);\n  const indications = cleanSection(r.indications_and_usage);\n  const contraindications = cleanSection(r.contraindications);\n\n  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n  return {\n    region: \"US\",\n    authority: \"FDA Prescribing Information\",\n    productName: meta.productName,\n    indications: indications || null,\n    dosage: dosage || null,\n    contraindications: contraindications || null,\n    warnings: warnings || null,\n    adverse: adverse || null,\n    updated: formatFdaDate(r.effective_time),\n    sourceUrl: meta.dailymedUrl,\n    sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n  };\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n  product_id: string;\n  name: string;\n}\n\nasync function searchEmcAll(drug: string): Promise<EmcMatch[]> {\n  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n  const res = await timedFetch(url);\n  if (!res.ok) return [];\n  const html = await res.text();\n  const $ = cheerio.load(html);\n  const out: EmcMatch[] = [];\n  $(\"a[href*='/emc/product/']\").each((_, el) => {\n    const href = $(el).attr(\"href\") || \"\";\n    const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n    if (!m) return;\n    const name = $(el).text().trim();\n    if (!name || name.toLowerCase().includes(\"health professional\")) return;\n    if (out.some((x) => x.product_id === m[1])) return;\n    out.push({ product_id: m[1], name });\n  });\n  return out;\n}\n\nasync function searchEmcBest(drug: string): Promise<EmcMatch | null> {\n  const matches = await searchEmcAll(drug);\n  if (matches.length === 0) return null;\n  const q = drug.toLowerCase();\n  matches.sort(\n    (a, b) =>\n      (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n  );\n  return matches[0];\n}\n\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n  \"4.1\": \"Therapeutic indications\",\n  \"4.2\": \"Posology and method of administration\",\n  \"4.3\": \"Contraindications\",\n  \"4.4\": \"Special warnings and precautions for use\",\n  \"4.5\": \"Interaction with other medicinal products\",\n  \"4.6\": \"Fertility, pregnancy and lactation\",\n  \"4.7\": \"Effects on ability to drive and use machines\",\n  \"4.8\": \"Undesirable effects\",\n  \"4.9\": \"Overdose\",\n  \"5.1\": \"Pharmacodynamic properties\",\n  \"5.2\": \"Pharmacokinetic properties\",\n  \"5.3\": \"Preclinical safety data\",\n  \"6.1\": \"List of excipients\",\n  \"6.2\": \"Incompatibilities\",\n  \"6.3\": \"Shelf life\",\n  \"6.4\": \"Special precautions for storage\",\n  \"6.5\": \"Nature and contents of container\",\n  \"6.6\": \"Special precautions for disposal\",\n};\n\nfunction htmlToText(html: string): string {\n  const $ = cheerio.load(html);\n  $(\"br\").replaceWith(\"\\n\");\n  $(\"li\").each((_, el) => {\n    $(el).prepend(\"- \");\n    $(el).append(\"\\n\");\n  });\n  $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n    $(el).append(\"\\n\");\n  });\n  return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\nfunction matchesSmpcFilter(code: string, title: string, requested: string[]): boolean {\n  return requested.some((req) => {\n    const r = req.toLowerCase().trim();\n    if (code === req || code === r) return true;\n    if (title.toLowerCase().includes(r)) return true;\n    if (r.includes(\"indication\")) return code === \"4.1\";\n    if (r.includes(\"dosage\") || r.includes(\"dosing\") || r.includes(\"posology\")) return code === \"4.2\";\n    if (r.includes(\"contraindication\")) return code === \"4.3\";\n    if (r.includes(\"warning\") || r.includes(\"precaution\")) return code === \"4.4\";\n    if (r.includes(\"interaction\")) return code === \"4.5\";\n    if (r.includes(\"pregnancy\") || r.includes(\"fertility\")) return code === \"4.6\";\n    if (r.includes(\"adverse\") || r.includes(\"undesirable\") || r.includes(\"side effect\")) return code === \"4.8\";\n    if (r.includes(\"overdose\") || r.includes(\"overdosage\")) return code === \"4.9\";\n    if (r.includes(\"pharmacodynamic\")) return code === \"5.1\";\n    if (r.includes(\"pharmacokinetic\")) return code === \"5.2\";\n    return false;\n  });\n}\n\n/**\n * Parse SmPC sections from eMC HTML. Returns every detected numbered section as\n * LabelSection[] (or the requested subset). Detect numbered headings, collect\n * sibling content up to the next heading, with a parent-text fallback.\n */\nfunction parseSmpcSections(html: string, requested?: string[]): LabelSection[] {\n  const $ = cheerio.load(html);\n  const sectionElements: Array<{ code: string; title: string; element: any }> = [];\n\n  $(\"[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4\").each((_, el) => {\n    const text = $(el).text().trim();\n    const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n    if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });\n  });\n\n  if (sectionElements.length === 0) {\n    $(\"*\").each((_, el) => {\n      const $el = $(el);\n      if ($el.children().length > 0 && !