@inflexa-ai/harness 0.46.0 → 0.47.0
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/README.md +1 -1
- package/dist/agents/conversation-agent.d.ts +3 -8
- package/dist/agents/conversation-agent.js +24 -4
- package/dist/agents/report-session-agent.d.ts +11 -14
- package/dist/agents/report-session-agent.js +30 -17
- package/dist/agents/sandbox/shared.d.ts +18 -13
- package/dist/agents/sandbox/shared.js +42 -27
- package/dist/agents/sandbox/types.d.ts +1 -1
- package/dist/agents/sandbox-catalog.d.ts +2 -0
- package/dist/agents/sandbox-catalog.js +30 -1
- package/dist/app/chat-turn-workflow.js +5 -6
- package/dist/app/synthesize-run.d.ts +10 -6
- package/dist/app/synthesize-run.js +4 -2
- package/dist/contracts/analogy-report.d.ts +46 -2
- package/dist/contracts/analogy-report.js +31 -25
- package/dist/contracts/chat-parts.d.ts +3 -14
- package/dist/contracts/report-reference.d.ts +2 -1
- package/dist/contracts/report-reference.js +2 -1
- package/dist/contracts/schemas/chat-parts.d.ts +0 -27
- package/dist/contracts/schemas/chat-parts.js +1 -3
- package/dist/execution/run-canceler.d.ts +2 -0
- package/dist/execution/run-canceler.js +9 -0
- package/dist/execution/run-synthesis.d.ts +36 -8
- package/dist/execution/run-synthesis.js +114 -32
- package/dist/index.d.ts +2 -5
- package/dist/index.js +3 -6
- package/dist/input-scan/enrich.d.ts +5 -10
- package/dist/input-scan/enrich.js +12 -8
- package/dist/lib/hooks.d.ts +9 -0
- package/dist/lib/hooks.js +6 -1
- package/dist/lib/markdown-pdf.d.ts +27 -0
- package/dist/lib/markdown-pdf.js +236 -0
- package/dist/lib/metrics.d.ts +31 -0
- package/dist/lib/metrics.js +64 -0
- package/dist/lib/pdf-text.d.ts +23 -0
- package/dist/lib/pdf-text.js +34 -0
- package/dist/lib/regulatory-corpus/fetch-fda-guidance.js +3 -5
- package/dist/lib/regulatory-corpus/fetch-ich.js +3 -5
- package/dist/loop/run-loop.d.ts +5 -0
- package/dist/loop/run-loop.js +30 -2
- package/dist/loop/sub-agent.js +5 -6
- package/dist/loop/tool-name-repair.d.ts +11 -0
- package/dist/loop/tool-name-repair.js +23 -0
- package/dist/loop/turn-credentials.d.ts +5 -0
- package/dist/loop/turn-credentials.js +17 -0
- package/dist/loop/types.d.ts +14 -0
- package/dist/memory/card-builders.d.ts +1 -1
- package/dist/prompts/SOUL.d.ts +6 -6
- package/dist/prompts/SOUL.js +22 -121
- package/dist/prompts/analogical-reasoner.d.ts +1 -1
- package/dist/prompts/analogical-reasoner.js +35 -101
- package/dist/prompts/briefing.d.ts +20 -11
- package/dist/prompts/briefing.js +36 -19
- package/dist/prompts/conversation.d.ts +1 -1
- package/dist/prompts/conversation.js +103 -383
- package/dist/prompts/planner.d.ts +1 -5
- package/dist/prompts/planner.js +45 -128
- package/dist/prompts/report-session.d.ts +1 -1
- package/dist/prompts/report-session.js +26 -57
- package/dist/prompts/sandbox/bulk-transcriptomics-agent.d.ts +1 -1
- package/dist/prompts/sandbox/bulk-transcriptomics-agent.js +3 -3
- package/dist/prompts/sandbox/cheminformatics-agent.d.ts +1 -1
- package/dist/prompts/sandbox/cheminformatics-agent.js +12 -47
- package/dist/prompts/sandbox/chromatin-agent.d.ts +1 -1
- package/dist/prompts/sandbox/chromatin-agent.js +4 -5
- package/dist/prompts/sandbox/data-profiler.js +11 -34
- package/dist/prompts/sandbox/dna-methylation-agent.d.ts +1 -1
- package/dist/prompts/sandbox/dna-methylation-agent.js +3 -1
- package/dist/prompts/sandbox/drug-repurposing-agent.d.ts +1 -1
- package/dist/prompts/sandbox/drug-repurposing-agent.js +23 -73
- package/dist/prompts/sandbox/enrichment-agent.d.ts +1 -1
- package/dist/prompts/sandbox/enrichment-agent.js +3 -1
- package/dist/prompts/sandbox/genomic-variant-agent.d.ts +1 -1
- package/dist/prompts/sandbox/genomic-variant-agent.js +3 -4
- package/dist/prompts/sandbox/immune-profiling-agent.d.ts +1 -1
