@jbrowse/plugin-sequence 1.6.9 → 1.7.3

package/dist/plugin-sequence.esm.js

@@ -1,2561 +0,0 @@
-import AdapterType from '@jbrowse/core/pluggableElementTypes/AdapterType';
-import { createBaseTrackModel } from '@jbrowse/core/pluggableElementTypes/models';
-import FeatureRendererType from '@jbrowse/core/pluggableElementTypes/renderers/FeatureRendererType';
-import TrackType from '@jbrowse/core/pluggableElementTypes/TrackType';
-import Plugin from '@jbrowse/core/Plugin';
-import { BaseLinearDisplay, BaseLinearDisplayComponent } from '@jbrowse/plugin-linear-genome-view';
-import { getFileName, makeIndex } from '@jbrowse/core/util/tracks';
-import { ConfigurationSchema, ConfigurationReference, readConfObject } from '@jbrowse/core/configuration';
-import React from 'react';
-import { contrastingTextColor } from '@jbrowse/core/util/color';
-import { createJBrowseTheme } from '@jbrowse/core/ui';
-import { observer } from 'mobx-react';
-import { generateCodonTable, defaultCodonTable, complement, revcom, defaultStarts, defaultStops, bpSpanPx, getContainingView } from '@jbrowse/core/util';
-import { types } from 'mobx-state-tree';
-import { BaseFeatureDataAdapter, BaseSequenceAdapter, BaseAdapter } from '@jbrowse/core/data_adapters/BaseAdapter';
-import { ObservableCreate } from '@jbrowse/core/util/rxjs';
-import SimpleFeature from '@jbrowse/core/util/simpleFeature';
-import { toArray } from 'rxjs/operators';
-import { openLocation } from '@jbrowse/core/util/io';
-import { TwoBitFile } from '@gmod/twobit';
-import { IndexedFasta, BgzipIndexedFasta } from '@gmod/indexedfasta';
-import AbortablePromiseCache from 'abortable-promise-cache';
-import LRU from '@jbrowse/core/util/QuickLRU';
-
-function ownKeys(object, enumerableOnly) {
-  var keys = Object.keys(object);
-
-  if (Object.getOwnPropertySymbols) {
-    var symbols = Object.getOwnPropertySymbols(object);
-    enumerableOnly && (symbols = symbols.filter(function (sym) {
-      return Object.getOwnPropertyDescriptor(object, sym).enumerable;
-    })), keys.push.apply(keys, symbols);
-  }
-
-  return keys;
-}
-
-function _objectSpread2(target) {
-  for (var i = 1; i < arguments.length; i++) {
-    var source = null != arguments[i] ? arguments[i] : {};
-    i % 2 ? ownKeys(Object(source), !0).forEach(function (key) {
-      _defineProperty(target, key, source[key]);
-    }) : Object.getOwnPropertyDescriptors ? Object.defineProperties(target, Object.getOwnPropertyDescriptors(source)) : ownKeys(Object(source)).forEach(function (key) {
-      Object.defineProperty(target, key, Object.getOwnPropertyDescriptor(source, key));
-    });
-  }
-
-  return target;
-}
-
-function asyncGeneratorStep(gen, resolve, reject, _next, _throw, key, arg) {
-  try {
-    var info = gen[key](arg);
-    var value = info.value;
-  } catch (error) {
-    reject(error);
-    return;
-  }
-
-  if (info.done) {
-    resolve(value);
-  } else {
-    Promise.resolve(value).then(_next, _throw);
-  }
-}
-
-function _asyncToGenerator(fn) {
-  return function () {
-    var self = this,
-        args = arguments;
-    return new Promise(function (resolve, reject) {
-      var gen = fn.apply(self, args);
-
-      function _next(value) {
-        asyncGeneratorStep(gen, resolve, reject, _next, _throw, "next", value);
-      }
-
-      function _throw(err) {
-        asyncGeneratorStep(gen, resolve, reject, _next, _throw, "throw", err);
-      }
-
-      _next(undefined);
-    });
-  };
-}
-
-function _classCallCheck(instance, Constructor) {
-  if (!(instance instanceof Constructor)) {
-    throw new TypeError("Cannot call a class as a function");
-  }
-}
-
-function _defineProperties(target, props) {
-  for (var i = 0; i < props.length; i++) {
-    var descriptor = props[i];
-    descriptor.enumerable = descriptor.enumerable || false;
-    descriptor.configurable = true;
-    if ("value" in descriptor) descriptor.writable = true;
-    Object.defineProperty(target, descriptor.key, descriptor);
-  }
-}
-
-function _createClass(Constructor, protoProps, staticProps) {
-  if (protoProps) _defineProperties(Constructor.prototype, protoProps);
-  if (staticProps) _defineProperties(Constructor, staticProps);
-  Object.defineProperty(Constructor, "prototype", {
-    writable: false
-  });
-  return Constructor;
-}
-
-function _defineProperty(obj, key, value) {
-  if (key in obj) {
-    Object.defineProperty(obj, key, {
-      value: value,
-      enumerable: true,
-      configurable: true,
-      writable: true
-    });
-  } else {
-    obj[key] = value;
-  }
-
-  return obj;
-}
-
-function _inherits(subClass, superClass) {
-  if (typeof superClass !== "function" && superClass !== null) {
-    throw new TypeError("Super expression must either be null or a function");
-  }
-
-  subClass.prototype = Object.create(superClass && superClass.prototype, {
-    constructor: {
-      value: subClass,
-      writable: true,
-      configurable: true
-    }
-  });
-  Object.defineProperty(subClass, "prototype", {
-    writable: false
-  });
-  if (superClass) _setPrototypeOf(subClass, superClass);
-}
-
-function _getPrototypeOf(o) {
-  _getPrototypeOf = Object.setPrototypeOf ? Object.getPrototypeOf : function _getPrototypeOf(o) {
-    return o.__proto__ || Object.getPrototypeOf(o);
-  };
-  return _getPrototypeOf(o);
-}
-
-function _setPrototypeOf(o, p) {
-  _setPrototypeOf = Object.setPrototypeOf || function _setPrototypeOf(o, p) {
-    o.__proto__ = p;
-    return o;
-  };
-
-  return _setPrototypeOf(o, p);
-}
-
-function _isNativeReflectConstruct() {
-  if (typeof Reflect === "undefined" || !Reflect.construct) return false;
-  if (Reflect.construct.sham) return false;
-  if (typeof Proxy === "function") return true;
-
-  try {
-    Boolean.prototype.valueOf.call(Reflect.construct(Boolean, [], function () {}));
-    return true;
-  } catch (e) {
-    return false;
-  }
-}
-
-function _assertThisInitialized(self) {
-  if (self === void 0) {
-    throw new ReferenceError("this hasn't been initialised - super() hasn't been called");
-  }
-
-  return self;
-}
-
-function _possibleConstructorReturn(self, call) {
-  if (call && (typeof call === "object" || typeof call === "function")) {
-    return call;
-  } else if (call !== void 0) {
-    throw new TypeError("Derived constructors may only return object or undefined");
-  }
-
-  return _assertThisInitialized(self);
-}
-
-function _createSuper(Derived) {
-  var hasNativeReflectConstruct = _isNativeReflectConstruct();
-
-  return function _createSuperInternal() {
-    var Super = _getPrototypeOf(Derived),
-        result;
-
-    if (hasNativeReflectConstruct) {
-      var NewTarget = _getPrototypeOf(this).constructor;
-
-      result = Reflect.construct(Super, arguments, NewTarget);
-    } else {
-      result = Super.apply(this, arguments);
-    }
-
-    return _possibleConstructorReturn(this, result);
-  };
-}
-
-function _slicedToArray(arr, i) {
-  return _arrayWithHoles(arr) || _iterableToArrayLimit(arr, i) || _unsupportedIterableToArray(arr, i) || _nonIterableRest();
-}
-
-function _toConsumableArray(arr) {
-  return _arrayWithoutHoles(arr) || _iterableToArray(arr) || _unsupportedIterableToArray(arr) || _nonIterableSpread();
-}
-
-function _arrayWithoutHoles(arr) {
-  if (Array.isArray(arr)) return _arrayLikeToArray(arr);
-}
-
-function _arrayWithHoles(arr) {
-  if (Array.isArray(arr)) return arr;
-}
-
-function _iterableToArray(iter) {
-  if (typeof Symbol !== "undefined" && iter[Symbol.iterator] != null || iter["@@iterator"] != null) return Array.from(iter);
-}
-
-function _iterableToArrayLimit(arr, i) {
-  var _i = arr == null ? null : typeof Symbol !== "undefined" && arr[Symbol.iterator] || arr["@@iterator"];
-
-  if (_i == null) return;
-  var _arr = [];
-  var _n = true;
-  var _d = false;
-
-  var _s, _e;
-
-  try {
-    for (_i = _i.call(arr); !(_n = (_s = _i.next()).done); _n = true) {
-      _arr.push(_s.value);
-
-      if (i && _arr.length === i) break;
-    }
-  } catch (err) {
-    _d = true;
-    _e = err;
-  } finally {
-    try {
-      if (!_n && _i["return"] != null) _i["return"]();
-    } finally {
-      if (_d) throw _e;
-    }
-  }
-
-  return _arr;
-}
-
-function _unsupportedIterableToArray(o, minLen) {
-  if (!o) return;
-  if (typeof o === "string") return _arrayLikeToArray(o, minLen);
-  var n = Object.prototype.toString.call(o).slice(8, -1);
-  if (n === "Object" && o.constructor) n = o.constructor.name;
-  if (n === "Map" || n === "Set") return Array.from(o);
-  if (n === "Arguments" || /^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)) return _arrayLikeToArray(o, minLen);
-}
-
-function _arrayLikeToArray(arr, len) {
-  if (len == null || len > arr.length) len = arr.length;
-
-  for (var i = 0, arr2 = new Array(len); i < len; i++) arr2[i] = arr[i];
-
-  return arr2;
-}
-
-function _nonIterableSpread() {
-  throw new TypeError("Invalid attempt to spread non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.");
-}
-
-function _nonIterableRest() {
-  throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.");
-}
-
-var bgzipFastaAdapterConfigSchema = /*#__PURE__*/ConfigurationSchema('BgzipFastaAdapter', {
-  fastaLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/seq.fa.gz',
-      locationType: 'UriLocation'
-    }
-  },
-  faiLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/seq.fa.gz.fai',
-      locationType: 'UriLocation'
-    }
-  },
-  gziLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/seq.fa.gz.gzi',
-      locationType: 'UriLocation'
-    }
-  }
-}, {
-  explicitlyTyped: true
-});
-
-var chromSizesAdapterConfigSchema = /*#__PURE__*/ConfigurationSchema('ChromSizesAdapter', {
