@glycanage/web-components 1.42.0 → 1.43.0

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
@@ -1,2 +1,2 @@
1
- import{c as K,S as Q,i as U,f as R,s as W,a as _,e as g,b as L,d as P,g as G,t as Z,h as D,j as T,k as M,o as ee,l as N,m as A,n as x,p as a,q as n,r as F,u as H,v as q,w as I,x as j,y as k}from"./index2.js";import{g as le,A as C}from"./Arrow.js";function te(p){_(p,"svelte-1285zfm",".summaryMain.svelte-1285zfm.svelte-1285zfm{padding:0 48px;height:100%;display:flex;flex-direction:column;color:#09341FCC}.summaryMain.svelte-1285zfm hr.svelte-1285zfm{border:2px solid rgba(201, 219, 210, 1);border-radius:2px;margin:18px 0}.summaryMain.svelte-1285zfm h5.svelte-1285zfm{font-size:16px;margin:0}.summaryMain.svelte-1285zfm ul.svelte-1285zfm{margin-top:4px;margin-bottom:24px;font-size:14px;padding-left:20px}.summaryMain.svelte-1285zfm ul li.svelte-1285zfm:not(:first-child){margin-top:4px}.summaryHeader.svelte-1285zfm.svelte-1285zfm{width:100%;font-size:16px;line-height:115%;padding-top:32px;display:flex;align-items:center;transform:translateX(-48px)}.summaryBody.svelte-1285zfm.svelte-1285zfm{width:100%;height:100%;margin:auto}.summaryBody.svelte-1285zfm a.svelte-1285zfm{display:block;color:#E66439;font-weight:bold;font-size:12px;margin-top:12px}.summaryBody.svelte-1285zfm p.svelte-1285zfm{color:rgba(9, 52, 31, 0.80);font-size:10px;margin-top:6px}.main.svelte-1285zfm.svelte-1285zfm{height:100%;width:100%;display:flex}.label.svelte-1285zfm.svelte-1285zfm{width:30%;display:flex;align-items:center}.header.svelte-1285zfm.svelte-1285zfm{width:100%;height:100%;display:flex;align-items:center}")}function se(p){let e,l,t,r,h,d=p[1]==="mature"&&E(p),i=p[1]==="median"&&J(p),o=p[1]==="youth"&&X(p),v=p[1]==="shield"&&O(p);return{c(){d&&d.c(),e=L(),i&&i.c(),l=L(),o&&o.c(),t=L(),v&&v.c(),r=P()},m(s,m){d&&d.m(s,m),G(s,e,m),i&&i.m(s,m),G(s,l,m),o&&o.m(s,m),G(s,t,m),v&&v.m(s,m),G(s,r,m),h=!0},p(s,m){s[1]==="mature"?d?(d.p(s,m),m&2&&T(d,1)):(d=E(s),d.c(),T(d,1),d.m(e.parentNode,e)):d&&(N(),Z(d,1,1,()=>{d=null}),D()),s[1]==="median"?i?(i.p(s,m),m&2&&T(i,1)):(i=J(s),i.c(),T(i,1),i.m(l.parentNode,l)):i&&(N(),Z(i,1,1,()=>{i=null}),D()),s[1]==="youth"?o?(o.p(s,m),m&2&&T(o,1)):(o=X(s),o.c(),T(o,1),o.m(t.parentNode,t)):o&&(N(),Z(o,1,1,()=>{o=null}),D()),s[1]==="shield"?v?(v.p(s,m),m&2&&T(v,1)):(v=O(s),v.c(),T(v,1),v.m(r.parentNode,r)):v&&(N(),Z(v,1,1,()=>{v=null}),D())},i(s){h||(T(d),T(i),T(o),T(v),h=!0)},o(s){Z(d),Z(i),Z(o),Z(v),h=!1},d(s){s&&(M(e),M(l),M(t),M(r)),d&&d.d(s),i&&i.d(s),o&&o.d(s),v&&v.d(s)}}}function ie(p){let e,l,t,r,h,d,i=p[2]?"Major overlap":p[3]?"Some overlap":"No significant overlap",o,v,s,m,b,f,u,w;function c(z,B){return z[2]||z[3]?re:ae}let y=c(p),$=y(p);return{c(){e=g("div"),l=g("div"),t=g("div"),$.c(),r=L(),h=g("div"),d=g("b"),o=A(i),v=A(" of glycan indexes between "),s=g("br"),m=A(" your patient and this condition."),b=L(),f=g("hr"),u=L(),w=g("div"),w.innerHTML='<h5 class="svelte-1285zfm">Signs and symptoms</h5> <ul class="svelte-1285zfm"><li class="svelte-1285zfm">Joint pain, swelling, stiffness and erythema</li> <li class="svelte-1285zfm">Smaller and distant joint involvement (fingers, toes), usually symmetrical</li> <li class="svelte-1285zfm">Systemic (fatigue, weight loss, etc.)</li></ul> <h5 class="svelte-1285zfm">Possible follow-up</h5> <ul class="svelte-1285zfm"><li class="svelte-1285zfm">Blood tests: full blood count, rheumatoid factor, anti-CCP antibodies, CRP</li> <li class="svelte-1285zfm">Joint imaging (X-rays, MRI)</li></ul> <h5 class="svelte-1285zfm">Related research papers</h5> <div><a href="https://pubmed.ncbi.nlm.nih.gov/24016253/" class="svelte-1285zfm">Association between galactosylation of immunoglobulin G and improvement of rheumatoid arthritis during pregnancy is independent of sialylation</a> <p class="svelte-1285zfm">In an investigation focusing on IgG glycosylation in pregnant Caucasian women with an average age of 32 suffering from RA compared to a healthy control group, utilizing a cohort of 251 participants, the study identified an elevation in G0 and B, contrasted with a decrease in G1, G2, and S in the RA group. During the entire course of pregnancy and the postpartum period, a consistent reduction in galactosylation and sialylation was observed among the RA patients.