@genspectrum/dashboard-components 0.1.1 → 0.1.3

package/dist/dashboard-components.js.map

@@ -1 +1 @@
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* @license\n * Copyright 2017 Google LLC\n * SPDX-License-Identifier: BSD-3-Clause\n */\nconst t=t=>(e,o)=>{void 0!==o?o.addInitializer((()=>{customElements.define(t,e)})):customElements.define(t,e)};export{t as customElement};\n//# sourceMappingURL=custom-element.js.map\n","/**\n * @license\n * Copyright 2019 Google LLC\n * SPDX-License-Identifier: BSD-3-Clause\n */\nconst t=globalThis,e=t.ShadowRoot&&(void 0===t.ShadyCSS||t.ShadyCSS.nativeShadow)&&\"adoptedStyleSheets\"in Document.prototype&&\"replace\"in CSSStyleSheet.prototype,s=Symbol(),o=new WeakMap;class n{constructor(t,e,o){if(this._$cssResult$=!0,o!==s)throw Error(\"CSSResult is not constructable. 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s=this._$AL;try{t=this.shouldUpdate(s),t?(this.willUpdate(s),this._$EO?.forEach((t=>t.hostUpdate?.())),this.update(s)):this._$EU()}catch(s){throw t=!1,this._$EU(),s}t&&this._$AE(s)}willUpdate(t){}_$AE(t){this._$EO?.forEach((t=>t.hostUpdated?.())),this.hasUpdated||(this.hasUpdated=!0,this.firstUpdated(t)),this.updated(t)}_$EU(){this._$AL=new Map,this.isUpdatePending=!1}get updateComplete(){return this.getUpdateComplete()}getUpdateComplete(){return this._$ES}shouldUpdate(t){return!0}update(t){this._$Ej&&=this._$Ej.forEach((t=>this._$EC(t,this[t]))),this._$EU()}updated(t){}firstUpdated(t){}}b.elementStyles=[],b.shadowRootOptions={mode:\"open\"},b[d(\"elementProperties\")]=new Map,b[d(\"finalized\")]=new Map,p?.({ReactiveElement:b}),(a.reactiveElementVersions??=[]).push(\"2.0.4\");export{b as ReactiveElement,u as defaultConverter,f as notEqual};\n//# sourceMappingURL=reactive-element.js.map\n","import{defaultConverter as t,notEqual as e}from\"../reactive-element.js\";\n/**\n * @license\n * Copyright 2017 Google LLC\n * SPDX-License-Identifier: BSD-3-Clause\n */const o={attribute:!0,type:String,converter:t,reflect:!1,hasChanged:e},r=(t=o,e,r)=>{const{kind:n,metadata:i}=r;let s=globalThis.litPropertyMetadata.get(i);if(void 0===s&&globalThis.litPropertyMetadata.set(i,s=new Map),s.set(r.name,t),\"accessor\"===n){const{name:o}=r;return{set(r){const n=e.get.call(this);e.set.call(this,r),this.requestUpdate(o,n,t)},init(e){return void 0!==e&&this.P(o,void 0,t),e}}}if(\"setter\"===n){const{name:o}=r;return function(r){const n=this[o];e.call(this,r),this.requestUpdate(o,n,t)}}throw Error(\"Unsupported decorator location: \"+n)};function n(t){return(e,o)=>\"object\"==typeof o?r(t,e,o):((t,e,o)=>{const r=e.hasOwnProperty(o);return e.constructor.createProperty(o,r?{...t,wrapped:!0}:t),r?Object.getOwnPropertyDescriptor(e,o):void 0})(t,e,o)}export{n as property,r as standardProperty};\n//# sourceMappingURL=property.js.map\n","import { createContext } from '@lit/context';\n\nexport const lapisContext = createContext<string>('lapis-context');\n","import { createContext } from '@lit/context';\n\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\n\nexport const referenceGenomeContext = createContext<ReferenceGenome>('reference-genome-context');\n","import z from 'zod';\n\nimport type { SequenceType } from '../types';\n\nexport const referenceGenomeResponse = z.object({\n    nucleotideSequences: z.array(\n        z.object({\n            name: z.string(),\n            sequence: z.string(),\n        }),\n    ),\n    genes: z.array(\n        z.object({\n            name: z.string(),\n            sequence: z.string(),\n        }),\n    ),\n});\nexport type ReferenceGenome = z.infer<typeof referenceGenomeResponse>;\n\nexport const getSegmentNames = (referenceGenome: ReferenceGenome, sequenceType: SequenceType) => {\n    switch (sequenceType) {\n        case 'nucleotide': {\n            return referenceGenome.nucleotideSequences.map((sequence) => sequence.name);\n        }\n        case 'amino acid': {\n            return referenceGenome.genes.map((gene) => gene.name);\n        }\n    }\n};\n","import z, { type ZodTypeAny } from 'zod';\n\nexport const orderByType = z.enum(['ascending', 'descending']);\n\nexport const orderBy = z.object({\n    field: z.string(),\n    type: orderByType,\n});\n\nexport const lapisBaseRequest = z\n    .object({\n        limit: z.number().optional(),\n        offset: z.number().optional(),\n        fields: z.array(z.string()).optional(),\n        orderBy: z.array(orderBy).optional(),\n    })\n    .catchall(z.union([z.boolean(), z.undefined(), z.string(), z.number(), z.null(), z.array(z.string())]));\nexport type LapisBaseRequest = z.infer<typeof lapisBaseRequest>;\n\nexport const mutationsRequest = lapisBaseRequest.extend({ minProportion: z.number().optional() });\nexport type MutationsRequest = z.infer<typeof mutationsRequest>;\n\nconst mutationProportionCount = z.object({\n    mutation: z.string(),\n    proportion: z.number(),\n    count: z.number(),\n    sequenceName: z.union([z.string(), z.null()]),\n    mutationFrom: z.string(),\n    mutationTo: z.string(),\n    position: z.number(),\n});\nexport const mutationsResponse = makeLapisResponse(z.array(mutationProportionCount));\n\nconst insertionCount = z.object({\n    insertion: z.string(),\n    count: z.number(),\n    insertedSymbols: z.string(),\n    position: z.number(),\n    sequenceName: z.union([z.string(), z.null()]),\n});\nexport const insertionsResponse = makeLapisResponse(z.array(insertionCount));\n\nexport const aggregatedItem = z.object({ count: z.number() }).catchall(z.union([z.string(), z.number(), z.null()]));\nexport const aggregatedResponse = makeLapisResponse(z.array(aggregatedItem));\nexport type AggregatedItem = z.infer<typeof aggregatedItem>;\n\nfunction makeLapisResponse<T extends ZodTypeAny>(data: T) {\n    return z.object({\n        data,\n    });\n}\n","import { referenceGenomeResponse } from './ReferenceGenome';\nimport {\n    aggregatedResponse,\n    insertionsResponse,\n    type LapisBaseRequest,\n    type MutationsRequest,\n    mutationsResponse,\n} from './lapisTypes';\nimport { type SequenceType } from '../types';\n\nexport async function fetchAggregated(lapisUrl: string, body: LapisBaseRequest, signal?: AbortSignal) {\n    const response = await fetch(aggregatedEndpoint(lapisUrl), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return aggregatedResponse.parse(await response.json());\n}\n\nexport async function fetchInsertions(\n    lapisUrl: string,\n    body: LapisBaseRequest,\n    sequenceType: SequenceType,\n    signal?: AbortSignal,\n) {\n    const response = await fetch(insertionsEndpoint(lapisUrl, sequenceType), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return insertionsResponse.parse(await response.json());\n}\n\nexport async function fetchSubstitutionsOrDeletions(\n    lapisUrl: string,\n    body: MutationsRequest,\n    sequenceType: SequenceType,\n    signal?: AbortSignal,\n) {\n    const response = await fetch(substitutionsOrDeletionsEndpoint(lapisUrl, sequenceType), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return mutationsResponse.parse(await response.json());\n}\n\nexport async function fetchReferenceGenome(lapisUrl: string, signal?: AbortSignal) {\n    const response = await fetch(referenceGenomeEndpoint(lapisUrl), {\n        method: 'GET',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        signal,\n    });\n\n    await handleErrors(response);\n    return referenceGenomeResponse.parse(await response.json());\n}\n\nconst handleErrors = async (response: Response) => {\n    if (!response.ok) {\n        if (response.status % 500 === 0) {\n            throw new Error(`${response.statusText}: ${JSON.stringify(await response.json())}`);\n        }\n        throw new Error(`${response.statusText}: ${response.status}`);\n    }\n};\n\nexport const aggregatedEndpoint = (lapisUrl: string) => `${lapisUrl}/sample/aggregated`;\nexport const insertionsEndpoint = (lapisUrl: string, sequenceType: SequenceType) => {\n    return sequenceType === 'amino acid'\n        ? `${lapisUrl}/sample/aminoAcidInsertions`\n        : `${lapisUrl}/sample/nucleotideInsertions`;\n};\nexport const substitutionsOrDeletionsEndpoint = (lapisUrl: string, sequenceType: SequenceType) => {\n    return sequenceType === 'amino acid'\n        ? `${lapisUrl}/sample/aminoAcidMutations`\n        : `${lapisUrl}/sample/nucleotideMutations`;\n};\nexport const referenceGenomeEndpoint = (lapisUrl: string) => `${lapisUrl}/sample/referenceGenome`;\n","import { provide } from '@lit/context';\nimport { Task } from '@lit/task';\nimport { html, LitElement } from 'lit';\nimport { customElement, property } from 'lit/decorators.js';\n\nimport { lapisContext } from './lapis-context';\nimport { referenceGenomeContext } from './reference-genome-context';\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\nimport { fetchReferenceGenome } from '../lapisApi/lapisApi';\n\n@customElement('gs-app')\nexport class App extends LitElement {\n    @provide({ context: lapisContext })\n    @property()\n    lapis: string = '';\n\n    @provide({ context: referenceGenomeContext })\n    referenceGenome: ReferenceGenome = {\n        nucleotideSequences: [],\n        genes: [],\n    };\n\n    private updateReferenceGenome = new Task(this, {\n        task: async () => {\n            this.referenceGenome = await fetchReferenceGenome(this.lapis);\n        },\n        args: () => [this.lapis],\n    });\n\n    override render() {\n        return this.updateReferenceGenome.render({\n            complete: () => {\n                return html` <slot></slot>`;\n            },\n            error: () => html`<p>Error</p>`, // TODO(#143): Add more advanced error handling\n            pending: () => {\n                return html`<p>Loading...</p>`;\n            },\n        });\n    }\n\n    override createRenderRoot() {\n        return this;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-app': App;\n    }\n}\n","import{options as r,Fragment as e}from\"preact\";export{Fragment}from\"preact\";var t=/[\"&<]/;function n(r){if(0===r.length||!1===t.test(r))return r;for(var e=0,n=0,o=\"\",f=\"\";n<r.length;n++){switch(r.charCodeAt(n)){case 34:f=\"&quot;\";break;case 38:f=\"&amp;\";break;case 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i=(r=n.__c).__H;i&&(u===r?(i.__h=[],r.__h=[],i.__.forEach(function(n){n.__N&&(n.__=n.__N),n.__V=c,n.__N=n.i=void 0})):(i.__h.forEach(z),i.__h.forEach(B),i.__h=[],t=0)),u=r},e.diffed=function(n){l&&l(n);var t=n.__c;t&&t.__H&&(t.__H.__h.length&&(1!==f.push(t)&&i===e.requestAnimationFrame||((i=e.requestAnimationFrame)||w)(j)),t.__H.__.forEach(function(n){n.i&&(n.__H=n.i),n.__V!==c&&(n.__=n.__V),n.i=void 0,n.__V=c})),u=r=null},e.__c=function(n,t){t.some(function(n){try{n.__h.forEach(z),n.__h=n.__h.filter(function(n){return!n.__||B(n)})}catch(r){t.some(function(n){n.__h&&(n.__h=[])}),t=[],e.__e(r,n.__v)}}),m&&m(n,t)},e.unmount=function(n){s&&s(n);var t,r=n.__c;r&&r.__H&&(r.__H.__.forEach(function(n){try{z(n)}catch(n){t=n}}),r.__H=void 0,t&&e.__e(t,r.__v))};var k=\"function\"==typeof requestAnimationFrame;function w(n){var t,r=function(){clearTimeout(u),k&&cancelAnimationFrame(t),setTimeout(n)},u=setTimeout(r,100);k&&(t=requestAnimationFrame(r))}function z(n){var t=r,u=n.__c;\"function\"==typeof u&&(n.__c=void 0,u()),r=t}function B(n){var t=r;n.__c=n.__(),r=t}function C(n,t){return!n||n.length!==t.length||t.some(function(t,r){return t!==n[r]})}function D(n,t){return\"function\"==typeof t?t(n):t}export{x as useCallback,P as useContext,V as useDebugValue,_ as useEffect,b as useErrorBoundary,g as useId,T as useImperativeHandle,A as useLayoutEffect,q as useMemo,y as useReducer,F as useRef,p as useState};\n//# sourceMappingURL=hooks.module.js.map\n","import { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\ntype Proportions = {\n    [displayName: string]: number;\n};\n\nexport function getMutationComparisonTableData(data: Dataset<MutationData>, proportionInterval: ProportionInterval) {\n    const mutationsToProportions = new Map<string, Proportions>();\n\n    for (const mutationData of data.content) {\n        for (const mutationEntry of mutationData.data) {\n            const mutation = mutationEntry.mutation.toString();\n            const proportions = mutationsToProportions.get(mutation) || {};\n            proportions[mutationData.displayName] = mutationEntry.proportion;\n            mutationsToProportions.set(mutation, proportions);\n        }\n    }\n\n    return [...mutationsToProportions.entries()]\n        .map(([mutation, proportions]) => {\n            return {\n                mutation,\n                ...data.content\n                    .map((mutationData) => {\n                        return {\n                            [`${mutationData.displayName} prevalence`]: proportions[mutationData.displayName] || 0,\n                        };\n                    })\n                    .reduce((acc, val) => ({ ...acc, ...val }), {}),\n            } as { mutation: string } & Proportions;\n        })\n        .filter((row) =>\n            Object.values(row).some(\n                (value) =>\n                    typeof value === 'number' && value >= proportionInterval.min && value <= proportionInterval.max,\n            ),\n        );\n}\n","import { Grid } from 'gridjs';\nimport { type OneDArray, type TColumn, type TData } from 'gridjs/dist/src/types';\nimport { type PaginationConfig } from 'gridjs/dist/src/view/plugin/pagination';\nimport { type ComponentChild } from 'preact';\nimport { useEffect, useRef } from 'preact/hooks';\nimport 'gridjs/dist/theme/mermaid.css';\n\nexport const tableStyle = {\n    table: {\n        fontSize: '12px',\n    },\n    th: {\n        padding: '4px',\n        textAlign: 'center',\n    },\n    td: {\n        textAlign: 'center',\n        padding: '8px',\n    },\n    footer: {\n        fontSize: '12px',\n    },\n};\n\ninterface TableProps {\n    data: TData;\n    columns: OneDArray<TColumn | string | ComponentChild>;\n    pagination: PaginationConfig | boolean;\n}\n\nexport const Table = ({ data, columns, pagination }: TableProps) => {\n    const wrapper = useRef(null);\n\n    useEffect(() => {\n        if (wrapper.current === null) {\n            return;\n        }\n        const grid = new Grid({\n            columns,\n            data,\n            style: tableStyle,\n            pagination,\n        }).render(wrapper.current);\n\n        return () => {\n            grid.destroy();\n        };\n    });\n\n    return <div ref={wrapper} />;\n};\n","export const substitutionAndDeletionRegex = /(?:([A-Za-z0-9]+):)?([A-Za-z])(\\d+)([A-Za-z]|-|\\*)/;\n\nexport const sortSubstitutionsAndDeletions = (a: string, b: string) => {\n    const aMatch = a.match(substitutionAndDeletionRegex);\n    const bMatch = b.match(substitutionAndDeletionRegex);\n\n    if (aMatch && bMatch) {\n        if (aMatch[1] !== bMatch[1]) {\n            return aMatch[1].localeCompare(bMatch[1]);\n        }\n        if (aMatch[3] !== bMatch[3]) {\n            return parseInt(aMatch[3], 10) - parseInt(bMatch[3], 10);\n        }\n        return aMatch[4].localeCompare(bMatch[4]);\n    }\n    throw new Error(`Invalid substitution or deletion: ${a} or ${b}`);\n};\n","export const formatProportion = (proportion: number) => {\n    return `${(proportion * 100).toFixed(2)}%`;\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getMutationComparisonTableData } from './getMutationComparisonTableData';\nimport { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { Table } from '../components/table';\nimport { sortSubstitutionsAndDeletions } from '../shared/sort/sortSubstitutionsAndDeletions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\nexport interface MutationsTableProps {\n    data: Dataset<MutationData>;\n    proportionInterval: ProportionInterval;\n}\n\nexport const MutationComparisonTable: FunctionComponent<MutationsTableProps> = ({ data, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Mutation',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortSubstitutionsAndDeletions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Prevalence',\n                columns: data.content.map((mutationData) => {\n                    return {\n                        name: mutationData.displayName,\n                        sort: true,\n                        formatter: (cell: number) => formatProportion(cell),\n                    };\n                }),\n            },\n        ];\n    };\n\n    const tableData = getMutationComparisonTableData(data, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { Chart, type ChartConfiguration } from 'chart.js';\nimport { useEffect, useRef } from 'preact/hooks';\n\nexport interface GsChartProps {\n    configuration: ChartConfiguration;\n}\n\nconst GsChart = ({ configuration }: GsChartProps) => {\n    const canvasRef = useRef<HTMLCanvasElement>(null);\n    const chartRef = useRef<Chart | null>(null);\n\n    useEffect(() => {\n        if (canvasRef.current === null) {\n            return;\n        }\n\n        const ctx = canvasRef.current.getContext('2d');\n        if (ctx === null) {\n            return;\n        }\n\n        chartRef.current = new Chart(ctx, configuration);\n\n        return () => {\n            chartRef.current?.destroy();\n        };\n    }, [canvasRef, configuration]);\n\n    return <canvas ref={canvasRef} />;\n};\n\nexport default GsChart;\n","import { type ActiveElement, Chart, type ChartConfiguration, type ChartEvent, registerables } from 'chart.js';\nimport { ArcSlice, extractSets, VennDiagramController } from 'chartjs-chart-venn';\nimport { type FunctionComponent } from 'preact';\nimport { useEffect, useMemo, useRef, useState } from 'preact/hooks';\n\nimport { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport GsChart from '../components/chart';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\nChart.register(...registerables, VennDiagramController, ArcSlice);\n\nexport interface MutationComparisonVennProps {\n    data: Dataset<MutationData>;\n    proportionInterval: ProportionInterval;\n}\n\nexport const MutationComparisonVenn: FunctionComponent<MutationComparisonVennProps> = ({\n    data,\n    proportionInterval,\n}) => {\n    const divRef = useRef<HTMLDivElement>(null);\n    const noElementSelectedMessage = 'You have no elements selected. Click in the venn diagram to select.';\n    const [selectedDatasetIndex, setSelectedDatasetIndex] = useState<null | number>(null);\n\n    const sets = useMemo(\n        () =>\n            extractSets(\n                data.content\n                    .map((mutationData) => ({\n                        displayName: mutationData.displayName,\n                        data: mutationData.data.filter(\n                            (mutationEntry) =>\n                                mutationEntry.proportion >= proportionInterval.min &&\n                                mutationEntry.proportion <= proportionInterval.max,\n                        ),\n                    }))\n                    .map((mutationData) => {\n                        return {\n                            label: mutationData.displayName,\n                            values: mutationData.data.map((mutationEntry) => mutationEntry.mutation.toString()),\n                        };\n                    }),\n            ),\n        [data, proportionInterval],\n    );\n\n    useEffect(() => {\n        if (divRef.current === null) {\n            return;\n        }\n        if (selectedDatasetIndex === null) {\n            divRef.current.innerText = noElementSelectedMessage;\n            return;\n        }\n\n        const values = sets.datasets[0].data[selectedDatasetIndex].values;\n        const label = sets.datasets[0].data[selectedDatasetIndex].label;\n        divRef.current!.innerText = `${label}: ${values.join(', ')}` || '';\n    }, [divRef, selectedDatasetIndex, sets]);\n\n    const config: ChartConfiguration = useMemo(\n        () => ({\n            type: 'venn',\n            data: sets,\n            options: {\n                scales: {\n                    x: {\n                        ticks: {\n                            color: 'black',\n                            font: {\n                                size: 20,\n                            },\n                        },\n                    },\n                    y: {\n                        ticks: {\n                            color: 'blue',\n                            font: {\n                                size: 20,\n                            },\n                        },\n                    },\n                },\n                events: ['click'],\n                onClick(_: ChartEvent, elements: ActiveElement[]) {\n                    if (elements.length === 0) {\n                        setSelectedDatasetIndex(null);\n                    }\n                },\n                backgroundColor: '#f5f5f5',\n                animation: false,\n                layout: {\n                    padding: 30,\n                },\n                plugins: {\n                    legend: {\n                        display: false,\n                    },\n                    tooltip: {\n                        filter: ({ dataIndex }) => {\n                            setSelectedDatasetIndex(dataIndex);\n                            return false;\n                        },\n                    },\n                },\n            },\n        }),\n        [sets],\n    );\n\n    if (data.content.length > 5) {\n        return <div>Too many variants to display. Maximum are five. </div>;\n    }\n\n    return (\n        <>\n            <GsChart configuration={config} />\n            <div class='flex flex-wrap break-words m-2' ref={divRef} />\n        </>\n    );\n};\n","import { type SequenceType } from '../types';\n\nexport interface Mutation {\n    readonly segment: string | undefined;\n    readonly position: number;\n    readonly code: string;\n\n    equals(other: Mutation): boolean;\n\n    toString(): string;\n}\n\nexport const substitutionRegex =\n    /^((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<valueAtReference>[A-Za-z])?(?<position>\\d+)(?<substitutionValue>[A-Za-z.])?$/;\n\nexport class Substitution implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly valueAtReference: string | undefined,\n        readonly substitutionValue: string | undefined,\n        readonly position: number,\n    ) {\n        const segmentString = this.segment ? `${this.segment}:` : '';\n        const valueAtReferenceString = this.valueAtReference ? `${this.valueAtReference}` : '';\n        const substitutionValueString = this.substitutionValue ? `${this.substitutionValue}` : '';\n        this.code = `${segmentString}${valueAtReferenceString}${this.position}${substitutionValueString}`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Substitution)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.valueAtReference === other.valueAtReference &&\n            this.substitutionValue === other.substitutionValue &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Substitution | null {\n        const match = mutationStr.match(substitutionRegex);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n        return new Substitution(\n            match.groups.segment,\n            match.groups.valueAtReference,\n            match.groups.substitutionValue,\n            parseInt(match.groups.position, 10),\n        );\n    }\n}\n\nexport const deletionRegex = /^((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<valueAtReference>[A-Za-z])?(?<position>\\d+)(-)$/;\n\nexport class Deletion implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly valueAtReference: string | undefined,\n        readonly position: number,\n    ) {\n        const segmentString = this.segment ? `${this.segment}:` : '';\n        const valueAtReferenceString = this.valueAtReference ? `${this.valueAtReference}` : '';\n        this.code = `${segmentString}${valueAtReferenceString}${this.position}-`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Deletion)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.valueAtReference === other.valueAtReference &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Deletion | null {\n        const match = mutationStr.match(deletionRegex);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n\n        return new Deletion(match.groups.segment, match.groups.valueAtReference, parseInt(match.groups.position, 10));\n    }\n}\n\nexport const insertionRegexp =\n    /^ins_((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<position>\\d+):(?<insertedSymbols>(([A-Za-z?]|(\\.\\*))+))$/i;\n\nexport class Insertion implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly position: number,\n        readonly insertedSymbols: string,\n    ) {\n        this.code = `ins_${this.segment ? `${this.segment}:` : ''}${this.position}:${this.insertedSymbols}`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Insertion)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.insertedSymbols === other.insertedSymbols &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Insertion | null {\n        const match = mutationStr.match(insertionRegexp);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n\n        return new Insertion(match.groups.segment, parseInt(match.groups.position, 10), match.groups.insertedSymbols);\n    }\n}\n\nexport const bases: { [P in SequenceType]: string[] } = {\n    nucleotide: ['A', 'C', 'G', 'T', '-'],\n    'amino acid': [\n        'I',\n        'L',\n        'V',\n        'F',\n        'M',\n        'C',\n        'A',\n        'G',\n        'P',\n        'T',\n        'S',\n        'Y',\n        'W',\n        'Q',\n        'N',\n        'H',\n        'E',\n        'D',\n        'K',\n        'R',\n        '-',\n    ],\n};\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchSubstitutionsOrDeletions } from '../lapisApi/lapisApi';\nimport { type LapisFilter, type SequenceType, type SubstitutionOrDeletionEntry } from '../types';\nimport { Deletion, Substitution } from '../utils/mutations';\n\nexport class FetchSubstitutionsOrDeletionsOperator implements Operator<SubstitutionOrDeletionEntry> {\n    constructor(\n        private filter: LapisFilter,\n        private sequenceType: SequenceType,\n        private minProportion?: number,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<SubstitutionOrDeletionEntry>> {\n        const mutations = await this.fetchMutations(lapis, signal);\n\n        const content: SubstitutionOrDeletionEntry[] = mutations.map(\n            ({ count, proportion, mutationFrom, mutationTo, position, sequenceName }) => {\n                if (mutationTo === '-') {\n                    return {\n                        type: 'deletion',\n                        mutation: new Deletion(sequenceName ?? undefined, mutationFrom, position),\n                        count,\n                        proportion,\n                    };\n                }\n                return {\n                    type: 'substitution',\n                    mutation: new Substitution(sequenceName ?? undefined, mutationFrom, mutationTo, position),\n                    count,\n                    proportion,\n                };\n            },\n        );\n\n        return { content };\n    }\n\n    private async fetchMutations(lapis: string, signal?: AbortSignal) {\n        const filter = {\n            ...this.filter,\n            minProportion: this.minProportion,\n        };\n\n        return fetchSubstitutionsOrDeletions(lapis, filter, this.sequenceType, signal).then(\n            (response) => response.data,\n        );\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class SortOperator<S> implements Operator<S> {\n    constructor(\n        private child: Operator<S>,\n        private compareFn: (a: S, b: S) => number,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<S>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        return {\n            content: childEvaluated.content.sort(this.compareFn),\n        };\n    }\n}\n","import { FetchSubstitutionsOrDeletionsOperator } from '../operator/FetchSubstitutionsOrDeletionsOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type SequenceType } from '../types';\n\nexport function querySubstitutionsOrDeletions(\n    variant: LapisFilter,\n    sequenceType: SequenceType,\n    lapis: string,\n    signal?: AbortSignal,\n) {\n    const fetchData = new FetchSubstitutionsOrDeletionsOperator(variant, sequenceType, 0);\n    const sortData = new SortOperator(fetchData, (a, b) => {\n        if (a.mutation.segment !== b.mutation.segment) {\n            return (a.mutation.segment ?? '').localeCompare(b.mutation.segment ?? '');\n        }\n        return a.mutation.position - b.mutation.position;\n    });\n    return sortData.evaluate(lapis, signal);\n}\n","import { type MutationComparisonVariant } from './mutation-comparison';\nimport { querySubstitutionsOrDeletions } from '../../query/querySubstitutionsOrDeletions';\nimport { type SubstitutionOrDeletionEntry } from '../../types';\nimport { type DisplayedSegment } from '../components/SegmentSelector';\nimport { type DisplayedMutationType } from '../components/mutation-type-selector';\n\nexport type MutationData = {\n    displayName: string;\n    data: SubstitutionOrDeletionEntry[];\n};\n\nexport async function queryMutationData(\n    variants: MutationComparisonVariant[],\n    sequenceType: 'nucleotide' | 'amino acid',\n    lapis: string,\n) {\n    const mutationData = await Promise.all(\n        variants.map(async (variant) => {\n            return {\n                displayName: variant.displayName,\n                data: (await querySubstitutionsOrDeletions(variant.lapisFilter, sequenceType, lapis)).content,\n            };\n        }),\n    );\n    return { mutationData };\n}\n\nexport function filterMutationData(\n    data: MutationData[],\n    displayedSegments: DisplayedSegment[],\n    displayedMutationTypes: DisplayedMutationType[],\n) {\n    const byDisplayedSegments = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        if (mutationEntry.mutation.segment === undefined) {\n            return true;\n        }\n        return displayedSegments.some(\n            (displayedSegment) =>\n                displayedSegment.segment === mutationEntry.mutation.segment && displayedSegment.checked,\n        );\n    };\n    const byDisplayedMutationTypes = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return displayedMutationTypes.some(\n            (displayedMutationType) =>\n                displayedMutationType.checked && displayedMutationType.type === mutationEntry.type,\n        );\n    };\n\n    return data.map((mutationEntry) => ({\n        displayName: mutationEntry.displayName,\n        data: mutationEntry.data.filter(byDisplayedSegments).filter(byDisplayedMutationTypes),\n    }));\n}\n","import { createContext } from 'preact';\n\nexport const LapisUrlContext = createContext('');\n","export type CheckboxItem = {\n    label: string;\n    checked: boolean;\n};\n\nexport interface CheckboxSelectorProps<Item extends CheckboxItem = CheckboxItem> {\n    className?: string;\n    items: Item[];\n    label: string;\n    setItems: (items: Item[]) => void;\n}\n\nexport const CheckboxSelector = <Item extends CheckboxItem>({\n    className,\n    items,\n    label,\n    setItems,\n}: CheckboxSelectorProps<Item>) => {\n    return (\n        <div class={`dropdown ${className}`}>\n            <div tabIndex={0} role='button' class='btn btn-xs text-nowrap'>\n                {label}\n            </div>\n            <ul tabIndex={0} class='p-2 shadow menu dropdown-content z-[1] bg-base-100 rounded-box'>\n                {items.map((item, index) => (\n                    <li class='flex flex-row items-center' key={item.label}>\n                        <label>\n                            <input\n                                type='checkbox'\n                                id={`item-${index}`}\n                                checked={item.checked}\n                                onChange={() => {\n                                    const newItems = items.map((item, i) =>\n                                        i === index ? { ...item, checked: !item.checked } : item,\n                                    );\n                                    setItems(newItems);\n                                }}\n                            />\n                            {item.label}\n                        </label>\n                    </li>\n                ))}\n            </ul>\n        </div>\n    );\n};\n","import { createContext } from 'preact';\n\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\n\nexport const ReferenceGenomeContext = createContext<ReferenceGenome>({ nucleotideSequences: [], genes: [] });\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport { type CheckboxItem, CheckboxSelector } from './checkbox-selector';\nimport { getSegmentNames } from '../../lapisApi/ReferenceGenome';\nimport { type SequenceType } from '../../types';\nimport { ReferenceGenomeContext } from '../ReferenceGenomeContext';\n\nexport type DisplayedSegment = CheckboxItem & {\n    segment: string;\n};\n\nexport type SegmentSelectorProps = {\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (items: DisplayedSegment[]) => void;\n    prefix?: string;\n};\n\nconst getSegmentSelectorLabel = (displayedSegments: DisplayedSegment[], prefix: string) => {\n    const allSelectedSelected = displayedSegments\n        .filter((segment) => segment.checked)\n        .map((segment) => segment.segment);\n\n    if (allSelectedSelected.length === 0) {\n        return `${prefix}none`;\n    }\n    if (displayedSegments.length === allSelectedSelected.length) {\n        return `${prefix}all`;\n    }\n    return prefix + allSelectedSelected.join(', ');\n};\n\nexport const SegmentSelector: FunctionComponent<SegmentSelectorProps> = ({\n    displayedSegments,\n    setDisplayedSegments,\n    prefix,\n}) => {\n    if (displayedSegments.length <= 1) {\n        return null;\n    }\n\n    return (\n        <CheckboxSelector\n            className='mx-1'\n            items={displayedSegments}\n            label={getSegmentSelectorLabel(displayedSegments, prefix || 'Segments: ')}\n            setItems={(items) => setDisplayedSegments(items)}\n        />\n    );\n};\n\nexport function useDisplayedSegments(sequenceType: SequenceType) {\n    const referenceGenome = useContext(ReferenceGenomeContext);\n\n    const displayedSegments = getSegmentNames(referenceGenome, sequenceType).map((segment) => ({\n        segment,\n        label: segment,\n        checked: true,\n    }));\n\n    return useState<DisplayedSegment[]>(displayedSegments);\n}\n","import { type FunctionComponent } from 'preact';\n\nexport interface CsvDownloadButtonProps {\n    label?: string;\n    filename?: string;\n    getData: () => Record<string, string | number | boolean | null>[];\n    className?: string;\n}\n\nexport const CsvDownloadButton: FunctionComponent<CsvDownloadButtonProps> = ({\n    label = 'Download',\n    filename = 'data.csv',\n    getData,\n    className,\n}) => {\n    const download = () => {\n        const content = getDownloadContent();\n        const blob = new Blob([content], { type: 'text/csv' });\n        const url = URL.createObjectURL(blob);\n        const a = document.createElement('a');\n        a.href = url;\n        a.download = filename;\n        a.click();\n        URL.revokeObjectURL(url);\n    };\n\n    const getDownloadContent = () => {\n        const data = getData();\n        const keys = getDataKeys(data);\n        const header = `${keys.join(',')}\\n`;\n        const rows = data.map((row) => keys.map((key) => row[key]).join(',')).join('\\n');\n        return header + rows;\n    };\n\n    const getDataKeys = (data: Record<string, string | number | boolean | null>[]) => {\n        const keysSet = data\n            .map((row) => Object.keys(row))\n            .reduce((accumulatedKeys, keys) => {\n                keys.forEach((key) => accumulatedKeys.add(key));\n                return accumulatedKeys;\n            }, new Set<string>());\n\n        return [...keysSet];\n    };\n\n    return (\n        <button className={className} onClick={download}>\n            {label}\n        </button>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nexport const ErrorDisplay: FunctionComponent<{ error: Error }> = ({ error }) => {\n    return <div>Error: {error.message}</div>;\n};\n","import { type FunctionComponent } from 'preact';\n\nexport interface HeadlineProps {\n    heading: string;\n}\n\nconst Headline: FunctionComponent<HeadlineProps> = ({ heading, children }) => {\n    return (\n        <>\n            <h1>{heading}</h1>\n            {children}\n        </>\n    );\n};\n\nexport default Headline;\n","import { type FunctionComponent } from 'preact';\n\nexport interface InfoProps {\n    content: string;\n    className?: string;\n}\n\nconst Info: FunctionComponent<InfoProps> = ({ content, className }) => {\n    return (\n        <div class={`${className} tooltip`} data-tip={content}>\n            <button class='btn btn-xs'>?</button>\n        </div>\n    );\n};\n\nexport default Info;\n","import { type FunctionComponent } from 'preact';\n\nexport const LoadingDisplay: FunctionComponent = () => {\n    return <div>Loading...</div>;\n};\n","import { type FunctionComponent } from 'preact/compat';\n\nimport { type CheckboxItem, CheckboxSelector } from './checkbox-selector';\nimport type { SubstitutionOrDeletion } from '../../types';\n\nexport type DisplayedMutationType = CheckboxItem & {\n    type: SubstitutionOrDeletion;\n};\n\nexport type MutationTypeSelectorProps = {\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (mutationTypes: DisplayedMutationType[]) => void;\n};\n\nexport const MutationTypeSelector: FunctionComponent<MutationTypeSelectorProps> = ({\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n}) => {\n    const checkedLabels = displayedMutationTypes.filter((type) => type.checked).map((type) => type.label);\n    const mutationTypesSelectorLabel = `Types: ${checkedLabels.length > 0 ? checkedLabels.join(', ') : 'None'}`;\n\n    return (\n        <CheckboxSelector\n            className='mx-1'\n            items={displayedMutationTypes}\n            label={mutationTypesSelectorLabel}\n            setItems={(items) => setDisplayedMutationTypes(items)}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nexport const NoDataDisplay: FunctionComponent = () => {\n    return <div>No data available.</div>;\n};\n","import { type FunctionComponent } from 'preact';\nimport { useState } from 'preact/hooks';\nimport { type ChangeEvent } from 'react';\nimport './min-max-percent-slider.css';\n\nexport interface MinMaxPercentSliderProps {\n    min: number;\n    max: number;\n    setMin: (min: number) => void;\n    setMax: (max: number) => void;\n    rangeMin?: number;\n    rangeMax?: number;\n    step?: number;\n}\n\nexport const MinMaxRangeSlider: FunctionComponent<MinMaxPercentSliderProps> = ({\n    min,\n    max,\n    setMin,\n    setMax,\n    rangeMin = 0,\n    rangeMax = 100,\n    step = 0.1,\n}) => {\n    const sliderColor = '#C6C6C6';\n    const rangeColor = '#387bbe';\n\n    const [zIndexTo, setZIndexTo] = useState(0);\n\n    const onMinChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const minValue = Number(input.value);\n\n        if (minValue > max) {\n            setMax(minValue);\n            setMin(minValue);\n        } else {\n            setMin(minValue);\n        }\n    };\n\n    const onMaxChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const maxValue = Number(input.value);\n\n        if (maxValue <= 0) {\n            setZIndexTo(2);\n        } else {\n            setZIndexTo(0);\n        }\n\n        if (maxValue < min) {\n            setMin(maxValue);\n            setMax(maxValue);\n        } else {\n            setMax(maxValue);\n        }\n    };\n\n    const background = `\n        linear-gradient(\n            to right,\n            ${sliderColor} 0%,\n            ${sliderColor} ${min}%,\n            ${rangeColor} ${min}%,\n            ${rangeColor} ${max}%,\n            ${sliderColor} ${max}%,\n            ${sliderColor} 100%)\n    `;\n\n    return (\n        <div class='my-4 relative'>\n            <input\n                id='fromSlider'\n                type='range'\n                value={min}\n                onInput={onMinChange}\n                min={rangeMin}\n                max={rangeMax}\n                step={step}\n                style={{ background, zIndex: 1, height: 0 }}\n            />\n            <input\n                id='toSlider'\n                type='range'\n                value={max}\n                min={rangeMin}\n                max={rangeMax}\n                step={step}\n                onInput={onMaxChange}\n                style={{ background, zIndex: zIndexTo }}\n            />\n        </div>\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useEffect, useState } from 'preact/hooks';\nimport { type ChangeEvent } from 'react';\n\nexport type PercentInputProps = {\n    percentage: number;\n    setPercentage: (percentage: number) => void;\n};\n\nconst percentageInRange = (percentage: number) => {\n    return percentage <= 100 && percentage >= 0;\n};\n\nexport const PercentInput: FunctionComponent<PercentInputProps> = ({ percentage, setPercentage }) => {\n    const [internalPercentage, setInternalPercentage] = useState(percentage);\n\n    useEffect(() => {\n        setInternalPercentage(percentage);\n    }, [percentage]);\n\n    const handleInputChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const value = Number(input.value);\n\n        const inRange = percentageInRange(value);\n\n        if (inRange) {\n            setPercentage(value);\n        }\n        setInternalPercentage(value);\n    };\n\n    const isError = !percentageInRange(internalPercentage);\n    return (\n        <label className={`input input-bordered flex items-center gap-2 w-32 ${isError ? 'input-error' : ''}`}>\n            <input\n                type='number'\n                step={0.1}\n                min={0}\n                max={100}\n                value={internalPercentage}\n                onInput={handleInputChange}\n                lang='en'\n                className={`grow w-16`}\n            />\n            %\n        </label>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { MinMaxRangeSlider } from './min-max-range-slider';\nimport { PercentInput } from './percent-intput';\n\nexport type ProportionInterval = { min: number; max: number };\n\nexport interface ProportionSelectorProps {\n    proportionInterval: ProportionInterval;\n    setMinProportion: (minProportion: number) => void;\n    setMaxProportion: (maxProportion: number) => void;\n}\n\nexport const ProportionSelector: FunctionComponent<ProportionSelectorProps> = ({\n    proportionInterval,\n    setMinProportion,\n    setMaxProportion,\n}) => {\n    const { min: minProportion, max: maxProportion } = proportionInterval;\n    return (\n        <div class='flex flex-col w-64 mb-2'>\n            <div class='flex items-center '>\n                <PercentInput\n                    percentage={minProportion * 100}\n                    setPercentage={(percentage) => setMinProportion(percentage / 100)}\n                />\n                <div class='m-2'>-</div>\n                <PercentInput\n                    percentage={maxProportion * 100}\n                    setPercentage={(percentage) => setMaxProportion(percentage / 100)}\n                />\n            </div>\n            <div class='my-1'>\n                <MinMaxRangeSlider\n                    min={minProportion * 100}\n                    max={maxProportion * 100}\n                    setMin={(percentage) => setMinProportion(percentage / 100)}\n                    setMax={(percentage) => setMaxProportion(percentage / 100)}\n                />\n            </div>\n        </div>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { ProportionSelector, type ProportionSelectorProps } from './proportion-selector';\n\nexport interface ProportionSelectorDropdownProps extends ProportionSelectorProps {\n    openDirection?: 'left' | 'right';\n}\n\nexport const ProportionSelectorDropdown: FunctionComponent<ProportionSelectorDropdownProps> = ({\n    proportionInterval,\n    setMinProportion,\n    setMaxProportion,\n    openDirection = 'right',\n}) => {\n    const label = `${(proportionInterval.min * 100).toFixed(1)}% - ${(proportionInterval.max * 100).toFixed(1)}%`;\n\n    return (\n        <div class={`dropdown ${openDirection === 'left' ? 'dropdown-end' : ''}`}>\n            <div tabIndex={0} role='button' class='btn btn-xs whitespace-nowrap'>\n                Proportion {label}\n            </div>\n            <ul tabIndex={0} class='p-2 shadow menu dropdown-content z-[1] bg-base-100 rounded-box w-72'>\n                <div class='mb-2 ml-2'>\n                    <ProportionSelector\n                        proportionInterval={proportionInterval}\n                        setMinProportion={setMinProportion}\n                        setMaxProportion={setMaxProportion}\n                    />\n                </div>\n            </ul>\n        </div>\n    );\n};\n","import { Fragment, type FunctionComponent } from 'preact';\nimport { useState } from 'preact/hooks';\nimport { type JSXInternal } from 'preact/src/jsx';\n\ntype Tab = {\n    title: string;\n    content: JSXInternal.Element;\n};\n\ninterface ComponentTabsProps {\n    tabs: Tab[];\n    toolbar?: JSXInternal.Element | ((activeTab: string) => JSXInternal.Element);\n}\n\nconst Tabs: FunctionComponent<ComponentTabsProps> = ({ tabs, toolbar }) => {\n    const [activeTab, setActiveTab] = useState(tabs[0].title);\n\n    const tabNames = tabs.map((tab) => tab.title).join(', ');\n\n    const tabElements = tabs.map((tab) => {\n        return (\n            <Fragment key={tab.title}>\n                <input\n                    type='radio'\n                    name={tabNames}\n                    role='tab'\n                    className='tab'\n                    aria-label={tab.title}\n                    checked={activeTab === tab.title}\n                    onChange={() => setActiveTab(tab.title)}\n                />\n                <div role='tabpanel' className='tab-content bg-base-100 border-base-300 rounded-box p-1'>\n                    {tab.content}\n                </div>\n            </Fragment>\n        );\n    });\n\n    const toolbarElement = typeof toolbar === 'function' ? toolbar(activeTab) : toolbar;\n\n    return (\n        <div role='tablist' className='tabs tabs-lifted'>\n            {tabElements}\n            {toolbar && <div className='m-1 col-[9999]'>{toolbarElement}</div>}\n        </div>\n    );\n};\n\nexport default Tabs;\n","import { useEffect, useState } from 'preact/hooks';\n\nexport function useQuery<Data>(fetchDataCallback: () => Promise<Data>, dependencies: unknown[] = []) {\n    const [data, setData] = useState<Data | null>(null);\n    const [error, setError] = useState<Error | null>(null);\n    const [isLoading, setIsLoading] = useState(true);\n\n    useEffect(() => {\n        const fetchData = async () => {\n            setIsLoading(true);\n            try {\n                const result = await fetchDataCallback();\n                setData(result);\n                setError(null);\n            } catch (error) {\n                setError(error as Error);\n            } finally {\n                setIsLoading(false);\n            }\n        };\n\n        fetchData();\n        // eslint-disable-next-line react-hooks/exhaustive-deps\n    }, [JSON.stringify(dependencies)]);\n\n    return { data, error, isLoading };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type Dispatch, type StateUpdater, useContext, useMemo, useState } from 'preact/hooks';\n\nimport { getMutationComparisonTableData } from './getMutationComparisonTableData';\nimport { MutationComparisonTable } from './mutation-comparison-table';\nimport { MutationComparisonVenn } from './mutation-comparison-venn';\nimport { filterMutationData, type MutationData, queryMutationData } from './queryMutationData';\nimport { type LapisFilter, type SequenceType } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { type DisplayedSegment, SegmentSelector, useDisplayedSegments } from '../components/SegmentSelector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { type DisplayedMutationType, MutationTypeSelector } from '../components/mutation-type-selector';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { ProportionSelectorDropdown } from '../components/proportion-selector-dropdown';\nimport Tabs from '../components/tabs';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'table' | 'venn';\n\nexport interface MutationComparisonVariant {\n    lapisFilter: LapisFilter;\n    displayName: string;\n}\n\nexport interface MutationComparisonProps {\n    variants: MutationComparisonVariant[];\n    sequenceType: SequenceType;\n    views: View[];\n}\n\nexport const MutationComparison: FunctionComponent<MutationComparisonProps> = ({ variants, sequenceType, views }) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const { data, error, isLoading } = useQuery(async () => {\n        return queryMutationData(variants, sequenceType, lapis);\n    }, [variants, sequenceType, lapis]);\n\n    const headline = 'Mutation comparison';\n\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <MutationComparisonTabs data={data.mutationData} sequenceType={sequenceType} views={views} />\n        </Headline>\n    );\n};\n\ntype MutationComparisonTabsProps = {\n    data: MutationData[];\n    views: View[];\n    sequenceType: SequenceType;\n};\n\nconst MutationComparisonTabs: FunctionComponent<MutationComparisonTabsProps> = ({ data, views, sequenceType }) => {\n    const [proportionInterval, setProportionInterval] = useState({ min: 0.5, max: 1 });\n    const [displayedMutationTypes, setDisplayedMutationTypes] = useState<DisplayedMutationType[]>([\n        { label: 'Substitutions', checked: true, type: 'substitution' },\n        { label: 'Deletions', checked: true, type: 'deletion' },\n    ]);\n    const [displayedSegments, setDisplayedSegments] = useDisplayedSegments(sequenceType);\n\n    const filteredData = useMemo(\n        () => filterMutationData(data, displayedSegments, displayedMutationTypes),\n        [data, displayedSegments, displayedMutationTypes],\n    );\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'table':\n                return {\n                    title: 'Table',\n                    content: (\n                        <MutationComparisonTable\n                            data={{ content: filteredData }}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n            case 'venn':\n                return {\n                    title: 'Venn',\n                    content: (\n                        <MutationComparisonVenn\n                            data={{ content: filteredData }}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    return (\n        <Tabs\n            tabs={tabs}\n            toolbar={\n                <Toolbar\n                    displayedSegments={displayedSegments}\n                    setDisplayedSegments={setDisplayedSegments}\n                    displayedMutationTypes={displayedMutationTypes}\n                    setDisplayedMutationTypes={setDisplayedMutationTypes}\n                    filteredData={filteredData}\n                    proportionInterval={proportionInterval}\n                    setProportionInterval={setProportionInterval}\n                />\n            }\n        />\n    );\n};\n\ntype ToolbarProps = {\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (segments: DisplayedSegment[]) => void;\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (types: DisplayedMutationType[]) => void;\n    filteredData: MutationData[];\n    proportionInterval: ProportionInterval;\n    setProportionInterval: Dispatch<StateUpdater<ProportionInterval>>;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    displayedSegments,\n    setDisplayedSegments,\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n    filteredData,\n    proportionInterval,\n    setProportionInterval,\n}) => {\n    return (\n        <div class='flex flex-row'>\n            <ProportionSelectorDropdown\n                proportionInterval={proportionInterval}\n                setMinProportion={(min) => setProportionInterval((prev) => ({ ...prev, min }))}\n                setMaxProportion={(max) => setProportionInterval((prev) => ({ ...prev, max }))}\n            />\n            <SegmentSelector displayedSegments={displayedSegments} setDisplayedSegments={setDisplayedSegments} />\n            <MutationTypeSelector\n                displayedMutationTypes={displayedMutationTypes}\n                setDisplayedMutationTypes={setDisplayedMutationTypes}\n            />\n            <CsvDownloadButton\n                className='mx-1 btn btn-xs'\n                getData={() => getMutationComparisonTableData({ content: filteredData }, proportionInterval)}\n                filename='mutation_comparison.csv'\n            />\n            <Info className='mx-1' content='Info for mutation comparison' />\n        </div>\n    );\n};\n","import { consume } from '@lit/context';\nimport { type PropertyValues, ReactiveElement } from '@lit/reactive-element';\nimport { unsafeCSS } from 'lit';\nimport { render } from 'preact';\nimport { type JSXInternal } from 'preact/src/jsx';\n\nimport { lapisContext } from './lapis-context';\nimport { referenceGenomeContext } from './reference-genome-context';\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\nimport { LapisUrlContext } from '../preact/LapisUrlContext';\nimport { ReferenceGenomeContext } from '../preact/ReferenceGenomeContext';\nimport minMaxPercentSliderCss from '../preact/components/min-max-percent-slider.css?inline';\nimport tailwindStyle from '../styles/tailwind.css?inline';\n\nimport '../styles/tailwind.css';\nimport '../preact/components/min-max-percent-slider.css';\n\nconst tailwindElementCss = unsafeCSS(tailwindStyle);\nconst minMaxPercentSliderElementCss = unsafeCSS(minMaxPercentSliderCss);\n\nexport abstract class PreactLitAdapter extends ReactiveElement {\n    static override styles = [tailwindElementCss, minMaxPercentSliderElementCss];\n\n    /**\n     * @internal\n     * The URL of the Lapis instance.