npm - @pharmatools/drug-data - Versions diffs - 0.1.0 - Mend

@pharmatools/drug-data 0.1.0

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package/README.md ADDED Viewed

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+# @pharmatools/drug-data
+Shared drug-data engine behind [Pharmonym](https://www.pharmatools.ai/pharmonym)
+and [PubCrawl](https://www.pharmatools.ai/pubcrawl). Deterministic, sourced,
+no AI.
+- **Name resolution** — brand ⇄ generic, drug class and indications via
+  RxNorm/RxNav, with openFDA fallback.
+- **Labels** — dosage, warnings, contraindications, indications and adverse
+  reactions from the US FDA label (openFDA, cited to DailyMed) and the UK/EU
+  SmPC (eMC / medicines.org.uk).
+- **Comparison** — equivalent US ↔ UK label sections mapped side by side.
+Pure fetch + parse: no caching, no secrets. Wraps public government APIs.
+Dual-built (ESM + CJS), global `fetch`, Node ≥18.
+## Install
+```bash
+npm install @pharmatools/drug-data
+```
+## Usage
+```ts
+import { resolveName, getLabels, compareLabels } from "@pharmatools/drug-data";
+await resolveName("Lipitor");
+// { inputType: "brand", genericName: "Atorvastatin", drugClass: "...", ... }
+await getLabels("atorvastatin");
+// { us: { dosage, warnings, ... , sourceUrl }, uk: { ... } }
+await compareLabels("atorvastatin");
+// { drug, comparisons: [{ topic, us, uk }], usSource, ukSource }
+```
+CommonJS consumers use `require("@pharmatools/drug-data")` — same API.
+## Develop
+```bash
+npm install
+npm test       # vitest (mocked fixtures, no network)
+npm run build  # tsup -> dist/{index.js,index.cjs,index.d.ts}
+```
+## Sources
+RxNorm/RxNav, openFDA, DailyMed, eMC (medicines.org.uk). Not a substitute for
+professional medical advice; always verify against the full prescribing
+information.

