@fnndsc/argus 0.7.0 → 0.7.2

package/dist/assets/index-BEqlmVJ8.js

@@ -0,0 +1,2456 @@
+const __vite__mapDeps=(i,m=__vite__mapDeps,d=(m.f||(m.f=["./blosc-CrUiACa7.js","./chunk-INHXZS53-D3tQiqtZ.js","./lz4-B_Exjfmr.js","./zstd-u5eweWyS.js"])))=>i.map(i=>d[i]);
+import{g as va}from"./_commonjsHelpers-CE1G-McA.js";import{_ as Mi}from"./index-B1IRr1ii.js";var _t=1e-6,Ae=typeof Float32Array<"u"?Float32Array:Array;function qi(){var t=new Ae(9);return Ae!=Float32Array&&(t[1]=0,t[2]=0,t[3]=0,t[5]=0,t[6]=0,t[7]=0),t[0]=1,t[4]=1,t[8]=1,t}function wa(t,e){return t[0]=e[0],t[1]=e[1],t[2]=e[2],t[3]=e[4],t[4]=e[5],t[5]=e[6],t[6]=e[8],t[7]=e[9],t[8]=e[10],t}function He(t,e,i,r,s,n,a,o,l){var c=new Ae(9);return c[0]=t,c[1]=e,c[2]=i,c[3]=r,c[4]=s,c[5]=n,c[6]=a,c[7]=o,c[8]=l,c}function ya(t,e){var i=e[0],r=e[1],s=e[2],n=e[3],a=e[4],o=e[5],l=e[6],c=e[7],h=e[8],d=h*a-o*c,f=-h*n+o*l,u=c*n-a*l,m=i*d+r*f+s*u;return m?(m=1/m,t[0]=d*m,t[1]=(-h*r+s*c)*m,t[2]=(o*r-s*a)*m,t[3]=f*m,t[4]=(h*i-s*l)*m,t[5]=(-o*i+s*n)*m,t[6]=u*m,t[7]=(-c*i+r*l)*m,t[8]=(a*i-r*n)*m,t):null}function Hs(t,e,i){var r=e[0],s=e[1],n=e[2],a=e[3],o=e[4],l=e[5],c=e[6],h=e[7],d=e[8],f=i[0],u=i[1],m=i[2],p=i[3],g=i[4],x=i[5],A=i[6],y=i[7],v=i[8];return t[0]=f*r+u*a+m*c,t[1]=f*s+u*o+m*h,t[2]=f*n+u*l+m*d,t[3]=p*r+g*a+x*c,t[4]=p*s+g*o+x*h,t[5]=p*n+g*l+x*d,t[6]=A*r+y*a+v*c,t[7]=A*s+y*o+v*h,t[8]=A*n+y*l+v*d,t}function J(){var t=new Ae(16);return Ae!=Float32Array&&(t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[6]=0,t[7]=0,t[8]=0,t[9]=0,t[11]=0,t[12]=0,t[13]=0,t[14]=0),t[0]=1,t[5]=1,t[10]=1,t[15]=1,t}function de(t){var e=new Ae(16);return e[0]=t[0],e[1]=t[1],e[2]=t[2],e[3]=t[3],e[4]=t[4],e[5]=t[5],e[6]=t[6],e[7]=t[7],e[8]=t[8],e[9]=t[9],e[10]=t[10],e[11]=t[11],e[12]=t[12],e[13]=t[13],e[14]=t[14],e[15]=t[15],e}function ba(t,e){return t[0]=e[0],t[1]=e[1],t[2]=e[2],t[3]=e[3],t[4]=e[4],t[5]=e[5],t[6]=e[6],t[7]=e[7],t[8]=e[8],t[9]=e[9],t[10]=e[10],t[11]=e[11],t[12]=e[12],t[13]=e[13],t[14]=e[14],t[15]=e[15],t}function Ee(t,e,i,r,s,n,a,o,l,c,h,d,f,u,m,p){var g=new Ae(16);return g[0]=t,g[1]=e,g[2]=i,g[3]=r,g[4]=s,g[5]=n,g[6]=a,g[7]=o,g[8]=l,g[9]=c,g[10]=h,g[11]=d,g[12]=f,g[13]=u,g[14]=m,g[15]=p,g}function qs(t){return t[0]=1,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=1,t[6]=0,t[7]=0,t[8]=0,t[9]=0,t[10]=1,t[11]=0,t[12]=0,t[13]=0,t[14]=0,t[15]=1,t}function Te(t,e){if(t===e){var i=e[1],r=e[2],s=e[3],n=e[6],a=e[7],o=e[11];t[1]=e[4],t[2]=e[8],t[3]=e[12],t[4]=i,t[6]=e[9],t[7]=e[13],t[8]=r,t[9]=n,t[11]=e[14],t[12]=s,t[13]=a,t[14]=o}else t[0]=e[0],t[1]=e[4],t[2]=e[8],t[3]=e[12],t[4]=e[1],t[5]=e[5],t[6]=e[9],t[7]=e[13],t[8]=e[2],t[9]=e[6],t[10]=e[10],t[11]=e[14],t[12]=e[3],t[13]=e[7],t[14]=e[11],t[15]=e[15];return t}function Se(t,e){var i=e[0],r=e[1],s=e[2],n=e[3],a=e[4],o=e[5],l=e[6],c=e[7],h=e[8],d=e[9],f=e[10],u=e[11],m=e[12],p=e[13],g=e[14],x=e[15],A=i*o-r*a,y=i*l-s*a,v=i*c-n*a,b=r*l-s*o,w=r*c-n*o,C=s*c-n*l,M=h*p-d*m,T=h*g-f*m,E=h*x-u*m,I=d*g-f*p,S=d*x-u*p,U=f*x-u*g,B=A*U-y*S+v*I+b*E-w*T+C*M;return B?(B=1/B,t[0]=(o*U-l*S+c*I)*B,t[1]=(s*S-r*U-n*I)*B,t[2]=(p*C-g*w+x*b)*B,t[3]=(f*w-d*C-u*b)*B,t[4]=(l*E-a*U-c*T)*B,t[5]=(i*U-s*E+n*T)*B,t[6]=(g*v-m*C-x*y)*B,t[7]=(h*C-f*v+u*y)*B,t[8]=(a*S-o*E+c*M)*B,t[9]=(r*E-i*S-n*M)*B,t[10]=(m*w-p*v+x*A)*B,t[11]=(d*v-h*w-u*A)*B,t[12]=(o*T-a*I-l*M)*B,t[13]=(i*I-r*T+s*M)*B,t[14]=(p*y-m*b-g*A)*B,t[15]=(h*b-d*y+f*A)*B,t):null}function Ye(t,e,i){var r=e[0],s=e[1],n=e[2],a=e[3],o=e[4],l=e[5],c=e[6],h=e[7],d=e[8],f=e[9],u=e[10],m=e[11],p=e[12],g=e[13],x=e[14],A=e[15],y=i[0],v=i[1],b=i[2],w=i[3];return t[0]=y*r+v*o+b*d+w*p,t[1]=y*s+v*l+b*f+w*g,t[2]=y*n+v*c+b*u+w*x,t[3]=y*a+v*h+b*m+w*A,y=i[4],v=i[5],b=i[6],w=i[7],t[4]=y*r+v*o+b*d+w*p,t[5]=y*s+v*l+b*f+w*g,t[6]=y*n+v*c+b*u+w*x,t[7]=y*a+v*h+b*m+w*A,y=i[8],v=i[9],b=i[10],w=i[11],t[8]=y*r+v*o+b*d+w*p,t[9]=y*s+v*l+b*f+w*g,t[10]=y*n+v*c+b*u+w*x,t[11]=y*a+v*h+b*m+w*A,y=i[12],v=i[13],b=i[14],w=i[15],t[12]=y*r+v*o+b*d+w*p,t[13]=y*s+v*l+b*f+w*g,t[14]=y*n+v*c+b*u+w*x,t[15]=y*a+v*h+b*m+w*A,t}function tt(t,e,i){var r=i[0],s=i[1],n=i[2],a,o,l,c,h,d,f,u,m,p,g,x;return e===t?(t[12]=e[0]*r+e[4]*s+e[8]*n+e[12],t[13]=e[1]*r+e[5]*s+e[9]*n+e[13],t[14]=e[2]*r+e[6]*s+e[10]*n+e[14],t[15]=e[3]*r+e[7]*s+e[11]*n+e[15]):(a=e[0],o=e[1],l=e[2],c=e[3],h=e[4],d=e[5],f=e[6],u=e[7],m=e[8],p=e[9],g=e[10],x=e[11],t[0]=a,t[1]=o,t[2]=l,t[3]=c,t[4]=h,t[5]=d,t[6]=f,t[7]=u,t[8]=m,t[9]=p,t[10]=g,t[11]=x,t[12]=a*r+h*s+m*n+e[12],t[13]=o*r+d*s+p*n+e[13],t[14]=l*r+f*s+g*n+e[14],t[15]=c*r+u*s+x*n+e[15]),t}function fr(t,e,i){var r=i[0],s=i[1],n=i[2];return t[0]=e[0]*r,t[1]=e[1]*r,t[2]=e[2]*r,t[3]=e[3]*r,t[4]=e[4]*s,t[5]=e[5]*s,t[6]=e[6]*s,t[7]=e[7]*s,t[8]=e[8]*n,t[9]=e[9]*n,t[10]=e[10]*n,t[11]=e[11]*n,t[12]=e[12],t[13]=e[13],t[14]=e[14],t[15]=e[15],t}function Ut(t,e,i){var r=Math.sin(i),s=Math.cos(i),n=e[4],a=e[5],o=e[6],l=e[7],c=e[8],h=e[9],d=e[10],f=e[11];return e!==t&&(t[0]=e[0],t[1]=e[1],t[2]=e[2],t[3]=e[3],t[12]=e[12],t[13]=e[13],t[14]=e[14],t[15]=e[15]),t[4]=n*s+c*r,t[5]=a*s+h*r,t[6]=o*s+d*r,t[7]=l*s+f*r,t[8]=c*s-n*r,t[9]=h*s-a*r,t[10]=d*s-o*r,t[11]=f*s-l*r,t}function Ca(t,e,i){var r=Math.sin(i),s=Math.cos(i),n=e[0],a=e[1],o=e[2],l=e[3],c=e[8],h=e[9],d=e[10],f=e[11];return e!==t&&(t[4]=e[4],t[5]=e[5],t[6]=e[6],t[7]=e[7],t[12]=e[12],t[13]=e[13],t[14]=e[14],t[15]=e[15]),t[0]=n*s-c*r,t[1]=a*s-h*r,t[2]=o*s-d*r,t[3]=l*s-f*r,t[8]=n*r+c*s,t[9]=a*r+h*s,t[10]=o*r+d*s,t[11]=l*r+f*s,t}function Rt(t,e,i){var r=Math.sin(i),s=Math.cos(i),n=e[0],a=e[1],o=e[2],l=e[3],c=e[4],h=e[5],d=e[6],f=e[7];return e!==t&&(t[8]=e[8],t[9]=e[9],t[10]=e[10],t[11]=e[11],t[12]=e[12],t[13]=e[13],t[14]=e[14],t[15]=e[15]),t[0]=n*s+c*r,t[1]=a*s+h*r,t[2]=o*s+d*r,t[3]=l*s+f*r,t[4]=c*s-n*r,t[5]=h*s-a*r,t[6]=d*s-o*r,t[7]=f*s-l*r,t}function Ma(t,e,i){var r=i[0],s=i[1],n=i[2],a=Math.sqrt(r*r+s*s+n*n),o,l,c;return a<_t?null:(a=1/a,r*=a,s*=a,n*=a,o=Math.sin(e),l=Math.cos(e),c=1-l,t[0]=r*r*c+l,t[1]=s*r*c+n*o,t[2]=n*r*c-s*o,t[3]=0,t[4]=r*s*c-n*o,t[5]=s*s*c+l,t[6]=n*s*c+r*o,t[7]=0,t[8]=r*n*c+s*o,t[9]=s*n*c-r*o,t[10]=n*n*c+l,t[11]=0,t[12]=0,t[13]=0,t[14]=0,t[15]=1,t)}function Da(t,e,i,r,s,n,a){var o=1/(e-i),l=1/(r-s),c=1/(n-a);return t[0]=-2*o,t[1]=0,t[2]=0,t[3]=0,t[4]=0,t[5]=-2*l,t[6]=0,t[7]=0,t[8]=0,t[9]=0,t[10]=2*c,t[11]=0,t[12]=(e+i)*o,t[13]=(s+r)*l,t[14]=(a+n)*c,t[15]=1,t}var hi=Da;function Ta(t,e,i){return t[0]=e[0]*i,t[1]=e[1]*i,t[2]=e[2]*i,t[3]=e[3]*i,t[4]=e[4]*i,t[5]=e[5]*i,t[6]=e[6]*i,t[7]=e[7]*i,t[8]=e[8]*i,t[9]=e[9]*i,t[10]=e[10]*i,t[11]=e[11]*i,t[12]=e[12]*i,t[13]=e[13]*i,t[14]=e[14]*i,t[15]=e[15]*i,t}var Qs=Ye;function se(){var t=new Ae(3);return Ae!=Float32Array&&(t[0]=0,t[1]=0,t[2]=0),t}function Ve(t){var e=new Ae(3);return e[0]=t[0],e[1]=t[1],e[2]=t[2],e}function Qe(t){var e=t[0],i=t[1],r=t[2];return Math.sqrt(e*e+i*i+r*r)}function k(t,e,i){var r=new Ae(3);return r[0]=t,r[1]=e,r[2]=i,r}function Hr(t,e){return t[0]=e[0],t[1]=e[1],t[2]=e[2],t}function it(t,e,i){return t[0]=e[0]+i[0],t[1]=e[1]+i[1],t[2]=e[2]+i[2],t}function ne(t,e,i){return t[0]=e[0]-i[0],t[1]=e[1]-i[1],t[2]=e[2]-i[2],t}function ur(t,e,i){return t[0]=Math.min(e[0],i[0]),t[1]=Math.min(e[1],i[1]),t[2]=Math.min(e[2],i[2]),t}function mr(t,e,i){return t[0]=Math.max(e[0],i[0]),t[1]=Math.max(e[1],i[1]),t[2]=Math.max(e[2],i[2]),t}function Sa(t,e,i){return t[0]=e[0]*i,t[1]=e[1]*i,t[2]=e[2]*i,t}function Ea(t,e){var i=e[0]-t[0],r=e[1]-t[1],s=e[2]-t[2];return Math.sqrt(i*i+r*r+s*s)}function Ia(t,e){return t[0]=-e[0],t[1]=-e[1],t[2]=-e[2],t}function Ie(t,e){var i=e[0],r=e[1],s=e[2],n=i*i+r*r+s*s;return n>0&&(n=1/Math.sqrt(n)),t[0]=e[0]*n,t[1]=e[1]*n,t[2]=e[2]*n,t}function Fa(t,e){return t[0]*e[0]+t[1]*e[1]+t[2]*e[2]}function Jt(t,e,i){var r=e[0],s=e[1],n=e[2],a=i[0],o=i[1],l=i[2];return t[0]=s*l-n*o,t[1]=n*a-r*l,t[2]=r*o-s*a,t}function Ba(t,e,i,r){var s=e[0],n=e[1],a=e[2];return t[0]=s+r*(i[0]-s),t[1]=n+r*(i[1]-n),t[2]=a+r*(i[2]-a),t}function qr(t,e,i){var r=e[0],s=e[1],n=e[2];return t[0]=r*i[0]+s*i[3]+n*i[6],t[1]=r*i[1]+s*i[4]+n*i[7],t[2]=r*i[2]+s*i[5]+n*i[8],t}function Di(t,e){var i=t[0],r=t[1],s=t[2],n=e[0],a=e[1],o=e[2],l=Math.sqrt((i*i+r*r+s*s)*(n*n+a*a+o*o)),c=l&&Fa(t,e)/l;return Math.acos(Math.min(Math.max(c,-1),1))}function Ua(t,e){var i=t[0],r=t[1],s=t[2],n=e[0],a=e[1],o=e[2];return Math.abs(i-n)<=_t*Math.max(1,Math.abs(i),Math.abs(n))&&Math.abs(r-a)<=_t*Math.max(1,Math.abs(r),Math.abs(a))&&Math.abs(s-o)<=_t*Math.max(1,Math.abs(s),Math.abs(o))}var Qr=ne,Vt=Qe;(function(){var t=se();return function(e,i,r,s,n,a){var o,l;for(i||(i=3),r||(r=0),s?l=Math.min(s*i+r,e.length):l=e.length,o=r;o<l;o+=i)t[0]=e[o],t[1]=e[o+1],t[2]=e[o+2],n(t,t,a),e[o]=t[0],e[o+1]=t[1],e[o+2]=t[2];return e}})();function Xe(){var t=new Ae(4);return Ae!=Float32Array&&(t[0]=0,t[1]=0,t[2]=0,t[3]=0),t}function ze(t){var e=new Ae(4);return 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r=e&&e.dictionary&&e.dictionary.subarray(-32768);this.s={i:0,b:r?r.length:0},this.o=new ge(32768),this.p=new ge(0),r&&this.o.set(r)}return t.prototype.e=function(e){if(this.ondata||ye(5),this.d&&ye(4),!this.p.length)this.p=e;else if(e.length){var i=new ge(this.p.length+e.length);i.set(this.p),i.set(e,this.p.length),this.p=i}},t.prototype.c=function(e){this.s.i=+(this.d=e||!1);var i=this.s.b,r=Ai(this.p,this.s,this.o);this.ondata(ei(r,i,this.s.b),this.d),this.o=ei(r,this.s.b-32768),this.s.b=this.o.length,this.p=ei(this.p,this.s.p/8|0),this.s.p&=7},t.prototype.push=function(e,i){this.e(e),this.c(i)},t})();function Ja(t,e){return Ai(t,{i:2},e,e)}var $a=(function(){function t(e,i){this.v=1,this.r=0,Xt.call(this,e,i)}return t.prototype.push=function(e,i){if(Xt.prototype.e.call(this,e),this.r+=e.length,this.v){var r=this.p.subarray(this.v-1),s=r.length>3?rn(r):4;if(s>r.length){if(!i)return}else 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r.setInt32(0,this.esize,this.littleEndian),r.setInt32(4,this.ecode,this.littleEndian),e.buffer}}class O{static crcTable=null;static GUNZIP_MAGIC_COOKIE1=31;static GUNZIP_MAGIC_COOKIE2=139;static getStringAt(e,i,r){var s="",n,a;for(n=i;n<r;n+=1)a=e.getUint8(n),a!==0&&(s+=String.fromCharCode(a));return s}static getByteAt=function(e,i){return e.getUint8(i)};static getShortAt=function(e,i,r){return e.getInt16(i,r)};static getIntAt(e,i,r){return e.getInt32(i,r)}static getFloatAt(e,i,r){return e.getFloat32(i,r)}static getDoubleAt(e,i,r){return e.getFloat64(i,r)}static getInt64At(e,i,r){const s=e.getUint32(i,r),n=e.getInt32(i+4,r);let a;return r?a=n*2**32+s:a=s*2**32+n,n<0&&(a+=-1*2**32*2**32),a}static getUint64At(e,i,r){const s=e.getUint32(i+(r?0:4),r),n=e.getUint32(i+(r?4:0),r);return r?n*2**32+s:s*2**32+n}static getExtensionsAt(e,i,r,s){let n=[],a=i;for(;a<s;){let o=r,l=O.getIntAt(e,a,r);if(!l)break;if(l+a>s&&(o=!o,l=O.getIntAt(e,a,o),l+a>s))throw new Error("This does not appear to be a 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G{littleEndian=!1;dim_info=0;dims=[];intent_p1=0;intent_p2=0;intent_p3=0;intent_code=0;datatypeCode=0;numBitsPerVoxel=0;slice_start=0;slice_end=0;slice_code=0;pixDims=[];vox_offset=0;scl_slope=1;scl_inter=0;xyzt_units=0;cal_max=0;cal_min=0;slice_duration=0;toffset=0;description="";aux_file="";intent_name="";qform_code=0;sform_code=0;quatern_a=0;quatern_b=0;quatern_c=0;quatern_d=0;qoffset_x=0;qoffset_y=0;qoffset_z=0;affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]];qfac=1;quatern_R;magic="0";isHDR=!1;extensionFlag=[0,0,0,0];extensionSize=0;extensionCode=0;extensions=[];static TYPE_NONE=0;static TYPE_BINARY=1;static TYPE_UINT8=2;static TYPE_INT16=4;static TYPE_INT32=8;static TYPE_FLOAT32=16;static TYPE_COMPLEX64=32;static TYPE_FLOAT64=64;static TYPE_RGB24=128;static TYPE_INT8=256;static TYPE_UINT16=512;static TYPE_UINT32=768;static TYPE_INT64=1024;static TYPE_UINT64=1280;static TYPE_FLOAT128=1536;static TYPE_COMPLEX128=1792;static TYPE_COMPLEX256=2048;static XFORM_UNKNOWN=0;static XFORM_SCANNER_ANAT=1;static XFORM_ALIGNED_ANAT=2;static XFORM_TALAIRACH=3;static XFORM_MNI_152=4;static SPATIAL_UNITS_MASK=7;static TEMPORAL_UNITS_MASK=56;static UNITS_UNKNOWN=0;static UNITS_METER=1;static UNITS_MM=2;static UNITS_MICRON=3;static UNITS_SEC=8;static UNITS_MSEC=16;static UNITS_USEC=24;static UNITS_HZ=32;static UNITS_PPM=40;static UNITS_RADS=48;static MAGIC_COOKIE=348;static STANDARD_HEADER_SIZE=348;static MAGIC_NUMBER_LOCATION=344;static MAGIC_NUMBER=[110,43,49];static MAGIC_NUMBER2=[110,105,49];static EXTENSION_HEADER_SIZE=8;readHeader(e){var i=new DataView(e),r=O.getIntAt(i,0,this.littleEndian),s,n,a,o;if(r!==G.MAGIC_COOKIE&&(this.littleEndian=!0,r=O.getIntAt(i,0,this.littleEndian)),r!==G.MAGIC_COOKIE)throw new Error("This does not appear to be a NIFTI file!");for(this.dim_info=O.getByteAt(i,39),s=0;s<8;s+=1)o=40+s*2,this.dims[s]=O.getShortAt(i,o,this.littleEndian);for(this.intent_p1=O.getFloatAt(i,56,this.littleEndian),this.intent_p2=O.getFloatAt(i,60,this.littleEndian),this.intent_p3=O.getFloatAt(i,64,this.littleEndian),this.intent_code=O.getShortAt(i,68,this.littleEndian),this.datatypeCode=O.getShortAt(i,70,this.littleEndian),this.numBitsPerVoxel=O.getShortAt(i,72,this.littleEndian),this.slice_start=O.getShortAt(i,74,this.littleEndian),s=0;s<8;s+=1)o=76+s*4,this.pixDims[s]=O.getFloatAt(i,o,this.littleEndian);if(this.vox_offset=O.getFloatAt(i,108,this.littleEndian),this.scl_slope=O.getFloatAt(i,112,this.littleEndian),this.scl_inter=O.getFloatAt(i,116,this.littleEndian),this.slice_end=O.getShortAt(i,120,this.littleEndian),this.slice_code=O.getByteAt(i,122),this.xyzt_units=O.getByteAt(i,123),this.cal_max=O.getFloatAt(i,124,this.littleEndian),this.cal_min=O.getFloatAt(i,128,this.littleEndian),this.slice_duration=O.getFloatAt(i,132,this.littleEndian),this.toffset=O.getFloatAt(i,136,this.littleEndian),this.description=O.getStringAt(i,148,228),this.aux_file=O.getStringAt(i,228,252),this.qform_code=O.getShortAt(i,252,this.littleEndian),this.sform_code=O.getShortAt(i,254,this.littleEndian),this.quatern_b=O.getFloatAt(i,256,this.littleEndian),this.quatern_c=O.getFloatAt(i,260,this.littleEndian),this.quatern_d=O.getFloatAt(i,264,this.littleEndian),this.quatern_a=Math.sqrt(1-(Math.pow(this.quatern_b,2)+Math.pow(this.quatern_c,2)+Math.pow(this.quatern_d,2))),this.qoffset_x=O.getFloatAt(i,268,this.littleEndian),this.qoffset_y=O.getFloatAt(i,272,this.littleEndian),this.qoffset_z=O.getFloatAt(i,276,this.littleEndian),this.qform_code<1&&this.sform_code<1&&(this.affine[0][0]=this.pixDims[1],this.affine[1][1]=this.pixDims[2],this.affine[2][2]=this.pixDims[3]),this.qform_code>0&&this.sform_code<this.qform_code){const l=this.quatern_a,c=this.quatern_b,h=this.quatern_c,d=this.quatern_d;for(this.qfac=this.pixDims[0]===0?1:this.pixDims[0],this.quatern_R=[[l*l+c*c-h*h-d*d,2*c*h-2*l*d,2*c*d+2*l*h],[2*c*h+2*l*d,l*l+h*h-c*c-d*d,2*h*d-2*l*c],[2*c*d-2*l*h,2*h*d+2*l*c,l*l+d*d-h*h-c*c]],n=0;n<3;n+=1)for(a=0;a<3;a+=1)this.affine[n][a]=this.quatern_R[n][a]*this.pixDims[a+1],a===2&&(this.affine[n][a]*=this.qfac);this.affine[0][3]=this.qoffset_x,this.affine[1][3]=this.qoffset_y,this.affine[2][3]=this.qoffset_z}else if(this.sform_code>0)for(n=0;n<3;n+=1)for(a=0;a<4;a+=1)o=280+(n*4+a)*4,this.affine[n][a]=O.getFloatAt(i,o,this.littleEndian);if(this.affine[3][0]=0,this.affine[3][1]=0,this.affine[3][2]=0,this.affine[3][3]=1,this.intent_name=O.getStringAt(i,328,344),this.magic=O.getStringAt(i,344,348),this.isHDR=this.magic===String.fromCharCode.apply(null,G.MAGIC_NUMBER2),i.byteLength>G.MAGIC_COOKIE){this.extensionFlag[0]=O.getByteAt(i,348),this.extensionFlag[1]=O.getByteAt(i,349),this.extensionFlag[2]=O.getByteAt(i,350),this.extensionFlag[3]=O.getByteAt(i,351);let l=!0;!this.isHDR&&this.vox_offset<=352&&(l=!1),i.byteLength<=368&&(l=!1),l&&this.extensionFlag[0]&&(this.extensions=O.getExtensionsAt(i,this.getExtensionLocation(),this.littleEndian,this.vox_offset),this.extensionSize=this.extensions[0].esize,this.extensionCode=this.extensions[0].ecode)}}toFormattedString(){var e=O.formatNumber,i="";return i+="Dim Info = "+this.dim_info+`
+`,i+="Image Dimensions (1-8): "+this.dims[0]+", "+this.dims[1]+", "+this.dims[2]+", "+this.dims[3]+", "+this.dims[4]+", "+this.dims[5]+", "+this.dims[6]+", "+this.dims[7]+`
+`,i+="Intent Parameters (1-3): "+this.intent_p1+", "+this.intent_p2+", "+this.intent_p3+`
+`,i+="Intent Code = "+this.intent_code+`
+`,i+="Datatype = "+this.datatypeCode+" ("+this.getDatatypeCodeString(this.datatypeCode)+`)
+`,i+="Bits Per Voxel = "+this.numBitsPerVoxel+`
+`,i+="Slice Start = "+this.slice_start+`
+`,i+="Voxel Dimensions (1-8): "+e(this.pixDims[0])+", "+e(this.pixDims[1])+", "+e(this.pixDims[2])+", "+e(this.pixDims[3])+", "+e(this.pixDims[4])+", "+e(this.pixDims[5])+", "+e(this.pixDims[6])+", "+e(this.pixDims[7])+`
+`,i+="Image Offset = "+this.vox_offset+`
+`,i+="Data Scale:  Slope = "+e(this.scl_slope)+"  Intercept = "+e(this.scl_inter)+`
+`,i+="Slice End = "+this.slice_end+`
+`,i+="Slice Code = "+this.slice_code+`
+`,i+="Units Code = "+this.xyzt_units+" ("+this.getUnitsCodeString(G.SPATIAL_UNITS_MASK&this.xyzt_units)+", "+this.getUnitsCodeString(G.TEMPORAL_UNITS_MASK&this.xyzt_units)+`)
+`,i+="Display Range:  Max = "+e(this.cal_max)+"  Min = "+e(this.cal_min)+`
+`,i+="Slice Duration = "+this.slice_duration+`
+`,i+="Time Axis Shift = "+this.toffset+`
+`,i+='Description: "'+this.description+`"
+`,i+='Auxiliary File: "'+this.aux_file+`"
+`,i+="Q-Form Code = "+this.qform_code+" ("+this.getTransformCodeString(this.qform_code)+`)
+`,i+="S-Form Code = "+this.sform_code+" ("+this.getTransformCodeString(this.sform_code)+`)
+`,i+="Quaternion Parameters:  b = "+e(this.quatern_b)+"  c = "+e(this.quatern_c)+"  d = "+e(this.quatern_d)+`
+`,i+="Quaternion Offsets:  x = "+this.qoffset_x+"  y = "+this.qoffset_y+"  z = "+this.qoffset_z+`
+`,i+="S-Form Parameters X: "+e(this.affine[0][0])+", "+e(this.affine[0][1])+", "+e(this.affine[0][2])+", "+e(this.affine[0][3])+`
+`,i+="S-Form Parameters Y: "+e(this.affine[1][0])+", "+e(this.affine[1][1])+", "+e(this.affine[1][2])+", "+e(this.affine[1][3])+`
+`,i+="S-Form Parameters Z: "+e(this.affine[2][0])+", "+e(this.affine[2][1])+", "+e(this.affine[2][2])+", "+e(this.affine[2][3])+`
+`,i+='Intent Name: "'+this.intent_name+`"
+`,this.extensionFlag[0]&&(i+="Extension: Size = "+this.extensionSize+"  Code = "+this.extensionCode+`
+`),i}getDatatypeCodeString=function(e){return e===G.TYPE_UINT8?"1-Byte Unsigned Integer":e===G.TYPE_INT16?"2-Byte Signed Integer":e===G.TYPE_INT32?"4-Byte Signed Integer":e===G.TYPE_FLOAT32?"4-Byte Float":e===G.TYPE_FLOAT64?"8-Byte Float":e===G.TYPE_RGB24?"RGB":e===G.TYPE_INT8?"1-Byte Signed Integer":e===G.TYPE_UINT16?"2-Byte Unsigned Integer":e===G.TYPE_UINT32?"4-Byte Unsigned Integer":e===G.TYPE_INT64?"8-Byte Signed Integer":e===G.TYPE_UINT64?"8-Byte Unsigned Integer":"Unknown"};getTransformCodeString=function(e){return e===G.XFORM_SCANNER_ANAT?"Scanner":e===G.XFORM_ALIGNED_ANAT?"Aligned":e===G.XFORM_TALAIRACH?"Talairach":e===G.XFORM_MNI_152?"MNI":"Unknown"};getUnitsCodeString=function(e){return e===G.UNITS_METER?"Meters":e===G.UNITS_MM?"Millimeters":e===G.UNITS_MICRON?"Microns":e===G.UNITS_SEC?"Seconds":e===G.UNITS_MSEC?"Milliseconds":e===G.UNITS_USEC?"Microseconds":e===G.UNITS_HZ?"Hz":e===G.UNITS_PPM?"PPM":e===G.UNITS_RADS?"Rads":"Unknown"};getQformMat(){return this.convertNiftiQFormToNiftiSForm(this.quatern_b,this.quatern_c,this.quatern_d,this.qoffset_x,this.qoffset_y,this.qoffset_z,this.pixDims[1],this.pixDims[2],this.pixDims[3],this.pixDims[0])}convertNiftiQFormToNiftiSForm(e,i,r,s,n,a,o,l,c,h){var d=[[0,0,0,0],[0,0,0,0],[0,0,0,0],[0,0,0,0]],f,u=e,m=i,p=r,g,x,A;return d[3][0]=d[3][1]=d[3][2]=0,d[3][3]=1,f=1-(u*u+m*m+p*p),f<1e-7?(f=1/Math.sqrt(u*u+m*m+p*p),u*=f,m*=f,p*=f,f=0):f=Math.sqrt(f),g=o>0?o:1,x=l>0?l:1,A=c>0?c:1,h<0&&(A=-A),d[0][0]=(f*f+u*u-m*m-p*p)*g,d[0][1]=2*(u*m-f*p)*x,d[0][2]=2*(u*p+f*m)*A,d[1][0]=2*(u*m+f*p)*g,d[1][1]=(f*f+m*m-u*u-p*p)*x,d[1][2]=2*(m*p-f*u)*A,d[2][0]=2*(u*p-f*m)*g,d[2][1]=2*(m*p+f*u)*x,d[2][2]=(f*f+p*p-m*m-u*u)*A,d[0][3]=s,d[1][3]=n,d[2][3]=a,d}convertNiftiSFormToNEMA(e){var i,r,s,n,a,o,l,c,h,d,f,u,m,p,g,x,A,y,v,b,w,C,M,T,E,I,S,U,B,V,R,P,L,N;if(g=0,S=[[0,0,0],[0,0,0],[0,0,0]],U=[[0,0,0],[0,0,0],[0,0,0]],i=e[0][0],r=e[0][1],s=e[0][2],n=e[1][0],a=e[1][1],o=e[1][2],l=e[2][0],c=e[2][1],h=e[2][2],d=Math.sqrt(i*i+n*n+l*l),d===0||(i/=d,n/=d,l/=d,d=Math.sqrt(r*r+a*a+c*c),d===0))return null;if(r/=d,a/=d,c/=d,d=i*r+n*a+l*c,Math.abs(d)>1e-4){if(r-=d*i,a-=d*n,c-=d*l,d=Math.sqrt(r*r+a*a+c*c),d===0)return null;r/=d,a/=d,c/=d}if(d=Math.sqrt(s*s+o*o+h*h),d===0?(s=n*c-l*a,o=l*r-c*i,h=i*a-n*r):(s/=d,o/=d,h/=d),d=i*s+n*o+l*h,Math.abs(d)>1e-4){if(s-=d*i,o-=d*n,h-=d*l,d=Math.sqrt(s*s+o*o+h*h),d===0)return null;s/=d,o/=d,h/=d}if(d=r*s+a*o+c*h,Math.abs(d)>1e-4){if(s-=d*r,o-=d*a,h-=d*c,d=Math.sqrt(s*s+o*o+h*h),d===0)return null;s/=d,o/=d,h/=d}if(S[0][0]=i,S[0][1]=r,S[0][2]=s,S[1][0]=n,S[1][1]=a,S[1][2]=o,S[2][0]=l,S[2][1]=c,S[2][2]=h,f=this.nifti_mat33_determ(S),f===0)return null;for(I=-666,v=C=M=T=1,b=2,w=3,m=1;m<=3;m+=1)for(p=1;p<=3;p+=1)if(m!==p){for(g=1;g<=3;g+=1)if(!(m===g||p===g))for(U[0][0]=U[0][1]=U[0][2]=U[1][0]=U[1][1]=U[1][2]=U[2][0]=U[2][1]=U[2][2]=0,x=-1;x<=1;x+=2)for(A=-1;A<=1;A+=2)for(y=-1;y<=1;y+=2)U[0][m-1]=x,U[1][p-1]=A,U[2][g-1]=y,u=this.nifti_mat33_determ(U),u*f>0&&(E=this.nifti_mat33_mul(U,S),d=E[0][0]+E[1][1]+E[2][2],d>I&&(I=d,v=m,b=p,w=g,C=x,M=A,T=y))}switch(B=V=R=P=L=N="",v*C){case 1:B="X",P="+";break;case-1:B="X",P="-";break;case 2:B="Y",P="+";break;case-2:B="Y",P="-";break;case 3:B="Z",P="+";break;case-3:B="Z",P="-";break}switch(b*M){case 1:V="X",L="+";break;case-1:V="X",L="-";break;case 2:V="Y",L="+";break;case-2:V="Y",L="-";break;case 3:V="Z",L="+";break;case-3:V="Z",L="-";break}switch(w*T){case 1:R="X",N="+";break;case-1:R="X",N="-";break;case 2:R="Y",N="+";break;case-2:R="Y",N="-";break;case 3:R="Z",N="+";break;case-3:R="Z",N="-";break}return B+V+R+P+L+N}nifti_mat33_mul=function(e,i){var r=[[0,0,0],[0,0,0],[0,0,0]],s,n;for(s=0;s<3;s+=1)for(n=0;n<3;n+=1)r[s][n]=e[s][0]*i[0][n]+e[s][1]*i[1][n]+e[s][2]*i[2][n];return r};nifti_mat33_determ=function(e){var i,r,s,n,a,o,l,c,h;return i=e[0][0],r=e[0][1],s=e[0][2],n=e[1][0],a=e[1][1],o=e[1][2],l=e[2][0],c=e[2][1],h=e[2][2],i*a*h-i*c*o-n*r*h+n*c*s+l*r*o-l*a*s};getExtensionLocation(){return G.MAGIC_COOKIE+4}getExtensionSize(e){return O.getIntAt(e,this.getExtensionLocation(),this.littleEndian)}getExtensionCode(e){return O.getIntAt(e,this.getExtensionLocation()+4,this.littleEndian)}addExtension(e,i=-1){i==-1?this.extensions.push(e):this.extensions.splice(i,0,e),this.vox_offset+=e.esize}removeExtension(e){let i=this.extensions[e];i&&(this.vox_offset-=i.esize),this.extensions.splice(e,1)}toArrayBuffer(e=!1){let s=352;if(e)for(let l of this.extensions)s+=l.esize;let n=new Uint8Array(s),a=new DataView(n.buffer);a.setInt32(0,348,this.littleEndian),a.setUint8(39,this.dim_info);for(let l=0;l<8;l++)a.setUint16(40+2*l,this.dims[l],this.littleEndian);a.setFloat32(56,this.intent_p1,this.littleEndian),a.setFloat32(60,this.intent_p2,this.littleEndian),a.setFloat32(64,this.intent_p3,this.littleEndian),a.setInt16(68,this.intent_code,this.littleEndian),a.setInt16(70,this.datatypeCode,this.littleEndian),a.setInt16(72,this.numBitsPerVoxel,this.littleEndian),a.setInt16(74,this.slice_start,this.littleEndian);for(let l=0;l<8;l++)a.setFloat32(76+4*l,this.pixDims[l],this.littleEndian);a.setFloat32(108,this.vox_offset,this.littleEndian),a.setFloat32(112,this.scl_slope,this.littleEndian),a.setFloat32(116,this.scl_inter,this.littleEndian),a.setInt16(120,this.slice_end,this.littleEndian),a.setUint8(122,this.slice_code),a.setUint8(123,this.xyzt_units),a.setFloat32(124,this.cal_max,this.littleEndian),a.setFloat32(128,this.cal_min,this.littleEndian),a.setFloat32(132,this.slice_duration,this.littleEndian),a.setFloat32(136,this.toffset,this.littleEndian),n.set(new TextEncoder().encode(this.description),148),n.set(new TextEncoder().encode(this.aux_file),228),a.setInt16(252,this.qform_code,this.littleEndian),a.setInt16(254,this.sform_code,this.littleEndian),a.setFloat32(256,this.quatern_b,this.littleEndian),a.setFloat32(260,this.quatern_c,this.littleEndian),a.setFloat32(264,this.quatern_d,this.littleEndian),a.setFloat32(268,this.qoffset_x,this.littleEndian),a.setFloat32(272,this.qoffset_y,this.littleEndian),a.setFloat32(276,this.qoffset_z,this.littleEndian);const o=this.affine.flat();for(let l=0;l<12;l++)a.setFloat32(280+4*l,o[l],this.littleEndian);if(n.set(new TextEncoder().encode(this.intent_name),328),n.set(new TextEncoder().encode(this.magic),344),e){n.set(Uint8Array.from([1,0,0,0]),348);let l=this.getExtensionLocation();for(const c of this.extensions)a.setInt32(l,c.esize,c.littleEndian),a.setInt32(l+4,c.ecode,c.littleEndian),n.set(new Uint8Array(c.edata),l+8),l+=c.esize}else n.set(new Uint8Array(4).fill(0),348);return n.buffer}}class xe{littleEndian=!1;dim_info=0;dims=[];intent_p1=0;intent_p2=0;intent_p3=0;intent_code=0;datatypeCode=0;numBitsPerVoxel=0;slice_start=0;slice_end=0;slice_code=0;pixDims=[];vox_offset=0;scl_slope=1;scl_inter=0;xyzt_units=0;cal_max=0;cal_min=0;slice_duration=0;toffset=0;description="";aux_file="";intent_name="";qform_code=0;sform_code=0;quatern_b=0;quatern_c=0;quatern_d=0;qoffset_x=0;qoffset_y=0;qoffset_z=0;affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]];magic="0";extensionFlag=[0,0,0,0];extensions=[];extensionSize=0;extensionCode=0;static MAGIC_COOKIE=540;static MAGIC_NUMBER_LOCATION=4;static MAGIC_NUMBER=[110,43,50,0,13,10,26,10];static MAGIC_NUMBER2=[110,105,50,0,13,10,26,10];readHeader(e){var i=new DataView(e),r=O.getIntAt(i,0,this.littleEndian),s,n,a,o;if(r!==xe.MAGIC_COOKIE&&(this.littleEndian=!0,r=O.getIntAt(i,0,this.littleEndian)),r!==xe.MAGIC_COOKIE)throw new Error("This does not appear to be a NIFTI file!");for(this.magic=O.getStringAt(i,4,12),this.datatypeCode=O.getShortAt(i,12,this.littleEndian),this.numBitsPerVoxel=O.getShortAt(i,14,this.littleEndian),s=0;s<8;s+=1)o=16+s*8,this.dims[s]=O.getInt64At(i,o,this.littleEndian);for(this.intent_p1=O.getDoubleAt(i,80,this.littleEndian),this.intent_p2=O.getDoubleAt(i,88,this.littleEndian),this.intent_p3=O.getDoubleAt(i,96,this.littleEndian),s=0;s<8;s+=1)o=104+s*8,this.pixDims[s]=O.getDoubleAt(i,o,this.littleEndian);for(this.vox_offset=O.getInt64At(i,168,this.littleEndian),this.scl_slope=O.getDoubleAt(i,176,this.littleEndian),this.scl_inter=O.getDoubleAt(i,184,this.littleEndian),this.cal_max=O.getDoubleAt(i,192,this.littleEndian),this.cal_min=O.getDoubleAt(i,200,this.littleEndian),this.slice_duration=O.getDoubleAt(i,208,this.littleEndian),this.toffset=O.getDoubleAt(i,216,this.littleEndian),this.slice_start=O.getInt64At(i,224,this.littleEndian),this.slice_end=O.getInt64At(i,232,this.littleEndian),this.description=O.getStringAt(i,240,320),this.aux_file=O.getStringAt(i,320,344),this.qform_code=O.getIntAt(i,344,this.littleEndian),this.sform_code=O.getIntAt(i,348,this.littleEndian),this.quatern_b=O.getDoubleAt(i,352,this.littleEndian),this.quatern_c=O.getDoubleAt(i,360,this.littleEndian),this.quatern_d=O.getDoubleAt(i,368,this.littleEndian),this.qoffset_x=O.getDoubleAt(i,376,this.littleEndian),this.qoffset_y=O.getDoubleAt(i,384,this.littleEndian),this.qoffset_z=O.getDoubleAt(i,392,this.littleEndian),n=0;n<3;n+=1)for(a=0;a<4;a+=1)o=400+(n*4+a)*8,this.affine[n][a]=O.getDoubleAt(i,o,this.littleEndian);this.affine[3][0]=0,this.affine[3][1]=0,this.affine[3][2]=0,this.affine[3][3]=1,this.slice_code=O.getIntAt(i,496,this.littleEndian),this.xyzt_units=O.getIntAt(i,500,this.littleEndian),this.intent_code=O.getIntAt(i,504,this.littleEndian),this.intent_name=O.getStringAt(i,508,524),this.dim_info=O.getByteAt(i,524),i.byteLength>xe.MAGIC_COOKIE&&(this.extensionFlag[0]=O.getByteAt(i,540),this.extensionFlag[1]=O.getByteAt(i,541),this.extensionFlag[2]=O.getByteAt(i,542),this.extensionFlag[3]=O.getByteAt(i,543),this.extensionFlag[0]&&(this.extensions=O.getExtensionsAt(i,this.getExtensionLocation(),this.littleEndian,this.vox_offset),this.extensionSize=this.extensions[0].esize,this.extensionCode=this.extensions[0].ecode))}toFormattedString(){var e=O.formatNumber,i="";return i+="Datatype = "+ +this.datatypeCode+" ("+this.getDatatypeCodeString(this.datatypeCode)+`)