-  chromSizesLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/species.chrom.sizes',
-      locationType: 'UriLocation'
-    }
-  }
-}, {
-  explicitlyTyped: true
-});
-
-function Translation(props) {
-  var codonTable = props.codonTable,
-      seq = props.seq,
-      frame = props.frame,
-      bpPerPx = props.bpPerPx,
-      region = props.region,
-      height = props.height,
-      y = props.y,
-      _props$reverse = props.reverse,
-      reverse = _props$reverse === void 0 ? false : _props$reverse,
-      theme = props.theme;
-  var scale = bpPerPx; // the tilt variable normalizes the frame to where we are starting from,
-  // which increases consistency across blocks
-
-  var tilt = 3 - region.start % 3; // the effectiveFrame incorporates tilt and the frame to say what the
-  // effective frame that is plotted. The +3 is for when frame is -2 and this
-  // can otherwise result in effectiveFrame -1
-
-  var effectiveFrame = (frame + tilt + 3) % 3;
-  var seqSliced = seq.slice(effectiveFrame);
-  var translated = [];
-
-  for (var i = 0; i < seqSliced.length; i += 3) {
-    var codon = seqSliced.slice(i, i + 3);
-    var normalizedCodon = reverse ? revcom(codon) : codon;
-    var aminoAcid = codonTable[normalizedCodon] || '';
-    translated.push({
-      letter: aminoAcid,
-      codon: normalizedCodon.toUpperCase()
-    });
-  }
-
-  var w = 1 / scale * 3;
-  var drop = region.start === 0 ? 0 : w;
-  var render = 1 / bpPerPx >= 12;
-  var width = (region.end - region.start) / bpPerPx;
-  var map = ['#d8d8d8', '#adadad', '#8f8f8f'].reverse();
-  return React.createElement(React.Fragment, null, translated.map(function (element, index) {
-    var x = region.reversed ? width - (w * (index + 1) + effectiveFrame / scale - drop) : w * index + effectiveFrame / scale - drop;
-    var letter = element.letter,
-        codon = element.codon;
-    return React.createElement(React.Fragment, {
-      key: "".concat(index, "-").concat(letter)
-    }, React.createElement("rect", {
-      x: x,
-      y: y,
-      width: render ? w : w + 0.7
-      /* small fudge factor when zoomed out*/
-      ,
-      height: height,
-      stroke: render ? '#555' : 'none',
-      fill: defaultStarts.includes(codon) ? theme.palette.startCodon : defaultStops.includes(codon) ? theme.palette.stopCodon : map[Math.abs(frame)]
-    }), render ? React.createElement("text", {
-      x: x + w / 2,
-      y: y + height / 2,
-      dominantBaseline: "middle",
-      textAnchor: "middle"
-    }, letter) : null);
-  }));
-}
-
-function DNA(props) {
-  var bpPerPx = props.bpPerPx,
-      region = props.region,
-      feature = props.feature,
-      theme = props.theme,
-      height = props.height,
-      seq = props.seq,
-      y = props.y;
-  var render = 1 / bpPerPx >= 12;
-
-  var _bpSpanPx = bpSpanPx(feature.get('start'), feature.get('end'), region, bpPerPx),
-      _bpSpanPx2 = _slicedToArray(_bpSpanPx, 2),
-      leftPx = _bpSpanPx2[0],
-      rightPx = _bpSpanPx2[1];
-
-  var reverse = region.reversed;
-  var len = feature.get('end') - feature.get('start');
-  var w = Math.max((rightPx - leftPx) / len, 0.8);
-  return React.createElement(React.Fragment, null, seq.split('').map(function (letter, index) {
-    var color = theme.palette.bases[letter.toUpperCase()];
-    var x = reverse ? rightPx - (index + 1) * w : leftPx + index * w;
-    return React.createElement(React.Fragment, {
-      key: index
-    }, React.createElement("rect", {
-      x: x,
-      y: y,
-      width: w,
-      height: height,
-      fill: color ? color.main : '#aaa',
-      stroke: render ? '#555' : 'none'
-    }), render ? React.createElement("text", {
-      x: x + w / 2,
-      y: y + height / 2,
-      dominantBaseline: "middle",
-      textAnchor: "middle",
-      fill: color ? contrastingTextColor(color.main) : 'black'
-    }, letter) : null);
-  }));
-}
-
-var SequenceSVG = function SequenceSVG(_ref) {
-  var regions = _ref.regions,
-      configTheme = _ref.theme,
-      _ref$features = _ref.features,
-      features = _ref$features === void 0 ? new Map() : _ref$features,
-      showReverse = _ref.showReverse,
-      showForward = _ref.showForward,
-      showTranslation = _ref.showTranslation,
-      bpPerPx = _ref.bpPerPx;
-
-  var _regions = _slicedToArray(regions, 1),
-      region = _regions[0];
-
-  var theme = createJBrowseTheme(configTheme);
-  var codonTable = generateCodonTable(defaultCodonTable);
-  var height = 20;
-
-  var _ref2 = _toConsumableArray(features.values()),
-      feature = _ref2[0];
-
-  if (!feature) {
-    return null;
-  }
-
-  var seq = feature.get('seq');
-
-  if (!seq) {
-    return null;
-  } // incrementer for the y-position of the current sequence being rendered
-  // (applies to both translation rows and dna rows)
-
-
-  var currY = -20;
-  return React.createElement(React.Fragment, null, showTranslation && (region.reversed ? showReverse : showForward) ? [2, 1, 0].map(function (index) {
-    return React.createElement(Translation, {
-      key: "translation-".concat(index),
-      seq: seq,
-      y: currY += 20,
-      codonTable: codonTable,
-      frame: index,
-      bpPerPx: bpPerPx,
-      region: region,
-      theme: theme,
-      height: height,
-      reverse: region.reversed
-    });
-  }) : null, showForward ? React.createElement(DNA, {
-    height: height,
-    y: currY += 20,
-    feature: feature,
-    region: region,
-    seq: region.reversed ? complement(seq) : seq,
-    bpPerPx: bpPerPx,
-    theme: theme
-  }) : null, showReverse ? React.createElement(DNA, {
-    height: height,
-    y: currY += 20,
-    feature: feature,
-    region: region,
-    seq: region.reversed ? seq : complement(seq),
-    bpPerPx: bpPerPx,
-    theme: theme
-  }) : null, showTranslation && (region.reversed ? showForward : showReverse) ? [0, -1, -2].map(function (index) {
-    return React.createElement(Translation, {
-      key: "rev-translation-".concat(index),
-      seq: seq,
-      y: currY += 20,
-      codonTable: codonTable,
-      frame: index,
-      bpPerPx: bpPerPx,
-      region: region,
-      theme: theme,
-      height: height,
-      reverse: !region.reversed
-    });
-  }) : null);
-};
-
-var Wrapper = function Wrapper(_ref3) {
-  var exportSVG = _ref3.exportSVG,
-      width = _ref3.width,
-      totalHeight = _ref3.totalHeight,
-      children = _ref3.children;
-  return exportSVG ? React.createElement(React.Fragment, null, children) : React.createElement("svg", {
-    "data-testid": "sequence_track",
-    width: width,
-    height: totalHeight,
-    style: {
-      width: width,
-      height: totalHeight
-    }
-  }, children);
-};
-
-function Sequence(props) {
-  var regions = props.regions,
-      bpPerPx = props.bpPerPx;
-
-  var _regions2 = _slicedToArray(regions, 1),
-      region = _regions2[0];
-
-  var width = (region.end - region.start) / bpPerPx;
-  var totalHeight = 200;
-  return React.createElement(Wrapper, Object.assign({}, props, {
-    totalHeight: totalHeight,
-    width: width
-  }), React.createElement(SequenceSVG, Object.assign({}, props)));
-}
-
-var DivSequenceRendererReactComponent = /*#__PURE__*/observer(Sequence);
-
-var divSequenceRendererConfigSchema = /*#__PURE__*/ConfigurationSchema('DivSequenceRenderer', {
-  height: {
-    type: 'number',
-    description: 'height in pixels of each line of sequence',
-    defaultValue: 16
-  }
-}, {
-  explicitlyTyped: true
-});
-
-var indexedFastaAdapterConfigSchema = /*#__PURE__*/ConfigurationSchema('IndexedFastaAdapter', {
-  fastaLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/seq.fa',
-      locationType: 'UriLocation'
-    }
-  },
-  faiLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/seq.fa.fai',
-      locationType: 'UriLocation'
-    }
-  }
-}, {
-  explicitlyTyped: true
-});
-
-var configSchema = /*#__PURE__*/ConfigurationSchema('LinearReferenceSequenceDisplay', {
-  renderer: divSequenceRendererConfigSchema
-}, {
-  explicitIdentifier: 'displayId',
-  explicitlyTyped: true
-});
-
-function modelFactory(configSchema) {
-  return types.compose('LinearReferenceSequenceDisplay', BaseLinearDisplay, types.model({
-    type: types.literal('LinearReferenceSequenceDisplay'),
-    configuration: ConfigurationReference(configSchema),
-    showForward: types.optional(types["boolean"], true),
-    showReverse: types.optional(types["boolean"], true),
-    showTranslation: types.optional(types["boolean"], true),
-    height: 180
-  })).views(function (self) {
-    var superRenderProps = self.renderProps;
-    return {
-      renderProps: function renderProps() {
-        var showForward = self.showForward,
-            showReverse = self.showReverse,
-            showTranslation = self.showTranslation;
-        return _objectSpread2(_objectSpread2({}, superRenderProps()), {}, {
-          rpcDriverName: self.rpcDriverName,
-          config: self.configuration.renderer,
-          showForward: showForward,
-          showReverse: showReverse,
-          showTranslation: showTranslation
-        });
-      },
-      regionCannotBeRendered: function regionCannotBeRendered() {
-        var view = getContainingView(self);
-
-        if (view && view.bpPerPx >= 1) {
-          return 'Zoom in to see sequence';
-        }
-
-        return undefined;
-      },
-
-      get rendererTypeName() {
-        return self.configuration.renderer.type;
-      }
-
-    };
-  }).actions(function (self) {
-    return {
-      toggleShowForward: function toggleShowForward() {
-        self.showForward = !self.showForward;
-      },
-      toggleShowReverse: function toggleShowReverse() {
