@jbrowse/plugin-variants 2.3.1 → 2.3.2

package/dist/VcfTabixAdapter/VcfFeature.js.map

@@ -1 +0,0 @@
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package/esm/VcfTabixAdapter/VcfFeature.js

@@ -1,184 +0,0 @@
-import { parseBreakend } from '@gmod/vcf';
-export default class VCFFeature {
-    // eslint-disable-next-line @typescript-eslint/no-explicit-any
-    constructor(args) {
-        this.variant = args.variant;
-        this.parser = args.parser;
-        this.data = this.dataFromVariant(this.variant);
-        this._id = args.id;
-    }
-    // eslint-disable-next-line @typescript-eslint/no-explicit-any
-    get(field) {
-        return field === 'samples'
-            ? this.variant.SAMPLES
-            : this.data[field] || this.variant[field];
-    }
-    set() { }
-    parent() {
-        return undefined;
-    }
-    children() {
-        return undefined;
-    }
-    tags() {
-        const t = [
-            ...Object.keys(this.data),
-            ...Object.keys(this.variant),
-            'samples',
-        ];
-        return t;
-    }
-    id() {
-        return this._id;
-    }
-    dataFromVariant(variant) {
-        const { REF, ALT, POS, CHROM, INFO, ID } = variant;
-        const start = POS - 1;
-        const [SO_term, description] = this._getSOTermAndDescription(REF, ALT);
-        const isTRA = ALT === null || ALT === void 0 ? void 0 : ALT.some(f => f === '<TRA>');
-        const isSymbolic = ALT === null || ALT === void 0 ? void 0 : ALT.some(f => f.indexOf('<') !== -1);
-        return {
-            refName: CHROM,
-            start,
-            end: isSymbolic && INFO.END && !isTRA ? +INFO.END[0] : start + REF.length,
-            description,
-            type: SO_term,
-            name: ID === null || ID === void 0 ? void 0 : ID.join(','),
-            aliases: ID && ID.length > 1 ? variant.ID.slice(1) : undefined,
-        };
-    }
-    /**
-     * Get a sequence ontology (SO) term that describes the variant type
-     */
-    _getSOTermAndDescription(ref, alt) {
-        // it's just a remark if there are no alternate alleles
-        if (!alt || alt.length === 0) {
-            return ['remark', 'no alternative alleles'];
-        }
-        const soTerms = new Set();
-        let descriptions = new Set();
-        alt.forEach(a => {
-            let [soTerm, description] = this._getSOAndDescFromAltDefs(ref, a);
-            if (!soTerm) {
-                ;
-                [soTerm, description] = this._getSOAndDescByExamination(ref, a);
-            }
-            if (soTerm && description) {
-                soTerms.add(soTerm);
-                descriptions.add(description);
-            }
-        });
-        // Combine descriptions like ["SNV G -> A", "SNV G -> T"] to ["SNV G -> A,T"]
-        if (descriptions.size > 1) {
-            const prefixes = new Set([...descriptions].map(desc => {
-                const prefix = desc.split('->');
-                return prefix[1] ? prefix[0] : desc;
-            }));
-            const new_descs = [...prefixes].map(prefix => {
-                const suffixes = [...descriptions]
-                    .map(desc => {
-                    const pref = desc.split('-> ');
-                    return pref[1] && pref[0] === prefix ? pref[1] : '';
-                })
-                    .filter(f => !!f);
-                return suffixes.length
-                    ? prefix + '-> ' + suffixes.join(',')
-                    : [...descriptions].join(',');
-            });
-            descriptions = new Set(new_descs);
-        }
-        if (soTerms.size) {
-            return [[...soTerms].join(','), [...descriptions].join(',')];
-        }
-        return [undefined, undefined];
-    }
-    _getSOAndDescFromAltDefs(ref, alt) {
-        if (typeof alt === 'string' && !alt.startsWith('<')) {
-            return [undefined, undefined];
-        }
-        // look for a definition with an SO type for this
-        let soTerm = VCFFeature._altTypeToSO[alt];
-        // if no SO term but ALT is in metadata, assume sequence_variant
-        if (!soTerm && this.parser.getMetadata('ALT', alt)) {
-            soTerm = 'sequence_variant';
-        }
-        if (soTerm) {
-            return [soTerm, alt];
-        }
-        // try to look for a definition for a parent term if we can
-        const modAlt = alt.split(':');
-        if (modAlt.length > 1) {
-            return this._getSOAndDescFromAltDefs(ref, `<${modAlt.slice(0, modAlt.length - 1).join(':')}>`);
-        }
-        // no parent
-        return [undefined, undefined];
-    }
-    // note: term SNV is used instead of SNP because SO definition of SNP says
-    // abundance must be at least 1% in population, and can't be sure we meet
-    // that
-    _getSOAndDescByExamination(ref, alt) {
-        const bnd = parseBreakend(alt);
-        if (bnd) {
-            return ['breakend', alt];
-        }
-        else if (ref.length === 1 && alt.length === 1) {
-            return ['SNV', this._makeDescriptionString('SNV', ref, alt)];
-        }
-        else if (alt === '<INS>') {
-            return ['insertion', alt];
-        }
-        else if (alt === '<DEL>') {
-            return ['deletion', alt];
-        }
-        else if (alt === '<INV>') {
-            return ['deletion', alt];
-        }
-        else if (alt === '<TRA>') {
-            return ['translocation', alt];
-        }
-        else if (alt.includes('<')) {
-            return ['sv', alt];
-        }
-        else if (ref.length === alt.length) {
-            if (ref.split('').reverse().join('') === alt) {
-                return ['inversion', this._makeDescriptionString('inversion', ref, alt)];
-            }
-            return [
-                'substitution',
-                this._makeDescriptionString('substitution', ref, alt),
-            ];
-        }
-        else if (ref.length <= alt.length) {
-            return ['insertion', this._makeDescriptionString('insertion', ref, alt)];
-        }
-        else if (ref.length > alt.length) {
-            return ['deletion', this._makeDescriptionString('deletion', ref, alt)];
-        }
-        return ['indel', this._makeDescriptionString('indel', ref, alt)];
-    }
-    _makeDescriptionString(soTerm, ref, alt) {
-        return `${soTerm} ${ref} -> ${alt}`;
-    }
-    // eslint-disable-next-line @typescript-eslint/no-explicit-any
-    toJSON() {
-        return {
-            uniqueId: this._id,
-            ...this.variant,
-            ...this.data,
-            samples: this.variant.SAMPLES,
-        };
-    }
-}
-VCFFeature._altTypeToSO = {
-    DEL: 'deletion',
-    INS: 'insertion',
-    DUP: 'duplication',
-    INV: 'inversion',
-    INVDUP: 'inverted duplication',
-    CNV: 'copy_number_variation',
-    TRA: 'translocation',
-    'DUP:TANDEM': 'tandem_duplication',
-    NON_REF: 'sequence_variant',
-    '*': 'sequence_variant',
-};
-//# sourceMappingURL=VcfFeature.js.map