package/dist/index.cjs ADDED Viewed

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+"use strict";
+var __create = Object.create;
+var __defProp = Object.defineProperty;
+var __getOwnPropDesc = Object.getOwnPropertyDescriptor;
+var __getOwnPropNames = Object.getOwnPropertyNames;
+var __getProtoOf = Object.getPrototypeOf;
+var __hasOwnProp = Object.prototype.hasOwnProperty;
+var __export = (target, all) => {
+  for (var name in all)
+    __defProp(target, name, { get: all[name], enumerable: true });
+};
+var __copyProps = (to, from, except, desc) => {
+  if (from && typeof from === "object" || typeof from === "function") {
+    for (let key of __getOwnPropNames(from))
+      if (!__hasOwnProp.call(to, key) && key !== except)
+        __defProp(to, key, { get: () => from[key], enumerable: !(desc = __getOwnPropDesc(from, key)) || desc.enumerable });
+  }
+  return to;
+};
+var __toESM = (mod, isNodeMode, target) => (target = mod != null ? __create(__getProtoOf(mod)) : {}, __copyProps(
+  // If the importer is in node compatibility mode or this is not an ESM
+  // file that has been converted to a CommonJS file using a Babel-
+  // compatible transform (i.e. "__esModule" has not been set), then set
+  // "default" to the CommonJS "module.exports" for node compatibility.
+  isNodeMode || !mod || !mod.__esModule ? __defProp(target, "default", { value: mod, enumerable: true }) : target,
+  mod
+));
+var __toCommonJS = (mod) => __copyProps(__defProp({}, "__esModule", { value: true }), mod);
+// src/index.ts
+var index_exports = {};
+__export(index_exports, {
+  SECTION_MAP: () => SECTION_MAP,
+  cleanSection: () => cleanSection,
+  compareLabels: () => compareLabels,
+  formatFdaDate: () => formatFdaDate,
+  getLabels: () => getLabels,
+  getSmpc: () => getSmpc,
+  getUspi: () => getUspi,
+  resolveName: () => resolveName
+});
+module.exports = __toCommonJS(index_exports);
+// src/fetch.ts
+var DEFAULT_TIMEOUT_MS = 12e3;
+var MAX_FIELD_CHARS = 1400;
+var USER_AGENT = "drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)";
+async function timedFetch(url, opts = {}, timeoutMs = DEFAULT_TIMEOUT_MS) {
+  const controller = new AbortController();
+  const timer = setTimeout(() => controller.abort(), timeoutMs);
+  try {
+    return await fetch(url, {
+      ...opts,
+      signal: controller.signal,
+      headers: { "User-Agent": USER_AGENT, ...opts.headers || {} }
+    });
+  } finally {
+    clearTimeout(timer);
+  }
+}
+async function getJson(url, timeoutMs = DEFAULT_TIMEOUT_MS) {
+  try {
+    const res = await timedFetch(url, {}, timeoutMs);
+    if (!res.ok) return null;
+    return await res.json();
+  } catch {
+    return null;
+  }
+}
+function cleanSection(value, maxChars = MAX_FIELD_CHARS) {
+  if (!value) return "";
+  let text = Array.isArray(value) ? value.join("\n\n") : String(value);
+  text = text.replace(/\r/g, "").replace(/[ \t]+/g, " ").replace(/\n{3,}/g, "\n\n").trim();
+  text = text.replace(/^\s*\d+(\.\d+)*\s+[A-Z][A-Z \-/,&]+\n+/, "").trim();
+  if (text.length > maxChars) {
+    const slice = text.slice(0, maxChars);
+    const lastStop = Math.max(slice.lastIndexOf(". "), slice.lastIndexOf("\n"));
+    text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + " \u2026";
+  }
+  return text;
+}
+function formatFdaDate(yyyymmdd) {
+  if (!yyyymmdd || !/^\d{8}$/.test(yyyymmdd)) return "";
+  const d = /* @__PURE__ */ new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);
+  if (isNaN(d.getTime())) return "";
+  return d.toLocaleDateString("en-US", { year: "numeric", month: "short", day: "numeric" });
+}
+function titleCase(s) {
+  return String(s || "").replace(/\w\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());
+}
+function uniq(arr) {
+  return [...new Set(arr.filter(Boolean))];
+}
+// src/names.ts
+var RXNAV = "https://rxnav.nlm.nih.gov/REST";
+var OPENFDA = "https://api.fda.gov/drug/label.json";
+var TIMEOUT_MS = 1e4;
+var REGION_NOTE = "Brand names shown are those registered in the United States.";
+async function findRxcui(name) {
+  const exact = await getJson(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);
+  const id = exact?.idGroup?.rxnormId?.[0];
+  if (id) return id;
+  const approx = await getJson(
+    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,
+    TIMEOUT_MS
+  );
+  const cand = approx?.approximateGroup?.candidate?.[0];
+  return cand ? cand.rxcui : null;
+}
+function collectNames(allRelated, tty) {
+  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];
+  const g = groups.find((x) => x.tty === tty);
+  if (!g || !g.conceptProperties) return [];
+  return g.conceptProperties.map((c) => c.name);
+}
+async function getSingleIngredientBrands(ingredientRxcui) {
+  const data = await getJson(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);
+  const groups = data?.relatedGroup?.conceptGroup ?? [];
+  const g = groups.find((x) => x.tty === "SBDF");
+  if (!g || !g.conceptProperties) return [];
+  const brands = [];
+  for (const c of g.conceptProperties) {
+    const m = c.name.match(/\[([^\]]+)\]\s*$/);
+    if (!m) continue;
+    const prefix = c.name.slice(0, c.name.lastIndexOf("["));
+    if (prefix.includes("/")) continue;
+    brands.push(m[1].trim());
+  }
+  return uniq(brands).sort();
+}
+async function getDrugClassAndUses(rxcui) {
+  const data = await getJson(
+    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,
+    TIMEOUT_MS
+  );
+  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];
+  const byType = (t) => {
+    const hit = items.find((i) => i.rxclassMinConceptItem.classType === t);
+    return hit ? hit.rxclassMinConceptItem.className : null;
+  };
+  const drugClass = byType("EPC") || byType("MOA") || byType("CHEM");
+  const uses = uniq(
+    items.filter((i) => i.rela === "may_treat").map((i) => i.rxclassMinConceptItem.className)
+  ).slice(0, 6);
+  return { drugClass, uses };
+}
+async function resolveViaRxNorm(name) {
+  const rxcui = await findRxcui(name);
+  if (!rxcui) return null;
+  const [props, allRelated] = await Promise.all([
+    getJson(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),
+    getJson(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS)
+  ]);
+  const tty = props?.properties?.tty;
+  const canonicalName = props?.properties?.name ?? name;
+  if (!tty) return null;
+  const inNames = collectNames(allRelated, "IN");
+  const minNames = collectNames(allRelated, "MIN");
+  const isBrand = tty === "BN" || tty === "SBD" || tty === "BPCK";
+  const inputType = isBrand ? "brand" : "generic";
+  let brandNames = null;
+  if (!isBrand) {
+    const single = await getSingleIngredientBrands(rxcui);
+    const fallback = uniq([...collectNames(allRelated, "BN"), ...collectNames(allRelated, "BPCK")]).sort();
+    brandNames = single.length ? single : fallback;
+  }
+  let genericName = null;
+  if (minNames.length) genericName = titleCase(minNames[0]);
+  else if (inNames.length === 1) genericName = titleCase(inNames[0]);
+  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(" / "));
+  const classRxcui = !isBrand ? rxcui : (() => {
+    const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x) => x.tty === "IN");
+    return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;
+  })();
+  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);
+  return {
+    inputType,
+    inputName: titleCase(canonicalName),
+    genericName,
+    brandNames,
+    drugClass,
+    uses,
+    rxcui,
+    source: "RxNorm (NLM)",
+    regionNote: REGION_NOTE
+  };
+}
+async function resolveViaOpenFda(name) {
+  const q = name.replace(/"/g, "");
+  const search = `(openfda.brand_name:"${q}"+OR+openfda.generic_name:"${q}")`;
+  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, "+")}&limit=1`;
+  const data = await getJson(url, TIMEOUT_MS);
+  const fda = data?.results?.[0]?.openfda;
+  if (!fda) return null;
+  const brand = (fda.brand_name ?? [])[0] ?? "";
+  const generic = (fda.generic_name ?? [])[0] ?? "";
+  if (!brand && !generic) return null;
+  const isBrand = brand.toLowerCase() === name.toLowerCase();
+  return {
+    inputType: isBrand ? "brand" : "generic",
+    inputName: titleCase(name),
+    genericName: generic ? titleCase(generic) : null,
+    brandNames: isBrand ? null : uniq(fda.brand_name ?? []).sort(),
+    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,
+    uses: [],
+    rxcui: null,
+    source: "openFDA",
+    regionNote: REGION_NOTE
+  };
+}
+async function resolveName(name) {
+  if (!name || !name.trim()) return null;
+  const clean = name.trim();
+  const viaRx = await resolveViaRxNorm(clean).catch(() => null);
+  if (viaRx && (viaRx.genericName || viaRx.brandNames && viaRx.brandNames.length)) {
+    return viaRx;
+  }
+  return await resolveViaOpenFda(clean).catch(() => null);
+}
+// src/labels.ts
+var cheerio = __toESM(require("cheerio"), 1);
+var OPENFDA_URL = "https://api.fda.gov/drug/label.json";
+var EMC_BASE = "https://www.medicines.org.uk";
+async function getUspi(drug) {
+  if (!drug) return null;
+  const q = drug.trim().replace(/"/g, "");
+  const search = `(openfda.generic_name:"${q}"+OR+openfda.brand_name:"${q}")`;
+  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, "+")}&sort=effective_time:desc&limit=5`;
+  const data = await getJson(url);
+  const results = data?.results ?? [];
+  if (results.length === 0) return null;
+  const ranked = results.slice().sort((a, b) => score(b, q) - score(a, q));
+  const r = ranked[0];
+  const dosage = cleanSection(r.dosage_and_administration);
+  const boxed = cleanSection(r.boxed_warning);
+  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);
+  const warnings = [boxed ? `BOXED WARNING \u2014 ${boxed}` : "", warn].filter(Boolean).join("\n\n");
+  const adverse = cleanSection(r.adverse_reactions);
+  const indications = cleanSection(r.indications_and_usage);
+  const contraindications = cleanSection(r.contraindications);
+  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;
+  const setId = r.openfda?.spl_set_id?.[0] ?? "";
+  const brand = r.openfda?.brand_name?.[0] ?? "";
+  const generic = r.openfda?.generic_name?.[0] ?? q;
+  return {
+    region: "US",
+    authority: "FDA Prescribing Information",
+    productName: brand ? `${brand} (${generic})` : generic,
+    indications: indications || null,
+    dosage: dosage || null,
+    contraindications: contraindications || null,
+    warnings: warnings || null,
+    adverse: adverse || null,
+    updated: formatFdaDate(r.effective_time),
+    sourceUrl: setId ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}` : "https://dailymed.nlm.nih.gov/dailymed/",
+    sourceLabel: "DailyMed (U.S. National Library of Medicine)"
+  };
+}
+function score(r, q) {
+  const g = (r.openfda?.generic_name ?? []).join(", ").toLowerCase();
+  let s = 0;
+  if (g && g.split(/,| and /).length === 1) s += 2;
+  if (g.includes(q.toLowerCase())) s += 1;
+  return s;
+}
+async function searchEmc(drug) {
+  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;
+  const res = await timedFetch(url);
+  if (!res.ok) return [];
+  const html = await res.text();
+  const $ = cheerio.load(html);
+  const out = [];
+  $("a[href*='/emc/product/']").each((_, el) => {
+    const href = $(el).attr("href") || "";
+    const m = href.match(/\/emc\/product\/(\d+)\/smpc/);
+    if (!m) return;
+    const name = $(el).text().trim();
+    if (!name || name.toLowerCase().includes("health professional")) return;
+    if (out.some((x) => x.product_id === m[1])) return;
+    out.push({ product_id: m[1], name });
+  });
+  return out;
+}
+var SMPC_WANT = {
+  "4.1": "indications",
+  "4.2": "dosage",
+  "4.3": "contraindications",
+  "4.4": "warnings",
+  "4.8": "adverse"
+};
+var SMPC_SECTION_NAMES = {
+  "4.1": "Therapeutic indications",
+  "4.2": "Posology and method of administration",
+  "4.3": "Contraindications",
+  "4.4": "Special warnings and precautions for use",
+  "4.5": "Interaction with other medicinal products",
+  "4.6": "Fertility, pregnancy and lactation",
+  "4.7": "Effects on ability to drive and use machines",
+  "4.8": "Undesirable effects",
+  "4.9": "Overdose",
+  "5.1": "Pharmacodynamic properties",
+  "5.2": "Pharmacokinetic properties",
+  "5.3": "Preclinical safety data"
+};
+function htmlToText(html) {
+  const $ = cheerio.load(html);
+  $("br").replaceWith("\n");
+  $("li").each((_, el) => {
+    $(el).prepend("- ");
+    $(el).append("\n");
+  });
+  $("p, div, tr, h1, h2, h3, h4, h5, h6").each((_, el) => {
+    $(el).append("\n");
+  });
+  return $.text().replace(/\n{3,}/g, "\n\n").trim();
+}
+function parseSmpcSections(html) {
+  const $ = cheerio.load(html);
+  const sectionElements = [];
+  $("[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4").each((_, el) => {
+    const text = $(el).text().trim();
+    const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+    if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });
+  });
+  if (sectionElements.length === 0) {
+    $("*").each((_, el) => {
+      const $el = $(el);
+      if ($el.children().length > 0 && !$el.is("a, span, strong, em, b, i")) return;
+      const text = $el.text().trim();
+      const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+      if (match && SMPC_SECTION_NAMES[match[1]]) {
+        sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });
+      }
+    });
+  }
+  const fields = {};
+  for (let i = 0; i < sectionElements.length; i++) {
+    const current = sectionElements[i];
+    const field = SMPC_WANT[current.code];
+    if (!field) continue;
+    const next = sectionElements[i + 1];
+    let content = "";
+    let node = current.element.next();
+    while (node.length > 0) {
+      if (next && node.is(next.element)) break;
+      const nodeHtml = $.html(node);
+      if (nodeHtml) content += htmlToText(nodeHtml) + "\n";
+      node = node.next();
+    }
+    if (!content.trim()) {
+      const parentHtml = $.html(current.element.parent());
+      if (parentHtml) {
+        content = htmlToText(parentHtml).replace(current.element.text().trim(), "").trim();
+      }
+    }
+    fields[field] = cleanSection(content);
+  }
+  return fields;
+}
+async function getSmpc(drug) {
+  if (!drug) return null;
+  try {
+    const matches = await searchEmc(drug);
+    if (matches.length === 0) return null;
+    const q = drug.toLowerCase();
+    matches.sort(
+      (a, b) => (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)
+    );
+    const best = matches[0];
+    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);
+    if (!res.ok) return null;
+    const html = await res.text();
+    const sec = parseSmpcSections(html);
+    if (!sec.dosage && !sec.warnings && !sec.adverse && !sec.indications && !sec.contraindications)
+      return null;
+    return {
+      region: "UK/EU",
+      authority: "Summary of Product Characteristics (SmPC)",
+      productName: best.name,
+      indications: sec.indications || null,
+      dosage: sec.dosage || null,
+      contraindications: sec.contraindications || null,
+      warnings: sec.warnings || null,
+      adverse: sec.adverse || null,
+      updated: "",
+      sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,
+      sourceLabel: "electronic medicines compendium (emc), UK"
+    };
+  } catch {
+    return null;
+  }
+}
+async function getLabels(drug) {
+  const [us, uk] = await Promise.all([
+    getUspi(drug).catch(() => null),
+    getSmpc(drug).catch(() => null)
+  ]);
+  return { us, uk };
+}
+// src/compare.ts
+var SECTION_MAP = [
+  { topic: "Indications", field: "indications" },
+  { topic: "Dosing", field: "dosage" },
+  { topic: "Contraindications", field: "contraindications" },
+  { topic: "Warnings", field: "warnings" },
+  { topic: "Adverse Reactions", field: "adverse" }
+];
+async function compareLabels(drug) {
+  const { us, uk } = await getLabels(drug);
+  const comparisons = SECTION_MAP.map(({ topic, field }) => ({
+    topic,
+    us: us ? us[field] : null,
+    uk: uk ? uk[field] : null
+  })).filter((c) => c.us || c.uk);
+  return {
+    drug,
+    comparisons,
+    usSource: us?.sourceUrl ?? null,
+    ukSource: uk?.sourceUrl ?? null
+  };
+}
+// Annotate the CommonJS export names for ESM import in node:
+0 && (module.exports = {
+  SECTION_MAP,
+  cleanSection,
+  compareLabels,
+  formatFdaDate,
+  getLabels,
+  getSmpc,
+  getUspi,
+  resolveName
+});
+//# sourceMappingURL=index.cjs.map

