@inflexa-ai/harness 0.17.0 → 0.19.0

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Files changed (249) hide show
  1. package/dist/agents/report-builder.d.ts +2 -0
  2. package/dist/agents/report-builder.js +2 -0
  3. package/dist/agents/report-session-agent.d.ts +56 -0
  4. package/dist/agents/report-session-agent.js +72 -0
  5. package/dist/app/report-session-runtime.d.ts +72 -0
  6. package/dist/app/report-session-runtime.js +157 -0
  7. package/dist/app/spawn-report-session.d.ts +85 -0
  8. package/dist/app/spawn-report-session.js +83 -0
  9. package/dist/contracts/chat-events.d.ts +9 -0
  10. package/dist/contracts/index.d.ts +6 -2
  11. package/dist/contracts/index.js +3 -1
  12. package/dist/contracts/organ-system.d.ts +49 -0
  13. package/dist/contracts/organ-system.js +67 -0
  14. package/dist/contracts/report-blocks.d.ts +564 -0
  15. package/dist/contracts/report-blocks.js +117 -0
  16. package/dist/contracts/report-reference.d.ts +459 -0
  17. package/dist/contracts/report-reference.js +256 -0
  18. package/dist/contracts/schemas/chat-events.d.ts +2 -0
  19. package/dist/contracts/schemas/chat-events.js +2 -0
  20. package/dist/contracts/severity.d.ts +15 -0
  21. package/dist/contracts/severity.js +10 -0
  22. package/dist/contracts/target-dossier.d.ts +8675 -12972
  23. package/dist/contracts/target-dossier.js +534 -591
  24. package/dist/data/safety-panel-schema.d.ts +18 -5
  25. package/dist/data/safety-panel-schema.js +4 -4
  26. package/dist/execution/artifact-metadata.js +1 -0
  27. package/dist/execution/report-runner.js +1 -3
  28. package/dist/execution/run-synthesis.js +2 -0
  29. package/dist/index.d.ts +6 -0
  30. package/dist/index.js +19 -0
  31. package/dist/lib/async-utils.d.ts +16 -4
  32. package/dist/lib/async-utils.js +20 -15
  33. package/dist/lib/host-concurrency.js +1 -0
  34. package/dist/loop/__fixtures__/scripted-provider.js +23 -2
  35. package/dist/loop/run-agent.js +58 -10
  36. package/dist/loop/tool-detail.d.ts +40 -0
  37. package/dist/loop/tool-detail.js +35 -3
  38. package/dist/loop/types.d.ts +13 -0
  39. package/dist/memory/thread-history.d.ts +10 -0
  40. package/dist/memory/thread-history.js +12 -1
  41. package/dist/memory/thread-store.d.ts +4 -4
  42. package/dist/memory/thread-store.js +18 -9
  43. package/dist/prompts/report-session.d.ts +1 -0
  44. package/dist/prompts/report-session.js +89 -0
  45. package/dist/prompts/target-assessment/briefs/executive-recommendation.d.ts +1 -1
  46. package/dist/prompts/target-assessment/briefs/executive-recommendation.js +5 -5
  47. package/dist/prompts/target-assessment/briefs/liability-bullets.d.ts +1 -1
  48. package/dist/prompts/target-assessment/briefs/liability-bullets.js +1 -1
  49. package/dist/prompts/target-assessment/briefs/target-organ-liabilities.d.ts +1 -1
  50. package/dist/prompts/target-assessment/briefs/target-organ-liabilities.js +11 -3
  51. package/dist/prompts/target-assessment/investigation/adversarial-critique.d.ts +1 -0
  52. package/dist/prompts/target-assessment/investigation/adversarial-critique.js +67 -0
  53. package/dist/prompts/target-assessment/investigation/claim-reverification.d.ts +1 -0
  54. package/dist/prompts/target-assessment/investigation/claim-reverification.js +49 -0
  55. package/dist/prompts/target-assessment/investigation/index.d.ts +3 -0
  56. package/dist/prompts/target-assessment/investigation/index.js +3 -0
  57. package/dist/prompts/target-assessment/investigation/mechanism-proposal.d.ts +1 -0
  58. package/dist/prompts/target-assessment/investigation/mechanism-proposal.js +49 -0
  59. package/dist/prompts/target-assessment/tox-voice/index.d.ts +1 -1
  60. package/dist/prompts/target-assessment/tox-voice/vocabulary.d.ts +8 -5
  61. package/dist/prompts/target-assessment/tox-voice/vocabulary.js +9 -20
  62. package/dist/providers/__fixtures__/session.d.ts +5 -4
  63. package/dist/providers/__fixtures__/session.js +4 -4
  64. package/dist/providers/ai-sdk.d.ts +77 -0
  65. package/dist/providers/ai-sdk.js +149 -19
  66. package/dist/providers/errors.d.ts +14 -0
  67. package/dist/providers/errors.js +103 -18
  68. package/dist/providers/types.d.ts +16 -0
  69. package/dist/providers/types.js +10 -1
  70. package/dist/report-model/block-walk.d.ts +56 -0
  71. package/dist/report-model/block-walk.js +89 -0
  72. package/dist/report-model/draft-finish.d.ts +60 -0
  73. package/dist/report-model/draft-finish.js +56 -0
  74. package/dist/report-model/draft-operations.d.ts +125 -0
  75. package/dist/report-model/draft-operations.js +341 -0
  76. package/dist/report-model/draft-read.d.ts +59 -0
  77. package/dist/report-model/draft-read.js +109 -0
  78. package/dist/report-model/draft.d.ts +51 -0
  79. package/dist/report-model/draft.js +32 -0
  80. package/dist/report-model/fixture-resolver.d.ts +8 -0
  81. package/dist/report-model/fixture-resolver.js +252 -0
  82. package/dist/report-model/pin-snapshot.d.ts +30 -0
  83. package/dist/report-model/pin-snapshot.js +40 -0
  84. package/dist/report-model/reference-resolver.d.ts +113 -0
  85. package/dist/report-model/reference-resolver.js +60 -0
  86. package/dist/report-model/structural-validation.d.ts +22 -0
  87. package/dist/report-model/structural-validation.js +68 -0
  88. package/dist/report-model/validate.d.ts +72 -0
  89. package/dist/report-model/validate.js +95 -0
  90. package/dist/report-render/chart.d.ts +33 -0
  91. package/dist/report-render/chart.js +538 -0
  92. package/dist/report-render/page.d.ts +127 -0
  93. package/dist/report-render/page.js +307 -0
  94. package/dist/report-render/references.d.ts +32 -0
  95. package/dist/report-render/references.js +44 -0
  96. package/dist/report-render/render.d.ts +25 -0
  97. package/dist/report-render/render.js +125 -0
  98. package/dist/report-render/script-json.d.ts +13 -0
  99. package/dist/report-render/script-json.js +15 -0
  100. package/dist/report-render/types.d.ts +39 -0
  101. package/dist/report-render/types.js +10 -0
  102. package/dist/report-render/value-bridge.d.ts +62 -0
  103. package/dist/report-render/value-bridge.js +82 -0
  104. package/dist/report-render/views/chart-view.d.ts +11 -0
  105. package/dist/report-render/views/chart-view.js +23 -0
  106. package/dist/report-render/views/page-view.d.ts +20 -0
  107. package/dist/report-render/views/page-view.js +49 -0
  108. package/dist/report-render/views/prose.d.ts +28 -0
  109. package/dist/report-render/views/prose.js +75 -0
  110. package/dist/report-render/views/references-view.d.ts +20 -0
  111. package/dist/report-render/views/references-view.js +64 -0
  112. package/dist/report-render/views/values.d.ts +42 -0
  113. package/dist/report-render/views/values.js +43 -0
  114. package/dist/runtime/assemble.d.ts +15 -0
  115. package/dist/runtime/assemble.js +28 -6
  116. package/dist/runtime/boot.d.ts +3 -3
  117. package/dist/runtime/boot.js +15 -4
  118. package/dist/runtime/dbos.d.ts +4 -4
  119. package/dist/state/artifacts.d.ts +16 -0
  120. package/dist/state/artifacts.js +18 -0
  121. package/dist/state/init.js +54 -0
  122. package/dist/state/purge-analysis.js +2 -0
  123. package/dist/state/report-session-state.d.ts +112 -0
  124. package/dist/state/report-session-state.js +150 -0
  125. package/dist/state/report-versions.d.ts +129 -0
  126. package/dist/state/report-versions.js +167 -0
  127. package/dist/state/snapshot-parse.d.ts +34 -0
  128. package/dist/state/snapshot-parse.js +82 -0
  129. package/dist/tasks/data-profile.js +1 -0
  130. package/dist/tools/ad-hoc-router.d.ts +7 -2
  131. package/dist/tools/ad-hoc-router.js +2 -1
  132. package/dist/tools/bio/chembl.js +1 -0
  133. package/dist/tools/bio/comptox.js +1 -0
  134. package/dist/tools/bio/drug-gene-interactions.js +1 -0
  135. package/dist/tools/bio/gene-disease-evidence.js +1 -0
  136. package/dist/tools/bio/gene-preclinical-profile.js +1 -0
  137. package/dist/tools/bio/keys.d.ts +3 -2
  138. package/dist/tools/bio/keys.js +3 -2
  139. package/dist/tools/bio/lookup-annotation.js +1 -0
  140. package/dist/tools/bio/opentargets.d.ts +3 -3
  141. package/dist/tools/bio/opentargets.js +4 -3
  142. package/dist/tools/bio/pubchem.js +1 -0
  143. package/dist/tools/bio/search-clinical-trials.js +1 -0
  144. package/dist/tools/bio/search-faers.js +1 -0
  145. package/dist/tools/bio/search-geo-datasets.js +1 -0
  146. package/dist/tools/bio/search-interactions.js +1 -0
  147. package/dist/tools/bio/target-safety.d.ts +4 -6
  148. package/dist/tools/bio/target-safety.js +7 -6
  149. package/dist/tools/define-tool.d.ts +19 -12
  150. package/dist/tools/define-tool.js +4 -2
  151. package/dist/tools/display/show-user.js +1 -0
  152. package/dist/tools/iterate-report.js +2 -0
  153. package/dist/tools/lib/chembl-client.d.ts +2 -0
  154. package/dist/tools/lib/chembl-client.js +1 -0
  155. package/dist/tools/lib/monarch-client.d.ts +42 -0
  156. package/dist/tools/lib/monarch-client.js +100 -0
  157. package/dist/tools/report/build-report.js +1 -0
  158. package/dist/tools/report/mint-preview-url.js +1 -0
  159. package/dist/tools/report/preview-snapshot.js +1 -0
  160. package/dist/tools/report/submit-report.js +1 -0
  161. package/dist/tools/report/version-fs.js +4 -0
  162. package/dist/tools/report-authoring/authoring-tools.d.ts +241 -0
  163. package/dist/tools/report-authoring/authoring-tools.js +460 -0
  164. package/dist/tools/report-session/index.d.ts +8 -0
  165. package/dist/tools/report-session/index.js +8 -0
  166. package/dist/tools/report-session/preview-report.d.ts +90 -0
  167. package/dist/tools/report-session/preview-report.js +245 -0
  168. package/dist/tools/research/context7-docs.js +2 -0
  169. package/dist/tools/research/generate-analogy-report.js +1 -0
  170. package/dist/tools/research/generate-plan.js +7 -2
  171. package/dist/tools/research/inspect-data-profile.js +4 -0
  172. package/dist/tools/research/literature-reviewer.js +1 -0
  173. package/dist/tools/research/search-arxiv.js +1 -0
  174. package/dist/tools/research/search-github-repos.js +1 -0
  175. package/dist/tools/research/search-semantic-scholar.js +1 -0
  176. package/dist/tools/sandbox/list-available-packages.js +23 -0
  177. package/dist/tools/sandbox/list-available-refs.js +36 -0
  178. package/dist/tools/sandbox/report-blocker.js +1 -0
  179. package/dist/tools/sandbox/skills.js +2 -0
  180. package/dist/tools/workspace/file-stat.js +1 -0
  181. package/dist/tools/workspace/show-file.js +2 -0
  182. package/dist/tools/workspace/show-plan.js +1 -0
  183. package/dist/workflows/execute-analysis.d.ts +5 -1
  184. package/dist/workflows/execute-analysis.js +5 -5
  185. package/dist/workflows/execute-target-assessment.d.ts +13 -2
  186. package/dist/workflows/execute-target-assessment.js +78 -16
  187. package/dist/workflows/target-assessment/assemblers/index.d.ts +1 -1
  188. package/dist/workflows/target-assessment/assemblers/index.js +1 -1
  189. package/dist/workflows/target-assessment/assemblers/literature.d.ts +9 -27
  190. package/dist/workflows/target-assessment/assemblers/literature.js +32 -48
  191. package/dist/workflows/target-assessment/assemblers/orchestrator.d.ts +17 -9
  192. package/dist/workflows/target-assessment/assemblers/orchestrator.js +195 -85
  193. package/dist/workflows/target-assessment/assemblers/safety.d.ts +70 -48
  194. package/dist/workflows/target-assessment/assemblers/safety.js +125 -42
  195. package/dist/workflows/target-assessment/collectors/index.d.ts +5 -2
  196. package/dist/workflows/target-assessment/collectors/index.js +48 -5
  197. package/dist/workflows/target-assessment/coverage.d.ts +43 -27
  198. package/dist/workflows/target-assessment/coverage.js +33 -29
  199. package/dist/workflows/target-assessment/fanout/index.js +1 -0
  200. package/dist/workflows/target-assessment/investigation/index.d.ts +97 -0
  201. package/dist/workflows/target-assessment/investigation/index.js +419 -0
  202. package/dist/workflows/target-assessment/lib/approval-precedents.d.ts +26 -5
  203. package/dist/workflows/target-assessment/lib/approval-precedents.js +95 -29
  204. package/dist/workflows/target-assessment/lib/citation-validator.js +1 -1
  205. package/dist/workflows/target-assessment/lib/clinical-consequence-annotator.d.ts +2 -2
  206. package/dist/workflows/target-assessment/lib/clinical-evidence-attribution.d.ts +2 -3
  207. package/dist/workflows/target-assessment/lib/clinical-evidence-attribution.js +0 -4
  208. package/dist/workflows/target-assessment/lib/compute-derived.d.ts +6 -5
  209. package/dist/workflows/target-assessment/lib/compute-derived.js +14 -5
  210. package/dist/workflows/target-assessment/lib/family-complex-supplement.d.ts +5 -6
  211. package/dist/workflows/target-assessment/lib/family-complex-supplement.js +2 -3
  212. package/dist/workflows/target-assessment/lib/fda-label-safety.d.ts +72 -0
  213. package/dist/workflows/target-assessment/lib/fda-label-safety.js +166 -0
  214. package/dist/workflows/target-assessment/lib/heterodimer-filter.d.ts +0 -9
  215. package/dist/workflows/target-assessment/lib/heterodimer-filter.js +0 -10
  216. package/dist/workflows/target-assessment/lib/hpo-organ-map.d.ts +34 -0
  217. package/dist/workflows/target-assessment/lib/hpo-organ-map.js +63 -0
  218. package/dist/workflows/target-assessment/lib/impc-organ-map.d.ts +19 -0
  219. package/dist/workflows/target-assessment/lib/impc-organ-map.js +39 -0
  220. package/dist/workflows/target-assessment/lib/meddra-organ-map.d.ts +24 -14
  221. package/dist/workflows/target-assessment/lib/meddra-organ-map.js +59 -47
  222. package/dist/workflows/target-assessment/lib/recommendation-sanitizer.js +1 -1
  223. package/dist/workflows/target-assessment/lib/regulatory-actions.d.ts +2 -3
  224. package/dist/workflows/target-assessment/lib/regulatory-actions.js +33 -4
  225. package/dist/workflows/target-assessment/lib/safety-corroboration.d.ts +44 -0
  226. package/dist/workflows/target-assessment/lib/safety-corroboration.js +273 -0
  227. package/dist/workflows/target-assessment/lib/target-identity-filter.d.ts +5 -7
  228. package/dist/workflows/target-assessment/lib/target-identity-filter.js +5 -7
  229. package/dist/workflows/target-assessment/metrics.d.ts +1 -6
  230. package/dist/workflows/target-assessment/metrics.js +1 -13
  231. package/dist/workflows/target-assessment/phase4-assemble.d.ts +2147 -807
  232. package/dist/workflows/target-assessment/phase4-assemble.js +19 -19
  233. package/dist/workflows/target-assessment/phase5-persist.d.ts +20 -21
  234. package/dist/workflows/target-assessment/phase5-persist.js +56 -173
  235. package/dist/workflows/target-assessment/schemas.d.ts +46 -1
  236. package/dist/workflows/target-assessment/schemas.js +19 -0
  237. package/dist/workflows/target-assessment/steps/fanout/polypharm-for-one-modulator-step.d.ts +1 -0
  238. package/dist/workflows/target-assessment/steps/fanout/polypharm-for-one-modulator-step.js +2 -0
  239. package/dist/workflows/target-assessment/steps/phase2-aggregate.d.ts +26 -62
  240. package/dist/workflows/target-assessment/steps/phase2-aggregate.js +0 -4
  241. package/dist/workflows/target-assessment/steps/phase3-aggregate.d.ts +27 -154
  242. package/dist/workflows/target-assessment/steps/phase3-aggregate.js +0 -6
  243. package/dist/workflows/target-assessment/steps/synthesis/diagnostics.d.ts +0 -6
  244. package/dist/workflows/target-assessment/steps/synthesis/diagnostics.js +0 -18
  245. package/dist/workflows/target-assessment/sub-workflows/per-modulator-polypharm.d.ts +1 -0
  246. package/dist/workflows/target-assessment/synthesis/index.d.ts +52 -5
  247. package/dist/workflows/target-assessment/synthesis/index.js +4 -1
  248. package/dist/workflows/target-assessment/synthesis-probes.d.ts +3 -3
  249. package/package.json +4 -1
package/dist/workflows/target-assessment/phase4-assemble.d.ts CHANGED
@@ -1,24 +1,25 @@
1
1
  /**
2
- * Phase 4 — deterministic dossier assembly.
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+ * Phase 4 — dossier assembly.
3
3
  *
4
- * Pure function over a Phase-3 bundle. Calls `assembleDossier` (~3.5K LOC
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- * of pure compute) and returns the assembled `DossierV4Body`. The Phase-5
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- * synthesis sections (translational commentary, liability bullets, safety-
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- * flags trail) are stamped by the Phase-5 persist step after this step
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- * completes.
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+ * Calls `assembleDossier` (~3.5K LOC of aggregation over the Phase-3 bundle)
5
+ * and returns the assembled `DossierBody`. The safety-corroboration and
6
+ * claim-investigation sections are stamped by the workflow body between this
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+ * step and synthesis; the Phase-5 synthesis sections (translational commentary,
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+ * liability bullets, safety-flags trail) are stamped by the Phase-5 persist
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+ * step.
9
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  *
10
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  * The DBOS workflow body wraps this in `DBOS.runStep({name: "phase4-assemble"})`
11
12
  * so recovery on a fresh replica replays the cached output without re-running
12
- * the ~1-3 sec compute.
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- *
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- * `assembleDossier` accepts an optional `ClinicalConsequenceAnnotatorDeps`
15
- * bundle that is threaded through to `annotateOffTargetPanel`. For the
16
- * DBOS workflow the parameter is undefined — the annotator falls back to
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- * its DB cache + no-LLM path. Threading a real deps bundle (provider +
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- * session + model) through Phase-4 is a follow-up tracked in §17 cleanup.
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+ * the compute. Replay caching earns its keep here because `annotatorDeps`
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+ * carries the per-row clinical-consequence annotator's LLM seam: assembly makes
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+ * bounded model calls for off-target rows that have no cached annotation. Those
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+ * calls are per-row best-effort — a failure leaves the row's original fallback —
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+ * and their results are cached in Postgres, so a repeat assessment of the same
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+ * target reaches them without an LLM call at all.