+`,i+="Bits Per Voxel =  = "+this.numBitsPerVoxel+`
+`,i+="Image Dimensions (1-8): "+this.dims[0]+", "+this.dims[1]+", "+this.dims[2]+", "+this.dims[3]+", "+this.dims[4]+", "+this.dims[5]+", "+this.dims[6]+", "+this.dims[7]+`
+`,i+="Intent Parameters (1-3): "+this.intent_p1+", "+this.intent_p2+", "+this.intent_p3+`
+`,i+="Voxel Dimensions (1-8): "+e(this.pixDims[0])+", "+e(this.pixDims[1])+", "+e(this.pixDims[2])+", "+e(this.pixDims[3])+", "+e(this.pixDims[4])+", "+e(this.pixDims[5])+", "+e(this.pixDims[6])+", "+e(this.pixDims[7])+`
+`,i+="Image Offset = "+this.vox_offset+`
+`,i+="Data Scale:  Slope = "+e(this.scl_slope)+"  Intercept = "+e(this.scl_inter)+`
+`,i+="Display Range:  Max = "+e(this.cal_max)+"  Min = "+e(this.cal_min)+`
+`,i+="Slice Duration = "+this.slice_duration+`
+`,i+="Time Axis Shift = "+this.toffset+`
+`,i+="Slice Start = "+this.slice_start+`
+`,i+="Slice End = "+this.slice_end+`
+`,i+='Description: "'+this.description+`"
+`,i+='Auxiliary File: "'+this.aux_file+`"
+`,i+="Q-Form Code = "+this.qform_code+" ("+this.getTransformCodeString(this.qform_code)+`)
+`,i+="S-Form Code = "+this.sform_code+" ("+this.getTransformCodeString(this.sform_code)+`)
+`,i+="Quaternion Parameters:  b = "+e(this.quatern_b)+"  c = "+e(this.quatern_c)+"  d = "+e(this.quatern_d)+`
+`,i+="Quaternion Offsets:  x = "+this.qoffset_x+"  y = "+this.qoffset_y+"  z = "+this.qoffset_z+`
+`,i+="S-Form Parameters X: "+e(this.affine[0][0])+", "+e(this.affine[0][1])+", "+e(this.affine[0][2])+", "+e(this.affine[0][3])+`
+`,i+="S-Form Parameters Y: "+e(this.affine[1][0])+", "+e(this.affine[1][1])+", "+e(this.affine[1][2])+", "+e(this.affine[1][3])+`
+`,i+="S-Form Parameters Z: "+e(this.affine[2][0])+", "+e(this.affine[2][1])+", "+e(this.affine[2][2])+", "+e(this.affine[2][3])+`
+`,i+="Slice Code = "+this.slice_code+`
+`,i+="Units Code = "+this.xyzt_units+" ("+this.getUnitsCodeString(G.SPATIAL_UNITS_MASK&this.xyzt_units)+", "+this.getUnitsCodeString(G.TEMPORAL_UNITS_MASK&this.xyzt_units)+`)
+`,i+="Intent Code = "+this.intent_code+`
+`,i+='Intent Name: "'+this.intent_name+`"
+`,i+="Dim Info = "+this.dim_info+`
+`,i}getExtensionLocation=function(){return xe.MAGIC_COOKIE+4};getExtensionSize=G.prototype.getExtensionSize;getExtensionCode=G.prototype.getExtensionCode;addExtension=G.prototype.addExtension;removeExtension=G.prototype.removeExtension;getDatatypeCodeString=G.prototype.getDatatypeCodeString;getTransformCodeString=G.prototype.getTransformCodeString;getUnitsCodeString=G.prototype.getUnitsCodeString;getQformMat=G.prototype.getQformMat;convertNiftiQFormToNiftiSForm=G.prototype.convertNiftiQFormToNiftiSForm;convertNiftiSFormToNEMA=G.prototype.convertNiftiSFormToNEMA;nifti_mat33_mul=G.prototype.nifti_mat33_mul;nifti_mat33_determ=G.prototype.nifti_mat33_determ;toArrayBuffer(e=!1){let s=544;if(e)for(let l of this.extensions)s+=l.esize;let n=new Uint8Array(s),a=new DataView(n.buffer);a.setInt32(0,540,this.littleEndian),n.set(new TextEncoder().encode(this.magic),4),a.setInt16(12,this.datatypeCode,this.littleEndian),a.setInt16(14,this.numBitsPerVoxel,this.littleEndian);for(let l=0;l<8;l++)a.setBigInt64(16+8*l,BigInt(this.dims[l]),this.littleEndian);a.setFloat64(80,this.intent_p1,this.littleEndian),a.setFloat64(88,this.intent_p2,this.littleEndian),a.setFloat64(96,this.intent_p3,this.littleEndian);for(let l=0;l<8;l++)a.setFloat64(104+8*l,this.pixDims[l],this.littleEndian);a.setBigInt64(168,BigInt(this.vox_offset),this.littleEndian),a.setFloat64(176,this.scl_slope,this.littleEndian),a.setFloat64(184,this.scl_inter,this.littleEndian),a.setFloat64(192,this.cal_max,this.littleEndian),a.setFloat64(200,this.cal_min,this.littleEndian),a.setFloat64(208,this.slice_duration,this.littleEndian),a.setFloat64(216,this.toffset,this.littleEndian),a.setBigInt64(224,BigInt(this.slice_start),this.littleEndian),a.setBigInt64(232,BigInt(this.slice_end),this.littleEndian),n.set(new TextEncoder().encode(this.description),240),n.set(new TextEncoder().encode(this.aux_file),320),a.setInt32(344,this.qform_code,this.littleEndian),a.setInt32(348,this.sform_code,this.littleEndian),a.setFloat64(352,this.quatern_b,this.littleEndian),a.setFloat64(360,this.quatern_c,this.littleEndian),a.setFloat64(368,this.quatern_d,this.littleEndian),a.setFloat64(376,this.qoffset_x,this.littleEndian),a.setFloat64(384,this.qoffset_y,this.littleEndian),a.setFloat64(392,this.qoffset_z,this.littleEndian);const o=this.affine.flat();for(let l=0;l<12;l++)a.setFloat64(400+8*l,o[l],this.littleEndian);if(a.setInt32(496,this.slice_code,this.littleEndian),a.setInt32(500,this.xyzt_units,this.littleEndian),a.setInt32(504,this.intent_code,this.littleEndian),n.set(new TextEncoder().encode(this.intent_name),508),a.setUint8(524,this.dim_info),e){n.set(Uint8Array.from([1,0,0,0]),540);let l=this.getExtensionLocation();for(const c of this.extensions)a.setInt32(l,c.esize,c.littleEndian),a.setInt32(l+4,c.ecode,c.littleEndian),n.set(new 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ts",{});const e=Object.keys(ii).filter(i=>!i.startsWith("$")).sort(new Intl.Collator("en").compare);for(const i of e)this.cluts[i]=ii[i]}addColormap(t,e){this.cluts[t]=e}colormaps(){return Object.keys(this.cluts)}colorMaps(){return this.colormaps()}colormapFromKey(t){let e=this.cluts[t];return e!==void 0||(e=this.cluts[t.toLowerCase()],e!==void 0)?e:(t.length>0&&F.warn("No color map named "+t),{min:0,max:0,R:[0,255],G:[0,255],B:[0,255],A:[0,255],I:[0,255]})}colormap(t="",e=!1){const i=this.colormapFromKey(t);return this.makeLut(i.R,i.G,i.B,i.A,i.I,e)}makeLabelLut(t,e=255,i=1/0){if(t.R===void 0||t.G===void 0||t.B===void 0)throw new Error(`Invalid colormap table: ${t}`);const r=t.R.length,s=t.I??[...Array(r).keys()];let n=!1;for(let u=0;u<s.length;u++)s[u]>i&&(n=!0,s[u]=i);if(n&&F.warn("Some colormap indices clamped to match label range."),r!==t.G.length||r!==t.B.length||r!==s.length)throw new Error(`colormap does not make sense: ${t} Rs ${t.R.length} Gs ${t.G.length} Bs ${t.B.length} Is ${s.length}`);let a=new Uint8ClampedArray(r).fill(e);const o=s.indexOf(0);o>=0&&(a[o]=0),t.A!==void 0&&(a=Uint8ClampedArray.from(t.A));const l=Math.min(...s),c=Math.max(...s),h=c-l+1,d=new Uint8ClampedArray(h*4).fill(0);for(let u=0;u<r;u++){let m=(s[u]-l)*4;d[m++]=t.R[u],d[m++]=t.G[u],d[m++]=t.B[u],d[m++]=a[u]}const f={lut:d,min:l,max:c};if(t.labels){const u=t.labels.length;if(u===h)f.labels=t.labels;else if(u===r){f.labels=Array(h).fill("?");for(let m=0;m<r;m++)f.labels[s[m]-l]=t.labels[m]}}return f}async makeLabelLutFromUrl(t,e=255,i=1/0){const s=await(await fetch(t)).json();return this.makeLabelLut(s,e,i)}makeDrawLut(t){let e=typeof t=="object"?t:ii[t];e===void 0&&(F.warn("colormap undefined ",t),e=this.colormapFromKey(""));const i=this.makeLabelLut(e,255);if(i.labels===void 0&&(i.labels=[]),i.labels.length<256){const a=i.labels.length;for(let o=a;o<256;o++)i.labels.push(o.toString())}const r=new Uint8ClampedArray(256*4);let s=0;for(let a=0;a<256;a++)r[s++]=255,r[s++]=0,r[s++]=0,r[s++]=255;r[3]=0;const n=Math.min(i.lut.length,256*4);if(n>0)for(let a=0;a<n;a++)r[a]=i.lut[a];return{lut:r,labels:i.labels}}makeLut(t,e,i,r,s,n){const a=t.length,o=[...t],l=[...e],c=[...i];if(!s){s=new Array(a);for(let u=0;u<a;u++)s[u]=u/(a-1)*255}r||(r=new Array(a).fill(64),r[0]=0);let h=Uint8ClampedArray.from(r),d=Uint8ClampedArray.from(s);if(n)for(let u=0;u<a;u++)o[u]=t[a-1-u],l[u]=e[a-1-u],c[u]=i[a-1-u],h[u]=255-r[a-1-u],d[u]=255-s[a-1-u];const f=new Uint8ClampedArray(256*4);if(typeof d>"u"){d=new Uint8ClampedArray(a).fill(0);for(let u=0;u<a;u++)d[u]=Math.round(u*255/(a-1))}typeof h>"u"&&(h=new Uint8ClampedArray(a).fill(64),h[0]=0);for(let u=0;u<a-1;u++){const m=d[u];let p=d[u+1];u===0&&m!==0&&F.warn("colormap issue: indices expected to start with 0 not ",m),u===d.length-2&&p!==255&&(F.warn("padding colormap: indices expected end with 255 not ",p),p=255);const g=p-m;let x=m*4;for(let A=m;A<=p;A++){const y=(A-m)/g;f[x++]=o[u]+y*(o[u+1]-o[u]),f[x++]=l[u]+y*(l[u+1]-l[u]),f[x++]=c[u]+y*(c[u+1]-c[u]),f[x++]=h[u]+y*(h[u+1]-h[u])}}if(this.gamma===1)return f;for(let u=0;u<1020;u++)u%4!==3&&(f[u]=Math.pow(f[u]/255,1/this.gamma)*255);return f}},re=new Nc,$e=class{static getClusterBoundaryU8(t,e){const i=new Array(t.length).fill(!1),r=new Array(t.length).fill(!1);for(let a=0;a<t.length;a++)t[a]>0&&(r[a]=!0);const s=e.length/3;let n=0;for(let a=0;a<s;a++){const o=e[n],l=e[n+1],c=e[n+2];n+=3,!(r[o]===r[l]&&r[o]===r[c]&&r[l]===r[c])&&(i[o]=!0,i[l]=!0,i[c]=!0)}return i}static async gzip(t){const e=new CompressionStream("gzip"),i=e.writable.getWriter();i.write(t).catch(console.error);const r=i.close().catch(console.error),s=new Response(e.readable),n=new Uint8Array(await s.arrayBuffer());return await r,n}static createMZ3(t,e,i=!1,r=null,s=null,n=null){const f=e?e.length/3:0,u=t?t.length/3:0;if(!Number.isInteger(f)||f<0)throw new Error("indices length must be a multiple of 3");if(!Number.isInteger(u)||u<0)throw new Error("vertices length must be a multiple of 3");const m=e&&e.length>0,p=t&&t.length>0,g=r instanceof Uint8Array&&r.length===u*4;let x=null,A=0;if(n!=null){const R=typeof n=="string"?n:JSON.stringify(n);x=new TextEncoder().encode(R),A=x.byteLength}let y=!1,v=0;if(s!=null){if(!(s instanceof Float32Array))throw new Error("scalars must be a Float32Array or null/undefined");if(u===0)throw new Error("cannot have scalars without vertices (nvert === 0)");if(s.length>0&&s.length%u===0)y=!0,v=s.length/u;else throw new Error(`scalars.length (${s.length}) must be a positive integer multiple of nvert (${u})`)}let b=0;m&&(b|=1),p&&(b|=2),g&&(b|=4),y&&(b|=8),x&&(b|=64);const w=16,C=m?f*3*4:0,M=p?u*3*4:0,T=g?u*4:0,E=y?v*u*4:0,I=w+A+C+M+T+E,S=new ArrayBuffer(I),U=new DataView(S);let B=0;U.setUint16(B,23117,!0),B+=2,U.setUint16(B,b,!0),B+=2,U.setUint32(B,f,!0),B+=4,U.setUint32(B,u,!0),B+=4,U.setUint32(B,A,!0),B+=4;let V=w;if(A>0&&x&&(new Uint8Array(S,V,x.length).set(x),V+=A),m&&(new Uint32Array(S,V,e.length).set(e),V+=C),p&&(new Float32Array(S,V,t.length).set(t),V+=M),g&&(new Uint8Array(S,V,r.length).set(r),V+=T),y&&(new Float32Array(S,V,s.length).set(s),V+=E),V!==I)throw new Error(`mz3 internal size mismatch: offset ${V} !== totalSize ${I}`);if(i)throw new Error("Call async createMZ3Async() for compression");return S}static async createMZ3Async(t,e,i=!1,r=null,s=null,n=null){const a=this.createMZ3(t,e,i,r,s,n);return i?await this.gzip(new Uint8Array(a)):a}static createOBJ(t,e){let i="";for(let n=0;n<t.length;n+=3)i+=`v ${t[n]} ${t[n+1]} ${t[n+2]}
+`;for(let n=0;n<e.length;n+=3)i+=`f ${e[n]+1} ${e[n+1]+1} ${e[n+2]+1}
+`;return new TextEncoder().encode(i).buffer}static createSTL(t,e){const i=e.length/3,r=84+i*50,s=new ArrayBuffer(r),n=new DataView(s);for(let o=0;o<80;o++)n.setUint8(o,0);n.setUint32(80,i,!0);let a=84;for(let o=0;o<e.length;o+=3){const l=e[o]*3,c=e[o+1]*3,h=e[o+2]*3;n.setFloat32(a,0,!0),n.setFloat32(a+4,0,!0),n.setFloat32(a+8,0,!0),a+=12,n.setFloat32(a,t[l],!0),n.setFloat32(a+4,t[l+1],!0),n.setFloat32(a+8,t[l+2],!0),a+=12,n.setFloat32(a,t[c],!0),n.setFloat32(a+4,t[c+1],!0),n.setFloat32(a+8,t[c+2],!0),a+=12,n.setFloat32(a,t[h],!0),n.setFloat32(a+4,t[h+1],!0),n.setFloat32(a+8,t[h+2],!0),a+=12,n.setUint16(a,0,!0),a+=2}return s}static downloadArrayBuffer(t,e){const i=new Blob([t],{type:"application/octet-stream"}),r=URL.createObjectURL(i),s=document.createElement("a");s.href=r,s.download=e,document.body.appendChild(s),s.style.display="none",s.click(),setTimeout(()=>{document.body.removeChild(s),URL.revokeObjectURL(r)},0)}static async saveMesh(t,e,i=".mz3",r=!1){let s=new ArrayBuffer(0);return/\.obj$/i.test(i)?s=this.createOBJ(t,e):/\.stl$/i.test(i)?s=this.createSTL(t,e):(/\.mz3$/i.test(i)||(i+=".mz3"),s=await this.createMZ3Async(t,e,r)),i.length>4&&this.downloadArrayBuffer(s,i),s}static getClusterBoundary(t,e){const i=new Uint32Array(t.buffer),r=new Array(i.length).fill(!1),s=e.length/3;let n=0;for(let a=0;a<s;a++){const o=e[n],l=e[n+1],c=e[n+2];n+=3,!(i[o]===i[l]&&i[o]===i[c]&&i[l]===i[c])&&(r[o]=!0,r[l]=!0,r[c]=!0)}return r}static getExtents(t){if(!ArrayBuffer.isView(t)&&!Array.isArray(t)||t.length<3)return{mxDx:0,extentsMin:0,extentsMax:0};let e=0;const i=k(t[0],t[1],t[2]),r=k(t[0],t[1],t[2]);for(let a=0;a<t.length;a+=3){const o=k(t[a],t[a+1],t[a+2]);e=Math.max(e,Vt(o)),ur(i,i,o),mr(r,r,o)}const s=[i[0],i[1],i[2]],n=[r[0],r[1],r[2]];return{mxDx:e,extentsMin:s,extentsMax:n}}static generateNormals(t,e){const i=[];let r;const s=t.length;let n,a,o,l,c,h,d,f,u;const m=new Float32Array(s),p=e.length;for(r=0;r<p;r+=3){d=e[r]*3,f=e[r+1]*3,u=e[r+2]*3;const g=[t[d],t[d+1],t[d+2]],x=[t[f],t[f+1],t[f+2]],A=[t[u],t[u+1],t[u+2]];n=x[0]-g[0],a=x[1]-g[1],o=x[2]-g[2],l=A[0]-g[0],c=A[1]-g[1],h=A[2]-g[2],i[0]=c*o-h*a,i[1]=h*n-l*o,i[2]=l*a-c*n,m[d]+=i[0],m[d+1]+=i[1],m[d+2]+=i[2],m[f]+=i[0],m[f+1]+=i[1],m[f+2]+=i[2],m[u]+=i[0],m[u+1]+=i[1],m[u+2]+=i[2]}for(r=0;r<s;r+=3){i[0]=-1*m[r],i[1]=-1*m[r+1],i[2]=-1*m[r+2];let g=i[0]*i[0]+i[1]*i[1]+i[2]*i[2];g>0&&(g=1/Math.sqrt(g),i[0]*=g,i[1]*=g,i[2]*=g),m[r]=i[0],m[r+1]=i[1],m[r+2]=i[2]}return m}},Q,Ce,ri,$i,bt,An=class{constructor(t){lt(this,Q),lt(this,Ce,0),lt(this,ri,[]),lt(this,$i,[]),lt(this,bt),Ke(this,Q,new DataView(t)),this.read()}async extract(t){const e=new Uint8Array(X(this,Q).buffer.slice(t.startsAt,t.startsAt+t.compressedSize));if(t.compressionMethod===0)return e;if(t.compressionMethod===8){const i=new DecompressionStream("deflate-raw"),r=i.writable.getWriter();r.write(e).catch(console.error);const s=r.close().catch(console.error),n=new Response(i.readable),a=new Uint8Array(await n.arrayBuffer());return await s,a}throw new Error(`Unsupported compression method: ${t.compressionMethod}`)}read(){for(;!X(this,bt)&&X(this,Ce)<X(this,Q).byteLength;){const t=X(this,Q).getUint32(X(this,Ce),!0);if(t===67324752){const e=this.readLocalFile(X(this,Ce));e.extract=this.extract.bind(this,e),X(this,ri).push(e);const i=(e.generalPurpose&8)!==0;if(e.startsAt=X(this,Ce)+30+e.fileNameLength+e.extraLength,e.compressedSize===0&&i){let r=e.startsAt;for(;r+20<=X(this,Q).byteLength;){if(X(this,Q).getUint32(r,!0)===134695760&&X(this,Q).getUint16(r+16,!0)===19280){r+=4;break}r++}e.crc=X(this,Q).getUint32(r,!0),e.compressedSize=X(this,Q).getUint32(r+4,!0),e.uncompressedSize=X(this,Q).getUint32(r+8,!0),Ke(this,Ce,r+12)}else Ke(this,Ce,e.startsAt+e.compressedSize)}else if(t===33639248){const e=this.readCentralDirectory(X(this,Ce));X(this,$i).push(e),Ke(this,Ce,X(this,Ce)+(46+e.fileNameLength+e.extraLength+e.fileCommentLength))}else if(t===101010256){Ke(this,bt,this.readEndCentralDirectory(X(this,Ce)));break}else if(t===101075792){Ke(this,bt,this.readEndCentralDirectory64(X(this,Ce)));break}else{console.error(`Unexpected ZIP signature 0x${t.toString(16).padStart(8,"0")} at index ${X(this,Ce)}`);break}}}readLocalFile(t){let e=X(this,Q).getUint32(t+18,!0),i=X(this,Q).getUint32(t+22,!0);const r=X(this,Q).getUint16(t+26,!0),s=X(this,Q).getUint16(t+28,!0),n=t+30+r;if(this.readString(n,s),e===4294967295&&i===4294967295){let a=n,o=!1;for(;a<n+s-4;){const l=X(this,Q).getUint16(a,!0),c=X(this,Q).getUint16(a+2,!0);if(a+=4,l===1)if(c>=16){i=Number(X(this,Q).getBigUint64(a,!0)),a+=8,e=Number(X(this,Q).getBigUint64(a,!0)),o=!0;break}else throw new Error(`ZIP64 extra field found but is too small (expected at least 16 bytes, got ${c}).`);a+=c}if(!o)throw new Error("ZIP64 format missing extra field with signature 0x0001.")}return{signature:this.readString(t,4),version:X(this,Q).getUint16(t+4,!0),generalPurpose:X(this,Q).getUint16(t+6,!0),compressionMethod:X(this,Q).getUint16(t+8,!0),lastModifiedTime:X(this,Q).getUint16(t+10,!0),lastModifiedDate:X(this,Q).getUint16(t+12,!0),crc:X(this,Q).getUint32(t+14,!0),compressedSize:e,uncompressedSize:i,fileNameLength:r,extraLength:s,fileName:this.readString(t+30,r),extra:this.readString(t+30+r,s)}}readCentralDirectory(t){return{versionCreated:X(this,Q).getUint16(t+4,!0),versionNeeded:X(this,Q).getUint16(t+6,!0),fileNameLength:X(this,Q).getUint16(t+28,!0),extraLength:X(this,Q).getUint16(t+30,!0),fileCommentLength:X(this,Q).getUint16(t+32,!0),diskNumber:X(this,Q).getUint16(t+34,!0),internalAttributes:X(this,Q).getUint16(t+36,!0),externalAttributes:X(this,Q).getUint32(t+38,!0),offset:X(this,Q).getUint32(t+42,!0),comments:this.readString(t+46,X(this,Q).getUint16(t+32,!0))}}readEndCentralDirectory(t){const e=X(this,Q).getUint16(t+20,!0);return{numberOfDisks:X(this,Q).getUint16(t+4,!0),centralDirectoryStartDisk:X(this,Q).getUint16(t+6,!0),numberCentralDirectoryRecordsOnThisDisk:X(this,Q).getUint16(t+8,!0),numberCentralDirectoryRecords:X(this,Q).getUint16(t+10,!0),centralDirectorySize:X(this,Q).getUint32(t+12,!0),centralDirectoryOffset:X(this,Q).getUint32(t+16,!0),commentLength:e,comment:this.readString(t+22,e)}}readEndCentralDirectory64(t){const e=Number(X(this,Q).getBigUint64(t+0,!0));return{numberOfDisks:X(this,Q).getUint32(t+16,!0),centralDirectoryStartDisk:X(this,Q).getUint32(t+20,!0),numberCentralDirectoryRecordsOnThisDisk:Number(X(this,Q).getBigUint64(t+24,!0)),numberCentralDirectoryRecords:Number(X(this,Q).getBigUint64(t+32,!0)),centralDirectorySize:Number(X(this,Q).getBigUint64(t+40,!0)),centralDirectoryOffset:Number(X(this,Q).getBigUint64(t+48,!0)),commentLength:e,comment:""}}readString(t,e){return Array.from({length:e},(i,r)=>String.fromCharCode(X(this,Q).getUint8(t+r))).join("")}get entries(){return X(this,ri)}};Q=new WeakMap;Ce=new WeakMap;ri=new WeakMap;$i=new WeakMap;bt=new WeakMap;var H=class ct{static arrayBufferToBase64(e){const i=new Uint8Array(e);return ct.uint8tob64(i)}static async decompress(e){const i=e[0]===31&&e[1]===139&&e[2]===8?"gzip":e[0]===120&&(e[1]===1||e[1]===94||e[1]===156||e[1]===218)?"deflate":"deflate-raw",r=new DecompressionStream(i),s=r.writable.getWriter();s.write(e).catch(console.error);const n=s.close().catch(console.error),a=new Response(r.readable),o=new Uint8Array(await a.arrayBuffer());return await n,o}static async decompressToBuffer(e){const i=await ct.decompress(e);return i.buffer.slice(i.byteOffset,i.byteOffset+i.byteLength)}static async readMatV4(e,i=!1){let r=e.byteLength;if(r<40)throw new Error("File too small to be MAT v4: bytes = "+e.byteLength);let s=new DataView(e),n=s.getUint16(0,!0),a=e;if(n===35615||n===8075){const m=await this.decompress(new Uint8Array(e));s=new DataView(m.buffer),n=s.getUint16(0,!0),a=m.buffer,r=a.byteLength}const o=new TextDecoder("utf-8"),l=new Uint8Array(a);let c=0;const h={};function d(m){return Math.floor(m/10)%10}function f(m,p,g){const x=new Uint8Array(l.subarray(p,g));return m===1?new Float32Array(x.buffer):m===2?new Int32Array(x.buffer):m===3?new Int16Array(x.buffer):m===4?new Uint16Array(x.buffer):m===5?new Uint8Array(x.buffer):new Float64Array(x.buffer)}function u(){const m=s.getUint32(c,!0),p=s.getUint32(c+4,!0),g=s.getUint32(c+8,!0),x=s.getUint32(c+12,!0),A=s.getUint32(c+16,!0);if(c+=20,x!==0)throw new Error("Matlab V4 reader does not support imaginary numbers");const y=p*g;if(y<1)throw new Error("mrows * ncols must be greater than one");const v=new Uint8Array(l.subarray(c,c+A));let b=o.decode(v).trim().replaceAll("\0","");i&&(b=b.replaceAll(".","_"));const w=d(m);let C=8;if(w>=1&&w<=2)C=4;else if(w>=3&&w<=4)C=2;else if(w===5)C=1;else if(w!==0)throw new Error("impossible Matlab v4 datatype");if(c+=A,m>50)throw new Error("Does not appear to be little-endian V4 Matlab file");const M=c+y*C;h[b]=f(w,c,M),c=M}for(;c+20<r;)u();return h}static b64toUint8(e){const i=atob(e),r=i.length,s=new Uint8Array(r);for(let n=0;n<r;n++)s[n]=i.charCodeAt(n);return s}static uint8tob64(e){let i="";const r="ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/",s=e.byteLength,n=s%3,a=s-n;let o,l,c,h,d;for(let f=0;f<a;f=f+3)d=e[f]<<16|e[f+1]<<8|e[f+2],o=(d&16515072)>>18,l=(d&258048)>>12,c=(d&4032)>>6,h=d&63,i+=r[o]+r[l]+r[c]+r[h];return n===1?(d=e[a],o=(d&252)>>2,l=(d&3)<<4,i+=r[o]+r[l]+"=="):n===2&&(d=e[a]<<8|e[a+1],o=(d&64512)>>10,l=(d&1008)>>4,c=(d&15)<<2,i+=r[o]+r[l]+r[c]+"="),i}static download(e,i,r){const s=document.createElement("a"),n=Array.isArray(e)?e:[e],a=new Blob(n,{type:r});s.href=URL.createObjectURL(a),s.download=i,s.click()}static readFileAsync(e){return new Promise((i,r)=>{const s=new FileReader;s.onload=()=>{i(s.result)},s.onerror=r,s.readAsArrayBuffer(e)})}static blobToBase64(e){return new Promise(i=>{const r=new FileReader;r.onloadend=()=>i(r.result),r.readAsDataURL(e)})}static async decompressBase64String(e){const i=atob(e),r=new ArrayBuffer(i.length),s=new Uint8Array(r);for(let n=0;n<i.length;n++)s[n]=i.charCodeAt(n);return ct.decompressArrayBuffer(s)}static async compressToBase64String(e){const i=await ct.compressStringToArrayBuffer(e);return ct.uint8tob64(new Uint8Array(i))}static strToU8(e,i){if(i){const l=new Uint8Array(e.length);for(let c=0;c<e.length;++c)l[c]=e.charCodeAt(c);return l}const r=e.length,s=(l,c,h)=>((h==null||h>l.length)&&(h=l.length),new Uint8Array(l.subarray(c,h)));let n=new Uint8Array(e.length+(e.length>>1)),a=0;const o=l=>{n[a++]=l};for(let l=0;l<r;++l){if(a+5>n.length){const h=new Uint8Array(a+8+(r-l<<1));h.set(n),n=h}let c=e.charCodeAt(l);c<128||i?o(c):c<2048?