package/dist/index.cjs.map ADDED Viewed

@@ -0,0 +1 @@

+ {"version":3,"sources":["../src/index.ts","../src/fetch.ts","../src/names.ts","../src/labels.ts","../src/compare.ts"],"sourcesContent":["// @pharmatools/drug-data — public surface\n\nexport { resolveName } from \"./names.js\";\nexport { getUspi, getSmpc, getLabels } from \"./labels.js\";\nexport { compareLabels, SECTION_MAP } from \"./compare.js\";\nexport { cleanSection, formatFdaDate } from \"./fetch.js\";\nexport type {\n Region,\n RegionLabel,\n LabelResult,\n ResolveResult,\n LabelComparison,\n CompareResult,\n} from \"./types.js\";\n","/**\n * Shared HTTP + text helpers. Uses the runtime's global `fetch` (Node >=18),\n * so the package has no node-fetch dependency.\n */\n\nconst DEFAULT_TIMEOUT_MS = 12000;\nconst MAX_FIELD_CHARS = 1400;\n\nexport const USER_AGENT = \"drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)\";\n\nexport async function timedFetch(\n url: string,\n opts: RequestInit = {},\n timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<Response> {\n const controller = new AbortController();\n const timer = setTimeout(() => controller.abort(), timeoutMs);\n try {\n return await fetch(url, {\n ...opts,\n signal: controller.signal,\n headers: { \"User-Agent\": USER_AGENT, ...((opts.headers as Record<string, string>) || {}) },\n });\n } finally {\n clearTimeout(timer);\n }\n}\n\nexport async function getJson<T = unknown>(\n url: string,\n timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<T | null> {\n try {\n const res = await timedFetch(url, {}, timeoutMs);\n if (!res.ok) return null;\n return (await res.json()) as T;\n } catch {\n return null;\n }\n}\n\n/**\n * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS\n * heading, collapse whitespace, and truncate on a sentence boundary.\n */\nexport function cleanSection(value: unknown, maxChars = MAX_FIELD_CHARS): string {\n if (!value) return \"\";\n let text = Array.isArray(value) ? value.join(\"\\n\\n\") : String(value);\n\n text = text\n .replace(/\\r/g, \"\")\n .replace(/[ \\t]+/g, \" \")\n .replace(/\\n{3,}/g, \"\\n\\n\")\n .trim();\n\n // Drop a leading section header line like \"5 WARNINGS AND PRECAUTIONS\"\n text = text.replace(/^\\s*\\d+(\\.\\d+)*\\s+[A-Z][A-Z \\-/,&]+\\n+/, \"\").trim();\n\n if (text.length > maxChars) {\n const slice = text.slice(0, maxChars);\n const lastStop = Math.max(slice.lastIndexOf(\". \"), slice.lastIndexOf(\"\\n\"));\n text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + \" …\";\n }\n return text;\n}\n\nexport function formatFdaDate(yyyymmdd?: string): string {\n if (!yyyymmdd || !/^\\d{8}$/.test(yyyymmdd)) return \"\";\n const d = new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);\n if (isNaN(d.getTime())) return \"\";\n return d.toLocaleDateString(\"en-US\", { year: \"numeric\", month: \"short\", day: \"numeric\" });\n}\n\nexport function titleCase(s: string): string {\n return String(s || \"\").replace(/\\w\\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());\n}\n\nexport function uniq<T>(arr: T[]): T[] {\n return [...new Set(arr.filter(Boolean))];\n}\n","/**\n * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA\n * fallback. No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n const id = exact?.idGroup?.rxnormId?.[0];\n if (id) return id;\n\n const approx = await getJson<any>(\n `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n TIMEOUT_MS\n );\n const cand = approx?.approximateGroup?.candidate?.[0];\n return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n const g = groups.find((x: any) => x.tty === tty);\n if (!g || !g.conceptProperties) return [];\n return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n const groups = data?.relatedGroup?.conceptGroup ?? [];\n const g = groups.find((x: any) => x.tty === \"SBDF\");\n if (!g || !g.conceptProperties) return [];\n const brands: string[] = [];\n for (const c of g.conceptProperties) {\n const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n if (!m) continue;\n const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n if (prefix.includes(\"/\")) continue; // combination product — skip\n brands.push(m[1].trim());\n }\n return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n const data = await getJson<any>(\n `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n TIMEOUT_MS\n );\n const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n const byType = (t: string): string | null => {\n const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n return hit ? hit.rxclassMinConceptItem.className : null;\n };\n // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n const uses = uniq<string>(\n items\n .filter((i: any) => i.rela === \"may_treat\")\n .map((i: any) => i.rxclassMinConceptItem.className as string)\n ).slice(0, 6);\n\n return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n const rxcui = await findRxcui(name);\n if (!rxcui) return null;\n\n const [props, allRelated] = await Promise.all([\n getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n ]);\n\n const tty: string | undefined = props?.properties?.tty;\n const canonicalName: string = props?.properties?.name ?? name;\n if (!tty) return null;\n\n const inNames = collectNames(allRelated, \"IN\");\n const minNames = collectNames(allRelated, \"MIN\");\n\n const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n // For a generic, list only brands where it is the sole active ingredient.\n let brandNames: string[] | null = null;\n if (!isBrand) {\n const single = await getSingleIngredientBrands(rxcui);\n const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n brandNames = single.length ? single : fallback;\n }\n\n // Generic display name: prefer the canonical combo string, else single, else joined.\n let genericName: string | null = null;\n if (minNames.length) genericName = titleCase(minNames[0]);\n else if (inNames.length === 1) genericName = titleCase(inNames[0]);\n else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(\" / \"));\n\n // Class + indications from the ingredient rxcui where possible.\n const classRxcui = !isBrand\n ? rxcui\n : (() => {\n const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n })();\n const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n return {\n inputType,\n inputName: titleCase(canonicalName),\n genericName,\n brandNames,\n drugClass,\n uses,\n rxcui,\n source: \"RxNorm (NLM)\",\n regionNote: REGION_NOTE,\n };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n const q = name.replace(/\"/g, \"\");\n const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n const data = await getJson<any>(url, TIMEOUT_MS);\n const fda = data?.results?.[0]?.openfda;\n if (!fda) return null;\n\n const brand = (fda.brand_name ?? [])[0] ?? \"\";\n const generic = (fda.generic_name ?? [])[0] ?? \"\";\n if (!brand && !generic) return null;\n\n const isBrand = brand.toLowerCase() === name.toLowerCase();\n return {\n inputType: isBrand ? \"brand\" : \"generic\",\n inputName: titleCase(name),\n genericName: generic ? titleCase(generic) : null,\n brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n uses: [],\n rxcui: null,\n source: \"openFDA\",\n regionNote: REGION_NOTE,\n };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n if (!name || !name.trim()) return null;\n const clean = name.trim();\n const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n return viaRx;\n }\n return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n * - US: FDA label via the openFDA API -> DailyMed citation\n * - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Every network call is best-effort: any failure returns null so callers never\n * break. Pure fetch + parse — caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n effective_time?: string;\n dosage_and_administration?: string[];\n boxed_warning?: string[];\n warnings_and_cautions?: string[];\n warnings?: string[];\n adverse_reactions?: string[];\n indications_and_usage?: string[];\n contraindications?: string[];\n openfda?: {\n generic_name?: string[];\n brand_name?: string[];\n spl_set_id?: string[];\n };\n}\ninterface OpenFdaResponse {\n results?: OpenFdaLabel[];\n}\n\n/* --------------------------- US: openFDA --------------------------- */\n\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n if (!drug) return null;\n const q = drug.trim().replace(/\"/g, \"\");\n const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n\n const data = await getJson<OpenFdaResponse>(url);\n const results = data?.results ?? [];\n if (results.length === 0) return null;\n\n // Prefer a single-ingredient product over combination labels.\n const ranked = results.slice().sort((a, b) => score(b, q) - score(a, q));\n const r = ranked[0];\n\n const dosage = cleanSection(r.dosage_and_administration);\n const boxed = cleanSection(r.boxed_warning);\n const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n const adverse = cleanSection(r.adverse_reactions);\n const indications = cleanSection(r.indications_and_usage);\n const contraindications = cleanSection(r.contraindications);\n\n if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n const brand = r.openfda?.brand_name?.[0] ?? \"\";\n const generic = r.openfda?.generic_name?.[0] ?? q;\n\n return {\n region: \"US\",\n authority: \"FDA Prescribing Information\",\n productName: brand ? `${brand} (${generic})` : generic,\n indications: indications || null,\n dosage: dosage || null,\n contraindications: contraindications || null,\n warnings: warnings || null,\n adverse: adverse || null,\n updated: formatFdaDate(r.effective_time),\n sourceUrl: setId\n ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n : \"https://dailymed.nlm.nih.gov/dailymed/\",\n sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n };\n}\n\nfunction score(r: OpenFdaLabel, q: string): number {\n const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n let s = 0;\n if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n if (g.includes(q.toLowerCase())) s += 1;\n return s;\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n product_id: string;\n name: string;\n}\n\nasync function searchEmc(drug: string): Promise<EmcMatch[]> {\n const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n const res = await timedFetch(url);\n if (!res.ok) return [];\n const html = await res.text();\n const $ = cheerio.load(html);\n const out: EmcMatch[] = [];\n $(\"a[href*='/emc/product/']\").each((_, el) => {\n const href = $(el).attr(\"href\") || \"\";\n const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n if (!m) return;\n const name = $(el).text().trim();\n if (!name || name.toLowerCase().includes(\"health professional\")) return;\n if (out.some((x) => x.product_id === m[1])) return;\n out.push({ product_id: m[1], name });\n });\n return out;\n}\n\n// SmPC section number -> the field we store it under\nconst SMPC_WANT: Record<string, keyof Pick<RegionLabel, \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\">> = {\n \"4.1\": \"indications\",\n \"4.2\": \"dosage\",\n \"4.3\": \"contraindications\",\n \"4.4\": \"warnings\",\n \"4.8\": \"adverse\",\n};\n\n// Canonical SmPC section titles — used as a fallback heading detector\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n \"4.1\": \"Therapeutic indications\",\n \"4.2\": \"Posology and method of administration\",\n \"4.3\": \"Contraindications\",\n \"4.4\": \"Special warnings and precautions for use\",\n \"4.5\": \"Interaction with other medicinal products\",\n \"4.6\": \"Fertility, pregnancy and lactation\",\n \"4.7\": \"Effects on ability to drive and use machines\",\n \"4.8\": \"Undesirable effects\",\n \"4.9\": \"Overdose\",\n \"5.1\": \"Pharmacodynamic properties\",\n \"5.2\": \"Pharmacokinetic properties\",\n \"5.3\": \"Preclinical safety data\",\n};\n\nfunction htmlToText(html: string): string {\n const $ = cheerio.load(html);\n $(\"br\").replaceWith(\"\\n\");\n $(\"li\").each((_, el) => {\n $(el).prepend(\"- \");\n $(el).append(\"\\n\");\n });\n $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n $(el).append(\"\\n\");\n });\n return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\n/**\n * Parse the wanted SmPC sections from eMC HTML. Detect numbered headings, then\n * collect sibling content up to the next heading, with a parent-text fallback.\n */\nfunction parseSmpcSections(html: string): Record<string, string> {\n const $ = cheerio.load(html);\n const sectionElements: Array<{ code: string; title: string; element: any }> = [];\n\n // Strategy 1: headings whose text starts with a section number\n $(\"[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4\").each((_, el) => {\n const text = $(el).text().trim();\n const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });\n });\n\n // Strategy 2: fall back to scanning leaf nodes for known section headers\n if (sectionElements.length === 0) {\n $(\"*\").each((_, el) => {\n const $el = $(el);\n if ($el.children().length > 0 && !$el.is(\"a, span, strong, em, b, i\")) return;\n const text = $el.text().trim();\n const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n if (match && SMPC_SECTION_NAMES[match[1]]) {\n sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });\n }\n });\n }\n\n const fields: Record<string, string> = {};\n for (let i = 0; i < sectionElements.length; i++) {\n const current = sectionElements[i];\n const field = SMPC_WANT[current.code];\n if (!field) continue;\n const next = sectionElements[i + 1];\n\n let content = \"\";\n let node = current.element.next();\n while (node.length > 0) {\n if (next && node.is(next.element)) break;\n const nodeHtml = $.html(node);\n if (nodeHtml) content += htmlToText(nodeHtml) + \"\\n\";\n node = node.next();\n }\n\n if (!content.trim()) {\n const parentHtml = $.html(current.element.parent());\n if (parentHtml) {\n content = htmlToText(parentHtml).replace(current.element.text().trim(), \"\").trim();\n }\n }\n\n fields[field] = cleanSection(content);\n }\n return fields;\n}\n\nexport async function getSmpc(drug: string): Promise<RegionLabel | null> {\n if (!drug) return null;\n try {\n const matches = await searchEmc(drug);\n if (matches.length === 0) return null;\n\n const q = drug.toLowerCase();\n matches.sort(\n (a, b) =>\n (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n );\n const best = matches[0];\n\n const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n if (!res.ok) return null;\n const html = await res.text();\n const sec = parseSmpcSections(html);\n\n if (!sec.dosage && !sec.warnings && !sec.adverse && !sec.indications && !sec.contraindications)\n return null;\n\n return {\n region: \"UK/EU\",\n authority: \"Summary of Product Characteristics (SmPC)\",\n productName: best.name,\n indications: sec.indications || null,\n dosage: sec.dosage || null,\n contraindications: sec.contraindications || null,\n warnings: sec.warnings || null,\n adverse: sec.adverse || null,\n updated: \"\",\n sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n sourceLabel: \"electronic medicines compendium (emc), UK\",\n };\n } catch {\n return null;\n }\n}\n\n/* --------------------------- public API ---------------------------- */\n\n/** Look up both labels for a drug. Each side is null if unavailable. Never throws. */\nexport async function getLabels(drug: string): Promise<LabelResult> {\n const [us, uk] = await Promise.all([\n getUspi(drug).catch(() => null),\n getSmpc(drug).catch(() => null),\n ]);\n return { us, uk };\n}\n","/**\n * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.\n */\n\nimport { getLabels } from \"./labels.js\";\nimport type { CompareResult, LabelComparison } from \"./types.js\";\n\ntype LabelField = \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\";\n\n/** Topics compared across US and UK labels, mapped to the fields that hold them. */\nexport const SECTION_MAP: Array<{ topic: string; field: LabelField }> = [\n { topic: \"Indications\", field: \"indications\" },\n { topic: \"Dosing\", field: \"dosage\" },\n { topic: \"Contraindications\", field: \"contraindications\" },\n { topic: \"Warnings\", field: \"warnings\" },\n { topic: \"Adverse Reactions\", field: \"adverse\" },\n];\n\nexport async function compareLabels(drug: string): Promise<CompareResult> {\n const { us, uk } = await getLabels(drug);\n\n const comparisons: LabelComparison[] = SECTION_MAP.map(({ topic, field }) => ({\n topic,\n us: us ? us[field] : null,\n uk: uk ? uk[field] : null,\n })).filter((c) => c.us || c.uk);\n\n return {\n drug,\n comparisons,\n usSource: us?.sourceUrl ?? null,\n ukSource: uk?.sourceUrl ?? null,\n 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package/dist/index.d.cts ADDED Viewed

