@genome-spy/core 0.77.0 → 0.79.0

package/dist/bundle/esm-CscjKVDc.js

@@ -1,1426 +0,0 @@
-import { n as e, r as t } from "./esm-C49STiCR.js";
-import { t as n } from "./esm-CuVa5T98.js";
-import { r, t as i } from "./browser-KWU9rWZT.js";
-//#region ../../node_modules/@gmod/bam/esm/chunk.js
-var a = class {
-	constructor(e, t, n, r) {
-		this.minv = e, this.maxv = t, this.bin = n, this._fetchedSize = r;
-	}
-	toUniqueString() {
-		return `${this.minv.toString()}..${this.maxv.toString()} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`;
-	}
-	toString() {
-		return this.toUniqueString();
-	}
-	compareTo(e) {
-		return this.minv.compareTo(e.minv) || this.maxv.compareTo(e.maxv) || this.bin - e.bin;
-	}
-	fetchedSize() {
-		return this._fetchedSize === void 0 ? this.maxv.blockPosition + 65536 - this.minv.blockPosition : this._fetchedSize;
-	}
-}, o = 65536, s = o * o;
-function c(e, t = 0) {
-	let n = e[t] | e[t + 1] << 8 | e[t + 2] << 16 | e[t + 3] << 24;
-	return ((e[t + 4] | e[t + 5] << 8 | e[t + 6] << 16 | e[t + 7] << 24) >>> 0) * s + (n >>> 0);
-}
-//#endregion
-//#region ../../node_modules/@gmod/bam/esm/util.js
-function l(e = {}) {
-	return "aborted" in e ? { signal: e } : e;
-}
-function u(e, t) {
-	let n = e.length;
-	if (n === 0) return e;
-	let r;
-	if (t) {
-		let i = t.blockPosition, a = t.dataPosition;
-		r = [];
-		for (let t = 0; t < n; t++) {
-			let n = e[t], o = n.maxv;
-			(o.blockPosition - i || o.dataPosition - a) > 0 && r.push(n);
-		}
-		if (r.length === 0) return r;
-	} else r = e;
-	r.sort((e, t) => {
-		let n = e.minv.blockPosition - t.minv.blockPosition;
-		return n === 0 ? e.minv.dataPosition - t.minv.dataPosition : n;
-	});
-	let i = [], a = r[0];
-	i.push(a);
-	let o = a.minv.blockPosition, s = a.maxv.blockPosition;
-	for (let e = 1; e < r.length; e++) {
-		let t = r[e], n = t.minv.blockPosition, c = t.maxv.blockPosition;
-		if (n - s < 65e3 && c - o < 5e6) {
-			let e = t.maxv, n = a.maxv;
-			(c - s || e.dataPosition - n.dataPosition) > 0 && (a.maxv = e, s = c);
-		} else i.push(t), a = t, o = n, s = c;
-	}
-	return i;
-}
-function d(e, t) {
-	return { lineCount: c(e, t) };
-}
-function f(e, t) {
-	return e ? e.compareTo(t) > 0 ? t : e : t;
-}
-function p(e, t = (e) => e) {
-	let n = 0, r = 0, i = [], a = {};
-	for (let o = 0; o < e.length; o += 1) if (!e[o]) {
-		if (r < o) {
-			let s = "";
-			for (let t = r; t < o; t++) s += String.fromCharCode(e[t]);
-			s = t(s), i[n] = s, a[s] = n;
-		}
-		r = o + 1, n += 1;
-	}
-	return {
-		refNameToId: a,
-		refIdToName: i
-	};
-}
-function m(e) {
-	let t = 0;
-	for (let n of e) t += n.length;
-	let n = new Uint8Array(t), r = 0;
-	for (let t of e) n.set(t, r), r += t.length;
-	return n;
-}
-function h(e, t, n) {
-	return !!((e & t) !== t || e & n);
-}
-function g(e, t) {
-	return t === "*" ? e === void 0 : `${e}` != `${t}`;
-}
-function _(e) {
-	if (!e) return "";
-	let { flagInclude: t = 0, flagExclude: n = 0, tagFilter: r } = e;
-	return `:f${t}x${n}${r ? `:${r.tag}=${r.value ?? "*"}` : ""}`;
-}
-//#endregion
-//#region ../../node_modules/@gmod/bam/esm/indexFile.js
-var v = class {
-	constructor({ filehandle: e, renameRefSeq: t = (e) => e }) {
-		this.filehandle = e, this.renameRefSeq = t;
-	}
-	async estimatedBytesForRegions(e, t) {
-		let n = u((await Promise.all(e.map((e) => this.blocksForRange(e.refId, e.start, e.end, t)))).flat()), r = 0;
-		for (let e of n) r += e.fetchedSize();
-		return r;
-	}
-}, y = class {
-	constructor(e, t) {
-		this.blockPosition = e, this.dataPosition = t;
-	}
-	toString() {
-		return `${this.blockPosition}:${this.dataPosition}`;
-	}
-	compareTo(e) {
-		return this.blockPosition - e.blockPosition || this.dataPosition - e.dataPosition;
-	}
-};
-function b(e, t = 0, n = !1) {
-	if (n) throw Error("big-endian virtual file offsets not implemented");
-	return new y(e[t + 7] * 1099511627776 + e[t + 6] * 4294967296 + e[t + 5] * 16777216 + e[t + 4] * 65536 + e[t + 3] * 256 + e[t + 2], e[t + 1] << 8 | e[t]);
-}
-//#endregion
-//#region ../../node_modules/@gmod/bam/esm/bai.js
-var x = 21578050;
-function S(e, t) {
-	return e - e % t;
-}
-function C(e, t) {
-	return e - e % t + t;
-}
-function w(e, t) {
-	return --t, [
-		[0, 0],
-		[1 + (e >> 26), 1 + (t >> 26)],
-		[9 + (e >> 23), 9 + (t >> 23)],
-		[73 + (e >> 20), 73 + (t >> 20)],
-		[585 + (e >> 17), 585 + (t >> 17)],
-		[4681 + (e >> 14), 4681 + (t >> 14)]
-	];
-}
-var T = class extends v {
