@molgenis/vip-report-template 5.5.3 → 5.5.5

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@molgenis/vip-report-template",
-  "version": "5.5.3",
+  "version": "5.5.5",
   "description": "Report Template for Variant Call Format (VCF) Report Generator",
   "scripts": {
     "build": "vite build",
@@ -15,33 +15,33 @@
   },
   "license": "LGPL-3.0",
   "devDependencies": {
-    "@molgenis/vite-plugin-inline": "^1.0.13",
-    "@typescript-eslint/eslint-plugin": "^5.61.0",
-    "@typescript-eslint/parser": "^5.61.0",
-    "@vitest/coverage-v8": "^0.32.4",
+    "@molgenis/vite-plugin-inline": "^1.0.14",
+    "@typescript-eslint/eslint-plugin": "^6.6.0",
+    "@typescript-eslint/parser": "^6.6.0",
+    "@vitest/coverage-v8": "^0.34.4",
     "bulma": "^0.9.4",
-    "eslint": "^8.44.0",
-    "eslint-config-prettier": "^8.8.0",
-    "eslint-plugin-prettier": "^4.2.1",
-    "eslint-plugin-solid": "^0.12.1",
+    "eslint": "^8.49.0",
+    "eslint-config-prettier": "^9.0.0",
+    "eslint-plugin-prettier": "^5.0.0",
+    "eslint-plugin-solid": "^0.13.0",
     "husky": "^8.0.3",
     "jsdom": "^22.1.0",
-    "prettier": "^2.8.8",
-    "sass": "^1.63.6",
-    "typescript": "^5.1.6",
-    "vite": "^4.4.0",
+    "prettier": "^3.0.3",
+    "sass": "^1.66.1",
+    "typescript": "^5.2.2",
+    "vite": "^4.4.9",
     "vite-plugin-solid": "^2.7.0",
-    "vitest": "^0.32.4"
+    "vitest": "^0.34.4"
   },
   "dependencies": {
-    "@fortawesome/fontawesome-svg-core": "^6.4.0",
-    "@fortawesome/free-solid-svg-icons": "^6.4.0",
-    "@molgenis/vip-report-api": "^4.4.2",
-    "@molgenis/vip-report-vcf": "^1.4.2",
-    "@solidjs/router": "^0.8.2",
+    "@fortawesome/fontawesome-svg-core": "^6.4.2",
+    "@fortawesome/free-solid-svg-icons": "^6.4.2",
+    "@molgenis/vip-report-api": "^4.4.4",
+    "@molgenis/vip-report-vcf": "^1.4.4",
+    "@solidjs/router": "^0.8.3",
     "base64-js": "^1.5.1",
-    "igv": "^2.15.8",
-    "solid-js": "^1.7.7"
+    "igv": "^2.15.10",
+    "solid-js": "^1.7.11"
   },
   "lint-staged": {
     "src/**/*.{tsx,ts}": [

package/src/__tests__/decisionTreeUtils.test.ts

@@ -38,7 +38,7 @@ test("Get DecisionTree Path", () => {
     },
   } as unknown as Item<Record>;
   expect(getDecisionTreePath({ info: { CSQ: fieldMetaCsq }, lines: [], format: {}, samples: [] }, variant, 0)).toBe(
-    "gnomad&mvl&clinvar&exit"
+    "gnomad&mvl&clinvar&exit",
   );
 });
 
@@ -70,6 +70,6 @@ test("Get DecisionTree Path - no VIPP", () => {
     },
   } as unknown as Item<Record>;
   expect(getDecisionTreePath({ info: { CSQ: fieldMetaCsq }, lines: [], format: {}, samples: [] }, variant, 0)).toBe(
-    undefined
+    undefined,
   );
 });

package/src/__tests__/query.test.ts

@@ -178,7 +178,7 @@ describe("query utilities", () => {
 
   test("sampleFieldKey", () => {
     expect(sampleFieldKey({ id: 1, data: { person: person, index: 0, proband: false } }, fieldMeta1)).toStrictEqual(
-      "s/0/CSQ/field1"
+      "s/0/CSQ/field1",
     );
   });
 

package/src/__tests__/sortUtils.test.ts

@@ -59,7 +59,7 @@ describe("sort utilities", () => {
       createRecordSort(metadata, {
         property: ["n", "n_string0"],
         compare: "asc",
-      })
+      }),
     ).toStrictEqual({ orders: [{ field: nString0Meta, direction: DIRECTION_ASCENDING }] });
   });
 
@@ -68,7 +68,7 @@ describe("sort utilities", () => {
       createRecordSort(metadata, {
         property: ["n", "n_object0", 1],
         compare: "asc",
-      })
+      }),
     ).toStrictEqual({ orders: [{ field: nString2Meta, direction: DIRECTION_ASCENDING }] });
   });
 
@@ -77,7 +77,7 @@ describe("sort utilities", () => {
       createRecordSort(metadata, {
         property: ["n", "n_unknown"],
         compare: "asc",
-      })
+      }),
     ).toThrowError();
   });
 });

package/src/__tests__/viewUtils.test.ts

@@ -33,13 +33,13 @@ test("Get specific consequence - out of bounds", () => {
 
 test("Get specific consequence - -1", () => {
   expect(() => getSpecificConsequence([valueArraya, valueArrayb], -1)).toThrowError(
-    "Consequences index must be 0 or higher."
+    "Consequences index must be 0 or higher.",
   );
 });
 
 test("Get Consequence Label", () => {
   expect(getConsequenceLabel([valueArraya, valueArrayb], 1, [fieldMeta1, fieldMetaCsq, fieldMeta2])).toBe(
-    "testValue2b"
+    "testValue2b",
   );
 });
 