@@ -0,0 +1,92 @@
+type Region = "US" | "UK/EU";
+/** One regional label (FDA USPI or UK/EU SmPC), cleaned and truncated. */
+interface RegionLabel {
+    region: Region;
+    authority: string;
+    productName: string;
+    indications: string | null;
+    dosage: string | null;
+    contraindications: string | null;
+    warnings: string | null;
+    adverse: string | null;
+    /** Human-readable revision date (US only; "" when unknown). */
+    updated: string;
+    sourceUrl: string;
+    sourceLabel: string;
+}
+interface LabelResult {
+    us: RegionLabel | null;
+    uk: RegionLabel | null;
+}
+/** Deterministic brand <-> generic resolution result. */
+interface ResolveResult {
+    inputType: "brand" | "generic";
+    inputName: string;
+    genericName: string | null;
+    /** US brand names (null when the input itself is a brand). */
+    brandNames: string[] | null;
+    drugClass: string | null;
+    uses: string[];
+    rxcui: string | null;
+    source: string;
+    regionNote: string;
+}
+/** One topic compared across US and UK labels. */
+interface LabelComparison {
+    topic: string;
+    us: string | null;
+    uk: string | null;
+}
+interface CompareResult {
+    drug: string;
+    comparisons: LabelComparison[];
+    usSource: string | null;
+    ukSource: string | null;
+}
+/**
+ * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA
+ * fallback. No AI, no hallucinated names. Brand names are US-registered;
+ * international brand names are intentionally not invented.
+ */
+/**
+ * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns
+ * null if neither source recognises the name.
+ */
+declare function resolveName(name: string): Promise<ResolveResult | null>;
+/**
+ * Official drug-label lookups.
+ *   - US:    FDA label via the openFDA API  -> DailyMed citation
+ *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation
+ *
+ * Every network call is best-effort: any failure returns null so callers never
+ * break. Pure fetch + parse — caching belongs to the consumer.
+ */
+declare function getUspi(drug: string): Promise<RegionLabel | null>;
+declare function getSmpc(drug: string): Promise<RegionLabel | null>;
+/** Look up both labels for a drug. Each side is null if unavailable. Never throws. */
+declare function getLabels(drug: string): Promise<LabelResult>;
+/**
+ * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.
+ */
+type LabelField = "indications" | "dosage" | "contraindications" | "warnings" | "adverse";
+/** Topics compared across US and UK labels, mapped to the fields that hold them. */
+declare const SECTION_MAP: Array<{
+    topic: string;
+    field: LabelField;
+}>;
+declare function compareLabels(drug: string): Promise<CompareResult>;
+/**
+ * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS
+ * heading, collapse whitespace, and truncate on a sentence boundary.
+ */
+declare function cleanSection(value: unknown, maxChars?: number): string;
+declare function formatFdaDate(yyyymmdd?: string): string;
+export { type CompareResult, type LabelComparison, type LabelResult, type Region, type RegionLabel, type ResolveResult, SECTION_MAP, cleanSection, compareLabels, formatFdaDate, getLabels, getSmpc, getUspi, resolveName };

package/dist/index.d.ts ADDED Viewed

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+type Region = "US" | "UK/EU";
+/** One regional label (FDA USPI or UK/EU SmPC), cleaned and truncated. */
+interface RegionLabel {
+    region: Region;
+    authority: string;
+    productName: string;
+    indications: string | null;
+    dosage: string | null;
+    contraindications: string | null;
+    warnings: string | null;
+    adverse: string | null;
+    /** Human-readable revision date (US only; "" when unknown). */
+    updated: string;
+    sourceUrl: string;
+    sourceLabel: string;
+}
+interface LabelResult {
+    us: RegionLabel | null;
+    uk: RegionLabel | null;
+}
+/** Deterministic brand <-> generic resolution result. */
+interface ResolveResult {
+    inputType: "brand" | "generic";
+    inputName: string;
+    genericName: string | null;
+    /** US brand names (null when the input itself is a brand). */
+    brandNames: string[] | null;
+    drugClass: string | null;
+    uses: string[];
+    rxcui: string | null;
+    source: string;
+    regionNote: string;
+}
+/** One topic compared across US and UK labels. */
+interface LabelComparison {
+    topic: string;
+    us: string | null;
+    uk: string | null;
+}
+interface CompareResult {
+    drug: string;
+    comparisons: LabelComparison[];
+    usSource: string | null;
+    ukSource: string | null;
+}
+/**
+ * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA
+ * fallback. No AI, no hallucinated names. Brand names are US-registered;
+ * international brand names are intentionally not invented.
+ */
+/**
+ * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns
+ * null if neither source recognises the name.
+ */
+declare function resolveName(name: string): Promise<ResolveResult | null>;
+/**
+ * Official drug-label lookups.
+ *   - US:    FDA label via the openFDA API  -> DailyMed citation
+ *   - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation
+ *
+ * Every network call is best-effort: any failure returns null so callers never
+ * break. Pure fetch + parse — caching belongs to the consumer.
+ */
+declare function getUspi(drug: string): Promise<RegionLabel | null>;
+declare function getSmpc(drug: string): Promise<RegionLabel | null>;
+/** Look up both labels for a drug. Each side is null if unavailable. Never throws. */
+declare function getLabels(drug: string): Promise<LabelResult>;
+/**
+ * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.
+ */
+type LabelField = "indications" | "dosage" | "contraindications" | "warnings" | "adverse";
+/** Topics compared across US and UK labels, mapped to the fields that hold them. */
+declare const SECTION_MAP: Array<{
+    topic: string;
+    field: LabelField;
+}>;
+declare function compareLabels(drug: string): Promise<CompareResult>;
+/**
+ * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS
+ * heading, collapse whitespace, and truncate on a sentence boundary.
+ */
+declare function cleanSection(value: unknown, maxChars?: number): string;
+declare function formatFdaDate(yyyymmdd?: string): string;
+export { type CompareResult, type LabelComparison, type LabelResult, type Region, type RegionLabel, type ResolveResult, SECTION_MAP, cleanSection, compareLabels, formatFdaDate, getLabels, getSmpc, getUspi, resolveName };