-	async lineCount(e, t) {
-		return (await this.parse(t)).indices(e)?.stats?.lineCount || 0;
-	}
-	async _parse(e) {
-		let t = await this.filehandle.readFile(), r = new DataView(t.buffer);
-		if (r.getUint32(0, !0) !== x) throw Error("Not a BAI file");
-		let i = r.getInt32(4, !0), o = ((1 << 18) - 1) / 7, s = 8, c, l = [];
-		for (let e = 0; e < i; e++) {
-			l.push(s);
-			let e = r.getInt32(s, !0);
-			s += 4;
-			for (let t = 0; t < e; t += 1) {
-				let e = r.getUint32(s, !0);
-				if (s += 4, e === o + 1) s += 4, s += 32;
-				else if (e > o + 1) throw Error("bai index contains too many bins, please use CSI");
-				else {
-					let e = r.getInt32(s, !0);
-					s += 4;
-					for (let t = 0; t < e; t++) s += 8, s += 8;
-				}
-			}
-			let n = r.getInt32(s, !0);
-			s += 4;
-			let i = Array(n);
-			for (let e = 0; e < n; e++) {
-				let n = b(t, s);
-				s += 8, c = f(c, n), i[e] = n;
-			}
-		}
-		let u = new n({ maxSize: 5 });
-		function p(e) {
-			let n = l[e];
-			if (n === void 0) return;
-			let i = r.getInt32(n, !0), s;
-			n += 4;
-			let u = {};
-			for (let e = 0; e < i; e += 1) {
-				let e = r.getUint32(n, !0);
-				if (n += 4, e === o + 1) n += 4, s = d(t, n + 16), n += 32;
-				else if (e > o + 1) throw Error("bai index contains too many bins, please use CSI");
-				else {
-					let i = r.getInt32(n, !0);
-					n += 4;
-					let o = Array(i);
-					for (let r = 0; r < i; r++) {
-						let i = b(t, n);
-						n += 8;
-						let s = b(t, n);
-						n += 8, c = f(c, i), o[r] = new a(i, s, e);
-					}
-					u[e] = o;
-				}
-			}
-			let p = r.getInt32(n, !0);
-			n += 4;
-			let m = Array(p);
-			for (let e = 0; e < p; e++) {
-				let r = b(t, n);
-				n += 8, c = f(c, r), m[e] = r;
-			}
-			return {
-				binIndex: u,
-				linearIndex: m,
-				stats: s
-			};
-		}
-		return {
-			bai: !0,
-			firstDataLine: c,
-			maxBlockSize: 65536,
-			indices: (e) => {
-				if (!u.has(e)) {
-					let t = p(e);
-					return t && u.set(e, t), t;
-				}
-				return u.get(e);
-			},
-			refCount: i
-		};
-	}
-	async indexCov(e, t, n, r) {
-		let i = 16384, a = t !== void 0, o = (await this.parse(r)).indices(e);
-		if (!o) return [];
-		let { linearIndex: s, stats: c } = o;
-		if (s.length === 0) return [];
-		let l = n === void 0 ? (s.length - 1) * i : C(n, i), u = t === void 0 ? 0 : S(t, i), d = a ? Array((l - u) / i) : Array(s.length - 1), f = s[s.length - 1].blockPosition;
-		if (l > (s.length - 1) * i) throw Error("query outside of range of linear index");
-		let p = s[u / i].blockPosition;
-		for (let e = u / i, t = 0; e < l / i; e++, t++) d[t] = {
-			score: s[e + 1].blockPosition - p,
-			start: e * i,
-			end: e * i + i
-		}, p = s[e + 1].blockPosition;
-		return d.map((e) => ({
-			...e,
-			score: e.score * (c?.lineCount || 0) / f
-		}));
-	}
-	async blocksForRange(e, t, n, r = {}) {
-		t < 0 && (t = 0);
-		let i = await this.parse(r);
-		if (!i) return [];
-		let a = i.indices(e);
-		if (!a) return [];
-		let o = w(t, n), s = [], { binIndex: c } = a;
-		for (let [e, t] of o) for (let n = e; n <= t; n++) {
-			let e = c[n];
-			if (e) for (let t = 0, n = e.length; t < n; t++) s.push(e[t]);
-		}
-		let { linearIndex: l } = a, d = l.length, f = l[Math.min(t >> 14, d - 1)];
-		return u(s, f);
-	}
-	async parse(e = {}) {
-		return this.setupP ||= this._parse(e).catch((e) => {
-			throw this.setupP = void 0, e;
-		}), this.setupP;
-	}
-	async hasRefSeq(e, t = {}) {
-		return !!(await this.parse(t)).indices(e)?.binIndex;
-	}
-}, E = [
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-	let n = t === 0 ? 0 : ~~t ^ -1;
-	for (let t = 0; t < e.length; t++) n = E[(n ^ e[t]) & 255] ^ n >>> 8;
-	return n ^ -1;
-}, O = 21582659, k = 38359875;
-function A(e, t) {
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-		super(...arguments), this.maxBinNumber = 0, this.depth = 0, this.minShift = 0;
-	}
-	async lineCount(e, t) {
-		return (await this.parse(t)).indices(e)?.stats?.lineCount || 0;
-	}
-	async indexCov() {
-		return [];
-	}
-	parseAuxData(e, t) {
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-			end: n.getInt32(t + 12, !0)
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-			coordinateType: i,
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-			metaChar: c,
-			skipLines: l,
-			format: a,
-			formatFlags: r,
-			...p(e.subarray(t + 28, t + 28 + u), this.renameRefSeq)
-		};
-	}
-	async _parse(t) {
