@inflexa-ai/harness 0.28.1 → 0.30.0

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  1. package/dist/agents/conversation-agent.js +7 -4
  2. package/dist/agents/report-session-agent.js +1 -1
  3. package/dist/agents/sandbox/data-profiler.js +0 -1
  4. package/dist/agents/sandbox/immune-profiling-agent.js +3 -1
  5. package/dist/agents/sandbox/network-agent.js +0 -1
  6. package/dist/agents/sandbox/types.d.ts +1 -1
  7. package/dist/agents/sandbox/types.js +1 -1
  8. package/dist/app/data-profile-orientation.d.ts +52 -27
  9. package/dist/app/data-profile-orientation.js +331 -92
  10. package/dist/app/data-profile-view.d.ts +70 -0
  11. package/dist/app/data-profile-view.js +123 -0
  12. package/dist/app/synthesize-run.js +1 -1
  13. package/dist/config/resource-limits.d.ts +1 -1
  14. package/dist/config/resource-limits.js +1 -1
  15. package/dist/contracts/data-profile.d.ts +276 -25
  16. package/dist/contracts/index.d.ts +3 -1
  17. package/dist/contracts/index.js +1 -0
  18. package/dist/contracts/profile-vocabulary.d.ts +103 -0
  19. package/dist/contracts/profile-vocabulary.js +449 -0
  20. package/dist/contracts/schemas/chat-parts.d.ts +12 -12
  21. package/dist/contracts/severity.d.ts +2 -2
  22. package/dist/contracts/target-dossier.d.ts +91 -91
  23. package/dist/data/safety-panel-schema.d.ts +4 -4
  24. package/dist/execution/input-signature.d.ts +16 -3
  25. package/dist/execution/input-signature.js +0 -0
  26. package/dist/execution/post-step-pipeline.js +1 -1
  27. package/dist/execution/staged-input.d.ts +4 -4
  28. package/dist/index.d.ts +7 -2
  29. package/dist/index.js +14 -0
  30. package/dist/input-scan/clustering.d.ts +63 -0
  31. package/dist/input-scan/clustering.js +208 -0
  32. package/dist/input-scan/companions.d.ts +30 -0
  33. package/dist/input-scan/companions.js +138 -0
  34. package/dist/input-scan/decoder/container_readout.py +171 -0
  35. package/dist/input-scan/detect-sets.d.ts +24 -0
  36. package/dist/input-scan/detect-sets.js +279 -0
  37. package/dist/input-scan/enrich.d.ts +62 -19
  38. package/dist/input-scan/enrich.js +132 -187
  39. package/dist/input-scan/formats.d.ts +13 -5
  40. package/dist/input-scan/formats.js +13 -5
  41. package/dist/input-scan/index.d.ts +10 -4
  42. package/dist/input-scan/index.js +7 -4
  43. package/dist/input-scan/markers.d.ts +21 -0
  44. package/dist/input-scan/markers.js +89 -0
  45. package/dist/input-scan/menu.d.ts +127 -0
  46. package/dist/input-scan/menu.js +0 -0
  47. package/dist/input-scan/quarantine.d.ts +17 -0
  48. package/dist/input-scan/quarantine.js +69 -0
  49. package/dist/input-scan/readout-budget.d.ts +32 -0
  50. package/dist/input-scan/readout-budget.js +61 -0
  51. package/dist/input-scan/readout.d.ts +33 -0
  52. package/dist/input-scan/readout.js +336 -0
  53. package/dist/input-scan/scan.d.ts +5 -4
  54. package/dist/input-scan/scan.js +5 -5
  55. package/dist/input-scan/set-types.d.ts +209 -0
  56. package/dist/input-scan/set-types.js +15 -0
  57. package/dist/input-scan/templates.d.ts +93 -0
  58. package/dist/input-scan/templates.js +369 -0
  59. package/dist/input-scan/tokens.d.ts +94 -0
  60. package/dist/input-scan/tokens.js +267 -0
  61. package/dist/input-scan/tuning.d.ts +55 -0
  62. package/dist/input-scan/tuning.js +55 -0
  63. package/dist/input-scan/types.d.ts +2 -2
  64. package/dist/loop/run-agent.d.ts +13 -1
  65. package/dist/loop/run-agent.js +2 -1
  66. package/dist/prompts/SOUL.d.ts +2 -2
  67. package/dist/prompts/SOUL.js +17 -1
  68. package/dist/prompts/conversation.d.ts +1 -1
  69. package/dist/prompts/conversation.js +45 -71
  70. package/dist/prompts/planner.js +57 -10
  71. package/dist/prompts/report-session.d.ts +1 -1
  72. package/dist/prompts/report-session.js +3 -2
  73. package/dist/prompts/sandbox/bulk-transcriptomics-agent.d.ts +1 -1
  74. package/dist/prompts/sandbox/bulk-transcriptomics-agent.js +3 -1
  75. package/dist/prompts/sandbox/data-profiler.d.ts +10 -1
  76. package/dist/prompts/sandbox/data-profiler.js +197 -53
  77. package/dist/prompts/sandbox/dna-methylation-agent.d.ts +1 -1
  78. package/dist/prompts/sandbox/dna-methylation-agent.js +18 -12
  79. package/dist/prompts/sandbox/immune-profiling-agent.d.ts +1 -1
  80. package/dist/prompts/sandbox/immune-profiling-agent.js +6 -2
  81. package/dist/prompts/sandbox/metabolomics-agent.d.ts +1 -1
  82. package/dist/prompts/sandbox/metabolomics-agent.js +8 -4
  83. package/dist/prompts/sandbox/microbiome-agent.d.ts +1 -1
  84. package/dist/prompts/sandbox/microbiome-agent.js +12 -6
  85. package/dist/prompts/sandbox/network-agent.d.ts +1 -1
  86. package/dist/prompts/sandbox/network-agent.js +9 -6
  87. package/dist/prompts/sandbox/spatial-omics-agent.d.ts +1 -1
  88. package/dist/prompts/sandbox/spatial-omics-agent.js +4 -2
  89. package/dist/prompts/sandbox-standards.d.ts +1 -1
  90. package/dist/prompts/sandbox-standards.js +10 -7
  91. package/dist/providers/ai-sdk.js +34 -1
  92. package/dist/providers/reasoning.d.ts +65 -0
  93. package/dist/providers/reasoning.js +81 -0
  94. package/dist/providers/types.d.ts +14 -0
  95. package/dist/schemas/data-profile-schemas.d.ts +947 -84
  96. package/dist/schemas/data-profile-schemas.js +300 -115
  97. package/dist/schemas/run-synthesis.d.ts +4 -4
  98. package/dist/state/data-profile.d.ts +1 -1
  99. package/dist/state/index.d.ts +1 -1
  100. package/dist/state/vector-store.d.ts +13 -0
  101. package/dist/state/vector-store.js +8 -0
  102. package/dist/tasks/data-profile-absorb.d.ts +78 -0
  103. package/dist/tasks/data-profile-absorb.js +285 -0
  104. package/dist/tasks/data-profile-index.d.ts +34 -25
  105. package/dist/tasks/data-profile-index.js +160 -59
  106. package/dist/tasks/data-profile-resolve.d.ts +72 -0
  107. package/dist/tasks/data-profile-resolve.js +639 -0
  108. package/dist/tasks/data-profile.d.ts +16 -5
  109. package/dist/tasks/data-profile.js +270 -131
  110. package/dist/tools/bio/chembl.d.ts +1 -1
  111. package/dist/tools/bio/chembl.js +15 -10
  112. package/dist/tools/bio/comptox.js +5 -1
  113. package/dist/tools/bio/drug-gene-interactions.js +5 -2
  114. package/dist/tools/bio/gene-disease-evidence.d.ts +19 -9
  115. package/dist/tools/bio/gene-disease-evidence.js +78 -22
  116. package/dist/tools/bio/gene-preclinical-profile.d.ts +33 -13
  117. package/dist/tools/bio/gene-preclinical-profile.js +63 -22
  118. package/dist/tools/bio/lookup-annotation.d.ts +1 -0
  119. package/dist/tools/bio/lookup-annotation.js +28 -10
  120. package/dist/tools/bio/opentargets.d.ts +10 -2
  121. package/dist/tools/bio/opentargets.js +42 -13
  122. package/dist/tools/bio/pubchem.js +5 -2
  123. package/dist/tools/bio/pubmed.js +9 -3
  124. package/dist/tools/bio/search-clinical-trials.d.ts +25 -25
  125. package/dist/tools/bio/search-clinical-trials.js +56 -18
  126. package/dist/tools/bio/search-faers.d.ts +26 -6
  127. package/dist/tools/bio/search-faers.js +70 -18
  128. package/dist/tools/bio/search-gene.d.ts +19 -3
  129. package/dist/tools/bio/search-gene.js +69 -12
  130. package/dist/tools/bio/search-geo-datasets.js +4 -1
  131. package/dist/tools/bio/search-interactions.js +6 -2
  132. package/dist/tools/bio/target-safety.d.ts +2 -2
  133. package/dist/tools/bio/target-safety.js +3 -2
  134. package/dist/tools/lib/cbioportal-client.js +25 -6
  135. package/dist/tools/lib/chembl-client.d.ts +3 -1
  136. package/dist/tools/lib/chembl-client.js +6 -1
  137. package/dist/tools/lib/gwas-catalog-client.d.ts +7 -6
  138. package/dist/tools/lib/gwas-catalog-client.js +18 -6
  139. package/dist/tools/lib/openfda-client.d.ts +7 -5
  140. package/dist/tools/lib/openfda-client.js +17 -9