package/src/components/GenomeBrowser.tsx

@@ -3,7 +3,7 @@ import igv, { Browser } from "igv";
 import api from "../Api";
 import { fromByteArray } from "base64-js";
 import { writeVcf } from "@molgenis/vip-report-vcf/src/VcfWriter";
-import { ComposedQuery, Cram, Sample } from "@molgenis/vip-report-api/src/Api";
+import { ComposedQuery, Sample } from "@molgenis/vip-report-api/src/Api";
 
 async function createVcf(contig: string, position: number, samples: Sample[]): Promise<Uint8Array> {
   const query: ComposedQuery = {
@@ -22,14 +22,14 @@ async function createVcf(contig: string, position: number, samples: Sample[]): P
   const data = await Promise.all([api.getRecordsMeta(), api.getRecords({ query, size: Number.MAX_SAFE_INTEGER })]);
   const vcf = writeVcf(
     { metadata: data[0], data: data[1].items.map((item) => item.data) },
-    { samples: samples.map((sample) => sample.person.individualId) }
+    { samples: samples.map((sample) => sample.person.individualId) },
   );
   return toBytes(vcf);
 }
 
 const toBytes = (str: string): Uint8Array => Uint8Array.from(str.split("").map((letter) => letter.charCodeAt(0)));
 
-const createBrowserConfig = async (contig: string, position: number, samples: Sample[]): Promise<unknown | null> => {
+const createBrowserConfig = async (contig: string, position: number, samples: Sample[]): Promise<unknown> => {
   const data = await Promise.all([
     api.getFastaGz(contig, position),
     createVcf(contig, position, samples),

package/src/components/InfoCollapsablePane.tsx

@@ -39,7 +39,7 @@ export const InfoCollapsablePane: Component<{
         });
       }
       throw new Error(`Nested field '${field.id}' needs to have a parent field.`);
-    })
+    }),
   );
   return (
     <>

package/src/components/SampleTable.tsx

@@ -99,7 +99,7 @@ export const SampleTable: Component<{
                     <Show when={getPhenotypes(sample.data.person.individualId).length > 0}>
                       <Anchor
                         href={`https://vibe.molgeniscloud.org/?phenotypes=${getPhenotypes(
-                          sample.data.person.individualId
+                          sample.data.person.individualId,
                         )
                           .map((feature) => feature.type.id)
                           .join(",")}`}

package/src/components/VariantInfoTable.tsx

@@ -16,7 +16,7 @@ export const VariantInfoTable: Component<{
           <tbody>
             <For
               each={Object.values(props.infoFields).filter(
-                (info) => !info.nested && props.record.data.n[info.id] !== undefined
+                (info) => !info.nested && props.record.data.n[info.id] !== undefined,
               )}
             >
               {(infoField) => (

package/src/components/VariantSampleTable.tsx

@@ -13,7 +13,7 @@ export const VariantSampleTable: Component<{
   record: Item<Record>;
 }> = (props) => {
   const sampleFields = createMemo((): FieldMetadata[] =>
-    Object.keys(props.sampleValues[0]).map((fieldId) => props.formatFields[fieldId])
+    Object.keys(props.sampleValues[0]).map((fieldId) => props.formatFields[fieldId]),
   );
   return (
     <div style={{ display: "grid" }}>

package/src/components/filter/Filter.tsx

@@ -1,10 +1,8 @@
 import { Component, Match, Switch } from "solid-js";
 import { FieldMetadata } from "@molgenis/vip-report-vcf/src/MetadataParser";
 import { FilterCategorical } from "./FilterCategorical";
-import { FilterIntegerVim } from "./FilterIntegerVim";
 import { FilterIntegerGq } from "./FilterIntegerGq";
 import { FilterIntegerDp } from "./FilterIntegerDp";
-import { FilterIntegerVid } from "./FilterIntegerVid";
 import { Item, Query, Sample } from "@molgenis/vip-report-api/src/Api";
 import { FilterClinVar } from "./FilterClinVar";
 import { isAnyCsqInfo } from "../../utils/csqUtils";
@@ -30,12 +28,6 @@ export const Filter: Component<FilterProps> = (props) => {
         <Match when={props.field.id === "DP"}>
           <FilterIntegerDp {...props} />
         </Match>
-        <Match when={props.field.id === "VID"}>
-          <FilterIntegerVid {...props} />
-        </Match>
-        <Match when={props.field.id === "VIM"}>
-          <FilterIntegerVim {...props} />
-        </Match>
         <Match when={props.field.id === "VIAB"}>
           <FilterAllelicBalance {...props} />
         </Match>