package/dist/index.js ADDED Viewed

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+// src/fetch.ts
+var DEFAULT_TIMEOUT_MS = 12e3;
+var MAX_FIELD_CHARS = 1400;
+var USER_AGENT = "drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)";
+async function timedFetch(url, opts = {}, timeoutMs = DEFAULT_TIMEOUT_MS) {
+  const controller = new AbortController();
+  const timer = setTimeout(() => controller.abort(), timeoutMs);
+  try {
+    return await fetch(url, {
+      ...opts,
+      signal: controller.signal,
+      headers: { "User-Agent": USER_AGENT, ...opts.headers || {} }
+    });
+  } finally {
+    clearTimeout(timer);
+  }
+}
+async function getJson(url, timeoutMs = DEFAULT_TIMEOUT_MS) {
+  try {
+    const res = await timedFetch(url, {}, timeoutMs);
+    if (!res.ok) return null;
+    return await res.json();
+  } catch {
+    return null;
+  }
+}
+function cleanSection(value, maxChars = MAX_FIELD_CHARS) {
+  if (!value) return "";
+  let text = Array.isArray(value) ? value.join("\n\n") : String(value);
+  text = text.replace(/\r/g, "").replace(/[ \t]+/g, " ").replace(/\n{3,}/g, "\n\n").trim();
+  text = text.replace(/^\s*\d+(\.\d+)*\s+[A-Z][A-Z \-/,&]+\n+/, "").trim();
+  if (text.length > maxChars) {
+    const slice = text.slice(0, maxChars);
+    const lastStop = Math.max(slice.lastIndexOf(". "), slice.lastIndexOf("\n"));
+    text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + " \u2026";
+  }
+  return text;
+}
+function formatFdaDate(yyyymmdd) {
+  if (!yyyymmdd || !/^\d{8}$/.test(yyyymmdd)) return "";
+  const d = /* @__PURE__ */ new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);
+  if (isNaN(d.getTime())) return "";
+  return d.toLocaleDateString("en-US", { year: "numeric", month: "short", day: "numeric" });
+}
+function titleCase(s) {
+  return String(s || "").replace(/\w\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());
+}
+function uniq(arr) {
+  return [...new Set(arr.filter(Boolean))];
+}
+// src/names.ts
+var RXNAV = "https://rxnav.nlm.nih.gov/REST";
+var OPENFDA = "https://api.fda.gov/drug/label.json";
+var TIMEOUT_MS = 1e4;
+var REGION_NOTE = "Brand names shown are those registered in the United States.";
+async function findRxcui(name) {
+  const exact = await getJson(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);
+  const id = exact?.idGroup?.rxnormId?.[0];
+  if (id) return id;
+  const approx = await getJson(
+    `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,
+    TIMEOUT_MS
+  );
+  const cand = approx?.approximateGroup?.candidate?.[0];
+  return cand ? cand.rxcui : null;
+}
+function collectNames(allRelated, tty) {
+  const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];
+  const g = groups.find((x) => x.tty === tty);
+  if (!g || !g.conceptProperties) return [];
+  return g.conceptProperties.map((c) => c.name);
+}
+async function getSingleIngredientBrands(ingredientRxcui) {
+  const data = await getJson(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);
+  const groups = data?.relatedGroup?.conceptGroup ?? [];
+  const g = groups.find((x) => x.tty === "SBDF");
+  if (!g || !g.conceptProperties) return [];
+  const brands = [];
+  for (const c of g.conceptProperties) {
+    const m = c.name.match(/\[([^\]]+)\]\s*$/);
+    if (!m) continue;
+    const prefix = c.name.slice(0, c.name.lastIndexOf("["));
+    if (prefix.includes("/")) continue;
+    brands.push(m[1].trim());
+  }
+  return uniq(brands).sort();
+}
+async function getDrugClassAndUses(rxcui) {
+  const data = await getJson(
+    `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,
+    TIMEOUT_MS
+  );
+  const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];
+  const byType = (t) => {
+    const hit = items.find((i) => i.rxclassMinConceptItem.classType === t);
+    return hit ? hit.rxclassMinConceptItem.className : null;
+  };
+  const drugClass = byType("EPC") || byType("MOA") || byType("CHEM");
+  const uses = uniq(
+    items.filter((i) => i.rela === "may_treat").map((i) => i.rxclassMinConceptItem.className)
+  ).slice(0, 6);
+  return { drugClass, uses };
+}
+async function resolveViaRxNorm(name) {
+  const rxcui = await findRxcui(name);
+  if (!rxcui) return null;
+  const [props, allRelated] = await Promise.all([
+    getJson(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),
+    getJson(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS)
+  ]);
+  const tty = props?.properties?.tty;
+  const canonicalName = props?.properties?.name ?? name;
+  if (!tty) return null;
+  const inNames = collectNames(allRelated, "IN");
+  const minNames = collectNames(allRelated, "MIN");
+  const isBrand = tty === "BN" || tty === "SBD" || tty === "BPCK";
+  const inputType = isBrand ? "brand" : "generic";
+  let brandNames = null;
+  if (!isBrand) {
+    const single = await getSingleIngredientBrands(rxcui);
+    const fallback = uniq([...collectNames(allRelated, "BN"), ...collectNames(allRelated, "BPCK")]).sort();
+    brandNames = single.length ? single : fallback;
+  }
+  let genericName = null;
+  if (minNames.length) genericName = titleCase(minNames[0]);
+  else if (inNames.length === 1) genericName = titleCase(inNames[0]);
+  else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(" / "));
+  const classRxcui = !isBrand ? rxcui : (() => {
+    const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x) => x.tty === "IN");
+    return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;
+  })();
+  const { drugClass, uses } = await getDrugClassAndUses(classRxcui);
+  return {
+    inputType,
+    inputName: titleCase(canonicalName),
+    genericName,
+    brandNames,
+    drugClass,
+    uses,
+    rxcui,
+    source: "RxNorm (NLM)",
+    regionNote: REGION_NOTE
+  };
+}
+async function resolveViaOpenFda(name) {
+  const q = name.replace(/"/g, "");
+  const search = `(openfda.brand_name:"${q}"+OR+openfda.generic_name:"${q}")`;
+  const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, "+")}&limit=1`;
+  const data = await getJson(url, TIMEOUT_MS);
+  const fda = data?.results?.[0]?.openfda;
+  if (!fda) return null;
+  const brand = (fda.brand_name ?? [])[0] ?? "";
+  const generic = (fda.generic_name ?? [])[0] ?? "";
+  if (!brand && !generic) return null;
+  const isBrand = brand.toLowerCase() === name.toLowerCase();
+  return {
+    inputType: isBrand ? "brand" : "generic",
+    inputName: titleCase(name),
+    genericName: generic ? titleCase(generic) : null,
+    brandNames: isBrand ? null : uniq(fda.brand_name ?? []).sort(),
+    drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,
+    uses: [],
+    rxcui: null,
+    source: "openFDA",
+    regionNote: REGION_NOTE
+  };
+}
+async function resolveName(name) {
+  if (!name || !name.trim()) return null;
+  const clean = name.trim();
+  const viaRx = await resolveViaRxNorm(clean).catch(() => null);
+  if (viaRx && (viaRx.genericName || viaRx.brandNames && viaRx.brandNames.length)) {
+    return viaRx;
+  }
+  return await resolveViaOpenFda(clean).catch(() => null);
+}
+// src/labels.ts
+import * as cheerio from "cheerio";
+var OPENFDA_URL = "https://api.fda.gov/drug/label.json";
+var EMC_BASE = "https://www.medicines.org.uk";
+async function getUspi(drug) {
+  if (!drug) return null;
+  const q = drug.trim().replace(/"/g, "");
+  const search = `(openfda.generic_name:"${q}"+OR+openfda.brand_name:"${q}")`;
+  const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, "+")}&sort=effective_time:desc&limit=5`;
+  const data = await getJson(url);
+  const results = data?.results ?? [];
+  if (results.length === 0) return null;
+  const ranked = results.slice().sort((a, b) => score(b, q) - score(a, q));
+  const r = ranked[0];
+  const dosage = cleanSection(r.dosage_and_administration);
+  const boxed = cleanSection(r.boxed_warning);
+  const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);
+  const warnings = [boxed ? `BOXED WARNING \u2014 ${boxed}` : "", warn].filter(Boolean).join("\n\n");
+  const adverse = cleanSection(r.adverse_reactions);
+  const indications = cleanSection(r.indications_and_usage);
+  const contraindications = cleanSection(r.contraindications);
+  if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;
+  const setId = r.openfda?.spl_set_id?.[0] ?? "";
+  const brand = r.openfda?.brand_name?.[0] ?? "";
+  const generic = r.openfda?.generic_name?.[0] ?? q;
+  return {
+    region: "US",
+    authority: "FDA Prescribing Information",
+    productName: brand ? `${brand} (${generic})` : generic,
+    indications: indications || null,
+    dosage: dosage || null,
+    contraindications: contraindications || null,
+    warnings: warnings || null,
+    adverse: adverse || null,
+    updated: formatFdaDate(r.effective_time),
+    sourceUrl: setId ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}` : "https://dailymed.nlm.nih.gov/dailymed/",
+    sourceLabel: "DailyMed (U.S. National Library of Medicine)"
+  };
+}
+function score(r, q) {
+  const g = (r.openfda?.generic_name ?? []).join(", ").toLowerCase();
+  let s = 0;
+  if (g && g.split(/,| and /).length === 1) s += 2;
+  if (g.includes(q.toLowerCase())) s += 1;
+  return s;
+}
+async function searchEmc(drug) {
+  const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;
+  const res = await timedFetch(url);
+  if (!res.ok) return [];
+  const html = await res.text();
+  const $ = cheerio.load(html);
+  const out = [];
+  $("a[href*='/emc/product/']").each((_, el) => {
+    const href = $(el).attr("href") || "";
+    const m = href.match(/\/emc\/product\/(\d+)\/smpc/);
+    if (!m) return;
+    const name = $(el).text().trim();
+    if (!name || name.toLowerCase().includes("health professional")) return;
+    if (out.some((x) => x.product_id === m[1])) return;
+    out.push({ product_id: m[1], name });
+  });
+  return out;
+}
+var SMPC_WANT = {
+  "4.1": "indications",
+  "4.2": "dosage",
+  "4.3": "contraindications",
+  "4.4": "warnings",
+  "4.8": "adverse"
+};
+var SMPC_SECTION_NAMES = {
+  "4.1": "Therapeutic indications",
+  "4.2": "Posology and method of administration",
+  "4.3": "Contraindications",
+  "4.4": "Special warnings and precautions for use",
+  "4.5": "Interaction with other medicinal products",
+  "4.6": "Fertility, pregnancy and lactation",
+  "4.7": "Effects on ability to drive and use machines",
+  "4.8": "Undesirable effects",
+  "4.9": "Overdose",
+  "5.1": "Pharmacodynamic properties",
+  "5.2": "Pharmacokinetic properties",
+  "5.3": "Preclinical safety data"
+};
+function htmlToText(html) {
+  const $ = cheerio.load(html);
+  $("br").replaceWith("\n");
+  $("li").each((_, el) => {
+    $(el).prepend("- ");
+    $(el).append("\n");
+  });
+  $("p, div, tr, h1, h2, h3, h4, h5, h6").each((_, el) => {
+    $(el).append("\n");
+  });
+  return $.text().replace(/\n{3,}/g, "\n\n").trim();
+}
+function parseSmpcSections(html) {
+  const $ = cheerio.load(html);
+  const sectionElements = [];
+  $("[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4").each((_, el) => {
+    const text = $(el).text().trim();
+    const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+    if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });
+  });
+  if (sectionElements.length === 0) {
+    $("*").each((_, el) => {
+      const $el = $(el);
+      if ($el.children().length > 0 && !$el.is("a, span, strong, em, b, i")) return;
+      const text = $el.text().trim();
+      const match = text.match(/^(\d+\.?\d*)\s+(.+)/);
+      if (match && SMPC_SECTION_NAMES[match[1]]) {
+        sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });
+      }
+    });
+  }
+  const fields = {};
+  for (let i = 0; i < sectionElements.length; i++) {
+    const current = sectionElements[i];
+    const field = SMPC_WANT[current.code];
+    if (!field) continue;
+    const next = sectionElements[i + 1];
+    let content = "";
+    let node = current.element.next();
+    while (node.length > 0) {
+      if (next && node.is(next.element)) break;
+      const nodeHtml = $.html(node);
+      if (nodeHtml) content += htmlToText(nodeHtml) + "\n";
+      node = node.next();
+    }
+    if (!content.trim()) {
+      const parentHtml = $.html(current.element.parent());
+      if (parentHtml) {
+        content = htmlToText(parentHtml).replace(current.element.text().trim(), "").trim();
+      }
+    }
+    fields[field] = cleanSection(content);
+  }
+  return fields;
+}
+async function getSmpc(drug) {
+  if (!drug) return null;
+  try {
+    const matches = await searchEmc(drug);
+    if (matches.length === 0) return null;
+    const q = drug.toLowerCase();
+    matches.sort(
+      (a, b) => (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)
+    );
+    const best = matches[0];
+    const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);
+    if (!res.ok) return null;
+    const html = await res.text();
+    const sec = parseSmpcSections(html);
+    if (!sec.dosage && !sec.warnings && !sec.adverse && !sec.indications && !sec.contraindications)
+      return null;
+    return {
+      region: "UK/EU",
+      authority: "Summary of Product Characteristics (SmPC)",
+      productName: best.name,
+      indications: sec.indications || null,
+      dosage: sec.dosage || null,
+      contraindications: sec.contraindications || null,
+      warnings: sec.warnings || null,
+      adverse: sec.adverse || null,
+      updated: "",
+      sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,
+      sourceLabel: "electronic medicines compendium (emc), UK"
+    };
+  } catch {
+    return null;
+  }
+}
+async function getLabels(drug) {
+  const [us, uk] = await Promise.all([
+    getUspi(drug).catch(() => null),
+    getSmpc(drug).catch(() => null)
+  ]);
+  return { us, uk };
+}
+// src/compare.ts
+var SECTION_MAP = [
+  { topic: "Indications", field: "indications" },
+  { topic: "Dosing", field: "dosage" },
+  { topic: "Contraindications", field: "contraindications" },
+  { topic: "Warnings", field: "warnings" },
+  { topic: "Adverse Reactions", field: "adverse" }
+];
+async function compareLabels(drug) {
+  const { us, uk } = await getLabels(drug);
+  const comparisons = SECTION_MAP.map(({ topic, field }) => ({
+    topic,
+    us: us ? us[field] : null,
+    uk: uk ? uk[field] : null
+  })).filter((c) => c.us || c.uk);
+  return {
+    drug,
+    comparisons,
+    usSource: us?.sourceUrl ?? null,
+    ukSource: uk?.sourceUrl ?? null
+  };
+}
+export {
+  SECTION_MAP,
+  cleanSection,
+  compareLabels,
+  formatFdaDate,
+  getLabels,
+  getSmpc,
+  getUspi,
+  resolveName
+};
+//# sourceMappingURL=index.js.map