\n     *\n     * This component must be a child of a `gs-app` component.\n     * This value will automatically be injected by the parent `gs-app` component.\n     */\n    @consume({ context: lapisContext })\n    lapis: string = '';\n\n    /**\n     * @internal\n     * The reference genomes of the underlying organism.\n     * These will be fetched from the Lapis instance.\n     *\n     * This component must be a child of a `gs-app` component.\n     * This value will automatically be injected by the parent `gs-app` component.\n     */\n    @consume({ context: referenceGenomeContext, subscribe: true })\n    referenceGenome: ReferenceGenome = {\n        nucleotideSequences: [],\n        genes: [],\n    };\n\n    override update(changedProperties: PropertyValues) {\n        console.log('this.lapis', this.lapis);\n        const vdom = (\n            <LapisUrlContext.Provider value={this.lapis}>\n                <ReferenceGenomeContext.Provider value={this.referenceGenome}>\n                    {this.render()}\n                </ReferenceGenomeContext.Provider>\n            </LapisUrlContext.Provider>\n        );\n        super.update(changedProperties);\n        render(vdom, this.renderRoot);\n    }\n\n    protected abstract render(): JSXInternal.Element;\n}\n","import gridJsStyle from 'gridjs/dist/theme/mermaid.css?inline';\nimport { unsafeCSS } from 'lit';\n\nimport { PreactLitAdapter } from './PreactLitAdapter';\n\nimport 'gridjs/dist/theme/mermaid.css';\n\nconst gridJsElementCss = unsafeCSS(gridJsStyle);\n\nexport abstract class PreactLitAdapterWithGridJsStyles extends PreactLitAdapter {\n    static override styles = [...PreactLitAdapter.styles, gridJsElementCss];\n}\n","import { customElement, property } from 'lit/decorators.js';\n\nimport {\n    MutationComparison,\n    type MutationComparisonVariant,\n    type View,\n} from '../../preact/mutationComparison/mutation-comparison';\nimport { type SequenceType } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-mutation-comparison-component')\nexport class MutationComparisonComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Array })\n    variants: MutationComparisonVariant[] = [];\n\n    @property({ type: String })\n    sequenceType: SequenceType = 'nucleotide';\n\n    @property({ type: Array })\n    views: View[] = ['table'];\n\n    override render() {\n        return <MutationComparison variants={this.variants} sequenceType={this.sequenceType} views={this.views} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-mutation-comparison-component': MutationComparisonComponent;\n    }\n}\n","import { type InsertionEntry } from '../../types';\n\nexport function getInsertionsTableData(data: InsertionEntry[]) {\n    return data.map((mutationEntry) => {\n        return {\n            insertion: mutationEntry.mutation.toString(),\n            count: mutationEntry.count,\n        };\n    });\n}\n","import { type SubstitutionOrDeletionEntry } from '../../types';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\nexport function getMutationsTableData(data: SubstitutionOrDeletionEntry[], proportionInterval: ProportionInterval) {\n    const byProportion = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return mutationEntry.proportion >= proportionInterval.min && mutationEntry.proportion <= proportionInterval.max;\n    };\n\n    return data.filter(byProportion).map((mutationEntry) => {\n        return {\n            mutation: mutationEntry.mutation.toString(),\n            type: mutationEntry.type,\n            count: mutationEntry.count,\n            proportion: mutationEntry.proportion,\n        };\n    });\n}\n","const pattern = /(?:([A-Za-z0-9]+):)?(\\d+)$/;\n\nexport const sortMutationPositions = (a: string, b: string) => {\n    const aMatch = a.match(pattern);\n    const bMatch = b.match(pattern);\n\n    if (aMatch && bMatch) {\n        if (aMatch[1] !== bMatch[1]) {\n            return aMatch[1].localeCompare(bMatch[1]);\n        }\n        return parseInt(aMatch[2], 10) - parseInt(bMatch[2], 10);\n    }\n    throw new Error(`Invalid mutation position: ${a} or ${b}`);\n};\n","import { type BaseCell } from './mutations-grid';\nimport type { SequenceType, SubstitutionOrDeletionEntry } from '../../types';\nimport { bases } from '../../utils/mutations';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { sortMutationPositions } from '../shared/sort/sortMutationPositions';\n\nexport const getMutationsGridData = (\n    data: SubstitutionOrDeletionEntry[],\n    sequenceType: SequenceType,\n    proportionInterval: ProportionInterval,\n) => {\n    return accumulateByPosition(data, sequenceType).filter((row) => byProportion(row, proportionInterval));\n};\n\nconst accumulateByPosition = (data: SubstitutionOrDeletionEntry[], sequenceType: SequenceType) => {\n    const basesOfView = bases[sequenceType];\n    const positionsToProportionAtBase = new Map<string, Map<string | undefined, number>>();\n    const referenceBases = new Map<string, string | undefined>();\n\n    for (const mutationEntry of data) {\n        const position =\n            (mutationEntry.mutation.segment ? `${mutationEntry.mutation.segment}:` : '') +\n            mutationEntry.mutation.position;\n        referenceBases.set(position, mutationEntry.mutation.valueAtReference);\n\n        const initiallyFillPositionsToProportionAtBase = () => {\n            if (!positionsToProportionAtBase.has(position)) {\n                const empty = new Map();\n                basesOfView.forEach((base) => empty.set(base, 0));\n                empty.set(mutationEntry.mutation.valueAtReference, 1);\n                positionsToProportionAtBase.set(position, empty);\n            }\n        };\n        initiallyFillPositionsToProportionAtBase();\n\n        const substitutionValue =\n            mutationEntry.type === 'substitution' ? mutationEntry.mutation.substitutionValue : '-';\n\n        const subtractSubstitutionValue = () => {\n            const proportionAtBase = positionsToProportionAtBase.get(position)!;\n            proportionAtBase.set(substitutionValue, mutationEntry.proportion);\n            proportionAtBase.set(\n                mutationEntry.mutation.valueAtReference,\n                proportionAtBase.get(mutationEntry.mutation.valueAtReference)! - mutationEntry.proportion,\n            );\n        };\n        subtractSubstitutionValue();\n    }\n    const orderedPositionsToProportionAtBase = [...positionsToProportionAtBase.entries()]\n        .map(([position, proportionsAtBase]) => ({ position, proportions: proportionsAtBase }))\n        .sort((a, b) => {\n            return sortMutationPositions(a.position, b.position);\n        });\n\n    return orderedPositionsToProportionAtBase.map((proportionsForBaseAtPosition) => {\n        const proportions = bases[sequenceType].map((base) => {\n            return {\n                [base]: {\n                    proportion: proportionsForBaseAtPosition.proportions.get(base)!,\n                    isReference: base === referenceBases.get(proportionsForBaseAtPosition.position),\n                },\n            };\n        });\n\n        return {\n            position: proportionsForBaseAtPosition.position,\n            ...proportions.reduce((acc, curr) => ({ ...acc, ...curr }), {}),\n        } as MutationsGridDataRow;\n    });\n};\n\nexport type BasesData = {\n    [base: string]: BaseCell;\n};\nexport type MutationsGridDataRow = BasesData & { position: string };\n\nconst byProportion = (row: MutationsGridDataRow, proportionInterval: ProportionInterval) => {\n    const numbersAndIsReference = Object.values(row).filter(\n        (\n            cell,\n        ): cell is {\n            proportion: number;\n            isReference: boolean;\n        } => typeof cell === 'object',\n    );\n\n    return numbersAndIsReference.some((cell) => {\n        return (\n            !cell.isReference && cell.proportion >= proportionInterval.min && cell.proportion <= proportionInterval.max\n        );\n    });\n};\n","import { type Row } from 'gridjs';\nimport { type FunctionComponent } from 'preact';\n\nimport { getMutationsGridData } from './getMutationsGridData';\nimport { type SequenceType, type SubstitutionOrDeletionEntry } from '../../types';\nimport { bases } from '../../utils/mutations';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { Table, tableStyle } from '../components/table';\nimport { sortMutationPositions } from '../shared/sort/sortMutationPositions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\ninterface MutationsGridProps {\n    data: SubstitutionOrDeletionEntry[];\n    sequenceType: SequenceType;\n    proportionInterval: ProportionInterval;\n}\n\nexport type BaseCell = {\n    proportion: number;\n    isReference: boolean;\n};\n\nexport const MutationsGrid: FunctionComponent<MutationsGridProps> = ({ data, sequenceType, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Position',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortMutationPositions(a, b);\n                    },\n                },\n            },\n            ...getBasesHeaders(),\n        ];\n    };\n\n    const getBasesHeaders = () => {\n        return bases[sequenceType].map((base) => {\n            return {\n                name: base,\n                sort: {\n                    compare: (a: BaseCell, b: BaseCell) => {\n                        const aProportion = a.proportion;\n                        const bProportion = b.proportion;\n                        if (aProportion < bProportion) {\n                            return -1;\n                        }\n                        if (aProportion > bProportion) {\n                            return 1;\n                        }\n\n                        return 0;\n                    },\n                },\n                formatter: (cell: BaseCell) => formatProportion(cell.proportion),\n                attributes: (cell: BaseCell, row: Row) => {\n                    // grid-js: the cell and row are null for header cells\n                    if (row === null) {\n                        return {};\n                    }\n\n                    return styleCells(cell);\n                },\n            };\n        });\n    };\n\n    const styleCells = (cell: BaseCell) => {\n        if (cell.isReference || cell.proportion < 0.0001) {\n            return {\n                style: {\n                    ...tableStyle.td,\n                    color: 'gray',\n                },\n            };\n        }\n        return {};\n    };\n\n    const tableData = getMutationsGridData(data, sequenceType, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { Insertion } from '../../../utils/mutations';\n\nexport const sortInsertions = (a: string, b: string) => {\n    const insertionA = Insertion.parse(a);\n    const insertionB = Insertion.parse(b);\n\n    if (insertionA && insertionB) {\n        const segmentA = insertionA.segment;\n        const segmentB = insertionB.segment;\n        if (segmentA !== undefined && segmentB !== undefined && segmentA !== segmentB) {\n            return segmentA.localeCompare(segmentB);\n        }\n        const positionA = insertionA.position;\n        const positionB = insertionB.position;\n        if (positionA !== positionB) {\n            return positionA - positionB;\n        }\n        return insertionA.insertedSymbols.localeCompare(insertionB.insertedSymbols);\n    }\n    throw new Error(`Invalid insertion: ${a} or ${b}`);\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getInsertionsTableData } from './getInsertionsTableData';\nimport { type InsertionEntry } from '../../types';\nimport { Table } from '../components/table';\nimport { sortInsertions } from '../shared/sort/sortInsertions';\n\nexport interface InsertionsTableProps {\n    data: InsertionEntry[];\n}\n\nexport const InsertionsTable: FunctionComponent<InsertionsTableProps> = ({ data }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Insertion',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortInsertions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Count',\n                sort: true,\n            },\n        ];\n    };\n\n    const tableData = getInsertionsTableData(data).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getMutationsTableData } from './getMutationsTableData';\nimport { type SubstitutionOrDeletionEntry } from '../../types';\nimport type { ProportionInterval } from '../components/proportion-selector';\nimport { Table } from '../components/table';\nimport { sortSubstitutionsAndDeletions } from '../shared/sort/sortSubstitutionsAndDeletions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\nexport interface MutationsTableProps {\n    data: SubstitutionOrDeletionEntry[];\n    proportionInterval: ProportionInterval;\n}\n\nconst MutationsTable: FunctionComponent<MutationsTableProps> = ({ data, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Mutation',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortSubstitutionsAndDeletions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Type',\n                sort: true,\n            },\n            {\n                name: 'Count',\n                sort: true,\n            },\n            {\n                name: 'Proportion',\n                sort: true,\n                formatter: (cell: number) => formatProportion(cell),\n            },\n        ];\n    };\n\n    const tableData = getMutationsTableData(data, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n\nexport default MutationsTable;\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchInsertions } from '../lapisApi/lapisApi';\nimport { type InsertionEntry, type LapisFilter, type SequenceType } from '../types';\nimport { Insertion } from '../utils/mutations';\n\nexport class FetchInsertionsOperator implements Operator<InsertionEntry> {\n    constructor(\n        private filter: LapisFilter,\n        private sequenceType: SequenceType,\n    ) {}\n\n    async evaluate(lapisUrl: string, signal?: AbortSignal): Promise<Dataset<InsertionEntry>> {\n        const insertions = (await fetchInsertions(lapisUrl, this.filter, this.sequenceType, signal)).data;\n\n        const content: InsertionEntry[] = insertions.map(({ count, insertedSymbols, sequenceName, position }) => ({\n            type: 'insertion',\n            mutation: new Insertion(sequenceName ?? undefined, position, insertedSymbols),\n            count,\n        }));\n\n        return { content };\n    }\n}\n","import { FetchInsertionsOperator } from '../operator/FetchInsertionsOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type SequenceType } from '../types';\n\nexport function queryInsertions(variant: LapisFilter, sequenceType: SequenceType, lapis: string, signal?: AbortSignal) {\n    const fetchData = new FetchInsertionsOperator(variant, sequenceType);\n    const sortData = new SortOperator(fetchData, (a, b) => {\n        if (a.mutation.segment !== b.mutation.segment) {\n            return (a.mutation.segment ?? '').localeCompare(b.mutation.segment ?? '');\n        }\n        return a.mutation.position - b.mutation.position;\n    });\n    return sortData.evaluate(lapis, signal);\n}\n","import { queryInsertions } from '../../query/queryInsertions';\nimport { querySubstitutionsOrDeletions } from '../../query/querySubstitutionsOrDeletions';\nimport {\n    type InsertionEntry,\n    type LapisFilter,\n    type MutationEntry,\n    type SubstitutionOrDeletionEntry,\n} from '../../types';\nimport { type DisplayedSegment } from '../components/SegmentSelector';\nimport { type DisplayedMutationType } from '../components/mutation-type-selector';\n\nexport async function queryMutationsData(\n    variant: LapisFilter,\n    sequenceType: 'nucleotide' | 'amino acid',\n    lapis: string,\n) {\n    const substitutionsOrDeletions = (await querySubstitutionsOrDeletions(variant, sequenceType, lapis)).content;\n    const insertions = (await queryInsertions(variant, sequenceType, lapis)).content;\n\n    return {\n        substitutionsOrDeletions,\n        insertions,\n    };\n}\n\nexport function filterMutationsData(\n    data: { insertions: InsertionEntry[]; substitutionsOrDeletions: SubstitutionOrDeletionEntry[] },\n    displayedSegments: DisplayedSegment[],\n    displayedMutationTypes: DisplayedMutationType[],\n) {\n    function bySelectedSegments(mutationEntry: MutationEntry) {\n        if (mutationEntry.mutation.segment === undefined) {\n            return true;\n        }\n        return displayedSegments.some(\n            (displayedSegment) =>\n                displayedSegment.segment === mutationEntry.mutation.segment && displayedSegment.checked,\n        );\n    }\n\n    const byDisplayedMutationTypes = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return displayedMutationTypes.some(\n            (displayedMutationType) =>\n                displayedMutationType.checked && displayedMutationType.type === mutationEntry.type,\n        );\n    };\n\n    const filteredSubstitutionsOrDeletions = data.substitutionsOrDeletions.filter(bySelectedSegments);\n\n    return {\n        insertions: data.insertions.filter(bySelectedSegments),\n        tableData: filteredSubstitutionsOrDeletions.filter(byDisplayedMutationTypes),\n        gridData: filteredSubstitutionsOrDeletions,\n    };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type Dispatch, type StateUpdater, useContext, useState } from 'preact/hooks';\n\nimport { getInsertionsTableData } from './getInsertionsTableData';\nimport { getMutationsTableData } from './getMutationsTableData';\nimport { MutationsGrid } from './mutations-grid';\nimport { InsertionsTable } from './mutations-insertions-table';\nimport MutationsTable from './mutations-table';\nimport { filterMutationsData, queryMutationsData } from './queryMutations';\nimport {\n    type InsertionEntry,\n    type LapisFilter,\n    type SequenceType,\n    type SubstitutionOrDeletionEntry,\n} from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { type DisplayedSegment, SegmentSelector, useDisplayedSegments } from '../components/SegmentSelector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { type DisplayedMutationType, MutationTypeSelector } from '../components/mutation-type-selector';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport type { ProportionInterval } from '../components/proportion-selector';\nimport { ProportionSelectorDropdown } from '../components/proportion-selector-dropdown';\nimport Tabs from '../components/tabs';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'table' | 'grid' | 'insertions';\n\nexport interface MutationsProps {\n    variant: LapisFilter;\n    sequenceType: SequenceType;\n    views: View[];\n}\n\nexport const Mutations: FunctionComponent<MutationsProps> = ({ variant, sequenceType, views }) => {\n    const lapis = useContext(LapisUrlContext);\n    const { data, error, isLoading } = useQuery(async () => {\n        return queryMutationsData(variant, sequenceType, lapis);\n    }, [variant, sequenceType, lapis]);\n\n    const headline = 'Mutations';\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <MutationsTabs mutationsData={data} sequenceType={sequenceType} views={views} />\n        </Headline>\n    );\n};\n\ntype MutationTabsProps = {\n    mutationsData: { insertions: InsertionEntry[]; substitutionsOrDeletions: SubstitutionOrDeletionEntry[] };\n    sequenceType: SequenceType;\n    views: View[];\n};\n\nconst MutationsTabs: FunctionComponent<MutationTabsProps> = ({ mutationsData, sequenceType, views }) => {\n    const [proportionInterval, setProportionInterval] = useState({ min: 0.05, max: 1 });\n\n    const [displayedSegments, setDisplayedSegments] = useDisplayedSegments(sequenceType);\n    const [displayedMutationTypes, setDisplayedMutationTypes] = useState<DisplayedMutationType[]>([\n        { label: 'Substitutions', checked: true, type: 'substitution' },\n        { label: 'Deletions', checked: true, type: 'deletion' },\n    ]);\n\n    const filteredData = filterMutationsData(mutationsData, displayedSegments, displayedMutationTypes);\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'table':\n                return {\n                    title: 'Table',\n                    content: <MutationsTable data={filteredData.tableData} proportionInterval={proportionInterval} />,\n                };\n            case 'grid':\n                return {\n                    title: 'Grid',\n                    content: (\n                        <MutationsGrid\n                            data={filteredData.gridData}\n                            sequenceType={sequenceType}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n            case 'insertions':\n                return {\n                    title: 'Insertions',\n                    content: <InsertionsTable data={filteredData.insertions} />,\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    const toolbar = (activeTab: string) => (\n        <Toolbar\n            activeTab={activeTab}\n            displayedSegments={displayedSegments}\n            setDisplayedSegments={setDisplayedSegments}\n            displayedMutationTypes={displayedMutationTypes}\n            setDisplayedMutationTypes={setDisplayedMutationTypes}\n            filteredData={filteredData}\n            proportionInterval={proportionInterval}\n            setProportionInterval={setProportionInterval}\n        />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype ToolbarProps = {\n    activeTab: string;\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (segments: DisplayedSegment[]) => void;\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (types: DisplayedMutationType[]) => void;\n    filteredData: { tableData: SubstitutionOrDeletionEntry[]; insertions: InsertionEntry[] };\n    proportionInterval: ProportionInterval;\n    setProportionInterval: Dispatch<StateUpdater<ProportionInterval>>;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    activeTab,\n    displayedSegments,\n    setDisplayedSegments,\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n    filteredData,\n    proportionInterval,\n    setProportionInterval,\n}) => {\n    return (\n        <div class='flex flex-row'>\n            <SegmentSelector displayedSegments={displayedSegments} setDisplayedSegments={setDisplayedSegments} />\n            {activeTab === 'Table' && (\n                <MutationTypeSelector\n                    setDisplayedMutationTypes={setDisplayedMutationTypes}\n                    displayedMutationTypes={displayedMutationTypes}\n                />\n            )}\n            {(activeTab === 'Table' || activeTab === 'Grid') && (\n                <>\n                    <ProportionSelectorDropdown\n                        proportionInterval={proportionInterval}\n                        setMinProportion={(min) => setProportionInterval((prev) => ({ ...prev, min }))}\n                        setMaxProportion={(max) => setProportionInterval((prev) => ({ ...prev, max }))}\n                        openDirection={'left'}\n                    />\n                    <CsvDownloadButton\n                        className='mx-1 btn btn-xs'\n                        getData={() => getMutationsTableData(filteredData.tableData, proportionInterval)}\n                        filename='substitutionsAndDeletions.csv'\n                    />\n                </>\n            )}\n            {activeTab === 'Insertions' && (\n                <CsvDownloadButton\n                    className='mx-1 btn btn-xs'\n                    getData={() => getInsertionsTableData(filteredData.insertions)}\n                    filename='insertions.csv'\n                />\n            )}\n            <Info className='mx-1' content='Info for mutations' />\n        </div>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { Mutations, type View } from '../../preact/mutations/mutations';\nimport { type LapisFilter, type SequenceType } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-mutations-component')\nexport class MutationsComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Object })\n    variant: LapisFilter = { displayName: '' };\n\n    @property({ type: String })\n    sequenceType: SequenceType = 'nucleotide';\n\n    @property({ type: Array })\n    views: View[] = ['table', 'grid'];\n\n    override render() {\n        return <Mutations variant={this.variant} sequenceType={this.sequenceType} views={this.views} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-mutations-component': MutationsComponent;\n    }\n}\n","import { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { type TemporalGranularity } from '../../types';\n\nexport function getPrevalenceOverTimeTableData(data: PrevalenceOverTimeData, granularity: TemporalGranularity) {\n    return data[0].content.map((row, rowNumber) => {\n        const otherColumns = data\n            .map((dataset) => ({\n                [`${dataset.displayName} prevalence`]: dataset.content[rowNumber].prevalence.toFixed(4),\n                [`${dataset.displayName} count`]: dataset.content[rowNumber].count,\n            }))\n            .reduce((acc, val) => ({ ...acc, ...val }), {});\n\n        return {\n            [granularity]: row.dateRange?.toString() ?? 'Unknown',\n            ...otherColumns,\n        };\n    });\n}\n","import { type Chart, type CoreScaleOptions, Scale } from 'chart.js';\n\nexport class LogitScale extends Scale {\n    static id = 'logit';\n\n    constructor(cfg: { id: string; type: string; ctx: CanvasRenderingContext2D; chart: Chart }) {\n        super(cfg);\n        this.min = 0.001;\n        this.max = 0.999;\n    }\n\n    override buildTicks() {\n        const tickValues = [this.min, 0.01, 0.1, 0.5, 0.9, 0.99, this.max];\n\n        this.ticks = tickValues.map((value) => ({ value }));\n        return this.ticks;\n    }\n\n    getLogit(value: number): number {\n        if (value <= 0) {\n            return -Infinity;\n        }\n        if (value >= 1) {\n            return Infinity;\n        }\n\n        return Math.log(value / (1 - value));\n    }\n\n    override getPixelForValue(value: number): number {\n        const logitMin = this.getLogit(this.min);\n        const logitMax = this.getLogit(this.max);\n\n        const logitValue = this.getLogit(value);\n\n        const decimal = (logitValue - logitMin) / (logitMax - logitMin);\n\n        return this.getPixelForDecimal(decimal);\n    }\n}\n\ndeclare module 'chart.js' {\n    export interface CartesianScaleTypeRegistry {\n        logit: {\n            options: CoreScaleOptions;\n        };\n    }\n}\n","// colorblind friendly colors taken from https://personal.sron.nl/~pault/\n\nconst ColorsRGB = {\n    indigo: [51, 34, 136],\n    green: [17, 119, 51],\n    cyan: [136, 204, 238],\n    teal: [68, 170, 153],\n    olive: [153, 153, 51],\n    sand: [221, 204, 119],\n    rose: [204, 102, 119],\n    wine: [136, 34, 85],\n    purple: [170, 68, 153],\n};\n\ntype GraphColor = keyof typeof ColorsRGB;\n\nexport const singleGraphColorRGBAById = (id: number, alpha = 1) => {\n    const keys = Object.keys(ColorsRGB) as GraphColor[];\n    const key = keys[id % keys.length];\n\n    return `rgba(${ColorsRGB[key].join(',')},${alpha})`;\n};\n\nexport const singleGraphColorRGBByName = (name: GraphColor, alpha = 1) => {\n    return `rgba(${ColorsRGB[name].join(',')},${alpha})`;\n};\n","// calculateWilsonInterval calculates the Wilson score interval for 95% confidence.\n//\n// This function is based on https://github.com/erikfox/wilson-interval, but without\n// high precision math.\n//\n// observed - number of observed positive outcomes\n// sample - number of experiments or size of the sample\nexport function wilson95PercentConfidenceInterval(observed: number, sample: number) {\n    const p = observed / sample;\n    const n = sample;\n    const z = 1.9599639715843482;\n\n    const numerator = p + (z * z) / (2 * n);\n    const w_plus_minus = z * Math.sqrt((p * (1 - p)) / n + (z * z) / (4 * (n * n)));\n    const denominator = 1 + (z * z) / n;\n\n    return {\n        lowerLimit: (numerator - w_plus_minus) / denominator,\n        upperLimit: (numerator + w_plus_minus) / denominator,\n    };\n}\n\nexport const confidenceIntervalDataLabel = (value: number, lowerLimit: number, upperLimit: number, prefix?: string) => {\n    const label = prefix ? `${prefix}: ` : '';\n\n    return `${label}${value.toFixed(3)} (${lowerLimit.toFixed(3)} - ${upperLimit.toFixed(3)})`;\n};\n\nexport type ConfidenceIntervalMethod = 'wilson' | 'none';\n","export type ScaleType = 'linear' | 'logarithmic' | 'logit';\n\nexport function getYAxisScale(scaleType: ScaleType) {\n    switch (scaleType) {\n        case 'linear': {\n            return { beginAtZero: true, type: 'linear' as const, min: 0, max: 1 };\n        }\n        case 'logarithmic': {\n            return { type: 'logarithmic' as const };\n        }\n        case 'logit':\n            return { type: 'logit' as const };\n        default:\n            return { beginAtZero: true, type: 'linear' as const };\n    }\n}\n","import { Chart, type ChartConfiguration, registerables, type TooltipItem } from 'chart.js';\nimport { BarWithErrorBar, BarWithErrorBarsController } from 'chartjs-chart-error-bars';\n\nimport { type PrevalenceOverTimeData, type PrevalenceOverTimeVariantData } from '../../query/queryPrevalenceOverTime';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport { type ConfidenceIntervalMethod, wilson95PercentConfidenceInterval } from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeBarChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n}\n\nChart.register(...registerables, LogitScale, BarWithErrorBarsController, BarWithErrorBar);\n\nconst PrevalenceOverTimeBarChart = ({\n    data,\n    yAxisScaleType,\n    confidenceIntervalMethod,\n}: PrevalenceOverTimeBarChartProps) => {\n    const config: ChartConfiguration = {\n        type: BarWithErrorBarsController.id,\n        data: {\n            labels: data[0]?.content.map((dateRange) => dateRange.dateRange?.toString() ?? 'Unknown') || [],\n            datasets: data.map((graphData, index) => datasets(graphData, index, confidenceIntervalMethod)),\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(confidenceIntervalMethod),\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nconst datasets = (\n    prevalenceOverTimeVariant: PrevalenceOverTimeVariantData,\n    index: number,\n    confidenceIntervalMethod: ConfidenceIntervalMethod,\n) => {\n    const generalConfig = {\n        borderWidth: 1,\n        pointRadius: 0,\n        label: prevalenceOverTimeVariant.displayName,\n        backgroundColor: singleGraphColorRGBAById(index, 0.3),\n        borderColor: singleGraphColorRGBAById(index),\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                data: prevalenceOverTimeVariant.content.map((dataPoint) => ({\n                    y: dataPoint.prevalence,\n                    yMin: wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).lowerLimit,\n                    yMax: wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).upperLimit,\n                })),\n            };\n        default:\n            return {\n                ...generalConfig,\n                data: prevalenceOverTimeVariant.content.map((dataPoint) => dataPoint.prevalence),\n            };\n    }\n};\n\nconst tooltip = (confidenceIntervalMethod: ConfidenceIntervalMethod) => {\n    const generalConfig = {\n        mode: 'index' as const,\n        intersect: false,\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                callbacks: {\n                    label: (context: TooltipItem<'barWithErrorBars'>) => {\n                        const value = context.dataset.data[context.dataIndex] as {\n                            y: number;\n                            yMin: number;\n                            yMax: number;\n                        };\n\n                        return `${context.dataset.label}: ${value.y.toFixed(3)} (${value.yMin.toFixed(3)} - ${value.yMax.toFixed(3)})`;\n                    },\n                },\n            };\n        default:\n            return generalConfig;\n    }\n};\n\nexport default PrevalenceOverTimeBarChart;\n","export var SECONDS_A_MINUTE = 60;\nexport var SECONDS_A_HOUR = SECONDS_A_MINUTE * 60;\nexport var SECONDS_A_DAY = SECONDS_A_HOUR * 24;\nexport var SECONDS_A_WEEK = SECONDS_A_DAY * 7;\nexport var MILLISECONDS_A_SECOND = 1e3;\nexport var MILLISECONDS_A_MINUTE = SECONDS_A_MINUTE * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_HOUR = SECONDS_A_HOUR * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_DAY = SECONDS_A_DAY * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_WEEK = SECONDS_A_WEEK * MILLISECONDS_A_SECOND; // English locales\n\nexport var MS = 'millisecond';\nexport var S = 'second';\nexport var MIN = 'minute';\nexport var H = 'hour';\nexport var D = 'day';\nexport var W = 'week';\nexport var M = 'month';\nexport var Q = 'quarter';\nexport var Y = 'year';\nexport var DATE = 'date';\nexport var FORMAT_DEFAULT = 'YYYY-MM-DDTHH:mm:ssZ';\nexport var INVALID_DATE_STRING = 'Invalid Date'; // regex\n\nexport var REGEX_PARSE = /^(\\d{4})[-/]?(\\d{1,2})?[-/]?(\\d{0,2})[Tt\\s]*(\\d{1,2})?:?(\\d{1,2})?:?(\\d{1,2})?[.:]?(\\d+)?$/;\nexport var REGEX_FORMAT = /\\[([^\\]]+)]|Y{1,4}|M{1,4}|D{1,2}|d{1,4}|H{1,2}|h{1,2}|a|A|m{1,2}|s{1,2}|Z{1,2}|SSS/g;","// English [en]\n// We don't need weekdaysShort, weekdaysMin, monthsShort in en.js locale\nexport default {\n  name: 'en',\n  weekdays: 'Sunday_Monday_Tuesday_Wednesday_Thursday_Friday_Saturday'.split('_'),\n  months: 'January_February_March_April_May_June_July_August_September_October_November_December'.split('_'),\n  ordinal: function ordinal(n) {\n    var s = ['th', 'st', 'nd', 'rd'];\n    var v = n % 100;\n    return \"[\" + n + (s[(v - 20) % 10] || s[v] || s[0]) + \"]\";\n  }\n};","import * as C from './constant';\n\nvar padStart = function padStart(string, length, pad) {\n  var s = String(string);\n  if (!s || s.length >= length) return string;\n  return \"\" + Array(length + 1 - s.length).join(pad) + string;\n};\n\nvar padZoneStr = function padZoneStr(instance) {\n  var negMinutes = -instance.utcOffset();\n  var minutes = Math.abs(negMinutes);\n  var hourOffset = Math.floor(minutes / 60);\n  var minuteOffset = minutes % 60;\n  return \"\" + (negMinutes <= 0 ? '+' : '-') + padStart(hourOffset, 2, '0') + \":\" + padStart(minuteOffset, 2, '0');\n};\n\nvar monthDiff = function monthDiff(a, b) {\n  // function from moment.js in order to keep the same result\n  if (a.date() < b.date()) return -monthDiff(b, a);\n  var wholeMonthDiff = (b.year() - a.year()) * 12 + (b.month() - a.month());\n  var anchor = a.clone().add(wholeMonthDiff, C.M);\n  var c = b - anchor < 0;\n  var anchor2 = a.clone().add(wholeMonthDiff + (c ? -1 : 1), C.M);\n  return +(-(wholeMonthDiff + (b - anchor) / (c ? anchor - anchor2 : anchor2 - anchor)) || 0);\n};\n\nvar absFloor = function absFloor(n) {\n  return n < 0 ? Math.ceil(n) || 0 : Math.floor(n);\n};\n\nvar prettyUnit = function prettyUnit(u) {\n  var special = {\n    M: C.M,\n    y: C.Y,\n    w: C.W,\n    d: C.D,\n    D: C.DATE,\n    h: C.H,\n    m: C.MIN,\n    s: C.S,\n    ms: C.MS,\n    Q: C.Q\n  };\n  return special[u] || String(u || '').toLowerCase().replace(/s$/, '');\n};\n\nvar isUndefined = function isUndefined(s) {\n  return s === undefined;\n};\n\nexport default {\n  s: padStart,\n  z: padZoneStr,\n  m: monthDiff,\n  a: absFloor,\n  p: prettyUnit,\n  u: isUndefined\n};","import * as C from './constant';\nimport en from './locale/en';\nimport U from './utils';\nvar L = 'en'; // global locale\n\nvar Ls = {}; // global loaded locale\n\nLs[L] = en;\nvar IS_DAYJS = '$isDayjsObject'; // eslint-disable-next-line no-use-before-define\n\nvar isDayjs = function isDayjs(d) {\n  return d instanceof Dayjs || !!(d && d[IS_DAYJS]);\n};\n\nvar parseLocale = function parseLocale(preset, object, isLocal) {\n  var l;\n  if (!preset) return L;\n\n  if (typeof preset === 'string') {\n    var presetLower = preset.toLowerCase();\n\n    if (Ls[presetLower]) {\n      l = presetLower;\n    }\n\n    if (object) {\n      Ls[presetLower] = object;\n      l = presetLower;\n    }\n\n    var presetSplit = preset.split('-');\n\n    if (!l && presetSplit.length > 1) {\n      return parseLocale(presetSplit[0]);\n    }\n  } else {\n    var name = preset.name;\n    Ls[name] = preset;\n    l = name;\n  }\n\n  if (!isLocal && l) L = l;\n  return l || !isLocal && L;\n};\n\nvar dayjs = function dayjs(date, c) {\n  if (isDayjs(date)) {\n    return date.clone();\n  } // eslint-disable-next-line no-nested-ternary\n\n\n  var cfg = typeof c === 'object' ? c : {};\n  cfg.date = date;\n  cfg.args = arguments; // eslint-disable-line prefer-rest-params\n\n  return new Dayjs(cfg); // eslint-disable-line no-use-before-define\n};\n\nvar wrapper = function wrapper(date, instance) {\n  return dayjs(date, {\n    locale: instance.$L,\n    utc: instance.$u,\n    x: instance.$x,\n    $offset: instance.$offset // todo: refactor; do not use this.$offset in you code\n\n  });\n};\n\nvar Utils = U; // for plugin use\n\nUtils.l = parseLocale;\nUtils.i = isDayjs;\nUtils.w = wrapper;\n\nvar parseDate = function parseDate(cfg) {\n  var date = cfg.date,\n      utc = cfg.utc;\n  if (date === null) return new Date(NaN); // null is invalid\n\n  if (Utils.u(date)) return new Date(); // today\n\n  if (date instanceof Date) return new Date(date);\n\n  if (typeof date === 'string' && !/Z$/i.test(date)) {\n    var d = date.match(C.REGEX_PARSE);\n\n    if (d) {\n      var m = d[2] - 1 || 0;\n      var ms = (d[7] || '0').substring(0, 3);\n\n      if (utc) {\n        return new Date(Date.UTC(d[1], m, d[3] || 1, d[4] || 0, d[5] || 0, d[6] || 0, ms));\n      }\n\n      return new Date(d[1], m, d[3] || 1, d[4] || 0, d[5] || 0, d[6] || 0, ms);\n    }\n  }\n\n  return new Date(date); // everything else\n};\n\nvar Dayjs = /*#__PURE__*/function () {\n  function Dayjs(cfg) {\n    this.$L = parseLocale(cfg.locale, null, true);\n    this.parse(cfg); // for plugin\n\n    this.$x = this.$x || cfg.x || {};\n    this[IS_DAYJS] = true;\n  }\n\n  var _proto = Dayjs.prototype;\n\n  _proto.parse = function parse(cfg) {\n    this.$d = parseDate(cfg);\n    this.init();\n  };\n\n  _proto.init = function init() {\n    var $d = this.$d;\n    this.$y = $d.getFullYear();\n    this.$M = $d.getMonth();\n    this.$D = $d.getDate();\n    this.$W = $d.getDay();\n    this.$H = $d.getHours();\n    this.$m = $d.getMinutes();\n    this.$s = $d.getSeconds();\n    this.$ms = $d.getMilliseconds();\n  } // eslint-disable-next-line class-methods-use-this\n  ;\n\n  _proto.$utils = function $utils() {\n    return Utils;\n  };\n\n  _proto.isValid = function isValid() {\n    return !(this.$d.toString() === C.INVALID_DATE_STRING);\n  };\n\n  _proto.isSame = function isSame(that, units) {\n    var other = dayjs(that);\n    return this.startOf(units) <= other && other <= this.endOf(units);\n  };\n\n  _proto.isAfter = function isAfter(that, units) {\n    return dayjs(that) < this.startOf(units);\n  };\n\n  _proto.isBefore = function isBefore(that, units) {\n    return this.endOf(units) < dayjs(that);\n  };\n\n  _proto.$g = function $g(input, get, set) {\n    if (Utils.u(input)) return this[get];\n    return this.set(set, input);\n  };\n\n  _proto.unix = function unix() {\n    return Math.floor(this.valueOf() / 1000);\n  };\n\n  _proto.valueOf = function valueOf() {\n    // timezone(hour) * 60 * 60 * 1000 => ms\n    return this.$d.getTime();\n  };\n\n  _proto.startOf = function startOf(units, _startOf) {\n    var _this = this;\n\n    // startOf -> endOf\n    var isStartOf = !Utils.u(_startOf) ? _startOf : true;\n    var unit = Utils.p(units);\n\n    var instanceFactory = function instanceFactory(d, m) {\n      var ins = Utils.w(_this.$u ? Date.UTC(_this.$y, m, d) : new Date(_this.$y, m, d), _this);\n      return isStartOf ? ins : ins.endOf(C.D);\n    };\n\n    var instanceFactorySet = function instanceFactorySet(method, slice) {\n      var argumentStart = [0, 0, 0, 0];\n      var argumentEnd = [23, 59, 59, 999];\n      return Utils.w(_this.toDate()[method].apply( // eslint-disable-line prefer-spread\n      _this.toDate('s'), (isStartOf ? argumentStart : argumentEnd).slice(slice)), _this);\n    };\n\n    var $W = this.$W,\n        $M = this.$M,\n        $D = this.$D;\n    var utcPad = \"set\" + (this.$u ? 'UTC' : '');\n\n    switch (unit) {\n      case C.Y:\n        return isStartOf ? instanceFactory(1, 0) : instanceFactory(31, 11);\n\n      case C.M:\n        return isStartOf ? instanceFactory(1, $M) : instanceFactory(0, $M + 1);\n\n      case C.W:\n        {\n          var weekStart = this.$locale().weekStart || 0;\n          var gap = ($W < weekStart ? $W + 7 : $W) - weekStart;\n          return instanceFactory(isStartOf ? $D - gap : $D + (6 - gap), $M);\n        }\n\n      case C.D:\n      case C.DATE:\n        return instanceFactorySet(utcPad + \"Hours\", 0);\n\n      case C.H:\n        return instanceFactorySet(utcPad + \"Minutes\", 1);\n\n      case C.MIN:\n        return instanceFactorySet(utcPad + \"Seconds\", 2);\n\n      case C.S:\n        return instanceFactorySet(utcPad + \"Milliseconds\", 3);\n\n      default:\n        return this.clone();\n    }\n  };\n\n  _proto.endOf = function endOf(arg) {\n    return this.startOf(arg, false);\n  };\n\n  _proto.$set = function $set(units, _int) {\n    var _C$D$C$DATE$C$M$C$Y$C;\n\n    // private set\n    var unit = Utils.p(units);\n    var utcPad = \"set\" + (this.$u ? 'UTC' : '');\n    var name = (_C$D$C$DATE$C$M$C$Y$C = {}, _C$D$C$DATE$C$M$C$Y$C[C.D] = utcPad + \"Date\", _C$D$C$DATE$C$M$C$Y$C[C.DATE] = utcPad + \"Date\", _C$D$C$DATE$C$M$C$Y$C[C.M] = utcPad + \"Month\", _C$D$C$DATE$C$M$C$Y$C[C.Y] = utcPad + \"FullYear\", _C$D$C$DATE$C$M$C$Y$C[C.H] = utcPad + \"Hours\", _C$D$C$DATE$C$M$C$Y$C[C.MIN] = utcPad + \"Minutes\", _C$D$C$DATE$C$M$C$Y$C[C.S] = utcPad + \"Seconds\", _C$D$C$DATE$C$M$C$Y$C[C.MS] = utcPad + \"Milliseconds\", _C$D$C$DATE$C$M$C$Y$C)[unit];\n    var arg = unit === C.D ? this.$D + (_int - this.$W) : _int;\n\n    if (unit === C.M || unit === C.Y) {\n      // clone is for badMutable plugin\n      var date = this.clone().set(C.DATE, 1);\n      date.$d[name](arg);\n      date.init();\n      this.$d = date.set(C.DATE, Math.min(this.$D, date.daysInMonth())).$d;\n    } else if (name) this.$d[name](arg);\n\n    this.init();\n    return this;\n  };\n\n  _proto.set = function set(string, _int2) {\n    return this.clone().$set(string, _int2);\n  };\n\n  _proto.get = function get(unit) {\n    return this[Utils.p(unit)]();\n  };\n\n  _proto.add = function add(number, units) {\n    var _this2 = this,\n        _C$MIN$C$H$C$S$unit;\n\n    number = Number(number); // eslint-disable-line no-param-reassign\n\n    var unit = Utils.p(units);\n\n    var instanceFactorySet = function instanceFactorySet(n) {\n      var d = dayjs(_this2);\n      return Utils.w(d.date(d.date() + Math.round(n * number)), _this2);\n    };\n\n    if (unit === C.M) {\n      return this.set(C.M, this.$M + number);\n    }\n\n    if (unit === C.Y) {\n      return this.set(C.Y, this.$y + number);\n    }\n\n    if (unit === C.D) {\n      return instanceFactorySet(1);\n    }\n\n    if (unit === C.W) {\n      return instanceFactorySet(7);\n    }\n\n    var step = (_C$MIN$C$H$C$S$unit = {}, _C$MIN$C$H$C$S$unit[C.MIN] = C.MILLISECONDS_A_MINUTE, _C$MIN$C$H$C$S$unit[C.H] = C.MILLISECONDS_A_HOUR, _C$MIN$C$H$C$S$unit[C.S] = C.MILLISECONDS_A_SECOND, _C$MIN$C$H$C$S$unit)[unit] || 1; // ms\n\n    var nextTimeStamp = this.$d.getTime() + number * step;\n    return Utils.w(nextTimeStamp, this);\n  };\n\n  _proto.subtract = function subtract(number, string) {\n    return this.add(number * -1, string);\n  };\n\n  _proto.format = function format(formatStr) {\n    var _this3 = this;\n\n    var locale = this.$locale();\n    if (!this.isValid()) return locale.invalidDate || C.INVALID_DATE_STRING;\n    var str = formatStr || C.FORMAT_DEFAULT;\n    var zoneStr = Utils.z(this);\n    var $H = this.$H,\n        $m = this.$m,\n        $M = this.$M;\n    var weekdays = locale.weekdays,\n        months = locale.months,\n        meridiem = locale.meridiem;\n\n    var getShort = function getShort(arr, index, full, length) {\n      return arr && (arr[index] || arr(_this3, str)) || full[index].slice(0, length);\n    };\n\n    var get$H = function get$H(num) {\n      return Utils.s($H % 12 || 12, num, '0');\n    };\n\n    var meridiemFunc = meridiem || function (hour, minute, isLowercase) {\n      var m = hour < 12 ? 'AM' : 'PM';\n      return isLowercase ? m.toLowerCase() : m;\n    };\n\n    var matches = function matches(match) {\n      switch (match) {\n        case 'YY':\n          return String(_this3.$y).slice(-2);\n\n        case 'YYYY':\n          return Utils.s(_this3.$y, 4, '0');\n\n        case 'M':\n          return $M + 1;\n\n        case 'MM':\n          return Utils.s($M + 1, 2, '0');\n\n        case 'MMM':\n          return getShort(locale.monthsShort, $M, months, 3);\n\n        case 'MMMM':\n          return getShort(months, $M);\n\n        case 'D':\n          return _this3.$D;\n\n        case 'DD':\n          return Utils.s(_this3.$D, 2, '0');\n\n        case 'd':\n          return String(_this3.$W);\n\n        case 'dd':\n          return getShort(locale.weekdaysMin, _this3.$W, weekdays, 2);\n\n        case 'ddd':\n          return getShort(locale.weekdaysShort, _this3.$W, weekdays, 3);\n\n        case 'dddd':\n          return weekdays[_this3.$W];\n\n        case 'H':\n          return String($H);\n\n        case 'HH':\n          return Utils.s($H, 2, '0');\n\n        case 'h':\n          return get$H(1);\n\n        case 'hh':\n          return get$H(2);\n\n        case 'a':\n          return meridiemFunc($H, $m, true);\n\n        case 'A':\n          return meridiemFunc($H, $m, false);\n\n        case 'm':\n          return String($m);\n\n        case 'mm':\n          return Utils.s($m, 2, '0');\n\n        case 's':\n          return String(_this3.$s);\n\n        case 'ss':\n          return Utils.s(_this3.$s, 2, '0');\n\n        case 'SSS':\n          return Utils.s(_this3.$ms, 3, '0');\n\n        case 'Z':\n          return zoneStr;\n        // 'ZZ' logic below\n\n        default:\n          break;\n      }\n\n      return null;\n    };\n\n    return str.replace(C.REGEX_FORMAT, function (match, $1) {\n      return $1 || matches(match) || zoneStr.replace(':', '');\n    }); // 'ZZ'\n  };\n\n  _proto.utcOffset = function utcOffset() {\n    // Because a bug at FF24, we're rounding the timezone offset around 15 minutes\n    // https://github.com/moment/moment/pull/1871\n    return -Math.round(this.