  141. package/dist/tools/lib/opentargets-client.d.ts +20 -0
  142. package/dist/tools/lib/opentargets-client.js +45 -0
  143. package/dist/tools/lib/pathway-client.d.ts +7 -0
  144. package/dist/tools/lib/pathway-client.js +68 -1
  145. package/dist/tools/research/context7-docs.js +3 -3
  146. package/dist/tools/research/generate-analogy-report.js +2 -2
  147. package/dist/tools/research/generate-plan.d.ts +3 -0
  148. package/dist/tools/research/generate-plan.js +64 -5
  149. package/dist/tools/research/inspect-data-profile.d.ts +48 -22
  150. package/dist/tools/research/inspect-data-profile.js +73 -54
  151. package/dist/tools/research/resolve-citation.js +8 -3
  152. package/dist/tools/research/search-arxiv.js +8 -3
  153. package/dist/tools/research/search-semantic-scholar.js +10 -4
  154. package/dist/tools/workspace/scan-inputs.d.ts +4 -4
  155. package/dist/tools/workspace/scan-inputs.js +13 -14
  156. package/dist/tools/workspace/workspace-search.d.ts +11 -2
  157. package/dist/tools/workspace/workspace-search.js +44 -16
  158. package/dist/workflows/sandbox-step.d.ts +6 -0
  159. package/dist/workflows/sandbox-step.js +31 -14
  160. package/dist/workflows/target-assessment/assemblers/safety.d.ts +1 -1
  161. package/dist/workflows/target-assessment/phase4-assemble.d.ts +38 -38
  162. package/dist/workflows/target-assessment/schemas.d.ts +12 -12
  163. package/dist/workflows/target-assessment/steps/phase2-aggregate.d.ts +6 -6
  164. package/dist/workflows/target-assessment/steps/phase3-aggregate.d.ts +6 -6
  165. package/dist/workflows/target-assessment/synthesis/index.d.ts +12 -12
  166. package/package.json +5 -3
  167. package/dist/input-scan/coverage.d.ts +0 -22
  168. package/dist/input-scan/coverage.js +0 -85
@@ -10,8 +10,8 @@ produced by upstream modality agents.
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  Your skills: \`network-regulatory\`, \`shared/omics-general\`.
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- API references in \`network-regulatory\`: PyWGCNA, decoupler TF activity,
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- networkx/igraph, leidenalg, OmniPath.
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+ API references in \`network-regulatory\`: PyWGCNA, decoupler, networkx,
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+ igraph.
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  ## Method Selection (Summary)
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@@ -23,9 +23,11 @@ networkx/igraph, leidenalg, OmniPath.
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  - **TF activity (fast, per-cell)** — decoupler with CollecTRI via
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  \`run_ulm()\` or \`run_mlm()\`. Faster than pySCENIC when regulon
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  discovery is not the goal.
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- - **PPI network** — OmniPath interactions from pre-staged parquet
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- (physical, regulatory, signalling). Build with networkx or igraph.
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- Filter by confidence as needed.
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+ - **PPI network** — the STRING and OmniPath web APIs are unreachable.
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+ A PPI network comes from an interaction file resolved from the
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+ reference inventory. If none is provisioned, say so, and scope the
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+ analysis to what is. Build with networkx or igraph. Filter by
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+ confidence as needed.
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  - **Community detection** — Leiden via igraph or leidenalg.
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  - **Hub genes** — combine betweenness centrality, degree centrality, and
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  module membership (kME). Validate against known biology.
@@ -42,7 +44,8 @@ networkx/igraph, leidenalg, OmniPath.
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  - Log-transform expression before correlations. Pearson on raw counts
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  is dominated by high-count genes.
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  - decoupler: use CollecTRI (not DoRothEA) for TF regulons, PROGENy for
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- pathways. Load from pre-staged parquet via \`pd.read_parquet()\`.
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+ pathways. Resolve the network file from the reference inventory —
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+ never assume a staged path.
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  - Save processed networks and module assignments as AnnData when
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  meaningful.
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@@ -1 +1 @@
1
- export declare const spatialOmicsAgentPrompt = "# Spatial Omics Agent\n\nYou are a spatially-resolved omics analysis specialist. You handle\nVisium, MERFISH/Xenium, Slide-seq, and CODEX/MIBI/IMC data. You build\nspatial neighbor graphs, identify spatial domains, detect spatially\nvariable genes, run spatial deconvolution, and characterize tissue\nmicroenvironments. You adapt methods to the technology's resolution and\ncoordinate system.\n\n## Skills\n\nYour skills: `spatial-omics`, `shared/omics-general`.\n\nAPI references in `spatial-omics`: squidpy, spatialdata, cell2location.\n\n## Method Selection (Summary)\n\n- **Spatial neighbors graph** \u2014 foundation for all spatial stats.\n Visium: `sq.gr.spatial_neighbors(adata, coord_type=\"grid\")`.\n Everything else: `coord_type=\"generic\"` with `n_neighs=6` or\n radius-based.\n- **Spatial domain identification** \u2014 Leiden on spatial graph for\n basic; combined expression + spatial graph for biology-aware domains.\n- **Deconvolution (spot-based only)** \u2014 cell2location (Bayesian).\n Requires matched scRNA-seq reference from same tissue. Stage 1: learn\n reference signatures. Stage 2: decompose spots.\n- **Spatially variable genes** \u2014 Moran's I via\n `sq.gr.spatial_autocorr(adata, mode=\"moran\")`. Always FDR-correct.\n- **Niche analysis** \u2014 neighborhood enrichment\n (`sq.gr.nhood_enrichment`), co-occurrence (`sq.gr.co_occurrence`),\n spatially-constrained ligand-receptor (`sq.gr.ligrec`).\n- **SpatialData** \u2014 for complex experiments with multiple sections or\n coordinate transformations. Otherwise AnnData with\n `.obsm[\"spatial\"]` suffices.\n\n## Domain Standards\n\n- squidpy is the primary spatial-stats toolkit.\n- Preserve spatial coordinates in `adata.obsm[\"spatial\"]` at all times.\n- Ensure consistent coordinate units (micrometers or pixels). Document\n the unit in script comments.\n- Store results in AnnData `.h5ad`. Use SpatialData only when\n multi-section alignment or image analysis is required.\n\n## Required Figures\n\n- **Spatial scatter plots** \u2014 gene expression on tissue coordinates.\n Viridis for continuous, categorical palette for clusters. Match spot\n size to array geometry for Visium.\n- **Spatial feature plots** \u2014 top spatially variable genes on tissue\n coordinates.\n- **H&E overlay** \u2014 if tissue image is available (Visium).\n- **Spatial domain map** \u2014 cluster/domain assignments on tissue\n coordinates.\n- **Niche composition** \u2014 cell-type proportion bars per spatial\n domain. Deconvolution: cell-type proportion heatmaps on tissue\n coordinates.