package/esm/VcfTabixAdapter/VcfFeature.js.map

@@ -1 +0,0 @@
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package/src/VcfTabixAdapter/VcfFeature.test.ts

@@ -1,118 +0,0 @@
-import VcfParser from '@gmod/vcf'
-import VcfFeature from './VcfFeature'
-
-test('test usage of the VcfFeature', () => {
-  const parser = new VcfParser({
-    header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-  })
-  const line = `lcl|Scaffald_1\t80465\trs118266897\tR\tA\t29\tPASS\tNS=3;0,14;AF=0.5;DB;112;PG2.1`
-
-  const variant = parser.parseLine(line)
-
-  const f = new VcfFeature({
-    parser,
-    variant,
-    id: 'myuniqueid',
-  })
-  expect(f.id()).toEqual('myuniqueid')
-  expect(f.get('name')).toEqual('rs118266897')
-})
-
-test('try INS feature with END less than start', () => {
-  const parser = new VcfParser({
-    header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-  })
-  const line = `chr1\t100\trs123\tR\tA\t29\tPASS\tEND=1;SVTYPE=INS`
-
-  const variant = parser.parseLine(line)
-
-  const f = new VcfFeature({
-    parser,
-    variant,
-    id: 'myuniqueid',
-  })
-  expect(f.id()).toEqual('myuniqueid')
-  expect(f.get('start')).toEqual(99)
-  expect(f.get('end')).toEqual(100)
-})
-
-test('try DEL feature with END info field valid', () => {
-  const parser = new VcfParser({
-    header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-  })
-  const line = `chr1\t100\trs123\tR\t<DEL>\t29\tPASS\tEND=1000;SVTYPE=DEL`
-
-  const variant = parser.parseLine(line)
-
-  const f = new VcfFeature({
-    parser,
-    variant,
-    id: 'myuniqueid',
-  })
-  expect(f.id()).toEqual('myuniqueid')
-  expect(f.get('start')).toEqual(99)
-  expect(f.get('end')).toEqual(1000)
-})
-
-describe('test SV description', () => {
-  it('multiple SVs', () => {
-    const parser = new VcfParser({
-      header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-    })
-    const line = `chr1\t100\trs123\tR\t<INVDUP>,<INV>\t29\tPASS\tEND=1000;SVTYPE=DEL`
-
-    const variant = parser.parseLine(line)
-
-    const f = new VcfFeature({
-      parser,
-      variant,
-      id: 'myuniqueid',
-    })
-    expect(f.get('description')).toEqual('<INVDUP>,<INV>')
-  })
-  it('BND', () => {
-    const parser = new VcfParser({
-      header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-    })
-    const line = `chr1\t100\trs123\tR\tG[ctgA:34200[\t29\tPASS\tEND=1000;SVTYPE=BND`
-
-    const variant = parser.parseLine(line)
-
-    const f = new VcfFeature({
-      parser,
-      variant,
-      id: 'myuniqueid',
-    })
-    expect(f.get('description')).toEqual('G[ctgA:34200[')
-  })
-  it('multiple BND', () => {
-    const parser = new VcfParser({
-      header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-    })
-    const line = `chr1\t100\trs123\tR\tG[ctgA:34200[,G[ctgA:44200[\t29\tPASS\tEND=1000;SVTYPE=BND`
-
-    const variant = parser.parseLine(line)
-
-    const f = new VcfFeature({
-      parser,
-      variant,
-      id: 'myuniqueid',
-    })
-    expect(f.get('description')).toEqual('G[ctgA:34200[,G[ctgA:44200[')
-  })
-  it('multiple SNV', () => {
-    const parser = new VcfParser({
-      header: `#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT\tBAMs/caudaus.sorted.sam`,
-    })
-    const line = `chr1\t100\trs123\tG\tA,C\t29\tPASS\tHELLO=world`
-
-    const variant = parser.parseLine(line)
-
-    const f = new VcfFeature({
-      parser,
-      variant,
-      id: 'myuniqueid',
-    })
-    expect(f.get('description')).toEqual('SNV G -> A,C')
-  })
-})