$d.getTimezoneOffset() / 15) * 15;\n  };\n\n  _proto.diff = function diff(input, units, _float) {\n    var _this4 = this;\n\n    var unit = Utils.p(units);\n    var that = dayjs(input);\n    var zoneDelta = (that.utcOffset() - this.utcOffset()) * C.MILLISECONDS_A_MINUTE;\n    var diff = this - that;\n\n    var getMonth = function getMonth() {\n      return Utils.m(_this4, that);\n    };\n\n    var result;\n\n    switch (unit) {\n      case C.Y:\n        result = getMonth() / 12;\n        break;\n\n      case C.M:\n        result = getMonth();\n        break;\n\n      case C.Q:\n        result = getMonth() / 3;\n        break;\n\n      case C.W:\n        result = (diff - zoneDelta) / C.MILLISECONDS_A_WEEK;\n        break;\n\n      case C.D:\n        result = (diff - zoneDelta) / C.MILLISECONDS_A_DAY;\n        break;\n\n      case C.H:\n        result = diff / C.MILLISECONDS_A_HOUR;\n        break;\n\n      case C.MIN:\n        result = diff / C.MILLISECONDS_A_MINUTE;\n        break;\n\n      case C.S:\n        result = diff / C.MILLISECONDS_A_SECOND;\n        break;\n\n      default:\n        result = diff; // milliseconds\n\n        break;\n    }\n\n    return _float ? result : Utils.a(result);\n  };\n\n  _proto.daysInMonth = function daysInMonth() {\n    return this.endOf(C.M).$D;\n  };\n\n  _proto.$locale = function $locale() {\n    // get locale object\n    return Ls[this.$L];\n  };\n\n  _proto.locale = function locale(preset, object) {\n    if (!preset) return this.$L;\n    var that = this.clone();\n    var nextLocaleName = parseLocale(preset, object, true);\n    if (nextLocaleName) that.$L = nextLocaleName;\n    return that;\n  };\n\n  _proto.clone = function clone() {\n    return Utils.w(this.$d, this);\n  };\n\n  _proto.toDate = function toDate() {\n    return new Date(this.valueOf());\n  };\n\n  _proto.toJSON = function toJSON() {\n    return this.isValid() ? this.toISOString() : null;\n  };\n\n  _proto.toISOString = function toISOString() {\n    // ie 8 return\n    // new Dayjs(this.valueOf() + this.$d.getTimezoneOffset() * 60000)\n    // .format('YYYY-MM-DDTHH:mm:ss.SSS[Z]')\n    return this.$d.toISOString();\n  };\n\n  _proto.toString = function toString() {\n    return this.$d.toUTCString();\n  };\n\n  return Dayjs;\n}();\n\nvar proto = Dayjs.prototype;\ndayjs.prototype = proto;\n[['$ms', C.MS], ['$s', C.S], ['$m', C.MIN], ['$H', C.H], ['$W', C.D], ['$M', C.M], ['$y', C.Y], ['$D', C.DATE]].forEach(function (g) {\n  proto[g[1]] = function (input) {\n    return this.$g(input, g[0], g[1]);\n  };\n});\n\ndayjs.extend = function (plugin, option) {\n  if (!plugin.$i) {\n    // install plugin only once\n    plugin(option, Dayjs, dayjs);\n    plugin.$i = true;\n  }\n\n  return dayjs;\n};\n\ndayjs.locale = parseLocale;\ndayjs.isDayjs = isDayjs;\n\ndayjs.unix = function (timestamp) {\n  return dayjs(timestamp * 1e3);\n};\n\ndayjs.en = Ls[L];\ndayjs.Ls = Ls;\ndayjs.p = {};\nexport default dayjs;","import { FORMAT_DEFAULT } from '../../constant';\nexport default (function (o, c) {\n  // locale needed later\n  var proto = c.prototype;\n  var oldFormat = proto.format;\n\n  proto.format = function (formatStr) {\n    var _this = this;\n\n    var locale = this.$locale();\n\n    if (!this.isValid()) {\n      return oldFormat.bind(this)(formatStr);\n    }\n\n    var utils = this.$utils();\n    var str = formatStr || FORMAT_DEFAULT;\n    var result = str.replace(/\\[([^\\]]+)]|Q|wo|ww|w|WW|W|zzz|z|gggg|GGGG|Do|X|x|k{1,2}|S/g, function (match) {\n      switch (match) {\n        case 'Q':\n          return Math.ceil((_this.$M + 1) / 3);\n\n        case 'Do':\n          return locale.ordinal(_this.$D);\n\n        case 'gggg':\n          return _this.weekYear();\n\n        case 'GGGG':\n          return _this.isoWeekYear();\n\n        case 'wo':\n          return locale.ordinal(_this.week(), 'W');\n        // W for week\n\n        case 'w':\n        case 'ww':\n          return utils.s(_this.week(), match === 'w' ? 1 : 2, '0');\n\n        case 'W':\n        case 'WW':\n          return utils.s(_this.isoWeek(), match === 'W' ? 1 : 2, '0');\n\n        case 'k':\n        case 'kk':\n          return utils.s(String(_this.$H === 0 ? 24 : _this.$H), match === 'k' ? 1 : 2, '0');\n\n        case 'X':\n          return Math.floor(_this.$d.getTime() / 1000);\n\n        case 'x':\n          return _this.$d.getTime();\n\n        case 'z':\n          return \"[\" + _this.offsetName() + \"]\";\n\n        case 'zzz':\n          return \"[\" + _this.offsetName('long') + \"]\";\n\n        default:\n          return match;\n      }\n    });\n    return oldFormat.bind(this)(result);\n  };\n});","import { D, W, Y } from '../../constant';\nvar isoWeekPrettyUnit = 'isoweek';\nexport default (function (o, c, d) {\n  var getYearFirstThursday = function getYearFirstThursday(year, isUtc) {\n    var yearFirstDay = (isUtc ? d.utc : d)().year(year).startOf(Y);\n    var addDiffDays = 4 - yearFirstDay.isoWeekday();\n\n    if (yearFirstDay.isoWeekday() > 4) {\n      addDiffDays += 7;\n    }\n\n    return yearFirstDay.add(addDiffDays, D);\n  };\n\n  var getCurrentWeekThursday = function getCurrentWeekThursday(ins) {\n    return ins.add(4 - ins.isoWeekday(), D);\n  };\n\n  var proto = c.prototype;\n\n  proto.isoWeekYear = function () {\n    var nowWeekThursday = getCurrentWeekThursday(this);\n    return nowWeekThursday.year();\n  };\n\n  proto.isoWeek = function (week) {\n    if (!this.$utils().u(week)) {\n      return this.add((week - this.isoWeek()) * 7, D);\n    }\n\n    var nowWeekThursday = getCurrentWeekThursday(this);\n    var diffWeekThursday = getYearFirstThursday(this.isoWeekYear(), this.$u);\n    return nowWeekThursday.diff(diffWeekThursday, W) + 1;\n  };\n\n  proto.isoWeekday = function (week) {\n    if (!this.$utils().u(week)) {\n      return this.day(this.day() % 7 ? week : week - 7);\n    }\n\n    return this.day() || 7;\n  };\n\n  var oldStartOf = proto.startOf;\n\n  proto.startOf = function (units, startOf) {\n    var utils = this.$utils();\n    var isStartOf = !utils.u(startOf) ? startOf : true;\n    var unit = utils.p(units);\n\n    if (unit === isoWeekPrettyUnit) {\n      return isStartOf ? this.date(this.date() - (this.isoWeekday() - 1)).startOf('day') : this.date(this.date() - 1 - (this.isoWeekday() - 1) + 7).endOf('day');\n    }\n\n    return oldStartOf.bind(this)(units, startOf);\n  };\n});","import dayjs from 'dayjs/esm';\nimport advancedFormat from 'dayjs/esm/plugin/advancedFormat';\nimport isoWeek from 'dayjs/esm/plugin/isoWeek';\n\ndayjs.extend(isoWeek);\ndayjs.extend(advancedFormat);\n\nexport class TemporalCache {\n    private yearMonthDayCache = new Map<string, YearMonthDay>();\n    private yearWeekCache = new Map<string, YearWeek>();\n    private yearMonthCache = new Map<string, YearMonth>();\n    private yearCache = new Map<string, Year>();\n\n    private constructor() {}\n\n    getYearMonthDay(s: string): YearMonthDay {\n        if (!this.yearMonthDayCache.has(s)) {\n            this.yearMonthDayCache.set(s, YearMonthDay.parse(s, this));\n        }\n        return this.yearMonthDayCache.get(s)!;\n    }\n\n    getYearMonth(s: string): YearMonth {\n        if (!this.yearMonthCache.has(s)) {\n            this.yearMonthCache.set(s, YearMonth.parse(s, this));\n        }\n        return this.yearMonthCache.get(s)!;\n    }\n\n    getYearWeek(s: string): YearWeek {\n        if (!this.yearWeekCache.has(s)) {\n            this.yearWeekCache.set(s, YearWeek.parse(s, this));\n        }\n        return this.yearWeekCache.get(s)!;\n    }\n\n    getYear(s: string): Year {\n        if (!this.yearCache.has(s)) {\n            this.yearCache.set(s, Year.parse(s, this));\n        }\n        return this.yearCache.get(s)!;\n    }\n\n    private static instance = new TemporalCache();\n\n    static getInstance(): TemporalCache {\n        return this.instance;\n    }\n}\n\nexport class YearMonthDay {\n    readonly date;\n    readonly dayjs;\n\n    constructor(\n        readonly yearNumber: number,\n        readonly monthNumber: number,\n        readonly dayNumber: number,\n        readonly cache: TemporalCache,\n    ) {\n        this.date = new Date(this.yearNumber, this.monthNumber - 1, this.dayNumber);\n        this.dayjs = dayjs(this.date);\n    }\n\n    get text(): string {\n        return this.dayjs.format('YYYY-MM-DD');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.yearNumber}`);\n    }\n\n    get month(): YearMonth {\n        return this.cache.getYearMonth(this.dayjs.format('YYYY-MM'));\n    }\n\n    get week(): YearWeek {\n        return this.cache.getYearWeek(this.dayjs.format('GGGG-WW'));\n    }\n\n    addDays(days: number): YearMonthDay {\n        const date = this.dayjs.add(days, 'day');\n        const s = date.format('YYYY-MM-DD');\n        return this.cache.getYearMonthDay(s);\n    }\n\n    minus(other: YearMonthDay): number {\n        return this.dayjs.diff(other.dayjs, 'day');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearMonthDay {\n        const [year, month, day] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearMonthDay(year, month, day, cache);\n    }\n}\n\nexport class YearWeek {\n    constructor(\n        readonly isoYearNumber: number,\n        readonly isoWeekNumber: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY-WW');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstDay(): YearMonthDay {\n        // \"The first week of the year, hence, always contains 4 January.\" https://en.wikipedia.org/wiki/ISO_week_date\n        const firstDay = dayjs()\n            .year(this.isoYearNumber)\n            .month(1)\n            .date(4)\n            .isoWeek(this.isoWeekNumber)\n            .startOf('isoWeek');\n        return this.cache.getYearMonthDay(firstDay.format('YYYY-MM-DD'));\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.isoYearNumber}`);\n    }\n\n    addWeeks(weeks: number): YearWeek {\n        const date = this.firstDay.dayjs.add(weeks, 'week');\n        const s = date.format('YYYY-WW');\n        return this.cache.getYearWeek(s);\n    }\n\n    minus(other: YearWeek): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'week');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearWeek {\n        const [year, week] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearWeek(year, week, cache);\n    }\n}\n\nexport class YearMonth {\n    constructor(\n        readonly yearNumber: number,\n        readonly monthNumber: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY-MM');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstDay(): YearMonthDay {\n        return this.cache.getYearMonthDay(dayjs(`${this.yearNumber}-${this.monthNumber}-01`).format('YYYY-MM-DD'));\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.yearNumber}`);\n    }\n\n    addMonths(months: number): YearMonth {\n        const date = this.firstDay.dayjs.add(months, 'month');\n        const s = date.format('YYYY-MM');\n        return this.cache.getYearMonth(s);\n    }\n\n    minus(other: YearMonth): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'month');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearMonth {\n        const [year, month] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearMonth(year, month, cache);\n    }\n}\n\nexport class Year {\n    constructor(\n        readonly year: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstMonth(): YearMonth {\n        return this.cache.getYearMonth(`${this.year}-01`);\n    }\n\n    get firstDay(): YearMonthDay {\n        return this.firstMonth.firstDay;\n    }\n\n    addYears(years: number): Year {\n        const date = this.firstDay.dayjs.add(years, 'year');\n        const s = date.format('YYYY');\n        return this.cache.getYear(s);\n    }\n\n    minus(other: Year): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'year');\n    }\n\n    static parse(s: string, cache: TemporalCache): Year {\n        const year = parseInt(s, 10);\n        return new Year(year, cache);\n    }\n}\n\nexport type Temporal = YearMonthDay | YearWeek | YearMonth | Year;\n\nexport function generateAllDaysInRange(start: YearMonthDay, end: YearMonthDay): YearMonthDay[] {\n    const days = [];\n    const daysInBetween = end.minus(start);\n    for (let i = 0; i <= daysInBetween; i++) {\n        days.push(start.addDays(i));\n    }\n    return days;\n}\n\nexport function generateAllWeeksInRange(start: YearWeek, end: YearWeek): YearWeek[] {\n    const weeks = [];\n    const weeksInBetween = end.minus(start);\n    for (let i = 0; i <= weeksInBetween; i++) {\n        weeks.push(start.addWeeks(i));\n    }\n    return weeks;\n}\n\nexport function generateAllMonthsInRange(start: YearMonth, end: YearMonth): YearMonth[] {\n    const months = [];\n    const monthsInBetween = end.minus(start);\n    for (let i = 0; i <= monthsInBetween; i++) {\n        months.push(start.addMonths(i));\n    }\n    return months;\n}\n\nexport function generateAllYearsInRange(start: Year, end: Year): Year[] {\n    const years = [];\n    const yearsInBetween = end.minus(start);\n    for (let i = 0; i <= yearsInBetween; i++) {\n        years.push(start.addYears(i));\n    }\n    return years;\n}\n\nexport function generateAllInRange(start: Temporal | null, end: Temporal | null): Temporal[] {\n    if (start === null || end === null) {\n        return [];\n    }\n    if (start instanceof YearMonthDay && end instanceof YearMonthDay) {\n        return generateAllDaysInRange(start, end);\n    }\n    if (start instanceof YearWeek && end instanceof YearWeek) {\n        return generateAllWeeksInRange(start, end);\n    }\n    if (start instanceof YearMonth && end instanceof YearMonth) {\n        return generateAllMonthsInRange(start, end);\n    }\n    if (start instanceof Year && end instanceof Year) {\n        return generateAllYearsInRange(start, end);\n    }\n    throw new Error(`Invalid arguments: start and end must be of the same type: ${start}, ${end}`);\n}\n\nexport function minusTemporal(a: Temporal, b: Temporal): number {\n    if (a instanceof YearMonthDay && b instanceof YearMonthDay) {\n        return a.minus(b);\n    }\n    if (a instanceof YearWeek && b instanceof YearWeek) {\n        return a.minus(b);\n    }\n    if (a instanceof YearMonth && b instanceof YearMonth) {\n        return a.minus(b);\n    }\n    if (a instanceof Year && b instanceof Year) {\n        return a.minus(b);\n    }\n    throw new Error(`Cannot compare ${a} and ${b}`);\n}\n\nexport function compareTemporal(a: Temporal | null, b: Temporal | null): number {\n    if (a === null) {\n        return 1;\n    }\n    if (b === null) {\n        return -1;\n    }\n    const diff = minusTemporal(a, b);\n    if (diff < 0) {\n        return -1;\n    }\n    if (diff > 0) {\n        return 1;\n    }\n    return 0;\n}\n\nexport function getMinMaxTemporal(values: Iterable<Temporal | null>): [Temporal, Temporal] | null {\n    let min = null;\n    let max = null;\n    for (const value of values) {\n        if (value === null) {\n            continue;\n        }\n        if (min === null || compareTemporal(value, min) < 0) {\n            min = value;\n        }\n        if (max === null || compareTemporal(value, max) > 0) {\n            max = value;\n        }\n    }\n    if (min === null || max === null) {\n        return null;\n    }\n    return [min, max];\n}\n\nexport function addUnit(temporal: Temporal, amount: number): Temporal {\n    if (temporal instanceof YearMonthDay) {\n        return temporal.addDays(amount);\n    }\n    if (temporal instanceof YearWeek) {\n        return temporal.addWeeks(amount);\n    }\n    if (temporal instanceof YearMonth) {\n        return temporal.addMonths(amount);\n    }\n    if (temporal instanceof Year) {\n        return temporal.addYears(amount);\n    }\n    throw new Error(`Invalid argument: ${temporal}`);\n}\n","import { type LapisFilter } from '../types';\n\nexport function getMinMaxNumber(values: Iterable<number>): [number, number] | null {\n    let min = null;\n    let max = null;\n    for (const value of values) {\n        if (min === null || value < min) {\n            min = value;\n        }\n        if (max === null || value > max) {\n            max = value;\n        }\n    }\n    if (min === null || max === null) {\n        return null;\n    }\n    return [min, max];\n}\n\nexport function mapLapisFilterToUrlParams(filter: LapisFilter): URLSearchParams {\n    const params = Object.entries(filter).map(([key, value]) => [key, stringifyLapisFilterValue(value)]);\n\n    return new URLSearchParams(params);\n}\n\nfunction stringifyLapisFilterValue(value: LapisFilter[string]) {\n    if (value === null) {\n        return 'null';\n    }\n    switch (typeof value) {\n        case 'boolean':\n            return value ? 'true' : 'false';\n        case 'number':\n            return value.toString();\n        case 'string':\n            return value;\n    }\n}\n","import { Chart, type ChartConfiguration, registerables } from 'chart.js';\n\nimport { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { addUnit, minusTemporal } from '../../utils/temporal';\nimport { getMinMaxNumber } from '../../utils/utils';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeBubbleChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst PrevalenceOverTimeBubbleChart = ({ data, yAxisScaleType }: PrevalenceOverTimeBubbleChartProps) => {\n    const firstDate = data[0].content[0].dateRange!;\n    const total = data.map((graphData) => graphData.content.map((dataPoint) => dataPoint.total)).flat();\n    const [minTotal, maxTotal] = getMinMaxNumber(total)!;\n    const scaleBubble = (value: number) => {\n        return ((value - minTotal) / (maxTotal - minTotal)) * 4.5 + 0.5;\n    };\n\n    const config: ChartConfiguration = {\n        type: 'bubble',\n        data: {\n            datasets: data.map((graphData, index) => ({\n                label: graphData.displayName,\n                data: graphData.content\n                    .filter((dataPoint) => dataPoint.dateRange !== null)\n                    .map((dataPoint) => ({\n                        x: minusTemporal(dataPoint.dateRange!, firstDate),\n                        y: dataPoint.prevalence,\n                        r: scaleBubble(dataPoint.total),\n                    })),\n                borderWidth: 1,\n                pointRadius: 0,\n                backgroundColor: singleGraphColorRGBAById(index, 0.3),\n                borderColor: singleGraphColorRGBAById(index),\n            })),\n        },\n        options: {\n            animation: false,\n            scales: {\n                x: {\n                    ticks: {\n                        callback: (value) => addUnit(firstDate, value as number).toString(),\n                    },\n                },\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: {\n                    mode: 'index',\n                    intersect: false,\n                    callbacks: {\n                        title: (context) => {\n                            const dataset = data[context[0].datasetIndex!];\n                            const dataPoint = dataset.content[context[0].dataIndex!];\n                            return dataPoint.dateRange?.toString();\n                        },\n                        label: (context) => {\n                            const dataset = data[context.datasetIndex!];\n                            const dataPoint = dataset.content[context.dataIndex!];\n\n                            const percentage = (dataPoint.prevalence * 100).toFixed(2);\n                            const count = dataPoint.count.toFixed(0);\n                            const total = dataPoint.total.toFixed(0);\n\n                            return `${dataset.displayName}: ${percentage}%, ${count}/${total} samples`;\n                        },\n                    },\n                },\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nexport default PrevalenceOverTimeBubbleChart;\n","import { Chart, type ChartConfiguration, registerables } from 'chart.js';\nimport { type TooltipItem } from 'chart.js/dist/types';\n\nimport { type PrevalenceOverTimeData, type PrevalenceOverTimeVariantData } from '../../query/queryPrevalenceOverTime';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport {\n    confidenceIntervalDataLabel,\n    type ConfidenceIntervalMethod,\n    wilson95PercentConfidenceInterval,\n} from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeLineChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst PrevalenceOverTimeLineChart = ({\n    data,\n    yAxisScaleType,\n    confidenceIntervalMethod,\n}: PrevalenceOverTimeLineChartProps) => {\n    const datasets = data.map((graphData, index) => getDataset(graphData, index, confidenceIntervalMethod)).flat();\n    const labels = data[0]?.content.map((dateRange) => dateRange.dateRange?.toString() ?? 'Unknown') || [];\n\n    const config: ChartConfiguration = {\n        type: 'line',\n        data: {\n            labels,\n            datasets,\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(confidenceIntervalMethod),\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nconst getDataset = (\n    prevalenceOverTimeVariant: PrevalenceOverTimeVariantData,\n    dataIndex: number,\n    confidenceIntervalMethod: ConfidenceIntervalMethod,\n) => {\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return [\n                getDatasetCIUpper(prevalenceOverTimeVariant, dataIndex),\n                getDatasetLine(prevalenceOverTimeVariant, dataIndex),\n                getDatasetCILower(prevalenceOverTimeVariant, dataIndex),\n            ].flat();\n        default:\n            return getDatasetLine(prevalenceOverTimeVariant, dataIndex);\n    }\n};\n\nconst getDatasetCIUpper = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: `${prevalenceOverTimeVariant.displayName} CI upper`,\n    data: prevalenceOverTimeVariant.content.map(\n        (dataPoint) => wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).upperLimit,\n    ),\n    borderWidth: 0,\n    pointRadius: 0,\n    fill: '+1',\n    backgroundColor: singleGraphColorRGBAById(dataIndex, 0.3),\n});\n\nconst getDatasetCILower = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: `${prevalenceOverTimeVariant.displayName} CI lower`,\n    data: prevalenceOverTimeVariant.content.map(\n        (dataPoint) => wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).lowerLimit,\n    ),\n    borderWidth: 0,\n    pointRadius: 0,\n    fill: '-1',\n    backgroundColor: singleGraphColorRGBAById(dataIndex, 0.3),\n});\n\nconst getDatasetLine = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: prevalenceOverTimeVariant.displayName,\n    data: prevalenceOverTimeVariant.content.map((dataPoint) => dataPoint.prevalence),\n    borderWidth: 1,\n    pointRadius: 0,\n    borderColor: singleGraphColorRGBAById(dataIndex),\n    backgroundColor: singleGraphColorRGBAById(dataIndex),\n});\n\nconst tooltip = (confidenceIntervalMethod?: ConfidenceIntervalMethod) => {\n    const generalConfig = {\n        mode: 'index' as const,\n        intersect: false,\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                filter: ({ datasetIndex }: TooltipItem<'line'>) => {\n                    return datasetIndex % 3 === 1;\n                },\n                callbacks: {\n                    label: (context: TooltipItem<'line'>) => {\n                        if (context.datasetIndex % 3 === 1) {\n                            const value = context.dataset.data[context.dataIndex];\n                            const ciLower = context.dataset.data[context.dataIndex - 1];\n                            const ciUpper = context.dataset.data[context.dataIndex + 1];\n\n                            if (\n                                typeof value !== 'number' ||\n                                typeof ciLower !== 'number' ||\n                                typeof ciUpper !== 'number'\n                            ) {\n                                return '';\n                            }\n\n                            return confidenceIntervalDataLabel(value, ciLower, ciUpper, context.dataset.label);\n                        }\n                        return context.dataset.label;\n                    },\n                },\n            };\n        default:\n            return generalConfig;\n    }\n};\n\nexport default PrevalenceOverTimeLineChart;\n","import { getPrevalenceOverTimeTableData } from './getPrevalenceOverTimeTableData';\nimport { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { type TemporalGranularity } from '../../types';\nimport { Table } from '../components/table';\nimport { formatProportion } from '../shared/table/formatProportion';\n\ninterface PrevalenceOverTimeTableProps {\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n}\n\nconst PrevalenceOverTimeTable = ({ data, granularity }: PrevalenceOverTimeTableProps) => {\n    const getSplitColumns = (data: PrevalenceOverTimeData) => {\n        return data.map((dataset) => ({\n            name: dataset.displayName,\n            columns: [\n                {\n                    name: 'prevalence',\n                    sort: true,\n                    formatter: (cell: number) => formatProportion(cell),\n                },\n                {\n                    name: 'count',\n                    sort: true,\n                },\n            ],\n        }));\n    };\n\n    const getColumns = (data: PrevalenceOverTimeData) => [\n        {\n            name: granularity,\n            sort: true,\n        },\n        ...getSplitColumns(data),\n    ];\n\n    const getData = (data: PrevalenceOverTimeData, granularity: TemporalGranularity) => {\n        const dataByHeader = getPrevalenceOverTimeTableData(data, granularity);\n        return Object.values(dataByHeader).map((row) => Object.values(row));\n    };\n\n    return <Table data={getData(data, granularity)} columns={getColumns(data)} pagination={false} />;\n};\n\nexport default PrevalenceOverTimeTable;\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { type MappedNumber, type NumberFields } from '../utils/type-utils';\n\nexport type DivisionOperatorResult<\n    KeyField extends keyof ValueObject,\n    ValueObject,\n    ResultField extends string,\n    NumeratorField extends string,\n    DenominatorField extends string,\n> = { [P in KeyField]: ValueObject[KeyField] } & MappedNumber<ResultField> &\n    MappedNumber<NumeratorField> &\n    MappedNumber<DenominatorField>;\n\nexport class DivisionOperator<\n    ValueObject,\n    KeyField extends keyof ValueObject,\n    ValueField extends NumberFields<ValueObject>,\n    ResultField extends string,\n    NumeratorField extends string,\n    DenominatorField extends string,\n> implements Operator<DivisionOperatorResult<KeyField, ValueObject, ResultField, NumeratorField, DenominatorField>>\n{\n    constructor(\n        private numerator: Operator<ValueObject>,\n        private denominator: Operator<ValueObject>,\n        private keyField: KeyField,\n        private valueField: ValueField,\n        private resultField: ResultField,\n        private numeratorField: NumeratorField,\n        private denominatorField: DenominatorField,\n    ) {}\n\n    async evaluate(\n        lapis: string,\n        signal?: AbortSignal,\n    ): Promise<Dataset<DivisionOperatorResult<KeyField, ValueObject, ResultField, NumeratorField, DenominatorField>>> {\n        const numeratorEvaluated = await this.numerator.evaluate(lapis, signal);\n        const denominatorEvaluated = await this.denominator.evaluate(lapis, signal);\n\n        const numeratorMap = new Map<ValueObject[KeyField], ValueObject[ValueField]>();\n        numeratorEvaluated.content.forEach((row) => {\n            numeratorMap.set(row[this.keyField], row[this.valueField]);\n        });\n\n        const content = denominatorEvaluated.content.map((row) => {\n            const numeratorValue = numeratorMap.get(row[this.keyField]) ?? 0;\n            return {\n                [this.keyField]: row[this.keyField],\n                [this.numeratorField]: numeratorValue as number,\n                [this.denominatorField]: row[this.valueField] as number,\n                [this.resultField]: (numeratorValue as number) / (row[this.valueField] as number),\n            } as { [P in KeyField]: ValueObject[KeyField] } & MappedNumber<ResultField> &\n                MappedNumber<NumeratorField> &\n                MappedNumber<DenominatorField>;\n        });\n\n        return { content };\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchAggregated } from '../lapisApi/lapisApi';\nimport { type AggregatedItem } from '../lapisApi/lapisTypes';\nimport { type LapisFilter } from '../types';\n\nexport class FetchAggregatedOperator<Fields extends Record<string, unknown>>\n    implements\n        Operator<\n            Fields & {\n                count: number;\n            }\n        >\n{\n    constructor(\n        private filter: LapisFilter,\n        private fields: string[],\n    ) {}\n\n    async evaluate(lapisUrl: string, signal?: AbortSignal): Promise<Dataset<Fields & { count: number }>> {\n        const aggregatedResponse = (\n            await fetchAggregated(\n                lapisUrl,\n                {\n                    ...this.filter,\n                    fields: this.fields,\n                },\n                signal,\n            )\n        ).data;\n\n        if (isFieldsArrayWithCount<Fields & { count: number }>(aggregatedResponse)) {\n            return {\n                content: aggregatedResponse,\n            };\n        }\n\n        throw new Error('Aggregated response does not have count');\n    }\n}\n\nfunction isFieldsArrayWithCount<T>(data: AggregatedItem[]): data is (T & { count: number })[] {\n    return data.every((item) => typeof item === 'object' && 'count' in item && typeof item.count === 'number');\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class FillMissingOperator<Data, KeyToFill extends keyof Data> implements Operator<Data> {\n    constructor(\n        private child: Operator<Data>,\n        private keyField: KeyToFill,\n        private getMinMaxFn: (values: Iterable<Data[KeyToFill]>) => [Data[KeyToFill], Data[KeyToFill]] | null,\n        private getAllRequiredKeysFn: (min: Data[KeyToFill], max: Data[KeyToFill]) => Data[KeyToFill][],\n        private defaultValueFn: (key: Data[KeyToFill]) => Data,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<Data>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const existingKeys = new Set(childEvaluated.content.map((row) => row[this.keyField]));\n        const minMax = this.getMinMaxFn(existingKeys);\n        if (minMax === null) {\n            return childEvaluated;\n        }\n        const [min, max] = minMax;\n        const requiredKeys = this.getAllRequiredKeysFn(min, max);\n        const content = childEvaluated.content;\n        for (const key of requiredKeys) {\n            if (!existingKeys.has(key)) {\n                content.push(this.defaultValueFn(key));\n            }\n        }\n        return { content };\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class GroupByOperator<Data, AggregationResult, KeyToGroupBy extends keyof Data>\n    implements Operator<AggregationResult>\n{\n    constructor(\n        private child: Operator<Data>,\n        private field: KeyToGroupBy,\n        private aggregate: (values: Data[]) => AggregationResult,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<AggregationResult>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const grouped = new Map<Data[KeyToGroupBy], Data[]>();\n        for (const row of childEvaluated.content) {\n            const key = row[this.field];\n            if (!grouped.has(key)) {\n                grouped.set(key, []);\n            }\n            grouped.get(key)!.push(row);\n        }\n        const result = new Array<AggregationResult>();\n        for (const [, values] of grouped) {\n            result.push(this.aggregate(values));\n        }\n\n        return {\n            content: result,\n        };\n    }\n}\n","import { GroupByOperator } from './GroupByOperator';\nimport { type Operator } from './Operator';\nimport { type NumberFields } from '../utils/type-utils';\n\ntype Result<Data, KeyToGroupBy extends keyof Data, KeyToSumBy extends keyof Data> = {\n    [P in KeyToGroupBy | KeyToSumBy]: P extends KeyToGroupBy ? Data[KeyToGroupBy] : number;\n};\n\nexport class GroupByAndSumOperator<\n    Data,\n    KeyToGroupBy extends keyof Data,\n    KeySoSumBy extends NumberFields<Data>,\n> extends GroupByOperator<Data, Result<Data, KeyToGroupBy, KeySoSumBy>, KeyToGroupBy> {\n    constructor(child: Operator<Data>, groupByField: KeyToGroupBy, sumField: KeySoSumBy) {\n        super(child, groupByField, (values: Data[]) => {\n            let n = 0;\n            for (const value of values) {\n                n += value[sumField] as number;\n            }\n            return {\n                [groupByField]: values[0][groupByField],\n                [sumField]: n,\n            } as Result<Data, KeyToGroupBy, KeySoSumBy>;\n        });\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class MapOperator<S, T> implements Operator<T> {\n    constructor(\n        private child: Operator<S>,\n        private func: (value: S) => T,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<T>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        return {\n            content: childEvaluated.content.map(this.func),\n        };\n    }\n}\n","import { type Operator } from './Operator';\n\nexport class SlidingOperator<Data, AggregationResult> implements Operator<AggregationResult> {\n    constructor(\n        private child: Operator<Data>,\n        private windowSize: number,\n        private aggregate: (values: Data[]) => AggregationResult,\n    ) {\n        if (windowSize < 1) {\n            throw new Error('Window size must be at least 1');\n        }\n    }\n\n    async evaluate(lapis: string, signal?: AbortSignal) {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const content = new Array<AggregationResult>();\n        const numberOfWindows = Math.max(childEvaluated.content.length - this.windowSize, 0) + 1;\n        for (let i = 0; i < numberOfWindows; i++) {\n            content.push(this.aggregate(childEvaluated.content.slice(i, i + this.windowSize)));\n        }\n        return { content };\n    }\n}\n","import { DivisionOperator } from '../operator/DivisionOperator';\nimport { FetchAggregatedOperator } from '../operator/FetchAggregatedOperator';\nimport { FillMissingOperator } from '../operator/FillMissingOperator';\nimport { GroupByAndSumOperator } from '../operator/GroupByAndSumOperator';\nimport { MapOperator } from '../operator/MapOperator';\nimport { SlidingOperator } from '../operator/SlidingOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type NamedLapisFilter, type TemporalGranularity } from '../types';\nimport {\n    compareTemporal,\n    generateAllInRange,\n    getMinMaxTemporal,\n    type Temporal,\n    TemporalCache,\n} from '../utils/temporal';\n\nexport type PrevalenceOverTimeData = PrevalenceOverTimeVariantData[];\n\nexport type PrevalenceOverTimeVariantData = {\n    displayName: string;\n    content: { count: number; prevalence: number; total: number; dateRange: Temporal | null }[];\n};\n\nexport function queryPrevalenceOverTime(\n    numeratorFilter: NamedLapisFilter | NamedLapisFilter[],\n    denominatorFilter: NamedLapisFilter,\n    granularity: TemporalGranularity,\n    smoothingWindow: number,\n    lapis: string,\n    signal?: AbortSignal,\n): Promise<PrevalenceOverTimeData> {\n    const numeratorFilters = makeArray(numeratorFilter);\n\n    const denominatorData = fetchAndPrepare(getFilter(denominatorFilter), granularity, smoothingWindow);\n    const subQueries = numeratorFilters.map(async (namedLapisFilter) => {\n        const { displayName, ...filter } = namedLapisFilter;\n        const numeratorData = fetchAndPrepare(filter, granularity, smoothingWindow);\n        const divide = new DivisionOperator(\n            numeratorData,\n            denominatorData,\n            'dateRange',\n            'count',\n            'prevalence',\n            'count',\n            'total',\n        );\n        const dataset = await divide.evaluate(lapis, signal);\n        return {\n            displayName,\n            content: dataset.content,\n        };\n    });\n    return Promise.all(subQueries);\n}\n\nfunction getFilter(filter: NamedLapisFilter) {\n    // eslint-disable-next-line @typescript-eslint/no-unused-vars\n    const { displayName, ...filterWithoutDisplayName } = filter;\n    return filterWithoutDisplayName;\n}\n\nfunction makeArray<T>(arrayOrSingleItem: T | T[]) {\n    if (Array.isArray(arrayOrSingleItem)) {\n        return arrayOrSingleItem;\n    }\n    return [arrayOrSingleItem];\n}\n\nfunction fetchAndPrepare(filter: LapisFilter, granularity: TemporalGranularity, smoothingWindow: number) {\n    const fetchData = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(filter, ['date']);\n    const mapData = new MapOperator(fetchData, (d) => mapDateToGranularityRange(d, granularity));\n    const groupByData = new GroupByAndSumOperator(mapData, 'dateRange', 'count');\n    const fillData = new FillMissingOperator(\n        groupByData,\n        'dateRange',\n        getMinMaxTemporal,\n        generateAllInRange,\n        (key) => ({ dateRange: key, count: 0 }),\n    );\n    const sortData = new SortOperator(fillData, dateRangeCompare);\n\n    return smoothingWindow >= 1 ? new SlidingOperator(sortData, smoothingWindow, averageSmoothing) : sortData;\n}\n\nfunction mapDateToGranularityRange(d: { date: string | null; count: number }, granularity: TemporalGranularity) {\n    let dateRange: Temporal | null = null;\n    if (d.date !== null) {\n        const date = TemporalCache.getInstance().getYearMonthDay(d.date);\n        switch (granularity) {\n            case 'day':\n                dateRange = date;\n                break;\n            case 'week':\n                dateRange = date.week;\n                break;\n            case 'month':\n                dateRange = date.month;\n                break;\n            case 'year':\n                dateRange = date.year;\n                break;\n        }\n    }\n    return {\n        dateRange,\n        count: d.count,\n    };\n}\n\nfunction dateRangeCompare(a: { dateRange: Temporal | null }, b: { dateRange: Temporal | null }) {\n    if (a.dateRange === null) {\n        return 1;\n    }\n    if (b.dateRange === null) {\n        return -1;\n    }\n    return compareTemporal(a.dateRange, b.dateRange);\n}\n\nfunction averageSmoothing(slidingWindow: { dateRange: Temporal | null; count: number }[]) {\n    const average = slidingWindow.reduce((acc, curr) => acc + curr.count, 0) / slidingWindow.length;\n    const centerIndex = Math.floor(slidingWindow.length / 2);\n    return { dateRange: slidingWindow[centerIndex].dateRange, count: average };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type JSXInternal } from 'preact/src/jsx';\n\nexport interface SelectProps {\n    items: { label: string; value: string; disabled?: boolean }[];\n    selected: string;\n    onChange: JSXInternal.GenericEventHandler<HTMLSelectElement>;\n    selectStyle?: string;\n}\n\nexport const Select: FunctionComponent<SelectProps> = ({ items, selected, onChange, selectStyle }) => {\n    return (\n        <select class={`select select-bordered ${selectStyle}`} value={selected} onChange={onChange}>\n            {items.map((item) => (\n                <option key={item.value} value={item.value} disabled={item.disabled}>\n                    {item.label}\n                </option>\n            ))}\n        </select>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { Select } from './select';\nimport type { ConfidenceIntervalMethod } from '../shared/charts/confideceInterval';\n\ntype ConfidenceIntervalSelectorProps = {\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n    setConfidenceIntervalMethod: (method: ConfidenceIntervalMethod) => void;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n};\n\nexport const ConfidenceIntervalSelector: FunctionComponent<ConfidenceIntervalSelectorProps> = ({\n    confidenceIntervalMethod,\n    setConfidenceIntervalMethod,\n    confidenceIntervalMethods,\n}) => {\n    if (confidenceIntervalMethods.length === 0) {\n        return null;\n    }\n\n    const items = [\n        { label: 'Confidence interval method', value: 'none', disabled: true },\n        ...confidenceIntervalMethods.concat('none').map((method) => {\n            switch (method) {\n                case 'wilson':\n                    return { label: 'Wilson, 95% CI', value: 'wilson' };\n                case 'none':\n                    return { label: 'None', value: 'none' };\n            }\n        }),\n    ];\n\n    return (\n        <Select\n            items={items}\n            selected={confidenceIntervalMethod === undefined ? 'none' : confidenceIntervalMethod}\n            onChange={(event: Event) => {\n                const select = event.target as HTMLSelectElement;\n                const value = select.value as ConfidenceIntervalMethod;\n                setConfidenceIntervalMethod(value);\n            }}\n            selectStyle={'select-xs select-bordered'}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { Select } from './select';\nimport type { ScaleType } from '../shared/charts/getYAxisScale';\n\nexport type ScalingSelectorProps = {\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    className?: string;\n};\n\nexport const ScalingSelector: FunctionComponent<ScalingSelectorProps> = ({\n    yAxisScaleType,\n    setYAxisScaleType,\n    className,\n}) => {\n    const items = [\n        { label: 'y axis scaling type', value: 'none', disabled: true },\n        { label: 'Linear', value: 'linear' },\n        { label: 'Logarithmic', value: 'logarithmic' },\n        { label: 'Logit', value: 'logit' },\n    ];\n\n    return (\n        <Select\n            items={items}\n            selected={yAxisScaleType}\n            onChange={(event: Event) => {\n                const select = event.target as HTMLSelectElement;\n                const value = select.value as ScaleType;\n                setYAxisScaleType(value);\n            }}\n            selectStyle={`${className} select-xs select-bordered`}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport { getPrevalenceOverTimeTableData } from './getPrevalenceOverTimeTableData';\nimport PrevalenceOverTimeBarChart from './prevalence-over-time-bar-chart';\nimport PrevalenceOverTimeBubbleChart from './prevalence-over-time-bubble-chart';\nimport PrevalenceOverTimeLineChart from './prevalence-over-time-line-chart';\nimport PrevalenceOverTimeTable from './prevalence-over-time-table';\nimport { type PrevalenceOverTimeData, queryPrevalenceOverTime } from '../../query/queryPrevalenceOverTime';\nimport { type NamedLapisFilter, type TemporalGranularity } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ConfidenceIntervalSelector } from '../components/confidence-interval-selector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { ScalingSelector } from '../components/scaling-selector';\nimport Tabs from '../components/tabs';\nimport { type ConfidenceIntervalMethod } from '../shared/charts/confideceInterval';\nimport { type ScaleType } from '../shared/charts/getYAxisScale';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'bar' | 'line' | 'bubble' | 'table';\n\nexport interface PrevalenceOverTimeProps {\n    numerator: NamedLapisFilter | NamedLapisFilter[];\n    denominator: NamedLapisFilter;\n    granularity: TemporalGranularity;\n    smoothingWindow: number;\n    views: View[];\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n}\n\nexport const PrevalenceOverTime: FunctionComponent<PrevalenceOverTimeProps> = ({\n    numerator,\n    denominator,\n    granularity,\n    smoothingWindow,\n    views,\n    confidenceIntervalMethods,\n}) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const { data, error, isLoading } = useQuery(\n        () => queryPrevalenceOverTime(numerator, denominator, granularity, smoothingWindow, lapis),\n        [lapis, numerator, denominator, granularity, smoothingWindow],\n    );\n\n    const headline = 'Prevalence over time';\n\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <PrevalenceOverTimeTabs\n                views={views}\n                data={data}\n                granularity={granularity}\n                confidenceIntervalMethods={confidenceIntervalMethods}\n            />\n        </Headline>\n    );\n};\n\ntype PrevalenceOverTimeTabsProps = {\n    views: View[];\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n};\n\nconst PrevalenceOverTimeTabs: FunctionComponent<PrevalenceOverTimeTabsProps> = ({\n    views,\n    data,\n    granularity,\n    confidenceIntervalMethods,\n}) => {\n    const [yAxisScaleType, setYAxisScaleType] = useState<ScaleType>('linear');\n    const [confidenceIntervalMethod, setConfidenceIntervalMethod] = useState<ConfidenceIntervalMethod>(\n        confidenceIntervalMethods.length > 0 ? confidenceIntervalMethods[0] : 'none',\n    );\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'bar':\n                return {\n                    title: 'Bar',\n                    content: (\n                        <PrevalenceOverTimeBarChart\n                            data={data}\n                            yAxisScaleType={yAxisScaleType}\n                            confidenceIntervalMethod={confidenceIntervalMethod}\n                        />\n                    ),\n                };\n            case 'line':\n                return {\n                    title: 'Line',\n                    content: (\n                        <PrevalenceOverTimeLineChart\n                            data={data}\n                            yAxisScaleType={yAxisScaleType}\n                            confidenceIntervalMethod={confidenceIntervalMethod}\n                        />\n                    ),\n                };\n            case 'bubble':\n                return {\n                    title: 'Bubble',\n                    content: <PrevalenceOverTimeBubbleChart data={data} yAxisScaleType={yAxisScaleType} />,\n                };\n            case 'table':\n                return { title: 'Table', content: <PrevalenceOverTimeTable data={data} granularity={granularity} /> };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    const toolbar = (activeTab: string) => (\n        <Toolbar\n            activeTab={activeTab}\n            yAxisScaleType={yAxisScaleType}\n            setYAxisScaleType={setYAxisScaleType}\n            data={data}\n            granularity={granularity}\n            confidenceIntervalMethods={confidenceIntervalMethods}\n            confidenceIntervalMethod={confidenceIntervalMethod}\n            setConfidenceIntervalMethod={setConfidenceIntervalMethod}\n        />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype ToolbarProps = {\n    activeTab: string;\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n    setConfidenceIntervalMethod: (confidenceIntervalMethod: ConfidenceIntervalMethod) => void;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    activeTab,\n    yAxisScaleType,\n    setYAxisScaleType,\n    confidenceIntervalMethods,\n    confidenceIntervalMethod,\n    setConfidenceIntervalMethod,\n    data,\n    granularity,\n}) => {\n    return (\n        <div class='flex'>\n            {activeTab !== 'Table' && (\n                <ScalingSelector yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n            )}\n            {(activeTab === 'Bar' || activeTab === 'Line') && (\n                <ConfidenceIntervalSelector\n                    confidenceIntervalMethods={confidenceIntervalMethods}\n                    confidenceIntervalMethod={confidenceIntervalMethod}\n                    setConfidenceIntervalMethod={setConfidenceIntervalMethod}\n                />\n            )}\n            <CsvDownloadButton\n                className='mx-1 btn btn-xs'\n                getData={() => getPrevalenceOverTimeTableData(data, granularity)}\n                filename='prevalence-over-time.csv'\n            />\n            <Info className='ml-1' content='Info for prevalence over time' />\n        </div>\n    );\n};\n\nexport default PrevalenceOverTime;\n","import { customElement, property } from 'lit/decorators.js';\n\nimport PrevalenceOverTime, { type View } from '../../preact/prevalenceOverTime/prevalence-over-time';\nimport { type ConfidenceIntervalMethod } from '../../preact/shared/charts/confideceInterval';\nimport { type NamedLapisFilter, type TemporalGranularity } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-prevalence-over-time')\nexport class PrevalenceOverTimeComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Object })\n    numerator: NamedLapisFilter | NamedLapisFilter[] = { displayName: '' };\n\n    @property({ type: Object })\n    denominator: NamedLapisFilter = { displayName: '' };\n\n    @property({ type: String })\n    granularity: TemporalGranularity = 'day';\n\n    @property({ type: Number })\n    smoothingWindow: number = 0;\n\n    @property({ type: Array })\n    views: View[] = ['bar', 'line', 'bubble', 'table'];\n\n    @property({ type: Array })\n    confidenceIntervalMethods: ConfidenceIntervalMethod[] = ['wilson'];\n\n    override render() {\n        return (\n            <PrevalenceOverTime\n                numerator={this.numerator}\n                denominator={this.denominator}\n                granularity={this.granularity}\n                smoothingWindow={this.smoothingWindow}\n                views={this.views}\n                confidenceIntervalMethods={this.confidenceIntervalMethods}\n            />\n        );\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-prevalence-over-time': PrevalenceOverTimeComponent;\n    }\n}\n","import { Chart, type ChartConfiguration, registerables, type TooltipItem } from 'chart.js';\n\nimport { type YearMonthDay } from '../../utils/temporal';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBByName } from '../shared/charts/colors';\nimport { confidenceIntervalDataLabel } from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface RelativeGrowthAdvantageChartData {\n    t: YearMonthDay[];\n    proportion: number[];\n    ciLower: number[];\n    ciUpper: number[];\n    observed: number[];\n    params: {\n        fd: {\n            value: number;\n            ciLower: number;\n            ciUpper: number;\n        };\n    };\n}\n\ninterface RelativeGrowthAdvantageChartProps {\n    data: RelativeGrowthAdvantageChartData;\n    yAxisScaleType: ScaleType;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst RelativeGrowthAdvantageChart = ({ data, yAxisScaleType }: RelativeGrowthAdvantageChartProps) => {\n    const config: ChartConfiguration = {\n        type: 'line',\n        data: {\n            labels: data.t,\n            datasets: datasets(data),\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(),\n            },\n        },\n    };\n\n    return (\n        <>\n            <GsChart configuration={config} />\n            <div>\n                Advantage: {(data.params.fd.value * 100).toFixed(2)}% ({(data.params.fd.ciLower * 100).toFixed(2)}% -{' '}\n                {(data.params.fd.ciUpper * 100).toFixed(2)}%)\n            </div>\n        </>\n    );\n};\n\nconst datasets = (data: RelativeGrowthAdvantageChartData) => {\n    return [\n        {\n            type: 'line' as const,\n            label: 'Prevalence',\n            data: data.proportion,\n            borderWidth: 1,\n            pointRadius: 0,\n            borderColor: singleGraphColorRGBByName('indigo'),\n            backgroundColor: singleGraphColorRGBByName('indigo'),\n        },\n        {\n            type: 'line' as const,\n            label: 'CI Lower',\n            data: data.ciLower,\n            borderWidth: 1,\n            pointRadius: 0,\n            fill: '+1',\n            backgroundColor: singleGraphColorRGBByName('indigo', 0.3),\n        },\n        {\n            type: 'line' as const,\n            label: 'CI Upper',\n            data: data.ciUpper,\n            borderWidth: 1,\n            pointRadius: 0,\n            fill: '-1',\n            backgroundColor: singleGraphColorRGBByName('indigo', 0.3),\n        },\n        {\n            type: 'scatter' as const,\n            label: 'Observed',\n            data: data.observed,\n            pointBackgroundColor: singleGraphColorRGBByName('green'),\n            pointRadius: 2,\n        },\n    ];\n};\n\nconst tooltip = () => {\n    return {\n        mode: 'index' as const,\n        intersect: false,\n        filter: ({ datasetIndex }: TooltipItem<'line'>) => {\n            return datasetIndex !