@kent-tokyo/chematic 0.1.89 → 0.2.0

package/README.md

@@ -96,6 +96,26 @@ const ifg = JSON.parse(identify_functional_groups(mol));
 console.log(ifg); // [{"atoms":[1,2,3],"types":"OC=O"}, ...]
 ```
 
+## Version History
+
+**v0.1.94** (2026-06-12):
+- SA Score corpus expanded: 188 FDA molecules (1415 unique fragments)
+- Enhanced fingerprints: True MHFP, True ERG, path FP with bond types
+- Full multi-sphere CIP stereochemistry for R/S assignment
+- InChI stereo layer round-trip support (tetrahedral and E/Z)
+
+**v0.1.93** (2026-06-12):
+- Full multi-sphere CIP priority rules
+- Correct stereochemistry assignment for complex chiral centers
+
+**v0.1.92** (2026-06-12):
+- InChI stereo layer parsing (tetrahedral `/t` and E/Z `/b`)
+- Path fingerprint with bond type interleaving
+
+**v0.1.91** (2026-06-12):
+- True MHFP (structural fragment hashing)
+- True ERG (Ertl 2017 functional group detection)
+
 ## Building from source
 
 ```sh

package/chematic_wasm.d.ts

@@ -94,6 +94,47 @@ export class DepictOptions {
     set_width(w: number): void;
 }
 
+/**
+ * MinHash LSH index: insert MHFP fingerprints and query by approximate similarity.
+ *
+ * ```js
+ * const idx = new MhfpLshHandle(128);
+ * const i0 = idx.add_smiles("c1ccccc1");    // benzene → index 0
+ * const i1 = idx.add_smiles("Cc1ccccc1");   // toluene → index 1
+ * const hits = JSON.parse(idx.query_json("c1ccccc1", 0.5));
+ * // hits: [{index:0,similarity:1.0}, {index:1,similarity:0.xxx}]
+ * ```
+ */
+export class MhfpLshHandle {
+    free(): void;
+    [Symbol.dispose](): void;
+    /**
+     * Add a molecule by SMILES; returns its 0-based index in the index.
+     */
+    add_smiles(smiles: string): number;
+    /**
+     * True if the index contains no molecules.
+     */
+    is_empty(): boolean;
+    /**
+     * Number of molecules in the index.
+     */
+    len(): number;
+    /**
+     * Create a new LSH index for MHFP fingerprints with `num_hashes` hash lanes.
+     * Default band decomposition: 16 bands × (num_hashes / 16) rows.
+     * `num_hashes` must be a multiple of 16 (e.g. 128).
+     */
+    constructor(num_hashes: number);
+    /**
+     * Query by SMILES for all entries with similarity ≥ threshold.
+     *
+     * Returns a JSON array `[{"index":N,"similarity":0.xxx},...]` sorted by
+     * descending similarity.  Empty array `[]` when nothing qualifies.
+     */
+    query_json(query_smiles: string, threshold: number): string;
+}
+
 /**
  * A handle to a parsed molecule.  Owns the molecule behind an `Rc` so that
  * it can be cheaply cloned on the JS side without copying atom/bond data.
@@ -106,6 +147,12 @@ export class MolHandle {
      * Number of aromatic rings (all ring atoms aromatic).
      */
     aromatic_ring_count(): number;
+    /**
+     * Assign CIP (R/S/E/Z) stereocenters and return JSON.
+     *
+     * Format: `{"centers":[{"atom":0,"code":"R"},{"atom":3,"code":"E"}]}`
+     */
+    assign_cip_json(): string;
     /**
      * Number of heavy atoms (explicit atoms in the graph; does not count implicit H).
      */
@@ -213,6 +260,21 @@ export class MolHandle {
      * Number of non-hydrogen heavy atoms.
      */
     heavy_atom_count(): number;
+    /**
+     * Isotope distribution as JSON.
+     *
+     * Returns `[{"mass":100.0,"abundance":0.9},...]` sorted by mass.
+     * `resolution`: m/z bin width in Da (e.g. `0.1` for nominal, `0.01` for high-res).
+     */
+    isotope_distribution_json(resolution: number): string;
+    /**
+     * Generate IUPAC systematic name for the molecule.
+     *
+     * Returns the name string on success, or an empty string when the
+     * structure is outside the supported naming scope (complex polycyclics,
+     * multi-functional groups, etc.).
+     */
+    iupac_name(): string;
     /**
      * Hall–Kier κ1 shape index.