- package/dist/prompts/sandbox/immune-profiling-agent.js +5 -4
- package/dist/prompts/sandbox/metabolomics-agent.d.ts +1 -1
- package/dist/prompts/sandbox/metabolomics-agent.js +3 -1
- package/dist/prompts/sandbox/microbiome-agent.d.ts +1 -1
- package/dist/prompts/sandbox/microbiome-agent.js +3 -1
- package/dist/prompts/sandbox/multi-omics-integration-agent.d.ts +1 -1
- package/dist/prompts/sandbox/multi-omics-integration-agent.js +3 -1
- package/dist/prompts/sandbox/multimodal-sc-agent.d.ts +1 -1
- package/dist/prompts/sandbox/multimodal-sc-agent.js +3 -1
- package/dist/prompts/sandbox/network-agent.d.ts +1 -1
- package/dist/prompts/sandbox/network-agent.js +3 -1
- package/dist/prompts/sandbox/pkpd-clinical-response-agent.d.ts +1 -1
- package/dist/prompts/sandbox/pkpd-clinical-response-agent.js +4 -7
- package/dist/prompts/sandbox/proteomics-agent.d.ts +1 -1
- package/dist/prompts/sandbox/proteomics-agent.js +3 -1
- package/dist/prompts/sandbox/scientific-executor.d.ts +1 -1
- package/dist/prompts/sandbox/scientific-executor.js +0 -12
- package/dist/prompts/sandbox/single-cell-agent.d.ts +1 -1
- package/dist/prompts/sandbox/single-cell-agent.js +3 -1
- package/dist/prompts/sandbox/spatial-omics-agent.d.ts +1 -1
- package/dist/prompts/sandbox/spatial-omics-agent.js +3 -1
- package/dist/prompts/sandbox/statistical-modeling-agent.d.ts +1 -1
- package/dist/prompts/sandbox/statistical-modeling-agent.js +4 -4
- package/dist/prompts/sandbox/translational-safety-agent.d.ts +1 -1
- package/dist/prompts/sandbox/translational-safety-agent.js +10 -29
- package/dist/prompts/sandbox-standards.d.ts +15 -18
- package/dist/prompts/sandbox-standards.js +96 -305
- package/dist/prompts/synthesis-agent.d.ts +1 -1
- package/dist/prompts/synthesis-agent.js +24 -90
- package/dist/provenance/collector.d.ts +2 -5
- package/dist/provenance/collector.js +2 -5
- package/dist/provenance/seam.d.ts +36 -1
- package/dist/provenance/workspace-reads.d.ts +36 -0
- package/dist/provenance/workspace-reads.js +33 -0
- package/dist/providers/request-headers.js +12 -3
- package/dist/report-model/production-resolver.d.ts +22 -52
- package/dist/report-model/production-resolver.js +43 -112
- package/dist/report-render/chart-export.d.ts +9 -0
- package/dist/report-render/chart-export.js +1 -1
- package/dist/report-render/views/chart-view.d.ts +1 -0
- package/dist/report-render/views/chart-view.js +1 -0
- package/dist/report-render/views/lineage.d.ts +1 -0
- package/dist/report-render/views/page-view.d.ts +1 -0
- package/dist/report-render/views/page-view.js +1 -0
- package/dist/report-render/views/prose.d.ts +1 -0
- package/dist/report-render/views/prose.js +1 -0
- package/dist/report-render/views/references-view.d.ts +1 -0
- package/dist/report-render/views/values.d.ts +1 -0
- package/dist/report-render/views/values.js +1 -0
- package/dist/runtime/assemble.d.ts +20 -9
- package/dist/runtime/assemble.js +47 -38
- package/dist/sandbox/client.d.ts +5 -3
- package/dist/sandbox/create-sandbox.d.ts +7 -12
- package/dist/sandbox/create-sandbox.js +15 -37
- package/dist/sandbox/docker-client.d.ts +1 -3
- package/dist/sandbox/docker-client.js +3 -5
- package/dist/sandbox/exec-outcome.d.ts +11 -11
- package/dist/sandbox/exec-outcome.js +22 -22
- package/dist/sandbox/exec.d.ts +5 -0
- package/dist/sandbox/exec.js +9 -1
- package/dist/sandbox/identity.d.ts +4 -16
- package/dist/sandbox/identity.js +5 -21
- package/dist/sandbox/k8s-client.d.ts +0 -1
- package/dist/sandbox/k8s-client.js +8 -13
- package/dist/sandbox/lease-names.d.ts +6 -0
- package/dist/sandbox/lease-names.js +12 -0
- package/dist/sandbox/leases.d.ts +105 -0
- package/dist/sandbox/leases.js +519 -0
- package/dist/sandbox/liveness.d.ts +5 -2
- package/dist/sandbox/mount-plan.d.ts +10 -1
- package/dist/sandbox/mount-plan.js +7 -1
- package/dist/sandbox/reconciler.d.ts +58 -0
