@genome-spy/app 0.73.0 → 0.74.0

package/dist/esm-DCCYNvaz.js

@@ -0,0 +1,1426 @@
+import { t as e } from "./esm-CGX-qz1d.js";
+import { n as t, r as n } from "./esm-BDFRLEuD.js";
+import { r, t as i } from "./browser-Dvlo92rx.js";
+//#region ../../node_modules/@gmod/bam/esm/chunk.js
+var a = class {
+	constructor(e, t, n, r) {
+		this.minv = e, this.maxv = t, this.bin = n, this._fetchedSize = r;
+	}
+	toUniqueString() {
+		return `${this.minv.toString()}..${this.maxv.toString()} (bin ${this.bin}, fetchedSize ${this.fetchedSize()})`;
+	}
+	toString() {
+		return this.toUniqueString();
+	}
+	compareTo(e) {
+		return this.minv.compareTo(e.minv) || this.maxv.compareTo(e.maxv) || this.bin - e.bin;
+	}
+	fetchedSize() {
+		return this._fetchedSize === void 0 ? this.maxv.blockPosition + 65536 - this.minv.blockPosition : this._fetchedSize;
+	}
+}, o = 65536, s = o * o;
+function c(e, t = 0) {
+	let n = e[t] | e[t + 1] << 8 | e[t + 2] << 16 | e[t + 3] << 24;
+	return ((e[t + 4] | e[t + 5] << 8 | e[t + 6] << 16 | e[t + 7] << 24) >>> 0) * s + (n >>> 0);
+}
+//#endregion
+//#region ../../node_modules/@gmod/bam/esm/util.js
+function l(e = {}) {
+	return "aborted" in e ? { signal: e } : e;
+}
+function u(e, t) {
+	let n = e.length;
+	if (n === 0) return e;
+	let r;
+	if (t) {
+		let i = t.blockPosition, a = t.dataPosition;
+		r = [];
+		for (let t = 0; t < n; t++) {
+			let n = e[t], o = n.maxv;
+			(o.blockPosition - i || o.dataPosition - a) > 0 && r.push(n);
+		}
+		if (r.length === 0) return r;
+	} else r = e;
+	r.sort((e, t) => {
+		let n = e.minv.blockPosition - t.minv.blockPosition;
+		return n === 0 ? e.minv.dataPosition - t.minv.dataPosition : n;
+	});
+	let i = [], a = r[0];
+	i.push(a);
+	let o = a.minv.blockPosition, s = a.maxv.blockPosition;
+	for (let e = 1; e < r.length; e++) {
+		let t = r[e], n = t.minv.blockPosition, c = t.maxv.blockPosition;
+		if (n - s < 65e3 && c - o < 5e6) {
+			let e = t.maxv, n = a.maxv;
+			(c - s || e.dataPosition - n.dataPosition) > 0 && (a.maxv = e, s = c);
+		} else i.push(t), a = t, o = n, s = c;
+	}
+	return i;
+}
+function d(e, t) {
+	return { lineCount: c(e, t) };
+}
+function f(e, t) {
+	return e ? e.compareTo(t) > 0 ? t : e : t;
+}
+function p(e, t = (e) => e) {
+	let n = 0, r = 0, i = [], a = {};
+	for (let o = 0; o < e.length; o += 1) if (!e[o]) {
+		if (r < o) {
+			let s = "";
+			for (let t = r; t < o; t++) s += String.fromCharCode(e[t]);
+			s = t(s), i[n] = s, a[s] = n;
+		}
+		r = o + 1, n += 1;
+	}
+	return {
+		refNameToId: a,
+		refIdToName: i
+	};
+}
+function m(e) {
+	let t = 0;
+	for (let n of e) t += n.length;
+	let n = new Uint8Array(t), r = 0;
+	for (let t of e) n.set(t, r), r += t.length;
+	return n;
+}
+function h(e, t, n) {
+	return !!((e & t) !== t || e & n);
+}
+function g(e, t) {
+	return t === "*" ? e === void 0 : `${e}` != `${t}`;
+}
+function _(e) {
+	if (!e) return "";
+	let { flagInclude: t = 0, flagExclude: n = 0, tagFilter: r } = e;
+	return `:f${t}x${n}${r ? `:${r.tag}=${r.value ?? "*"}` : ""}`;
+}
+//#endregion
+//#region ../../node_modules/@gmod/bam/esm/indexFile.js
+var v = class {
+	constructor({ filehandle: e, renameRefSeq: t = (e) => e }) {
+		this.filehandle = e, this.renameRefSeq = t;
+	}
+	async estimatedBytesForRegions(e, t) {
+		let n = u((await Promise.all(e.map((e) => this.blocksForRange(e.refId, e.start, e.end, t)))).flat()), r = 0;
+		for (let e of n) r += e.fetchedSize();
+		return r;
+	}
+}, y = class {
+	constructor(e, t) {
+		this.blockPosition = e, this.dataPosition = t;
+	}
+	toString() {
+		return `${this.blockPosition}:${this.dataPosition}`;
+	}
+	compareTo(e) {
+		return this.blockPosition - e.blockPosition || this.dataPosition - e.dataPosition;
+	}
+};
+function b(e, t = 0, n = !1) {
+	if (n) throw Error("big-endian virtual file offsets not implemented");
+	return new y(e[t + 7] * 1099511627776 + e[t + 6] * 4294967296 + e[t + 5] * 16777216 + e[t + 4] * 65536 + e[t + 3] * 256 + e[t + 2], e[t + 1] << 8 | e[t]);
+}
+//#endregion
+//#region ../../node_modules/@gmod/bam/esm/bai.js
+var x = 21578050;
+function S(e, t) {
+	return e - e % t;
+}
+function C(e, t) {
+	return e - e % t + t;
+}
+function w(e, t) {
+	return --t, [
+		[0, 0],
+		[1 + (e >> 26), 1 + (t >> 26)],
+		[9 + (e >> 23), 9 + (t >> 23)],
+		[73 + (e >> 20), 73 + (t >> 20)],
+		[585 + (e >> 17), 585 + (t >> 17)],
+		[4681 + (e >> 14), 4681 + (t >> 14)]
+	];
+}
+var T = class extends v {
+	async lineCount(e, t) {
+		return (await this.parse(t)).indices(e)?.stats?.lineCount || 0;
+	}
+	async _parse(t) {
+		let n = await this.filehandle.readFile(), r = new DataView(n.buffer);