-		let r = await e(await this.filehandle.readFile(t)), i = new DataView(r.buffer), o, s = i.getUint32(0, !0);
-		if (s === O) o = 1;
-		else if (s === k) o = 2;
-		else throw Error(`Not a CSI file ${s}`);
-		this.minShift = i.getInt32(4, !0), this.depth = i.getInt32(8, !0), this.maxBinNumber = ((1 << (this.depth + 1) * 3) - 1) / 7;
-		let c = this.maxBinNumber, l = i.getInt32(12, !0), u = l >= 30 ? this.parseAuxData(r, 16) : void 0, p = i.getInt32(16 + l, !0), m = 16 + l + 4, h, g = [];
-		for (let e = 0; e < p; e++) {
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-			let e = i.getInt32(m, !0);
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-			for (let t = 0; t < e; t++) {
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-					let e = i.getInt32(m, !0);
-					m += 4;
-					for (let t = 0; t < e; t += 1) {
-						let e = b(r, m);
-						m += 8, m += 8, h = f(h, e);
-					}
-				}
-			}
-		}
-		let _ = new n({ maxSize: 5 });
-		function v(e) {
-			let t = g[e];
-			if (t === void 0) return;
-			let n = i.getInt32(t, !0);
-			t += 4;
-			let o = {}, s;
-			for (let e = 0; e < n; e++) {
-				let e = i.getUint32(t, !0);
-				if (t += 4, e > c) s = d(r, t + 28), t += 44;
-				else {
-					h = f(h, b(r, t)), t += 8;
-					let n = i.getInt32(t, !0);
-					t += 4;
-					let s = Array(n);
-					for (let i = 0; i < n; i += 1) {
-						let n = b(r, t);
-						t += 8;
-						let o = b(r, t);
-						t += 8, s[i] = new a(n, o, e);
-					}
-					o[e] = s;
-				}
-			}
-			return {
-				binIndex: o,
-				stats: s
-			};
-		}
-		return {
-			csiVersion: o,
-			firstDataLine: h,
-			indices: (e) => {
-				if (!_.has(e)) {
-					let t = v(e);
-					return t && _.set(e, t), t;
-				}
-				return _.get(e);
-			},
-			refCount: p,
-			csi: !0,
-			maxBlockSize: 65536,
-			...u
-		};
-	}
-	async blocksForRange(e, t, n, r = {}) {
-		t < 0 && (t = 0);
-		let i = (await this.parse(r)).indices(e);
-		if (!i) return [];
-		let a = this.reg2bins(t, n);
-		if (a.length === 0) return [];
-		let o = [], { binIndex: s } = i;
-		for (let [e, t] of a) for (let n = e; n <= t; n++) {
-			let e = s[n];
-			if (e) for (let t = 0, n = e.length; t < n; t++) o.push(e[t]);
-		}
-		return u(o, new y(0, 0));
-	}
-	reg2bins(e, t) {
-		--e, e < 1 && (e = 1), t > 2 ** 50 && (t = 2 ** 34), --t;
-		let n = 0, r = 0, i = this.minShift + this.depth * 3, a = [];
-		for (; n <= this.depth; i -= 3, r += A(1, n * 3), n += 1) {
-			let n = r + j(e, i), o = r + j(t, i);
-			if (o - n + a.length > this.maxBinNumber) throw Error(`query ${e}-${t} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);
-			a.push([n, o]);
-		}
-		return a;
-	}
-	async parse(e = {}) {
-		return this.setupP ||= this._parse(e).catch((e) => {
-			throw this.setupP = void 0, e;
-		}), this.setupP;
-	}
-	async hasRefSeq(e, t = {}) {
-		return !!(await this.parse(t)).indices(e)?.binIndex;
-	}
-}, N = class {
-	read() {
-		throw Error("never called");
-	}
-	stat() {
-		throw Error("never called");
-	}
-	readFile() {
-		throw Error("never called");
-	}
-	close() {
-		throw Error("never called");
-	}
-}, P = {
-	BAM_FPAIRED: 1,
-	BAM_FPROPER_PAIR: 2,
-	BAM_FUNMAP: 4,
-	BAM_FMUNMAP: 8,
-	BAM_FREVERSE: 16,
-	BAM_FMREVERSE: 32,
-	BAM_FREAD1: 64,
-	BAM_FREAD2: 128,
-	BAM_FSECONDARY: 256,
-	BAM_FQCFAIL: 512,
-	BAM_FDUP: 1024,
-	BAM_FSUPPLEMENTARY: 2048
-}, F = "=ACMGRSVTWYHKDBN".split(""), I = /* @__PURE__ */ "F F .F R .R F .R R .F2F1.F2R1.R2F1.R2R1.F1F2.F1R2.R1F2.R1R2.F2F1.F2R1.R2F1.R2R1.F F .R F .F R .R R .F1F2.R1F2.F1R2.R1R2.F2F1.R2F1.F2R1.R2R1.F1F2.R1F2.F1R2.R1R2".split("."), L = [
-	77,
-	73,
-	68,
-	78,
-	83,
-	72,
-	80,
-	61,
-	88,
-	63,
-	63,
-	63,
-	63,
-	63,
-	63,
-	63
-], R = 461, z = class {
-	constructor(e) {
-		this.bytes = e.bytes, this.fileOffset = e.fileOffset, this._dataView = new DataView(this.bytes.byteArray.buffer);
-	}
-	get byteArray() {
-		return this.bytes.byteArray;
-	}
-	get flags() {
-		return this._cachedFlags === void 0 && (this._cachedFlags = (this._dataView.getInt32(this.bytes.start + 16, !0) & 4294901760) >> 16), this._cachedFlags;
-	}
-	get ref_id() {
-		return this._cachedRefId === void 0 && (this._cachedRefId = this._dataView.getInt32(this.bytes.start + 4, !0)), this._cachedRefId;
-	}
-	get start() {
-		return this._cachedStart === void 0 && (this._cachedStart = this._dataView.getInt32(this.bytes.start + 8, !0)), this._cachedStart;
-	}
-	get end() {
