@morscherlab/mint-sdk 1.2.0-beta.3 → 1.2.0-beta.4

package/src/templates/qpcrExpressionCollectionBuilder.ts

@@ -0,0 +1,33 @@
+import { createQpcrPlateTemplate } from './qpcrPlateBuilder'
+import { createSampleSheetTemplate } from './sampleSheetBuilder'
+import { presetSampleRecords } from './sampleNormalizers'
+import { createTemplateCollection } from './templateEnvelopes'
+import type {
+  CreateQpcrExpressionCollectionOptions,
+  TemplateCollectionEnvelope,
+} from './types'
+
+export function createQpcrExpressionCollection(
+  options: CreateQpcrExpressionCollectionOptions = {}
+): TemplateCollectionEnvelope {
+  const sampleRecords = presetSampleRecords(options.samples ?? ['Control', 'Treatment'])
+  const sampleSheet = createSampleSheetTemplate({ samples: sampleRecords })
+  const qpcr = createQpcrPlateTemplate({
+    samples: sampleRecords.map(sample => ({
+      sampleId: sample.sampleId,
+      name: sample.name,
+      group: sample.group,
+      metadata: sample.metadata ?? {},
+    })),
+    targets: options.targets ?? ['ACTB', 'GAPDH'],
+    chemistry: options.chemistry,
+    format: options.format,
+    includeNoTemplateControls: options.includeNoTemplateControls,
+    replicates: options.replicates ?? 3,
+    instrument: options.instrument,
+  })
+  return createTemplateCollection(
+    [sampleSheet, qpcr],
+    { preset: 'qpcr-expression', ...(options.metadata ?? {}) }
+  )
+}

package/src/templates/qpcrPlateBuilder.ts

@@ -0,0 +1,96 @@
+import { idFromName } from './builderIdUtils'
+import { wellIdsForFormat } from './plateGeometry'
+import {
+  normalizeQpcrSample,
+  normalizeQpcrTarget,
+} from './runNormalizers'
+import { createTemplateEnvelope } from './templateEnvelopes'
+import { validateQpcrPlateData } from './templateValidators'
+import type {
+  CreateQpcrPlateTemplateOptions,
+  QpcrPlateTemplate,
+  QpcrPlateTemplateData,
+  QpcrReaction,
+  QpcrSample,
+  QpcrTarget,
+} from './types'
+
+export function createQpcrPlateTemplate(
+  options: CreateQpcrPlateTemplateOptions
+): QpcrPlateTemplate {
+  const format = options.format ?? 96
+  const replicates = options.replicates ?? 3
+  if (replicates < 1) {
+    throw new Error('qPCR replicates must be at least 1.')
+  }
+
+  const samples = options.samples.map((sample, index): QpcrSample => {
+    if (typeof sample !== 'string') return normalizeQpcrSample(sample)
+    return {
+      sampleId: idFromName(sample, `sample-${index + 1}`),
+      name: sample,
+      metadata: {},
+    }
+  })
+  const targets = options.targets.map((target, index): QpcrTarget => {
+    if (typeof target !== 'string') return normalizeQpcrTarget(target)
+    return {
+      id: idFromName(target, `target-${index + 1}`),
+      name: target,
+      metadata: {},
+    }
+  })
+  const wells = wellIdsForFormat(format)
+  let wellIndex = 0
+  const reactions: QpcrReaction[] = []
+
+  for (const sample of samples) {
+    for (const target of targets) {
+      for (let replicate = 1; replicate <= replicates; replicate += 1) {
+        const wellId = wells[wellIndex]
+        if (!wellId) throw new Error(`qPCR plate format ${format} does not have enough wells.`)
+        reactions.push({
+          id: `${sample.sampleId}-${target.id}-r${replicate}`,
+          wellId,
+          sampleId: sample.sampleId,
+          targetId: target.id,
+          replicate,
+          controlKind: 'sample',
+          flags: [],
+          metadata: {},
+        })
+        wellIndex += 1
+      }
+    }
+  }
+
+  if (options.includeNoTemplateControls !== false) {
+    for (const target of targets) {
+      const wellId = wells[wellIndex]
+      if (!wellId) throw new Error(`qPCR plate format ${format} does not have enough wells.`)
+      reactions.push({
+        id: `ntc-${target.id}`,
+        wellId,
+        targetId: target.id,
+        replicate: 1,
+        controlKind: 'no-template',
+        flags: [],
+        metadata: {},
+      })
+      wellIndex += 1
+    }
+  }
+
+  const data: QpcrPlateTemplateData = {
+    plateId: 'qpcr-plate-1',
+    format,
+    samples,
+    targets,
+    reactions,
+    instrument: options.instrument,
+    chemistry: options.chemistry ?? 'sybr',
+    metadata: options.metadata ?? {},
+  }
+  validateQpcrPlateData(data)
+  return createTemplateEnvelope('qpcr-plate', data, options.metadata ?? {})
+}