      */
@@ -233,6 +295,19 @@ export class MolHandle {
      * Returns `true` if the molecule satisfies Lipinski's Rule of Five.
      */
     lipinski_passes(): boolean;
+    /**
+     * LogD (distribution coefficient) at a specific pH.
+     *
+     * Accounts for ionization state: neutral molecules return LogP unchanged,
+     * ionizable molecules are adjusted by log(neutral_fraction).
+     */
+    logd_at_ph(ph: number): number;
+    /**
+     * LogD profile across a pH range as JSON.
+     *
+     * Returns `[{"ph":0.0,"logd":2.5}, ...]` with `steps` evenly-spaced pH points.
+     */
+    logd_profile_json(ph_start: number, ph_end: number, steps: number): string;
     /**
      * Crippen–Wildman octanol/water partition coefficient (LogP).
      */
@@ -307,6 +382,12 @@ export class MolHandle {
      * Quantitative Estimate of Drug-likeness (QED); range [0, 1].
      */
     qed(): number;
+    /**
+     * Randić connectivity index (χ₀).
+     *
+     * χ₀ = Σ 1/√(d_i × d_j) over all bonds, where d is heavy-atom degree.
+     */
+    randic_index(): number;
     /**
      * Returns `true` if the molecule passes the REOS (Rapid Elimination Of Swill) filter.
      */
@@ -344,6 +425,10 @@ export class MolHandle {
      * Wiener topological index (sum of all pairwise shortest-path distances).
      */
     wiener_index(): number;
+    /**
+     * Zagreb index M1: Σ d_i² over all heavy atoms.
+     */
+    zagreb_index_m1(): number;
 }
 
 /**
@@ -905,6 +990,14 @@ export function maxmin_picks_ecfp4_json(smiles_json: string, n: number): string;
  */
 export function mcs_smiles_json(smiles_json: string): string;
 
+/**
+ * MinHash fingerprint (128 hashes) as JSON.
+ *
+ * Returns `{"num_hashes":128,"hashes":[u64,...]}`.
+ * Use `tanimoto_mhfp_smiles` for direct SMILES-to-SMILES similarity.
+ */
+export function mhfp_hashes_json(mol: MolHandle): string;
+
 /**
  * Optimize molecular geometry using DREIDING force field.
  *
@@ -919,6 +1012,15 @@ export function mcs_smiles_json(smiles_json: string): string;
  */
 export function minimize_dreiding_json(mol: MolHandle): string;
 
+/**
+ * MMFF94 partial charges (BCI table, ±0.1e accuracy) as a JSON array of f64.
+ *
+ * Uses Bond Charge Increment (BCI) model (Halgren 1996) for 25 common bond types.
+ * Returns `[q0, q1, ..., qN]` — one value per heavy atom.
+ * Total charge equals the sum of formal charges (charge conserved).
+ */
+export function mmff94_charges_json(mol: MolHandle): string;
+
 /**
  * Find matched molecular pairs in a set of molecules as JSON.
  *
@@ -1442,6 +1544,11 @@ export function tanimoto_fcfp6(a: MolHandle, b: MolHandle): number;
  */
 export function tanimoto_maccs(a: MolHandle, b: MolHandle): number;
 
+/**
+ * Tanimoto-like similarity between two SMILES via MHFP (MinHash Jaccard approximation).
+ */
+export function tanimoto_mhfp_smiles(smi1: string, smi2: string): number;
+
 /**
  * Tanimoto similarity between two molecules given only SMILES strings (ECFP4).
  *
@@ -1513,261 +1620,3 @@ export function whim_getaway_combined_json(mol: MolHandle): string;
  * order) matters more than a canonical form.