-        self.showReverse = !self.showReverse;
-      },
-      toggleShowTranslation: function toggleShowTranslation() {
-        self.showTranslation = !self.showTranslation;
-      }
-    };
-  }).views(function (self) {
-    return {
-      trackMenuItems: function trackMenuItems() {
-        return [{
-          label: 'Show forward',
-          type: 'checkbox',
-          checked: self.showForward,
-          onClick: function onClick() {
-            self.toggleShowForward();
-          }
-        }, {
-          label: 'Show reverse',
-          type: 'checkbox',
-          checked: self.showReverse,
-          onClick: function onClick() {
-            self.toggleShowReverse();
-          }
-        }, {
-          label: 'Show translation',
-          type: 'checkbox',
-          checked: self.showTranslation,
-          onClick: function onClick() {
-            self.toggleShowTranslation();
-          }
-        }];
-      }
-    };
-  });
-}
-
-var twoBitAdapterConfigSchema = /*#__PURE__*/ConfigurationSchema('TwoBitAdapter', {
-  twoBitLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/my.2bit',
-      locationType: 'UriLocation'
-    }
-  },
-  chromSizesLocation: {
-    type: 'fileLocation',
-    defaultValue: {
-      uri: '/path/to/default.chrom.sizes',
-      locationType: 'UriLocation'
-    },
-    description: 'An optional chrom.sizes file can be supplied to speed up loading since parsing the twobit file can take time'
-  }
-}, {
-  explicitlyTyped: true
-});
-
-var configSchemaF = (function (pluginManager) {
-  return ConfigurationSchema('GCContentAdapter', {
-    sequenceAdapter: pluginManager.pluggableConfigSchemaType('adapter')
-  }, {
-    explicitlyTyped: true
-  });
-});
-
-var GCContentAdapterF = (function (pluginManager) {
-  return {
-    configSchema: pluginManager.load(configSchemaF),
-    getAdapterClass: function getAdapterClass() {
-      return Promise.resolve().then(function () { return GCContentAdapter; }).then(function (r) {
-        return r["default"];
-      });
-    }
-  };
-});
-
-/*
-Note: this is primarily a copy of createBaseTrackConfig, except with a subset
-of the config slots, to avoid including fields that don't make sense for the
-ReferenceSequenceTrack
-*/
-
-function createReferenceSeqTrackConfig(pluginManager) {
-  return ConfigurationSchema('ReferenceSequenceTrack', {
-    adapter: pluginManager.pluggableConfigSchemaType('adapter'),
-    displays: types.array(pluginManager.pluggableConfigSchemaType('display')),
-    metadata: {
-      type: 'frozen',
-      description: 'anything to add about this track',
-      defaultValue: {}
-    }
-  }, {
-    preProcessSnapshot: function preProcessSnapshot(s) {
-      var snap = JSON.parse(JSON.stringify(s));
-      var displayTypes = new Set();
-      var _snap$displays = snap.displays,
-          displays = _snap$displays === void 0 ? [] : _snap$displays;
-
-      if (snap.trackId !== 'placeholderId') {
-        // Gets the displays on the track snapshot and the possible displays
-        // from the track type and adds any missing possible displays to the
-        // snapshot
-        displays.forEach(function (d) {
-          return d && displayTypes.add(d.type);
-        });
-        var trackType = pluginManager.getTrackType(snap.type);
-        trackType.displayTypes.forEach(function (displayType) {
-          if (!displayTypes.has(displayType.name)) {
-            displays.push({
-              displayId: "".concat(snap.trackId, "-").concat(displayType.name),
-              type: displayType.name
-            });
-          }
-        });
-      }
-
-      return _objectSpread2(_objectSpread2({}, snap), {}, {
-        displays: displays
-      });
-    },
-    explicitIdentifier: 'trackId',
-    explicitlyTyped: true,
-    actions: function actions(self) {
-      return {
-        addDisplayConf: function addDisplayConf(displayConf) {
-          var type = displayConf.type;
-
-          if (!type) {
-            throw new Error("unknown display type ".concat(type));
-          }
-
-          var display = self.displays.find(function (d) {
-            return d && d.displayId === displayConf.displayId;
-          });
-
-          if (display) {
-            return display;
-          }
-
-          var length = self.displays.push(displayConf);
-          return self.displays[length - 1];
-        }
-      };
-    }
-  });
-}
-
-/* adjust in both directions */
-
-var DivSequenceRenderer = /*#__PURE__*/function (_FeatureRendererType) {
-  _inherits(DivSequenceRenderer, _FeatureRendererType);
-
-  var _super = /*#__PURE__*/_createSuper(DivSequenceRenderer);
-
-  function DivSequenceRenderer() {
-    var _this;
-
-    _classCallCheck(this, DivSequenceRenderer);
-
-    _this = _super.apply(this, arguments);
-    _this.supportsSVG = true;
-    return _this;
-  }
-
-  _createClass(DivSequenceRenderer, [{
-    key: "getExpandedRegion",
-    value: function getExpandedRegion(region) {
-      return _objectSpread2(_objectSpread2({}, region), {}, {
-        start: Math.max(region.start - 3, 0),
-        end: region.end + 3
-      });
-    }
-  }]);
-
-  return DivSequenceRenderer;
-}(FeatureRendererType);
-
-var SequencePlugin = /*#__PURE__*/function (_Plugin) {
-  _inherits(SequencePlugin, _Plugin);
-
-  var _super2 = /*#__PURE__*/_createSuper(SequencePlugin);
-
-  function SequencePlugin() {
-    var _this2;
-
-    _classCallCheck(this, SequencePlugin);
-
-    _this2 = _super2.apply(this, arguments);
-    _this2.name = 'SequencePlugin';
-    return _this2;
-  }
-
-  _createClass(SequencePlugin, [{
-    key: "install",
-    value: function install(pluginManager) {
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'TwoBitAdapter',
-          configSchema: twoBitAdapterConfigSchema,
-          adapterMetadata: {
-            category: null,
-            hiddenFromGUI: true,
-            displayName: null,
-            description: null
-          },
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return TwoBitAdapter$1; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addToExtensionPoint('Core-guessAdapterForLocation', function (adapterGuesser) {
-        return function (file, index, adapterHint) {
-          var regexGuess = /\.2bit$/i;
-          var adapterName = 'TwoBitAdapter';
-          var fileName = getFileName(file);
-          var obj = {
-            type: adapterName,
-            twoBitLocation: file
-          };
-
-          if (regexGuess.test(fileName) && !adapterHint) {
-            return obj;
-          } else if (adapterHint === adapterName) {
-            return obj;
-          }
-
-          return adapterGuesser(file, index, adapterHint);
-        };
-      });
-      pluginManager.addToExtensionPoint('Core-guessTrackTypeForLocation', function (trackTypeGuesser) {
-        return function (adapterName) {
-          if (adapterName === 'TwoBitAdapter') {
-            return 'ReferenceSequenceTrack';
-          }
-
-          return trackTypeGuesser(adapterName);
-        };
-      });
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'ChromSizesAdapter',
-          configSchema: chromSizesAdapterConfigSchema,
-          adapterMetadata: {
-            category: null,
-            hiddenFromGUI: true,
-            displayName: null,
-            description: null
-          },
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return ChromSizesAdapter; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'IndexedFastaAdapter',
-          configSchema: indexedFastaAdapterConfigSchema,
-          adapterMetadata: {
-            category: null,
-            hiddenFromGUI: true,
-            displayName: null,
-            description: null
-          },
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return IndexedFastaAdapter; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addToExtensionPoint('Core-guessAdapterForLocation', function (adapterGuesser) {
-        return function (file, index, adapterHint) {
-          var regexGuess = /\.(fa|fasta|fas|fna|mfa)$/i;
-          var adapterName = 'IndexedFastaAdapter';
-          var fileName = getFileName(file);
-          var obj = {
-            type: adapterName,
-            fastaLocation: file,
-            faiLocation: index || makeIndex(file, '.fai')
-          };
-
-          if (regexGuess.test(fileName) && !adapterHint) {
-            return obj;
-          } else if (adapterHint === adapterName) {
-            return obj;
-          }
-
-          return adapterGuesser(file, index, adapterHint);
-        };
-      });
-      pluginManager.addToExtensionPoint('Core-guessTrackTypeForLocation', function (trackTypeGuesser) {
-        return function (adapterName) {
-          if (adapterName === 'IndexedFastaAdapter') {
-            return 'ReferenceSequenceTrack';
-          }
-
-          return trackTypeGuesser(adapterName);
-        };
-      });
-      pluginManager.addAdapterType(function () {
-        return new AdapterType({
-          name: 'BgzipFastaAdapter',
-          configSchema: bgzipFastaAdapterConfigSchema,
-          adapterMetadata: {
-            category: null,
-            hiddenFromGUI: true,
-            displayName: null,
-            description: null
-          },
-          getAdapterClass: function getAdapterClass() {
-            return Promise.resolve().then(function () { return BgzipFastaAdapter; }).then(function (r) {
-              return r["default"];
-            });
-          }
-        });
-      });
-      pluginManager.addToExtensionPoint('Core-guessAdapterForLocation', function (adapterGuesser) {