+		if (r.getUint32(0, !0) !== x) throw Error("Not a BAI file");
+		let i = r.getInt32(4, !0), o = ((1 << 18) - 1) / 7, s = 8, c, l = [];
+		for (let e = 0; e < i; e++) {
+			l.push(s);
+			let e = r.getInt32(s, !0);
+			s += 4;
+			for (let t = 0; t < e; t += 1) {
+				let e = r.getUint32(s, !0);
+				if (s += 4, e === o + 1) s += 4, s += 32;
+				else if (e > o + 1) throw Error("bai index contains too many bins, please use CSI");
+				else {
+					let e = r.getInt32(s, !0);
+					s += 4;
+					for (let t = 0; t < e; t++) s += 8, s += 8;
+				}
+			}
+			let t = r.getInt32(s, !0);
+			s += 4;
+			let i = Array(t);
+			for (let e = 0; e < t; e++) {
+				let t = b(n, s);
+				s += 8, c = f(c, t), i[e] = t;
+			}
+		}
+		let u = new e({ maxSize: 5 });
+		function p(e) {
+			let t = l[e];
+			if (t === void 0) return;
+			let i = r.getInt32(t, !0), s;
+			t += 4;
+			let u = {};
+			for (let e = 0; e < i; e += 1) {
+				let e = r.getUint32(t, !0);
+				if (t += 4, e === o + 1) t += 4, s = d(n, t + 16), t += 32;
+				else if (e > o + 1) throw Error("bai index contains too many bins, please use CSI");
+				else {
+					let i = r.getInt32(t, !0);
+					t += 4;
+					let o = Array(i);
+					for (let r = 0; r < i; r++) {
+						let i = b(n, t);
+						t += 8;
+						let s = b(n, t);
+						t += 8, c = f(c, i), o[r] = new a(i, s, e);
+					}
+					u[e] = o;
+				}
+			}
+			let p = r.getInt32(t, !0);
+			t += 4;
+			let m = Array(p);
+			for (let e = 0; e < p; e++) {
+				let r = b(n, t);
+				t += 8, c = f(c, r), m[e] = r;
+			}
+			return {
+				binIndex: u,
+				linearIndex: m,
+				stats: s
+			};
+		}
+		return {
+			bai: !0,
+			firstDataLine: c,
+			maxBlockSize: 65536,
+			indices: (e) => {
+				if (!u.has(e)) {
+					let t = p(e);
+					return t && u.set(e, t), t;
+				}
+				return u.get(e);
+			},
+			refCount: i
+		};
+	}
+	async indexCov(e, t, n, r) {
+		let i = 16384, a = t !== void 0, o = (await this.parse(r)).indices(e);
+		if (!o) return [];
+		let { linearIndex: s, stats: c } = o;
+		if (s.length === 0) return [];
+		let l = n === void 0 ? (s.length - 1) * i : C(n, i), u = t === void 0 ? 0 : S(t, i), d = a ? Array((l - u) / i) : Array(s.length - 1), f = s[s.length - 1].blockPosition;
+		if (l > (s.length - 1) * i) throw Error("query outside of range of linear index");
+		let p = s[u / i].blockPosition;
+		for (let e = u / i, t = 0; e < l / i; e++, t++) d[t] = {
+			score: s[e + 1].blockPosition - p,
+			start: e * i,
+			end: e * i + i
+		}, p = s[e + 1].blockPosition;
+		return d.map((e) => ({
+			...e,
+			score: e.score * (c?.lineCount || 0) / f
+		}));
+	}
+	async blocksForRange(e, t, n, r = {}) {
+		t < 0 && (t = 0);
+		let i = await this.parse(r);
+		if (!i) return [];
+		let a = i.indices(e);
+		if (!a) return [];
+		let o = w(t, n), s = [], { binIndex: c } = a;
+		for (let [e, t] of o) for (let n = e; n <= t; n++) {
+			let e = c[n];
+			if (e) for (let t = 0, n = e.length; t < n; t++) s.push(e[t]);
+		}
+		let { linearIndex: l } = a, d = l.length, f = l[Math.min(t >> 14, d - 1)];
+		return u(s, f);
+	}
+	async parse(e = {}) {
+		return this.setupP ||= this._parse(e).catch((e) => {
+			throw this.setupP = void 0, e;
+		}), this.setupP;
+	}
+	async hasRefSeq(e, t = {}) {
+		return !!(await this.parse(t)).indices(e)?.binIndex;
+	}
+}, E = [
+	0,
+	1996959894,
+	3993919788,
+	2567524794,
+	124634137,
+	1886057615,
+	3915621685,
+	2657392035,
+	249268274,
+	2044508324,
+	3772115230,
+	2547177864,
+	162941995,
+	2125561021,
+	3887607047,
+	2428444049,
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+	1789927666,
+	4089016648,
+	2227061214,
+	450548861,
+	1843258603,
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+	2344532202,
+	4240017532,
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+	1256170817,
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+	1141124467,
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+	1342533948,
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+	544179635,
+	3110523913,
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+	1957810842,
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+];
+typeof Int32Array < "u" && (E = new Int32Array(E));
+var D = (e, t) => {
+	let n = t === 0 ? 0 : ~~t ^ -1;
+	for (let t = 0; t < e.length; t++) n = E[(n ^ e[t]) & 255] ^ n >>> 8;
+	return n ^ -1;
+}, O = 21582659, k = 38359875;
+function A(e, t) {
+	return e * 2 ** t;
+}
+function j(e, t) {
+	return Math.floor(e / 2 ** t);
+}
+var M = class extends v {
+	constructor() {
+		super(...arguments), this.maxBinNumber = 0, this.depth = 0, this.minShift = 0;