  */
 export function write_smiles(mol: MolHandle): string;
-
-export type InitInput = RequestInfo | URL | Response | BufferSource | WebAssembly.Module;
-
-export interface InitOutput {
-    readonly memory: WebAssembly.Memory;
-    readonly __wbg_conformerhandle_free: (a: number, b: number) => void;
-    readonly __wbg_depictoptions_free: (a: number, b: number) => void;
-    readonly __wbg_molhandle_free: (a: number, b: number) => void;
-    readonly add_hydrogens: (a: number) => number;
-    readonly atom_pair_bitvec: (a: number) => [number, number];
-    readonly autocorr_2d_json: (a: number) => [number, number];
-    readonly autocorr_3d_json: (a: number) => [number, number];
-    readonly balance_check_json: (a: number, b: number) => [number, number];
-    readonly brics_fragment_count: (a: number) => number;
-    readonly brics_fragments_json: (a: number) => [number, number];
-    readonly butina_cluster_ecfp4_json: (a: number, b: number, c: number) => [number, number, number, number];
-    readonly canonical_tautomer: (a: number) => number;
-    readonly cdxml_to_smiles_json: (a: number, b: number) => [number, number, number, number];
-    readonly cip_assignments_json: (a: number) => [number, number];
-    readonly conformerhandle_add_generated_conformer: (a: number) => number;
-    readonly conformerhandle_add_minimized_conformer: (a: number) => number;
-    readonly conformerhandle_conformer_count: (a: number) => number;
-    readonly conformerhandle_conformer_rmsd: (a: number, b: number, c: number) => number;
-    readonly conformerhandle_conformer_rmsd_no_align: (a: number, b: number, c: number) => number;
-    readonly conformerhandle_get_conformer_pdb: (a: number, b: number) => [number, number];
-    readonly conformerhandle_mol: (a: number) => number;
-    readonly conformerhandle_new: (a: number, b: number) => [number, number, number];
-    readonly conformerhandle_remove_conformer: (a: number, b: number) => number;
-    readonly coulomb_energy_json: (a: number) => [number, number];
-    readonly cpk_color: (a: number, b: number) => [number, number];
-    readonly depict_data_json: (a: number) => [number, number];
-    readonly depict_data_with_coords_json: (a: number, b: number, c: number) => [number, number];
-    readonly depict_reaction_svg: (a: number, b: number) => [number, number, number, number];
-    readonly depict_svg_grid: (a: number, b: number, c: number) => [number, number];
-    readonly depict_svg_grid_highlighted: (a: number, b: number, c: number, d: number, e: number) => [number, number];
-    readonly depictoptions_new: () => number;
-    readonly depictoptions_set_atom_color: (a: number, b: number, c: number, d: number) => void;
-    readonly depictoptions_set_atom_ids: (a: number, b: number) => void;
-    readonly depictoptions_set_background: (a: number, b: number, c: number) => void;
-    readonly depictoptions_set_dark: (a: number, b: number) => void;
-    readonly depictoptions_set_height: (a: number, b: number) => void;
-    readonly depictoptions_set_highlight_atoms: (a: number, b: number, c: number) => void;
-    readonly depictoptions_set_highlight_bonds: (a: number, b: number, c: number) => void;
-    readonly depictoptions_set_highlight_color: (a: number, b: number, c: number) => void;
-    readonly depictoptions_set_kekulize: (a: number, b: number) => void;
-    readonly depictoptions_set_padding: (a: number, b: number) => void;
-    readonly depictoptions_set_show_atom_indices: (a: number, b: number) => void;
-    readonly depictoptions_set_width: (a: number, b: number) => void;
-    readonly detect_functional_groups: (a: number) => [number, number];
-    readonly dice_ecfp4: (a: number, b: number) => number;
-    readonly dice_ecfp6: (a: number, b: number) => number;
-    readonly dice_maccs: (a: number, b: number) => number;
-    readonly ecfp4_bitvec: (a: number) => [number, number];
-    readonly ecfp4_bitvec_with_chirality: (a: number, b: number) => [number, number];
-    readonly ecfp6_bitvec: (a: number) => [number, number];
-    readonly ecfp6_bitvec_with_chirality: (a: number, b: number) => [number, number];
-    readonly ecfp_bitvec_custom: (a: number, b: number, c: number, d: number) => [number, number];
-    readonly enumerate_library_2way: (a: number, b: number, c: number, d: number, e: number, f: number) => [number, number, number, number];
-    readonly enumerate_stereo_isomers_json: (a: number) => [number, number, number, number];
-    readonly enumerate_tautomers_json: (a: number) => [number, number];