package/src/components/filter/FilterInheritance.tsx

@@ -0,0 +1,132 @@
+import { Component } from "solid-js";
+import { Checkbox, CheckboxEvent } from "../Checkbox";
+import { selector, selectorKey } from "../../utils/query";
+import { Item, Query, QueryClause, Sample, Selector } from "@molgenis/vip-report-api/src/Api";
+import { FieldMetadata } from "@molgenis/vip-report-vcf/src/MetadataParser";
+import { FilterChangeEvent, FilterClearEvent } from "./Filters";
+
+export type FilterInheritanceProps = {
+  vimField: FieldMetadata;
+  vidField: FieldMetadata;
+  query?: Query;
+  onChange: (event: FilterChangeEvent) => void;
+  onClear: (event: FilterClearEvent) => void;
+  sample: Item<Sample>;
+  key: string;
+};
+export const FilterInheritance: Component<FilterInheritanceProps> = (props) => {
+  const VIM_TRUE = "VIM_true";
+  const VIM_MISSING = "VIM_missing";
+  const VID = "VID";
+
+  let isVimMissingChecked = false;
+  let isVimTrueChecked = false;
+  let isVidChecked = false;
+
+  const vimFieldSelector: Selector = ["s", props.sample.data.index, ...selector(props.vimField)];
+  const vidFieldSelector: Selector = ["s", props.sample.data.index, ...selector(props.vidField)];
+
+  if (props.query !== undefined) {
+    (props.query?.args as QueryClause[]).forEach((query) => {
+      const selectorKeyValue = selectorKey(query.selector);
+      if (selectorKeyValue === selectorKey(vimFieldSelector) && query.args === 1) {
+        isVimTrueChecked = true;
+      } else if (
+        selectorKeyValue === selectorKey(vimFieldSelector) &&
+        (query.args === null || query.args === undefined)
+      ) {
+        isVimMissingChecked = true;
+      } else if (selectorKeyValue === selectorKey(vidFieldSelector) && query.args === 1) {
+        isVidChecked = true;
+      }
+    });
+  }
+  const onFilterChange = (event: CheckboxEvent) => {
+    const queries: QueryClause[] = [];
+    if ((event.value === VIM_TRUE && event.checked) || (isVimTrueChecked && event.value !== VIM_TRUE)) {
+      queries.push({
+        selector: vimFieldSelector,
+        operator: "==",
+        args: 1,
+      });
+      isVimTrueChecked = true;
+    } else if (isVimTrueChecked && event.value === VIM_TRUE && !event.checked) {
+      isVimTrueChecked = false;
+    }
+
+    if ((event.value === VIM_MISSING && event.checked) || (isVimMissingChecked && event.value !== VIM_MISSING)) {
+      queries.push(
+        {
+          selector: vimFieldSelector,
+          operator: "==",
+          args: null,
+        },
+        {
+          selector: vimFieldSelector,
+          operator: "==",
+          args: undefined,
+        },
+      );
+      isVimMissingChecked = true;
+    } else if (isVimMissingChecked && event.value === VIM_MISSING && !event.checked) {
+      isVimMissingChecked = false;
+    }
+    if ((event.value === VID && event.checked) || (isVidChecked && event.value !== VID)) {
+      queries.push({
+        selector: vidFieldSelector,
+        operator: "==",
+        args: 1,
+      });
+      isVidChecked = true;
+    } else if (isVidChecked && event.value === VID && !event.checked) {
+      isVidChecked = false;
+    }
+    if (queries.length > 0) {
+      props.onChange({
+        key: props.key,
+        query: {
+          operator: "or",
+          args: queries,
+        },
+      });
+    } else {
+      props.onClear({ key: props.key });
+    }
+  };
+
+  return (
+    <>
+      <div class="control">
+        <Checkbox
+          value={VIM_TRUE}
+          label="Match"
+          desc="Genotypes, affected statuses and known gene inheritance patterns match (can include de novo variants)."
+          checked={isVimTrueChecked}
+          onChange={onFilterChange}
+        />
+      </div>
+      <div class="control">
+        <Checkbox
+          value={VIM_MISSING}
+          label="Match: Possible"
+          desc="Genotypes, affected statuses match but gene inheritance pattern is unknown (can include de novo variants)."
+          checked={isVimMissingChecked}
+          onChange={onFilterChange}
+        />
+      </div>
+      <div class="control">
+        <Checkbox
+          value={VID}
+          label="De novo"
+          desc="On autosomes:
+- Available parents do not have the variant, or genotype is missing.
+On the X chromosome:
+- Female proband: same as autosomes.
+- Male proband: Mother does not have the variant, or mother genotype missing."
+          checked={isVidChecked}
+          onChange={onFilterChange}
+        />
+      </div>
+    </>
+  );
+};

package/src/components/filter/SampleFilters.tsx

@@ -1,10 +1,11 @@
-import { Component, For } from "solid-js";
+import { Component, For, Show } from "solid-js";
 import { FieldMetadata } from "@molgenis/vip-report-vcf/src/MetadataParser";
 import { Item, Sample } from "@molgenis/vip-report-api/src/Api";
 import { Filter } from "./Filter";
 import { FilterQueries } from "../../store";
-import { sampleFieldKey } from "../../utils/query";
+import { sampleCustomKey, sampleFieldKey } from "../../utils/query";
 import { FilterChangeEvent, FilterClearEvent } from "./Filters";
+import { FilterInheritance } from "./FilterInheritance";
 
 export const SampleFilters: Component<{
   sample: Item<Sample>;
@@ -17,11 +18,38 @@ export const SampleFilters: Component<{
     throw Error("Cannot create Sample filters without a sample.");
   }
 
+  const qualityFields = props.fields.filter((field) => field.id !== "VIM" && field.id !== "VID");
+  let vimField: FieldMetadata | undefined;
+  let vidField: FieldMetadata | undefined;
+  props.fields.forEach((field) => {
+    if (field.id === "VIM") {
+      vimField = field;
+    } else if (field.id === "VID") {
+      vidField = field;
+    }
+  });
+
+  const inheritanceFilterKey: string = sampleCustomKey(props.sample, "VIP_Inheritance");
   return (
     <>
-      <p class="has-text-weight-semibold">{props.sample.data.person.individualId}</p>
+      <Show when={vimField !== undefined && vidField !== undefined}>
+        <p class="has-text-weight-semibold">{props.sample.data.person.individualId}: Inheritance</p>
+        <div class="field">
+          {" "}
+          <FilterInheritance
+            vimField={vimField as FieldMetadata}
+            vidField={vidField as FieldMetadata}
+            query={props.queries ? props.queries[inheritanceFilterKey] : undefined}
+            onChange={props.onChange}
+            onClear={props.onClear}
+            sample={props.sample}
+            key={inheritanceFilterKey}
+          />
+        </div>
+      </Show>
+      <p class="has-text-weight-semibold">{props.sample.data.person.individualId}: Quality</p>
       <div class="field">
-        <For each={props.fields}>
+        <For each={qualityFields}>
           {(field) => (
             <>
               {" "}