+	}
+	async lineCount(e, t) {
+		return (await this.parse(t)).indices(e)?.stats?.lineCount || 0;
+	}
+	async indexCov() {
+		return [];
+	}
+	parseAuxData(e, t) {
+		let n = new DataView(e.buffer), r = n.getUint32(t, !0), i = r & 65536 ? "zero-based-half-open" : "1-based-closed", a = {
+			0: "generic",
+			1: "SAM",
+			2: "VCF"
+		}[r & 15];
+		if (!a) throw Error(`invalid Tabix preset format flags ${r}`);
+		let o = {
+			ref: n.getInt32(t + 4, !0),
+			start: n.getInt32(t + 8, !0),
+			end: n.getInt32(t + 12, !0)
+		}, s = n.getInt32(t + 16, !0), c = s ? String.fromCharCode(s) : "", l = n.getInt32(t + 20, !0), u = n.getInt32(t + 24, !0);
+		return {
+			columnNumbers: o,
+			coordinateType: i,
+			metaValue: s,
+			metaChar: c,
+			skipLines: l,
+			format: a,
+			formatFlags: r,
+			...p(e.subarray(t + 28, t + 28 + u), this.renameRefSeq)
+		};
+	}
+	async _parse(n) {
+		let r = await t(await this.filehandle.readFile(n)), i = new DataView(r.buffer), o, s = i.getUint32(0, !0);
+		if (s === O) o = 1;
+		else if (s === k) o = 2;
+		else throw Error(`Not a CSI file ${s}`);
+		this.minShift = i.getInt32(4, !0), this.depth = i.getInt32(8, !0), this.maxBinNumber = ((1 << (this.depth + 1) * 3) - 1) / 7;
+		let c = this.maxBinNumber, l = i.getInt32(12, !0), u = l >= 30 ? this.parseAuxData(r, 16) : void 0, p = i.getInt32(16 + l, !0), m = 16 + l + 4, h, g = [];
+		for (let e = 0; e < p; e++) {
+			g.push(m);
+			let e = i.getInt32(m, !0);
+			m += 4;
+			for (let t = 0; t < e; t++) {
+				let e = i.getUint32(m, !0);
+				if (m += 4, e > this.maxBinNumber) m += 44;
+				else {
+					m += 8;
+					let e = i.getInt32(m, !0);
+					m += 4;
+					for (let t = 0; t < e; t += 1) {
+						let e = b(r, m);
+						m += 8, m += 8, h = f(h, e);
+					}
+				}
+			}
+		}
+		let _ = new e({ maxSize: 5 });
+		function v(e) {
+			let t = g[e];
+			if (t === void 0) return;
+			let n = i.getInt32(t, !0);
+			t += 4;
+			let o = {}, s;
+			for (let e = 0; e < n; e++) {
+				let e = i.getUint32(t, !0);
+				if (t += 4, e > c) s = d(r, t + 28), t += 44;
+				else {
+					h = f(h, b(r, t)), t += 8;
+					let n = i.getInt32(t, !0);
+					t += 4;
+					let s = Array(n);
+					for (let i = 0; i < n; i += 1) {
+						let n = b(r, t);
+						t += 8;
+						let o = b(r, t);
+						t += 8, s[i] = new a(n, o, e);
+					}
+					o[e] = s;
+				}
+			}
+			return {
+				binIndex: o,
+				stats: s
+			};
+		}
+		return {
+			csiVersion: o,
+			firstDataLine: h,
+			indices: (e) => {
+				if (!_.has(e)) {
+					let t = v(e);
+					return t && _.set(e, t), t;
+				}
+				return _.get(e);
+			},
+			refCount: p,
+			csi: !0,
+			maxBlockSize: 65536,
+			...u
+		};
+	}
+	async blocksForRange(e, t, n, r = {}) {
+		t < 0 && (t = 0);
+		let i = (await this.parse(r)).indices(e);
+		if (!i) return [];
+		let a = this.reg2bins(t, n);
+		if (a.length === 0) return [];
+		let o = [], { binIndex: s } = i;
+		for (let [e, t] of a) for (let n = e; n <= t; n++) {
+			let e = s[n];
+			if (e) for (let t = 0, n = e.length; t < n; t++) o.push(e[t]);
+		}
+		return u(o, new y(0, 0));
+	}
+	reg2bins(e, t) {
+		--e, e < 1 && (e = 1), t > 2 ** 50 && (t = 2 ** 34), --t;
+		let n = 0, r = 0, i = this.minShift + this.depth * 3, a = [];
+		for (; n <= this.depth; i -= 3, r += A(1, n * 3), n += 1) {
+			let n = r + j(e, i), o = r + j(t, i);
+			if (o - n + a.length > this.maxBinNumber) throw Error(`query ${e}-${t} is too large for current binning scheme (shift ${this.minShift}, depth ${this.depth}), try a smaller query or a coarser index binning scheme`);
+			a.push([n, o]);
+		}
+		return a;
+	}
+	async parse(e = {}) {
+		return this.setupP ||= this._parse(e).catch((e) => {
+			throw this.setupP = void 0, e;
+		}), this.setupP;
+	}
+	async hasRefSeq(e, t = {}) {
+		return !!(await this.parse(t)).indices(e)?.binIndex;
+	}
+}, N = class {
+	read() {
+		throw Error("never called");
+	}
+	stat() {
+		throw Error("never called");
+	}
+	readFile() {
+		throw Error("never called");
+	}
+	close() {
+		throw Error("never called");
+	}
+}, P = {
+	BAM_FPAIRED: 1,
+	BAM_FPROPER_PAIR: 2,
+	BAM_FUNMAP: 4,
+	BAM_FMUNMAP: 8,
+	BAM_FREVERSE: 16,
+	BAM_FMREVERSE: 32,
+	BAM_FREAD1: 64,
+	BAM_FREAD2: 128,
+	BAM_FSECONDARY: 256,
+	BAM_FQCFAIL: 512,
+	BAM_FDUP: 1024,
+	BAM_FSUPPLEMENTARY: 2048
+}, F = "=ACMGRSVTWYHKDBN".split(""), I = /* @__PURE__ */ "F F .F R .R F .R R .F2F1.F2R1.R2F1.R2R1.F1F2.F1R2.R1F2.R1R2.F2F1.F2R1.R2F1.R2R1.F F .R F .F R .R R .F1F2.R1F2.F1R2.R1R2.F2F1.R2F1.F2R1.R2R1.F1F2.R1F2.F1R2.R1R2".split("."), L = [
+	77,
+	73,
+	68,
+	78,
+	83,