(o(192|c>>6),o(128|c&63)):(c>55295&&c<57344,c=65536+(c&1047552)|e.charCodeAt(++l)&1023,o(240|c>>18),o(128|c>>12&63),o(128|c>>6&63),o(128|c&63))}return s(n,0,a)}static async compress(e,i="gzip"){const r=new CompressionStream(i),s=r.writable.getWriter();s.write(e).catch(console.error);const n=s.close().catch(console.error),o=await new Response(r.readable).arrayBuffer();return await n,o}static async compressStringToArrayBuffer(e){const i=this.strToU8(e);return await this.compress(i)}static isArrayBufferCompressed(e){if(e&&e.byteLength){const i=new Uint8Array(e);return(i[0]<<8|i[1])===8075}else return!1}static strFromU8(e,i){if(i){let r="";for(let s=0;s<e.length;s+=16384)r+=String.fromCharCode.apply(null,e.subarray(s,s+16384));return r}else{const r=(o,l,c)=>((l==null||l<0)&&(l=0),(c==null||c>o.length)&&(c=o.length),new Uint8Array(o.subarray(l,c))),s=o=>{for(let l="",c=0;;){let h=o[c++];const d=(h>127)+(h>223)+(h>239);if(c+d>o.length)return{s:l,r:r(o,c-1)};d?d===3?(h=((h&15)<<18|(o[c++]&63)<<12|(o[c++]&63)<<6|o[c++]&63)-65536,l+=String.fromCharCode(55296|h>>10,56320|h&1023)):d&1?l+=String.fromCharCode((h&31)<<6|o[c++]&63):l+=String.fromCharCode((h&15)<<12|(o[c++]&63)<<6|o[c++]&63):l+=String.fromCharCode(h)}},{s:n,r:a}=s(e);if(a.length)throw new Error("Unexpected trailing bytes in UTF-8 decoding");return n}}static async decompressArrayBuffer(e){const i=await this.decompress(new Uint8Array(e));return this.strFromU8(i)}static arraysAreEqual(e,i){return za(e,i)}static range(e,i,r){return Array.from({length:(i-e)/r+1},(s,n)=>e+n*r)}static sph2cartDeg(e,i){const r=-i*(Math.PI/180),s=(e-90)%360*(Math.PI/180),n=[Math.cos(r)*Math.cos(s),Math.cos(r)*Math.sin(s),Math.sin(r)],a=Math.sqrt(n[0]*n[0]+n[1]*n[1]+n[2]*n[2]);return a<=0||(n[0]/=a,n[1]/=a,n[2]/=a),n}static vox2mm(e,i){const r=de(i);Te(r,r);const s=ae(e[0],e[1],e[2],1);return ve(s,s,r),k(s[0],s[1],s[2])}},vt=F,ce=class fe{static readTRACT(e){const i=e.byteLength;if(i<20)throw new Error("File too small to be niml.tract: bytes = "+i);const r=new DataView(e),s=new Uint8Array(e);let n=0;function a(){for(;n<i&&s[n]!==60;)n++;const p=n;for(;n<i&&s[n]!==62;)n++;return n++,n-p<1?"":new TextDecoder().decode(e.slice(p,n-1)).trim()}let o=a();function l(p){const g=o.indexOf(p);if(g<0)return 0;const x=o.indexOf('"',g)+1,A=o.indexOf('"',x),y=o.slice(x,A);return parseInt(y)}const c=l("N_tracts=");(!o.startsWith("<network")||c<1)&&F.warn("This is not a valid niml.tract file "+o);let h=0;const d=[];d.push(h);const f=[],u=[];for(let p=0;p<c;p++){o=a();const g=l("ni_dimen="),x=l("Bundle_Tag="),A=o.includes("binary.lsbfirst");for(let y=0;y<g;y++){n+=4;const v=r.getUint32(n,A)/3;n+=4;for(let b=0;b<v;b++)f.push(r.getFloat32(n,A)),n+=4,f.push(-r.getFloat32(n,A)),n+=4,f.push(r.getFloat32(n,A)),n+=4;h+=v,d.push(h),u.push(x)}o=a()}const m=[];return m.push({id:"tract",vals:Float32Array.from(u)}),{pts:new Float32Array(f),offsetPt0:new Uint32Array(d),dps:m}}static async readTT(e){let i=new Uint32Array(0),r=new Float32Array(0);const s=await H.readMatV4(e);if(!("trans_to_mni"in s))throw new Error("TT format file must have 'trans_to_mni'");if(!("voxel_size"in s))throw new Error("TT format file must have 'voxel_size'");if(!("track"in s))throw new Error("TT format file must have 'track'");let n=J();const a=s.trans_to_mni;n=Ee(a[0],a[1],a[2],a[3],a[4],a[5],a[6],a[7],a[8],a[9],a[10],a[11],a[12],a[13],a[14],a[15]),Te(n,n);function o(l){const c=new DataView(l.buffer),h=[];let d=0,f=0;for(;f<l.length;){h.push(f);const p=c.getUint32(f,!0);f=f+p+13,d+=p}i=new Uint32Array(h.length+1),r=new Float32Array(d);let u=0;for(let p=0;p<h.length;p++){i[p]=u/3;let g=h[p];const x=c.getUint32(g,!0)/3;let A=c.getInt32(g+4,!0),y=c.getInt32(g+8,!0),v=c.getInt32(g+12,!0);g+=16,r[u++]=A,r[u++]=y,r[u++]=v;for(let b=2;b<=x;b++)A=A+c.getInt8(g++),y=y+c.getInt8(g++),v=v+c.getInt8(g++),r[u++]=A,r[u++]=y,r[u++]=v}for(let p=0;p<u;p++)r[p]=r[p]/32;let m=0;for(let p=0;p<u/3;p++){const g=ae(r[m],r[m+1],r[m+2],1);ve(g,g,n),r[m++]=g[0],r[m++]=g[1],r[m++]=g[2]}i[h.length]=u/3}return o(s.track),{pts:r,offsetPt0:i}}static assembleDpgFromMap(e,i){if(!Array.isArray(i)||i.length===0)throw new Error('assembleDpgFromMap: "groups" is empty or missing; cannot assemble dpg.');const r=new Set;for(const n in e)e[n].forEach(a=>r.add(a.id));const s=[];for(const n of r){const a=[];let o=0;for(let h=0;h<i.length;h++){const d=String(i[h].id),u=(e[d]||[]).find(m=>m.id===n);if(u){const m=u.vals instanceof Float32Array?u.vals:Float32Array.from(u.vals);a.push(m),o+=m.length}else{const m=new Float32Array([NaN]);a.push(m),o+=m.length}}const l=new Float32Array(o);let c=0;for(const h of a)l.set(h,c),c+=h.length;s.push({id:n,vals:l})}return s}static async readTRX(e){function i(p){const g=(p&31744)>>10,x=p&1023;return(p>>15?-1:1)*(g?g===31?x?NaN:1/0:Math.pow(2,g-15)*(1+x/1024):6103515625e-14*(x/1024))}let r=0,s=0,n=new Float32Array([]);const a=[],o={},l=[],c=[],h=[];let d=[],f=!1;const u=new An(e);for(let p=0;p<u.entries.length;p++){const g=u.entries[p];if(g.uncompressedSize===0)continue;const x=g.fileName.split("/"),A=x.slice(-1)[0];if(A.startsWith("."))continue;const y=x.slice(-3)[0],v=x.slice(-2)[0],b=A.split(".")[0],w=await g.extract();if(A.includes("header.json")){const T=new TextDecoder().decode(w);d=JSON.parse(T);continue}let C=0,M=[];if(A.endsWith(".uint64")||A.endsWith(".int64")){C=w.length/8,M=new Uint32Array(C);const T=new Uint32Array(w.buffer);let E=0;for(let I=0;I<C;I++)M[I]=T[E],T[E+1]!==0&&(f=!0),E+=2}else if(A.endsWith(".uint32"))M=new Uint32Array(w.buffer);else if(A.endsWith(".uint16"))M=new Uint16Array(w.buffer);else if(A.endsWith(".uint8"))M=new Uint8Array(w.buffer);else if(A.endsWith(".int32"))M=new Int32Array(w.buffer);else if(A.endsWith(".int16"))M=new Int16Array(w.buffer);else if(A.endsWith(".int8"))M=new Int8Array(w.buffer);else if(A.endsWith(".float64"))M=new Float64Array(w.buffer);else if(A.endsWith(".float32"))M=new Float32Array(w.buffer);else if(A.endsWith(".float16")){C=w.length/2,M=new Float32Array(C);const T=new Uint16Array(w.buffer),E=new Float32Array(65536);for(let I=0;I<65536;I++)E[I]=i(I);for(let I=0;I<C;I++)M[I]=E[T[I]]}else continue;if(C=M.length,v.includes("groups")){l.push({id:b,vals:Float32Array.from(M.slice())});continue}if(y.includes("dpg")){const T=String(v);o[T]||(o[T]=[]),o[T].push({id:b,vals:Float32Array.from(M.slice())});continue}if(v.includes("dpv")){h.push({id:b,vals:Float32Array.from(M.slice())});continue}if(v.includes("dps")){c.push({id:b,vals:Float32Array.from(M.slice())});continue}if(A.startsWith("offsets.")){r=C;for(let T=0;T<C;T++)a[T]=M[T]}A.startsWith("positions.3.")&&(s=C,n=new Float32Array(M))}if(r===0||s===0)throw new Error("Failure reading TRX format (no offsets or points).");if(f)throw new Error("Too many vertices: JavaScript does not support 64 bit integers");let m=[];return l.length>0&&o&&Object.keys(o).length>0&&(m=this.assembleDpgFromMap(o,l)),a[r]=s/3,{pts:n,offsetPt0:new Uint32Array(a),dpg:m,dps:c,dpv:h,groups:l,header:d}}static readTXT(e,i=0){const s=new TextDecoder("utf-8").decode(e).split(/\r?\n|\r/).filter(a=>a.trim().length>0);i<=0&&(i=s.length);const n=new Float32Array(i);for(let a=0;a<i&&a<s.length;a++){const o=parseFloat(s[a].trim());n[a]=Number.isFinite(o)?o:0}return n}static readTSF(e,i=0){const r=new Float32Array(i),s=e.byteLength;if(s<20)throw new Error("File too small to be TSF: bytes = "+s);const n=new Uint8Array(e);let a=0;function o(){for(;a<s&&n[a]===10;)a++;const f=a;for(;a<s&&n[a]!==10;)a++;return a++,a-f<1?"":new TextDecoder().decode(e.slice(f,a-1))}let l=o();if(!l.includes("mrtrix track scalars"))throw new Error("Not a valid TSF file");let c=-1;for(;a<s&&!l.includes("END");)if(l=o(),l.toLowerCase().startsWith("file:")&&(c=parseInt(l.split(" ").pop())),l.toLowerCase().startsWith("datatype:")&&!l.endsWith("Float32LE"))throw new Error("Only supports TSF files with Float32LE");if(c<20)throw new Error("Not a valid TSF file (missing file offset)");a=c;const h=new DataView(e);let d=0;for(;a+4<=s&&d<i;){const f=h.getFloat32(a,!0);if(a+=4,isFinite(f))r[d++]=f;else if(!isNaN(f))break}return r}static readTCK(e){const i=e.byteLength;if(i<20)throw new Error("File too small to be TCK: bytes = "+i);const r=new Uint8Array(e);let s=0;function n(){for(;s<i&&r[s]===10;)s++;const m=s;for(;s<i&&r[s]!==10;)s++;return s++,s-m<1?"":new TextDecoder().decode(e.slice(m,s-1))}let a=n();if(!a.includes("mrtrix tracks"))throw new Error("Not a valid TCK file");let o=-1;for(;s<i&&!a.includes("END");)a=n(),a.toLowerCase().startsWith("file:")&&(o=parseInt(a.split(" ").pop()));if(o<20)throw new Error("Not a valid TCK file (missing file offset)");s=o;const l=new DataView(e);let c=0,h=new Uint32Array(i/16),d=0,f=0,u=new Float32Array(i/4);for(h[0]=0;s+12<i;){const m=l.getFloat32(s,!0);s+=4;const p=l.getFloat32(s,!0);s+=4;const g=l.getFloat32(s,!0);if(s+=4,isFinite(m))u[f++]=m,u[f++]=p,u[f++]=g,c++;else if(h[d++]=c,!isNaN(m))break}return u=u.slice(0,f),h=h.slice(0,d),{pts:u,offsetPt0:h}}static async readTRK(e){let i=new DataView(e),r=i.getUint32(0,!0);if(r!==1128354388){let I;if(r===4247762216)throw new Error("zstd TRK decompression is not supported");I=await H.decompress(new Uint8Array(e)),e=I.buffer,i=new DataView(e),r=i.getUint32(0,!0)}const s=i.getUint32(992,!0),n=i.getUint32(996,!0);if(s>3||n!==1e3||r!==1128354388)throw new Error(`Not a valid TRK file expected version ≤3 (${s}), header size 1000 (${n}) and magic of 1128354388 (${r})`);const a=i.getInt16(36,!0),o=[];for(let I=0;I<a;I++){const S=new Uint8Array(e.slice(38+I*20,58+I*20)),U=new TextDecoder().decode(S).split("\0").shift();o.push({id:U.trim(),vals:[]})}const l=i.getFloat32(12,!0),c=i.getFloat32(16,!0),h=i.getFloat32(20,!0),d=Ee(1/l,0,0,-.5,0,1/c,0,-.5,0,0,1/h,-.5,0,0,0,1),f=i.getInt16(238,!0),u=[];for(let I=0;I<f;I++){const S=new Uint8Array(e.slice(240+I*20,260+I*20)),U=new TextDecoder().decode(S).split("\0").shift();u.push({id:U.trim(),vals:[]})}const m=J();for(let I=0;I<16;I++)m[I]=i.getFloat32(440+I*4,!0);m[15]===0&&(F.warn("TRK vox_to_ras not set"),qs(m));const p=J();Qs(p,d,m);let g=null,x=null;g=new Int32Array(e.slice(n)),x=new Float32Array(g.buffer);const A=g.length;if(A<1)throw new Error("Empty TRK file.");let y=0,v=0,b=new Uint32Array(g.length/4),w=0,C=new Float32Array(g.length),M=0;for(;y<A;){const I=g[y];y=y+1,b[w++]=v;for(let S=0;S<I;S++){const U=x[y+0],B=x[y+1],V=x[y+2];if(y+=3,C[M++]=U*p[0]+B*p[1]+V*p[2]+p[3],C[M++]=U*p[4]+B*p[5]+V*p[6]+p[7],C[M++]=U*p[8]+B*p[9]+V*p[10]+p[11],a>0)for(let R=0;R<a;R++)o[R].vals.push(x[y]),y++;v++}if(f>0)for(let S=0;S<f;S++)u[S].vals.push(x[y]),y++}const T=[];for(let I=0;I<u.length;I++)T.push({id:u[I].id,vals:Float32Array.from(u[I].vals)});const E=[];for(let I=0;I<o.length;I++)E.push({id:o[I].id,vals:Float32Array.from(o[I].vals)});return b[w++]=v,C=C.slice(0,M),b=b.slice(0,w),{pts:C,offsetPt0:b,dps:T,dpv:E}}static readTxtVTK(e){const s=new TextDecoder("utf-8").decode(e).split(`
+`);if(s.length<7||!s[0].startsWith("# vtk DataFile"))throw new Error("Invalid VTK image");if(!s[2].startsWith("ASCII"))throw new Error("Not ASCII VTK mesh");let a=3;for(;s[a].length<1;)a++;if(!s[a].includes("POLYDATA"))throw new Error("Not ASCII VTK polydata");for(a++;s[a].length<1;)a++;if(!s[a].startsWith("POINTS"))throw new Error("Not VTK POINTS");let o=s[a].trim().split(/\s+/);const l=parseInt(o[1]),c=l*3,h=new Float32Array(l*3);let d=0;for(;d<l*3;){a++;const p=s[a].trim().trim().split(/\s+/);for(let g=0;g<p.length&&!(d>=c);g++)h[d]=parseFloat(p[g]),d++}const f=[];for(a++;s[a].length<1;)a++;if(s[a].startsWith("METADATA")){for(;s[a].length>1;)a++;a++}if(o=s[a].trim().split(/\s+/),a++,o[0].includes("LINES")){const m=parseInt(o[1]);if(m<1)throw new Error("Corrupted VTK ASCII");let p=s[a].trim();const g=[];let x=[];if(p.startsWith("OFFSETS")){a++;let A=0;for(;A<m;){p=s[a].trim(),a++;const y=p.trim().split(/\s+/);for(let v=0;v<y.length&&(g[A]=parseInt(y[v]),A++,!(A>=m));v++);}x=Array.from(h)}else{let A=function(){p=s[a].trim();const w=p.trim().split(/\s+/);v=[];for(let C=0;C<w.length;C++)v.push(parseInt(w[C]));b=0,a++},y=0;g[0]=0;let v=[],b=0;A();for(let w=0;w<m;w++){b>=v.length&&A();const C=v[b++];y+=C,g[w+1]=y;for(let M=0;M<C;M++){b>=v.length&&A();const T=v[b++]*3;x.push(h[T+0]),x.push(h[T+1]),x.push(h[T+2])}}}return{pts:Float32Array.from(x),offsetPt0:Uint32Array.from(g)}}else if(o[0].includes("TRIANGLE_STRIPS")){const m=parseInt(o[1]);for(let p=0;p<m;p++){const g=s[a].trim();a++;const x=g.trim().split(/\s+/),A=parseInt(x[0])-2;let y=1;for(let v=0;v<A;v++)v%2?(f.push(parseInt(x[y+2])),f.push(parseInt(x[y+1])),f.push(parseInt(x[y]))):(f.push(parseInt(x[y])),f.push(parseInt(x[y+1])),f.push(parseInt(x[y+2]))),y+=1}}else if(o[0].includes("POLYGONS")){const m=parseInt(o[1]);for(let p=0;p<m;p++){const g=s[a].trim();a++;const x=g.trim().split(/\s+/),A=parseInt(x[0])-2,y=parseInt(x[1]);let v=parseInt(x[2]);for(let b=0;b<A;b++){const w=parseInt(x[3+b]);f.push(y),f.push(v),f.push(w),v=w}}}else throw new Error("Unsupported ASCII VTK datatype "+o[0]);const u=new Uint32Array(f);return{positions:h,indices:u}}static async readLayer(e="",i,r,s=.5,n="warm",a="winter",o=!1,l=null,c=null,h=0){const d={...zc,colormapInvert:!1,colormapType:0,isTransparentBelowCalMin:!0,isAdditiveBlend:!1,colorbarVisible:!0,colormapLabel:null},f=/(?:\.([^.]+))?$/;let u=f.exec(e)[1];u=u.toUpperCase(),u==="GZ"&&(u=f.exec(e.slice(0,-3))[1],u=u.toUpperCase());const m=r.vertexCount/3;if(r.offsetPt0){const x=e.split("/");let A="Unknown";if(x.length>1&&x.pop()&&(A=A.split(".").slice(0,-1).join(".")),u==="TXT"){const C=r.offsetPt0.length-1,M=fe.readTXT(i,C);if(M.length!==C)throw new Error(`TXT file has ${M.length} items, expected one per streamline (${C}).`);r.dps||(r.dps=[]);const T=M.reduce((I,S)=>Math.min(I,S)),E=M.reduce((I,S)=>Math.max(I,S));return r.dps.push({id:A,vals:Float32Array.from(M.slice()),global_min:T,global_max:E,cal_min:T,cal_max:E}),d}if(u==="NII"){const C=await fe.readNII(i,r.pts,""),M=C.reduce((E,I)=>Math.min(E,I)),T=C.reduce((E,I)=>Math.max(E,I));return r.dpv.push({id:A,vals:Float32Array.from(C.slice()),global_min:M,global_max:T,cal_min:M,cal_max:T}),d}if(u!=="TSF")throw new Error("readLayer for streamlines only supports TSF and TXT files.");const y=r.pts.length/3,v=fe.readTSF(i,y);r.dpv||(r.dpv=[]);const b=v.reduce((C,M)=>Math.min(C,M)),w=v.reduce((C,M)=>Math.max(C,M));return r.dpv.push({id:A,vals:Float32Array.from(v.slice()),global_min:b,global_max:w,cal_min:b,cal_max:w}),d}if(m<3){F.error("n_vert < 3 in layer");return}if(u==="MZ3"){const x=await fe.readMZ3(i,m);d.values=x.scalars,"colormapLabel"in x&&(d.colormapLabel=x.colormapLabel)}else if(u==="ANNOT"){const x=fe.readANNOT(i,m,!0);x instanceof Uint32Array?d.values=x:(d.values=x.scalars,d.colormapLabel=x.colormapLabel)}else if(u==="CRV"||u==="CURV"||u==="THICKNESS"||u==="AREA")d.values=fe.readCURV(i,m),d.isTransparentBelowCalMin=!1;else if(u==="GII"){const x=await fe.readGII(i,m);d.values=x.scalars,d.colormapLabel=x.colormapLabel}else if(u==="MGH"||u==="MGZ"){const x=await fe.readMGH(i,m,!0);"scalars"in x?(d.values=x.scalars,d.colormapLabel=x.colormapLabel):d.values=x}else if(u==="NII")d.values=await fe.readNII(i,r.pts,r.anatomicalStructurePrimary);else if(u==="SMP")d.values=await fe.readSMP(i,m);else if(u==="STC")d.values=fe.readSTC(i,m);else if(fe.isCurv(i))d.values=fe.readCURV(i,m),d.isTransparentBelowCalMin=!1;else return F.warn("Unknown layer overlay format "+e),d;if(!d.values){F.error("no values in layer");return}d.nFrame4D=d.values.length/m,d.frame4D=0,d.outlineBorder=h;let p=d.values[0],g=d.values[0];for(let x=0;x<d.values.length;x++)p=Math.min(p,d.values[x]),g=Math.max(g,d.values[x]);return d.global_min=p,d.global_max=g,d.cal_min=l||0,l||(d.cal_min=p),d.cal_max=c||0,c||(d.cal_max=g),d.cal_minNeg=NaN,d.cal_maxNeg=NaN,d.opacity=s,d.colormap=n,d.colormapNegative=a,d.useNegativeCmap=o,d}static async readSMP(e,i){const r=e.byteLength;let s=new DataView(e),n=s.getUint16(0,!0);if(n>5){const d=await H.decompress(new Uint8Array(e));s=new DataView(d.buffer),n=s.getUint16(0,!0),e=d.buffer}n>5&&F.error("Unsupported or invalid BrainVoyager SMP version "+n);const a=s.getUint32(2,!0);a!==i&&F.error("SMP file has "+a+" vertices, background mesh has "+i);const o=s.getUint16(6,!0),l=new Float32Array(a*o);let c=9;function h(){const d=c;for(;c<r&&s.getUint8(c)!==0;)c++;return c++,new TextDecoder().decode(e.slice(d,c-1))}h();for(let d=0;d<o;d++){const f={};f.mapType=s.getUint32(c,!0),c+=4,n>=3&&f.mapType===3&&(f.nLags=s.getUint32(c,!0),c+=4,f.mnLag=s.getUint32(c,!0),c+=4,f.mxLag=s.getUint32(c,!0),c+=4,f.ccOverlay=s.getUint32(c,!0),c+=4),f.clusterSize=s.getUint32(c,!0),c+=4,f.clusterCheck=s.getUint8(c),c+=1,f.critThresh=s.getFloat32(c,!0),c+=4,f.maxThresh=s.getFloat32(c,!0),c+=4,n>=4&&(f.includeValuesGreaterThreshMax=s.getUint32(c,!0),c+=4),f.df1=s.getUint32(c,!0),c+=4,f.df2=s.getUint32(c,!0),c+=4,n>=5?(f.posNegFlag=s.getUint32(c,!0),c+=4):f.posNegFlag=3,f.cortexBonferroni=s.getUint32(c,!0),c+=4,f.posMinRGB=[0,0,0],f.posMaxRGB=[0,0,0],f.negMinRGB=[0,0,0],f.negMaxRGB=[0,0,0],n>=2&&(f.posMinRGB[0]=s.getUint8(c),c++,f.posMinRGB[1]=s.getUint8(c),c++,f.posMinRGB[2]=s.getUint8(c),c++,f.posMaxRGB[0]=s.getUint8(c),c++,f.posMaxRGB[1]=s.getUint8(c),c++,f.posMaxRGB[2]=s.getUint8(c),c++,n>=4&&(f.negMinRGB[0]=s.getUint8(c),c++,f.negMinRGB[1]=s.getUint8(c),c++,f.negMinRGB[2]=s.getUint8(c),c++,f.negMaxRGB[0]=s.getUint8(c),c++,f.negMaxRGB[1]=s.getUint8(c),c++,f.negMaxRGB[2]=s.getUint8(c),c++),f.enableSMPColor=s.getUint8(c),c++,n>=4&&(f.lut=h()),f.colorAlpha=s.getFloat32(c,!0),c+=4),f.name=h();const u=new Float32Array(e,c,a);l.set(u,d*a),c+=a*4}return l}static readSTC(e,i){const r=new DataView(e),s=r.getInt32(8,!1);if(s!==i)throw new Error("Overlay has "+s+" vertices, expected "+i);let n=12+s*4;const a=r.getUint32(n,!1);n+=4;const o=new Float32Array(a*s);for(let l=0;l<a*s;l++)o[l]=r.getFloat32(n,!1),n+=4;return o}static isCurv(e){const i=new DataView(e),r=i.getUint8(0),s=i.getUint8(1),n=i.getUint8(2);return r!==255||s!==255||n!==255?(vt.debug("Unable to recognize file type: does not appear to be FreeSurfer format."),!1):!0}static readCURV(e,i){const r=new DataView(e),s=r.getUint8(0),n=r.getUint8(1),a=r.getUint8(2),o=r.getUint32(3,!1),l=r.getUint32(11,!1);if((s!==255||n!==255||a!==255)&&vt.debug("Unable to recognize file type: does not appear to be FreeSurfer format."),i!==o)throw new Error("CURV file has different number of vertices ( "+o+")than mesh ("+i+")");if(e.byteLength<15+4*o*l)throw new Error("CURV file smaller than specified");const c=new Float32Array(l*o);let h=15;for(let m=0;m<l*o;m++)c[m]=r.getFloat32(h,!1),h+=4;let d=c[0],f=c[0];for(let m=0;m<c.length;m++)d=Math.min(d,c[m]),f=Math.max(f,c[m]);const u=1/(f-d);for(let m=0;m<c.length;m++)c[m]=1-(c[m]-d)*u;return c}static readANNOT(e,i,r=!1){const s=new DataView(e),n=s.getUint32(0,!1),a=this.decimateLayerVertices(n,i);if(i!==a)throw new Error("ANNOT file has different number of vertices than mesh");if(e.byteLength<4+8*n)throw new Error("ANNOT file smaller than specified");let o=0;const l=new Uint32Array(n);for(let v=0;v<n;v++){const b=s.getUint32(o+=4,!1);l[b]=s.getUint32(o+=4,!1)}if(!r)return l;let c=0;try{c=s.getInt32(o+=4,!1)}catch{return l}if(c!==1||s.getInt32(o+=4,!1)>0)return l;const f=s.getInt32(o+=4,!1),u=s.getInt32(o+=4,!1);o+=u;const m=s.getInt32(o+=4,!1);if(m<1)return l;const p={R:Array(f).fill(0),G:Array(f).fill(0),B:Array(f).fill(0),A:Array(f).fill(0),I:Array(f).fill(0),labels:Array(f).fill("")};for(let v=0;v<m;v++){const b=s.getInt32(o+=4,!1),w=s.getInt32(o+=4,!1);o+=4;let C="";for(let S=0;S<w;S++){const U=s.getUint8(o++);if(U===0)break;C+=String.fromCharCode(U)}o-=4;const M=s.getInt32(o+=4,!1),T=s.getInt32(o+=4,!1),E=s.getInt32(o+=4,!1),I=s.getInt32(o+=4,!1);if(b<0||b>=f){F.warn("annot entry out of range");continue}p.R[b]=M,p.G[b]=T,p.B[b]=E,p.A[b]=I,p.I[b]=(I<<24)+(E<<16)+(T<<8)+M,p.labels[b]=C}let g=!0;for(let v=0;v<f;v++)p.A[v]>0&&(g=!1);if(g)for(let v=0;v<f;v++)p.A[v]=255;const x=new Float32Array(n);x.fill(-1);let A=0;for(let v=0;v<i;v++){const b=l[v];for(let w=0;w<f;w++)if(p.I[w]===b){x[v]=w;break}x[v]<0&&(A++,x[v]=0)}A>0&&F.error(`annot vertex colors do not match ${A} of ${n} vertices.`);for(let v=0;v<f;v++)p.I[v]=v;const y=re.makeLabelLut(p);return{scalars:x,colormapLabel:y}}static readNV(e){const i=e.byteLength,r=new Uint8Array(e);let s=0;function n(){for(;s<i&&r[s]===10;)s++;const f=s;for(;s<i&&r[s]!==10;)s++;return s++,s-f<1?"":new TextDecoder().decode(e.slice(f,s-1))}let a=0,o=0,l=0,c=0,h,d;for(;s<i;){const f=n();if(f.startsWith("#"))continue;const u=f.trim().split(/\s+/);if(a<1){a=parseInt(u[0]),h=new Float32Array(a*3);continue}if(l<a*3){h[l]=parseFloat(u[0]),h[l+1]=parseFloat(u[1]),h[l+2]=parseFloat(u[2]),l+=3;continue}if(o<1){o=parseInt(u[0]),d=new Uint32Array(o*3);continue}if(c>=o*3)break;d[c+2]=parseInt(u[0])-1,d[c+1]=parseInt(u[1])-1,d[c+0]=parseInt(u[2])-1,c+=3}return{positions:h,indices:d}}static readASC(e){const i=e.byteLength,r=new Uint8Array(e);let s=0;function n(){for(;s<i&&r[s]===10;)s++;const u=s;for(;s<i&&r[s]!==10;)s++;return s++,s-u<1?"":new TextDecoder().decode(e.slice(u,s-1))}let a=n();a.startsWith("#!ascii")||F.warn("Invalid ASC mesh"),a=n();let o=a.trim().split(/\s+/);const l=parseInt(o[0]),c=parseInt(o[1]),h=new Float32Array(l*3);let d=0;for(let u=0;u<l;u++)a=n(),o=a.trim().split(/\s+/),h[d]=parseFloat(o[0]),h[d+1]=parseFloat(o[1]),h[d+2]=parseFloat(o[2]),d+=3;const f=new Uint32Array(c*3);d=0;for(let u=0;u<c;u++)a=n(),o=a.trim().split(/\s+/),f[d]=parseInt(o[0]),f[d+1]=parseInt(o[1]),f[d+2]=parseInt(o[2]),d+=3;return{positions:h,indices:f}}static readVTK(e){const i=e.byteLength;if(i<20)throw new Error("File too small to be VTK: bytes = "+e.byteLength);const r=new Uint8Array(e);let s=0;function n(p=!0){if(p)for(;s<i&&r[s]===10;)s++;const g=s;for(;s<i&&r[s]!==10;)s++;return s++,s-g<1?"":new TextDecoder().decode(e.slice(g,s-1))}let a=n();if(!a.startsWith("# vtk DataFile"))throw new Error("Invalid VTK mesh");if(a=n(!1),a=n(),a.startsWith("ASCII"))return fe.readTxtVTK(e);if(!a.startsWith("BINARY"))throw new Error("Invalid VTK image, expected ASCII or BINARY "+a);if(a=n(),!a.includes("POLYDATA"))throw new Error("Only able to read VTK POLYDATA "+a);a=n(),(!a.includes("POINTS")||!a.includes("double")&&!a.includes("float"))&&F.warn("Only able to read VTK float or double POINTS"+a);const o=a.includes("double");let l=a.trim().split(/\s+/);const h=parseInt(l[1])*3,d=new Float32Array(h),f=new DataView(e);if(o)for(let p=0;p<h;p++)d[p]=f.getFloat64(s,!1),s+=8;else for(let p=0;p<h;p++)d[p]=f.getFloat32(s,!1),s+=4;a=n(),l=a.trim().split(/\s+/);const u=[];if(l[0].includes("LINES")){const p=parseInt(l[1]),g=s;if(a=n(),a.startsWith("OFFSETS")){let v=!1;a.includes("int64")&&(v=!0);const b=new Uint32Array(p);if(v){let C=!1;for(let M=0;M<p;M++){let T=f.getInt32(s,!1);T!==0&&(C=!0),s+=4,T=f.getInt32(s,!1),s+=4,b[M]=T}C&&F.warn("int32 overflow: JavaScript does not support int64")}else for(let C=0;C<p;C++){const M=f.getInt32(s,!1);s+=4,b[C]=M}return{pts:d,offsetPt0:b}}s=g;let x=0;const A=[],y=[];A.push(x);for(let v=0;v<p;v++){const b=f.getInt32(s,!1);s+=4,x+=b,A.push(x);for(let w=0;w<b;w++){const C=f.getInt32(s,!1)*3;s+=4,y.push(d[C+0]),y.push(d[C+1]),y.push(d[C+2])}}return{pts:Float32Array.from(y),offsetPt0:Uint32Array.from(A)}}else if(l[0].includes("TRIANGLE_STRIPS")){const p=parseInt(l[1]);for(let g=0;g<p;g++){const x=f.getInt32(s,!1)-2;s+=4;for(let A=0;A<x;A++)A%2?(u.push(f.getInt32(s+8,!1)),u.push(f.getInt32(s+4,!1)),u.push(f.getInt32(s,!1))):(u.push(f.getInt32(s,!1)),u.push(f.getInt32(s+4,!1)),u.push(f.getInt32(s+8,!1))),s+=4;s+=8}}else if(l[0].includes("POLYGONS")){const p=parseInt(l[1]),g=s,x=n();if(x.startsWith("OFFSETS")){let A=x.includes("int64");const y=new Uint32Array(p);let v=!1;for(let M=0;M<p;M++)A&&(f.getInt32(s,!1)!==0&&(v=!0),s+=4),y[M]=f.getInt32(s,!1),s+=4;if(!Number.isSafeInteger(p)||p>=2147483648||v)throw new Error("values exceed 2GB limit");const b=n();if(!b.startsWith("CONNECTIVITY"))throw new Error("Expected CONNECTIVITY after OFFSETS");A=b.includes("int64");const w=y[p-1],C=new Uint32Array(w);for(let M=0;M<w;M++)A&&(s+=4),C[M]=f.getInt32(s,!1),s+=4;for(let M=0;M<p;M++){const T=M===0?0:y[M-1],E=y[M];for(let I=1;I<E-T-1;I++)u.push(C[T]),u.push(C[T+I]),u.push(C[T+I+1])}}else{s=g;for(let A=0;A<p;A++){const y=f.getInt32(s,!1)-2;if(A===0&&y>65535)throw new Error("Invalid VTK binary polygons using little-endian data (MRtrix)");s+=4;const v=f.getInt32(s,!1);s+=4;let b=f.getInt32(s,!1);s+=4;for(let w=0;w<y;w++){const C=f.getInt32(s,!1);s+=4,u.push(v,b,C),b=C}}}}else throw new Error("Unsupported binary VTK datatype "+l[0]);const m=new Uint32Array(u);return{positions:d,indices:m}}static readWRL(e){const i=new TextDecoder("utf-8").decode(e),r=/coord\s+Coordinate\s*\{\s*point\s*\[([\s\S]*?)\]/,s=/coordIndex\s*\[([\s\S]*?)\]/,n=/color\s+Color\s*\{\s*color\s*\[([\s\S]*?)