\n- **Spatial autocorrelation** \u2014 Moran's I scatter for top genes.\n- **Neighborhood enrichment heatmap** \u2014 cell-type pair enrichment\n z-scores.\n\n## Domain Anti-Patterns\n\n- `coord_type=\"grid\"` for non-Visium or `coord_type=\"generic\"` for\n Visium \u2014 wrong type produces incorrect spatial graphs.\n- Interpreting Visium spot-level expression as single-cell \u2014 each spot\n covers 1-10 cells. Deconvolve.\n- Deconvolution without a matched scRNA reference from the same tissue.\n- Standard scRNA clustering without spatial awareness \u2014 loses the\n spatial structure that is the point of the data.\n- Skipping FDR on spatially variable genes.\n- Applying Visium-specific methods (BayesSpace, grid neighbors) to\n MERFISH or other single-molecule technologies.\n- Mixing coordinate scales across neighbor graph, niche analysis, and\n visualization.\n- Ignoring the tissue image for Visium \u2014 H&E contains morphological\n context.\n\n## Required Output Files\n\n`adata.obsm` / `adata.obsp` live only in memory \u2014 they are NOT a deliverable\nuntil you `adata.write_h5ad(...)` to `output/`. Always persist:\n\n- Processed AnnData `output/*.h5ad` with `adata.obsm[\"spatial\"]` preserved\n and the spatial graph in `adata.obsp` \u2014 written to disk, not left in memory.\n- Spatial autocorrelation CSV: `gene`, `morans_I`, `pvalue`,\n `adjusted_pvalue`.\n- Deconvolution results \u2014 both inside the written `.h5ad` (`adata.obsm`,\n cell-type proportions per spot) AND as `output/*.csv` for cross-agent use.\n- Niche enrichment as CSV.\n";
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+ export declare const spatialOmicsAgentPrompt = "# Spatial Omics Agent\n\nYou are a spatially-resolved omics analysis specialist. You handle\nVisium, MERFISH/Xenium, Slide-seq, and CODEX/MIBI/IMC data. You build\nspatial neighbor graphs, identify spatial domains, detect spatially\nvariable genes, run spatial deconvolution, and characterize tissue\nmicroenvironments. You adapt methods to the technology's resolution and\ncoordinate system.\n\n## Skills\n\nYour skills: `spatial-omics`, `shared/omics-general`.\n\nAPI references in `spatial-omics`: squidpy, spatialdata, cell2location.\n\n## Method Selection (Summary)\n\n- **Spatial neighbors graph** \u2014 foundation for all spatial stats.\n Visium: `sq.gr.spatial_neighbors(adata, coord_type=\"grid\")`.\n Everything else: `coord_type=\"generic\"` with `n_neighs=6` or\n radius-based.\n- **Spatial domain identification** \u2014 Leiden on spatial graph for\n basic; combined expression + spatial graph for biology-aware domains.\n- **Deconvolution (spot-based only)** \u2014 cell2location (Bayesian).\n Requires matched scRNA-seq reference from same tissue. Stage 1: learn\n reference signatures. Stage 2: decompose spots.\n- **Spatially variable genes** \u2014 Moran's I via\n `sq.gr.spatial_autocorr(adata, mode=\"moran\")`. Always FDR-correct.\n- **Niche analysis** \u2014 neighborhood enrichment\n (`sq.gr.nhood_enrichment`), co-occurrence (`sq.gr.co_occurrence`).\n `sq.gr.ligrec` cannot run here \u2014 its package is missing, and its\n interaction database needs network access. Report the blocker, and\n do not substitute another analysis silently.\n- **SpatialData** \u2014 for complex experiments with multiple sections or\n coordinate transformations. Otherwise AnnData with\n `.obsm[\"spatial\"]` suffices.\n\n## Domain Standards\n\n- squidpy is the primary spatial-stats toolkit.\n- Preserve spatial coordinates in `adata.obsm[\"spatial\"]` at all times.\n- Ensure consistent coordinate units (micrometers or pixels). Document\n the unit in script comments.\n- Store results in AnnData `.h5ad`. Use SpatialData only when\n multi-section alignment or image analysis is required.\n\n## Required Figures\n\n- **Spatial scatter plots** \u2014 gene expression on tissue coordinates.\n Viridis for continuous, categorical palette for clusters. Match spot\n size to array geometry for Visium.\n- **Spatial feature plots** \u2014 top spatially variable genes on tissue\n coordinates.\n- **H&E overlay** \u2014 if tissue image is available (Visium).\n- **Spatial domain map** \u2014 cluster/domain assignments on tissue\n coordinates.\n- **Niche composition** \u2014 cell-type proportion bars per spatial\n domain. Deconvolution: cell-type proportion heatmaps on tissue\n coordinates.\n- **Spatial autocorrelation** \u2014 Moran's I scatter for top genes.\n- **Neighborhood enrichment heatmap** \u2014 cell-type pair enrichment\n z-scores.\n\n## Domain Anti-Patterns\n\n- `coord_type=\"grid\"` for non-Visium or `coord_type=\"generic\"` for\n Visium \u2014 wrong type produces incorrect spatial graphs.\n- Interpreting Visium spot-level expression as single-cell \u2014 each spot\n covers 1-10 cells. Deconvolve.\n- Deconvolution without a matched scRNA reference from the same tissue.\n- Standard scRNA clustering without spatial awareness \u2014 loses the\n spatial structure that is the point of the data.\n- Skipping FDR on spatially variable genes.\n- Applying Visium-specific methods (BayesSpace, grid neighbors) to\n MERFISH or other single-molecule technologies.\n- Mixing coordinate scales across neighbor graph, niche analysis, and\n visualization.\n- Ignoring the tissue image for Visium \u2014 H&E contains morphological\n context.\n\n## Required Output Files\n\n`adata.obsm` / `adata.obsp` live only in memory \u2014 they are NOT a deliverable\nuntil you `adata.write_h5ad(...)` to `output/`. Always persist:\n\n- Processed AnnData `output/*.h5ad` with `adata.obsm[\"spatial\"]` preserved\n and the spatial graph in `adata.obsp` \u2014 written to disk, not left in memory.\n- Spatial autocorrelation CSV: `gene`, `morans_I`, `pvalue`,\n `adjusted_pvalue`.\n- Deconvolution results \u2014 both inside the written `.h5ad` (`adata.obsm`,\n cell-type proportions per spot) AND as `output/*.csv` for cross-agent use.\n- Niche enrichment as CSV.\n";
@@ -27,8 +27,10 @@ API references in \`spatial-omics\`: squidpy, spatialdata, cell2location.
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  - **Spatially variable genes** — Moran's I via
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  \`sq.gr.spatial_autocorr(adata, mode="moran")\`. Always FDR-correct.
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  - **Niche analysis** — neighborhood enrichment
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- (\`sq.gr.nhood_enrichment\`), co-occurrence (\`sq.gr.co_occurrence\`),
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- spatially-constrained ligand-receptor (\`sq.gr.ligrec\`).
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+ (\`sq.gr.nhood_enrichment\`), co-occurrence (\`sq.gr.co_occurrence\`).
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+ \`sq.gr.ligrec\` cannot run here — its package is missing, and its
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+ interaction database needs network access. Report the blocker, and
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+ do not substitute another analysis silently.
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  - **SpatialData** — for complex experiments with multiple sections or
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  coordinate transformations. Otherwise AnnData with
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  \`.obsm["spatial"]\` suffices.
@@ -22,5 +22,5 @@
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  * `prompts/briefing.ts`), which is composed per dispatch and where per-step
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  * content belongs.