package/src/components/record/info/ClinVar.tsx

@@ -32,14 +32,14 @@ export const ClinVar: Component<FieldProps> = (props) => {
   };
 
   const href = () => {
-    const clinVarIdsField = getCsqInfoIndex(props.infoMeta, "clinVar");
-    const clinVarIds = clinVarIdsField ? (getCsqInfo(props.info, clinVarIdsField) as number[]) : [];
+    const clinVarIdsField = getCsqInfoIndex(props.infoMeta, "clinVar_CLNID");
+    const clinVarIds = clinVarIdsField !== -1 ? (getCsqInfo(props.info, clinVarIdsField) as number[]) : [];
     return clinVarIds.length === 1 ? `https://www.ncbi.nlm.nih.gov/clinvar/variation/${clinVarIds[0]}/` : undefined;
   };
 
   const description = () => {
     const statusField = getCsqInfoIndex(props.infoMeta, "clinVar_CLNREVSTAT");
-    const status = statusField ? (getCsqInfo(props.info, statusField) as string[]) : [];
+    const status = statusField !== -1 ? (getCsqInfo(props.info, statusField) as string[]) : [];
     if (status.length === 0) return;
 
     let description;

package/src/index.tsx

@@ -29,7 +29,7 @@ library.add(
   faDownload,
   faExternalLink,
   faHome,
-  faSearch
+  faSearch,
 );
 
 function processIcons() {
@@ -49,5 +49,5 @@ render(
       <App />
     </Provider>
   ),
-  document.body
+  document.body,
 );