\]/,a=r.exec(i),o=s.exec(i),l=n.exec(i);if(!a||!o)throw new Error("Invalid WRL file: Could not find vertices or indices.");const c=new Float32Array(a[1].trim().split(/[\s,]+/).map(Number));let h=null;if(l){h=new Float32Array(l[1].trim().split(/[\s,]+/).map(Number));const f=c.length/3;h.length!==f*3&&(console.warn(`Unexpected color count: expected ${f*3}, got ${h.length}`),h=null)}const d=new Uint32Array(o[1].trim().split(/[\s,]+/).map(Number).filter(f=>f!==-1));return{positions:c,indices:d,colors:h}}static readDFS(e){const i=new DataView(e),r=i.getUint32(0,!0),s=i.getUint16(4,!0);(r!==1599292996||s!==17740)&&F.warn("Not a little-endian brainsuite DFS mesh");const n=i.getUint32(12,!0),a=i.getUint32(24,!0),o=i.getUint32(28,!0),l=i.getUint32(48,!0);let c=n;const h=new Uint32Array(e,c,a*3);c+=a*3*4;const d=new Float32Array(e,c,o*3);for(let u=0;u<o*3;u+=3){const m=d[u];d[u]=d[u+1],d[u+1]=m}let f;return l>=0&&(f=new Float32Array(e,l,o*3)),{positions:d,indices:h,colors:f}}static async readMZ3(e,i=0){if(e.byteLength<20)throw new Error("File too small to be mz3: bytes = "+e.byteLength);let r=new DataView(e),s=e,n=r.getUint16(0,!0);if(n===35615||n===8075){const T=await H.decompress(new Uint8Array(e));r=new DataView(T.buffer),n=r.getUint16(0,!0),s=T.buffer}const a=r.getUint16(2,!0),o=r.getUint32(4,!0);let l=r.getUint32(8,!0);const c=r.getUint32(12,!0);if(vt.debug("MZ3 magic %d attr %d face %d vert %d skip %d",n,a,o,l,c),n!==23117)throw new Error("Invalid MZ3 file");const h=(a&1)!==0,d=(a&2)!==0,f=(a&4)!==0;let u=(a&8)!==0;const m=(a&16)!==0,p=(a&32)!==0,g=(a&64)!==0;if(vt.debug(`isFace=${h} isVert=${d} isRGBA=${f} isSCALAR=${u} isDOUBLE=${m} isAOMAP=${p} isLOOKUP=${g}`),a>127)throw new Error("Unsupported future version of MZ3 file");let x=4;m&&(x=8);let A=0;if(i>0&&!h&&o<1&&!f&&(u=!0),u){const T=i||l,E=16+c+(h?o*12:0)+(d?T*12:0)+(f?T*4:0),I=Math.floor((s.byteLength-E)/x);l!==i&&I%i===0&&(l=i),A=Math.floor(I/l),A<1&&(F.warn("Corrupt MZ3: file reports NSCALAR but not enough bytes"),u=!1)}if(l<3&&i<3)throw new Error("Not a mesh MZ3 file (maybe scalar)");i>0&&i!==l&&F.warn("Layer has "+l+"vertices, but background mesh has "+i);let y=16+c;const v=new DataView(s);let b=null;if(h){b=new Uint32Array(o*3);for(let T=0;T<o*3;T++)b[T]=v.getUint32(y,!0),y+=4}let w=null;if(d){w=new Float32Array(l*3);for(let T=0;T<l*3;T++)w[T]=v.getFloat32(y,!0),y+=4}let C=null;if(f){C=new Float32Array(l*3);for(let T=0;T<l;T++){for(let E=0;E<3;E++)C[T*3+E]=v.getUint8(y++)/255;y++}}let M=new Float32Array;if(u&&A>0)if(m){const T=new Float64Array(A*l);for(let E=0;E<A*l;E++)T[E]=v.getFloat64(y,!0),y+=8;M=Float32Array.from(T)}else{M=new Float32Array(A*l);for(let T=0;T<A*l;T++)M[T]=v.getFloat32(y,!0),y+=4}if(i>0&&g&&u){const T=new TextDecoder("utf-8"),E=new Uint8Array(s,16,c),I=T.decode(E),S=JSON.parse(I),U=re.makeLabelLut(S);return{scalars:M,colormapLabel:U}}if(i>0&&f&&u){let T=M[0];for(let S=0;S<l;S++)T=Math.max(T,M[S]);const E={R:[],G:[],B:[],A:[],I:[],labels:[]};for(let S=0;S<=T;S++)for(let U=0;U<l;U++)if(S===M[U]){const B=U*3;E.I.push(S),E.R.push(C[B]*255),E.G.push(C[B+1]*255),E.B.push(C[B+2]*255),E.A.push(255),E.labels.push(`${S}`);break}const I=re.makeLabelLut(E);return{scalars:M,colormapLabel:I}}return i>0?{scalars:M}:{positions:w,indices:b,scalars:M,colors:C}}static readPLY(e){const i=e.byteLength,r=new Uint8Array(e);let s=0;function n(){for(;s<i&&r[s]===10;)s++;const R=s;for(;s<i&&r[s]!==10;)s++;return s++,s-R<1?"":new TextDecoder().decode(e.slice(R,s-1))}let a=n();if(!a.startsWith("ply"))throw new Error("Not a valid PLY file");a=n();const o=a.includes("ascii");function l(R){if(R==="char"||R==="uchar"||R==="int8"||R==="uint8")return 1;if(R==="short"||R==="ushort"||R==="int16"||R==="uint16")return 2;if(R==="int"||R==="uint"||R==="int32"||R==="uint32"||R==="float"||R==="float32")return 4;if(R==="double")return 8;throw new Error("Unknown data type: "+R)}const c=a.includes("binary_little_endian");let h=0,d=!1,f=0,u=0,m=0,p=0,g=0,x=0,A=0;const y=[];let v=0,b=-1,w=-1,C=-1,M=!1;for(;s<i&&!a.startsWith("end_header");){if(a=n(),a.startsWith("comment"))continue;let R=a.split(/\s/);if(a.startsWith("element vertex"))for(h=parseInt(R[R.length-1]),a=n(),R=a.split(/\s/),v=0,y.length=0;a.startsWith("property");){const P=R[1],L=R[2];y.push(L),L==="red"?(b=v,M=!0):L==="green"?(w=v,M=!0):L==="blue"&&(C=v,M=!0),L==="x"&&P.startsWith("double")?d=!0:L==="x"&&!P.startsWith("float")&&F.error("Error: expect ply xyz to be float or double: "+a);const N=l(P);f+=N,v+=N,a=n(),R=a.split(/\s/)}if(a.startsWith("element face"))for(A=parseInt(R[R.length-1]),a=n(),R=a.split(/\s/);a.startsWith("property");){if(R[1]==="list")m=l(R[2]),p=l(R[3]),u+=m+3*p;else{const P=l(R[1]);u+=P,p===0&&(g+=P,x++)}a=n(),R=a.split(/\s/)}}if(o){A<1&&F.error(`Malformed ply format: faces ${A} `);const R=new Float32Array(h*3);let P;const L=y.indexOf("x"),N=y.indexOf("y"),Y=y.indexOf("z"),_=y.indexOf("red"),z=y.indexOf("green"),W=y.indexOf("blue");_!==-1&&z!==-1&&W!==-1&&(P=new Float32Array(h*3),M=!0);let K=0;for(let ue=0;ue<h;ue++){a=n();const le=a.split(/\s/),je=L>=0?parseFloat(le[L]):parseFloat(le[0]),at=N>=0?parseFloat(le[N]):parseFloat(le[1]),_e=Y>=0?parseFloat(le[Y]):parseFloat(le[2]);if(R[K]=je,R[K+1]=at,R[K+2]=_e,M&&P){const Fe=_>=0?parseInt(le[_]):0,Gt=z>=0?parseInt(le[z]):0,xa=W>=0?parseInt(le[W]):0,Ci=ue*3;P[Ci]=Fe/255,P[Ci+1]=Gt/255,P[Ci+2]=xa/255}K+=3}let Z=new Uint32Array(A*3),q=0;for(let ue=0;ue<A;ue++){a=n();const le=a.split(/\s/),je=parseInt(le[x])-2;if(je<1)break;if(q+je*3>Z.length){const Fe=new Uint32Array(Z.length+Z.length);Fe.set(Z),Z=Fe.slice()}const at=parseInt(le[x+1]);let _e=parseInt(le[x+2]);for(let Fe=0;Fe<je;Fe++){const Gt=parseInt(le[x+3+Fe]);Z[q+0]=at,Z[q+1]=_e,Z[q+2]=Gt,_e=Gt,q+=3}}Z.length!==q&&(Z=Z.slice(0,q));const te={positions:R,indices:Z};return M&&(te.colors=typeof P<"u"?P:void 0),te}(f<12||m<1||p<1||A<1)&&F.warn(`Malformed ply format: stride ${f} count ${m} iBytes ${p} iStrideBytes ${u} iPadBytes ${g} faces ${A}`);const T=new DataView(e);let E,I;if(M&&(I=new Float32Array(h*3)),s%4===0&&f===12&&c)E=new Float32Array(e,s,h*3),s+=h*f;else{E=new Float32Array(h*3);let R=0;for(let P=0;P<h;P++){if(d?(E[R]=T.getFloat64(s,c),E[R+1]=T.getFloat64(s+8,c),E[R+2]=T.getFloat64(s+16,c)):(E[R]=T.getFloat32(s,c),E[R+1]=T.getFloat32(s+4,c),E[R+2]=T.getFloat32(s+8,c)),M&&I){const L=s,N=b>=0?T.getUint8(L+b):0,Y=w>=0?T.getUint8(L+w):0,_=C>=0?T.getUint8(L+C):0,z=P*3;I[z]=N/255,I[z+1]=Y/255,I[z+2]=_/255}R+=3,s+=f}}const S=new Uint32Array(A*3);let U=!0,B=0;if(m===1&&p===4&&u===13)for(let R=0;R<A;R++){const P=T.getUint8(s);s+=m,P!==3&&(U=!1),S[B]=T.getUint32(s,c),s+=4,S[B+1]=T.getUint32(s,c),s+=4,S[B+2]=T.getUint32(s,c),s+=4,B+=3}else{let R=s;for(let P=0;P<A;P++){s=R+g;let L=0;m===1?L=T.getUint8(s):m===2?L=T.getUint16(s,c):m===4&&(L=T.getUint32(s,c)),s+=m,L!==3&&(U=!1);for(let N=0;N<3;N++)p===1?S[B]=T.getUint8(s):p===2?S[B]=T.getUint16(s,c):p===4&&(S[B]=T.getUint32(s,c)),B++,s+=p;R+=u}}U||F.warn("Only able to read PLY meshes limited to triangles.");const V={positions:E,indices:S};return M&&typeof I<"u"&&(V.colors=I),V}static readICO(e){const s=new TextDecoder("utf-8").decode(e).split(`
+`);let n=s[0].trim().split(/\s+/);n.length>1&&F.warn("This is not a valid FreeSurfer ICO/TRI mesh.");const a=parseInt(n[0]),o=new Float32Array(a*3);let l=1;for(let d=0;d<a;d++){const f=s[l].trim().split(/\s+/);l++;let u=parseInt(f[0])-1;const m=parseFloat(f[1]),p=parseFloat(f[2]),g=parseFloat(f[3]);if(u<0||u>=a){F.error("ICO vertices corrupted");break}u*=3,o[u]=m,o[u+1]=p,o[u+2]=g}n=s[l].trim().split(/\s+/),l++;const c=parseInt(n[0]),h=new Uint32Array(c*3);for(let d=0;d<c;d++){const f=s[l].trim().split(/\s+/);l++;let u=parseInt(f[0])-1;const m=parseInt(f[1])-1,p=parseInt(f[2])-1,g=parseInt(f[3])-1;if(u<0||u>=c){F.error("ICO indices corrupted");break}u*=3,h[u]=m,h[u+1]=p,h[u+2]=g}for(let d=0;d<h.length;d+=3){const f=h[d];h[d]=h[d+1],h[d+1]=f}return{positions:o,indices:h}}static readGEO(e,i=!1){const n=new TextDecoder("utf-8").decode(e).split(`
+`),a=n[0].trim().split(/\s+/),o=parseInt(a[0]);let l=parseInt(a[1]),c=parseInt(a[2]);const h=parseInt(a[3]);(o>1||h!==c*3)&&F.warn("Multi-part BYU/GEO header or not a triangular mesh.");const d=[];l*=3;let f=0,u=2;for(;f<l;){const A=n[u].trim().split(/\s+/);u++;for(let y=0;y<A.length&&(d.push(parseFloat(A[y])),f++,!(f>=l));y++);}const m=[];c*=3;let p=0;for(;p<c;){const A=n[u].trim().split(/\s+/);u++;for(let y=0;y<A.length&&(m.push(Math.abs(parseInt(A[y]))-1),p++,!(p>=c));y++);}if(i)for(let A=0;A<m.length;A+=3){const y=m[A];m[A]=m[A+1],m[A+1]=y}const g=new Float32Array(d),x=new Uint32Array(m);return{positions:g,indices:x}}static readOFF(e){const s=new TextDecoder("utf-8").decode(e).split(`
+`),n=[],a=[];let o=0;s[o].includes("OFF")?o++:F.warn("File does not start with OFF");let l=s[o].trim().split(/\s+/);const c=parseInt(l[0]),h=parseInt(l[1]);o++;for(let u=0;u<c;u++)l=s[o].trim().split(/\s+/),n.push(parseFloat(l[0])),n.push(parseFloat(l[1])),n.push(parseFloat(l[2])),o++;for(let u=0;u<h;u++)l=s[o].trim().split(/\s+/),parseInt(l[0])!==3&&F.warn("Only able to read OFF files with triangular meshes"),a.push(parseInt(l[1])),a.push(parseInt(l[2])),a.push(parseInt(l[3])),o++;const d=new Float32Array(n),f=new Uint32Array(a);return{positions:d,indices:f}}static readOBJMNI(e){const s=new TextDecoder("utf-8").decode(e).trim().split(/\s*,\s*|\s+/);(s.length<1||s[0]!=="P")&&F.warn("This is not a valid MNI OBJ mesh.");let n=6;const a=parseInt(s[n++]),o=a*3,l=new Float32Array(o);for(let m=0;m<o;m++)l[m]=parseFloat(s[n++]);n+=o;const c=parseInt(s[n++]),h=parseInt(s[n++]);(c<1||h<0||h>2)&&F.warn("This is not a valid MNI OBJ mesh.");let d=1;h===1?d=c:h===1&&(d=a),n+=d*4,n+=c;const f=c*3,u=new Uint32Array(f);for(let m=0;m<f;m++)u[m]=parseInt(s[n++]);return{positions:l,indices:u}}static async readOBJ(e){const i=new Uint8Array(e,0,2);i[0]===31&&i[1]===139&&(e=await H.decompressToBuffer(new Uint8Array(e)));const s=new TextDecoder("utf-8").decode(e);if(s[0]==="P")return this.readOBJMNI(e);const n=s.split(`
+`),a=n.length,o=[],l=[];for(let u=0;u<a;u++){const m=n[u];if(m[0]==="v"&&m[1]===" "){const p=m.trim().split(/\s+/);o.push(parseFloat(p[1])),o.push(parseFloat(p[2])),o.push(parseFloat(p[3]))}if(m[0]==="f"){const p=m.trim().split(/\s+/),g=p.length-3;if(g<1)break;let x=p[1].split("/");const A=parseInt(x[0])-1;x=p[2].split("/");let y=parseInt(x[0])-1;for(let v=0;v<g;v++){x=p[3+v].split("/");const b=parseInt(x[0])-1;l.push(A),l.push(y),l.push(b),y=b}}}const c=new Float32Array(o),h=new Uint32Array(l);let d=h[0],f=h[0];for(let u=1;u<h.length;u++)h[u]<d&&(d=h[u]),h[u]>f&&(f=h[u]);if(f-d+1>c.length/3)throw new Error("Not a valid OBJ file");for(let u=0;u<h.length;u++)h[u]-=d;return{positions:c,indices:h}}static readFreeSurfer(e){const i=new Uint8Array(e);if(i[0]===35&&i[1]===33&&i[2]===97)return fe.readASC(e);const r=new DataView(e),s=r.getUint32(0,!1),n=r.getUint32(4,!1);(s!==4294966883||n!==1919246708)&&vt.debug("Unable to recognize file type: does not appear to be FreeSurfer format.");let a=0;for(;r.getUint8(a)!==10;)a++;a+=2;let o=r.getUint32(a,!1);a+=4;let l=r.getUint32(a,!1);a+=4,o*=3;const c=new Float32Array(o);for(let u=0;u<o;u++)c[u]=r.getFloat32(a,!1),a+=4;l*=3;const h=new Uint32Array(l);for(let u=0;u<l;u++)h[u]=r.getUint32(a,!1),a+=4;const d=r.getUint32(a,!1);a+=4;let f=d===20;if(!f){const u=r.getUint32(a,!1);a+=4;const m=r.getUint32(a,!1);a+=4,f=d===2&&u===0&&m===20}if(!f)F.warn("Unknown FreeSurfer Mesh extension code.");else{const m=new TextDecoder().decode(e.slice(a)).trim().split(`
+`);for(let p=0;p<m.length;p++){if(!m[p].startsWith("cras"))continue;const x=m[p].split("=")[1].trim().split(" ").map(Number),A=Math.floor(c.length/3);let y=0;for(let v=0;v<A;v++)c[y]+=x[0],y++,c[y]+=x[1],y++,c[y]+=x[2],y++}}return{positions:c,indices:h}}static async readSRF(e){const i=new Uint8Array(e);if(i[0]===35&&i[1]===33&&i[2]===97)return fe.readASC(e);i[0]===31&&i[1]===139&&(e=(await H.decompress(new Uint8Array(e))).buffer);const r=new DataView(e),s=r.getFloat32(0,!0),n=r.getUint32(8,!0),a=r.getUint32(12,!0),o=r.getFloat32(16,!0),l=r.getFloat32(20,!0),c=r.getFloat32(24,!0),h=new Float32Array(n*3);let d=28,f=1;for(let w=0;w<n;w++)h[f]=-r.getFloat32(d,!0)+o,f+=3,d+=4;f=2;for(let w=0;w<n;w++)h[f]=-r.getFloat32(d,!0)+l,f+=3,d+=4;f=0;for(let w=0;w<n;w++)h[f]=-r.getFloat32(d,!0)+c,f+=3,d+=4;d=28+24*n;const u=r.getFloat32(d,!0),m=r.getFloat32(d+4,!0),p=r.getFloat32(d+8,!0),g=r.getFloat32(d+16,!0),x=r.getFloat32(d+20,!0),A=r.getFloat32(d+24,!0);d+=32;const y=new Float32Array(n*3),v=new Uint32Array(e,d,n);f=0;for(let w=0;w<n;w++){const C=v[w];C>1056964608&&(y[f+0]=(C>>16&255)/255,y[f+1]=(C>>8&255)/255,y[f+2]=(C&255)/255),C===0&&(y[f+0]=u,y[f+1]=m,y[f+2]=p),C===1&&(y[f+0]=g,y[f+1]=x,y[f+2]=A),f+=3}d+=n*4;for(let w=0;w<n;w++){const C=r.getUint32(d,!0);d+=4+4*C}const b=new Uint32Array(a*3);for(let w=0;w<a*3;w++)b[w]=r.getInt32(d,!0),d+=4;return s!==4&&F.warn("Not valid SRF"),{positions:h,indices:b,colors:y}}static readTxtSTL(e){const s=new TextDecoder("utf-8").decode(e).split(`
+`);if(!s[0].startsWith("solid"))throw new Error("Not a valid STL file");const n=[];for(let c=1;c<s.length;c++){if(!s[c].includes("vertex"))continue;const h=s[c].trim().split(/\s+/);for(let d=1;d<h.length;d++)n.push(parseFloat(h[d]))}const a=Math.floor(n.length/3);if(a*3!==n.length)throw new Error("Unable to parse ASCII STL file.");const o=new Float32Array(n),l=new Uint32Array(a);for(let c=0;c<a;c++)l[c]=c;return{positions:o,indices:l}}static readSTL(e){if(e.byteLength<134)throw new Error("File too small to be STL: bytes = "+e.byteLength);const i=new DataView(e);if(i.getUint32(0,!0)===1768714099)return fe.readTxtSTL(e);const s=i.getUint32(80,!0),n=3*s;if(e.byteLength<84+s*50)throw new Error("STL file too small to store triangles = "+s);const a=new Uint32Array(n),o=new Float32Array(n*3);let l=96,c=0;for(let h=0;h<s;h++){for(let d=0;d<9;d++)o[c]=i.getFloat32(l,!0),c+=1,l+=4;l+=14}for(let h=0;h<n;h++)a[h]=h;return{positions:o,indices:a}}static decimateLayerVertices(e,i){if(e%i===0)return e;const r=12,s=Math.round(Math.log((e-2)/(r-2))/Math.log(4)),n=Math.round(Math.log((i-2)/(r-2))/Math.log(4)),a=Math.pow(4,s)*(r-2)+2,o=Math.pow(4,n)*(r-2)+2;return a!==e||o!==i?e:i}static async readNII2(e,i=0,r=""){let s=new Float32Array;const n=e.byteLength;let a=!0;const o=new DataView(e);let l=o.getUint16(0,a);if(l===469893120&&(a=!1,l=o.getUint16(0,a)),l!==540)throw new Error("Not a valid NIfTI-2 dataset");const c=Number(o.getBigInt64(168,a)),h=o.getFloat64(176,a),d=o.getFloat64(184,a);(h!==1||d!==0)&&F.warn("ignoring scale slope and intercept");const f=o.getUint32(504,a),u=o.getUint16(12,a);if(u!==2&&u!==4&&u!==8&&u!==16)throw new Error("Unsupported NIfTI datatype "+u);let m=1;const p=[1,1,1,1,1,1,1,1];for(let g=1;g<8;g++)p[g]=Math.max(Number(o.getBigInt64(16+g*8,a)),1),m*=p[g];if(f>=3e3&&f<=3099&&c>580){let g=function(){for(;T<n&&M[T]===10;)T++;const R=T;for(;T<n&&M[T]!==10;)T++;return T++,T-R<1?"":new TextDecoder().decode(e.slice(R,T-1)).trim()},x=function(){let R=g();if(!R.startsWith("<")||R.endsWith(">"))return R;for(;T<n&&!R.endsWith(">");)R+=g();return R},A=function(R,P=!1){const L=E.indexOf(R);if(L<0)return 1;const N=E.indexOf('"',L)+1,Y=E.indexOf('"',N),_=E.slice(N,Y);return P?_:parseInt(_)},y=0,v=0,b=0,w="",C=new Uint32Array;const M=new Uint8Array(e);let T=552,E;const I=p[5],S=new Float32Array(i*I);for(;T<n&&(E=x(),!E.includes("</CIFTI>"));)if(E.includes("<BrainModel")){const R=A("SurfaceNumberOfVertices="),P=A("BrainStructure=",!0).toUpperCase();if(R%i!==0)continue;let L=!1;if(r.includes("CORTEX")&&P.includes("CORTEX")&&(L=!0),!L||(L=!1,r.includes("LEFT")&&P.includes("LEFT")&&(L=!0),r.includes("RIGHT")&&P.includes("RIGHT")&&(L=!0),!L))continue;if(b=R,y=A("IndexOffset="),v=A("IndexCount="),w=P,E.includes("<VertexIndices>")||(E=x()),!E.startsWith("<VertexIndices>")||!E.endsWith("</VertexIndices>"))return F.warn("Unable to find CIfTI <VertexIndices>"),S;E=E.slice(15,-16);const N=E.trim().split(/\s+/);N.length<v&&F.error("Error parsing VertexIndices"),C=new Uint32Array(v);for(let Y=0;Y<v;Y++)C[Y]=parseInt(N[Y])}if(b===0||C.length===0)return F.warn("Unable to find CIfTI structure that matches the mesh."),S;if(u!==16)return F.warn("Only able to read float32 CIfTI (only known datatype)."),S;const U=new Float32Array(v*I),B=c+I*y*4;for(let R=0;R<v*I;R++)U[R]=o.getFloat32(B+R*4,a);let V=0;for(let R=0;R<v;R++)for(let P=0;P<I;P++)S[C[R]+P*i]=U[V],V++;return F.debug("CIfTI diagnostics",b,w,y,v,y,r),S}if(m=this.decimateLayerVertices(m,i),m%i!==0)throw new Error("Vertices in layer ("+m+") is not a multiple of number of vertices ("+i+")");if(a)u===16?s=new Float32Array(e,c,m):u===8?s=new Int32Array(e,c,m):u===4&&(s=new Int16Array(e,c,m));else if(u===16){s=new Float32Array(m);for(let g=0;g<m;g++)s[g]=o.getFloat32(c+g*4,a)}else if(u===8){s=new Int32Array(m);for(let g=0;g<m;g++)s[g]=o.getInt32(c+g*4,a)}else if(u===4){s=new Int16Array(m);for(let g=0;g<m;g++)s[g]=o.getInt16(c+g*2,a)}return u===2&&(s=new Uint8Array(e,c,m)),s}static async readNII(e,i,r=""){const s=i.length/3;let n=new Float32Array,a=!0,o=new DataView(e),l=o.getUint16(0,a);if(l===540||l===469893120)return fe.readNII2(e,s,r);if(l===23553&&(a=!1,l=o.getUint16(0,a)),l!==348){const w=await H.decompress(new Uint8Array(e));if(o=new DataView(w.buffer),e=w.buffer,l=o.getUint16(0,a),l===540||l===469893120)return fe.readNII2(e,s,r);l===23553&&(a=!1,l=o.getUint16(0,a))}l!==348&&F.error("Not a valid NIfTI image.");const c=o.getFloat32(108,a),h=o.getFloat32(112,a),d=o.getFloat32(116,a),f=o.getUint16(252,a),u=o.getUint16(254,a),m=o.getUint16(70,a);if(m!==2&&m!==4&&m!==8&&m!==16)throw new Error("Unsupported NIfTI datatype "+m);const p=J();for(let w=0;w<12;w++)p[w]=o.getFloat32(280+w*4,a);let g=1;const x=new Array(8);for(let w=0;w<8;w++)x[w]=o.getUint16(40+w*2,a),!(w<1)&&(g*=x[w]||1);let A=!1,y=this.decimateLayerVertices(g,s);if(y%s!==0)if(x[0]>=3&&x[1]>1&&x[2]>1&&x[3]>1)A=!0,y=x[1]*x[2]*x[3];else throw new Error("Voxels in layer ("+g+") is not a multiple of number of vertices ("+s+")");if(g=y,a)m===16?n=new Float32Array(e,c,g):m===8?n=new Int32Array(e,c,g):m===4&&(n=new Int16Array(e,c,g));else if(m===16){n=new Float32Array(g);for(let w=0;w<g;w++)n[w]=o.getFloat32(c+w*4,a)}else if(m===8){n=new Int32Array(g);for(let w=0;w<g;w++)n[w]=o.getInt32(c+w*4,a)}else if(m===4){n=new Int16Array(g);for(let w=0;w<g;w++)n[w]=o.getInt16(c+w*2,a)}if(m===2&&(n=new Uint8Array(e,c,g)),Number.isFinite(h)&&Number.isFinite(d)&&h!==0&&(h!==1||d!==0)){const w=new Float32Array(g);for(let C=0;C<g;C++)w[C]=n[C]*h+d;n=w}let v=n[0],b=v;for(let w=0;w<g;w++)isNaN(n[w])&&(n[w]=0),v=Math.min(v,n[w]),b=Math.max(b,n[w]);if(F.debug(`Layer Range ${v}..${b} slope ${h} inter ${d}`),A){let w=function(P,L){const N=[0,0,0];return N[0]=L[0]*P[0]+L[1]*P[1]+L[2]*P[2]+L[3],N[1]=L[4]*P[0]+L[5]*P[1]+L[6]*P[2]+L[7],N[2]=L[8]*P[0]+L[9]*P[1]+L[10]*P[2]+L[11],N};const C=new Float32Array(s);F.warn("Sampling voxel intensities at mesh vertices (assumes precise alignment)."),(f>u||u<=0)&&F.warn(`Requires valid sform (sform_code = ${u})`);const M=J();Se(M,p);const T=x[1],E=x[2],I=x[3],S=T*E;let U=0,B=0,V=0;for(;B<s;){const P=[i[U],i[U+1],i[U+2]],L=w(P,M);U+=3,B+=1;const N=Math.floor(L[0]),Y=Math.floor(L[1]),_=Math.floor(L[2]),z=Math.ceil(L[0]),W=Math.ceil(L[1]),K=Math.ceil(L[2]);if(N<0||z>=T||Y<0||W>=E||_<0||K>=I)continue;const Z=N+Y*T+_*S,q=new Float32Array(8);q[0]=n[Z],q[1]=n[Z+1],q[2]=n[Z+T],q[3]=n[Z+T+1],q[4]=n[Z+S],q[5]=n[Z+S+1],q[6]=n[Z+S+T],q[7]=n[Z+S+T+1];let te=q[0],ue=te;for(let le=1;le<8;le++)te=Math.max(te,q[le]),ue=Math.min(ue,q[le]);Math.abs(ue)>te&&(te=ue),C[B-1]=te,V++}const R=V/s;R<.1&&F.warn(`${V} of ${s} vertices in range (${(R*100).toFixed(1)}%)`),n=C}return n}static async readMGH(e,i=0,r=!1){let s=new DataView(e),n=e;if(s.getUint8(0)===31&&s.getUint8(1)===139){const C=await H.decompress(new Uint8Array(e));n=new ArrayBuffer(C.byteLength),new Uint8Array(n).set(new Uint8Array(C)),s=new DataView(C.buffer)}const a=s.getInt32(0,!1),o=Math.max(1,s.getInt32(4,!1)),l=Math.max(1,s.getInt32(8,!1)),c=Math.max(1,s.getInt32(12,!1)),h=Math.max(1,s.getInt32(16,!1)),d=s.getInt32(20,!1);let f=284;const u=!1;(a!==1||d<0||d>4)&&F.warn("Not a valid MGH file");let m=o*l*c*h,p=[];if(m=this.decimateLayerVertices(m,i),m%i!==0)return F.warn("Vertices in layer ("+m+") is not a multiple of number of vertices ("+i+")"),p;if(d===3){p=new Float32Array(m);for(let C=0;C<m;C++)p[C]=s.getFloat32(f+C*4,u)}else if(d===1){p=new Int32Array(m);for(let C=0;C<m;C++)p[C]=s.getInt32(f+C*4,u)}else if(d===4){p=new Int16Array(m);for(let C=0;C<m;C++)p[C]=s.getInt16(f+C*2,u)}else d===0&&(p=new Uint8Array(e,f,m));if(!r)return p;let g=4;d===4&&(g=2),d===0&&(g=1),f+=g*m,f+=16;const x=1,A=2,y=20,v=30,b=n.byteLength;let w;for(;f<b-8;){const C=s.getInt32(f+=4,u);let M=0;switch(C){case v:M=s.getInt32(f+=4,u)-1;break;case y:case A:M=0;break;case x:M=0;{let T=s.getInt32(f+=4,u);if(T>0)return F.warn("unsupported CTABreadFromBinaryV1"),p;if(T=-T,T!==2)return F.warn("CTABreadFromBinary: unknown version"),p;const E=s.getInt32(f+=4,u);if(E<0)return F.warn("CTABreadFromBinaryV2: nentries was ",E),p;const I=s.getInt32(f+=4,u);f+=I;const S=s.getInt32(f+=4,u);if(S<0)return p;const U={R:[],G:[],B:[],A:[],I:[],labels:[]};for(let B=0;B<S;B++){const V=s.getInt32(f+=4,u),R=s.getInt32(f+=4,u);let P=f+4,L="";for(let W=0;W<R;W++){const K=s.getUint8(P++);if(K===0)break;L+=String.fromCharCode(K)}f+=R;const N=s.getInt32(f+=4,u),Y=s.getInt32(f+=4,u),_=s.getInt32(f+=4,u),z=255-s.getInt32(f+=4,u);U.I.push(V),U.R.push(N),U.G.push(Y),U.B.push(_),U.A.push(z),U.labels.push(L)}w=re.makeLabelLut(U)}break;default:M=s.getInt32(f+=8,u)}f+=M}return{scalars:p,colormapLabel:w}}static readX3D(e){const i=e.byteLength;if(i<20)throw new Error("File too small to be X3D: bytes = "+i);const r=new Uint8Array(e);let s=0;function n(){for(;s<i&&r[s]!==60;)s++;const y=s;for(;s<i&&r[s]!==62;)s++;const v=s;return new TextDecoder().decode(e.slice(y,v+1)).trim()}let a=n();function o(y){const v=a.indexOf(y+"=");if(v<0)return"";const b=a[v+y.length+1],w=a.indexOf(b,v)+1,C=a.indexOf(b,w);return a.slice(w,C)}function l(y){const v=a.indexOf(y+"=");if(v<0)return 1;const b=a[v+y.length+1],w=a.indexOf(b,v)+1,C=a.indexOf(b,w);let M=a.slice(w,C).trim();M=M.replace(/,\s*$/,"");const T=M.trim().split(/\s*,\s*|\s+/);if(T.length<2)return parseFloat(M);let E=new Array(T.length),I=0;for(let S=0;S<T.length;S++){const U=parseFloat(T[S]);isFinite(U)&&(E[I]=U,I++)}return E=E.slice(0,I),E}a.includes("xml version")||F.warn("Not a X3D image");let c=[],h=[],d=[],f=[],u=[0,0,0,0],m=[0,0,0,0],p=[255,255,255,255],g=[255,255,255,255];const x={};function A(){if(!a.endsWith("/>"))if(a.startsWith("<Appearance>"))for(;s<i&&!a.endsWith("</Appearance>");)a+=n();else for(;s<i&&!a.endsWith("/>");)a+=n();const y=o("USE");if(y.length>1){y in x?p=x[y]:F.warn("Unable to find DEF for "+y);return}const v=l("diffuseColor");if(v.length<3)return;p[0]=Math.round(v[0]*255),p[1]=Math.round(v[1]*255),p[2]=Math.round(v[2]*255);const b=o("DEF");b.length<1||(x[b]=p)}for(;s<i;)if(a=n(),p=g.slice(),a.startsWith("<Transform")&&(u=l("translation"),m=l("rotation")),a.startsWith("<Appearance")&&(A(),g=p.slice()),a.startsWith("<Shape")){let y=1,v=1,b=[],w=[];for(;s<i&&(a=n(),a.startsWith("<Appearance")&&A(),!a.startsWith("</Shape"));){if(a.startsWith("<Sphere")&&(y=l("radius"),v=-1),a.startsWith("<Cylinder")&&(y=l("radius"),v=l("height")),a.startsWith("<IndexedFaceSet")&&(v=-2,b=l("coordIndex")),a.startsWith("<IndexedTriangleSet")&&(v=-7,b=l("index")),a.startsWith("<IndexedTriangleStripSet")&&(v=-3,b=l("index")),a.startsWith("<Coordinate")){w=l("point");const C=w.length%3;C!==0&&(w=w.slice(0,-C))}a.startsWith("<Color")&&(f=l("color")),a.startsWith("<Box")&&(v=-4,F.warn("Unsupported x3d shape: Box")),a.startsWith("<Cone")&&(v=-5,F.warn("Unsupported x3d shape: Cone")),a.startsWith("<ElevationGrid")&&(v=-6,F.warn("Unsupported x3d shape: ElevationGrid"))}if(!(v<-3&&v!==-7))if(v<-1){if(b.length<1||w.length<3||w.length===void 0){F.warn("Indexed mesh must specify indices and points");break}const C=Math.floor(c.length/3);let M=2;if(v===-7)h=[...h,...b];else if(v===-2){let I=0;for(;M<b.length;)b[M]>=0?(h.push(b[I]+C),h.push(b[M-1]+C),h.push(b[M-0]+C),M+=1):(M+=3,I=M-2)}else for(;M<b.length;)b[M]>=0?(h.push(b[M-2]+C),h.push(b[M-1]+C),h.push(b[M-0]+C),M+=1):M+=3;c=[...c,...w];const T=Math.floor(w.length/3),E=Array(T).fill(p).flat();if(f.length===T*3){let I=0,S=0;for(let U=0;U<T;U++){for(let B=0;B<3;B++)E[S]=Math.round(f[I]*255),I++,S++;S++}}d=[...d,...E]}else if(v<0)st.makeColoredSphere(c,h,d,y,u,p);else{const C=J();Ma(C,m[3],[m[0],m[1],m[2]]);const M=ae(0,-v*.5,0,1),T=ae(0,+v*.5,0,1);ve(M,M,C),ve(T,T,C),Zr(M,M,u),Zr(T,T,u);const E=k(M[0],M[1],M[2]),I=k(T[0],T[1],T[2]);st.makeColoredCylinder(c,h,d,E,I,y,p)}}return{positions:Float32Array.from(c),indices:Uint32Array.from(h),rgba255:Uint8Array.from(d)}}static async readGII(e,i=0){let r=e.byteLength;if(r<20)throw new Error("File too small to be GII: bytes = "+r);let s=new TextDecoder("ascii").decode(e);if(s[0].charCodeAt(0)===31){const S=await H.decompress(new Uint8Array(e));e=S.buffer,s=new TextDecoder("ascii").decode(S.buffer)}let n=0;function a(){let S=!0,U=n;for(;S;){for(;n<r&&s[n]!