package/src/templates/reagentAdapters.ts

@@ -0,0 +1,77 @@
+import { getTemplateData } from './templateEnvelopes'
+import { validateReagentListData } from './templateValidators'
+import type {
+  ReagentColumnsAdapterResult,
+  ReagentDataFrameAdapterResult,
+  ReagentListItemsAdapterResult,
+  ReagentListTemplate,
+  ReagentListTemplateData,
+  ReagentRowsAdapterResult,
+} from './types'
+
+export function toReagentListItems(
+  template: ReagentListTemplate | ReagentListTemplateData
+): ReagentListItemsAdapterResult {
+  const data = getTemplateData(template, 'reagent-list')
+  validateReagentListData(data)
+  return data.reagents.map(reagent => ({
+    id: reagent.id,
+    name: reagent.name,
+    catalogNumber: reagent.catalogNumber,
+    lotNumber: reagent.lotNumber,
+    expiryDate: reagent.expiryDate,
+    storageCondition: reagent.storageCondition,
+    location: reagent.location,
+    stockLevel: reagent.stockLevel,
+    stockUnit: reagent.stockUnit,
+    supplier: reagent.supplier,
+    url: reagent.url,
+  }))
+}
+
+export function toReagentRows(
+  template: ReagentListTemplate | ReagentListTemplateData
+): ReagentRowsAdapterResult {
+  const data = getTemplateData(template, 'reagent-list')
+  validateReagentListData(data)
+  return data.reagents.map(reagent => ({
+    id: reagent.id,
+    name: reagent.name,
+    kind: reagent.kind,
+    catalogNumber: reagent.catalogNumber,
+    lotNumber: reagent.lotNumber,
+    expiryDate: reagent.expiryDate,
+    storageCondition: reagent.storageCondition,
+    location: reagent.location,
+    stockLevel: reagent.stockLevel,
+    stockUnit: reagent.stockUnit,
+    supplier: reagent.supplier,
+    concentration: reagent.concentration,
+    ...(reagent.metadata ?? {}),
+  }))
+}
+
+export function toReagentColumns(): ReagentColumnsAdapterResult {
+  return [
+    { key: 'name', label: 'Name', sortable: true },
+    { key: 'kind', label: 'Kind', sortable: true },
+    { key: 'catalogNumber', label: 'Catalog', sortable: true },
+    { key: 'lotNumber', label: 'Lot', sortable: true },
+    { key: 'expiryDate', label: 'Expiry', sortable: true },
+    { key: 'storageCondition', label: 'Storage', sortable: true },
+    { key: 'location', label: 'Location', sortable: true },
+    { key: 'stockLevel', label: 'Stock', sortable: true, align: 'right' },
+    { key: 'stockUnit', label: 'Unit', sortable: true },
+    { key: 'supplier', label: 'Supplier', sortable: true },
+  ]
+}
+
+export function toReagentDataFrame(
+  template: ReagentListTemplate | ReagentListTemplateData
+): ReagentDataFrameAdapterResult {
+  return {
+    data: toReagentRows(template),
+    columns: toReagentColumns(),
+    rowKey: 'id',
+  }
+}