package/src/mocks/GRCh37/vcf/family.vcf.blob

@@ -95,7 +95,7 @@
 ##VIP_Version=5.6.0
 ##VIP_Command=nextflow -C /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/config/nxf_vcf.config,/groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/output/test_snv_proband_trio/custom.cfg -log /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/output/test_snv_proband_trio/.nxf.log run /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/vip_vcf.nf -offline -profile slurm -with-report /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/output/test_snv_proband_trio/nxf_report.html -with-timeline /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/output/test_snv_proband_trio/nxf_timeline.html --input /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/resources/snv_proband_trio.tsv --output /groups/umcg-gcc/tmp01/projects/vip/fastq/umcg-bcharbon/vip/test/output/test_snv_proband_trio -resume
 #CHROM	POS	ID	REF	ALT	QUAL	FILTER	INFO	FORMAT	Patient	Father	MotherHasQuiteALongName	Sister	Nephew	Unrelated
-1	1701	.	T	C	.	PASS	CSQ=C|intergenic_variant|MODIFIER||||||||||||||||1||||1||||||||||||||||||||||||||||||||||||||||||||||||||||||LQ|chrom&gene&exit_rm;DP=131;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:64802:0:OK:HR&GQ&DP&VIM&VID&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
+1	1701	.	T	C	.	PASS	CSQ=C|intergenic_variant|MODIFIER||||||||||||||||1||||1||||||||||||||||||||||||||||||||||||||||||||||||||||||LQ|chrom&gene&exit_rm;DP=131;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:64802:.:OK:HR&GQ&DP&VIM&VID&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 1	10042538	.	C	T	.	PASS	CSQ=T|missense_variant|MODERATE|NMNAT1|64802|Transcript|NM_001297778.1|protein_coding|5/5||NM_001297778.1:c.619C>T|NP_001284707.1:p.Arg207Trp|778/3796|619/840|207/279|R/W|Cgg/Tgg|rs142968179&CM127756|1||1||1|EntrezGene|||||0.04|0.08||pathogenic||1&1|26103963&22842229&22842230|||||||101|0|-36|-16|17|0.00|0.00|0.00|0.00|NMNAT1|VUS|0.13080463||||||||1.09||AR||LP||||3.917000|1:10042538-10042538|3.88948e-05|0|37133|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,T|downstream_gene_variant|MODIFIER|NMNAT1|64802|Transcript|NM_001297779.2|protein_coding||||||||||rs142968179&CM127756|1|714|1|||EntrezGene||||||||pathogenic||1&1|26103963&22842229&22842230||||||||0|-36|-16|17|0.00|0.00|0.00|0.00|NMNAT1|VUS|0.12802194||||||||1.09||AR||LP||||3.917000|1:10042538-10042538|3.88948e-05|0|37133|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,T|missense_variant|MODERATE|NMNAT1|64802|Transcript|NM_022787.4|protein_coding|5/5||NM_022787.4:c.619C>T|NP_073624.2:p.Arg207Trp|716/3734|619/840|207/279|R/W|Cgg/Tgg|rs142968179&CM127756|1||1|||EntrezGene|||||0.04|0.08||pathogenic||1&1|26103963&22842229&22842230|||||||101|0|-36|-16|17|0.00|0.00|0.00|0.00|NMNAT1|VUS|0.14871566||||||||1.09||AR||LP||||3.917000|1:10042538-10042538|3.88948e-05|0|37133|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp;VIPC_S=LQ	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:10:AR:1:64802:1:LQ,LQ,LQ:HR&GQ&exit_lq,HR&GQ&exit_lq,HR&GQ&exit_lq	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 1	16375583	.	GA	G	.	PASS	CSQ=-|intron_variant|MODIFIER|CLCNKB|1188|Transcript|NM_000085.5|protein_coding||7/19|NM_000085.5:c.656-31del|||||||rs751608665|1||1||1|EntrezGene||||||||uncertain_significance&pathogenic||1|||||||||20|45|-14|-45|0.05|0.00|0.00|0.00|CLCNKB|VUS|0.032756623||||||HP:0000951||1.439||AR||LP||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,-|frameshift_variant|HIGH|CLCNKB|1188|Transcript|NM_001165945.2|protein_coding|1/13||NM_001165945.2:c.118del|NP_001159417.2:p.Arg40GlyfsTer4|328/2174|118/1554|40/517|R/X|Agg/gg|rs751608665|1||1|||EntrezGene||||||||uncertain_significance&pathogenic||1|||||||||20|45|-14|-45|0.05|0.00|0.00|0.00|CLCNKB|VUS|0.9124473||||||HP:0000951||1.439||AR||LP||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,-|regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000001994|promoter||||||||||rs751608665|1|||||||||||||uncertain_significance&pathogenic||1|||||||||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm,-|regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000922299|CTCF_binding_site||||||||||rs751608665|1|||||||||||||uncertain_significance&pathogenic||1|||||||||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm,-|TF_binding_site_variant|MODIFIER|||MotifFeature|ENSM00533524886|||||||||||rs751608665|1||1|||||||||||uncertain_significance&pathogenic||1|||ENSPFM0617|1|N||ZBTB7B&ZBTB7A&ZBTB7C||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm,-|TF_binding_site_variant|MODIFIER|||MotifFeature|ENSM00529659450|||||||||||rs751608665|1||1|||||||||||uncertain_significance&pathogenic||1|||ENSPFM0566|3|N||TEAD4::MAX||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm,-|TF_binding_site_variant|MODIFIER|||MotifFeature|ENSM00529435523|||||||||||rs751608665|1||1|||||||||||uncertain_significance&pathogenic||1|||ENSPFM0544|3|N||TEAD4::FIGLA||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm,-|TF_binding_site_variant|MODIFIER|||MotifFeature|ENSM00910553844|||||||||||rs751608665|1||1|||||||||||uncertain_significance&pathogenic||1|||ENSPFM0383|17|N||MGA::EVX1||||||||||||||||||||||||||||-0.860000|1:16375584-16375585|0.000548455|0|638508|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm;VIPC_S=OK	GT:AD:DP:GQ:VI:VIC:VID:VIG:VIM:VIPC_S:VIPP_S:VIS	1|0:25,25:50:50:AR:1_16376412_G_A,1_16376412_G_N:0:1188:1:OK,OK,OK,OK,OK,OK,OK,OK:HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok:AR_C	1|0:25,25:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.
 1	16376412	n_alt	G	N	.	PASS	CSQ=N|splice_donor_variant|HIGH|CLCNKB|1188|Transcript|NM_000085.5|protein_coding||10/19||||||||CS1211892&CS971662|1||1||1|EntrezGene||||||||||1&1||||||||||||||||||VUS|0.9316635||||||HP:0000951||1.439||AR||||||4.909000||||||||LP|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&spliceAI&utr5&capice&exit_lp,N|splice_donor_variant|HIGH|CLCNKB|1188|Transcript|NM_001165945.2|protein_coding||3/12||||||||CS1211892&CS971662|1||1|||EntrezGene||||||||||1&1||||||||||||||||||VUS|0.9316635||||||HP:0000951||1.439||AR||||||4.909000||||||||LP|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&spliceAI&utr5&capice&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VIC:VID:VIG:VIM:VIPC_S:VIPP_S:VIS	1|0:5,45:50:.:AR,AD:1_16376412_G_A,1_16375583_GA_G:1:1188:1:OK,OK:HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok:AR_C	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.:.:.
@@ -103,9 +103,9 @@
 1	17349219	g_ref	G	A	.	PASS	CSQ=A|missense_variant|MODERATE|SDHB|6390|Transcript|NM_003000.3|protein_coding|7/8||NM_003000.3:c.649C>T|NP_002991.2:p.Arg217Cys|662/1015|649/843|217/280|R/C|Cgc/Tgc|rs200245469&CM094752&CM1210440&COSV64965760|1||-1||1|EntrezGene|||||0|1||likely_pathogenic|0&0&0&1|1&1&1&1||||||||180|28|6|6|5|0.00|0.00|0.00|0.00|SDHB|VUS|0.9769107||||||HP:0000951||2.452||AD&AR||LP||||9.093000||||183735|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:6390:1:OK:HR&GQ&DP&VIM&exit_ok	1|0:45,5:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	1|0:25,25:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 1	17355094	.	C	T	.	PASS	CSQ=T|splice_donor_variant|HIGH|SDHB|6390|Transcript|NM_003000.3|protein_coding||4/7|NM_003000.3:c.423+1G>A|||||||rs398122805&CS056774&CS062098&COSV64965540|1||-1||1|EntrezGene||||||||pathogenic|0&0&0&1|1&1&1&1|21348866&17667967&17804857&16405730&21565294&15383933||||||||-49|12|26|1|0.00|0.00|0.14|0.97|SDHB|VUS|0.991252||||||HP:0000951||2.452||AD&AR||LP||||7.131000|1:17355094-17355094|1.19344e-05|0|29896|Pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|0:5,45:50:50:AD:1:6390:1:OK:HR&GQ&DP&VIM&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 1	152520788	symbolic1	A	<DEL>	.	PASS	CSQ=deletion|transcript_ablation|HIGH|LCE3D|84648|Transcript|NM_032563.2|protein_coding|||||||||||1||-1||1|EntrezGene|||||||||||||||||||||||||||||||||||||||||||||||||||||VUS|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&annotSV&spliceAI&utr5&capice&exit_vus,deletion|upstream_gene_variant|MODIFIER|LCE3C|353144|Transcript|NM_178434.3|protein_coding|||||||||||1|2608|1|||EntrezGene|||||||||||||||||||||||||||||||||||||||||||||||||||||VUS|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&annotSV&spliceAI&utr5&capice&exit_vus,deletion|transcript_ablation|HIGH|LCE3E|353145|Transcript|NM_178435.4|protein_coding|||||||||||1||-1|||EntrezGene|||||||||||||||||||||||||||||||||||||||||||||||||||||VUS|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&annotSV&spliceAI&utr5&capice&exit_vus,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000946440||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001787329||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000013752||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000946442||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00000946443||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001505919||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001787330||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001787331||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001787332||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00701519957||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00905971885||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00522719201||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm;SVLEN=-49314;SVTYPE=DEL;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:0:OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK:HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok	0|0:50,0:50:50:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.	1|0:25,25:50:50:.:.:.:.:.