-    readonly estate_indices_json: (a: number) => [number, number];
-    readonly fcfp4_bitvec: (a: number) => [number, number];
-    readonly fcfp6_bitvec: (a: number) => [number, number];
-    readonly find_reaction_center_json: (a: number, b: number) => [number, number];
-    readonly gasteiger_charges_json: (a: number) => [number, number];
-    readonly generate_3d_etkdg_minimized_pdb: (a: number) => [number, number];
-    readonly generate_3d_etkdg_pdb: (a: number) => [number, number];
-    readonly generate_3d_minimized_pdb: (a: number) => [number, number];
-    readonly generate_3d_pdb: (a: number) => [number, number];
-    readonly generic_murcko_scaffold: (a: number) => number;
-    readonly get_atom_info: (a: number, b: number) => [number, number];
-    readonly get_bond_between: (a: number, b: number, c: number) => [number, number];
-    readonly get_bond_info: (a: number, b: number) => [number, number];
-    readonly get_bond_length_json: (a: number, b: number, c: number, d: number) => number;
-    readonly get_descriptors_json: (a: number) => [number, number];
-    readonly get_dihedral_json: (a: number, b: number, c: number, d: number, e: number, f: number) => any;
-    readonly getaway_descriptors_json: (a: number) => [number, number];
-    readonly identify_functional_groups: (a: number) => [number, number];
-    readonly inchi_from_smiles: (a: number, b: number) => [number, number];
-    readonly inchikey_from_smiles: (a: number, b: number) => [number, number];
-    readonly invert_stereocenter_at: (a: number, b: number) => [number, number, number];
-    readonly is_valid_smiles: (a: number, b: number) => number;
-    readonly labute_asa_per_atom_json: (a: number) => [number, number];
-    readonly largest_fragment: (a: number) => number;
-    readonly logp_per_atom_json: (a: number) => [number, number];
-    readonly maccs_bitvec: (a: number) => [number, number];
-    readonly match_smarts_smiles: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly maxmin_picks_ecfp4_json: (a: number, b: number, c: number) => [number, number, number, number];
-    readonly mcs_smiles_json: (a: number, b: number) => [number, number, number, number];
-    readonly minimize_dreiding_json: (a: number) => [number, number];
-    readonly mmp_pairs_json: (a: number, b: number) => [number, number, number, number];
-    readonly mol2_to_smiles: (a: number, b: number) => [number, number];
-    readonly mol_block_coords_json: (a: number, b: number) => [number, number, number, number];
-    readonly mol_block_from_smiles: (a: number, b: number) => [number, number, number, number];
-    readonly mol_from_cdxml: (a: number, b: number) => [number, number, number];
-    readonly mol_from_cml: (a: number, b: number) => [number, number, number];
-    readonly mol_from_pdb: (a: number, b: number) => number;
-    readonly mol_from_sdf_block: (a: number, b: number) => [number, number, number];
-    readonly mol_from_v3000_block: (a: number, b: number) => [number, number, number];
-    readonly mol_from_xyz: (a: number, b: number) => [number, number, number];
-    readonly mol_next_atom_idx: (a: number) => number;
-    readonly mol_with_atom_added: (a: number, b: number, c: number) => [number, number, number];
-    readonly mol_with_atom_charge: (a: number, b: number, c: number) => [number, number, number];
-    readonly mol_with_atom_element: (a: number, b: number, c: number, d: number) => [number, number, number];
-    readonly mol_with_atom_removed: (a: number, b: number) => [number, number, number];
-    readonly mol_with_bond_added: (a: number, b: number, c: number, d: number) => [number, number, number];
-    readonly mol_with_bond_removed: (a: number, b: number) => [number, number, number];
-    readonly molhandle_aromatic_ring_count: (a: number) => number;
-    readonly molhandle_bertz_ct: (a: number) => number;
-    readonly molhandle_bond_count: (a: number) => number;
-    readonly molhandle_canonical_smiles: (a: number) => [number, number];
-    readonly molhandle_chi0: (a: number) => number;
-    readonly molhandle_chi0v: (a: number) => number;
-    readonly molhandle_chi1: (a: number) => number;
-    readonly molhandle_chi1v: (a: number) => number;
-    readonly molhandle_chi2: (a: number) => number;
-    readonly molhandle_chi2v: (a: number) => number;
-    readonly molhandle_chi3: (a: number) => number;
-    readonly molhandle_chi3v: (a: number) => number;
-    readonly molhandle_chi4: (a: number) => number;
-    readonly molhandle_chi4v: (a: number) => number;
-    readonly molhandle_depict_png: (a: number) => [number, number];