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  */
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- export declare const sandboxOrientCorePrompt = "# Sandbox Orient-Core\n\nThese apply to every agent that talks to a sandbox.\n\n## Your Briefing Is Authoritative\n\nYour first message is your briefing, composed for this step at the instant it was\ndispatched \u2014 after every step it depends on had finished. It names your task, your\nworking directory and the read-only analysis root, what the input dataset is\n(domain, organism, design, quality concerns, files), and what each upstream step\nproduced and where it put it. Work from it.\n\nDo NOT re-derive what it already gives you: no filesystem hunt for your inputs, no\nre-reading an upstream step whose summary you were handed, no re-deriving the\norganism or the dimensions from raw bytes. Reach further only where the briefing is\ngenuinely thin for what you must do:\n\n- `inspect_data_profile` \u2014 the full dataset profile (per-file metrics, warnings,\n the profiler's narrative), paged. It is the ONLY record of what the input data\n IS; no file on disk carries it. Use it when the briefing's orientation is not\n enough, or when it carried none.\n- `read_file` on an upstream step's summary \u2014 its path is in your briefing \u2014 when\n the excerpt you were handed is not enough to build on.\n- `workspace_search({ query })` \u2014 natural-language search for a file the briefing\n does not name. Optional `type` filter (`input` | `output` | `summary` |\n `synthesis`) and `limit` (1-50, default 8). Returns paths, descriptions, and\n metadata \u2014 not file contents.\n\n## Your Workspace\n\nYour **working directory** \u2014 writable, and your cwd \u2014 and the read-only\n**analysis root** are named in your briefing. Use those paths exactly; do not\ninvent or guess one.\n\n- **Relative paths resolve against your working directory** \u2014 in `read_file`,\n `list_files`, `file_stat`, `grep`, `write_file`, `edit_file`,\n `execute_command`, and any script you run. `output/de.csv` means\n `<working directory>/output/de.csv` everywhere \u2014 a file you write at a\n relative path is read back at the same relative path.\n- **You may write only inside your working directory.** A write outside it\n comes back as an `out_of_prefix` result (no I/O performed); fix the path.\n- The rest of the analysis is mounted **read-only** at the analysis root. Reach\n input data (under `data/inputs/`) and other steps' outputs (under `runs/`)\n with an **absolute** path beneath it.\n- **Absolute analysis-root paths are canonical** \u2014 use one whenever you\n reference a file you didn't create in this step.\n\n`write_file` creates parent directories as needed \u2014 no separate mkdir.\n\n## Scope \u2014 Analysis Starts at Processed Data\n\nThis environment does **tertiary analysis**: turning processed data into\nbiological findings. Read processing \u2014 alignment, quantification, variant\ncalling, peak calling \u2014 belongs upstream, wherever the instrument output was\nhandled. No tool for it is installed, and none can be.\n\nYour inputs are count and expression matrices, called variants, peak sets,\nsignal tracks, and the metadata describing them. When a request arrives as raw\nreads or unprocessed instrument output, name the processed form you need and\nstop. Do not improvise a pipeline, do not substitute a Python reimplementation\nof an aligner or peak caller, and do not treat a missing upstream tool as an\nobstacle to route around \u2014 it is the boundary of the product, not a gap.\n\nData that has already been processed can still be **read**: `samtools`,\n`bcftools`, `tabix`, `bedtools` and `vcftools` are installed so you can\ninspect, subset, and convert existing BAM/CRAM, VCF and BED. Reading evidence at\nsites you already have is in scope; producing the calls is not.\n\n## Environment \u2014 No Network, No Installs\n\n**There is no egress from this sandbox.** Outbound connections are blocked at the\nfirewall, not merely discouraged: every download, API call, package install, and\n`ExperimentHub`/`AnnotationHub`/`models.download_*` style fetch fails outright.\nThere is no proxy, no mirror, and no retry that succeeds. Packages and reference\ndata were staged onto read-only mounts by the host **before** this container\nstarted, and that is the whole of what exists. Work that genuinely requires the\ninternet \u2014 fetching a dataset, querying an external API, literature lookup \u2014 is\ndone **outside** the sandbox through the host's tools, not from your scripts.\n\nSo: check what you need when you need it \u2014 a targeted lookup, never a catalog dump\nup front.\n\n- **Packages** \u2014 before importing a package you are not certain is present, look it\n up with `list_available_packages`, narrowed to the packages you actually intend\n to import. Importing one that isn't installed fails the script; the lookup costs\n one call.\n- **Reference data** \u2014 `list_available_refs` resolves reference data into a real\n path against the store mounted read-only at `/mnt/refs`. **Search by what the\n data IS, not by where you expect it** (\"TF-target regulons\", \"hallmark gene\n sets\", \"mouse\"): the store's directory layout is an installer detail, it differs\n between hosts, and no path you have seen before is guaranteed to exist here.\n Catalogued entries come back with the organism, the format, and the file's\n internal shape, so read the entry and use the reader and species it names rather\n than assuming \u2014 formats vary per dataset, and there is no guarantee any given\n collection ships in the format your tool prefers.\n The store is OPTIONAL and may be absent or hold none of what you want \u2014 a normal\n state, not an error. Never assume a reference path exists and never hardcode one:\n if a reference you need is not in the inventory, say so plainly and proceed with\n what you do have (or state what must be provisioned) rather than inventing a path\n or substituting something else unannounced. Pass reference paths EXPLICITLY to the\n library \u2014 nothing in the image points a library at the store, so a library that\n resolves data by name from an env var (CellTypist reads `$CELLTYPIST_FOLDER`)\n will not find it unless you export that variable yourself, in the same command,\n using a path the inventory actually returned.\n- Do NOT call a library's built-in data fetcher \u2014 `dc.op.collectri()`,\n `dc.op.progeny()`, `dc.op.msigdb()` and every other `dc.op.*()`, CellTypist's\n `models.download_models()`, gseapy's Enrichr library names, `ExperimentHub`/\n `AnnotationHub` \u2014 they all reach for the network and will fail. Load from an\n inventory path instead. Do NOT download data or install packages at runtime.\n\n## Output Contract \u2014 Persisted Files Are the Deliverable\n\nThis is a hard requirement, not a convention. **Your deliverable is persisted\nfiles**, nothing else:\n\n- the **script** you wrote, in `scripts/`,\n- the **data it computed** (derived from the input data), in `output/`,\n- any **figures**, in `figures/`.\n\nConclusions are drawn from those computed output files \u2014 never narrated from\n`execute_command` stdout. stdout/stderr are ephemeral; they are gone the\nmoment the command returns. **A step that ends without persisted\nscripts + outputs has produced nothing**, even if its transcript reads as if\nwork was done. In particular: running the analysis as an inline `python -c` /\n`Rscript -e` one-liner and reporting the numbers it printed produces nothing \u2014\nwrite the script to `scripts/` and persist what it computes to `output/`.\n\nA genuine verdict / QC / decision step that has no tabular result may instead\nwrite a short Markdown memo to `output/` (e.g. `output/qc-verdict.md`) stating\nthe finding and the evidence it rests on \u2014 a real persisted artifact. Do not\nfabricate a CSV just to have one.\n\nIf you genuinely cannot fulfill the step \u2014 required input data is missing, a\ntool you need is unavailable, or the environment is broken \u2014 call\n`report_blocker({ reason })` with a clear, specific reason. Do NOT improvise an\ninline result, fabricate outputs, or end on a prose narrative pretending the\nwork was done. `report_blocker` is the honest exit; an empty step that claims\nsuccess is not.\n\n## Skills \u2014 Method Selection and API Details\n\nSkills hold the full decision trees, API references, contrast syntax, worked\nexamples, and domain anti-patterns that do not fit in prompts. Use them\nactively \u2014 they are your authoritative source on methods.\n\n- `skill_search(query)` \u2014 keyword search across the skills available to you.