-		return this._cachedEnd === void 0 && (this._cachedEnd = this.start + this.length_on_ref), this._cachedEnd;
-	}
-	get mq() {
-		let e = (this.bin_mq_nl & 65280) >> 8;
-		return e === 255 ? void 0 : e;
-	}
-	get score() {
-		return this.mq;
-	}
-	get qual() {
-		if (this.isSegmentUnmapped()) return null;
-		{
-			let e = this.b0 + this.read_name_length + this.num_cigar_bytes + this.num_seq_bytes;
-			return this.byteArray.subarray(e, e + this.seq_length);
-		}
-	}
-	get strand() {
-		return this.isReverseComplemented() ? -1 : 1;
-	}
-	get b0() {
-		return this.bytes.start + 36;
-	}
-	get tagsStart() {
-		return this._cachedTagsStart === void 0 && (this._cachedTagsStart = this.b0 + this.read_name_length + this.num_cigar_bytes + this.num_seq_bytes + this.seq_length), this._cachedTagsStart;
-	}
-	get name() {
-		let e = this.read_name_length - 1, t = this.b0, n = this.byteArray, r = Array(e);
-		for (let i = 0; i < e; i++) r[i] = n[t + i];
-		return String.fromCharCode(...r);
-	}
-	get NUMERIC_MD() {
-		if (this._cachedNUMERIC_MD === void 0) {
-			let e = this.getTagRaw("MD");
-			this._cachedNUMERIC_MD = e instanceof Uint8Array ? e : null;
-		}
-		return this._cachedNUMERIC_MD === null ? void 0 : this._cachedNUMERIC_MD;
-	}
-	get tags() {
-		return this._cachedTags === void 0 && (this._cachedTags = this._computeTags()), this._cachedTags;
-	}
-	getTag(e) {
-		return this._cachedTags === void 0 ? this._findTag(e, !1) : this._cachedTags[e];
-	}
-	getTagRaw(e) {
-		return this._findTag(e, !0);
-	}
-	_findTag(e, t) {
-		let n = e.charCodeAt(0), r = e.charCodeAt(1), i = this.tagsStart, a = this.bytes.end, o = this.byteArray;
-		for (; i < a;) {
-			let e = o[i], s = o[i + 1], c = o[i + 2];
-			i += 3;
-			let l = e === n && s === r;
-			switch (c) {
-				case 65:
-					if (l) return String.fromCharCode(o[i]);
-					i += 1;
-					break;
-				case 105:
-					if (l) return this._dataView.getInt32(i, !0);
-					i += 4;
-					break;
-				case 73:
-					if (l) return this._dataView.getUint32(i, !0);
-					i += 4;
-					break;
-				case 99:
-					if (l) return this._dataView.getInt8(i);
-					i += 1;
-					break;
-				case 67:
-					if (l) return this._dataView.getUint8(i);
-					i += 1;
-					break;
-				case 115:
-					if (l) return this._dataView.getInt16(i, !0);
-					i += 2;
-					break;
-				case 83:
-					if (l) return this._dataView.getUint16(i, !0);
-					i += 2;
-					break;
-				case 102:
-					if (l) return this._dataView.getFloat32(i, !0);
-					i += 4;
-					break;
-				case 90:
-				case 72:
-					if (l) {
-						let e = i;
-						for (; i < a && o[i] !== 0;) i++;
-						if (t) return o.subarray(e, i);
-						let n = [];
-						for (let t = e; t < i; t++) n.push(String.fromCharCode(o[t]));
-						return n.join("");
-					}
-					for (; i <= a && o[i++] !== 0;);
-					break;
-				case 66: {
-					let e = o[i++], t = this._dataView.getInt32(i, !0);
-					i += 4;
-					let n = o.byteOffset + i;
-					if (l) {
-						if (e === 105) {
-							if (n % 4 == 0) return new Int32Array(o.buffer, n, t);
-							let e = Array(t);
-							for (let n = 0; n < t; n++) e[n] = this._dataView.getInt32(i + n * 4, !0);
-							return e;
-						} else if (e === 73) {
-							if (n % 4 == 0) return new Uint32Array(o.buffer, n, t);
-							let e = Array(t);
-							for (let n = 0; n < t; n++) e[n] = this._dataView.getUint32(i + n * 4, !0);
-							return e;
-						} else if (e === 115) {
-							if (n % 2 == 0) return new Int16Array(o.buffer, n, t);
-							let e = Array(t);
-							for (let n = 0; n < t; n++) e[n] = this._dataView.getInt16(i + n * 2, !0);
-							return e;
-						} else if (e === 83) {
-							if (n % 2 == 0) return new Uint16Array(o.buffer, n, t);
-							let e = Array(t);
-							for (let n = 0; n < t; n++) e[n] = this._dataView.getUint16(i + n * 2, !0);
-							return e;
-						} else if (e === 99) return new Int8Array(o.buffer, n, t);
-						else if (e === 67) return new Uint8Array(o.buffer, n, t);
-						else if (e === 102) {
-							if (n % 4 == 0) return new Float32Array(o.buffer, n, t);
-							let e = Array(t);
-							for (let n = 0; n < t; n++) e[n] = this._dataView.getFloat32(i + n * 4, !0);
-							return e;
-						}
-					}
-					e === 105 || e === 73 || e === 102 ? i += t << 2 : e === 115 || e === 83 ? i += t << 1 : (e === 99 || e === 67) && (i += t);
-					break;
-				}
-			}
-		}
-	}
-	_computeTags() {
-		let e = this.tagsStart, t = this.bytes.end, n = this.byteArray, r = {};