-    readonly molhandle_depict_svg: (a: number) => [number, number];
-    readonly molhandle_depict_svg_opts: (a: number, b: number) => [number, number];
-    readonly molhandle_egan_passes: (a: number) => number;
-    readonly molhandle_exact_mass: (a: number) => number;
-    readonly molhandle_formal_charge_sum: (a: number) => number;
-    readonly molhandle_formula: (a: number) => [number, number];
-    readonly molhandle_fsp3: (a: number) => number;
-    readonly molhandle_ghose_passes: (a: number) => number;
-    readonly molhandle_hba_count: (a: number) => number;
-    readonly molhandle_hbd_count: (a: number) => number;
-    readonly molhandle_heavy_atom_count: (a: number) => number;
-    readonly molhandle_kappa1: (a: number) => number;
-    readonly molhandle_kappa2: (a: number) => number;
-    readonly molhandle_kappa3: (a: number) => number;
-    readonly molhandle_labute_asa: (a: number) => number;
-    readonly molhandle_lipinski_passes: (a: number) => number;
-    readonly molhandle_logp_crippen: (a: number) => number;
-    readonly molhandle_max_estate: (a: number) => number;
-    readonly molhandle_min_estate: (a: number) => number;
-    readonly molhandle_molar_refractivity: (a: number) => number;
-    readonly molhandle_molecular_weight: (a: number) => number;
-    readonly molhandle_morgan_fp_counts_json: (a: number, b: number) => [number, number];
-    readonly molhandle_num_aliphatic_heterocycles: (a: number) => number;
-    readonly molhandle_num_aliphatic_rings: (a: number) => number;
-    readonly molhandle_num_aromatic_heterocycles: (a: number) => number;
-    readonly molhandle_num_bridgehead_atoms: (a: number) => number;
-    readonly molhandle_num_heteroatoms: (a: number) => number;
-    readonly molhandle_num_saturated_heterocycles: (a: number) => number;
-    readonly molhandle_num_saturated_rings: (a: number) => number;
-    readonly molhandle_num_spiro_atoms: (a: number) => number;
-    readonly molhandle_num_stereocenters: (a: number) => number;
-    readonly molhandle_num_unspecified_stereocenters: (a: number) => number;
-    readonly molhandle_pains_passes: (a: number) => number;
-    readonly molhandle_qed: (a: number) => number;
-    readonly molhandle_reos_passes: (a: number) => number;
-    readonly molhandle_ring_count: (a: number) => number;
-    readonly molhandle_rotatable_bond_count: (a: number) => number;
-    readonly molhandle_sum_estate: (a: number) => number;
-    readonly molhandle_to_inchi: (a: number) => [number, number];
-    readonly molhandle_to_inchikey: (a: number) => [number, number];
-    readonly molhandle_tpsa: (a: number) => number;
-    readonly molhandle_veber_passes: (a: number) => number;
-    readonly molhandle_wiener_index: (a: number) => number;
-    readonly mqn_json: (a: number) => [number, number];
-    readonly mr_per_atom_json: (a: number) => [number, number];
-    readonly murcko_scaffold: (a: number) => number;
-    readonly nearest_neighbors_json: (a: number, b: number, c: number, d: number, e: number) => [number, number];
-    readonly neutralize_charges: (a: number) => number;
-    readonly normalize_cxsmiles: (a: number, b: number) => [number, number, number, number];
-    readonly normalize_reaction_smiles: (a: number, b: number) => [number, number, number, number];
-    readonly pains_matches_json: (a: number) => [number, number];
-    readonly parse_cxsmarts_json: (a: number, b: number) => [number, number, number, number];
-    readonly parse_cxsmiles_json: (a: number, b: number) => [number, number, number, number];
-    readonly parse_smiles: (a: number, b: number) => [number, number, number];
-    readonly peoe_vsa_json: (a: number) => [number, number];
-    readonly pharmacophore_features_json: (a: number) => [number, number];
-    readonly pharmacophore_fp_2d_summary: (a: number) => [number, number];
-    readonly pharmacophore_fp_3d_summary: (a: number) => [number, number];
-    readonly random_smiles_json: (a: number, b: number, c: number, d: bigint) => [number, number, number, number];
-    readonly remove_hydrogens: (a: number) => number;
-    readonly rgroup_decompose_json: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly ring_families_json: (a: number) => [number, number, number, number];
-    readonly run_md_json: (a: number, b: number, c: number) => [number, number];
-    readonly run_reactants: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly sa_score: (a: number) => number;
-    readonly sdf_from_records_json: (a: number, b: number, c: number, d: number, e: number, f: number) => [number, number, number, number];