19
19
  */
20
20
  import type { Pool } from "pg";
21
21
  import { z } from "zod";
22
+ import type { ClinicalConsequenceAnnotatorDeps } from "./lib/clinical-consequence-annotator.js";
22
23
  import type { Phase3Bundle } from "./steps/phase3-aggregate.js";
23
24
  import { Phase3BundleSchema } from "./steps/phase3-aggregate.js";
24
25
  export declare const Phase4OutputSchema: z.ZodObject<{
@@ -45,6 +46,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
45
46
  evidence: z.ZodArray<z.ZodObject<{
46
47
  pmid: z.ZodOptional<z.ZodString>;
47
48
  doi: z.ZodOptional<z.ZodString>;
49
+ accession: z.ZodOptional<z.ZodString>;
48
50
  source: z.ZodString;
49
51
  predicate: z.ZodOptional<z.ZodString>;
50
52
  score: z.ZodOptional<z.ZodNumber>;
@@ -62,6 +64,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
62
64
  }, z.core.$strip>>;
63
65
  }, z.core.$strip>>;
64
66
  }, z.core.$strip>;
67
+ dropped_count: z.ZodOptional<z.ZodNumber>;
65
68
  inference_path: z.ZodOptional<z.ZodString>;
66
69
  truncated: z.ZodOptional<z.ZodBoolean>;
67
70
  }, z.core.$strip>, z.ZodObject<{
@@ -71,6 +74,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
71
74
  source: z.ZodOptional<z.ZodString>;
72
75
  }, z.core.$strip>>;
73
76
  inference_path: z.ZodOptional<z.ZodString>;
77
+ }, z.core.$strip>, z.ZodObject<{
78
+ coverage: z.ZodLiteral<"filtered">;
79
+ filter: z.ZodString;
80
+ dropped_count: z.ZodNumber;
81
+ inference_path: z.ZodOptional<z.ZodString>;
74
82
  }, z.core.$strip>, z.ZodObject<{
75
83
  coverage: z.ZodLiteral<"not_loaded">;
76
84
  reason: z.ZodOptional<z.ZodString>;
@@ -97,6 +105,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
97
105
  preferred_modality: z.ZodNullable<z.ZodString>;
98
106
  drug_molecule_types_present: z.ZodDefault<z.ZodArray<z.ZodString>>;
99
107
  }, z.core.$strip>;
108
+ dropped_count: z.ZodOptional<z.ZodNumber>;
100
109
  inference_path: z.ZodOptional<z.ZodString>;
101
110
  truncated: z.ZodOptional<z.ZodBoolean>;
102
111
  }, z.core.$strip>, z.ZodObject<{
@@ -106,11 +115,15 @@ export declare const Phase4OutputSchema: z.ZodObject<{
106
115
  source: z.ZodOptional<z.ZodString>;
107
116
  }, z.core.$strip>>;
108
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  inference_path: z.ZodOptional<z.ZodString>;
118
+ }, z.core.$strip>, z.ZodObject<{
119
+ coverage: z.ZodLiteral<"filtered">;
120
+ filter: z.ZodString;
121
+ dropped_count: z.ZodNumber;
122
+ inference_path: z.ZodOptional<z.ZodString>;
109
123
  }, z.core.$strip>, z.ZodObject<{
110
124
  coverage: z.ZodLiteral<"not_loaded">;
111
125
  reason: z.ZodOptional<z.ZodString>;
112
126
  }, z.core.$strip>], "coverage">;
113
- schema_version: z.ZodLiteral<"4">;
114
127
  off_target_panel: z.ZodDiscriminatedUnion<[z.ZodObject<{
115
128
  coverage: z.ZodLiteral<"available">;
116
129
  data: z.ZodObject<{
@@ -120,7 +133,26 @@ export declare const Phase4OutputSchema: z.ZodObject<{
120
133
  target_class: z.ZodOptional<z.ZodString>;
121
134
  pchembl: z.ZodNumber;
122
135
  is_safety_panel_target: z.ZodBoolean;
123
- organ_system: z.ZodNullable<z.ZodString>;
136
+ organ_system: z.ZodNullable<z.ZodEnum<{
137
+ hematologic: "hematologic";
138
+ metabolic: "metabolic";
139
+ immune: "immune";
140
+ hepatic: "hepatic";
141
+ musculoskeletal: "musculoskeletal";
142
+ cns: "cns";
143
+ renal: "renal";
144
+ reproductive: "reproductive";
145
+ respiratory: "respiratory";
146
+ cardiac: "cardiac";
147
+ vascular: "vascular";
148
+ pns: "pns";
149
+ gi: "gi";
150
+ pancreas: "pancreas";
151
+ endocrine_thyroid: "endocrine_thyroid";
152
+ dermatologic: "dermatologic";
153
+ ocular: "ocular";
154
+ oncology: "oncology";
155
+ }>>;
124
156
  clinical_consequence: z.ZodNullable<z.ZodString>;
125
157
  selectivity: z.ZodUnion<readonly [z.ZodObject<{
126
158
  vs_primary_potency: z.ZodObject<{
@@ -137,28 +169,35 @@ export declare const Phase4OutputSchema: z.ZodObject<{
137
169
  reason: z.ZodString;
138
170
  }, z.core.$strip>]>;
139
171
  selectivity_window_below_threshold: z.ZodBoolean;
140
- evidence: z.ZodArray<z.ZodObject<{
141
- pmid: z.ZodOptional<z.ZodString>;
142
- doi: z.ZodOptional<z.ZodString>;
143
- source: z.ZodString;
144
- predicate: z.ZodOptional<z.ZodString>;
145
- score: z.ZodOptional<z.ZodNumber>;
146
- strength: z.ZodOptional<z.ZodString>;
147
- is_human: z.ZodOptional<z.ZodBoolean>;
148
- is_clinical: z.ZodOptional<z.ZodBoolean>;
149
- excerpt: z.ZodOptional<z.ZodString>;
150
- metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
151
- regulatory_reference: z.ZodOptional<z.ZodObject<{
152
- document: z.ZodString;
153
- section: z.ZodOptional<z.ZodString>;
154
- doc_id: z.ZodOptional<z.ZodString>;
155
- doc_url: z.ZodOptional<z.ZodString>;
156
- }, z.core.$strip>>;
157
- }, z.core.$strip>>;
158
172
  metadata: z.ZodOptional<z.ZodObject<{
159
173
  merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
160
174
  }, z.core.$strip>>;
161
175
  relationship: z.ZodLiteral<"off_target">;
176
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
177
+ state: z.ZodLiteral<"scored">;
178
+ evidence: z.ZodArray<z.ZodObject<{
179
+ pmid: z.ZodOptional<z.ZodString>;
180
+ doi: z.ZodOptional<z.ZodString>;
181
+ accession: z.ZodOptional<z.ZodString>;
182
+ source: z.ZodString;
183
+ predicate: z.ZodOptional<z.ZodString>;
184
+ score: z.ZodOptional<z.ZodNumber>;
185
+ strength: z.ZodOptional<z.ZodString>;
186
+ is_human: z.ZodOptional<z.ZodBoolean>;
187
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
188
+ excerpt: z.ZodOptional<z.ZodString>;
189
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
190
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
191
+ document: z.ZodString;
192
+ section: z.ZodOptional<z.ZodString>;
193
+ doc_id: z.ZodOptional<z.ZodString>;
194
+ doc_url: z.ZodOptional<z.ZodString>;
195
+ }, z.core.$strip>>;
196
+ }, z.core.$strip>>;
197
+ }, z.core.$strip>, z.ZodObject<{
198
+ state: z.ZodLiteral<"unknown">;
199
+ reason: z.ZodString;
200
+ }, z.core.$strip>], "state">;
162
201
  }, z.core.$strip>>;
163
202
  excluded_rows: z.ZodArray<z.ZodObject<{
164
203
  off_target_id: z.ZodNullable<z.ZodString>;
@@ -166,7 +205,26 @@ export declare const Phase4OutputSchema: z.ZodObject<{
166
205
  target_class: z.ZodOptional<z.ZodString>;
167
206
  pchembl: z.ZodNumber;
168
207
  is_safety_panel_target: z.ZodBoolean;
169
- organ_system: z.ZodNullable<z.ZodString>;
208
+ organ_system: z.ZodNullable<z.ZodEnum<{
209
+ hematologic: "hematologic";
210
+ metabolic: "metabolic";
211
+ immune: "immune";
212
+ hepatic: "hepatic";
213
+ musculoskeletal: "musculoskeletal";
214
+ cns: "cns";
215
+ renal: "renal";
216
+ reproductive: "reproductive";
217
+ respiratory: "respiratory";
218
+ cardiac: "cardiac";
219
+ vascular: "vascular";
220
+ pns: "pns";
221
+ gi: "gi";
222
+ pancreas: "pancreas";
223
+ endocrine_thyroid: "endocrine_thyroid";
224
+ dermatologic: "dermatologic";
225
+ ocular: "ocular";
226
+ oncology: "oncology";
227
+ }>>;
170
228
  clinical_consequence: z.ZodNullable<z.ZodString>;
171
229
  selectivity: z.ZodUnion<readonly [z.ZodObject<{
172
230
  vs_primary_potency: z.ZodObject<{
@@ -183,9 +241,19 @@ export declare const Phase4OutputSchema: z.ZodObject<{
183
241
  reason: z.ZodString;
184
242
  }, z.core.$strip>]>;
185
243
  selectivity_window_below_threshold: z.ZodBoolean;
244
+ metadata: z.ZodOptional<z.ZodObject<{
245
+ merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
246
+ }, z.core.$strip>>;
247
+ relationship: z.ZodEnum<{
248
+ intended_co_target: "intended_co_target";
249
+ on_target_self_hit: "on_target_self_hit";
250
+ obligate_cofactor: "obligate_cofactor";
251
+ }>;
252
+ reason: z.ZodString;
186
253
  evidence: z.ZodArray<z.ZodObject<{
187
254
  pmid: z.ZodOptional<z.ZodString>;
188
255
  doi: z.ZodOptional<z.ZodString>;
256
+ accession: z.ZodOptional<z.ZodString>;
189
257
  source: z.ZodString;
190
258
  predicate: z.ZodOptional<z.ZodString>;
191
259
  score: z.ZodOptional<z.ZodNumber>;
@@ -201,17 +269,9 @@ export declare const Phase4OutputSchema: z.ZodObject<{
201
269
  doc_url: z.ZodOptional<z.ZodString>;
202
270
  }, z.core.$strip>>;
203
271
  }, z.core.$strip>>;
204
- metadata: z.ZodOptional<z.ZodObject<{
205
- merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
206
- }, z.core.$strip>>;
207
- relationship: z.ZodEnum<{
208
- intended_co_target: "intended_co_target";
209
- on_target_self_hit: "on_target_self_hit";
210
- obligate_cofactor: "obligate_cofactor";
211
- }>;
212
- reason: z.ZodString;
213
272
  }, z.core.$strip>>;
214
273
  }, z.core.$strip>;
274
+ dropped_count: z.ZodOptional<z.ZodNumber>;
215
275
  inference_path: z.ZodOptional<z.ZodString>;
216
276
  truncated: z.ZodOptional<z.ZodBoolean>;
217
277
  }, z.core.$strip>, z.ZodObject<{
@@ -221,6 +281,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
221
281
  source: z.ZodOptional<z.ZodString>;
222
282
  }, z.core.$strip>>;
223
283
  inference_path: z.ZodOptional<z.ZodString>;
284
+ }, z.core.$strip>, z.ZodObject<{
285
+ coverage: z.ZodLiteral<"filtered">;
286
+ filter: z.ZodString;
287
+ dropped_count: z.ZodNumber;
288
+ inference_path: z.ZodOptional<z.ZodString>;
224
289
  }, z.core.$strip>, z.ZodObject<{
225
290
  coverage: z.ZodLiteral<"not_loaded">;
226
291
  reason: z.ZodOptional<z.ZodString>;
@@ -237,6 +302,31 @@ export declare const Phase4OutputSchema: z.ZodObject<{
237
302
  high_safety_organ_expression: "high_safety_organ_expression";
238
303
  broad_expression: "broad_expression";
239
304
  }>;
305
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
306
+ state: z.ZodLiteral<"scored">;
307
+ evidence: z.ZodArray<z.ZodObject<{
308
+ pmid: z.ZodOptional<z.ZodString>;
309
+ doi: z.ZodOptional<z.ZodString>;
310
+ accession: z.ZodOptional<z.ZodString>;
311
+ source: z.ZodString;
312
+ predicate: z.ZodOptional<z.ZodString>;
313
+ score: z.ZodOptional<z.ZodNumber>;
314
+ strength: z.ZodOptional<z.ZodString>;
315
+ is_human: z.ZodOptional<z.ZodBoolean>;
316
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
317
+ excerpt: z.ZodOptional<z.ZodString>;
318
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
319
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
320
+ document: z.ZodString;
321
+ section: z.ZodOptional<z.ZodString>;
322
+ doc_id: z.ZodOptional<z.ZodString>;
323
+ doc_url: z.ZodOptional<z.ZodString>;
324
+ }, z.core.$strip>>;
325
+ }, z.core.$strip>>;
326
+ }, z.core.$strip>, z.ZodObject<{
327
+ state: z.ZodLiteral<"unknown">;
328
+ reason: z.ZodString;
329
+ }, z.core.$strip>], "state">;
240
330
  }, z.core.$strip>>;
241
331
  liability_bullets_dropped: z.ZodOptional<z.ZodArray<z.ZodObject<{
242
332
  text: z.ZodString;
@@ -257,35 +347,213 @@ export declare const Phase4OutputSchema: z.ZodObject<{
257
347
  inferred_therapeutic_area: z.ZodNullable<z.ZodString>;
258
348
  no_liabilities_disclosure: z.ZodOptional<z.ZodString>;
259
349
  }, z.core.$strict>;
260
- analytics: z.ZodObject<{
261
- evidence_conflicts: z.ZodDiscriminatedUnion<[z.ZodObject<{
350
+ entity: z.ZodObject<{
351
+ canonicalId: z.ZodString;
352
+ symbol: z.ZodString;
353
+ displayName: z.ZodString;
354
+ entityType: z.ZodEnum<{
355
+ gene: "gene";
356
+ rna: "rna";
357
+ protein: "protein";
358
+ complex: "complex";
359
+ }>;
360
+ ontology: z.ZodString;
361
+ identifiers: z.ZodObject<{
362
+ hgnc: z.ZodOptional<z.ZodString>;
363
+ ensembl: z.ZodOptional<z.ZodString>;
364
+ uniprot: z.ZodOptional<z.ZodString>;
365
+ chembl: z.ZodOptional<z.ZodString>;
366
+ ncbiGene: z.ZodOptional<z.ZodString>;
367
+ }, z.core.$strip>;
368
+ synonyms: z.ZodDefault<z.ZodArray<z.ZodString>>;
369
+ proteinFamily: z.ZodOptional<z.ZodString>;
370
+ }, z.core.$strip>;
371
+ indications: z.ZodDiscriminatedUnion<[z.ZodObject<{
372
+ coverage: z.ZodLiteral<"available">;
373
+ data: z.ZodObject<{
374
+ rows: z.ZodArray<z.ZodObject<{
375
+ disease_id: z.ZodString;
376
+ disease_name: z.ZodString;
377
+ composite_score: z.ZodNumber;
378
+ composite_score_breakdown: z.ZodOptional<z.ZodObject<{
379
+ base: z.ZodNumber;
380
+ source_bonuses: z.ZodRecord<z.ZodString, z.ZodNumber>;
381
+ paper_depth: z.ZodNumber;
382
+ }, z.core.$strip>>;
383
+ evidence_score: z.ZodNumber;
384
+ source_count: z.ZodNumber;
385
+ unique_paper_count: z.ZodNumber;
386
+ sources: z.ZodArray<z.ZodString>;
387
+ evidence: z.ZodArray<z.ZodObject<{
388
+ pmid: z.ZodOptional<z.ZodString>;
389
+ doi: z.ZodOptional<z.ZodString>;
390
+ accession: z.ZodOptional<z.ZodString>;
391
+ source: z.ZodString;
392
+ predicate: z.ZodOptional<z.ZodString>;
393
+ score: z.ZodOptional<z.ZodNumber>;
394
+ strength: z.ZodOptional<z.ZodString>;
395
+ is_human: z.ZodOptional<z.ZodBoolean>;
396
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
397
+ excerpt: z.ZodOptional<z.ZodString>;
398
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
399
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
400
+ document: z.ZodString;
401
+ section: z.ZodOptional<z.ZodString>;
402
+ doc_id: z.ZodOptional<z.ZodString>;
403
+ doc_url: z.ZodOptional<z.ZodString>;
404
+ }, z.core.$strip>>;
405
+ }, z.core.$strip>>;
406
+ }, z.core.$strip>>;
407
+ excluded_unsupported_count: z.ZodOptional<z.ZodNumber>;
408
+ unsupported_associations: z.ZodOptional<z.ZodArray<z.ZodObject<{
409
+ disease_id: z.ZodString;
410
+ disease_name: z.ZodString;
411
+ }, z.core.$strip>>>;
412
+ }, z.core.$strip>;
413
+ dropped_count: z.ZodOptional<z.ZodNumber>;
414
+ inference_path: z.ZodOptional<z.ZodString>;
415
+ truncated: z.ZodOptional<z.ZodBoolean>;
416
+ }, z.core.$strip>, z.ZodObject<{
417
+ coverage: z.ZodLiteral<"queried_no_data">;
418
+ error: z.ZodOptional<z.ZodObject<{
419
+ message: z.ZodString;
420
+ source: z.ZodOptional<z.ZodString>;
421
+ }, z.core.$strip>>;
422
+ inference_path: z.ZodOptional<z.ZodString>;
423
+ }, z.core.$strip>, z.ZodObject<{
424
+ coverage: z.ZodLiteral<"filtered">;
425
+ filter: z.ZodString;
426
+ dropped_count: z.ZodNumber;
427
+ inference_path: z.ZodOptional<z.ZodString>;
428
+ }, z.core.$strip>, z.ZodObject<{
429
+ coverage: z.ZodLiteral<"not_loaded">;
430
+ reason: z.ZodOptional<z.ZodString>;
431
+ }, z.core.$strip>], "coverage">;
432
+ clinical_development: z.ZodObject<{
433
+ trials: z.ZodDiscriminatedUnion<[z.ZodObject<{
262
434
  coverage: z.ZodLiteral<"available">;
263
435
  data: z.ZodObject<{
264
436
  rows: z.ZodArray<z.ZodObject<{
265
- evidence_item_id: z.ZodString;
266
- predicate: z.ZodString;
267
- contradicting_predicates: z.ZodArray<z.ZodString>;
268
- surfaced_in_section: z.ZodString;
269
- evidence: z.ZodArray<z.ZodObject<{
270
- pmid: z.ZodOptional<z.ZodString>;
271
- doi: z.ZodOptional<z.ZodString>;
272
- source: z.ZodString;
273
- predicate: z.ZodOptional<z.ZodString>;
274
- score: z.ZodOptional<z.ZodNumber>;
275
- strength: z.ZodOptional<z.ZodString>;
276
- is_human: z.ZodOptional<z.ZodBoolean>;
277
- is_clinical: z.ZodOptional<z.ZodBoolean>;
278
- excerpt: z.ZodOptional<z.ZodString>;
279
- metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
280
- regulatory_reference: z.ZodOptional<z.ZodObject<{
281
- document: z.ZodString;
282
- section: z.ZodOptional<z.ZodString>;
283
- doc_id: z.ZodOptional<z.ZodString>;
284
- doc_url: z.ZodOptional<z.ZodString>;
437
+ nct_id: z.ZodString;
438
+ title: z.ZodString;
439
+ phase: z.ZodNullable<z.ZodString>;
440
+ status: z.ZodString;
441
+ conditions: z.ZodArray<z.ZodString>;
442
+ start_date: z.ZodNullable<z.ZodString>;
443
+ completion_date: z.ZodNullable<z.ZodString>;
444
+ match_confidence: z.ZodEnum<{
445
+ high: "high";
446
+ medium: "medium";
447
+ low: "low";
448
+ off_target: "off_target";
449
+ }>;
450
+ attribution: z.ZodObject<{
451
+ relationship: z.ZodEnum<{
452
+ unknown: "unknown";
453
+ related_family_target: "related_family_target";
454
+ condition_only: "condition_only";
455
+ direct_modulator: "direct_modulator";
456
+ class_modulator: "class_modulator";
457
+ target_biomarker: "target_biomarker";
458
+ pathway_biomarker: "pathway_biomarker";
459
+ unrelated: "unrelated";
460
+ }>;
461
+ evidence_role: z.ZodEnum<{
462
+ supports_target: "supports_target";
463
+ contextual: "contextual";
464
+ excluded: "excluded";
465
+ }>;
466
+ basis: z.ZodArray<z.ZodObject<{
467
+ kind: z.ZodEnum<{
468
+ mechanism_target_match: "mechanism_target_match";
469
+ known_class_drug: "known_class_drug";
470
+ therapeutic_program_match: "therapeutic_program_match";
471
+ related_family_target: "related_family_target";
472
+ biomarker_endpoint: "biomarker_endpoint";
473
+ condition_only: "condition_only";
474
+ text_match: "text_match";
475
+ manual: "manual";
476
+ }>;
477
+ source: z.ZodString;
478
+ excerpt: z.ZodOptional<z.ZodString>;
479
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
285
480
  }, z.core.$strip>>;
286
- }, z.core.$strip>>;
481
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
482
+ name: z.ZodString;
483
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
484
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
485
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
486
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
487
+ resolver_source: z.ZodString;
488
+ }, z.core.$strip>>>;
489
+ exclusion_reason: z.ZodOptional<z.ZodString>;
490
+ }, z.core.$strip>;
491
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
492
+ }, z.core.$strip>>;
493
+ excluded_rows: z.ZodDefault<z.ZodArray<z.ZodObject<{
494
+ nct_id: z.ZodString;
495
+ title: z.ZodString;
496
+ phase: z.ZodNullable<z.ZodString>;
497
+ status: z.ZodString;
498
+ conditions: z.ZodArray<z.ZodString>;
499
+ start_date: z.ZodNullable<z.ZodString>;
500
+ completion_date: z.ZodNullable<z.ZodString>;
501
+ match_confidence: z.ZodEnum<{
502
+ high: "high";
503
+ medium: "medium";
504
+ low: "low";
505
+ off_target: "off_target";
506
+ }>;
507
+ attribution: z.ZodObject<{
508
+ relationship: z.ZodEnum<{
509
+ unknown: "unknown";
510
+ related_family_target: "related_family_target";
511
+ condition_only: "condition_only";
512