-        return function (file, index, adapterHint) {
-          var regexGuess = /\.(fa|fasta|fas|fna|mfa)\.b?gz$/i;
-          var adapterName = 'BgzipFastaAdapter';
-          var fileName = getFileName(file);
-          var obj = {
-            type: adapterName,
-            faiLocation: makeIndex(file, '.fai'),
-            gziLocation: makeIndex(file, '.gzi')
-          };
-
-          if (regexGuess.test(fileName) && !adapterHint) {
-            return obj;
-          } else if (adapterHint === adapterName) {
-            return obj;
-          }
-
-          return adapterGuesser(file, index, adapterHint);
-        };
-      });
-      pluginManager.addToExtensionPoint('Core-guessTrackTypeForLocation', function (trackTypeGuesser) {
-        return function (adapterName) {
-          if (adapterName === 'BgzipFastaAdapter') {
-            return 'ReferenceSequenceTrack';
-          }
-
-          return trackTypeGuesser(adapterName);
-        };
-      });
-      pluginManager.addAdapterType(function () {
-        return new AdapterType(_objectSpread2({
-          name: 'GCContentAdapter',
-          adapterMetadata: {
-            category: null,
-            hiddenFromGUI: true,
-            displayName: null,
-            description: null
-          }
-        }, pluginManager.load(GCContentAdapterF)));
-      });
-      pluginManager.addTrackType(function () {
-        var configSchema = createReferenceSeqTrackConfig(pluginManager);
-        return new TrackType({
-          name: 'ReferenceSequenceTrack',
-          configSchema: configSchema,
-          stateModel: createBaseTrackModel(pluginManager, 'ReferenceSequenceTrack', configSchema)
-        });
-      });
-      pluginManager.addDisplayType(function () {
-        var stateModel = modelFactory(configSchema);
-        return {
-          name: 'LinearReferenceSequenceDisplay',
-          configSchema: configSchema,
-          stateModel: stateModel,
-          trackType: 'ReferenceSequenceTrack',
-          viewType: 'LinearGenomeView',
-          ReactComponent: BaseLinearDisplayComponent
-        };
-      });
-      pluginManager.addRendererType(function () {
-        return new DivSequenceRenderer({
-          name: 'DivSequenceRenderer',
-          ReactComponent: DivSequenceRendererReactComponent,
-          configSchema: divSequenceRendererConfigSchema,
-          pluginManager: pluginManager
-        });
-      });
-    }
-  }]);
-
-  return SequencePlugin;
-}(Plugin);
-
-function createCommonjsModule(fn, module) {
-	return module = { exports: {} }, fn(module, module.exports), module.exports;
-}
-
-var runtime_1 = /*#__PURE__*/createCommonjsModule(function (module) {
-  /**
-   * Copyright (c) 2014-present, Facebook, Inc.
-   *
-   * This source code is licensed under the MIT license found in the
-   * LICENSE file in the root directory of this source tree.
-   */
-  var runtime = function (exports) {
-
-    var Op = Object.prototype;
-    var hasOwn = Op.hasOwnProperty;
-    var undefined$1; // More compressible than void 0.
-
-    var $Symbol = typeof Symbol === "function" ? Symbol : {};
-    var iteratorSymbol = $Symbol.iterator || "@@iterator";
-    var asyncIteratorSymbol = $Symbol.asyncIterator || "@@asyncIterator";
-    var toStringTagSymbol = $Symbol.toStringTag || "@@toStringTag";
-
-    function define(obj, key, value) {
-      Object.defineProperty(obj, key, {
-        value: value,
-        enumerable: true,
-        configurable: true,
-        writable: true
-      });
-      return obj[key];
-    }
-
-    try {
-      // IE 8 has a broken Object.defineProperty that only works on DOM objects.
-      define({}, "");
-    } catch (err) {
-      define = function define(obj, key, value) {
-        return obj[key] = value;
-      };
-    }
-
-    function wrap(innerFn, outerFn, self, tryLocsList) {
-      // If outerFn provided and outerFn.prototype is a Generator, then outerFn.prototype instanceof Generator.
-      var protoGenerator = outerFn && outerFn.prototype instanceof Generator ? outerFn : Generator;
-      var generator = Object.create(protoGenerator.prototype);
-      var context = new Context(tryLocsList || []); // The ._invoke method unifies the implementations of the .next,
-      // .throw, and .return methods.
-
-      generator._invoke = makeInvokeMethod(innerFn, self, context);
-      return generator;
-    }
-
-    exports.wrap = wrap; // Try/catch helper to minimize deoptimizations. Returns a completion
-    // record like context.tryEntries[i].completion. This interface could
-    // have been (and was previously) designed to take a closure to be
-    // invoked without arguments, but in all the cases we care about we
-    // already have an existing method we want to call, so there's no need
-    // to create a new function object. We can even get away with assuming
-    // the method takes exactly one argument, since that happens to be true
-    // in every case, so we don't have to touch the arguments object. The
-    // only additional allocation required is the completion record, which
-    // has a stable shape and so hopefully should be cheap to allocate.
-
-    function tryCatch(fn, obj, arg) {
-      try {
-        return {
-          type: "normal",
-          arg: fn.call(obj, arg)
-        };
-      } catch (err) {
-        return {
-          type: "throw",
-          arg: err
-        };
-      }
-    }
-
-    var GenStateSuspendedStart = "suspendedStart";
-    var GenStateSuspendedYield = "suspendedYield";
-    var GenStateExecuting = "executing";
-    var GenStateCompleted = "completed"; // Returning this object from the innerFn has the same effect as
-    // breaking out of the dispatch switch statement.
-
-    var ContinueSentinel = {}; // Dummy constructor functions that we use as the .constructor and
-    // .constructor.prototype properties for functions that return Generator
-    // objects. For full spec compliance, you may wish to configure your
-    // minifier not to mangle the names of these two functions.
-
-    function Generator() {}
-
-    function GeneratorFunction() {}
-
-    function GeneratorFunctionPrototype() {} // This is a polyfill for %IteratorPrototype% for environments that
-    // don't natively support it.
-
-
-    var IteratorPrototype = {};
-    define(IteratorPrototype, iteratorSymbol, function () {
-      return this;
-    });
-    var getProto = Object.getPrototypeOf;
-    var NativeIteratorPrototype = getProto && getProto(getProto(values([])));
-
-    if (NativeIteratorPrototype && NativeIteratorPrototype !== Op && hasOwn.call(NativeIteratorPrototype, iteratorSymbol)) {
-      // This environment has a native %IteratorPrototype%; use it instead
-      // of the polyfill.
-      IteratorPrototype = NativeIteratorPrototype;
-    }
-
-    var Gp = GeneratorFunctionPrototype.prototype = Generator.prototype = Object.create(IteratorPrototype);
-    GeneratorFunction.prototype = GeneratorFunctionPrototype;
-    define(Gp, "constructor", GeneratorFunctionPrototype);
-    define(GeneratorFunctionPrototype, "constructor", GeneratorFunction);
-    GeneratorFunction.displayName = define(GeneratorFunctionPrototype, toStringTagSymbol, "GeneratorFunction"); // Helper for defining the .next, .throw, and .return methods of the
-    // Iterator interface in terms of a single ._invoke method.
-
-    function defineIteratorMethods(prototype) {
-      ["next", "throw", "return"].forEach(function (method) {
-        define(prototype, method, function (arg) {
-          return this._invoke(method, arg);
-        });
-      });
-    }
-
-    exports.isGeneratorFunction = function (genFun) {
-      var ctor = typeof genFun === "function" && genFun.constructor;
-      return ctor ? ctor === GeneratorFunction || // For the native GeneratorFunction constructor, the best we can
-      // do is to check its .name property.
-      (ctor.displayName || ctor.name) === "GeneratorFunction" : false;
-    };
-
-    exports.mark = function (genFun) {
-      if (Object.setPrototypeOf) {
-        Object.setPrototypeOf(genFun, GeneratorFunctionPrototype);
-      } else {
-        genFun.__proto__ = GeneratorFunctionPrototype;
-        define(genFun, toStringTagSymbol, "GeneratorFunction");
-      }
-
-      genFun.prototype = Object.create(Gp);
-      return genFun;
-    }; // Within the body of any async function, `await x` is transformed to
-    // `yield regeneratorRuntime.awrap(x)`, so that the runtime can test
-    // `hasOwn.call(value, "__await")` to determine if the yielded value is
-    // meant to be awaited.
-
-
-    exports.awrap = function (arg) {
-      return {
-        __await: arg
-      };
-    };
-
-    function AsyncIterator(generator, PromiseImpl) {
-      function invoke(method, arg, resolve, reject) {
-        var record = tryCatch(generator[method], generator, arg);
-
-        if (record.type === "throw") {
-          reject(record.arg);
-        } else {
-          var result = record.arg;
-          var value = result.value;
-
-          if (value && typeof value === "object" && hasOwn.call(value, "__await")) {
-            return PromiseImpl.resolve(value.__await).then(function (value) {
-              invoke("next", value, resolve, reject);
-            }, function (err) {
-              invoke("throw", err, resolve, reject);
-            });
-          }
-
-          return PromiseImpl.resolve(value).then(function (unwrapped) {
-            // When a yielded Promise is resolved, its final value becomes
-            // the .value of the Promise<{value,done}> result for the
-            // current iteration.