== 1 && datasetIndex !== 2;\n        },\n        callbacks: {\n            label: (context: TooltipItem<'line'>) => {\n                switch (context.datasetIndex) {\n                    case 0: {\n                        const value = context.dataset.data[context.dataIndex];\n                        const ciLower = context.dataset.data[context.dataIndex + 1];\n                        const ciUpper = context.dataset.data[context.dataIndex + 2];\n                        if (typeof value !== 'number' || typeof ciLower !== 'number' || typeof ciUpper !== 'number') {\n                            return '';\n                        }\n                        return confidenceIntervalDataLabel(value, ciLower, ciUpper, context.dataset.label);\n                    }\n\n                    case 3: {\n                        const value = context.dataset.data[context.dataIndex];\n                        if (typeof value !== 'number') {\n                            return '';\n                        }\n                        return `Observed: ${value.toFixed(3)}`;\n                    }\n                    default:\n                        return '';\n                }\n            },\n        },\n    };\n};\n\nexport default RelativeGrowthAdvantageChart;\n","import { FetchAggregatedOperator } from '../operator/FetchAggregatedOperator';\nimport { MapOperator } from '../operator/MapOperator';\nimport { type LapisFilter } from '../types';\nimport { getMinMaxTemporal, TemporalCache, type YearMonthDay } from '../utils/temporal';\n\nexport type RelativeGrowthAdvantageData = Awaited<ReturnType<typeof queryRelativeGrowthAdvantage>>;\n\nexport async function queryRelativeGrowthAdvantage(\n    numerator: LapisFilter,\n    denominator: LapisFilter,\n    generationTime: number,\n    lapis: string,\n    signal?: AbortSignal,\n) {\n    const fetchNumerator = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(numerator, ['date']);\n    const fetchDenominator = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(denominator, ['date']);\n    const mapNumerator = new MapOperator(fetchNumerator, toYearMonthDay);\n    const mapDenominator = new MapOperator(fetchDenominator, toYearMonthDay);\n    const [numeratorData, denominatorData] = await Promise.all([\n        mapNumerator.evaluate(lapis, signal),\n        mapDenominator.evaluate(lapis, signal),\n    ]);\n    const minMaxDate = getMinMaxTemporal(denominatorData.content.map((d) => d.date));\n    if (!minMaxDate) {\n        return null;\n    }\n    const [minDate, maxDate] = minMaxDate as [YearMonthDay, YearMonthDay];\n    const numeratorCounts = new Map<YearMonthDay, number>();\n    numeratorData.content.forEach((d) => {\n        if (d.date) {\n            numeratorCounts.set(d.date, d.count);\n        }\n    });\n    const denominatorCounts = new Map<YearMonthDay, number>();\n    const requestData = {\n        t: [] as number[],\n        n: [] as number[],\n        k: [] as number[],\n    };\n    denominatorData.content.forEach((d) => {\n        if (d.date) {\n            denominatorCounts.set(d.date, d.count);\n            const t = d.date.minus(minDate);\n            requestData.t.push(t);\n            requestData.n.push(d.count);\n            requestData.k.push(numeratorCounts.get(d.date) ?? 0);\n        }\n    });\n    const requestPayload = {\n        config: {\n            alpha: 0.95,\n            generationTime,\n            initialCasesVariant: 1,\n            initialCasesWildtype: 1,\n            reproductionNumberWildtype: 1,\n            tStart: 0,\n            tEnd: maxDate.minus(minDate),\n        },\n        data: requestData,\n    };\n    const response = await fetch('https://cov-spectrum.org/api/v2/computed/model/chen2021Fitness', {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(requestPayload),\n        signal,\n    });\n    const responseData = (await response.json()) as {\n        estimatedAbsoluteNumbers: {\n            t: number[];\n            variantCases: number[];\n            wildtypeCases: number[];\n        };\n        estimatedProportions: {\n            t: number[];\n            proportion: number[];\n            ciLower: number[];\n            ciUpper: number[];\n        };\n        params: {\n            a: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            fc: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            fd: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            t0: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n        };\n    };\n    const transformed = {\n        ...responseData,\n        estimatedProportions: {\n            ...responseData.estimatedProportions,\n            t: responseData.estimatedProportions.t.map((t) => minDate.addDays(t)),\n        },\n    };\n    const observedProportions = transformed.estimatedProportions.t.map(\n        (t) => (numeratorCounts.get(t) ?? 0) / (denominatorCounts.get(t) ?? 0),\n    );\n\n    return {\n        ...transformed,\n        observedProportions,\n    };\n}\n\nfunction toYearMonthDay(d: { date: string | null; count: number }) {\n    const temporalCache = TemporalCache.getInstance();\n    return {\n        date: d.date ? temporalCache.getYearMonthDay(d.date) : null,\n        count: d.count,\n    };\n}\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport RelativeGrowthAdvantageChart from './relative-growth-advantage-chart';\nimport {\n    queryRelativeGrowthAdvantage,\n    type RelativeGrowthAdvantageData,\n} from '../../query/queryRelativeGrowthAdvantage';\nimport { type LapisFilter } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { ScalingSelector } from '../components/scaling-selector';\nimport Tabs from '../components/tabs';\nimport { type ScaleType } from '../shared/charts/getYAxisScale';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'line';\n\nexport interface RelativeGrowthAdvantageProps {\n    numerator: LapisFilter;\n    denominator: LapisFilter;\n    generationTime: number;\n    views: View[];\n}\n\nexport const RelativeGrowthAdvantage: FunctionComponent<RelativeGrowthAdvantageProps> = ({\n    numerator,\n    denominator,\n    generationTime,\n    views,\n}) => {\n    const lapis = useContext(LapisUrlContext);\n    const [yAxisScaleType, setYAxisScaleType] = useState<ScaleType>('linear');\n\n    const { data, error, isLoading } = useQuery(\n        () => queryRelativeGrowthAdvantage(numerator, denominator, generationTime, lapis),\n        [lapis, numerator, denominator, generationTime, views],\n    );\n\n    const headline = 'Relative growth advantage';\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <RelativeGrowthAdvantageTabs\n                data={data}\n                yAxisScaleType={yAxisScaleType}\n                setYAxisScaleType={setYAxisScaleType}\n                views={views}\n            />\n        </Headline>\n    );\n};\n\ntype RelativeGrowthAdvantageTabsProps = {\n    data: NonNullable<RelativeGrowthAdvantageData>;\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    views: View[];\n};\n\nconst RelativeGrowthAdvantageTabs: FunctionComponent<RelativeGrowthAdvantageTabsProps> = ({\n    data,\n    yAxisScaleType,\n    setYAxisScaleType,\n    views,\n}) => {\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'line':\n                return {\n                    title: 'Line',\n                    content: (\n                        <RelativeGrowthAdvantageChart\n                            data={{\n                                ...data.estimatedProportions,\n                                observed: data.observedProportions,\n                                params: data.params,\n                            }}\n                            yAxisScaleType={yAxisScaleType}\n                        />\n                    ),\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n    const toolbar = () => (\n        <RelativeGrowthAdvantageToolbar yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype RelativeGrowthAdvantageToolbarProps = {\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n};\n\nconst RelativeGrowthAdvantageToolbar: FunctionComponent<RelativeGrowthAdvantageToolbarProps> = ({\n    yAxisScaleType,\n    setYAxisScaleType,\n}) => {\n    return (\n        <div class='flex'>\n            <ScalingSelector yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n            <Info className='ml-1' content='Line chart' />\n        </div>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { RelativeGrowthAdvantage, type View } from '../../preact/relativeGrowthAdvantage/relative-growth-advantage';\nimport type { LapisFilter } from '../../types';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n@customElement('gs-relative-growth-advantage')\nexport class RelativeGrowthAdvantageComponent extends PreactLitAdapter {\n    @property({ type: Object })\n    numerator: LapisFilter = {};\n\n    @property({ type: Object })\n    denominator: LapisFilter = {};\n\n    @property({ type: Number })\n    generationTime: number = 7;\n\n    @property({ type: Array })\n    views: View[] = ['line'];\n\n    override render() {\n        return (\n            <RelativeGrowthAdvantage\n                numerator={this.numerator}\n                denominator={this.denominator}\n                generationTime={this.generationTime}\n                views={this.views}\n            />\n        );\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-relative-growth-advantage': RelativeGrowthAdvantageComponent;\n    }\n}\n","export const toYYYYMMDD = (date?: Date) => {\n    if (!date) {\n        return undefined;\n    }\n\n    const options: Intl.DateTimeFormatOptions = { year: 'numeric', month: '2-digit', day: '2-digit' };\n    return date.toLocaleDateString('en-CA', options);\n};\n","import flatpickr from 'flatpickr';\nimport { type FunctionComponent } from 'preact';\nimport 'flatpickr/dist/flatpickr.min.css';\nimport { useEffect, useRef, useState } from 'preact/hooks';\n\nimport { toYYYYMMDD } from './dateConversion';\nimport { Select } from '../components/select';\nimport type { ScaleType } from '../shared/charts/getYAxisScale';\n\nexport type CustomSelectOption = { label: string; dateFrom: string; dateTo: string };\n\nexport interface DateRangeSelectorProps {\n    customSelectOptions: CustomSelectOption[];\n    earliestDate?: string;\n}\n\nexport const DateRangeSelector: FunctionComponent<DateRangeSelectorProps> = ({\n    customSelectOptions,\n    earliestDate = '1900-01-01',\n}) => {\n    const datePickerRef = useRef<HTMLInputElement>(null);\n    const endDatePickerRef = useRef<HTMLInputElement>(null);\n    const divRef = useRef<HTMLDivElement>(null);\n    const [dateFromPicker, setDateFromPicker] = useState<flatpickr.Instance | null>(null);\n    const [dateToPicker, setDateToPicker] = useState<flatpickr.Instance | null>(null);\n\n    const [selectedDateRange, setSelectedDateRange] = useState('last6Months');\n    const [selectedDates, setSelectedDates] = useState<{ dateFrom: Date; dateTo: Date }>({\n        dateFrom: getDatesForSelectorValue('last6Months', customSelectOptions, earliestDate).dateFrom,\n        dateTo: getDatesForSelectorValue('last6Months', customSelectOptions, earliestDate).dateTo,\n    });\n\n    useEffect(() => {\n        const commonConfig = {\n            allowInput: true,\n            dateFormat: 'Y-m-d',\n        };\n\n        if (datePickerRef.current) {\n            setDateFromPicker(\n                flatpickr(datePickerRef.current, {\n                    ...commonConfig,\n                    defaultDate: selectedDates.dateFrom,\n                }),\n            );\n        }\n\n        if (endDatePickerRef.current) {\n            setDateToPicker(\n                flatpickr(endDatePickerRef.current, {\n                    ...commonConfig,\n                    defaultDate: selectedDates.dateTo,\n                }),\n            );\n        }\n\n        return () => {\n            dateFromPicker?.destroy();\n            dateToPicker?.destroy();\n        };\n        // eslint-disable-next-line react-hooks/exhaustive-deps\n    }, [datePickerRef, endDatePickerRef]);\n\n    const selectableOptions = () => {\n        const presetOptions = [\n            { label: 'Custom', value: 'custom' },\n            { label: 'All times', value: 'allTimes' },\n            { label: 'Last 2 weeks', value: 'last2Weeks' },\n            { label: 'Last month', value: 'lastMonth' },\n            { label: 'Last 2 weeks', value: 'last2Weeks' },\n            { label: 'Last month', value: 'lastMonth' },\n            { label: 'Last 2 months', value: 'last2Months' },\n            { label: 'Last 3 months', value: 'last3Months' },\n            { label: 'Last 6 months', value: 'last6Months' },\n        ];\n\n        const customOptions = customSelectOptions.map((customSelectOption) => {\n            return { label: customSelectOption.label, value: customLabelToOptionValue(customSelectOption.label) };\n        });\n\n        return [...presetOptions, ...customOptions];\n    };\n\n    const onSelectChange = (value: string) => {\n        setSelectedDateRange(value);\n\n        const dateRange = getDatesForSelectorValue(value, customSelectOptions, earliestDate);\n\n        dateToPicker?.set('minDate', dateRange.dateFrom);\n        dateFromPicker?.set('maxDate', dateRange.dateTo);\n\n        dateFromPicker?.setDate(dateRange.dateFrom);\n        dateToPicker?.setDate(dateRange.dateTo);\n\n        setSelectedDates({\n            dateFrom: dateRange.dateFrom,\n            dateTo: dateRange.dateTo,\n        });\n\n        submit();\n    };\n\n    const onChangeDateFrom = () => {\n        if (selectedDates.dateFrom.toDateString() === dateFromPicker?.selectedDates[0].toDateString()) {\n            return;\n        }\n\n        selectedDates.dateFrom = dateFromPicker?.selectedDates[0] || new Date();\n        dateToPicker?.set('minDate', dateFromPicker?.selectedDates[0]);\n        setSelectedDateRange('custom');\n\n        submit();\n    };\n\n    const onChangeDateTo = () => {\n        if (selectedDates.dateTo.toDateString() === dateToPicker?.selectedDates[0].toDateString()) {\n            return;\n        }\n\n        selectedDates.dateTo = dateToPicker?.selectedDates[0] || new Date();\n        dateFromPicker?.set('maxDate', dateToPicker?.selectedDates[0]);\n        setSelectedDateRange('custom');\n\n        submit();\n    };\n\n    const submit = () => {\n        const dateFrom = toYYYYMMDD(dateFromPicker?.selectedDates[0]);\n        const dateTo = toYYYYMMDD(dateToPicker?.selectedDates[0]);\n\n        const detail = {\n            ...(dateFrom !== undefined && { dateFrom }),\n            ...(dateTo !== undefined && { dateTo }),\n        };\n\n        divRef.current?.dispatchEvent(\n            new CustomEvent('gs-date-range-changed', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    return (\n        <div class='join' ref={divRef}>\n            <Select\n                items={selectableOptions()}\n                selected={selectedDateRange}\n                selectStyle='select-bordered rounded-none join-item'\n                onChange={(event: Event) => {\n                    event.preventDefault();\n                    const select = event.target as HTMLSelectElement;\n                    const value = select.value as ScaleType;\n                    onSelectChange(value);\n                }}\n            />\n            <input\n                class='input input-bordered rounded-none join-item'\n                type='text'\n                placeholder='Date from'\n                ref={datePickerRef}\n                onChange={onChangeDateFrom}\n                onBlur={onChangeDateFrom}\n            />\n            <input\n                class='input input-bordered rounded-none join-item'\n                type='text'\n                placeholder='Date to'\n                ref={endDatePickerRef}\n                onChange={onChangeDateTo}\n                onBlur={onChangeDateFrom}\n            />\n        </div>\n    );\n};\n\nconst customLabelToOptionValue = (customLabel: string) => {\n    return `${customLabel}customLabel`;\n};\n\nconst getDatesForSelectorValue = (\n    selectorValue: string,\n    customSelectOptions: CustomSelectOption[],\n    earliestDate: string,\n) => {\n    const today = new Date();\n\n    const customSelectOption = customSelectOptions.find(\n        (option) => customLabelToOptionValue(option.label) === selectorValue,\n    );\n    if (customSelectOption) {\n        return { dateFrom: new Date(customSelectOption.dateFrom), dateTo: new Date(customSelectOption.dateTo) };\n    }\n\n    switch (selectorValue) {\n        case 'last2Weeks': {\n            const twoWeeksAgo = new Date(today);\n            twoWeeksAgo.setDate(today.getDate() - 14);\n            return { dateFrom: twoWeeksAgo, dateTo: today };\n        }\n        case 'lastMonth': {\n            const lastMonth = new Date(today);\n            lastMonth.setMonth(today.getMonth() - 1);\n            return { dateFrom: lastMonth, dateTo: today };\n        }\n        case 'last2Months': {\n            const twoMonthsAgo = new Date(today);\n            twoMonthsAgo.setMonth(today.getMonth() - 2);\n            return { dateFrom: twoMonthsAgo, dateTo: today };\n        }\n        case 'last3Months': {\n            const threeMonthsAgo = new Date(today);\n            threeMonthsAgo.setMonth(today.getMonth() - 3);\n            return { dateFrom: threeMonthsAgo, dateTo: today };\n        }\n        case 'last6Months': {\n            const sixMonthsAgo = new Date(today);\n            sixMonthsAgo.setMonth(today.getMonth() - 6);\n            return { dateFrom: sixMonthsAgo, dateTo: today };\n        }\n        case 'allTimes': {\n            return { dateFrom: new Date(earliestDate), dateTo: today };\n        }\n        default:\n            return { dateFrom: today, dateTo: today };\n    }\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { type CustomSelectOption, DateRangeSelector } from '../../preact/dateRangeSelector/date-range-selector';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * @fires {CustomEvent<{ dateFrom: string; dateTo: string; }>} gs-date-range-changed - When the date range has changed\n */\n@customElement('gs-date-range-selector')\nexport class DateRangeSelectorComponent extends PreactLitAdapter {\n    @property({ type: Array })\n    customSelectOptions: CustomSelectOption[] = [];\n\n    @property({ type: String })\n    earliestDate: string | undefined = '1900-01-01';\n\n    override render() {\n        return <DateRangeSelector customSelectOptions={this.customSelectOptions} earliestDate={this.earliestDate} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-date-range-selector': DateRangeSelectorComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-date-range-changed': CustomEvent<{\n            dateFrom: string;\n            dateTo: string;\n        }>;\n    }\n}\n","import { FetchAggregatedOperator } from '../../operator/FetchAggregatedOperator';\n\nexport async function fetchAutocompletionList(fields: string[], lapis: string, signal?: AbortSignal) {\n    const toAncestorInHierarchyOverwriteValues = Array(fields.length - 1)\n        .fill(0)\n        .map((_, i) => i + 1)\n        .map((i) => fields.slice(i).reduce((acc, field) => ({ ...acc, [field]: null }), {}));\n\n    const fetchAggregatedOperator = new FetchAggregatedOperator<Record<string, string | null>>({}, fields);\n\n    const data = (await fetchAggregatedOperator.evaluate(lapis, signal)).content;\n    const locationValues = data\n        .map((entry) => fields.reduce((acc, field) => ({ ...acc, [field]: entry[field] }), {}))\n        .reduce<Set<string>>((setOfAllHierarchies, entry) => {\n            setOfAllHierarchies.add(JSON.stringify(entry));\n            toAncestorInHierarchyOverwriteValues.forEach((overwriteValues) => {\n                setOfAllHierarchies.add(JSON.stringify({ ...entry, ...overwriteValues }));\n            });\n            return setOfAllHierarchies;\n        }, new Set());\n\n    return [...locationValues].map((json) => JSON.parse(json)).sort(compareLocationEntries(fields));\n}\n\nfunction compareLocationEntries(fields: string[]) {\n    return (a: Record<string, string | null>, b: Record<string, string | null>) => {\n        for (const field of fields) {\n            const valueA = a[field];\n            const valueB = b[field];\n            if (valueA === valueB) {\n                continue;\n            }\n            if (valueA === null) {\n                return -1;\n            }\n            if (valueB === null) {\n                return 1;\n            }\n            return valueA < valueB ? -1 : 1;\n        }\n        return 0;\n    };\n}\n","import { useContext, useRef, useState } from 'preact/hooks';\n\nimport { fetchAutocompletionList } from './fetchAutocompletionList';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { useQuery } from '../useQuery';\n\nexport type LocationFilterProps = {\n    value?: string;\n    fields: string[];\n};\n\nexport const LocationFilter = ({ value: initialValue, fields }: LocationFilterProps) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const [value, setValue] = useState(initialValue ?? '');\n    const [unknownLocation, setUnknownLocation] = useState(false);\n\n    const formRef = useRef<HTMLFormElement>(null);\n\n    const { data, error, isLoading } = useQuery(() => fetchAutocompletionList(fields, lapis), [fields, lapis]);\n\n    if (isLoading)\n        return (\n            <form class='flex'>\n                <input type='text' class='input input-bordered grow' value={value} disabled />\n                <button class='btn ml-1' disabled type='submit'>\n                    Loading...\n                </button>\n            </form>\n        );\n\n    if (error) {\n        return (\n            <p>\n                Error: {error.name} {error.message} {error.stack}\n            </p>\n        );\n    }\n\n    const onInput = (event: InputEvent) => {\n        if (event.target instanceof HTMLInputElement) {\n            const inputValue = event.target.value;\n            setValue(inputValue);\n            if (unknownLocation) {\n                const eventDetail = parseLocation(inputValue, fields);\n                if (hasMatchingEntry(data, eventDetail)) {\n                    setUnknownLocation(false);\n                }\n            }\n        }\n    };\n\n    const submit = (event: SubmitEvent) => {\n        event.preventDefault();\n        const eventDetail = parseLocation(value, fields);\n\n        if (hasMatchingEntry(data, eventDetail)) {\n            setUnknownLocation(false);\n\n            formRef.current?.dispatchEvent(\n                new CustomEvent('gs-location-changed', {\n                    detail: eventDetail,\n                    bubbles: true,\n                    composed: true,\n                }),\n            );\n        } else {\n            setUnknownLocation(true);\n        }\n    };\n\n    return (\n        <form class='flex' onSubmit={submit} ref={formRef}>\n            <input\n                type='text'\n                class={`input input-bordered grow ${unknownLocation ? 'border-2 border-error' : ''}`}\n                value={value}\n                onInput={onInput}\n                list='countries'\n            />\n            <datalist id='countries'>\n                {data?.map((v) => {\n                    const value = fields\n                        .map((field) => v[field])\n                        .filter((value) => value !== null)\n                        .join(' / ');\n                    return <option key={value} value={value} />;\n                })}\n            </datalist>\n            <button class='btn btn-primary ml-1' type='submit'>\n                Submit\n            </button>\n        </form>\n    );\n};\n\nconst parseLocation = (location: string, fields: string[]) => {\n    const fieldValues = location.split('/').map((part) => part.trim());\n    return fieldValues.reduce((acc, fieldValue, i) => ({ ...acc, [fields[i]]: fieldValue }), {});\n};\n\nconst hasMatchingEntry = (data: Record<string, string>[] | null, eventDetail: Record<string, string>) => {\n    if (data === null) {\n        return false;\n    }\n\n    const matchingEntries = Object.entries(eventDetail)\n        .filter(([, value]) => value !== undefined)\n        .reduce((filteredData, [key, value]) => filteredData.filter((it) => it[key] === value), data);\n\n    return matchingEntries.length > 0;\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { LocationFilter } from '../../preact/locationFilter/location-filter';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * ## Tag\n *\n * `gs-location-filter`\n *\n * ## Context\n *\n * This component provides an input field to specify filters for locations.\n *\n * It expects a list of fields that form a strict hierarchical order, such as continent, country, and city.\n * The component retrieves a list of all possible values for these fields from the Lapis instance.\n * This list is then utilized to display autocomplete suggestions and to validate the input.\n *\n * Given `fields` are `['field1', 'field2', ..., 'fieldN']`,\n * then valid values for the location filter must be in the form `valueForField1 / valueForField2 / ... / valueForFieldK`,\n * where `1 <= K <= N`.\n * Values for the fields `i > K` are considered `undefined`.\n *\n * @fires {CustomEvent<Record<string, string>>} gs-location-changed\n * Fired when the field is submitted with a valid location value.\n * The `details` of this event contain an object with all `fields` as keys\n * and the corresponding values as values, if they are not `undefined`.\n * Example:\n * ```\n * {\n *   continent: \"Asia\",\n *   country: \"China\",\n *   city: \"Beijing\"\n * }\n * ```\n */\n@customElement('gs-location-filter')\nexport class LocationFilterComponent extends PreactLitAdapter {\n    /**\n     * The initial value to use for this location filter.\n     * Must be of the form `valueForField1 / valueForField2 / ... / valueForFieldN`.\n     */\n    @property()\n    value = '';\n\n    /**\n     * The fields to display in the location filter, in hierarchical order.\n     * The top-level field should be the first entry in the array.\n     * This component assumes that the values for each field form a strict hierarchy\n     * (e.g., `fields = ['continent', 'country', 'city']`).\n     */\n    @property({ type: Array })\n    fields: string[] = [];\n\n    override render() {\n        return <LocationFilter value={this.value} fields={this.fields} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-location-filter': LocationFilterComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-location-changed': CustomEvent<Record<string, string>>;\n    }\n}\n","import { FetchAggregatedOperator } from '../../operator/FetchAggregatedOperator';\n\nexport async function fetchAutocompleteList(lapis: string, field: string, signal?: AbortSignal) {\n    const fetchAggregatedOperator = new FetchAggregatedOperator<Record<string, string>>({}, [field]);\n\n    const data = (await fetchAggregatedOperator.evaluate(lapis, signal)).content;\n\n    return data.map((item) => item[field]);\n}\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useRef } from 'preact/hooks';\n\nimport { fetchAutocompleteList } from './fetchAutocompleteList';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ErrorDisplay } from '../components/error-display';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { useQuery } from '../useQuery';\n\nexport interface TextInputProps {\n    lapisField: string;\n    placeholderText?: string;\n}\n\nexport const TextInput: FunctionComponent<TextInputProps> = ({ lapisField, placeholderText }) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const inputRef = useRef<HTMLInputElement>(null);\n\n    const { data, error, isLoading } = useQuery(() => fetchAutocompleteList(lapis, lapisField), [lapisField, lapis]);\n\n    if (isLoading) {\n        return <LoadingDisplay />;\n    }\n\n    if (error !== null) {\n        return <ErrorDisplay error={error} />;\n    }\n\n    if (data === null) {\n        return <NoDataDisplay />;\n    }\n\n    const onInput = () => {\n        const value = inputRef.current?.value;\n\n        if (isValidValue(value)) {\n            inputRef.current?.dispatchEvent(\n                new CustomEvent('gs-text-input-changed', {\n                    detail: { [lapisField]: value },\n                    bubbles: true,\n                    composed: true,\n                }),\n            );\n        }\n    };\n\n    const isValidValue = (value: string | undefined) => {\n        if (value === undefined) {\n            return false;\n        }\n        return data.includes(value);\n    };\n\n    return (\n        <>\n            <input\n                type='text'\n                class='input input-bordered'\n                placeholder={placeholderText !== undefined ? placeholderText : lapisField}\n                onInput={onInput}\n                ref={inputRef}\n                list={lapisField}\n            />\n            <datalist id={lapisField}>\n                {data.map((item) => (\n                    <option value={item} key={item} />\n                ))}\n            </datalist>\n        </>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { TextInput } from '../../preact/textInput/text-input';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * @fires {CustomEvent<Record<string, string>>} gs-text-input-changed - When the text input has changed\n */\n@customElement('gs-text-input')\nexport class TextInputComponent extends PreactLitAdapter {\n    @property()\n    lapisField = '';\n\n    @property()\n    placeholderText = '';\n\n    override render() {\n        return <TextInput lapisField={this.lapisField} placeholderText={this.placeholderText} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-text-input': TextInputComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-text-input-changed': CustomEvent<Record<string, string>>;\n    }\n}\n","import type { ReferenceGenome } from '../../lapisApi/ReferenceGenome';\nimport type { SequenceType } from '../../types';\n\nexport const sequenceTypeFromSegment = (\n    possibleSegment: string | undefined,\n    referenceGenome: ReferenceGenome,\n): SequenceType | undefined => {\n    if (possibleSegment === undefined) {\n        return referenceGenome.nucleotideSequences.length === 1 ? 'nucleotide' : undefined;\n    }\n\n    if (referenceGenome.nucleotideSequences.some((sequence) => sequence.name === possibleSegment)) {\n        return 'nucleotide';\n    }\n\n    if (referenceGenome.genes.some((gene) => gene.name === possibleSegment)) {\n        return 'amino acid';\n    }\n    return undefined;\n};\n","import { type SelectedFilters } from './mutation-filter';\nimport { sequenceTypeFromSegment } from './sequenceTypeFromSegment';\nimport type { ReferenceGenome } from '../../lapisApi/ReferenceGenome';\nimport { Deletion, Insertion, Substitution } from '../../utils/mutations';\n\ntype ParsedMutationFilter = {\n    [MutationType in keyof SelectedFilters]: { type: MutationType; value: SelectedFilters[MutationType][number] };\n}[keyof SelectedFilters];\n\nexport const parseAndValidateMutation = (\n    value: string,\n    referenceGenome: ReferenceGenome,\n): ParsedMutationFilter | null => {\n    const possibleInsertion = Insertion.parse(value);\n    if (possibleInsertion !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleInsertion.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideInsertions', value: possibleInsertion };\n            case 'amino acid':\n                return { type: 'aminoAcidInsertions', value: possibleInsertion };\n            case undefined:\n                return null;\n        }\n    }\n\n    const possibleDeletion = Deletion.parse(value);\n    if (possibleDeletion !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleDeletion.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideMutations', value: possibleDeletion };\n            case 'amino acid':\n                return { type: 'aminoAcidMutations', value: possibleDeletion };\n            case undefined:\n                return null;\n        }\n    }\n\n    const possibleSubstitution = Substitution.parse(value);\n    if (possibleSubstitution !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleSubstitution.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideMutations', value: possibleSubstitution };\n            case 'amino acid':\n                return { type: 'aminoAcidMutations', value: possibleSubstitution };\n            case undefined:\n                return null;\n        }\n    }\n\n    return null;\n};\n","import type { FunctionComponent } from 'preact';\n\nexport const DeleteIcon: FunctionComponent = () => {\n    return (\n        <svg\n            fill='currentColor'\n            stroke-width='0'\n            xmlns='http://www.w3.org/2000/svg'\n            viewBox='0 0 16 16'\n            style='overflow: visible; color: currentcolor;'\n            height='1em'\n            width='1em'\n        >\n            <path d='M4.646 4.646a.5.5 0 0 1 .708 0L8 7.293l2.646-2.647a.5.5 0 0 1 .708.708L8.707 8l2.647 2.646a.5.5 0 0 1-.708.708L8 8.707l-2.646 2.647a.5.5 0 0 1-.708-.708L7.293 8 4.646 5.354a.5.5 0 0 1 0-.708z' />\n        </svg>\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useRef, useState } from 'preact/hooks';\n\nimport { parseAndValidateMutation } from './parseAndValidateMutation';\nimport { type Deletion, type Insertion, type Mutation, type Substitution } from '../../utils/mutations';\nimport { ReferenceGenomeContext } from '../ReferenceGenomeContext';\nimport { singleGraphColorRGBByName } from '../shared/charts/colors';\nimport { DeleteIcon } from '../shared/icons/DeleteIcon';\n\nexport type MutationFilterProps = {};\n\nexport type SelectedFilters = {\n    nucleotideMutations: (Substitution | Deletion)[];\n    aminoAcidMutations: (Substitution | Deletion)[];\n    nucleotideInsertions: Insertion[];\n    aminoAcidInsertions: Insertion[];\n};\n\nexport type SelectedMutationFilterStrings = {\n    [Key in keyof SelectedFilters]: string[];\n};\n\nexport const MutationFilter: FunctionComponent<MutationFilterProps> = () => {\n    const referenceGenome = useContext(ReferenceGenomeContext);\n    const [selectedFilters, setSelectedFilters] = useState<SelectedFilters>({\n        nucleotideMutations: [],\n        aminoAcidMutations: [],\n        nucleotideInsertions: [],\n        aminoAcidInsertions: [],\n    });\n    const [inputValue, setInputValue] = useState('');\n    const [isError, setIsError] = useState(false);\n    const formRef = useRef<HTMLFormElement>(null);\n\n    const handleSubmit = (event: Event) => {\n        event.preventDefault();\n\n        const parsedMutation = parseAndValidateMutation(inputValue, referenceGenome);\n\n        if (parsedMutation === null) {\n            setIsError(true);\n            return;\n        }\n\n        const newSelectedValues = {\n            ...selectedFilters,\n            [parsedMutation.type]: [...selectedFilters[parsedMutation.type], parsedMutation.value],\n        };\n\n        setSelectedFilters(newSelectedValues);\n        fireChangeEvent(newSelectedValues);\n        setInputValue('');\n    };\n\n    const fireChangeEvent = (selectedFilters: SelectedFilters) => {\n        const detail = mapToMutationFilterStrings(selectedFilters);\n\n        formRef.current?.dispatchEvent(\n            new CustomEvent<SelectedMutationFilterStrings>('gs-mutation-filter-changed', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    const handleOnBlur = () => {\n        const detail = mapToMutationFilterStrings(selectedFilters);\n\n        formRef.current?.dispatchEvent(\n            new CustomEvent<SelectedMutationFilterStrings>('gs-mutation-filter-on-blur', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    const handleInputChange = (event: Event) => {\n        setInputValue((event.target as HTMLInputElement).value);\n        setIsError(false);\n    };\n\n    return (\n        <div class={`rounded-lg border border-gray-300 bg-white p-2`}>\n            <SelectedMutationDisplay\n                selectedFilters={selectedFilters}\n                setSelectedFilters={setSelectedFilters}\n                fireChangeEvent={fireChangeEvent}\n            />\n\n            <form className='mt-2 w-full' onSubmit={handleSubmit} ref={formRef}>\n                <label className={`input flex items-center gap-2 ${isError ? 'input-error' : 'input-bordered'}`}>\n                    <input\n                        className='grow min-w-0'\n                        type='text'\n                        value={inputValue}\n                        onInput={handleInputChange}\n                        placeholder={'Enter a mutation'}\n                        onBlur={handleOnBlur}\n                    />\n                    <button className='btn btn-sm'>+</button>\n                </label>\n            </form>\n        </div>\n    );\n};\n\nconst SelectedMutationDisplay: FunctionComponent<{\n    selectedFilters: SelectedFilters;\n    setSelectedFilters: (selectedFilters: SelectedFilters) => void;\n    fireChangeEvent: (selectedFilters: SelectedFilters) => void;\n}> = ({ selectedFilters, setSelectedFilters, fireChangeEvent }) => {\n    const onSelectedRemoved = <MutationType extends keyof SelectedFilters>(\n        mutation: SelectedFilters[MutationType][number],\n        key: MutationType,\n    ) => {\n        const newSelectedValues = {\n            ...selectedFilters,\n            [key]: selectedFilters[key].filter((i) => !mutation.equals(i)),\n        };\n\n        setSelectedFilters(newSelectedValues);\n\n        fireChangeEvent(newSelectedValues);\n    };\n\n    return (\n        <ul class='flex flex-wrap'>\n            {selectedFilters.nucleotideMutations.map((mutation) => (\n                <li key={mutation.toString()}>\n                    <SelectedNucleotideMutation\n                        mutation={mutation}\n                        onDelete={(mutation: Substitution | Deletion) =>\n                            onSelectedRemoved(mutation, 'nucleotideMutations')\n                        }\n                    />\n                </li>\n            ))}\n            {selectedFilters.aminoAcidMutations.map((mutation) => (\n                <li key={mutation.toString()}>\n                    <SelectedAminoAcidMutation\n                        mutation={mutation}\n                        onDelete={(mutation: Substitution | Deletion) =>\n                            onSelectedRemoved(mutation, 'aminoAcidMutations')\n                        }\n                    />\n                </li>\n            ))}\n            {selectedFilters.nucleotideInsertions.map((insertion) => (\n                <li key={insertion.toString()}>\n                    <SelectedNucleotideInsertion\n                        insertion={insertion}\n                        onDelete={(insertion) => onSelectedRemoved(insertion, 'nucleotideInsertions')}\n                    />\n                </li>\n            ))}\n            {selectedFilters.aminoAcidInsertions.map((insertion) => (\n                <li key={insertion.toString()}>\n                    <SelectedAminoAcidInsertion\n                        insertion={insertion}\n                        onDelete={(insertion: Insertion) => onSelectedRemoved(insertion, 'aminoAcidInsertions')}\n                    />\n                </li>\n            ))}\n        </ul>\n    );\n};\n\nconst SelectedAminoAcidInsertion: FunctionComponent<{\n    insertion: Insertion;\n    onDelete: (insertion: Insertion) => void;\n}> = ({ insertion, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('teal', 0.3);\n    const textColor = singleGraphColorRGBByName('teal', 1);\n    return (\n        <SelectedFilter\n            mutation={insertion}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedAminoAcidMutation: FunctionComponent<{\n    mutation: Substitution | Deletion;\n    onDelete: (mutation: Substitution | Deletion) => void;\n}> = ({ mutation, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('rose', 0.3);\n    const textColor = singleGraphColorRGBByName('rose', 1);\n    return (\n        <SelectedFilter\n            mutation={mutation}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedNucleotideMutation: FunctionComponent<{\n    mutation: Substitution | Deletion;\n    onDelete: (insertion: Substitution | Deletion) => void;\n}> = ({ mutation, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('indigo', 0.3);\n    const textColor = singleGraphColorRGBByName('indigo', 1);\n    return (\n        <SelectedFilter\n            mutation={mutation}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedNucleotideInsertion: FunctionComponent<{\n    insertion: Insertion;\n    onDelete: (insertion: Insertion) => void;\n}> = ({ insertion, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('green', 0.3);\n    const textColor = singleGraphColorRGBByName('green', 1);\n\n    return (\n        <SelectedFilter\n            mutation={insertion}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\ntype SelectedFilterProps<MutationType extends Mutation> = {\n    mutation: MutationType;\n    onDelete: (mutation: MutationType) => void;\n    backgroundColor: string;\n    textColor: string;\n};\n\nconst SelectedFilter = <MutationType extends Mutation>({\n    mutation,\n    onDelete,\n    backgroundColor,\n    textColor,\n}: SelectedFilterProps<MutationType>) => {\n    return (\n        <div\n            class='flex items-center flex-nowrap gap-1 rounded me-1 px-2.5 py-0.5 font-medium text-xs mb-1'\n            style={{ backgroundColor, color: textColor }}\n        >\n            <div>{mutation.toString()}</div>\n            <button onClick={() => onDelete(mutation)}>\n                <DeleteIcon />\n            </button>\n        </div>\n    );\n};\n\nfunction mapToMutationFilterStrings(selectedFilters: SelectedFilters) {\n    return {\n        aminoAcidMutations: selectedFilters.aminoAcidMutations.map((mutation) => mutation.toString()),\n        nucleotideMutations: selectedFilters.nucleotideMutations.map((mutation) => mutation.toString()),\n        aminoAcidInsertions: selectedFilters.aminoAcidInsertions.map((insertion) => insertion.toString()),\n        nucleotideInsertions: selectedFilters.nucleotideInsertions.map((insertion) => insertion.toString()),\n    };\n}\n","import { customElement } from 'lit/decorators.js';\n\nimport { type TextInputComponent } from './text-input-component';\nimport { MutationFilter, type SelectedMutationFilterStrings } from '../../preact/mutationFilter/mutation-filter';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * @fires {CustomEvent<SelectedMutationFilterStrings>} gs-mutation-filter-changed - When the mutation filter values have changed\n * @fires {CustomEvent<SelectedMutationFilterStrings>} gs-mutation-filter-on-blur - When the mutation filter has lost focus\n */\n@customElement('gs-mutation-filter')\nexport class MutationFilterComponent extends PreactLitAdapter {\n    override render() {\n        return <MutationFilter />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-mutation-filter': TextInputComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-mutation-filter-changed': CustomEvent<SelectedMutationFilterStrings>;\n        'gs-mutation-filter-on-blur': CustomEvent<SelectedMutationFilterStrings>;\n    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Use 'unsafeCSS' to pass non-literal values, but take care to ensure page security.\")})(s)+t[o+1]),t[0]);return new n(o,t,s)},S=(s,o)=>{if(e)s.adoptedStyleSheets=o.map((t=>t instanceof CSSStyleSheet?t:t.styleSheet));else for(const e of o){const o=document.createElement(\"style\"),n=t.litNonce;void 0!==n&&o.setAttribute(\"nonce\",n),o.textContent=e.cssText,s.appendChild(o)}},c=e?t=>t:t=>t instanceof CSSStyleSheet?(t=>{let e=\"\";for(const s of t.cssRules)e+=s.cssText;return r(e)})(t):t;export{n as CSSResult,S as adoptStyles,i as css,c as getCompatibleStyle,e as supportsAdoptingStyleSheets,r as unsafeCSS};\n//# sourceMappingURL=css-tag.js.map\n","import{getCompatibleStyle as t,adoptStyles as s}from\"./css-tag.js\";export{CSSResult,adoptStyles,css,getCompatibleStyle,supportsAdoptingStyleSheets,unsafeCSS}from\"./css-tag.js\";\n/**\n * @license\n * Copyright 2017 Google LLC\n * SPDX-License-Identifier: BSD-3-Clause\n 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i=Symbol(),r=this.getPropertyDescriptor(t,i,s);void 0!==r&&e(this.prototype,t,r)}}static getPropertyDescriptor(t,s,i){const{get:e,set:h}=r(this.prototype,t)??{get(){return this[s]},set(t){this[s]=t}};return{get(){return e?.call(this)},set(s){const r=e?.call(this);h.call(this,s),this.requestUpdate(t,r,i)},configurable:!0,enumerable:!0}}static getPropertyOptions(t){return this.elementProperties.get(t)??y}static _$Ei(){if(this.hasOwnProperty(d(\"elementProperties\")))return;const t=n(this);t.finalize(),void 0!==t.l&&(this.l=[...t.l]),this.elementProperties=new Map(t.elementProperties)}static finalize(){if(this.hasOwnProperty(d(\"finalized\")))return;if(this.finalized=!0,this._$Ei(),this.hasOwnProperty(d(\"properties\"))){const t=this.properties,s=[...h(t),...o(t)];for(const i of s)this.createProperty(i,t[i])}const t=this[Symbol.metadata];if(null!==t){const s=litPropertyMetadata.get(t);if(void 0!==s)for(const[t,i]of s)this.elementProperties.set(t,i)}this._$Eh=new Map;for(const[t,s]of 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this[i]);t.size>0&&(this._$Ep=t)}createRenderRoot(){const t=this.shadowRoot??this.attachShadow(this.constructor.shadowRootOptions);return s(t,this.constructor.elementStyles),t}connectedCallback(){this.renderRoot??=this.createRenderRoot(),this.enableUpdating(!0),this._$EO?.forEach((t=>t.hostConnected?.()))}enableUpdating(t){}disconnectedCallback(){this._$EO?.forEach((t=>t.hostDisconnected?.()))}attributeChangedCallback(t,s,i){this._$AK(t,i)}_$EC(t,s){const i=this.constructor.elementProperties.get(t),e=this.constructor._$Eu(t,i);if(void 0!==e&&!0===i.reflect){const r=(void 0!==i.converter?.toAttribute?i.converter:u).toAttribute(s,i.type);this._$Em=t,null==r?this.removeAttribute(e):this.setAttribute(e,r),this._$Em=null}}_$AK(t,s){const i=this.constructor,e=i._$Eh.get(t);if(void 0!==e&&this._$Em!==e){const t=i.getPropertyOptions(e),r=\"function\"==typeof t.converter?{fromAttribute:t.converter}:void 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s=this._$AL;try{t=this.shouldUpdate(s),t?(this.willUpdate(s),this._$EO?.forEach((t=>t.hostUpdate?.())),this.update(s)):this._$EU()}catch(s){throw t=!1,this._$EU(),s}t&&this._$AE(s)}willUpdate(t){}_$AE(t){this._$EO?.forEach((t=>t.hostUpdated?.())),this.hasUpdated||(this.hasUpdated=!0,this.firstUpdated(t)),this.updated(t)}_$EU(){this._$AL=new Map,this.isUpdatePending=!1}get updateComplete(){return this.getUpdateComplete()}getUpdateComplete(){return this._$ES}shouldUpdate(t){return!0}update(t){this._$Ej&&=this._$Ej.forEach((t=>this._$EC(t,this[t]))),this._$EU()}updated(t){}firstUpdated(t){}}b.elementStyles=[],b.shadowRootOptions={mode:\"open\"},b[d(\"elementProperties\")]=new Map,b[d(\"finalized\")]=new Map,p?.({ReactiveElement:b}),(a.reactiveElementVersions??=[]).push(\"2.0.4\");export{b as ReactiveElement,u as defaultConverter,f as notEqual};\n//# sourceMappingURL=reactive-element.js.map\n","import{defaultConverter as t,notEqual as e}from\"../reactive-element.js\";\n/**\n * @license\n * Copyright 2017 Google LLC\n * SPDX-License-Identifier: BSD-3-Clause\n */const o={attribute:!0,type:String,converter:t,reflect:!1,hasChanged:e},r=(t=o,e,r)=>{const{kind:n,metadata:i}=r;let s=globalThis.litPropertyMetadata.get(i);if(void 0===s&&globalThis.litPropertyMetadata.set(i,s=new Map),s.set(r.name,t),\"accessor\"===n){const{name:o}=r;return{set(r){const n=e.get.call(this);e.set.call(this,r),this.requestUpdate(o,n,t)},init(e){return void 0!==e&&this.P(o,void 0,t),e}}}if(\"setter\"===n){const{name:o}=r;return function(r){const n=this[o];e.call(this,r),this.requestUpdate(o,n,t)}}throw Error(\"Unsupported decorator location: \"+n)};function n(t){return(e,o)=>\"object\"==typeof o?r(t,e,o):((t,e,o)=>{const r=e.hasOwnProperty(o);return e.constructor.createProperty(o,r?