+ direct_modulator: "direct_modulator";
513
+ class_modulator: "class_modulator";
514
+ target_biomarker: "target_biomarker";
515
+ pathway_biomarker: "pathway_biomarker";
516
+ unrelated: "unrelated";
517
+ }>;
518
+ evidence_role: z.ZodEnum<{
519
+ supports_target: "supports_target";
520
+ contextual: "contextual";
521
+ excluded: "excluded";
522
+ }>;
523
+ basis: z.ZodArray<z.ZodObject<{
524
+ kind: z.ZodEnum<{
525
+ mechanism_target_match: "mechanism_target_match";
526
+ known_class_drug: "known_class_drug";
527
+ therapeutic_program_match: "therapeutic_program_match";
528
+ related_family_target: "related_family_target";
529
+ biomarker_endpoint: "biomarker_endpoint";
530
+ condition_only: "condition_only";
531
+ text_match: "text_match";
532
+ manual: "manual";
533
+ }>;
534
+ source: z.ZodString;
535
+ excerpt: z.ZodOptional<z.ZodString>;
536
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
537
+ }, z.core.$strip>>;
538
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
539
+ name: z.ZodString;
540
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
541
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
542
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
543
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
544
+ resolver_source: z.ZodString;
545
+ }, z.core.$strip>>>;
546
+ exclusion_reason: z.ZodOptional<z.ZodString>;
547
+ }, z.core.$strip>;
548
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
549
+ }, z.core.$strip>>>;
550
+ selection_criteria: z.ZodOptional<z.ZodObject<{
551
+ derived_from: z.ZodOptional<z.ZodString>;
552
+ min_confidence: z.ZodOptional<z.ZodString>;
553
+ excluded_off_target_count: z.ZodOptional<z.ZodNumber>;
287
554
  }, z.core.$strip>>;
288
555
  }, z.core.$strip>;
556
+ dropped_count: z.ZodOptional<z.ZodNumber>;
289
557
  inference_path: z.ZodOptional<z.ZodString>;
290
558
  truncated: z.ZodOptional<z.ZodBoolean>;
291
559
  }, z.core.$strip>, z.ZodObject<{
@@ -296,63 +564,94 @@ export declare const Phase4OutputSchema: z.ZodObject<{
296
564
  }, z.core.$strip>>;
297
565
  inference_path: z.ZodOptional<z.ZodString>;
298
566
  }, z.core.$strip>, z.ZodObject<{
299
- coverage: z.ZodLiteral<"not_loaded">;
300
- reason: z.ZodOptional<z.ZodString>;
301
- }, z.core.$strip>], "coverage">;
302
- evidence_timeline: z.ZodDiscriminatedUnion<[z.ZodObject<{
303
- coverage: z.ZodLiteral<"available">;
304
- data: z.ZodObject<{
305
- histogram: z.ZodRecord<z.ZodString, z.ZodNumber>;
306
- first_reported_year: z.ZodNullable<z.ZodNumber>;
307
- last_reported_year: z.ZodNullable<z.ZodNumber>;
308
- trend_labels: z.ZodArray<z.ZodString>;
309
- }, z.core.$strip>;
310
- inference_path: z.ZodOptional<z.ZodString>;
311
- truncated: z.ZodOptional<z.ZodBoolean>;
312
- }, z.core.$strip>, z.ZodObject<{
313
- coverage: z.ZodLiteral<"queried_no_data">;
314
- error: z.ZodOptional<z.ZodObject<{
315
- message: z.ZodString;
316
- source: z.ZodOptional<z.ZodString>;
317
- }, z.core.$strip>>;
567
+ coverage: z.ZodLiteral<"filtered">;
568
+ filter: z.ZodString;
569
+ dropped_count: z.ZodNumber;
318
570
  inference_path: z.ZodOptional<z.ZodString>;
319
571
  }, z.core.$strip>, z.ZodObject<{
320
572
  coverage: z.ZodLiteral<"not_loaded">;
321
573
  reason: z.ZodOptional<z.ZodString>;
322
574
  }, z.core.$strip>], "coverage">;
323
- translational_chain: z.ZodDiscriminatedUnion<[z.ZodObject<{
575
+ outcomes: z.ZodDiscriminatedUnion<[z.ZodObject<{
324
576
  coverage: z.ZodLiteral<"available">;
325
577
  data: z.ZodObject<{
326
- tiers: z.ZodArray<z.ZodObject<{
327
- tier: z.ZodEnum<{
328
- computational: "computational";
329
- basic_in_vitro: "basic_in_vitro";
330
- complex_in_vitro: "complex_in_vitro";
331
- in_vivo_animal: "in_vivo_animal";
332
- ex_vivo_human: "ex_vivo_human";
333
- clinical: "clinical";
578
+ rows: z.ZodArray<z.ZodObject<{
579
+ nct_id: z.ZodString;
580
+ measure: z.ZodString;
581
+ outcome_type: z.ZodEnum<{
582
+ other: "other";
583
+ primary: "primary";
584
+ secondary: "secondary";
334
585
  }>;
335
- claim_count: z.ZodNumber;
336
- paper_count: z.ZodNumber;
586
+ description: z.ZodOptional<z.ZodString>;
587
+ time_frame: z.ZodOptional<z.ZodString>;
588
+ effect: z.ZodDiscriminatedUnion<[z.ZodObject<{
589
+ kind: z.ZodLiteral<"quantitative">;
590
+ value: z.ZodNumber;
591
+ ci_low: z.ZodOptional<z.ZodNumber>;
592
+ ci_high: z.ZodOptional<z.ZodNumber>;
593
+ units: z.ZodString;
594
+ }, z.core.$strip>, z.ZodObject<{
595
+ kind: z.ZodLiteral<"qualitative">;
596
+ direction: z.ZodEnum<{
597
+ increase: "increase";
598
+ decrease: "decrease";
599
+ no_change: "no_change";
600
+ }>;
601
+ magnitude_label: z.ZodString;
602
+ }, z.core.$strip>, z.ZodObject<{
603
+ kind: z.ZodLiteral<"not_extracted">;
604
+ reason: z.ZodEnum<{
605
+ ctgov_no_numeric_result: "ctgov_no_numeric_result";
606
+ ctgov_no_result_groups: "ctgov_no_result_groups";
607
+ parse_failure: "parse_failure";
608
+ }>;
609
+ }, z.core.$strip>], "kind">;
610
+ attribution: z.ZodOptional<z.ZodObject<{
611
+ relationship: z.ZodEnum<{
612
+ unknown: "unknown";
613
+ related_family_target: "related_family_target";
614
+ condition_only: "condition_only";
615
+ direct_modulator: "direct_modulator";
616
+ class_modulator: "class_modulator";
617
+ target_biomarker: "target_biomarker";
618
+ pathway_biomarker: "pathway_biomarker";
619
+ unrelated: "unrelated";
620
+ }>;
621
+ evidence_role: z.ZodEnum<{
622
+ supports_target: "supports_target";
623
+ contextual: "contextual";
624
+ excluded: "excluded";
625
+ }>;
626
+ basis: z.ZodArray<z.ZodObject<{
627
+ kind: z.ZodEnum<{
628
+ mechanism_target_match: "mechanism_target_match";
629
+ known_class_drug: "known_class_drug";
630
+ therapeutic_program_match: "therapeutic_program_match";
631
+ related_family_target: "related_family_target";
632
+ biomarker_endpoint: "biomarker_endpoint";
633
+ condition_only: "condition_only";
634
+ text_match: "text_match";
635
+ manual: "manual";
636
+ }>;
637
+ source: z.ZodString;
638
+ excerpt: z.ZodOptional<z.ZodString>;
639
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
640
+ }, z.core.$strip>>;
641
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
642
+ name: z.ZodString;
643
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
644
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
645
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
646
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
647
+ resolver_source: z.ZodString;
648
+ }, z.core.$strip>>>;
649
+ exclusion_reason: z.ZodOptional<z.ZodString>;
650
+ }, z.core.$strip>>;
651
+ eligible_for_toxicology_aggregation: z.ZodDefault<z.ZodBoolean>;
337
652
  }, z.core.$strip>>;
338
- peak_evidence_tier: z.ZodNullable<z.ZodEnum<{
339
- computational: "computational";
340
- basic_in_vitro: "basic_in_vitro";
341
- complex_in_vitro: "complex_in_vitro";
342
- in_vivo_animal: "in_vivo_animal";
343
- ex_vivo_human: "ex_vivo_human";
344
- clinical: "clinical";
345
- }>>;
346
- progression_complete: z.ZodBoolean;
347
- weakest_progression_gap: z.ZodOptional<z.ZodNullable<z.ZodEnum<{
348
- computational: "computational";
349
- basic_in_vitro: "basic_in_vitro";
350
- complex_in_vitro: "complex_in_vitro";
351
- in_vivo_animal: "in_vivo_animal";
352
- ex_vivo_human: "ex_vivo_human";
353
- clinical: "clinical";
354
- }>>>;
355
653
  }, z.core.$strip>;
654
+ dropped_count: z.ZodOptional<z.ZodNumber>;
356
655
  inference_path: z.ZodOptional<z.ZodString>;
357
656
  truncated: z.ZodOptional<z.ZodBoolean>;
358
657
  }, z.core.$strip>, z.ZodObject<{
@@ -362,18 +661,215 @@ export declare const Phase4OutputSchema: z.ZodObject<{
362
661
  source: z.ZodOptional<z.ZodString>;
363
662
  }, z.core.$strip>>;
364
663
  inference_path: z.ZodOptional<z.ZodString>;
664
+ }, z.core.$strip>, z.ZodObject<{
665
+ coverage: z.ZodLiteral<"filtered">;
666
+ filter: z.ZodString;
667
+ dropped_count: z.ZodNumber;
668
+ inference_path: z.ZodOptional<z.ZodString>;
365
669
  }, z.core.$strip>, z.ZodObject<{
366
670
  coverage: z.ZodLiteral<"not_loaded">;
367
671
  reason: z.ZodOptional<z.ZodString>;
368
672
  }, z.core.$strip>], "coverage">;
369
- additional_evidence: z.ZodDiscriminatedUnion<[z.ZodObject<{
673
+ failed_trials: z.ZodDiscriminatedUnion<[z.ZodObject<{
370
674
  coverage: z.ZodLiteral<"available">;
371
675
  data: z.ZodObject<{
372
676
  rows: z.ZodArray<z.ZodObject<{
373
- predicate: z.ZodString;
677
+ nct_id: z.ZodString;
678
+ title: z.ZodString;
679
+ why_stopped: z.ZodString;
680
+ classifier: z.ZodEnum<{
681
+ rules: "rules";
682
+ llm: "llm";
683
+ }>;
684
+ failure_category: z.ZodDiscriminatedUnion<[z.ZodObject<{
685
+ category: z.ZodLiteral<"safety">;
686
+ safety_evidence_excerpt: z.ZodString;
687
+ }, z.core.$strip>, z.ZodObject<{
688
+ category: z.ZodLiteral<"strategic">;
689
+ category_evidence_excerpt: z.ZodString;
690
+ }, z.core.$strip>, z.ZodObject<{
691
+ category: z.ZodLiteral<"operational">;
692
+ category_evidence_excerpt: z.ZodString;
693
+ }, z.core.$strip>, z.ZodObject<{
694
+ category: z.ZodLiteral<"efficacy">;
695
+ category_evidence_excerpt: z.ZodString;
696
+ }, z.core.$strip>], "category">;
697
+ attribution: z.ZodObject<{
698
+ relationship: z.ZodEnum<{
699
+ unknown: "unknown";
700
+ related_family_target: "related_family_target";
701
+ condition_only: "condition_only";
702
+ direct_modulator: "direct_modulator";
703
+ class_modulator: "class_modulator";
704
+ target_biomarker: "target_biomarker";
705
+ pathway_biomarker: "pathway_biomarker";
706
+ unrelated: "unrelated";
707
+ }>;
708
+ evidence_role: z.ZodEnum<{
709
+ supports_target: "supports_target";
710
+ contextual: "contextual";
711
+ excluded: "excluded";
712
+ }>;
713
+ basis: z.ZodArray<z.ZodObject<{
714
+ kind: z.ZodEnum<{
715
+ mechanism_target_match: "mechanism_target_match";
716
+ known_class_drug: "known_class_drug";
717
+ therapeutic_program_match: "therapeutic_program_match";
718
+ related_family_target: "related_family_target";
719
+ biomarker_endpoint: "biomarker_endpoint";
720
+ condition_only: "condition_only";
721
+ text_match: "text_match";
722
+ manual: "manual";
723
+ }>;
724
+ source: z.ZodString;
725
+ excerpt: z.ZodOptional<z.ZodString>;
726
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
727
+ }, z.core.$strip>>;
728
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
729
+ name: z.ZodString;
730
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
731
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
732
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
733
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
734
+ resolver_source: z.ZodString;
735
+ }, z.core.$strip>>>;
736
+ exclusion_reason: z.ZodOptional<z.ZodString>;
737
+ }, z.core.$strip>;
738
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
739
+ }, z.core.$strip>>;
740
+ excluded_rows: z.ZodDefault<z.ZodArray<z.ZodObject<{
741
+ nct_id: z.ZodString;
742
+ title: z.ZodString;
743
+ why_stopped: z.ZodString;
744
+ classifier: z.ZodEnum<{
745
+ rules: "rules";
746
+ llm: "llm";
747
+ }>;
748
+ failure_category: z.ZodDiscriminatedUnion<[z.ZodObject<{
749
+ category: z.ZodLiteral<"safety">;
750
+ safety_evidence_excerpt: z.ZodString;
751
+ }, z.core.$strip>, z.ZodObject<{
752
+ category: z.ZodLiteral<"strategic">;
753
+ category_evidence_excerpt: z.ZodString;
754
+ }, z.core.$strip>, z.ZodObject<{
755
+ category: z.ZodLiteral<"operational">;
756
+ category_evidence_excerpt: z.ZodString;
757
+ }, z.core.$strip>, z.ZodObject<{
758
+ category: z.ZodLiteral<"efficacy">;
759
+ category_evidence_excerpt: z.ZodString;
760
+ }, z.core.$strip>], "category">;
761
+ attribution: z.ZodObject<{
762
+ relationship: z.ZodEnum<{
763
+ unknown: "unknown";
764
+ related_family_target: "related_family_target";
765
+ condition_only: "condition_only";
766
+ direct_modulator: "direct_modulator";
767
+ class_modulator: "class_modulator";
768
+ target_biomarker: "target_biomarker";
769
+ pathway_biomarker: "pathway_biomarker";
770
+ unrelated: "unrelated";
771
+ }>;
772
+ evidence_role: z.ZodEnum<{
773
+ supports_target: "supports_target";
774
+ contextual: "contextual";
775
+ excluded: "excluded";
776
+ }>;
777
+ basis: z.ZodArray<z.ZodObject<{
778
+ kind: z.ZodEnum<{
779
+ mechanism_target_match: "mechanism_target_match";
780
+ known_class_drug: "known_class_drug";
781
+ therapeutic_program_match: "therapeutic_program_match";
782
+ related_family_target: "related_family_target";
783
+ biomarker_endpoint: "biomarker_endpoint";
784
+ condition_only: "condition_only";
785
+ text_match: "text_match";
786
+ manual: "manual";
787
+ }>;
788
+ source: z.ZodString;
789
+ excerpt: z.ZodOptional<z.ZodString>;
790
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
791
+ }, z.core.$strip>>;
792
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
793
+ name: z.ZodString;
794
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
795
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
796
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
797
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
798
+ resolver_source: z.ZodString;
799
+ }, z.core.$strip>>>;
800
+ exclusion_reason: z.ZodOptional<z.ZodString>;
801
+ }, z.core.$strip>;
802
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
803
+ }, z.core.$strip>>>;
804
+ }, z.core.$strip>;
805
+ dropped_count: z.ZodOptional<z.ZodNumber>;
806
+ inference_path: z.ZodOptional<z.ZodString>;
807
+ truncated: z.ZodOptional<z.ZodBoolean>;
808
+ }, z.core.$strip>, z.ZodObject<{
809
+ coverage: z.ZodLiteral<"queried_no_data">;
810
+ error: z.ZodOptional<z.ZodObject<{
811
+ message: z.ZodString;
812
+ source: z.ZodOptional<z.ZodString>;
813
+ }, z.core.$strip>>;
814
+ inference_path: z.ZodOptional<z.ZodString>;
815
+ }, z.core.$strip>, z.ZodObject<{
816
+ coverage: z.ZodLiteral<"filtered">;
817
+ filter: z.ZodString;
818
+ dropped_count: z.ZodNumber;
819
+ inference_path: z.ZodOptional<z.ZodString>;
820
+ }, z.core.$strip>, z.ZodObject<{
821
+ coverage: z.ZodLiteral<"not_loaded">;
822
+ reason: z.ZodOptional<z.ZodString>;
823
+ }, z.core.$strip>], "coverage">;
824
+ benchmarks: z.ZodObject<{
825
+ therapeutic_area: z.ZodNullable<z.ZodString>;
826
+ fallback_to_all_areas: z.ZodBoolean;
827
+ phase_transitions: z.ZodRecord<z.ZodString, z.ZodNumber>;
828
+ likelihood_of_approval: z.ZodNullable<z.ZodNumber>;
829
+ source_attribution: z.ZodString;
830
+ }, z.core.$strip>;
831
+ }, z.core.$strip>;
832
+ safety_profile: z.ZodObject<{
833
+ organ_rollup: z.ZodDiscriminatedUnion<[z.ZodObject<{
834
+ coverage: z.ZodLiteral<"available">;
835
+ data: z.ZodObject<{
836
+ rows: z.ZodArray<z.ZodObject<{
837
+ organ: z.ZodEnum<{
838
+ hematologic: "hematologic";
839
+ metabolic: "metabolic";
840
+ immune: "immune";
841
+ hepatic: "hepatic";
842
+ musculoskeletal: "musculoskeletal";
843
+ cns: "cns";
844
+ renal: "renal";
845
+ reproductive: "reproductive";
846
+ respiratory: "respiratory";
847
+ cardiac: "cardiac";
848
+ vascular: "vascular";
849
+ pns: "pns";
850
+ gi: "gi";
851
+ pancreas: "pancreas";
852
+ endocrine_thyroid: "endocrine_thyroid";
853
+ dermatologic: "dermatologic";
854
+ ocular: "ocular";
855
+ oncology: "oncology";
856
+ }>;
857
+ risk_level: z.ZodEnum<{
858
+ high: "high";
859
+ medium: "medium";
860
+ low: "low";
861
+ }>;
862
+ signal_type_count: z.ZodNumber;
863
+ signals: z.ZodObject<{
864
+ chembl_polypharm_count: z.ZodNumber;
865
+ faers_count: z.ZodNumber;
866
+ trial_ae_count: z.ZodNumber;
867
+ class_liability_present: z.ZodBoolean;
868
+ }, z.core.$strip>;
374
869
  evidence: z.ZodArray<z.ZodObject<{
375
870
  pmid: z.ZodOptional<z.ZodString>;
376
871
  doi: z.ZodOptional<z.ZodString>;
872
+ accession: z.ZodOptional<z.ZodString>;
377
873
  source: z.ZodString;
378
874
  predicate: z.ZodOptional<z.ZodString>;
379
875
  score: z.ZodOptional<z.ZodNumber>;
@@ -390,8 +886,8 @@ export declare const Phase4OutputSchema: z.ZodObject<{
390
886
  }, z.core.$strip>>;
391
887
  }, z.core.$strip>>;
392
888
  }, z.core.$strip>>;
393
- score_floor: z.ZodNumber;
394
889
  }, z.core.$strip>;
890
+ dropped_count: z.ZodOptional<z.ZodNumber>;
395
891
  inference_path: z.ZodOptional<z.ZodString>;
396
892
  truncated: z.ZodOptional<z.ZodBoolean>;
397
893
  }, z.core.$strip>, z.ZodObject<{
@@ -401,52 +897,53 @@ export declare const Phase4OutputSchema: z.ZodObject<{
401
897
  source: z.ZodOptional<z.ZodString>;
402
898
  }, z.core.$strip>>;
403
899
  inference_path: z.ZodOptional<z.ZodString>;
900
+ }, z.core.$strip>, z.ZodObject<{
901
+ coverage: z.ZodLiteral<"filtered">;
902
+ filter: z.ZodString;
903
+ dropped_count: z.ZodNumber;
904
+ inference_path: z.ZodOptional<z.ZodString>;
404
905
  }, z.core.$strip>, z.ZodObject<{
405
906
  coverage: z.ZodLiteral<"not_loaded">;
406
907
  reason: z.ZodOptional<z.ZodString>;
407
908
  }, z.core.$strip>], "coverage">;
408
- discovery_trials: z.ZodDiscriminatedUnion<[z.ZodObject<{
909
+ faers: z.ZodDiscriminatedUnion<[z.ZodObject<{
409
910
  coverage: z.ZodLiteral<"available">;
410
911
  data: z.ZodObject<{
411
- rows: z.ZodArray<z.ZodObject<{
412
- nct_id: z.ZodString;
413
- title: z.ZodString;
414
- phase: z.ZodOptional<z.ZodNullable<z.ZodString>>;
415
- status: z.ZodOptional<z.ZodString>;
416
- conditions: z.ZodArray<z.ZodString>;
417
- start_date: z.ZodOptional<z.ZodString>;
418
- completion_date: z.ZodOptional<z.ZodString>;
419
- match_confidence: z.ZodEnum<{
420
- high: "high";
421
- medium: "medium";
422
- low: "low";
912
+ total_reports: z.ZodNumber;
913
+ seriousness: z.ZodDiscriminatedUnion<[z.ZodObject<{
914
+ coverage: z.ZodLiteral<"available">;
915
+ total_reports: z.ZodNumber;
916
+ by_seriousness: z.ZodObject<{
917
+ death: z.ZodNumber;
918
+ life_threatening: z.ZodNumber;
919
+ hospitalization: z.ZodNumber;
920
+ disabling: z.ZodNumber;
921
+ other_serious: z.ZodNumber;
922
+ congenital_anomaly: z.ZodNumber;
923
+ }, z.core.$strip>;
924
+ fatal_report_count: z.ZodNumber;
925
+ }, z.core.$strip>, z.ZodObject<{
926