package/src/VcfTabixAdapter/VcfFeature.ts

@@ -1,250 +0,0 @@
-import { Feature } from '@jbrowse/core/util/simpleFeature'
-import { parseBreakend } from '@gmod/vcf'
-
-/* eslint-disable no-underscore-dangle */
-
-/**
- * VCF Feature creation with lazy genotype evaluation.
- */
-interface Samples {
-  [key: string]: {
-    [key: string]: { values: string[] | number[] | null }
-  }
-}
-
-interface FeatureData {
-  [key: string]: unknown
-  refName: string
-  start: number
-  end: number
-  description?: string
-  type?: string
-  name?: string
-  aliases?: string[]
-  samples?: Samples
-}
-
-export default class VCFFeature implements Feature {
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  private variant: any
-
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  private parser: any
-
-  private data: FeatureData
-
-  private _id: string
-
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  constructor(args: { variant: any; parser: any; id: string }) {
-    this.variant = args.variant
-    this.parser = args.parser
-    this.data = this.dataFromVariant(this.variant)
-    this._id = args.id
-  }
-
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  get(field: string): any {
-    return field === 'samples'
-      ? this.variant.SAMPLES
-      : this.data[field] || this.variant[field]
-  }
-
-  set(): void {}
-
-  parent(): undefined {
-    return undefined
-  }
-
-  children(): undefined {
-    return undefined
-  }
-
-  tags(): string[] {
-    const t = [
-      ...Object.keys(this.data),
-      ...Object.keys(this.variant),
-      'samples',
-    ]
-    return t
-  }
-
-  id(): string {
-    return this._id
-  }
-
-  dataFromVariant(variant: {
-    REF: string
-    POS: number
-    ALT: string[]
-    CHROM: string
-    INFO: any // eslint-disable-line @typescript-eslint/no-explicit-any
-    ID: string[]
-  }): FeatureData {
-    const { REF, ALT, POS, CHROM, INFO, ID } = variant
-    const start = POS - 1
-    const [SO_term, description] = this._getSOTermAndDescription(REF, ALT)
-    const isTRA = ALT?.some(f => f === '<TRA>')
-    const isSymbolic = ALT?.some(f => f.indexOf('<') !== -1)
-
-    return {
-      refName: CHROM,
-      start,
-      end: isSymbolic && INFO.END && !isTRA ? +INFO.END[0] : start + REF.length,
-      description,
-      type: SO_term,
-      name: ID?.join(','),
-      aliases: ID && ID.length > 1 ? variant.ID.slice(1) : undefined,
-    }
-  }
-
-  /**
-   * Get a sequence ontology (SO) term that describes the variant type
-   */
-  _getSOTermAndDescription(
-    ref: string,
-    alt: string[],
-  ): [string, string] | [undefined, undefined] {
-    // it's just a remark if there are no alternate alleles
-    if (!alt || alt.length === 0) {
-      return ['remark', 'no alternative alleles']
-    }
-
-    const soTerms = new Set<string>()
-    let descriptions = new Set<string>()
-    alt.forEach(a => {
-      let [soTerm, description] = this._getSOAndDescFromAltDefs(ref, a)
-
-      if (!soTerm) {
-        ;[soTerm, description] = this._getSOAndDescByExamination(ref, a)
-      }
-      if (soTerm && description) {
-        soTerms.add(soTerm)
-        descriptions.add(description)
-      }
-    })
-
-    // Combine descriptions like ["SNV G -> A", "SNV G -> T"] to ["SNV G -> A,T"]
-    if (descriptions.size > 1) {
-      const prefixes = new Set(
-        [...descriptions].map(desc => {
-          const prefix = desc.split('->')
-          return prefix[1] ? prefix[0] : desc
-        }),
-      )
-
-      const new_descs = [...prefixes].map(prefix => {