-    readonly sdf_to_records_json: (a: number, b: number) => [number, number];
-    readonly sdf_to_smiles_json: (a: number, b: number) => [number, number];
-    readonly set_dihedral_json: (a: number, b: number, c: number, d: number, e: number, f: number, g: number) => [number, number, number, number];
-    readonly shape_descriptors_json: (a: number) => [number, number];
-    readonly slogp_vsa_json: (a: number) => [number, number];
-    readonly smarts_match_atoms: (a: number, b: number, c: number) => [number, number, number, number];
-    readonly smarts_match_atoms_with_chirality: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly smiles_array_to_sdf: (a: number, b: number) => [number, number, number, number];
-    readonly smiles_to_mol2: (a: number, b: number) => [number, number];
-    readonly smiles_to_svg_highlighted: (a: number, b: number, c: number, d: number, e: number, f: number, g: number, h: number) => [number, number, number, number];
-    readonly smr_vsa_json: (a: number) => [number, number];
-    readonly sssr_rings_json: (a: number) => [number, number];
-    readonly standardize_smiles: (a: number, b: number) => [number, number];
-    readonly standardize_smiles_report_json: (a: number, b: number, c: number, d: number, e: number, f: number) => [number, number];
-    readonly tanimoto_atom_pair: (a: number, b: number) => number;
-    readonly tanimoto_ecfp4: (a: number, b: number) => number;
-    readonly tanimoto_ecfp6: (a: number, b: number) => number;
-    readonly tanimoto_fcfp4: (a: number, b: number) => number;
-    readonly tanimoto_fcfp6: (a: number, b: number) => number;
-    readonly tanimoto_maccs: (a: number, b: number) => number;
-    readonly tanimoto_smiles: (a: number, b: number, c: number, d: number) => [number, number, number];
-    readonly tanimoto_topo_path: (a: number, b: number) => number;
-    readonly tanimoto_torsion: (a: number, b: number) => number;
-    readonly to_cml: (a: number) => [number, number];
-    readonly to_mol_block: (a: number) => [number, number];
-    readonly to_mol_v3000_block: (a: number) => [number, number];
-    readonly to_xyz: (a: number) => [number, number];
-    readonly torsion_bitvec: (a: number) => [number, number];
-    readonly whim_descriptors_json: (a: number) => [number, number];
-    readonly whim_getaway_combined_json: (a: number) => [number, number];
-    readonly write_smiles: (a: number) => [number, number];
-    readonly start: () => void;
-    readonly molhandle_atom_count: (a: number) => number;
-    readonly compare_molecules_batch_json: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly compare_molecules_json: (a: number, b: number, c: number, d: number) => [number, number, number, number];
-    readonly generate_3d_from_smiles: (a: number, b: number) => [number, number, number, number];
-    readonly generate_3d_optimized_pdb: (a: number, b: number) => [number, number, number, number];
-    readonly molecule_report_json: (a: number, b: number) => [number, number, number, number];
-    readonly screen_smiles_json: (a: number, b: number, c: number, d: number) => [number, number];
-    readonly __wbindgen_malloc: (a: number, b: number) => number;
-    readonly __wbindgen_realloc: (a: number, b: number, c: number, d: number) => number;
-    readonly __wbindgen_free: (a: number, b: number, c: number) => void;
-    readonly __wbindgen_exn_store: (a: number) => void;
-    readonly __externref_table_alloc: () => number;
-    readonly __wbindgen_externrefs: WebAssembly.Table;
-    readonly __externref_table_dealloc: (a: number) => void;
-    readonly __wbindgen_start: () => void;
-}
-
-export type SyncInitInput = BufferSource | WebAssembly.Module;
-
-/**
- * Instantiates the given `module`, which can either be bytes or
- * a precompiled `WebAssembly.Module`.
- *
- * @param {{ module: SyncInitInput }} module - Passing `SyncInitInput` directly is deprecated.
- *
- * @returns {InitOutput}
- */
-export function initSync(module: { module: SyncInitInput } | SyncInitInput): InitOutput;
-
-/**
- * If `module_or_path` is {RequestInfo} or {URL}, makes a request and
- * for everything else, calls `WebAssembly.instantiate` directly.
- *
- * @param {{ module_or_path: InitInput | Promise<InitInput> }} module_or_path - Passing `InitInput` directly is deprecated.
- *
- * @returns {Promise<InitOutput>}
- */
-export default function __wbg_init (module_or_path?: { module_or_path: InitInput | Promise<InitInput> } | InitInput | Promise<InitInput>): Promise<InitOutput>;