+ coverage: z.ZodLiteral<"queried_no_data">;
927
+ total_reports: z.ZodNumber;
928
+ }, z.core.$strip>], "coverage">;
929
+ top_signals: z.ZodArray<z.ZodObject<{
930
+ meddra_term: z.ZodString;
931
+ organ: z.ZodOptional<z.ZodString>;
932
+ report_count: z.ZodNumber;
933
+ proportional_reporting_ratio: z.ZodOptional<z.ZodNumber>;
934
+ }, z.core.$strip>>;
935
+ per_modulator: z.ZodArray<z.ZodObject<{
936
+ modulator: z.ZodString;
937
+ modulator_id: z.ZodNullable<z.ZodString>;
938
+ report_count: z.ZodNumber;
939
+ coverage: z.ZodEnum<{
940
+ available: "available";
941
+ queried_no_data: "queried_no_data";
942
+ not_loaded: "not_loaded";
423
943
  }>;
424
- relevance_basis: z.ZodDiscriminatedUnion<[z.ZodObject<{
425
- kind: z.ZodLiteral<"drug_in_class_match">;
426
- drug_id: z.ZodString;
427
- matched_term: z.ZodOptional<z.ZodString>;
428
- }, z.core.$strip>, z.ZodObject<{
429
- kind: z.ZodLiteral<"title_keyword">;
430
- matched_term: z.ZodString;
431
- }, z.core.$strip>, z.ZodObject<{
432
- kind: z.ZodLiteral<"condition_match">;
433
- matched_term: z.ZodOptional<z.ZodString>;
434
- }, z.core.$strip>, z.ZodObject<{
435
- kind: z.ZodLiteral<"manual">;
436
- }, z.core.$strip>], "kind">;
437
944
  }, z.core.$strip>>;
438
- related_target_trials: z.ZodOptional<z.ZodArray<z.ZodObject<{
439
- nct_id: z.ZodString;
440
- title: z.ZodString;
441
- phase: z.ZodNullable<z.ZodString>;
442
- status: z.ZodString;
443
- conditions: z.ZodArray<z.ZodString>;
444
- start_date: z.ZodNullable<z.ZodString>;
445
- completion_date: z.ZodNullable<z.ZodString>;
446
- match_confidence: z.ZodLiteral<"off_target">;
447
- }, z.core.$strip>>>;
448
- related_receptor: z.ZodOptional<z.ZodString>;
449
945
  }, z.core.$strip>;
946
+ dropped_count: z.ZodOptional<z.ZodNumber>;
450
947
  inference_path: z.ZodOptional<z.ZodString>;
451
948
  truncated: z.ZodOptional<z.ZodBoolean>;
452
949
  }, z.core.$strip>, z.ZodObject<{
@@ -456,47 +953,40 @@ export declare const Phase4OutputSchema: z.ZodObject<{
456
953
  source: z.ZodOptional<z.ZodString>;
457
954
  }, z.core.$strip>>;
458
955
  inference_path: z.ZodOptional<z.ZodString>;
956
+ }, z.core.$strip>, z.ZodObject<{
957
+ coverage: z.ZodLiteral<"filtered">;
958
+ filter: z.ZodString;
959
+ dropped_count: z.ZodNumber;
960
+ inference_path: z.ZodOptional<z.ZodString>;
459
961
  }, z.core.$strip>, z.ZodObject<{
460
962
  coverage: z.ZodLiteral<"not_loaded">;
461
963
  reason: z.ZodOptional<z.ZodString>;
462
964
  }, z.core.$strip>], "coverage">;
463
- synthesis_diagnostics: z.ZodDiscriminatedUnion<[z.ZodObject<{
965
+ trial_aes: z.ZodDiscriminatedUnion<[z.ZodObject<{
464
966
  coverage: z.ZodLiteral<"available">;
465
967
  data: z.ZodObject<{
466
- rows: z.ZodArray<z.ZodObject<{
467
- step_id: z.ZodEnum<{
468
- "liability-bullets": "liability-bullets";
469
- "safety-flags-trail": "safety-flags-trail";
470
- "translational-commentary": "translational-commentary";
471
- "dossier-recommendation": "dossier-recommendation";
472
- }>;
473
- model_id: z.ZodString;
474
- attempt_count: z.ZodNumber;
475
- retry_critique: z.ZodNullable<z.ZodString>;
476
- output_chars: z.ZodNumber;
477
- probe_verdict: z.ZodEnum<{
478
- skipped: "skipped";
479
- pass: "pass";
480
- "fail-length": "fail-length";
481
- "fail-section-references": "fail-section-references";
482
- "fail-key-strengths-risks": "fail-key-strengths-risks";
483
- "fail-source-references": "fail-source-references";
484
- "fail-numeric-claim": "fail-numeric-claim";
485
- "fail-voice": "fail-voice";
486
- relaxed: "relaxed";
487
- }>;
488
- final_coverage: z.ZodEnum<{
489
- available: "available";
490
- queried_no_data: "queried_no_data";
491
- }>;
492
- error_kind: z.ZodOptional<z.ZodNullable<z.ZodEnum<{
493
- "synthesis-too-shallow": "synthesis-too-shallow";
494
- "synthesis-unavailable": "synthesis-unavailable";
495
- "voice-violation": "voice-violation";
496
- }>>>;
497
- error_message: z.ZodOptional<z.ZodNullable<z.ZodString>>;
968
+ serious: z.ZodArray<z.ZodObject<{
969
+ term: z.ZodString;
970
+ incidence_pct: z.ZodNumber;
971
+ organ: z.ZodOptional<z.ZodString>;
972
+ nct_ids: z.ZodArray<z.ZodString>;
973
+ }, z.core.$strip>>;
974
+ non_serious: z.ZodArray<z.ZodObject<{
975
+ term: z.ZodString;
976
+ incidence_pct: z.ZodNumber;
977
+ organ: z.ZodOptional<z.ZodString>;
978
+ nct_ids: z.ZodArray<z.ZodString>;
979
+ }, z.core.$strip>>;
980
+ non_serious_floor_pct: z.ZodDefault<z.ZodNumber>;
981
+ dropped_uninformative_count: z.ZodOptional<z.ZodNumber>;
982
+ coverage_qualifier: z.ZodOptional<z.ZodObject<{
983
+ trials_queried: z.ZodNumber;
984
+ trials_with_ae_data: z.ZodNumber;
985
+ serious_floor_applied: z.ZodOptional<z.ZodNumber>;
986
+ non_serious_floor_pct_applied: z.ZodOptional<z.ZodNumber>;
498
987
  }, z.core.$strip>>;
499
988
  }, z.core.$strip>;
989
+ dropped_count: z.ZodOptional<z.ZodNumber>;
500
990
  inference_path: z.ZodOptional<z.ZodString>;
501
991
  truncated: z.ZodOptional<z.ZodBoolean>;
502
992
  }, z.core.$strip>, z.ZodObject<{
@@ -506,231 +996,163 @@ export declare const Phase4OutputSchema: z.ZodObject<{
506
996
  source: z.ZodOptional<z.ZodString>;
507
997
  }, z.core.$strip>>;
508
998
  inference_path: z.ZodOptional<z.ZodString>;
999
+ }, z.core.$strip>, z.ZodObject<{
1000
+ coverage: z.ZodLiteral<"filtered">;
1001
+ filter: z.ZodString;
1002
+ dropped_count: z.ZodNumber;
1003
+ inference_path: z.ZodOptional<z.ZodString>;
509
1004
  }, z.core.$strip>, z.ZodObject<{
510
1005
  coverage: z.ZodLiteral<"not_loaded">;
511
1006
  reason: z.ZodOptional<z.ZodString>;
512
1007
  }, z.core.$strip>], "coverage">;
513
- recommendation_audit: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
1008
+ off_target_panel: z.ZodDiscriminatedUnion<[z.ZodObject<{
514
1009
  coverage: z.ZodLiteral<"available">;
515
1010
  data: z.ZodObject<{
516
- citations_total: z.ZodNumber;
517
- citations_unresolved: z.ZodArray<z.ZodUnion<readonly [z.ZodObject<{
518
- surface: z.ZodEnum<{
519
- rationale: "rationale";
520
- key_strengths: "key_strengths";
521
- key_risks: "key_risks";
522
- modality_choice: "modality_choice";
523
- }>;
524
- path: z.ZodString;
525
- excerpt: z.ZodString;
526
- }, z.core.$strip>, z.ZodObject<{
527
- surface: z.ZodLiteral<"external_missing">;
528
- id: z.ZodString;
529
- excerpt: z.ZodString;
530
- }, z.core.$strip>, z.ZodObject<{
531
- surface: z.ZodLiteral<"organ_claim_without_probe_pass">;
532
- excerpt: z.ZodString;
533
- bullet_category: z.ZodString;
534
- }, z.core.$strip>, z.ZodObject<{
535
- surface: z.ZodLiteral<"nct_wrong_class">;
536
- id: z.ZodString;
537
- excerpt: z.ZodString;
538
- }, z.core.$strip>, z.ZodObject<{
539
- surface: z.ZodLiteral<"pmid_not_in_key_papers">;
540
- id: z.ZodString;
541
- excerpt: z.ZodString;
542
- }, z.core.$strip>, z.ZodObject<{
543
- surface: z.ZodLiteral<"direction_mismatch">;
544
- pmid: z.ZodString;
545
- excerpt: z.ZodString;
546
- paper_conclusion_direction: z.ZodOptional<z.ZodEnum<{
547
- supports: "supports";
548
- contradicts: "contradicts";
549
- ambiguous: "ambiguous";
1011
+ rows: z.ZodArray<z.ZodObject<{
1012
+ off_target_id: z.ZodNullable<z.ZodString>;
1013
+ off_target_name: z.ZodString;
1014
+ target_class: z.ZodOptional<z.ZodString>;
1015
+ pchembl: z.ZodNumber;
1016
+ is_safety_panel_target: z.ZodBoolean;
1017
+ organ_system: z.ZodNullable<z.ZodEnum<{
1018
+ hematologic: "hematologic";
1019
+ metabolic: "metabolic";
1020
+ immune: "immune";
1021
+ hepatic: "hepatic";
1022
+ musculoskeletal: "musculoskeletal";
1023
+ cns: "cns";
1024
+ renal: "renal";
1025
+ reproductive: "reproductive";
1026
+ respiratory: "respiratory";
1027
+ cardiac: "cardiac";
1028
+ vascular: "vascular";
1029
+ pns: "pns";
1030
+ gi: "gi";
1031
+ pancreas: "pancreas";
1032
+ endocrine_thyroid: "endocrine_thyroid";
1033
+ dermatologic: "dermatologic";
1034
+ ocular: "ocular";
1035
+ oncology: "oncology";
550
1036
  }>>;
551
- }, z.core.$strip>, z.ZodObject<{
552
- surface: z.ZodLiteral<"abstract_unavailable">;
553
- pmid: z.ZodString;
554
- excerpt: z.ZodString;
555
- }, z.core.$strip>, z.ZodObject<{
556
- surface: z.ZodLiteral<"off_topic_citation">;
557
- pmid: z.ZodString;
558
- excerpt: z.ZodString;
559
- }, z.core.$strip>]>>;
560
- non_dossier_citations: z.ZodArray<z.ZodObject<{
561
- token: z.ZodString;
562
- source: z.ZodString;
563
- }, z.core.$strip>>;
564
- }, z.core.$strip>;
565
- inference_path: z.ZodOptional<z.ZodString>;
566
- truncated: z.ZodOptional<z.ZodBoolean>;
567
- }, z.core.$strip>, z.ZodObject<{
568
- coverage: z.ZodLiteral<"queried_no_data">;
569
- error: z.ZodOptional<z.ZodObject<{
570
- message: z.ZodString;
571
- source: z.ZodOptional<z.ZodString>;
572
- }, z.core.$strip>>;
573
- inference_path: z.ZodOptional<z.ZodString>;
574
- }, z.core.$strip>, z.ZodObject<{
575
- coverage: z.ZodLiteral<"not_loaded">;
576
- reason: z.ZodOptional<z.ZodString>;
577
- }, z.core.$strip>], "coverage">>;
578
- }, z.core.$strip>;
579
- executive_recommendation: z.ZodDiscriminatedUnion<[z.ZodObject<{
580
- coverage: z.ZodLiteral<"available">;
581
- data: z.ZodObject<{
582
- disposition: z.ZodEnum<{
583
- pursue: "pursue";
584
- conditional: "conditional";
585
- de_prioritize: "de_prioritize";
586
- insufficient_evidence: "insufficient_evidence";
587
- }>;
588
- confidence: z.ZodEnum<{
589
- high: "high";
590
- medium: "medium";
591
- low: "low";
592
- }>;
593
- rationale: z.ZodString;
594
- key_strengths: z.ZodDefault<z.ZodArray<z.ZodString>>;
595
- key_risks: z.ZodDefault<z.ZodArray<z.ZodString>>;
596
- key_risks_dropped: z.ZodOptional<z.ZodArray<z.ZodObject<{
597
- text: z.ZodString;
598
- reason: z.ZodString;
599
- cited_pmid: z.ZodOptional<z.ZodString>;
600
- }, z.core.$strip>>>;
601
- key_risks_downgraded: z.ZodOptional<z.ZodArray<z.ZodObject<{
602
- bullet_index: z.ZodNumber;
603
- reason: z.ZodString;
604
- cited_pmid: z.ZodOptional<z.ZodString>;
605
- }, z.core.$strip>>>;
606
- modality_choice: z.ZodObject<{
607
- modality: z.ZodString;
608
- rationale: z.ZodString;
609
- }, z.core.$strip>;
610
- coverage_qualifier: z.ZodObject<{
611
- sections_consulted: z.ZodDefault<z.ZodArray<z.ZodString>>;
612
- sections_unavailable: z.ZodDefault<z.ZodArray<z.ZodString>>;
613
- note: z.ZodString;
614
- unverified_bullets: z.ZodOptional<z.ZodArray<z.ZodObject<{
615
- text: z.ZodString;
616
- bullet_category: z.ZodString;
617
- surface: z.ZodLiteral<"organ_claim_without_probe_pass">;
618
- }, z.core.$strip>>>;
619
- }, z.core.$strip>;
620
- }, z.core.$strip>;
621
- inference_path: z.ZodOptional<z.ZodString>;
622
- truncated: z.ZodOptional<z.ZodBoolean>;
623
- }, z.core.$strip>, z.ZodObject<{
624
- coverage: z.ZodLiteral<"queried_no_data">;
625
- error: z.ZodOptional<z.ZodObject<{
626
- message: z.ZodString;
627
- source: z.ZodOptional<z.ZodString>;
628
- }, z.core.$strip>>;
629
- inference_path: z.ZodOptional<z.ZodString>;
630
- }, z.core.$strip>, z.ZodObject<{
631
- coverage: z.ZodLiteral<"not_loaded">;
632
- reason: z.ZodOptional<z.ZodString>;
633
- }, z.core.$strip>], "coverage">;
634
- entity: z.ZodObject<{
635
- canonicalId: z.ZodString;
636
- symbol: z.ZodString;
637
- displayName: z.ZodString;
638
- entityType: z.ZodEnum<{
639
- gene: "gene";
640
- rna: "rna";
641
- protein: "protein";
642
- complex: "complex";
643
- }>;
644
- ontology: z.ZodString;
645
- identifiers: z.ZodObject<{
646
- hgnc: z.ZodOptional<z.ZodString>;
647
- ensembl: z.ZodOptional<z.ZodString>;
648
- uniprot: z.ZodOptional<z.ZodString>;
649
- chembl: z.ZodOptional<z.ZodString>;
650
- ncbiGene: z.ZodOptional<z.ZodString>;
651
- }, z.core.$strip>;
652
- synonyms: z.ZodDefault<z.ZodArray<z.ZodString>>;
653
- proteinFamily: z.ZodOptional<z.ZodString>;
654
- }, z.core.$strip>;
655
- indications: z.ZodDiscriminatedUnion<[z.ZodObject<{
656
- coverage: z.ZodLiteral<"available">;
657
- data: z.ZodObject<{
658
- rows: z.ZodArray<z.ZodObject<{
659
- disease_id: z.ZodString;
660
- disease_name: z.ZodString;
661
- composite_score: z.ZodNumber;
662
- composite_score_breakdown: z.ZodOptional<z.ZodObject<{
663
- base: z.ZodNumber;
664
- source_bonuses: z.ZodRecord<z.ZodString, z.ZodNumber>;
665
- paper_depth: z.ZodNumber;
666
- }, z.core.$strip>>;
667
- evidence_score: z.ZodNumber;
668
- source_count: z.ZodNumber;
669
- unique_paper_count: z.ZodNumber;
670
- sources: z.ZodArray<z.ZodString>;
671
- evidence: z.ZodArray<z.ZodObject<{
672
- pmid: z.ZodOptional<z.ZodString>;
673
- doi: z.ZodOptional<z.ZodString>;
674
- source: z.ZodString;
675
- predicate: z.ZodOptional<z.ZodString>;
676
- score: z.ZodOptional<z.ZodNumber>;
677
- strength: z.ZodOptional<z.ZodString>;
678
- is_human: z.ZodOptional<z.ZodBoolean>;
679
- is_clinical: z.ZodOptional<z.ZodBoolean>;
680
- excerpt: z.ZodOptional<z.ZodString>;
681
- metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
682
- regulatory_reference: z.ZodOptional<z.ZodObject<{
683
- document: z.ZodString;
684
- section: z.ZodOptional<z.ZodString>;
685
- doc_id: z.ZodOptional<z.ZodString>;
686
- doc_url: z.ZodOptional<z.ZodString>;
687
- }, z.core.$strip>>;
688
- }, z.core.$strip>>;
689
- }, z.core.$strip>>;
690
- excluded_unsupported_count: z.ZodOptional<z.ZodNumber>;
691
- unsupported_associations: z.ZodOptional<z.ZodArray<z.ZodObject<{
692
- disease_id: z.ZodString;
693
- disease_name: z.ZodString;
694
- }, z.core.$strip>>>;
695
- }, z.core.$strip>;
696
- inference_path: z.ZodOptional<z.ZodString>;
697
- truncated: z.ZodOptional<z.ZodBoolean>;
698
- }, z.core.$strip>, z.ZodObject<{
699
- coverage: z.ZodLiteral<"queried_no_data">;
700
- error: z.ZodOptional<z.ZodObject<{
701
- message: z.ZodString;
702
- source: z.ZodOptional<z.ZodString>;
703
- }, z.core.$strip>>;
704
- inference_path: z.ZodOptional<z.ZodString>;
705
- }, z.core.$strip>, z.ZodObject<{
706
- coverage: z.ZodLiteral<"not_loaded">;
707
- reason: z.ZodOptional<z.ZodString>;
708
- }, z.core.$strip>], "coverage">;
709
- clinical_development: z.ZodObject<{
710
- trials: z.ZodDiscriminatedUnion<[z.ZodObject<{
711
- coverage: z.ZodLiteral<"available">;
712
- data: z.ZodObject<{
713
- rows: z.ZodArray<z.ZodObject<{
714
- nct_id: z.ZodString;
715
- title: z.ZodString;
716
- phase: z.ZodNullable<z.ZodString>;
717
- status: z.ZodString;
718
- conditions: z.ZodArray<z.ZodString>;
719
- start_date: z.ZodNullable<z.ZodString>;
720
- completion_date: z.ZodNullable<z.ZodString>;
721
- match_confidence: z.ZodEnum<{
722
- high: "high";
723
- medium: "medium";
724
- low: "low";
725
- off_target: "off_target";
726
- }>;
727
- }, z.core.$strip>>;
728
- selection_criteria: z.ZodOptional<z.ZodObject<{
729
- derived_from: z.ZodOptional<z.ZodString>;
730
- min_confidence: z.ZodOptional<z.ZodString>;
731
- excluded_off_target_count: z.ZodOptional<z.ZodNumber>;
1037
+ clinical_consequence: z.ZodNullable<z.ZodString>;
1038
+ selectivity: z.ZodUnion<readonly [z.ZodObject<{
1039
+ vs_primary_potency: z.ZodObject<{
1040
+ primary_pchembl_used: z.ZodNumber;
1041
+ primary_source: z.ZodEnum<{
1042
+ chembl_target_drug_indication: "chembl_target_drug_indication";
1043
+ literature_curated: "literature_curated";
1044
+ }>;
1045
+ fold: z.ZodNumber;
1046
+ log_units: z.ZodNumber;
1047
+ }, z.core.$strip>;
1048
+ }, z.core.$strip>, z.ZodObject<{
1049
+ selectivity_unknown: z.ZodLiteral<true>;
1050
+ reason: z.ZodString;
1051
+ }, z.core.$strip>]>;
1052
+ selectivity_window_below_threshold: z.ZodBoolean;
1053
+ metadata: z.ZodOptional<z.ZodObject<{
1054
+ merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
1055
+ }, z.core.$strip>>;
1056
+ relationship: z.ZodLiteral<"off_target">;
1057
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1058
+ state: z.ZodLiteral<"scored">;
1059
+ evidence: z.ZodArray<z.ZodObject<{
1060
+ pmid: z.ZodOptional<z.ZodString>;
1061
+ doi: z.ZodOptional<z.ZodString>;
1062
+ accession: z.ZodOptional<z.ZodString>;
1063
+ source: z.ZodString;
1064
+ predicate: z.ZodOptional<z.ZodString>;
1065
+ score: z.ZodOptional<z.ZodNumber>;
1066
+ strength: z.ZodOptional<z.ZodString>;
1067
+ is_human: z.ZodOptional<z.ZodBoolean>;
1068
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1069
+ excerpt: z.ZodOptional<z.ZodString>;
1070
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1071
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1072
+ document: z.ZodString;
1073
+ section: z.ZodOptional<z.ZodString>;
1074
+ doc_id: z.ZodOptional<z.ZodString>;
1075
+ doc_url: z.ZodOptional<z.ZodString>;
1076
+ }, z.core.$strip>>;
1077
+ }, z.core.$strip>>;
1078
+ }, z.core.$strip>, z.ZodObject<{
1079
+ state: z.ZodLiteral<"unknown">;
1080
+ reason: z.ZodString;
1081
+ }, z.core.$strip>], "state">;
1082
+ }, z.core.$strip>>;
1083
+ excluded_rows: z.ZodArray<z.ZodObject<{
1084
+ off_target_id: z.ZodNullable<z.ZodString>;
1085
+ off_target_name: z.ZodString;
1086
+ target_class: z.ZodOptional<z.ZodString>;
1087
+ pchembl: z.ZodNumber;
1088
+ is_safety_panel_target: z.ZodBoolean;
1089
+ organ_system: z.ZodNullable<z.ZodEnum<{
1090
+ hematologic: "hematologic";
1091
+ metabolic: "metabolic";
1092
+ immune: "immune";
1093
+ hepatic: "hepatic";
1094
+ musculoskeletal: "musculoskeletal";
1095
+ cns: "cns";
1096
+ renal: "renal";
1097
+ reproductive: "reproductive";
1098
+ respiratory: "respiratory";
1099
+ cardiac: "cardiac";
1100
+ vascular: "vascular";
1101
+ pns: "pns";
1102
+ gi: "gi";
1103
+ pancreas: "pancreas";
1104
+ endocrine_thyroid: "endocrine_thyroid";
1105
+ dermatologic: "dermatologic";
1106
+ ocular: "ocular";
1107
+ oncology: "oncology";
1108
+ }>>;
1109
+ clinical_consequence: z.ZodNullable<z.ZodString>;
1110
+ selectivity: z.ZodUnion<readonly [z.ZodObject<{
1111
+ vs_primary_potency: z.ZodObject<{
1112
+ primary_pchembl_used: z.ZodNumber;
1113
+ primary_source: z.ZodEnum<{
1114
+ chembl_target_drug_indication: "chembl_target_drug_indication";
1115
+ literature_curated: "literature_curated";
1116
+ }>;
1117
+ fold: z.ZodNumber;
1118
+ log_units: z.ZodNumber;
1119
+ }, z.core.$strip>;
1120
+ }, z.core.$strip>, z.ZodObject<{
1121
+ selectivity_unknown: z.ZodLiteral<true>;