-		for (; e < t;) {
-			let i = String.fromCharCode(n[e], n[e + 1]), a = n[e + 2];
-			switch (e += 3, a) {
-				case 65:
-					r[i] = String.fromCharCode(n[e]), e += 1;
-					break;
-				case 105:
-					r[i] = this._dataView.getInt32(e, !0), e += 4;
-					break;
-				case 73:
-					r[i] = this._dataView.getUint32(e, !0), e += 4;
-					break;
-				case 99:
-					r[i] = this._dataView.getInt8(e), e += 1;
-					break;
-				case 67:
-					r[i] = this._dataView.getUint8(e), e += 1;
-					break;
-				case 115:
-					r[i] = this._dataView.getInt16(e, !0), e += 2;
-					break;
-				case 83:
-					r[i] = this._dataView.getUint16(e, !0), e += 2;
-					break;
-				case 102:
-					r[i] = this._dataView.getFloat32(e, !0), e += 4;
-					break;
-				case 90:
-				case 72: {
-					let a = [];
-					for (; e <= t;) {
-						let t = n[e++];
-						if (t !== 0) a.push(String.fromCharCode(t));
-						else break;
-					}
-					r[i] = a.join("");
-					break;
-				}
-				case 66: {
-					let t = n[e++], a = this._dataView.getInt32(e, !0);
-					e += 4;
-					let o = n.byteOffset + e;
-					if (t === 105) {
-						if (o % 4 == 0) r[i] = new Int32Array(n.buffer, o, a);
-						else {
-							let t = Array(a);
-							for (let n = 0; n < a; n++) t[n] = this._dataView.getInt32(e + n * 4, !0);
-							r[i] = t;
-						}
-						e += a << 2;
-					} else if (t === 73) {
-						if (o % 4 == 0) r[i] = new Uint32Array(n.buffer, o, a);
-						else {
-							let t = Array(a);
-							for (let n = 0; n < a; n++) t[n] = this._dataView.getUint32(e + n * 4, !0);
-							r[i] = t;
-						}
-						e += a << 2;
-					} else if (t === 115) {
-						if (o % 2 == 0) r[i] = new Int16Array(n.buffer, o, a);
-						else {
-							let t = Array(a);
-							for (let n = 0; n < a; n++) t[n] = this._dataView.getInt16(e + n * 2, !0);
-							r[i] = t;
-						}
-						e += a << 1;
-					} else if (t === 83) {
-						if (o % 2 == 0) r[i] = new Uint16Array(n.buffer, o, a);
-						else {
-							let t = Array(a);
-							for (let n = 0; n < a; n++) t[n] = this._dataView.getUint16(e + n * 2, !0);
-							r[i] = t;
-						}
-						e += a << 1;
-					} else if (t === 99) r[i] = new Int8Array(n.buffer, o, a), e += a;
-					else if (t === 67) r[i] = new Uint8Array(n.buffer, o, a), e += a;
-					else if (t === 102) {
-						if (o % 4 == 0) r[i] = new Float32Array(n.buffer, o, a);
-						else {
-							let t = Array(a);
-							for (let n = 0; n < a; n++) t[n] = this._dataView.getFloat32(e + n * 4, !0);
-							r[i] = t;
-						}
-						e += a << 2;
-					}
-					break;
-				}
-				default:
-					console.error("Unknown BAM tag type", a);
-					break;
-			}
-		}
-		return r;
-	}
-	isPaired() {
-		return !!(this.flags & P.BAM_FPAIRED);
-	}
-	isProperlyPaired() {
-		return !!(this.flags & P.BAM_FPROPER_PAIR);
-	}
-	isSegmentUnmapped() {
-		return !!(this.flags & P.BAM_FUNMAP);
-	}
-	isMateUnmapped() {
-		return !!(this.flags & P.BAM_FMUNMAP);
-	}
-	isReverseComplemented() {
-		return !!(this.flags & P.BAM_FREVERSE);
-	}
-	isMateReverseComplemented() {
-		return !!(this.flags & P.BAM_FMREVERSE);
-	}
-	isRead1() {
-		return !!(this.flags & P.BAM_FREAD1);
-	}
-	isRead2() {
-		return !!(this.flags & P.BAM_FREAD2);
-	}
-	isSecondary() {
-		return !!(this.flags & P.BAM_FSECONDARY);
-	}
-	isFailedQc() {
-		return !!(this.flags & P.BAM_FQCFAIL);
-	}
-	isDuplicate() {
-		return !!(this.flags & P.BAM_FDUP);
-	}
-	isSupplementary() {
-		return !!(this.flags & P.BAM_FSUPPLEMENTARY);
-	}
-	get cigarAndLength() {
-		return this._cachedCigarAndLength === void 0 && (this._cachedCigarAndLength = this._computeCigarAndLength()), this._cachedCigarAndLength;
-	}
-	_computeCigarAndLength() {
-		if (this.isSegmentUnmapped()) return {
-			length_on_ref: 0,
-			NUMERIC_CIGAR: new Uint32Array()
-		};
-		let e = this.num_cigar_ops, t = this.b0 + this.read_name_length, n = this._dataView.getInt32(t, !0), r = n >> 4;
-		if ((n & 15) == 4 && r === this.seq_length) {
-			t += 4;
-			let e = this._dataView.getInt32(t, !0), n = e >> 4;
-			return (e & 15) != 3 && console.warn("CG tag with no N tag"), {
-				NUMERIC_CIGAR: this.tags.CG,
-				length_on_ref: n
-			};
-		}
-		let i = this.byteArray.byteOffset + t;
-		if (i % 4 == 0 && e > 50) {
-			let t = new Uint32Array(this.byteArray.buffer, i, e), n = 0;
-			for (let r = 0; r < e; ++r) {
-				let e = t[r];
-				n += (e >> 4) * (R >> (e & 15) & 1);
-			}
-			return {