=="<";)n++;for(U=n;n<r&&s[n]!==">";)n++;if(S=s[n-1]==="/",U+1<r&&s[U+1]==="/"&&(n+=1,S=!0),n>=r)break}const B=new TextDecoder().decode(e.slice(U+1,n)).trim(),V=B.split(" ")[0].trim(),R=n;let P=n,L=n;if(s[U+1]!=="?"&&s[U+1]!=="!"){const N="</"+V+">";P=s.indexOf(N,R),L=P+N.length-1}return{name:B,startPos:U,contentStartPos:R,contentEndPos:P,endPos:L}}let o=a();if(!o.name.startsWith("?xml"))throw new Error("readGII: Invalid XML file");for(;!o.name.startsWith("GIFTI")&&o.endPos<r;)o=a();if(!o.name.startsWith("GIFTI")||o.contentStartPos===o.contentEndPos)throw new Error("readGII: XML file does not include GIFTI tag");r=o.contentEndPos;let l=new Float32Array,c=new Uint32Array,h=new Float32Array,d="",f=!1,u=!1,m=!1,p=!1,g=[1,1,1];const x=[0,0,0];let A=0,y=!1,v=!1,b=0,w=!1;o.endPos=o.contentStartPos;let C="";function M(S,U=!1){const B=C.indexOf(S);if(B<0)return 1;const V=C.indexOf('"',B)+1,R=C.indexOf('"',V),P=C.slice(V,R);return U?parseFloat(P):parseInt(P)}function T(S){const U=C.indexOf(S);if(U<0)return"";const B=U+S.length,V=C.indexOf("]",B);return C.slice(B,V)}const E={R:[],G:[],B:[],A:[],I:[],labels:[]};for(;o.endPos<r&&o.name.length>1;){if(o=a(),o.name.startsWith("Label Key")&&(C=o.name,E.I.push(M("Key=")),E.R.push(Math.round(255*M("Red=",!0))),E.G.push(Math.round(255*M("Green=",!0))),E.B.push(Math.round(255*M("Blue=",!0))),E.A.push(Math.round(255*M("Alpha",!0))),C=new TextDecoder().decode(e.slice(o.contentStartPos+1,o.contentEndPos)).trim(),E.labels.push(T("<![CDATA["))),o.name.trim()==="Data"){if(m)continue;C=new TextDecoder().decode(e.slice(o.contentStartPos+1,o.contentEndPos)).trim();let S;if(v){const U=g[0]*g[1]*g[2],B=C.split(/\s+/);if(U!==B.length)throw new Error("Unable to parse ASCII GIfTI");if(A===2&&(A=8),A===32&&(A=16),A===8){S=new Int32Array(U);for(let V=0;V<U;V++)S[V]=parseInt(B[V])}if(A===16){S=new Float32Array(U);for(let V=0;V<U;V++)S[V]=parseFloat(B[V])}}else if(typeof Buffer>"u"){let U=function(B){const V=atob(B),R=V.length,P=new Uint8Array(R);for(let L=0;L<R;L++)P[L]=V.charCodeAt(L);return P};if(y){const B=U(C.slice());S=await H.decompress(new Uint8Array(B))}else S=U(C.slice())}else if(y){const U=Buffer.from(C.slice(),"base64");S=await H.decompress(new Uint8Array(U))}else S=Buffer.from(C.slice(),"base64");if(u){if(A!==16&&F.warn("expect positions as FLOAT32"),l=new Float32Array(S.buffer),p){const U=l.slice(),B=U.length/3;let V=0;for(let R=0;R<B;R++)for(let P=0;P<3;P++)l[V]=U[P*B+R],V++}}else if(f){if(A!==8&&F.warn("expect indices as INT32"),c=new Uint32Array(S.buffer),p){const U=c.slice(),B=U.length/3;let V=0;for(let R=0;R<B;R++)for(let P=0;P<3;P++)c[V]=U[P*B+R],V++}}else{let U=function(V,R){const P=V.length,L=new Float32Array(P+R.length);return L.set(V),L.set(R,P),L};b=g[0]*g[1]*g[2],i!==0&&b%i!==0&&F.warn("Number of vertices in scalar overlay ("+b+") does not match mesh ("+i+")");let B;if(A===2){const V=new Uint8Array(S.buffer);B=Float32Array.from(V)}else if(A===8){const V=new Int32Array(S.buffer);B=Float32Array.from(V)}else if(A===16)B=new Float32Array(S.buffer);else if(A===32){const V=new Float64Array(S.buffer);B=Float32Array.from(V)}else throw new Error(`Invalid dataType: ${A}`);h=U(h,B)}continue}if(o.name.trim()==="DataSpace"&&(C=new TextDecoder().decode(e.slice(o.contentStartPos+1,o.contentEndPos)).trim(),C.includes("NIFTI_XFORM_SCANNER_ANAT")&&(w=!0)),o.name.trim()==="MD"&&(C=new TextDecoder().decode(e.slice(o.contentStartPos+1,o.contentEndPos)).trim(),C.includes("AnatomicalStructurePrimary")&&C.includes("CDATA[")&&(d=T("<Value><![CDATA[").toUpperCase()),C.includes("VolGeom")&&C.includes("CDATA["))){let S=-1;if(C.includes("VolGeomC_R")&&(S=0),C.includes("VolGeomC_A")&&(S=1),C.includes("VolGeomC_S")&&(S=2),S<0)continue;x[S]=parseFloat(T("<Value><![CDATA["))}o.name.startsWith("DataArray")&&(C=o.name,g=[1,1,1],y=C.includes('Encoding="GZipBase64Binary"'),v=C.includes('Encoding="ASCII"'),f=C.includes('Intent="NIFTI_INTENT_TRIANGLE"'),u=C.includes('Intent="NIFTI_INTENT_POINTSET"'),m=C.includes('Intent="NIFTI_INTENT_VECTOR"'),p=C.includes('ArrayIndexingOrder="ColumnMajorOrder"'),C.includes('DataType="NIFTI_TYPE_UINT8"')&&(A=2),C.includes('DataType="NIFTI_TYPE_INT32"')&&(A=8),C.includes('DataType="NIFTI_TYPE_FLOAT32"')&&(A=16),C.includes('DataType="NIFTI_TYPE_FLOAT64"')&&(A=32),g[0]=M("Dim0="),g[1]=M("Dim1="),g[2]=M("Dim2="))}let I;if(E.I.length>1&&(E.A.some(U=>U>0)||E.A.fill(255),I=re.makeLabelLut(E)),i>0)return{scalars:h,colormapLabel:I,anatomicalStructurePrimary:d};if(l.length>2&&!w&&(x[0]!==0||x[1]!==0||x[2]!==0)){b=Math.floor(l.length/3);let S=0;for(let U=0;U<b;U++)l[S]+=x[0],S++,l[S]+=x[1],S++,l[S]+=x[2],S++}return{positions:l,indices:c,scalars:h,colormapLabel:I,anatomicalStructurePrimary:d}}},Lc=(t=>(t.LEFT="left",t.RIGHT="right",t.CENTER="center",t))(Lc||{}),kc=(t=>(t.NONE="none",t.CIRCLE="circle",t.RING="ring",t))(kc||{}),Oc=(t=>(t[t.NONE=0]="NONE",t[t.TOPLEFT=9]="TOPLEFT",t[t.TOPCENTER=10]="TOPCENTER",t[t.TOPRIGHT=12]="TOPRIGHT",t[t.MIDDLELEFT=17]="MIDDLELEFT",t[t.MIDDLECENTER=18]="MIDDLECENTER",t[t.MIDDLERIGHT=20]="MIDDLERIGHT",t[t.BOTTOMLEFT=33]="BOTTOMLEFT",t[t.BOTTOMCENTER=34]="BOTTOMCENTER",t[t.BOTTOMRIGHT=36]="BOTTOMRIGHT",t))(Oc||{}),Um=class{constructor(t=[1,1,1,1],e=1,i="left",r=0,s=[0,0,0],n="none",a,o,l){D(this,"textColor"),D(this,"textScale"),D(this,"textAlignment"),D(this,"lineWidth"),D(this,"lineColor"),D(this,"lineTerminator"),D(this,"bulletScale"),D(this,"bulletColor"),D(this,"backgroundColor"),this.textColor=t,this.textScale=e,this.textAlignment=i,this.lineWidth=r,this.lineColor=s,this.lineTerminator=n,this.bulletScale=a,this.bulletColor=o,this.backgroundColor=l}},Er=class{constructor(t,e,i,r,s){D(this,"text"),D(this,"style"),D(this,"points"),D(this,"anchor"),D(this,"onClick"),this.text=t,this.style=e,this.points=i,this.anchor=r||0,this.onClick=s}},zc={colormap:"gray",opacity:0,nFrame4D:0,frame4D:0,outlineBorder:0,cal_min:0,cal_max:0,cal_minNeg:0,cal_maxNeg:0,colormapType:0,values:new Array,useNegativeCmap:!1,showLegend:!0},Rm=class{constructor(t="",e=null,i="",r=1,s=new Uint8Array([255,255,255,255]),n=!0,a=[],o=!0,l=0){D(this,"url"),D(this,"gl"),D(this,"name"),D(this,"opacity"),D(this,"rgba255"),D(this,"visible"),D(this,"layers"),D(this,"colorbarVisible"),D(this,"meshShaderIndex"),this.url=t,this.gl=e,this.name=i,this.opacity=r,this.rgba255=s,this.visible=n,this.layers=a,this.colorbarVisible=o,this.meshShaderIndex=l}},mt=class Le{constructor(e,i,r="",s=new Uint8Array([255,255,255,255]),n=1,a=!0,o,l=null,c=null,h=null,d=null,f=null,u=!0,m=""){D(this,"id"),D(this,"name"),D(this,"anatomicalStructurePrimary"),D(this,"colorbarVisible"),D(this,"furthestVertexFromOrigin"),D(this,"extentsMin"),D(this,"extentsMax"),D(this,"opacity"),D(this,"visible"),D(this,"meshShaderIndex",0),D(this,"offsetPt0",null),D(this,"colormapInvert",!1),D(this,"fiberGroupColormap",null),D(this,"indexBuffer"),D(this,"vertexBuffer"),D(this,"vao"),D(this,"vaoFiber"),D(this,"pts"),D(this,"tris"),D(this,"layers"),D(this,"type","mesh"),D(this,"data_type"),D(this,"rgba255"),D(this,"fiberLength"),D(this,"fiberLengths"),D(this,"fiberDensity"),D(this,"fiberDither",.1),D(this,"fiberColor","Global"),D(this,"fiberDecimationStride",1),D(this,"fiberSides",5),D(this,"fiberRadius",0),D(this,"fiberOcclusion",0),D(this,"f32PerVertex",5),D(this,"dpsThreshold",NaN),D(this,"fiberMask"),D(this,"colormap"),D(this,"dpg"),D(this,"dps"),D(this,"dpv"),D(this,"groups"),D(this,"hasConnectome",!1),D(this,"connectome"),D(this,"indexCount"),D(this,"vertexCount",1),D(this,"nodeScale",4),D(this,"edgeScale",1),D(this,"legendLineThickness",0),D(this,"showLegend",!0),D(this,"nodeColormap","warm"),D(this,"edgeColormap","warm"),D(this,"nodeColormapNegative"),D(this,"edgeColormapNegative"),D(this,"nodeMinColor"),D(this,"nodeMaxColor"),D(this,"edgeMin"),D(this,"edgeMax"),D(this,"nodes"),D(this,"edges"),D(this,"points"),this.anatomicalStructurePrimary=m,this.name=r,this.colorbarVisible=u,this.id=di();const p=$e.getExtents(e);if(this.furthestVertexFromOrigin=p.mxDx,this.extentsMin=p.extentsMin,this.extentsMax=p.extentsMax,this.opacity=n>1?1:n,this.visible=a,this.meshShaderIndex=0,this.indexBuffer=o.createBuffer(),this.vertexBuffer=o.createBuffer(),this.vao=o.createVertexArray(),o.bindVertexArray(this.vao),o.bindBuffer(o.ELEMENT_ARRAY_BUFFER,this.indexBuffer),o.bindBuffer(o.ARRAY_BUFFER,this.vertexBuffer),o.enableVertexAttribArray(0),o.enableVertexAttribArray(1),this.f32PerVertex!==7?(o.vertexAttribPointer(0,3,o.FLOAT,!1,20,0),o.vertexAttribPointer(1,4,o.BYTE,!0,20,12),o.enableVertexAttribArray(2),o.vertexAttribPointer(2,4,o.UNSIGNED_BYTE,!0,20,16)):(o.vertexAttribPointer(0,3,o.FLOAT,!1,28,0),o.vertexAttribPointer(1,3,o.FLOAT,!1,28,12),o.enableVertexAttribArray(2),o.vertexAttribPointer(2,4,o.UNSIGNED_BYTE,!0,28,24)),o.bindVertexArray(null),this.vaoFiber=o.createVertexArray(),this.offsetPt0=null,this.hasConnectome=!1,this.colormapInvert=!1,this.fiberGroupColormap=null,this.pts=e,this.layers=[],this.type="mesh",this.tris=i,s[3]<1){this.rgba255=s,this.fiberLength=2,this.fiberDither=.1,this.fiberColor="Global",this.fiberDecimationStride=1,this.fiberMask=[],this.colormap=l,this.dpg=c,this.dps=h,this.dpv=d,this.groups=f,c&&this.initValuesArray(c),h&&this.initValuesArray(h),d&&this.initValuesArray(d),f&&this.initValuesArray(f),this.offsetPt0=new Uint32Array(i),this.tris=new Uint32Array(0),this.updateFibers(o),o.bindVertexArray(this.vaoFiber),o.bindBuffer(o.ELEMENT_ARRAY_BUFFER,this.indexBuffer),o.bindBuffer(o.ARRAY_BUFFER,this.vertexBuffer),o.enableVertexAttribArray(0),o.vertexAttribPointer(0,3,o.FLOAT,!1,16,0),o.enableVertexAttribArray(1),o.vertexAttribPointer(1,4,o.UNSIGNED_BYTE,!0,16,12),o.bindVertexArray(null);return}if(l){this.connectome=l,this.hasConnectome=!0;const x=Object.keys(l);for(let A=0,y=x.length;A<y;A++)this[x[A]]=l[x[A]]}this.rgba255=s,this.updateMesh(o)}initValuesArray(e){for(let i=0;i<e.length;i++){const r=e[i].vals.reduce((n,a)=>Math.min(n,a)),s=e[i].vals.reduce((n,a)=>Math.max(n,a));e[i].global_min=r,e[i].global_max=s,e[i].cal_min=r,e[i].cal_max=s}return e}linesToCylinders(e,i,r){function s(T){return k(T[0],T[1],T[2])}const n=Math.pow(2,32)-1,a=r.length;let o=0,l=0;for(let T=0;T<a;T++){if(r[T]===n){l++;continue}o++}const c=this.fiberSides,h=c*o,d=this.f32PerVertex;if(d!==5)throw Error("fiberSides > 1 requires f32PerVertex == 5");const f=new Float32Array(h*d),u=new Uint8Array(f.buffer);let m=0,p=Xe(),g=Xe(),x=Xe();const A=se();let y=se(),v=0;const b=this.fiberRadius;for(let T=0;T<a;T++){const E=r[T]===n;if(E&&v<1)continue;let I=r[T]*4;if(v++,v<=1){p=ae(i[I+0],i[I+1],i[I+2],i[I+3]),g=ze(p),T+1<a&&r[T+1]!==n&&(I=r[T+1]*4,x=ae(i[I+0],i[I+1],i[I+2],i[I+3]),ne(A,s(p),s(x)),Ie(A,A),y=st.getFirstPerpVector(A));continue}E?x=ze(g):x=ae(i[I+0],i[I+1],i[I+2],i[I+3]),ne(A,s(p),s(x)),Ie(A,A);const S=se();Jt(S,y,A);const U=se();Jt(U,A,S),y=Ve(y);const B=se();Jt(B,A,U),Ie(B,B);const V=se();for(let R=0;R<c;R++){const P=Math.cos(R/c*2*Math.PI),L=Math.sin(R/c*2*Math.PI);V[0]=b*(P*U[0]+L*B[0]),V[1]=b*(P*U[1]+L*B[1]),V[2]=b*(P*U[2]+L*B[2]),it(V,s(g),V);const N=m*d;f[N+0]=V[0],f[N+1]=V[1],f[N+2]=V[2];const Y=se();ne(Y,V,s(g)),Ie(Y,Y);const _=(N+3)*4;u[_+0]=Y[0]*127,u[_+1]=Y[1]*127,u[_+2]=Y[2]*127,f[N+4]=g[3],m++}p=ze(g),g=ze(x),E&&(v=0)}const w=(o-l)*c*2*3,C=new Uint32Array(w);let M=0;m=0;for(let T=1;T<a;T++){if(r[T]===n){m+=c;continue}if(r[T-1]===n)continue;let E=m,I=m+c;const S=I,U=I+c;for(let B=0;B<c;B++)C[M++]=E,C[M++]=I++,I===U&&(I=U-c),C[M++]=I,C[M++]=E++,E===S&&(E=S-c),C[M++]=I,C[M++]=E;m+=c}e.bindBuffer(e.ELEMENT_ARRAY_BUFFER,this.indexBuffer),e.bufferData(e.ELEMENT_ARRAY_BUFFER,Uint32Array.from(C),e.STATIC_DRAW),e.bindBuffer(e.ARRAY_BUFFER,this.vertexBuffer),e.bufferData(e.ARRAY_BUFFER,u,e.STATIC_DRAW),this.indexCount=w}createFiberDensityMap(){if(this.fiberDensity)return;const e=this.pts,i=e.length/3;let r=0;for(let A=0;A<3;A++){const y=this.extentsMax[A]-this.extentsMin[A];r=Math.max(r,y)}if(this.fiberDensity=new Float32Array(i),r===0)return;const s=64,a=r/(s-1)/2,o=(s-1)/r;let l=new Float32Array(s*s*s);const c=[this.extentsMin[0]-a,this.extentsMin[1]-a,this.extentsMin[2]-a],h=[0,0,0],d=-1,f=s*s;let u=0;for(let A=0;A<i;A++){h[0]=Math.round((e[u++]-c[0])*o),h[1]=Math.round((e[u++]-c[1])*o),h[2]=Math.round((e[u++]-c[2])*o);const y=h[0]+h[1]*s+h[2]*f;y!==d&&l[y]++}function m(A,y){let v=A.slice(),b=-1;const w=y-1;for(let M=0;M<y;M++)for(let T=0;T<y;T++)for(let E=0;E<y;E++)b++,!(E<1||E>=w)&&(A[b]=v[b-1]+v[b]+v[b]+v[b+1]);b=-1,v=A.slice();for(let M=0;M<y;M++)for(let T=0;T<y;T++)for(let E=0;E<y;E++)b++,!(T<1||T>=w)&&(A[b]=v[b-y]+v[b]+v[b]+v[b+y]);const C=y*y;b=-1,v=A.slice();for(let M=0;M<y;M++)for(let T=0;T<y;T++)for(let E=0;E<y;E++)b++,!(M<1||M>=w)&&(A[b]=v[b-C]+v[b]+v[b]+v[C]);return A}l=m(l,s),l=m(l,s);let p=0,g=1/0;const x=s*s*s;for(let A=0;A<x;A++)l[A]<=0||(p=Math.max(p,l[A]),g=Math.min(g,l[A]));if(!(p<=1||p<=g)){u=0;for(let A=0;A<x;A++)l[A]=Math.max(0,l[A]-g);p-=g;for(let A=0;A<i;A++){h[0]=Math.round((e[u++]-c[0])*o),h[1]=Math.round((e[u++]-c[1])*o),h[2]=Math.round((e[u++]-c[2])*o);const y=h[0]+h[1]*s+h[2]*f;this.fiberDensity[A]=l[y]/p}}}updateFibers(e){if(!this.offsetPt0||!this.fiberLength)return;const i=this.pts,r=this.offsetPt0,s=r.length-1,n=i.length/3;if(!this.fiberLengths){this.fiberLengths=new Uint32Array(s);for(let w=0;w<s;w++){const C=r[w]*3,M=(r[w+1]-1)*3;let T=0;for(let E=C;E<M;E+=3){const I=k(i[E+0]-i[E+3],i[E+1]-i[E+4],i[E+2]-i[E+5]);T+=Vt(I)}this.fiberLengths[w]=T}}const a=new Float32Array(n*4),o=new Uint32Array(a.buffer);let l=0,c=0;for(let w=0;w<n;w++)a[c+0]=i[l+0],a[c+1]=i[l+1],a[c+2]=i[l+2],l+=3,c+=4;const h=this.fiberDither,d=h*.5;function f(w,C,M){const E=255*(h*Math.random()-d);return w=Math.max(Math.min(w+E,255),0),C=Math.max(Math.min(C+E,255),0),M=Math.max(Math.min(M+E,255),0),w+(C<<8)+(M<<16)}function u(w,C,M,T,E,I,S){const U=k(Math.abs(w-T),Math.abs(C-E),Math.abs(M-I));Ie(U,U);const B=S-d;for(let V=0;V<3;V++)U[V]=255*Math.max(Math.min(Math.abs(U[V])+B,1),0);return U[0]+(U[1]<<8)+(U[2]<<16)}const m=this.fiberColor.toLowerCase();let p=null,g=null;if(m.startsWith("dps")&&this.dps&&this.dps.length>0){const w=parseInt(m.substring(3));w<this.dps.length&&this.dps[w].vals.length===s&&(p=this.dps[w].vals)}if(m.startsWith("dpv")&&this.dpv&&this.dpv.length>0){const w=parseInt(m.substring(3));w<this.dpv.length&&this.dpv[w].vals.length===n&&(g=this.dpv[w])}const x=new Int16Array(s);if(this.groups&&this.fiberGroupColormap!==null||m.startsWith("dpg")&&this.dpg.length>0){const w=new Uint8ClampedArray(this.groups.length*4),C=new Array(this.groups.length).fill(!1);if(this.fiberGroupColormap){const M=this.fiberGroupColormap;M.A===void 0&&(M.A=Array.from(new Uint8ClampedArray(M.I.length).fill(255)));for(let T=0;T<M.I.length;T++){let E=M.I[T];E<0||E>=this.groups.length||M.A[T]<1||(C[E]=!0,E*=4,w[E]=M.R[T],w[E+1]=M.G[T],w[E+2]=M.B[T],w[E+3]=255)}}else if(m.startsWith("dpg")&&this.dpg.length>0){const M=parseInt(m.substring(3)),T=M<this.dpg.length?this.dpg[M]:this.dpg[0],E=re.colormap(this.colormap,this.colormapInvert),I=T.cal_min,S=T.cal_max,U=this.groups.length;for(let B=0;B<U;B++){const V=T.vals[B];if(V<I)continue;let R=Math.round(255*Math.min(Math.max((V-I)/(S-I),0),1));C[B]=!0;const P=B*4;R*=4,w[P]=E[R+0],w[P+1]=E[R+1],w[P+2]=E[R+2],w[P+3]=255}}x.fill(-1);for(let M=0;M<this.groups.length;M++){if(!C[M])continue;const T=this.groups[M];for(let E=0;E<T.vals.length;E++)x[T.vals[E]]=M}for(let M=0;M<s;M++){if(x[M]<0)continue;const T=x[M]%256*4,E=f(w[T],w[T+1],w[T+2]),I=r[M],S=r[M+1]-1,U=I*4+3,B=S*4+3;for(let V=U;V<=B;V+=4)o[V]=E}}else if(g){const w=re.colormap(this.colormap,this.colormapInvert),C=g.cal_min,M=g.cal_max;let T=3;for(let E=0;E<n;E++){let I=Math.min(Math.max((g.vals[E]-C)/(M-C),0),1);I=Math.round(Math.max(Math.min(255,I*255)))*4;const S=w[I]+(w[I+1]<<8)+(w[I+2]<<16);o[T]=S,T+=4}}else if(p){const w=re.colormap(this.colormap,this.colormapInvert);let C=p[0],M=p[0];for(let T=0;T<s;T++)C=Math.min(C,p[T]),M=Math.max(M,p[T]);M===C&&(C-=1);for(let T=0;T<s;T++){let E=(p[T]-C)/(M-C);E=Math.round(Math.max(Math.min(255,E*255)))*4;const I=w[E]+(w[E+1]<<8)+(w[E+2]<<16),S=r[T],U=r[T+1]-1,B=S*4+3,V=U*4+3;for(let R=B;R<=V;R+=4)o[R]=I}}else if(m.includes("fixed"))if(h===0){const w=this.rgba255[0]+(this.rgba255[1]<<8)+(this.rgba255[2]<<16);let C=3;for(let M=0;M<n;M++)o[C]=w,C+=4}else for(let w=0;w<s;w++){const C=f(this.rgba255[0],this.rgba255[1],this.rgba255[2]),M=r[w],T=r[w+1]-1,E=M*4+3,I=T*4+3;for(let S=E;S<=I;S+=4)o[S]=C}else if(m.includes("local"))for(let w=0;w<s;w++){const C=r[w],M=r[w+1]-1;let T=C*3;const E=M*3,I=h*Math.random();let S=u(i[T],i[T+1],i[T+2],i[T+4],i[T+5],i[T+6],I),U=C*4+3;for(;T<E;)o[U]=S,U+=4,T+=3,S=u(i[T-3],i[T-2],i[T-1],i[T+3],i[T+4],i[T+5],I);o[U]=o[U-4]}else for(let w=0;w<s;w++){const C=r[w],M=r[w+1]-1,T=C*3,E=M*3,I=u(i[T],i[T+1],i[T+2],i[E],i[E+1],i[E+2],h*Math.random()),S=C*4+3,U=M*4+3;for(let B=S;B<=U;B+=4)o[B]=I}if(this.fiberOcclusion>0){let w=function(C,M){const T=M*(C&255),E=M*(C>>8&255),I=M*(C>>16&255);return T+(E<<8)+(I<<16)};this.createFiberDensityMap();for(let C=0;C<s;C++){const M=r[C],T=r[C+1]-1,E=M*4+3,I=T*4+3;let S=M;const U=Math.min(this.fiberOcclusion,.99);for(let B=E;B<=I;B+=4){let V=this.fiberDensity[S++];if(V<=0)continue;V=V/((1/U-2)*(1-V)+1);const R=1-Math.min(V,.9);let P=o[B];P=w(P,R),o[B]=P}}}if(Number.isFinite(this.dpsThreshold)&&this.dps&&(p||this.dps[0].vals.length===s&&(p=this.dps[0].vals),p))for(let w=0;w<s;w++)p[w]<this.dpsThreshold&&(x[w]=-1);const A=this.fiberLength,y=Math.pow(2,32)-1,v=[];let b=-1;for(let w=0;w<s;w++)if(!(x[w]<0)&&!(this.fiberLengths[w]<A)&&(b++,b%this.fiberDecimationStride===0)){for(let C=r[w];C<r[w+1];C++)v.push(C);v.push(y)}this.fiberSides>2&&this.fiberRadius>0?this.linesToCylinders(e,a,v):(this.indexCount=v.length,e.bindBuffer(e.ARRAY_BUFFER,this.vertexBuffer),e.bufferData(e.ARRAY_BUFFER,Uint32Array.from(o),e.STATIC_DRAW),e.bindBuffer(e.ELEMENT_ARRAY_BUFFER,this.indexBuffer),e.bufferData(e.ELEMENT_ARRAY_BUFFER,Uint32Array.from(v),e.STATIC_DRAW))}indexNearestXYZmm(e,i,r){const s=this.pts,n=this.pts.length/3;let a=0,o=1/0,l=0;for(let c=0;c<n;c++){const h=Math.pow(s[a]-e,2)+Math.pow(s[a+1]-i,2)+Math.pow(s[a+2]-r,2);h<o&&(o=h,l=c),a+=3}return o=Math.sqrt(o),[l,o]}unloadMesh(e){if(e.bindBuffer(e.ARRAY_BUFFER,null),e.bindBuffer(e.ELEMENT_ARRAY_BUFFER,null),e.bindVertexArray(null),e.deleteBuffer(this.vertexBuffer),e.deleteBuffer(this.indexBuffer),e.deleteVertexArray(this.vao),e.deleteVertexArray(this.vaoFiber),this.offsetPt0=null,this.tris=null,this.pts=null,this.layers&&this.layers.length>0)for(let i=0;i<this.layers.length;i++)this.layers[i].values=null;if(this.dpg&&this.dpg.length>0)for(let i=0;i<this.dpg.length;i++)this.dpg[i].vals=null;if(this.dps&&this.dps.length>0)for(let i=0;i<this.dps.length;i++)this.dps[i].vals=null}scalars2RGBA(e,i,r,s=!1){const n=r.length;if(4*n<e.length)return F.error(`colormap2RGBA incorrectly specified ${n}*4 != ${e.length}`),e;const a=Math.round(i.opacity*255);let o=i.cal_min,l=i.cal_max,c=re.colormap(i.colormap,this.colormapInvert),h=1;if(s){if(!i.useNegativeCmap)return e;h=-1,c=re.colormap(i.colormapNegative,i.colormapInvert),o=i.cal_min,l=i.cal_max,isFinite(i.cal_minNeg)&&isFinite(i.cal_minNeg)&&(o=-i.cal_minNeg,l=-i.cal_maxNeg)}let d=o;i.isTransparentBelowCalMin||(d=Number.NEGATIVE_INFINITY);const f=i.colormapType===2;i.colormapType!==0&&(o=Math.min(o,0));const u=255/(l-o);for(let m=0;m<n;m++){let p=r[m]*h;if(isNaN(p))continue;let g=a;if(p<d)if(p>0&&f)g=Math.round(i.opacity*255*Math.pow(p/d,2));else continue;if(p=(p-o)*u,p<0&&i.isTransparentBelowCalMin)continue;p=Math.min(255,Math.max(0,Math.round(p)))*4;const x=m*4;e[x+0]=c[p+0],e[x+1]=c[p+1],e[x+2]=c[p+2],e[x+3]=g}return e}blendColormap(e,i,r,s,n,a,o=!1){const l=this.pts.length/3,c=Math.min(r.opacity,1);function h(y,v,b){return y*(1-b)+v*b}function d(y,v){return Math.min(y+v,255)}const f=o?-1:1,u=Math.min(Math.max(r.frame4D,0),r.nFrame4D-1),m=l*u;let p=s;r.isTransparentBelowCalMin||(p=Number.NEGATIVE_INFINITY),r.colormapType!==0&&(s=Math.min(s,0));const g=255/(n-s);let x=new Array(l).fill(!1);if(r.outlineBorder!==0){const y=new Uint8Array(l).fill(0);for(let v=0;v<l;v++)f*r.values[v+m]>=p&&(y[v]=1);x=$e.getClusterBoundaryU8(y,this.tris);for(let v=0;v<l;v++)f*r.values[v+m]<p&&(x[v]=!1)}const A=new Float32Array(256).fill(c);if(p>s&&r.colormapType===2){let y=Math.round((p-s)*g);y=Math.max(y,1);for(let v=1;v<y;v++)A[v]=c*Math.pow(v/y,2);A[0]=0,p=s+Number.EPSILON}for(let y=0;y<l;y++){const v=f*r.values[y+m];if(v<p)continue;let b=Math.round((v-s)*g);if(b<0&&r.isTransparentBelowCalMin)continue;b=Math.max(0,b),b=Math.min(255,b);let w=A[b];b*=4;let C=y*28+24;if(this.f32PerVertex!==7&&(C=y*20+16),r.isAdditiveBlend){const M=y*4;i[M+0]=d(i[M+0],a[b+0]),i[M+1]=d(i[M+1],a[b+1]),i[M+2]=d(i[M+2],a[b+2]),i[M+3]=d(i[M+3],255)}else{if(x[y]&&(w=r.outlineBorder,r.outlineBorder<0)){e[C+0]=0,e[C+1]=0,e[C+2]=0;continue}e[C+0]=h(e[C+0],a[b+0],w),e[C+1]=h(e[C+1],a[b+1],w),e[C+2]=h(e[C+2],a[b+2],w)}}}updateMesh(e){if(this.offsetPt0){this.updateFibers(e);return}if(this.hasConnectome)return;if(!this.pts||!this.tris||!this.rgba255){F.warn("underspecified mesh");return}function i(c,h,d){return c*(1-d)+h*d}const r=this.generatePosNormClr(this.pts,this.tris,this.rgba255),s=this.pts.length/3,n=new Uint8Array(r.buffer);let a=0;const o=new Uint8Array(s*4);let l=this.tris;if(this.layers&&this.layers.length>0)for(let c=0;c<this.layers.length;c++){const h=this.layers[c],d=h.opacity;if(d<=0||h.cal_min>h.cal_max)continue;if(h.outlineBorder===void 0&&(h.outlineBorder=0),h.isAdditiveBlend===void 0&&(h.isAdditiveBlend=!1),h.colormapLabel&&h.colormapLabel.R&&!h.colormapLabel.lut&&(h.colormapLabel=re.makeLabelLut(h.colormapLabel,255,h.global_max)),h.colormapLabel&&h.colormapLabel.lut){const u=h.colormapLabel;let m=0;h.colormapLabel.min&&(m=h.colormapLabel.min);let p=u.lut;const g=Math.floor(p.length/4);if(h.atlasValues&&g>0&&g===h.atlasValues.length&&h.colormap){const w=h.atlasValues;let C=!1,M=!0;for(let T=0;T<g;T++)isNaN(w[T])?C=!0:M=!1;if(M){F.debug("invisible mesh: all atlasValues are NaN.");return}if(C){F.debug("some vertices have NaN atlasValues (mesh will be decimated).");const T=new Array(s).fill(!1);for(let B=0;B<s;B++){const V=Math.round(h.values[B])-m;isNaN(w[V])&&(T[B]=!0)}const E=new Array(l.length).fill(!1);for(let B=0;B<l.length;B++)T[l[B]]&&(E[B]=!0);const I=this.tris;let S=0;for(let B=0;B<I.length;B+=3)!E[B]&&!E[B+1]&&!E[B+2]&&S++;S===0&&F.debug("invisible mesh: all triangles of a vertex with a NaN atlasValue."),l=new Uint32Array(S*3);let U=0;for(let B=0;B<I.length;B+=3)!E[B]&&!E[B+1]&&!E[B+2]&&(l[U++]=I[B],l[U++]=I[B+1],l[U++]=I[B+2])}p.fill(0),p=this.scalars2RGBA(p,h,w),h.useNegativeCmap&&(p=this.scalars2RGBA(p,h,w,!0))}else h.atlasValues&&F.warn(`Expected ${g} atlasValues but got ${h.atlasValues.length} for mesh layer`);if(h.showLegend&&g===h.colormapLabel.labels.length){h.labels=[];for(let w=0;w<g;w++){const C=Array.from(p.slice(w*4,w*4+4)).map(S=>S/255),M=h.colormapLabel.labels[w],T=[0,0,0];let E=0;for(let S=0;S<s;S++)if(h.values[S]===w){const U=S*3;T[0]+=this.pts[U],T[1]+=this.pts[U+1],T[2]+=this.pts[U+2],E++}if(E>0&&(T[0]/=E,T[1]/=E,T[2]/=E),C[3]===0||!M||M.startsWith("_"))continue;C[3]=1;const I=new Er(M,{textColor:C,bulletScale:1,bulletColor:C,lineWidth:0,lineColor:C,textScale:1,textAlignment:"left",lineTerminator:"none"},T);h.labels.push(I),F.debug("label for mesh layer:",I)}}else delete h.labels;const x=Math.min(Math.max(h.frame4D,0),h.nFrame4D-1),A=s*x,y=new Uint8Array(s*4);let v=0;for(let w=0;w<s;w++){const C=h.values[w+A]-m,M=4*Math.min(Math.max(C,0),g-1);y[v+0]=p[M+0],y[v+1]=p[M+1],y[v+2]=p[M+2],y[v+3]=Math.round(p[M+3]/255*h.opacity*255),v+=4}let b=new Array(s).fill(!1);h.outlineBorder!==0&&(b=$e.getClusterBoundary(y,this.tris)),v=0;for(let w=0;w<s;w++){let C=w*28+24;this.f32PerVertex!==7&&(C=w*20+16);let M=y[v+3]/255;if(b[w]&&(M=h.outlineBorder,h.outlineBorder<0)){n[C+0]=0,n[C+1]=0,n[C+2]=0,v+=4;continue}n[C+0]=i(n[C+0],y[v+0],M),n[C+1]=i(n[C+1],y[v+1],M),n[C+2]=i(n[C+2],y[v+2],M),v+=4}continue}if(h.values instanceof Uint8Array){const u=new Uint8Array(h.values.buffer);let m=new Array(s).fill(!0);h.outlineBorder!==0&&(m=$e.getClusterBoundary(u,this.tris));let p=0;for(let g=0;g<h.values.length;g++){let x=g*28+24;this.f32PerVertex!