-        const suffixes = [...descriptions]
-          .map(desc => {
-            const pref = desc.split('-> ')
-            return pref[1] && pref[0] === prefix ? pref[1] : ''
-          })
-          .filter(f => !!f)
-
-        return suffixes.length
-          ? prefix + '-> ' + suffixes.join(',')
-          : [...descriptions].join(',')
-      })
-
-      descriptions = new Set(new_descs)
-    }
-    if (soTerms.size) {
-      return [[...soTerms].join(','), [...descriptions].join(',')]
-    }
-    return [undefined, undefined]
-  }
-
-  static _altTypeToSO: { [key: string]: string | undefined } = {
-    DEL: 'deletion',
-    INS: 'insertion',
-    DUP: 'duplication',
-    INV: 'inversion',
-    INVDUP: 'inverted duplication',
-    CNV: 'copy_number_variation',
-    TRA: 'translocation',
-    'DUP:TANDEM': 'tandem_duplication',
-    NON_REF: 'sequence_variant',
-    '*': 'sequence_variant',
-  }
-
-  _getSOAndDescFromAltDefs(
-    ref: string,
-    alt: string,
-  ): [string, string] | [undefined, undefined] {
-    if (typeof alt === 'string' && !alt.startsWith('<')) {
-      return [undefined, undefined]
-    }
-
-    // look for a definition with an SO type for this
-    let soTerm = VCFFeature._altTypeToSO[alt]
-    // if no SO term but ALT is in metadata, assume sequence_variant
-    if (!soTerm && this.parser.getMetadata('ALT', alt)) {
-      soTerm = 'sequence_variant'
-    }
-    if (soTerm) {
-      return [soTerm, alt]
-    }
-
-    // try to look for a definition for a parent term if we can
-    const modAlt = alt.split(':')
-    if (modAlt.length > 1) {
-      return this._getSOAndDescFromAltDefs(
-        ref,
-        `<${modAlt.slice(0, modAlt.length - 1).join(':')}>`,
-      )
-    }
-
-    // no parent
-    return [undefined, undefined]
-  }
-
-  // note: term SNV is used instead of SNP because SO definition of SNP says
-  // abundance must be at least 1% in population, and can't be sure we meet
-  // that
-  _getSOAndDescByExamination(ref: string, alt: string): [string, string] {
-    const bnd = parseBreakend(alt)
-    if (bnd) {
-      return ['breakend', alt]
-    } else if (ref.length === 1 && alt.length === 1) {
-      return ['SNV', this._makeDescriptionString('SNV', ref, alt)]
-    } else if (alt === '<INS>') {
-      return ['insertion', alt]
-    } else if (alt === '<DEL>') {
-      return ['deletion', alt]
-    } else if (alt === '<INV>') {
-      return ['deletion', alt]
-    } else if (alt === '<TRA>') {
-      return ['translocation', alt]
-    } else if (alt.includes('<')) {
-      return ['sv', alt]
-    } else if (ref.length === alt.length) {
-      if (ref.split('').reverse().join('') === alt) {
-        return ['inversion', this._makeDescriptionString('inversion', ref, alt)]
-      }
-      return [
-        'substitution',
-        this._makeDescriptionString('substitution', ref, alt),
-      ]
-    } else if (ref.length <= alt.length) {
-      return ['insertion', this._makeDescriptionString('insertion', ref, alt)]
-    } else if (ref.length > alt.length) {
-      return ['deletion', this._makeDescriptionString('deletion', ref, alt)]
-    }
-
-    return ['indel', this._makeDescriptionString('indel', ref, alt)]
-  }
-
-  _makeDescriptionString(soTerm: string, ref: string, alt: string): string {
-    return `${soTerm} ${ref} -> ${alt}`
-  }
-
-  // eslint-disable-next-line @typescript-eslint/no-explicit-any
-  toJSON(): any {
-    return {
-      uniqueId: this._id,
-      ...this.variant,
-      ...this.data,
-      samples: this.variant.SAMPLES,
-    }
-  }
-}