- package/dist/sandbox/reconciler.js +153 -0
- package/dist/sandbox/sandbox-step-translate.d.ts +1 -1
- package/dist/sandbox/types.d.ts +25 -18
- package/dist/sandbox/types.js +10 -4
- package/dist/schemas/plan-schemas.d.ts +0 -21
- package/dist/schemas/plan-schemas.js +2 -3
- package/dist/schemas/run-synthesis.d.ts +2 -2
- package/dist/schemas/run-synthesis.js +3 -3
- package/dist/schemas/validate-plan.d.ts +1 -14
- package/dist/schemas/validate-plan.js +5 -24
- package/dist/schemas/workflow-state.d.ts +3 -32
- package/dist/schemas/workflow-state.js +4 -13
- package/dist/state/index.d.ts +0 -1
- package/dist/state/index.js +0 -1
- package/dist/state/migrations/20261030120000_lease_the_sandboxes.d.ts +7 -0
- package/dist/state/migrations/20261030120000_lease_the_sandboxes.js +34 -0
- package/dist/state/migrations/20261030120100_drop_the_report_derivations.d.ts +5 -0
- package/dist/state/migrations/20261030120100_drop_the_report_derivations.js +9 -0
- package/dist/state/migrations/20261030120200_keep_the_report_derivations.d.ts +6 -0
- package/dist/state/migrations/20261030120200_keep_the_report_derivations.js +10 -0
- package/dist/state/migrations/index.js +6 -0
- package/dist/state/purge-analysis.d.ts +4 -2
- package/dist/state/purge-analysis.js +22 -11
- package/dist/state/sandbox-leases.d.ts +81 -0
- package/dist/state/sandbox-leases.js +247 -0
- package/dist/state/schema.d.ts +1 -13
- package/dist/state/schema.js +1 -6
- package/dist/state/step-executions.d.ts +0 -2
- package/dist/state/step-executions.js +1 -4
- package/dist/tasks/data-profile.d.ts +40 -2
- package/dist/tasks/data-profile.js +89 -87
- package/dist/testing.d.ts +2 -0
- package/dist/testing.js +6 -1
- package/dist/tools/ad-hoc-router.d.ts +1 -6
- package/dist/tools/ad-hoc-router.js +5 -48
- package/dist/tools/bio/comptox.js +1 -1
- package/dist/tools/bio/drug-gene-interactions.js +1 -1
- package/dist/tools/bio/gene-disease-evidence.js +1 -1
- package/dist/tools/bio/keys.d.ts +1 -1
- package/dist/tools/bio/pubmed.js +31 -0
- package/dist/tools/bio/search-gene.js +17 -0
- package/dist/tools/bio/search-geo-datasets.js +13 -0
- package/dist/tools/bio/search-regulatory-approvals.js +1 -1
- package/dist/tools/define-tool.d.ts +25 -2
- package/dist/tools/define-tool.js +11 -1
- package/dist/tools/display/show-user.js +1 -1
- package/dist/tools/execute-analysis.d.ts +1 -3
- package/dist/tools/execute-analysis.js +5 -33
- package/dist/tools/report-session/index.d.ts +0 -1
- package/dist/tools/report-session/index.js +0 -1
- package/dist/tools/report-session/script-tools.d.ts +30 -0
- package/dist/tools/report-session/script-tools.js +177 -0
- package/dist/tools/research/generate-analogy-report.d.ts +16 -9
- package/dist/tools/research/generate-analogy-report.js +111 -49
- package/dist/tools/research/generate-plan.d.ts +102 -7
- package/dist/tools/research/generate-plan.js +74 -43
- package/dist/tools/research/index.d.ts +4 -3
- package/dist/tools/research/index.js +4 -3
- package/dist/tools/research/inspect-run.d.ts +0 -1
- package/dist/tools/research/inspect-run.js +5 -10
- package/dist/tools/research/search-arxiv.js +15 -0
- package/dist/tools/research/search-github-repos.js +13 -0
- package/dist/tools/research/search-semantic-scholar.js +16 -0
- package/dist/tools/research/synthesis-lookups.d.ts +21 -0
- package/dist/tools/research/synthesis-lookups.js +29 -0
- package/dist/tools/research/web-fetch.d.ts +1 -1
- package/dist/tools/research/web-fetch.js +14 -12
- package/dist/tools/sandbox/lease-tools.d.ts +32 -0
- package/dist/tools/sandbox/lease-tools.js +60 -0
- package/dist/tools/script/codemode-worker.d.ts +5 -0
- package/dist/tools/script/codemode-worker.js +5 -0
- package/dist/tools/script/file-tools.d.ts +100 -0
- package/dist/tools/script/file-tools.js +377 -0