</p> <a href="https://pubmed.ncbi.nlm.nih.gov/28793911/" class="svelte-1285zfm">IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis</a> <p class="svelte-1285zfm">In a study of Swedish patients with early rheumatoid arthritis (RA), 73% of whom were women with an average age of 53, compared to a control group comprising 72% women with an average age of 54, an increase in G0 was observed, while G1 and G2 were decreased. No changes were noted in B and S.</p> <a href="https://pubmed.ncbi.nlm.nih.gov/29572115/" class="svelte-1285zfm">Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up</a> <p class="svelte-1285zfm">In an extensive study which encompassed two Finnish cohorts totaling 14,749 individuals, 179 subjects who developed rheumatoid arthritis (RA) were monitored over a 10-year period alongside 358 matched controls, 59% of whom were female. The analysis uncovered a reduction in G0 and an elevation in G1, with a nominally significant decrease observed in G2 and S; B was not assessed. Notably, the research identified a specific G0 glycan peak as a crucial pre-existing risk factor for the onset of RA.</p></div>',x(t,"transform","translate(-50%)"),x(d,"color",p[2]||p[3]?"#F2590D":"#12A195"),a(l,"class","summaryHeader svelte-1285zfm"),a(f,"class","svelte-1285zfm"),a(w,"class","summaryBody svelte-1285zfm"),a(e,"class","summaryMain svelte-1285zfm")},m(z,B){G(z,e,B),n(e,l),n(l,t),$.m(t,null),n(l,r),n(l,h),n(h,d),n(d,o),n(h,v),n(h,s),n(h,m),n(e,b),n(e,f),n(e,u),n(e,w)},p(z,B){y!==(y=c(z))&&($.d(1),$=y(z),$&&($.c(),$.m(t,null))),B&12&&i!==(i=z[2]?"Major overlap":z[3]?"Some overlap":"No significant overlap")&&F(o,i),B&12&&x(d,"color",z[2]||z[3]?"#F2590D":"#12A195")},i:H,o:H,d(z){z&&M(e),$.d()}}}function ne(p){let e,l,t,r,h,d,i,o=p[2]?"Major overlap":p[3]?"Some overlap":"No significant overlap",v;function s(f,u){return f[2]||f[3]?me:oe}let m=s(p),b=m(p);return{c(){e=g("div"),l=g("div"),t=g("b"),r=A(p[8]),h=A("/4"),d=L(),b.c(),i=A(`
2
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During the entire course of pregnancy and the postpartum period, a consistent reduction in galactosylation and sialylation was observed among the RA patients.</p> <a href="https://pubmed.ncbi.nlm.nih.gov/28793911/" class="svelte-1285zfm">IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis</a> <p class="svelte-1285zfm">In a study of Swedish patients with early rheumatoid arthritis (RA), 73% of whom were women with an average age of 53, compared to a control group comprising 72% women with an average age of 54, an increase in G0 was observed, while G1 and G2 were decreased. No changes were noted in B and S.</p> <a href="https://pubmed.ncbi.nlm.nih.gov/29572115/" class="svelte-1285zfm">Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up</a> <p class="svelte-1285zfm">In an extensive study which encompassed two Finnish cohorts totaling 14,749 individuals, 179 subjects who developed rheumatoid arthritis (RA) were monitored over a 10-year period alongside 358 matched controls, 59% of whom were female. The analysis uncovered a reduction in G0 and an elevation in G1, with a nominally significant decrease observed in G2 and S; B was not assessed. 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A decrease in G1, G2 and S was observed, alongside an increase in G0 and B. These findings were replicated in 967 women from the ORCADES cohort (Orkney Complex Disease Study). 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Observed alterations of specific glycan peaks demonstrated predictive power, with an area under the curve (AUC) of 0.72, indicating their potential utility in distinguishing between UC patients and healthy individuals.</p> <a href="https://pubmed.ncbi.nlm.nih.gov/29309774/" class="svelte-1285zfm">Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases</a> <p class="svelte-1285zfm">In a comprehensive study examining IgG glycosylation patterns in IBS, a cohort including 1,056 UC patients from Italy, 253 from the US, and controls (427 in Italy and 440 from the US) was analyzed. The average age of participants was 39, with a balanced gender distribution. The findings showed a decrease in G1, G2, and B glycan traits and an increase in G0 across UC patients. The glycosylation traits were incorporated into a model that demonstrated significant predictive capability with an AUC of 0.814. 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