1122
+ reason: z.ZodString;
1123
+ }, z.core.$strip>]>;
1124
+ selectivity_window_below_threshold: z.ZodBoolean;
1125
+ metadata: z.ZodOptional<z.ZodObject<{
1126
+ merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
1127
+ }, z.core.$strip>>;
1128
+ relationship: z.ZodEnum<{
1129
+ intended_co_target: "intended_co_target";
1130
+ on_target_self_hit: "on_target_self_hit";
1131
+ obligate_cofactor: "obligate_cofactor";
1132
+ }>;
1133
+ reason: z.ZodString;
1134
+ evidence: z.ZodArray<z.ZodObject<{
1135
+ pmid: z.ZodOptional<z.ZodString>;
1136
+ doi: z.ZodOptional<z.ZodString>;
1137
+ accession: z.ZodOptional<z.ZodString>;
1138
+ source: z.ZodString;
1139
+ predicate: z.ZodOptional<z.ZodString>;
1140
+ score: z.ZodOptional<z.ZodNumber>;
1141
+ strength: z.ZodOptional<z.ZodString>;
1142
+ is_human: z.ZodOptional<z.ZodBoolean>;
1143
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1144
+ excerpt: z.ZodOptional<z.ZodString>;
1145
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1146
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1147
+ document: z.ZodString;
1148
+ section: z.ZodOptional<z.ZodString>;
1149
+ doc_id: z.ZodOptional<z.ZodString>;
1150
+ doc_url: z.ZodOptional<z.ZodString>;
1151
+ }, z.core.$strip>>;
1152
+ }, z.core.$strip>>;
732
1153
  }, z.core.$strip>>;
733
1154
  }, z.core.$strip>;
1155
+ dropped_count: z.ZodOptional<z.ZodNumber>;
734
1156
  inference_path: z.ZodOptional<z.ZodString>;
735
1157
  truncated: z.ZodOptional<z.ZodBoolean>;
736
1158
  }, z.core.$strip>, z.ZodObject<{
@@ -740,64 +1162,83 @@ export declare const Phase4OutputSchema: z.ZodObject<{
740
1162
  source: z.ZodOptional<z.ZodString>;
741
1163
  }, z.core.$strip>>;
742
1164
  inference_path: z.ZodOptional<z.ZodString>;
1165
+ }, z.core.$strip>, z.ZodObject<{
1166
+ coverage: z.ZodLiteral<"filtered">;
1167
+ filter: z.ZodString;
1168
+ dropped_count: z.ZodNumber;
1169
+ inference_path: z.ZodOptional<z.ZodString>;
743
1170
  }, z.core.$strip>, z.ZodObject<{
744
1171
  coverage: z.ZodLiteral<"not_loaded">;
745
1172
  reason: z.ZodOptional<z.ZodString>;
746
1173
  }, z.core.$strip>], "coverage">;
747
- outcomes: z.ZodDiscriminatedUnion<[z.ZodObject<{
1174
+ failed_trials_safety_lens: z.ZodDiscriminatedUnion<[z.ZodObject<{
748
1175
  coverage: z.ZodLiteral<"available">;
749
1176
  data: z.ZodObject<{
750
1177
  rows: z.ZodArray<z.ZodObject<{
751
1178
  nct_id: z.ZodString;
752
- measure: z.ZodString;
753
- outcome_type: z.ZodEnum<{
754
- other: "other";
755
- primary: "primary";
756
- secondary: "secondary";
1179
+ title: z.ZodString;
1180
+ why_stopped: z.ZodString;
1181
+ classifier: z.ZodEnum<{
1182
+ rules: "rules";
1183
+ llm: "llm";
757
1184
  }>;
758
- description: z.ZodOptional<z.ZodString>;
759
- time_frame: z.ZodOptional<z.ZodString>;
760
- effect: z.ZodDiscriminatedUnion<[z.ZodObject<{
761
- kind: z.ZodLiteral<"quantitative">;
762
- value: z.ZodNumber;
763
- ci_low: z.ZodOptional<z.ZodNumber>;
764
- ci_high: z.ZodOptional<z.ZodNumber>;
765
- units: z.ZodString;
1185
+ failure_category: z.ZodDiscriminatedUnion<[z.ZodObject<{
1186
+ category: z.ZodLiteral<"safety">;
1187
+ safety_evidence_excerpt: z.ZodString;
766
1188
  }, z.core.$strip>, z.ZodObject<{
767
- kind: z.ZodLiteral<"qualitative">;
768
- direction: z.ZodEnum<{
769
- increase: "increase";
770
- decrease: "decrease";
771
- no_change: "no_change";
772
- }>;
773
- magnitude_label: z.ZodString;
1189
+ category: z.ZodLiteral<"strategic">;
1190
+ category_evidence_excerpt: z.ZodString;
774
1191
  }, z.core.$strip>, z.ZodObject<{
775
- kind: z.ZodLiteral<"not_extracted">;
776
- reason: z.ZodEnum<{
777
- ctgov_no_numeric_result: "ctgov_no_numeric_result";
778
- ctgov_no_result_groups: "ctgov_no_result_groups";
779
- parse_failure: "parse_failure";
1192
+ category: z.ZodLiteral<"operational">;
1193
+ category_evidence_excerpt: z.ZodString;
1194
+ }, z.core.$strip>, z.ZodObject<{
1195
+ category: z.ZodLiteral<"efficacy">;
1196
+ category_evidence_excerpt: z.ZodString;
1197
+ }, z.core.$strip>], "category">;
1198
+ attribution: z.ZodObject<{
1199
+ relationship: z.ZodEnum<{
1200
+ unknown: "unknown";
1201
+ related_family_target: "related_family_target";
1202
+ condition_only: "condition_only";
1203
+ direct_modulator: "direct_modulator";
1204
+ class_modulator: "class_modulator";
1205
+ target_biomarker: "target_biomarker";
1206
+ pathway_biomarker: "pathway_biomarker";
1207
+ unrelated: "unrelated";
780
1208
  }>;
781
- }, z.core.$strip>], "kind">;
1209
+ evidence_role: z.ZodEnum<{
1210
+ supports_target: "supports_target";
1211
+ contextual: "contextual";
1212
+ excluded: "excluded";
1213
+ }>;
1214
+ basis: z.ZodArray<z.ZodObject<{
1215
+ kind: z.ZodEnum<{
1216
+ mechanism_target_match: "mechanism_target_match";
1217
+ known_class_drug: "known_class_drug";
1218
+ therapeutic_program_match: "therapeutic_program_match";
1219
+ related_family_target: "related_family_target";
1220
+ biomarker_endpoint: "biomarker_endpoint";
1221
+ condition_only: "condition_only";
1222
+ text_match: "text_match";
1223
+ manual: "manual";
1224
+ }>;
1225
+ source: z.ZodString;
1226
+ excerpt: z.ZodOptional<z.ZodString>;
1227
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1228
+ }, z.core.$strip>>;
1229
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
1230
+ name: z.ZodString;
1231
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1232
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1233
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1234
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
1235
+ resolver_source: z.ZodString;
1236
+ }, z.core.$strip>>>;
1237
+ exclusion_reason: z.ZodOptional<z.ZodString>;
1238
+ }, z.core.$strip>;
1239
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
782
1240
  }, z.core.$strip>>;
783
- }, z.core.$strip>;
784
- inference_path: z.ZodOptional<z.ZodString>;
785
- truncated: z.ZodOptional<z.ZodBoolean>;
786
- }, z.core.$strip>, z.ZodObject<{
787
- coverage: z.ZodLiteral<"queried_no_data">;
788
- error: z.ZodOptional<z.ZodObject<{
789
- message: z.ZodString;
790
- source: z.ZodOptional<z.ZodString>;
791
- }, z.core.$strip>>;
792
- inference_path: z.ZodOptional<z.ZodString>;
793
- }, z.core.$strip>, z.ZodObject<{
794
- coverage: z.ZodLiteral<"not_loaded">;
795
- reason: z.ZodOptional<z.ZodString>;
796
- }, z.core.$strip>], "coverage">;
797
- failed_trials: z.ZodDiscriminatedUnion<[z.ZodObject<{
798
- coverage: z.ZodLiteral<"available">;
799
- data: z.ZodObject<{
800
- rows: z.ZodArray<z.ZodObject<{
1241
+ excluded_rows: z.ZodDefault<z.ZodArray<z.ZodObject<{
801
1242
  nct_id: z.ZodString;
802
1243
  title: z.ZodString;
803
1244
  why_stopped: z.ZodString;
@@ -818,8 +1259,51 @@ export declare const Phase4OutputSchema: z.ZodObject<{
818
1259
  category: z.ZodLiteral<"efficacy">;
819
1260
  category_evidence_excerpt: z.ZodString;
820
1261
  }, z.core.$strip>], "category">;
821
- }, z.core.$strip>>;
1262
+ attribution: z.ZodObject<{
1263
+ relationship: z.ZodEnum<{
1264
+ unknown: "unknown";
1265
+ related_family_target: "related_family_target";
1266
+ condition_only: "condition_only";
1267
+ direct_modulator: "direct_modulator";
1268
+ class_modulator: "class_modulator";
1269
+ target_biomarker: "target_biomarker";
1270
+ pathway_biomarker: "pathway_biomarker";
1271
+ unrelated: "unrelated";
1272
+ }>;
1273
+ evidence_role: z.ZodEnum<{
1274
+ supports_target: "supports_target";
1275
+ contextual: "contextual";
1276
+ excluded: "excluded";
1277
+ }>;
1278
+ basis: z.ZodArray<z.ZodObject<{
1279
+ kind: z.ZodEnum<{
1280
+ mechanism_target_match: "mechanism_target_match";
1281
+ known_class_drug: "known_class_drug";
1282
+ therapeutic_program_match: "therapeutic_program_match";
1283
+ related_family_target: "related_family_target";
1284
+ biomarker_endpoint: "biomarker_endpoint";
1285
+ condition_only: "condition_only";
1286
+ text_match: "text_match";
1287
+ manual: "manual";
1288
+ }>;
1289
+ source: z.ZodString;
1290
+ excerpt: z.ZodOptional<z.ZodString>;
1291
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1292
+ }, z.core.$strip>>;
1293
+ resolved_interventions: z.ZodDefault<z.ZodArray<z.ZodObject<{
1294
+ name: z.ZodString;
1295
+ intervention_type: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1296
+ chembl_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1297
+ therapeutic_program_id: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1298
+ target_uniprots: z.ZodDefault<z.ZodArray<z.ZodString>>;
1299
+ resolver_source: z.ZodString;
1300
+ }, z.core.$strip>>>;
1301
+ exclusion_reason: z.ZodOptional<z.ZodString>;
1302
+ }, z.core.$strip>;
1303
+ eligible_for_toxicology_aggregation: z.ZodBoolean;
1304
+ }, z.core.$strip>>>;
822
1305
  }, z.core.$strip>;
1306
+ dropped_count: z.ZodOptional<z.ZodNumber>;
823
1307
  inference_path: z.ZodOptional<z.ZodString>;
824
1308
  truncated: z.ZodOptional<z.ZodBoolean>;
825
1309
  }, z.core.$strip>, z.ZodObject<{
@@ -829,53 +1313,25 @@ export declare const Phase4OutputSchema: z.ZodObject<{
829
1313
  source: z.ZodOptional<z.ZodString>;
830
1314
  }, z.core.$strip>>;
831
1315
  inference_path: z.ZodOptional<z.ZodString>;
1316
+ }, z.core.$strip>, z.ZodObject<{
1317
+ coverage: z.ZodLiteral<"filtered">;
1318
+ filter: z.ZodString;
1319
+ dropped_count: z.ZodNumber;
1320
+ inference_path: z.ZodOptional<z.ZodString>;
832
1321
  }, z.core.$strip>, z.ZodObject<{
833
1322
  coverage: z.ZodLiteral<"not_loaded">;
834
1323
  reason: z.ZodOptional<z.ZodString>;
835
1324
  }, z.core.$strip>], "coverage">;
836
- benchmarks: z.ZodObject<{
837
- therapeutic_area: z.ZodNullable<z.ZodString>;
838
- fallback_to_all_areas: z.ZodBoolean;
839
- phase_transitions: z.ZodRecord<z.ZodString, z.ZodNumber>;
840
- likelihood_of_approval: z.ZodNullable<z.ZodNumber>;
841
- source_attribution: z.ZodString;
842
- }, z.core.$strip>;
843
- }, z.core.$strip>;
844
- safety_profile: z.ZodObject<{
845
- organ_rollup: z.ZodDiscriminatedUnion<[z.ZodObject<{
1325
+ class_precedent: z.ZodDiscriminatedUnion<[z.ZodObject<{
846
1326
  coverage: z.ZodLiteral<"available">;
847
1327
  data: z.ZodObject<{
848
- rows: z.ZodArray<z.ZodObject<{
849
- risk_level: z.ZodEnum<{
850
- high: "high";
851
- medium: "medium";
852
- low: "low";
853
- }>;
854
- signal_type_count: z.ZodNumber;
855
- signals: z.ZodObject<{
856
- chembl_polypharm_count: z.ZodNumber;
857
- faers_count: z.ZodNumber;
858
- trial_ae_count: z.ZodNumber;
859
- class_liability_present: z.ZodBoolean;
860
- }, z.core.$strip>;
861
- evidence: z.ZodArray<z.ZodObject<{
862
- pmid: z.ZodOptional<z.ZodString>;
863
- doi: z.ZodOptional<z.ZodString>;
864
- source: z.ZodString;
865
- predicate: z.ZodOptional<z.ZodString>;
866
- score: z.ZodOptional<z.ZodNumber>;
867
- strength: z.ZodOptional<z.ZodString>;
868
- is_human: z.ZodOptional<z.ZodBoolean>;
869
- is_clinical: z.ZodOptional<z.ZodBoolean>;
870
- excerpt: z.ZodOptional<z.ZodString>;
871
- metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
872
- regulatory_reference: z.ZodOptional<z.ZodObject<{
873
- document: z.ZodString;
874
- section: z.ZodOptional<z.ZodString>;
875
- doc_id: z.ZodOptional<z.ZodString>;
876
- doc_url: z.ZodOptional<z.ZodString>;
877
- }, z.core.$strip>>;
878
- }, z.core.$strip>>;
1328
+ drugs_in_class: z.ZodArray<z.ZodObject<{
1329
+ drug_id: z.ZodNullable<z.ZodString>;
1330
+ drug_name: z.ZodString;
1331
+ max_phase: z.ZodNumber;
1332
+ mechanism: z.ZodOptional<z.ZodString>;
1333
+ }, z.core.$strip>>;
1334
+ per_organ: z.ZodArray<z.ZodObject<{
879
1335
  organ: z.ZodEnum<{
880
1336
  hematologic: "hematologic";
881
1337
  metabolic: "metabolic";
@@ -887,14 +1343,27 @@ export declare const Phase4OutputSchema: z.ZodObject<{
887
1343
  reproductive: "reproductive";
888
1344
  respiratory: "respiratory";
889
1345
  cardiac: "cardiac";
1346
+ vascular: "vascular";
1347
+ pns: "pns";
890
1348
  gi: "gi";
891
1349
  pancreas: "pancreas";
892
1350
  endocrine_thyroid: "endocrine_thyroid";
893
1351
  dermatologic: "dermatologic";
1352
+ ocular: "ocular";
894
1353
  oncology: "oncology";
895
1354
  }>;
1355
+ drug_count_in_class: z.ZodNumber;
1356
+ drugs_with_signal: z.ZodNumber;
1357
+ signal_fraction: z.ZodNumber;
1358
+ is_class_liability: z.ZodBoolean;
1359
+ suppressed_reason: z.ZodNullable<z.ZodString>;
1360
+ top_aes: z.ZodArray<z.ZodObject<{
1361
+ term: z.ZodString;
1362
+ report_count: z.ZodNumber;
1363
+ }, z.core.$strip>>;
896
1364
  }, z.core.$strip>>;
897
1365
  }, z.core.$strip>;
1366
+ dropped_count: z.ZodOptional<z.ZodNumber>;
898
1367
  inference_path: z.ZodOptional<z.ZodString>;
899
1368
  truncated: z.ZodOptional<z.ZodBoolean>;
900
1369
  }, z.core.$strip>, z.ZodObject<{
@@ -904,47 +1373,74 @@ export declare const Phase4OutputSchema: z.ZodObject<{
904
1373
  source: z.ZodOptional<z.ZodString>;
905
1374
  }, z.core.$strip>>;
906
1375
  inference_path: z.ZodOptional<z.ZodString>;
1376
+ }, z.core.$strip>, z.ZodObject<{
1377
+ coverage: z.ZodLiteral<"filtered">;
1378
+ filter: z.ZodString;
1379
+ dropped_count: z.ZodNumber;
1380
+ inference_path: z.ZodOptional<z.ZodString>;
907
1381
  }, z.core.$strip>, z.ZodObject<{
908
1382
  coverage: z.ZodLiteral<"not_loaded">;
909
1383
  reason: z.ZodOptional<z.ZodString>;
910
1384
  }, z.core.$strip>], "coverage">;
911
- faers: z.ZodDiscriminatedUnion<[z.ZodObject<{
1385
+ target_organ_liabilities: z.ZodDiscriminatedUnion<[z.ZodObject<{
912
1386
  coverage: z.ZodLiteral<"available">;
913
1387
  data: z.ZodObject<{
914
- total_reports: z.ZodNumber;
915
- seriousness: z.ZodDiscriminatedUnion<[z.ZodObject<{
916
- coverage: z.ZodLiteral<"available">;
917
- total_reports: z.ZodNumber;
918
- by_seriousness: z.ZodObject<{
919
- death: z.ZodNumber;
920
- life_threatening: z.ZodNumber;
921
- hospitalization: z.ZodNumber;
922
- disabling: z.ZodNumber;
923
- other_serious: z.ZodNumber;
924
- congenital_anomaly: z.ZodNumber;
925
- }, z.core.$strip>;
926
- fatal_report_count: z.ZodNumber;
927
- }, z.core.$strip>, z.ZodObject<{
928
- coverage: z.ZodLiteral<"queried_no_data">;
929
- total_reports: z.ZodNumber;
930
- }, z.core.$strip>], "coverage">;
931
- top_signals: z.ZodArray<z.ZodObject<{
932
- meddra_term: z.ZodString;
933
- organ: z.ZodOptional<z.ZodString>;
934
- report_count: z.ZodNumber;
935
- proportional_reporting_ratio: z.ZodOptional<z.ZodNumber>;
936
- }, z.core.$strip>>;
937
- per_modulator: z.ZodArray<z.ZodObject<{
938
- modulator: z.ZodString;
939
- modulator_id: z.ZodNullable<z.ZodString>;
940
- report_count: z.ZodNumber;
941
- coverage: z.ZodEnum<{
942
- available: "available";
943
- queried_no_data: "queried_no_data";
944
- not_loaded: "not_loaded";
1388
+ rows: z.ZodArray<z.ZodObject<{
1389
+ organ: z.ZodEnum<{
1390
+ hematologic: "hematologic";
1391
+ metabolic: "metabolic";
1392
+ immune: "immune";
1393
+ hepatic: "hepatic";
1394
+ musculoskeletal: "musculoskeletal";
1395
+ cns: "cns";
1396
+ renal: "renal";
1397
+ reproductive: "reproductive";
1398
+ respiratory: "respiratory";
1399
+ cardiac: "cardiac";
1400
+ vascular: "vascular";
1401
+ pns: "pns";
1402
+ gi: "gi";
1403
+ pancreas: "pancreas";
1404
+ endocrine_thyroid: "endocrine_thyroid";
1405
+ dermatologic: "dermatologic";
1406
+ ocular: "ocular";
1407
+ oncology: "oncology";
945
1408
  }>;
1409
+ trail: z.ZodString;
1410
+ mechanism_hypothesis: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1411
+ severity: z.ZodEnum<{
1412
+ high: "high";
1413
+ medium: "medium";
1414
+ low: "low";
1415
+ }>;
1416
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1417
+ state: z.ZodLiteral<"scored">;
1418
+ evidence: z.ZodArray<z.ZodObject<{
1419
+ pmid: z.ZodOptional<z.ZodString>;
1420
+ doi: z.ZodOptional<z.ZodString>;
1421
+ accession: z.ZodOptional<z.ZodString>;
1422
+ source: z.ZodString;
1423
+ predicate: z.ZodOptional<z.ZodString>;
1424
+ score: z.ZodOptional<z.ZodNumber>;
1425
+ strength: z.ZodOptional<z.ZodString>;
1426
+ is_human: z.ZodOptional<z.ZodBoolean>;
1427
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1428
+ excerpt: z.ZodOptional<z.ZodString>;
1429
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1430
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1431
+ document: z.ZodString;
1432
+ section: z.ZodOptional<z.ZodString>;
1433
+ doc_id: z.ZodOptional<z.ZodString>;
1434
+ doc_url: z.ZodOptional<z.ZodString>;
1435
+ }, z.core.$strip>>;
1436
+ }, z.core.$strip>>;
1437
+ }, z.core.$strip>, z.ZodObject<{
1438
+ state: z.ZodLiteral<"unknown">;
1439
+ reason: z.ZodString;
1440
+ }, z.core.$strip>], "state">;
946
1441
  }, z.core.$strip>>;
947
1442
  }, z.core.$strip>;
1443
+ dropped_count: z.ZodOptional<z.ZodNumber>;
948
1444
  inference_path: z.ZodOptional<z.ZodString>;
949
1445
  truncated: z.ZodOptional<z.ZodBoolean>;
950
1446
  }, z.core.$strip>, z.ZodObject<{
@@ -954,34 +1450,75 @@ export declare const Phase4OutputSchema: z.ZodObject<{
954
1450
  source: z.ZodOptional<z.ZodString>;
955
1451
  }, z.core.$strip>>;
956
1452
  inference_path: z.ZodOptional<z.ZodString>;
1453
+ }, z.core.$strip>, z.ZodObject<{
1454
+ coverage: z.ZodLiteral<"filtered">;
1455
+ filter: z.ZodString;
1456
+ dropped_count: z.ZodNumber;
1457
+ inference_path: z.ZodOptional<z.ZodString>;
957
1458
  }, z.core.$strip>, z.ZodObject<{
958
1459
  coverage: z.ZodLiteral<"not_loaded">;
959
1460
  reason: z.ZodOptional<z.ZodString>;
960
1461
  }, z.core.$strip>], "coverage">;
961
- trial_aes: z.ZodDiscriminatedUnion<[z.ZodObject<{
1462
+ regulatory_actions: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
962
1463
  coverage: z.ZodLiteral<"available">;
963
1464
  data: z.ZodObject<{
964
- serious: z.ZodArray<z.ZodObject<{
965
- term: z.ZodString;
966
- incidence_pct: z.ZodNumber;
967
- organ: z.ZodOptional<z.ZodString>;
968
- nct_ids: z.ZodArray<z.ZodString>;
969
- }, z.core.$strip>>;
970
- non_serious: z.ZodArray<z.ZodObject<{
971
- term: z.ZodString;
972
- incidence_pct: z.ZodNumber;
973
- organ: z.ZodOptional<z.ZodString>;
974