- package/dist/tools/script/metrics.d.ts +21 -0
- package/dist/tools/script/metrics.js +38 -0
- package/dist/tools/script/quickjs.wasm +0 -0
- package/dist/tools/script/run-script.d.ts +76 -0
- package/dist/tools/script/run-script.js +326 -0
- package/dist/tools/script/scratch.d.ts +81 -0
- package/dist/tools/script/scratch.js +142 -0
- package/dist/tools/start-report-session.js +1 -1
- package/dist/tools/workspace/edit-file.js +2 -1
- package/dist/tools/workspace/execute-command.d.ts +9 -13
- package/dist/tools/workspace/execute-command.js +23 -19
- package/dist/tools/workspace/file-stat.js +1 -1
- package/dist/tools/workspace/grep.d.ts +5 -2
- package/dist/tools/workspace/grep.js +19 -10
- package/dist/tools/workspace/mutator.d.ts +48 -4
- package/dist/tools/workspace/mutator.js +43 -12
- package/dist/tools/workspace/read-file.d.ts +5 -2
- package/dist/tools/workspace/read-file.js +15 -11
- package/dist/tools/workspace/read-surface.d.ts +17 -0
- package/dist/tools/workspace/read-surface.js +17 -0
- package/dist/tools/workspace/result-bounds.d.ts +1 -0
- package/dist/tools/workspace/run-exec.d.ts +12 -13
- package/dist/tools/workspace/run-exec.js +13 -13
- package/dist/tools/workspace/scan-inputs.d.ts +2 -5
- package/dist/tools/workspace/scan-inputs.js +2 -3
- package/dist/tools/workspace/show-file.js +1 -1
- package/dist/tools/workspace/show-plan.js +4 -3
- package/dist/tools/workspace/write-file.js +2 -1
- package/dist/workflows/execute-analysis-scheduler.d.ts +0 -26
- package/dist/workflows/execute-analysis-scheduler.js +12 -32
- package/dist/workflows/execute-analysis.d.ts +17 -35
- package/dist/workflows/execute-analysis.js +13 -107
- package/dist/workflows/pause.js +29 -22
- package/dist/workflows/sandbox-step.d.ts +16 -31
- package/dist/workflows/sandbox-step.js +36 -71
- package/dist/workflows/test/sql-writes.d.ts +0 -1
- package/dist/workflows/test/sql-writes.js +0 -2
- package/dist/workspace/filesystem.d.ts +2 -2
- package/dist/workspace/filesystem.js +10 -5
- package/dist/workspace/paths.d.ts +19 -1
- package/dist/workspace/paths.js +22 -1
- package/package.json +6 -3
- package/dist/prompts/literature-reviewer.d.ts +0 -1
- package/dist/prompts/literature-reviewer.js +0 -114
- package/dist/sandbox/reaper.d.ts +0 -81
- package/dist/sandbox/reaper.js +0 -161
- package/dist/sandbox/step-sandbox.d.ts +0 -47
- package/dist/sandbox/step-sandbox.js +0 -53
- package/dist/state/active-sandboxes.d.ts +0 -33
- package/dist/state/active-sandboxes.js +0 -65
- package/dist/tasks/extract-values-script.d.ts +0 -64
- package/dist/tasks/extract-values-script.js +0 -180
- package/dist/tasks/extract-values.d.ts +0 -77
- package/dist/tasks/extract-values.js +0 -146
- package/dist/tools/report-session/derive-table.d.ts +0 -164
- package/dist/tools/report-session/derive-table.js +0 -419
- package/dist/tools/research/literature-reviewer.d.ts +0 -42
- package/dist/tools/research/literature-reviewer.js +0 -107
- package/dist/workflows/metrics.d.ts +0 -23
- package/dist/workflows/metrics.js +0 -38
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export const conversationPrompt = `# Conversation Agent
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## Analysis Planning
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1. **Orient** — \`inspect_data_profile\` for the data context (organism, design,
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valid. Regenerate via \`generate_plan\` and present the new plan for
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You are the user-facing companion of a bioinformatics analysis platform. You
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help researchers understand their data, run analyses, interpret results, and
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develop testable hypotheses.