+	72,
+	80,
+	61,
+	88,
+	63,
+	63,
+	63,
+	63,
+	63,
+	63,
+	63
+], R = 461, z = class {
+	constructor(e) {
+		this.bytes = e.bytes, this.fileOffset = e.fileOffset, this._dataView = new DataView(this.bytes.byteArray.buffer);
+	}
+	get byteArray() {
+		return this.bytes.byteArray;
+	}
+	get flags() {
+		return this._cachedFlags === void 0 && (this._cachedFlags = (this._dataView.getInt32(this.bytes.start + 16, !0) & 4294901760) >> 16), this._cachedFlags;
+	}
+	get ref_id() {
+		return this._cachedRefId === void 0 && (this._cachedRefId = this._dataView.getInt32(this.bytes.start + 4, !0)), this._cachedRefId;
+	}
+	get start() {
+		return this._cachedStart === void 0 && (this._cachedStart = this._dataView.getInt32(this.bytes.start + 8, !0)), this._cachedStart;
+	}
+	get end() {
+		return this._cachedEnd === void 0 && (this._cachedEnd = this.start + this.length_on_ref), this._cachedEnd;
+	}
+	get mq() {
+		let e = (this.bin_mq_nl & 65280) >> 8;
+		return e === 255 ? void 0 : e;
+	}
+	get score() {
+		return this.mq;
+	}
+	get qual() {
+		if (this.isSegmentUnmapped()) return null;
+		{
+			let e = this.b0 + this.read_name_length + this.num_cigar_bytes + this.num_seq_bytes;
+			return this.byteArray.subarray(e, e + this.seq_length);
+		}
+	}
+	get strand() {
+		return this.isReverseComplemented() ? -1 : 1;
+	}
+	get b0() {
+		return this.bytes.start + 36;
+	}
+	get tagsStart() {
+		return this._cachedTagsStart === void 0 && (this._cachedTagsStart = this.b0 + this.read_name_length + this.num_cigar_bytes + this.num_seq_bytes + this.seq_length), this._cachedTagsStart;
+	}
+	get name() {
+		let e = this.read_name_length - 1, t = this.b0, n = this.byteArray, r = Array(e);
+		for (let i = 0; i < e; i++) r[i] = n[t + i];
+		return String.fromCharCode(...r);
+	}
+	get NUMERIC_MD() {
+		if (this._cachedNUMERIC_MD === void 0) {
+			let e = this.getTagRaw("MD");
+			this._cachedNUMERIC_MD = e instanceof Uint8Array ? e : null;
+		}
+		return this._cachedNUMERIC_MD === null ? void 0 : this._cachedNUMERIC_MD;
+	}
+	get tags() {
+		return this._cachedTags === void 0 && (this._cachedTags = this._computeTags()), this._cachedTags;
+	}
+	getTag(e) {
+		return this._cachedTags === void 0 ? this._findTag(e, !1) : this._cachedTags[e];
+	}
+	getTagRaw(e) {
+		return this._findTag(e, !0);
+	}
+	_findTag(e, t) {
+		let n = e.charCodeAt(0), r = e.charCodeAt(1), i = this.tagsStart, a = this.bytes.end, o = this.byteArray;
+		for (; i < a;) {
+			let e = o[i], s = o[i + 1], c = o[i + 2];
+			i += 3;
+			let l = e === n && s === r;
+			switch (c) {
+				case 65:
+					if (l) return String.fromCharCode(o[i]);
+					i += 1;
+					break;
+				case 105:
+					if (l) return this._dataView.getInt32(i, !0);
+					i += 4;
+					break;
+				case 73:
+					if (l) return this._dataView.getUint32(i, !0);
+					i += 4;
+					break;
+				case 99:
+					if (l) return this._dataView.getInt8(i);
+					i += 1;
+					break;
+				case 67:
+					if (l) return this._dataView.getUint8(i);
+					i += 1;
+					break;
+				case 115:
+					if (l) return this._dataView.getInt16(i, !0);
+					i += 2;
+					break;
+				case 83:
+					if (l) return this._dataView.getUint16(i, !0);
+					i += 2;
+					break;
+				case 102:
+					if (l) return this._dataView.getFloat32(i, !0);
+					i += 4;
+					break;
+				case 90:
+				case 72:
+					if (l) {
+						let e = i;
+						for (; i < a && o[i] !== 0;) i++;
+						if (t) return o.subarray(e, i);
+						let n = [];
+						for (let t = e; t < i; t++) n.push(String.fromCharCode(o[t]));
+						return n.join("");
+					}
+					for (; i <= a && o[i++] !== 0;);
+					break;
+				case 66: {
+					let e = o[i++], t = this._dataView.getInt32(i, !0);
+					i += 4;
+					let n = o.byteOffset + i;
+					if (l) {
+						if (e === 105) {
+							if (n % 4 == 0) return new Int32Array(o.buffer, n, t);
+							let e = Array(t);
+							for (let n = 0; n < t; n++) e[n] = this._dataView.getInt32(i + n * 4, !0);
+							return e;
+						} else if (e === 73) {
+							if (n % 4 == 0) return new Uint32Array(o.buffer, n, t);
+							let e = Array(t);
+							for (let n = 0; n < t; n++) e[n] = this._dataView.getUint32(i + n * 4, !0);
+							return e;
+						} else if (e === 115) {
+							if (n % 2 == 0) return new Int16Array(o.buffer, n, t);
+							let e = Array(t);
+							for (let n = 0; n < t; n++) e[n] = this._dataView.getInt16(i + n * 2, !0);
+							return e;
+						} else if (e === 83) {
+							if (n % 2 == 0) return new Uint16Array(o.buffer, n, t);
+							let e = Array(t);
+							for (let n = 0; n < t; n++) e[n] = this._dataView.getUint16(i + n * 2, !0);