-2	321682	.	T	<DEL>	.	PASS	CSQ=deletion|non_coding_transcript_exon_variant&intron_variant&feature_truncation|MODIFIER|LINC01865|105373350|Transcript|NR_146953.1|lncRNA|3/4|3/3|||685-?/2100||||||1||1||1|EntrezGene||||||||||||||||||||||||||||||||||||||||||3|1A_(cf_Gene_count%2C_RE_gene%2C_+0.00)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(1_gene%2C_+0.00)%3B5F_(+0.00)|0.0|||||||||VUS|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&annotSV&exit_vus;END=321887;SVLEN=-205;SVTYPE=DEL;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:64802:0:OK:HR&GQ&DP&VIM&VID&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
+2	321682	.	T	<DEL>	.	PASS	CSQ=deletion|non_coding_transcript_exon_variant&intron_variant&feature_truncation|MODIFIER|LINC01865|105373350|Transcript|NR_146953.1|lncRNA|3/4|3/3|||685-?/2100||||||1||1||1|EntrezGene||||||||||||||||||||||||||||||||||||||||||3|1A_(cf_Gene_count%2C_RE_gene%2C_+0.00)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(1_gene%2C_+0.00)%3B5F_(+0.00)|0.0|||||||||VUS|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&annotSV&exit_vus;END=321887;SVLEN=-205;SVTYPE=DEL;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:0:64802:.:OK:HR&GQ&DP&VIM&VID&exit_ok	1|0:50,0:50:50:.:.:.:.:.:.	1|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 2	6693415	.	T	<DEL>	.	PASS	CSQ=deletion|regulatory_region_ablation&regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001914803||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524064657||||||||||||1||||1|||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524052275||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524121752||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524688093||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00525576244||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524108762||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524259723||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524175972||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524198224||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524134566||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00769910345||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524344258||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524278495||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524312437||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524083163||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524770333||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00829572188||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524396085||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00909212078||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524214908||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524150456||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524239498||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00524095954||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|TFBS_ablation&TF_binding_site_variant|MODERATE|||MotifFeature|ENSM00530094654||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm,deletion|intergenic_variant|MODIFIER||||||||||||||||1|||||||||||||||||||||||||||||||||||||||||||||||3|1B_(cf_Gene_count%2C_RE_gene%2C_-0.60)%3B2B_(cf_po_P_loss_source%2C_HI_and_OMIM_morbid%2C_+0.00)%3B3A_(0_gene%2C_+0.00)%3B5F_(+0.00)|-0.6|||||||||LQ|chrom&gene&exit_rm;END=6707844;SVLEN=-14429;SVTYPE=DEL;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:64802:0:OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK,OK:HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok,HR&GQ&DP&VIM&VID&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
-4	106320294	.	G	A	.	PASS	CSQ=A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_006903.4|protein_coding|7/11||NM_006903.4:c.596C>T|NP_008834.3:p.Pro199Leu|616/1586|596/918|199/305|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.985||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.7474259||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176866.2|protein_coding|4/8||NM_176866.2:c.377C>T|NP_789842.2:p.Pro126Leu|397/1367|377/699|126/232|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.992||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.75460654||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176867.3|protein_coding|2/6||NM_176867.3:c.185C>T|NP_789843.2:p.Pro62Leu|205/1175|185/507|62/168|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.995||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.89774835||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176869.3|protein_coding|8/12||NM_176869.3:c.683C>T|NP_789845.1:p.Pro228Leu|695/1665|683/1005|228/334|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1||1|EntrezGene|||||0|0.993||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.77676606||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001994744|promoter_flanking_region||||||||||rs138215926&CM1610192&COSV58994362|1|||||||||||||pathogenic|0&0&1|1&1&1|27523597||||||||||||||||||||||||||||||||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,50:50:50:AR:1:27068:1:OK,OK,OK,OK,OK:HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok	1|0:25,25:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	1|1:0,50:50:50:.:.:.:.:.:.
+4	106320294	.	G	A	.	PASS	CSQ=A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_006903.4|protein_coding|7/11||NM_006903.4:c.596C>T|NP_008834.3:p.Pro199Leu|616/1586|596/918|199/305|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.985||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.7474259||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176866.2|protein_coding|4/8||NM_176866.2:c.377C>T|NP_789842.2:p.Pro126Leu|397/1367|377/699|126/232|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.992||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.75460654||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176867.3|protein_coding|2/6||NM_176867.3:c.185C>T|NP_789843.2:p.Pro62Leu|205/1175|185/507|62/168|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1|||EntrezGene|||||0|0.995||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.89774835||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|missense_variant|MODERATE|PPA2|27068|Transcript|NM_176869.3|protein_coding|8/12||NM_176869.3:c.683C>T|NP_789845.1:p.Pro228Leu|695/1665|683/1005|228/334|P/L|cCg/cTg|rs138215926&CM1610192&COSV58994362|1||-1||1|EntrezGene|||||0|0.993||pathogenic|0&0&1|1&1&1|27523597|||||||98|-34|27|-2|-43|0.00|0.00|0.00|0.00|PPA2|VUS|0.77676606||||||||-1.922||AR||LP||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LP|chrom&gene&filter&vkgl&exit_lp,A|regulatory_region_variant|MODIFIER|||RegulatoryFeature|ENSR00001994744|promoter_flanking_region||||||||||rs138215926&CM1610192&COSV58994362|1|||||||||||||pathogenic|0&0&1|1&1&1|27523597||||||||||||||||||||||||||||||||||9.359000|4:106320294-106320294|0.000211803|0|372226|Pathogenic/Likely_pathogenic||criteria_provided&_multiple_submitters&_no_conflicts|LQ|chrom&gene&exit_rm;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|0:0,50:50:50:AD:1:27068:0:.:HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok,HR&GQ&DP&VIM&exit_ok	0|0:25,25:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	1|1:0,50:50:50:.:.:.:.:.:.
 9	107546633	.	AAAGAT	A	.	PASS	CSQ=-|frameshift_variant|HIGH|ABCA1|19|Transcript|NM_005502.4|protein_coding|50/50||NM_005502.4:c.6744_6748del|NP_005493.2:p.Phe2250ThrfsTer3|7057-7061/10408|6744-6748/6786|2248-2250/2261|TSF/TX|acATCTTtt/actt||1||-1||1|EntrezGene||||||||||||||||||||||||||||VUS|0.97944254|||||||LC|4.243||AD&AR||||||||||||||LP|chrom&gene&filter&vkgl&clinVar&gnomAD&sv&spliceAI&utr5&capice&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|1:0,10:10:.:AR:0:19:1:OK:HR&GQ&DP&VIM&exit_ok	0|1:1,49:50:50:.:.:.:.:.:.	1|0:0,50:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 9	107584864	.	AC	A	.	PASS	CSQ=-|frameshift_variant|HIGH|ABCA1|19|Transcript|NM_005502.4|protein_coding|19/50||NM_005502.4:c.2740del|NP_005493.2:p.Val914TrpfsTer8|3053/10408|2740/6786|914/2261|V/X|Gtg/tg||1||-1||1|EntrezGene|||||||||||||||||||33|-42|28|1|0.00|0.00|0.10|0.00|ABCA1|VUS|0.998016||||||HP:0000951|LC|4.243||AD&AR||LP||||4.010000||||||||LP|chrom&gene&filter&vkgl&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|0:10,90:50:50:AD:1:19:1:OK:HR&GQ&DP&VIM&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.
 9	107584865	.	C	G	.	PASS	CSQ=-|frameshift_variant|HIGH|ABCA1|19|Transcript|NM_005502.4|protein_coding|19/50||NM_005502.4:c.2740del|NP_005493.2:p.Val914TrpfsTer8|3053/10408|2740/6786|914/2261|V/X|Gtg/tg||1||-1||1|EntrezGene|||||||||||||||||||33|-42|28|1|0.00|0.00|0.10|0.00|ABCA1|VUS|0.998016||||||HP:0003124|HC|4.243||AD&AR||LP||||4.010000||||||||LP|chrom&gene&filter&vkgl&exit_lp;VIPC_S=OK	GT:AD:DP:GQ:VI:VID:VIG:VIM:VIPC_S:VIPP_S	1|0:10,90:50:50:AD:1:19:1:OK:HR&GQ&DP&VIM&exit_ok	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.	0|0:50,0:50:50:.:.:.:.:.:.