-            result.value = unwrapped;
-            resolve(result);
-          }, function (error) {
-            // If a rejected Promise was yielded, throw the rejection back
-            // into the async generator function so it can be handled there.
-            return invoke("throw", error, resolve, reject);
-          });
-        }
-      }
-
-      var previousPromise;
-
-      function enqueue(method, arg) {
-        function callInvokeWithMethodAndArg() {
-          return new PromiseImpl(function (resolve, reject) {
-            invoke(method, arg, resolve, reject);
-          });
-        }
-
-        return previousPromise = // If enqueue has been called before, then we want to wait until
-        // all previous Promises have been resolved before calling invoke,
-        // so that results are always delivered in the correct order. If
-        // enqueue has not been called before, then it is important to
-        // call invoke immediately, without waiting on a callback to fire,
-        // so that the async generator function has the opportunity to do
-        // any necessary setup in a predictable way. This predictability
-        // is why the Promise constructor synchronously invokes its
-        // executor callback, and why async functions synchronously
-        // execute code before the first await. Since we implement simple
-        // async functions in terms of async generators, it is especially
-        // important to get this right, even though it requires care.
-        previousPromise ? previousPromise.then(callInvokeWithMethodAndArg, // Avoid propagating failures to Promises returned by later
-        // invocations of the iterator.
-        callInvokeWithMethodAndArg) : callInvokeWithMethodAndArg();
-      } // Define the unified helper method that is used to implement .next,
-      // .throw, and .return (see defineIteratorMethods).
-
-
-      this._invoke = enqueue;
-    }
-
-    defineIteratorMethods(AsyncIterator.prototype);
-    define(AsyncIterator.prototype, asyncIteratorSymbol, function () {
-      return this;
-    });
-    exports.AsyncIterator = AsyncIterator; // Note that simple async functions are implemented on top of
-    // AsyncIterator objects; they just return a Promise for the value of
-    // the final result produced by the iterator.
-
-    exports.async = function (innerFn, outerFn, self, tryLocsList, PromiseImpl) {
-      if (PromiseImpl === void 0) PromiseImpl = Promise;
-      var iter = new AsyncIterator(wrap(innerFn, outerFn, self, tryLocsList), PromiseImpl);
-      return exports.isGeneratorFunction(outerFn) ? iter // If outerFn is a generator, return the full iterator.
-      : iter.next().then(function (result) {
-        return result.done ? result.value : iter.next();
-      });
-    };
-
-    function makeInvokeMethod(innerFn, self, context) {
-      var state = GenStateSuspendedStart;
-      return function invoke(method, arg) {
-        if (state === GenStateExecuting) {
-          throw new Error("Generator is already running");
-        }
-
-        if (state === GenStateCompleted) {
-          if (method === "throw") {
-            throw arg;
-          } // Be forgiving, per 25.3.3.3.3 of the spec:
-          // https://people.mozilla.org/~jorendorff/es6-draft.html#sec-generatorresume
-
-
-          return doneResult();
-        }
-
-        context.method = method;
-        context.arg = arg;
-
-        while (true) {
-          var delegate = context.delegate;
-
-          if (delegate) {
-            var delegateResult = maybeInvokeDelegate(delegate, context);
-
-            if (delegateResult) {
-              if (delegateResult === ContinueSentinel) continue;
-              return delegateResult;
-            }
-          }
-
-          if (context.method === "next") {
-            // Setting context._sent for legacy support of Babel's
-            // function.sent implementation.
-            context.sent = context._sent = context.arg;
-          } else if (context.method === "throw") {
-            if (state === GenStateSuspendedStart) {
-              state = GenStateCompleted;
-              throw context.arg;
-            }
-
-            context.dispatchException(context.arg);
-          } else if (context.method === "return") {
-            context.abrupt("return", context.arg);
-          }
-
-          state = GenStateExecuting;
-          var record = tryCatch(innerFn, self, context);
-
-          if (record.type === "normal") {
-            // If an exception is thrown from innerFn, we leave state ===
-            // GenStateExecuting and loop back for another invocation.
-            state = context.done ? GenStateCompleted : GenStateSuspendedYield;
-
-            if (record.arg === ContinueSentinel) {
-              continue;
-            }
-
-            return {
-              value: record.arg,
-              done: context.done
-            };
-          } else if (record.type === "throw") {
-            state = GenStateCompleted; // Dispatch the exception by looping back around to the
-            // context.dispatchException(context.arg) call above.
-
-            context.method = "throw";
-            context.arg = record.arg;
-          }
-        }
-      };
-    } // Call delegate.iterator[context.method](context.arg) and handle the
-    // result, either by returning a { value, done } result from the
-    // delegate iterator, or by modifying context.method and context.arg,
-    // setting context.delegate to null, and returning the ContinueSentinel.
-
-
-    function maybeInvokeDelegate(delegate, context) {
-      var method = delegate.iterator[context.method];
-
-      if (method === undefined$1) {
-        // A .throw or .return when the delegate iterator has no .throw
-        // method always terminates the yield* loop.
-        context.delegate = null;
-
-        if (context.method === "throw") {
-          // Note: ["return"] must be used for ES3 parsing compatibility.
-          if (delegate.iterator["return"]) {
-            // If the delegate iterator has a return method, give it a
-            // chance to clean up.
-            context.method = "return";
-            context.arg = undefined$1;
-            maybeInvokeDelegate(delegate, context);
-
-            if (context.method === "throw") {
-              // If maybeInvokeDelegate(context) changed context.method from
-              // "return" to "throw", let that override the TypeError below.
-              return ContinueSentinel;
-            }
-          }
-
-          context.method = "throw";
-          context.arg = new TypeError("The iterator does not provide a 'throw' method");
-        }
-
-        return ContinueSentinel;
-      }
-
-      var record = tryCatch(method, delegate.iterator, context.arg);
-
-      if (record.type === "throw") {
-        context.method = "throw";
-        context.arg = record.arg;
-        context.delegate = null;
-        return ContinueSentinel;
-      }
-
-      var info = record.arg;
-
-      if (!info) {
-        context.method = "throw";
-        context.arg = new TypeError("iterator result is not an object");
-        context.delegate = null;
-        return ContinueSentinel;
-      }
-
-      if (info.done) {
-        // Assign the result of the finished delegate to the temporary
-        // variable specified by delegate.resultName (see delegateYield).
-        context[delegate.resultName] = info.value; // Resume execution at the desired location (see delegateYield).
-
-        context.next = delegate.nextLoc; // If context.method was "throw" but the delegate handled the
-        // exception, let the outer generator proceed normally. If
-        // context.method was "next", forget context.arg since it has been
-        // "consumed" by the delegate iterator. If context.method was
-        // "return", allow the original .return call to continue in the
-        // outer generator.
-
-        if (context.method !== "return") {
-          context.method = "next";
-          context.arg = undefined$1;
-        }
-      } else {
-        // Re-yield the result returned by the delegate method.
-        return info;
-      } // The delegate iterator is finished, so forget it and continue with
-      // the outer generator.
-
-
-      context.delegate = null;
-      return ContinueSentinel;
-    } // Define Generator.prototype.{next,throw,return} in terms of the
-    // unified ._invoke helper method.
-
-
-    defineIteratorMethods(Gp);
-    define(Gp, toStringTagSymbol, "Generator"); // A Generator should always return itself as the iterator object when the
-    // @@iterator function is called on it. Some browsers' implementations of the
-    // iterator prototype chain incorrectly implement this, causing the Generator
-    // object to not be returned from this call. This ensures that doesn't happen.
-    // See https://github.com/facebook/regenerator/issues/274 for more details.
-
-    define(Gp, iteratorSymbol, function () {
-      return this;
-    });
-    define(Gp, "toString", function () {
-      return "[object Generator]";
-    });
-
-    function pushTryEntry(locs) {
-      var entry = {
-        tryLoc: locs[0]
-      };
-
-      if (1 in locs) {
-        entry.catchLoc = locs[1];
-      }
-
-      if (2 in locs) {
-        entry.finallyLoc = locs[2];
-        entry.afterLoc = locs[3];
-      }
-
-      this.tryEntries.push(entry);
-    }
-
-    function resetTryEntry(entry) {
-      var record = entry.completion || {};
-      record.type = "normal";
-      delete record.arg;
-      entry.completion = record;
-    }
-
-    function Context(tryLocsList) {
-      // The root entry object (effectively a try statement without a catch
-      // or a finally block) gives us a place to store values thrown from
-      // locations where there is no enclosing try statement.
-      this.tryEntries = [{
-        tryLoc: "root"
-      }];
-      tryLocsList.forEach(pushTryEntry, this);
-      this.reset(true);
-    }
-
-    exports.keys = function (object) {
-      var keys = [];
-
-      for (var key in object) {
-        keys.push(key);
-      }
-
-      keys.reverse(); // Rather than returning an object with a next method, we keep
-      // things simple and return the next function itself.
-
-      return function next() {
-        while (keys.length) {
-          var key = keys.pop();
-
-          if (key in object) {
-            next.value = key;
-            next.done = false;
-            return next;
-          }
-        } // To avoid creating an additional object, we just hang the .value
-        // and .done properties off the next function object itself. This
-        // also ensures that the minifier will not anonymize the function.