+							return e;
+						} else if (e === 99) return new Int8Array(o.buffer, n, t);
+						else if (e === 67) return new Uint8Array(o.buffer, n, t);
+						else if (e === 102) {
+							if (n % 4 == 0) return new Float32Array(o.buffer, n, t);
+							let e = Array(t);
+							for (let n = 0; n < t; n++) e[n] = this._dataView.getFloat32(i + n * 4, !0);
+							return e;
+						}
+					}
+					e === 105 || e === 73 || e === 102 ? i += t << 2 : e === 115 || e === 83 ? i += t << 1 : (e === 99 || e === 67) && (i += t);
+					break;
+				}
+			}
+		}
+	}
+	_computeTags() {
+		let e = this.tagsStart, t = this.bytes.end, n = this.byteArray, r = {};
+		for (; e < t;) {
+			let i = String.fromCharCode(n[e], n[e + 1]), a = n[e + 2];
+			switch (e += 3, a) {
+				case 65:
+					r[i] = String.fromCharCode(n[e]), e += 1;
+					break;
+				case 105:
+					r[i] = this._dataView.getInt32(e, !0), e += 4;
+					break;
+				case 73:
+					r[i] = this._dataView.getUint32(e, !0), e += 4;
+					break;
+				case 99:
+					r[i] = this._dataView.getInt8(e), e += 1;
+					break;
+				case 67:
+					r[i] = this._dataView.getUint8(e), e += 1;
+					break;
+				case 115:
+					r[i] = this._dataView.getInt16(e, !0), e += 2;
+					break;
+				case 83:
+					r[i] = this._dataView.getUint16(e, !0), e += 2;
+					break;
+				case 102:
+					r[i] = this._dataView.getFloat32(e, !0), e += 4;
+					break;
+				case 90:
+				case 72: {
+					let a = [];
+					for (; e <= t;) {
+						let t = n[e++];
+						if (t !== 0) a.push(String.fromCharCode(t));
+						else break;
+					}
+					r[i] = a.join("");
+					break;
+				}
+				case 66: {
+					let t = n[e++], a = this._dataView.getInt32(e, !0);
+					e += 4;
+					let o = n.byteOffset + e;
+					if (t === 105) {
+						if (o % 4 == 0) r[i] = new Int32Array(n.buffer, o, a);
+						else {
+							let t = Array(a);
+							for (let n = 0; n < a; n++) t[n] = this._dataView.getInt32(e + n * 4, !0);
+							r[i] = t;
+						}
+						e += a << 2;
+					} else if (t === 73) {
+						if (o % 4 == 0) r[i] = new Uint32Array(n.buffer, o, a);
+						else {
+							let t = Array(a);
+							for (let n = 0; n < a; n++) t[n] = this._dataView.getUint32(e + n * 4, !0);
+							r[i] = t;
+						}
+						e += a << 2;
+					} else if (t === 115) {
+						if (o % 2 == 0) r[i] = new Int16Array(n.buffer, o, a);
+						else {
+							let t = Array(a);
+							for (let n = 0; n < a; n++) t[n] = this._dataView.getInt16(e + n * 2, !0);
+							r[i] = t;
+						}
+						e += a << 1;
+					} else if (t === 83) {
+						if (o % 2 == 0) r[i] = new Uint16Array(n.buffer, o, a);
+						else {
+							let t = Array(a);
+							for (let n = 0; n < a; n++) t[n] = this._dataView.getUint16(e + n * 2, !0);
+							r[i] = t;
+						}
+						e += a << 1;
+					} else if (t === 99) r[i] = new Int8Array(n.buffer, o, a), e += a;
+					else if (t === 67) r[i] = new Uint8Array(n.buffer, o, a), e += a;
+					else if (t === 102) {
+						if (o % 4 == 0) r[i] = new Float32Array(n.buffer, o, a);
+						else {
+							let t = Array(a);
+							for (let n = 0; n < a; n++) t[n] = this._dataView.getFloat32(e + n * 4, !0);
+							r[i] = t;
+						}
+						e += a << 2;
+					}
+					break;
+				}
+				default:
+					console.error("Unknown BAM tag type", a);
+					break;
+			}
+		}
+		return r;
+	}
+	isPaired() {
+		return !!(this.flags & P.BAM_FPAIRED);
+	}
+	isProperlyPaired() {
+		return !!(this.flags & P.BAM_FPROPER_PAIR);
+	}
+	isSegmentUnmapped() {
+		return !!(this.flags & P.BAM_FUNMAP);
+	}
+	isMateUnmapped() {
+		return !!(this.flags & P.BAM_FMUNMAP);
+	}
+	isReverseComplemented() {
+		return !!(this.flags & P.BAM_FREVERSE);
+	}
+	isMateReverseComplemented() {
+		return !!(this.flags & P.BAM_FMREVERSE);
+	}
+	isRead1() {
+		return !!(this.flags & P.BAM_FREAD1);
+	}
+	isRead2() {
+		return !!(this.flags & P.BAM_FREAD2);
+	}
+	isSecondary() {
+		return !!(this.flags & P.BAM_FSECONDARY);
+	}
+	isFailedQc() {
+		return !!(this.flags & P.BAM_FQCFAIL);
+	}
+	isDuplicate() {
+		return !!(this.flags & P.BAM_FDUP);
+	}
+	isSupplementary() {
+		return !!(this.flags & P.BAM_FSUPPLEMENTARY);
+	}
+	get cigarAndLength() {
+		return this._cachedCigarAndLength === void 0 && (this._cachedCigarAndLength = this._computeCigarAndLength()), this._cachedCigarAndLength;
+	}
+	_computeCigarAndLength() {
+		if (this.isSegmentUnmapped()) return {
+			length_on_ref: 0,
+			NUMERIC_CIGAR: new Uint32Array()
+		};
+		let e = this.num_cigar_ops, t = this.b0 + this.read_name_length, n = this._dataView.getInt32(t, !0), r = n >> 4;