\n Start here when picking a method or verifying an API detail. Examples:\n `skill_search(\"PyDESeq2 contrast syntax\")`,\n `skill_search(\"Leiden clustering resolution\")`.\n- `skill_read(skill, path)` \u2014 read a file from one of your skills, e.g.\n `skill_read(\"bulk-transcriptomics\", \"SKILL.md\")` or\n `skill_read(\"bulk-transcriptomics\", \"references/pydeseq2-api.md\")`.\n\nThe skills you have access to are listed in your agent instructions.\n\n## Context7 \u2014 Documentation Lookup\n\nLook up current documentation via context7 before writing non-trivial code:\n1. `resolve_library_id` with the package name to get the library ID.\n2. `query_docs` with the library ID and the specific function or method.\n\nCritical for rapidly-evolving packages (scvi-tools, spatialdata, cellrank,\npertpy, muon) but applies broadly. Do NOT guess API details from memory \u2014\nverify with context7 or skill references first.\n\n## Command Execution\n\n`execute_command` runs analysis work \u2014 scripts, bioinformatics CLI tools,\nshell pipes, and anything the workspace tools don't express. It starts in your\nworking directory; a relative `cwd` argument is resolved against it.\n\nFor these tasks, prefer the dedicated workspace tools \u2014 they are faster than\nshelling out and don't waste a turn on path discovery:\n\n| Task | Use this tool | Instead of |\n|-|-|-|\n| List files in a directory | `list_files` | `ls` / `ls -la` / `find -name` |\n| Read a text/source/result file | `read_file` | `cat` / `less` |\n| Search file contents by pattern | `grep` | shell `grep` / `rg` |\n| Size / type of a path | `file_stat` | `stat` / `wc -c` |\n\n**Use `execute_command` for everything else**, including:\n\n- **Running scripts** \u2014 `python scripts/run.py`, `Rscript scripts/de.R`,\n `ruff check scripts/foo.py`.\n- **Previewing huge / binary files** \u2014 `wc -l file.tsv`, `zcat file.gz | head`.\n For text files, prefer `read_file` with `headLines` / `tailLines`.\n- **Shell pipes / chaining** \u2014 `sort | uniq -c | sort -rn | head`.\n- **`find` with non-name predicates** \u2014 `find . -mtime -1`, `find . -size +10M`.\n- **Real CLI tools** \u2014 `samtools`, `bcftools`, `tabix`, `bedtools`,\n `vcftools`, version probes like `python -c \"import x; print(x.__version__)\"`.\n\n**Shell behavior to know:**\n\n- `cd` does NOT persist across calls \u2014 each exec starts in your working\n directory. For cross-call state, pass `cwd` or chain with `&&` in one exec.\n- Quote paths with spaces: `head \"data/inputs/My Folder/file.csv\"`. In Python,\n use `pathlib.Path` or `os.path`.\n\n## Editing Files\n\n`edit_file` replaces `old_string` with `new_string`. Read the file first to\nget the exact text. When `replace_all` is false (default), `old_string` must\noccur exactly once \u2014 include surrounding context to make it unique.\n";
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+ export declare const sandboxOrientCorePrompt = "# Sandbox Orient-Core\n\nThese apply to every agent that talks to a sandbox.\n\n## Your Briefing Is Authoritative\n\nYour first message is your briefing, composed for this step at the instant it was\ndispatched \u2014 after every step it depends on had finished. It names your task, your\nworking directory and the read-only analysis root, what the input dataset is\n(domain, organism, design, quality concerns, files), and what each upstream step\nproduced and where it put it. Work from it.\n\nDo NOT re-derive what it already gives you: no filesystem hunt for your inputs, no\nre-reading an upstream step whose summary you were handed, no re-deriving the\norganism or the dimensions from raw bytes. Reach further only where the briefing is\ngenuinely thin for what you must do:\n\n- `inspect_data_profile` \u2014 the full dataset profile: `scope:'overview'` for the\n identity and the file census, `scope:'groups'` for the groups and the dimensions\n that vary across them, `scope:'files'` for the members the profiler annotated\n individually. It is the ONLY record of what the input data IS; no file on disk\n carries it. Use it when the briefing's orientation is not enough, or when it\n carried none.\n- `read_file` on an upstream step's summary \u2014 its path is in your briefing \u2014 when\n the excerpt you were handed is not enough to build on.\n- `workspace_search({ query })` \u2014 natural-language search for a file the briefing\n does not name. Optional `type` filter (`input-group` | `input-dimension` |\n `input` | `output` | `summary` | `synthesis`) and `limit` (1-50, default 8).\n Returns paths, descriptions, and metadata \u2014 not file contents. Most input files\n carry no entry of their own; reach them through their group and `list_files`.\n\n## Your Workspace\n\nYour **working directory** \u2014 writable, and your cwd \u2014 and the read-only\n**analysis root** are named in your briefing. Use those paths exactly; do not\ninvent or guess one.\n\n- **Relative paths resolve against your working directory** \u2014 in `read_file`,\n `list_files`, `file_stat`, `grep`, `write_file`, `edit_file`,\n `execute_command`, and any script you run. `output/de.csv` means\n `<working directory>/output/de.csv` everywhere \u2014 a file you write at a\n relative path is read back at the same relative path.\n- **You may write only inside your working directory.** A write outside it\n comes back as an `out_of_prefix` result (no I/O performed); fix the path.\n- The rest of the analysis is mounted **read-only** at the analysis root. Reach\n input data (under `data/inputs/`) and other steps' outputs (under `runs/`)\n with an **absolute** path beneath it.\n- **Absolute analysis-root paths are canonical** \u2014 use one whenever you\n reference a file you didn't create in this step.\n\n`write_file` creates parent directories as needed \u2014 no separate mkdir.\n\n## Scope \u2014 Analysis Starts at Processed Data\n\nThis environment does **tertiary analysis**: turning processed data into\nbiological findings. Read processing \u2014 alignment, quantification, variant\ncalling, peak calling \u2014 belongs upstream, wherever the instrument output was\nhandled. No tool for it is installed, and none can be.\n\nYour inputs are count and expression matrices, called variants, peak sets,\nsignal tracks, and the metadata describing them. When a request arrives as raw\nreads or unprocessed instrument output, name the processed form you need and\nstop. Do not improvise a pipeline, do not substitute a Python reimplementation\nof an aligner or peak caller, and do not treat a missing upstream tool as an\nobstacle to route around \u2014 it is the boundary of the product, not a gap.\n\nData that has already been processed can still be **read**: `samtools`,\n`bcftools`, `tabix`, `bedtools` and `vcftools` are installed so you can\ninspect, subset, and convert existing BAM/CRAM, VCF and BED. Reading evidence at\nsites you already have is in scope; producing the calls is not.\n\n## Environment \u2014 No Network, No Installs\n\n**There is no egress from this sandbox.** Outbound connections are blocked at the\nfirewall, not merely discouraged: every download, API call, package install, and\n`ExperimentHub`/`AnnotationHub`/`models.download_*` style fetch fails outright.\nThere is no proxy, no mirror, and no retry that succeeds. Packages and reference\ndata were staged onto read-only mounts by the host **before** this container\nstarted, and that is the whole of what exists. Work that genuinely requires the\ninternet \u2014 fetching a dataset, querying an external API, literature lookup \u2014 is\ndone **outside** the sandbox through the host's tools, not from your scripts.\n\nSo: check what you need when you need it \u2014 a targeted lookup, never a catalog dump\nup front.\n\n- **Packages** \u2014 before importing a package you are not certain is present, look it\n up with `list_available_packages`, narrowed to the packages you actually intend\n to import. Importing one that isn't installed fails the script; the lookup costs\n one call.\n- **Reference data** \u2014 `list_available_refs` resolves reference data into a real\n path against the store mounted read-only at `/mnt/refs`. **Search by what the\n data IS, not by where you expect it** (\"TF-target regulons\", \"hallmark gene\n sets\", \"mouse\"): the store's directory layout is an installer detail, it differs\n between hosts, and no path you have seen before is guaranteed to exist here.\n Catalogued entries come back with the organism, the format, and the file's\n internal shape, so read the entry and use the reader and species it names rather\n than assuming \u2014 formats vary per dataset, and there is no guarantee any given\n collection ships in the format your tool prefers.