package/dist/index.js.map ADDED Viewed

@@ -0,0 +1 @@

+ {"version":3,"sources":["../src/fetch.ts","../src/names.ts","../src/labels.ts","../src/compare.ts"],"sourcesContent":["/**\n * Shared HTTP + text helpers. Uses the runtime's global `fetch` (Node >=18),\n * so the package has no node-fetch dependency.\n */\n\nconst DEFAULT_TIMEOUT_MS = 12000;\nconst MAX_FIELD_CHARS = 1400;\n\nexport const USER_AGENT = \"drug-data/0.1 (pharmatools.ai; nick@pharmatools.ai)\";\n\nexport async function timedFetch(\n url: string,\n opts: RequestInit = {},\n timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<Response> {\n const controller = new AbortController();\n const timer = setTimeout(() => controller.abort(), timeoutMs);\n try {\n return await fetch(url, {\n ...opts,\n signal: controller.signal,\n headers: { \"User-Agent\": USER_AGENT, ...((opts.headers as Record<string, string>) || {}) },\n });\n } finally {\n clearTimeout(timer);\n }\n}\n\nexport async function getJson<T = unknown>(\n url: string,\n timeoutMs = DEFAULT_TIMEOUT_MS\n): Promise<T | null> {\n try {\n const res = await timedFetch(url, {}, timeoutMs);\n if (!res.ok) return null;\n return (await res.json()) as T;\n } catch {\n return null;\n }\n}\n\n/**\n * Tidy a raw label section: join arrays, strip a leading numbered ALL-CAPS\n * heading, collapse whitespace, and truncate on a sentence boundary.\n */\nexport function cleanSection(value: unknown, maxChars = MAX_FIELD_CHARS): string {\n if (!value) return \"\";\n let text = Array.isArray(value) ? value.join(\"\\n\\n\") : String(value);\n\n text = text\n .replace(/\\r/g, \"\")\n .replace(/[ \\t]+/g, \" \")\n .replace(/\\n{3,}/g, \"\\n\\n\")\n .trim();\n\n // Drop a leading section header line like \"5 WARNINGS AND PRECAUTIONS\"\n text = text.replace(/^\\s*\\d+(\\.\\d+)*\\s+[A-Z][A-Z \\-/,&]+\\n+/, \"\").trim();\n\n if (text.length > maxChars) {\n const slice = text.slice(0, maxChars);\n const lastStop = Math.max(slice.lastIndexOf(\". \"), slice.lastIndexOf(\"\\n\"));\n text = (lastStop > maxChars * 0.6 ? slice.slice(0, lastStop + 1) : slice).trim() + \" …\";\n }\n return text;\n}\n\nexport function formatFdaDate(yyyymmdd?: string): string {\n if (!yyyymmdd || !/^\\d{8}$/.test(yyyymmdd)) return \"\";\n const d = new Date(`${yyyymmdd.slice(0, 4)}-${yyyymmdd.slice(4, 6)}-${yyyymmdd.slice(6, 8)}`);\n if (isNaN(d.getTime())) return \"\";\n return d.toLocaleDateString(\"en-US\", { year: \"numeric\", month: \"short\", day: \"numeric\" });\n}\n\nexport function titleCase(s: string): string {\n return String(s || \"\").replace(/\\w\\S*/g, (t) => t.charAt(0).toUpperCase() + t.slice(1).toLowerCase());\n}\n\nexport function uniq<T>(arr: T[]): T[] {\n return [...new Set(arr.filter(Boolean))];\n}\n","/**\n * Deterministic brand <-> generic resolution via RxNorm/RxNav, with an openFDA\n * fallback. No AI, no hallucinated names. Brand names are US-registered;\n * international brand names are intentionally not invented.\n */\n\nimport { getJson, titleCase, uniq } from \"./fetch.js\";\nimport type { ResolveResult } from \"./types.js\";\n\nconst RXNAV = \"https://rxnav.nlm.nih.gov/REST\";\nconst OPENFDA = \"https://api.fda.gov/drug/label.json\";\nconst TIMEOUT_MS = 10000;\n\nconst REGION_NOTE = \"Brand names shown are those registered in the United States.\";\n\n/* ----------------------- RxNorm resolution ----------------------- */\n\nasync function findRxcui(name: string): Promise<string | null> {\n const exact = await getJson<any>(`${RXNAV}/rxcui.json?name=${encodeURIComponent(name)}`, TIMEOUT_MS);\n const id = exact?.idGroup?.rxnormId?.[0];\n if (id) return id;\n\n const approx = await getJson<any>(\n `${RXNAV}/approximateTerm.json?term=${encodeURIComponent(name)}&maxEntries=1`,\n TIMEOUT_MS\n );\n const cand = approx?.approximateGroup?.candidate?.[0];\n return cand ? cand.rxcui : null;\n}\n\nfunction collectNames(allRelated: any, tty: string): string[] {\n const groups = allRelated?.allRelatedGroup?.conceptGroup ?? [];\n const g = groups.find((x: any) => x.tty === tty);\n if (!g || !g.conceptProperties) return [];\n return g.conceptProperties.map((c: any) => c.name);\n}\n\n/**\n * Single-ingredient brand names for a generic ingredient, via SBDF concepts\n * whose name is \"<ingredient> <dose form> [Brand]\". Combination products read\n * \"<ing A> / <ing B> ... [Brand]\", so any \"/\" before the bracket is excluded.\n */\nasync function getSingleIngredientBrands(ingredientRxcui: string): Promise<string[]> {\n const data = await getJson<any>(`${RXNAV}/rxcui/${ingredientRxcui}/related.json?tty=SBDF`, TIMEOUT_MS);\n const groups = data?.relatedGroup?.conceptGroup ?? [];\n const g = groups.find((x: any) => x.tty === \"SBDF\");\n if (!g || !g.conceptProperties) return [];\n const brands: string[] = [];\n for (const c of g.conceptProperties) {\n const m = (c.name as string).match(/\\[([^\\]]+)\\]\\s*$/);\n if (!m) continue;\n const prefix = (c.name as string).slice(0, (c.name as string).lastIndexOf(\"[\"));\n if (prefix.includes(\"/\")) continue; // combination product — skip\n brands.push(m[1].trim());\n }\n return uniq(brands).sort();\n}\n\nasync function getDrugClassAndUses(\n rxcui: string\n): Promise<{ drugClass: string | null; uses: string[] }> {\n const data = await getJson<any>(\n `${RXNAV}/rxclass/class/byRxcui.json?rxcui=${rxcui}&relaSource=MEDRT`,\n TIMEOUT_MS\n );\n const items = data?.rxclassDrugInfoList?.rxclassDrugInfo ?? [];\n\n const byType = (t: string): string | null => {\n const hit = items.find((i: any) => i.rxclassMinConceptItem.classType === t);\n return hit ? hit.rxclassMinConceptItem.className : null;\n };\n // Prefer FDA Established Pharmacologic Class, then mechanism, then chemical.\n const drugClass = byType(\"EPC\") || byType(\"MOA\") || byType(\"CHEM\");\n\n const uses = uniq<string>(\n items\n .filter((i: any) => i.rela === \"may_treat\")\n .map((i: any) => i.rxclassMinConceptItem.className as string)\n ).slice(0, 6);\n\n return { drugClass, uses };\n}\n\nasync function resolveViaRxNorm(name: string): Promise<ResolveResult | null> {\n const rxcui = await findRxcui(name);\n if (!rxcui) return null;\n\n const [props, allRelated] = await Promise.all([\n getJson<any>(`${RXNAV}/rxcui/${rxcui}/properties.json`, TIMEOUT_MS),\n getJson<any>(`${RXNAV}/rxcui/${rxcui}/allrelated.json`, TIMEOUT_MS),\n ]);\n\n const tty: string | undefined = props?.properties?.tty;\n const canonicalName: string = props?.properties?.name ?? name;\n if (!tty) return null;\n\n const inNames = collectNames(allRelated, \"IN\");\n const minNames = collectNames(allRelated, \"MIN\");\n\n const isBrand = tty === \"BN\" || tty === \"SBD\" || tty === \"BPCK\";\n const inputType: \"brand\" | \"generic\" = isBrand ? \"brand\" : \"generic\";\n\n // For a generic, list only brands where it is the sole active ingredient.\n let brandNames: string[] | null = null;\n if (!isBrand) {\n const single = await getSingleIngredientBrands(rxcui);\n const fallback = uniq([...collectNames(allRelated, \"BN\"), ...collectNames(allRelated, \"BPCK\")]).sort();\n brandNames = single.length ? single : fallback;\n }\n\n // Generic display name: prefer the canonical combo string, else single, else joined.\n let genericName: string | null = null;\n if (minNames.length) genericName = titleCase(minNames[0]);\n else if (inNames.length === 1) genericName = titleCase(inNames[0]);\n else if (inNames.length > 1) genericName = titleCase(uniq(inNames).join(\" / \"));\n\n // Class + indications from the ingredient rxcui where possible.\n const classRxcui = !isBrand\n ? rxcui\n : (() => {\n const inGroup = (allRelated?.allRelatedGroup?.conceptGroup ?? []).find((x: any) => x.tty === \"IN\");\n return inGroup?.conceptProperties?.[0]?.rxcui ?? rxcui;\n })();\n const { drugClass, uses } = await getDrugClassAndUses(classRxcui);\n\n return {\n inputType,\n inputName: titleCase(canonicalName),\n genericName,\n brandNames,\n drugClass,\n uses,\n rxcui,\n source: \"RxNorm (NLM)\",\n regionNote: REGION_NOTE,\n };\n}\n\n/* ----------------------- openFDA fallback ------------------------ */\n\nasync function resolveViaOpenFda(name: string): Promise<ResolveResult | null> {\n const q = name.replace(/\"/g, \"\");\n const search = `(openfda.brand_name:\"${q}\"+OR+openfda.generic_name:\"${q}\")`;\n const url = `${OPENFDA}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&limit=1`;\n const data = await getJson<any>(url, TIMEOUT_MS);\n const fda = data?.results?.[0]?.openfda;\n if (!fda) return null;\n\n const brand = (fda.brand_name ?? [])[0] ?? \"\";\n const generic = (fda.generic_name ?? [])[0] ?? \"\";\n if (!brand && !generic) return null;\n\n const isBrand = brand.toLowerCase() === name.toLowerCase();\n return {\n inputType: isBrand ? \"brand\" : \"generic\",\n inputName: titleCase(name),\n genericName: generic ? titleCase(generic) : null,\n brandNames: isBrand ? null : uniq<string>(fda.brand_name ?? []).sort(),\n drugClass: (fda.pharm_class_epc ?? [])[0] ?? (fda.pharm_class_moa ?? [])[0] ?? null,\n uses: [],\n rxcui: null,\n source: \"openFDA\",\n regionNote: REGION_NOTE,\n };\n}\n\n/* --------------------------- public ----------------------------- */\n\n/**\n * Resolve a drug name deterministically. Tries RxNorm, then openFDA. Returns\n * null if neither source recognises the name.\n */\nexport async function resolveName(name: string): Promise<ResolveResult | null> {\n if (!name || !name.trim()) return null;\n const clean = name.trim();\n const viaRx = await resolveViaRxNorm(clean).catch(() => null);\n if (viaRx && (viaRx.genericName || (viaRx.brandNames && viaRx.brandNames.length))) {\n return viaRx;\n }\n return await resolveViaOpenFda(clean).catch(() => null);\n}\n","/**\n * Official drug-label lookups.\n * - US: FDA label via the openFDA API -> DailyMed citation\n * - UK/EU: SmPC via the eMC (medicines.org.uk) -> eMC citation\n *\n * Every network call is best-effort: any failure returns null so callers never\n * break. Pure fetch + parse — caching belongs to the consumer.