package/src/utils/ApiUtils.ts

@@ -124,7 +124,7 @@ export async function fetchRecords(params: Params) {
       order.field.parent?.id === "CSQ" &&
       isNumerical(order.field) &&
       order.field.number.type === "NUMBER" &&
-      order.field.number.count === 1
+      order.field.number.count === 1,
   );
 
   const fieldMetas = (recordsMeta.info.CSQ.nested as NestedFieldMetadata).items;

package/src/utils/query.ts

@@ -16,7 +16,7 @@ export function createSampleQuery(
   sample: Item<Sample>,
   search: string | undefined,
   filters: FilterQueries | undefined,
-  metadata: Metadata
+  metadata: Metadata,
 ): Query | null {
   const genotypeSelector: Selector = ["s", sample.data.index, "GT", "t"];
   const sampleQuery: Query = {
@@ -35,7 +35,7 @@ export function createSampleQuery(
 export function createQuery(
   search: string | undefined,
   filters: FilterQueries | undefined,
-  metadata: Metadata
+  metadata: Metadata,
 ): Query | null {
   let query: Query | null;
 
@@ -63,7 +63,7 @@ function createSearchQueryClausesInfo(search: string, infoMetadata: InfoMetadata
   if (infoMetadata.nested) {
     for (let i = 0; i < infoMetadata.nested.items.length; ++i) {
       clauses.push(
-        ...createSearchQueryClausesInfo(search, infoMetadata.nested.items[i], [...selector, "*", i.toString()])
+        ...createSearchQueryClausesInfo(search, infoMetadata.nested.items[i], [...selector, "*", i.toString()]),
       );
     }
   } else {
@@ -141,6 +141,10 @@ export function sampleFieldKey(sample: Item<Sample>, field: FieldMetadata): stri
   return selectorKey(sampleSelector(sample, field));
 }
 
