@gmod/cram 7.0.3 → 8.0.1

package/dist/cram-bundle.js

@@ -1,2 +1,2 @@
 /*! For license information please see cram-bundle.js.LICENSE.txt */
-(()=>{var A={6:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=e(r(141)),v=r(272),j=r(761);class f extends n.default{decode(A,t,r,e){const{blockContentId:n}=this.parameters,j=r[n];if(!j)throw new v.CramMalformedError(`no block found with content ID ${n}`);const f=e.externalBlocks.getCursor(n);return this._decodeByteArray(j,f)}_decodeByteArray(A,t){const r=A.content,{stopByte:e}=this.parameters,n=t.bytePosition;let v=t.bytePosition;for(;r[v]!==e&&v<r.length;){if(v===r.length)throw new j.CramBufferOverrunError("byteArrayStop reading beyond length of data buffer?");v+=1}return t.bytePosition=v+1,r.subarray(n,v)}}t.default=f},56:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=e(r(141)),v=r(761),j=r(272);class f extends n.default{constructor(A,t){if(super(A,t),this.codes={},this.codeBook={},this.sortedCodes=[],this.sortedValuesByBitCode=[],this.sortedBitCodes=[],this.sortedBitLengthsByBitCode=[],this.bitCodeToValue=[],!["byte","int"].includes(this.dataType))throw new TypeError(`${this.dataType} decoding not yet implemented by HUFFMAN_INT codec`);this.buildCodeBook(),this.buildCodes(),this.buildCaches(),0===this.sortedCodes[0].bitLength&&(this._decode=this._decodeZeroLengthCode)}buildCodeBook(){let A=new Array(this.parameters.numCodes);for(let t=0;t<this.parameters.numCodes;t++)A[t]={symbol:this.parameters.symbols[t],bitLength:this.parameters.bitLengths[t]};A=A.sort((A,t)=>A.bitLength-t.bitLength||A.symbol-t.symbol),this.codeBook={},A.forEach(A=>{this.codeBook[A.bitLength]||(this.codeBook[A.bitLength]=[]),this.codeBook[A.bitLength].push(A.symbol)})}buildCodes(){this.codes={};let A=0,t=-1;Object.entries(this.codeBook).forEach(([r,e])=>{const n=Number.parseInt(r,10);e.forEach(r=>{const e={bitLength:n,value:r,bitCode:0};t+=1;const v=n-A;if(t<<=v,e.bitCode=t,A+=v,function(A){let t=A-(A>>1)&1431655765;return t=(858993459&t)+(t>>2&858993459),16843009*(t+(t>>4)&252645135)>>24}(t)>n)throw new j.CramMalformedError("Symbol out of range");this.codes[r]=e})})}buildCaches(){this.sortedCodes=Object.values(this.codes).sort((A,t)=>A.bitLength-t.bitLength||A.bitCode-t.bitCode),this.sortedValuesByBitCode=this.sortedCodes.map(A=>A.value),this.sortedBitCodes=this.sortedCodes.map(A=>A.bitCode),this.sortedBitLengthsByBitCode=this.sortedCodes.map(A=>A.bitLength);const A=Math.max(...this.sortedBitCodes);this.bitCodeToValue=new Array(A+1).fill(-1);for(let A=0;A<this.sortedBitCodes.length;A+=1)this.bitCodeToValue[this.sortedCodes[A].bitCode]=A}decode(A,t,r,e){return this._decode(A,t,e.coreBlock)}_decodeZeroLengthCode(){return this.sortedCodes[0].value}_decode(A,t,r){const e=t.content;let n=0,f=0;for(let A=0;A<this.sortedCodes.length;A+=1){const t=this.sortedCodes[A].bitLength;f<<=t-n,f|=(0,v.getBits)(e,r,t-n),n=t;{const r=this.bitCodeToValue[f];if(r>-1&&this.sortedBitLengthsByBitCode[r]===t)return this.sortedValuesByBitCode[r];for(let r=A;this.sortedCodes[r+1].bitLength===t&&r<this.sortedCodes.length;r+=1)A+=1}}throw new j.CramMalformedError("Huffman symbol not found.")}}t.default=f},86:(A,t,r)=>{const e=r(308).A;A.exports=e,A.exports.default=e},111:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=e(r(141)),v=r(761),j=r(272);class f extends n.default{constructor(A,t){if(super(A,t),"int"!==this.dataType)throw new j.CramUnimplementedError(`${this.dataType} decoding not yet implemented by SUBEXP codec`)}decode(A,t,r,e){let n,j,f=0;for(;(0,v.getBits)(t.content,e.coreBlock,1);)f+=1;return 0===f?(n=this.parameters.K,j=(0,v.getBits)(t.content,e.coreBlock,n)):(n=f+this.parameters.K-1,j=1<<n|(0,v.getBits)(t.content,e.coreBlock,n)),j-this.parameters.offset}}t.default=f},128:(A,t)=>{"use strict";function r(A){return("object"==typeof A&&null!==A&&"message"in A?A.message:`${A}`).replace(/\.$/,"")}Object.defineProperty(t,"__esModule",{value:!0}),t.default=class{constructor(A,t={}){this.baseOverrides={},this.url=A;const r=t.fetch||globalThis.fetch.bind(globalThis);t.overrides&&(this.baseOverrides=t.overrides),this.fetchImplementation=r}async fetch(A,t){let e;try{e=await this.fetchImplementation(A,t)}catch(n){if(!`${n}`.includes("Failed to fetch"))throw new Error(`${r(n)} fetching ${A}`,{cause:n});console.warn(`generic-filehandle: refetching ${A} to attempt to work around chrome CORS header caching bug`);try{e=await this.fetchImplementation(A,{...t,cache:"reload"})}catch(t){throw new Error(`${r(t)} fetching ${A}`,{cause:t})}}return e}async read(A,t,r={}){if(0===A)return new Uint8Array(0);const{headers:e={},signal:n,overrides:v={}}=r;A<1/0?e.range=`bytes=${t}-${t+A-1}`:A===1/0&&0!==t&&(e.range=`bytes=${t}-`);const j=await this.fetch(this.url,{...this.baseOverrides,...v,headers:{...this.baseOverrides.headers,...v.headers,...e},method:"GET",redirect:"follow",mode:"cors",signal:n});if(!j.ok)throw new Error(`HTTP ${j.status} fetching ${this.url}`);if(200===j.status&&0===t||206===j.status){const t=j.headers.get("content-range"),r=/\/(\d+)$/.exec(t||"");r?.[1]&&(this._stat={size:parseInt(r[1],10)});const e=j.bytes?await j.bytes():new Uint8Array(await j.arrayBuffer());return e.byteLength<=A?e:e.subarray(0,A)}throw new Error(200===j.status?`${this.url} fetch returned status 200, expected 206`:`HTTP ${j.status} fetching ${this.url}`)}async readFile(A={}){let t,r;if("string"==typeof A)t=A,r={};else{t=A.encoding;const{encoding:e,...n}=A;r=n}const{headers:e={},signal:n,overrides:v={}}=r,j=await this.fetch(this.url,{...this.baseOverrides,...v,headers:{...this.baseOverrides.headers,...v.headers,...e},method:"GET",redirect:"follow",mode:"cors",signal:n});if(200!==j.status)throw new Error(`HTTP ${j.status} fetching ${this.url}`);if("utf8"===t)return j.text();if(t)throw new Error(`unsupported encoding: ${t}`);return j.bytes?j.bytes():new Uint8Array(await j.arrayBuffer())}async stat(){if(!this._stat&&(await this.read(10,0),!this._stat))throw new Error(`unable to determine size of file at ${this.url}`);return this._stat}async close(){}}},141:(A,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.default=class{constructor(A,t){this.parameters=A,this.dataType=t}}},151:A=>{var t={utf8:{stringToBytes:function(A){return t.bin.stringToBytes(unescape(encodeURIComponent(A)))},bytesToString:function(A){return decodeURIComponent(escape(t.bin.bytesToString(A)))}},bin:{stringToBytes:function(A){for(var t=[],r=0;r<A.length;r++)t.push(255&A.charCodeAt(r));return t},bytesToString:function(A){for(var t=[],r=0;r<A.length;r++)t.push(String.fromCharCode(A[r]));return t.join("")}}};A.exports=t},159:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0}),t.IndexedCramFile=t.CraiIndex=t.CramFile=t.CramRecord=void 0;var n=r(997);Object.defineProperty(t,"CramRecord",{enumerable:!0,get:function(){return n.CramRecord}}),Object.defineProperty(t,"CramFile",{enumerable:!0,get:function(){return e(n).default}});var v=r(638);Object.defineProperty(t,"CraiIndex",{enumerable:!0,get:function(){return e(v).default}});var j=r(223);Object.defineProperty(t,"IndexedCramFile",{enumerable:!0,get:function(){return e(j).default}})},166:function(A,t,r){"use strict";var e=this&&this.__createBinding||(Object.create?function(A,t,r,e){void 0===e&&(e=r);var n=Object.getOwnPropertyDescriptor(t,r);n&&!("get"in n?!t.__esModule:n.writable||n.configurable)||(n={enumerable:!0,get:function(){return t[r]}}),Object.defineProperty(A,e,n)}:function(A,t,r,e){void 0===e&&(e=r),A[e]=t[r]}),n=this&&this.__exportStar||function(A,t){for(var r in A)"default"===r||Object.prototype.hasOwnProperty.call(t,r)||e(t,A,r)},v=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0}),t.LocalFile=t.RemoteFile=t.BlobFile=void 0,n(r(492),t);var j=r(745);Object.defineProperty(t,"BlobFile",{enumerable:!0,get:function(){return v(j).default}});var f=r(128);Object.defineProperty(t,"RemoteFile",{enumerable:!0,get:function(){return v(f).default}}),t.LocalFile=class{readFile(){throw new Error("unimplemented")}read(){throw new Error("unimplemented")}close(){throw new Error("unimplemented")}}},169:(A,t,r)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.unzip=async function(A){return(0,e.zlib_uncompress)(A)};const e=r(282)},223:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=e(r(997)),v=r(272);t.default=class{constructor(A){if(this.cram=A.cram??new n.default({url:A.cramUrl,path:A.cramPath,filehandle:A.cramFilehandle,seqFetch:A.seqFetch,checkSequenceMD5:A.checkSequenceMD5,cacheSize:A.cacheSize}),!(this.cram instanceof n.default))throw new Error("invalid arguments: no cramfile");this.index=A.index}async getRecordsForRange(A,t,r,e={}){if(e.viewAsPairs=e.viewAsPairs||!1,e.pairAcrossChr=e.pairAcrossChr||!1,e.maxInsertSize=e.maxInsertSize||2e5,"string"==typeof A)throw new v.CramUnimplementedError("string sequence names not yet supported");const n=A,j=await this.index.getEntriesForRange(n,t,r),f=await Promise.all(j.map(e=>this.getRecordsInSlice(e,e=>e.sequenceId===A&&(void 0===e.lengthOnRef?e.alignmentStart>=t&&e.alignmentStart<=r:e.alignmentStart<=r&&e.alignmentStart+e.lengthOnRef-1>t))));let s=Array.prototype.concat(...f);if(e.viewAsPairs){const A={},t={};for(const r of s){const e=r.readName;if(void 0===e)throw new Error("readName undefined");const n=r.uniqueId;A[e]||(A[e]=0),A[e]+=1,t[n]=1}const r={};Object.entries(A).forEach(([A,t])=>{1===t&&(r[A]=!0)});const v=[];for(const A of s){const t=A.readName;if(void 0===t)throw new Error("readName undefined");if(r[t]&&A.mate&&(A.mate.sequenceId===n||e.pairAcrossChr)&&Math.abs(A.alignmentStart-A.mate.alignmentStart)<e.maxInsertSize){const t=this.index.getEntriesForRange(A.mate.sequenceId,A.mate.alignmentStart,A.mate.alignmentStart+1);v.push(t)}}const j=await Promise.all(v);let f=[];for(const A of j)f.push(...A);f=f.sort((A,t)=>A.toString().localeCompare(t.toString())).filter((A,t,r)=>!t||A.toString()!