@medplum/core 0.2.2 → 0.3.0

package/dist/fhir/MedicationKnowledge.d.ts

@@ -1,992 +0,0 @@
-import { CodeableConcept } from './CodeableConcept';
-import { DetectedIssue } from './DetectedIssue';
-import { DocumentReference } from './DocumentReference';
-import { Dosage } from './Dosage';
-import { Duration } from './Duration';
-import { Extension } from './Extension';
-import { Media } from './Media';
-import { Medication } from './Medication';
-import { Meta } from './Meta';
-import { Money } from './Money';
-import { Narrative } from './Narrative';
-import { ObservationDefinition } from './ObservationDefinition';
-import { Organization } from './Organization';
-import { Quantity } from './Quantity';
-import { Ratio } from './Ratio';
-import { Reference } from './Reference';
-import { Resource } from './Resource';
-import { Substance } from './Substance';
-/**
- * Information about a medication that is used to support knowledge.
- */
-export interface MedicationKnowledge {
-    /**
-     * This is a MedicationKnowledge resource
-     */
-    readonly resourceType: 'MedicationKnowledge';
-    /**
-     * The logical id of the resource, as used in the URL for the resource.
-     * Once assigned, this value never changes.
-     */
-    readonly id?: string;
-    /**
-     * The metadata about the resource. This is content that is maintained by
-     * the infrastructure. Changes to the content might not always be
-     * associated with version changes to the resource.
-     */
-    readonly meta?: Meta;
-    /**
-     * A reference to a set of rules that were followed when the resource was
-     * constructed, and which must be understood when processing the content.
-     * Often, this is a reference to an implementation guide that defines the
-     * special rules along with other profiles etc.
-     */
-    readonly implicitRules?: string;
-    /**
-     * The base language in which the resource is written.
-     */
-    readonly language?: string;
-    /**
-     * A human-readable narrative that contains a summary of the resource and
-     * can be used to represent the content of the resource to a human. The
-     * narrative need not encode all the structured data, but is required to
-     * contain sufficient detail to make it "clinically safe" for a human to
-     * just read the narrative. Resource definitions may define what content
-     * should be represented in the narrative to ensure clinical safety.
-     */
-    readonly text?: Narrative;
-    /**
-     * These resources do not have an independent existence apart from the
-     * resource that contains them - they cannot be identified independently,
-     * and nor can they have their own independent transaction scope.
-     */
-    readonly contained?: Resource[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the resource. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the resource and that modifies the
-     * understanding of the element that contains it and/or the understanding
-     * of the containing element's descendants. Usually modifier elements
-     * provide negation or qualification. To make the use of extensions safe
-     * and manageable, there is a strict set of governance applied to the
-     * definition and use of extensions. Though any implementer is allowed to
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension. Applications processing a
-     * resource are required to check for modifier extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * A code that specifies this medication, or a textual description if no
-     * code is available. Usage note: This could be a standard medication
-     * code such as a code from RxNorm, SNOMED CT, IDMP etc. It could also be
-     * a national or local formulary code, optionally with translations to
-     * other code systems.
-     */
-    readonly code?: CodeableConcept;
-    /**
-     * A code to indicate if the medication is in active use.  The status
-     * refers to the validity about the information of the medication and not
-     * to its medicinal properties.
-     */
-    readonly status?: string;
-    /**
-     * Describes the details of the manufacturer of the medication product.
-     * This is not intended to represent the distributor of a medication
-     * product.
-     */
-    readonly manufacturer?: Reference<Organization>;
-    /**
-     * Describes the form of the item.  Powder; tablets; capsule.
-     */
-    readonly doseForm?: CodeableConcept;
-    /**
-     * Specific amount of the drug in the packaged product.  For example,
-     * when specifying a product that has the same strength (For example,
-     * Insulin glargine 100 unit per mL solution for injection), this
-     * attribute provides additional clarification of the package amount (For
-     * example, 3 mL, 10mL, etc.).