- nct_ids: z.ZodArray<z.ZodString>;
975
- }, z.core.$strip>>;
976
- non_serious_floor_pct: z.ZodDefault<z.ZodNumber>;
977
- dropped_uninformative_count: z.ZodOptional<z.ZodNumber>;
978
- coverage_qualifier: z.ZodOptional<z.ZodObject<{
979
- trials_queried: z.ZodNumber;
980
- trials_with_ae_data: z.ZodNumber;
981
- serious_floor_applied: z.ZodOptional<z.ZodNumber>;
982
- non_serious_floor_pct_applied: z.ZodOptional<z.ZodNumber>;
1465
+ rows: z.ZodArray<z.ZodObject<{
1466
+ drug_chembl_id: z.ZodString;
1467
+ drug_name: z.ZodString;
1468
+ agency: z.ZodEnum<{
1469
+ FDA: "FDA";
1470
+ EMA: "EMA";
1471
+ MHRA: "MHRA";
1472
+ PMDA: "PMDA";
1473
+ "Health Canada": "Health Canada";
1474
+ TGA: "TGA";
1475
+ }>;
1476
+ action_kind: z.ZodEnum<{
1477
+ referral: "referral";
1478
+ withdrawal: "withdrawal";
1479
+ indication_restriction: "indication_restriction";
1480
+ REMS: "REMS";
1481
+ black_box: "black_box";
1482
+ DHCP: "DHCP";
1483
+ safety_communication: "safety_communication";
1484
+ label_warning: "label_warning";
1485
+ }>;
1486
+ action_date: z.ZodString;
1487
+ finding: z.ZodString;
1488
+ source_url: z.ZodOptional<z.ZodString>;
1489
+ source_kind: z.ZodEnum<{
1490
+ boxed_warning: "boxed_warning";
1491
+ rems: "rems";
1492
+ referral: "referral";
1493
+ withdrawal: "withdrawal";
1494
+ safety_communication: "safety_communication";
1495
+ label_warning: "label_warning";
1496
+ }>;
1497
+ application_number: z.ZodOptional<z.ZodString>;
1498
+ label_section: z.ZodOptional<z.ZodString>;
1499
+ source_date: z.ZodOptional<z.ZodString>;
1500
+ evidence: z.ZodArray<z.ZodObject<{
1501
+ pmid: z.ZodOptional<z.ZodString>;
1502
+ doi: z.ZodOptional<z.ZodString>;
1503
+ accession: z.ZodOptional<z.ZodString>;
1504
+ source: z.ZodString;
1505
+ predicate: z.ZodOptional<z.ZodString>;
1506
+ score: z.ZodOptional<z.ZodNumber>;
1507
+ strength: z.ZodOptional<z.ZodString>;
1508
+ is_human: z.ZodOptional<z.ZodBoolean>;
1509
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1510
+ excerpt: z.ZodOptional<z.ZodString>;
1511
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1512
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1513
+ document: z.ZodString;
1514
+ section: z.ZodOptional<z.ZodString>;
1515
+ doc_id: z.ZodOptional<z.ZodString>;
1516
+ doc_url: z.ZodOptional<z.ZodString>;
1517
+ }, z.core.$strip>>;
1518
+ }, z.core.$strip>>;
983
1519
  }, z.core.$strip>>;
984
1520
  }, z.core.$strip>;
1521
+ dropped_count: z.ZodOptional<z.ZodNumber>;
985
1522
  inference_path: z.ZodOptional<z.ZodString>;
986
1523
  truncated: z.ZodOptional<z.ZodBoolean>;
987
1524
  }, z.core.$strip>, z.ZodObject<{
@@ -991,39 +1528,122 @@ export declare const Phase4OutputSchema: z.ZodObject<{
991
1528
  source: z.ZodOptional<z.ZodString>;
992
1529
  }, z.core.$strip>>;
993
1530
  inference_path: z.ZodOptional<z.ZodString>;
1531
+ }, z.core.$strip>, z.ZodObject<{
1532
+ coverage: z.ZodLiteral<"filtered">;
1533
+ filter: z.ZodString;
1534
+ dropped_count: z.ZodNumber;
1535
+ inference_path: z.ZodOptional<z.ZodString>;
994
1536
  }, z.core.$strip>, z.ZodObject<{
995
1537
  coverage: z.ZodLiteral<"not_loaded">;
996
1538
  reason: z.ZodOptional<z.ZodString>;
997
- }, z.core.$strip>], "coverage">;
998
- off_target_panel: z.ZodDiscriminatedUnion<[z.ZodObject<{
1539
+ }, z.core.$strip>], "coverage">>;
1540
+ regulatory_organ_signals: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
999
1541
  coverage: z.ZodLiteral<"available">;
1000
1542
  data: z.ZodObject<{
1001
1543
  rows: z.ZodArray<z.ZodObject<{
1002
- off_target_id: z.ZodNullable<z.ZodString>;
1003
- off_target_name: z.ZodString;
1004
- target_class: z.ZodOptional<z.ZodString>;
1005
- pchembl: z.ZodNumber;
1006
- is_safety_panel_target: z.ZodBoolean;
1007
- organ_system: z.ZodNullable<z.ZodString>;
1008
- clinical_consequence: z.ZodNullable<z.ZodString>;
1009
- selectivity: z.ZodUnion<readonly [z.ZodObject<{
1010
- vs_primary_potency: z.ZodObject<{
1011
- primary_pchembl_used: z.ZodNumber;
1012
- primary_source: z.ZodEnum<{
1013
- chembl_target_drug_indication: "chembl_target_drug_indication";
1014
- literature_curated: "literature_curated";
1015
- }>;
1016
- fold: z.ZodNumber;
1017
- log_units: z.ZodNumber;
1018
- }, z.core.$strip>;
1544
+ organ: z.ZodEnum<{
1545
+ hematologic: "hematologic";
1546
+ metabolic: "metabolic";
1547
+ immune: "immune";
1548
+ hepatic: "hepatic";
1549
+ musculoskeletal: "musculoskeletal";
1550
+ cns: "cns";
1551
+ renal: "renal";
1552
+ reproductive: "reproductive";
1553
+ respiratory: "respiratory";
1554
+ cardiac: "cardiac";
1555
+ vascular: "vascular";
1556
+ pns: "pns";
1557
+ gi: "gi";
1558
+ pancreas: "pancreas";
1559
+ endocrine_thyroid: "endocrine_thyroid";
1560
+ dermatologic: "dermatologic";
1561
+ ocular: "ocular";
1562
+ oncology: "oncology";
1563
+ }>;
1564
+ drug_name: z.ZodString;
1565
+ agency: z.ZodLiteral<"FDA">;
1566
+ application_number: z.ZodString;
1567
+ label_section: z.ZodString;
1568
+ excerpt: z.ZodString;
1569
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1570
+ state: z.ZodLiteral<"scored">;
1571
+ evidence: z.ZodArray<z.ZodObject<{
1572
+ pmid: z.ZodOptional<z.ZodString>;
1573
+ doi: z.ZodOptional<z.ZodString>;
1574
+ accession: z.ZodOptional<z.ZodString>;
1575
+ source: z.ZodString;
1576
+ predicate: z.ZodOptional<z.ZodString>;
1577
+ score: z.ZodOptional<z.ZodNumber>;
1578
+ strength: z.ZodOptional<z.ZodString>;
1579
+ is_human: z.ZodOptional<z.ZodBoolean>;
1580
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1581
+ excerpt: z.ZodOptional<z.ZodString>;
1582
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1583
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1584
+ document: z.ZodString;
1585
+ section: z.ZodOptional<z.ZodString>;
1586
+ doc_id: z.ZodOptional<z.ZodString>;
1587
+ doc_url: z.ZodOptional<z.ZodString>;
1588
+ }, z.core.$strip>>;
1589
+ }, z.core.$strip>>;
1019
1590
  }, z.core.$strip>, z.ZodObject<{
1020
- selectivity_unknown: z.ZodLiteral<true>;
1591
+ state: z.ZodLiteral<"unknown">;
1021
1592
  reason: z.ZodString;
1022
- }, z.core.$strip>]>;
1023
- selectivity_window_below_threshold: z.ZodBoolean;
1024
- evidence: z.ZodArray<z.ZodObject<{
1593
+ }, z.core.$strip>], "state">;
1594
+ }, z.core.$strip>>;
1595
+ }, z.core.$strip>;
1596
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1597
+ inference_path: z.ZodOptional<z.ZodString>;
1598
+ truncated: z.ZodOptional<z.ZodBoolean>;
1599
+ }, z.core.$strip>, z.ZodObject<{
1600
+ coverage: z.ZodLiteral<"queried_no_data">;
1601
+ error: z.ZodOptional<z.ZodObject<{
1602
+ message: z.ZodString;
1603
+ source: z.ZodOptional<z.ZodString>;
1604
+ }, z.core.$strip>>;
1605
+ inference_path: z.ZodOptional<z.ZodString>;
1606
+ }, z.core.$strip>, z.ZodObject<{
1607
+ coverage: z.ZodLiteral<"filtered">;
1608
+ filter: z.ZodString;
1609
+ dropped_count: z.ZodNumber;
1610
+ inference_path: z.ZodOptional<z.ZodString>;
1611
+ }, z.core.$strip>, z.ZodObject<{
1612
+ coverage: z.ZodLiteral<"not_loaded">;
1613
+ reason: z.ZodOptional<z.ZodString>;
1614
+ }, z.core.$strip>], "coverage">>;
1615
+ }, z.core.$strip>;
1616
+ safety_corroboration: z.ZodDiscriminatedUnion<[z.ZodObject<{
1617
+ coverage: z.ZodLiteral<"available">;
1618
+ data: z.ZodObject<{
1619
+ rows: z.ZodArray<z.ZodObject<{
1620
+ organ: z.ZodEnum<{
1621
+ hematologic: "hematologic";
1622
+ metabolic: "metabolic";
1623
+ immune: "immune";
1624
+ hepatic: "hepatic";
1625
+ musculoskeletal: "musculoskeletal";
1626
+ cns: "cns";
1627
+ renal: "renal";
1628
+ reproductive: "reproductive";
1629
+ respiratory: "respiratory";
1630
+ cardiac: "cardiac";
1631
+ vascular: "vascular";
1632
+ pns: "pns";
1633
+ gi: "gi";
1634
+ pancreas: "pancreas";
1635
+ endocrine_thyroid: "endocrine_thyroid";
1636
+ dermatologic: "dermatologic";
1637
+ ocular: "ocular";
1638
+ oncology: "oncology";
1639
+ }>;
1640
+ contributions: z.ZodArray<z.ZodObject<{
1641
+ source: z.ZodString;
1642
+ signal: z.ZodString;
1643
+ evidence: z.ZodObject<{
1025
1644
  pmid: z.ZodOptional<z.ZodString>;
1026
1645
  doi: z.ZodOptional<z.ZodString>;
1646
+ accession: z.ZodOptional<z.ZodString>;
1027
1647
  source: z.ZodString;
1028
1648
  predicate: z.ZodOptional<z.ZodString>;
1029
1649
  score: z.ZodOptional<z.ZodNumber>;
@@ -1038,38 +1658,16 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1038
1658
  doc_id: z.ZodOptional<z.ZodString>;
1039
1659
  doc_url: z.ZodOptional<z.ZodString>;
1040
1660
  }, z.core.$strip>>;
1041
- }, z.core.$strip>>;
1042
- metadata: z.ZodOptional<z.ZodObject<{
1043
- merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
1044
- }, z.core.$strip>>;
1045
- relationship: z.ZodLiteral<"off_target">;
1661
+ }, z.core.$strip>;
1046
1662
  }, z.core.$strip>>;
1047
- excluded_rows: z.ZodArray<z.ZodObject<{
1048
- off_target_id: z.ZodNullable<z.ZodString>;
1049
- off_target_name: z.ZodString;
1050
- target_class: z.ZodOptional<z.ZodString>;
1051
- pchembl: z.ZodNumber;
1052
- is_safety_panel_target: z.ZodBoolean;
1053
- organ_system: z.ZodNullable<z.ZodString>;
1054
- clinical_consequence: z.ZodNullable<z.ZodString>;
1055
- selectivity: z.ZodUnion<readonly [z.ZodObject<{
1056
- vs_primary_potency: z.ZodObject<{
1057
- primary_pchembl_used: z.ZodNumber;
1058
- primary_source: z.ZodEnum<{
1059
- chembl_target_drug_indication: "chembl_target_drug_indication";
1060
- literature_curated: "literature_curated";
1061
- }>;
1062
- fold: z.ZodNumber;
1063
- log_units: z.ZodNumber;
1064
- }, z.core.$strip>;
1065
- }, z.core.$strip>, z.ZodObject<{
1066
- selectivity_unknown: z.ZodLiteral<true>;
1067
- reason: z.ZodString;
1068
- }, z.core.$strip>]>;
1069
- selectivity_window_below_threshold: z.ZodBoolean;
1663
+ corroborating_sources: z.ZodArray<z.ZodString>;
1664
+ independent_source_count: z.ZodNumber;
1665
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1666
+ state: z.ZodLiteral<"scored">;
1070
1667
  evidence: z.ZodArray<z.ZodObject<{
1071
1668
  pmid: z.ZodOptional<z.ZodString>;
1072
1669
  doi: z.ZodOptional<z.ZodString>;
1670
+ accession: z.ZodOptional<z.ZodString>;
1073
1671
  source: z.ZodString;
1074
1672
  predicate: z.ZodOptional<z.ZodString>;
1075
1673
  score: z.ZodOptional<z.ZodNumber>;
@@ -1085,150 +1683,131 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1085
1683
  doc_url: z.ZodOptional<z.ZodString>;
1086
1684
  }, z.core.$strip>>;
1087
1685
  }, z.core.$strip>>;
1088
- metadata: z.ZodOptional<z.ZodObject<{
1089
- merged_chembl_ids: z.ZodOptional<z.ZodArray<z.ZodString>>;
1090
- }, z.core.$strip>>;
1091
- relationship: z.ZodEnum<{
1092
- intended_co_target: "intended_co_target";
1093
- on_target_self_hit: "on_target_self_hit";
1094
- obligate_cofactor: "obligate_cofactor";
1095
- }>;
1686
+ }, z.core.$strip>, z.ZodObject<{
1687
+ state: z.ZodLiteral<"unknown">;
1096
1688
  reason: z.ZodString;
1097
- }, z.core.$strip>>;
1098
- }, z.core.$strip>;
1099
- inference_path: z.ZodOptional<z.ZodString>;
1100
- truncated: z.ZodOptional<z.ZodBoolean>;
1101
- }, z.core.$strip>, z.ZodObject<{
1102
- coverage: z.ZodLiteral<"queried_no_data">;
1103
- error: z.ZodOptional<z.ZodObject<{
1104
- message: z.ZodString;
1105
- source: z.ZodOptional<z.ZodString>;
1689
+ }, z.core.$strip>], "state">;
1106
1690
  }, z.core.$strip>>;
1107
- inference_path: z.ZodOptional<z.ZodString>;
1108
- }, z.core.$strip>, z.ZodObject<{
1109
- coverage: z.ZodLiteral<"not_loaded">;
1110
- reason: z.ZodOptional<z.ZodString>;
1111
- }, z.core.$strip>], "coverage">;
1112
- failed_trials_safety_lens: z.ZodDiscriminatedUnion<[z.ZodObject<{
1113
- coverage: z.ZodLiteral<"available">;
1114
- data: z.ZodObject<{
1115
- rows: z.ZodArray<z.ZodObject<{
1116
- nct_id: z.ZodString;
1117
- title: z.ZodString;
1118
- why_stopped: z.ZodString;
1119
- classifier: z.ZodEnum<{
1120
- rules: "rules";
1121
- llm: "llm";
1122
- }>;
1123
- failure_category: z.ZodDiscriminatedUnion<[z.ZodObject<{
1124
- category: z.ZodLiteral<"safety">;
1125
- safety_evidence_excerpt: z.ZodString;
1126
- }, z.core.$strip>, z.ZodObject<{
1127
- category: z.ZodLiteral<"strategic">;
1128
- category_evidence_excerpt: z.ZodString;
1129
- }, z.core.$strip>, z.ZodObject<{
1130
- category: z.ZodLiteral<"operational">;
1131
- category_evidence_excerpt: z.ZodString;
1691
+ sources_considered: z.ZodArray<z.ZodString>;
1692
+ min_independent_sources: z.ZodNumber;
1693
+ }, z.core.$strip>;
1694
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1695
+ inference_path: z.ZodOptional<z.ZodString>;
1696
+ truncated: z.ZodOptional<z.ZodBoolean>;
1697
+ }, z.core.$strip>, z.ZodObject<{
1698
+ coverage: z.ZodLiteral<"queried_no_data">;
1699
+ error: z.ZodOptional<z.ZodObject<{
1700
+ message: z.ZodString;
1701
+ source: z.ZodOptional<z.ZodString>;
1702
+ }, z.core.$strip>>;
1703
+ inference_path: z.ZodOptional<z.ZodString>;
1704
+ }, z.core.$strip>, z.ZodObject<{
1705
+ coverage: z.ZodLiteral<"filtered">;
1706
+ filter: z.ZodString;
1707
+ dropped_count: z.ZodNumber;
1708
+ inference_path: z.ZodOptional<z.ZodString>;
1709
+ }, z.core.$strip>, z.ZodObject<{
1710
+ coverage: z.ZodLiteral<"not_loaded">;
1711
+ reason: z.ZodOptional<z.ZodString>;
1712
+ }, z.core.$strip>], "coverage">;
1713
+ claim_investigation: z.ZodDiscriminatedUnion<[z.ZodObject<{
1714
+ coverage: z.ZodLiteral<"available">;
1715
+ data: z.ZodObject<{
1716
+ rows: z.ZodArray<z.ZodObject<{
1717
+ organ: z.ZodEnum<{
1718
+ hematologic: "hematologic";
1719
+ metabolic: "metabolic";
1720
+ immune: "immune";
1721
+ hepatic: "hepatic";
1722
+ musculoskeletal: "musculoskeletal";
1723
+ cns: "cns";
1724
+ renal: "renal";
1725
+ reproductive: "reproductive";
1726
+ respiratory: "respiratory";
1727
+ cardiac: "cardiac";
1728
+ vascular: "vascular";
1729
+ pns: "pns";
1730
+ gi: "gi";
1731
+ pancreas: "pancreas";
1732
+ endocrine_thyroid: "endocrine_thyroid";
1733
+ dermatologic: "dermatologic";
1734
+ ocular: "ocular";
1735
+ oncology: "oncology";
1736
+ }>;
1737
+ mechanism: z.ZodNullable<z.ZodObject<{
1738
+ statement: z.ZodString;
1739
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1740
+ state: z.ZodLiteral<"scored">;
1741
+ evidence: z.ZodArray<z.ZodObject<{
1742
+ pmid: z.ZodOptional<z.ZodString>;
1743
+ doi: z.ZodOptional<z.ZodString>;
1744
+ accession: z.ZodOptional<z.ZodString>;
1745
+ source: z.ZodString;
1746
+ predicate: z.ZodOptional<z.ZodString>;
1747
+ score: z.ZodOptional<z.ZodNumber>;
1748
+ strength: z.ZodOptional<z.ZodString>;
1749
+ is_human: z.ZodOptional<z.ZodBoolean>;
1750
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1751
+ excerpt: z.ZodOptional<z.ZodString>;
1752
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1753
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1754
+ document: z.ZodString;
1755
+ section: z.ZodOptional<z.ZodString>;
1756
+ doc_id: z.ZodOptional<z.ZodString>;
1757
+ doc_url: z.ZodOptional<z.ZodString>;
1758
+ }, z.core.$strip>>;
1759
+ }, z.core.$strip>>;
1132
1760
  }, z.core.$strip>, z.ZodObject<{
1133
- category: z.ZodLiteral<"efficacy">;
1134
- category_evidence_excerpt: z.ZodString;
1135
- }, z.core.$strip>], "category">;
1136
- }, z.core.$strip>>;
1137
- }, z.core.$strip>;
1138
- inference_path: z.ZodOptional<z.ZodString>;
1139
- truncated: z.ZodOptional<z.ZodBoolean>;
1140
- }, z.core.$strip>, z.ZodObject<{
1141
- coverage: z.ZodLiteral<"queried_no_data">;
1142
- error: z.ZodOptional<z.ZodObject<{
1143
- message: z.ZodString;
1144
- source: z.ZodOptional<z.ZodString>;
1145
- }, z.core.$strip>>;
1146
- inference_path: z.ZodOptional<z.ZodString>;
1147
- }, z.core.$strip>, z.ZodObject<{
1148
- coverage: z.ZodLiteral<"not_loaded">;
1149
- reason: z.ZodOptional<z.ZodString>;
1150
- }, z.core.$strip>], "coverage">;
1151
- class_precedent: z.ZodDiscriminatedUnion<[z.ZodObject<{
1152
- coverage: z.ZodLiteral<"available">;
1153
- data: z.ZodObject<{
1154
- drugs_in_class: z.ZodArray<z.ZodObject<{
1155
- drug_id: z.ZodNullable<z.ZodString>;
1156
- drug_name: z.ZodString;
1157
- max_phase: z.ZodNumber;
1158
- mechanism: z.ZodOptional<z.ZodString>;
1761
+ state: z.ZodLiteral<"unknown">;
1762
+ reason: z.ZodString;
1763
+ }, z.core.$strip>], "state">;
1159
1764
  }, z.core.$strip>>;
1160
- per_organ: z.ZodArray<z.ZodObject<{
1161
- organ: z.ZodString;
1162
- drug_count_in_class: z.ZodNumber;
1163
- drugs_with_signal: z.ZodNumber;
1164
- signal_fraction: z.ZodNumber;
1165
- is_class_liability: z.ZodBoolean;
1166
- suppressed_reason: z.ZodNullable<z.ZodString>;
1167
- top_aes: z.ZodArray<z.ZodObject<{
1168
- term: z.ZodString;
1169
- report_count: z.ZodNumber;
1170
- }, z.core.$strip>>;
1765
+ critique: z.ZodNullable<z.ZodObject<{
1766
+ objection: z.ZodString;
1767
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1768
+ state: z.ZodLiteral<"scored">;
1769
+ evidence: z.ZodArray<z.ZodObject<{
1770
+ pmid: z.ZodOptional<z.ZodString>;
1771
+ doi: z.ZodOptional<z.ZodString>;
1772
+ accession: z.ZodOptional<z.ZodString>;
1773
+ source: z.ZodString;
1774
+ predicate: z.ZodOptional<z.ZodString>;
1775
+ score: z.ZodOptional<z.ZodNumber>;
1776
+ strength: z.ZodOptional<z.ZodString>;
1777
+ is_human: z.ZodOptional<z.ZodBoolean>;
1778
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1779
+ excerpt: z.ZodOptional<z.ZodString>;
1780
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1781
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1782
+ document: z.ZodString;
1783
+ section: z.ZodOptional<z.ZodString>;
1784
+ doc_id: z.ZodOptional<z.ZodString>;
1785
+ doc_url: z.ZodOptional<z.ZodString>;
1786
+ }, z.core.$strip>>;
1787
+ }, z.core.$strip>>;
1788
+ }, z.core.$strip>, z.ZodObject<{
1789
+ state: z.ZodLiteral<"unknown">;
1790
+ reason: z.ZodString;
1791
+ }, z.core.$strip>], "state">;
1171
1792
  }, z.core.$strip>>;
1172
- }, z.core.$strip>;
1173
- inference_path: z.ZodOptional<z.ZodString>;
1174
- truncated: z.ZodOptional<z.ZodBoolean>;
1175
- }, z.core.$strip>, z.ZodObject<{
1176
- coverage: z.ZodLiteral<"queried_no_data">;
1177
- error: z.ZodOptional<z.ZodObject<{
1178