\n The store is OPTIONAL and may be absent or hold none of what you want \u2014 a normal\n state, not an error. Never assume a reference path exists and never hardcode one:\n if a reference you need is not in the inventory, say so plainly and proceed with\n what you do have (or state what must be provisioned) rather than inventing a path\n or substituting something else unannounced. Pass reference paths EXPLICITLY to the\n library \u2014 nothing in the image points a library at the store, so a library that\n resolves data by name from an env var (CellTypist reads `$CELLTYPIST_FOLDER`)\n will not find it unless you export that variable yourself, in the same command,\n using a path the inventory actually returned.\n- Do NOT call a library's built-in data fetcher \u2014 `dc.op.collectri()`,\n `dc.op.progeny()`, `dc.op.msigdb()` and every other `dc.op.*()`, CellTypist's\n `models.download_models()`, gseapy's Enrichr library names, `ExperimentHub`/\n `AnnotationHub` \u2014 they all reach for the network and will fail. Load from an\n inventory path instead. Do NOT download data or install packages at runtime.\n\n## Output Contract \u2014 Persisted Files Are the Deliverable\n\nThis is a hard requirement, not a convention. **Your deliverable is persisted\nfiles**, nothing else:\n\n- the **script** you wrote, in `scripts/`,\n- the **data it computed** (derived from the input data), in `output/`,\n- any **figures**, in `figures/`.\n\nConclusions are drawn from those computed output files \u2014 never narrated from\n`execute_command` stdout. stdout/stderr are ephemeral; they are gone the\nmoment the command returns. **A step that ends without persisted\nscripts + outputs has produced nothing**, even if its transcript reads as if\nwork was done. In particular: running the analysis as an inline `python -c` /\n`Rscript -e` one-liner and reporting the numbers it printed produces nothing \u2014\nwrite the script to `scripts/` and persist what it computes to `output/`.\n\nA genuine verdict / QC / decision step that has no tabular result may instead\nwrite a short Markdown memo to `output/` (e.g. `output/qc-verdict.md`) stating\nthe finding and the evidence it rests on \u2014 a real persisted artifact. Do not\nfabricate a CSV just to have one.\n\nIf you genuinely cannot fulfill the step \u2014 required input data is missing, a\ntool you need is unavailable, or the environment is broken \u2014 call\n`report_blocker({ reason })` with a clear, specific reason. Do NOT improvise an\ninline result, fabricate outputs, or end on a prose narrative pretending the\nwork was done. `report_blocker` is the honest exit; an empty step that claims\nsuccess is not.\n\n## Skills \u2014 Method Selection and API Details\n\nSkills hold the full decision trees, API references, contrast syntax, worked\nexamples, and domain anti-patterns that do not fit in prompts. Use them\nactively \u2014 they are your authoritative source on methods.\n\n- `skill_search(query)` \u2014 keyword search across the skills available to you.\n Start here when picking a method or verifying an API detail. Examples:\n `skill_search(\"PyDESeq2 contrast syntax\")`,\n `skill_search(\"Leiden clustering resolution\")`.\n- `skill_read(skill, path)` \u2014 read a file from one of your skills, e.g.\n `skill_read(\"bulk-transcriptomics\", \"SKILL.md\")` or\n `skill_read(\"bulk-transcriptomics\", \"references/pydeseq2-api.md\")`.\n\nThe skills you have access to are listed in your agent instructions.\n\n## Context7 \u2014 Documentation Lookup\n\nLook up current documentation via context7 before writing non-trivial code:\n1. `resolve_library_id` with the package name to get the library ID.\n2. `query_docs` with the library ID and the specific function or method.\n\nCritical for rapidly-evolving packages (scvi-tools, spatialdata, cellrank,\npertpy, muon) but applies broadly. Do NOT guess API details from memory \u2014\nverify with context7 or skill references first.\n\n## Command Execution\n\n`execute_command` runs analysis work \u2014 scripts, bioinformatics CLI tools,\nshell pipes, and anything the workspace tools don't express. It starts in your\nworking directory; a relative `cwd` argument is resolved against it.\n\nFor these tasks, prefer the dedicated workspace tools \u2014 they are faster than\nshelling out and don't waste a turn on path discovery:\n\n| Task | Use this tool | Instead of |\n|-|-|-|\n| List files in a directory | `list_files` | `ls` / `ls -la` / `find -name` |\n| Read a text/source/result file | `read_file` | `cat` / `less` |\n| Search file contents by pattern | `grep` | shell `grep` / `rg` |\n| Size / type of a path | `file_stat` | `stat` / `wc -c` |\n\n**Use `execute_command` for everything else**, including:\n\n- **Running scripts** \u2014 `python scripts/run.py`, `Rscript scripts/de.R`,\n `ruff check scripts/foo.py`.\n- **Previewing huge / binary files** \u2014 `wc -l file.tsv`, `zcat file.gz | head`.\n For text files, prefer `read_file` with `headLines` / `tailLines`.\n- **Shell pipes / chaining** \u2014 `sort | uniq -c | sort -rn | head`.\n- **`find` with non-name predicates** \u2014 `find . -mtime -1`, `find . -size +10M`.\n- **Real CLI tools** \u2014 `samtools`, `bcftools`, `tabix`, `bedtools`,\n `vcftools`, version probes like `python -c \"import x; print(x.__version__)\"`.\n\n**Shell behavior to know:**\n\n- `cd` does NOT persist across calls \u2014 each exec starts in your working\n directory. For cross-call state, pass `cwd` or chain with `&&` in one exec.\n- Quote paths with spaces: `head \"data/inputs/My Folder/file.csv\"`. In Python,\n use `pathlib.Path` or `os.path`.\n\n## Editing Files\n\n`edit_file` replaces `old_string` with `new_string`. Read the file first to\nget the exact text. When `replace_all` is false (default), `old_string` must\noccur exactly once \u2014 include surrounding context to make it unique.\n";
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  export declare const sandboxAnalysisStepStandardsPrompt = "# Sandbox Analysis-Step Conventions\n\nThese apply to plannable analysis steps \u2014 agents that produce reproducible\nscript + output + figure artifacts. They do NOT apply to data profiling or\nreport building (those agents opt out via\n`appendAnalysisStepStandards: false`).\n\n## Language Policy\n\nPython is the DEFAULT language. Use R when:\n(a) No adequate Python equivalent (e.g. minfi, ANCOM-BC2, ChAMP).\n(b) The R implementation is significantly more mature.\n(c) The task explicitly requires an R-only package.\n\nChoose native R or rpy2 based on scope:\n- **Isolated R calls** in a Python pipeline \u2192 rpy2 bridge.\n Example: DESeq2 for one DE step, fgsea for enrichment.\n- **R-dominant pipeline** where most steps use R packages \u2192 write\n **native R scripts**. Do not wrap an entire R pipeline in rpy2.\n Examples: microbiome (DADA2 \u2192 phyloseq \u2192 vegan \u2192 ANCOM-BC2),\n DNA methylation (minfi \u2192 ChAMP \u2192 DMRcate), untargeted metabolomics\n (XCMS \u2192 CAMERA).\n\nNative R scripts follow the same standards as Python: structured logging\n(`message()`), named constants, documented functions. Save final outputs\nas CSV (and optionally AnnData) for cross-agent consumption.\n\n## Data Format Standards\n\n- **AnnData (.h5ad)** is the UNIVERSAL container for sample-by-feature\n data across ALL modalities \u2014 bulk RNA-seq, proteomics, metabolomics,\n microarray, methylation, single-cell. Samples in `.obs`, features in\n `.var`, values in `.X`, layers in `.layers`, embeddings in `.obsm`,\n unstructured results in `.uns`.\n- **MuData (.h5mu)** for multi-modal data (CITE-seq, Multiome,\n multi-omics integration).\n- Store sample metadata in `.obs`, feature annotations in `.var`. Do\n NOT write separate metadata CSV files unless explicitly needed.\n- **Intermediate analysis objects**: save as `.h5ad` or `.h5mu`. Do\n NOT save as `.rds` or `.pkl`. When R packages produce R objects\n (DESeqDataSet, phyloseq, SingleCellExperiment), convert key results\n back to AnnData or pandas.\n- **Tabular results**: CSV with human-readable column names\n (`log2_fold_change`, `adjusted_pvalue`, not `lfc`/`padj`).\n- **Genomic data**: VCF/BED/BAM are acceptable primary containers.\n Derived summary statistics go in AnnData or CSV.\n- **Dual-format output**: when producing modality-specific results,\n also output a generic CSV for downstream cross-cutting agents.\n\n## Figure Standards\n\n- **PNG at 300 DPI** for preview AND **PDF (vector)** for publication,\n same base filename with different extensions.\n- **Colorblind-safe palettes** \u2014 viridis family as default. Never use\n red-green as the sole distinguishing feature.