+export function sampleCustomKey(sample: Item<Sample>, key: string): string {
+  return selectorKey(["s", sample.data.index, key]);
+}
+
 function sortPath(field: FieldMetadata): SortPath {
   return selector(field).filter((part) => part !== "*");
 }

package/src/views/SampleVariant.tsx

@@ -70,7 +70,7 @@ export const SampleVariant: Component<{
         <Show
           when={
             Object.values(props.recordsMeta.info).filter(
-              (info) => !info.nested && props.record.data.n[info.id] !== undefined
+              (info) => !info.nested && props.record.data.n[info.id] !== undefined,
             ).length > 0
           }
         >
@@ -87,7 +87,7 @@ export const SampleVariant: Component<{
             sampleValues={getRecordSamples(
               props.record.data,
               props.sample.data,
-              props.pedigreeSamples.map((item) => item.data)
+              props.pedigreeSamples.map((item) => item.data),
             )}
             record={props.record}
           />

package/src/views/SampleVariantConsequence.tsx

@@ -104,7 +104,7 @@ export const SampleVariantConsequence: Component<{
             sampleValues={getRecordSamples(
               props.variant.data,
               props.sample.data,
-              props.pedigreeSamples.map((item) => item.data)
+              props.pedigreeSamples.map((item) => item.data),
             )}
             record={props.variant}
           />

package/src/views/SampleVariants.tsx

@@ -14,7 +14,15 @@ import { SearchBox } from "../components/SearchBox";
 import { Sort, SortEvent } from "../components/Sort";
 import { Pager } from "../components/record/Pager";
 import { RecordDownload } from "../components/record/RecordDownload";
-import { createSampleQuery, infoSelector, infoSortPath, sampleSelector, selector, selectorKey } from "../utils/query";
+import {
+  createSampleQuery,
+  infoSelector,
+  infoSortPath,
+  sampleCustomKey,
+  sampleSelector,
+  selector,
+  selectorKey,
+} from "../utils/query";
 import { VariantsSampleTable } from "../components/VariantsSampleTable";
 import {
   fetchHtsFileMetadata,
@@ -112,7 +120,7 @@ export const SampleVariants: Component<{
           operator: "or",
           args: queries,
         },
-        selectorKey(selectorHpo)
+        selectorKey(selectorHpo),
       );
     }
 
@@ -141,7 +149,7 @@ export const SampleVariants: Component<{
             },
           ],
         },
-        selectorKey(selectorVim)
+        sampleCustomKey(props.sample, "VIP_Inheritance"),
       );
     }
     const gqField = props.recordsMeta.format?.GQ;
@@ -154,7 +162,7 @@ export const SampleVariants: Component<{
           operator: ">=",
           args: 20,
         },
-        selectorKey(selectorGq)
+        selectorKey(selectorGq),
       );
     }
     const viabField = props.recordsMeta.format?.VIAB;
@@ -162,7 +170,7 @@ export const SampleVariants: Component<{
       actions.setSampleVariantsFilterQuery(
         props.sample,
         getAllelicBalanceQuery(props.sample.data.index),
-        selectorKey(["s", props.sample.data.index, ...selector(viabField)])
+        selectorKey(["s", props.sample.data.index, ...selector(viabField)]),
       );
     }
   }

package/src/views/Variant.tsx

@@ -29,7 +29,7 @@ export const Variant: Component = () => {
           <Show
             when={
               Object.values(recordsMetadata().info).filter(
-                (info) => !info.nested && variant().data.n[info.id] !== undefined
+                (info) => !info.nested && variant().data.n[info.id] !== undefined,
               ).length > 0
             }
           >

package/src/components/filter/FilterIntegerVid.tsx

@@ -1,37 +0,0 @@
-import { Component } from "solid-js";
-import { FilterProps } from "./Filter";
-import { Checkbox, CheckboxEvent } from "../Checkbox";
-import { selector, selectorKey } from "../../utils/query";
-import { Item, Sample, Selector } from "@molgenis/vip-report-api/src/Api";
-
-export const FilterIntegerVid: Component<FilterProps> = (props) => {
-  const onFilterChange = (event: CheckboxEvent) => {
-    const fieldSelector: Selector = ["s", (props.sample as Item<Sample>).data.index, ...selector(props.field)];
-    if (event.checked)
-      props.onChange({
-        key: selectorKey(fieldSelector),
-        query: {
-          selector: fieldSelector,
-          operator: "==",
-          args: 1,
-        },
-      });
-    else props.onClear({ key: selectorKey(fieldSelector) });
-  };
-
-  return (
-    <div class="control">
-      <Checkbox
-        label="Inheritance: de novo"
-        desc="Inheritance De Novo:
-        On autosomes:
-        - available parents do not have the variant, or genotype is missing.
-        On the X chromosome:
-        - Female proband: same as autosomes.
-        - Male proband: Mother does not have the variant, or mother genotype missing."
-        checked={props.query && props.query.args === 1}
-        onChange={onFilterChange}
-      />
-    </div>
-  );
-};

package/src/components/filter/FilterIntegerVim.tsx

@@ -1,46 +0,0 @@
-import { Component } from "solid-js";
-import { FilterProps } from "./Filter";
-import { Checkbox, CheckboxEvent } from "../Checkbox";
-import { selector, selectorKey } from "../../utils/query";
-import { Item, Sample, Selector } from "@molgenis/vip-report-api/src/Api";
-
-export const FilterIntegerVim: Component<FilterProps> = (props) => {
-  const onFilterChange = (event: CheckboxEvent) => {
-    const fieldSelector: Selector = ["s", (props.sample as Item<Sample>).data.index, ...selector(props.field)];
-    if (event.checked)
-      props.onChange({
-        key: selectorKey(fieldSelector),
-        query: {
-          operator: "or",
-          args: [
-            {
-              selector: fieldSelector,
-              operator: "==",
-              args: 1,
-            },
-            {
-              selector: fieldSelector,
-              operator: "==",
-              args: null,
-            },
-            {
-              selector: fieldSelector,
-              operator: "==",
-              args: undefined,
-            },
-          ],
-        },
-      });
-    else props.onClear({ key: selectorKey(fieldSelector) });
-  };
-
-  return (
-    <div class="control">
-      <Checkbox
-        label="Inheritance: match"
-        checked={props.query && props.query.args !== undefined}
-        onChange={onFilterChange}
-      />
-    </div>
-  );
-};