{...t,wrapped:!0}:t),r?Object.getOwnPropertyDescriptor(e,o):void 0})(t,e,o)}export{n as property,r as standardProperty};\n//# sourceMappingURL=property.js.map\n","import { createContext } from '@lit/context';\n\nexport const lapisContext = createContext<string>('lapis-context');\n","import { createContext } from '@lit/context';\n\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\n\nexport const referenceGenomeContext = createContext<ReferenceGenome>('reference-genome-context');\n","import z from 'zod';\n\nimport type { SequenceType } from '../types';\n\nexport const referenceGenomeResponse = z.object({\n    nucleotideSequences: z.array(\n        z.object({\n            name: z.string(),\n            sequence: z.string(),\n        }),\n    ),\n    genes: z.array(\n        z.object({\n            name: z.string(),\n            sequence: z.string(),\n        }),\n    ),\n});\nexport type ReferenceGenome = z.infer<typeof referenceGenomeResponse>;\n\nexport const getSegmentNames = (referenceGenome: ReferenceGenome, sequenceType: SequenceType) => {\n    switch (sequenceType) {\n        case 'nucleotide': {\n            return referenceGenome.nucleotideSequences.map((sequence) => sequence.name);\n        }\n        case 'amino acid': {\n            return referenceGenome.genes.map((gene) => gene.name);\n        }\n    }\n};\n","import z, { type ZodTypeAny } from 'zod';\n\nexport const orderByType = z.enum(['ascending', 'descending']);\n\nexport const orderBy = z.object({\n    field: z.string(),\n    type: orderByType,\n});\n\nexport const lapisBaseRequest = z\n    .object({\n        limit: z.number().optional(),\n        offset: z.number().optional(),\n        fields: z.array(z.string()).optional(),\n        orderBy: z.array(orderBy).optional(),\n    })\n    .catchall(z.union([z.boolean(), z.undefined(), z.string(), z.number(), z.null(), z.array(z.string())]));\nexport type LapisBaseRequest = z.infer<typeof lapisBaseRequest>;\n\nexport const mutationsRequest = lapisBaseRequest.extend({ minProportion: z.number().optional() });\nexport type MutationsRequest = z.infer<typeof mutationsRequest>;\n\nconst mutationProportionCount = z.object({\n    mutation: z.string(),\n    proportion: z.number(),\n    count: z.number(),\n    sequenceName: z.union([z.string(), z.null()]),\n    mutationFrom: z.string(),\n    mutationTo: z.string(),\n    position: z.number(),\n});\nexport const mutationsResponse = makeLapisResponse(z.array(mutationProportionCount));\n\nconst insertionCount = z.object({\n    insertion: z.string(),\n    count: z.number(),\n    insertedSymbols: z.string(),\n    position: z.number(),\n    sequenceName: z.union([z.string(), z.null()]),\n});\nexport const insertionsResponse = makeLapisResponse(z.array(insertionCount));\n\nexport const aggregatedItem = z.object({ count: z.number() }).catchall(z.union([z.string(), z.number(), z.null()]));\nexport const aggregatedResponse = makeLapisResponse(z.array(aggregatedItem));\nexport type AggregatedItem = z.infer<typeof aggregatedItem>;\n\nfunction makeLapisResponse<T extends ZodTypeAny>(data: T) {\n    return z.object({\n        data,\n    });\n}\n","import { referenceGenomeResponse } from './ReferenceGenome';\nimport {\n    aggregatedResponse,\n    insertionsResponse,\n    type LapisBaseRequest,\n    type MutationsRequest,\n    mutationsResponse,\n} from './lapisTypes';\nimport { type SequenceType } from '../types';\n\nexport async function fetchAggregated(lapisUrl: string, body: LapisBaseRequest, signal?: AbortSignal) {\n    const response = await fetch(aggregatedEndpoint(lapisUrl), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return aggregatedResponse.parse(await response.json());\n}\n\nexport async function fetchInsertions(\n    lapisUrl: string,\n    body: LapisBaseRequest,\n    sequenceType: SequenceType,\n    signal?: AbortSignal,\n) {\n    const response = await fetch(insertionsEndpoint(lapisUrl, sequenceType), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return insertionsResponse.parse(await response.json());\n}\n\nexport async function fetchSubstitutionsOrDeletions(\n    lapisUrl: string,\n    body: MutationsRequest,\n    sequenceType: SequenceType,\n    signal?: AbortSignal,\n) {\n    const response = await fetch(substitutionsOrDeletionsEndpoint(lapisUrl, sequenceType), {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(body),\n        signal,\n    });\n\n    await handleErrors(response);\n\n    return mutationsResponse.parse(await response.json());\n}\n\nexport async function fetchReferenceGenome(lapisUrl: string, signal?: AbortSignal) {\n    const response = await fetch(referenceGenomeEndpoint(lapisUrl), {\n        method: 'GET',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        signal,\n    });\n\n    await handleErrors(response);\n    return referenceGenomeResponse.parse(await response.json());\n}\n\nconst handleErrors = async (response: Response) => {\n    if (!response.ok) {\n        if (response.status >= 400 && response.status < 500) {\n            throw new Error(`${response.statusText}: ${JSON.stringify(await response.json())}`);\n        }\n        throw new Error(`${response.statusText}: ${response.status}`);\n    }\n};\n\nexport const aggregatedEndpoint = (lapisUrl: string) => `${lapisUrl}/sample/aggregated`;\nexport const insertionsEndpoint = (lapisUrl: string, sequenceType: SequenceType) => {\n    return sequenceType === 'amino acid'\n        ? `${lapisUrl}/sample/aminoAcidInsertions`\n        : `${lapisUrl}/sample/nucleotideInsertions`;\n};\nexport const substitutionsOrDeletionsEndpoint = (lapisUrl: string, sequenceType: SequenceType) => {\n    return sequenceType === 'amino acid'\n        ? `${lapisUrl}/sample/aminoAcidMutations`\n        : `${lapisUrl}/sample/nucleotideMutations`;\n};\nexport const referenceGenomeEndpoint = (lapisUrl: string) => `${lapisUrl}/sample/referenceGenome`;\n","import { provide } from '@lit/context';\nimport { Task } from '@lit/task';\nimport { html, LitElement } from 'lit';\nimport { customElement, property } from 'lit/decorators.js';\n\nimport { lapisContext } from './lapis-context';\nimport { referenceGenomeContext } from './reference-genome-context';\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\nimport { fetchReferenceGenome } from '../lapisApi/lapisApi';\n\n@customElement('gs-app')\nexport class App extends LitElement {\n    @provide({ context: lapisContext })\n    @property()\n    lapis: string = '';\n\n    @provide({ context: referenceGenomeContext })\n    referenceGenome: ReferenceGenome = {\n        nucleotideSequences: [],\n        genes: [],\n    };\n\n    private updateReferenceGenome = new Task(this, {\n        task: async () => {\n            this.referenceGenome = await fetchReferenceGenome(this.lapis);\n        },\n        args: () => [this.lapis],\n    });\n\n    override render() {\n        return this.updateReferenceGenome.render({\n            complete: () => {\n                return html` <slot></slot>`;\n            },\n            error: () => html`<p>Error</p>`, // TODO(#143): Add more advanced error handling\n            pending: () => {\n                return html`<p>Loading...</p>`;\n            },\n        });\n    }\n\n    override createRenderRoot() {\n        return this;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-app': App;\n    }\n}\n","import{options as r,Fragment as e}from\"preact\";export{Fragment}from\"preact\";var t=/[\"&<]/;function n(r){if(0===r.length||!1===t.test(r))return r;for(var e=0,n=0,o=\"\",f=\"\";n<r.length;n++){switch(r.charCodeAt(n)){case 34:f=\"&quot;\";break;case 38:f=\"&amp;\";break;case 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i=(r=n.__c).__H;i&&(u===r?(i.__h=[],r.__h=[],i.__.forEach(function(n){n.__N&&(n.__=n.__N),n.__V=c,n.__N=n.i=void 0})):(i.__h.forEach(z),i.__h.forEach(B),i.__h=[],t=0)),u=r},e.diffed=function(n){l&&l(n);var t=n.__c;t&&t.__H&&(t.__H.__h.length&&(1!==f.push(t)&&i===e.requestAnimationFrame||((i=e.requestAnimationFrame)||w)(j)),t.__H.__.forEach(function(n){n.i&&(n.__H=n.i),n.__V!==c&&(n.__=n.__V),n.i=void 0,n.__V=c})),u=r=null},e.__c=function(n,t){t.some(function(n){try{n.__h.forEach(z),n.__h=n.__h.filter(function(n){return!n.__||B(n)})}catch(r){t.some(function(n){n.__h&&(n.__h=[])}),t=[],e.__e(r,n.__v)}}),m&&m(n,t)},e.unmount=function(n){s&&s(n);var t,r=n.__c;r&&r.__H&&(r.__H.__.forEach(function(n){try{z(n)}catch(n){t=n}}),r.__H=void 0,t&&e.__e(t,r.__v))};var k=\"function\"==typeof requestAnimationFrame;function w(n){var t,r=function(){clearTimeout(u),k&&cancelAnimationFrame(t),setTimeout(n)},u=setTimeout(r,100);k&&(t=requestAnimationFrame(r))}function z(n){var t=r,u=n.__c;\"function\"==typeof u&&(n.__c=void 0,u()),r=t}function B(n){var t=r;n.__c=n.__(),r=t}function C(n,t){return!n||n.length!==t.length||t.some(function(t,r){return t!==n[r]})}function D(n,t){return\"function\"==typeof t?t(n):t}export{x as useCallback,P as useContext,V as useDebugValue,_ as useEffect,b as useErrorBoundary,g as useId,T as useImperativeHandle,A as useLayoutEffect,q as useMemo,y as useReducer,F as useRef,p as useState};\n//# sourceMappingURL=hooks.module.js.map\n","import { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\ntype Proportions = {\n    [displayName: string]: number;\n};\n\nexport function getMutationComparisonTableData(data: Dataset<MutationData>, proportionInterval: ProportionInterval) {\n    const mutationsToProportions = new Map<string, Proportions>();\n\n    for (const mutationData of data.content) {\n        for (const mutationEntry of mutationData.data) {\n            const mutation = mutationEntry.mutation.toString();\n            const proportions = mutationsToProportions.get(mutation) || {};\n            proportions[mutationData.displayName] = mutationEntry.proportion;\n            mutationsToProportions.set(mutation, proportions);\n        }\n    }\n\n    return [...mutationsToProportions.entries()]\n        .map(([mutation, proportions]) => {\n            return {\n                mutation,\n                ...data.content\n                    .map((mutationData) => {\n                        return {\n                            [`${mutationData.displayName} prevalence`]: proportions[mutationData.displayName] || 0,\n                        };\n                    })\n                    .reduce((acc, val) => ({ ...acc, ...val }), {}),\n            } as { mutation: string } & Proportions;\n        })\n        .filter((row) =>\n            Object.values(row).some(\n                (value) =>\n                    typeof value === 'number' && value >= proportionInterval.min && value <= proportionInterval.max,\n            ),\n        );\n}\n","import { Grid } from 'gridjs';\nimport { type OneDArray, type TColumn, type TData } from 'gridjs/dist/src/types';\nimport { type PaginationConfig } from 'gridjs/dist/src/view/plugin/pagination';\nimport { type ComponentChild } from 'preact';\nimport { useEffect, useRef } from 'preact/hooks';\nimport 'gridjs/dist/theme/mermaid.css';\n\nexport const tableStyle = {\n    table: {\n        fontSize: '12px',\n    },\n    th: {\n        padding: '4px',\n        textAlign: 'center',\n    },\n    td: {\n        textAlign: 'center',\n        padding: '8px',\n    },\n    footer: {\n        fontSize: '12px',\n    },\n};\n\ninterface TableProps {\n    data: TData;\n    columns: OneDArray<TColumn | string | ComponentChild>;\n    pagination: PaginationConfig | boolean;\n}\n\nexport const Table = ({ data, columns, pagination }: TableProps) => {\n    const wrapper = useRef(null);\n\n    useEffect(() => {\n        if (wrapper.current === null) {\n            return;\n        }\n        const grid = new Grid({\n            columns,\n            data,\n            style: tableStyle,\n            pagination,\n        }).render(wrapper.current);\n\n        return () => {\n            grid.destroy();\n        };\n    });\n\n    return <div ref={wrapper} />;\n};\n","export const substitutionAndDeletionRegex = /(?:([A-Za-z0-9]+):)?([A-Za-z])(\\d+)([A-Za-z]|-|\\*)/;\n\nexport const sortSubstitutionsAndDeletions = (a: string, b: string) => {\n    const aMatch = a.match(substitutionAndDeletionRegex);\n    const bMatch = b.match(substitutionAndDeletionRegex);\n\n    if (aMatch && bMatch) {\n        if (aMatch[1] !== bMatch[1]) {\n            return aMatch[1].localeCompare(bMatch[1]);\n        }\n        if (aMatch[3] !== bMatch[3]) {\n            return parseInt(aMatch[3], 10) - parseInt(bMatch[3], 10);\n        }\n        return aMatch[4].localeCompare(bMatch[4]);\n    }\n    throw new Error(`Invalid substitution or deletion: ${a} or ${b}`);\n};\n","export const formatProportion = (proportion: number) => {\n    return `${(proportion * 100).toFixed(2)}%`;\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getMutationComparisonTableData } from './getMutationComparisonTableData';\nimport { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { Table } from '../components/table';\nimport { sortSubstitutionsAndDeletions } from '../shared/sort/sortSubstitutionsAndDeletions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\nexport interface MutationsTableProps {\n    data: Dataset<MutationData>;\n    proportionInterval: ProportionInterval;\n}\n\nexport const MutationComparisonTable: FunctionComponent<MutationsTableProps> = ({ data, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Mutation',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortSubstitutionsAndDeletions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Prevalence',\n                columns: data.content.map((mutationData) => {\n                    return {\n                        name: mutationData.displayName,\n                        sort: true,\n                        formatter: (cell: number) => formatProportion(cell),\n                    };\n                }),\n            },\n        ];\n    };\n\n    const tableData = getMutationComparisonTableData(data, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { Chart, type ChartConfiguration } from 'chart.js';\nimport { useEffect, useRef } from 'preact/hooks';\n\nexport interface GsChartProps {\n    configuration: ChartConfiguration;\n}\n\nconst GsChart = ({ configuration }: GsChartProps) => {\n    const canvasRef = useRef<HTMLCanvasElement>(null);\n    const chartRef = useRef<Chart | null>(null);\n\n    useEffect(() => {\n        if (canvasRef.current === null) {\n            return;\n        }\n\n        const ctx = canvasRef.current.getContext('2d');\n        if (ctx === null) {\n            return;\n        }\n\n        chartRef.current = new Chart(ctx, configuration);\n\n        return () => {\n            chartRef.current?.destroy();\n        };\n    }, [canvasRef, configuration]);\n\n    return <canvas ref={canvasRef} />;\n};\n\nexport default GsChart;\n","import { type ActiveElement, Chart, type ChartConfiguration, type ChartEvent, registerables } from 'chart.js';\nimport { ArcSlice, extractSets, VennDiagramController } from 'chartjs-chart-venn';\nimport { type FunctionComponent } from 'preact';\nimport { useEffect, useMemo, useRef, useState } from 'preact/hooks';\n\nimport { type MutationData } from './queryMutationData';\nimport { type Dataset } from '../../operator/Dataset';\nimport GsChart from '../components/chart';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\nChart.register(...registerables, VennDiagramController, ArcSlice);\n\nexport interface MutationComparisonVennProps {\n    data: Dataset<MutationData>;\n    proportionInterval: ProportionInterval;\n}\n\nexport const MutationComparisonVenn: FunctionComponent<MutationComparisonVennProps> = ({\n    data,\n    proportionInterval,\n}) => {\n    const divRef = useRef<HTMLDivElement>(null);\n    const noElementSelectedMessage = 'You have no elements selected. Click in the venn diagram to select.';\n    const [selectedDatasetIndex, setSelectedDatasetIndex] = useState<null | number>(null);\n\n    const sets = useMemo(\n        () =>\n            extractSets(\n                data.content\n                    .map((mutationData) => ({\n                        displayName: mutationData.displayName,\n                        data: mutationData.data.filter(\n                            (mutationEntry) =>\n                                mutationEntry.proportion >= proportionInterval.min &&\n                                mutationEntry.proportion <= proportionInterval.max,\n                        ),\n                    }))\n                    .map((mutationData) => {\n                        return {\n                            label: mutationData.displayName,\n                            values: mutationData.data.map((mutationEntry) => mutationEntry.mutation.toString()),\n                        };\n                    }),\n            ),\n        [data, proportionInterval],\n    );\n\n    useEffect(() => {\n        if (divRef.current === null) {\n            return;\n        }\n        if (selectedDatasetIndex === null) {\n            divRef.current.innerText = noElementSelectedMessage;\n            return;\n        }\n\n        const values = sets.datasets[0].data[selectedDatasetIndex].values;\n        const label = sets.datasets[0].data[selectedDatasetIndex].label;\n        divRef.current!.innerText = `${label}: ${values.join(', ')}` || '';\n    }, [divRef, selectedDatasetIndex, sets]);\n\n    const config: ChartConfiguration = useMemo(\n        () => ({\n            type: 'venn',\n            data: sets,\n            options: {\n                scales: {\n                    x: {\n                        ticks: {\n                            color: 'black',\n                            font: {\n                                size: 20,\n                            },\n                        },\n                    },\n                    y: {\n                        ticks: {\n                            color: 'blue',\n                            font: {\n                                size: 20,\n                            },\n                        },\n                    },\n                },\n                events: ['click'],\n                onClick(_: ChartEvent, elements: ActiveElement[]) {\n                    if (elements.length === 0) {\n                        setSelectedDatasetIndex(null);\n                    }\n                },\n                backgroundColor: '#f5f5f5',\n                animation: false,\n                layout: {\n                    padding: 30,\n                },\n                plugins: {\n                    legend: {\n                        display: false,\n                    },\n                    tooltip: {\n                        filter: ({ dataIndex }) => {\n                            setSelectedDatasetIndex(dataIndex);\n                            return false;\n                        },\n                    },\n                },\n            },\n        }),\n        [sets],\n    );\n\n    if (data.content.length > 5) {\n        return <div>Too many variants to display. Maximum are five. </div>;\n    }\n\n    return (\n        <>\n            <GsChart configuration={config} />\n            <div class='flex flex-wrap break-words m-2' ref={divRef} />\n        </>\n    );\n};\n","import { type SequenceType } from '../types';\n\nexport interface Mutation {\n    readonly segment: string | undefined;\n    readonly position: number;\n    readonly code: string;\n\n    equals(other: Mutation): boolean;\n\n    toString(): string;\n}\n\nexport const substitutionRegex =\n    /^((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<valueAtReference>[A-Za-z])?(?<position>\\d+)(?<substitutionValue>[A-Za-z.])?$/;\n\nexport class Substitution implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly valueAtReference: string | undefined,\n        readonly substitutionValue: string | undefined,\n        readonly position: number,\n    ) {\n        const segmentString = this.segment ? `${this.segment}:` : '';\n        const valueAtReferenceString = this.valueAtReference ? `${this.valueAtReference}` : '';\n        const substitutionValueString = this.substitutionValue ? `${this.substitutionValue}` : '';\n        this.code = `${segmentString}${valueAtReferenceString}${this.position}${substitutionValueString}`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Substitution)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.valueAtReference === other.valueAtReference &&\n            this.substitutionValue === other.substitutionValue &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Substitution | null {\n        const match = mutationStr.match(substitutionRegex);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n        return new Substitution(\n            match.groups.segment,\n            match.groups.valueAtReference,\n            match.groups.substitutionValue,\n            parseInt(match.groups.position, 10),\n        );\n    }\n}\n\nexport const deletionRegex = /^((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<valueAtReference>[A-Za-z])?(?<position>\\d+)(-)$/;\n\nexport class Deletion implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly valueAtReference: string | undefined,\n        readonly position: number,\n    ) {\n        const segmentString = this.segment ? `${this.segment}:` : '';\n        const valueAtReferenceString = this.valueAtReference ? `${this.valueAtReference}` : '';\n        this.code = `${segmentString}${valueAtReferenceString}${this.position}-`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Deletion)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.valueAtReference === other.valueAtReference &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Deletion | null {\n        const match = mutationStr.match(deletionRegex);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n\n        return new Deletion(match.groups.segment, match.groups.valueAtReference, parseInt(match.groups.position, 10));\n    }\n}\n\nexport const insertionRegexp =\n    /^ins_((?<segment>[A-Za-z0-9_-]+)(?=:):)?(?<position>\\d+):(?<insertedSymbols>(([A-Za-z?]|(\\.\\*))+))$/i;\n\nexport class Insertion implements Mutation {\n    readonly code;\n\n    constructor(\n        readonly segment: string | undefined,\n        readonly position: number,\n        readonly insertedSymbols: string,\n    ) {\n        this.code = `ins_${this.segment ? `${this.segment}:` : ''}${this.position}:${this.insertedSymbols}`;\n    }\n\n    equals(other: Mutation): boolean {\n        if (!(other instanceof Insertion)) {\n            return false;\n        }\n        return (\n            this.segment === other.segment &&\n            this.insertedSymbols === other.insertedSymbols &&\n            this.position === other.position\n        );\n    }\n\n    toString() {\n        return this.code;\n    }\n\n    static parse(mutationStr: string): Insertion | null {\n        const match = mutationStr.match(insertionRegexp);\n        if (match === null || match.groups === undefined) {\n            return null;\n        }\n\n        return new Insertion(match.groups.segment, parseInt(match.groups.position, 10), match.groups.insertedSymbols);\n    }\n}\n\nexport const bases: { [P in SequenceType]: string[] } = {\n    nucleotide: ['A', 'C', 'G', 'T', '-'],\n    'amino acid': [\n        'I',\n        'L',\n        'V',\n        'F',\n        'M',\n        'C',\n        'A',\n        'G',\n        'P',\n        'T',\n        'S',\n        'Y',\n        'W',\n        'Q',\n        'N',\n        'H',\n        'E',\n        'D',\n        'K',\n        'R',\n        '-',\n    ],\n};\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchSubstitutionsOrDeletions } from '../lapisApi/lapisApi';\nimport { type LapisFilter, type SequenceType, type SubstitutionOrDeletionEntry } from '../types';\nimport { Deletion, Substitution } from '../utils/mutations';\n\nexport class FetchSubstitutionsOrDeletionsOperator implements Operator<SubstitutionOrDeletionEntry> {\n    constructor(\n        private filter: LapisFilter,\n        private sequenceType: SequenceType,\n        private minProportion?: number,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<SubstitutionOrDeletionEntry>> {\n        const mutations = await this.fetchMutations(lapis, signal);\n\n        const content: SubstitutionOrDeletionEntry[] = mutations.map(\n            ({ count, proportion, mutationFrom, mutationTo, position, sequenceName }) => {\n                if (mutationTo === '-') {\n                    return {\n                        type: 'deletion',\n                        mutation: new Deletion(sequenceName ?? undefined, mutationFrom, position),\n                        count,\n                        proportion,\n                    };\n                }\n                return {\n                    type: 'substitution',\n                    mutation: new Substitution(sequenceName ?? undefined, mutationFrom, mutationTo, position),\n                    count,\n                    proportion,\n                };\n            },\n        );\n\n        return { content };\n    }\n\n    private async fetchMutations(lapis: string, signal?: AbortSignal) {\n        const filter = {\n            ...this.filter,\n            minProportion: this.minProportion,\n        };\n\n        return fetchSubstitutionsOrDeletions(lapis, filter, this.sequenceType, signal).then(\n            (response) => response.data,\n        );\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class SortOperator<S> implements Operator<S> {\n    constructor(\n        private child: Operator<S>,\n        private compareFn: (a: S, b: S) => number,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<S>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        return {\n            content: childEvaluated.content.sort(this.compareFn),\n        };\n    }\n}\n","import { FetchSubstitutionsOrDeletionsOperator } from '../operator/FetchSubstitutionsOrDeletionsOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type SequenceType } from '../types';\n\nexport function querySubstitutionsOrDeletions(\n    variant: LapisFilter,\n    sequenceType: SequenceType,\n    lapis: string,\n    signal?: AbortSignal,\n) {\n    const fetchData = new FetchSubstitutionsOrDeletionsOperator(variant, sequenceType, 0);\n    const sortData = new SortOperator(fetchData, (a, b) => {\n        if (a.mutation.segment !== b.mutation.segment) {\n            return (a.mutation.segment ?? '').localeCompare(b.mutation.segment ?? '');\n        }\n        return a.mutation.position - b.mutation.position;\n    });\n    return sortData.evaluate(lapis, signal);\n}\n","import { type MutationComparisonVariant } from './mutation-comparison';\nimport { querySubstitutionsOrDeletions } from '../../query/querySubstitutionsOrDeletions';\nimport { type SubstitutionOrDeletionEntry } from '../../types';\nimport { type DisplayedSegment } from '../components/SegmentSelector';\nimport { type DisplayedMutationType } from '../components/mutation-type-selector';\n\nexport type MutationData = {\n    displayName: string;\n    data: SubstitutionOrDeletionEntry[];\n};\n\nexport async function queryMutationData(\n    variants: MutationComparisonVariant[],\n    sequenceType: 'nucleotide' | 'amino acid',\n    lapis: string,\n) {\n    const mutationData = await Promise.all(\n        variants.map(async (variant) => {\n            return {\n                displayName: variant.displayName,\n                data: (await querySubstitutionsOrDeletions(variant.lapisFilter, sequenceType, lapis)).content,\n            };\n        }),\n    );\n    return { mutationData };\n}\n\nexport function filterMutationData(\n    data: MutationData[],\n    displayedSegments: DisplayedSegment[],\n    displayedMutationTypes: DisplayedMutationType[],\n) {\n    const byDisplayedSegments = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        if (mutationEntry.mutation.segment === undefined) {\n            return true;\n        }\n        return displayedSegments.some(\n            (displayedSegment) =>\n                displayedSegment.segment === mutationEntry.mutation.segment && displayedSegment.checked,\n        );\n    };\n    const byDisplayedMutationTypes = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return displayedMutationTypes.some(\n            (displayedMutationType) =>\n                displayedMutationType.checked && displayedMutationType.type === mutationEntry.type,\n        );\n    };\n\n    return data.map((mutationEntry) => ({\n        displayName: mutationEntry.displayName,\n        data: mutationEntry.data.filter(byDisplayedSegments).filter(byDisplayedMutationTypes),\n    }));\n}\n","import { createContext } from 'preact';\n\nexport const LapisUrlContext = createContext('');\n","export type CheckboxItem = {\n    label: string;\n    checked: boolean;\n};\n\nexport interface CheckboxSelectorProps<Item extends CheckboxItem = CheckboxItem> {\n    className?: string;\n    items: Item[];\n    label: string;\n    setItems: (items: Item[]) => void;\n}\n\nexport const CheckboxSelector = <Item extends CheckboxItem>({\n    className,\n    items,\n    label,\n    setItems,\n}: CheckboxSelectorProps<Item>) => {\n    return (\n        <div class={`dropdown ${className}`}>\n            <div tabIndex={0} role='button' class='btn btn-xs text-nowrap'>\n                {label}\n            </div>\n            <ul tabIndex={0} class='p-2 shadow menu dropdown-content z-[1] bg-base-100 rounded-box'>\n                {items.map((item, index) => (\n                    <li class='flex flex-row items-center' key={item.label}>\n                        <label>\n                            <input\n                                type='checkbox'\n                                id={`item-${index}`}\n                                checked={item.checked}\n                                onChange={() => {\n                                    const newItems = items.map((item, i) =>\n                                        i === index ? { ...item, checked: !item.checked } : item,\n                                    );\n                                    setItems(newItems);\n                                }}\n                            />\n                            {item.label}\n                        </label>\n                    </li>\n                ))}\n            </ul>\n        </div>\n    );\n};\n","import { createContext } from 'preact';\n\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\n\nexport const ReferenceGenomeContext = createContext<ReferenceGenome>({ nucleotideSequences: [], genes: [] });\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport { type CheckboxItem, CheckboxSelector } from './checkbox-selector';\nimport { getSegmentNames } from '../../lapisApi/ReferenceGenome';\nimport { type SequenceType } from '../../types';\nimport { ReferenceGenomeContext } from '../ReferenceGenomeContext';\n\nexport type DisplayedSegment = CheckboxItem & {\n    segment: string;\n};\n\nexport type SegmentSelectorProps = {\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (items: DisplayedSegment[]) => void;\n    prefix?: string;\n};\n\nconst getSegmentSelectorLabel = (displayedSegments: DisplayedSegment[], prefix: string) => {\n    const allSelectedSelected = displayedSegments\n        .filter((segment) => segment.checked)\n        .map((segment) => segment.segment);\n\n    if (allSelectedSelected.length === 0) {\n        return `${prefix}none`;\n    }\n    if (displayedSegments.length === allSelectedSelected.length) {\n        return `${prefix}all`;\n    }\n    return prefix + allSelectedSelected.join(', ');\n};\n\nexport const SegmentSelector: FunctionComponent<SegmentSelectorProps> = ({\n    displayedSegments,\n    setDisplayedSegments,\n    prefix,\n}) => {\n    if (displayedSegments.length <= 1) {\n        return null;\n    }\n\n    return (\n        <CheckboxSelector\n            className='mx-1'\n            items={displayedSegments}\n            label={getSegmentSelectorLabel(displayedSegments, prefix || 'Segments: ')}\n            setItems={(items) => setDisplayedSegments(items)}\n        />\n    );\n};\n\nexport function useDisplayedSegments(sequenceType: SequenceType) {\n    const referenceGenome = useContext(ReferenceGenomeContext);\n\n    const displayedSegments = getSegmentNames(referenceGenome, sequenceType).map((segment) => ({\n        segment,\n        label: segment,\n        checked: true,\n    }));\n\n    return useState<DisplayedSegment[]>(displayedSegments);\n}\n","import { type FunctionComponent } from 'preact';\n\nexport interface CsvDownloadButtonProps {\n    label?: string;\n    filename?: string;\n    getData: () => Record<string, string | number | boolean | null>[];\n    className?: string;\n}\n\nexport const CsvDownloadButton: FunctionComponent<CsvDownloadButtonProps> = ({\n    label = 'Download',\n    filename = 'data.csv',\n    getData,\n    className,\n}) => {\n    const download = () => {\n        const content = getDownloadContent();\n        const blob = new Blob([content], { type: 'text/csv' });\n        const url = URL.createObjectURL(blob);\n        const a = document.createElement('a');\n        a.href = url;\n        a.download = filename;\n        a.click();\n        URL.revokeObjectURL(url);\n    };\n\n    const getDownloadContent = () => {\n        const data = getData();\n        const keys = getDataKeys(data);\n        const header = `${keys.join(',')}\\n`;\n        const rows = data.map((row) => keys.map((key) => row[key]).join(',')).join('\\n');\n        return header + rows;\n    };\n\n    const getDataKeys = (data: Record<string, string | number | boolean | null>[]) => {\n        const keysSet = data\n            .map((row) => Object.keys(row))\n            .reduce((accumulatedKeys, keys) => {\n                keys.forEach((key) => accumulatedKeys.add(key));\n                return accumulatedKeys;\n            }, new Set<string>());\n\n        return [...keysSet];\n    };\n\n    return (\n        <button className={className} onClick={download}>\n            {label}\n        </button>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nexport const ErrorDisplay: FunctionComponent<{ error: Error }> = ({ error }) => {\n    return <div>Error: {error.message}</div>;\n};\n","import { type FunctionComponent } from 'preact';\n\nexport interface HeadlineProps {\n    heading: string;\n}\n\nconst Headline: FunctionComponent<HeadlineProps> = ({ heading, children }) => {\n    return (\n        <>\n            <h1>{heading}</h1>\n            {children}\n        </>\n    );\n};\n\nexport default Headline;\n","import { type FunctionComponent } from 'preact';\n\nexport interface InfoProps {\n    content: string;\n    className?: string;\n}\n\nconst Info: FunctionComponent<InfoProps> = ({ content, className }) => {\n    return (\n        <div class={`${className} tooltip`} data-tip={content}>\n            <button class='btn btn-xs'>?</button>\n        </div>\n    );\n};\n\nexport default Info;\n","import { type FunctionComponent } from 'preact';\n\nexport const LoadingDisplay: FunctionComponent = () => {\n    return <div>Loading...</div>;\n};\n","import { type FunctionComponent } from 'preact/compat';\n\nimport { type CheckboxItem, CheckboxSelector } from './checkbox-selector';\nimport type { SubstitutionOrDeletion } from '../../types';\n\nexport type DisplayedMutationType = CheckboxItem & {\n    type: SubstitutionOrDeletion;\n};\n\nexport type MutationTypeSelectorProps = {\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (mutationTypes: DisplayedMutationType[]) => void;\n};\n\nexport const MutationTypeSelector: FunctionComponent<MutationTypeSelectorProps> = ({\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n}) => {\n    const checkedLabels = displayedMutationTypes.filter((type) => type.checked).map((type) => type.label);\n    const mutationTypesSelectorLabel = `Types: ${checkedLabels.length > 0 ? checkedLabels.join(', ') : 'None'}`;\n\n    return (\n        <CheckboxSelector\n            className='mx-1'\n            items={displayedMutationTypes}\n            label={mutationTypesSelectorLabel}\n            setItems={(items) => setDisplayedMutationTypes(items)}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nexport const NoDataDisplay: FunctionComponent = () => {\n    return <div>No data available.</div>;\n};\n","import { type FunctionComponent } from 'preact';\nimport { useState } from 'preact/hooks';\nimport { type ChangeEvent } from 'react';\nimport './min-max-percent-slider.css';\n\nexport interface MinMaxPercentSliderProps {\n    min: number;\n    max: number;\n    setMin: (min: number) => void;\n    setMax: (max: number) => void;\n    rangeMin?: number;\n    rangeMax?: number;\n    step?: number;\n}\n\nexport const MinMaxRangeSlider: FunctionComponent<MinMaxPercentSliderProps> = ({\n    min,\n    max,\n    setMin,\n    setMax,\n    rangeMin = 0,\n    rangeMax = 100,\n    step = 0.1,\n}) => {\n    const sliderColor = '#C6C6C6';\n    const rangeColor = '#387bbe';\n\n    const [zIndexTo, setZIndexTo] = useState(0);\n\n    const onMinChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const minValue = Number(input.value);\n\n        if (minValue > max) {\n            setMax(minValue);\n            setMin(minValue);\n        } else {\n            setMin(minValue);\n        }\n    };\n\n    const onMaxChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const maxValue = Number(input.value);\n\n        if (maxValue <= 0) {\n            setZIndexTo(2);\n        } else {\n            setZIndexTo(0);\n        }\n\n        if (maxValue < min) {\n            setMin(maxValue);\n            setMax(maxValue);\n        } else {\n            setMax(maxValue);\n        }\n    };\n\n    const background = `\n        linear-gradient(\n            to right,\n            ${sliderColor} 0%,\n            ${sliderColor} ${min}%,\n            ${rangeColor} ${min}%,\n            ${rangeColor} ${max}%,\n            ${sliderColor} ${max}%,\n            ${sliderColor} 100%)\n    `;\n\n    return (\n        <div class='my-4 relative'>\n            <input\n                id='fromSlider'\n                type='range'\n                value={min}\n                onInput={onMinChange}\n                min={rangeMin}\n                max={rangeMax}\n                step={step}\n                style={{ background, zIndex: 1, height: 0 }}\n            />\n            <input\n                id='toSlider'\n                type='range'\n                value={max}\n                min={rangeMin}\n                max={rangeMax}\n                step={step}\n                onInput={onMaxChange}\n                style={{ background, zIndex: zIndexTo }}\n            />\n        </div>\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useEffect, useState } from 'preact/hooks';\nimport { type ChangeEvent } from 'react';\n\nexport type PercentInputProps = {\n    percentage: number;\n    setPercentage: (percentage: number) => void;\n};\n\nconst percentageInRange = (percentage: number) => {\n    return percentage <= 100 && percentage >= 0;\n};\n\nexport const PercentInput: FunctionComponent<PercentInputProps> = ({ percentage, setPercentage }) => {\n    const [internalPercentage, setInternalPercentage] = useState(percentage);\n\n    useEffect(() => {\n        setInternalPercentage(percentage);\n    }, [percentage]);\n\n    const handleInputChange = (event: ChangeEvent<HTMLInputElement>) => {\n        const input = event.target as HTMLInputElement;\n        const value = Number(input.value);\n\n        const inRange = percentageInRange(value);\n\n        if (inRange) {\n            setPercentage(value);\n        }\n        setInternalPercentage(value);\n    };\n\n    const isError = !percentageInRange(internalPercentage);\n    return (\n        <label className={`input input-bordered flex items-center gap-2 w-32 ${isError ? 'input-error' : ''}`}>\n            <input\n                type='number'\n                step={0.1}\n                min={0}\n                max={100}\n                value={internalPercentage}\n                onInput={handleInputChange}\n                lang='en'\n                className={`grow w-16`}\n            />\n            %\n        </label>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { MinMaxRangeSlider } from './min-max-range-slider';\nimport { PercentInput } from './percent-intput';\n\nexport type ProportionInterval = { min: number; max: number };\n\nexport interface ProportionSelectorProps {\n    proportionInterval: ProportionInterval;\n    setMinProportion: (minProportion: number) => void;\n    setMaxProportion: (maxProportion: number) => void;\n}\n\nexport const ProportionSelector: FunctionComponent<ProportionSelectorProps> = ({\n    proportionInterval,\n    setMinProportion,\n    setMaxProportion,\n}) => {\n    const { min: minProportion, max: maxProportion } = proportionInterval;\n    return (\n        <div class='flex flex-col w-64 mb-2'>\n            <div class='flex items-center '>\n                <PercentInput\n                    percentage={minProportion * 100}\n                    setPercentage={(percentage) => setMinProportion(percentage / 100)}\n                />\n                <div class='m-2'>-</div>\n                <PercentInput\n                    percentage={maxProportion * 100}\n                    setPercentage={(percentage) => setMaxProportion(percentage / 100)}\n                />\n            </div>\n            <div class='my-1'>\n                <MinMaxRangeSlider\n                    min={minProportion * 100}\n                    max={maxProportion * 100}\n                    setMin={(percentage) => setMinProportion(percentage / 100)}\n                    setMax={(percentage) => setMaxProportion(percentage / 100)}\n                />\n            </div>\n        </div>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { ProportionSelector, type ProportionSelectorProps } from './proportion-selector';\n\nexport interface ProportionSelectorDropdownProps extends ProportionSelectorProps {\n    openDirection?: 'left' | 'right';\n}\n\nexport const ProportionSelectorDropdown: FunctionComponent<ProportionSelectorDropdownProps> = ({\n    proportionInterval,\n    setMinProportion,\n    setMaxProportion,\n    openDirection = 'right',\n}) => {\n    const label = `${(proportionInterval.min * 100).toFixed(1)}% - ${(proportionInterval.max * 100).toFixed(1)}%`;\n\n    return (\n        <div class={`dropdown ${openDirection === 'left' ? 'dropdown-end' : ''}`}>\n            <div tabIndex={0} role='button' class='btn btn-xs whitespace-nowrap'>\n                Proportion {label}\n            </div>\n            <ul tabIndex={0} class='p-2 shadow menu dropdown-content z-[1] bg-base-100 rounded-box w-72'>\n                <div class='mb-2 ml-2'>\n                    <ProportionSelector\n                        proportionInterval={proportionInterval}\n                        setMinProportion={setMinProportion}\n                        setMaxProportion={setMaxProportion}\n                    />\n                </div>\n            </ul>\n        </div>\n    );\n};\n","import { Fragment, type FunctionComponent } from 'preact';\nimport { useState } from 'preact/hooks';\nimport { type JSXInternal } from 'preact/src/jsx';\n\ntype Tab = {\n    title: string;\n    content: JSXInternal.Element;\n};\n\ninterface ComponentTabsProps {\n    tabs: Tab[];\n    toolbar?: JSXInternal.Element | ((activeTab: string) => JSXInternal.Element);\n}\n\nconst Tabs: FunctionComponent<ComponentTabsProps> = ({ tabs, toolbar }) => {\n    const [activeTab, setActiveTab] = useState(tabs[0].title);\n\n    const tabNames = tabs.map((tab) => tab.title).join(', ');\n\n    const tabElements = tabs.map((tab) => {\n        return (\n            <Fragment key={tab.title}>\n                <input\n                    type='radio'\n                    name={tabNames}\n                    role='tab'\n                    className='tab'\n                    aria-label={tab.title}\n                    checked={activeTab === tab.title}\n                    onChange={() => setActiveTab(tab.title)}\n                />\n                <div role='tabpanel' className='tab-content bg-base-100 border-base-300 rounded-box p-1'>\n                    {tab.content}\n                </div>\n            </Fragment>\n        );\n    });\n\n    const toolbarElement = typeof toolbar === 'function' ? toolbar(activeTab) : toolbar;\n\n    return (\n        <div role='tablist' className='tabs tabs-lifted'>\n            {tabElements}\n            {toolbar && <div className='m-1 col-[9999]'>{toolbarElement}</div>}\n        </div>\n    );\n};\n\nexport default Tabs;\n","import { useEffect, useState } from 'preact/hooks';\n\nexport function useQuery<Data>(fetchDataCallback: () => Promise<Data>, dependencies: unknown[] = []) {\n    const [data, setData] = useState<Data | null>(null);\n    const [error, setError] = useState<Error | null>(null);\n    const [isLoading, setIsLoading] = useState(true);\n\n    useEffect(() => {\n        const fetchData = async () => {\n            setIsLoading(true);\n            try {\n                const result = await fetchDataCallback();\n                setData(result);\n                setError(null);\n            } catch (error) {\n                setError(error as Error);\n            } finally {\n                setIsLoading(false);\n            }\n        };\n\n        fetchData();\n        // eslint-disable-next-line react-hooks/exhaustive-deps\n    }, [JSON.stringify(dependencies)]);\n\n    return { data, error, isLoading };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type Dispatch, type StateUpdater, useContext, useMemo, useState } from 'preact/hooks';\n\nimport { getMutationComparisonTableData } from './getMutationComparisonTableData';\nimport { MutationComparisonTable } from './mutation-comparison-table';\nimport { MutationComparisonVenn } from './mutation-comparison-venn';\nimport { filterMutationData, type MutationData, queryMutationData } from './queryMutationData';\nimport { type LapisFilter, type SequenceType } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { type DisplayedSegment, SegmentSelector, useDisplayedSegments } from '../components/SegmentSelector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { type DisplayedMutationType, MutationTypeSelector } from '../components/mutation-type-selector';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { ProportionSelectorDropdown } from '../components/proportion-selector-dropdown';\nimport Tabs from '../components/tabs';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'table' | 'venn';\n\nexport interface MutationComparisonVariant {\n    lapisFilter: LapisFilter;\n    displayName: string;\n}\n\nexport interface MutationComparisonProps {\n    variants: MutationComparisonVariant[];\n    sequenceType: SequenceType;\n    views: View[];\n}\n\nexport const MutationComparison: FunctionComponent<MutationComparisonProps> = ({ variants, sequenceType, views }) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const { data, error, isLoading } = useQuery(async () => {\n        return queryMutationData(variants, sequenceType, lapis);\n    }, [variants, sequenceType, lapis]);\n\n    const headline = 'Mutation comparison';\n\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <MutationComparisonTabs data={data.mutationData} sequenceType={sequenceType} views={views} />\n        </Headline>\n    );\n};\n\ntype MutationComparisonTabsProps = {\n    data: MutationData[];\n    views: View[];\n    sequenceType: SequenceType;\n};\n\nconst MutationComparisonTabs: FunctionComponent<MutationComparisonTabsProps> = ({ data, views, sequenceType }) => {\n    const [proportionInterval, setProportionInterval] = useState({ min: 0.5, max: 1 });\n    const [displayedMutationTypes, setDisplayedMutationTypes] = useState<DisplayedMutationType[]>([\n        { label: 'Substitutions', checked: true, type: 'substitution' },\n        { label: 'Deletions', checked: true, type: 'deletion' },\n    ]);\n    const [displayedSegments, setDisplayedSegments] = useDisplayedSegments(sequenceType);\n\n    const filteredData = useMemo(\n        () => filterMutationData(data, displayedSegments, displayedMutationTypes),\n        [data, displayedSegments, displayedMutationTypes],\n    );\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'table':\n                return {\n                    title: 'Table',\n                    content: (\n                        <MutationComparisonTable\n                            data={{ content: filteredData }}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n            case 'venn':\n                return {\n                    title: 'Venn',\n                    content: (\n                        <MutationComparisonVenn\n                            data={{ content: filteredData }}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    return (\n        <Tabs\n            tabs={tabs}\n            toolbar={\n                <Toolbar\n                    displayedSegments={displayedSegments}\n                    setDisplayedSegments={setDisplayedSegments}\n                    displayedMutationTypes={displayedMutationTypes}\n                    setDisplayedMutationTypes={setDisplayedMutationTypes}\n                    filteredData={filteredData}\n                    proportionInterval={proportionInterval}\n                    setProportionInterval={setProportionInterval}\n                />\n            }\n        />\n    );\n};\n\ntype ToolbarProps = {\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (segments: DisplayedSegment[]) => void;\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (types: DisplayedMutationType[]) => void;\n    filteredData: MutationData[];\n    proportionInterval: ProportionInterval;\n    setProportionInterval: Dispatch<StateUpdater<ProportionInterval>>;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    displayedSegments,\n    setDisplayedSegments,\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n    filteredData,\n    proportionInterval,\n    setProportionInterval,\n}) => {\n    return (\n        <div class='flex flex-row'>\n            <ProportionSelectorDropdown\n                proportionInterval={proportionInterval}\n                setMinProportion={(min) => setProportionInterval((prev) => ({ ...prev, min }))}\n                setMaxProportion={(max) => setProportionInterval((prev) => ({ ...prev, max }))}\n            />\n            <SegmentSelector displayedSegments={displayedSegments} setDisplayedSegments={setDisplayedSegments} />\n            <MutationTypeSelector\n                displayedMutationTypes={displayedMutationTypes}\n                setDisplayedMutationTypes={setDisplayedMutationTypes}\n            />\n            <CsvDownloadButton\n                className='mx-1 btn btn-xs'\n                getData={() => getMutationComparisonTableData({ content: filteredData }, proportionInterval)}\n                filename='mutation_comparison.csv'\n            />\n            <Info className='mx-1' content='Info for mutation comparison' />\n        </div>\n    );\n};\n","import { consume } from '@lit/context';\nimport { type PropertyValues, ReactiveElement } from '@lit/reactive-element';\nimport { unsafeCSS } from 'lit';\nimport { render } from 'preact';\nimport { type JSXInternal } from 'preact/src/jsx';\n\nimport { lapisContext } from './lapis-context';\nimport { referenceGenomeContext } from './reference-genome-context';\nimport { type ReferenceGenome } from '../lapisApi/ReferenceGenome';\nimport { LapisUrlContext } from '../preact/LapisUrlContext';\nimport { ReferenceGenomeContext } from '../preact/ReferenceGenomeContext';\nimport minMaxPercentSliderCss from '../preact/components/min-max-percent-slider.css?inline';\nimport tailwindStyle from '../styles/tailwind.css?inline';\n\nimport '../styles/tailwind.css';\nimport '../preact/components/min-max-percent-slider.css';\n\nconst tailwindElementCss = unsafeCSS(tailwindStyle);\nconst minMaxPercentSliderElementCss = unsafeCSS(minMaxPercentSliderCss);\n\nexport abstract class PreactLitAdapter extends ReactiveElement {\n    static override styles = [tailwindElementCss, minMaxPercentSliderElementCss];\n\n    /**\n     * @internal\n     * The URL of the Lapis instance.