==7&&(x=g*20+16);let A=d;if(m[g]&&(A=h.outlineBorder,h.outlineBorder<0)){n[x+0]=0,n[x+1]=0,n[x+2]=0,p+=4;continue}n[x+0]=i(n[x+0],u[p+0],A),n[x+1]=i(n[x+1],u[p+1],A),n[x+2]=i(n[x+2],u[p+2],A),p+=4}continue}h.useNegativeCmap&&(h.cal_min=Math.max(Number.EPSILON,h.cal_min),h.cal_max=Math.max(h.cal_min+1e-6,h.cal_max)),h.isTransparentBelowCalMin===void 0&&(h.isTransparentBelowCalMin=!0);const f=re.colormap(h.colormap,h.colormapInvert);if(h.isAdditiveBlend&&a++,this.blendColormap(n,o,h,h.cal_min,h.cal_max,f),h.useNegativeCmap){const u=re.colormap(h.colormapNegative,h.colormapInvert);let m=h.cal_min,p=h.cal_max;isFinite(h.cal_minNeg)&&isFinite(h.cal_minNeg)&&(m=-h.cal_minNeg,p=-h.cal_maxNeg),this.blendColormap(n,o,h,m,p,u,!0)}}if(a>0)for(let c=0;c<s;c++){let h=function(m,p){return Math.min(m*p*.00392156862745098,255)},d=c*28+24;this.f32PerVertex!==7&&(d=c*20+16);const f=c*4,u=Math.min(a,o[f+3]/255);u<=0||(n[d+0]=h(n[d+0],o[f+0]),n[d+1]=h(n[d+1],o[f+1]),n[d+2]=h(n[d+2],o[f+2]),n[d+0]=i(n[d+0],o[f+0],u),n[d+1]=i(n[d+1],o[f+1],u),n[d+2]=i(n[d+2],o[f+2],u))}e.bindBuffer(e.ELEMENT_ARRAY_BUFFER,this.indexBuffer),e.bufferData(e.ELEMENT_ARRAY_BUFFER,Uint32Array.from(l),e.STATIC_DRAW),e.bindBuffer(e.ARRAY_BUFFER,this.vertexBuffer),e.bufferData(e.ARRAY_BUFFER,n,e.STATIC_DRAW),this.indexCount=l.length,this.vertexCount=this.pts.length}reverseFaces(e){if(this.offsetPt0||this.hasConnectome)return;const i=this.tris||[];for(let r=0;r<i.length;r+=3){const s=i[r];i[r]=i[r+1],i[r+1]=s}this.updateMesh(e)}hierarchicalOrder(){const r=this.tris.length/3,s=Math.log(r/20)/Math.log(4);if(r!==Math.pow(4,s)*20)return NaN;if(this.pts.length/3!==Math.pow(4,s)*10+2)return NaN;for(let a=0;a<15;a+=3)if(this.tris[a]!==0)return NaN;for(let a=15;a<24;a+=3)if(this.tris[a]!==3)return NaN;for(let a=24;a<30;a+=3)if(this.tris[a]!==4)return NaN;return s}decimateFaces(e,i){let r=this.tris;const s=12,n=20;for(let a=e-1;a>=i;a--){const o=Math.pow(4,a+1)*(s-2)+2,l=Math.pow(4,a)*(s-2)+2,c=r.length/3,h=Math.pow(4,a)*n;F.info(`order ${a+1} -> ${a} vertices ${o} -> ${l} faces ${c} -> ${h}`);const d=Array.from({length:o},(u,m)=>m+1);for(let u=0;u<c;u++){const m=r[3*u],p=r[3*u+1],g=r[3*u+2];d[m-1]=Math.min(d[m-1],p,g)}const f=new Uint32Array(h*3);for(let u=0;u<h;u++)f[3*u]=d[r[3*u]-1],f[3*u+1]=d[r[3*u+1]-1],f[3*u+2]=d[r[3*u+2]-1];r=f}this.tris=new Uint32Array(r)}decimateHierarchicalMesh(e,i=4){const r=this.hierarchicalOrder();if(isNaN(r))return F.warn("Unable to decimate mesh: it does not have a hierarchical structure"),!1;if(i>=r)return F.warn(`Unable to decimate mesh: input order (${r}) must be larger than downsampled order (${i})`),!1;const s=this.pts.length/3,a=Math.pow(4,i)*(12-2)+2;if(this.pts=new Float32Array(this.pts.slice(0,a*3)),this.decimateFaces(r,i),this.layers&&this.layers.length>0)for(let o=0;o<this.layers.length;o++){const l=this.layers[o];l.values instanceof Float32Array||l.values.length!==s?l.values=new Float32Array(l.values.slice(0,a)):F.warn("decimation logic needs to be updated")}return this.updateMesh(e),!0}async setLayerProperty(e,i,r,s){const n=this.layers[e];if(!n||!(i in n)){F.warn("mesh does not have property ",i," for layer ",n);return}if(i==="colormapLabel")if(typeof r=="object")n[i]=re.makeLabelLut(r,255,n.global_max);else if(typeof r=="string"){const a=await re.makeLabelLutFromUrl(r);n[i]=a,this.updateMesh(s);return}else F.error("colormapLabel requires a string or object");else n[i]=r;this.updateMesh(s)}setProperty(e,i,r){if(!(e in this)){console.warn("Mesh does not have property:",e,this);return}this[e]=i,this.updateMesh(r)}generatePosNormClr(e,i,r){(e.length<3||r.length<4)&&(F.error("Catastrophic failure generatePosNormClr()"),F.debug("this",this),F.debug("pts",e),F.debug("rgba",r));const s=$e.generateNormals(e,i),n=e.length/3,a=n===r.length/4,o=this.f32PerVertex,l=new Float32Array(n*o),c=new Uint8Array(l.buffer);let h=0,d=0,f=0,u=(o-1)*4;for(let m=0;m<n;m++)l[f+0]=e[h+0],l[f+1]=e[h+1],l[f+2]=e[h+2],o!==7?(c[u-4]=s[h+0]*127,c[u-3]=s[h+1]*127,c[u-2]=s[h+2]*127):(l[f+3]=s[h+0],l[f+4]=s[h+1],l[f+5]=s[h+2]),c[u]=r[d+0],c[u+1]=r[d+1],c[u+2]=r[d+2],c[u+3]=r[d+3],a&&(d+=4),h+=3,f+=o,u+=o*4;return l}static async readMesh(e,i,r,s=1,n=new Uint8Array([255,255,255,255]),a=!0){let o=new Uint32Array([]),l=new Float32Array([]),c="",h;const d=/(?:\.([^.]+))?$/;let f=d.exec(i)[1];if(f=f.toUpperCase(),f==="GZ"&&(f=d.exec(i.slice(0,-3))[1],f=f.toUpperCase()),f==="JCON"&&F.error("you should never see this message: load using nvconnectome not nvmesh"),f==="JSON"&&F.error("you should never see this message: load using nvconnectome not nvmesh"),n[3]=Math.max(1,n[3]),f==="TCK"||f==="TRK"||f==="TT"||f==="TRX"||f==="TRACT"){if(f==="TCK"?h=ce.readTCK(e):f==="TRACT"?h=ce.readTRACT(e):f==="TT"?h=await ce.readTT(e):f==="TRX"?h=await ce.readTRX(e):h=await ce.readTRK(e),typeof h>"u"){const g=new Float32Array([0,0,0,0,0,0]),x=new Uint32Array([0]);h={pts:g,offsetPt0:x},F.error("Creating empty tracts")}return n[3]=0,new Le(h.pts,h.offsetPt0,i,n,s,a,r,"inferno",h.dpg||null,h.dps||null,h.dpv||null,h.groups)}if(f==="GII")h=await ce.readGII(e);else if(f==="MZ3")h=await ce.readMZ3(e),"positions"in h||F.warn("MZ3 does not have positions (statistical overlay?)");else if(f==="ASC")h=ce.readASC(e);else if(f==="DFS")h=ce.readDFS(e);else if(f==="BYU"||f==="G")h=ce.readGEO(e);else if(f==="GEO")h=ce.readGEO(e,!0);else if(f==="ICO"||f==="TRI")h=ce.readICO(e);else if(f==="OFF")h=ce.readOFF(e);else if(f==="NV")h=ce.readNV(e);else if(f==="OBJ")h=await ce.readOBJ(e);else if(f==="PLY")h=ce.readPLY(e);else if(f==="WRL")h=ce.readWRL(e);else if(f==="X3D")h=ce.readX3D(e);else if(f==="FIB"||f==="VTK"){if(h=ce.readVTK(e),"offsetPt0"in h)return n[3]=0,new Le(h.pts,h.offsetPt0,i,n,s,a,r,"inferno")}else f==="SRF"?h=await ce.readSRF(e):f==="STL"?h=ce.readSTL(e):h=ce.readFreeSurfer(e);if(h.anatomicalStructurePrimary&&(c=h.anatomicalStructurePrimary),h instanceof Float32Array)throw new Error("fatal: unknown mesh type loaded");if(!("positions"in h))throw new Error("positions not loaded");if(!h.indices)throw new Error("indices not loaded");if(l=h.positions,o=h.indices,"rgba255"in h&&h.rgba255.length>0&&(n=h.rgba255),"colors"in h&&h.colors&&h.colors.length===l.length){const g=l.length/3;n=new Uint8Array(g*4);let x=0,A=0;for(let y=0;y<g;y++)n[A++]=h.colors[x]*255,n[A++]=h.colors[x+1]*255,n[A++]=h.colors[x+2]*255,n[A++]=255,x+=3}const u=l.length/3;if(o.length/3<1||u<3)throw new Error("Mesh should have at least one triangle and three vertices");n[3]=Math.max(1,n[3]);const p=new Le(l,o,i,n,s,a,r,null,null,null,null,null,!0,c);if("scalars"in h&&h.scalars.length>0){const g=await ce.readLayer(i,e,p,s,"gray");typeof g>"u"?F.warn("readLayer() failed to convert scalars"):(p.layers.push(g),p.updateMesh(r))}return p}static async loadLayer(e,i){let r=new Uint8Array().buffer;function s(m){const p=window.atob(m),g=p.length,x=new Uint8Array(g);for(let A=0;A<g;A++)x[A]=p.charCodeAt(A);return x.buffer}if(e.base64!==void 0)r=s(e.base64);else{if(!e.url)throw new Error("layer: missing url");const m=await fetch(e.url,{headers:e.headers});if(!m.ok)throw Error(m.statusText);r=await m.arrayBuffer()}let n,a=[];if(e.name&&e.name!=="")n=e.name;else{if(!e.url)throw new Error("layer: missing url");try{a=new URL(e.url).pathname.split("/")}catch{a=e.url.split("/")}finally{n=a.slice(-1)[0]}}n.indexOf("?")>-1&&(n=n.slice(0,n.indexOf("?")));let o=.5;"opacity"in e&&(o=e.opacity);let l="warm";"colormap"in e&&(l=e.colormap);let c="winter";"colormapNegative"in e&&(c=e.colormapNegative);let h=!1;"useNegativeCmap"in e&&(h=e.useNegativeCmap);let d=null;"cal_min"in e&&(d=e.cal_min);let f=null;"cal_max"in e&&(f=e.cal_max);const u=await ce.readLayer(n,r,i,o,l,c,h,d,f);u&&i.layers.push(u)}static async loadFromUrl({url:e="",headers:i={},gl:r,name:s="",opacity:n=1,rgba255:a=[255,255,255,255],visible:o=!0,layers:l=[],buffer:c=new ArrayBuffer(0),meshShaderIndex:h=0}={}){let d=e.split("/");if(s===""){try{d=new URL(e).pathname.split("/")}catch{d=e.split("/")}s=d.slice(-1)[0],s.indexOf("?")>-1&&(s=s.slice(0,s.indexOf("?")))}if(e==="")throw Error("url must not be empty");if(!r)throw Error("gl context is null");let f;if(c.byteLength>0)f=c;else{const m=await fetch(e,{headers:i});if(!m.ok)throw Error(m.statusText);f=await m.arrayBuffer()}const u=await this.readMesh(f,s,r,n,new Uint8Array(a),o);if(h!==void 0&&(u.meshShaderIndex=h),!l||l.length<1)return u;for(let m=0;m<l.length;m++)await Le.loadLayer(l[m],u);return u.updateMesh(r),u}static async readFileAsync(e){return new Promise((i,r)=>{const s=new FileReader;s.onload=()=>{i(s.result)},s.onerror=r,s.readAsArrayBuffer(e)})}static async loadFromFile({file:e,gl:i,name:r="",opacity:s=1,rgba255:n=[255,255,255,255],visible:a=!0,layers:o=[]}={}){if(!e)throw new Error("file must be set");if(!i)throw new Error("rendering context must be set");const l=await Le.readFileAsync(e),c=await Le.readMesh(l,r,i,s,new Uint8Array(n),a);if(!o||o.length<1)return c;for(let h=0;h<o.length;h++)await Le.loadLayer(o[h],c);return c.updateMesh(i),c}async loadFromBase64({base64:e,gl:i,name:r="",opacity:s=1,rgba255:n=[255,255,255,255],visible:a=!0,layers:o=[]}={}){if(!e)throw new Error("base64 must bet set");if(!i)throw new Error("rendering context must be set");function l(d){const f=window.atob(d),u=f.length,m=new Uint8Array(u);for(let p=0;p<u;p++)m[p]=f.charCodeAt(p);return m.buffer}const c=l(e),h=await Le.readMesh(c,r,i,s,new Uint8Array(n),a);if(!o||o.length<1)return h;for(let d=0;d<o.length;d++)await Le.loadLayer(o[d],h);return 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",fs="data:image/png;base64,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Uint8Array(x);let A=0;for(const y of g)a.set(y,A),A+=y.length}const o=348;r.vox_offset=Math.max(352,o+n.length+a.length),i&&(r.datatypeCode=2,r.numBitsPerVoxel=8,r.scl_slope=1,r.scl_inter=0);const l=ui(r,i);let c;if(i){const g=e,x=t.permRAS;if(x&&(x[0]!==1||x[1]!==2||x[2]!==3)){F.debug("Reorienting drawing bytes back to native space for saving...");const A=t.hdr.dims,y=A[1]*A[2]*A[3],v=t.dimsRAS?t.dimsRAS[1]*t.dimsRAS[2]*t.dimsRAS[3]:y;if(g.length!==v)console.warn(`Drawing length (${g.length}) does not match expected RAS voxel count (${v}). 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Cannot reorient drawing reliably."),c=g;else{const b=t.img2RASstep,w=t.img2RASstart,C=t.dimsRAS,M=new Uint8Array(y);M.fill(0);const T=g;let E=0;for(let I=0;I<C[3];I++){const S=w[2]+I*b[2];for(let U=0;U<C[2];U++){const B=w[1]+U*b[1];for(let V=0;V<C[1];V++){const P=w[0]+V*b[0]+B+S;P>=0&&P<y?M[P]=T[E]:E<T.length&&console.warn(`Calculated native index ${P} is out of bounds [0..${y-1}] during drawing reorientation.`),E++}}}c=M}}else c=g}else{if(!t.img)throw new Error("NVImage image data is null when trying to save non-drawing.");c=new Uint8Array(t.img.buffer,t.img.byteOffset,t.img.byteLength)}const h=l.length+n.length+a.length,d=Math.max(0,r.vox_offset-h),f=new Uint8Array(d),u=r.vox_offset+c.length,m=new Uint8Array(u);let p=0;return m.set(l,p),p+=l.length,m.set(n,p),p+=n.length,m.set(a,p),p+=a.length,m.set(f,p),p+=f.length,m.set(c,r.vox_offset),m}async function Cn(t,e,i=null){const r=bn(t,i);if(e.toLowerCase().endsWith(".gz"))try{const n=await H.compress(r,"gzip");return new Uint8Array(n)}catch(n){return F.error("Compression failed:",n),F.warn("Returning uncompressed data due to compression error."),r}else return r}async function ih(t,e="",i=null){const r=await Cn(t,e,i);if(!e)return F.debug("saveToDisk: empty file name, returning data as Uint8Array rather than triggering download"),r;try{const s=new Blob([r.buffer],{type:"application/octet-stream"}),n=URL.createObjectURL(s),a=document.createElement("a");a.setAttribute("href",n),a.setAttribute("download",e),a.style.visibility="hidden",document.body.appendChild(a),a.click(),document.body.removeChild(a),setTimeout(()=>URL.revokeObjectURL(n),100)}catch(s){F.error("Failed to trigger download:",s)}return r}function Mn(t,e,i,r,s=0,n=!1){if(!t.hdr)throw new Error("getValue: NVImage header is not defined.");if(!n&&!t.img)throw new Error("getValue: NVImage image data is not defined.");if(n&&!t.imaginary)return F.warn("getValue: Attempted to read imaginary data, but none exists."),[0];const a=t.hdr.dims[1],o=t.hdr.dims[2],l=t.hdr.dims[3],c=t.permRAS.slice();if(c[0]!==1||c[1]!==2||c[2]!==3){const A=ae(e,i,r,1);ve(A,A,t.toRASvox),e=A[0],i=A[1],r=A[2]}e=Math.max(0,Math.min(Math.round(e),a-1)),i=Math.max(0,Math.min(Math.round(i),o-1)),r=Math.max(0,Math.min(Math.round(r),l-1)),s=Math.max(0,s);let h=e+i*a+r*a*o;if(t.hdr.datatypeCode===2304)return t.img?(h*=4,h+3>=t.img.length?(F.warn(`getValue: Calculated index ${h} out of bounds for RGBA data.`),[0]):[t.img[h],t.img[h+1],t.img[h+2],t.img[h+3]]):[0];if(t.hdr.datatypeCode===128)return t.img?(h*=3,h+2>=t.img.length?(F.warn(`getValue: Calculated index ${h} out of bounds for RGB data.`),[0]):[t.img[h],t.img[h+1],t.img[h+2]]):[0];const d=a*o*l,f=s*d,u=h+f,m=n?t.imaginary:t.img;if(u<0||u>=m.length)return[0];const p=m[u],g=isNaN(t.hdr.scl_slope)||t.hdr.scl_slope===0?1:t.hdr.scl_slope,x=isNaN(t.hdr.scl_inter)?0:t.hdr.scl_inter;return[g*p+x]}function rh(t,e,i,r,s=0,n=!1){const a=Mn(t,e,i,r,s,n);return a.length<3?a[0]:a[0]*.2126+a[1]*.7152+a[2]*.0722}function sh(t,e=[-1,0,0],i=[0,0,0],r="same"){const s=[new Uint8Array,[0,0,0]];if(!t.hdr||!t.img||!t.dimsRAS||!t.img2RASstep||!t.img2RASstart)return F.error("getVolumeData: Missing required NVImage properties (hdr, img, dimsRAS, img2RASstep/start)."),s;if(e=e.slice(0,3),i=i.slice(0,3),Math.min(...e)<0||Math.min(...i)<0)return F.warn("getVolumeData: Invalid start or end coordinates provided."),s;const n=t.dimsRAS.slice(1,4);for(let g=0;g<3;g++)if(e[g]=Math.max(0,Math.min(Math.round(e[g]),n[g]-1)),i[g]=Math.max(0,Math.min(Math.round(i[g]),n[g]-1)),i[g]<e[g]){const x=i[g];i[g]=e[g],e[g]=x}const a=[i[0]-e[0]+1,i[1]-e[1]+1,i[2]-e[2]+1],o=a[0]*a[1]*a[2];if(o<=0)return F.warn("getVolumeData: Calculated slab size is zero or negative."),s;let l=t.img.constructor;r==="uint8"?l=Uint8Array:r==="int16"?l=Int16Array:r==="uint16"?l=Uint16Array:r==="float32"||r==="scaled"||r==="normalized"||r==="windowed"?l=Float32Array:r==="float64"?l=Float64Array:r!=="same"&&F.warn(`getVolumeData: Unsupported dataType '${r}'. Using 'same'.`);let c;try{c=new l(o)}catch(g){return F.error(`getVolumeData: Failed to create output array for dataType '${r}'.`,g),s}const h=t.img2RASstep,d=t.img2RASstart,f=t.img;let u=0;for(let g=e[2];g<=i[2];g++){const x=d[2]+g*h[2];for(let A=e[1];A<=i[1];A++){const y=d[1]+A*h[1];for(let v=e[0];v<=i[0];v++){const w=d[0]+v*h[0]+y+x;let C=0;w>=0&&w<f.length&&(C=f[w]),c[u++]=C}}}const m=isNaN(t.hdr.scl_slope)||t.hdr.scl_slope===0?1:t.hdr.scl_slope,p=isNaN(t.hdr.scl_inter)?0:t.hdr.scl_inter;if(r==="scaled"||r==="normalized"||r==="windowed"){c instanceof Float32Array||(F.warn(`getVolumeData: Converting output to Float32 for scaling type '${r}'.`),c=Float32Array.from(c));for(let g=0;g<c.length;g++)c[g]=c[g]*m+p}if(r==="normalized"||r==="windowed"){let g=t.cal_min,x=t.cal_max;r==="normalized"&&(g=t.global_min,x=t.global_max);const A=x-g,y=A===0?0:1/A;for(let v=0;v<c.length;v++)c[v]=(c[v]-g)*y,c[v]=Math.max(0,Math.min(c[v],1))}return[c,a]}function nh(t,e=[-1,0,0],i=[0,0,0],r=new Uint8Array){if(!t.hdr||!t.img||!t.dimsRAS||!t.img2RASstep||!t.img2RASstart){F.error("setVolumeData: Missing required NVImage properties (hdr, img, dimsRAS, img2RASstep/start).");return}if(r.length<1){F.warn("setVolumeData: Input slabData is empty.");return}if(e=e.slice(0,3),i=i.slice(0,3),Math.min(...e)<0||Math.min(...i)<0){F.warn("setVolumeData: Invalid start or end coordinates provided.");return}const s=t.dimsRAS.slice(1,4);for(let d=0;d<3;d++)if(e[d]=Math.max(0,Math.min(Math.round(e[d]),s[d]-1)),i[d]=Math.max(0,Math.min(Math.round(i[d]),s[d]-1)),i[d]<e[d]){const f=i[d];i[d]=e[d],e[d]=f}const n=[i[0]-e[0]+1,i[1]-e[1]+1,i[2]-e[2]+1],a=n[0]*n[1]*n[2];if(a<=0){F.warn("setVolumeData: Calculated slab size is zero or negative.");return}if(r.length<a){F.error(`setVolumeData: Input slabData length (${r.length}) is less than the calculated slab size (${a}).`);return}const o=t.img2RASstep,l=t.img2RASstart,c=t.img;let h=0;for(let d=e[2];d<=i[2];d++){const f=l[2]+d*o[2];for(let u=e[1];u<=i[1];u++){const m=l[1]+u*o[1];for(let p=e[0];p<=i[0];p++){const x=l[0]+p*o[0]+m+f;x>=0&&x<c.length&&(c[x]=r[h]),h++}}}}var tr={};be(tr,{readHEAD:()=>lh});function Wt(t,e){const i=de(e);Te(i,i);const r=ae(t[0],t[1],t[2],1);return ve(r,r,i),k(r[0],r[1],r[2])}function ah(t){if(!t.hdr)throw new Error("hdr not defined");const e=t.hdr.affine,i=Ee(e[0][0],e[0][1],e[0][2],e[0][3],e[1][0],e[1][1],e[1][2],e[1][3],e[2][0],e[2][1],e[2][2],e[2][3],e[3][0],e[3][1],e[3][2],e[3][3]),r=Wt([0,0,0],i),s=Wt([1,0,0],i);ne(s,s,r);const n=Wt([0,1,0],i);ne(n,n,r);const a=Wt([0,0,1],i);ne(a,a,r),t.hdr.pixDims[1]=Qe(s),t.hdr.pixDims[2]=Qe(n),t.hdr.pixDims[3]=Qe(a)}function oh(t,e,i,r){const s=t.hdr;if(s===null)throw new Error("HDR is not set");s.sform_code=2;const n="xxyyzzg";let a=-1,o=-1,l=-1;const c=["x","y","z"];c[0]=n[r[0]],c[1]=n[r[1]],c[2]=n[r[2]];const h=e.slice(0,3),d=i.slice(0,3);for(let f=0;f<3;f++)c[f]==="x"?a=f:c[f]==="y"?o=f:l=f;a<0||o<0||l<0||a===o||a===l||o===l||(s.pixDims[1]=Math.abs(h[0]),s.pixDims[2]=Math.abs(h[1]),s.pixDims[3]=Math.abs(h[2]),s.affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],s.affine[0][a]=-h[a],s.affine[1][o]=-h[o],s.affine[2][l]=h[l],s.affine[0][3]=-d[a],s.affine[1][3]=-d[o],s.affine[2][3]=d[l])}async function lh(t,e,i){t.hdr=new G;const r=t.hdr;r.dims[0]=3,r.pixDims=[1,1,1,1,1,0,0,0];let s=[0,0,0],n=[0,0,0],a=[1,1,1];const l=new TextDecoder().decode(e).split(/\r?\n/),c=(e.byteLength+8)%16,h=e.byteLength+(16-c);F.debug(e.byteLength,"len",h);const d=new ArrayBuffer(h);new Uint8Array(d).set(new Uint8Array(e));const f=new sn(h+8,42,d,!0);r.addExtension(f),r.extensionCode=42,r.extensionFlag[0]=1,r.extensionSize=h+8;const u=l.length;let m=0,p=!1;for(;m<u;){let x=l[m];if(m++,!x.startsWith("type"))continue;const A=x.includes("integer-attribute"),y=x.includes("float-attribute");if(x=l[m],m++,!x.startsWith("name"))continue;let v=x.split("= ");const b=v[1];x=l[m],m++,v=x.split("= ");let w=parseInt(v[1]);if(!(w<1)){if(x=l[m],m++,v=x.trim().split(/\s+/),y||A){for(;v.length<w;){x=l[m],m++;const C=x.trim().split(/\s+/);v.push(...C)}for(let C=0;C<w;C++)v[C]=parseFloat(v[C])}switch(b){case"BYTEORDER_STRING":v[0].includes("LSB_FIRST")?r.littleEndian=!0:v[0].includes("MSB_FIRST")&&(r.littleEndian=!1);break;case"BRICK_TYPES":{r.dims[4]=w;const C=parseInt(v[0]);C===0?(r.numBitsPerVoxel=8,r.datatypeCode=2):C===1?(r.numBitsPerVoxel=16,r.datatypeCode=4):C===3?(r.numBitsPerVoxel=32,r.datatypeCode=16):F.warn("Unknown BRICK_TYPES ",C)}break;case"IJK_TO_DICOM_REAL":if(w<12)break;p=!0,r.sform_code=2,r.affine=[[-v[0],-v[1],-v[2],-v[3]],[-v[4],-v[5],-v[6],-v[7]],[v[8],v[9],v[10],v[11]],[0,0,0,1]];break;case"DATASET_DIMENSIONS":w=Math.max(w,3);for(let C=0;C<w;C++)r.dims[C+1]=v[C];break;case"ORIENT_SPECIFIC":s=v;break;case"ORIGIN":n=v;break;case"DELTA":a=v;break;case"TAXIS_FLOATS":r.pixDims[4]=v[0];break;default:F.warn("Unknown:",b)}}}p?ah(t):oh(t,a,n,s);const g=r.numBitsPerVoxel/8*r.dims[1]*r.dims[2]*r.dims[3]*r.dims[4];if(!i)throw new Error("pairedImgData not set");return i.byteLength<g?await H.decompressToBuffer(new Uint8Array(i)):i.slice(0)}var Ct={};be(Ct,{readV16:()=>ch,readVMR:()=>hh});function ch(t,e){t.hdr=new G;const i=t.hdr;i.dims=[3,1,1,1,0,0,0,0],i.pixDims=[1,1,1,1,1,0,0,0];const r=new DataView(e);return i.dims[1]=r.getUint16(0,!0),i.dims[2]=r.getUint16(2,!0),i.dims[3]=r.getUint16(4,!0),2*i.dims[1]*i.dims[2]*i.dims[3]+6!==e.byteLength&&F.warn("This does not look like a valid BrainVoyager V16 file"),i.numBitsPerVoxel=16,i.datatypeCode=512,F.warn("Warning: V16 files have no spatial transforms"),i.affine=[[0,0,-i.pixDims[1],(i.dims[1]-2)*.5*i.pixDims[1]],[-i.pixDims[2],0,0,(i.dims[2]-2)*.5*i.pixDims[2]],[0,-i.pixDims[3],0,(i.dims[3]-2)*.5*i.pixDims[3]],[0,0,0,1]],i.littleEndian=!0,e.slice(6)}function hh(t,e){t.hdr=new G;const i=t.hdr;i.dims=[3,1,1,1,0,0,0,0],i.pixDims=[1,1,1,1,1,0,0,0];const r=new DataView(e),s=r.getUint16(0,!0);s!==4&&F.warn("Not a valid version 4 VMR image"),i.dims[1]=r.getUint16(2,!0),i.dims[2]=r.getUint16(4,!0),i.dims[3]=r.getUint16(6,!0);const n=i.dims[1]*i.dims[2]*i.dims[3];if(s>=4){let a=8+n;const o=r.getUint32(a+88,!0);if(a=a+92,o>0){const l=e.byteLength;for(let c=0;c<o;c++){for(;a<l&&r.getUint8(a)!==0;)a++;for(a++,a+=4;a<l&&r.getUint8(a)!==0;)a++;a++;const h=r.getUint32(a,!0);a+=4;for(let d=0;d<h;d++)a+=4}}i.pixDims[1]=r.getFloat32(a+2,!0),i.pixDims[2]=r.getFloat32(a+6,!0),i.pixDims[3]=r.getFloat32(a+10,!0)}return F.warn("Warning: VMR spatial transform not implemented"),i.affine=[[0,0,-i.pixDims[1],(i.dims[1]-2)*.5*i.pixDims[1]],[-i.pixDims[2],0,0,(i.dims[2]-2)*.5*i.pixDims[2]],[0,-i.pixDims[3],0,(i.dims[3]-2)*.5*i.pixDims[3]],[0,0,0,1]],F.debug(i),i.numBitsPerVoxel=8,i.datatypeCode=2,e.slice(8,8+n)}var Mt={};be(Mt,{readFIB:()=>dh,readSRC:()=>fh});async function dh(t,e){t.hdr=new G;const i=t.hdr;i.littleEndian=!1,i.dims=[3,1,1,1,0,0,0,0],i.pixDims=[1,1,1,1,1,0,0,0];const r=await H.readMatV4(e,!0);if(!("dimension"in r)||!("dti_fa"in r))throw new Error("Not a valid DSIstudio FIB file");const s="index0"in r&&"index1"in r&&"index2"in r&&"odf_vertices"in r;i.numBitsPerVoxel=32,i.datatypeCode=16,i.dims[1]=r.dimension[0],i.dims[2]=r.dimension[1],i.dims[3]=r.dimension[2],i.dims[4]=1,i.pixDims[1]=r.voxel_size[0],i.pixDims[2]=r.voxel_size[1],i.pixDims[3]=r.voxel_size[2],i.sform_code=1;const n=(i.dims[1]-1)*.5*i.pixDims[1],a=(i.dims[2]-1)*.5*i.pixDims[2],o=(i.dims[3]-1)*.5*i.pixDims[3];i.affine=[[i.pixDims[1],0,0,-n],[0,-i.pixDims[2],0,a],[0,0,i.pixDims[2],-o],[0,0,0,1]],i.littleEndian=!0;const l=i.dims[1]*i.dims[2]*i.dims[3],c=l*Math.ceil(i.numBitsPerVoxel/8),h=c*i.dims[4],d=new Uint8Array(new ArrayBuffer(l*4*3));if(s){const p=i.dims[1]*i.dims[2]*i.dims[3],g=new Float32Array(p),x=new Float32Array(p),A=new Float32Array(p),y=r.index0,v=r.odf_vertices;for(let b=0;b<p;b++){const w=y[b]*3;g[b]=v[w+0],x[b]=v[w+1],A[b]=-v[w+2]}d.set(new Uint8Array(g.buffer,g.byteOffset,g.byteLength),0*c),d.set(new Uint8Array(x.buffer,x.byteOffset,x.byteLength),1*c),d.set(new Uint8Array(A.buffer,A.byteOffset,A.byteLength),2*c)}"report"in r&&(i.description=new TextDecoder().decode(r.report.subarray(0,Math.min(79,r.report.byteLength))));const f=new Uint8Array(new ArrayBuffer(h)),u=Float32Array.from(r.dti_fa);if("mask"in r){let p=1;"dti_fa_slope"in r&&(p=r.dti_fa_slope[0]);let g=1;"dti_fa_inter"in r&&(g=r.dti_fa_inter[0]);const x=i.dims[1]*i.dims[2]*i.dims[3],A=r.mask,y=new Float32Array(x);let v=0;for(let b=0;b<x;b++)A[b]!==0&&(y[b]=u[v]*p+g,v++);return[y.buffer,new Float32Array(d.buffer)]}const m=new Uint8Array(u.buffer,u.byteOffset,u.byteLength);return f.set(m,0),[f.buffer,new Float32Array(d.buffer)]}async function fh(t,e){t.hdr=new G;const i=t.hdr;i.littleEndian=!1,i.dims=[3,1,1,1,0,0,0,0],i.pixDims=[1,1,1,1,1,0,0,0];const r=await H.readMatV4(e);if(!("dimension"in r)||!("image0"in r))throw new Error("Not a valid DSIstudio SRC file");let s=0,n=0;for(const[u,m]of Object.entries(r))if(u.startsWith("image")){if(s===0?n=m.length:n!==m.length&&(n=-1),m.constructor!==Uint16Array)throw new Error("DSIstudio SRC files always use Uint16 datatype");s++}if(n<1||s<1)throw new Error("SRC file not valid DSI Studio data. The image(s) should have the same length");i.numBitsPerVoxel=16,i.datatypeCode=512,i.dims[1]=r.dimension[0],i.dims[2]=r.dimension[1],i.dims[3]=r.dimension[2],i.dims[4]=s,i.dims[4]>1&&(i.dims[0]=4),i.pixDims[1]=r.voxel_size[0],i.pixDims[2]=r.voxel_size[1],i.pixDims[3]=r.voxel_size[2],i.sform_code=1;const a=(i.dims[1]-1)*.5*i.pixDims[1],o=(i.dims[2]-1)*.5*i.pixDims[2],l=(i.dims[3]-1)*.5*i.pixDims[3];i.affine=[[i.pixDims[1],0,0,-a],[0,-i.pixDims[2],0,o],[0,0,i.pixDims[2],-l],[0,0,0,1]],i.littleEndian=!0;const c=i.dims[1]*i.dims[2]*i.dims[3]*(i.numBitsPerVoxel/8),h=c*i.dims[4],d=new Uint8Array(new ArrayBuffer(h));let f=0;for(let u=0;u<s;u++){const m=r[`image${u}`],p=new Uint8Array(m.buffer,m.byteOffset,m.byteLength);d.set(p,f),f+=c}return"report"in r&&(i.description=new TextDecoder().decode(r.report.subarray(0,Math.min(79,r.report.byteLength)))),d.buffer}var ir={};be(ir,{readECAT:()=>uh});function uh(t,e){t.hdr=new G;const i=t.hdr;i.dims=[3,1,1,1,0,0,0,0],i.pixDims=[1,1,1,1,1,0,0,0];const r=new DataView(e),s=r.getInt32(0,!1),n=r.getInt16(50,!1);if(s!==1296127058||n<1||n>14)throw new Error("Not a valid ECAT file");let a=512,o=0;const l=[];let c=new Float32Array;for(;;){const h=r.getInt32(a,!1),d=r.getInt32(a+12,!1);if(h+d!==31)break;let f=a+20,u=0,m=0;for(;u<31&&(m=r.getInt32(f,!1),f+=16,m!