- message: z.ZodString;
1179
- source: z.ZodOptional<z.ZodString>;
1180
- }, z.core.$strip>>;
1181
- inference_path: z.ZodOptional<z.ZodString>;
1182
- }, z.core.$strip>, z.ZodObject<{
1183
- coverage: z.ZodLiteral<"not_loaded">;
1184
- reason: z.ZodOptional<z.ZodString>;
1185
- }, z.core.$strip>], "coverage">;
1186
- target_organ_liabilities: z.ZodArray<z.ZodObject<{
1187
- organ: z.ZodString;
1188
- trail: z.ZodString;
1189
- mechanism_hypothesis: z.ZodOptional<z.ZodNullable<z.ZodString>>;
1190
- }, z.core.$strip>>;
1191
- regulatory_actions: z.ZodOptional<z.ZodDiscriminatedUnion<[z.ZodObject<{
1192
- coverage: z.ZodLiteral<"available">;
1193
- data: z.ZodObject<{
1194
- rows: z.ZodArray<z.ZodObject<{
1195
- drug_chembl_id: z.ZodString;
1196
- drug_name: z.ZodString;
1197
- agency: z.ZodEnum<{
1198
- FDA: "FDA";
1199
- EMA: "EMA";
1200
- MHRA: "MHRA";
1201
- PMDA: "PMDA";
1202
- "Health Canada": "Health Canada";
1203
- TGA: "TGA";
1204
- }>;
1205
- action_kind: z.ZodEnum<{
1206
- referral: "referral";
1207
- withdrawal: "withdrawal";
1208
- indication_restriction: "indication_restriction";
1209
- REMS: "REMS";
1210
- black_box: "black_box";
1211
- DHCP: "DHCP";
1212
- safety_communication: "safety_communication";
1213
- label_warning: "label_warning";
1214
- }>;
1215
- action_date: z.ZodString;
1216
- finding: z.ZodString;
1217
- source_url: z.ZodOptional<z.ZodString>;
1218
- source_kind: z.ZodOptional<z.ZodEnum<{
1219
- boxed_warning: "boxed_warning";
1220
- rems: "rems";
1221
- referral: "referral";
1222
- withdrawal: "withdrawal";
1223
- safety_communication: "safety_communication";
1224
- label_warning: "label_warning";
1225
- }>>;
1226
- application_number: z.ZodOptional<z.ZodString>;
1227
- label_section: z.ZodOptional<z.ZodString>;
1228
- source_date: z.ZodOptional<z.ZodString>;
1793
+ verdict: z.ZodEnum<{
1794
+ undetermined: "undetermined";
1795
+ upheld: "upheld";
1796
+ weakened: "weakened";
1797
+ overturned: "overturned";
1798
+ }>;
1799
+ rounds_run: z.ZodNumber;
1800
+ convergence: z.ZodEnum<{
1801
+ verdict_terminal: "verdict_terminal";
1802
+ verdict_settled: "verdict_settled";
1803
+ round_bound_reached: "round_bound_reached";
1804
+ }>;
1805
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1806
+ state: z.ZodLiteral<"scored">;
1229
1807
  evidence: z.ZodArray<z.ZodObject<{
1230
1808
  pmid: z.ZodOptional<z.ZodString>;
1231
1809
  doi: z.ZodOptional<z.ZodString>;
1810
+ accession: z.ZodOptional<z.ZodString>;
1232
1811
  source: z.ZodString;
1233
1812
  predicate: z.ZodOptional<z.ZodString>;
1234
1813
  score: z.ZodOptional<z.ZodNumber>;
@@ -1244,31 +1823,115 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1244
1823
  doc_url: z.ZodOptional<z.ZodString>;
1245
1824
  }, z.core.$strip>>;
1246
1825
  }, z.core.$strip>>;
1247
- }, z.core.$strip>>;
1248
- }, z.core.$strip>;
1249
- inference_path: z.ZodOptional<z.ZodString>;
1250
- truncated: z.ZodOptional<z.ZodBoolean>;
1251
- }, z.core.$strip>, z.ZodObject<{
1252
- coverage: z.ZodLiteral<"queried_no_data">;
1253
- error: z.ZodOptional<z.ZodObject<{
1254
- message: z.ZodString;
1255
- source: z.ZodOptional<z.ZodString>;
1826
+ }, z.core.$strip>, z.ZodObject<{
1827
+ state: z.ZodLiteral<"unknown">;
1828
+ reason: z.ZodString;
1829
+ }, z.core.$strip>], "state">;
1256
1830
  }, z.core.$strip>>;
1257
- inference_path: z.ZodOptional<z.ZodString>;
1258
- }, z.core.$strip>, z.ZodObject<{
1259
- coverage: z.ZodLiteral<"not_loaded">;
1260
- reason: z.ZodOptional<z.ZodString>;
1261
- }, z.core.$strip>], "coverage">>;
1262
- }, z.core.$strip>;
1831
+ not_investigated: z.ZodArray<z.ZodObject<{
1832
+ organ: z.ZodEnum<{
1833
+ hematologic: "hematologic";
1834
+ metabolic: "metabolic";
1835
+ immune: "immune";
1836
+ hepatic: "hepatic";
1837
+ musculoskeletal: "musculoskeletal";
1838
+ cns: "cns";
1839
+ renal: "renal";
1840
+ reproductive: "reproductive";
1841
+ respiratory: "respiratory";
1842
+ cardiac: "cardiac";
1843
+ vascular: "vascular";
1844
+ pns: "pns";
1845
+ gi: "gi";
1846
+ pancreas: "pancreas";
1847
+ endocrine_thyroid: "endocrine_thyroid";
1848
+ dermatologic: "dermatologic";
1849
+ ocular: "ocular";
1850
+ oncology: "oncology";
1851
+ }>;
1852
+ reason: z.ZodEnum<{
1853
+ not_corroborated: "not_corroborated";
1854
+ exceeded_claim_budget: "exceeded_claim_budget";
1855
+ investigation_unavailable: "investigation_unavailable";
1856
+ }>;
1857
+ detail: z.ZodString;
1858
+ }, z.core.$strip>>;
1859
+ round_bound: z.ZodNumber;
1860
+ claim_budget: z.ZodNumber;
1861
+ }, z.core.$strip>;
1862
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1863
+ inference_path: z.ZodOptional<z.ZodString>;
1864
+ truncated: z.ZodOptional<z.ZodBoolean>;
1865
+ }, z.core.$strip>, z.ZodObject<{
1866
+ coverage: z.ZodLiteral<"queried_no_data">;
1867
+ error: z.ZodOptional<z.ZodObject<{
1868
+ message: z.ZodString;
1869
+ source: z.ZodOptional<z.ZodString>;
1870
+ }, z.core.$strip>>;
1871
+ inference_path: z.ZodOptional<z.ZodString>;
1872
+ }, z.core.$strip>, z.ZodObject<{
1873
+ coverage: z.ZodLiteral<"filtered">;
1874
+ filter: z.ZodString;
1875
+ dropped_count: z.ZodNumber;
1876
+ inference_path: z.ZodOptional<z.ZodString>;
1877
+ }, z.core.$strip>, z.ZodObject<{
1878
+ coverage: z.ZodLiteral<"not_loaded">;
1879
+ reason: z.ZodOptional<z.ZodString>;
1880
+ }, z.core.$strip>], "coverage">;
1263
1881
  off_tissue_risk: z.ZodDiscriminatedUnion<[z.ZodObject<{
1264
1882
  coverage: z.ZodLiteral<"available">;
1265
1883
  data: z.ZodObject<{
1266
1884
  rows: z.ZodArray<z.ZodObject<{
1267
1885
  tissue: z.ZodString;
1268
- organ: z.ZodString;
1886
+ organ: z.ZodEnum<{
1887
+ hematologic: "hematologic";
1888
+ metabolic: "metabolic";
1889
+ immune: "immune";
1890
+ hepatic: "hepatic";
1891
+ musculoskeletal: "musculoskeletal";
1892
+ cns: "cns";
1893
+ renal: "renal";
1894
+ reproductive: "reproductive";
1895
+ respiratory: "respiratory";
1896
+ cardiac: "cardiac";
1897
+ vascular: "vascular";
1898
+ pns: "pns";
1899
+ gi: "gi";
1900
+ pancreas: "pancreas";
1901
+ endocrine_thyroid: "endocrine_thyroid";
1902
+ dermatologic: "dermatologic";
1903
+ ocular: "ocular";
1904
+ oncology: "oncology";
1905
+ }>;
1269
1906
  tpm: z.ZodNumber;
1907
+ support: z.ZodDiscriminatedUnion<[z.ZodObject<{
1908
+ state: z.ZodLiteral<"scored">;
1909
+ evidence: z.ZodArray<z.ZodObject<{
1910
+ pmid: z.ZodOptional<z.ZodString>;
1911
+ doi: z.ZodOptional<z.ZodString>;
1912
+ accession: z.ZodOptional<z.ZodString>;
1913
+ source: z.ZodString;
1914
+ predicate: z.ZodOptional<z.ZodString>;
1915
+ score: z.ZodOptional<z.ZodNumber>;
1916
+ strength: z.ZodOptional<z.ZodString>;
1917
+ is_human: z.ZodOptional<z.ZodBoolean>;
1918
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
1919
+ excerpt: z.ZodOptional<z.ZodString>;
1920
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1921
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
1922
+ document: z.ZodString;
1923
+ section: z.ZodOptional<z.ZodString>;
1924
+ doc_id: z.ZodOptional<z.ZodString>;
1925
+ doc_url: z.ZodOptional<z.ZodString>;
1926
+ }, z.core.$strip>>;
1927
+ }, z.core.$strip>>;
1928
+ }, z.core.$strip>, z.ZodObject<{
1929
+ state: z.ZodLiteral<"unknown">;
1930
+ reason: z.ZodString;
1931
+ }, z.core.$strip>], "state">;
1270
1932
  }, z.core.$strip>>;
1271
1933
  }, z.core.$strip>;
1934
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1272
1935
  inference_path: z.ZodOptional<z.ZodString>;
1273
1936
  truncated: z.ZodOptional<z.ZodBoolean>;
1274
1937
  }, z.core.$strip>, z.ZodObject<{
@@ -1278,44 +1941,16 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1278
1941
  source: z.ZodOptional<z.ZodString>;
1279
1942
  }, z.core.$strip>>;
1280
1943
  inference_path: z.ZodOptional<z.ZodString>;
1944
+ }, z.core.$strip>, z.ZodObject<{
1945
+ coverage: z.ZodLiteral<"filtered">;
1946
+ filter: z.ZodString;
1947
+ dropped_count: z.ZodNumber;
1948
+ inference_path: z.ZodOptional<z.ZodString>;
1281
1949
  }, z.core.$strip>, z.ZodObject<{
1282
1950
  coverage: z.ZodLiteral<"not_loaded">;
1283
1951
  reason: z.ZodOptional<z.ZodString>;
1284
1952
  }, z.core.$strip>], "coverage">;
1285
1953
  reference_biology: z.ZodObject<{
1286
- normal_tissue_expression: z.ZodDiscriminatedUnion<[z.ZodObject<{
1287
- coverage: z.ZodLiteral<"available">;
1288
- data: z.ZodObject<{
1289
- source: z.ZodEnum<{
1290
- gtex: "gtex";
1291
- hpa_consensus: "hpa_consensus";
1292
- hpa_rna_tissue: "hpa_rna_tissue";
1293
- }>;
1294
- unit: z.ZodEnum<{
1295
- tpm: "tpm";
1296
- ntpm: "ntpm";
1297
- consensus_normalized: "consensus_normalized";
1298
- }>;
1299
- normalization_notes: z.ZodString;
1300
- rows: z.ZodArray<z.ZodObject<{
1301
- tissue: z.ZodString;
1302
- value: z.ZodNumber;
1303
- percentile_rank: z.ZodOptional<z.ZodNumber>;
1304
- }, z.core.$strip>>;
1305
- }, z.core.$strip>;
1306
- inference_path: z.ZodOptional<z.ZodString>;
1307
- truncated: z.ZodOptional<z.ZodBoolean>;
1308
- }, z.core.$strip>, z.ZodObject<{
1309
- coverage: z.ZodLiteral<"queried_no_data">;
1310
- error: z.ZodOptional<z.ZodObject<{
1311
- message: z.ZodString;
1312
- source: z.ZodOptional<z.ZodString>;
1313
- }, z.core.$strip>>;
1314
- inference_path: z.ZodOptional<z.ZodString>;
1315
- }, z.core.$strip>, z.ZodObject<{
1316
- coverage: z.ZodLiteral<"not_loaded">;
1317
- reason: z.ZodOptional<z.ZodString>;
1318
- }, z.core.$strip>], "coverage">;
1319
1954
  therapeutic_area_associations: z.ZodDiscriminatedUnion<[z.ZodObject<{
1320
1955
  coverage: z.ZodLiteral<"available">;
1321
1956
  data: z.ZodObject<{
@@ -1329,6 +1964,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1329
1964
  evidence: z.ZodArray<z.ZodObject<{
1330
1965
  pmid: z.ZodOptional<z.ZodString>;
1331
1966
  doi: z.ZodOptional<z.ZodString>;
1967
+ accession: z.ZodOptional<z.ZodString>;
1332
1968
  source: z.ZodString;
1333
1969
  predicate: z.ZodOptional<z.ZodString>;
1334
1970
  score: z.ZodOptional<z.ZodNumber>;
@@ -1346,6 +1982,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1346
1982
  }, z.core.$strip>>;
1347
1983
  }, z.core.$strip>>;
1348
1984
  }, z.core.$strip>;
1985
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1349
1986
  inference_path: z.ZodOptional<z.ZodString>;
1350
1987
  truncated: z.ZodOptional<z.ZodBoolean>;
1351
1988
  }, z.core.$strip>, z.ZodObject<{
@@ -1355,6 +1992,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1355
1992
  source: z.ZodOptional<z.ZodString>;
1356
1993
  }, z.core.$strip>>;
1357
1994
  inference_path: z.ZodOptional<z.ZodString>;
1995
+ }, z.core.$strip>, z.ZodObject<{
1996
+ coverage: z.ZodLiteral<"filtered">;
1997
+ filter: z.ZodString;
1998
+ dropped_count: z.ZodNumber;
1999
+ inference_path: z.ZodOptional<z.ZodString>;
1358
2000
  }, z.core.$strip>, z.ZodObject<{
1359
2001
  coverage: z.ZodLiteral<"not_loaded">;
1360
2002
  reason: z.ZodOptional<z.ZodString>;
@@ -1372,6 +2014,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1372
2014
  evidence: z.ZodArray<z.ZodObject<{
1373
2015
  pmid: z.ZodOptional<z.ZodString>;
1374
2016
  doi: z.ZodOptional<z.ZodString>;
2017
+ accession: z.ZodOptional<z.ZodString>;
1375
2018
  source: z.ZodString;
1376
2019
  predicate: z.ZodOptional<z.ZodString>;
1377
2020
  score: z.ZodOptional<z.ZodNumber>;
@@ -1389,6 +2032,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1389
2032
  }, z.core.$strip>>;
1390
2033
  }, z.core.$strip>>;
1391
2034
  }, z.core.$strip>;
2035
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1392
2036
  inference_path: z.ZodOptional<z.ZodString>;
1393
2037
  truncated: z.ZodOptional<z.ZodBoolean>;
1394
2038
  }, z.core.$strip>, z.ZodObject<{
@@ -1398,6 +2042,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1398
2042
  source: z.ZodOptional<z.ZodString>;
1399
2043
  }, z.core.$strip>>;
1400
2044
  inference_path: z.ZodOptional<z.ZodString>;
2045
+ }, z.core.$strip>, z.ZodObject<{
2046
+ coverage: z.ZodLiteral<"filtered">;
2047
+ filter: z.ZodString;
2048
+ dropped_count: z.ZodNumber;
2049
+ inference_path: z.ZodOptional<z.ZodString>;
1401
2050
  }, z.core.$strip>, z.ZodObject<{
1402
2051
  coverage: z.ZodLiteral<"not_loaded">;
1403
2052
  reason: z.ZodOptional<z.ZodString>;
@@ -1415,6 +2064,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1415
2064
  evidence: z.ZodArray<z.ZodObject<{
1416
2065
  pmid: z.ZodOptional<z.ZodString>;
1417
2066
  doi: z.ZodOptional<z.ZodString>;
2067
+ accession: z.ZodOptional<z.ZodString>;
1418
2068
  source: z.ZodString;
1419
2069
  predicate: z.ZodOptional<z.ZodString>;
1420
2070
  score: z.ZodOptional<z.ZodNumber>;
@@ -1438,6 +2088,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1438
2088
  }, z.core.$strip>;
1439
2089
  }, z.core.$strip>>;
1440
2090
  }, z.core.$strip>;
2091
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1441
2092
  inference_path: z.ZodOptional<z.ZodString>;
1442
2093
  truncated: z.ZodOptional<z.ZodBoolean>;
1443
2094
  }, z.core.$strip>, z.ZodObject<{
@@ -1447,6 +2098,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1447
2098
  source: z.ZodOptional<z.ZodString>;
1448
2099
  }, z.core.$strip>>;
1449
2100
  inference_path: z.ZodOptional<z.ZodString>;
2101
+ }, z.core.$strip>, z.ZodObject<{
2102
+ coverage: z.ZodLiteral<"filtered">;
2103
+ filter: z.ZodString;
2104
+ dropped_count: z.ZodNumber;
2105
+ inference_path: z.ZodOptional<z.ZodString>;
1450
2106
  }, z.core.$strip>, z.ZodObject<{
1451
2107
  coverage: z.ZodLiteral<"not_loaded">;
1452
2108
  reason: z.ZodOptional<z.ZodString>;
@@ -1464,6 +2120,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1464
2120
  source: z.ZodString;
1465
2121
  }, z.core.$strip>>;
1466
2122
  }, z.core.$strip>;
2123
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1467
2124
  inference_path: z.ZodOptional<z.ZodString>;
1468
2125
  truncated: z.ZodOptional<z.ZodBoolean>;
1469
2126
  }, z.core.$strip>, z.ZodObject<{
@@ -1473,6 +2130,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1473
2130
  source: z.ZodOptional<z.ZodString>;
1474
2131
  }, z.core.$strip>>;
1475
2132
  inference_path: z.ZodOptional<z.ZodString>;
2133
+ }, z.core.$strip>, z.ZodObject<{
2134
+ coverage: z.ZodLiteral<"filtered">;
2135
+ filter: z.ZodString;
2136
+ dropped_count: z.ZodNumber;
2137
+ inference_path: z.ZodOptional<z.ZodString>;
1476
2138
  }, z.core.$strip>, z.ZodObject<{
1477
2139
  coverage: z.ZodLiteral<"not_loaded">;
1478
2140
  reason: z.ZodOptional<z.ZodString>;
@@ -1488,6 +2150,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1488
2150
  review_status: z.ZodString;
1489
2151
  }, z.core.$strip>>;
1490
2152
  }, z.core.$strip>;
2153
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1491
2154
  inference_path: z.ZodOptional<z.ZodString>;
1492
2155
  truncated: z.ZodOptional<z.ZodBoolean>;
1493
2156
  }, z.core.$strip>, z.ZodObject<{
@@ -1497,6 +2160,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1497
2160
  source: z.ZodOptional<z.ZodString>;
1498
2161
  }, z.core.$strip>>;
1499
2162
  inference_path: z.ZodOptional<z.ZodString>;
2163
+ }, z.core.$strip>, z.ZodObject<{
2164
+ coverage: z.ZodLiteral<"filtered">;
2165
+ filter: z.ZodString;
2166
+ dropped_count: z.ZodNumber;
2167
+ inference_path: z.ZodOptional<z.ZodString>;
1500
2168
  }, z.core.$strip>, z.ZodObject<{
1501
2169
  coverage: z.ZodLiteral<"not_loaded">;
1502
2170
  reason: z.ZodOptional<z.ZodString>;
@@ -1515,6 +2183,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1515
2183
  evidence: z.ZodArray<z.ZodObject<{
1516
2184
  pmid: z.ZodOptional<z.ZodString>;
1517
2185
  doi: z.ZodOptional<z.ZodString>;
2186
+ accession: z.ZodOptional<z.ZodString>;
1518
2187
  source: z.ZodString;
1519
2188
  predicate: z.ZodOptional<z.ZodString>;
1520
2189
  score: z.ZodOptional<z.ZodNumber>;
@@ -1532,6 +2201,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1532
2201
  }, z.core.$strip>>;
1533
2202
  }, z.core.$strip>>;
1534
2203
  }, z.core.$strip>;
2204
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1535
2205
  inference_path: z.ZodOptional<z.ZodString>;
1536
2206
  truncated: z.ZodOptional<z.ZodBoolean>;
1537
2207
  }, z.core.$strip>, z.ZodObject<{
@@ -1541,6 +2211,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1541
2211
  source: z.ZodOptional<z.ZodString>;
1542
2212
  }, z.core.$strip>>;
1543
2213
  inference_path: z.ZodOptional<z.ZodString>;
2214
+ }, z.core.$strip>, z.ZodObject<{
2215
+ coverage: z.ZodLiteral<"filtered">;
2216
+ filter: z.ZodString;
2217
+ dropped_count: z.ZodNumber;
2218
+ inference_path: z.ZodOptional<z.ZodString>;
1544
2219
  }, z.core.$strip>, z.ZodObject<{
1545
2220
  coverage: z.ZodLiteral<"not_loaded">;
1546
2221
  reason: z.ZodOptional<z.ZodString>;
@@ -1558,6 +2233,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1558
2233
  evidence: z.ZodArray<z.ZodObject<{
1559
2234
  pmid: z.ZodOptional<z.ZodString>;
1560
2235
  doi: z.ZodOptional<z.ZodString>;
2236
+ accession: z.ZodOptional<z.ZodString>;
1561
2237
  source: z.ZodString;
1562
2238
  predicate: z.ZodOptional<z.ZodString>;
1563
2239
  score: z.ZodOptional<z.ZodNumber>;
@@ -1575,6 +2251,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1575
2251
  }, z.core.$strip>>;
1576
2252
  }, z.core.$strip>>;
1577
2253
  }, z.core.$strip>;
2254
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1578
2255
  inference_path: z.ZodOptional<z.ZodString>;
1579
2256
  truncated: z.ZodOptional<z.ZodBoolean>;
1580
2257
  }, z.core.$strip>, z.ZodObject<{
@@ -1584,6 +2261,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1584
2261
  source: z.ZodOptional<z.ZodString>;
1585
2262
  }, z.core.$strip>>;
1586
2263
  inference_path: z.ZodOptional<z.ZodString>;
2264
+ }, z.core.$strip>, z.ZodObject<{
2265
+ coverage: z.ZodLiteral<"filtered">;
2266
+ filter: z.ZodString;
2267
+ dropped_count: z.ZodNumber;
2268
+ inference_path: z.ZodOptional<z.ZodString>;
1587
2269
  }, z.core.$strip>, z.ZodObject<{
1588
2270
  coverage: z.ZodLiteral<"not_loaded">;
1589
2271
  reason: z.ZodOptional<z.ZodString>;