\n     *\n     * This component must be a child of a `gs-app` component.\n     * This value will automatically be injected by the parent `gs-app` component.\n     */\n    @consume({ context: lapisContext })\n    lapis: string = '';\n\n    /**\n     * @internal\n     * The reference genomes of the underlying organism.\n     * These will be fetched from the Lapis instance.\n     *\n     * This component must be a child of a `gs-app` component.\n     * This value will automatically be injected by the parent `gs-app` component.\n     */\n    @consume({ context: referenceGenomeContext, subscribe: true })\n    referenceGenome: ReferenceGenome = {\n        nucleotideSequences: [],\n        genes: [],\n    };\n\n    override update(changedProperties: PropertyValues) {\n        console.log('this.lapis', this.lapis);\n        const vdom = (\n            <LapisUrlContext.Provider value={this.lapis}>\n                <ReferenceGenomeContext.Provider value={this.referenceGenome}>\n                    {this.render()}\n                </ReferenceGenomeContext.Provider>\n            </LapisUrlContext.Provider>\n        );\n        super.update(changedProperties);\n        render(vdom, this.renderRoot);\n    }\n\n    protected abstract render(): JSXInternal.Element;\n}\n","import gridJsStyle from 'gridjs/dist/theme/mermaid.css?inline';\nimport { unsafeCSS } from 'lit';\n\nimport { PreactLitAdapter } from './PreactLitAdapter';\n\nimport 'gridjs/dist/theme/mermaid.css';\n\nconst gridJsElementCss = unsafeCSS(gridJsStyle);\n\nexport abstract class PreactLitAdapterWithGridJsStyles extends PreactLitAdapter {\n    static override styles = [...PreactLitAdapter.styles, gridJsElementCss];\n}\n","import { customElement, property } from 'lit/decorators.js';\n\nimport {\n    MutationComparison,\n    type MutationComparisonVariant,\n    type View,\n} from '../../preact/mutationComparison/mutation-comparison';\nimport { type SequenceType } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-mutation-comparison-component')\nexport class MutationComparisonComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Array })\n    variants: MutationComparisonVariant[] = [];\n\n    @property({ type: String })\n    sequenceType: SequenceType = 'nucleotide';\n\n    @property({ type: Array })\n    views: View[] = ['table'];\n\n    override render() {\n        return <MutationComparison variants={this.variants} sequenceType={this.sequenceType} views={this.views} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-mutation-comparison-component': MutationComparisonComponent;\n    }\n}\n","import { type InsertionEntry } from '../../types';\n\nexport function getInsertionsTableData(data: InsertionEntry[]) {\n    return data.map((mutationEntry) => {\n        return {\n            insertion: mutationEntry.mutation.toString(),\n            count: mutationEntry.count,\n        };\n    });\n}\n","import { type SubstitutionOrDeletionEntry } from '../../types';\nimport { type ProportionInterval } from '../components/proportion-selector';\n\nexport function getMutationsTableData(data: SubstitutionOrDeletionEntry[], proportionInterval: ProportionInterval) {\n    const byProportion = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return mutationEntry.proportion >= proportionInterval.min && mutationEntry.proportion <= proportionInterval.max;\n    };\n\n    return data.filter(byProportion).map((mutationEntry) => {\n        return {\n            mutation: mutationEntry.mutation.toString(),\n            type: mutationEntry.type,\n            count: mutationEntry.count,\n            proportion: mutationEntry.proportion,\n        };\n    });\n}\n","const pattern = /(?:([A-Za-z0-9]+):)?(\\d+)$/;\n\nexport const sortMutationPositions = (a: string, b: string) => {\n    const aMatch = a.match(pattern);\n    const bMatch = b.match(pattern);\n\n    if (aMatch && bMatch) {\n        if (aMatch[1] !== bMatch[1]) {\n            return aMatch[1].localeCompare(bMatch[1]);\n        }\n        return parseInt(aMatch[2], 10) - parseInt(bMatch[2], 10);\n    }\n    throw new Error(`Invalid mutation position: ${a} or ${b}`);\n};\n","import { type BaseCell } from './mutations-grid';\nimport type { SequenceType, SubstitutionOrDeletionEntry } from '../../types';\nimport { bases } from '../../utils/mutations';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { sortMutationPositions } from '../shared/sort/sortMutationPositions';\n\nexport const getMutationsGridData = (\n    data: SubstitutionOrDeletionEntry[],\n    sequenceType: SequenceType,\n    proportionInterval: ProportionInterval,\n) => {\n    return accumulateByPosition(data, sequenceType).filter((row) => byProportion(row, proportionInterval));\n};\n\nconst accumulateByPosition = (data: SubstitutionOrDeletionEntry[], sequenceType: SequenceType) => {\n    const basesOfView = bases[sequenceType];\n    const positionsToProportionAtBase = new Map<string, Map<string | undefined, number>>();\n    const referenceBases = new Map<string, string | undefined>();\n\n    for (const mutationEntry of data) {\n        const position =\n            (mutationEntry.mutation.segment ? `${mutationEntry.mutation.segment}:` : '') +\n            mutationEntry.mutation.position;\n        referenceBases.set(position, mutationEntry.mutation.valueAtReference);\n\n        const initiallyFillPositionsToProportionAtBase = () => {\n            if (!positionsToProportionAtBase.has(position)) {\n                const empty = new Map();\n                basesOfView.forEach((base) => empty.set(base, 0));\n                empty.set(mutationEntry.mutation.valueAtReference, 1);\n                positionsToProportionAtBase.set(position, empty);\n            }\n        };\n        initiallyFillPositionsToProportionAtBase();\n\n        const substitutionValue =\n            mutationEntry.type === 'substitution' ? mutationEntry.mutation.substitutionValue : '-';\n\n        const subtractSubstitutionValue = () => {\n            const proportionAtBase = positionsToProportionAtBase.get(position)!;\n            proportionAtBase.set(substitutionValue, mutationEntry.proportion);\n            proportionAtBase.set(\n                mutationEntry.mutation.valueAtReference,\n                proportionAtBase.get(mutationEntry.mutation.valueAtReference)! - mutationEntry.proportion,\n            );\n        };\n        subtractSubstitutionValue();\n    }\n    const orderedPositionsToProportionAtBase = [...positionsToProportionAtBase.entries()]\n        .map(([position, proportionsAtBase]) => ({ position, proportions: proportionsAtBase }))\n        .sort((a, b) => {\n            return sortMutationPositions(a.position, b.position);\n        });\n\n    return orderedPositionsToProportionAtBase.map((proportionsForBaseAtPosition) => {\n        const proportions = bases[sequenceType].map((base) => {\n            return {\n                [base]: {\n                    proportion: proportionsForBaseAtPosition.proportions.get(base)!,\n                    isReference: base === referenceBases.get(proportionsForBaseAtPosition.position),\n                },\n            };\n        });\n\n        return {\n            position: proportionsForBaseAtPosition.position,\n            ...proportions.reduce((acc, curr) => ({ ...acc, ...curr }), {}),\n        } as MutationsGridDataRow;\n    });\n};\n\nexport type BasesData = {\n    [base: string]: BaseCell;\n};\nexport type MutationsGridDataRow = BasesData & { position: string };\n\nconst byProportion = (row: MutationsGridDataRow, proportionInterval: ProportionInterval) => {\n    const numbersAndIsReference = Object.values(row).filter(\n        (\n            cell,\n        ): cell is {\n            proportion: number;\n            isReference: boolean;\n        } => typeof cell === 'object',\n    );\n\n    return numbersAndIsReference.some((cell) => {\n        return (\n            !cell.isReference && cell.proportion >= proportionInterval.min && cell.proportion <= proportionInterval.max\n        );\n    });\n};\n","import { type Row } from 'gridjs';\nimport { type FunctionComponent } from 'preact';\n\nimport { getMutationsGridData } from './getMutationsGridData';\nimport { type SequenceType, type SubstitutionOrDeletionEntry } from '../../types';\nimport { bases } from '../../utils/mutations';\nimport { type ProportionInterval } from '../components/proportion-selector';\nimport { Table, tableStyle } from '../components/table';\nimport { sortMutationPositions } from '../shared/sort/sortMutationPositions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\ninterface MutationsGridProps {\n    data: SubstitutionOrDeletionEntry[];\n    sequenceType: SequenceType;\n    proportionInterval: ProportionInterval;\n}\n\nexport type BaseCell = {\n    proportion: number;\n    isReference: boolean;\n};\n\nexport const MutationsGrid: FunctionComponent<MutationsGridProps> = ({ data, sequenceType, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Position',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortMutationPositions(a, b);\n                    },\n                },\n            },\n            ...getBasesHeaders(),\n        ];\n    };\n\n    const getBasesHeaders = () => {\n        return bases[sequenceType].map((base) => {\n            return {\n                name: base,\n                sort: {\n                    compare: (a: BaseCell, b: BaseCell) => {\n                        const aProportion = a.proportion;\n                        const bProportion = b.proportion;\n                        if (aProportion < bProportion) {\n                            return -1;\n                        }\n                        if (aProportion > bProportion) {\n                            return 1;\n                        }\n\n                        return 0;\n                    },\n                },\n                formatter: (cell: BaseCell) => formatProportion(cell.proportion),\n                attributes: (cell: BaseCell, row: Row) => {\n                    // grid-js: the cell and row are null for header cells\n                    if (row === null) {\n                        return {};\n                    }\n\n                    return styleCells(cell);\n                },\n            };\n        });\n    };\n\n    const styleCells = (cell: BaseCell) => {\n        if (cell.isReference || cell.proportion < 0.0001) {\n            return {\n                style: {\n                    ...tableStyle.td,\n                    color: 'gray',\n                },\n            };\n        }\n        return {};\n    };\n\n    const tableData = getMutationsGridData(data, sequenceType, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { Insertion } from '../../../utils/mutations';\n\nexport const sortInsertions = (a: string, b: string) => {\n    const insertionA = Insertion.parse(a);\n    const insertionB = Insertion.parse(b);\n\n    if (insertionA && insertionB) {\n        const segmentA = insertionA.segment;\n        const segmentB = insertionB.segment;\n        if (segmentA !== undefined && segmentB !== undefined && segmentA !== segmentB) {\n            return segmentA.localeCompare(segmentB);\n        }\n        const positionA = insertionA.position;\n        const positionB = insertionB.position;\n        if (positionA !== positionB) {\n            return positionA - positionB;\n        }\n        return insertionA.insertedSymbols.localeCompare(insertionB.insertedSymbols);\n    }\n    throw new Error(`Invalid insertion: ${a} or ${b}`);\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getInsertionsTableData } from './getInsertionsTableData';\nimport { type InsertionEntry } from '../../types';\nimport { Table } from '../components/table';\nimport { sortInsertions } from '../shared/sort/sortInsertions';\n\nexport interface InsertionsTableProps {\n    data: InsertionEntry[];\n}\n\nexport const InsertionsTable: FunctionComponent<InsertionsTableProps> = ({ data }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Insertion',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortInsertions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Count',\n                sort: true,\n            },\n        ];\n    };\n\n    const tableData = getInsertionsTableData(data).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { getMutationsTableData } from './getMutationsTableData';\nimport { type SubstitutionOrDeletionEntry } from '../../types';\nimport type { ProportionInterval } from '../components/proportion-selector';\nimport { Table } from '../components/table';\nimport { sortSubstitutionsAndDeletions } from '../shared/sort/sortSubstitutionsAndDeletions';\nimport { formatProportion } from '../shared/table/formatProportion';\n\nexport interface MutationsTableProps {\n    data: SubstitutionOrDeletionEntry[];\n    proportionInterval: ProportionInterval;\n}\n\nconst MutationsTable: FunctionComponent<MutationsTableProps> = ({ data, proportionInterval }) => {\n    const getHeaders = () => {\n        return [\n            {\n                name: 'Mutation',\n                sort: {\n                    compare: (a: string, b: string) => {\n                        return sortSubstitutionsAndDeletions(a, b);\n                    },\n                },\n            },\n            {\n                name: 'Type',\n                sort: true,\n            },\n            {\n                name: 'Count',\n                sort: true,\n            },\n            {\n                name: 'Proportion',\n                sort: true,\n                formatter: (cell: number) => formatProportion(cell),\n            },\n        ];\n    };\n\n    const tableData = getMutationsTableData(data, proportionInterval).map((row) => Object.values(row));\n\n    return <Table data={tableData} columns={getHeaders()} pagination={true} />;\n};\n\nexport default MutationsTable;\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchInsertions } from '../lapisApi/lapisApi';\nimport { type InsertionEntry, type LapisFilter, type SequenceType } from '../types';\nimport { Insertion } from '../utils/mutations';\n\nexport class FetchInsertionsOperator implements Operator<InsertionEntry> {\n    constructor(\n        private filter: LapisFilter,\n        private sequenceType: SequenceType,\n    ) {}\n\n    async evaluate(lapisUrl: string, signal?: AbortSignal): Promise<Dataset<InsertionEntry>> {\n        const insertions = (await fetchInsertions(lapisUrl, this.filter, this.sequenceType, signal)).data;\n\n        const content: InsertionEntry[] = insertions.map(({ count, insertedSymbols, sequenceName, position }) => ({\n            type: 'insertion',\n            mutation: new Insertion(sequenceName ?? undefined, position, insertedSymbols),\n            count,\n        }));\n\n        return { content };\n    }\n}\n","import { FetchInsertionsOperator } from '../operator/FetchInsertionsOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type SequenceType } from '../types';\n\nexport function queryInsertions(variant: LapisFilter, sequenceType: SequenceType, lapis: string, signal?: AbortSignal) {\n    const fetchData = new FetchInsertionsOperator(variant, sequenceType);\n    const sortData = new SortOperator(fetchData, (a, b) => {\n        if (a.mutation.segment !== b.mutation.segment) {\n            return (a.mutation.segment ?? '').localeCompare(b.mutation.segment ?? '');\n        }\n        return a.mutation.position - b.mutation.position;\n    });\n    return sortData.evaluate(lapis, signal);\n}\n","import { queryInsertions } from '../../query/queryInsertions';\nimport { querySubstitutionsOrDeletions } from '../../query/querySubstitutionsOrDeletions';\nimport {\n    type InsertionEntry,\n    type LapisFilter,\n    type MutationEntry,\n    type SubstitutionOrDeletionEntry,\n} from '../../types';\nimport { type DisplayedSegment } from '../components/SegmentSelector';\nimport { type DisplayedMutationType } from '../components/mutation-type-selector';\n\nexport async function queryMutationsData(\n    variant: LapisFilter,\n    sequenceType: 'nucleotide' | 'amino acid',\n    lapis: string,\n) {\n    const substitutionsOrDeletions = (await querySubstitutionsOrDeletions(variant, sequenceType, lapis)).content;\n    const insertions = (await queryInsertions(variant, sequenceType, lapis)).content;\n\n    return {\n        substitutionsOrDeletions,\n        insertions,\n    };\n}\n\nexport function filterMutationsData(\n    data: { insertions: InsertionEntry[]; substitutionsOrDeletions: SubstitutionOrDeletionEntry[] },\n    displayedSegments: DisplayedSegment[],\n    displayedMutationTypes: DisplayedMutationType[],\n) {\n    function bySelectedSegments(mutationEntry: MutationEntry) {\n        if (mutationEntry.mutation.segment === undefined) {\n            return true;\n        }\n        return displayedSegments.some(\n            (displayedSegment) =>\n                displayedSegment.segment === mutationEntry.mutation.segment && displayedSegment.checked,\n        );\n    }\n\n    const byDisplayedMutationTypes = (mutationEntry: SubstitutionOrDeletionEntry) => {\n        return displayedMutationTypes.some(\n            (displayedMutationType) =>\n                displayedMutationType.checked && displayedMutationType.type === mutationEntry.type,\n        );\n    };\n\n    const filteredSubstitutionsOrDeletions = data.substitutionsOrDeletions.filter(bySelectedSegments);\n\n    return {\n        insertions: data.insertions.filter(bySelectedSegments),\n        tableData: filteredSubstitutionsOrDeletions.filter(byDisplayedMutationTypes),\n        gridData: filteredSubstitutionsOrDeletions,\n    };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type Dispatch, type StateUpdater, useContext, useState } from 'preact/hooks';\n\nimport { getInsertionsTableData } from './getInsertionsTableData';\nimport { getMutationsTableData } from './getMutationsTableData';\nimport { MutationsGrid } from './mutations-grid';\nimport { InsertionsTable } from './mutations-insertions-table';\nimport MutationsTable from './mutations-table';\nimport { filterMutationsData, queryMutationsData } from './queryMutations';\nimport {\n    type InsertionEntry,\n    type LapisFilter,\n    type SequenceType,\n    type SubstitutionOrDeletionEntry,\n} from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { type DisplayedSegment, SegmentSelector, useDisplayedSegments } from '../components/SegmentSelector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { type DisplayedMutationType, MutationTypeSelector } from '../components/mutation-type-selector';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport type { ProportionInterval } from '../components/proportion-selector';\nimport { ProportionSelectorDropdown } from '../components/proportion-selector-dropdown';\nimport Tabs from '../components/tabs';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'table' | 'grid' | 'insertions';\n\nexport interface MutationsProps {\n    variant: LapisFilter;\n    sequenceType: SequenceType;\n    views: View[];\n}\n\nexport const Mutations: FunctionComponent<MutationsProps> = ({ variant, sequenceType, views }) => {\n    const lapis = useContext(LapisUrlContext);\n    const { data, error, isLoading } = useQuery(async () => {\n        return queryMutationsData(variant, sequenceType, lapis);\n    }, [variant, sequenceType, lapis]);\n\n    const headline = 'Mutations';\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <MutationsTabs mutationsData={data} sequenceType={sequenceType} views={views} />\n        </Headline>\n    );\n};\n\ntype MutationTabsProps = {\n    mutationsData: { insertions: InsertionEntry[]; substitutionsOrDeletions: SubstitutionOrDeletionEntry[] };\n    sequenceType: SequenceType;\n    views: View[];\n};\n\nconst MutationsTabs: FunctionComponent<MutationTabsProps> = ({ mutationsData, sequenceType, views }) => {\n    const [proportionInterval, setProportionInterval] = useState({ min: 0.05, max: 1 });\n\n    const [displayedSegments, setDisplayedSegments] = useDisplayedSegments(sequenceType);\n    const [displayedMutationTypes, setDisplayedMutationTypes] = useState<DisplayedMutationType[]>([\n        { label: 'Substitutions', checked: true, type: 'substitution' },\n        { label: 'Deletions', checked: true, type: 'deletion' },\n    ]);\n\n    const filteredData = filterMutationsData(mutationsData, displayedSegments, displayedMutationTypes);\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'table':\n                return {\n                    title: 'Table',\n                    content: <MutationsTable data={filteredData.tableData} proportionInterval={proportionInterval} />,\n                };\n            case 'grid':\n                return {\n                    title: 'Grid',\n                    content: (\n                        <MutationsGrid\n                            data={filteredData.gridData}\n                            sequenceType={sequenceType}\n                            proportionInterval={proportionInterval}\n                        />\n                    ),\n                };\n            case 'insertions':\n                return {\n                    title: 'Insertions',\n                    content: <InsertionsTable data={filteredData.insertions} />,\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    const toolbar = (activeTab: string) => (\n        <Toolbar\n            activeTab={activeTab}\n            displayedSegments={displayedSegments}\n            setDisplayedSegments={setDisplayedSegments}\n            displayedMutationTypes={displayedMutationTypes}\n            setDisplayedMutationTypes={setDisplayedMutationTypes}\n            filteredData={filteredData}\n            proportionInterval={proportionInterval}\n            setProportionInterval={setProportionInterval}\n        />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype ToolbarProps = {\n    activeTab: string;\n    displayedSegments: DisplayedSegment[];\n    setDisplayedSegments: (segments: DisplayedSegment[]) => void;\n    displayedMutationTypes: DisplayedMutationType[];\n    setDisplayedMutationTypes: (types: DisplayedMutationType[]) => void;\n    filteredData: { tableData: SubstitutionOrDeletionEntry[]; insertions: InsertionEntry[] };\n    proportionInterval: ProportionInterval;\n    setProportionInterval: Dispatch<StateUpdater<ProportionInterval>>;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    activeTab,\n    displayedSegments,\n    setDisplayedSegments,\n    displayedMutationTypes,\n    setDisplayedMutationTypes,\n    filteredData,\n    proportionInterval,\n    setProportionInterval,\n}) => {\n    return (\n        <div class='flex flex-row'>\n            <SegmentSelector displayedSegments={displayedSegments} setDisplayedSegments={setDisplayedSegments} />\n            {activeTab === 'Table' && (\n                <MutationTypeSelector\n                    setDisplayedMutationTypes={setDisplayedMutationTypes}\n                    displayedMutationTypes={displayedMutationTypes}\n                />\n            )}\n            {(activeTab === 'Table' || activeTab === 'Grid') && (\n                <>\n                    <ProportionSelectorDropdown\n                        proportionInterval={proportionInterval}\n                        setMinProportion={(min) => setProportionInterval((prev) => ({ ...prev, min }))}\n                        setMaxProportion={(max) => setProportionInterval((prev) => ({ ...prev, max }))}\n                        openDirection={'left'}\n                    />\n                    <CsvDownloadButton\n                        className='mx-1 btn btn-xs'\n                        getData={() => getMutationsTableData(filteredData.tableData, proportionInterval)}\n                        filename='substitutionsAndDeletions.csv'\n                    />\n                </>\n            )}\n            {activeTab === 'Insertions' && (\n                <CsvDownloadButton\n                    className='mx-1 btn btn-xs'\n                    getData={() => getInsertionsTableData(filteredData.insertions)}\n                    filename='insertions.csv'\n                />\n            )}\n            <Info className='mx-1' content='Info for mutations' />\n        </div>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { Mutations, type View } from '../../preact/mutations/mutations';\nimport { type LapisFilter, type SequenceType } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-mutations-component')\nexport class MutationsComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Object })\n    variant: LapisFilter = { displayName: '' };\n\n    @property({ type: String })\n    sequenceType: SequenceType = 'nucleotide';\n\n    @property({ type: Array })\n    views: View[] = ['table', 'grid'];\n\n    override render() {\n        return <Mutations variant={this.variant} sequenceType={this.sequenceType} views={this.views} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-mutations-component': MutationsComponent;\n    }\n}\n","import { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { type TemporalGranularity } from '../../types';\n\nexport function getPrevalenceOverTimeTableData(data: PrevalenceOverTimeData, granularity: TemporalGranularity) {\n    return data[0].content.map((row, rowNumber) => {\n        const otherColumns = data\n            .map((dataset) => ({\n                [`${dataset.displayName} prevalence`]: dataset.content[rowNumber].prevalence.toFixed(4),\n                [`${dataset.displayName} count`]: dataset.content[rowNumber].count,\n            }))\n            .reduce((acc, val) => ({ ...acc, ...val }), {});\n\n        return {\n            [granularity]: row.dateRange?.toString() ?? 'Unknown',\n            ...otherColumns,\n        };\n    });\n}\n","import { type Chart, type CoreScaleOptions, Scale } from 'chart.js';\n\nexport class LogitScale extends Scale {\n    static id = 'logit';\n\n    constructor(cfg: { id: string; type: string; ctx: CanvasRenderingContext2D; chart: Chart }) {\n        super(cfg);\n        this.min = 0.001;\n        this.max = 0.999;\n    }\n\n    override buildTicks() {\n        const tickValues = [this.min, 0.01, 0.1, 0.5, 0.9, 0.99, this.max];\n\n        this.ticks = tickValues.map((value) => ({ value }));\n        return this.ticks;\n    }\n\n    getLogit(value: number): number {\n        if (value <= 0) {\n            return -Infinity;\n        }\n        if (value >= 1) {\n            return Infinity;\n        }\n\n        return Math.log(value / (1 - value));\n    }\n\n    override getPixelForValue(value: number): number {\n        const logitMin = this.getLogit(this.min);\n        const logitMax = this.getLogit(this.max);\n\n        const logitValue = this.getLogit(value);\n\n        const decimal = (logitValue - logitMin) / (logitMax - logitMin);\n\n        return this.getPixelForDecimal(decimal);\n    }\n}\n\ndeclare module 'chart.js' {\n    export interface CartesianScaleTypeRegistry {\n        logit: {\n            options: CoreScaleOptions;\n        };\n    }\n}\n","// colorblind friendly colors taken from https://personal.sron.nl/~pault/\n\nconst ColorsRGB = {\n    indigo: [51, 34, 136],\n    green: [17, 119, 51],\n    cyan: [136, 204, 238],\n    teal: [68, 170, 153],\n    olive: [153, 153, 51],\n    sand: [221, 204, 119],\n    rose: [204, 102, 119],\n    wine: [136, 34, 85],\n    purple: [170, 68, 153],\n};\n\ntype GraphColor = keyof typeof ColorsRGB;\n\nexport const singleGraphColorRGBAById = (id: number, alpha = 1) => {\n    const keys = Object.keys(ColorsRGB) as GraphColor[];\n    const key = keys[id % keys.length];\n\n    return `rgba(${ColorsRGB[key].join(',')},${alpha})`;\n};\n\nexport const singleGraphColorRGBByName = (name: GraphColor, alpha = 1) => {\n    return `rgba(${ColorsRGB[name].join(',')},${alpha})`;\n};\n","// calculateWilsonInterval calculates the Wilson score interval for 95% confidence.\n//\n// This function is based on https://github.com/erikfox/wilson-interval, but without\n// high precision math.\n//\n// observed - number of observed positive outcomes\n// sample - number of experiments or size of the sample\nexport function wilson95PercentConfidenceInterval(observed: number, sample: number) {\n    const p = observed / sample;\n    const n = sample;\n    const z = 1.9599639715843482;\n\n    const numerator = p + (z * z) / (2 * n);\n    const w_plus_minus = z * Math.sqrt((p * (1 - p)) / n + (z * z) / (4 * (n * n)));\n    const denominator = 1 + (z * z) / n;\n\n    return {\n        lowerLimit: (numerator - w_plus_minus) / denominator,\n        upperLimit: (numerator + w_plus_minus) / denominator,\n    };\n}\n\nexport const confidenceIntervalDataLabel = (value: number, lowerLimit: number, upperLimit: number, prefix?: string) => {\n    const label = prefix ? `${prefix}: ` : '';\n\n    return `${label}${value.toFixed(3)} (${lowerLimit.toFixed(3)} - ${upperLimit.toFixed(3)})`;\n};\n\nexport type ConfidenceIntervalMethod = 'wilson' | 'none';\n","export type ScaleType = 'linear' | 'logarithmic' | 'logit';\n\nexport function getYAxisScale(scaleType: ScaleType) {\n    switch (scaleType) {\n        case 'linear': {\n            return { beginAtZero: true, type: 'linear' as const, min: 0, max: 1 };\n        }\n        case 'logarithmic': {\n            return { type: 'logarithmic' as const };\n        }\n        case 'logit':\n            return { type: 'logit' as const };\n        default:\n            return { beginAtZero: true, type: 'linear' as const };\n    }\n}\n","import { Chart, type ChartConfiguration, registerables, type TooltipItem } from 'chart.js';\nimport { BarWithErrorBar, BarWithErrorBarsController } from 'chartjs-chart-error-bars';\n\nimport { type PrevalenceOverTimeData, type PrevalenceOverTimeVariantData } from '../../query/queryPrevalenceOverTime';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport { type ConfidenceIntervalMethod, wilson95PercentConfidenceInterval } from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeBarChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n}\n\nChart.register(...registerables, LogitScale, BarWithErrorBarsController, BarWithErrorBar);\n\nconst PrevalenceOverTimeBarChart = ({\n    data,\n    yAxisScaleType,\n    confidenceIntervalMethod,\n}: PrevalenceOverTimeBarChartProps) => {\n    const config: ChartConfiguration = {\n        type: BarWithErrorBarsController.id,\n        data: {\n            labels: data[0]?.content.map((dateRange) => dateRange.dateRange?.toString() ?? 'Unknown') || [],\n            datasets: data.map((graphData, index) => datasets(graphData, index, confidenceIntervalMethod)),\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(confidenceIntervalMethod),\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nconst datasets = (\n    prevalenceOverTimeVariant: PrevalenceOverTimeVariantData,\n    index: number,\n    confidenceIntervalMethod: ConfidenceIntervalMethod,\n) => {\n    const generalConfig = {\n        borderWidth: 1,\n        pointRadius: 0,\n        label: prevalenceOverTimeVariant.displayName,\n        backgroundColor: singleGraphColorRGBAById(index, 0.3),\n        borderColor: singleGraphColorRGBAById(index),\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                data: prevalenceOverTimeVariant.content.map((dataPoint) => ({\n                    y: dataPoint.prevalence,\n                    yMin: wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).lowerLimit,\n                    yMax: wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).upperLimit,\n                })),\n            };\n        default:\n            return {\n                ...generalConfig,\n                data: prevalenceOverTimeVariant.content.map((dataPoint) => dataPoint.prevalence),\n            };\n    }\n};\n\nconst tooltip = (confidenceIntervalMethod: ConfidenceIntervalMethod) => {\n    const generalConfig = {\n        mode: 'index' as const,\n        intersect: false,\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                callbacks: {\n                    label: (context: TooltipItem<'barWithErrorBars'>) => {\n                        const value = context.dataset.data[context.dataIndex] as {\n                            y: number;\n                            yMin: number;\n                            yMax: number;\n                        };\n\n                        return `${context.dataset.label}: ${value.y.toFixed(3)} (${value.yMin.toFixed(3)} - ${value.yMax.toFixed(3)})`;\n                    },\n                },\n            };\n        default:\n            return generalConfig;\n    }\n};\n\nexport default PrevalenceOverTimeBarChart;\n","export var SECONDS_A_MINUTE = 60;\nexport var SECONDS_A_HOUR = SECONDS_A_MINUTE * 60;\nexport var SECONDS_A_DAY = SECONDS_A_HOUR * 24;\nexport var SECONDS_A_WEEK = SECONDS_A_DAY * 7;\nexport var MILLISECONDS_A_SECOND = 1e3;\nexport var MILLISECONDS_A_MINUTE = SECONDS_A_MINUTE * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_HOUR = SECONDS_A_HOUR * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_DAY = SECONDS_A_DAY * MILLISECONDS_A_SECOND;\nexport var MILLISECONDS_A_WEEK = SECONDS_A_WEEK * MILLISECONDS_A_SECOND; // English locales\n\nexport var MS = 'millisecond';\nexport var S = 'second';\nexport var MIN = 'minute';\nexport var H = 'hour';\nexport var D = 'day';\nexport var W = 'week';\nexport var M = 'month';\nexport var Q = 'quarter';\nexport var Y = 'year';\nexport var DATE = 'date';\nexport var FORMAT_DEFAULT = 'YYYY-MM-DDTHH:mm:ssZ';\nexport var INVALID_DATE_STRING = 'Invalid Date'; // regex\n\nexport var REGEX_PARSE = /^(\\d{4})[-/]?(\\d{1,2})?[-/]?(\\d{0,2})[Tt\\s]*(\\d{1,2})?:?(\\d{1,2})?:?(\\d{1,2})?[.:]?(\\d+)?$/;\nexport var REGEX_FORMAT = /\\[([^\\]]+)]|Y{1,4}|M{1,4}|D{1,2}|d{1,4}|H{1,2}|h{1,2}|a|A|m{1,2}|s{1,2}|Z{1,2}|SSS/g;","// English [en]\n// We don't need weekdaysShort, weekdaysMin, monthsShort in en.js locale\nexport default {\n  name: 'en',\n  weekdays: 'Sunday_Monday_Tuesday_Wednesday_Thursday_Friday_Saturday'.split('_'),\n  months: 'January_February_March_April_May_June_July_August_September_October_November_December'.split('_'),\n  ordinal: function ordinal(n) {\n    var s = ['th', 'st', 'nd', 'rd'];\n    var v = n % 100;\n    return \"[\" + n + (s[(v - 20) % 10] || s[v] || s[0]) + \"]\";\n  }\n};","import * as C from './constant';\n\nvar padStart = function padStart(string, length, pad) {\n  var s = String(string);\n  if (!s || s.length >= length) return string;\n  return \"\" + Array(length + 1 - s.length).join(pad) + string;\n};\n\nvar padZoneStr = function padZoneStr(instance) {\n  var negMinutes = -instance.utcOffset();\n  var minutes = Math.abs(negMinutes);\n  var hourOffset = Math.floor(minutes / 60);\n  var minuteOffset = minutes % 60;\n  return \"\" + (negMinutes <= 0 ? '+' : '-') + padStart(hourOffset, 2, '0') + \":\" + padStart(minuteOffset, 2, '0');\n};\n\nvar monthDiff = function monthDiff(a, b) {\n  // function from moment.js in order to keep the same result\n  if (a.date() < b.date()) return -monthDiff(b, a);\n  var wholeMonthDiff = (b.year() - a.year()) * 12 + (b.month() - a.month());\n  var anchor = a.clone().add(wholeMonthDiff, C.M);\n  var c = b - anchor < 0;\n  var anchor2 = a.clone().add(wholeMonthDiff + (c ? -1 : 1), C.M);\n  return +(-(wholeMonthDiff + (b - anchor) / (c ? anchor - anchor2 : anchor2 - anchor)) || 0);\n};\n\nvar absFloor = function absFloor(n) {\n  return n < 0 ? Math.ceil(n) || 0 : Math.floor(n);\n};\n\nvar prettyUnit = function prettyUnit(u) {\n  var special = {\n    M: C.M,\n    y: C.Y,\n    w: C.W,\n    d: C.D,\n    D: C.DATE,\n    h: C.H,\n    m: C.MIN,\n    s: C.S,\n    ms: C.MS,\n    Q: C.Q\n  };\n  return special[u] || String(u || '').toLowerCase().replace(/s$/, '');\n};\n\nvar isUndefined = function isUndefined(s) {\n  return s === undefined;\n};\n\nexport default {\n  s: padStart,\n  z: padZoneStr,\n  m: monthDiff,\n  a: absFloor,\n  p: prettyUnit,\n  u: isUndefined\n};","import * as C from './constant';\nimport en from './locale/en';\nimport U from './utils';\nvar L = 'en'; // global locale\n\nvar Ls = {}; // global loaded locale\n\nLs[L] = en;\nvar IS_DAYJS = '$isDayjsObject'; // eslint-disable-next-line no-use-before-define\n\nvar isDayjs = function isDayjs(d) {\n  return d instanceof Dayjs || !!(d && d[IS_DAYJS]);\n};\n\nvar parseLocale = function parseLocale(preset, object, isLocal) {\n  var l;\n  if (!preset) return L;\n\n  if (typeof preset === 'string') {\n    var presetLower = preset.toLowerCase();\n\n    if (Ls[presetLower]) {\n      l = presetLower;\n    }\n\n    if (object) {\n      Ls[presetLower] = object;\n      l = presetLower;\n    }\n\n    var presetSplit = preset.split('-');\n\n    if (!l && presetSplit.length > 1) {\n      return parseLocale(presetSplit[0]);\n    }\n  } else {\n    var name = preset.name;\n    Ls[name] = preset;\n    l = name;\n  }\n\n  if (!isLocal && l) L = l;\n  return l || !isLocal && L;\n};\n\nvar dayjs = function dayjs(date, c) {\n  if (isDayjs(date)) {\n    return date.clone();\n  } // eslint-disable-next-line no-nested-ternary\n\n\n  var cfg = typeof c === 'object' ? c : {};\n  cfg.date = date;\n  cfg.args = arguments; // eslint-disable-line prefer-rest-params\n\n  return new Dayjs(cfg); // eslint-disable-line no-use-before-define\n};\n\nvar wrapper = function wrapper(date, instance) {\n  return dayjs(date, {\n    locale: instance.$L,\n    utc: instance.$u,\n    x: instance.$x,\n    $offset: instance.$offset // todo: refactor; do not use this.$offset in you code\n\n  });\n};\n\nvar Utils = U; // for plugin use\n\nUtils.l = parseLocale;\nUtils.i = isDayjs;\nUtils.w = wrapper;\n\nvar parseDate = function parseDate(cfg) {\n  var date = cfg.date,\n      utc = cfg.utc;\n  if (date === null) return new Date(NaN); // null is invalid\n\n  if (Utils.u(date)) return new Date(); // today\n\n  if (date instanceof Date) return new Date(date);\n\n  if (typeof date === 'string' && !/Z$/i.test(date)) {\n    var d = date.match(C.REGEX_PARSE);\n\n    if (d) {\n      var m = d[2] - 1 || 0;\n      var ms = (d[7] || '0').substring(0, 3);\n\n      if (utc) {\n        return new Date(Date.UTC(d[1], m, d[3] || 1, d[4] || 0, d[5] || 0, d[6] || 0, ms));\n      }\n\n      return new Date(d[1], m, d[3] || 1, d[4] || 0, d[5] || 0, d[6] || 0, ms);\n    }\n  }\n\n  return new Date(date); // everything else\n};\n\nvar Dayjs = /*#__PURE__*/function () {\n  function Dayjs(cfg) {\n    this.$L = parseLocale(cfg.locale, null, true);\n    this.parse(cfg); // for plugin\n\n    this.$x = this.$x || cfg.x || {};\n    this[IS_DAYJS] = true;\n  }\n\n  var _proto = Dayjs.prototype;\n\n  _proto.parse = function parse(cfg) {\n    this.$d = parseDate(cfg);\n    this.init();\n  };\n\n  _proto.init = function init() {\n    var $d = this.$d;\n    this.$y = $d.getFullYear();\n    this.$M = $d.getMonth();\n    this.$D = $d.getDate();\n    this.$W = $d.getDay();\n    this.$H = $d.getHours();\n    this.$m = $d.getMinutes();\n    this.$s = $d.getSeconds();\n    this.$ms = $d.getMilliseconds();\n  } // eslint-disable-next-line class-methods-use-this\n  ;\n\n  _proto.$utils = function $utils() {\n    return Utils;\n  };\n\n  _proto.isValid = function isValid() {\n    return !(this.$d.toString() === C.INVALID_DATE_STRING);\n  };\n\n  _proto.isSame = function isSame(that, units) {\n    var other = dayjs(that);\n    return this.startOf(units) <= other && other <= this.endOf(units);\n  };\n\n  _proto.isAfter = function isAfter(that, units) {\n    return dayjs(that) < this.startOf(units);\n  };\n\n  _proto.isBefore = function isBefore(that, units) {\n    return this.endOf(units) < dayjs(that);\n  };\n\n  _proto.$g = function $g(input, get, set) {\n    if (Utils.u(input)) return this[get];\n    return this.set(set, input);\n  };\n\n  _proto.unix = function unix() {\n    return Math.floor(this.valueOf() / 1000);\n  };\n\n  _proto.valueOf = function valueOf() {\n    // timezone(hour) * 60 * 60 * 1000 => ms\n    return this.$d.getTime();\n  };\n\n  _proto.startOf = function startOf(units, _startOf) {\n    var _this = this;\n\n    // startOf -> endOf\n    var isStartOf = !Utils.u(_startOf) ? _startOf : true;\n    var unit = Utils.p(units);\n\n    var instanceFactory = function instanceFactory(d, m) {\n      var ins = Utils.w(_this.$u ? Date.UTC(_this.$y, m, d) : new Date(_this.$y, m, d), _this);\n      return isStartOf ? ins : ins.endOf(C.D);\n    };\n\n    var instanceFactorySet = function instanceFactorySet(method, slice) {\n      var argumentStart = [0, 0, 0, 0];\n      var argumentEnd = [23, 59, 59, 999];\n      return Utils.w(_this.toDate()[method].apply( // eslint-disable-line prefer-spread\n      _this.toDate('s'), (isStartOf ? argumentStart : argumentEnd).slice(slice)), _this);\n    };\n\n    var $W = this.$W,\n        $M = this.$M,\n        $D = this.$D;\n    var utcPad = \"set\" + (this.$u ? 'UTC' : '');\n\n    switch (unit) {\n      case C.Y:\n        return isStartOf ? instanceFactory(1, 0) : instanceFactory(31, 11);\n\n      case C.M:\n        return isStartOf ? instanceFactory(1, $M) : instanceFactory(0, $M + 1);\n\n      case C.W:\n        {\n          var weekStart = this.$locale().weekStart || 0;\n          var gap = ($W < weekStart ? $W + 7 : $W) - weekStart;\n          return instanceFactory(isStartOf ? $D - gap : $D + (6 - gap), $M);\n        }\n\n      case C.D:\n      case C.DATE:\n        return instanceFactorySet(utcPad + \"Hours\", 0);\n\n      case C.H:\n        return instanceFactorySet(utcPad + \"Minutes\", 1);\n\n      case C.MIN:\n        return instanceFactorySet(utcPad + \"Seconds\", 2);\n\n      case C.S:\n        return instanceFactorySet(utcPad + \"Milliseconds\", 3);\n\n      default:\n        return this.clone();\n    }\n  };\n\n  _proto.endOf = function endOf(arg) {\n    return this.startOf(arg, false);\n  };\n\n  _proto.$set = function $set(units, _int) {\n    var _C$D$C$DATE$C$M$C$Y$C;\n\n    // private set\n    var unit = Utils.p(units);\n    var utcPad = \"set\" + (this.$u ? 'UTC' : '');\n    var name = (_C$D$C$DATE$C$M$C$Y$C = {}, _C$D$C$DATE$C$M$C$Y$C[C.D] = utcPad + \"Date\", _C$D$C$DATE$C$M$C$Y$C[C.DATE] = utcPad + \"Date\", _C$D$C$DATE$C$M$C$Y$C[C.M] = utcPad + \"Month\", _C$D$C$DATE$C$M$C$Y$C[C.Y] = utcPad + \"FullYear\", _C$D$C$DATE$C$M$C$Y$C[C.H] = utcPad + \"Hours\", _C$D$C$DATE$C$M$C$Y$C[C.MIN] = utcPad + \"Minutes\", _C$D$C$DATE$C$M$C$Y$C[C.S] = utcPad + \"Seconds\", _C$D$C$DATE$C$M$C$Y$C[C.MS] = utcPad + \"Milliseconds\", _C$D$C$DATE$C$M$C$Y$C)[unit];\n    var arg = unit === C.D ? this.$D + (_int - this.$W) : _int;\n\n    if (unit === C.M || unit === C.Y) {\n      // clone is for badMutable plugin\n      var date = this.clone().set(C.DATE, 1);\n      date.$d[name](arg);\n      date.init();\n      this.$d = date.set(C.DATE, Math.min(this.$D, date.daysInMonth())).$d;\n    } else if (name) this.$d[name](arg);\n\n    this.init();\n    return this;\n  };\n\n  _proto.set = function set(string, _int2) {\n    return this.clone().$set(string, _int2);\n  };\n\n  _proto.get = function get(unit) {\n    return this[Utils.p(unit)]();\n  };\n\n  _proto.add = function add(number, units) {\n    var _this2 = this,\n        _C$MIN$C$H$C$S$unit;\n\n    number = Number(number); // eslint-disable-line no-param-reassign\n\n    var unit = Utils.p(units);\n\n    var instanceFactorySet = function instanceFactorySet(n) {\n      var d = dayjs(_this2);\n      return Utils.w(d.date(d.date() + Math.round(n * number)), _this2);\n    };\n\n    if (unit === C.M) {\n      return this.set(C.M, this.$M + number);\n    }\n\n    if (unit === C.Y) {\n      return this.set(C.Y, this.$y + number);\n    }\n\n    if (unit === C.D) {\n      return instanceFactorySet(1);\n    }\n\n    if (unit === C.W) {\n      return instanceFactorySet(7);\n    }\n\n    var step = (_C$MIN$C$H$C$S$unit = {}, _C$MIN$C$H$C$S$unit[C.MIN] = C.MILLISECONDS_A_MINUTE, _C$MIN$C$H$C$S$unit[C.H] = C.MILLISECONDS_A_HOUR, _C$MIN$C$H$C$S$unit[C.S] = C.MILLISECONDS_A_SECOND, _C$MIN$C$H$C$S$unit)[unit] || 1; // ms\n\n    var nextTimeStamp = this.$d.getTime() + number * step;\n    return Utils.w(nextTimeStamp, this);\n  };\n\n  _proto.subtract = function subtract(number, string) {\n    return this.add(number * -1, string);\n  };\n\n  _proto.format = function format(formatStr) {\n    var _this3 = this;\n\n    var locale = this.$locale();\n    if (!this.isValid()) return locale.invalidDate || C.INVALID_DATE_STRING;\n    var str = formatStr || C.FORMAT_DEFAULT;\n    var zoneStr = Utils.z(this);\n    var $H = this.$H,\n        $m = this.$m,\n        $M = this.$M;\n    var weekdays = locale.weekdays,\n        months = locale.months,\n        meridiem = locale.meridiem;\n\n    var getShort = function getShort(arr, index, full, length) {\n      return arr && (arr[index] || arr(_this3, str)) || full[index].slice(0, length);\n    };\n\n    var get$H = function get$H(num) {\n      return Utils.s($H % 12 || 12, num, '0');\n    };\n\n    var meridiemFunc = meridiem || function (hour, minute, isLowercase) {\n      var m = hour < 12 ? 'AM' : 'PM';\n      return isLowercase ? m.toLowerCase() : m;\n    };\n\n    var matches = function matches(match) {\n      switch (match) {\n        case 'YY':\n          return String(_this3.$y).slice(-2);\n\n        case 'YYYY':\n          return Utils.s(_this3.$y, 4, '0');\n\n        case 'M':\n          return $M + 1;\n\n        case 'MM':\n          return Utils.s($M + 1, 2, '0');\n\n        case 'MMM':\n          return getShort(locale.monthsShort, $M, months, 3);\n\n        case 'MMMM':\n          return getShort(months, $M);\n\n        case 'D':\n          return _this3.$D;\n\n        case 'DD':\n          return Utils.s(_this3.$D, 2, '0');\n\n        case 'd':\n          return String(_this3.$W);\n\n        case 'dd':\n          return getShort(locale.weekdaysMin, _this3.$W, weekdays, 2);\n\n        case 'ddd':\n          return getShort(locale.weekdaysShort, _this3.$W, weekdays, 3);\n\n        case 'dddd':\n          return weekdays[_this3.$W];\n\n        case 'H':\n          return String($H);\n\n        case 'HH':\n          return Utils.s($H, 2, '0');\n\n        case 'h':\n          return get$H(1);\n\n        case 'hh':\n          return get$H(2);\n\n        case 'a':\n          return meridiemFunc($H, $m, true);\n\n        case 'A':\n          return meridiemFunc($H, $m, false);\n\n        case 'm':\n          return String($m);\n\n        case 'mm':\n          return Utils.s($m, 2, '0');\n\n        case 's':\n          return String(_this3.$s);\n\n        case 'ss':\n          return Utils.s(_this3.$s, 2, '0');\n\n        case 'SSS':\n          return Utils.s(_this3.$ms, 3, '0');\n\n        case 'Z':\n          return zoneStr;\n        // 'ZZ' logic below\n\n        default:\n          break;\n      }\n\n      return null;\n    };\n\n    return str.replace(C.REGEX_FORMAT, function (match, $1) {\n      return $1 || matches(match) || zoneStr.replace(':', '');\n    }); // 'ZZ'\n  };\n\n  _proto.utcOffset = function utcOffset() {\n    // Because a bug at FF24, we're rounding the timezone offset around 15 minutes\n    // https://github.com/moment/moment/pull/1871\n    return -Math.round(this.$d.getTimezoneOffset() / 15) * 15;\n  };\n\n  _proto.diff = function diff(input, units, _float) {\n    var _this4 = this;\n\n    var unit = Utils.p(units);\n    var that = dayjs(input);\n    var zoneDelta = (that.utcOffset() - this.utcOffset()) * C.MILLISECONDS_A_MINUTE;\n    var diff = this - that;\n\n    var getMonth = function getMonth() {\n      return Utils.m(_this4, that);\n    };\n\n    var result;\n\n    switch (unit) {\n      case C.Y:\n        result = getMonth() / 12;\n        break;\n\n      case C.M:\n        result = getMonth();\n        break;\n\n      case C.Q:\n        result = getMonth() / 3;\n        break;\n\n      case C.W:\n        result = (diff - zoneDelta) / C.MILLISECONDS_A_WEEK;\n        break;\n\n      case C.D:\n        result = (diff - zoneDelta) / C.MILLISECONDS_A_DAY;\n        break;\n\n      case C.H:\n        result = diff / C.MILLISECONDS_A_HOUR;\n        break;\n\n      case C.MIN:\n        result = diff / C.MILLISECONDS_A_MINUTE;\n        break;\n\n      case C.S:\n        result = diff / C.MILLISECONDS_A_SECOND;\n        break;\n\n      default:\n        result = diff; // milliseconds\n\n        break;\n    }\n\n    return _float ? result : Utils.a(result);\n  };\n\n  _proto.daysInMonth = function daysInMonth() {\n    return this.endOf(C.M).$D;\n  };\n\n  _proto.$locale = function $locale() {\n    // get locale object\n    return Ls[this.$L];\n  };\n\n  _proto.locale = function locale(preset, object) {\n    if (!preset) return this.$L;\n    var that = this.clone();\n    var nextLocaleName = parseLocale(preset, object, true);\n    if (nextLocaleName) that.$L = nextLocaleName;\n    return that;\n  };\n\n  _proto.clone = function clone() {\n    return Utils.w(this.$d, this);\n  };\n\n  _proto.toDate = function toDate() {\n    return new Date(this.valueOf());\n  };\n\n  _proto.toJSON = function toJSON() {\n    return this.isValid() ? this.toISOString() : null;\n  };\n\n  _proto.toISOString = function toISOString() {\n    // ie 8 return\n    // new Dayjs(this.valueOf() + this.