==0);){u++;let p=m*512;const g=p-512,x=r.getUint16(g,!1);i.dims[1]=r.getUint16(g+4,!1),i.dims[2]=r.getUint16(g+6,!1),i.dims[3]=r.getUint16(g+8,!1);const A=r.getFloat32(g+26,!1);i.pixDims[1]=r.getFloat32(g+34,!1)*10,i.pixDims[2]=r.getFloat32(g+38,!1)*10,i.pixDims[3]=r.getFloat32(g+42,!1)*10,i.pixDims[4]=r.getUint32(g+46,!1)/1e3,l.push(i.pixDims[4]);const y=i.dims[1]*i.dims[2]*i.dims[3],v=new Float32Array(y);if(x===1)for(let w=0;w<y;w++)v[w]=r.getUint8(p)*A,p++;else if(x===6)for(let w=0;w<y;w++)v[w]=r.getUint16(p,!1)*A,p+=2;else if(x===7)for(let w=0;w<y;w++)v[w]=r.getUint32(p,!1)*A,p+=4;else F.warn("Unknown ECAT data type "+x);const b=c.slice(0);c=new Float32Array(b.length+v.length),c.set(b),c.set(v,b.length),o++}if(m===0)break;a+=512}if(i.dims[4]=o,i.pixDims[4]=l[0],o>1){i.dims[0]=4;let h=!1;for(let d=0;d<o;d++)l[d]!==l[0]&&(h=!0);h&&F.warn("Frame durations vary")}return i.sform_code=1,i.affine=[[-i.pixDims[1],0,0,(i.dims[1]-2)*.5*i.pixDims[1]],[0,-i.pixDims[2],0,(i.dims[2]-2)*.5*i.pixDims[2]],[0,0,-i.pixDims[3],(i.dims[3]-2)*.5*i.pixDims[3]],[0,0,0,1]],i.numBitsPerVoxel=32,i.datatypeCode=16,c.buffer}var ni={};be(ni,{imageDataFromArrayBuffer:()=>Dn,readBMP:()=>mh});async function Dn(t){return new Promise((e,i)=>{const r=new Blob([t]),s=URL.createObjectURL(r),n=new Image;n.crossOrigin="Anonymous",n.src=s,n.onload=()=>{URL.revokeObjectURL(s);const a=document.createElement("canvas");a.width=n.width,a.height=n.height;const o=a.getContext("2d");if(!o){i(new Error("Failed to get 2D context"));return}o.drawImage(n,0,0),e(o.getImageData(0,0,n.width,n.height))},n.onerror=a=>{URL.revokeObjectURL(s),i(a)}})}async function mh(t,e){const i=await Dn(e),{width:r,height:s,data:n}=i;t.hdr=new G;const a=t.hdr;a.dims=[3,r,s,1,0,0,0,0],a.pixDims=[1,1,1,1,1,0,0,0],a.affine=[[a.pixDims[1],0,0,-(a.dims[1]-2)*.5*a.pixDims[1]],[0,-a.pixDims[2],0,(a.dims[2]-2)*.5*a.pixDims[2]],[0,0,-a.pixDims[3],(a.dims[3]-2)*.5*a.pixDims[3]],[0,0,0,1]],a.numBitsPerVoxel=8,a.datatypeCode=2304;let o=!0;for(let l=0;l<n.length;l+=4)if(n[l]!==n[l+1]||n[l]!==n[l+2]){o=!1;break}if(o){a.datatypeCode=2;const l=new Uint8Array(r*s);for(let c=0,h=0;c<n.length;c+=4,h++)l[h]=n[c];return l.buffer}return n.buffer}var rr={};be(rr,{readMHA:()=>ph});async function ph(t,e,i){const r=e.byteLength;if(r<20)throw new Error("File too small to be VTK: bytes = "+e.byteLength);const s=new Uint8Array(e);let n=0;function a(p){return p===10||p===13}function o(){for(;n<r&&a(s[n]);)n++;const p=n;for(;n<r&&!a(s[n]);)n++;return n-p<2?"":new TextDecoder().decode(e.slice(p,n))}let l=o();t.hdr=new G;const c=t.hdr;c.pixDims=[1,1,1,1,1,0,0,0],c.dims=[1,1,1,1,1,1,1,1],c.littleEndian=!0;let h=!1,d=!1;const f=He(NaN,0,0,0,1,0,0,0,1),u=k(0,0,0);for(;l!=="";){let p=l.split(" ");if(p.length>2&&(p=p.slice(2)),l.startsWith("BinaryDataByteOrderMSB")&&p[0].includes("False")&&(c.littleEndian=!0),l.startsWith("BinaryDataByteOrderMSB")&&p[0].includes("True")&&(c.littleEndian=!1),l.startsWith("CompressedData")&&p[0].includes("True")&&(h=!0),l.startsWith("TransformMatrix"))for(let g=0;g<9;g++)f[g]=parseFloat(p[g]);if(l.startsWith("Offset"))for(let g=0;g<Math.min(p.length,3);g++)u[g]=parseFloat(p[g]);if(l.startsWith("ElementSpacing"))for(let g=0;g<p.length;g++)c.pixDims[g+1]=parseFloat(p[g]);if(l.startsWith("DimSize")){c.dims[0]=p.length;for(let g=0;g<p.length;g++)c.dims[g+1]=parseInt(p[g])}if(l.startsWith("ElementType"))switch(p[0]){case"MET_UCHAR":c.numBitsPerVoxel=8,c.datatypeCode=2;break;case"MET_CHAR":c.numBitsPerVoxel=8,c.datatypeCode=256;break;case"MET_SHORT":c.numBitsPerVoxel=16,c.datatypeCode=4;break;case"MET_USHORT":c.numBitsPerVoxel=16,c.datatypeCode=512;break;case"MET_INT":c.numBitsPerVoxel=32,c.datatypeCode=8;break;case"MET_UINT":c.numBitsPerVoxel=32,c.datatypeCode=768;break;case"MET_FLOAT":c.numBitsPerVoxel=32,c.datatypeCode=16;break;case"MET_DOUBLE":c.numBitsPerVoxel=64,c.datatypeCode=64;break;default:throw new Error("Unsupported MHA data type: "+p[0])}if(l.startsWith("ObjectType")&&!p[0].includes("Image")&&F.warn("Only able to read ObjectType = Image, not "+l),l.startsWith("ElementDataFile")){p[0]!=="LOCAL"&&(d=!0);break}l=o()}const m=He(c.pixDims[1],0,0,0,c.pixDims[2],0,0,0,c.pixDims[3]);for(Hs(f,f,m),c.affine=[[-f[0],-f[3],-f[6],-u[0]],[-f[1],-f[4],-f[7],-u[1]],[f[2],f[5],f[8],u[2]],[0,0,0,1]];s[n]===10;)n++;return c.vox_offset=n,d&&i?h?await H.decompressToBuffer(new Uint8Array(i.slice(0))):i.slice(0):h?await H.decompressToBuffer(new Uint8Array(e.slice(c.vox_offset))):e.slice(c.vox_offset)}var Tn={};be(Tn,{isFreeSurferLabelImage:()=>En,optimizeFreeSurferLabels:()=>Sn,readMgh:()=>gh});function ps(t,e,i,r=1){const s=e+i;let n=e;const a=[];for(;n+12<=s;){const o=t.getInt32(n,!1),l=t.getInt32(n+8,!1);if(n+=12,l<=0||n+l>s)break;if(o!==r){n+=l;continue}let c=l,h=n;if(r===1){if(n+4>s)break;c=t.getInt32(n,!1),h+=4}if(c>1&&h+c<=s){const d=new Uint8Array(t.buffer,h,c),f=new TextDecoder("utf-8").decode(d.slice(0,-1));a.push(f)}n+=l}return a.join(`
+
+`)}function Sn(t,e){if(t.intent_code=1002,t.datatypeCode!==16&&t.datatypeCode!==8)return e;let i=new Float32Array(e);if(t.datatypeCode===8&&(i=new Int32Array(e)),er()){const a=new Uint32Array(e);for(let o=0;o<a.length;o++){const l=a[o];a[o]=(l&255)<<24|(l&65280)<<8|(l&16711680)>>>8|(l&4278190080)>>>24}}t.littleEndian=er();let r=!0,s=1/0,n=-1/0;for(let a=0;a<i.length;a++){const o=i[a];Number.isFinite(o)&&(Number.isInteger(o)||(r=!1),o<s&&(s=o),o>n&&(n=o))}if(!r||s<0||n>2147483647)return F.warn(`FreeSurfer Labels must be integers in INT32 range. range ${s}..${n}`),e;if(n>32767){t.datatypeCode=8;const a=new Int32Array(i.length);for(let o=0;o<i.length;o++)a[o]=Math.trunc(i[o]);return a.buffer}else if(n>255){t.datatypeCode=4,t.numBitsPerVoxel=16;const a=new Int16Array(i.length);for(let o=0;o<i.length;o++)a[o]=Math.trunc(i[o]);return a.buffer}else{t.datatypeCode=2,t.numBitsPerVoxel=8;const a=new Uint8Array(i.length);for(let o=0;o<i.length;o++)a[o]=Math.trunc(i[o]);return a.buffer}}function En(t,e,i){const r=t.byteLength-e.vox_offset;if(r<i)return F.error(`MGH image data size mismatch: expected ${i}, found ${r}`),!1;if(r===i)return!1;const s=e.vox_offset+i+20,n=t.byteLength-s;return n<=12?!1:ps(new DataView(t),s,n).toLowerCase().endsWith("lut.txt")?!0:ps(new DataView(t),s,n,3).includes("mri_label2vol")}async function gh(t,e,i=""){t.hdr||(F.debug("readMgh called before nvImage.hdr was initialized. Creating default."),t.hdr=new G);const r=t.hdr;r.littleEndian=!1;let s=e,n=new DataView(s);if(s.byteLength>=2&&n.getUint8(0)===31&&n.getUint8(1)===139)try{s=await H.decompressToBuffer(new Uint8Array(e)),n=new DataView(s)}catch(N){return F.error("Failed to decompress MGZ file.",N),null}if(s.byteLength<284)return F.error("File too small to be a valid MGH/MGZ header."),null;const a=n.getInt32(0,!1),o=n.getInt32(4,!1),l=n.getInt32(8,!1),c=n.getInt32(12,!1),h=n.getInt32(16,!1),d=n.getInt32(20,!1),f=n.getFloat32(30,!1),u=n.getFloat32(34,!1),m=n.getFloat32(38,!1),p=n.getFloat32(42,!1),g=n.getFloat32(46,!1),x=n.getFloat32(50,!1),A=n.getFloat32(54,!1),y=n.getFloat32(58,!1),v=n.getFloat32(62,!1),b=n.getFloat32(66,!1),w=n.getFloat32(70,!1),C=n.getFloat32(74,!1),M=n.getFloat32(78,!1),T=n.getFloat32(82,!1),E=n.getFloat32(86,!1);if(a!==1&&a!==257&&F.warn(`Unexpected MGH version: ${a}.`),o<=0||l<=0||c<=0)return F.error(`Invalid MGH dimensions: ${o}x${l}x${c}`),null;switch(d){case 0:r.numBitsPerVoxel=8,r.datatypeCode=2;break;case 4:r.numBitsPerVoxel=16,r.datatypeCode=4;break;case 1:r.numBitsPerVoxel=32,r.datatypeCode=8;break;case 3:r.numBitsPerVoxel=32,r.datatypeCode=16;break;default:return F.error(`Unsupported MGH data type: ${d}`),null}r.dims[1]=o,r.dims[2]=l,r.dims[3]=c,r.dims[4]=Math.max(1,h),r.dims[0]=r.dims[4]>1?4:3,r.pixDims[0]=1,r.pixDims[1]=Math.abs(f),r.pixDims[2]=Math.abs(u),r.pixDims[3]=Math.abs(m),r.pixDims[4]=0,r.sform_code=1,r.qform_code=0,r.sform_code=1;const I=Ee(p*r.pixDims[1],A*r.pixDims[2],b*r.pixDims[3],0,g*r.pixDims[1],y*r.pixDims[2],w*r.pixDims[3],0,x*r.pixDims[1],v*r.pixDims[2],C*r.pixDims[3],0,0,0,0,1),S=[r.dims[1]/2,r.dims[2]/2,r.dims[3]/2,1],U=[0,0,0,0];for(let N=0;N<3;N++){U[N]=0;for(let Y=0;Y<3;Y++)U[N]=U[N]+I[Y+N*4]*S[Y]}r.affine=[[I[0],I[1],I[2],M-U[0]],[I[4],I[5],I[6],T-U[1]],[I[8],I[9],I[10],E-U[2]],[0,0,0,1]],r.vox_offset=284,r.magic="n+1";const B=r.numBitsPerVoxel/8,R=o*l*c*r.dims[4]*B,P=s.slice(r.vox_offset,r.vox_offset+R);let L=a===257;return L||(L=["aparc.DKTatlas+aseg.deep.mg","aparc+aseg.mg","aparc.DKTatlas+aseg.mg","aparc.a2005s+aseg.mg","aparc.a2009s+aseg.mg","apas+head.mg","apas+head.samseg.mg","aseg.auto.mg","aseg.auto_noCCseg.mg","aseg.mg","aseg.presurf.hypos.mg","aseg.presurf.mg","brainstemSsLabels.v13.FSvoxelSpace.mg","brainstemSsLabels.v13.mg","ctrl_pts.mg","filled.auto.mg","filled.mg","gtmseg.mg","hypothalamic_subunits_seg.v1.mg","lh.hippoAmygLabels-T1.v22.CA.FSvoxelSpace.mg","lh.hippoAmygLabels-T1.v22.CA.mg","lh.hippoAmygLabels-T1.v22.FS60.FSvoxelSpace.mg","lh.hippoAmygLabels-T1.v22.FS60.mg","lh.hippoAmygLabels-T1.v22.FSvoxelSpace.mg","lh.hippoAmygLabels-T1.v22.HBT.FSvoxelSpace.mg","lh.hippoAmygLabels-T1.v22.HBT.mg","lh.hippoAmygLabels-T1.v22.mg","lh.ribbon.mg","mca-dura.mg","rh.hippoAmygLabels-T1.v22.CA.FSvoxelSpace.mg","rh.hippoAmygLabels-T1.v22.CA.mg","rh.hippoAmygLabels-T1.v22.FS60.FSvoxelSpace.mg","rh.hippoAmygLabels-T1.v22.FS60.mg","rh.hippoAmygLabels-T1.v22.FSvoxelSpace.mg","rh.hippoAmygLabels-T1.v22.HBT.FSvoxelSpace.mg","rh.hippoAmygLabels-T1.v22.HBT.mg","rh.hippoAmygLabels-T1.v22.mg","rh.ribbon.mg","ribbon.mg","synthseg.mg","synthseg.rca.mg","vsinus.mg","subcort.mask.1mm.mg","subcort.mask.mg","surface.defects.mg","ThalamicNuclei.v13.T1.FSvoxelSpace.mg","ThalamicNuclei.v13.T1.mg","wm.asegedit.mg","wmparc.mg"].some(Y=>i.includes(Y))),L||(L=En(s,r,R)),L?Sn(r,P):P}var sr={};be(sr,{readMIF:()=>Ah});async function Ah(t,e,i){t.hdr=new G;const r=t.hdr;r.pixDims=[1,1,1,1,1,0,0,0],r.dims=[1,1,1,1,1,1,1,1];let s=e.byteLength;if(s<20)throw new Error("File too small to be MIF: bytes = "+s);let n=new Uint8Array(e);n[0]===31&&n[1]===139&&(F.debug("MIF with GZ decompression"),e=await H.decompressToBuffer(new Uint8Array(e)),s=e.byteLength,n=new Uint8Array(e));let a=0;function o(){for(;a<s&&n[a]===10;)a++;const S=a;for(;a<s&&n[a]!==10;)a++;return a++,a-S<1?"":new TextDecoder().decode(e.slice(S,a-1))}let l=o();if(!l.startsWith("mrtrix image"))throw new Error("Not a valid MIF file");const c=[];let h=!1,d=0,f=0,u=!1;for(l=o();a<s&&!l.startsWith("END");){let S=l.split(":");if(l=o(),S.length<2)break;const U=S[0];S=S[1].split(",");for(let B=0;B<S.length;B++)S[B]=S[B].trim();switch(U){case"dim":r.dims[0]=S.length;for(let B=0;B<S.length;B++)r.dims[B+1]=parseInt(S[B]);break;case"vox":for(let B=0;B<S.length;B++)r.pixDims[B+1]=parseFloat(S[B]),isNaN(r.pixDims[B+1])&&(r.pixDims[B+1]=0);break;case"layout":for(let B=0;B<S.length;B++)c.push(parseInt(S[B]));break;case"datatype":{const B=S[0];B.startsWith("Bit")?(h=!0,r.datatypeCode=2):B.startsWith("Int8")?r.datatypeCode=256:B.startsWith("UInt8")?r.datatypeCode=2:B.startsWith("Int16")?r.datatypeCode=4:B.startsWith("UInt16")?r.datatypeCode=512:B.startsWith("Int32")?r.datatypeCode=8:B.startsWith("UInt32")?r.datatypeCode=768:B.startsWith("Float32")?r.datatypeCode=16:B.startsWith("Float64")?r.datatypeCode=64:F.warn("Unsupported datatype "+B),B.includes("8")?r.numBitsPerVoxel=8:B.includes("16")?r.numBitsPerVoxel=16:B.includes("32")?r.numBitsPerVoxel=32:B.includes("64")&&(r.numBitsPerVoxel=64),r.littleEndian=!0,B.endsWith("LE")&&(r.littleEndian=!0),B.endsWith("BE")&&(r.littleEndian=!1)}break;case"transform":if(d>2||S.length!==4)break;r.affine[d][0]=parseFloat(S[0]),r.affine[d][1]=parseFloat(S[1]),r.affine[d][2]=parseFloat(S[2]),r.affine[d][3]=parseFloat(S[3]),d++;break;case"comments":r.description=S[0].substring(0,Math.min(79,S[0].length));break;case"RepetitionTime":f=parseFloat(S[0]);break;case"file":u=!S[0].startsWith(". "),u||(S=S[0].split(" "),r.vox_offset=parseInt(S[1]));break}}const m=r.dims[0];m>5&&F.warn("reader only designed for a maximum of 5 dimensions (XYZTD)");let p=1;for(let S=0;S<m;S++)p*=Math.max(r.dims[S+1],1);for(let S=0;S<3;S++)for(let U=0;U<3;U++)r.affine[S][U]*=r.pixDims[U+1];F.debug("mif affine:"+r.affine[0]),f>0&&(r.pixDims[4]=f),u&&!i&&F.warn("MIH header provided without paired image data");let g;if(i&&u)g=i.slice(0);else if(h){r.numBitsPerVoxel=8;const S=new Uint8Array(p),U=e.slice(r.vox_offset,r.vox_offset+Math.ceil(p/8)),B=new Uint8Array(U);let V=0;for(let R=0;R<p;R++){const P=R%8;S[R]=B[V]>>7-P&1,P===7&&V++}g=S.buffer}else g=e.slice(r.vox_offset,r.vox_offset+p*(r.numBitsPerVoxel/8));c.length!==r.dims[0]&&F.warn("dims does not match layout");let x=1;const A=[1,1,1,1,1],y=[!1,!1,!1,!1,!1];for(let S=0;S<c.length;S++)for(let U=0;U<c.length;U++)Math.abs(c[U])===S&&(A[U]=x,(c[U]<0||Object.is(c[U],-0))&&(y[U]=!0),x*=r.dims[U+1]);let v=H.range(0,r.dims[1]-1,1);y[0]&&(v=H.range(r.dims[1]-1,0,-1));for(let S=0;S<r.dims[1];S++)v[S]*=A[0];let b=H.range(0,r.dims[2]-1,1);y[1]&&(b=H.range(r.dims[2]-1,0,-1));for(let S=0;S<r.dims[2];S++)b[S]*=A[1];let w=H.range(0,r.dims[3]-1,1);y[2]&&(w=H.range(r.dims[3]-1,0,-1));for(let S=0;S<r.dims[3];S++)w[S]*=A[2];let C=H.range(0,r.dims[4]-1,1);y[3]&&(C=H.range(r.dims[4]-1,0,-1));for(let S=0;S<r.dims[4];S++)C[S]*=A[3];let M=H.range(0,r.dims[5]-1,1);y[4]&&(M=H.range(r.dims[5]-1,0,-1));for(let S=0;S<r.dims[5];S++)M[S]*=A[4];let T=0,E,I;switch(r.datatypeCode){case 256:E=new Int8Array(g),I=new Int8Array(p);break;case 2:E=new Uint8Array(g),I=new Uint8Array(p);break;case 4:E=new Int16Array(g),I=new Int16Array(p);break;case 512:E=new Uint16Array(g),I=new Uint16Array(p);break;case 8:E=new Int32Array(g),I=new Int32Array(p);break;case 768:E=new Uint32Array(g),I=new Uint32Array(p);break;case 16:E=new Float32Array(g),I=new Float32Array(p);break;case 64:E=new Float64Array(g),I=new Float64Array(p);break;default:throw new Error("unknown datatypeCode")}for(let S=0;S<r.dims[5];S++)for(let U=0;U<r.dims[4];U++)for(let B=0;B<r.dims[3];B++)for(let V=0;V<r.dims[2];V++)for(let R=0;R<r.dims[1];R++)I[T]=E[v[R]+b[V]+w[B]+C[U]+M[S]],T++;return I.buffer}var In={};be(In,{readNifti:()=>xh});async function xh(t,e,i){let r=e,s=null;try{if(pr(r)&&(F.debug(`Decompressing NIfTI file: ${t.name}`),r=await lo(r),F.debug(`Decompression complete for: ${t.name}`)),!r||r.byteLength===0)throw new Error("Buffer became invalid after decompression attempt.");if(t.hdr=await Nt(r,i!=null),ho(t.hdr)&&(t.extensions=t.hdr.extensions),t.hdr===null)throw new Error(`Failed to read NIfTI header: ${t.name}`);if(t.hdr.cal_min===0&&t.hdr.cal_max===255&&t.hdr.datatypeCode!==2&&(F.debug(`Resetting suspicious cal_min/max (0/255) for non-uint8 NIfTI: ${t.name}`),t.hdr.cal_min=0,t.hdr.cal_max=0),s=i?Jr(t.hdr,i):Jr(t.hdr,r),s===null)throw new Error(`nifti-reader-js readImage returned null for ${t.name}`);return s}catch(n){return F.error(`Error processing NIfTI file ${t.name}:`,n),t.hdr=null,null}}var Fn={};be(Fn,{readNrrd:()=>vh});async function vh(t,e,i=null){t.hdr||(F.warn("readNrrd called before nvImage.hdr was initialized. Creating default."),t.hdr=new G);const r=t.hdr;r.pixDims=[1,1,1,1,1,0,0,0],r.dims=[0,0,0,0,0,0,0,0];const s=e.byteLength;let n=null;const a=new Uint8Array(e);for(let w=1;w<s;w++)if(a[w-1]===10&&a[w]===10){const C=e.slice(0,w-1);n=new TextDecoder().decode(C),r.vox_offset=w+1;break}if(n===null)return F.error("readNrrd: could not extract txt"),null;const o=n.split(`
+`);if(!o[0].startsWith("NRRD"))return F.error("Invalid NRRD image (magic signature missing)"),null;const l=o.length;let c=!1,h=!1,d=!1;const f=He(NaN,0,0,0,1,0,0,0,1),u=k(0,0,0);let m=qi();for(let w=1;w<l;w++){let C=o[w];if((C.length===0||C[0]==="#")&&(C.startsWith("#")||C.trim().length===0))continue;C=C.toLowerCase();const M=C.split(":");if(M.length<2)continue;const T=M[0].trim();let E=M[1].trim();switch(E=E.replaceAll(")"," "),E=E.replaceAll("("," "),E=E.trim(),T){case"data file":d=!0;break;case"encoding":if(E.includes("raw"))c=!1;else if(E.includes("gz"))c=!0;else return F.error(`Unsupported NRRD encoding : ${E}`),null;break;case"type":switch(E){case"uchar":case"unsigned char":case"uint8":case"uint8_t":r.numBitsPerVoxel=8,r.datatypeCode=2;break;case"signed char":case"int8":case"int8_t":r.numBitsPerVoxel=8,r.datatypeCode=256;break;case"short":case"short int":case"signed short":case"signed short int":case"int16":case"int16_t":r.numBitsPerVoxel=16,r.datatypeCode=4;break;case"ushort":case"unsigned short":case"unsigned short int":case"uint16":case"uint16_t":r.numBitsPerVoxel=16,r.datatypeCode=512;break;case"int":case"signed int":case"int32":case"int32_t":r.numBitsPerVoxel=32,r.datatypeCode=8;break;case"uint":case"unsigned int":case"uint32":case"uint32_t":r.numBitsPerVoxel=32,r.datatypeCode=768;break;case"float":r.numBitsPerVoxel=32,r.datatypeCode=16;break;case"double":r.numBitsPerVoxel=64,r.datatypeCode=64;break;default:return F.error("Unsupported NRRD data type: "+E),null}break;case"spacings":{const I=E.split(/[ ,]+/);for(let S=0;S<I.length;S++)r.pixDims[S+1]=parseFloat(I[S])}break;case"sizes":{const I=E.split(/[ ,]+/);r.dims[0]=I.length;for(let S=0;S<I.length;S++)r.dims[S+1]=parseInt(I[S])}break;case"endian":E.includes("little")?r.littleEndian=!0:E.includes("big")&&(r.littleEndian=!1);break;case"space directions":{const I=E.split(/[ ,]+/);if(I.length===9)for(let S=0;S<9;S++)f[S]=parseFloat(I[S])}break;case"space origin":{const I=E.split(/[ ,]+/);I.length===3&&(u[0]=parseFloat(I[0]),u[1]=parseFloat(I[1]),u[2]=parseFloat(I[2]))}break;case"space units":E.includes("microns")&&(h=!0);break;case"space":E.includes("right-anterior-superior")||E.includes("ras")?m=He(1,0,0,0,1,0,0,0,1):E.includes("left-anterior-superior")||E.includes("las")?m=He(-1,0,0,0,1,0,0,0,1):E.includes("left-posterior-superior")||E.includes("lps")?m=He(-1,0,0,0,-1,0,0,0,1):F.warn("Unsupported NRRD space value:",E);break;default:F.warn("Unknown:",T);break}}if(!isNaN(f[0])){r.sform_code=2,h&&(Ta(f,f,.001),u[0]*=.001,u[1]*=.001,u[2]*=.001),m[0]<0&&(u[0]=-u[0]),m[4]<0&&(u[1]=-u[1]),m[8]<0&&(u[2]=-u[2]),Hs(f,m,f);const w=Ee(f[0],f[3],f[6],u[0],f[1],f[4],f[7],u[1],f[2],f[5],f[8],u[2],0,0,0,1);if(!t.vox2mm)return null;const C=t.vox2mm([0,0,0],w),M=t.vox2mm([1,0,0],w);ne(M,M,C);const T=t.vox2mm([0,1,0],w);ne(T,T,C);const E=t.vox2mm([0,0,1],w);ne(E,E,C),r.pixDims[0]=1,r.pixDims[1]=Qe(M),r.pixDims[2]=Qe(T),r.pixDims[3]=Qe(E),r.affine=[[w[0],w[1],w[2],w[3]],[w[4],w[5],w[6],w[7]],[w[8],w[9],w[10],w[11]],[0,0,0,1]]}let p=null;const g=d?i:e,x=d?0:r.vox_offset;if(d&&!g)return F.warn("Missing data: NRRD header describes detached data file but only one URL provided"),null;if(!g||x>=g.byteLength)return F.error(`NRRD data offset (${x}) invalid for buffer length (${g?.byteLength??0})`),null;let A=g.slice(x);if(c)try{F.debug("Decompressing NRRD data..."),A=await H.decompressToBuffer(new Uint8Array(A)),F.debug("Decompression complete.")}catch(w){return F.error("Failed to decompress NRRD data.",w),null}const y=r.numBitsPerVoxel/8,b=r.dims.slice(1,r.dims[0]+1).reduce((w,C)=>w*Math.max(1,C),1)*y;return A.byteLength<b?(F.error(`NRRD image data size mismatch: expected ${b}, found ${A.byteLength}`),null):(A.byteLength>b&&(F.warn(`NRRD has extra ${A.byteLength-b} bytes after expected image data. Truncating.`),A=A.slice(0,b)),p=A,r.datatypeCode?r.numBitsPerVoxel?p:(F.error("NRRD parsing failed to set numBitsPerVoxel."),null):(F.error("NRRD parsing failed to set datatypeCode."),null))}var Dt={};be(Dt,{readNPY:()=>Bn,readNPZ:()=>bh});function wh(t){if(t.length<2)throw new Error(`Invalid NPY dtype: ${t}`);const e=t.slice(1),r={b1:1,i1:1,u1:1,i2:2,u2:2,i4:4,u4:4,f4:4,f8:8}[e];if(r===void 0)throw new Error(`Unsupported NPY dtype: ${t}`);return r}function yh(t){if(t.length<2)throw new Error(`Invalid NPY dtype: ${t}`);const e=t.slice(1),r={b1:2,i1:256,u1:2,i2:4,u2:512,i4:8,u4:768,f4:16,f8:64}[e];if(r===void 0)throw new Error(`Unsupported NPY dtype: ${t}`);return r}async function Bn(t,e){const i=new DataView(e),r=[i.getUint8(0),i.getUint8(1),i.getUint8(2),i.getUint8(3),i.getUint8(4),i.getUint8(5)],s=[147,78,85,77,80,89];if(!r.every((U,B)=>U===s[B]))throw new Error("Not a valid NPY file: Magic number mismatch");const n=i.getUint8(6),a=i.getUint8(7);let o,l,c;if(n===1)o=i.getUint16(8,!0),l=10,c="latin1";else if(n===2||n===3)o=i.getUint32(8,!0),l=12,c=n===3?"utf-8":"latin1";else throw new Error(`Unsupported NPY version: ${n}.${a}`);const h=l+o;if(h>e.byteLength)throw new Error("Invalid NPY file: Header length exceeds buffer size");const d=new TextDecoder(c).decode(e.slice(l,h)),f=d.match(/'shape': \((.*?)\)/);if(!f)throw new Error("Invalid NPY header: Shape not found");const u=f[1].split(",").map(U=>U.trim()).filter(U=>U!=="").map(Number);if(u.length===0||u.some(U=>!Number.isInteger(U)||U<=0))throw new Error(`Invalid NPY header: invalid shape (${f[1]})`);if(u.length<2||u.length>4)throw new Error(`Unsupported NPY shape: expected 2D, 3D, or 4D array, got (${u.join(", ")})`);const m=d.match(/'descr': '([^']+)'/);if(!m)throw new Error("Invalid NPY header: Data type not found");const p=m[1],g=p[0],x=new Uint8Array(new Uint16Array([1]).buffer)[0]===1;if(!["<",">","|","="].includes(g))throw new Error(`Invalid NPY dtype endian prefix: ${p}`);const A=u.reduce((U,B)=>U*B,1),y=wh(p),v=A*y;if(e.byteLength-h<v)throw new Error("Invalid .npy file: not enough data bytes for specified shape and data type");const w=e.slice(h,h+v),C=u.length,M=u[u.length-1],T=u[u.length-2],E=u.length>=3?u[u.length-3]:1,I=u.length===4?u[0]:1;t.hdr=new G;const S=t.hdr;return S.dims=[C,M,T,E,I,1,1,1],S.pixDims=[1,1,1,1,1,1,1,1],S.affine=[[S.pixDims[1],0,0,-(S.dims[1]-2)*.5*S.pixDims[1]],[0,-S.pixDims[2],0,(S.dims[2]-2)*.5*S.pixDims[2]],[0,0,-S.pixDims[3],(S.dims[3]-2)*.5*S.pixDims[3]],[0,0,0,1]],S.numBitsPerVoxel=y*8,S.datatypeCode=yh(p),S.littleEndian=g==="<"||g==="|"||g==="="&&x,w}async function bh(t,e){const i=new An(e);for(let r=0;r<i.entries.length;r++){const s=i.entries[r];if(s.fileName.toLowerCase().endsWith(".npy")){const n=await s.extract(),a=n.buffer.slice(n.byteOffset,n.byteOffset+n.byteLength);return await Bn(t,a)}}}var nr={};be(nr,{readZARR:()=>Mh});function Ch(t,e,i,r){const s=e*i,n=new Uint8Array(s*r*3),a=new Array(r);for(let c=0;c<r;c++)a[c]=s*3*c;let o=0,l=0;for(let c=0;c<s;c++){for(let h=0;h<r;h++)n[a[h]+l]=t[o++],n[a[h]+l+1]=t[o++],n[a[h]+l+2]=t[o++];l+=3}return n}async function Mh(t,e,i){let{width:r,height:s,depth:n=1,data:a}=i??{},o=r*s*n*3,l=o===a.length;if(l||(o=r*s*n,n===3&&(l=!0,n=1)),o!==a.length)throw new Error(`Expected RGB ${r}×${s}×${n}×3 =  ${o}, but ZARR length ${a.length}`);t.hdr=new G;const c=t.hdr;if(c.dims=[3,r,s,n,1,1,1,1],c.pixDims=[1,1,1,1,0,0,0,0],c.affine=[[c.pixDims[1],0,0,-(c.dims[1]-2)*.5*c.pixDims[1]],[0,-c.pixDims[2],0,(c.dims[2]-2)*.5*c.pixDims[2]],[0,0,-c.pixDims[3],(c.dims[3]-2)*.5*c.pixDims[3]],[0,0,0,1]],!l){if(c.numBitsPerVoxel=8,c.datatypeCode=2,a instanceof Uint8Array){const u=new ArrayBuffer(a.length);return new Uint8Array(u).set(a),u}return a}c.numBitsPerVoxel=24,c.datatypeCode=128;const h=Ch(a,c.dims[1],c.dims[2],c.dims[3]),d=new ArrayBuffer(h.length);return new Uint8Array(d).set(h),d}function Ge(t,e,i){const r=de(i);Te(r,r);const s=ae(e[0],e[1],e[2],1);return ve(s,s,r),k(s[0],s[1],s[2])}function Un(t,e,i=!1){if(!t.matRAS)throw new Error("matRAS undefined");const r=de(t.matRAS),s=de(r);Te(s,r),Se(s,s);const n=ae(e[0],e[1],e[2],1);ve(n,n,s);const a=k(n[0],n[1],n[2]);return i?a:new Float32Array([Math.round(a[0]),Math.round(a[1]),Math.round(a[2])])}function Dh(t,e){return k((e[0]+.5)/t.dimsRAS[1],(e[1]+.5)/t.dimsRAS[2],(e[2]+.5)/t.dimsRAS[3])}function Th(t,e){return k(Math.round(e[0]*t.dims[1]-.5),Math.round(e[1]*t.dims[2]-.5),Math.round(e[2]*t.dims[3]-.5))}function Sh(t,e,i=!1){const r=ae(e[0],e[1],e[2],1);return i?ve(r,r,t.frac2mm):ve(r,r,t.frac2mmOrtho),r}function Eh(t,e,i=!1){const r=ae(e[0],e[1],e[2],1),s=t.dimsRAS,n=k(0,0,0);if(typeof s>"u")return n;if(!i){const o=de(t.frac2mmOrtho);return Se(o,o),ve(r,r,o),n[0]=r[0],n[1]=r[1],n[2]=r[2],n}if(s[1]<1||s[2]<1||s[3]<1)return n;const a=de(t.matRAS);return Se(a,a),Te(a,a),ve(r,r,a),n[0]=(r[0]+.5)/s[1],n[1]=(r[1]+.5)/s[2],n[2]=(r[2]+.5)/s[3],n}function ar(t,e){return Array.isArray(t)&&Array.isArray(e)&&t.length===e.length&&t.every((i,r)=>i===e[r])}function Rn(t){const e=de(t);Te(e,t);const i=Math.sqrt(e[0]*e[0]+e[1]*e[1]+e[2]*e[2]),r=Math.max(Math.max(Math.abs(e[0]),Math.abs(e[1])),Math.abs(e[2]))/i,s=Math.sqrt(e[4]*e[4]+e[5]*e[5]+e[6]*e[6]),n=Math.max(Math.max(Math.abs(e[4]),Math.abs(e[5])),Math.abs(e[6]))/s,a=Math.sqrt(e[8]*e[8]+e[9]*e[9]+e[10]*e[10]),o=Math.max(Math.max(Math.abs(e[8]),Math.abs(e[9])),Math.abs(e[10]))/a,l=Math.min(Math.min(r,n),o);let c=Math.abs(Math.acos(l)*180/3.141592653);return c>.01?F.warn("Warning voxels not aligned with world space: "+c+` degrees from plumb.