$el.is(\"a, span, strong, em, b, i\")) return;\n      const text = $el.text().trim();\n      const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n      if (match && SMPC_SECTION_NAMES[match[1]]) {\n        sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });\n      }\n    });\n  }\n\n  const out: LabelSection[] = [];\n  for (let i = 0; i < sectionElements.length; i++) {\n    const current = sectionElements[i];\n    const next = sectionElements[i + 1];\n\n    let content = \"\";\n    let node = current.element.next();\n    while (node.length > 0) {\n      if (next && node.is(next.element)) break;\n      const nodeHtml = $.html(node);\n      if (nodeHtml) content += htmlToText(nodeHtml) + \"\\n\";\n      node = node.next();\n    }\n    if (!content.trim()) {\n      const parentHtml = $.html(current.element.parent());\n      if (parentHtml) content = htmlToText(parentHtml).replace(current.element.text().trim(), \"\").trim();\n    }\n\n    const cleaned = cleanSection(content);\n    if (cleaned) out.push({ code: current.code, title: current.title, content: cleaned });\n  }\n\n  if (requested?.length) {\n    return out.filter((s) => matchesSmpcFilter(s.code, s.title, requested));\n  }\n  return out;\n}\n\n/**\n * General UK/EU SmPC access — returns every available section (or the requested\n * subset) as LabelSection[]. Powers PubCrawl's get_smpc.\n */\nexport async function getUkSmpc(drug: string, requested?: string[]): Promise<UkSmpcResult | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const sections = parseSmpcSections(await res.text(), requested);\n    if (sections.length === 0) return null;\n    return {\n      drugName: best.name,\n      productId: best.product_id,\n      sections,\n      url: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n    };\n  } catch {\n    return null;\n  }\n}\n\n/** 5-field convenience view of the UK/EU SmPC (Pharmonym). */\nexport async function getSmpc(drug: string): Promise<RegionLabel | null> {\n  if (!drug) return null;\n  try {\n    const best = await searchEmcBest(drug);\n    if (!best) return null;\n    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n    if (!res.ok) return null;\n    const all = parseSmpcSections(await res.text());\n    const pick = (code: string) => all.find((s) => s.code === code)?.content ?? null;\n\n    const indications = pick(\"4.1\");\n    const dosage = pick(\"4.2\");\n    const contraindications = pick(\"4.3\");\n    const warnings = pick(\"4.4\");\n    const adverse = pick(\"4.8\");\n    if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n    return {\n      region: \"UK/EU\",\n      authority: \"Summary of Product Characteristics (SmPC)\",\n      productName: best.name,\n      indications,\n      dosage,\n      contraindications,\n      warnings,\n      adverse,\n      updated: \"\",\n      sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n      sourceLabel: \"electronic medicines compendium (emc), UK\",\n    };\n  } catch {\n    return null;\n  }\n}\n\n/* --------------------------- public API ---------------------------- */\n\n/** Look up both 5-field labels for a drug. Each side is null if unavailable. */\nexport async function getLabels(drug: string): Promise<LabelResult> {\n  const [us, uk] = await Promise.all([\n    getUspi(drug).catch(() => null),\n    getSmpc(drug).catch(() => null),\n  ]);\n  return { us, uk };\n}\n","/**\n * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.\n */\n\nimport { getLabels } from \"./labels.js\";\nimport type { CompareResult, LabelComparison } from \"./types.js\";\n\ntype LabelField = \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\";\n\n/** Topics compared across US and UK labels, mapped to the fields that hold them. */\nexport const SECTION_MAP: Array<{ topic: string; field: LabelField }> = [\n  { topic: \"Indications\", field: \"indications\" },\n  { topic: \"Dosing\", field: \"dosage\" },\n  { topic: \"Contraindications\", field: \"contraindications\" },\n  { topic: \"Warnings\", field: \"warnings\" },\n  { topic: \"Adverse Reactions\", field: 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package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@pharmatools/drug-data",
-  "version": "0.2.0",
+  "version": "0.2.1",
   "description": "Deterministic drug-name resolution (RxNorm) and official label data (FDA openFDA + UK eMC SmPC), with US/UK comparison. The shared engine behind Pharmonym and PubCrawl.",
   "type": "module",
   "exports": {