$d.getTimezoneOffset() * 60000)\n    // .format('YYYY-MM-DDTHH:mm:ss.SSS[Z]')\n    return this.$d.toISOString();\n  };\n\n  _proto.toString = function toString() {\n    return this.$d.toUTCString();\n  };\n\n  return Dayjs;\n}();\n\nvar proto = Dayjs.prototype;\ndayjs.prototype = proto;\n[['$ms', C.MS], ['$s', C.S], ['$m', C.MIN], ['$H', C.H], ['$W', C.D], ['$M', C.M], ['$y', C.Y], ['$D', C.DATE]].forEach(function (g) {\n  proto[g[1]] = function (input) {\n    return this.$g(input, g[0], g[1]);\n  };\n});\n\ndayjs.extend = function (plugin, option) {\n  if (!plugin.$i) {\n    // install plugin only once\n    plugin(option, Dayjs, dayjs);\n    plugin.$i = true;\n  }\n\n  return dayjs;\n};\n\ndayjs.locale = parseLocale;\ndayjs.isDayjs = isDayjs;\n\ndayjs.unix = function (timestamp) {\n  return dayjs(timestamp * 1e3);\n};\n\ndayjs.en = Ls[L];\ndayjs.Ls = Ls;\ndayjs.p = {};\nexport default dayjs;","import { FORMAT_DEFAULT } from '../../constant';\nexport default (function (o, c) {\n  // locale needed later\n  var proto = c.prototype;\n  var oldFormat = proto.format;\n\n  proto.format = function (formatStr) {\n    var _this = this;\n\n    var locale = this.$locale();\n\n    if (!this.isValid()) {\n      return oldFormat.bind(this)(formatStr);\n    }\n\n    var utils = this.$utils();\n    var str = formatStr || FORMAT_DEFAULT;\n    var result = str.replace(/\\[([^\\]]+)]|Q|wo|ww|w|WW|W|zzz|z|gggg|GGGG|Do|X|x|k{1,2}|S/g, function (match) {\n      switch (match) {\n        case 'Q':\n          return Math.ceil((_this.$M + 1) / 3);\n\n        case 'Do':\n          return locale.ordinal(_this.$D);\n\n        case 'gggg':\n          return _this.weekYear();\n\n        case 'GGGG':\n          return _this.isoWeekYear();\n\n        case 'wo':\n          return locale.ordinal(_this.week(), 'W');\n        // W for week\n\n        case 'w':\n        case 'ww':\n          return utils.s(_this.week(), match === 'w' ? 1 : 2, '0');\n\n        case 'W':\n        case 'WW':\n          return utils.s(_this.isoWeek(), match === 'W' ? 1 : 2, '0');\n\n        case 'k':\n        case 'kk':\n          return utils.s(String(_this.$H === 0 ? 24 : _this.$H), match === 'k' ? 1 : 2, '0');\n\n        case 'X':\n          return Math.floor(_this.$d.getTime() / 1000);\n\n        case 'x':\n          return _this.$d.getTime();\n\n        case 'z':\n          return \"[\" + _this.offsetName() + \"]\";\n\n        case 'zzz':\n          return \"[\" + _this.offsetName('long') + \"]\";\n\n        default:\n          return match;\n      }\n    });\n    return oldFormat.bind(this)(result);\n  };\n});","import { D, W, Y } from '../../constant';\nvar isoWeekPrettyUnit = 'isoweek';\nexport default (function (o, c, d) {\n  var getYearFirstThursday = function getYearFirstThursday(year, isUtc) {\n    var yearFirstDay = (isUtc ? d.utc : d)().year(year).startOf(Y);\n    var addDiffDays = 4 - yearFirstDay.isoWeekday();\n\n    if (yearFirstDay.isoWeekday() > 4) {\n      addDiffDays += 7;\n    }\n\n    return yearFirstDay.add(addDiffDays, D);\n  };\n\n  var getCurrentWeekThursday = function getCurrentWeekThursday(ins) {\n    return ins.add(4 - ins.isoWeekday(), D);\n  };\n\n  var proto = c.prototype;\n\n  proto.isoWeekYear = function () {\n    var nowWeekThursday = getCurrentWeekThursday(this);\n    return nowWeekThursday.year();\n  };\n\n  proto.isoWeek = function (week) {\n    if (!this.$utils().u(week)) {\n      return this.add((week - this.isoWeek()) * 7, D);\n    }\n\n    var nowWeekThursday = getCurrentWeekThursday(this);\n    var diffWeekThursday = getYearFirstThursday(this.isoWeekYear(), this.$u);\n    return nowWeekThursday.diff(diffWeekThursday, W) + 1;\n  };\n\n  proto.isoWeekday = function (week) {\n    if (!this.$utils().u(week)) {\n      return this.day(this.day() % 7 ? week : week - 7);\n    }\n\n    return this.day() || 7;\n  };\n\n  var oldStartOf = proto.startOf;\n\n  proto.startOf = function (units, startOf) {\n    var utils = this.$utils();\n    var isStartOf = !utils.u(startOf) ? startOf : true;\n    var unit = utils.p(units);\n\n    if (unit === isoWeekPrettyUnit) {\n      return isStartOf ? this.date(this.date() - (this.isoWeekday() - 1)).startOf('day') : this.date(this.date() - 1 - (this.isoWeekday() - 1) + 7).endOf('day');\n    }\n\n    return oldStartOf.bind(this)(units, startOf);\n  };\n});","import dayjs from 'dayjs/esm';\nimport advancedFormat from 'dayjs/esm/plugin/advancedFormat';\nimport isoWeek from 'dayjs/esm/plugin/isoWeek';\n\ndayjs.extend(isoWeek);\ndayjs.extend(advancedFormat);\n\nexport class TemporalCache {\n    private yearMonthDayCache = new Map<string, YearMonthDay>();\n    private yearWeekCache = new Map<string, YearWeek>();\n    private yearMonthCache = new Map<string, YearMonth>();\n    private yearCache = new Map<string, Year>();\n\n    private constructor() {}\n\n    getYearMonthDay(s: string): YearMonthDay {\n        if (!this.yearMonthDayCache.has(s)) {\n            this.yearMonthDayCache.set(s, YearMonthDay.parse(s, this));\n        }\n        return this.yearMonthDayCache.get(s)!;\n    }\n\n    getYearMonth(s: string): YearMonth {\n        if (!this.yearMonthCache.has(s)) {\n            this.yearMonthCache.set(s, YearMonth.parse(s, this));\n        }\n        return this.yearMonthCache.get(s)!;\n    }\n\n    getYearWeek(s: string): YearWeek {\n        if (!this.yearWeekCache.has(s)) {\n            this.yearWeekCache.set(s, YearWeek.parse(s, this));\n        }\n        return this.yearWeekCache.get(s)!;\n    }\n\n    getYear(s: string): Year {\n        if (!this.yearCache.has(s)) {\n            this.yearCache.set(s, Year.parse(s, this));\n        }\n        return this.yearCache.get(s)!;\n    }\n\n    private static instance = new TemporalCache();\n\n    static getInstance(): TemporalCache {\n        return this.instance;\n    }\n}\n\nexport class YearMonthDay {\n    readonly date;\n    readonly dayjs;\n\n    constructor(\n        readonly yearNumber: number,\n        readonly monthNumber: number,\n        readonly dayNumber: number,\n        readonly cache: TemporalCache,\n    ) {\n        this.date = new Date(this.yearNumber, this.monthNumber - 1, this.dayNumber);\n        this.dayjs = dayjs(this.date);\n    }\n\n    get text(): string {\n        return this.dayjs.format('YYYY-MM-DD');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.yearNumber}`);\n    }\n\n    get month(): YearMonth {\n        return this.cache.getYearMonth(this.dayjs.format('YYYY-MM'));\n    }\n\n    get week(): YearWeek {\n        return this.cache.getYearWeek(this.dayjs.format('GGGG-WW'));\n    }\n\n    addDays(days: number): YearMonthDay {\n        const date = this.dayjs.add(days, 'day');\n        const s = date.format('YYYY-MM-DD');\n        return this.cache.getYearMonthDay(s);\n    }\n\n    minus(other: YearMonthDay): number {\n        return this.dayjs.diff(other.dayjs, 'day');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearMonthDay {\n        const [year, month, day] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearMonthDay(year, month, day, cache);\n    }\n}\n\nexport class YearWeek {\n    constructor(\n        readonly isoYearNumber: number,\n        readonly isoWeekNumber: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY-WW');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstDay(): YearMonthDay {\n        // \"The first week of the year, hence, always contains 4 January.\" https://en.wikipedia.org/wiki/ISO_week_date\n        const firstDay = dayjs()\n            .year(this.isoYearNumber)\n            .month(1)\n            .date(4)\n            .isoWeek(this.isoWeekNumber)\n            .startOf('isoWeek');\n        return this.cache.getYearMonthDay(firstDay.format('YYYY-MM-DD'));\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.isoYearNumber}`);\n    }\n\n    addWeeks(weeks: number): YearWeek {\n        const date = this.firstDay.dayjs.add(weeks, 'week');\n        const s = date.format('YYYY-WW');\n        return this.cache.getYearWeek(s);\n    }\n\n    minus(other: YearWeek): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'week');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearWeek {\n        const [year, week] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearWeek(year, week, cache);\n    }\n}\n\nexport class YearMonth {\n    constructor(\n        readonly yearNumber: number,\n        readonly monthNumber: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY-MM');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstDay(): YearMonthDay {\n        return this.cache.getYearMonthDay(dayjs(`${this.yearNumber}-${this.monthNumber}-01`).format('YYYY-MM-DD'));\n    }\n\n    get year(): Year {\n        return this.cache.getYear(`${this.yearNumber}`);\n    }\n\n    addMonths(months: number): YearMonth {\n        const date = this.firstDay.dayjs.add(months, 'month');\n        const s = date.format('YYYY-MM');\n        return this.cache.getYearMonth(s);\n    }\n\n    minus(other: YearMonth): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'month');\n    }\n\n    static parse(s: string, cache: TemporalCache): YearMonth {\n        const [year, month] = s.split('-').map((s) => parseInt(s, 10));\n        return new YearMonth(year, month, cache);\n    }\n}\n\nexport class Year {\n    constructor(\n        readonly year: number,\n        readonly cache: TemporalCache,\n    ) {}\n\n    get text(): string {\n        return this.firstDay.dayjs.format('YYYY');\n    }\n\n    toString(): string {\n        return this.text;\n    }\n\n    get firstMonth(): YearMonth {\n        return this.cache.getYearMonth(`${this.year}-01`);\n    }\n\n    get firstDay(): YearMonthDay {\n        return this.firstMonth.firstDay;\n    }\n\n    addYears(years: number): Year {\n        const date = this.firstDay.dayjs.add(years, 'year');\n        const s = date.format('YYYY');\n        return this.cache.getYear(s);\n    }\n\n    minus(other: Year): number {\n        return this.firstDay.dayjs.diff(other.firstDay.dayjs, 'year');\n    }\n\n    static parse(s: string, cache: TemporalCache): Year {\n        const year = parseInt(s, 10);\n        return new Year(year, cache);\n    }\n}\n\nexport type Temporal = YearMonthDay | YearWeek | YearMonth | Year;\n\nexport function generateAllDaysInRange(start: YearMonthDay, end: YearMonthDay): YearMonthDay[] {\n    const days = [];\n    const daysInBetween = end.minus(start);\n    for (let i = 0; i <= daysInBetween; i++) {\n        days.push(start.addDays(i));\n    }\n    return days;\n}\n\nexport function generateAllWeeksInRange(start: YearWeek, end: YearWeek): YearWeek[] {\n    const weeks = [];\n    const weeksInBetween = end.minus(start);\n    for (let i = 0; i <= weeksInBetween; i++) {\n        weeks.push(start.addWeeks(i));\n    }\n    return weeks;\n}\n\nexport function generateAllMonthsInRange(start: YearMonth, end: YearMonth): YearMonth[] {\n    const months = [];\n    const monthsInBetween = end.minus(start);\n    for (let i = 0; i <= monthsInBetween; i++) {\n        months.push(start.addMonths(i));\n    }\n    return months;\n}\n\nexport function generateAllYearsInRange(start: Year, end: Year): Year[] {\n    const years = [];\n    const yearsInBetween = end.minus(start);\n    for (let i = 0; i <= yearsInBetween; i++) {\n        years.push(start.addYears(i));\n    }\n    return years;\n}\n\nexport function generateAllInRange(start: Temporal | null, end: Temporal | null): Temporal[] {\n    if (start === null || end === null) {\n        return [];\n    }\n    if (start instanceof YearMonthDay && end instanceof YearMonthDay) {\n        return generateAllDaysInRange(start, end);\n    }\n    if (start instanceof YearWeek && end instanceof YearWeek) {\n        return generateAllWeeksInRange(start, end);\n    }\n    if (start instanceof YearMonth && end instanceof YearMonth) {\n        return generateAllMonthsInRange(start, end);\n    }\n    if (start instanceof Year && end instanceof Year) {\n        return generateAllYearsInRange(start, end);\n    }\n    throw new Error(`Invalid arguments: start and end must be of the same type: ${start}, ${end}`);\n}\n\nexport function minusTemporal(a: Temporal, b: Temporal): number {\n    if (a instanceof YearMonthDay && b instanceof YearMonthDay) {\n        return a.minus(b);\n    }\n    if (a instanceof YearWeek && b instanceof YearWeek) {\n        return a.minus(b);\n    }\n    if (a instanceof YearMonth && b instanceof YearMonth) {\n        return a.minus(b);\n    }\n    if (a instanceof Year && b instanceof Year) {\n        return a.minus(b);\n    }\n    throw new Error(`Cannot compare ${a} and ${b}`);\n}\n\nexport function compareTemporal(a: Temporal | null, b: Temporal | null): number {\n    if (a === null) {\n        return 1;\n    }\n    if (b === null) {\n        return -1;\n    }\n    const diff = minusTemporal(a, b);\n    if (diff < 0) {\n        return -1;\n    }\n    if (diff > 0) {\n        return 1;\n    }\n    return 0;\n}\n\nexport function getMinMaxTemporal(values: Iterable<Temporal | null>): [Temporal, Temporal] | null {\n    let min = null;\n    let max = null;\n    for (const value of values) {\n        if (value === null) {\n            continue;\n        }\n        if (min === null || compareTemporal(value, min) < 0) {\n            min = value;\n        }\n        if (max === null || compareTemporal(value, max) > 0) {\n            max = value;\n        }\n    }\n    if (min === null || max === null) {\n        return null;\n    }\n    return [min, max];\n}\n\nexport function addUnit(temporal: Temporal, amount: number): Temporal {\n    if (temporal instanceof YearMonthDay) {\n        return temporal.addDays(amount);\n    }\n    if (temporal instanceof YearWeek) {\n        return temporal.addWeeks(amount);\n    }\n    if (temporal instanceof YearMonth) {\n        return temporal.addMonths(amount);\n    }\n    if (temporal instanceof Year) {\n        return temporal.addYears(amount);\n    }\n    throw new Error(`Invalid argument: ${temporal}`);\n}\n","import { type LapisFilter } from '../types';\n\nexport function getMinMaxNumber(values: Iterable<number>): [number, number] | null {\n    let min = null;\n    let max = null;\n    for (const value of values) {\n        if (min === null || value < min) {\n            min = value;\n        }\n        if (max === null || value > max) {\n            max = value;\n        }\n    }\n    if (min === null || max === null) {\n        return null;\n    }\n    return [min, max];\n}\n\nexport function mapLapisFilterToUrlParams(filter: LapisFilter): URLSearchParams {\n    const params = Object.entries(filter).map(([key, value]) => [key, stringifyLapisFilterValue(value)]);\n\n    return new URLSearchParams(params);\n}\n\nfunction stringifyLapisFilterValue(value: LapisFilter[string]) {\n    if (value === null) {\n        return 'null';\n    }\n    switch (typeof value) {\n        case 'boolean':\n            return value ? 'true' : 'false';\n        case 'number':\n            return value.toString();\n        case 'string':\n            return value;\n    }\n}\n","import { Chart, type ChartConfiguration, registerables } from 'chart.js';\n\nimport { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { addUnit, minusTemporal } from '../../utils/temporal';\nimport { getMinMaxNumber } from '../../utils/utils';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeBubbleChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst PrevalenceOverTimeBubbleChart = ({ data, yAxisScaleType }: PrevalenceOverTimeBubbleChartProps) => {\n    const firstDate = data[0].content[0].dateRange!;\n    const total = data.map((graphData) => graphData.content.map((dataPoint) => dataPoint.total)).flat();\n    const [minTotal, maxTotal] = getMinMaxNumber(total)!;\n    const scaleBubble = (value: number) => {\n        return ((value - minTotal) / (maxTotal - minTotal)) * 4.5 + 0.5;\n    };\n\n    const config: ChartConfiguration = {\n        type: 'bubble',\n        data: {\n            datasets: data.map((graphData, index) => ({\n                label: graphData.displayName,\n                data: graphData.content\n                    .filter((dataPoint) => dataPoint.dateRange !== null)\n                    .map((dataPoint) => ({\n                        x: minusTemporal(dataPoint.dateRange!, firstDate),\n                        y: dataPoint.prevalence,\n                        r: scaleBubble(dataPoint.total),\n                    })),\n                borderWidth: 1,\n                pointRadius: 0,\n                backgroundColor: singleGraphColorRGBAById(index, 0.3),\n                borderColor: singleGraphColorRGBAById(index),\n            })),\n        },\n        options: {\n            animation: false,\n            scales: {\n                x: {\n                    ticks: {\n                        callback: (value) => addUnit(firstDate, value as number).toString(),\n                    },\n                },\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: {\n                    mode: 'index',\n                    intersect: false,\n                    callbacks: {\n                        title: (context) => {\n                            const dataset = data[context[0].datasetIndex!];\n                            const dataPoint = dataset.content[context[0].dataIndex!];\n                            return dataPoint.dateRange?.toString();\n                        },\n                        label: (context) => {\n                            const dataset = data[context.datasetIndex!];\n                            const dataPoint = dataset.content[context.dataIndex!];\n\n                            const percentage = (dataPoint.prevalence * 100).toFixed(2);\n                            const count = dataPoint.count.toFixed(0);\n                            const total = dataPoint.total.toFixed(0);\n\n                            return `${dataset.displayName}: ${percentage}%, ${count}/${total} samples`;\n                        },\n                    },\n                },\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nexport default PrevalenceOverTimeBubbleChart;\n","import { Chart, type ChartConfiguration, registerables } from 'chart.js';\nimport { type TooltipItem } from 'chart.js/dist/types';\n\nimport { type PrevalenceOverTimeData, type PrevalenceOverTimeVariantData } from '../../query/queryPrevalenceOverTime';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBAById } from '../shared/charts/colors';\nimport {\n    confidenceIntervalDataLabel,\n    type ConfidenceIntervalMethod,\n    wilson95PercentConfidenceInterval,\n} from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface PrevalenceOverTimeLineChartProps {\n    data: PrevalenceOverTimeData;\n    yAxisScaleType: ScaleType;\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst PrevalenceOverTimeLineChart = ({\n    data,\n    yAxisScaleType,\n    confidenceIntervalMethod,\n}: PrevalenceOverTimeLineChartProps) => {\n    const datasets = data.map((graphData, index) => getDataset(graphData, index, confidenceIntervalMethod)).flat();\n    const labels = data[0]?.content.map((dateRange) => dateRange.dateRange?.toString() ?? 'Unknown') || [];\n\n    const config: ChartConfiguration = {\n        type: 'line',\n        data: {\n            labels,\n            datasets,\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(confidenceIntervalMethod),\n            },\n        },\n    };\n\n    return <GsChart configuration={config} />;\n};\n\nconst getDataset = (\n    prevalenceOverTimeVariant: PrevalenceOverTimeVariantData,\n    dataIndex: number,\n    confidenceIntervalMethod: ConfidenceIntervalMethod,\n) => {\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return [\n                getDatasetCIUpper(prevalenceOverTimeVariant, dataIndex),\n                getDatasetLine(prevalenceOverTimeVariant, dataIndex),\n                getDatasetCILower(prevalenceOverTimeVariant, dataIndex),\n            ].flat();\n        default:\n            return getDatasetLine(prevalenceOverTimeVariant, dataIndex);\n    }\n};\n\nconst getDatasetCIUpper = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: `${prevalenceOverTimeVariant.displayName} CI upper`,\n    data: prevalenceOverTimeVariant.content.map(\n        (dataPoint) => wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).upperLimit,\n    ),\n    borderWidth: 0,\n    pointRadius: 0,\n    fill: '+1',\n    backgroundColor: singleGraphColorRGBAById(dataIndex, 0.3),\n});\n\nconst getDatasetCILower = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: `${prevalenceOverTimeVariant.displayName} CI lower`,\n    data: prevalenceOverTimeVariant.content.map(\n        (dataPoint) => wilson95PercentConfidenceInterval(dataPoint.count, dataPoint.total).lowerLimit,\n    ),\n    borderWidth: 0,\n    pointRadius: 0,\n    fill: '-1',\n    backgroundColor: singleGraphColorRGBAById(dataIndex, 0.3),\n});\n\nconst getDatasetLine = (prevalenceOverTimeVariant: PrevalenceOverTimeVariantData, dataIndex: number) => ({\n    label: prevalenceOverTimeVariant.displayName,\n    data: prevalenceOverTimeVariant.content.map((dataPoint) => dataPoint.prevalence),\n    borderWidth: 1,\n    pointRadius: 0,\n    borderColor: singleGraphColorRGBAById(dataIndex),\n    backgroundColor: singleGraphColorRGBAById(dataIndex),\n});\n\nconst tooltip = (confidenceIntervalMethod?: ConfidenceIntervalMethod) => {\n    const generalConfig = {\n        mode: 'index' as const,\n        intersect: false,\n    };\n\n    switch (confidenceIntervalMethod) {\n        case 'wilson':\n            return {\n                ...generalConfig,\n                filter: ({ datasetIndex }: TooltipItem<'line'>) => {\n                    return datasetIndex % 3 === 1;\n                },\n                callbacks: {\n                    label: (context: TooltipItem<'line'>) => {\n                        if (context.datasetIndex % 3 === 1) {\n                            const value = context.dataset.data[context.dataIndex];\n                            const ciLower = context.dataset.data[context.dataIndex - 1];\n                            const ciUpper = context.dataset.data[context.dataIndex + 1];\n\n                            if (\n                                typeof value !== 'number' ||\n                                typeof ciLower !== 'number' ||\n                                typeof ciUpper !== 'number'\n                            ) {\n                                return '';\n                            }\n\n                            return confidenceIntervalDataLabel(value, ciLower, ciUpper, context.dataset.label);\n                        }\n                        return context.dataset.label;\n                    },\n                },\n            };\n        default:\n            return generalConfig;\n    }\n};\n\nexport default PrevalenceOverTimeLineChart;\n","import { getPrevalenceOverTimeTableData } from './getPrevalenceOverTimeTableData';\nimport { type PrevalenceOverTimeData } from '../../query/queryPrevalenceOverTime';\nimport { type TemporalGranularity } from '../../types';\nimport { Table } from '../components/table';\nimport { formatProportion } from '../shared/table/formatProportion';\n\ninterface PrevalenceOverTimeTableProps {\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n}\n\nconst PrevalenceOverTimeTable = ({ data, granularity }: PrevalenceOverTimeTableProps) => {\n    const getSplitColumns = (data: PrevalenceOverTimeData) => {\n        return data.map((dataset) => ({\n            name: dataset.displayName,\n            columns: [\n                {\n                    name: 'prevalence',\n                    sort: true,\n                    formatter: (cell: number) => formatProportion(cell),\n                },\n                {\n                    name: 'count',\n                    sort: true,\n                },\n            ],\n        }));\n    };\n\n    const getColumns = (data: PrevalenceOverTimeData) => [\n        {\n            name: granularity,\n            sort: true,\n        },\n        ...getSplitColumns(data),\n    ];\n\n    const getData = (data: PrevalenceOverTimeData, granularity: TemporalGranularity) => {\n        const dataByHeader = getPrevalenceOverTimeTableData(data, granularity);\n        return Object.values(dataByHeader).map((row) => Object.values(row));\n    };\n\n    return <Table data={getData(data, granularity)} columns={getColumns(data)} pagination={false} />;\n};\n\nexport default PrevalenceOverTimeTable;\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { type MappedNumber, type NumberFields } from '../utils/type-utils';\n\nexport type DivisionOperatorResult<\n    KeyField extends keyof ValueObject,\n    ValueObject,\n    ResultField extends string,\n    NumeratorField extends string,\n    DenominatorField extends string,\n> = { [P in KeyField]: ValueObject[KeyField] } & MappedNumber<ResultField> &\n    MappedNumber<NumeratorField> &\n    MappedNumber<DenominatorField>;\n\nexport class DivisionOperator<\n    ValueObject,\n    KeyField extends keyof ValueObject,\n    ValueField extends NumberFields<ValueObject>,\n    ResultField extends string,\n    NumeratorField extends string,\n    DenominatorField extends string,\n> implements Operator<DivisionOperatorResult<KeyField, ValueObject, ResultField, NumeratorField, DenominatorField>>\n{\n    constructor(\n        private numerator: Operator<ValueObject>,\n        private denominator: Operator<ValueObject>,\n        private keyField: KeyField,\n        private valueField: ValueField,\n        private resultField: ResultField,\n        private numeratorField: NumeratorField,\n        private denominatorField: DenominatorField,\n    ) {}\n\n    async evaluate(\n        lapis: string,\n        signal?: AbortSignal,\n    ): Promise<Dataset<DivisionOperatorResult<KeyField, ValueObject, ResultField, NumeratorField, DenominatorField>>> {\n        const numeratorEvaluated = await this.numerator.evaluate(lapis, signal);\n        const denominatorEvaluated = await this.denominator.evaluate(lapis, signal);\n\n        const numeratorMap = new Map<ValueObject[KeyField], ValueObject[ValueField]>();\n        numeratorEvaluated.content.forEach((row) => {\n            numeratorMap.set(row[this.keyField], row[this.valueField]);\n        });\n\n        const content = denominatorEvaluated.content.map((row) => {\n            const numeratorValue = numeratorMap.get(row[this.keyField]) ?? 0;\n            return {\n                [this.keyField]: row[this.keyField],\n                [this.numeratorField]: numeratorValue as number,\n                [this.denominatorField]: row[this.valueField] as number,\n                [this.resultField]: (numeratorValue as number) / (row[this.valueField] as number),\n            } as { [P in KeyField]: ValueObject[KeyField] } & MappedNumber<ResultField> &\n                MappedNumber<NumeratorField> &\n                MappedNumber<DenominatorField>;\n        });\n\n        return { content };\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\nimport { fetchAggregated } from '../lapisApi/lapisApi';\nimport { type AggregatedItem } from '../lapisApi/lapisTypes';\nimport { type LapisFilter } from '../types';\n\nexport class FetchAggregatedOperator<Fields extends Record<string, unknown>>\n    implements\n        Operator<\n            Fields & {\n                count: number;\n            }\n        >\n{\n    constructor(\n        private filter: LapisFilter,\n        private fields: string[],\n    ) {}\n\n    async evaluate(lapisUrl: string, signal?: AbortSignal): Promise<Dataset<Fields & { count: number }>> {\n        const aggregatedResponse = (\n            await fetchAggregated(\n                lapisUrl,\n                {\n                    ...this.filter,\n                    fields: this.fields,\n                },\n                signal,\n            )\n        ).data;\n\n        if (isFieldsArrayWithCount<Fields & { count: number }>(aggregatedResponse)) {\n            return {\n                content: aggregatedResponse,\n            };\n        }\n\n        throw new Error('Aggregated response does not have count');\n    }\n}\n\nfunction isFieldsArrayWithCount<T>(data: AggregatedItem[]): data is (T & { count: number })[] {\n    return data.every((item) => typeof item === 'object' && 'count' in item && typeof item.count === 'number');\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class FillMissingOperator<Data, KeyToFill extends keyof Data> implements Operator<Data> {\n    constructor(\n        private child: Operator<Data>,\n        private keyField: KeyToFill,\n        private getMinMaxFn: (values: Iterable<Data[KeyToFill]>) => [Data[KeyToFill], Data[KeyToFill]] | null,\n        private getAllRequiredKeysFn: (min: Data[KeyToFill], max: Data[KeyToFill]) => Data[KeyToFill][],\n        private defaultValueFn: (key: Data[KeyToFill]) => Data,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<Data>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const existingKeys = new Set(childEvaluated.content.map((row) => row[this.keyField]));\n        const minMax = this.getMinMaxFn(existingKeys);\n        if (minMax === null) {\n            return childEvaluated;\n        }\n        const [min, max] = minMax;\n        const requiredKeys = this.getAllRequiredKeysFn(min, max);\n        const content = childEvaluated.content;\n        for (const key of requiredKeys) {\n            if (!existingKeys.has(key)) {\n                content.push(this.defaultValueFn(key));\n            }\n        }\n        return { content };\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class GroupByOperator<Data, AggregationResult, KeyToGroupBy extends keyof Data>\n    implements Operator<AggregationResult>\n{\n    constructor(\n        private child: Operator<Data>,\n        private field: KeyToGroupBy,\n        private aggregate: (values: Data[]) => AggregationResult,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<AggregationResult>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const grouped = new Map<Data[KeyToGroupBy], Data[]>();\n        for (const row of childEvaluated.content) {\n            const key = row[this.field];\n            if (!grouped.has(key)) {\n                grouped.set(key, []);\n            }\n            grouped.get(key)!.push(row);\n        }\n        const result = new Array<AggregationResult>();\n        for (const [, values] of grouped) {\n            result.push(this.aggregate(values));\n        }\n\n        return {\n            content: result,\n        };\n    }\n}\n","import { GroupByOperator } from './GroupByOperator';\nimport { type Operator } from './Operator';\nimport { type NumberFields } from '../utils/type-utils';\n\ntype Result<Data, KeyToGroupBy extends keyof Data, KeyToSumBy extends keyof Data> = {\n    [P in KeyToGroupBy | KeyToSumBy]: P extends KeyToGroupBy ? Data[KeyToGroupBy] : number;\n};\n\nexport class GroupByAndSumOperator<\n    Data,\n    KeyToGroupBy extends keyof Data,\n    KeySoSumBy extends NumberFields<Data>,\n> extends GroupByOperator<Data, Result<Data, KeyToGroupBy, KeySoSumBy>, KeyToGroupBy> {\n    constructor(child: Operator<Data>, groupByField: KeyToGroupBy, sumField: KeySoSumBy) {\n        super(child, groupByField, (values: Data[]) => {\n            let n = 0;\n            for (const value of values) {\n                n += value[sumField] as number;\n            }\n            return {\n                [groupByField]: values[0][groupByField],\n                [sumField]: n,\n            } as Result<Data, KeyToGroupBy, KeySoSumBy>;\n        });\n    }\n}\n","import { type Dataset } from './Dataset';\nimport { type Operator } from './Operator';\n\nexport class MapOperator<S, T> implements Operator<T> {\n    constructor(\n        private child: Operator<S>,\n        private func: (value: S) => T,\n    ) {}\n\n    async evaluate(lapis: string, signal?: AbortSignal): Promise<Dataset<T>> {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        return {\n            content: childEvaluated.content.map(this.func),\n        };\n    }\n}\n","import { type Operator } from './Operator';\n\nexport class SlidingOperator<Data, AggregationResult> implements Operator<AggregationResult> {\n    constructor(\n        private child: Operator<Data>,\n        private windowSize: number,\n        private aggregate: (values: Data[]) => AggregationResult,\n    ) {\n        if (windowSize < 1) {\n            throw new Error('Window size must be at least 1');\n        }\n    }\n\n    async evaluate(lapis: string, signal?: AbortSignal) {\n        const childEvaluated = await this.child.evaluate(lapis, signal);\n        const content = new Array<AggregationResult>();\n        const numberOfWindows = Math.max(childEvaluated.content.length - this.windowSize, 0) + 1;\n        for (let i = 0; i < numberOfWindows; i++) {\n            content.push(this.aggregate(childEvaluated.content.slice(i, i + this.windowSize)));\n        }\n        return { content };\n    }\n}\n","import { DivisionOperator } from '../operator/DivisionOperator';\nimport { FetchAggregatedOperator } from '../operator/FetchAggregatedOperator';\nimport { FillMissingOperator } from '../operator/FillMissingOperator';\nimport { GroupByAndSumOperator } from '../operator/GroupByAndSumOperator';\nimport { MapOperator } from '../operator/MapOperator';\nimport { SlidingOperator } from '../operator/SlidingOperator';\nimport { SortOperator } from '../operator/SortOperator';\nimport { type LapisFilter, type NamedLapisFilter, type TemporalGranularity } from '../types';\nimport {\n    compareTemporal,\n    generateAllInRange,\n    getMinMaxTemporal,\n    type Temporal,\n    TemporalCache,\n} from '../utils/temporal';\n\nexport type PrevalenceOverTimeData = PrevalenceOverTimeVariantData[];\n\nexport type PrevalenceOverTimeVariantData = {\n    displayName: string;\n    content: { count: number; prevalence: number; total: number; dateRange: Temporal | null }[];\n};\n\nexport function queryPrevalenceOverTime(\n    numeratorFilter: NamedLapisFilter | NamedLapisFilter[],\n    denominatorFilter: NamedLapisFilter,\n    granularity: TemporalGranularity,\n    smoothingWindow: number,\n    lapis: string,\n    signal?: AbortSignal,\n): Promise<PrevalenceOverTimeData> {\n    const numeratorFilters = makeArray(numeratorFilter);\n\n    const denominatorData = fetchAndPrepare(getFilter(denominatorFilter), granularity, smoothingWindow);\n    const subQueries = numeratorFilters.map(async (namedLapisFilter) => {\n        const { displayName, ...filter } = namedLapisFilter;\n        const numeratorData = fetchAndPrepare(filter, granularity, smoothingWindow);\n        const divide = new DivisionOperator(\n            numeratorData,\n            denominatorData,\n            'dateRange',\n            'count',\n            'prevalence',\n            'count',\n            'total',\n        );\n        const dataset = await divide.evaluate(lapis, signal);\n        return {\n            displayName,\n            content: dataset.content,\n        };\n    });\n    return Promise.all(subQueries);\n}\n\nfunction getFilter(filter: NamedLapisFilter) {\n    // eslint-disable-next-line @typescript-eslint/no-unused-vars\n    const { displayName, ...filterWithoutDisplayName } = filter;\n    return filterWithoutDisplayName;\n}\n\nfunction makeArray<T>(arrayOrSingleItem: T | T[]) {\n    if (Array.isArray(arrayOrSingleItem)) {\n        return arrayOrSingleItem;\n    }\n    return [arrayOrSingleItem];\n}\n\nfunction fetchAndPrepare(filter: LapisFilter, granularity: TemporalGranularity, smoothingWindow: number) {\n    const fetchData = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(filter, ['date']);\n    const mapData = new MapOperator(fetchData, (d) => mapDateToGranularityRange(d, granularity));\n    const groupByData = new GroupByAndSumOperator(mapData, 'dateRange', 'count');\n    const fillData = new FillMissingOperator(\n        groupByData,\n        'dateRange',\n        getMinMaxTemporal,\n        generateAllInRange,\n        (key) => ({ dateRange: key, count: 0 }),\n    );\n    const sortData = new SortOperator(fillData, dateRangeCompare);\n\n    return smoothingWindow >= 1 ? new SlidingOperator(sortData, smoothingWindow, averageSmoothing) : sortData;\n}\n\nfunction mapDateToGranularityRange(d: { date: string | null; count: number }, granularity: TemporalGranularity) {\n    let dateRange: Temporal | null = null;\n    if (d.date !== null) {\n        const date = TemporalCache.getInstance().getYearMonthDay(d.date);\n        switch (granularity) {\n            case 'day':\n                dateRange = date;\n                break;\n            case 'week':\n                dateRange = date.week;\n                break;\n            case 'month':\n                dateRange = date.month;\n                break;\n            case 'year':\n                dateRange = date.year;\n                break;\n        }\n    }\n    return {\n        dateRange,\n        count: d.count,\n    };\n}\n\nfunction dateRangeCompare(a: { dateRange: Temporal | null }, b: { dateRange: Temporal | null }) {\n    if (a.dateRange === null) {\n        return 1;\n    }\n    if (b.dateRange === null) {\n        return -1;\n    }\n    return compareTemporal(a.dateRange, b.dateRange);\n}\n\nfunction averageSmoothing(slidingWindow: { dateRange: Temporal | null; count: number }[]) {\n    const average = slidingWindow.reduce((acc, curr) => acc + curr.count, 0) / slidingWindow.length;\n    const centerIndex = Math.floor(slidingWindow.length / 2);\n    return { dateRange: slidingWindow[centerIndex].dateRange, count: average };\n}\n","import { type FunctionComponent } from 'preact';\nimport { type JSXInternal } from 'preact/src/jsx';\n\nexport interface SelectProps {\n    items: { label: string; value: string; disabled?: boolean }[];\n    selected: string;\n    onChange: JSXInternal.GenericEventHandler<HTMLSelectElement>;\n    selectStyle?: string;\n}\n\nexport const Select: FunctionComponent<SelectProps> = ({ items, selected, onChange, selectStyle }) => {\n    return (\n        <select class={`select select-bordered ${selectStyle}`} value={selected} onChange={onChange}>\n            {items.map((item) => (\n                <option key={item.value} value={item.value} disabled={item.disabled}>\n                    {item.label}\n                </option>\n            ))}\n        </select>\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { Select } from './select';\nimport type { ConfidenceIntervalMethod } from '../shared/charts/confideceInterval';\n\ntype ConfidenceIntervalSelectorProps = {\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n    setConfidenceIntervalMethod: (method: ConfidenceIntervalMethod) => void;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n};\n\nexport const ConfidenceIntervalSelector: FunctionComponent<ConfidenceIntervalSelectorProps> = ({\n    confidenceIntervalMethod,\n    setConfidenceIntervalMethod,\n    confidenceIntervalMethods,\n}) => {\n    if (confidenceIntervalMethods.length === 0) {\n        return null;\n    }\n\n    const items = [\n        { label: 'Confidence interval method', value: 'none', disabled: true },\n        ...confidenceIntervalMethods.concat('none').map((method) => {\n            switch (method) {\n                case 'wilson':\n                    return { label: 'Wilson, 95% CI', value: 'wilson' };\n                case 'none':\n                    return { label: 'None', value: 'none' };\n            }\n        }),\n    ];\n\n    return (\n        <Select\n            items={items}\n            selected={confidenceIntervalMethod === undefined ? 'none' : confidenceIntervalMethod}\n            onChange={(event: Event) => {\n                const select = event.target as HTMLSelectElement;\n                const value = select.value as ConfidenceIntervalMethod;\n                setConfidenceIntervalMethod(value);\n            }}\n            selectStyle={'select-xs select-bordered'}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\n\nimport { Select } from './select';\nimport type { ScaleType } from '../shared/charts/getYAxisScale';\n\nexport type ScalingSelectorProps = {\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    className?: string;\n};\n\nexport const ScalingSelector: FunctionComponent<ScalingSelectorProps> = ({\n    yAxisScaleType,\n    setYAxisScaleType,\n    className,\n}) => {\n    const items = [\n        { label: 'y axis scaling type', value: 'none', disabled: true },\n        { label: 'Linear', value: 'linear' },\n        { label: 'Logarithmic', value: 'logarithmic' },\n        { label: 'Logit', value: 'logit' },\n    ];\n\n    return (\n        <Select\n            items={items}\n            selected={yAxisScaleType}\n            onChange={(event: Event) => {\n                const select = event.target as HTMLSelectElement;\n                const value = select.value as ScaleType;\n                setYAxisScaleType(value);\n            }}\n            selectStyle={`${className} select-xs select-bordered`}\n        />\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport { getPrevalenceOverTimeTableData } from './getPrevalenceOverTimeTableData';\nimport PrevalenceOverTimeBarChart from './prevalence-over-time-bar-chart';\nimport PrevalenceOverTimeBubbleChart from './prevalence-over-time-bubble-chart';\nimport PrevalenceOverTimeLineChart from './prevalence-over-time-line-chart';\nimport PrevalenceOverTimeTable from './prevalence-over-time-table';\nimport { type PrevalenceOverTimeData, queryPrevalenceOverTime } from '../../query/queryPrevalenceOverTime';\nimport { type NamedLapisFilter, type TemporalGranularity } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ConfidenceIntervalSelector } from '../components/confidence-interval-selector';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { ScalingSelector } from '../components/scaling-selector';\nimport Tabs from '../components/tabs';\nimport { type ConfidenceIntervalMethod } from '../shared/charts/confideceInterval';\nimport { type ScaleType } from '../shared/charts/getYAxisScale';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'bar' | 'line' | 'bubble' | 'table';\n\nexport interface PrevalenceOverTimeProps {\n    numerator: NamedLapisFilter | NamedLapisFilter[];\n    denominator: NamedLapisFilter;\n    granularity: TemporalGranularity;\n    smoothingWindow: number;\n    views: View[];\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n}\n\nexport const PrevalenceOverTime: FunctionComponent<PrevalenceOverTimeProps> = ({\n    numerator,\n    denominator,\n    granularity,\n    smoothingWindow,\n    views,\n    confidenceIntervalMethods,\n}) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const { data, error, isLoading } = useQuery(\n        () => queryPrevalenceOverTime(numerator, denominator, granularity, smoothingWindow, lapis),\n        [lapis, numerator, denominator, granularity, smoothingWindow],\n    );\n\n    const headline = 'Prevalence over time';\n\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <PrevalenceOverTimeTabs\n                views={views}\n                data={data}\n                granularity={granularity}\n                confidenceIntervalMethods={confidenceIntervalMethods}\n            />\n        </Headline>\n    );\n};\n\ntype PrevalenceOverTimeTabsProps = {\n    views: View[];\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n};\n\nconst PrevalenceOverTimeTabs: FunctionComponent<PrevalenceOverTimeTabsProps> = ({\n    views,\n    data,\n    granularity,\n    confidenceIntervalMethods,\n}) => {\n    const [yAxisScaleType, setYAxisScaleType] = useState<ScaleType>('linear');\n    const [confidenceIntervalMethod, setConfidenceIntervalMethod] = useState<ConfidenceIntervalMethod>(\n        confidenceIntervalMethods.length > 0 ? confidenceIntervalMethods[0] : 'none',\n    );\n\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'bar':\n                return {\n                    title: 'Bar',\n                    content: (\n                        <PrevalenceOverTimeBarChart\n                            data={data}\n                            yAxisScaleType={yAxisScaleType}\n                            confidenceIntervalMethod={confidenceIntervalMethod}\n                        />\n                    ),\n                };\n            case 'line':\n                return {\n                    title: 'Line',\n                    content: (\n                        <PrevalenceOverTimeLineChart\n                            data={data}\n                            yAxisScaleType={yAxisScaleType}\n                            confidenceIntervalMethod={confidenceIntervalMethod}\n                        />\n                    ),\n                };\n            case 'bubble':\n                return {\n                    title: 'Bubble',\n                    content: <PrevalenceOverTimeBubbleChart data={data} yAxisScaleType={yAxisScaleType} />,\n                };\n            case 'table':\n                return { title: 'Table', content: <PrevalenceOverTimeTable data={data} granularity={granularity} /> };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    const toolbar = (activeTab: string) => (\n        <Toolbar\n            activeTab={activeTab}\n            yAxisScaleType={yAxisScaleType}\n            setYAxisScaleType={setYAxisScaleType}\n            data={data}\n            granularity={granularity}\n            confidenceIntervalMethods={confidenceIntervalMethods}\n            confidenceIntervalMethod={confidenceIntervalMethod}\n            setConfidenceIntervalMethod={setConfidenceIntervalMethod}\n        />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype ToolbarProps = {\n    activeTab: string;\n    data: PrevalenceOverTimeData;\n    granularity: TemporalGranularity;\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    confidenceIntervalMethods: ConfidenceIntervalMethod[];\n    confidenceIntervalMethod: ConfidenceIntervalMethod;\n    setConfidenceIntervalMethod: (confidenceIntervalMethod: ConfidenceIntervalMethod) => void;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({\n    activeTab,\n    yAxisScaleType,\n    setYAxisScaleType,\n    confidenceIntervalMethods,\n    confidenceIntervalMethod,\n    setConfidenceIntervalMethod,\n    data,\n    granularity,\n}) => {\n    return (\n        <div class='flex'>\n            {activeTab !== 'Table' && (\n                <ScalingSelector yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n            )}\n            {(activeTab === 'Bar' || activeTab === 'Line') && (\n                <ConfidenceIntervalSelector\n                    confidenceIntervalMethods={confidenceIntervalMethods}\n                    confidenceIntervalMethod={confidenceIntervalMethod}\n                    setConfidenceIntervalMethod={setConfidenceIntervalMethod}\n                />\n            )}\n            <CsvDownloadButton\n                className='mx-1 btn btn-xs'\n                getData={() => getPrevalenceOverTimeTableData(data, granularity)}\n                filename='prevalence-over-time.csv'\n            />\n            <Info className='ml-1' content='Info for prevalence over time' />\n        </div>\n    );\n};\n\nexport default PrevalenceOverTime;\n","import { customElement, property } from 'lit/decorators.js';\n\nimport PrevalenceOverTime, { type View } from '../../preact/prevalenceOverTime/prevalence-over-time';\nimport { type ConfidenceIntervalMethod } from '../../preact/shared/charts/confideceInterval';\nimport { type NamedLapisFilter, type TemporalGranularity } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n@customElement('gs-prevalence-over-time')\nexport class PrevalenceOverTimeComponent extends PreactLitAdapterWithGridJsStyles {\n    @property({ type: Object })\n    numerator: NamedLapisFilter | NamedLapisFilter[] = { displayName: '' };\n\n    @property({ type: Object })\n    denominator: NamedLapisFilter = { displayName: '' };\n\n    @property({ type: String })\n    granularity: TemporalGranularity = 'day';\n\n    @property({ type: Number })\n    smoothingWindow: number = 0;\n\n    @property({ type: Array })\n    views: View[] = ['bar', 'line', 'bubble', 'table'];\n\n    @property({ type: Array })\n    confidenceIntervalMethods: ConfidenceIntervalMethod[] = ['wilson'];\n\n    override render() {\n        return (\n            <PrevalenceOverTime\n                numerator={this.numerator}\n                denominator={this.denominator}\n                granularity={this.granularity}\n                smoothingWindow={this.smoothingWindow}\n                views={this.views}\n                confidenceIntervalMethods={this.confidenceIntervalMethods}\n            />\n        );\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-prevalence-over-time': PrevalenceOverTimeComponent;\n    }\n}\n","import { Chart, type ChartConfiguration, registerables, type TooltipItem } from 'chart.js';\n\nimport { type YearMonthDay } from '../../utils/temporal';\nimport GsChart from '../components/chart';\nimport { LogitScale } from '../shared/charts/LogitScale';\nimport { singleGraphColorRGBByName } from '../shared/charts/colors';\nimport { confidenceIntervalDataLabel } from '../shared/charts/confideceInterval';\nimport { getYAxisScale, type ScaleType } from '../shared/charts/getYAxisScale';\n\ninterface RelativeGrowthAdvantageChartData {\n    t: YearMonthDay[];\n    proportion: number[];\n    ciLower: number[];\n    ciUpper: number[];\n    observed: number[];\n    params: {\n        fd: {\n            value: number;\n            ciLower: number;\n            ciUpper: number;\n        };\n    };\n}\n\ninterface RelativeGrowthAdvantageChartProps {\n    data: RelativeGrowthAdvantageChartData;\n    yAxisScaleType: ScaleType;\n}\n\nChart.register(...registerables, LogitScale);\n\nconst RelativeGrowthAdvantageChart = ({ data, yAxisScaleType }: RelativeGrowthAdvantageChartProps) => {\n    const config: ChartConfiguration = {\n        type: 'line',\n        data: {\n            labels: data.t,\n            datasets: datasets(data),\n        },\n        options: {\n            animation: false,\n            scales: {\n                y: getYAxisScale(yAxisScaleType),\n            },\n            plugins: {\n                legend: {\n                    display: false,\n                },\n                tooltip: tooltip(),\n            },\n        },\n    };\n\n    return (\n        <>\n            <GsChart configuration={config} />\n            <div>\n                Advantage: {(data.params.fd.value * 100).toFixed(2)}% ({(data.params.fd.ciLower * 100).toFixed(2)}% -{' '}\n                {(data.params.fd.ciUpper * 100).toFixed(2)}%)\n            </div>\n        </>\n    );\n};\n\nconst datasets = (data: RelativeGrowthAdvantageChartData) => {\n    return [\n        {\n            type: 'line' as const,\n            label: 'Prevalence',\n            data: data.proportion,\n            borderWidth: 1,\n            pointRadius: 0,\n            borderColor: singleGraphColorRGBByName('indigo'),\n            backgroundColor: singleGraphColorRGBByName('indigo'),\n        },\n        {\n            type: 'line' as const,\n            label: 'CI Lower',\n            data: data.ciLower,\n            borderWidth: 1,\n            pointRadius: 0,\n            fill: '+1',\n            backgroundColor: singleGraphColorRGBByName('indigo', 0.3),\n        },\n        {\n            type: 'line' as const,\n            label: 'CI Upper',\n            data: data.ciUpper,\n            borderWidth: 1,\n            pointRadius: 0,\n            fill: '-1',\n            backgroundColor: singleGraphColorRGBByName('indigo', 0.3),\n        },\n        {\n            type: 'scatter' as const,\n            label: 'Observed',\n            data: data.observed,\n            pointBackgroundColor: singleGraphColorRGBByName('green'),\n            pointRadius: 2,\n        },\n    ];\n};\n\nconst tooltip = () => {\n    return {\n        mode: 'index' as const,\n        intersect: false,\n        filter: ({ datasetIndex }: TooltipItem<'line'>) => {\n            return datasetIndex !