-				NUMERIC_CIGAR: t,
-				length_on_ref: n
-			};
-		}
-		let a = Array(e), o = 0;
-		for (let n = 0; n < e; ++n) {
-			let e = this._dataView.getInt32(t + n * 4, !0) | 0;
-			a[n] = e, o += (e >> 4) * (R >> (e & 15) & 1);
-		}
-		return {
-			NUMERIC_CIGAR: a,
-			length_on_ref: o
-		};
-	}
-	get length_on_ref() {
-		return this.cigarAndLength.length_on_ref;
-	}
-	get NUMERIC_CIGAR() {
-		return this.cigarAndLength.NUMERIC_CIGAR;
-	}
-	get CIGAR() {
-		let e = this.NUMERIC_CIGAR, t = "";
-		for (let n = 0, r = e.length; n < r; n++) {
-			let r = e[n], i = r >> 4, a = L[r & 15];
-			t += i + String.fromCharCode(a);
-		}
-		return t;
-	}
-	get num_cigar_ops() {
-		return this.flag_nc & 65535;
-	}
-	get num_cigar_bytes() {
-		return this.num_cigar_ops << 2;
-	}
-	get read_name_length() {
-		return this.bin_mq_nl & 255;
-	}
-	get num_seq_bytes() {
-		return this.seq_length + 1 >> 1;
-	}
-	get NUMERIC_SEQ() {
-		let e = this.b0 + this.read_name_length + this.num_cigar_bytes;
-		return this.byteArray.subarray(e, e + this.num_seq_bytes);
-	}
-	get seq() {
-		let e = this.NUMERIC_SEQ, t = this.seq_length, n = Array(t), r = 0, i = t >> 1;
-		for (let t = 0; t < i; ++t) {
-			let i = e[t];
-			n[r++] = F[(i & 240) >> 4], n[r++] = F[i & 15];
-		}
-		return r < t && (n[r] = F[(e[i] & 240) >> 4]), n.join("");
-	}
-	get pair_orientation() {
-		let e = this.flags;
-		if (!(e & 12 || this.ref_id !== this.next_refid)) return I[e >> 4 & 15 | (this.template_length > 0 ? 16 : 0)];
-	}
-	get bin_mq_nl() {
-		return this._dataView.getInt32(this.bytes.start + 12, !0);
-	}
-	get flag_nc() {
-		return this._dataView.getInt32(this.bytes.start + 16, !0);
-	}
-	get seq_length() {
-		return this._dataView.getInt32(this.bytes.start + 20, !0);
-	}
-	get next_refid() {
-		return this._dataView.getInt32(this.bytes.start + 24, !0);
-	}
-	get next_pos() {
-		return this._dataView.getInt32(this.bytes.start + 28, !0);
-	}
-	get template_length() {
-		return this._dataView.getInt32(this.bytes.start + 32, !0);
-	}
-	seqAt(e) {
-		if (e < this.seq_length) {
-			let t = e >> 1, n = this.byteArray[this.b0 + this.read_name_length + this.num_cigar_bytes + t];
-			return e % 2 == 0 ? F[(n & 240) >> 4] : F[n & 15];
-		} else return;
-	}
-	toJSON() {
-		let e = {};
-		for (let t of Object.keys(this)) t.startsWith("_") || t === "bytes" || (e[t] = this[t]);
-		return e;
-	}
-};
-//#endregion
-//#region ../../node_modules/@gmod/bam/esm/sam.js
-function B(e) {
-	let t = e.split(/\r?\n/), n = [];
-	for (let e of t) {
-		let [t, ...r] = e.split(/\t/);
-		t && n.push({
-			tag: t.slice(1),
-			data: r.map((e) => {
-				let t = e.indexOf(":");
-				return {
-					tag: e.slice(0, t),
-					value: e.slice(t + 1)
-				};
-			})
-		});
-	}
-	return n;
-}
-var V = 65536, H = class {
-	constructor({ bamFilehandle: e, bamPath: t, bamUrl: a, baiPath: o, baiFilehandle: s, baiUrl: c, csiPath: l, csiFilehandle: u, csiUrl: d, htsget: f, renameRefSeqs: p = (e) => e, recordClass: m }) {
-		if (this.htsget = !1, this.chunkFeatureCache = new n({ maxSize: 100 }), this.renameRefSeq = p, this.RecordClass = m ?? z, e) this.bam = e;
-		else if (t) this.bam = new i(t);
-		else if (a) this.bam = new r(a);
-		else if (f) this.htsget = !0, this.bam = new N();
-		else throw Error("unable to initialize bam");
-		if (u) this.index = new M({ filehandle: u });
-		else if (l) this.index = new M({ filehandle: new i(l) });
-		else if (d) this.index = new M({ filehandle: new r(d) });
-		else if (s) this.index = new T({ filehandle: s });
-		else if (o) this.index = new T({ filehandle: new i(o) });
-		else if (c) this.index = new T({ filehandle: new r(c) });
-		else if (t) this.index = new T({ filehandle: new i(`${t}.bai`) });
-		else if (a) this.index = new T({ filehandle: new r(`${a}.bai`) });
-		else if (f) this.htsget = !0;
-		else throw Error("unable to infer index format");
-	}
-	async getHeaderPre(t) {
-		let n = l(t);
-		if (!this.index) return;
-		let r = await this.index.parse(n), i = r.firstDataLine === void 0 ? void 0 : r.firstDataLine.blockPosition + V, a = await e(i === void 0 ? await this.bam.readFile() : await this.bam.read(i, 0)), o = new DataView(a.buffer);
-		if (o.getInt32(0, !0) !== 21840194) throw Error("Not a BAM file");
-		let s = o.getInt32(4, !0);
-		this.header = new TextDecoder("utf8").decode(a.subarray(8, 8 + s));
-		let c = s + 8;
-		for (let t = 0; t < 5; t++) {
-			if (this._hasEnoughRefSeqData(a, c)) {