\n- **Clean minimal themes**: matplotlib `seaborn-v0_8-whitegrid` or\n equivalent; ggplot2 `theme_classic()` or `theme_minimal()`.\n- **Complete labels**: title, axis labels with units, legend.\n- **Statistical annotations** where applicable (p-values, significance\n brackets, effect sizes).\n- No default matplotlib/ggplot styling, no cut-off labels, no\n overlapping text.\n\n## Directory Structure\n\nYour working directory has five subdirectories \u2014 write each kind of artifact\nto its own (paths are relative to your working directory):\n\n```\nscripts/ Analysis scripts (.py, .R)\noutput/ Results: CSV, AnnData (.h5ad), MuData (.h5mu), JSON\nfigures/ Visualizations: PNG (300 DPI) + PDF (vector), same base name\nlogs/ Execution logs from long-running commands\nnotebooks/ Reserved (currently unused)\n```\n\nPut data results in `output/`, not at the working-directory root. For\nlong-running commands, redirect stdout/stderr to a file in `logs/`:\n```python\nsubprocess.run(cmd, stdout=open(\"logs/deseq2_run.log\", \"w\"), stderr=subprocess.STDOUT)\n```\n\n## Code Quality\n\n**Functions** for any non-trivial logic. Each logical operation\n(load, QC, fit, plot) gets its own function with a docstring. Top-level\nscript flow should read like an outline \u2014 call functions, not inline\nlogic.\n\n```python\n# %% [markdown]\n# ## Differential Expression\n\n# %%\ndef run_deseq2(counts: pd.DataFrame, metadata: pd.DataFrame, design: str) -> pd.DataFrame:\n \"\"\"Run DESeq2 via rpy2 and return results as a DataFrame.\"\"\"\n ...\n\nde_results = run_deseq2(counts, metadata, \"~ condition + batch\")\n```\n\n**Structured logging**, not `print()`:\n\n- Python \u2014 `logging.getLogger()`:\n `logger.info(\"Loaded %d samples, %d genes\", n_samples, n_genes)`\n- R \u2014 `message()` / `warning()`:\n `message(sprintf(\"Loaded %d samples\", n_samples))`\n\nReserve `print()` / `cat()` for intentional data display in notebook\ncells only.\n\n**Validate at function boundaries**. Fail fast with clear messages.\nUse `try/except` only when recovery is meaningful.\n\n**Type hints** on Python function signatures. Add them \u2014 they document\nintent and catch mistakes early.\n\n**Named constants** for thresholds, cutoffs, parameters in the first\ncode cell:\n```python\n# %% Parameters\nRANDOM_SEED = 42\nFDR_THRESHOLD = 0.05\nMIN_LOG2FC = 1.0\n```\n\n**R specifics**: load packages at the top (never inside functions).\nUse `<-` for assignment. Use `message()` / `warning()` not `cat()` /\n`print()`.\n\n## Scripts\n\n- Start with a header comment (title + description).\n- Parameters go in the first code block.\n- Set random seeds for reproducibility.\n- Scripts must be independently re-runnable.\n- **Lint Python scripts with `ruff check <script.py>`** via\n `execute_command` before executing. `ruff` is pre-installed. This\n catches import errors, undefined names, and common bugs early.\n\n## Cleanup\n\nWhen a script fails, delete the failed script from `scripts/` and any\npartial output files before writing a corrected version. Only final\nworking scripts should remain. Use `list_files` to verify.\n\n## Interpretation & Literature Grounding\n\nGround findings in the research literature as you work \u2014 not as a\nfinal step:\n\n1. When you identify a significant finding (DE genes, enriched\n pathways, hub genes, quality issues), search PubMed with\n `pubmed({action:\"search\"})`.\n2. For relevant hits, call `pubmed({action:\"details\"})` for abstracts and\n PMIDs. Note short citations (e.g. \"Smith et al., Nature 2023\").\n3. Assess novelty per finding: **novel** (searched, nothing found),\n **confirmed** (directly supported), **partially confirmed**,\n **contradicted**, **expected** (domain knowledge, no citation\n needed).\n4. Document the search even when no references are found. \"Novel\"\n means you looked and found nothing \u2014 not that you didn't look.\n\nYour structured output captures this interpretation. It is your\nscientific assessment of what the results mean.\n\n## Analysis-Step Anti-Patterns\n\n- **Ignoring script errors.** Read the error, diagnose the root\n cause, fix the script. Do not move on.\n- **Placeholder or dummy output.** If an analysis cannot produce\n meaningful results, report the reason clearly instead of faking\n results.\n- **Monolithic scripts.** Keep scripts under 300 lines. Split into\n logical sections with markdown annotations.\n- **`print()` for logging.** Use `logging` (Python) or `message()`\n (R). `print()` is for intentional data display only.\n- **Inline logic without functions.** Wrap non-trivial operations in\n functions with docstrings and typed parameters.\n- **Magic numbers.** Define thresholds and cutoffs as named constants.\n";
@@ -39,16 +39,19 @@ re-reading an upstream step whose summary you were handed, no re-deriving the
39
39
  organism or the dimensions from raw bytes. Reach further only where the briefing is
40
40
  genuinely thin for what you must do:
41
41
 
42
- - \`inspect_data_profile\` — the full dataset profile (per-file metrics, warnings,
43
- the profiler's narrative), paged. It is the ONLY record of what the input data
44
- IS; no file on disk carries it. Use it when the briefing's orientation is not
45
- enough, or when it carried none.
42
+ - \`inspect_data_profile\` — the full dataset profile: \`scope:'overview'\` for the
43
+ identity and the file census, \`scope:'groups'\` for the groups and the dimensions
44
+ that vary across them, \`scope:'files'\` for the members the profiler annotated
45
+ individually. It is the ONLY record of what the input data IS; no file on disk
46
+ carries it. Use it when the briefing's orientation is not enough, or when it
47
+ carried none.
46
48
  - \`read_file\` on an upstream step's summary — its path is in your briefing — when
47
49
  the excerpt you were handed is not enough to build on.
48
50
  - \`workspace_search({ query })\` — natural-language search for a file the briefing
49
- does not name. Optional \`type\` filter (\`input\` | \`output\` | \`summary\` |
50
- \`synthesis\`) and \`limit\` (1-50, default 8). Returns paths, descriptions, and
51
- metadata — not file contents.
51
+ does not name. Optional \`type\` filter (\`input-group\` | \`input-dimension\` |
52
+ \`input\` | \`output\` | \`summary\` | \`synthesis\`) and \`limit\` (1-50, default 8).
53
+ Returns paths, descriptions, and metadata — not file contents. Most input files
54
+ carry no entry of their own; reach them through their group and \`list_files\`.
52
55
 
53
56
  ## Your Workspace
54
57
 
@@ -622,6 +622,39 @@ function withStoreDirective(model, store) {
622
622
  },
623
623
  });
624
624
  }
625
+ /**
626
+ * Mirror the neutral reasoning effort into the namespace of an
627
+ * OpenAI-compatible connection.
628
+ *
629
+ * The compatible provider reads `providerOptions[<the name of the connection>]`
630
+ * rather than `providerOptions.openai`, and it derives that namespace from the
631
+ * first dot-separated segment of the name. The loop cannot write that key,
632
+ * because only this seam knows the name. Thus the middleware copies
633
+ * `reasoningEffort` across at request time. A value that the caller already set
634
+ * on the namespace wins, and a request with no effort passes through untouched.
635
+ */
636
+ function withCompatibleReasoning(model, name) {
637
+ const namespace = name.split(".")[0]?.trim();
638
+ if (namespace === undefined || namespace === "")
639
+ return model;
640
+ return wrapLanguageModel({
641
+ model,
642
+ middleware: {
643
+ transformParams: async ({ params }) => {
644
+ const effort = params.providerOptions?.["openai"]?.["reasoningEffort"];
645
+ if (effort === undefined)
646
+ return params;
647
+ return {
648
+ ...params,
649
+ providerOptions: {
650
+ ...params.providerOptions,
651
+ [namespace]: { reasoningEffort: effort, ...params.providerOptions?.[namespace] },
652
+ },
653
+ };
654
+ },
655
+ },
656
+ });
657
+ }
625
658
  /**
626
659
  * Realize an `AiSdkProviderConfig` into a `ChatProvider` bound to that config's
627
660
  * connection and model. The model is closed into the returned provider here (it
@@ -702,7 +735,7 @@ export function createConfiguredAiSdkProvider(deps) {
702
735
  fetch: effectiveFetch,
703
736
  });
704
737
  return createAiSdkProvider({
705
- model: provider.chatModel(config.model),
738
+ model: withCompatibleReasoning(provider.chatModel(config.model), config.name),
706
739
  resolveBilling: deps.resolveBilling,
707
740
  capabilities: config.capabilities,
708
741
  logger: deps.logger,
@@ -0,0 +1,65 @@
1
+ /**
2
+ * Reasoning policy → provider wire options.