package/src/templates/reagentListBuilder.ts

@@ -0,0 +1,30 @@
+import { normalizeReagent } from './assayNormalizers'
+import { idFromName } from './builderIdUtils'
+import { createTemplateEnvelope } from './templateEnvelopes'
+import { validateReagentListData } from './templateValidators'
+import type {
+  CreateReagentListTemplateOptions,
+  ReagentListTemplate,
+  ReagentListTemplateData,
+  ReagentRecord,
+} from './types'
+
+export function createReagentListTemplate(
+  options: CreateReagentListTemplateOptions
+): ReagentListTemplate {
+  const reagents = options.reagents.map((reagent, index): ReagentRecord => {
+    if (typeof reagent !== 'string') return normalizeReagent(reagent)
+    return {
+      id: idFromName(reagent, `reagent-${index + 1}`),
+      name: reagent,
+      kind: 'reagent',
+      metadata: {},
+    }
+  })
+  const data: ReagentListTemplateData = {
+    reagents,
+    metadata: options.metadata ?? {},
+  }
+  validateReagentListData(data)
+  return createTemplateEnvelope('reagent-list', data, options.metadata ?? {})
+}

package/src/templates/runNormalizers.ts

@@ -0,0 +1,63 @@
+import type {
+  InstrumentMethod,
+  InstrumentRunItem,
+  QpcrSample,
+  QpcrTarget,
+} from './types'
+import { idFromName } from './builderIdUtils'
+
+export function normalizeInstrumentMethod(
+  method: Partial<InstrumentMethod> & { name?: string },
+  fallbackInstrument?: string
+): InstrumentMethod {
+  const name = method.name || method.id || 'Default method'
+  return {
+    id: method.id || idFromName(name, 'method-1'),
+    name,
+    instrument: method.instrument ?? fallbackInstrument,
+    acquisitionMode: method.acquisitionMode,
+    metadata: method.metadata ?? {},
+  }
+}
+
+export function normalizeInstrumentRunItem(
+  item: Partial<InstrumentRunItem> & { name?: string; sampleId?: string },
+  defaultMethodId: string,
+  fallbackOrder: number,
+  index: number
+): InstrumentRunItem {
+  const kind = item.kind ?? 'sample'
+  const sampleId = item.sampleId || (kind === 'sample'
+    ? idFromName(item.name ?? `Sample ${index + 1}`, `sample-${index + 1}`)
+    : undefined)
+  const label = item.name ?? sampleId ?? kind
+  return {
+    id: item.id || idFromName(label, `${kind}-${index + 1}`),
+    order: item.order ?? fallbackOrder,
+    kind,
+    sampleId,
+    name: item.name,
+    methodId: item.methodId || defaultMethodId,
+    vial: item.vial,
+    plateId: item.plateId,
+    wellId: item.wellId,
+    injectionVolume: item.injectionVolume,
+    expectedDurationMin: item.expectedDurationMin,
+    status: item.status ?? 'planned',
+    metadata: item.metadata ?? {},
+  }
+}
+
+export function normalizeQpcrSample(sample: QpcrSample): QpcrSample {
+  return {
+    ...sample,
+    metadata: sample.metadata ?? {},
+  }
+}
+
+export function normalizeQpcrTarget(target: QpcrTarget): QpcrTarget {
+  return {
+    ...target,
+    metadata: target.metadata ?? {},
+  }
+}

package/src/templates/sampleNormalizers.ts

@@ -0,0 +1,58 @@
+import type {
+  SamplePrepStep,
+  SamplePrepStepInput,
+  SampleRecord,
+} from './types'
+import {
+  idFromName,
+  sampleIdFromName,
+} from './builderIdUtils'
+
+export function normalizeSampleRecord(sample: SampleRecord): SampleRecord {
+  return {
+    ...sample,
+    metadata: sample.metadata ?? {},
+  }
+}
+
+export function presetSampleRecords(samples: Array<string | SampleRecord>): SampleRecord[] {
+  return samples.map((sample, index) => {
+    if (typeof sample !== 'string') return normalizeSampleRecord(sample)
+    return {
+      sampleId: sampleIdFromName(sample, index),
+      name: sample,
+      metadata: {},
+    }
+  })
+}
+
+export function normalizeSamplePrepStep(
+  step: SamplePrepStepInput,
+  prepType: SamplePrepStep['type'],
+  volumeUnit: string,
+  order: number,
+  index: number
+): SamplePrepStep {
+  const type = step.type ?? prepType
+  const sourceSampleId = step.sourceSampleId
+  const name = step.name || `Prepare ${sourceSampleId ?? index + 1}`
+  return {
+    id: step.id || idFromName(name, `${type}-${index + 1}`),
+    order: step.order ?? order,
+    type,
+    name,
+    sourceSampleId,
+    sourcePlateId: step.sourcePlateId,
+    sourceWellId: step.sourceWellId,
+    destinationSampleId: step.destinationSampleId,
+    destinationPlateId: step.destinationPlateId,
+    destinationWellId: step.destinationWellId,
+    reagentId: step.reagentId,
+    inputVolume: step.inputVolume,
+    outputVolume: step.outputVolume,
+    volumeUnit: step.volumeUnit || volumeUnit,
+    durationMin: step.durationMin,
+    status: step.status ?? 'planned',
+    metadata: step.metadata ?? {},
+  }
+}