== 1 && datasetIndex !== 2;\n        },\n        callbacks: {\n            label: (context: TooltipItem<'line'>) => {\n                switch (context.datasetIndex) {\n                    case 0: {\n                        const value = context.dataset.data[context.dataIndex];\n                        const ciLower = context.dataset.data[context.dataIndex + 1];\n                        const ciUpper = context.dataset.data[context.dataIndex + 2];\n                        if (typeof value !== 'number' || typeof ciLower !== 'number' || typeof ciUpper !== 'number') {\n                            return '';\n                        }\n                        return confidenceIntervalDataLabel(value, ciLower, ciUpper, context.dataset.label);\n                    }\n\n                    case 3: {\n                        const value = context.dataset.data[context.dataIndex];\n                        if (typeof value !== 'number') {\n                            return '';\n                        }\n                        return `Observed: ${value.toFixed(3)}`;\n                    }\n                    default:\n                        return '';\n                }\n            },\n        },\n    };\n};\n\nexport default RelativeGrowthAdvantageChart;\n","import { FetchAggregatedOperator } from '../operator/FetchAggregatedOperator';\nimport { MapOperator } from '../operator/MapOperator';\nimport { type LapisFilter } from '../types';\nimport { getMinMaxTemporal, TemporalCache, type YearMonthDay } from '../utils/temporal';\n\nexport type RelativeGrowthAdvantageData = Awaited<ReturnType<typeof queryRelativeGrowthAdvantage>>;\n\nexport async function queryRelativeGrowthAdvantage(\n    numerator: LapisFilter,\n    denominator: LapisFilter,\n    generationTime: number,\n    lapis: string,\n    signal?: AbortSignal,\n) {\n    const fetchNumerator = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(numerator, ['date']);\n    const fetchDenominator = new FetchAggregatedOperator<{\n        date: string | null;\n    }>(denominator, ['date']);\n    const mapNumerator = new MapOperator(fetchNumerator, toYearMonthDay);\n    const mapDenominator = new MapOperator(fetchDenominator, toYearMonthDay);\n    const [numeratorData, denominatorData] = await Promise.all([\n        mapNumerator.evaluate(lapis, signal),\n        mapDenominator.evaluate(lapis, signal),\n    ]);\n    const minMaxDate = getMinMaxTemporal(denominatorData.content.map((d) => d.date));\n    if (!minMaxDate) {\n        return null;\n    }\n    const [minDate, maxDate] = minMaxDate as [YearMonthDay, YearMonthDay];\n    const numeratorCounts = new Map<YearMonthDay, number>();\n    numeratorData.content.forEach((d) => {\n        if (d.date) {\n            numeratorCounts.set(d.date, d.count);\n        }\n    });\n    const denominatorCounts = new Map<YearMonthDay, number>();\n    const requestData = {\n        t: [] as number[],\n        n: [] as number[],\n        k: [] as number[],\n    };\n    denominatorData.content.forEach((d) => {\n        if (d.date) {\n            denominatorCounts.set(d.date, d.count);\n            const t = d.date.minus(minDate);\n            requestData.t.push(t);\n            requestData.n.push(d.count);\n            requestData.k.push(numeratorCounts.get(d.date) ?? 0);\n        }\n    });\n    const requestPayload = {\n        config: {\n            alpha: 0.95,\n            generationTime,\n            initialCasesVariant: 1,\n            initialCasesWildtype: 1,\n            reproductionNumberWildtype: 1,\n            tStart: 0,\n            tEnd: maxDate.minus(minDate),\n        },\n        data: requestData,\n    };\n    const response = await fetch('https://cov-spectrum.org/api/v2/computed/model/chen2021Fitness', {\n        method: 'POST',\n        headers: {\n            'Content-Type': 'application/json',\n        },\n        body: JSON.stringify(requestPayload),\n        signal,\n    });\n    const responseData = (await response.json()) as {\n        estimatedAbsoluteNumbers: {\n            t: number[];\n            variantCases: number[];\n            wildtypeCases: number[];\n        };\n        estimatedProportions: {\n            t: number[];\n            proportion: number[];\n            ciLower: number[];\n            ciUpper: number[];\n        };\n        params: {\n            a: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            fc: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            fd: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n            t0: {\n                value: number;\n                ciLower: number;\n                ciUpper: number;\n            };\n        };\n    };\n    const transformed = {\n        ...responseData,\n        estimatedProportions: {\n            ...responseData.estimatedProportions,\n            t: responseData.estimatedProportions.t.map((t) => minDate.addDays(t)),\n        },\n    };\n    const observedProportions = transformed.estimatedProportions.t.map(\n        (t) => (numeratorCounts.get(t) ?? 0) / (denominatorCounts.get(t) ?? 0),\n    );\n\n    return {\n        ...transformed,\n        observedProportions,\n    };\n}\n\nfunction toYearMonthDay(d: { date: string | null; count: number }) {\n    const temporalCache = TemporalCache.getInstance();\n    return {\n        date: d.date ? temporalCache.getYearMonthDay(d.date) : null,\n        count: d.count,\n    };\n}\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useState } from 'preact/hooks';\n\nimport RelativeGrowthAdvantageChart from './relative-growth-advantage-chart';\nimport {\n    queryRelativeGrowthAdvantage,\n    type RelativeGrowthAdvantageData,\n} from '../../query/queryRelativeGrowthAdvantage';\nimport { type LapisFilter } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { ScalingSelector } from '../components/scaling-selector';\nimport Tabs from '../components/tabs';\nimport { type ScaleType } from '../shared/charts/getYAxisScale';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'line';\n\nexport interface RelativeGrowthAdvantageProps {\n    numerator: LapisFilter;\n    denominator: LapisFilter;\n    generationTime: number;\n    views: View[];\n}\n\nexport const RelativeGrowthAdvantage: FunctionComponent<RelativeGrowthAdvantageProps> = ({\n    numerator,\n    denominator,\n    generationTime,\n    views,\n}) => {\n    const lapis = useContext(LapisUrlContext);\n    const [yAxisScaleType, setYAxisScaleType] = useState<ScaleType>('linear');\n\n    const { data, error, isLoading } = useQuery(\n        () => queryRelativeGrowthAdvantage(numerator, denominator, generationTime, lapis),\n        [lapis, numerator, denominator, generationTime, views],\n    );\n\n    const headline = 'Relative growth advantage';\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <RelativeGrowthAdvantageTabs\n                data={data}\n                yAxisScaleType={yAxisScaleType}\n                setYAxisScaleType={setYAxisScaleType}\n                views={views}\n            />\n        </Headline>\n    );\n};\n\ntype RelativeGrowthAdvantageTabsProps = {\n    data: NonNullable<RelativeGrowthAdvantageData>;\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n    views: View[];\n};\n\nconst RelativeGrowthAdvantageTabs: FunctionComponent<RelativeGrowthAdvantageTabsProps> = ({\n    data,\n    yAxisScaleType,\n    setYAxisScaleType,\n    views,\n}) => {\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'line':\n                return {\n                    title: 'Line',\n                    content: (\n                        <RelativeGrowthAdvantageChart\n                            data={{\n                                ...data.estimatedProportions,\n                                observed: data.observedProportions,\n                                params: data.params,\n                            }}\n                            yAxisScaleType={yAxisScaleType}\n                        />\n                    ),\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n    const toolbar = () => (\n        <RelativeGrowthAdvantageToolbar yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n    );\n\n    return <Tabs tabs={tabs} toolbar={toolbar} />;\n};\n\ntype RelativeGrowthAdvantageToolbarProps = {\n    yAxisScaleType: ScaleType;\n    setYAxisScaleType: (scaleType: ScaleType) => void;\n};\n\nconst RelativeGrowthAdvantageToolbar: FunctionComponent<RelativeGrowthAdvantageToolbarProps> = ({\n    yAxisScaleType,\n    setYAxisScaleType,\n}) => {\n    return (\n        <div class='flex'>\n            <ScalingSelector yAxisScaleType={yAxisScaleType} setYAxisScaleType={setYAxisScaleType} />\n            <Info className='ml-1' content='Line chart' />\n        </div>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { RelativeGrowthAdvantage, type View } from '../../preact/relativeGrowthAdvantage/relative-growth-advantage';\nimport type { LapisFilter } from '../../types';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n@customElement('gs-relative-growth-advantage')\nexport class RelativeGrowthAdvantageComponent extends PreactLitAdapter {\n    @property({ type: Object })\n    numerator: LapisFilter = {};\n\n    @property({ type: Object })\n    denominator: LapisFilter = {};\n\n    @property({ type: Number })\n    generationTime: number = 7;\n\n    @property({ type: Array })\n    views: View[] = ['line'];\n\n    override render() {\n        return (\n            <RelativeGrowthAdvantage\n                numerator={this.numerator}\n                denominator={this.denominator}\n                generationTime={this.generationTime}\n                views={this.views}\n            />\n        );\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-relative-growth-advantage': RelativeGrowthAdvantageComponent;\n    }\n}\n","import { type FunctionComponent } from 'preact';\n\nimport { type AggregateData } from '../../query/queryAggregateData';\nimport { Table } from '../components/table';\nimport { formatProportion } from '../shared/table/formatProportion';\n\ntype AggregateTableProps = {\n    fields: string[];\n    data: AggregateData;\n};\n\nexport const AggregateTable: FunctionComponent<AggregateTableProps> = ({ data, fields }) => {\n    const headers = [\n        ...fields.map((field) => {\n            return {\n                name: field,\n                sort: true,\n            };\n        }),\n        {\n            name: 'count',\n            sort: true,\n        },\n        {\n            name: 'proportion',\n            sort: true,\n            formatter: (cell: number) => formatProportion(cell),\n        },\n    ];\n\n    return <Table data={data} columns={headers} pagination={true} />;\n};\n","import { FetchAggregatedOperator } from '../operator/FetchAggregatedOperator';\nimport { type LapisFilter } from '../types';\n\nexport type AggregateData = (Record<string, string | null | number | boolean> & {\n    count: number;\n    proportion: number;\n})[];\n\nexport async function queryAggregateData(variant: LapisFilter, fields: string[], lapis: string, signal?: AbortSignal) {\n    const fetchData = new FetchAggregatedOperator<Record<string, string | null | number>>(variant, fields);\n    const data = (await fetchData.evaluate(lapis, signal)).content;\n\n    const total = data.reduce((acc, row) => acc + row.count, 0);\n\n    return data.map(\n        (row) =>\n            ({\n                ...row,\n                proportion: row.count / total,\n            }) as Record<string, string | null | number | boolean> & {\n                count: number;\n                proportion: number;\n            },\n    );\n}\n","import { type FunctionComponent } from 'preact';\nimport { useContext } from 'preact/hooks';\n\nimport { AggregateTable } from './aggregate-table';\nimport { type AggregateData, queryAggregateData } from '../../query/queryAggregateData';\nimport { type LapisFilter } from '../../types';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { CsvDownloadButton } from '../components/csv-download-button';\nimport { ErrorDisplay } from '../components/error-display';\nimport Headline from '../components/headline';\nimport Info from '../components/info';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport Tabs from '../components/tabs';\nimport { useQuery } from '../useQuery';\n\nexport type View = 'table';\n\nexport interface AggregateProps {\n    filter: LapisFilter;\n    fields: string[];\n    views: View[];\n}\n\nexport const Aggregate: FunctionComponent<AggregateProps> = ({ fields, views, filter }) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const { data, error, isLoading } = useQuery(async () => {\n        return queryAggregateData(filter, fields, lapis);\n    }, [filter, fields, lapis]);\n\n    const headline = 'Aggregate';\n\n    if (isLoading) {\n        return (\n            <Headline heading={headline}>\n                <LoadingDisplay />\n            </Headline>\n        );\n    }\n\n    if (error !== null) {\n        return (\n            <Headline heading={headline}>\n                <ErrorDisplay error={error} />\n            </Headline>\n        );\n    }\n\n    if (data === null) {\n        return (\n            <Headline heading={headline}>\n                <NoDataDisplay />\n            </Headline>\n        );\n    }\n\n    return (\n        <Headline heading={headline}>\n            <AggregatedDataTabs data={data} views={views} fields={fields} />\n        </Headline>\n    );\n};\n\ntype AggregatedDataTabsProps = {\n    data: AggregateData;\n    fields: string[];\n    views: View[];\n};\n\nconst AggregatedDataTabs: FunctionComponent<AggregatedDataTabsProps> = ({ data, views, fields }) => {\n    const getTab = (view: View) => {\n        switch (view) {\n            case 'table':\n                return {\n                    title: 'Table',\n                    content: <AggregateTable data={data} fields={fields} />,\n                };\n        }\n    };\n\n    const tabs = views.map((view) => getTab(view));\n\n    return <Tabs tabs={tabs} toolbar={<Toolbar data={data} />} />;\n};\n\ntype ToolbarProps = {\n    data: AggregateData;\n};\n\nconst Toolbar: FunctionComponent<ToolbarProps> = ({ data }) => {\n    return (\n        <div class='flex flex-row'>\n            <CsvDownloadButton className='mx-1 btn btn-xs' getData={() => data} filename='aggregate.csv' />\n            <Info className='mx-1' content='Info for aggregate' />\n        </div>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { Aggregate, type View } from '../../preact/aggregatedData/aggregate';\nimport { type LapisFilter } from '../../types';\nimport { PreactLitAdapterWithGridJsStyles } from '../PreactLitAdapterWithGridJsStyles';\n\n/**\n * ## Tag\n *\n * `gs-aggregate-component`\n *\n * ## Context\n *\n * This component displays aggregated data, which can provide an overview of the underlying data.\n *\n * It expects a list of fields to aggregate by and a filter to apply to the data.\n */\n@customElement('gs-aggregate-component')\nexport class AggregateComponent extends PreactLitAdapterWithGridJsStyles {\n    /**\n     * The fields to aggregate by.\n     */\n    @property({ type: Array })\n    fields: string[] = [];\n\n    /**\n     * The views are used to display the aggregated data.\n     * In the table view, the data is presented in a table format where each field is a column,\n     * along with the aggregated value and its proportion.\n     * The proportion represents the ratio of the aggregated value to the total count of the data\n     * (considering the applied filter).\n     */\n    @property({ type: Array })\n    views: View[] = ['table'];\n\n    /**\n     * The filter to apply to the data.\n     */\n    @property({ type: Object })\n    filter: LapisFilter = {};\n\n    override render() {\n        return <Aggregate fields={this.fields} views={this.views} filter={this.filter} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-aggregate-component': AggregateComponent;\n    }\n}\n","export const toYYYYMMDD = (date?: Date) => {\n    if (!date) {\n        return undefined;\n    }\n\n    const options: Intl.DateTimeFormatOptions = { year: 'numeric', month: '2-digit', day: '2-digit' };\n    return date.toLocaleDateString('en-CA', options);\n};\n","import flatpickr from 'flatpickr';\nimport { type FunctionComponent } from 'preact';\nimport 'flatpickr/dist/flatpickr.min.css';\nimport { useEffect, useRef, useState } from 'preact/hooks';\n\nimport { toYYYYMMDD } from './dateConversion';\nimport { Select } from '../components/select';\nimport type { ScaleType } from '../shared/charts/getYAxisScale';\n\nexport type CustomSelectOption = { label: string; dateFrom: string; dateTo: string };\n\nexport interface DateRangeSelectorProps {\n    customSelectOptions: CustomSelectOption[];\n    earliestDate?: string;\n}\n\nexport const DateRangeSelector: FunctionComponent<DateRangeSelectorProps> = ({\n    customSelectOptions,\n    earliestDate = '1900-01-01',\n}) => {\n    const datePickerRef = useRef<HTMLInputElement>(null);\n    const endDatePickerRef = useRef<HTMLInputElement>(null);\n    const divRef = useRef<HTMLDivElement>(null);\n    const [dateFromPicker, setDateFromPicker] = useState<flatpickr.Instance | null>(null);\n    const [dateToPicker, setDateToPicker] = useState<flatpickr.Instance | null>(null);\n\n    const [selectedDateRange, setSelectedDateRange] = useState('last6Months');\n    const [selectedDates, setSelectedDates] = useState<{ dateFrom: Date; dateTo: Date }>({\n        dateFrom: getDatesForSelectorValue('last6Months', customSelectOptions, earliestDate).dateFrom,\n        dateTo: getDatesForSelectorValue('last6Months', customSelectOptions, earliestDate).dateTo,\n    });\n\n    useEffect(() => {\n        const commonConfig = {\n            allowInput: true,\n            dateFormat: 'Y-m-d',\n        };\n\n        if (datePickerRef.current) {\n            setDateFromPicker(\n                flatpickr(datePickerRef.current, {\n                    ...commonConfig,\n                    defaultDate: selectedDates.dateFrom,\n                }),\n            );\n        }\n\n        if (endDatePickerRef.current) {\n            setDateToPicker(\n                flatpickr(endDatePickerRef.current, {\n                    ...commonConfig,\n                    defaultDate: selectedDates.dateTo,\n                }),\n            );\n        }\n\n        return () => {\n            dateFromPicker?.destroy();\n            dateToPicker?.destroy();\n        };\n        // eslint-disable-next-line react-hooks/exhaustive-deps\n    }, [datePickerRef, endDatePickerRef]);\n\n    const selectableOptions = () => {\n        const presetOptions = [\n            { label: 'Custom', value: 'custom' },\n            { label: 'All times', value: 'allTimes' },\n            { label: 'Last 2 weeks', value: 'last2Weeks' },\n            { label: 'Last month', value: 'lastMonth' },\n            { label: 'Last 2 weeks', value: 'last2Weeks' },\n            { label: 'Last month', value: 'lastMonth' },\n            { label: 'Last 2 months', value: 'last2Months' },\n            { label: 'Last 3 months', value: 'last3Months' },\n            { label: 'Last 6 months', value: 'last6Months' },\n        ];\n\n        const customOptions = customSelectOptions.map((customSelectOption) => {\n            return { label: customSelectOption.label, value: customLabelToOptionValue(customSelectOption.label) };\n        });\n\n        return [...presetOptions, ...customOptions];\n    };\n\n    const onSelectChange = (value: string) => {\n        setSelectedDateRange(value);\n\n        const dateRange = getDatesForSelectorValue(value, customSelectOptions, earliestDate);\n\n        dateToPicker?.set('minDate', dateRange.dateFrom);\n        dateFromPicker?.set('maxDate', dateRange.dateTo);\n\n        dateFromPicker?.setDate(dateRange.dateFrom);\n        dateToPicker?.setDate(dateRange.dateTo);\n\n        setSelectedDates({\n            dateFrom: dateRange.dateFrom,\n            dateTo: dateRange.dateTo,\n        });\n\n        submit();\n    };\n\n    const onChangeDateFrom = () => {\n        if (selectedDates.dateFrom.toDateString() === dateFromPicker?.selectedDates[0].toDateString()) {\n            return;\n        }\n\n        selectedDates.dateFrom = dateFromPicker?.selectedDates[0] || new Date();\n        dateToPicker?.set('minDate', dateFromPicker?.selectedDates[0]);\n        setSelectedDateRange('custom');\n\n        submit();\n    };\n\n    const onChangeDateTo = () => {\n        if (selectedDates.dateTo.toDateString() === dateToPicker?.selectedDates[0].toDateString()) {\n            return;\n        }\n\n        selectedDates.dateTo = dateToPicker?.selectedDates[0] || new Date();\n        dateFromPicker?.set('maxDate', dateToPicker?.selectedDates[0]);\n        setSelectedDateRange('custom');\n\n        submit();\n    };\n\n    const submit = () => {\n        const dateFrom = toYYYYMMDD(dateFromPicker?.selectedDates[0]);\n        const dateTo = toYYYYMMDD(dateToPicker?.selectedDates[0]);\n\n        const detail = {\n            ...(dateFrom !== undefined && { dateFrom }),\n            ...(dateTo !== undefined && { dateTo }),\n        };\n\n        divRef.current?.dispatchEvent(\n            new CustomEvent('gs-date-range-changed', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    return (\n        <div class='join' ref={divRef}>\n            <Select\n                items={selectableOptions()}\n                selected={selectedDateRange}\n                selectStyle='select-bordered rounded-none join-item'\n                onChange={(event: Event) => {\n                    event.preventDefault();\n                    const select = event.target as HTMLSelectElement;\n                    const value = select.value as ScaleType;\n                    onSelectChange(value);\n                }}\n            />\n            <input\n                class='input input-bordered rounded-none join-item'\n                type='text'\n                placeholder='Date from'\n                ref={datePickerRef}\n                onChange={onChangeDateFrom}\n                onBlur={onChangeDateFrom}\n            />\n            <input\n                class='input input-bordered rounded-none join-item'\n                type='text'\n                placeholder='Date to'\n                ref={endDatePickerRef}\n                onChange={onChangeDateTo}\n                onBlur={onChangeDateFrom}\n            />\n        </div>\n    );\n};\n\nconst customLabelToOptionValue = (customLabel: string) => {\n    return `${customLabel}customLabel`;\n};\n\nconst getDatesForSelectorValue = (\n    selectorValue: string,\n    customSelectOptions: CustomSelectOption[],\n    earliestDate: string,\n) => {\n    const today = new Date();\n\n    const customSelectOption = customSelectOptions.find(\n        (option) => customLabelToOptionValue(option.label) === selectorValue,\n    );\n    if (customSelectOption) {\n        return { dateFrom: new Date(customSelectOption.dateFrom), dateTo: new Date(customSelectOption.dateTo) };\n    }\n\n    switch (selectorValue) {\n        case 'last2Weeks': {\n            const twoWeeksAgo = new Date(today);\n            twoWeeksAgo.setDate(today.getDate() - 14);\n            return { dateFrom: twoWeeksAgo, dateTo: today };\n        }\n        case 'lastMonth': {\n            const lastMonth = new Date(today);\n            lastMonth.setMonth(today.getMonth() - 1);\n            return { dateFrom: lastMonth, dateTo: today };\n        }\n        case 'last2Months': {\n            const twoMonthsAgo = new Date(today);\n            twoMonthsAgo.setMonth(today.getMonth() - 2);\n            return { dateFrom: twoMonthsAgo, dateTo: today };\n        }\n        case 'last3Months': {\n            const threeMonthsAgo = new Date(today);\n            threeMonthsAgo.setMonth(today.getMonth() - 3);\n            return { dateFrom: threeMonthsAgo, dateTo: today };\n        }\n        case 'last6Months': {\n            const sixMonthsAgo = new Date(today);\n            sixMonthsAgo.setMonth(today.getMonth() - 6);\n            return { dateFrom: sixMonthsAgo, dateTo: today };\n        }\n        case 'allTimes': {\n            return { dateFrom: new Date(earliestDate), dateTo: today };\n        }\n        default:\n            return { dateFrom: today, dateTo: today };\n    }\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { type CustomSelectOption, DateRangeSelector } from '../../preact/dateRangeSelector/date-range-selector';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * @fires {CustomEvent<{ dateFrom: string; dateTo: string; }>} gs-date-range-changed - When the date range has changed\n */\n@customElement('gs-date-range-selector')\nexport class DateRangeSelectorComponent extends PreactLitAdapter {\n    @property({ type: Array })\n    customSelectOptions: CustomSelectOption[] = [];\n\n    @property({ type: String })\n    earliestDate: string | undefined = '1900-01-01';\n\n    override render() {\n        return <DateRangeSelector customSelectOptions={this.customSelectOptions} earliestDate={this.earliestDate} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-date-range-selector': DateRangeSelectorComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-date-range-changed': CustomEvent<{\n            dateFrom: string;\n            dateTo: string;\n        }>;\n    }\n}\n","import { FetchAggregatedOperator } from '../../operator/FetchAggregatedOperator';\n\nexport async function fetchAutocompletionList(fields: string[], lapis: string, signal?: AbortSignal) {\n    const toAncestorInHierarchyOverwriteValues = Array(fields.length - 1)\n        .fill(0)\n        .map((_, i) => i + 1)\n        .map((i) => fields.slice(i).reduce((acc, field) => ({ ...acc, [field]: null }), {}));\n\n    const fetchAggregatedOperator = new FetchAggregatedOperator<Record<string, string | null>>({}, fields);\n\n    const data = (await fetchAggregatedOperator.evaluate(lapis, signal)).content;\n    const locationValues = data\n        .map((entry) => fields.reduce((acc, field) => ({ ...acc, [field]: entry[field] }), {}))\n        .reduce<Set<string>>((setOfAllHierarchies, entry) => {\n            setOfAllHierarchies.add(JSON.stringify(entry));\n            toAncestorInHierarchyOverwriteValues.forEach((overwriteValues) => {\n                setOfAllHierarchies.add(JSON.stringify({ ...entry, ...overwriteValues }));\n            });\n            return setOfAllHierarchies;\n        }, new Set());\n\n    return [...locationValues].map((json) => JSON.parse(json)).sort(compareLocationEntries(fields));\n}\n\nfunction compareLocationEntries(fields: string[]) {\n    return (a: Record<string, string | null>, b: Record<string, string | null>) => {\n        for (const field of fields) {\n            const valueA = a[field];\n            const valueB = b[field];\n            if (valueA === valueB) {\n                continue;\n            }\n            if (valueA === null) {\n                return -1;\n            }\n            if (valueB === null) {\n                return 1;\n            }\n            return valueA < valueB ? -1 : 1;\n        }\n        return 0;\n    };\n}\n","import { useContext, useRef, useState } from 'preact/hooks';\n\nimport { fetchAutocompletionList } from './fetchAutocompletionList';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { useQuery } from '../useQuery';\n\nexport type LocationFilterProps = {\n    value?: string;\n    fields: string[];\n};\n\nexport const LocationFilter = ({ value: initialValue, fields }: LocationFilterProps) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const [value, setValue] = useState(initialValue ?? '');\n    const [unknownLocation, setUnknownLocation] = useState(false);\n\n    const formRef = useRef<HTMLFormElement>(null);\n\n    const { data, error, isLoading } = useQuery(() => fetchAutocompletionList(fields, lapis), [fields, lapis]);\n\n    if (isLoading)\n        return (\n            <form class='flex'>\n                <input type='text' class='input input-bordered grow' value={value} disabled />\n                <button class='btn ml-1' disabled type='submit'>\n                    Loading...\n                </button>\n            </form>\n        );\n\n    if (error) {\n        return (\n            <p>\n                Error: {error.name} {error.message} {error.stack}\n            </p>\n        );\n    }\n\n    const onInput = (event: InputEvent) => {\n        if (event.target instanceof HTMLInputElement) {\n            const inputValue = event.target.value;\n            setValue(inputValue);\n            if (unknownLocation) {\n                const eventDetail = parseLocation(inputValue, fields);\n                if (hasMatchingEntry(data, eventDetail)) {\n                    setUnknownLocation(false);\n                }\n            }\n        }\n    };\n\n    const submit = (event: SubmitEvent) => {\n        event.preventDefault();\n        const eventDetail = parseLocation(value, fields);\n\n        if (hasMatchingEntry(data, eventDetail)) {\n            setUnknownLocation(false);\n\n            formRef.current?.dispatchEvent(\n                new CustomEvent('gs-location-changed', {\n                    detail: eventDetail,\n                    bubbles: true,\n                    composed: true,\n                }),\n            );\n        } else {\n            setUnknownLocation(true);\n        }\n    };\n\n    return (\n        <form class='flex' onSubmit={submit} ref={formRef}>\n            <input\n                type='text'\n                class={`input input-bordered grow ${unknownLocation ? 'border-2 border-error' : ''}`}\n                value={value}\n                onInput={onInput}\n                list='countries'\n            />\n            <datalist id='countries'>\n                {data?.map((v) => {\n                    const value = fields\n                        .map((field) => v[field])\n                        .filter((value) => value !== null)\n                        .join(' / ');\n                    return <option key={value} value={value} />;\n                })}\n            </datalist>\n            <button class='btn btn-primary ml-1' type='submit'>\n                Submit\n            </button>\n        </form>\n    );\n};\n\nconst parseLocation = (location: string, fields: string[]) => {\n    const fieldValues = location.split('/').map((part) => part.trim());\n    return fieldValues.reduce((acc, fieldValue, i) => ({ ...acc, [fields[i]]: fieldValue }), {});\n};\n\nconst hasMatchingEntry = (data: Record<string, string>[] | null, eventDetail: Record<string, string>) => {\n    if (data === null) {\n        return false;\n    }\n\n    const matchingEntries = Object.entries(eventDetail)\n        .filter(([, value]) => value !== undefined)\n        .reduce((filteredData, [key, value]) => filteredData.filter((it) => it[key] === value), data);\n\n    return matchingEntries.length > 0;\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { LocationFilter } from '../../preact/locationFilter/location-filter';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * ## Tag\n *\n * `gs-location-filter`\n *\n * ## Context\n *\n * This component provides an input field to specify filters for locations.\n *\n * It expects a list of fields that form a strict hierarchical order, such as continent, country, and city.\n * The component retrieves a list of all possible values for these fields from the Lapis instance.\n * This list is then utilized to display autocomplete suggestions and to validate the input.\n *\n * Given `fields` are `['field1', 'field2', ..., 'fieldN']`,\n * then valid values for the location filter must be in the form `valueForField1 / valueForField2 / ... / valueForFieldK`,\n * where `1 <= K <= N`.\n * Values for the fields `i > K` are considered `undefined`.\n *\n * @fires {CustomEvent<Record<string, string>>} gs-location-changed\n * Fired when the field is submitted with a valid location value.\n * The `details` of this event contain an object with all `fields` as keys\n * and the corresponding values as values, if they are not `undefined`.\n * Example:\n * ```\n * {\n *   continent: \"Asia\",\n *   country: \"China\",\n *   city: \"Beijing\"\n * }\n * ```\n */\n@customElement('gs-location-filter')\nexport class LocationFilterComponent extends PreactLitAdapter {\n    /**\n     * The initial value to use for this location filter.\n     * Must be of the form `valueForField1 / valueForField2 / ... / valueForFieldN`.\n     */\n    @property()\n    value = '';\n\n    /**\n     * The fields to display in the location filter, in hierarchical order.\n     * The top-level field should be the first entry in the array.\n     * This component assumes that the values for each field form a strict hierarchy\n     * (e.g., `fields = ['continent', 'country', 'city']`).\n     */\n    @property({ type: Array })\n    fields: string[] = [];\n\n    override render() {\n        return <LocationFilter value={this.value} fields={this.fields} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-location-filter': LocationFilterComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-location-changed': CustomEvent<Record<string, string>>;\n    }\n}\n","import { FetchAggregatedOperator } from '../../operator/FetchAggregatedOperator';\n\nexport async function fetchAutocompleteList(lapis: string, field: string, signal?: AbortSignal) {\n    const fetchAggregatedOperator = new FetchAggregatedOperator<Record<string, string>>({}, [field]);\n\n    const data = (await fetchAggregatedOperator.evaluate(lapis, signal)).content;\n\n    return data.map((item) => item[field]);\n}\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useRef } from 'preact/hooks';\n\nimport { fetchAutocompleteList } from './fetchAutocompleteList';\nimport { LapisUrlContext } from '../LapisUrlContext';\nimport { ErrorDisplay } from '../components/error-display';\nimport { LoadingDisplay } from '../components/loading-display';\nimport { NoDataDisplay } from '../components/no-data-display';\nimport { useQuery } from '../useQuery';\n\nexport interface TextInputProps {\n    lapisField: string;\n    placeholderText?: string;\n}\n\nexport const TextInput: FunctionComponent<TextInputProps> = ({ lapisField, placeholderText }) => {\n    const lapis = useContext(LapisUrlContext);\n\n    const inputRef = useRef<HTMLInputElement>(null);\n\n    const { data, error, isLoading } = useQuery(() => fetchAutocompleteList(lapis, lapisField), [lapisField, lapis]);\n\n    if (isLoading) {\n        return <LoadingDisplay />;\n    }\n\n    if (error !== null) {\n        return <ErrorDisplay error={error} />;\n    }\n\n    if (data === null) {\n        return <NoDataDisplay />;\n    }\n\n    const onInput = () => {\n        const value = inputRef.current?.value;\n\n        if (isValidValue(value)) {\n            inputRef.current?.dispatchEvent(\n                new CustomEvent('gs-text-input-changed', {\n                    detail: { [lapisField]: value },\n                    bubbles: true,\n                    composed: true,\n                }),\n            );\n        }\n    };\n\n    const isValidValue = (value: string | undefined) => {\n        if (value === undefined) {\n            return false;\n        }\n        return data.includes(value);\n    };\n\n    return (\n        <>\n            <input\n                type='text'\n                class='input input-bordered'\n                placeholder={placeholderText !== undefined ? placeholderText : lapisField}\n                onInput={onInput}\n                ref={inputRef}\n                list={lapisField}\n            />\n            <datalist id={lapisField}>\n                {data.map((item) => (\n                    <option value={item} key={item} />\n                ))}\n            </datalist>\n        </>\n    );\n};\n","import { customElement, property } from 'lit/decorators.js';\n\nimport { TextInput } from '../../preact/textInput/text-input';\nimport { PreactLitAdapter } from '../PreactLitAdapter';\n\n/**\n * @fires {CustomEvent<Record<string, string>>} gs-text-input-changed - When the text input has changed\n */\n@customElement('gs-text-input')\nexport class TextInputComponent extends PreactLitAdapter {\n    @property()\n    lapisField = '';\n\n    @property()\n    placeholderText = '';\n\n    override render() {\n        return <TextInput lapisField={this.lapisField} placeholderText={this.placeholderText} />;\n    }\n}\n\ndeclare global {\n    interface HTMLElementTagNameMap {\n        'gs-text-input': TextInputComponent;\n    }\n\n    interface HTMLElementEventMap {\n        'gs-text-input-changed': CustomEvent<Record<string, string>>;\n    }\n}\n","import type { ReferenceGenome } from '../../lapisApi/ReferenceGenome';\nimport type { SequenceType } from '../../types';\n\nexport const sequenceTypeFromSegment = (\n    possibleSegment: string | undefined,\n    referenceGenome: ReferenceGenome,\n): SequenceType | undefined => {\n    if (possibleSegment === undefined) {\n        return referenceGenome.nucleotideSequences.length === 1 ? 'nucleotide' : undefined;\n    }\n\n    if (referenceGenome.nucleotideSequences.some((sequence) => sequence.name === possibleSegment)) {\n        return 'nucleotide';\n    }\n\n    if (referenceGenome.genes.some((gene) => gene.name === possibleSegment)) {\n        return 'amino acid';\n    }\n    return undefined;\n};\n","import { type SelectedFilters } from './mutation-filter';\nimport { sequenceTypeFromSegment } from './sequenceTypeFromSegment';\nimport type { ReferenceGenome } from '../../lapisApi/ReferenceGenome';\nimport { Deletion, Insertion, Substitution } from '../../utils/mutations';\n\ntype ParsedMutationFilter = {\n    [MutationType in keyof SelectedFilters]: { type: MutationType; value: SelectedFilters[MutationType][number] };\n}[keyof SelectedFilters];\n\nexport const parseAndValidateMutation = (\n    value: string,\n    referenceGenome: ReferenceGenome,\n): ParsedMutationFilter | null => {\n    const possibleInsertion = Insertion.parse(value);\n    if (possibleInsertion !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleInsertion.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideInsertions', value: possibleInsertion };\n            case 'amino acid':\n                return { type: 'aminoAcidInsertions', value: possibleInsertion };\n            case undefined:\n                return null;\n        }\n    }\n\n    const possibleDeletion = Deletion.parse(value);\n    if (possibleDeletion !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleDeletion.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideMutations', value: possibleDeletion };\n            case 'amino acid':\n                return { type: 'aminoAcidMutations', value: possibleDeletion };\n            case undefined:\n                return null;\n        }\n    }\n\n    const possibleSubstitution = Substitution.parse(value);\n    if (possibleSubstitution !== null) {\n        const sequenceType = sequenceTypeFromSegment(possibleSubstitution.segment, referenceGenome);\n        switch (sequenceType) {\n            case 'nucleotide':\n                return { type: 'nucleotideMutations', value: possibleSubstitution };\n            case 'amino acid':\n                return { type: 'aminoAcidMutations', value: possibleSubstitution };\n            case undefined:\n                return null;\n        }\n    }\n\n    return null;\n};\n","import type { FunctionComponent } from 'preact';\n\nexport const DeleteIcon: FunctionComponent = () => {\n    return (\n        <svg\n            fill='currentColor'\n            stroke-width='0'\n            xmlns='http://www.w3.org/2000/svg'\n            viewBox='0 0 16 16'\n            style='overflow: visible; color: currentcolor;'\n            height='1em'\n            width='1em'\n        >\n            <path d='M4.646 4.646a.5.5 0 0 1 .708 0L8 7.293l2.646-2.647a.5.5 0 0 1 .708.708L8.707 8l2.647 2.646a.5.5 0 0 1-.708.708L8 8.707l-2.646 2.647a.5.5 0 0 1-.708-.708L7.293 8 4.646 5.354a.5.5 0 0 1 0-.708z' />\n        </svg>\n    );\n};\n","import { type FunctionComponent } from 'preact';\nimport { useContext, useRef, useState } from 'preact/hooks';\n\nimport { parseAndValidateMutation } from './parseAndValidateMutation';\nimport { type Deletion, type Insertion, type Mutation, type Substitution } from '../../utils/mutations';\nimport { ReferenceGenomeContext } from '../ReferenceGenomeContext';\nimport { singleGraphColorRGBByName } from '../shared/charts/colors';\nimport { DeleteIcon } from '../shared/icons/DeleteIcon';\n\nexport type MutationFilterProps = {};\n\nexport type SelectedFilters = {\n    nucleotideMutations: (Substitution | Deletion)[];\n    aminoAcidMutations: (Substitution | Deletion)[];\n    nucleotideInsertions: Insertion[];\n    aminoAcidInsertions: Insertion[];\n};\n\nexport type SelectedMutationFilterStrings = {\n    [Key in keyof SelectedFilters]: string[];\n};\n\nexport const MutationFilter: FunctionComponent<MutationFilterProps> = () => {\n    const referenceGenome = useContext(ReferenceGenomeContext);\n    const [selectedFilters, setSelectedFilters] = useState<SelectedFilters>({\n        nucleotideMutations: [],\n        aminoAcidMutations: [],\n        nucleotideInsertions: [],\n        aminoAcidInsertions: [],\n    });\n    const [inputValue, setInputValue] = useState('');\n    const [isError, setIsError] = useState(false);\n    const formRef = useRef<HTMLFormElement>(null);\n\n    const handleSubmit = (event: Event) => {\n        event.preventDefault();\n\n        const parsedMutation = parseAndValidateMutation(inputValue, referenceGenome);\n\n        if (parsedMutation === null) {\n            setIsError(true);\n            return;\n        }\n\n        const newSelectedValues = {\n            ...selectedFilters,\n            [parsedMutation.type]: [...selectedFilters[parsedMutation.type], parsedMutation.value],\n        };\n\n        setSelectedFilters(newSelectedValues);\n        fireChangeEvent(newSelectedValues);\n        setInputValue('');\n    };\n\n    const fireChangeEvent = (selectedFilters: SelectedFilters) => {\n        const detail = mapToMutationFilterStrings(selectedFilters);\n\n        formRef.current?.dispatchEvent(\n            new CustomEvent<SelectedMutationFilterStrings>('gs-mutation-filter-changed', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    const handleOnBlur = () => {\n        const detail = mapToMutationFilterStrings(selectedFilters);\n\n        formRef.current?.dispatchEvent(\n            new CustomEvent<SelectedMutationFilterStrings>('gs-mutation-filter-on-blur', {\n                detail,\n                bubbles: true,\n                composed: true,\n            }),\n        );\n    };\n\n    const handleInputChange = (event: Event) => {\n        setInputValue((event.target as HTMLInputElement).value);\n        setIsError(false);\n    };\n\n    return (\n        <div class={`rounded-lg border border-gray-300 bg-white p-2`}>\n            <SelectedMutationDisplay\n                selectedFilters={selectedFilters}\n                setSelectedFilters={setSelectedFilters}\n                fireChangeEvent={fireChangeEvent}\n            />\n\n            <form className='mt-2 w-full' onSubmit={handleSubmit} ref={formRef}>\n                <label className={`input flex items-center gap-2 ${isError ? 'input-error' : 'input-bordered'}`}>\n                    <input\n                        className='grow min-w-0'\n                        type='text'\n                        value={inputValue}\n                        onInput={handleInputChange}\n                        placeholder={'Enter a mutation'}\n                        onBlur={handleOnBlur}\n                    />\n                    <button className='btn btn-sm'>+</button>\n                </label>\n            </form>\n        </div>\n    );\n};\n\nconst SelectedMutationDisplay: FunctionComponent<{\n    selectedFilters: SelectedFilters;\n    setSelectedFilters: (selectedFilters: SelectedFilters) => void;\n    fireChangeEvent: (selectedFilters: SelectedFilters) => void;\n}> = ({ selectedFilters, setSelectedFilters, fireChangeEvent }) => {\n    const onSelectedRemoved = <MutationType extends keyof SelectedFilters>(\n        mutation: SelectedFilters[MutationType][number],\n        key: MutationType,\n    ) => {\n        const newSelectedValues = {\n            ...selectedFilters,\n            [key]: selectedFilters[key].filter((i) => !mutation.equals(i)),\n        };\n\n        setSelectedFilters(newSelectedValues);\n\n        fireChangeEvent(newSelectedValues);\n    };\n\n    return (\n        <ul class='flex flex-wrap'>\n            {selectedFilters.nucleotideMutations.map((mutation) => (\n                <li key={mutation.toString()}>\n                    <SelectedNucleotideMutation\n                        mutation={mutation}\n                        onDelete={(mutation: Substitution | Deletion) =>\n                            onSelectedRemoved(mutation, 'nucleotideMutations')\n                        }\n                    />\n                </li>\n            ))}\n            {selectedFilters.aminoAcidMutations.map((mutation) => (\n                <li key={mutation.toString()}>\n                    <SelectedAminoAcidMutation\n                        mutation={mutation}\n                        onDelete={(mutation: Substitution | Deletion) =>\n                            onSelectedRemoved(mutation, 'aminoAcidMutations')\n                        }\n                    />\n                </li>\n            ))}\n            {selectedFilters.nucleotideInsertions.map((insertion) => (\n                <li key={insertion.toString()}>\n                    <SelectedNucleotideInsertion\n                        insertion={insertion}\n                        onDelete={(insertion) => onSelectedRemoved(insertion, 'nucleotideInsertions')}\n                    />\n                </li>\n            ))}\n            {selectedFilters.aminoAcidInsertions.map((insertion) => (\n                <li key={insertion.toString()}>\n                    <SelectedAminoAcidInsertion\n                        insertion={insertion}\n                        onDelete={(insertion: Insertion) => onSelectedRemoved(insertion, 'aminoAcidInsertions')}\n                    />\n                </li>\n            ))}\n        </ul>\n    );\n};\n\nconst SelectedAminoAcidInsertion: FunctionComponent<{\n    insertion: Insertion;\n    onDelete: (insertion: Insertion) => void;\n}> = ({ insertion, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('teal', 0.3);\n    const textColor = singleGraphColorRGBByName('teal', 1);\n    return (\n        <SelectedFilter\n            mutation={insertion}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedAminoAcidMutation: FunctionComponent<{\n    mutation: Substitution | Deletion;\n    onDelete: (mutation: Substitution | Deletion) => void;\n}> = ({ mutation, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('rose', 0.3);\n    const textColor = singleGraphColorRGBByName('rose', 1);\n    return (\n        <SelectedFilter\n            mutation={mutation}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedNucleotideMutation: FunctionComponent<{\n    mutation: Substitution | Deletion;\n    onDelete: (insertion: Substitution | Deletion) => void;\n}> = ({ mutation, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('indigo', 0.3);\n    const textColor = singleGraphColorRGBByName('indigo', 1);\n    return (\n        <SelectedFilter\n            mutation={mutation}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\nconst SelectedNucleotideInsertion: FunctionComponent<{\n    insertion: Insertion;\n    onDelete: (insertion: Insertion) => void;\n}> = ({ insertion, onDelete }) => {\n    const backgroundColor = singleGraphColorRGBByName('green', 0.3);\n    const textColor = singleGraphColorRGBByName('green', 1);\n\n    return (\n        <SelectedFilter\n            mutation={insertion}\n            onDelete={onDelete}\n            backgroundColor={backgroundColor}\n            textColor={textColor}\n        />\n    );\n};\n\ntype SelectedFilterProps<MutationType extends Mutation> = {\n    mutation: MutationType;\n    onDelete: (mutation: MutationType) => void;\n    backgroundColor: string;\n    textColor: string;\n};\n\nconst SelectedFilter = <MutationType extends Mutation>({\n    mutation,\n    onDelete,\n    backgroundColor,\n    textColor,\n}: SelectedFilterProps<MutationType>) => {\n    return (\n        <div\n            class='flex items-center flex-nowrap gap-1 rounded me-1 px-2.5 py-0.5 font-medium text-xs mb-1'\n            style={{ backgroundColor, color: textColor }}\n        >\n            <div>{mutation.toString()}</div>\n            <button onClick={() => onDelete(mutation)}>\n                <DeleteIcon />\n            </button>\n        </div>\n    );\n};\n\nfunction mapToMutationFilterStrings(selectedFilters: SelectedFilters) {\n 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