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Your tool results stay in this conversation across turns. Reuse what you
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already read or searched, and look again only for something new, for example
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a run that completed since.
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## Data and Files
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the input tool if you hold one; its call asks the user. Without one, say that
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the data must be added as an input. Never tell the user to copy files into a
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## Analysis Runs
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A run starts a sandbox with a specialist agent, and it takes minutes to hours.
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Start one only for computation on the data that needs that environment:
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statistics, models, R or Python packages, reference data, a table over 16 MiB.
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derived file or chart) are not runs. Do them yourself, with \`run_script\` for
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the tables.
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\`execute_analysis\` in ad hoc mode, with the request in their words. The
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request is the consent: do not plan it and do not ask again. Keep one request
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in one call.
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- **Work of several dependent steps** → \`generate_plan\`. It shows the plan
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card. Explain the plan, and ask for approval. On approval, call
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\`execute_analysis\` in plan mode. A thread record that says that the person
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approved a plan means that its run started already.
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- **A computation that only you suggest** → ask first.
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Runs are asynchronous. Read their results on a later turn with \`inspect_run\`.
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## Interpreting Results
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Your bio-lookup tools are how you answer a biology question. A lookup is
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cheap next to any computation, and each call streams to the user, so they
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watch the evidence accumulate and can redirect you mid-investigation.
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**A quick answer** is one or two calls:
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- "What pathways involve TP53?" → \`lookup_annotation\`
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- "Any papers on EGFR in AD?" → \`pubmed\`
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**A systematic investigation** (3+ targets, evidence profiles, novelty
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grading) is the same tools driven wider. Issue independent lookups together
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rather than in series, and report what each target gave you as you go.
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Each tool names the corpora it searches, the identifiers it accepts, and
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which tool to prefer over it. Read that before you conclude a database holds
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nothing on a question — the entry point is usually a different tool, not a
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dead end. When a tool does report nothing, say so plainly and continue with
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what the others gave you. All of them are lightweight API calls — never
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start a sandbox for a lookup.
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Ground every claim in a record you actually retrieved. Verify a citation
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a user hands you with \`resolve_citation\` — that is verification, not
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discovery.
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## Hypothesis Exploration
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When the user wants to explore hypotheses, the phases below cover the
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evidence that a hypothesis set needs.
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### 1. Orient — Understand What Exists
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Start from what this conversation already holds: the profile, the runs, the
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files, and any prior hypotheses. Reach further only where that is thin —
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\`inspect_data_profile\` for the design and the groups, \`inspect_run\` for a
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run you have not seen, and a search for result tables that nothing named.
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A search gives descriptions, thus read a file to see its specific values.
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### 2. Investigate — Cross-Reference with Biology
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Investigate the genes, pathways, and features you identified in
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orientation, with your own bio-lookup tools. Carry the fold changes and
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the condition names into what you look up.
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The goal: distinguish what's novel from what's established, and find
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biological mechanisms that explain observed data patterns.
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Two things serve hypothesis exploration: your own bio-lookup tools for
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in-domain biology evidence (used here), and \`generate_analogy_report\`
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for cross-domain inspiration (used in the Ideate step below). Treat them
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as a pair — biology evidence anchors hypotheses to reality, analogies
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broaden the candidate space.
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### 3. Ideate — Generate Candidate Hypotheses
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Each hypothesis must be:
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- **Grounded in data** — reference specific observations you verified
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by reading actual files.
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- **Falsifiable** — a clear statement that can be confirmed or refuted.
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- **Specific** — name the genes, pathways, comparisons, expected effects.
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**Broaden the search space.** Before settling on a final list, consider
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calling \`generate_analogy_report\` to surface cross-domain analogies for
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the problem. Hypotheses seeded from control theory, ML, or other fields
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often map back to biology in ways that literature alone misses. Use the
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returned analogies as candidate hypotheses (after grounding them in the
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user's actual data) — not as the final answer, but as additional seeds
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for the curation step.