package/src/templates/samplePrepAdapters.ts

@@ -0,0 +1,63 @@
+import { getTemplateData } from './templateEnvelopes'
+import { validateSamplePrepData } from './templateValidators'
+import type {
+  SamplePrepColumnsAdapterResult,
+  SamplePrepDataFrameAdapterResult,
+  SamplePrepRowsAdapterResult,
+  SamplePrepTemplate,
+  SamplePrepTemplateData,
+} from './types'
+
+export function toSamplePrepRows(
+  template: SamplePrepTemplate | SamplePrepTemplateData
+): SamplePrepRowsAdapterResult {
+  const data = getTemplateData(template, 'sample-prep')
+  validateSamplePrepData(data)
+  return [...data.steps]
+    .sort((a, b) => a.order - b.order)
+    .map(step => ({
+      id: step.id,
+      order: step.order,
+      type: step.type,
+      name: step.name,
+      sourceSampleId: step.sourceSampleId,
+      sourceWellId: step.sourceWellId,
+      destinationSampleId: step.destinationSampleId,
+      destinationWellId: step.destinationWellId,
+      reagentId: step.reagentId,
+      inputVolume: step.inputVolume,
+      outputVolume: step.outputVolume,
+      volumeUnit: step.volumeUnit,
+      durationMin: step.durationMin,
+      status: step.status,
+      protocolName: data.protocolName,
+      ...(step.metadata ?? {}),
+    }))
+}
+
+export function toSamplePrepColumns(): SamplePrepColumnsAdapterResult {
+  return [
+    { key: 'order', label: 'Order', sortable: true, align: 'right' },
+    { key: 'type', label: 'Type', sortable: true },
+    { key: 'name', label: 'Step', sortable: true },
+    { key: 'sourceSampleId', label: 'Source', sortable: true },
+    { key: 'sourceWellId', label: 'Source well', sortable: true },
+    { key: 'destinationSampleId', label: 'Destination', sortable: true },
+    { key: 'destinationWellId', label: 'Destination well', sortable: true },
+    { key: 'reagentId', label: 'Reagent', sortable: true },
+    { key: 'inputVolume', label: 'Input', sortable: true, align: 'right' },
+    { key: 'outputVolume', label: 'Output', sortable: true, align: 'right' },
+    { key: 'volumeUnit', label: 'Unit', sortable: true },
+    { key: 'status', label: 'Status', sortable: true },
+  ]
+}
+
+export function toSamplePrepDataFrame(
+  template: SamplePrepTemplate | SamplePrepTemplateData
+): SamplePrepDataFrameAdapterResult {
+  return {
+    data: toSamplePrepRows(template),
+    columns: toSamplePrepColumns(),
+    rowKey: 'id',
+  }
+}

package/src/templates/samplePrepBuilder.ts

@@ -0,0 +1,51 @@
+import { idFromName } from './builderIdUtils'
+import { normalizeSamplePrepStep } from './sampleNormalizers'
+import { createTemplateEnvelope } from './templateEnvelopes'
+import { validateSamplePrepData } from './templateValidators'
+import type {
+  CreateSamplePrepTemplateOptions,
+  SamplePrepStep,
+  SamplePrepTemplate,
+  SamplePrepTemplateData,
+} from './types'
+
+export function createSamplePrepTemplate(
+  options: CreateSamplePrepTemplateOptions
+): SamplePrepTemplate {
+  const prepType = options.prepType ?? 'extraction'
+  const volumeUnit = options.volumeUnit ?? 'uL'
+  const steps: SamplePrepStep[] = []
+  let order = 1
+
+  for (const [index, sample] of options.samples.entries()) {
+    if (typeof sample !== 'string') {
+      const step = normalizeSamplePrepStep(sample, prepType, volumeUnit, order, index)
+      steps.push(step)
+      order = Math.max(order, step.order + 1)
+      continue
+    }
+    const sourceSampleId = idFromName(sample, `sample-${index + 1}`)
+    steps.push({
+      id: `${sourceSampleId}-prep`,
+      order,
+      type: prepType,
+      name: `Prepare ${sample}`,
+      sourceSampleId,
+      destinationSampleId: `${sourceSampleId}-prepared`,
+      inputVolume: options.inputVolume,
+      outputVolume: options.outputVolume,
+      volumeUnit,
+      status: 'planned',
+      metadata: {},
+    })
+    order += 1
+  }
+
+  const data: SamplePrepTemplateData = {
+    protocolName: options.protocolName ?? 'Sample preparation',
+    steps,
+    metadata: options.metadata ?? {},
+  }
+  validateSamplePrepData(data)
+  return createTemplateEnvelope('sample-prep', data, options.metadata ?? {})
+}