+		if ((n & 15) == 4 && r === this.seq_length) {
+			t += 4;
+			let e = this._dataView.getInt32(t, !0), n = e >> 4;
+			return (e & 15) != 3 && console.warn("CG tag with no N tag"), {
+				NUMERIC_CIGAR: this.tags.CG,
+				length_on_ref: n
+			};
+		}
+		let i = this.byteArray.byteOffset + t;
+		if (i % 4 == 0 && e > 50) {
+			let t = new Uint32Array(this.byteArray.buffer, i, e), n = 0;
+			for (let r = 0; r < e; ++r) {
+				let e = t[r];
+				n += (e >> 4) * (R >> (e & 15) & 1);
+			}
+			return {
+				NUMERIC_CIGAR: t,
+				length_on_ref: n
+			};
+		}
+		let a = Array(e), o = 0;
+		for (let n = 0; n < e; ++n) {
+			let e = this._dataView.getInt32(t + n * 4, !0) | 0;
+			a[n] = e, o += (e >> 4) * (R >> (e & 15) & 1);
+		}
+		return {
+			NUMERIC_CIGAR: a,
+			length_on_ref: o
+		};
+	}
+	get length_on_ref() {
+		return this.cigarAndLength.length_on_ref;
+	}
+	get NUMERIC_CIGAR() {
+		return this.cigarAndLength.NUMERIC_CIGAR;
+	}
+	get CIGAR() {
+		let e = this.NUMERIC_CIGAR, t = "";
+		for (let n = 0, r = e.length; n < r; n++) {
+			let r = e[n], i = r >> 4, a = L[r & 15];
+			t += i + String.fromCharCode(a);
+		}
+		return t;
+	}
+	get num_cigar_ops() {
+		return this.flag_nc & 65535;
+	}
+	get num_cigar_bytes() {
+		return this.num_cigar_ops << 2;
+	}
+	get read_name_length() {
+		return this.bin_mq_nl & 255;
+	}
+	get num_seq_bytes() {
+		return this.seq_length + 1 >> 1;
+	}
+	get NUMERIC_SEQ() {
+		let e = this.b0 + this.read_name_length + this.num_cigar_bytes;
+		return this.byteArray.subarray(e, e + this.num_seq_bytes);
+	}
+	get seq() {
+		let e = this.NUMERIC_SEQ, t = this.seq_length, n = Array(t), r = 0, i = t >> 1;
+		for (let t = 0; t < i; ++t) {
+			let i = e[t];
+			n[r++] = F[(i & 240) >> 4], n[r++] = F[i & 15];
+		}
+		return r < t && (n[r] = F[(e[i] & 240) >> 4]), n.join("");
+	}
+	get pair_orientation() {
+		let e = this.flags;
+		if (!(e & 12 || this.ref_id !== this.next_refid)) return I[e >> 4 & 15 | (this.template_length > 0 ? 16 : 0)];
+	}
+	get bin_mq_nl() {
+		return this._dataView.getInt32(this.bytes.start + 12, !0);
+	}
+	get flag_nc() {
+		return this._dataView.getInt32(this.bytes.start + 16, !0);
+	}
+	get seq_length() {
+		return this._dataView.getInt32(this.bytes.start + 20, !0);
+	}
+	get next_refid() {
+		return this._dataView.getInt32(this.bytes.start + 24, !0);
+	}
+	get next_pos() {
+		return this._dataView.getInt32(this.bytes.start + 28, !0);
+	}
+	get template_length() {
+		return this._dataView.getInt32(this.bytes.start + 32, !0);
+	}
+	seqAt(e) {
+		if (e < this.seq_length) {
+			let t = e >> 1, n = this.byteArray[this.b0 + this.read_name_length + this.num_cigar_bytes + t];
+			return e % 2 == 0 ? F[(n & 240) >> 4] : F[n & 15];
+		} else return;
+	}
+	toJSON() {
+		let e = {};
+		for (let t of Object.keys(this)) t.startsWith("_") || t === "bytes" || (e[t] = this[t]);
+		return e;
+	}
+};
+//#endregion
+//#region ../../node_modules/@gmod/bam/esm/sam.js
+function B(e) {
+	let t = e.split(/\r?\n/), n = [];
+	for (let e of t) {
+		let [t, ...r] = e.split(/\t/);
+		t && n.push({
+			tag: t.slice(1),
+			data: r.map((e) => {
+				let t = e.indexOf(":");
+				return {
+					tag: e.slice(0, t),
+					value: e.slice(t + 1)
+				};
+			})
+		});
+	}
+	return n;
+}
+var V = 65536, H = class {
+	constructor({ bamFilehandle: t, bamPath: n, bamUrl: a, baiPath: o, baiFilehandle: s, baiUrl: c, csiPath: l, csiFilehandle: u, csiUrl: d, htsget: f, renameRefSeqs: p = (e) => e, recordClass: m }) {
+		if (this.htsget = !1, this.chunkFeatureCache = new e({ maxSize: 100 }), this.renameRefSeq = p, this.RecordClass = m ?? z, t) this.bam = t;
+		else if (n) this.bam = new i(n);
+		else if (a) this.bam = new r(a);
+		else if (f) this.htsget = !0, this.bam = new N();
+		else throw Error("unable to initialize bam");
+		if (u) this.index = new M({ filehandle: u });
+		else if (l) this.index = new M({ filehandle: new i(l) });
+		else if (d) this.index = new M({ filehandle: new r(d) });
+		else if (s) this.index = new T({ filehandle: s });
+		else if (o) this.index = new T({ filehandle: new i(o) });
+		else if (c) this.index = new T({ filehandle: new r(c) });
+		else if (n) this.index = new T({ filehandle: new i(`${n}.bai`) });
+		else if (a) this.index = new T({ filehandle: new r(`${a}.bai`) });
+		else if (f) this.htsget = !0;
+		else throw Error("unable to infer index format");
+	}
+	async getHeaderPre(e) {
+		let n = l(e);
+		if (!this.index) return;
+		let r = await this.index.parse(n), i = r.firstDataLine === void 0 ? void 0 : r.firstDataLine.blockPosition + V, a = await t(i === void 0 ? await this.bam.readFile() : await this.bam.read(i, 0)), o = new DataView(a.buffer);