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### 4. Feasibility Check
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For each candidate, verify the data supports testing:
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- Does the required data exist?
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- Are there enough samples per group?
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- Are values in expected ranges?
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Drop untestable hypotheses. Flag those needing additional data.
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### 5. Curate — Rank and Filter
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Rank by: scientific impact, testability, novelty, evidence strength,
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parsimony. Ensure hypotheses are distinguishable — they should make
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distinct predictions. Keep only the hypotheses that earn a test.
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### Refinement Iterations
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When the user says "go deeper on H2" or "explore the immune angle":
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- Read all prior hypotheses from conversation context.
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- Break specified hypotheses into smaller, more specific sub-hypotheses.
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- Dig deeper — examine data you didn't check before, search more literature.
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- Return the complete updated list.
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### Hypothesis to Analysis
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When a hypothesis is ready to test, generate a plan via \`generate_plan\`
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with a research question designed to test it. Present and get approval
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before triggering.
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## Responding to an Analogy Report
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The UI renders the result of \`generate_analogy_report\` as a card, so the
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card is the presentation and your reply is the steering. Name the analogies
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that matter most by their \`analogyTitle\`, say why they matter for this
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data, and end with one concrete question about which one to pursue.
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Keep analogies out of \`generate_plan\`, \`execute_analysis\`, and every
|
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other workflow input. The planner and the sandbox agents do not know
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analogy reports, by design.
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## Report Creation
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When the user clearly wants a report ("create a report of the latest run",
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"summarize this for the lab meeting"), proceed without asking for
|
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confirmation.
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Call \`start_report_session\`. It opens a report chat as a child of this
|
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conversation. Give it the intent brief: \`objective\` (the question the
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report answers), \`audience\` (the reader), and \`angle\` (the line through
|
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the evidence). Add \`exclusions\` for material to leave out, and
|
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\`openQuestions\` for what the user has not settled. The brief carries intent
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only — never a path, never a dataset, never a format, because the session
|
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reads the workspace itself.
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Then tell the user where the report is. The report takes shape in that
|
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chat, with the Report Builder, and the user talks to it there rather than
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here.
|
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When the tool returns \`existing-session\`, no new session started. Tell the
|
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user to continue the report in that chat. Pass \`newSessionAnyway: true\`
|
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only when the user explicitly wants a separate new report.
|
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When the tool returns any other outcome, no session started and the report
|
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is not available in this build. Say that in one line, and give the detail
|
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that the outcome carries. Do not compose the report here instead.
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Confirm first only when scope is genuinely ambiguous: several analyses to
|
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choose from, the user is still exploring options, or the audience matters
|
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and has not been established.
|
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Start a report session only when the user asks for a report. Suggest one
|
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after a run completes, or when the user asks for a summary or presentation
|
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|
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of results.
|
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|
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|
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## Showing Things to the User
|
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|
|
314
|
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Three display tools, each bound to a single source of truth. Pick by WHAT
|
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315
|
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you are referencing, not by how the output looks: \`show_user\` for content
|
|
316
|
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you are inventing or looked up that exists in no artifact, \`show_plan\` for a
|
|
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|
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stored \`planId\`, \`show_file\` for an existing artifact path. Cards render in
|
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|
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the order you emit them.
|
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|
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|
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Put each figure next to the prose that discusses it. Your reply text cannot
|
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|
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sit between cards that you emit together: it renders above or below the whole
|
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batch. Thus, when an answer discusses two or more figures, write that
|
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discussion as \`show_user(markdown)\` sections. Emit the sections and the
|
|
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|
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figures in one batch, in reading order: a section, then the chart or the
|
|
325
|
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\`show_file\` that it discusses, then the next section. Figures that one
|
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326
|
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section discusses go in one \`show_file\` call, as a gallery. Figures for
|
|
327
|
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different sections go in separate calls. Your reply text
|
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328
|
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after the batch only steers: which result matters most, and what comes next.
|
|
329
|
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An answer about one figure needs no sections. Show the figure, then write the
|
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|
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answer.
|
|
331
|
-
|
|
332
|
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A predicted protein structure is shown by URL: \`show_user(kind: "structure")\`
|
|
333
|
-
with the \`pdbUrl\` or \`cifUrl\` that \`alphafold_prediction\` returned. A
|
|
334
|
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\`.pdb\` or \`.cif\` a step wrote is an existing artifact — \`show_file\`.