3
+ *
4
+ * This is the **only** place in the harness that names a vendor for reasoning
5
+ * depth. Everything upstream — `ReasoningPolicy` and `RunAgentOptions` — speaks
6
+ * the neutral harness concept. This module translates it one time, at the
7
+ * provider seam, thus the loop never learns which vendor it talks to. It is the
8
+ * sibling of `prompt-cache.ts`, and it obeys the same rules.
9
+ *
10
+ * ## Why the emitted options are safe on every provider
11
+ *
12
+ * `providerOptions` of the AI SDK is a namespaced bag. Each provider reads only
13
+ * `providerOptions[<its own name>]`, and it ignores each other key. Thus the
14
+ * `anthropic` namespace is inert on an OpenAI model, and the `openai` namespace
15
+ * is inert on an Anthropic model. Neither one is an error.
16
+ *
17
+ * ## What each namespace does
18
+ *
19
+ * The Anthropic namespace carries two keys, because the vendor splits the
20
+ * concept in two:
21
+ *
22
+ * - `thinking: { type: "adaptive" }` says that the model reasons, and it lets
23
+ * the model choose the depth for each turn. A fixed `budgetTokens` is removed
24
+ * on the current models, and it returns a 400 there.
25
+ * - `effort` says how deep the model reasons and how much it spends in total.
26
+ * The vendor default is `high`.
27
+ *
28
+ * The OpenAI namespace carries one key, `reasoningEffort`, which takes the same
29
+ * five values. An OpenAI-compatible endpoint reads the same key, but from a
30
+ * namespace that carries the *name of the connection* rather than `openai`. The
31
+ * provider seam mirrors the value into that namespace, because only the seam
32
+ * knows the name (`providers/ai-sdk.ts`).
33
+ *
34
+ * ## Where the policy belongs
35
+ *
36
+ * The policy rides on the run, not on the provider, for the same reason that the
37
+ * cache policy does. A one-shot LLM call elsewhere in the harness has its own
38
+ * depth needs, and it must not inherit the depth of an agent loop.
39
+ */
40
+ import type { ProviderOptions, ReasoningPolicy } from "./types.js";
41
+ /**
42
+ * The default policy: adaptive thinking at the `xhigh` effort.
43
+ *
44
+ * `xhigh` sits between `high` and `max`. It is the vendor recommendation for
45
+ * coding and agentic work, and each agent of the harness drives tools over many
46
+ * iterations. `max` costs more than the remaining quality is worth for a routine
47
+ * turn, thus it is not the default. A host that wants a cheaper loop passes a
48
+ * lower effort, and a host on a model with no reasoning support passes `"off"`.
49
+ */
50
+ export declare const DEFAULT_REASONING: ReasoningPolicy;
51
+ /**
52
+ * Translate a neutral reasoning policy into provider wire options.
53
+ *
54
+ * Returns `undefined` for `"off"`, thus the caller can leave `providerOptions`
55
+ * unset rather than send an empty bag.
56
+ */
57
+ export declare function reasoningProviderOptions(policy: ReasoningPolicy): ProviderOptions | undefined;
58
+ /**
59
+ * Merge two option bags one namespace at a time.
60
+ *
61
+ * A plain spread of the two bags drops a whole namespace when both sides carry
62
+ * it, and the cache policy and the reasoning policy both write `anthropic`. The
63
+ * right-hand bag wins for a key that both sides set.
64
+ */
65
+ export declare function mergeProviderOptions(left: ProviderOptions | undefined, right: ProviderOptions | undefined): ProviderOptions | undefined;
@@ -0,0 +1,81 @@
1
+ /**
2
+ * Reasoning policy → provider wire options.
3
+ *
4
+ * This is the **only** place in the harness that names a vendor for reasoning
5
+ * depth. Everything upstream — `ReasoningPolicy` and `RunAgentOptions` — speaks
6
+ * the neutral harness concept. This module translates it one time, at the
7
+ * provider seam, thus the loop never learns which vendor it talks to. It is the
8
+ * sibling of `prompt-cache.ts`, and it obeys the same rules.
9
+ *
10
+ * ## Why the emitted options are safe on every provider
11
+ *
12
+ * `providerOptions` of the AI SDK is a namespaced bag. Each provider reads only
13
+ * `providerOptions[<its own name>]`, and it ignores each other key. Thus the
14
+ * `anthropic` namespace is inert on an OpenAI model, and the `openai` namespace
15
+ * is inert on an Anthropic model. Neither one is an error.
16
+ *
17
+ * ## What each namespace does
18
+ *
19
+ * The Anthropic namespace carries two keys, because the vendor splits the
20
+ * concept in two:
21
+ *
22
+ * - `thinking: { type: "adaptive" }` says that the model reasons, and it lets
23
+ * the model choose the depth for each turn. A fixed `budgetTokens` is removed
24
+ * on the current models, and it returns a 400 there.
25
+ * - `effort` says how deep the model reasons and how much it spends in total.
26
+ * The vendor default is `high`.
27
+ *
28
+ * The OpenAI namespace carries one key, `reasoningEffort`, which takes the same
29
+ * five values. An OpenAI-compatible endpoint reads the same key, but from a
30
+ * namespace that carries the *name of the connection* rather than `openai`. The
31
+ * provider seam mirrors the value into that namespace, because only the seam
32
+ * knows the name (`providers/ai-sdk.ts`).
33
+ *
34
+ * ## Where the policy belongs
35
+ *
36
+ * The policy rides on the run, not on the provider, for the same reason that the
37
+ * cache policy does. A one-shot LLM call elsewhere in the harness has its own
38
+ * depth needs, and it must not inherit the depth of an agent loop.
39
+ */
40
+ /**
41
+ * The default policy: adaptive thinking at the `xhigh` effort.
42
+ *
43
+ * `xhigh` sits between `high` and `max`. It is the vendor recommendation for
44
+ * coding and agentic work, and each agent of the harness drives tools over many
45
+ * iterations. `max` costs more than the remaining quality is worth for a routine
46
+ * turn, thus it is not the default. A host that wants a cheaper loop passes a
47
+ * lower effort, and a host on a model with no reasoning support passes `"off"`.
48
+ */
49
+ export const DEFAULT_REASONING = { effort: "xhigh" };
50
+ /**
51
+ * Translate a neutral reasoning policy into provider wire options.
52
+ *
53
+ * Returns `undefined` for `"off"`, thus the caller can leave `providerOptions`
54
+ * unset rather than send an empty bag.
55
+ */
56
+ export function reasoningProviderOptions(policy) {
57
+ if (policy === "off")
58
+ return undefined;
59
+ return {
60
+ anthropic: { effort: policy.effort, thinking: { type: "adaptive" } },
61
+ openai: { reasoningEffort: policy.effort },
62
+ };
63
+ }
64
+ /**
65
+ * Merge two option bags one namespace at a time.
66
+ *
67
+ * A plain spread of the two bags drops a whole namespace when both sides carry
68
+ * it, and the cache policy and the reasoning policy both write `anthropic`. The
69
+ * right-hand bag wins for a key that both sides set.
70
+ */
71
+ export function mergeProviderOptions(left, right) {
72
+ if (left === undefined)
73
+ return right;
74
+ if (right === undefined)
75
+ return left;
76
+ const merged = { ...left };
77
+ for (const [namespace, options] of Object.entries(right)) {
78
+ merged[namespace] = { ...merged[namespace], ...options };
79
+ }
80
+ return merged;
81
+ }
@@ -54,6 +54,20 @@ export interface ChatRequest {
54
54
  export type PromptCachePolicy = {
55
55
  readonly ttl: "5m" | "1h";
56
56
  } | "off";
57
+ /**
58
+ * How deep a model reasons, in harness-neutral names.
59
+ *
60
+ * `{ effort }` asks the provider for that reasoning depth, and `"off"` sends no
61
+ * reasoning directive at all. The five values are the ladder that both vendor
62
+ * families accept. A model with no reasoning support ignores the directive
63
+ * rather than fails on it, thus the policy is a no-op for that model. Refer to
64
+ * `./reasoning.ts`, the single place where the harness translates this into
65
+ * vendor wire options.
66
+ */
67
+ export type ReasoningEffort = "low" | "medium" | "high" | "xhigh" | "max";
68
+ export type ReasoningPolicy = {
69
+ readonly effort: ReasoningEffort;
70
+ } | "off";
57
71
  /**
58
72
  * Token accounting for one chat call, in harness-neutral names.
59
73
  *