-				let { chrToIndex: e, indexToChr: t } = this._parseRefSeqs(a, c);
-				return this.chrToIndex = e, this.indexToChr = t, B(this.header);
-			}
-			if (i === void 0) throw Error(`Insufficient data for reference sequences in ${a.length} bytes`);
-			i *= 2, a = await e(await this.bam.read(i, 0));
-		}
-		throw Error("Insufficient data for reference sequences after 5 retries");
-	}
-	getHeader(e) {
-		return this.headerP ||= this.getHeaderPre(e).catch((e) => {
-			throw this.headerP = void 0, e;
-		}), this.headerP;
-	}
-	async getHeaderText(e = {}) {
-		return await this.getHeader(e), this.header;
-	}
-	_hasEnoughRefSeqData(e, t) {
-		if (t + 4 > e.length) return !1;
-		let n = new DataView(e.buffer), r = n.getInt32(t, !0), i = t + 4;
-		for (let t = 0; t < r; t += 1) {
-			if (i + 8 > e.length) return !1;
-			let t = n.getInt32(i, !0);
-			i = i + 8 + t;
-		}
-		return !0;
-	}
-	_parseRefSeqs(e, t) {
-		let n = new DataView(e.buffer), r = n.getInt32(t, !0), i = t + 4, a = {}, o = [], s = new TextDecoder("utf8");
-		for (let t = 0; t < r; t += 1) {
-			let r = n.getInt32(i, !0), c = this.renameRefSeq(s.decode(e.subarray(i + 4, i + 4 + r - 1))), l = n.getInt32(i + r + 4, !0);
-			a[c] = t, o.push({
-				refName: c,
-				length: l
-			}), i = i + 8 + r;
-		}
-		return {
-			chrToIndex: a,
-			indexToChr: o
-		};
-	}
-	async getRecordsForRange(e, t, n, r) {
-		await this.getHeader(r);
-		let i = this.chrToIndex?.[e];
-		if (i === void 0 || !this.index) return [];
-		let a = await this.index.blocksForRange(i, t - 1, n, r);
-		return this._fetchChunkFeaturesDirect(a, i, t, n, r);
-	}
-	chunkCacheKey(e, t) {
-		let { minv: n, maxv: r } = e;
-		return `${n.blockPosition}:${n.dataPosition}-${r.blockPosition}:${r.dataPosition}${_(t)}`;
-	}
-	blocksOverlap(e, t, n, r) {
-		return e <= r && t >= n;
-	}
-	evictOverlappingChunks(e, t) {
-		for (let [n, r] of this.chunkFeatureCache) this.blocksOverlap(e, t, r.minBlock, r.maxBlock) && this.chunkFeatureCache.delete(n);
-	}
-	async _fetchChunkFeaturesDirect(e, t, n, r, i = {}) {
-		let { viewAsPairs: a, filterBy: o } = i, { flagInclude: s = 0, flagExclude: c = 0, tagFilter: l } = o || {}, u = [];
-		for (let a = 0, d = e.length; a < d; a++) {
-			let d = e[a], f = this.chunkCacheKey(d, o), p = d.minv.blockPosition, m = d.maxv.blockPosition, _, v = this.chunkFeatureCache.get(f);
-			if (v) _ = v.features;
-			else {
-				this.evictOverlappingChunks(p, m);
-				let { data: e, cpositions: t, dpositions: n } = await this._readChunk({
-					chunk: d,
-					opts: i
-				}), r = await this.readBamFeatures(e, t, n, d);
-				if (o) {
-					_ = [];
-					for (let e = 0, t = r.length; e < t; e++) {
-						let t = r[e];
-						h(t.flags, s, c) || l && g(t.tags[l.tag], l.value) || _.push(t);
-					}
-				} else _ = r;
-				this.chunkFeatureCache.set(f, {
-					minBlock: p,
-					maxBlock: m,
-					features: _
-				});
-			}
-			let y = !1;
-			for (let e = 0, i = _.length; e < i; e++) {
-				let i = _[e];
-				if (i.ref_id === t) if (i.start >= r) {
-					y = !0;
-					break;
-				} else i.end >= n && u.push(i);
-			}
-			if (y) break;
-		}
-		if (a) {
-			let e = await this.fetchPairs(t, u, i);
-			for (let t = 0, n = e.length; t < n; t++) u.push(e[t]);
-		}
-		return u;
-	}
-	async fetchPairs(e, t, n) {
-		let { pairAcrossChr: r, maxInsertSize: i = 2e5 } = n, a = {}, o = {};
-		for (let e = 0, n = t.length; e < n; e++) {
-			let n = t[e], r = n.name;
-			a[r] = (a[r] || 0) + 1, o[n.fileOffset] = 1;
-		}
-		let s = [];
-		for (let o = 0, c = t.length; o < c; o++) {
-			let c = t[o], l = c.name;
-			this.index && a[l] === 1 && (r || c.next_refid === e && Math.abs(c.start - c.next_pos) < i) && s.push(this.index.blocksForRange(c.next_refid, c.next_pos, c.next_pos + 1, n));
-		}
-		let c = /* @__PURE__ */ new Map(), l = await Promise.all(s);
-		for (let e = 0, t = l.length; e < t; e++) {
-			let t = l[e];
-			for (let e = 0, n = t.length; e < n; e++) {
-				let n = t[e], r = n.toString();
-				c.has(r) || c.set(r, n);
-			}
-		}
-		return (await Promise.all([...c.values()].map(async (e) => {
-			let { data: t, cpositions: r, dpositions: i, chunk: s } = await this._readChunk({
-				chunk: e,
-				opts: n
-			}), c = [], l = await this.readBamFeatures(t, r, i, s);
-			for (let e = 0, t = l.length; e < t; e++) {
-				let t = l[e];
-				a[t.name] === 1 && !o[t.fileOffset] && c.push(t);
-			}
-			return c;
-		}))).flat();
-	}