-
-
-        next.done = true;
-        return next;
-      };
-    };
-
-    function values(iterable) {
-      if (iterable) {
-        var iteratorMethod = iterable[iteratorSymbol];
-
-        if (iteratorMethod) {
-          return iteratorMethod.call(iterable);
-        }
-
-        if (typeof iterable.next === "function") {
-          return iterable;
-        }
-
-        if (!isNaN(iterable.length)) {
-          var i = -1,
-              next = function next() {
-            while (++i < iterable.length) {
-              if (hasOwn.call(iterable, i)) {
-                next.value = iterable[i];
-                next.done = false;
-                return next;
-              }
-            }
-
-            next.value = undefined$1;
-            next.done = true;
-            return next;
-          };
-
-          return next.next = next;
-        }
-      } // Return an iterator with no values.
-
-
-      return {
-        next: doneResult
-      };
-    }
-
-    exports.values = values;
-
-    function doneResult() {
-      return {
-        value: undefined$1,
-        done: true
-      };
-    }
-
-    Context.prototype = {
-      constructor: Context,
-      reset: function reset(skipTempReset) {
-        this.prev = 0;
-        this.next = 0; // Resetting context._sent for legacy support of Babel's
-        // function.sent implementation.
-
-        this.sent = this._sent = undefined$1;
-        this.done = false;
-        this.delegate = null;
-        this.method = "next";
-        this.arg = undefined$1;
-        this.tryEntries.forEach(resetTryEntry);
-
-        if (!skipTempReset) {
-          for (var name in this) {
-            // Not sure about the optimal order of these conditions:
-            if (name.charAt(0) === "t" && hasOwn.call(this, name) && !isNaN(+name.slice(1))) {
-              this[name] = undefined$1;
-            }
-          }
-        }
-      },
-      stop: function stop() {
-        this.done = true;
-        var rootEntry = this.tryEntries[0];
-        var rootRecord = rootEntry.completion;
-
-        if (rootRecord.type === "throw") {
-          throw rootRecord.arg;
-        }
-
-        return this.rval;
-      },
-      dispatchException: function dispatchException(exception) {
-        if (this.done) {
-          throw exception;
-        }
-
-        var context = this;
-
-        function handle(loc, caught) {
-          record.type = "throw";
-          record.arg = exception;
-          context.next = loc;
-
-          if (caught) {
-            // If the dispatched exception was caught by a catch block,
-            // then let that catch block handle the exception normally.
-            context.method = "next";
-            context.arg = undefined$1;
-          }
-
-          return !!caught;
-        }
-
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-          var record = entry.completion;
-
-          if (entry.tryLoc === "root") {
-            // Exception thrown outside of any try block that could handle
-            // it, so set the completion value of the entire function to
-            // throw the exception.
-            return handle("end");
-          }
-
-          if (entry.tryLoc <= this.prev) {
-            var hasCatch = hasOwn.call(entry, "catchLoc");
-            var hasFinally = hasOwn.call(entry, "finallyLoc");
-
-            if (hasCatch && hasFinally) {
-              if (this.prev < entry.catchLoc) {
-                return handle(entry.catchLoc, true);
-              } else if (this.prev < entry.finallyLoc) {
-                return handle(entry.finallyLoc);
-              }
-            } else if (hasCatch) {
-              if (this.prev < entry.catchLoc) {
-                return handle(entry.catchLoc, true);
-              }
-            } else if (hasFinally) {
-              if (this.prev < entry.finallyLoc) {
-                return handle(entry.finallyLoc);
-              }
-            } else {
-              throw new Error("try statement without catch or finally");
-            }
-          }
-        }
-      },
-      abrupt: function abrupt(type, arg) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.tryLoc <= this.prev && hasOwn.call(entry, "finallyLoc") && this.prev < entry.finallyLoc) {
-            var finallyEntry = entry;
-            break;
-          }
-        }
-
-        if (finallyEntry && (type === "break" || type === "continue") && finallyEntry.tryLoc <= arg && arg <= finallyEntry.finallyLoc) {
-          // Ignore the finally entry if control is not jumping to a
-          // location outside the try/catch block.
-          finallyEntry = null;
-        }
-
-        var record = finallyEntry ? finallyEntry.completion : {};
-        record.type = type;
-        record.arg = arg;
-
-        if (finallyEntry) {
-          this.method = "next";
-          this.next = finallyEntry.finallyLoc;
-          return ContinueSentinel;
-        }
-
-        return this.complete(record);
-      },
-      complete: function complete(record, afterLoc) {
-        if (record.type === "throw") {
-          throw record.arg;
-        }
-
-        if (record.type === "break" || record.type === "continue") {
-          this.next = record.arg;
-        } else if (record.type === "return") {
-          this.rval = this.arg = record.arg;
-          this.method = "return";
-          this.next = "end";
-        } else if (record.type === "normal" && afterLoc) {
-          this.next = afterLoc;
-        }
-
-        return ContinueSentinel;
-      },
-      finish: function finish(finallyLoc) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.finallyLoc === finallyLoc) {
-            this.complete(entry.completion, entry.afterLoc);
-            resetTryEntry(entry);
-            return ContinueSentinel;
-          }
-        }
-      },
-      "catch": function _catch(tryLoc) {
-        for (var i = this.tryEntries.length - 1; i >= 0; --i) {
-          var entry = this.tryEntries[i];
-
-          if (entry.tryLoc === tryLoc) {
-            var record = entry.completion;
-
-            if (record.type === "throw") {
-              var thrown = record.arg;
-              resetTryEntry(entry);
-            }
-
-            return thrown;
-          }
-        } // The context.catch method must only be called with a location
-        // argument that corresponds to a known catch block.
-
-
-        throw new Error("illegal catch attempt");
-      },
-      delegateYield: function delegateYield(iterable, resultName, nextLoc) {
-        this.delegate = {
-          iterator: values(iterable),
-          resultName: resultName,
-          nextLoc: nextLoc
-        };
-
-        if (this.method === "next") {
-          // Deliberately forget the last sent value so that we don't
-          // accidentally pass it on to the delegate.
-          this.arg = undefined$1;
-        }
-
-        return ContinueSentinel;
-      }
-    }; // Regardless of whether this script is executing as a CommonJS module
-    // or not, return the runtime object so that we can declare the variable
-    // regeneratorRuntime in the outer scope, which allows this module to be
-    // injected easily by `bin/regenerator --include-runtime script.js`.
-
-    return exports;
-  }( // If this script is executing as a CommonJS module, use module.exports
-  // as the regeneratorRuntime namespace. Otherwise create a new empty
-  // object. Either way, the resulting object will be used to initialize
-  // the regeneratorRuntime variable at the top of this file.
-   module.exports );
-
-  try {
-    regeneratorRuntime = runtime;
-  } catch (accidentalStrictMode) {
-    // This module should not be running in strict mode, so the above
-    // assignment should always work unless something is misconfigured. Just
-    // in case runtime.js accidentally runs in strict mode, in modern engines
-    // we can explicitly access globalThis. In older engines we can escape
-    // strict mode using a global Function call. This could conceivably fail
-    // if a Content Security Policy forbids using Function, but in that case
-    // the proper solution is to fix the accidental strict mode problem. If
-    // you've misconfigured your bundler to force strict mode and applied a
-    // CSP to forbid Function, and you're not willing to fix either of those
-    // problems, please detail your unique predicament in a GitHub issue.