\n */\n\nimport * as cheerio from \"cheerio\";\nimport { timedFetch, getJson, cleanSection, formatFdaDate } from \"./fetch.js\";\nimport type { RegionLabel, LabelResult } from \"./types.js\";\n\nconst OPENFDA_URL = \"https://api.fda.gov/drug/label.json\";\nconst EMC_BASE = \"https://www.medicines.org.uk\";\n\ninterface OpenFdaLabel {\n effective_time?: string;\n dosage_and_administration?: string[];\n boxed_warning?: string[];\n warnings_and_cautions?: string[];\n warnings?: string[];\n adverse_reactions?: string[];\n indications_and_usage?: string[];\n contraindications?: string[];\n openfda?: {\n generic_name?: string[];\n brand_name?: string[];\n spl_set_id?: string[];\n };\n}\ninterface OpenFdaResponse {\n results?: OpenFdaLabel[];\n}\n\n/* --------------------------- US: openFDA --------------------------- */\n\nexport async function getUspi(drug: string): Promise<RegionLabel | null> {\n if (!drug) return null;\n const q = drug.trim().replace(/\"/g, \"\");\n const search = `(openfda.generic_name:\"${q}\"+OR+openfda.brand_name:\"${q}\")`;\n const url = `${OPENFDA_URL}?search=${encodeURIComponent(search).replace(/%2B/g, \"+\")}&sort=effective_time:desc&limit=5`;\n\n const data = await getJson<OpenFdaResponse>(url);\n const results = data?.results ?? [];\n if (results.length === 0) return null;\n\n // Prefer a single-ingredient product over combination labels.\n const ranked = results.slice().sort((a, b) => score(b, q) - score(a, q));\n const r = ranked[0];\n\n const dosage = cleanSection(r.dosage_and_administration);\n const boxed = cleanSection(r.boxed_warning);\n const warn = cleanSection(r.warnings_and_cautions ?? r.warnings);\n const warnings = [boxed ? `BOXED WARNING — ${boxed}` : \"\", warn].filter(Boolean).join(\"\\n\\n\");\n const adverse = cleanSection(r.adverse_reactions);\n const indications = cleanSection(r.indications_and_usage);\n const contraindications = cleanSection(r.contraindications);\n\n if (!dosage && !warnings && !adverse && !indications && !contraindications) return null;\n\n const setId = r.openfda?.spl_set_id?.[0] ?? \"\";\n const brand = r.openfda?.brand_name?.[0] ?? \"\";\n const generic = r.openfda?.generic_name?.[0] ?? q;\n\n return {\n region: \"US\",\n authority: \"FDA Prescribing Information\",\n productName: brand ? `${brand} (${generic})` : generic,\n indications: indications || null,\n dosage: dosage || null,\n contraindications: contraindications || null,\n warnings: warnings || null,\n adverse: adverse || null,\n updated: formatFdaDate(r.effective_time),\n sourceUrl: setId\n ? `https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=${setId}`\n : \"https://dailymed.nlm.nih.gov/dailymed/\",\n sourceLabel: \"DailyMed (U.S. National Library of Medicine)\",\n };\n}\n\nfunction score(r: OpenFdaLabel, q: string): number {\n const g = (r.openfda?.generic_name ?? []).join(\", \").toLowerCase();\n let s = 0;\n if (g && g.split(/,| and /).length === 1) s += 2; // single ingredient\n if (g.includes(q.toLowerCase())) s += 1;\n return s;\n}\n\n/* --------------------------- UK/EU: eMC ---------------------------- */\n\ninterface EmcMatch {\n product_id: string;\n name: string;\n}\n\nasync function searchEmc(drug: string): Promise<EmcMatch[]> {\n const url = `${EMC_BASE}/emc/search?${new URLSearchParams({ q: drug })}`;\n const res = await timedFetch(url);\n if (!res.ok) return [];\n const html = await res.text();\n const $ = cheerio.load(html);\n const out: EmcMatch[] = [];\n $(\"a[href*='/emc/product/']\").each((_, el) => {\n const href = $(el).attr(\"href\") || \"\";\n const m = href.match(/\\/emc\\/product\\/(\\d+)\\/smpc/);\n if (!m) return;\n const name = $(el).text().trim();\n if (!name || name.toLowerCase().includes(\"health professional\")) return;\n if (out.some((x) => x.product_id === m[1])) return;\n out.push({ product_id: m[1], name });\n });\n return out;\n}\n\n// SmPC section number -> the field we store it under\nconst SMPC_WANT: Record<string, keyof Pick<RegionLabel, \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\">> = {\n \"4.1\": \"indications\",\n \"4.2\": \"dosage\",\n \"4.3\": \"contraindications\",\n \"4.4\": \"warnings\",\n \"4.8\": \"adverse\",\n};\n\n// Canonical SmPC section titles — used as a fallback heading detector\nconst SMPC_SECTION_NAMES: Record<string, string> = {\n \"4.1\": \"Therapeutic indications\",\n \"4.2\": \"Posology and method of administration\",\n \"4.3\": \"Contraindications\",\n \"4.4\": \"Special warnings and precautions for use\",\n \"4.5\": \"Interaction with other medicinal products\",\n \"4.6\": \"Fertility, pregnancy and lactation\",\n \"4.7\": \"Effects on ability to drive and use machines\",\n \"4.8\": \"Undesirable effects\",\n \"4.9\": \"Overdose\",\n \"5.1\": \"Pharmacodynamic properties\",\n \"5.2\": \"Pharmacokinetic properties\",\n \"5.3\": \"Preclinical safety data\",\n};\n\nfunction htmlToText(html: string): string {\n const $ = cheerio.load(html);\n $(\"br\").replaceWith(\"\\n\");\n $(\"li\").each((_, el) => {\n $(el).prepend(\"- \");\n $(el).append(\"\\n\");\n });\n $(\"p, div, tr, h1, h2, h3, h4, h5, h6\").each((_, el) => {\n $(el).append(\"\\n\");\n });\n return $.text().replace(/\\n{3,}/g, \"\\n\\n\").trim();\n}\n\n/**\n * Parse the wanted SmPC sections from eMC HTML. Detect numbered headings, then\n * collect sibling content up to the next heading, with a parent-text fallback.\n */\nfunction parseSmpcSections(html: string): Record<string, string> {\n const $ = cheerio.load(html);\n const sectionElements: Array<{ code: string; title: string; element: any }> = [];\n\n // Strategy 1: headings whose text starts with a section number\n $(\"[id*='SECTION'], [id*='section'], .sectionHeading, h2, h3, h4\").each((_, el) => {\n const text = $(el).text().trim();\n const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n if (match) sectionElements.push({ code: match[1], title: match[2].trim(), element: $(el) });\n });\n\n // Strategy 2: fall back to scanning leaf nodes for known section headers\n if (sectionElements.length === 0) {\n $(\"*\").each((_, el) => {\n const $el = $(el);\n if ($el.children().length > 0 && !$el.is(\"a, span, strong, em, b, i\")) return;\n const text = $el.text().trim();\n const match = text.match(/^(\\d+\\.?\\d*)\\s+(.+)/);\n if (match && SMPC_SECTION_NAMES[match[1]]) {\n sectionElements.push({ code: match[1], title: match[2].trim(), element: $el });\n }\n });\n }\n\n const fields: Record<string, string> = {};\n for (let i = 0; i < sectionElements.length; i++) {\n const current = sectionElements[i];\n const field = SMPC_WANT[current.code];\n if (!field) continue;\n const next = sectionElements[i + 1];\n\n let content = \"\";\n let node = current.element.next();\n while (node.length > 0) {\n if (next && node.is(next.element)) break;\n const nodeHtml = $.html(node);\n if (nodeHtml) content += htmlToText(nodeHtml) + \"\\n\";\n node = node.next();\n }\n\n if (!content.trim()) {\n const parentHtml = $.html(current.element.parent());\n if (parentHtml) {\n content = htmlToText(parentHtml).replace(current.element.text().trim(), \"\").trim();\n }\n }\n\n fields[field] = cleanSection(content);\n }\n return fields;\n}\n\nexport async function getSmpc(drug: string): Promise<RegionLabel | null> {\n if (!drug) return null;\n try {\n const matches = await searchEmc(drug);\n if (matches.length === 0) return null;\n\n const q = drug.toLowerCase();\n matches.sort(\n (a, b) =>\n (b.name.toLowerCase().includes(q) ? 1 : 0) - (a.name.toLowerCase().includes(q) ? 1 : 0)\n );\n const best = matches[0];\n\n const res = await timedFetch(`${EMC_BASE}/emc/product/${best.product_id}/smpc`);\n if (!res.ok) return null;\n const html = await res.text();\n const sec = parseSmpcSections(html);\n\n if (!sec.dosage && !sec.warnings && !sec.adverse && !sec.indications && !sec.contraindications)\n return null;\n\n return {\n region: \"UK/EU\",\n authority: \"Summary of Product Characteristics (SmPC)\",\n productName: best.name,\n indications: sec.indications || null,\n dosage: sec.dosage || null,\n contraindications: sec.contraindications || null,\n warnings: sec.warnings || null,\n adverse: sec.adverse || null,\n updated: \"\",\n sourceUrl: `${EMC_BASE}/emc/product/${best.product_id}/smpc`,\n sourceLabel: \"electronic medicines compendium (emc), UK\",\n };\n } catch {\n return null;\n }\n}\n\n/* --------------------------- public API ---------------------------- */\n\n/** Look up both labels for a drug. Each side is null if unavailable. Never throws. */\nexport async function getLabels(drug: string): Promise<LabelResult> {\n const [us, uk] = await Promise.all([\n getUspi(drug).catch(() => null),\n getSmpc(drug).catch(() => null),\n ]);\n return { us, uk };\n}\n","/**\n * US (FDA) vs UK/EU (SmPC) side-by-side label comparison across mapped topics.\n */\n\nimport { getLabels } from \"./labels.js\";\nimport type { CompareResult, LabelComparison } from \"./types.js\";\n\ntype LabelField = \"indications\" | \"dosage\" | \"contraindications\" | \"warnings\" | \"adverse\";\n\n/** Topics compared across US and UK labels, mapped to the fields that hold them. */\nexport const SECTION_MAP: Array<{ topic: string; field: LabelField }> = [\n { topic: \"Indications\", field: \"indications\" },\n { topic: \"Dosing\", field: \"dosage\" },\n { topic: \"Contraindications\", field: \"contraindications\" },\n { topic: \"Warnings\", field: \"warnings\" },\n { topic: \"Adverse Reactions\", field: \"adverse\" },\n];\n\nexport async function compareLabels(drug: string): Promise<CompareResult> {\n const { us, uk } = await getLabels(drug);\n\n const comparisons: LabelComparison[] = SECTION_MAP.map(({ topic, field }) => ({\n topic,\n us: us ? us[field] : null,\n uk: uk ? uk[field] : null,\n })).filter((c) => c.us || c.uk);\n\n return {\n drug,\n comparisons,\n usSource: us?.sourceUrl ?? null,\n ukSource: uk?.sourceUrl ?? null,\n 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package/package.json ADDED Viewed