-	async _readChunk({ chunk: e, opts: n }) {
-		let { buffer: r, cpositions: i, dpositions: a } = await t(await this.bam.read(e.fetchedSize(), e.minv.blockPosition, n), e);
-		return {
-			data: r,
-			cpositions: i,
-			dpositions: a,
-			chunk: e
-		};
-	}
-	async readBamFeatures(e, t, n, r) {
-		let i = 0, a = [], o = 0, s = new DataView(e.buffer), c = n.length > 0, l = t.length > 0;
-		for (; i + 4 < e.length;) {
-			let u = s.getInt32(i, !0), d = i + 4 + u - 1;
-			if (c) {
-				for (; i + r.minv.dataPosition >= n[o++];);
-				o--;
-			}
-			if (d < e.length) {
-				let s = new this.RecordClass({
-					bytes: {
-						byteArray: e,
-						start: i,
-						end: d
-					},
-					fileOffset: l ? t[o] * 256 + (i - n[o]) + r.minv.dataPosition + 1 : D(e.subarray(i, d)) >>> 0
-				});
-				a.push(s);
-			}
-			i = d + 1;
-		}
-		return a;
-	}
-	async hasRefSeq(e) {
-		let t = this.chrToIndex?.[e];
-		return t === void 0 ? !1 : this.index?.hasRefSeq(t);
-	}
-	async lineCount(e) {
-		let t = this.chrToIndex?.[e];
-		return t === void 0 || !this.index ? 0 : this.index.lineCount(t);
-	}
-	async indexCov(e, t, n) {
-		if (!this.index) return [];
-		await this.index.parse();
-		let r = this.chrToIndex?.[e];
-		return r === void 0 ? [] : this.index.indexCov(r, t, n);
-	}
-	async blocksForRange(e, t, n, r) {
-		if (!this.index) return [];
-		await this.index.parse();
-		let i = this.chrToIndex?.[e];
-		return i === void 0 ? [] : this.index.blocksForRange(i, t, n, r);
-	}
-	clearFeatureCache() {
-		this.chunkFeatureCache.clear();
-	}
-	async estimatedBytesForRegions(e, t) {
-		if (!this.index) return 0;
-		if (await this.getHeader(t), !this.chrToIndex) throw Error("Header not yet parsed");
-		let n = e.flatMap((e) => {
-			let t = this.chrToIndex[e.refName];
-			return t === void 0 ? [] : [{
-				refId: t,
-				start: e.start,
-				end: e.end
-			}];
-		});
-		return this.index.estimatedBytesForRegions(n, t);
-	}
-};
-//#endregion
-//#region ../../node_modules/@gmod/bam/esm/htsget.js
-async function U(t, n) {
-	let r = await Promise.all(t.map(async (e) => {
-		let { url: t, headers: r } = e;
-		if (t.startsWith("data:")) {
-			let e = await fetch(t);
-			if (!e.ok) throw Error("failed to decode base64");
-			let n = await e.arrayBuffer();
-			return new Uint8Array(n);
-		} else {
-			let { referer: e, ...i } = r, a = await fetch(t, {
-				...n,
-				headers: {
-					...n?.headers,
-					...i
-				}
-			});
-			if (!a.ok) throw Error(`HTTP ${a.status} fetching ${t}: ${await a.text()}`);
-			return new Uint8Array(await a.arrayBuffer());
-		}
-	}));
-	return m(await Promise.all(r.map((t) => e(t))));
-}
-var W = class extends H {
-	constructor(e) {
-		super({
-			htsget: !0,
-			recordClass: e.recordClass
-		}), this.baseUrl = e.baseUrl, this.trackId = e.trackId;
-	}
-	async getRecordsForRange(e, t, n, r) {
-		let i = `${`${this.baseUrl}/${this.trackId}`}?referenceName=${e}&start=${t}&end=${n}&format=BAM`, a = this.chrToIndex?.[e];
-		if (a === void 0) return [];
-		let o = await fetch(i, { ...r });
-		if (!o.ok) throw Error(`HTTP ${o.status} fetching ${i}: ${await o.text()}`);
-		let s = await U((await o.json()).htsget.urls.slice(1), r), c = await this.readBamFeatures(s, [], [], {
-			minv: {
-				dataPosition: 0,
-				blockPosition: 0
-			},
-			maxv: {
-				dataPosition: 0,
-				blockPosition: 0
-			}
-		}), l = [];
-		for (let e = 0, r = c.length; e < r; e++) {
-			let r = c[e];
-			if (r.ref_id === a) {
-				if (r.start >= n) break;
-				r.end >= t && l.push(r);
-			}
-		}
-		return l;
-	}
-	async getHeader(e = {}) {
-		let t = `${this.baseUrl}/${this.trackId}?referenceName=na&class=header`, n = await fetch(t, e);
-		if (!n.ok) throw Error(`HTTP ${n.status} fetching ${t}: ${await n.text()}`);
-		let r = await U((await n.json()).htsget.urls, e), i = new DataView(r.buffer);
-		if (i.getInt32(0, !0) !== 21840194) throw Error("Not a BAM file");
-		let a = i.getInt32(4, !0), o = B(new TextDecoder("utf8").decode(r.subarray(8, 8 + a))), s = [], c = {}, l = o.filter((e) => e.tag === "SQ");
-		for (let [e, t] of l.entries()) {
-			let n = "", r = 0;
-			for (let e of t.data) e.tag === "SN" ? n = e.value : e.tag === "LN" && (r = +e.value);
-			c[n] = e, s[e] = {
-				refName: n,
-				length: r
-			};
-		}
-		return this.chrToIndex = c, this.indexToChr = s, o;
-	}
-};
-//#endregion
-export { T as BAI, H as BamFile, z as BamRecord, M as CSI, W as HtsgetFile };