-    if (typeof globalThis === "object") {
-      globalThis.regeneratorRuntime = runtime;
-    } else {
-      Function("r", "regeneratorRuntime = r")(runtime);
-    }
-  }
-});
-
-var default_1 = /*#__PURE__*/function (_BaseFeatureDataAdapt) {
-  _inherits(default_1, _BaseFeatureDataAdapt);
-
-  var _super = /*#__PURE__*/_createSuper(default_1);
-
-  function default_1() {
-    var _this;
-
-    _classCallCheck(this, default_1);
-
-    _this = _super.apply(this, arguments);
-    _this.windowSize = 1000;
-    _this.windowDelta = 1000;
-    _this.gcMode = 'content';
-    return _this;
-  }
-
-  _createClass(default_1, [{
-    key: "configure",
-    value: function () {
-      var _configure = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee() {
-        var _this$getSubAdapter;
-
-        var sequenceAdapter, dataAdapter;
-        return runtime_1.wrap(function _callee$(_context) {
-          while (1) {
-            switch (_context.prev = _context.next) {
-              case 0:
-                // instantiate the sequence adapter
-                sequenceAdapter = readConfObject(this.config, 'sequenceAdapter');
-                _context.next = 3;
-                return (_this$getSubAdapter = this.getSubAdapter) === null || _this$getSubAdapter === void 0 ? void 0 : _this$getSubAdapter.call(this, sequenceAdapter);
-
-              case 3:
-                dataAdapter = _context.sent;
-
-                if (dataAdapter) {
-                  _context.next = 6;
-                  break;
-                }
-
-                throw new Error('Error getting subadapter');
-
-              case 6:
-                return _context.abrupt("return", dataAdapter.dataAdapter);
-
-              case 7:
-              case "end":
-                return _context.stop();
-            }
-          }
-        }, _callee, this);
-      }));
-
-      function configure() {
-        return _configure.apply(this, arguments);
-      }
-
-      return configure;
-    }()
-  }, {
-    key: "getRefNames",
-    value: function () {
-      var _getRefNames = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2() {
-        var sequenceAdapter;
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                _context2.next = 2;
-                return this.configure();
-
-              case 2:
-                sequenceAdapter = _context2.sent;
-                return _context2.abrupt("return", sequenceAdapter.getRefNames());
-
-              case 4:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function getRefNames() {
-        return _getRefNames.apply(this, arguments);
-      }
-
-      return getRefNames;
-    }()
-    /**
-     * Fetch features for a certain region
-     * @param param -
-     * @returns Observable of Feature objects in the region
-     */
-
-  }, {
-    key: "getFeatures",
-    value: function getFeatures(query, opts) {
-      var _this2 = this;
-
-      this.windowSize = 1000;
-      this.windowDelta = 1000;
-      this.gcMode = 'content';
-      return ObservableCreate( /*#__PURE__*/function () {
-        var _ref = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee3(observer) {
-          var _feats$;
-
-          var sequenceAdapter, hw, f, queryStart, queryEnd, ret, feats, residues, i, r, nc, ng, len, j, pos, score;
-          return runtime_1.wrap(function _callee3$(_context3) {
-            while (1) {
-              switch (_context3.prev = _context3.next) {
-                case 0:
-                  _context3.next = 2;
-                  return _this2.configure();
-
-                case 2:
-                  sequenceAdapter = _context3.sent;
-                  hw = _this2.windowSize === 1 ? 1 : _this2.windowSize / 2; // Half the window size
-
-                  f = _this2.windowSize === 1;
-                  queryStart = query.start, queryEnd = query.end;
-                  queryStart = Math.max(0, queryStart - hw);
-                  queryEnd += hw;
-
-                  if (!(queryEnd < 0 || queryStart > queryEnd)) {
-                    _context3.next = 11;
-                    break;
-                  }
-
-                  observer.complete();
-                  return _context3.abrupt("return");
-
-                case 11:
-                  ret = sequenceAdapter.getFeatures(_objectSpread2(_objectSpread2({}, query), {}, {
-                    start: queryStart,
-                    end: queryEnd
-                  }));
-                  _context3.next = 14;
-                  return ret.pipe(toArray()).toPromise();
-
-                case 14:
-                  feats = _context3.sent;
-                  residues = ((_feats$ = feats[0]) === null || _feats$ === void 0 ? void 0 : _feats$.get('seq')) || '';
-
-                  for (i = hw; i < residues.length - hw; i += _this2.windowDelta) {
-                    r = f ? residues[i] : residues.slice(i - hw, i + hw);
-                    nc = 0;
-                    ng = 0;
-                    len = 0;
-
-                    for (j = 0; j < r.length; j++) {
-                      if (r[j] === 'c' || r[j] === 'C') {
-                        nc++;
-                      } else if (r[j] === 'g' || r[j] === 'G') {
-                        ng++;
-                      }
-
-                      if (r[j] !== 'N') {
-                        len++;
-                      }
-                    }
-
-                    pos = queryStart;
-                    score = void 0;
-
-                    if (_this2.gcMode === 'content') {
-                      score = (ng + nc) / (len || 1);
-                    } else if (_this2.gcMode === 'skew') {
-                      score = (ng - nc) / (ng + nc || 1);
-                    }
-
-                    observer.next(new SimpleFeature({
-                      uniqueId: "".concat(_this2.id, "_").concat(pos + i),
-                      start: pos + i,
-                      end: pos + i + _this2.windowDelta,
-                      score: score
-                    }));
-                  }
-
-                  observer.complete();
-
-                case 18:
-                case "end":
-                  return _context3.stop();
-              }
-            }
-          }, _callee3);
-        }));
-
-        return function (_x) {
-          return _ref.apply(this, arguments);
-        };
-      }());
-    }
-    /**
-     * called to provide a hint that data tied to a certain region
-     * will not be needed for the forseeable future and can be purged
-     * from caches, etc
-     */
-
-  }, {
-    key: "freeResources",
-    value: function
-      /* { region } */
-    freeResources() {}
-  }]);
-
-  return default_1;
-}(BaseFeatureDataAdapter);
-default_1.capabilities = ['hasLocalStats'];
-
-var GCContentAdapter = {
-  __proto__: null,
-  'default': default_1
-};
-
-var TwoBitAdapter = /*#__PURE__*/function (_BaseSequenceAdapter) {
-  _inherits(TwoBitAdapter, _BaseSequenceAdapter);
-
-  var _super = /*#__PURE__*/_createSuper(TwoBitAdapter);
-
-  function TwoBitAdapter(config, getSubAdapter, pluginManager) {
-    var _this;
-
-    _classCallCheck(this, TwoBitAdapter);
-
-    _this = _super.call(this, config, getSubAdapter, pluginManager);
-    _this.chromSizesData = _this.initChromSizes();
-    _this.twobit = new TwoBitFile({
-      filehandle: openLocation(readConfObject(config, 'twoBitLocation'), _this.pluginManager)
-    });
-    return _this;
-  }
-
-  _createClass(TwoBitAdapter, [{
-    key: "initChromSizes",
-    value: function () {
-      var _initChromSizes = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee() {
-        var conf, file, data;
-        return runtime_1.wrap(function _callee$(_context) {
-          while (1) {
-            switch (_context.prev = _context.next) {
-              case 0:
-                conf = readConfObject(this.config, 'chromSizesLocation'); // check against default and empty in case someone makes the field blank in
-                // config editor, may want better way to check "optional config slots" in
-                // future
-
-                if (!(conf.uri !== '/path/to/default.chrom.sizes' && conf.uri !== '')) {
-                  _context.next = 7;
-                  break;
-                }
-
-                file = openLocation(conf, this.pluginManager);
-                _context.next = 5;
-                return file.readFile('utf8');
-
-              case 5:
-                data = _context.sent;
-                return _context.abrupt("return", Object.fromEntries(data === null || data === void 0 ? void 0 : data.split('\n').filter(function (line) {
-                  return !!line.trim();
-                }).map(function (line) {
-                  var _line$split = line.split('\t'),
-                      _line$split2 = _slicedToArray(_line$split, 2),
-                      name = _line$split2[0],
-                      length = _line$split2[1];
-
-                  return [name, +length];
-                })));
-
-              case 7:
-                return _context.abrupt("return", undefined);
-
-              case 8:
-              case "end":
-                return _context.stop();
-            }
-          }
-        }, _callee, this);
-      }));
-
-      function initChromSizes() {
-        return _initChromSizes.apply(this, arguments);
-      }
-
-      return initChromSizes;
-    }()
-  }, {
-    key: "getRefNames",
-    value: function () {
-      var _getRefNames = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2() {
-        var chromSizesData;
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                _context2.next = 2;
-                return this.chromSizesData;
-
-              case 2:
-                chromSizesData = _context2.sent;
-
-                if (!chromSizesData) {
-                  _context2.next = 5;
-                  break;
-                }
-
-                return _context2.abrupt("return", Object.keys(chromSizesData));
-
-              case 5:
-                return _context2.abrupt("return", this.twobit.getSequenceNames());
-
-              case 6:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function getRefNames() {
-        return _getRefNames.apply(this, arguments);
-      }
-
-      return getRefNames;
-    }()
-  }, {
-    key: "getRegions",
-    value: function () {
-      var _getRegions = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee3() {
-        var chromSizesData, refSizes;
-        return runtime_1.wrap(function _callee3$(_context3) {
-          while (1) {
-            switch (_context3.prev = _context3.next) {
-              case 0:
-                _context3.next = 2;
-                return this.chromSizesData;
-
-              case 2:
-                chromSizesData = _context3.sent;
-
-                if (!chromSizesData) {
-                  _context3.next = 5;
-                  break;
-                }
-
-                return _context3.abrupt("return", Object.keys(chromSizesData).map(function (refName) {
-                  return {
-                    refName: refName,
-                    start: 0,
-                    end: chromSizesData[refName]
-                  };
-                }));
-
-              case 5:
-                _context3.next = 7;
-                return this.twobit.getSequenceSizes();
-
-              case 7:
-                refSizes = _context3.sent;
-                return _context3.abrupt("return", Object.keys(refSizes).map(function (refName) {
-                  return {
-                    refName: refName,
-                    start: 0,
-                    end: refSizes[refName]
-                  };
-                }));
-
-              case 9:
-              case "end":
-                return _context3.stop();
-            }
-          }
-        }, _callee3, this);
-      }));
-
-      function getRegions() {
-        return _getRegions.apply(this, arguments);
-      }
-
-      return getRegions;
-    }()
-    /**
-     * Fetch features for a certain region
-     * @param param -
-     * @returns Observable of Feature objects in the region
-     */
-
-  }, {
-    key: "getFeatures",
-    value: function getFeatures(_ref) {
-      var _this2 = this;
-
-      var refName = _ref.refName,
-          start = _ref.start,
-          end = _ref.end;
-      return ObservableCreate( /*#__PURE__*/function () {
-        var _ref2 = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee4(observer) {
-          var size, regionEnd, seq;