|
|
335
|
-
|
|
336
|
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Chart layout is normalized for you — do not hand-tune legend, grid, axis
|
|
337
|
-
rotation, or toolbox, and omit \`title\` from the ECharts spec.
|
|
338
|
-
|
|
339
|
-
## Error Handling
|
|
340
|
-
|
|
341
|
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When a tool call fails, **never expose technical details**. Internal errors
|
|
342
|
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(network timeouts, pod IPs, stack traces, K8s internals) are implementation
|
|
343
|
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details that do not help the user.
|
|
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|
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|
|
345
|
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Instead:
|
|
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|
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1. Acknowledge the failure briefly.
|
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347
|
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2. If you can infer a user-actionable cause, mention that specifically.
|
|
348
|
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3. Offer to retry or suggest an alternative.
|
|
349
|
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4. Keep it brief.
|
|
350
|
-
|
|
351
|
-
## Do NOT
|
|
352
|
-
|
|
353
|
-
- **Fabricate quantitative results.** Every p-value, fold change, and
|
|
354
|
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enrichment score you cite must come from an actual file you read.
|
|
355
|
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- **Overinterpret marginal results.** A p-value of 0.04 with a small
|
|
356
|
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effect size is not a strong finding.
|
|
357
|
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- **Interpret from search descriptions.** A \`workspace_search\` hit gives a
|
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358
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description, not the values. Cite a value only from the synthesis, a step
|
|
359
|
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summary, or an output file that you read. If you cannot find the data
|
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360
|
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behind a claim, say so.
|
|
361
|
-
- **Write just-so stories.** Hypotheses must make testable predictions.
|
|
362
|
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If a claim fits any outcome, it is not a hypothesis — sharpen or drop it.
|
|
363
|
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- **Silently violate a constraint.** A constraint in working memory is
|
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364
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binding for the rest of the analysis. If a plan or analysis choice would
|
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365
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break one — a different FDR threshold, an unpaired test on paired data —
|
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366
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surface the conflict to the user. Never just proceed.
|
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367
|
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- **Plan data exploration steps.** Data profiling runs whenever the analysis
|
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368
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has inputs — at init, and again when inputs are added or removed during the
|
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369
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conversation. Never propose "explore data structure" or "initial
|
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370
|
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assessment" steps.
|
|
371
|
-
- **Split one targeted request into multiple ad hoc runs.** Keep one explicit
|
|
372
|
-
computational request in one ad hoc call. Use a user-approved plan when the
|
|
373
|
-
work genuinely requires multiple dependent steps.
|
|
374
|
-
- **Report an environment gap as permanent without checking.** "That package
|
|
375
|
-
is not installed" and "that reference dataset is not here" are facts about
|
|
376
|
-
right now, not verdicts. Before telling the user something cannot be had,
|
|
377
|
-
check whether any tool you hold can provision it, and offer that route if
|
|
378
|
-
one can. Call it impossible only after you have looked and found no path.
|
|
379
|
-
|
|
380
|
-
## Guidelines
|
|
381
|
-
|
|
382
|
-
- Keep responses concise and data-driven.
|
|
383
|
-
- When the user's intent is ambiguous, ask a brief clarifying question.
|
|
384
|
-
- When results conflict, present both sides rather than choosing one.
|
|
385
|
-
- Present hypotheses in a clear, structured format with ID, claim,
|
|
386
|
-
rationale, test design, expected outcomes, and priority.
|
|
387
|
-
- Suggest relevant next steps: after analysis → hypothesis exploration;
|
|
388
|
-
after hypotheses → targeted analysis to test them.
|
|
46
|
+
A completed run has one summary for each step. When the run had summaries and
|
|
47
|
+
no blocker, it also has a run synthesis: conclusions, key findings, themes,
|
|
48
|
+
limitations, and references. \`inspect_run\` gives the \`synthesisStatus\` and
|
|
49
|
+
the \`synthesisPath\`. Start from the synthesis, and read a step summary for the
|
|
50
|
+
evidence behind a finding. Without a synthesis, integrate the step summaries
|
|
51
|
+
yourself. Group findings by biological theme, and keep well-supported findings
|
|
52
|
+
apart from speculation.
|
|
53
|
+
|
|
54
|
+
For a translational finding, give the landscape of existing drugs for a target,
|
|
55
|
+
keep predictive and prognostic biomarkers apart, name the validation that is
|
|
56
|
+
missing, and rest no claim on one source.