-     */
-    readonly amount?: Quantity;
-    /**
-     * Additional names for a medication, for example, the name(s) given to a
-     * medication in different countries.  For example, acetaminophen and
-     * paracetamol or salbutamol and albuterol.
-     */
-    readonly synonym?: string[];
-    /**
-     * Associated or related knowledge about a medication.
-     */
-    readonly relatedMedicationKnowledge?: MedicationKnowledgeRelatedMedicationKnowledge[];
-    /**
-     * Associated or related medications.  For example, if the medication is
-     * a branded product (e.g. Crestor), this is the Therapeutic Moeity (e.g.
-     * Rosuvastatin) or if this is a generic medication (e.g. Rosuvastatin),
-     * this would link to a branded product (e.g. Crestor).
-     */
-    readonly associatedMedication?: Reference<Medication>[];
-    /**
-     * Category of the medication or product (e.g. branded product,
-     * therapeutic moeity, generic product, innovator product, etc.).
-     */
-    readonly productType?: CodeableConcept[];
-    /**
-     * Associated documentation about the medication.
-     */
-    readonly monograph?: MedicationKnowledgeMonograph[];
-    /**
-     * Identifies a particular constituent of interest in the product.
-     */
-    readonly ingredient?: MedicationKnowledgeIngredient[];
-    /**
-     * The instructions for preparing the medication.
-     */
-    readonly preparationInstruction?: string;
-    /**
-     * The intended or approved route of administration.
-     */
-    readonly intendedRoute?: CodeableConcept[];
-    /**
-     * The price of the medication.
-     */
-    readonly cost?: MedicationKnowledgeCost[];
-    /**
-     * The program under which the medication is reviewed.
-     */
-    readonly monitoringProgram?: MedicationKnowledgeMonitoringProgram[];
-    /**
-     * Guidelines for the administration of the medication.
-     */
-    readonly administrationGuidelines?: MedicationKnowledgeAdministrationGuidelines[];
-    /**
-     * Categorization of the medication within a formulary or classification
-     * system.
-     */
-    readonly medicineClassification?: MedicationKnowledgeMedicineClassification[];
-    /**
-     * Information that only applies to packages (not products).
-     */
-    readonly packaging?: MedicationKnowledgePackaging;
-    /**
-     * Specifies descriptive properties of the medicine, such as color,
-     * shape, imprints, etc.
-     */
-    readonly drugCharacteristic?: MedicationKnowledgeDrugCharacteristic[];
-    /**
-     * Potential clinical issue with or between medication(s) (for example,
-     * drug-drug interaction, drug-disease contraindication, drug-allergy
-     * interaction, etc.).
-     */
-    readonly contraindication?: Reference<DetectedIssue>[];
-    /**
-     * Regulatory information about a medication.
-     */
-    readonly regulatory?: MedicationKnowledgeRegulatory[];
-    /**
-     * The time course of drug absorption, distribution, metabolism and
-     * excretion of a medication from the body.
-     */
-    readonly kinetics?: MedicationKnowledgeKinetics[];
-}
-/**
- * Guidelines for the administration of the medication.
- */
-export interface MedicationKnowledgeAdministrationGuidelines {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * Dosage for the medication for the specific guidelines.
-     */
-    readonly dosage?: MedicationKnowledgeAdministrationGuidelinesDosage[];
-    /**
-     * Indication for use that apply to the specific administration
-     * guidelines.
-     */
-    readonly indicationCodeableConcept?: CodeableConcept;
-    /**
-     * Indication for use that apply to the specific administration
-     * guidelines.
-     */
-    readonly indicationReference?: Reference<ObservationDefinition>;
-    /**
-     * Characteristics of the patient that are relevant to the administration
-     * guidelines (for example, height, weight, gender, etc.).
-     */
-    readonly patientCharacteristics?: MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics[];
-}
-/**
- * Dosage for the medication for the specific guidelines.
- */
-export interface MedicationKnowledgeAdministrationGuidelinesDosage {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The type of dosage (for example, prophylaxis, maintenance,
-     * therapeutic, etc.).