-          return runtime_1.wrap(function _callee4$(_context4) {
-            while (1) {
-              switch (_context4.prev = _context4.next) {
-                case 0:
-                  _context4.next = 2;
-                  return _this2.twobit.getSequenceSize(refName);
-
-                case 2:
-                  size = _context4.sent;
-                  regionEnd = size !== undefined ? Math.min(size, end) : end;
-                  _context4.next = 6;
-                  return _this2.twobit.getSequence(refName, start, regionEnd);
-
-                case 6:
-                  seq = _context4.sent;
-
-                  if (seq) {
-                    observer.next(new SimpleFeature({
-                      id: "".concat(refName, " ").concat(start, "-").concat(regionEnd),
-                      data: {
-                        refName: refName,
-                        start: start,
-                        end: regionEnd,
-                        seq: seq
-                      }
-                    }));
-                  }
-
-                  observer.complete();
-
-                case 9:
-                case "end":
-                  return _context4.stop();
-              }
-            }
-          }, _callee4);
-        }));
-
-        return function (_x) {
-          return _ref2.apply(this, arguments);
-        };
-      }());
-    }
-    /**
-     * called to provide a hint that data tied to a certain region
-     * will not be needed for the forseeable future and can be purged
-     * from caches, etc
-     */
-
-  }, {
-    key: "freeResources",
-    value: function
-      /* { region } */
-    freeResources() {}
-  }]);
-
-  return TwoBitAdapter;
-}(BaseSequenceAdapter);
-
-var TwoBitAdapter$1 = {
-  __proto__: null,
-  'default': TwoBitAdapter
-};
-
-var _default = /*#__PURE__*/function (_BaseAdapter) {
-  _inherits(_default, _BaseAdapter);
-
-  var _super = /*#__PURE__*/_createSuper(_default);
-
-  function _default(config, getSubAdapter, pluginManager) {
-    var _this;
-
-    _classCallCheck(this, _default);
-
-    _this = _super.call(this, config, getSubAdapter, pluginManager);
-    var chromSizesLocation = readConfObject(config, 'chromSizesLocation');
-
-    if (!chromSizesLocation) {
-      throw new Error('must provide chromSizesLocation');
-    }
-
-    var file = openLocation(chromSizesLocation, _this.pluginManager);
-    _this.source = file.toString();
-    _this.refSeqs = _this.init(file);
-    return _this;
-  }
-
-  _createClass(_default, [{
-    key: "init",
-    value: function () {
-      var _init = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee(file) {
-        var data, refSeqs;
-        return runtime_1.wrap(function _callee$(_context) {
-          while (1) {
-            switch (_context.prev = _context.next) {
-              case 0:
-                _context.next = 2;
-                return file.readFile('utf8');
-
-              case 2:
-                data = _context.sent;
-                refSeqs = {};
-
-                if (data.length) {
-                  _context.next = 6;
-                  break;
-                }
-
-                throw new Error("Could not read file ".concat(file.toString()));
-
-              case 6:
-                data.split('\n').forEach(function (line) {
-                  if (line.length) {
-                    var _line$split = line.split('\t'),
-                        _line$split2 = _slicedToArray(_line$split, 2),
-                        name = _line$split2[0],
-                        length = _line$split2[1];
-
-                    refSeqs[name] = +length;
-                  }
-                });
-                return _context.abrupt("return", refSeqs);
-
-              case 8:
-              case "end":
-                return _context.stop();
-            }
-          }
-        }, _callee);
-      }));
-
-      function init(_x) {
-        return _init.apply(this, arguments);
-      }
-
-      return init;
-    }()
-  }, {
-    key: "getRegions",
-    value: function () {
-      var _getRegions = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2() {
-        var refSeqs;
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                _context2.next = 2;
-                return this.refSeqs;
-
-              case 2:
-                refSeqs = _context2.sent;
-                return _context2.abrupt("return", Object.keys(refSeqs).map(function (refName) {
-                  return {
-                    refName: refName,
-                    start: 0,
-                    end: refSeqs[refName]
-                  };
-                }));
-
-              case 4:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function getRegions() {
-        return _getRegions.apply(this, arguments);
-      }
-
-      return getRegions;
-    }()
-  }, {
-    key: "getFeatures",
-    value: function getFeatures() {
-      throw new Error('sequence not available');
-    }
-  }, {
-    key: "getHeader",
-    value: function getHeader() {
-      return {};
-    }
-  }, {
-    key: "freeResources",
-    value: function
-      /* { region } */
-    freeResources() {}
-  }]);
-
-  return _default;
-}(BaseAdapter);
-
-var ChromSizesAdapter = {
-  __proto__: null,
-  'default': _default
-};
-
-var _default$1 = /*#__PURE__*/function (_BaseSequenceAdapter) {
-  _inherits(_default, _BaseSequenceAdapter);
-
-  var _super = /*#__PURE__*/_createSuper(_default);
-
-  function _default(config, getSubAdapter, pluginManager) {
-    var _this;
-
-    _classCallCheck(this, _default);
-
-    _this = _super.call(this, config, getSubAdapter, pluginManager);
-    _this.seqCache = new AbortablePromiseCache({
-      cache: new LRU({
-        maxSize: 200
-      }),
-      fill: function () {
-        var _fill = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee(args, signal) {
-          var refName, start, end;
-          return runtime_1.wrap(function _callee$(_context) {
-            while (1) {
-              switch (_context.prev = _context.next) {
-                case 0:
-                  refName = args.refName, start = args.start, end = args.end;
-                  return _context.abrupt("return", _this.fasta.getSequence(refName, start, end, _objectSpread2(_objectSpread2({}, args), {}, {
-                    signal: signal
-                  })));
-
-                case 2:
-                case "end":
-                  return _context.stop();
-              }
-            }
-          }, _callee);
-        }));
-
-        function fill(_x, _x2) {
-          return _fill.apply(this, arguments);
-        }
-
-        return fill;
-      }()
-    });
-    var fastaLocation = readConfObject(config, 'fastaLocation');
-    var faiLocation = readConfObject(config, 'faiLocation');
-    var fastaOpts = {
-      fasta: openLocation(fastaLocation, _this.pluginManager),
-      fai: openLocation(faiLocation, _this.pluginManager)
-    };
-    _this.fasta = new IndexedFasta(fastaOpts);
-    return _this;
-  }
-
-  _createClass(_default, [{
-    key: "getRefNames",
-    value: function getRefNames(opts) {
-      return this.fasta.getSequenceNames(opts);
-    }
-  }, {
-    key: "getRegions",
-    value: function () {
-      var _getRegions = /*#__PURE__*/_asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee2(opts) {
-        var seqSizes;
-        return runtime_1.wrap(function _callee2$(_context2) {
-          while (1) {
-            switch (_context2.prev = _context2.next) {
-              case 0:
-                _context2.next = 2;
-                return this.fasta.getSequenceSizes(opts);
-
-              case 2:
-                seqSizes = _context2.sent;
-                return _context2.abrupt("return", Object.keys(seqSizes).map(function (refName) {
-                  return {
-                    refName: refName,
-                    start: 0,
-                    end: seqSizes[refName]
-                  };
-                }));
-
-              case 4:
-              case "end":
-                return _context2.stop();
-            }
-          }
-        }, _callee2, this);
-      }));
-
-      function getRegions(_x3) {
-        return _getRegions.apply(this, arguments);
-      }
-
-      return getRegions;
-    }()
-  }, {
-    key: "getFeatures",
-    value: function getFeatures(region, opts) {
-      var _this2 = this;
-
-      var refName = region.refName,
-          start = region.start,
-          end = region.end;
-      return ObservableCreate( /*#__PURE__*/function () {
-        var _ref = _asyncToGenerator( /*#__PURE__*/runtime_1.mark(function _callee3(observer) {
-          var size, regionEnd, chunks, chunkSize, s, e, chunkStart, r, seq;
-          return runtime_1.wrap(function _callee3$(_context3) {
-            while (1) {
-              switch (_context3.prev = _context3.next) {
-                case 0:
-                  _context3.next = 2;
-                  return _this2.fasta.getSequenceSize(refName, opts);
-
-                case 2:
-                  size = _context3.sent;
-                  regionEnd = size !== undefined ? Math.min(size, end) : end;
-                  chunks = [];
-                  chunkSize = 128000;
-                  s = start - start % chunkSize;
-                  e = end + (chunkSize - end % chunkSize);
-
-                  for (chunkStart = s; chunkStart < e; chunkStart += chunkSize) {
-                    r = {
-                      refName: refName,
-                      start: chunkStart,
-                      end: chunkStart + chunkSize
-                    };
-                    chunks.push(_this2.seqCache.get(JSON.stringify(r), r, opts === null || opts === void 0 ? void 0 : opts.signal));
-                  }
-
-                  _context3.next = 11;
-                  return Promise.all(chunks);
-
-                case 11:
-                  seq = _context3.sent.join('').slice(start - s).slice(0, end - start);
-
-                  if (seq) {
-                    observer.next(new SimpleFeature({
-                      id: "".concat(refName, " ").concat(start, "-").concat(regionEnd),
-                      data: {
-                        refName: refName,
-                        start: start,
-                        end: regionEnd,
-                        seq: seq
-                      }
-                    }));
-                  }
-
-                  observer.complete();
-
-                case 14:
-                case "end":
-                  return _context3.stop();
-              }
-            }
-          }, _callee3);
-        }));
-
-        return function (_x4) {
-          return _ref.apply(this, arguments);
-        };
-      }());
-    }
-    /**
-     * called to provide a hint that data tied to a certain region
-     * will not be needed for the forseeable future and can be purged
-     * from caches, etc
-     */
-
-  }, {
-    key: "freeResources",
-    value: function
-      /* { region } */
-    freeResources() {}
-  }]);
-
-  return _default;
-}(BaseSequenceAdapter);
-
-var IndexedFastaAdapter = {
-  __proto__: null,
-  'default': _default$1
-};
-
-var _default$2 = /*#__PURE__*/function (_IndexedFasta) {
-  _inherits(_default, _IndexedFasta);
-
-  var _super = /*#__PURE__*/_createSuper(_default);
-
-  function _default(config, getSubAdapter, pluginManager) {
-    var _this;
-
-    _classCallCheck(this, _default);
-
-    _this = _super.call(this, config, getSubAdapter, pluginManager);
-    var fastaLocation = readConfObject(config, 'fastaLocation');
-    var faiLocation = readConfObject(config, 'faiLocation');
-    var gziLocation = readConfObject(config, 'gziLocation');
-
-    if (!fastaLocation) {
-      throw new Error('must provide fastaLocation');
-    }
-
-    if (!faiLocation) {
-      throw new Error('must provide faiLocation');
-    }
-
-    if (!gziLocation) {
-      throw new Error('must provide gziLocation');
-    }
-
-    var fastaOpts = {
-      fasta: openLocation(fastaLocation, _this.pluginManager),
-      fai: openLocation(faiLocation, _this.pluginManager),
-      gzi: openLocation(gziLocation, _this.pluginManager)
-    };
-    _this.fasta = new BgzipIndexedFasta(fastaOpts);
-    return _this;
-  }
-
-  return _createClass(_default);
-}(_default$1);
-
-var BgzipFastaAdapter = {
-  __proto__: null,
-  'default': _default$2
-};
-
-export default SequencePlugin;
-//# sourceMappingURL=plugin-sequence.esm.js.map