==r[t-1].toString());const i=[],b=[];for(const A of f){let e=this.cram.featureCache.get(A.toString());e||(e=this.getRecordsInSlice(A,()=>!0),this.cram.featureCache.set(A.toString(),e)),i.push(e);const n=e.then(A=>{const e=[];for(const n of A){if(void 0===n.readName)throw new Error("readName undefined");r[n.readName]&&!t[n.uniqueId]&&e.push(n)}return e});b.push(n)}const o=await Promise.all(b);if(o.length){const A=o.reduce((A,t)=>A.concat(t));s=s.concat(A)}}return s}getRecordsInSlice({containerStart:A,sliceStart:t,sliceBytes:r},e){return this.cram.getContainerAtPosition(A).getSlice(t,r).getRecords(e)}hasDataForReferenceSequence(A){return this.index.hasDataForReferenceSequence(A)}}},252:(A,t,r)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.xzDecompress=async function(A){j||await(v||(v=async function(){const A=e.xzdecompressWasm.replace("data:application/wasm;base64,",""),t=atob(A),r=t.length,n=new Uint8Array(r);for(let A=0;A<r;A++)n[A]=t.charCodeAt(A);const v=await WebAssembly.instantiate(n.buffer,{});j=v.instance}()));const t=new n(j),r=[];let s=0,i=!1;try{for(;;){if(t.mem32[2]===t.mem32[3])if(s<A.length){const r=Math.min(t.bufSize,A.length-s);t.supplyInput(A.subarray(s,s+r)),s+=r}else{if(i)throw new Error("XZ decompression error: unexpected end of input");t.supplyInput(f),i=!0}const e=t.getNextOutput();if(e.outChunk.length>0&&r.push(e.outChunk),t.mem32[5]=0,e.finished)break}if(1===r.length)return r[0];const e=r.reduce((A,t)=>A+t.length,0),n=new Uint8Array(e);let v=0;for(const A of r)n.set(A,v),v+=A.length;return n}finally{t.dispose()}};const e=r(820);class n{constructor(A){this.exports=A.exports,this.memory=this.exports.memory,this.ptr=this.exports.create_context(),this._refresh(),this.bufSize=this.mem32[0],this.inStart=this.mem32[1]-this.ptr,this.outStart=this.mem32[4]-this.ptr}supplyInput(A){this._refresh(),this.mem8.subarray(this.inStart,this.inStart+this.bufSize).set(A,0),this.exports.supply_input(this.ptr,A.byteLength)}getNextOutput(){const A=this.exports.get_next_output(this.ptr);if(this._refresh(),0!==A&&1!==A)throw new Error(`get_next_output failed with error code ${A}`);return{outChunk:this.mem8.slice(this.outStart,this.outStart+this.mem32[5]),finished:1===A}}dispose(){this.exports.destroy_context(this.ptr),this.exports=null}_refresh(){const A=this.memory.buffer;A!==this.mem8?.buffer&&(this.mem8=new Uint8Array(A,this.ptr),this.mem32=new Uint32Array(A,this.ptr))}}let v,j;const f=new Uint8Array(0)},272:(A,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CramArgumentError=t.CramSizeLimitError=t.CramMalformedError=t.CramUnimplementedError=t.CramError=void 0;class r extends Error{}t.CramError=r;class e extends Error{}t.CramUnimplementedError=e,t.CramMalformedError=class extends r{},t.CramSizeLimitError=class extends r{},t.CramArgumentError=class extends r{}},282:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0}),t.rans_uncompress=async function(A){if(0===A.length)return new Uint8Array(0);const t=await f(),r=s(t,A),e=t._malloc(4);try{const n=t._rans_uncompress(r,A.length,e);if(0===n)throw new Error("rans_uncompress failed");const v=t.getValue(e,"i32"),j=i(t,n,v);return t._free(n),j}finally{t._free(r),t._free(e)}},t.r4x16_uncompress=async function(A){const t=await f(),r=s(t,A),e=t._malloc(4);try{const n=t._rans_uncompress_4x16(r,A.length,e);if(0===n)throw new Error("rans_uncompress_4x16 failed");const v=t.getValue(e,"i32"),j=i(t,n,v);return t._free(n),j}finally{t._free(r),t._free(e)}},t.arith_uncompress=async function(A){const t=await f(),r=s(t,A),e=t._malloc(4);try{const n=t._arith_uncompress(r,A.length,e);if(0===n)throw new Error("arith_uncompress failed");const v=t.getValue(e,"i32"),j=i(t,n,v);return t._free(n),j}finally{t._free(r),t._free(e)}},t.fqzcomp_uncompress=async function(A){const t=await f(),r=s(t,A),e=t._malloc(4),n=t._malloc(4);try{const v=t._fqz_decompress(r,A.length,e,n);if(0===v)throw new Error("fqz_decompress failed");const j=t.getValue(e,"i32"),f=i(t,v,j);return t._free(v),f}finally{t._free(r),t._free(e),t._free(n)}},t.zlib_uncompress=async function(A){if(0===A.length)return new Uint8Array(0);const t=await f(),r=s(t,A),e=t._malloc(4);try{const n=t._zlib_uncompress(r,A.length,e);if(0===n)throw new Error("zlib_uncompress failed");const v=t.getValue(e,"i32"),j=i(t,n,v);return t._free(n),j}finally{t._free(r),t._free(e)}},t.bz2_uncompress=async function(A,t){if(0===A.length)return new Uint8Array(0);const r=await f(),e=s(r,A),n=r._malloc(4);try{const v=r._bz2_uncompress(e,A.length,t,n);if(0===v)throw new Error("bz2_uncompress failed");const j=r.getValue(n,"i32"),f=i(r,v,j);return r._free(v),f}finally{r._free(e),r._free(n)}},t.tok3_uncompress=async function(A){const t=await f(),r=s(t,A),e=t._malloc(4);try{const n=t._tok3_decode_names(r,A.length,e);if(0===n)throw new 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A=function(A,t){if(!A.lengthOnRef&&!A.readLength)return null;if(A.isUnknownBases())return null;const r=A.alignmentStart-t.start;if(!A.readFeatures)return t.seq.slice(r,r+(A.lengthOnRef||0)).toUpperCase();let e="",n=r,v=0;for(;e.length<A.readLength;)if(v<A.readFeatures.length){const r=A.readFeatures[v];if("Q"===r.code||"q"===r.code)v+=1;else if(r.pos===e.length+1)if(v+=1,"b"===r.code){const A=r.data;e+=A,n+=A.length}else"B"===r.code?(e+=r.data[0],n+=1):"X"===r.code?(e+=r.sub,n+=1):"I"===r.code?e+=r.data:"D"===r.code?n+=r.data:"i"===r.code?e+=r.data:"N"===r.code?n+=r.data:"S"===r.code?e+=r.data:"P"===r.code||r.code;else if(v<A.readFeatures.length){const A=t.seq.slice(n,n+r.pos-e.length-1);e+=A,n+=A.length}}else{const r=t.seq.slice(n,n+A.readLength-e.length);e+=r,n+=r.length}return e.toUpperCase()}(this,this._refRegion);A&&(this.readBases=A)}return this.readBases}getPairOrientation(){if(!this.isSegmentUnmapped()&&this.isPaired()&&!this.isMateUnmapped()&&this.mate&&this.sequenceId===this.mate.sequenceId){const A=this.isReverseComplemented()?"R":"F",t=this.isMateReverseComplemented()?"R":"F";let r=" ",e=" ";this.isRead1()?(r="1",e="2"):this.isRead2()&&(r="2",e="1");const n=[];let v=this.templateLength||this.templateSize;if(void 0===v)throw new Error("One of templateSize and templateLength must be set");return this.alignmentStart>this.mate.alignmentStart&&v>0&&(v=-v),v>0?(n[0]=A,n[1]=r,n[2]=t,n[3]=e):(n[2]=A,n[3]=r,n[0]=t,n[1]=e),n.join("")}return null}addReferenceSequence(A,t){this.readFeatures&&this.readFeatures.forEach(r=>{"X"===r.code&&function(A,t,r,e){const n=e.refPos-t.start,j=t.seq.charAt(n);j&&(e.ref=j);let f=v[j];void 0===f&&(f=4);const s=r.substitutionMatrix[f][e.data];s&&(e.sub=s)}(0,A,t,r)}),!this.readBases&&A.start<=this.alignmentStart&&A.end>=this.alignmentStart+(this.lengthOnRef||this.readLength)-1&&(this._refRegion=A)}toJSON(){const A={};return Object.keys(this).forEach(t=>{t.startsWith("_")||(A[t]=this[t])}),A.readBases=this.getReadBases(),A}}},492:(A,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0})},500:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=r(272),v=r(761),j=e(r(588)),f=e(r(685)),s=e(r(480)),i=r(580),b=r(549);function o(A,t,r,e){const v=!!(e.mate||void 0!==e.mateRecordNumber&&e.mateRecordNumber!==t);r.readName||(r.readName=String(r.uniqueId),e.readName=r.readName),r.mate={sequenceId:e.sequenceId,alignmentStart:e.alignmentStart,uniqueId:e.uniqueId},e.readName&&(r.mate.readName=e.readName),e.mate||void 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file seems malformed");A.templateLength=f})}(A,0,r):function(A,t){const r=Math.min(A.alignmentStart,t.alignmentStart),e=Math.max(A.alignmentStart+A.readLength-1,t.alignmentStart+t.readLength-1)-r+1;A.templateLength=e,t.templateLength=e}(r,e)),r.mateRecordNumber=void 0}class a{constructor(A,t,r){this.container=A,this.containerPosition=t,this.sliceSize=r,this.file=A.file}async getHeader(){const{majorVersion:A}=await this.file.getDefinition(),t=(0,i.getSectionParsers)(A),r=await this.container.getHeader(),e=await this.file.readBlock(r._endPosition+this.containerPosition);if("MAPPED_SLICE_HEADER"===e.contentType){const A=(0,b.parseItem)(e.content,t.cramMappedSliceHeader.parser,0,r._endPosition);return{...e,parsedContent:A}}if("UNMAPPED_SLICE_HEADER"===e.contentType){const A=(0,b.parseItem)(e.content,t.cramUnmappedSliceHeader.parser,0,r._endPosition);return{...e,parsedContent:A}}throw new n.CramMalformedError(`error reading slice header block, invalid content type ${e.contentType}`)}async getBlocks(){const A=await this.getHeader();let t=A._endPosition;const r=new Array(A.parsedContent.numBlocks);for(let A=0;A<r.length;A++){const e=await this.file.readBlock(t);r[A]=e,t=r[A]._endPosition}return r}async getCoreDataBlock(){return(await this.getBlocks())[0]}async _getBlocksContentIdIndex(){const A=await this.getBlocks(),t={};return A.forEach(A=>{"EXTERNAL_DATA"===A.contentType&&(t[A.contentId]=A)}),t}async getBlockByContentId(A){return(await this._getBlocksContentIdIndex())[A]}async getReferenceRegion(){const A=new TextDecoder("utf8"),t=(await this.getHeader()).parsedContent;if(!