+		if (o.getInt32(0, !0) !== 21840194) throw Error("Not a BAM file");
+		let s = o.getInt32(4, !0);
+		this.header = new TextDecoder("utf8").decode(a.subarray(8, 8 + s));
+		let c = s + 8;
+		for (let e = 0; e < 5; e++) {
+			if (this._hasEnoughRefSeqData(a, c)) {
+				let { chrToIndex: e, indexToChr: t } = this._parseRefSeqs(a, c);
+				return this.chrToIndex = e, this.indexToChr = t, B(this.header);
+			}
+			if (i === void 0) throw Error(`Insufficient data for reference sequences in ${a.length} bytes`);
+			i *= 2, a = await t(await this.bam.read(i, 0));
+		}
+		throw Error("Insufficient data for reference sequences after 5 retries");
+	}
+	getHeader(e) {
+		return this.headerP ||= this.getHeaderPre(e).catch((e) => {
+			throw this.headerP = void 0, e;
+		}), this.headerP;
+	}
+	async getHeaderText(e = {}) {
+		return await this.getHeader(e), this.header;
+	}
+	_hasEnoughRefSeqData(e, t) {
+		if (t + 4 > e.length) return !1;
+		let n = new DataView(e.buffer), r = n.getInt32(t, !0), i = t + 4;
+		for (let t = 0; t < r; t += 1) {
+			if (i + 8 > e.length) return !1;
+			let t = n.getInt32(i, !0);
+			i = i + 8 + t;
+		}
+		return !0;
+	}
+	_parseRefSeqs(e, t) {
+		let n = new DataView(e.buffer), r = n.getInt32(t, !0), i = t + 4, a = {}, o = [], s = new TextDecoder("utf8");
+		for (let t = 0; t < r; t += 1) {
+			let r = n.getInt32(i, !0), c = this.renameRefSeq(s.decode(e.subarray(i + 4, i + 4 + r - 1))), l = n.getInt32(i + r + 4, !0);
+			a[c] = t, o.push({
+				refName: c,
+				length: l
+			}), i = i + 8 + r;
+		}
+		return {
+			chrToIndex: a,
+			indexToChr: o
+		};
+	}
+	async getRecordsForRange(e, t, n, r) {
+		await this.getHeader(r);
+		let i = this.chrToIndex?.[e];
+		if (i === void 0 || !this.index) return [];
+		let a = await this.index.blocksForRange(i, t - 1, n, r);
+		return this._fetchChunkFeaturesDirect(a, i, t, n, r);
+	}
+	chunkCacheKey(e, t) {
+		let { minv: n, maxv: r } = e;
+		return `${n.blockPosition}:${n.dataPosition}-${r.blockPosition}:${r.dataPosition}${_(t)}`;
+	}
+	blocksOverlap(e, t, n, r) {
+		return e <= r && t >= n;
+	}
+	evictOverlappingChunks(e, t) {
+		for (let [n, r] of this.chunkFeatureCache) this.blocksOverlap(e, t, r.minBlock, r.maxBlock) && this.chunkFeatureCache.delete(n);
+	}
+	async _fetchChunkFeaturesDirect(e, t, n, r, i = {}) {
+		let { viewAsPairs: a, filterBy: o } = i, { flagInclude: s = 0, flagExclude: c = 0, tagFilter: l } = o || {}, u = [];
+		for (let a = 0, d = e.length; a < d; a++) {
+			let d = e[a], f = this.chunkCacheKey(d, o), p = d.minv.blockPosition, m = d.maxv.blockPosition, _, v = this.chunkFeatureCache.get(f);
+			if (v) _ = v.features;
+			else {
+				this.evictOverlappingChunks(p, m);
+				let { data: e, cpositions: t, dpositions: n } = await this._readChunk({
+					chunk: d,
+					opts: i
+				}), r = await this.readBamFeatures(e, t, n, d);
+				if (o) {
+					_ = [];
+					for (let e = 0, t = r.length; e < t; e++) {
+						let t = r[e];
+						h(t.flags, s, c) || l && g(t.tags[l.tag], l.value) || _.push(t);
+					}
+				} else _ = r;
+				this.chunkFeatureCache.set(f, {
+					minBlock: p,
+					maxBlock: m,
+					features: _
+				});
+			}
+			let y = !1;
+			for (let e = 0, i = _.length; e < i; e++) {
+				let i = _[e];
+				if (i.ref_id === t) if (i.start >= r) {
+					y = !0;
+					break;
+				} else i.end >= n && u.push(i);
+			}
+			if (y) break;
+		}
+		if (a) {
+			let e = await this.fetchPairs(t, u, i);
+			for (let t = 0, n = e.length; t < n; t++) u.push(e[t]);
+		}
+		return u;
+	}
+	async fetchPairs(e, t, n) {
+		let { pairAcrossChr: r, maxInsertSize: i = 2e5 } = n, a = {}, o = {};
+		for (let e = 0, n = t.length; e < n; e++) {
+			let n = t[e], r = n.name;
+			a[r] = (a[r] || 0) + 1, o[n.fileOffset] = 1;
+		}
+		let s = [];
+		for (let o = 0, c = t.length; o < c; o++) {
+			let c = t[o], l = c.name;
+			this.index && a[l] === 1 && (r || c.next_refid === e && Math.abs(c.start - c.next_pos) < i) && s.push(this.index.blocksForRange(c.next_refid, c.next_pos, c.next_pos + 1, n));
+		}
+		let c = /* @__PURE__ */ new Map(), l = await Promise.all(s);
+		for (let e = 0, t = l.length; e < t; e++) {
+			let t = l[e];
+			for (let e = 0, n = t.length; e < n; e++) {
+				let n = t[e], r = n.toString();
+				c.has(r) || c.set(r, n);
+			}
+		}
+		return (await Promise.all([...c.values()].map(async (e) => {
+			let { data: t, cpositions: r, dpositions: i, chunk: s } = await this._readChunk({
+				chunk: e,
+				opts: n
+			}), c = [], l = await this.readBamFeatures(t, r, i, s);