package/src/templates/sampleSheetAdapters.ts

@@ -0,0 +1,75 @@
+import type {
+  DataFrameColumn,
+  SelectOption,
+} from '../types'
+import { getTemplateData } from './templateEnvelopes'
+import { validateSampleSheetData } from './templateValidators'
+import type {
+  SampleColumnsAdapterResult,
+  SampleDataFrameAdapterResult,
+  SampleOptionsAdapterResult,
+  SampleRowsAdapterResult,
+  SampleSheetTemplate,
+  SampleSheetTemplateData,
+} from './types'
+
+export function toSampleRows(
+  template: SampleSheetTemplate | SampleSheetTemplateData
+): SampleRowsAdapterResult {
+  const data = getTemplateData(template, 'sample-sheet')
+  validateSampleSheetData(data)
+  return data.samples.map(sample => ({
+    sampleId: sample.sampleId,
+    name: sample.name,
+    group: sample.group,
+    batch: sample.batch,
+    replicate: sample.replicate,
+    plateId: sample.plateId,
+    wellId: sample.wellId,
+    ...(sample.metadata ?? {}),
+  }))
+}
+
+export function toSampleColumns(
+  template: SampleSheetTemplate | SampleSheetTemplateData
+): SampleColumnsAdapterResult {
+  const data = getTemplateData(template, 'sample-sheet')
+  validateSampleSheetData(data)
+  return data.columns.map((column): DataFrameColumn<Record<string, unknown>> => ({
+    key: sampleColumnKey(column.id),
+    label: column.label,
+    sortable: true,
+    align: column.type === 'number' || column.type === 'integer' ? 'right' : 'left',
+  }))
+}
+
+export function toSampleDataFrame(
+  template: SampleSheetTemplate | SampleSheetTemplateData
+): SampleDataFrameAdapterResult {
+  return {
+    data: toSampleRows(template),
+    columns: toSampleColumns(template),
+    rowKey: 'sampleId',
+  }
+}
+
+export function toSampleOptions(
+  template: SampleSheetTemplate | SampleSheetTemplateData
+): SampleOptionsAdapterResult {
+  const data = getTemplateData(template, 'sample-sheet')
+  validateSampleSheetData(data)
+  return data.samples.map((sample): SelectOption<string> => ({
+    value: sample.sampleId,
+    label: sample.name ?? sample.sampleId,
+    description: [sample.group, sample.batch].filter(Boolean).join(' / ') || undefined,
+  }))
+}
+
+function sampleColumnKey(columnId: string): string {
+  const aliases: Record<string, string> = {
+    sample_id: 'sampleId',
+    plate_id: 'plateId',
+    well_id: 'wellId',
+  }
+  return aliases[columnId] ?? columnId
+}

package/src/templates/sampleSheetBuilder.ts

@@ -0,0 +1,23 @@
+import { normalizeSampleRecord } from './sampleNormalizers'
+import { createTemplateEnvelope } from './templateEnvelopes'
+import { validateSampleSheetData } from './templateValidators'
+import type {
+  CreateSampleSheetTemplateOptions,
+  SampleSheetTemplate,
+  SampleSheetTemplateData,
+} from './types'
+
+export function createSampleSheetTemplate(
+  options: CreateSampleSheetTemplateOptions
+): SampleSheetTemplate {
+  const data: SampleSheetTemplateData = {
+    samples: options.samples.map(normalizeSampleRecord),
+    columns: options.columns ?? [
+      { id: 'sampleId', label: 'Sample ID', type: 'string', required: true, groupable: false },
+      { id: 'name', label: 'Name', type: 'string', required: false, groupable: false },
+    ],
+    groups: options.groups ?? [],
+  }
+  validateSampleSheetData(data)
+  return createTemplateEnvelope('sample-sheet', data, options.metadata ?? {})
+}