(0,i.isMappedSliceHeader)(t))throw new Error("slice header not mapped");if(t.refSeqId<0)return;const r=await this.container.getCompressionScheme();if(void 0===r)throw new Error("compression scheme undefined");if(t.refBaseBlockId>=0){const r=await this.getBlockByContentId(t.refBaseBlockId);if(!r)throw new n.CramMalformedError("embedded reference specified, but reference block does not exist");return{seq:A.decode(r.data),start:t.refSeqStart,end:t.refSeqStart+t.refSeqSpan-1,span:t.refSeqSpan}}if(r.referenceRequired||this.file.fetchReferenceSequenceCallback){if(!this.file.fetchReferenceSequenceCallback)throw new Error("reference sequence not embedded, and seqFetch callback not provided, cannot fetch reference sequence");const A=await this.file.fetchReferenceSequenceCallback(t.refSeqId,t.refSeqStart,t.refSeqStart+t.refSeqSpan-1);if(A.length!==t.refSeqSpan)throw new n.CramArgumentError("seqFetch callback returned a reference sequence of the wrong length");return{seq:A,start:t.refSeqStart,end:t.refSeqStart+t.refSeqSpan-1,span:t.refSeqSpan}}}getAllRecords(){return this.getRecords(()=>!0)}async _fetchRecords(){const{majorVersion:A}=await this.file.getDefinition(),t=await this.container.getCompressionScheme();if(void 0===t)throw new Error("compression scheme undefined");const r=await this.getHeader(),e=await this._getBlocksContentIdIndex();if(A>1&&this.file.options.checkSequenceMD5&&(0,i.isMappedSliceHeader)(r.parsedContent)&&r.parsedContent.refSeqId>=0&&"0000000000000000"!==r.parsedContent.md5?.join("")){const A=await this.getReferenceRegion();if(A){const{seq:t,start:e,end:v}=A,j=(0,b.sequenceMD5)(t),f=r.parsedContent.md5?.map(A=>(A<16?"0":"")+A.toString(16)).join("");if(j!==f)throw new n.CramMalformedError(`MD5 checksum reference mismatch for ref ${r.parsedContent.refSeqId} pos ${e}..${v}. recorded MD5: ${f}, calculated MD5: ${j}`)}}const j=await this.getCoreDataBlock(),a={lastAlignmentStart:(0,i.isMappedSliceHeader)(r.parsedContent)?r.parsedContent.refSeqStart:0,coreBlock:{bitPosition:7,bytePosition:0},externalBlocks:{map:new Map,getCursor(A){let t=this.map.get(A);return void 0===t&&(t={bitPosition:7,bytePosition:0},this.map.set(A,t)),t}}},g=new Map,c=A=>{let r=g.get(A);if(void 0===r){if(r=t.getCodecForDataSeries(A),!r)throw new n.CramMalformedError(`no codec defined for ${A} data 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Decoded ${t} of ${e} expected records. Buffer overrun suggests either: (1) file is truncated/corrupted, (2) compression scheme is incorrect, or (3) there's a bug in the decoder. Original error: ${A.message}`)}throw A}for(let A=0;A<I.length;A+=1){const t=I[A];if(t){const{mateRecordNumber:r}=t;void 0!==r&&r>=0&&I[r]&&o(I,A,t,I[r])}}return I}async getRecords(A){const t=this.container.filePosition+this.containerPosition;let r=this.file.featureCache.get(t.toString());r||(r=this._fetchRecords(),this.file.featureCache.set(t.toString(),r));const e=(await r).filter(A);if(e.length&&this.file.fetchReferenceSequenceCallback){const A=await this.getHeader();if((0,i.isMappedSliceHeader)(A.parsedContent)&&(A.parsedContent.refSeqId>=0||-2===A.parsedContent.refSeqId)){const t=A.parsedContent.refSeqId>=0?A.parsedContent.refSeqId:void 0,r=await this.container.getCompressionScheme();if(void 0===r)throw new Error("compression scheme undefined");const n={};for(const A of e){const r=void 0!==t?t:A.sequenceId;let e=n[r];e||(e={id:r,start:A.alignmentStart,end:Number.NEGATIVE_INFINITY,seq:null},n[r]=e);const 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Error("Not a CRAM file, does not match magic string");if(2!==r.majorVersion&&3!==r.majorVersion)throw new b.CramUnimplementedError(`CRAM version ${r.majorVersion} not supported`);return r}async getSamHeader(){const A=await this.getContainerById(0);if(!A)throw new b.CramMalformedError("file contains no containers");const t=(await A.getFirstBlock()).content,r=new DataView(t.buffer).getInt32(0,!0),e=new TextDecoder("utf8").decode(t.subarray(4,4+r));return this.header=e,(0,g.parseHeaderText)(e)}async getHeaderText(){return await this.getSamHeader(),this.header}async getContainerById(A){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=(0,E.getSectionParsers)(A)}let t,r=this._sectionParsers.cramFileDefinition.maxLength;for(let e=0;e<=A;e++){t=this.getContainerAtPosition(r);const A=await t.getHeader();if(0===e){r=A._endPosition;for(let t=0;t<A.numBlocks;t++)r=(await this.readBlock(r))._endPosition}else r+=A._size+A.length}return t}async checkCrc32(A,t,r,e){const n=await this.file.read(t,A),v=(0,s.default)(n)>>>0;if(v!==r)throw new b.CramMalformedError(`crc mismatch in ${e}: recorded CRC32 = ${r}, but calculated CRC32 = ${v}`)}async containerCount(){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=(0,E.getSectionParsers)(A)}let A=0,t=this._sectionParsers.cramFileDefinition.maxLength;try{for(;;){const r=await this.getContainerAtPosition(t).getHeader();if(0===A){t=r._endPosition;for(let A=0;A<r.numBlocks;A++)t=(await this.readBlock(t))._endPosition}else t+=r._size+r.length;A+=1}}catch(t){A--}return A}getContainerAtPosition(A){return new l.default(this,A)}async readBlockHeader(A){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=(0,E.getSectionParsers)(A)}const{cramBlockHeader:t}=this._sectionParsers,r=await this.file.read(t.maxLength,A);return(0,c.parseItem)(r,t.parser,0,A)}async _parseSection(A,t,r=A.maxLength,e){const 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r=this._sectionParsers,e=await this.readBlockHeader(A),n=e._endPosition,v=await this.file.read(e.compressedSize,n),j="raw"!==e.compressionMethod?await this._uncompress(e.compressionMethod,v,e.uncompressedSize):v,f={...e,_endPosition:n,contentPosition:n,content:j};if(t>=3){const t=await this._parseSection(r.cramBlockCrc32,n+e.compressedSize);f.crc32=t.crc32,this.validateChecksums&&await this.checkCrc32(A,e._size+e.compressedSize,t.crc32,"block data"),f._endPosition=t._endPosition,f._size=f.compressedSize+r.cramBlockCrc32.maxLength}else f._endPosition=n+f.compressedSize,f._size=f.compressedSize;return f}}t.default=d,"getDefinition getSectionParsers getSamHeader".split(" ").forEach(A=>{(0,c.tinyMemoize)(d,A)})},761:(A,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CramBufferOverrunError=void 0,t.getBits=function(A,t,e){let n=0;if(t.bytePosition+(7-t.bitPosition+e)/8>A.length)throw new r("read error during decoding. the file seems to be truncated.");for(let r=e;r;r--)n<<=1,n|=A[t.bytePosition]>>t.bitPosition&1,t.bitPosition-=1,t.bitPosition<0&&(t.bytePosition+=1),t.bitPosition&=7;return n};class r extends Error{}t.CramBufferOverrunError=r},807:function(A,t,r){"use strict";var e=this&&this.__importDefault||function(A){return A&&A.__esModule?A:{default:A}};Object.defineProperty(t,"__esModule",{value:!0});const n=e(r(141)),v=r(761),j=r(272);class f extends n.default{constructor(A,t){if(super(A,t),"int"!==this.dataType)throw new j.CramUnimplementedError(`${this.dataType} decoding not yet implemented by BETA codec`)}decode(A,t,r,e){return(0,v.getBits)(t.content,e.coreBlock,this.parameters.length)-this.parameters.offset}}t.default=f},820:(A,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.xzdecompressWasm=void 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console.warn("majorVersion is <2, recordCounter set to 0");const[a,g]=fA(t,r);r+=g;const[I,c]=fA(t,r);r+=c;const E=[];for(let A=0;A<I;A++){const[A,e]=fA(t,r);r+=e,E.push(A)}const[C,l]=fA(t,r);let h;return r+=l,A>=2&&(h=[...t.subarray(r,r+16)],r+=16),{value:{md5:h,numBlocks:a,numRecords:b,numContentIds:I,refSeqSpan:f,refSeqId:e,refSeqStart:n,recordCounter:o,refBaseBlockId:C,contentIds:E},offset:r}},maxLength:A=>60+5*A}}function dA(A,t){const r=A,e=new DataView(r.buffer,r.byteOffset,r.length),[v,n]=fA(A,t);t+=n;const[j,f]=fA(A,t);t+=f;const s={};if(0===v);else if(1===v){const[r,e]=fA(A,t);s.blockContentId=r,t+=e}else if(2===v){const[r,e]=fA(A,t);s.offset=r,t+=e;const[v,n]=fA(A,t);s.M=v,t+=n}else if(3===v){const r=fA(A,t),e=r[0];t+=r[1];const v=[];for(let r=0;r<e;r++){const r=fA(A,t);v.push(r[0]),t+=r[1]}s.symbols=v;const n=fA(A,t),j=r[0];s.numLengths=j,s.numCodes=e,s.numLengths=j,t+=n[1];const f=[];for(let r=0;r<j;r++){const r=fA(A,t);t+=r[1],f.push(r[0])}s.bitLengths=f}else if(4===v){const{value:r,offset:e}=dA(A,t);s.lengthsEncoding=r,t=e;const{value:v,offset:n}=dA(A,t);s.valuesEncoding=v,t=n}else if(5===v){s.stopByte=e.getUint8(t),t+=1;const[r,v]=fA(A,t);s.blockContentId=r,t+=v}else if(6===v){const[r,e]=fA(A,t);s.offset=r,t+=e;const[v,n]=fA(A,t);s.length=v,t+=n}else if(7===v){const[r,e]=fA(A,t);s.offset=r,t+=e;const[v,n]=fA(A,t);s.K=v,t+=n}else if(8===v){const[r,e]=fA(A,t);s.offset=r,t+=e;const[v,n]=fA(A,t);s.log2m=v,t+=n}else{if(9!