@@ -1607,6 +2289,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1607
2289
  databases_queried: z.ZodArray<z.ZodString>;
1608
2290
  databases_skipped: z.ZodArray<z.ZodString>;
1609
2291
  }, z.core.$strip>;
2292
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1610
2293
  inference_path: z.ZodOptional<z.ZodString>;
1611
2294
  truncated: z.ZodOptional<z.ZodBoolean>;
1612
2295
  }, z.core.$strip>, z.ZodObject<{
@@ -1616,6 +2299,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1616
2299
  source: z.ZodOptional<z.ZodString>;
1617
2300
  }, z.core.$strip>>;
1618
2301
  inference_path: z.ZodOptional<z.ZodString>;
2302
+ }, z.core.$strip>, z.ZodObject<{
2303
+ coverage: z.ZodLiteral<"filtered">;
2304
+ filter: z.ZodString;
2305
+ dropped_count: z.ZodNumber;
2306
+ inference_path: z.ZodOptional<z.ZodString>;
1619
2307
  }, z.core.$strip>, z.ZodObject<{
1620
2308
  coverage: z.ZodLiteral<"not_loaded">;
1621
2309
  reason: z.ZodOptional<z.ZodString>;
@@ -1634,6 +2322,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1634
2322
  has_clinical_evidence: z.ZodBoolean;
1635
2323
  }, z.core.$strip>>;
1636
2324
  }, z.core.$strip>;
2325
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1637
2326
  inference_path: z.ZodOptional<z.ZodString>;
1638
2327
  truncated: z.ZodOptional<z.ZodBoolean>;
1639
2328
  }, z.core.$strip>, z.ZodObject<{
@@ -1643,40 +2332,105 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1643
2332
  source: z.ZodOptional<z.ZodString>;
1644
2333
  }, z.core.$strip>>;
1645
2334
  inference_path: z.ZodOptional<z.ZodString>;
2335
+ }, z.core.$strip>, z.ZodObject<{
2336
+ coverage: z.ZodLiteral<"filtered">;
2337
+ filter: z.ZodString;
2338
+ dropped_count: z.ZodNumber;
2339
+ inference_path: z.ZodOptional<z.ZodString>;
1646
2340
  }, z.core.$strip>, z.ZodObject<{
1647
2341
  coverage: z.ZodLiteral<"not_loaded">;
1648
2342
  reason: z.ZodOptional<z.ZodString>;
1649
2343
  }, z.core.$strip>], "coverage">;
1650
- preclinical: z.ZodObject<{
1651
- ko_phenotype: z.ZodDiscriminatedUnion<[z.ZodObject<{
1652
- coverage: z.ZodLiteral<"available">;
1653
- data: z.ZodObject<{
1654
- marker_symbol: z.ZodNullable<z.ZodString>;
1655
- viability: z.ZodNullable<z.ZodString>;
1656
- sex_dimorphism: z.ZodBoolean;
1657
- organ_systems_with_phenotype: z.ZodArray<z.ZodString>;
1658
- top_mp_terms: z.ZodArray<z.ZodString>;
1659
- total_phenotype_count: z.ZodNumber;
1660
- pre_weaning_lethal: z.ZodBoolean;
1661
- supporting_literature: z.ZodArray<z.ZodObject<{
1662
- pmid: z.ZodOptional<z.ZodString>;
1663
- doi: z.ZodOptional<z.ZodString>;
1664
- source: z.ZodString;
1665
- predicate: z.ZodOptional<z.ZodString>;
1666
- score: z.ZodOptional<z.ZodNumber>;
1667
- strength: z.ZodOptional<z.ZodString>;
1668
- is_human: z.ZodOptional<z.ZodBoolean>;
1669
- is_clinical: z.ZodOptional<z.ZodBoolean>;
1670
- excerpt: z.ZodOptional<z.ZodString>;
1671
- metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
1672
- regulatory_reference: z.ZodOptional<z.ZodObject<{
1673
- document: z.ZodString;
1674
- section: z.ZodOptional<z.ZodString>;
1675
- doc_id: z.ZodOptional<z.ZodString>;
1676
- doc_url: z.ZodOptional<z.ZodString>;
2344
+ normal_tissue_expression: z.ZodDiscriminatedUnion<[z.ZodObject<{
2345
+ coverage: z.ZodLiteral<"available">;
2346
+ data: z.ZodObject<{
2347
+ source: z.ZodEnum<{
2348
+ gtex: "gtex";
2349
+ hpa_consensus: "hpa_consensus";
2350
+ hpa_rna_tissue: "hpa_rna_tissue";
2351
+ }>;
2352
+ unit: z.ZodEnum<{
2353
+ tpm: "tpm";
2354
+ ntpm: "ntpm";
2355
+ consensus_normalized: "consensus_normalized";
2356
+ }>;
2357
+ normalization_notes: z.ZodString;
2358
+ rows: z.ZodArray<z.ZodObject<{
2359
+ tissue: z.ZodString;
2360
+ value: z.ZodNumber;
2361
+ percentile_rank: z.ZodOptional<z.ZodNumber>;
2362
+ }, z.core.$strip>>;
2363
+ }, z.core.$strip>;
2364
+ dropped_count: z.ZodOptional<z.ZodNumber>;
2365
+ inference_path: z.ZodOptional<z.ZodString>;
2366
+ truncated: z.ZodOptional<z.ZodBoolean>;
2367
+ }, z.core.$strip>, z.ZodObject<{
2368
+ coverage: z.ZodLiteral<"queried_no_data">;
2369
+ error: z.ZodOptional<z.ZodObject<{
2370
+ message: z.ZodString;
2371
+ source: z.ZodOptional<z.ZodString>;
2372
+ }, z.core.$strip>>;
2373
+ inference_path: z.ZodOptional<z.ZodString>;
2374
+ }, z.core.$strip>, z.ZodObject<{
2375
+ coverage: z.ZodLiteral<"filtered">;
2376
+ filter: z.ZodString;
2377
+ dropped_count: z.ZodNumber;
2378
+ inference_path: z.ZodOptional<z.ZodString>;
2379
+ }, z.core.$strip>, z.ZodObject<{
2380
+ coverage: z.ZodLiteral<"not_loaded">;
2381
+ reason: z.ZodOptional<z.ZodString>;
2382
+ }, z.core.$strip>], "coverage">;
2383
+ preclinical: z.ZodObject<{
2384
+ ko_phenotype: z.ZodDiscriminatedUnion<[z.ZodObject<{
2385
+ coverage: z.ZodLiteral<"available">;
2386
+ data: z.ZodObject<{
2387
+ marker_symbol: z.ZodNullable<z.ZodString>;
2388
+ viability: z.ZodNullable<z.ZodString>;
2389
+ sex_dimorphism: z.ZodBoolean;
2390
+ organ_systems_with_phenotype: z.ZodArray<z.ZodEnum<{
2391
+ hematologic: "hematologic";
2392
+ metabolic: "metabolic";
2393
+ immune: "immune";
2394
+ hepatic: "hepatic";
2395
+ musculoskeletal: "musculoskeletal";
2396
+ cns: "cns";
2397
+ renal: "renal";
2398
+ reproductive: "reproductive";
2399
+ respiratory: "respiratory";
2400
+ cardiac: "cardiac";
2401
+ vascular: "vascular";
2402
+ pns: "pns";
2403
+ gi: "gi";
2404
+ pancreas: "pancreas";
2405
+ endocrine_thyroid: "endocrine_thyroid";
2406
+ dermatologic: "dermatologic";
2407
+ ocular: "ocular";
2408
+ oncology: "oncology";
2409
+ }>>;
2410
+ top_mp_terms: z.ZodArray<z.ZodString>;
2411
+ total_phenotype_count: z.ZodNumber;
2412
+ pre_weaning_lethal: z.ZodBoolean;
2413
+ supporting_literature: z.ZodArray<z.ZodObject<{
2414
+ pmid: z.ZodOptional<z.ZodString>;
2415
+ doi: z.ZodOptional<z.ZodString>;
2416
+ accession: z.ZodOptional<z.ZodString>;
2417
+ source: z.ZodString;
2418
+ predicate: z.ZodOptional<z.ZodString>;
2419
+ score: z.ZodOptional<z.ZodNumber>;
2420
+ strength: z.ZodOptional<z.ZodString>;
2421
+ is_human: z.ZodOptional<z.ZodBoolean>;
2422
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
2423
+ excerpt: z.ZodOptional<z.ZodString>;
2424
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
2425
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
2426
+ document: z.ZodString;
2427
+ section: z.ZodOptional<z.ZodString>;
2428
+ doc_id: z.ZodOptional<z.ZodString>;
2429
+ doc_url: z.ZodOptional<z.ZodString>;
1677
2430
  }, z.core.$strip>>;
1678
2431
  }, z.core.$strip>>;
1679
2432
  }, z.core.$strip>;
2433
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1680
2434
  inference_path: z.ZodOptional<z.ZodString>;
1681
2435
  truncated: z.ZodOptional<z.ZodBoolean>;
1682
2436
  }, z.core.$strip>, z.ZodObject<{
@@ -1686,6 +2440,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1686
2440
  source: z.ZodOptional<z.ZodString>;
1687
2441
  }, z.core.$strip>>;
1688
2442
  inference_path: z.ZodOptional<z.ZodString>;
2443
+ }, z.core.$strip>, z.ZodObject<{
2444
+ coverage: z.ZodLiteral<"filtered">;
2445
+ filter: z.ZodString;
2446
+ dropped_count: z.ZodNumber;
2447
+ inference_path: z.ZodOptional<z.ZodString>;
1689
2448
  }, z.core.$strip>, z.ZodObject<{
1690
2449
  coverage: z.ZodLiteral<"not_loaded">;
1691
2450
  reason: z.ZodOptional<z.ZodString>;
@@ -1715,8 +2474,10 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1715
2474
  available: "available";
1716
2475
  queried_no_data: "queried_no_data";
1717
2476
  not_loaded: "not_loaded";
2477
+ filtered: "filtered";
1718
2478
  }>>;
1719
2479
  }, z.core.$strip>;
2480
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1720
2481
  inference_path: z.ZodOptional<z.ZodString>;
1721
2482
  truncated: z.ZodOptional<z.ZodBoolean>;
1722
2483
  }, z.core.$strip>, z.ZodObject<{
@@ -1726,6 +2487,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1726
2487
  source: z.ZodOptional<z.ZodString>;
1727
2488
  }, z.core.$strip>>;
1728
2489
  inference_path: z.ZodOptional<z.ZodString>;
2490
+ }, z.core.$strip>, z.ZodObject<{
2491
+ coverage: z.ZodLiteral<"filtered">;
2492
+ filter: z.ZodString;
2493
+ dropped_count: z.ZodNumber;
2494
+ inference_path: z.ZodOptional<z.ZodString>;
1729
2495
  }, z.core.$strip>, z.ZodObject<{
1730
2496
  coverage: z.ZodLiteral<"not_loaded">;
1731
2497
  reason: z.ZodOptional<z.ZodString>;
@@ -1744,6 +2510,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1744
2510
  text: z.ZodString;
1745
2511
  }, z.core.$strip>>;
1746
2512
  }, z.core.$strip>;
2513
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1747
2514
  inference_path: z.ZodOptional<z.ZodString>;
1748
2515
  truncated: z.ZodOptional<z.ZodBoolean>;
1749
2516
  }, z.core.$strip>, z.ZodObject<{
@@ -1753,6 +2520,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1753
2520
  source: z.ZodOptional<z.ZodString>;
1754
2521
  }, z.core.$strip>>;
1755
2522
  inference_path: z.ZodOptional<z.ZodString>;
2523
+ }, z.core.$strip>, z.ZodObject<{
2524
+ coverage: z.ZodLiteral<"filtered">;
2525
+ filter: z.ZodString;
2526
+ dropped_count: z.ZodNumber;
2527
+ inference_path: z.ZodOptional<z.ZodString>;
1756
2528
  }, z.core.$strip>, z.ZodObject<{
1757
2529
  coverage: z.ZodLiteral<"not_loaded">;
1758
2530
  reason: z.ZodOptional<z.ZodString>;
@@ -1770,6 +2542,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1770
2542
  total_claim_count: z.ZodNumber;
1771
2543
  truncated: z.ZodBoolean;
1772
2544
  }, z.core.$strip>;
2545
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1773
2546
  inference_path: z.ZodOptional<z.ZodString>;
1774
2547
  truncated: z.ZodOptional<z.ZodBoolean>;
1775
2548
  }, z.core.$strip>, z.ZodObject<{
@@ -1779,6 +2552,11 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1779
2552
  source: z.ZodOptional<z.ZodString>;
1780
2553
  }, z.core.$strip>>;
1781
2554
  inference_path: z.ZodOptional<z.ZodString>;
2555
+ }, z.core.$strip>, z.ZodObject<{
2556
+ coverage: z.ZodLiteral<"filtered">;
2557
+ filter: z.ZodString;
2558
+ dropped_count: z.ZodNumber;
2559
+ inference_path: z.ZodOptional<z.ZodString>;
1782
2560
  }, z.core.$strip>, z.ZodObject<{
1783
2561
  coverage: z.ZodLiteral<"not_loaded">;
1784
2562
  reason: z.ZodOptional<z.ZodString>;
@@ -1795,11 +2573,13 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1795
2573
  available: "available";
1796
2574
  queried_no_data: "queried_no_data";
1797
2575
  not_loaded: "not_loaded";
2576
+ filtered: "filtered";
1798
2577
  }>;
1799
2578
  literature: z.ZodEnum<{
1800
2579
  available: "available";
1801
2580
  queried_no_data: "queried_no_data";
1802
2581
  not_loaded: "not_loaded";
2582
+ filtered: "filtered";
1803
2583
  }>;
1804
2584
  per_species: z.ZodRecord<z.ZodString, z.ZodBoolean>;
1805
2585
  }, z.core.$strip>;
@@ -1814,6 +2594,7 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1814
2594
  year: z.ZodOptional<z.ZodNumber>;
1815
2595
  }, z.core.$strip>>;
1816
2596
  }, z.core.$strip>;
2597
+ dropped_count: z.ZodOptional<z.ZodNumber>;
1817
2598
  inference_path: z.ZodOptional<z.ZodString>;
1818
2599
  truncated: z.ZodOptional<z.ZodBoolean>;
1819
2600
  }, z.core.$strip>, z.ZodObject<{
@@ -1823,11 +2604,570 @@ export declare const Phase4OutputSchema: z.ZodObject<{
1823
2604
  source: z.ZodOptional<z.ZodString>;
1824
2605
  }, z.core.$strip>>;
1825
2606
  inference_path: z.ZodOptional<z.ZodString>;
2607
+ }, z.core.$strip>, z.ZodObject<{
2608
+ coverage: z.ZodLiteral<"filtered">;
2609
+ filter: z.ZodString;
2610
+ dropped_count: z.ZodNumber;
2611
+ inference_path: z.ZodOptional<z.ZodString>;
1826
2612
  }, z.core.$strip>, z.ZodObject<{
1827
2613
  coverage: z.ZodLiteral<"not_loaded">;
1828
2614
  reason: z.ZodOptional<z.ZodString>;
1829
2615
  }, z.core.$strip>], "coverage">;
1830
2616
  }, z.core.$strip>;
2617
+ analytics: z.ZodObject<{
2618
+ evidence_conflicts: z.ZodDiscriminatedUnion<[z.ZodObject<{
2619
+ coverage: z.ZodLiteral<"available">;
2620
+ data: z.ZodObject<{
2621
+ rows: z.ZodArray<z.ZodObject<{
2622
+ evidence_item_id: z.ZodString;
2623
+ predicate: z.ZodString;
2624
+ contradicting_predicates: z.ZodArray<z.ZodString>;
2625
+ surfaced_in_section: z.ZodString;
2626
+ evidence: z.ZodArray<z.ZodObject<{
2627
+ pmid: z.ZodOptional<z.ZodString>;
2628
+ doi: z.ZodOptional<z.ZodString>;
2629
+ accession: z.ZodOptional<z.ZodString>;
2630
+ source: z.ZodString;
2631
+ predicate: z.ZodOptional<z.ZodString>;
2632
+ score: z.ZodOptional<z.ZodNumber>;
2633
+ strength: z.ZodOptional<z.ZodString>;
2634
+ is_human: z.ZodOptional<z.ZodBoolean>;
2635
+ is_clinical: z.ZodOptional<z.ZodBoolean>;
2636
+ excerpt: z.ZodOptional<z.ZodString>;
2637
+ metadata: z.ZodOptional<z.ZodRecord<z.ZodString, z.ZodUnknown>>;
2638
+ regulatory_reference: z.ZodOptional<z.ZodObject<{
2639
+ document: z.ZodString;
2640
+ section: z.ZodOptional<z.ZodString>;
2641
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+ excerpt: z.ZodString;
3060
+ }, z.core.$strip>, z.ZodObject<{
3061
+ surface: z.ZodLiteral<"organ_claim_without_probe_pass">;
3062
+ excerpt: z.ZodString;
3063
+ bullet_category: z.ZodString;
3064
+ }, z.core.$strip>, z.ZodObject<{
3065
+ surface: z.ZodLiteral<"nct_wrong_class">;
3066
+ id: z.ZodString;
3067
+ excerpt: z.ZodString;
3068
+ }, z.core.$strip>, z.ZodObject<{
3069
+ surface: z.ZodLiteral<"pmid_not_in_key_papers">;
3070
+ id: z.ZodString;
3071
+ excerpt: z.ZodString;
3072
+ }, z.core.$strip>, z.ZodObject<{
3073
+ surface: z.ZodLiteral<"direction_mismatch">;
3074
+ pmid: z.ZodString;
3075
+ excerpt: z.ZodString;
3076
+ paper_conclusion_direction: z.ZodOptional<z.ZodEnum<{
3077
+ supports: "supports";
3078
+ contradicts: "contradicts";
3079
+ ambiguous: "ambiguous";
3080
+ }>>;
3081
+ }, z.core.$strip>, z.ZodObject<{
3082
+ surface: z.ZodLiteral<"abstract_unavailable">;
3083
+ pmid: z.ZodString;
3084
+ excerpt: z.ZodString;
3085
+ }, z.core.$strip>, z.ZodObject<{
3086
+ surface: z.ZodLiteral<"off_topic_citation">;
3087
+ pmid: z.ZodString;
3088
+ excerpt: z.ZodString;
3089
+ }, z.core.$strip>]>>;
3090
+ non_dossier_citations: z.ZodArray<z.ZodObject<{
3091
+ token: z.ZodString;
3092
+ source: z.ZodString;
3093
+ }, z.core.$strip>>;
3094
+ }, z.core.$strip>;
3095
+ dropped_count: z.ZodOptional<z.ZodNumber>;
3096
+ inference_path: z.ZodOptional<z.ZodString>;
3097
+ truncated: z.ZodOptional<z.ZodBoolean>;
3098
+ }, z.core.$strip>, z.ZodObject<{
3099
+ coverage: z.ZodLiteral<"queried_no_data">;
3100
+ error: z.ZodOptional<z.ZodObject<{
3101
+ message: z.ZodString;
3102
+ source: z.ZodOptional<z.ZodString>;
3103
+ }, z.core.$strip>>;
3104
+ inference_path: z.ZodOptional<z.ZodString>;
3105
+ }, z.core.$strip>, z.ZodObject<{
3106
+ coverage: z.ZodLiteral<"filtered">;
3107
+ filter: z.ZodString;
3108
+ dropped_count: z.ZodNumber;
3109
+ inference_path: z.ZodOptional<z.ZodString>;
3110
+ }, z.core.$strip>, z.ZodObject<{
3111
+ coverage: z.ZodLiteral<"not_loaded">;
3112
+ reason: z.ZodOptional<z.ZodString>;
3113
+ }, z.core.$strip>], "coverage">>;
3114
+ }, z.core.$strip>;
3115
+ executive_recommendation: z.ZodDiscriminatedUnion<[z.ZodObject<{
3116
+ coverage: z.ZodLiteral<"available">;
3117
+ data: z.ZodObject<{
3118
+ disposition: z.ZodEnum<{
3119
+ pursue: "pursue";
3120
+ conditional: "conditional";
3121
+ de_prioritize: "de_prioritize";
3122
+ insufficient_evidence: "insufficient_evidence";
3123
+ }>;
3124
+ confidence: z.ZodEnum<{
3125
+ high: "high";
3126
+ medium: "medium";
3127
+ low: "low";
3128
+ }>;
3129
+ rationale: z.ZodString;
3130
+ key_strengths: z.ZodDefault<z.ZodArray<z.ZodString>>;
3131
+ key_risks: z.ZodDefault<z.ZodArray<z.ZodString>>;
3132
+ key_risks_dropped: z.ZodOptional<z.ZodArray<z.ZodObject<{
3133
+ text: z.ZodString;
3134
+ reason: z.ZodString;
3135
+ cited_pmid: z.ZodOptional<z.ZodString>;
3136
+ }, z.core.$strip>>>;
3137
+ modality_choice: z.ZodObject<{
3138
+ modality: z.ZodString;
3139
+ rationale: z.ZodString;
3140
+ }, z.core.$strip>;
3141
+ coverage_qualifier: z.ZodObject<{
3142
+ sections_consulted: z.ZodDefault<z.ZodArray<z.ZodString>>;
3143
+ sections_unavailable: z.ZodDefault<z.ZodArray<z.ZodString>>;
3144
+ note: z.ZodString;
3145
+ unverified_bullets: z.ZodOptional<z.ZodArray<z.ZodObject<{
3146
+ text: z.ZodString;
3147
+ bullet_category: z.ZodString;
3148
+ surface: z.ZodLiteral<"organ_claim_without_probe_pass">;
3149
+ }, z.core.$strip>>>;
3150
+ }, z.core.$strip>;
3151
+ }, z.core.$strip>;
3152
+ dropped_count: z.ZodOptional<z.ZodNumber>;
3153
+ inference_path: z.ZodOptional<z.ZodString>;
3154
+ truncated: z.ZodOptional<z.ZodBoolean>;
3155
+ }, z.core.$strip>, z.ZodObject<{
3156
+ coverage: z.ZodLiteral<"queried_no_data">;
3157
+ error: z.ZodOptional<z.ZodObject<{
3158
+ message: z.ZodString;
3159
+ source: z.ZodOptional<z.ZodString>;
3160
+ }, z.core.$strip>>;
3161
+ inference_path: z.ZodOptional<z.ZodString>;
3162
+ }, z.core.$strip>, z.ZodObject<{
3163
+ coverage: z.ZodLiteral<"filtered">;
3164
+ filter: z.ZodString;
3165
+ dropped_count: z.ZodNumber;
3166
+ inference_path: z.ZodOptional<z.ZodString>;
3167
+ }, z.core.$strip>, z.ZodObject<{
3168
+ coverage: z.ZodLiteral<"not_loaded">;
3169
+ reason: z.ZodOptional<z.ZodString>;
3170
+ }, z.core.$strip>], "coverage">;
1831
3171
  generated_at: z.ZodString;
1832
3172
  }, z.core.$strip>;
1833
3173
  }, z.core.$strip>;
@@ -1835,7 +3175,7 @@ export type Phase4Output = z.infer<typeof Phase4OutputSchema>;
1835
3175
  export { Phase3BundleSchema };
1836
3176
  export type { Phase3Bundle };
1837
3177
  /**
1838
- * Run Phase 4 — assemble the v4 dossier body from the Phase-3 bundle.
1839
- * Deterministic over its inputs; safely cached on DBOS replay.
3178
+ * Run Phase 4 — assemble the dossier body from the Phase-3 bundle.
3179
+ * Safely cached on DBOS replay; the caller supplies the annotator seam.
1840
3180
  */
1841
- export declare function phase4Assemble(pool: Pool, phase3: Phase3Bundle): Promise<Phase4Output>;
3181
+ export declare function phase4Assemble(pool: Pool, phase3: Phase3Bundle, annotatorDeps?: ClinicalConsequenceAnnotatorDeps): Promise<Phase4Output>;