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Dosage for the medication for the specific guidelines.
-     */
-    readonly dosage?: Dosage[];
-}
-/**
- * Characteristics of the patient that are relevant to the administration
- * guidelines (for example, height, weight, gender, etc.).
- */
-export interface MedicationKnowledgeAdministrationGuidelinesPatientCharacteristics {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * Specific characteristic that is relevant to the administration
-     * guideline (e.g. height, weight, gender).
-     */
-    readonly characteristicCodeableConcept?: CodeableConcept;
-    /**
-     * Specific characteristic that is relevant to the administration
-     * guideline (e.g. height, weight, gender).
-     */
-    readonly characteristicQuantity?: Quantity;
-    /**
-     * The specific characteristic (e.g. height, weight, gender, etc.).
-     */
-    readonly value?: string[];
-}
-/**
- * The price of the medication.
- */
-export interface MedicationKnowledgeCost {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The category of the cost information.  For example, manufacturers'
-     * cost, patient cost, claim reimbursement cost, actual acquisition cost.
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * The source or owner that assigns the price to the medication.
-     */
-    readonly source?: string;
-    /**
-     * The price of the medication.
-     */
-    readonly cost?: Money;
-}
-/**
- * Specifies descriptive properties of the medicine, such as color,
- * shape, imprints, etc.
- */
-export interface MedicationKnowledgeDrugCharacteristic {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * A code specifying which characteristic of the medicine is being
-     * described (for example, colour, shape, imprint).
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Description of the characteristic.
-     */
-    readonly valueCodeableConcept?: CodeableConcept;
-    /**
-     * Description of the characteristic.
-     */
-    readonly valueString?: string;
-    /**
-     * Description of the characteristic.
-     */
-    readonly valueQuantity?: Quantity;
-    /**
-     * Description of the characteristic.
-     */
-    readonly valueBase64Binary?: string;
-}
-/**
- * Identifies a particular constituent of interest in the product.
- */
-export interface MedicationKnowledgeIngredient {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The actual ingredient - either a substance (simple ingredient) or
-     * another medication.
-     */
-    readonly itemCodeableConcept?: CodeableConcept;
-    /**
-     * The actual ingredient - either a substance (simple ingredient) or
-     * another medication.
-     */
-    readonly itemReference?: Reference<Substance>;
-    /**
-     * Indication of whether this ingredient affects the therapeutic action
-     * of the drug.
-     */
-    readonly isActive?: boolean;
-    /**
-     * Specifies how many (or how much) of the items there are in this
-     * Medication.  For example, 250 mg per tablet.  This is expressed as a
-     * ratio where the numerator is 250mg and the denominator is 1 tablet.
-     */
-    readonly strength?: Ratio;
-}
-/**
- * The time course of drug absorption, distribution, metabolism and
- * excretion of a medication from the body.
- */
-export interface MedicationKnowledgeKinetics {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The drug concentration measured at certain discrete points in time.
-     */
-    readonly areaUnderCurve?: Quantity[];
-    /**
-     * The median lethal dose of a drug.
-     */
-    readonly lethalDose50?: Quantity[];
-    /**
-     * The time required for any specified property (e.g., the concentration
-     * of a substance in the body) to decrease by half.
-     */
-    readonly halfLifePeriod?: Duration;
-}
-/**
- * Categorization of the medication within a formulary or classification
- * system.
- */
-export interface MedicationKnowledgeMedicineClassification {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The type of category for the medication (for example, therapeutic
-     * classification, therapeutic sub-classification).
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Specific category assigned to the medication (e.g. anti-infective,
-     * anti-hypertensive, antibiotic, etc.).
-     */
-    readonly classification?: CodeableConcept[];
-}
-/**
- * The program under which the medication is reviewed.
- */
-export interface MedicationKnowledgeMonitoringProgram {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * Type of program under which the medication is monitored.
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Name of the reviewing program.