==v)throw new Error(`unknown codecId ${v}`);{const[r,e]=fA(A,t);s.offset=r,t+=e}}return{value:{codecId:v,parametersBytes:j,parameters:s},offset:t}}function kA(){return{parser:(A,t)=>{const[r,e]=fA(A,t);t+=e;const[v,n]=fA(A,t);t+=n;const j=[];for(let r=0;r<v;r++){const r=String.fromCharCode(A[t])+String.fromCharCode(A[t+1]);t+=2;const{value:e,offset:v}=dA(A,t);t=v,j.push({key:r,value:e})}return{value:{mapSize:r,ents:j,mapCount:v},offset:t}}}}function BA(){return{parser:(A,t)=>{const[r,e]=fA(A,t);t+=e;const[v,n]=fA(A,t);t+=n;const j=[];for(let r=0;r<v;r++){const[r,e]=fA(A,t);t+=e;const v=String.fromCharCode(r>>16&255)+String.fromCharCode(r>>8&255)+String.fromCharCode(255&r),{value:n,offset:f}=dA(A,t);t=f,j.push({key:v,value:n})}return{value:{mapSize:r,ents:j,mapCount:v},offset:t}}}}function qA(A){let t=4;return t+=20,t+=9,t+=9,t+=10,{maxLength:52,parser:(t,r)=>{const e=t,v=new DataView(e.buffer,e.byteOffset,e.length).getInt32(r,!0);r+=4;const[n,j]=fA(t,r);r+=j;const[f,s]=fA(t,r);r+=s;const[b,i]=fA(t,r);r+=i;const[o,a]=fA(t,r);r+=a;let g,I=0;if(A>=3){const[A,e]=sA(t,r);I=A,r+=e}else if(2===A){const[A,e]=fA(t,r);I=A,r+=e}else console.warn("setting recordCounter=0");if(A>1){const[A,e]=sA(t,r);g=A,r+=e}const[c,E]=fA(t,r);r+=E;const[C,l]=fA(t,r);return{value:{length:v,refSeqId:n,refSeqStart:f,alignmentSpan:b,numBlocks:c,numLandmarks:C,numBases:g,recordCounter:I,numRecords:o},offset:r+=l}}}}function QA(A){return{parser:(t,r)=>{const e=t,v=new DataView(e.buffer,e.byteOffset,e.length),[n,j]=fA(t,r);r+=j;const f=[];for(let A=0;A<n;A++){const[A,e]=fA(t,r);r+=e,f.push(A)}let s;return A>=3&&(s=v.getUint32(r,!0),r+=4),{value:{...void 0===s?{}:{crc32:s},numLandmarks:n,landmarks:f},offset:r}},maxLength:A=>5+5*A+4}}function uA(A){return{cramFileDefinition:gA(),cramBlockHeader:{parser:(A,t=0)=>{const r=A,e=new DataView(r.buffer,r.byteOffset,r.length);let v=0;const n=e.getUint8(v),j=["raw","gzip","bzip2","lzma","rans","rans4x16","arith","fqzcomp","tok3"][n];if(!j)throw new Error(`compression method number ${n} not implemented`);v+=1;const f=e.getUint8(v),s=["FILE_HEADER","COMPRESSION_HEADER","MAPPED_SLICE_HEADER","UNMAPPED_SLICE_HEADER","EXTERNAL_DATA","CORE_DATA"][f];if(!s)throw new Error(`invalid block content type id ${f}`);v+=1;const[b,i]=fA(A,v);v+=i;const[o,a]=fA(A,v);v+=a;const[g,I]=fA(A,v);return v+=I,{offset:v,value:{uncompressedSize:g,compressedSize:o,contentId:b,contentType:s,compressionMethod:j}}},maxLength:17},cramBlockCrc32:{parser:(A,t)=>{const r=A,e=new DataView(r.buffer,r.byteOffset,r.length).getUint32(t,!0);return{offset:t+=4,value:{crc32:e}}},maxLength:4},cramDataSeriesEncodingMap:kA(),cramTagEncodingMap:BA(),cramCompressionHeader:{parser:(A,t)=>{const{value:r,offset:e}=((A,t)=>{const r=A,e=new DataView(r.buffer,r.byteOffset,r.length),[v,n]=fA(A,t);t+=n;const[j,f]=fA(A,t);t+=f;const s=[];for(let r=0;r<j;r++){const r=String.fromCharCode(A[t])+String.fromCharCode(A[t+1]);if(t+=2,"MI"===r||"UI"===r||"PI"===r||"RN"===r||"AP"===r||"RR"===r)s.push({key:r,value:!!e.getUint8(t)}),t+=1;else if("SM"===r)s.push({key:r,value:[e.getUint8(t),e.getUint8(t+1),e.getUint8(t+2),e.getUint8(t+3),e.getUint8(t+4)]}),t+=5;else{if("TD"!==r)throw new Error(`unknown key ${r}`);{const{offset:e,value:v}=cA().parser(A,t);s.push({key:r,value:v.ents}),t=e}}}return{value:{mapSize:v,mapCount:j,ents:s},offset:t}})(A,t);t=e;const{value:v,offset:n}=kA().parser(A,t);t=n;const{value:j,offset:f}=BA().parser(A,t);return t=f,{value:{dataSeriesEncoding:EA(v),preservation:EA(r),tagEncoding:EA(j)},offset:t}}},cramEncoding:{parser:(A,t)=>dA(A,t)},cramUnmappedSliceHeader:lA(A),cramMappedSliceHeader:hA(A),cramContainerHeader1:qA(A),cramContainerHeader2:QA(A)}}const xA=new TextDecoder("latin1");function mA(A){let t=0;for(;t<A.length&&0!==A[t];)t++;return xA.decode(A.subarray(0,t))}function wA(A,t){if("Z"===A)return mA(t);if("A"===A)return String.fromCharCode(t[0]);if("I"===A)return new Uint32Array(t.buffer)[0];if("i"===A)return new Int32Array(t.buffer)[0];if("s"===A)return new Int16Array(t.buffer)[0];if("S"===A)return new Uint16Array(t.buffer)[0];if("c"===A)return new Int8Array(t.buffer)[0];if("C"===A)return t[0];if("f"===A)return new Float32Array(t.buffer)[0];if("H"===A)return Number.parseInt(mA(t).replace(/^0x/,""),16);if("B"===A)return function(A){const t=String.fromCharCode(A[0]),r=new DataView(A.buffer).getUint32(1,!0),e=new Array(r);if(A=A.slice(5),"c"===t){const t=new Int8Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else if("C"===t){const t=new Uint8Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else if("s"===t){const t=new Int16Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else if("S"===t){const t=new Uint16Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else if("i"===t){const t=new Int32Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else if("I"===t){const t=new Uint32Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}else{if("f"!==t)throw new Error(`unknown type: ${t}`);{const t=new Float32Array(A.buffer);for(let A=0;A<r;A++)e[A]=t[A]}}return e}(t);throw new U(`Unrecognized tag type ${A}`)}const NA={B:["character","BA"],X:["number","BS"],D:["number","DL"],I:["string","IN"],i:["character","BA"],b:["string","BB"],q:["numArray","QQ"],Q:["number","QS"],H:["number","HC"],P:["number","PD"],N:["number","RS"]},pA={...NA,S:["string","IN"]},yA={...NA,S:["string","SC"]},DA={B:["number","QS"]};function SA(A,t,r,e,v,n,j,f,s,b,i){let o=t("BF");const a=t("CF");if(!CA(e.parsedContent))throw new Error("slice header not mapped");const g=f>1&&-2===e.parsedContent.refSeqId?t("RI"):e.parsedContent.refSeqId,I=t("RL");let c=t("AP");r.APdelta&&(c+=j.lastAlignmentStart),j.lastAlignmentStart=c;const E=t("RG");let C,l,h,d;if(r.readNamesIncluded&&(C=mA(t("RN"))),q.isDetached(a)){const A=t("MF");let e;r.readNamesIncluded||(e=mA(t("RN")),C=e);const v=t("NS"),n=t("NP");(A||v>-1)&&(l={mateFlags:A,mateSequenceId:v,mateAlignmentStart:n,mateReadName:e}),h=t("TS"),Q.isUnmapped(A)&&(o=B.setMateUnmapped(o)),Q.isOnNegativeStrand(A)&&(o=B.setMateReverseComplemented(o))}else q.isWithMateDownstream(a)&&(d=t("NF")+s+1);const k=t("TL");if(k<0)throw new U("invalid TL index");const u={},x=r.getTagNames(k),m=x.length,w=!1!==b?.decodeTags;for(let t=0;t<m;t++){const e=x[t],f=r.getCodecForTag(e).decode(A,v,n,j);if(w){const A=e[0]+e[1],t=e[2];u[A]=void 0===f?void 0:"number"==typeof f?f:wA(t,f)}}let N,p,y,D,S;if(B.isSegmentUnmapped(o))if(q.isDecodeSequenceAsStar(a))S=null,D=null;else{const A=i?.("BA",I);if(A)S=xA.decode(A);else{let A="";for(let r=0;r<I;r++)A+=String.fromCharCode(t("BA"));S=A}if(q.isPreservingQualityScores(a)){const A=i?.("QS",I);if(A)D=A;else{D=new Uint8Array(I);for(let A=0;A<I;A++)D[A]=t("QS")}}}else{const A=t("FN");if(A&&(N=function(A,t,r,e,v){let n=0,j=A-1;const f=new Array(t),s=v>1?yA:pA;function b([A,t]){const e=r(t);return"character"===A?String.fromCharCode(e):"string"===A?xA.decode(e):"numArray"===A?Array.from(e):e}for(let A=0;A<t;A++){const t=String.fromCharCode(r("FC")),e=r("FP"),v=s[t];if(!v)throw new U(`invalid read feature code "${t}"`);let i=b(v);const o=DA[t];o&&(i=[i,b(o)]),n+=e;const a=n;j+=e;const g=j;"D"===t||"N"===t?j+=i:"I"===t||"S"===t?j-=i.length:"i"===t&&(j-=1),f[A]={code:t,pos:a,refPos:g,data:i}}return f}(c,A,t,0,f)),p=I,N)for(const{code:A,data:t}of N)"D"===A||"N"===A?p+=t:"I"===A||"S"===A?p-=t.length:"i"===A&&(p-=1);if(Number.isNaN(p)&&(console.warn(`${C||`${g}:${c}`} record has invalid read features`),p=I),y=t("MQ"),q.isPreservingQualityScores(a)){const A=i?.("QS",I);if(A)D=A;else{D=new Uint8Array(I);for(let A=0;A<I;A++)D[A]=t("QS")}}}return{readLength:I,sequenceId:g,cramFlags:a,flags:o,alignmentStart:c,readGroupId:E,readName:C,mateToUse:l,templateSize:h,mateRecordNumber:d,readFeatures:N,lengthOnRef:p,mappingQuality:y,qualityScores:D,readBases:S,tags:u}}class GA{constructor(A,t){this.parameters=A,this.dataType=t}}class FA extends GA{constructor(A,t){if(super(A,t),"int"!==this.dataType&&"byte"!==this.dataType)throw new T(`${this.dataType} decoding not yet implemented by EXTERNAL codec`)}decode(A,t,r,e){const{blockContentId:v}=this.parameters,n=r[v];if(!n)return;const j=e.externalBlocks.getCursor(v);if("int"===this.dataType){const[A,t]=fA(n.content,j.bytePosition);return j.bytePosition+=t,A}if(j.bytePosition>=n.content.length)throw new aA("attempted to read beyond end of block. this file seems truncated.");return n.content[j.bytePosition++]}getBytesSubarray(A,t,r){const{blockContentId:e}=this.parameters,v=A[e];if(!v)return;const n=t.externalBlocks.getCursor(e),j=n.bytePosition,f=j+r;if(f>v.content.length)throw new aA("attempted to read beyond end of block. this file seems truncated.");return n.bytePosition=f,v.content.subarray(j,f)}}function KA(A,t,r,e){const v=!!(e.mate||void 0!==e.mateRecordNumber&&e.mateRecordNumber!==t);r.readName||(r.readName=String(r.uniqueId),e.readName=r.readName),r.mate={sequenceId:e.sequenceId,alignmentStart:e.alignmentStart,uniqueId:e.uniqueId},e.readName&&(r.mate.readName=e.readName),e.mate||void 0!==e.mateRecordNumber||(e.mate={sequenceId:r.sequenceId,alignmentStart:r.alignmentStart,uniqueId:r.uniqueId},r.readName&&(e.mate.readName=r.readName)),r.flags|=j,e.flags&s&&(r.flags|=b),r.flags&s&&(e.flags|=b),e.flags&i&&(r.flags|=o),r.flags&i&&(e.flags|=o),void 0===r.templateLength&&(v?function(A,t,r){const e=function t(r){const e=[r];if(void 0!