package/src/templates/targetedMetabolomicsCollectionBuilder.ts

@@ -0,0 +1,79 @@
+import { createAssayMatrixTemplate } from './assayMatrixBuilder'
+import { createCalibrationCurveTemplate } from './calibrationCurveBuilder'
+import { createInstrumentRunTemplate } from './instrumentRunBuilder'
+import { createReagentListTemplate } from './reagentListBuilder'
+import { createSamplePrepTemplate } from './samplePrepBuilder'
+import { createSampleSheetTemplate } from './sampleSheetBuilder'
+import { presetSampleRecords } from './sampleNormalizers'
+import {
+  firstFeatureName,
+  normalizeInternalStandardReagents,
+  normalizeMetaboliteFeatures,
+  targetedMetabolomicsRunItems,
+} from './targetedMetabolomicsHelpers'
+import { createTemplateCollection } from './templateEnvelopes'
+import type {
+  CreateTargetedMetabolomicsCollectionOptions,
+  TemplateCollectionEnvelope,
+} from './types'
+
+export function createTargetedMetabolomicsCollection(
+  options: CreateTargetedMetabolomicsCollectionOptions = {}
+): TemplateCollectionEnvelope {
+  const sampleRecords = presetSampleRecords(options.samples ?? ['S001', 'S002'])
+  const responseUnit = options.responseUnit ?? 'peak area ratio'
+  const concentrationUnit = options.concentrationUnit ?? 'uM'
+  const metaboliteFeatures = normalizeMetaboliteFeatures(
+    options.metabolites ?? ['Glucose', 'Lactate', 'Pyruvate'],
+    responseUnit,
+  )
+  const sampleSheet = createSampleSheetTemplate({ samples: sampleRecords })
+  const samplePrep = createSamplePrepTemplate({
+    samples: sampleRecords.map(sample => sample.sampleId),
+    prepType: options.prepType ?? 'extraction',
+    protocolName: 'Metabolomics sample preparation',
+    outputVolume: options.outputVolume ?? 50,
+    metadata: { assay: 'targeted-metabolomics' },
+  })
+  const reagents = createReagentListTemplate({
+    reagents: normalizeInternalStandardReagents(
+      options.internalStandards ?? ['Stable isotope internal standard mix'],
+    ),
+    metadata: { assay: 'targeted-metabolomics' },
+  })
+  const calibrationCurve = createCalibrationCurveTemplate({
+    concentrations: options.standardConcentrations ?? [0.1, 1, 10, 100],
+    analyte: options.calibrationAnalyte ?? firstFeatureName(metaboliteFeatures, 'Metabolite panel'),
+    unit: concentrationUnit,
+    responseUnit,
+    model: 'linear-weighted-1-x',
+    includeQc: options.includeQc,
+    metadata: { assay: 'targeted-metabolomics' },
+  })
+  const instrumentRun = createInstrumentRunTemplate({
+    items: targetedMetabolomicsRunItems(
+      sampleRecords,
+      calibrationCurve.data.points,
+      options.includeQc !== false,
+    ),
+    method: options.method ?? 'Targeted metabolomics',
+    instrument: options.instrument ?? 'LC-MS',
+    includeBlanks: false,
+    includeQc: false,
+    metadata: { assay: 'targeted-metabolomics' },
+  })
+  const assayMatrix = createAssayMatrixTemplate({
+    samples: sampleRecords.map(sample => ({
+      sampleId: sample.sampleId,
+      name: sample.name,
+      group: sample.group,
+      metadata: sample.metadata ?? {},
+    })),
+    features: metaboliteFeatures,
+    metadata: { assay: 'targeted-metabolomics', responseUnit },
+  })
+  return createTemplateCollection(
+    [sampleSheet, samplePrep, reagents, instrumentRun, calibrationCurve, assayMatrix],
+    { preset: 'targeted-metabolomics', ...(options.metadata ?? {}) }
+  )
+}