@@ -0,0 +1,51 @@
+{
+  "name": "@pharmatools/drug-data",
+  "version": "0.1.0",
+  "description": "Deterministic drug-name resolution (RxNorm) and official label data (FDA openFDA + UK eMC SmPC), with US/UK comparison. The shared engine behind Pharmonym and PubCrawl.",
+  "type": "module",
+  "exports": {
+    ".": {
+      "types": "./dist/index.d.ts",
+      "import": "./dist/index.js",
+      "require": "./dist/index.cjs"
+    }
+  },
+  "main": "./dist/index.cjs",
+  "module": "./dist/index.js",
+  "types": "./dist/index.d.ts",
+  "files": [
+    "dist"
+  ],
+  "engines": {
+    "node": ">=18"
+  },
+  "scripts": {
+    "build": "tsup",
+    "test": "vitest run",
+    "typecheck": "tsc --noEmit",
+    "prepublishOnly": "npm run build && npm test"
+  },
+  "keywords": [
+    "pharma",
+    "drug-names",
+    "rxnorm",
+    "openfda",
+    "fda",
+    "smpc",
+    "dailymed",
+    "drug-labels"
+  ],
+  "author": "PharmaTools.AI",
+  "license": "MIT",
+  "dependencies": {
+    "cheerio": "^1.0.0"
+  },
+  "devDependencies": {
+    "tsup": "^8.0.0",
+    "typescript": "^5.4.0",
+    "vitest": "^2.0.0"
+  },
+  "publishConfig": {
+    "access": "public"
+  }
+}