==r.mateRecordNumber&&r.mateRecordNumber>=0){const v=A[r.mateRecordNumber];if(!v)throw new U("intra-slice mate record not found, this file seems malformed");e.push(...t(v))}return e}(r),v=e.map(A=>A.alignmentStart),n=e.map(A=>A.alignmentStart+A.readLength-1),j=Math.max(...n)-Math.min(...v)+1;j>=0&&e.forEach(A=>{if(void 0!==A.templateLength)throw new U("mate pair group has some members that have template lengths already, this file seems malformed");A.templateLength=j})}(A,0,r):function(A,t){const r=Math.min(A.alignmentStart,t.alignmentStart),e=Math.max(A.alignmentStart+A.readLength-1,t.alignmentStart+t.readLength-1)-r+1;A.templateLength=e,t.templateLength=e}(r,e)),r.mateRecordNumber=void 0}class MA{constructor(A,t,r){this.container=A,this.containerPosition=t,this.sliceSize=r,this.file=A.file}async getHeader(){const{majorVersion:A}=await this.file.getDefinition(),t=uA(A),r=await this.container.getHeader(),e=await this.file.readBlock(r._endPosition+this.containerPosition);if("MAPPED_SLICE_HEADER"===e.contentType){const A=bA(e.content,t.cramMappedSliceHeader.parser,0,r._endPosition);return{...e,parsedContent:A}}if("UNMAPPED_SLICE_HEADER"===e.contentType){const A=bA(e.content,t.cramUnmappedSliceHeader.parser,0,r._endPosition);return{...e,parsedContent:A}}throw new U(`error reading slice header block, invalid content type ${e.contentType}`)}async getBlocks(){const A=await this.getHeader();if(this.sliceSize){const t=(await this.container.getHeader())._endPosition+this.containerPosition,r=A._endPosition,e=r-t,v=this.sliceSize-e,n=await this.file.read(v,r),j=new Array(A.parsedContent.numBlocks);let f=0;for(let A=0;A<j.length;A++){const t=await this.file.readBlockFromBuffer(n,f,r+f);j[A]=t,f=t._endPosition-r}return j}let t=A._endPosition;const r=new Array(A.parsedContent.numBlocks);for(let A=0;A<r.length;A++){const e=await this.file.readBlock(t);r[A]=e,t=r[A]._endPosition}return r}async getCoreDataBlock(){return(await this.getBlocks())[0]}async _getBlocksContentIdIndex(){const A=await this.getBlocks(),t={};return A.forEach(A=>{"EXTERNAL_DATA"===A.contentType&&(t[A.contentId]=A)}),t}async getBlockByContentId(A){return(await this._getBlocksContentIdIndex())[A]}async getReferenceRegion(){const A=new TextDecoder("utf8"),t=(await this.getHeader()).parsedContent;if(!CA(t))throw new Error("slice header not mapped");if(t.refSeqId<0)return;const r=await this.container.getCompressionScheme();if(void 0===r)throw new Error("compression scheme undefined");if(t.refBaseBlockId>=0){const r=await this.getBlockByContentId(t.refBaseBlockId);if(!r)throw new U("embedded reference specified, but reference block does not exist");return{seq:A.decode(r.data),start:t.refSeqStart,end:t.refSeqStart+t.refSeqSpan-1,span:t.refSeqSpan}}if(r.referenceRequired||this.file.fetchReferenceSequenceCallback){if(!this.file.fetchReferenceSequenceCallback)throw new Error("reference sequence not embedded, and seqFetch callback not provided, cannot fetch reference sequence");const A=await this.file.fetchReferenceSequenceCallback(t.refSeqId,t.refSeqStart,t.refSeqStart+t.refSeqSpan-1);if(A.length!==t.refSeqSpan)throw new z("seqFetch callback returned a reference sequence of the wrong length");return{seq:A,start:t.refSeqStart,end:t.refSeqStart+t.refSeqSpan-1,span:t.refSeqSpan}}}getAllRecords(){return this.getRecords(()=>!0)}async _fetchRecords(A){const{majorVersion:t}=await this.file.getDefinition(),r=await this.container.getCompressionScheme();if(void 0===r)throw new Error("compression scheme undefined");const e=await this.getHeader(),v=await this._getBlocksContentIdIndex();if(t>1&&this.file.options.checkSequenceMD5&&CA(e.parsedContent)&&e.parsedContent.refSeqId>=0&&"0000000000000000"!==e.parsedContent.md5?.join("")){const A=await this.getReferenceRegion();if(A){const{seq:t,start:r,end:v}=A,n=function(A){return nA(A.toUpperCase().replaceAll(/[^\u0021-\u007e]/g,""))}(t),j=e.parsedContent.md5?.map(A=>(A<16?"0":"")+A.toString(16)).join("");if(n!==j)throw new U(`MD5 checksum reference mismatch for ref ${e.parsedContent.refSeqId} pos ${r}..${v}. recorded MD5: ${j}, calculated MD5: ${n}`)}}const n=await this.getCoreDataBlock(),j={lastAlignmentStart:CA(e.parsedContent)?e.parsedContent.refSeqStart:0,coreBlock:{bitPosition:7,bytePosition:0},externalBlocks:{map:new Map,getCursor(A){let t=this.map.get(A);return void 0===t&&(t={bitPosition:7,bytePosition:0},this.map.set(A,t)),t}}},f=new Map,s=A=>{let t=f.get(A);if(void 0===t){if(t=r.getCodecForDataSeries(A),!t)throw new U(`no codec defined for ${A} data series`);f.set(A,t)}return t.decode(this,n,v,j)},b=r.getCodecForDataSeries("QS"),i=r.getCodecForDataSeries("BA"),o=b instanceof FA,a=i instanceof FA,g=o||a?(A,t)=>"QS"===A&&o?b.getBytesSubarray(v,j,t):"BA"===A&&a?i.getBytesSubarray(v,j,t):void 0:void 0,I=new Array(e.parsedContent.numRecords);for(let f=0;f<I.length;f+=1)try{const b=SA(this,s,r,e,n,v,j,t,f,A,g);I[f]=new u({...b,uniqueId:e.contentPosition+e.parsedContent.recordCounter+f+1})}catch(A){if(A instanceof aA){const t=f,r=e.parsedContent.numRecords;throw new U(`Failed to decode all records in slice. Decoded ${t} of ${r} expected records. Buffer overrun suggests either: (1) file is truncated/corrupted, (2) compression scheme is incorrect, or (3) there's a bug in the decoder. Original error: ${A.message}`)}throw A}for(let A=0;A<I.length;A+=1){const t=I[A];if(t){const{mateRecordNumber:r}=t;void 0!==r&&r>=0&&I[r]&&KA(I,A,t,I[r])}}return I}async getRecords(A,t){const r={...l,...t},e=""+(r.decodeTags?1:0),v=`${this.container.filePosition}:${this.containerPosition}:${e}`;let n=this.file.featureCache.get(v);n||(n=this._fetchRecords(r),this.file.featureCache.set(v,n));const j=(await n).filter(A);if(j.length&&this.file.fetchReferenceSequenceCallback){const A=await this.getHeader();if(CA(A.parsedContent)&&(A.parsedContent.refSeqId>=0||-2===A.parsedContent.refSeqId)){const t=A.parsedContent.refSeqId>=0?A.parsedContent.refSeqId:void 0,r=await this.container.getCompressionScheme();if(void 0===r)throw new Error("compression scheme undefined");const e={};for(const A of j){const r=void 0!==t?t:A.sequenceId;let v=e[r];v||(v={id:r,start:A.alignmentStart,end:Number.NEGATIVE_INFINITY,seq:null},e[r]=v);const n=A.alignmentStart+(A.lengthOnRef||A.readLength)-1;n>v.end&&(v.end=n),A.alignmentStart<v.start&&(v.start=A.alignmentStart)}await Promise.all(Object.values(e).map(async A=>{-1!==A.id&&A.start<=A.end&&this.file.fetchReferenceSequenceCallback&&(A.seq=await this.file.fetchReferenceSequenceCallback(A.id,A.start,A.end))}));for(const A of j){const v=e[void 0!==t?t:A.sequenceId];if(v?.seq){const t=v.seq;A.addReferenceSequence({...v,seq:t},r)}}}}return j}}"getHeader getBlocks _getBlocksContentIdIndex".split(" ").forEach(A=>{iA(MA,A)});class RA extends GA{constructor(A,t,r){super(A,t),this.instantiateCodec=r}decode(A,t,r,e){const v=this._getLengthCodec().decode(A,t,r,e)||0,n=new Uint8Array(v);if(v>0){const j=this._getDataCodec();for(let f=0;f<v;f+=1)n[f]=j.decode(A,t,r,e)||0}return n}_getLengthCodec(){const A=this.parameters.lengthsEncoding;return this.instantiateCodec(A,"int")}_getDataCodec(){const A=this.parameters.valuesEncoding;return this.instantiateCodec(A,"byte")}}function OA(A,t,r){let{bytePosition:e,bitPosition:v}=t;if(1===r){const r=A[e]>>v&1;return v-=1,v<0&&(e+=1,v=7),t.bytePosition=e,t.bitPosition=v,r}let n=0;for(let t=0;t<r;t++)n<<=1,n|=A[e]>>v&1,v-=1,v<0&&(e+=1,v=7);return t.bytePosition=e,t.bitPosition=v,n}"_getLengthCodec _getDataCodec".split(" ").forEach(A=>{iA(RA,A)});const HA={1:FA,3:class extends GA{constructor(A,t){if(super(A,t),this.codes={},this.codeBook={},this.sortedCodes=[],this.sortedValuesByBitCode=[],this.sortedBitCodes=[],this.sortedBitLengthsByBitCode=[],this.bitCodeToValue=[],!["byte","int"].includes(this.dataType))throw new TypeError(`${this.dataType} decoding not yet implemented by HUFFMAN_INT codec`);this.buildCodeBook(),this.buildCodes(),this.buildCaches(),0===this.sortedCodes[0].bitLength&&(this._decode=this._decodeZeroLengthCode)}buildCodeBook(){let A=new Array(this.parameters.numCodes);for(let t=0;t<this.parameters.numCodes;t++)A[t]={symbol:this.parameters.symbols[t],bitLength:this.parameters.bitLengths[t]};A=A.sort((A,t)=>A.bitLength-t.bitLength||A.symbol-t.symbol),this.codeBook={},A.forEach(A=>{this.codeBook[A.bitLength]||(this.codeBook[A.bitLength]=[]),this.codeBook[A.bitLength].push(A.symbol)})}buildCodes(){this.codes={};let A=0,t=-1;Object.entries(this.codeBook).forEach(([r,e])=>{const v=Number.parseInt(r,10);e.forEach(r=>{const e={bitLength:v,value:r,bitCode:0};t+=1;const n=v-A;if(t<<=n,e.bitCode=t,A+=n,function(A){let t=A-(A>>1)&1431655765;return t=(858993459&t)+(t>>2&858993459),16843009*(t+(t>>4)&252645135)>>24}(t)>v)throw new U("Symbol out of range");this.codes[r]=e})})}buildCaches(){this.sortedCodes=Object.values(this.codes).sort((A,t)=>A.bitLength-t.bitLength||A.bitCode-t.bitCode),this.sortedValuesByBitCode=this.sortedCodes.map(A=>A.value),this.sortedBitCodes=this.sortedCodes.map(A=>A.bitCode),this.sortedBitLengthsByBitCode=this.sortedCodes.map(A=>A.bitLength);const A=Math.max(...this.sortedBitCodes);this.bitCodeToValue=new Array(A+1).fill(-1);for(let A=0;A<this.sortedBitCodes.length;A+=1)this.bitCodeToValue[this.sortedCodes[A].bitCode]=A}decode(A,t,r,e){return this._decode(A,t,e.coreBlock)}_decodeZeroLengthCode(){return this.sortedCodes[0].value}_decode(A,t,r){const e=t.content;let v=0,n=0;for(let A=0;A<this.sortedCodes.length;A+=1){const t=this.sortedCodes[A].bitLength,j=t-v;j>0&&(n<<=j,n|=OA(e,r,j)),v=t;{const r=this.bitCodeToValue[n];if(r>-1&&this.sortedBitLengthsByBitCode[r]===t)return this.sortedValuesByBitCode[r];for(let r=A;this.sortedCodes[r+1].bitLength===t&&r<this.sortedCodes.length;r+=1)A+=1}}throw new U("Huffman symbol not found.")