-     */
-    readonly name?: string;
-}
-/**
- * Associated documentation about the medication.
- */
-export interface MedicationKnowledgeMonograph {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The category of documentation about the medication. (e.g. professional
-     * monograph, patient education monograph).
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Associated documentation about the medication.
-     */
-    readonly source?: Reference<DocumentReference | Media>;
-}
-/**
- * Information that only applies to packages (not products).
- */
-export interface MedicationKnowledgePackaging {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * A code that defines the specific type of packaging that the medication
-     * can be found in (e.g. blister sleeve, tube, bottle).
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * The number of product units the package would contain if fully loaded.
-     */
-    readonly quantity?: Quantity;
-}
-/**
- * Regulatory information about a medication.
- */
-export interface MedicationKnowledgeRegulatory {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The authority that is specifying the regulations.
-     */
-    readonly regulatoryAuthority?: Reference<Organization>;
-    /**
-     * Specifies if changes are allowed when dispensing a medication from a
-     * regulatory perspective.
-     */
-    readonly substitution?: MedicationKnowledgeRegulatorySubstitution[];
-    /**
-     * Specifies the schedule of a medication in jurisdiction.
-     */
-    readonly schedule?: MedicationKnowledgeRegulatorySchedule[];
-    /**
-     * The maximum number of units of the medication that can be dispensed in
-     * a period.
-     */
-    readonly maxDispense?: MedicationKnowledgeRegulatoryMaxDispense;
-}
-/**
- * The maximum number of units of the medication that can be dispensed in
- * a period.
- */
-export interface MedicationKnowledgeRegulatoryMaxDispense {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The maximum number of units of the medication that can be dispensed.
-     */
-    readonly quantity?: Quantity;
-    /**
-     * The period that applies to the maximum number of units.
-     */
-    readonly period?: Duration;
-}
-/**
- * Specifies the schedule of a medication in jurisdiction.
- */
-export interface MedicationKnowledgeRegulatorySchedule {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * Specifies the specific drug schedule.
-     */
-    readonly schedule?: CodeableConcept;
-}
-/**
- * Specifies if changes are allowed when dispensing a medication from a
- * regulatory perspective.
- */
-export interface MedicationKnowledgeRegulatorySubstitution {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * Specifies the type of substitution allowed.
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Specifies if regulation allows for changes in the medication when
-     * dispensing.
-     */
-    readonly allowed?: boolean;
-}
-/**
- * Associated or related knowledge about a medication.
- */
-export interface MedicationKnowledgeRelatedMedicationKnowledge {
-    /**
-     * Unique id for the element within a resource (for internal references).
-     * This may be any string value that does not contain spaces.
-     */
-    readonly id?: string;
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element. To make the use of extensions
-     * safe and manageable, there is a strict set of governance  applied to
-     * the definition and use of extensions. Though any implementer can
-     * define an extension, there is a set of requirements that SHALL be met
-     * as part of the definition of the extension.
-     */
-    readonly extension?: Extension[];
-    /**
-     * May be used to represent additional information that is not part of
-     * the basic definition of the element and that modifies the
-     * understanding of the element in which it is contained and/or the
-     * understanding of the containing element's descendants. Usually
-     * modifier elements provide negation or qualification. To make the use
-     * of extensions safe and manageable, there is a strict set of governance
-     * applied to the definition and use of extensions. Though any
-     * implementer can define an extension, there is a set of requirements
-     * that SHALL be met as part of the definition of the extension.
-     * Applications processing a resource are required to check for modifier
-     * extensions.
-     *
-     * Modifier extensions SHALL NOT change the meaning of any elements on
-     * Resource or DomainResource (including cannot change the meaning of
-     * modifierExtension itself).
-     */
-    readonly modifierExtension?: Extension[];
-    /**
-     * The category of the associated medication knowledge reference.
-     */
-    readonly type?: CodeableConcept;
-    /**
-     * Associated documentation about the associated medication knowledge.
-     */
-    readonly reference?: Reference<MedicationKnowledge>[];
-}