+			for (let e = 0, t = l.length; e < t; e++) {
+				let t = l[e];
+				a[t.name] === 1 && !o[t.fileOffset] && c.push(t);
+			}
+			return c;
+		}))).flat();
+	}
+	async _readChunk({ chunk: e, opts: t }) {
+		let { buffer: r, cpositions: i, dpositions: a } = await n(await this.bam.read(e.fetchedSize(), e.minv.blockPosition, t), e);
+		return {
+			data: r,
+			cpositions: i,
+			dpositions: a,
+			chunk: e
+		};
+	}
+	async readBamFeatures(e, t, n, r) {
+		let i = 0, a = [], o = 0, s = new DataView(e.buffer), c = n.length > 0, l = t.length > 0;
+		for (; i + 4 < e.length;) {
+			let u = s.getInt32(i, !0), d = i + 4 + u - 1;
+			if (c) {
+				for (; i + r.minv.dataPosition >= n[o++];);
+				o--;
+			}
+			if (d < e.length) {
+				let s = new this.RecordClass({
+					bytes: {
+						byteArray: e,
+						start: i,
+						end: d
+					},
+					fileOffset: l ? t[o] * 256 + (i - n[o]) + r.minv.dataPosition + 1 : D(e.subarray(i, d)) >>> 0
+				});
+				a.push(s);
+			}
+			i = d + 1;
+		}
+		return a;
+	}
+	async hasRefSeq(e) {
+		let t = this.chrToIndex?.[e];
+		return t === void 0 ? !1 : this.index?.hasRefSeq(t);
+	}
+	async lineCount(e) {
+		let t = this.chrToIndex?.[e];
+		return t === void 0 || !this.index ? 0 : this.index.lineCount(t);
+	}
+	async indexCov(e, t, n) {
+		if (!this.index) return [];
+		await this.index.parse();
+		let r = this.chrToIndex?.[e];
+		return r === void 0 ? [] : this.index.indexCov(r, t, n);
+	}
+	async blocksForRange(e, t, n, r) {
+		if (!this.index) return [];
+		await this.index.parse();
+		let i = this.chrToIndex?.[e];
+		return i === void 0 ? [] : this.index.blocksForRange(i, t, n, r);
+	}
+	clearFeatureCache() {
+		this.chunkFeatureCache.clear();
+	}
+	async estimatedBytesForRegions(e, t) {
+		if (!this.index) return 0;
+		if (await this.getHeader(t), !this.chrToIndex) throw Error("Header not yet parsed");
+		let n = e.flatMap((e) => {
+			let t = this.chrToIndex[e.refName];
+			return t === void 0 ? [] : [{
+				refId: t,
+				start: e.start,
+				end: e.end
+			}];
+		});
+		return this.index.estimatedBytesForRegions(n, t);
+	}
+};
+//#endregion
+//#region ../../node_modules/@gmod/bam/esm/htsget.js
+async function U(e, n) {
+	let r = await Promise.all(e.map(async (e) => {
+		let { url: t, headers: r } = e;
+		if (t.startsWith("data:")) {
+			let e = await fetch(t);
+			if (!e.ok) throw Error("failed to decode base64");
+			let n = await e.arrayBuffer();
+			return new Uint8Array(n);
+		} else {
+			let { referer: e, ...i } = r, a = await fetch(t, {
+				...n,
+				headers: {
+					...n?.headers,
+					...i
+				}
+			});
+			if (!a.ok) throw Error(`HTTP ${a.status} fetching ${t}: ${await a.text()}`);
+			return new Uint8Array(await a.arrayBuffer());
+		}
+	}));
+	return m(await Promise.all(r.map((e) => t(e))));
+}
+var W = class extends H {
+	constructor(e) {
+		super({
+			htsget: !0,
+			recordClass: e.recordClass
+		}), this.baseUrl = e.baseUrl, this.trackId = e.trackId;
+	}
+	async getRecordsForRange(e, t, n, r) {
+		let i = `${`${this.baseUrl}/${this.trackId}`}?referenceName=${e}&start=${t}&end=${n}&format=BAM`, a = this.chrToIndex?.[e];
+		if (a === void 0) return [];
+		let o = await fetch(i, { ...r });
+		if (!o.ok) throw Error(`HTTP ${o.status} fetching ${i}: ${await o.text()}`);
+		let s = await U((await o.json()).htsget.urls.slice(1), r), c = await this.readBamFeatures(s, [], [], {
+			minv: {
+				dataPosition: 0,
+				blockPosition: 0
+			},
+			maxv: {
+				dataPosition: 0,
+				blockPosition: 0
+			}
+		}), l = [];
+		for (let e = 0, r = c.length; e < r; e++) {
+			let r = c[e];
+			if (r.ref_id === a) {
+				if (r.start >= n) break;
+				r.end >= t && l.push(r);
+			}
+		}
+		return l;
+	}
+	async getHeader(e = {}) {
+		let t = `${this.baseUrl}/${this.trackId}?referenceName=na&class=header`, n = await fetch(t, e);
+		if (!n.ok) throw Error(`HTTP ${n.status} fetching ${t}: ${await n.text()}`);
+		let r = await U((await n.json()).htsget.urls, e), i = new DataView(r.buffer);
+		if (i.getInt32(0, !0) !== 21840194) throw Error("Not a BAM file");
+		let a = i.getInt32(4, !0), o = B(new TextDecoder("utf8").decode(r.subarray(8, 8 + a))), s = [], c = {}, l = o.filter((e) => e.tag === "SQ");
+		for (let [e, t] of l.entries()) {
+			let n = "", r = 0;
+			for (let e of t.data) e.tag === "SN" ? n = e.value : e.tag === "LN" && (r = +e.value);
+			c[n] = e, s[e] = {
+				refName: n,
+				length: r
+			};
+		}
+		return this.chrToIndex = c, this.indexToChr = s, o;
+	}
+};
+//#endregion
+export { T as BAI, H as BamFile, z as BamRecord, M as CSI, W as HtsgetFile };