}},4:RA,5:class extends GA{decode(A,t,r,e){const{blockContentId:v}=this.parameters,n=r[v];if(!n)throw new U(`no block found with content ID ${v}`);const j=e.externalBlocks.getCursor(v);return this._decodeByteArray(n,j)}_decodeByteArray(A,t){const r=A.content,{stopByte:e}=this.parameters,v=t.bytePosition;let n=t.bytePosition;for(;r[n]!==e&&n<r.length;){if(n===r.length)throw new aA("byteArrayStop reading beyond length of data buffer?");n+=1}return t.bytePosition=n+1,r.subarray(v,n)}},6:class extends GA{constructor(A,t){if(super(A,t),"int"!==this.dataType)throw new T(`${this.dataType} decoding not yet implemented by BETA codec`)}decode(A,t,r,e){return function(A,t,r,e){let{bytePosition:v,bitPosition:n}=t;if(8===r&&7===n){const r=A[v];return t.bytePosition=v+1,r-e}let j=0;for(let t=0;t<r;t++)j<<=1,j|=A[v]>>n&1,n-=1,n<0&&(v+=1,n=7);return t.bytePosition=v,t.bitPosition=n,j-e}(t.content,e.coreBlock,this.parameters.length,this.parameters.offset)}},7:class extends GA{constructor(A,t){if(super(A,t),"int"!==this.dataType)throw new T(`${this.dataType} decoding not yet implemented by SUBEXP codec`)}decode(A,t,r,e){return function(A,t,r,e){let{bytePosition:v,bitPosition:n}=t,j=0;for(;;){const t=A[v]>>n&1;if(n-=1,n<0&&(v+=1,n=7),0===t)break;j+=1}const f=0===j?r:j+r-1;let s=0;for(let t=0;t<f;t++)s<<=1,s|=A[v]>>n&1,n-=1,n<0&&(v+=1,n=7);return t.bytePosition=v,t.bitPosition=n,(0===j?s:1<<f|s)-e}(t.content,e.coreBlock,this.parameters.K,this.parameters.offset)}},9:class extends GA{constructor(A,t){if(super(A,t),"int"!==this.dataType)throw new T(`${this.dataType} decoding not yet implemented by GAMMA codec`)}decode(A,t,r,e){return function(A,t,r){let{bytePosition:e,bitPosition:v}=t,n=1;for(;;){const t=A[e]>>v&1;if(v-=1,v<0&&(e+=1,v=7),1===t)break;n+=1}let j=0;const f=n-1;if(f>0)for(let t=0;t<f;t++)j<<=1,j|=A[e]>>v&1,v-=1,v<0&&(e+=1,v=7);return t.bytePosition=e,t.bitPosition=v,(j|1<<n-1)-r}(t.content,e.coreBlock,this.parameters.offset)}}};function JA(A,t){const r=(e="ignore"===t?0:A.codecId,HA[e]);var e;if(!r)throw new T(`no codec implemented for codec ID ${A.codecId}`);return new r(A.parameters,t,JA)}const LA={BF:"int",CF:"int",RI:"int",RL:"int",AP:"int",RG:"int",MF:"int",NS:"int",NP:"int",TS:"int",NF:"int",TC:"byte",TN:"int",FN:"int",FC:"byte",FP:"int",BS:"byte",IN:"byteArray",SC:"byteArray",DL:"int",BA:"byte",BB:"byteArray",RS:"int",PD:"int",HC:"int",MQ:"int",RN:"byteArray",QS:"byte",QQ:"byteArray",TL:"int"};class PA{constructor(A){this.dataSeriesCodecCache={},this.tagCodecCache={},this.tagEncoding={},this.readNamesIncluded=A.preservation.RN,this.APdelta=A.preservation.AP,this.referenceRequired=!!A.preservation.RR,this.tagIdsDictionary=A.preservation.TD,this.substitutionMatrix=function(A){const t=new Array(5);for(let A=0;A<5;A+=1)t[A]=new Array(4);return t[0][A[0]>>6&3]="C",t[0][A[0]>>4&3]="G",t[0][A[0]>>2&3]="T",t[0][3&A[0]]="N",t[1][A[1]>>6&3]="A",t[1][A[1]>>4&3]="G",t[1][A[1]>>2&3]="T",t[1][3&A[1]]="N",t[2][A[2]>>6&3]="A",t[2][A[2]>>4&3]="C",t[2][A[2]>>2&3]="T",t[2][3&A[2]]="N",t[3][A[3]>>6&3]="A",t[3][A[3]>>4&3]="C",t[3][A[3]>>2&3]="G",t[3][3&A[3]]="N",t[4][A[4]>>6&3]="A",t[4][A[4]>>4&3]="C",t[4][A[4]>>2&3]="G",t[4][3&A[4]]="T",t}(A.preservation.SM),this.dataSeriesEncoding=A.dataSeriesEncoding,this.tagEncoding=A.tagEncoding}getCodecForTag(A){const t=this.tagCodecCache[A];if(t)return t;{const t=this.tagEncoding[A];if(!t)throw new Error("Error, no tag encoding");const r=JA(t,"byteArray");return this.tagCodecCache[A]=r,r}}getTagNames(A){return this.tagIdsDictionary[A]}getCodecForDataSeries(A){let t=this.dataSeriesCodecCache[A];if(void 0===t){const r=this.dataSeriesEncoding[A];if(r){const e=LA[A];if(!e)throw new U(`data series name ${A} not defined in file compression header`);t=JA(r,e),this.dataSeriesCodecCache[A]=t}}return t}toJSON(){const A={};return Object.keys(this).forEach(t=>{t.endsWith("Cache")||(A[t]=this[t])}),A}}class _A{constructor(A,t){this.file=A,this.filePosition=t}getHeader(){return this._readContainerHeader(this.filePosition)}async getCompressionHeaderBlock(){if(!(await this.getHeader()).numRecords)return null;const{majorVersion:A}=await this.file.getDefinition(),t=uA(A),r=await this.getFirstBlock();if("COMPRESSION_HEADER"!==r.contentType)throw new U(`invalid content type ${r.contentType} in compression header block`);const e=bA(r.content,t.cramCompressionHeader.parser,0,r.contentPosition);return{...r,parsedContent:e}}async getFirstBlock(){const A=await this.getHeader();return this.file.readBlock(A._endPosition)}async getCompressionScheme(){const A=await this.getCompressionHeaderBlock();if(A)return new PA(A.parsedContent)}getSlice(A,t){return new MA(this,A,t)}async _readContainerHeader(A){const{majorVersion:t}=await this.file.getDefinition(),r=uA(t),{cramContainerHeader1:e,cramContainerHeader2:v}=r,n=bA(await this.file.read(e.maxLength,A),e.parser),j=-128&(f=n.numLandmarks)?-16384&f?-2097152&f?-268435456&f?5:4:3:2:1;var f;const s=bA(await this.file.read(v.maxLength(n.numLandmarks),A+n._size-j),v.parser);return this.file.validateChecksums&&void 0!==s.crc32&&await this.file.checkCrc32(A,n._size+s._size-j-4,s.crc32,`container header beginning at position ${A}`),{...n,...s,_size:n._size+s._size-j,_endPosition:n._size+s._size-j+A}}}"getHeader getCompressionHeaderBlock getCompressionScheme".split(" ").forEach(A=>{iA(_A,A)});class $A{constructor(A){this.exports=A.exports,this.memory=this.exports.memory,this.ptr=this.exports.create_context(),this._refresh(),this.bufSize=this.mem32[0],this.inStart=this.mem32[1]-this.ptr,this.outStart=this.mem32[4]-this.ptr}supplyInput(A){this._refresh(),this.mem8.subarray(this.inStart,this.inStart+this.bufSize).set(A,0),this.exports.supply_input(this.ptr,A.byteLength)}getNextOutput(){const A=this.exports.get_next_output(this.ptr);if(this._refresh(),0!==A&&1!==A)throw new Error(`get_next_output failed with error code ${A}`);return{outChunk:this.mem8.slice(this.outStart,this.outStart+this.mem32[5]),finished:1===A}}dispose(){this.exports.destroy_context(this.ptr),this.exports=null}_refresh(){const A=this.memory.buffer;A!==this.mem8?.buffer&&(this.mem8=new Uint8Array(A,this.ptr),this.mem32=new Uint32Array(A,this.ptr))}}let YA,TA;const UA=new Uint8Array(0);class zA{constructor(A){if(this.file=vA(A.url,A.path,A.filehandle),this.validateChecksums=!0,this.fetchReferenceSequenceCallback=A.seqFetch,this.options={checkSequenceMD5:A.checkSequenceMD5,cacheSize:A.cacheSize??2e4},this.featureCache=new P({maxSize:this.options.cacheSize}),function(){const A=new Uint32Array([287454020]),t=new Uint8Array(A.buffer);return 68===t[0]?0:17===t[0]?1:2}()>0)throw new Error("Detected big-endian machine, may be unable to run")}read(A,t){return this.file.read(A,t)}async getDefinition(){const{maxLength:A,parser:t}=gA(),r=t(await this.file.read(A,0)).value;if("CRAM"!==r.magic)throw new Error("Not a CRAM file, does not match magic string");if(2!==r.majorVersion&&3!==r.majorVersion)throw new T(`CRAM version ${r.majorVersion} not supported`);return r}async getSamHeader(){const A=await this.getContainerById(0);if(!A)throw new U("file contains no containers");const t=(await A.getFirstBlock()).content,r=new DataView(t.buffer).getInt32(0,!0),e=new TextDecoder("utf8").decode(t.subarray(4,4+r));return this.header=e,function(A){const t=A.split(/\r?\n/),r=[];for(const A of t){const[t,...e]=A.split(/\t/);t&&r.push({tag:t.slice(1),data:e.map(A=>{const t=A.indexOf(":");return-1!==t?{tag:A.slice(0,t),value:A.slice(t+1)}:{tag:A,value:""}})})}return r}(e)}async getHeaderText(){return await this.getSamHeader(),this.header}async getContainerById(A){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=uA(A)}let t,r=this._sectionParsers.cramFileDefinition.maxLength;for(let e=0;e<=A;e++){t=this.getContainerAtPosition(r);const A=await t.getHeader();if(0===e){r=A._endPosition;for(let t=0;t<A.numBlocks;t++)r=(await this.readBlock(r))._endPosition}else r+=A._size+A.length}return t}async checkCrc32(A,t,r,e){const v=await this.file.read(t,A),n=$(v)>>>0;if(n!==r)throw new U(`crc mismatch in ${e}: recorded CRC32 = ${r}, but calculated CRC32 = ${n}`)}async containerCount(){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=uA(A)}let A=0,t=this._sectionParsers.cramFileDefinition.maxLength;try{for(;;){const r=await this.getContainerAtPosition(t).getHeader();if(0===A){t=r._endPosition;for(let A=0;A<r.numBlocks;A++)t=(await this.readBlock(t))._endPosition}else t+=r._size+r.length;A+=1}}catch(t){A--}return A}getContainerAtPosition(A){return new _A(this,A)}async readBlockHeader(A){if(!this._sectionParsers){const{majorVersion:A}=await this.getDefinition();this._sectionParsers=uA(A)}const{cramBlockHeader:t}=this._sectionParsers;return bA(await this.file.read(t.maxLength,A),t.parser,0,A)}async _parseSection(A,t,r=A.maxLength,e){const v=bA(e??await this.file.read(r,t),A.parser,0,t);if(v._size!