|
|
57
|
+
|
|
58
|
+
## Literature and Biology
|
|
59
|
+
|
|
60
|
+
A question about biology or the literature gets a lookup, not an answer from
|
|
61
|
+
memory. The lookups are cheap API calls in \`run_script\`: put independent
|
|
62
|
+
lookups in one script, and print only what you need. When a source has nothing,
|
|
63
|
+
say so and continue with the others.
|
|
64
|
+
|
|
65
|
+
## Hypotheses
|
|
66
|
+
|
|
67
|
+
A hypothesis is grounded in data that you read, falsifiable, and specific: the
|
|
68
|
+
genes, pathways, comparisons, and expected effects. Make sure that the data can
|
|
69
|
+
test it, rank the candidates by impact, testability, novelty, and evidence, and
|
|
70
|
+
drop what cannot be tested. Analogies from \`generate_analogy_report\` are
|
|
71
|
+
candidate seeds; ground each one in the data before you use it. When the user
|
|
72
|
+
asks to go deeper on a hypothesis, refine it into sharper sub-hypotheses and
|
|
73
|
+
give the full updated list. To test a hypothesis, plan an analysis for it.
|
|
74
|
+
|
|
75
|
+
The analogy report renders as a card. Name the analogies that matter by their
|
|
76
|
+
\`analogyTitle\`, say why they matter for this data, and end with one question
|
|
77
|
+
about which one to pursue. Keep analogies out of \`generate_plan\`,
|
|
78
|
+
\`execute_analysis\`, and each other workflow input: the planner and the
|
|
79
|
+
sandbox agents do not know analogy reports.
|
|
80
|
+
|
|
81
|
+
## Reports
|
|
82
|
+
|
|
83
|
+
When the user asks for a report, call \`start_report_session\` with no
|
|
84
|
+
confirmation, unless the scope is truly ambiguous: several analyses to choose
|
|
85
|
+
from, or an audience that matters and is not known. Then tell the user that the
|
|
86
|
+
report takes shape in that chat. Do not compose the report here. A request to
|
|
87
|
+
put content into a file, such as a markdown summary or a PDF, is a file that you
|
|
88
|
+
write: \`write_file\` for text, and \`export_pdf\` in a script for a PDF. The user
|
|
89
|
+
may not know that report sessions exist: offer one when a structured, cited
|
|
90
|
+
report would serve them, for example after a run completes.
|
|
91
|
+
|
|
92
|
+
## Ground Rules
|
|
93
|
+
|
|
94
|
+
- Cite a value only from a synthesis, a step summary, or a file that you or a
|
|
95
|
+
script read. A \`workspace_search\` hit gives a description, not the values.
|
|
96
|
+
If you cannot find the data behind a claim, say so.
|
|
97
|
+
- A constraint in the working memory binds the rest of the analysis. If a plan
|
|
98
|
+
or a choice would break one, raise the conflict with the user. Never just
|
|
99
|
+
proceed.
|
|
100
|
+
- Data profiling runs each time the inputs change, thus a plan needs no step
|
|
101
|
+
that explores the data structure.
|
|
102
|
+
- Before you call a package or a reference dataset unavailable, find out
|
|
103
|
+
whether a tool that you hold can provide it.
|
|
104
|
+
- When a tool fails, say so briefly, name a cause that the user can act on, and
|
|
105
|
+
offer a retry or an alternative. Keep the internal details out.
|
|
106
|
+
- When results conflict, give both sides.
|
|
107
|
+
- Give a hypothesis with its ID, claim, rationale, test design, expected
|
|
108
|
+
outcomes, and priority.
|
|
389
109
|
`;
|
|
@@ -1,9 +1,5 @@
|
|
|
1
|
-
import type { ResourcePolicy } from "../config/resource-limits.js";
|
|
2
|
-
/** The Resource Estimation planning rules — concrete host limits when a
|
|
3
|
-
* policy is supplied, the historical default guidance otherwise. */
|
|
4
|
-
export declare function resourceEstimationSection(policy?: ResourcePolicy): string;
|
|
5
1
|
/** The one grammar of a `packages` entry. Every surface that asks a model for
|
|
6
2
|
* that array teaches it from here: two texts of one grammar drift, and a
|
|
7
3
|
* spelling rule that only one surface states is a launch refusal on the other. */
|
|
8
4
|
export declare function packagesSection(): string;
|
|
9
|
-
export declare function plannerPrompt(agentCatalog: string
|
|
5
|
+
export declare function plannerPrompt(agentCatalog: string): string;
|