==r)throw new U(`section read error: requested size ${r} does not equal parsed size ${v._size}`);return v}async _uncompressPre(A,t,r){if("gzip"===A)return await oA(t);if("bzip2"===A)return await async function(A,t){if(0===A.length)return new Uint8Array(0);const r=await Z(),e=AA(r,A),v=r._malloc(4);try{const n=r._bz2_uncompress(e,A.length,t,v);if(0===n)throw new Error("bz2_uncompress failed");const j=r.getValue(v,"i32"),f=tA(r,n,j);return r._free(n),f}finally{r._free(e),r._free(v)}}(t,r);if("lzma"===A)return async function(A){TA||await(YA||(YA=async function(){const 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AjYCqAEgACAMaiELIAIhDCALQbABai0AAA0ODAALCyAFQgA3AwAgAEEANgKoASAAQQM2AgAgBUEIakIANwMACyAAIAEoAgQ2AhAgACABKAIQNgIUIAAoArAJIAEQmYCAgAAhDCAAIAApA0ggASgCBCAAKAIQa618Ig43A0ggACAAKQNQIAEoAhAgACgCFCICayILrXwiDzcDUCAOIAApAzBWDQ0gDyAAKQM4Vg0NAkACQAJAAkAgACgCIEF/ag4EAAMDAQMLIAEoAgwgAmogCyAAKAIYEI2AgIAArSEODAELIAEoAgwgAmogCyAAKQMYEI+AgIAAIQ4LIAAgDjcDGAsgDEEBRw0OAkAgACkDMCIOQn9RDQAgDiAFKQMAUg0OCwJAIAApAzgiDkJ/UQ0AQQchDCAOIAApA1BSDQ8LIAAgACkDSCAANQJAfCAAKQNgfCIPNwNgQgQhDgJAAkACQCAAKAIgQX9qDgQBAgIAAgtCCCEOCyAEIA4gD3w3AwALIAAgACkDaCAAKQNQfDcDaCAAIARBGCAAKAJwEI2AgIAANgJwIABBBDYCACAAIAApA1hCAXw3A1gLAkAgBSkDACIOQgODUA0AIA5CAXwhDiABKAIEIQwgASgCCCELA0AgCyAMRg0NIAEgDEEBaiICNgIEIAEoAgAgDGotAAANDiAFIA43AwAgDkIDgyEPIA5CAXwhDiACIQwgD0IAUg0ACwsgAEEFNgIAC0EBIQIgACgCIEF/ag4EBgcHBQcLIAAgARCSgICAACIMQQFHDQsgAEEHNgIAC0EAIAAoAhBrIQUgAEGAAWopAwAhDiABKAIEIQwCQANAIA4gBSAMaq18QgODUA0BAkAgDCABKAIIRw0AIAAgARCTgICAAAwLCyABIAxBAWoiAjYCBCABKAIAIAxqIQsgAiEMIAstAAANCwwACwsgACABEJOAgIAAQQchDCAEIABBkAFqQRgQhICAgAANCiAAQQg2AgALIAAgAUEgEJSAgIAAIgxBAUcNCSAAQQk2AgBBDCELIABBDDYCrAEMAQsgACgCrAEhCwsgByAAKAKoASIMaiABKAIAIAEoAgQiAmogASgCCCACayICIAsgDGsiDCACIAxJGyICEIeAgIAAGiABIAEoAgQgAmo2AgRBACEMIABBACAAKAKoASACaiICIAIgACgCrAEiC0YbNgKoASACIAtHDQcgABCVgICAACEMDAcLQQEhAiAAIAFBwAAQlICAgAAiDEEBRw0GDAELQQEhAiAAIAFBIBCUgICAACIMQQFHDQULIAAgAjYCAAwACwtBBiEMDAILQQAhDAwBC0EHIQwLAkACQCAAKAIkDQACQAJAIAwOAgADAQtBB0EIIAEoAgQgASgCCEYbIQwLIAEgCTYCECABIAM2AgQgDA8LAkAgDA0AIAMgASgCBEcNACAJIAEoAhBHDQAgAC0AKCEBIABBAToAKCABQQN0DwsgAEEAOgAoCyAMC6YBAQN/AkAgACgCBCIEDQAgAEIANwMICyACKAIAIgUgAyAFIANLGyEGA0ACQCAGIAVHDQBBAA8LIAEgBWotAAAhAyACIAVBAWoiBTYCACAAIANB/wBxrSAErYYgACkDCIQ3AwgCQAJAIAPAIgNBAEgNAAJAIAMNAEEHIQMgBA0CCyAAQQA2AgRBAQ8LQQchAyAAIARBB2oiBDYCBCAEQT9HDQELCyADC6ECAgN/AX4gAEGQAWohAiABQQRqIQMDQAJAIAAgASgCACADIAEoAggQkYCAgAAiBEEBRg0AIABBgAFqIgMgAykDACABKAIEIAAoAhAiA2siAq18NwMAIAAgAyABKAIAaiACIAAoAhgQjYCAgACtNwMYIAQPCwJAAkACQAJAAkAgACgCeA4DAAIBAwsgACAAKQMIIgU3A4gBAkAgBSAAKQNYUQ0AQQcPCyAAQQE2AngMAwsgACAAKQOYASAAKQMIfDcDmAEgACACQRggACgCoAEQjYCAgAA2AqABIABBATYCeCAAIAApA4gBQn98IgU3A4gBDAILIABBAjYCeCAAIAApA5ABIAApAwh8NwOQAQsgACkDiAEhBQsgBUIAUg0AC0EBC0ABAn8gAEGAAWoiAiACKQMAIAEoAgQgACgCECICayIDrXw3AwAgACACIAEoAgBqIAMgACgCGBCNgICAAK03AxgLfAEEfyABKAIEIQMgASgCCCEEA0ACQCAEIANHDQBBAA8LIAEgA0EBaiIFNgIEAkAgASgCACADai0AACAAKQMYIAAoAgQiA62Ip0H/AXFGDQBBBw8LIAAgA0EIaiIGNgIEIAUhAyAGIAJJDQALIABBADYCBCAAQgA3AxhBAQtvAQF/QQchAQJAIABBugFqLwAAQdm0AUcNACAAQbQBakEGQQAQjYCAgAAgAEGwAWooAABHDQAgAEGAAWopAwBCAoggADUAtAFSDQAgAEG4AWotAAANAEEBQQcgACgCICAAQbkBai0AAEYbIQELIAELwAIBA38CQAJAAkAgACgCJA0AIABBADoAKCAAQQA2AgBBASECDAELAkAgACgCAEEKRw0AQQAhAwwCC0ECIQMMAQtBASEDCwJAAkADQAJAAkACQAJAIAMOAwABAwMLIAEoAgQiAyABKAIIIgRGDQQgASgCACEFAkADQCAFIANqLQAADQEgASADQQFqIgM2AgQgACAAKAIEQQFqQQNxNgIEIAQgA0YNBgwACwsCQCAAKAIERQ0AQQcPCyAAKAIkRQ0BIABBADoAKCAAQQA2AgBBASEDDAMLIABCADcDGCAAQQA2AgQgAEHIAGpBAEHkABCGgICAABogAEGsAWpBDDYCAAtBAiEDDAELIAAgARCQgICAACIDQQFHDQIgAEEKNgIAQQAhAwwACwsCQCACDQBBAA8LQQdBASAAKAIEGyEDCyADC3UBAX8CQEG4CRCAgICAACICRQ0AIAIgADYCJCACIAAgARCbgICAACIANgKwCQJAIABFDQAgAkEAOgAoIAJCADcDACACQgA3AxggAkHIAGpBAEHkABCGgICAABogAkGsAWpBDDYCACACDwsgAhCCgICAAAtBAAseAAJAIABFDQAgACgCsAkQnYCAgAAgABCCgICAAAsL3RABCn8gAEHo3QFqIQIgAEHUAGohAyAAQRxqIgRBCGohBQJAAkADQCAAKAJAIQYCQAJAAkACQAJAAkACQAJAAkACQAJAAkACQAJAAkAgASgCBCIHIAEoAghJDQAgBkEHRg0BDBELIAYOCQECAwQFBgcACQ4LIAAoAkwhBgwHC0EBIQYgASAHQQFqNgIEIAEoAgAgB2otAAAiB0UNCAJAAkAgB0HfAUsNACAHQQFHDQELIABBgAI7AVACQCAAKAI8DQAgACABKAIMIAEoAhAiBmo2AhggACABKAIUIAZrNgIsCyAEQgA3AgAgBUIANwIADAoLIAAtAFBFDQkMDQsgASAHQQFqNgIEIAEoAgAgB2otAAAhByAAQQI2AkAgACAHQQh0IAAoAkhqNgJIDAsLIAEgB0EBajYCBCABKAIAIAdqLQAAIQcgAEEDNgJAIAAgByAAKAJIakEBajYCSAwKCyABIAdBAWo2AgQgASgCACAHai0AACEHIABBBDYCQCAAIAdBCHQ2AkwMCQsgASAHQQFqNgIEIAEoAgAgB2otAAAhByAAIAAoAkQ2AkAgACAHIAAoAkxqQQFqNgJMDAgLIAEgB0EBajYCBEEHIQYgASgCACAHai0AACIHQeABSw0DQQAhCAJAAkAgB0EtTw0AQQAhCQwBCyAHQVNqIgcgB0H/AXFBLW4iCUEtbGshByAJQQFqIQkLIABBfyAJdEF/czYCdAJAIAdB/wFxQQlJDQAgB0F3aiIHIAdB/wFxQQluIghBCWxrIQcgCEEBaiEICyAAIAg2AnAgACAHQf8BcSIHNgJsIAggB2pBBEsNAyADQgA3AgAgA0EIakIANwIAIANBEGpBADYCACAAQX8gCHRBf3M2AnBB+AAhBwNAIAAgB2pBgAg7AQAgB0ECaiIHQeTdAUcNAAsgAEEGNgJAIABBBTYCCCAAQv////8PNwIACyAAKAJMIgpBBUkNBwJAIAAoAggiB0UNACAHQX9qIQYgASgCBCEHIAEoAgghCQNAIAkgB0YNCiABIAdBAWoiCDYCBCABKAIAIAdqLQAAIQcgACAGNgIIIAAgByAAKAIEQQh0cjYCBCAIIQcgBkF/aiIGQX9HDQALCyAAQQc2AkAgACAKQXtqIgY2AkwLIAAgACgCICIHIAEoAhQgASgCEGsiCCAAKAJIIgkgCCAJSRsiCGogACgCLCIJIAkgB2sgCEsbNgIoIAEoAggiCiABKAIEIghrIQcCQAJAAkAgACgC5N0BIgkNACAGDQFBACEGCyACIAlqIAEoAgAgCGpBKiAJayIIIAYgCWsiBiAIIAZJGyIGIAcgBiAHSRsiBxCHgICAABoCQAJAIAAoAuTdASIIIAdqIgYgACgCTEcNACACIAhqIAdqQQBBPyAGaxCGgICAABogACgC5N0BIAdqIQYMAQsCQCAGQRRLDQAgACAGNgLk3QEgASABKAIEIAdqNgIEDAMLIAZBa2ohBgsgAEEANgIQIAAgAjYCDCAAIAY2AhRBByEGIAAQmoCAgABFDQMgACgCECIIIAAoAuTdASIJIAdqSw0DIAAgACgCTCAIayIGNgJMAkAgCCAJTw0AIAAgCSAIayIHNgLk3QEgAiACIAhqIAcQhYCAgAAaDAILIABBADYC5N0BIAEgASgCBCAIIAlraiIINgIEIAEoAggiCiAIayEHCwJAIAdBFUkNACAAIAg2AhAgACABKAIANgIMIAAgCkFraiAIIAZqIAcgBkEVakkbNgIUQQchBiAAEJqAgIAARQ0DIAAoAkwiByAAKAIQIgggASgCBGsiCUkNAyABIAg2AgQgACAHIAlrIgY2AkwgASgCCCAIayIHQRRLDQELIAIgASgCACAIaiAHIAYgByAGSRsiBxCHgICAABogACAHNgLk3QEgASABKAIEIAdqNgIECyAAKAIgIgYgACgCHCIIayEHAkAgACgCPEUNAAJAIAYgACgCLEcNACAAQQA2AiALIAEoAgwgASgCEGogACgCGCAIaiAHEIeAgIAAGiAAKAIgIQYLIAAgBjYCHCABIAEoAhAgB2oiCDYCECAAIAAoAkgiBiAHazYCSAJAIAYgB0cNAEEHIQYgACgCTA0CIAAoAmgNAiAAKAIEDQIgAEEANgJADAQLQQAhBiAIIAEoAhRGDQEgASgCBCABKAIIRw0FIAAoAuTdASAAKAJMTw0FDAELAkADQCAAKAJMIghFDQFBACEGIAEoAggiCSAHTQ0CIAEoAhQiCiABKAIQIgtNDQIgACAIIAkgB2siBiAKIAtrIgkgBiAJSRsiBiAAKAIsIAAoAiAiCWsiCiAGIApJGyIGIAggBiAISRsiBms2AkwgCSAAKAIYaiABKAIAIAdqIAYQhYCAgAAaIAAgACgCICAGaiIHNgIgAkAgACgCJCAHTw0AIAAgBzYCJAsCQCAAKAI8RQ0AAkAgByAAKAIsRw0AIABBADYCIAsgASgCDCABKAIQaiABKAIAIAEoAgRqIAYQhYCAgAAaIAAoAiAhBwsgACAHNgIcIAEgASgCECAGajYCECABIAEoAgQgBmoiBzYCBAwACwsgAEEANgJADAQLIAYPCyAHwEF/Sg0BIABBATYCQCAAIAdBEHRBgID8AHE2AkgCQCAHQcABSQ0AIABBBTYCRCAAQQA6AFEMAwsgAC0AUQ0DIABBBjYCRCAHQaABSQ0CIANCADcCACADQRBqQQA2AgAgA0EIakIANwIAQfgAIQcDQCAAIAdqQYAIOwEAIAdBAmoiB0Hk3QFHDQALCyAAQQU2AgggAEL/////DzcCAAwBCyAHQQJLDQEgAEKDgICAgAE3AkAMAAsLQQcPC0EAC5wYARR/IABBGGohAQJAIABBIGooAgAiAiAAQShqKAIAIgNPDQAgAEHoAGoiBCgCAEUNACABIAQgACgCVBCegICAABogACgCKCEDIAAoAiAhAgsCQCACIANPDQAgAEHYC2ohBSAAQbwNaiEGIABB3A1qIQcgAEHoAGohCCAAQeAVaiEJIABB1ABqIQoDQCAAKAIQIgsgACgCFEsNASAAIAAoAmQiDEEFdGogACgCdCACcSINQQF0aiIOQfgAaiEPAkACQCAAKAIAIgNBgICACEkNACAAKAIEIRAMAQsgACADQQh0IgM2AgAgACALQQFqIgQ2AhAgACAAKAIEQQh0IAAoAgwgC2otAAByIhA2AgQgBCELCwJAAkAgECADQQt2IA8vAQAiEWwiBE8NACAAIAQ2AgAgDyARQYAQIBFrQQV2ajsBACACQX9qIQMCQCACDQAgACgCLCADaiEDCwJAAkAgACgCJCIRDQBBACEDDAELIAEoAgAgA2otAAAhAwsgACAAKAJwIAJxIAAoAmwiD3QgA0EIIA9rdmpBgAxsakHkHWohDgJAAkAgDEEGSw0AQQEhAwNAIA4gA0EBdCIDaiEQAkACQCAAKAIAIgRBgICACEkNACAAKAIEIQwMAQsgACAEQQh0IgQ2AgAgACAAKAIQIg9BAWo2AhAgACAAKAIEQQh0IA8gACgCDGotAAByIgw2AgQLAkACQCAMIARBC3YgEC8BACIRbCIPSQ0AIAAgDCAPazYCBCAEIA9rIQ8gA0EBciEDIBEgEUEFdmshBAwBCyARQYAQIBFrQQV2aiEECyAAIA82AgAgECAEOwEAIANBgAJJDQALIAAoAiAhAgwBCyACIAAoAlQiD0F/c2ohAwJAIAIgD0sNACAAKAIsIANqIQMLAkACQCARDQBBACESDAELIAEoAgAgA2otAAAhEgtBASEDQYACIQ8DQCAOIBJBAXQiEiAPcSITIA9qIANqQQF0aiERAkACQCAEQf///wdNDQAgBCENDAELIAAgBEEIdCINNgIAIAAgC0EBaiIENgIQIAAgEEEIdCAAKAIMIAtqLQAAciIQNgIEIAQhCwsCQAJAIBAgDUELdiARLwEAIgxsIgRPIhQNACAMQYAQIAxrQQV2aiEMDAELIAAgECAEayIQNgIEIA0gBGshBCAMIAxBBXZrIQxBACEPCyAAIAQ2AgAgESAMOwEAIA8gE3MhDyADQQF0IBRyIgNBgAJJDQALCyAAIAJBAWo2AiAgACgCGCACaiADOgAAAkAgACgCJCAAKAIgIgJPDQAgACACNgIkC0EAIQMCQCAAKAJkIgRBBEkNAAJAIARBCUsNACAEQX1qIQMMAQsgBEF6aiEDCyAAIAM2AmQMAQsgACADIARrIgM2AgAgACAQIARrIgQ2AgQgDyARIBFBBXZrOwEAIAAgDEEBdGoiEkH4A2ohDwJAAkAgA0H///8HTQ0AIAshEwwBCyAAIANBCHQiAzYCACAAIAtBAWoiEzYCECAAIARBCHQgACgCDCALai0AAHIiBDYCBAsCQAJAIAQgA0ELdiAPLwEAIhBsIhFJDQAgACADIBFrIgw2AgAgACAEIBFrIgM2AgQgDyAQIBBBBXZrOwEAIBJBkARqIQ8CQAJAIAxB////B00NACATIREMAQsgACAMQQh0Igw2AgAgACATQQFqIhE2AhAgACADQQh0IAAoAgwgE2otAAByIgM2AgQLAkACQCADIAxBC3YgDy8BACIQbCIETw0AIAAgBDYCACAPIBBBgBAgEGtBBXZqOwEAIA5B2ARqIQ8CQCAEQf///wdLDQAgACAEQQh0IgQ2AgAgACARQQFqNgIQIAAgA0EIdCAAKAIMIBFqLQAAciIDNgIECwJAIAMgBEELdiAPLwEAIhBsIhFJDQAgACAEIBFrNgIAIAAgAyARazYCBCAPIBAgEEEFdms7AQAMAgsgACARNgIAIA8gEEGAECAQa0EFdmo7AQAgAEEBNgJoIABBCUELIAAoAmRBB0kbNgJkDAMLIAAgDCAEayIMNgIAIAAgAyAEayIDNgIEIA8gECAQQQV2azsBACASQagEaiEEAkACQCAMQf///wdNDQAgESEODAELIAAgDEEIdCIMNgIAIAAgEUEBaiIONgIQIAAgA0EIdCAAKAIMIBFqLQAAciIDNgIECwJAAkAgAyAMQQt2IAQvAQAiD2wiEE8NACAAIBA2AgAgBCAPQYAQIA9rQQV2ajsBACAAKAJYIQMMAQsgACAMIBBrIhE2AgAgACADIBBrIgM2AgQgBCAPIA9BBXZrOwEAIBJBwARqIQ8CQCARQf///wdLDQAgACARQQh0IhE2AgAgACAOQQFqNgIQIAAgA0EIdCAAKAIMIA5qLQAAciIDNgIECwJAAkAgAyARQQt2IA8vAQAiEGwiBE8NACAQQYAQIBBrQQV2aiEQIAAoAlwhAwwBCyAAIAMgBGs2AgQgACgCYCEDIAAgACgCXDYCYCARIARrIQQgECAQQQV2ayEQCyAAIAQ2AgAgDyAQOwEAIAAgACgCWDYCXAsgACAAKAJUNgJYIAAgAzYCVAsgAEEIQQsgACgCZEEHSRs2AmQgACAJIA0Qn4CAgAAMAQsgACARNgIAIA8gEEGAECAQa0EFdmo7AQAgACAAKAJcNgJgIAAgACkCVDcCWCAAQQdBCiAAKAJkQQdJGzYCZCAAIAcgDRCfgICAACAKIAAoAmgiA0F+akEDIANBBkkbQQd0akGEB2ohDUEBIQMDQCANIANBAXQiA2ohEAJAAkAgACgCACIEQYCAgAhJDQAgACgCBCEMDAELIAAgBEEIdCIENgIAIAAgACgCECIPQQFqNgIQIAAgACgCBEEIdCAPIAAoAgxqLQAAciIMNgIECwJAAkAgDCAEQQt2IBAvAQAiEWwiD0kNACAAIAwgD2s2AgQgBCAPayEPIANBAXIhAyARIBFBBXZrIQQMAQsgEUGAECARa0EFdmohBAsgACAPNgIAIBAgBDsBACADQcAASQ0ACwJAIANBQGoiBEEDSw0AIAAgBDYCVAwBCyAAIANBAXFBAnIiDzYCVCAEQQF2IRACQCAEQQ1LDQAgACAPIBBBf2oiDnQiBDYCVEEBIQ8gBSAEQQF0akHAACADa0EBdGpBfmohEkEAIQwDQCASIA9BAXQiD2ohEAJAAkAgACgCACIDQYCAgAhJDQAgACgCBCENDAELIAAgA0EIdCIDNgIAIAAgACgCECIEQQFqNgIQIAAgACgCBEEIdCAEIAAoAgxqLQAAciINNgIECwJAAkAgDSADQQt2IBAvAQAiEWwiBEkNACAAIA0gBGs2AgQgACAAKAJUQQEgDHRqNgJUIAMgBGshBCAPQQFyIQ8gESARQQV2ayEDDAELIBFBgBAgEWtBBXZqIQMLIAAgBDYCACAQIAM7AQAgDiAMQQFqIgxHDQAMAgsLIBBBe2ohECAAKAIEIQQgACgCACEDA0ACQCADQf///wdLDQAgACADQQh0IgM2AgAgACAAKAIQIhFBAWo2AhAgBEEIdCARIAAoAgxqLQAAciEECyAAIANBAXYiAzYCACAAIAQgA2siBEEfdSIRIA9BAXRqQQFqIg82AlQgACARIANxIARqIgQ2AgQgEEF/aiIQDQALIAAgD0EEdDYCVEEAIQxBASEPA0AgBiAPQQF0Ig9qIRACQAJAIAAoAgAiA0GAgIAISQ0AIAAoAgQhDQwBCyAAIANBCHQiAzYCACAAIAAoAhAiBEEBajYCECAAIAAoAgRBCHQgBCAAKAIMai0AAHIiDTYCBAsCQAJAIA0gA0ELdiAQLwEAIhFsIgRJDQAgACANIARrNgIEIAAgACgCVEEBIAx0ajYCVCADIARrIQQgD0EBciEPIBEgEUEFdmshAwwBCyARQYAQIBFrQQV2aiEDCyAAIAQ2AgAgECADOwEAIAxBAWoiDEEERw0ACwsCQCABIAggACgCVBCegICAAA0AQQAPCyAA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Uint8Array(r);for(let A=0;A<r;A++)e[A]=t.charCodeAt(A);const v=await WebAssembly.instantiate(e.buffer,{});TA=v.instance}()));const t=new $A(TA),r=[];let e=0,v=!1;try{for(;;){if(t.mem32[2]===t.mem32[3])if(e<A.length){const r=Math.min(t.bufSize,A.length-e);t.supplyInput(A.subarray(e,e+r)),e+=r}else{if(v)throw new Error("XZ decompression error: unexpected end of input");t.supplyInput(UA),v=!0}const n=t.getNextOutput();if(n.outChunk.length>0&&r.push(n.outChunk),t.mem32[5]=0,n.finished)break}if(1===r.length)return r[0];const n=r.reduce((A,t)=>A+t.length,0),j=new Uint8Array(n);let f=0;for(const A of r)j.set(A,f),f+=A.length;return j}finally{t.dispose()}}(t);if("rans"===A)return await async function(A){if(0===A.length)return new Uint8Array(0);const t=await Z(),r=AA(t,A),e=t._malloc(4);try{const v=t._rans_uncompress(r,A.length,e);if(0===v)throw new Error("rans_uncompress failed");const n=t.getValue(e,"i32"),j=tA(t,v,n);return t._free(v),j}finally{t._free(r),t._free(e)}}(t);if("rans4x16"===A)return await async function(A){const t=await Z(),r=AA(t,A),e=t._malloc(4);try{const v=t._rans_uncompress_4x16(r,A.length,e);if(0===v)throw new Error("rans_uncompress_4x16 failed");const n=t.getValue(e,"i32"),j=tA(t,v,n);return t._free(v),j}finally{t._free(r),t._free(e)}}(t);if("arith"===A)return await async function(A){const t=await Z(),r=AA(t,A),e=t._malloc(4);try{const v=t._arith_uncompress(r,A.length,e);if(0===v)throw new Error("arith_uncompress failed");const n=t.getValue(e,"i32"),j=tA(t,v,n);return t._free(v),j}finally{t._free(r),t._free(e)}}(t);if("fqzcomp"===A)return await async function(A){const t=await Z(),r=AA(t,A),e=t._malloc(4),v=t._malloc(4);try{const n=t._fqz_decompress(r,A.length,e,v);if(0===n)throw new Error("fqz_decompress failed");const j=t.getValue(e,"i32"),f=tA(t,n,j);return t._free(n),f}finally{t._free(r),t._free(e),t._free(v)}}(t);if("tok3"===A)return await async function(A){const t=await Z(),r=AA(t,A),e=t._malloc(4);try{const v=t._tok3_decode_names(r,A.length,e);if(0===v)throw new Error("tok3_decode_names failed");const n=t.getValue(e,"i32"),j=tA(t,v,n);return t._free(v),j}finally{t._free(r),t._free(e)}}(t);throw new T(`${A} decompression not yet implemented`)}async _uncompress(A,t,r){const e=await this._uncompressPre(A,t,r);if(e.length!==r){const A=new Uint8Array(r);return A.set(e,0),A}return e}async readBlock(A){const{majorVersion:t}=await this.getDefinition();this._sectionParsers||(this._sectionParsers=uA(t));const r=this._sectionParsers,e=await this.readBlockHeader(A),v=e._endPosition,n=await this.file.read(e.compressedSize,v),j="raw"!==e.compressionMethod?await this._uncompress(e.compressionMethod,n,e.uncompressedSize):n,f={...e,_endPosition:v,contentPosition:v,content:j};if(t>=3){const t=await this._parseSection(r.cramBlockCrc32,v+e.compressedSize);f.crc32=t.crc32,this.validateChecksums&&await this.checkCrc32(A,e._size+e.compressedSize,t.crc32,"block data"),f._endPosition=t._endPosition,f._size=f.compressedSize+r.cramBlockCrc32.maxLength}else f._endPosition=v+f.compressedSize,f._size=f.compressedSize;return f}async readBlockFromBuffer(A,t,r){const{majorVersion:e}=await this.getDefinition();this._sectionParsers||(this._sectionParsers=uA(e));const v=this._sectionParsers,{cramBlockHeader:n}=v,j=bA(A.subarray(t,t+n.maxLength),n.parser,0,r),f=j._endPosition,s=t+j._size,b=A.subarray(s,s+j.compressedSize),i="raw"!==j.compressionMethod?await this._uncompress(j.compressionMethod,b,j.uncompressedSize):b,o={...j,_endPosition:f,contentPosition:f,content:i};if(e>=3){const r=s+j.compressedSize,e=bA(A.subarray(r,r+v.cramBlockCrc32.maxLength),v.cramBlockCrc32.parser,0,f+j.compressedSize);if(o.crc32=e.crc32,this.validateChecksums){const r=A.subarray(t,t+j._size+j.compressedSize),v=$(r)>>>0;if(v!==e.crc32)throw new U(`crc mismatch in block data: recorded CRC32 = ${e.crc32}, but calculated CRC32 = ${v}`)}o._endPosition=e._endPosition,o._size=o.compressedSize+v.cramBlockCrc32.maxLength}else o._endPosition=f+o.compressedSize,o._size=o.compressedSize;return o}}function VA(A,t){const[r,e,v,n,j,f]=t,s=r;A[s]||(A[s]=[]),A[s].push({start:e,span:v,containerStart:n,sliceStart:j,sliceBytes:f})}"getDefinition getSectionParsers getSamHeader".split(" ").forEach(A=>{iA(zA,A)});class XA{constructor(A){this.filehandle=vA(A.url,A.path,A.filehandle)}async parseIndex(){const A={},t=await async function(A){return 31===A[0]&&139===A[1]?oA(A):A}(await this.filehandle.readFile()),r=new DataView(t.buffer);if(t.length>4&&21578050===r.getUint32(0,!0))throw new U("invalid .crai index file. note: file appears to be a .bai index. this is technically legal but please open a github issue if you need support");let e=[],v="";for(const r of t)if(r>=48&&r<=57||!v&&45===r)v+=String.fromCharCode(r);else if(9===r)e.push(Number.parseInt(v,10)),v="";else if(10===r)e.push(Number.parseInt(v,10)),v="",VA(A,e),e=[];else if(13!==r&&32!==r)throw new U("invalid .crai index file");return v&&e.push(Number.parseInt(v,10)),6===e.length&&VA(A,e),Object.entries(A).forEach(([t,r])=>{const e=r;A[t]=e.sort((A,t)=>A.start-t.start||A.span-t.span)}),A}getIndex(){return this.parseIndexP||(this.parseIndexP=this.parseIndex().catch(A=>{throw this.parseIndexP=void 0,A})),this.parseIndexP}async hasDataForReferenceSequence(A){return!!(await this.getIndex())[A]}async getEntriesForRange(A,t,r){const e=(await this.getIndex())[A];if(!e)return[];const v=A=>{const e=A.start,v=A.start+A.span;return e>r?-1:v<=t?1:0},n=[];for(const A of e)0===v(A)&&n.push(A);return n}}class WA{constructor(A){if(this.cram=A.cram??new zA({url:A.cramUrl,path:A.cramPath,filehandle:A.cramFilehandle,seqFetch:A.seqFetch,checkSequenceMD5:A.checkSequenceMD5,cacheSize:A.cacheSize}),!(this.cram instanceof zA))throw new Error("invalid arguments: no cramfile");this.index=A.index}async getRecordsForRange(A,t,r,e={}){const v=e.viewAsPairs||!1,n=e.pairAcrossChr||!1,j=e.maxInsertSize||2e5,f={decodeTags:e.decodeTags};if("string"==typeof A)throw new T("string sequence names not yet supported");const s=A,b=await this.index.getEntriesForRange(s,t,r),i=await Promise.all(b.map(e=>this.getRecordsInSlice(e,e=>e.sequenceId===A&&(void 0===e.lengthOnRef?e.alignmentStart>=t&&e.alignmentStart<=r:e.alignmentStart<=r&&e.alignmentStart+e.lengthOnRef-1>t),f)));let o=Array.prototype.concat(...i);if(v){const A={},t={};for(const r of o){const e=r.readName;if(void 0===e)throw new Error("readName undefined");const v=r.uniqueId;A[e]||(A[e]=0),A[e]+=1,t[v]=1}const r={};Object.entries(A).forEach(([A,t])=>{1===t&&(r[A]=!0)});const e=[];for(const A of o){const t=A.readName;if(void 0===t)throw new Error("readName undefined");if(r[t]&&A.mate&&(A.mate.sequenceId===s||n)&&Math.abs(A.alignmentStart-A.mate.alignmentStart)<j){const t=this.index.getEntriesForRange(A.mate.sequenceId,A.mate.alignmentStart,A.mate.alignmentStart+1);e.push(t)}}const v=await Promise.all(e);let f=[];for(const A of v)f.push(...A);f=f.sort((A,t)=>A.toString().localeCompare(t.toString())).filter((A,t,r)=>!t||A.toString()!==r[t-1].toString());const b=[],i=[];for(const A of f){let e=this.cram.featureCache.get(A.toString());e||(e=this.getRecordsInSlice(A,()=>!0),this.cram.featureCache.set(A.toString(),e)),b.push(e);const v=e.then(A=>{const e=[];for(const v of A){if(void 0===v.readName)throw new Error("readName undefined");r[v.readName]&&!t[v.uniqueId]&&e.push(v)}return e});i.push(v)}const a=await Promise.all(i);if(a.length){const A=a.reduce((A,t)=>A.concat(t));o=o.concat(A)}}return o}getRecordsInSlice({containerStart:A,sliceStart:t,sliceBytes:r},e,v){return this.cram.getContainerAtPosition(A).getSlice(t,r).getRecords(e,v)}hasDataForReferenceSequence(A){return this.index.hasDataForReferenceSequence(A)}}})(),window.gmodCRAM=e})();