+`):c=0,c}function or(t){if(!t.matRAS)throw new Error("matRAS not defined");if(t.pixDimsRAS===void 0)throw new Error("pixDimsRAS not defined");if(!t.dimsRAS)throw new Error("dimsRAS not defined");t.oblique_angle=Rn(t.matRAS);const e=Ge(t,[0,0,0],t.matRAS),i=Ge(t,[1/t.pixDimsRAS[1],0,0],t.matRAS),r=Ge(t,[0,1/t.pixDimsRAS[2],0],t.matRAS),s=Ge(t,[0,0,1/t.pixDimsRAS[3]],t.matRAS);ne(i,i,e),ne(r,r,e),ne(s,s,e);const n=Ee(i[0],i[1],i[2],0,r[0],r[1],r[2],0,s[0],s[1],s[2],0,0,0,0,1);t.obliqueRAS=de(n);const a=Math.abs(90-Di(i,r)*(180/Math.PI)),o=Math.abs(90-Di(i,s)*(180/Math.PI)),l=Math.abs(90-Di(r,s)*(180/Math.PI));t.maxShearDeg=Math.max(Math.max(a,o),l),t.maxShearDeg>.1&&F.warn("Warning: voxels are rhomboidal, maximum shear is %f degrees.",t.maxShearDeg);const c=ae(t.dimsRAS[1],t.dimsRAS[2],t.dimsRAS[3],1),h=de(t.matRAS);Te(h,h);const d=ae(-.5,-.5,-.5,0);tt(h,h,k(d[0],d[1],d[2])),h[0]*=c[0],h[1]*=c[0],h[2]*=c[0],h[4]*=c[1],h[5]*=c[1],h[6]*=c[1],h[8]*=c[2],h[9]*=c[2],h[10]*=c[2],t.frac2mm=de(h);const f=t.pixDimsRAS[1],u=t.pixDimsRAS[2],m=t.pixDimsRAS[3],p=de(h);p[0]=f*c[0],p[1]=0,p[2]=0,p[4]=0,p[5]=u*c[1],p[6]=0,p[8]=0,p[9]=0,p[10]=m*c[2];const g=Un(t,[0,0,0],!0);p[12]=(-g[0]-.5)*f,p[13]=(-g[1]-.5)*u,p[14]=(-g[2]-.5)*m,t.frac2mmOrtho=de(p),t.extentsMinOrtho=[p[12],p[13],p[14]],t.extentsMaxOrtho=[p[0]+p[12],p[5]+p[13],p[10]+p[14]],t.mm2ortho=J(),Se(t.mm2ortho,n)}function Ih(t){if(!t.hdr)throw new Error("hdr not set");const e=t.hdr.affine,i=t.hdr,r=He(Math.abs(e[0][0]),Math.abs(e[0][1]),Math.abs(e[0][2]),Math.abs(e[1][0]),Math.abs(e[1][1]),Math.abs(e[1][2]),Math.abs(e[2][0]),Math.abs(e[2][1]),Math.abs(e[2][2])),s=[1,1,1];r[3]>r[0]&&(s[0]=2),r[6]>r[0]&&r[6]>r[3]&&(s[0]=3),s[1]=1,s[0]===1?r[4]>r[7]?s[1]=2:s[1]=3:s[0]===2?r[1]>r[7]?s[1]=1:s[1]=3:r[1]>r[4]?s[1]=1:s[1]=2,s[2]=6-s[1]-s[0];let n=[1,2,3];n[s[0]-1]=1,n[s[1]-1]=2,n[s[2]-1]=3;let a=Ee(e[0][0],e[0][1],e[0][2],e[0][3],e[1][0],e[1][1],e[1][2],e[1][3],e[2][0],e[2][1],e[2][2],e[2][3],0,0,0,1);t.mm000=Ge(t,[-.5,-.5,-.5],a),t.mm100=Ge(t,[i.dims[1]-.5,-.5,-.5],a),t.mm010=Ge(t,[-.5,i.dims[2]-.5,-.5],a),t.mm001=Ge(t,[-.5,-.5,i.dims[3]-.5],a);const o=J();ba(o,a);for(let g=0;g<3;g++)for(let x=0;x<3;x++)o[g*4+x]=a[g*4+n[x]-1];const l=[0,0,0];o[0]<0&&(l[0]=1),o[5]<0&&(l[1]=1),o[10]<0&&(l[2]=1),t.dimsRAS=[i.dims[0],i.dims[n[0]],i.dims[n[1]],i.dims[n[2]]],t.pixDimsRAS=[i.pixDims[0],i.pixDims[n[0]],i.pixDims[n[1]],i.pixDims[n[2]]],t.permRAS=n.slice();for(let g=0;g<3;g++)l[g]===1&&(t.permRAS[g]=-t.permRAS[g]);if(ar(n,[1,2,3])&&ar(l,[0,0,0])){t.toRAS=J(),t.matRAS=de(a),or(t),t.img2RASstep=[1,t.dimsRAS[1],t.dimsRAS[1]*t.dimsRAS[2]],t.img2RASstart=[0,0,0];return}qs(a),a[0]=1-l[0]*2,a[5]=1-l[1]*2,a[10]=1-l[2]*2,a[3]=(i.dims[n[0]]-1)*l[0],a[7]=(i.dims[n[1]]-1)*l[1],a[11]=(i.dims[n[2]]-1)*l[2];const c=J();Se(c,a),Ye(c,c,o),t.matRAS=de(c),a=Ee(0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1),a[n[0]-1+0]=-l[0]*2+1,a[n[1]-1+4]=-l[1]*2+1,a[n[2]-1+8]=-l[2]*2+1,a[3]=l[0],a[7]=l[1],a[11]=l[2],t.toRAS=de(a),a[3]=0,a[7]=0,a[11]=0,a[12]=0,(t.permRAS[0]===-1||t.permRAS[1]===-1||t.permRAS[2]===-1)&&(a[12]=i.dims[1]-1),a[13]=0,(t.permRAS[0]===-2||t.permRAS[1]===-2||t.permRAS[2]===-2)&&(a[13]=i.dims[2]-1),a[14]=0,(t.permRAS[0]===-3||t.permRAS[1]===-3||t.permRAS[2]===-3)&&(a[14]=i.dims[3]-1),t.toRASvox=de(a),F.debug(t.hdr.dims),F.debug(t.dimsRAS);const h=t.hdr;n=t.permRAS;const d=[Math.abs(n[0]),Math.abs(n[1]),Math.abs(n[2])],f=[h.dims[d[0]],h.dims[d[1]],h.dims[d[2]]],u=[1,h.dims[1],h.dims[1]*h.dims[2]],m=[u[d[0]-1],u[d[1]-1],u[d[2]-1]],p=[0,0,0];for(let g=0;g<3;g++)n[g]<0&&(p[g]=m[g]*(f[g]-1),m[g]=-m[g]);t.img2RASstep=m,t.img2RASstart=p,or(t)}async function Fh(t,e=1){if(!t.permRAS)throw new Error("permRAS undefined");if(!t.hdr)throw new Error("hdr undefined");const i=ui({...t.hdr,vox_offset:352},!1),r=await Nt(i.buffer,!0);e===1?(r.dims[0]=3,r.dims[4]=1):e>1&&(r.dims[0]=4,r.dims[4]=e);const s=t.permRAS.slice();if(s[0]===1&&s[1]===2&&s[2]===3)return r;r.qform_code=0;for(let a=1;a<4;a++)r.dims[a]=t.dimsRAS[a];for(let a=0;a<t.pixDimsRAS.length;a++)r.pixDims[a]=t.pixDimsRAS[a];let n=0;for(let a=0;a<4;a++)for(let o=0;o<4;o++)r.affine[a][o]=t.matRAS[n],n++;return r}function Bh(t,e=0){if(!t.permRAS)throw new Error("permRAS undefined");if(!t.img)throw new Error("img undefined");if(!t.hdr)throw new Error("hdr undefined");const i=t.permRAS.slice();if(i[0]===1&&i[1]===2&&i[2]===3)return t.img;const r=t.hdr,s=r.dims[1]*r.dims[2]*r.dims[3];let n=e*s;(n+s>t.img.length||n<0)&&(n=0,F.warn(`img2RAS nVolume (${e}) out of bounds (${e}+1)×${s} > ${t.img.length}`));const a=t.img.slice(0,s),o=[Math.abs(i[0]),Math.abs(i[1]),Math.abs(i[2])],l=[r.dims[o[0]],r.dims[o[1]],r.dims[o[2]]],c=[1,r.dims[1],r.dims[1]*r.dims[2]],h=[c[o[0]-1],c[o[1]-1],c[o[2]-1]],d=[0,0,0];for(let u=0;u<3;u++)i[u]<0&&(d[u]=h[u]*(l[u]-1),h[u]=-h[u]);let f=0;for(let u=0;u<l[2];u++){const m=d[2]+u*h[2];for(let p=0;p<l[1];p++){const g=d[1]+p*h[1];for(let x=0;x<l[0];x++){const A=d[0]+x*h[0];a[f]=t.img[A+g+m+n],f++}}}return a}function Vn(t,e){e.length!==t.nVox3D*3&&F.warn("float32V1asRGBA() expects "+t.nVox3D*3+"voxels, got ",+e.length);const i=e.slice();t.hdr.datatypeCode=2304,t.nFrame4D=1;for(let l=4;l<7;l++)t.hdr.dims[l]=1;t.hdr.dims[0]=3;const r=new Uint8Array(t.nVox3D*4);let s=1;for(let l=0;l<t.nVox3D*3;l++)isNaN(i[l])||(s=Math.max(s,Math.abs(i[l])));const n=255/s,a=t.nVox3D*2;let o=0;for(let l=0;l<t.nVox3D;l++){const c=i[l],h=i[l+t.nVox3D],d=i[l+a];r[o]=Math.abs(c*n),r[o+1]=Math.abs(h*n),r[o+2]=Math.abs(d*n);const f=+(c>0)*1,u=+(h>0)*2,m=+(d>0)*4;let p=248+f+u+m;Math.abs(c)+Math.abs(h)+Math.abs(d)<.1&&(p=0),r[o+3]=p,o+=4}return r}function Uh(t,e=!1,i=!1,r=!1){let s=t.v1;if(!s&&t.nFrame4D===3&&t.img.constructor===Float32Array&&(s=t.img.slice()),!s)return F.warn("Image does not have V1 data"),!1;if(e)for(let n=0;n<t.nVox3D;n++)s[n]=-s[n];if(i)for(let n=t.nVox3D;n<2*t.nVox3D;n++)s[n]=-s[n];if(r)for(let n=2*t.nVox3D;n<3*t.nVox3D;n++)s[n]=-s[n];return t.img=Vn(t,s),!0}function Tt(t,e){if(!t.hdr)throw new Error("hdr undefined");return t.hdr.scl_slope===0&&(t.hdr.scl_slope=1),e*t.hdr.scl_slope+t.hdr.scl_inter}function Rh(t,e){if(!t.hdr)throw new Error("hdr undefined");return t.hdr.scl_slope===0&&(t.hdr.scl_slope=1),(e-t.hdr.scl_inter)/t.hdr.scl_slope}function Fr(t,e=Number.POSITIVE_INFINITY,i=!0){if(!t.hdr)throw new Error("hdr undefined");if(!t.img)throw new Error("img undefined");let r=Number.POSITIVE_INFINITY,s=Number.NEGATIVE_INFINITY,n=0,a=0,o=t.hdr.dims[1]*t.hdr.dims[2]*t.hdr.dims[3];const l=Math.floor(t.img.length/o);e>=l&&(e=t.frame4D),e=Math.min(e,l-1);const c=e*o;let h=[];if(i){const U=[Math.floor(.25*t.hdr.dims[1]),Math.floor(.25*t.hdr.dims[2]),Math.floor(.25*t.hdr.dims[3])],B=[t.hdr.dims[1]-2*U[0],t.hdr.dims[2]-2*U[1],t.hdr.dims[3]-2*U[2]],V=[B[0]+U[0],B[1]+U[1],B[2]+U[2]];o=B[0]*B[1]*B[2],h=new t.img.constructor(o);let R=-1,P=0;for(let L=0;L<t.hdr.dims[3];L++)for(let N=0;N<t.hdr.dims[2];N++)for(let Y=0;Y<t.hdr.dims[1];Y++)R++,!(Y<U[0]||N<U[1]||L<U[2])&&(Y>=V[0]||N>=V[1]||L>=V[2]||(h[P]=t.img[R+c],P++))}else{h=new t.img.constructor(o);for(let S=0;S<o;S++)h[S]=t.img[S+c]}const d=h.constructor!==Float64Array&&h.constructor!==Float32Array&&t.ignoreZeroVoxels;if(d)for(let S=0;S<o;S++)r=Math.min(h[S],r),s=Math.max(h[S],s),h[S]===0&&n++;else for(let S=0;S<o;S++){if(isNaN(h[S])){a++;continue}h[S]===0&&(n++,t.ignoreZeroVoxels)||(r=Math.min(h[S],r),s=Math.max(h[S],s))}t.ignoreZeroVoxels&&r===s&&n>0&&(r=0);const f=Tt(t,r),u=Tt(t,s),m=re.colormapFromKey(t._colormap);let p=0,g=0;if(m.min!==void 0&&(p=m.min),m.max!==void 0&&(g=m.max),p===g&&t.trustCalMinMax&&isFinite(t.hdr.cal_min)&&isFinite(t.hdr.cal_max)&&t.hdr.cal_max>t.hdr.cal_min)return t.cal_min=t.hdr.cal_min,t.cal_max=t.hdr.cal_max,t.robust_min=t.cal_min,t.robust_max=t.cal_max,t.global_min=f,t.global_max=u,[t.hdr.cal_min,t.hdr.cal_max,t.hdr.cal_min,t.hdr.cal_max];if(p!==g)return t.cal_min=p,t.cal_max=g,t.robust_min=t.cal_min,t.robust_max=t.cal_max,[p,g,p,g];const x=100*n/(o-0);let A=!1;x>60&&!t.ignoreZeroVoxels&&(F.warn(`${Math.round(x)}% of voxels are zero: ignoring zeros for cal_max`),A=!0,t.ignoreZeroVoxels=!0),t.ignoreZeroVoxels||(n=0),n+=a;const y=Math.round((o-0-n)*t.percentileFrac);if(y<1||r===s)return i?Fr(t,e,!1):(F.debug("no variability in image intensity?"),t.cal_min=f,t.cal_max=u,t.robust_min=t.cal_min,t.robust_max=t.cal_max,t.global_min=f,t.global_max=u,[f,u,f,u]);const v=1001,b=(v-1)/(s-r),w=new Array(v);for(let S=0;S<v;S++)w[S]=0;if(d)for(let S=0;S<o;S++)w[Math.round((h[S]-r)*b)]++;else if(t.ignoreZeroVoxels)for(let S=0;S<o;S++)h[S]!==0&&(isNaN(h[S])||w[Math.round((h[S]-r)*b)]++);else for(let S=0;S<o;S++)isNaN(h[S])||w[Math.round((h[S]-r)*b)]++;let C=0,M=0;for(;C<y;)C+=w[M],M++;M--,C=0;let T=v;for(;C<y;)T--,C+=w[T];if(M===T){let S=-1;for(;S!==0;)M>0&&(M--,w[M]>0&&(S=0)),S!==0&&T<v-1&&(T++,w[T]>0&&(S=0)),M===0&&T===v-1&&(S=0)}let E=Tt(t,M/b+r),I=Tt(t,T/b+r);return t.hdr.cal_min<t.hdr.cal_max&&t.hdr.cal_min>=f&&t.hdr.cal_max<=u&&(E=t.hdr.cal_min,I=t.hdr.cal_max),A&&(E=Math.min(E,0)),t.cal_min=E,t.cal_max=I,t.hdr.intent_code===1002&&(t.cal_min=f,t.cal_max=u),t.robust_min=t.cal_min,t.robust_max=t.cal_max,t.global_min=f,t.global_max=u,[E,I,f,u]}function Fi(t,e){t._colormap=e,Fr(t),t.onColormapChange&&t.onColormapChange(t)}function Vh(t,e){t.colormapLabel=re.makeLabelLut(e)}async function Ph(t,e){t.colormapLabel=await re.makeLabelLutFromUrl(e)}function gs(t){return t._colormap}function Nh(t){return t._opacity}function Lh(t,e){t._opacity=e,t.onOpacityChange&&t.onOpacityChange(t)}async function 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ai(r.body,s);const a=new DataView(n.buffer,n.byteOffset,n.byteLength),o=a.getUint16(0,!0),l=o===348;if(!l&&!(o===23553)||(n.length>111&&(s=a.getFloat32(108,l)),s>n.length&&(n=await ai(r.body,s)),!(n[0]===92&&n[1]===1||n[1]===92&&n[0]===1)))return null;const d=await Nt(n.buffer);if(!d)throw new Error("Could not read NIfTI header");const f=d.numBitsPerVoxel/8,u=[1,2,3].reduce((y,v)=>y*(d.dims[v]>1?d.dims[v]:1),1),m=[4,5,6].reduce((y,v)=>y*(d.dims[v]>1?d.dims[v]:1),1),p=Math.max(Math.min(i,m),1),g=d.vox_offset+p*u*f;if(p===m)return null;const x=await fetch(t,{headers:e,cache:"force-cache"});return(await ai(x.body,g)).buffer.slice(0,g)}async function zh(t="",e={},i=NaN){if(isNaN(i))return null;const s=(await fetch(t,{headers:e,cache:"force-cache"})).body.getReader(),{value:n,done:a}=await s.read();let o=n;if(a||!o||o.length<2)throw new Error("Not enough data to determine compression");const l=new DataView(o.buffer,o.byteOffset,o.byteLength),c=l.getUint16(0,!0);if(c===35615)return await s.cancel(),Pn(t,e,i);const d=c===348;if(!d&&!(c===23553))return await s.cancel(),null;let u=352;for(o.length>111&&(u=l.getFloat32(108,d));o.length<u;){let C=function(E,I){const S=new Uint8Array(E.length+I.length);return S.set(E,0),S.set(I,E.length),S};const{value:M,done:T}=await s.read();if(T||!M)break;o=C(o,M)}const m=await Nt(o.buffer);if(!m)throw new Error("Could not read NIfTI header");const p=m.numBitsPerVoxel/8,g=[1,2,3].reduce((C,M)=>C*(m.dims[M]>1?m.dims[M]:1),1),x=[4,5,6].reduce((C,M)=>C*(m.dims[M]>1?m.dims[M]:1),1),A=Math.max(Math.min(i,x),1),y=m.vox_offset+A*g*p,v=new Uint8Array(y),b=Math.min(o.length,y);v.set(o.subarray(0,b),0);let w=b;for(;w<y;){const{value:C,done:M}=await s.read();if(M||!C)return await s.cancel(),null;const T=Math.min(C.length,y-w);v.set(C.subarray(0,T),w),w+=T}return await s.cancel(),v.buffer}async function Gh(t,e=NaN){let i=t.stream();if(!isNaN(e)){let h=0;const d=new TransformStream({transform(f,u){if(h>=e){u.terminate();return}const 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async create(e,i,r){const s=new Nn(e);s.chunkClient=new l0({baseUrl:i}),s.pyramidInfo=await s.chunkClient.fetchInfo(),s.chunkCache=new Kt(r.cacheSize??500);const n=r.maxTextureSize??2048,a=r.maxVolumeSize??256,l=s.pyramidInfo.levels[0].shape;l.every(f=>f<=a&&f<=n)?s.pyramidInfo.is3D&&l.length>=3?s.volumeDims={depth:l[0],height:l[1],width:l[2]}:s.volumeDims={height:l[0],width:l[1],depth:1}:s.volumeDims={width:Math.min(a,n),height:Math.min(a,n),depth:Math.min(a,n)},s.datatypeCode=c0(s.pyramidInfo.levels[0].dtype),s.convertUnitsToMm=r.convertUnitsToMm??!0,s.channel=r.channel??0;const h=s.pyramidInfo.axisMapping;for(const f of h.nonSpatialAxes)f.name==="c"&&(s.nonSpatialCoords[f.name]=s.channel);const d=Math.max(0,Math.min(r.level,s.pyramidInfo.levels.length-1));return s.pyramidLevel=d,s.updateLevelInfo(),s.centerX=s.levelDims.width/2,s.centerY=s.levelDims.height/2,s.centerZ=s.levelDims.depth/2,s.configureHostImage(),s}async loadInitialChunks(){await this.updateVolume()}updateLevelInfo(){const e=this.pyramidInfo.levels[this.pyramidLevel],i=e.shape;this.pyramidInfo.is3D&&i.length>=3?this.levelDims={depth:i[0],height:i[1],width:i[2]}:this.levelDims={height:i[0],width:i[1],depth:1};const r=e.chunks;this.pyramidInfo.is3D&&r.length>=3?this.chunkSize={depth:r[0],height:r[1],width:r[2]}:this.chunkSize={height:r[0],width:r[1],depth:1},e.scales?this.pyramidInfo.is3D&&e.scales.length>=3?this.voxelScales={depth:e.scales[0],height:e.scales[1],width:e.scales[2]}:e.scales.length>=2&&(this.voxelScales={height:e.scales[0],width:e.scales[1],depth:1}):this.voxelScales={width:1,height:1,depth:1},e.translations?(this.pyramidInfo.is3D&&e.translations.length>=3?this.voxelTranslations={depth:e.translations[0],height:e.translations[1],width:e.translations[2]}:e.translations.length>=2&&(this.voxelTranslations={height:e.translations[0],width:e.translations[1],depth:0}),this.hasTranslations=!0):(this.voxelTranslations={width:0,height:0,depth:0},this.hasTranslations=!1)}configureHostImage(){const{width:e,height:i,depth:r}=this.volumeDims,s=h0(this.datatypeCode),{scaleW:n,scaleH:a,scaleD:o}=this.getConvertedScales(),l=new G;l.littleEndian=!0,l.dims=[3,e,i,r,1,0,0,0],l.pixDims=[1,n,a,o,1,0,0,0],l.datatypeCode=this.datatypeCode,l.numBitsPerVoxel=s*8,l.scl_inter=0,l.scl_slope=1,l.sform_code=2,l.magic="n+1",l.vox_offset=352,l.affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]];const c=this.hostImage;c.name=`zarr:${this.pyramidInfo.name}`,c.id=di(),c._colormap="gray",c._opacity=1,c.hdr=l,c.nFrame4D=1,c.frame4D=0,c.nTotalFrame4D=1,c.nVox3D=e*i*r,c.dims=[e,i,r],c.pixDims=[n,a,o],c.img=d0(this.datatypeCode,e*i*r),this.updateAffine(),c.originalAffine=pt(l.affine),c.cal_min=0,c.cal_max=0,c.robust_min=0,c.robust_max=0,c.global_min=0,c.global_max=0}getConvertedScales(){const e=this.pyramidInfo.spatialUnits;let i=this.voxelScales.depth,r=this.voxelScales.height,s=this.voxelScales.width;return this.convertUnitsToMm&&e&&(e.length>=3?(i=Pe(i,e[0]),r=Pe(r,e[1]),s=Pe(s,e[2])):e.length>=2&&(r=Pe(r,e[0]),s=Pe(s,e[1]))),{scaleW:s,scaleH:r,scaleD:i}}getConvertedTranslations(){const e=this.pyramidInfo.spatialUnits;let i=this.voxelTranslations.depth,r=this.voxelTranslations.height,s=this.voxelTranslations.width;return this.convertUnitsToMm&&e&&(e.length>=3?(i=Pe(i,e[0]),r=Pe(r,e[1]),s=Pe(s,e[2])):e.length>=2&&(r=Pe(r,e[0]),s=Pe(s,e[1]))),{transW:s,transH:r,transD:i}}updateAffine(){const e=this.hostImage.hdr;if(!e)return;const{width:i,height:r,depth:s}=this.volumeDims,n=this.pyramidInfo.axisMapping.spatialAxisNames;if(this.hasTranslations&&n.length>=3){const{scaleW:a,scaleH:o,scaleD:l}=this.getConvertedScales(),{transW:c,transH:h,transD:d}=this.getConvertedTranslations(),f=this.centerX-i/2,u=this.centerY-r/2,m=this.centerZ-s/2,p=[{name:n[n.length-1],scale:a,trans:c+f*a},{name:n[n.length-2],scale:o,trans:h+u*o},{name:n[n.length-3],scale:l,trans:d+m*l}],g=[[0,0,0,0],[0,0,0,0],[0,0,0,0],[0,0,0,1]];for(let x=0;x<3;x++){const A=p[x].name==="x"?0:p[x].name==="y"?1:2;g[A][x]=p[x].scale,g[A][3]=p[x].trans}g[0][3]+=this.worldOffsetMM[0],g[1][3]+=this.worldOffsetMM[1],g[2][3]+=this.worldOffsetMM[2],e.affine=g}else{const{scaleW:a,scaleH:o,scaleD:l}=this.getConvertedScales(),c=this.centerX-i/2,h=this.centerY-r/2,d=this.centerZ-s/2;if(n.length>=2){const f=[{name:n[n.length-1],scale:a,trans:c*a},{name:n[n.length-2],scale:o,trans:h*o},{name:"z",scale:l,trans:d*l}],u=[[0,0,0,0],[0,0,0,0],[0,0,0,0],[0,0,0,1]];for(let m=0;m<3;m++){const p=f[m].name==="x"?0:f[m].name==="y"?1:2;u[p][m]=f[m].scale,u[p][3]=f[m].trans}u[0][3]+=this.worldOffsetMM[0],u[1][3]+=this.worldOffsetMM[1],u[2][3]+=this.worldOffsetMM[2],e.affine=u}else e.affine=[[a,0,0,c*a+this.worldOffsetMM[0]],[0,-o,0,h*o+this.worldOffsetMM[1]],[0,0,-l,d*l+this.worldOffsetMM[2]],[0,0,0,1]]}this.hostImage.calculateRAS(),this.hostImage.originalAffine=pt(this.hostImage.hdr.affine)}beginDrag(){this.centerAtDragStart={x:this.centerX,y:this.centerY,z:this.centerZ}}endDrag(){this.centerAtDragStart=null}async panBy(e,i,r=0){this.centerX-=e,this.centerY-=i,this.centerZ-=r,this.clampCenter(),this.updateAffine(),await this.updateVolume()}async panTo(e,i,r){const s=this.centerX,n=this.centerY,a=this.centerZ;this.centerX=e,this.centerY=i,r!==void 0&&(this.centerZ=r),this.clampCenter(),!(Math.abs(this.centerX-s)<.001&&Math.abs(this.centerY-n)<.001&&Math.abs(this.centerZ-a)<.001)&&(this.updateAffine(),await this.updateVolume())}async setPyramidLevel(e){const i=Math.max(0,Math.min(this.pyramidInfo.levels.length-1,e));if(i===this.pyramidLevel)return;const r=this.levelDims;this.pyramidLevel=i,this.updateLevelInfo();const s=this.levelDims;this.centerX=this.centerX/r.width*s.width,this.centerY=this.centerY/r.height*s.height,this.centerZ=this.centerZ/r.depth*s.depth,this.clampCenter(),this.updateAffine(),await this.updateVolume()}getViewportState(){return{centerX:this.centerX,centerY:this.centerY,centerZ:this.centerZ,level:this.pyramidLevel}}getPyramidInfo(){return this.pyramidInfo}getPyramidLevel(){return this.pyramidLevel}getLevelDims(){return{...this.levelDims}}getVolumeDims(){return{...this.volumeDims}}getWorldOffset(){return[...this.worldOffsetMM]}setWorldCenter(e){const{scaleW:i,scaleH:r,scaleD:s}=this.getConvertedScales(),{transW:n,transH:a,transD:o}=this.getConvertedTranslations(),l=this.pyramidInfo.axisMapping.spatialAxisNames,c=this.levelDims.width/2*i+n,h=this.levelDims.height/2*r+a,d=this.levelDims.depth/2*s+o,f=[0,0,0],u=[{name:l[l.length-1],phys:c},{name:l[l.length-2],phys:h},{name:l.length>=3?l[l.length-3]:"z",phys:d}];for(const m of u){const p=m.name==="x"?0:m.name==="y"?1:2;f[p]=m.phys}this.worldOffsetMM=[e[0]-f[0],e[1]-f[1],e[2]-f[2]],this.centerX=this.levelDims.width/2,this.centerY=this.levelDims.height/2,this.centerZ=this.levelDims.depth/2,this.clampCenter(),this.updateAffine()}mmToLevelCoords(e,i,r){e-=this.worldOffsetMM[0],i-=this.worldOffsetMM[1],r-=this.worldOffsetMM[2];const{scaleW:s,scaleH:n,scaleD:a}=this.getConvertedScales(),o=this.pyramidInfo.axisMapping.spatialAxisNames,l={x:e,y:i,z:r};let c=0,h=0,d=0;if(o.length>=2){const f=o[o.length-1],u=o[o.length-2],m=o.length>=3?o[o.length-3]:"z",p=l[f]??e,g=l[u]??i,x=l[m]??r;if(this.hasTranslations){const{transW:A,transH:y,transD:v}=this.getConvertedTranslations();c=s!==0?(p-A)/s:0,h=n!==0?(g-y)/n:0,d=a!==0?(x-v)/a:0}else c=s!==0?p/s:0,h=n!==0?g/n:0,d=a!==0?x/a:0}else if(this.hasTranslations){const{transW:f,transH:u,transD:m}=this.getConvertedTranslations();c=s!==0?(e-f)/s:0,h=n!==0?(i-u)/n:0,d=a!==0?(r-m)/a:0}else c=s!==0?e/s:0,h=n!==0?i/n:0,d=a!==0?r/a:0;return{width:Math.round(c),height:Math.round(h),depth:Math.round(d),level:this.pyramidLevel,levelDims:{...this.levelDims}}}clampCenter(){const e=this.volumeDims.width/2,i=this.volumeDims.height/2,r=this.volumeDims.depth/2;this.centerX=Math.max(-e,Math.min(this.levelDims.width+e,this.centerX)),this.centerY=Math.max(-i,Math.min(this.levelDims.height+i,this.centerY)),this.centerZ=Math.max(-r,Math.min(this.levelDims.depth+r,this.centerZ))}getVisibleChunks(){const{width:i,height:r,depth:s}=this.volumeDims,n=this.pyramidLevel,a=Math.max(0,Math.floor(this.centerX-i/2)),o=Math.min(this.levelDims.width,Math.ceil(this.centerX+i/2)),l=Math.max(0,Math.floor(this.centerY-r/2)),c=Math.min(this.levelDims.height,Math.ceil(this.centerY+r/2)),h=Math.max(0,Math.floor(this.centerZ-s/2)),d=Math.min(this.levelDims.depth,Math.ceil(this.centerZ+s/2)),f=Math.max(0,Math.floor(a/this.chunkSize.width)),u=Math.max(0,Math.floor(l/this.chunkSize.height)),m=Math.max(0,Math.floor(h/this.chunkSize.depth)),p=Math.min(Math.ceil(this.levelDims.width/this.chunkSize.width),Math.ceil(o/this.chunkSize.width)),g=Math.min(Math.ceil(this.levelDims.height/this.chunkSize.height),Math.ceil(c/this.chunkSize.height)),x=Math.min(Math.ceil(this.levelDims.depth/this.chunkSize.depth),Math.ceil(d/this.chunkSize.depth)),A=[];for(let w=m;w<x;w++){for(let C=u;C<g;C++){for(let M=f;M<p&&(this.pyramidInfo.is3D?A.push({level:n,x:M,y:C,z:w}):A.push({level:n,x:M,y:C}),!(A.length>=1e3));M++);if(A.length>=1e3)break}if(A.length>=1e3)break}const y=(f+p)/2,v=(u+g)/2,b=(m+x)/2;return A.sort((w,C)=>{const M=(w.x-y)**2+(w.y-v)**2+((w.z??0)-b)**2,T=(C.x-y)**2+(C.y-v)**2+((C.z??0)-b)**2;return M-T}),A}async updateVolume(){if(this.isUpdating){this.needsUpdate=!0,this.currentAbortController?.abort();return}this.isUpdating=!0;try{do{this.needsUpdate=!1,this.currentAbortController?.abort();const e=new AbortController;this.currentAbortController=e,await new Promise(i=>{requestAnimationFrame(()=>i())}),!this.needsUpdate&&(this.clearVolumeData(),await this.assembleVisibleChunks(e.signal))}while(this.needsUpdate)}finally{this.isUpdating=!1}}clearVolumeData(){const e=this.hostImage.img;if(e.fill)e.fill(0);else for(let i=0;i<e.length;i++)e[i]=0;this.pendingChunkCount=0,this.lastRenderedChunkCount=0,this.updateDebounceTimer!==null&&(clearTimeout(this.updateDebounceTimer),this.updateDebounceTimer=null)}async assembleVisibleChunks(e){const i=this.getVisibleChunks(),r=this.pyramidInfo.name,s=this.pyramidLevel,n=[],a=[];for(const o of i){const l=Kt.getKey(r,o.level,o.x,o.y,o.z);this.chunkCache.has(l)?n.push(o):this.chunkCache.isLoading(l)||a.push(o)}for(const o of n){const l=Kt.getKey(r,o.level,o.x,o.y,o.z),c=this.chunkCache.get(l);c&&(this.assembleChunkIntoVolume(o,c),this.pendingChunkCount++)}if(n.length>0&&(this.updateCalibration(),this.onChunksUpdated?.()),a.length>0){const o=a.map(async l=>{const c=Kt.getKey(r,l.level,l.x,l.y,l.z);this.chunkCache.startLoading(c);try{const h=await this.chunkClient.fetchChunk(l.level,l.x,l.y,l.z,this.nonSpatialCoords,e);if(this.chunkCache.doneLoading(c),e?.aborted)return;h&&(this.chunkCache.set(c,h),this.pyramidLevel===s&&(this.assembleChunkIntoVolume(l,h),this.pendingChunkCount++,this.scheduleChunksUpdated()))}catch(h){if(this.chunkCache.doneLoading(c),h instanceof DOMException&&h.name==="AbortError")return;console.warn(`Failed to fetch chunk ${c}:`,h)}});await Promise.all(o),this.updateDebounceTimer!==null&&(clearTimeout(this.updateDebounceTimer),this.updateDebounceTimer=null),this.pendingChunkCount>this.lastRenderedChunkCount&&(this.lastRenderedChunkCount=this.pendingChunkCount,this.updateCalibration(),this.onChunksUpdated?.()),this.onAllChunksLoaded?.()}}assembleChunkIntoVolume(e,i){const{width:r,height:s,depth:n}=this.volumeDims,a=this.hostImage.img,o=e.x*this.chunkSize.width,l=e.y*this.chunkSize.height,c=(e.z??0)*this.chunkSize.depth,h=this.centerX-r/2,d=this.centerY-s/2,f=this.centerZ-n/2,u=Math.round(o-h),m=Math.round(l-d),p=Math.round(c-f),g=Math.min(this.chunkSize.width,this.levelDims.width-o),x=Math.min(this.chunkSize.height,this.levelDims.height-l),A=Math.min(this.chunkSize.depth,this.levelDims.depth-c);if(g<=0||x<=0||A<=0)return;if(!this.calibrationDone){const w=Math.max(1,Math.floor(i.length/2e3));for(let C=0;C<i.length;C+=w){const M=i[C];M<this.runningMin&&(this.runningMin=M),M>this.runningMax&&(this.runningMax=M)}}const y=this.chunkSize.width*this.chunkSize.height*this.chunkSize.depth,v=i.length>=y?this.chunkSize.width:g,b=i.length>=y?this.chunkSize.height:x;for(let w=0;w<A;w++){const C=p+w;if(!(C<0||C>=n))for(let M=0;M<x;M++){const T=m+M;if(!(T<0||T>=s))for(let E=0;E<g;E++){const I=u+E;if(I<0||I>=r)continue;const S=w*b*v+M*v+E,U=I+T*r+C*r*s;S>=0&&S<i.length&&U>=0&&U<a.length&&(a[U]=i[S])}}}}updateCalibration(){this.calibrationDone||this.runningMin<1/0&&this.runningMax>-1/0&&(this.hostImage.cal_min=this.runningMin,this.hostImage.cal_max=this.runningMax,this.hostImage.robust_min=this.runningMin,this.hostImage.robust_max=this.runningMax,this.hostImage.global_min=this.runningMin,this.hostImage.global_max=this.runningMax,this.calibrationDone=!0)}scheduleChunksUpdated(){this.pendingChunkCount!==this.lastRenderedChunkCount&&(this.updateDebounceTimer!==null&&clearTimeout(this.updateDebounceTimer),this.updateDebounceTimer=setTimeout(()=>{this.updateDebounceTimer=null,this.lastRenderedChunkCount=this.pendingChunkCount,this.updateCalibration(),this.onChunksUpdated?.()},this.UPDATE_DEBOUNCE_MS))}clearCache(){this.chunkCache.clear()}async refresh(){await this.updateVolume()}},Me=class ht{constructor(e=null,i="",r="gray",s=1,n=null,a=NaN,o=NaN,l=!0,c=.02,h=!1,d=!1,f="",u=0,m=j.UNKNOWN,p=NaN,g=NaN,x=!0,A=null,y=0){D(this,"name"),D(this,"id"),D(this,"url"),D(this,"headers"),D(this,"_colormap"),D(this,"_opacity"),D(this,"percentileFrac"),D(this,"ignoreZeroVoxels"),D(this,"trustCalMinMax"),D(this,"colormapNegative"),D(this,"colormapLabel"),D(this,"colormapInvert"),D(this,"nFrame4D"),D(this,"frame4D"),D(this,"nTotalFrame4D"),D(this,"cal_minNeg"),D(this,"cal_maxNeg"),D(this,"colorbarVisible",!0),D(this,"modulationImage",null),D(this,"modulateAlpha",0),D(this,"series",[]),D(this,"nVox3D"),D(this,"oblique_angle"),D(this,"maxShearDeg"),D(this,"useQFormNotSForm"),D(this,"colormapType"),D(this,"pixDims"),D(this,"matRAS"),D(this,"pixDimsRAS"),D(this,"obliqueRAS"),D(this,"dimsRAS"),D(this,"permRAS"),D(this,"img2RASstep"),D(this,"img2RASstart"),D(this,"toRAS"),D(this,"toRASvox"),D(this,"frac2mm"),D(this,"frac2mmOrtho"),D(this,"extentsMinOrtho"),D(this,"extentsMaxOrtho"),D(this,"mm2ortho"),D(this,"hdr",null),D(this,"extensions"),D(this,"imageType"),D(this,"img"),D(this,"imaginary"),D(this,"v1"),D(this,"fileObject"),D(this,"dims"),D(this,"onColormapChange",()=>{}),D(this,"onOpacityChange",()=>{}),D(this,"zarrHelper",null),D(this,"_hasExplicitZarrCenter",!1),D(this,"mm000"),D(this,"mm100"),D(this,"mm010"),D(this,"mm001"),D(this,"cal_min"),D(this,"cal_max"),D(this,"robust_min"),D(this,"robust_max"),D(this,"global_min"),D(this,"global_max"),D(this,"urlImgData"),D(this,"isManifest"),D(this,"limitFrames4D"),D(this,"originalAffine"),this.init(e,i,r,s,n,a,o,l,c,h,d,f,u,m,p,g,x,A,y)}init(e=null,i="",r="",s=1,n=null,a=NaN,o=NaN,l=!0,c=.02,h=!1,d=!1,f="",u=0,m=j.UNKNOWN,p=NaN,g=NaN,x=!0,A=null,y=0,v=null){const b=r==="";if(b&&(r="gray"),this.name=i,this.imageType=m,this.id=di(),this._colormap=r,this._opacity=s>1?1:s,this.percentileFrac=c,this.ignoreZeroVoxels=h,this.trustCalMinMax=l,this.colormapNegative=f,this.colormapLabel=A,this.frame4D=u,this.cal_minNeg=p,this.cal_maxNeg=g,this.colorbarVisible=x,this.colormapType=y,this.useQFormNotSForm=d,!e)return;if(b&&this.hdr&&this.hdr.intent_code===1002&&(r="random",this._colormap=r),this.hdr&&typeof this.hdr.magic=="number"&&(this.hdr.magic="n+1"),this.nFrame4D=1,this.hdr)for(let T=4;T<7;T++)this.hdr.dims[T]>1&&(this.nFrame4D*=this.hdr.dims[T]);if(this.frame4D=Math.min(this.frame4D,this.nFrame4D-1),this.nTotalFrame4D=this.nFrame4D,!this.hdr||!v)return;this.hdr.dims[1]===0&&this.hdr.dims[2]===0&&this.hdr.dims[3]===0&&F.warn("Invalid volume: First three dimensions are all zero"),this.hdr.dims[1]=Math.max(this.hdr.dims[1],1),this.hdr.dims[2]=Math.max(this.hdr.dims[2],1),this.hdr.dims[3]=Math.max(this.hdr.dims[3],1),this.nVox3D=this.hdr.dims[1]*this.hdr.dims[2]*this.hdr.dims[3];const w=this.nVox3D*(this.hdr.numBitsPerVoxel/8),C=v.byteLength/w;C!==this.nFrame4D&&(C>0&&C*w===v.byteLength?F.debug("Loading the first "+C+" of "+this.nFrame4D+" volumes"):F.warn("This header does not match voxel data",this.hdr,v.byteLength),this.nFrame4D=C),(this.hdr.intent_code===1007||this.hdr.intent_code===2003)&&this.nFrame4D===3&&this.hdr.datatypeCode===16&&(v=this.float32V1asRGBA(new Float32Array(v)).buffer),Jh(this.hdr,d),Hh(v,this.hdr);const M=qh(v,this.hdr);this.img=M.img,M.imaginary&&(this.imaginary=M.imaginary),M.updatedDatatypeCode!==void 0&&(this.hdr.datatypeCode=M.updatedDatatypeCode),M.updatedNumBitsPerVoxel!==void 0&&(this.hdr.numBitsPerVoxel=M.updatedNumBitsPerVoxel),this.calculateRAS(),this.originalAffine=pt(this.hdr.affine),isNaN(a)||(this.hdr.cal_min=a),isNaN(o)||(this.hdr.cal_max=o),this.calMinMax()}static async new(e=null,i="",r="",s=1,n=null,a=NaN,o=NaN,l=!0,c=.02,h=!1,d=!1,f="",u=0,m=j.UNKNOWN,p=NaN,g=NaN,x=!0,A=null,y=0,v){const b=new ht,w=/(?:\.([^.]+))?$/;let C=w.exec(i)[1]||"";C=C.toUpperCase(),C==="GZ"&&(C=w.exec(i.slice(0,-3))[1],C=C.toUpperCase());let M=null;if(m===j.UNKNOWN&&(m=j.parse(C)),e instanceof ArrayBuffer&&e.byteLength>=2&&m===j.DCM){const T=new Uint8Array(e);(T[0]===92&&T[1]===1||T[1]===92&&T[0]===1)&&(m=j.NII)}switch(b.imageType=m,m){case j.DCM_FOLDER:case j.DCM_MANIFEST:case j.DCM:return;case j.FIB:[M,b.v1]=await Mt.readFIB(b,e);break;case j.MIH:case j.MIF:M=await sr.readMIF(b,e,n);break;case j.NHDR:case j.NRRD:if(M=await Fn.readNrrd(b,e),M===null)throw new Error(`Failed to parse NHDR/NRRD file ${i}`);break;case j.MHD:case j.MHA:M=await rr.readMHA(b,e,n);break;case j.MGH:case j.MGZ:if(M=await Tn.readMgh(b,e,i),M===null)throw new Error(`Failed to parse MGH/MGZ file ${i}`);break;case j.SRC:M=await Mt.readSRC(b,e);break;case j.V:M=ir.readECAT(b,e);break;case j.V16:M=Ct.readV16(b,e);break;case j.VMR:M=Ct.readVMR(b,e);break;case j.HEAD:M=await tr.readHEAD(b,e,n);break;case j.BMP:M=await ni.readBMP(b,e);break;case j.NPY:M=await Dt.readNPY(b,e);break;case j.NPZ:M=await Dt.readNPZ(b,e);break;case j.ZARR:M=await nr.readZARR(b,e,v);break;case j.NII:if(M=await In.readNifti(b,e,n),M===null)throw new Error(`Failed to parse NIfTI file ${i}.`);break;default:throw new Error("Image type not supported")}return b.init(e,i,r,s,n,a,o,l,c,h,d,f,u,m,p,g,x,A,y,M),b}computeObliqueAngle(e){return Rn(e)}float32V1asRGBA(e){return Vn(this,e)}loadImgV1(e=!1,i=!1,r=!1){return Uh(this,e,i,r)}calculateOblique(){or(this)}readECAT(e){return ir.readECAT(this,e)}readV16(e){return Ct.readV16(this,e)}async readNPY(e){return Dt.readNPY(this,e)}async readNPZ(e){return Dt.readNPZ(this,e)}async imageDataFromArrayBuffer(e){return ni.imageDataFromArrayBuffer(e)}async readBMP(e){return ni.readBMP(this,e)}async readZARR(e,i){return nr.readZARR(this,e,i)}readVMR(e){return Ct.readVMR(this,e)}async readFIB(e){return Mt.readFIB(this,e)}async readSRC(e){return Mt.readSRC(this,e)}async readHEAD(e,i){return tr.readHEAD(this,e,i)}async readMHA(e,i){return rr.readMHA(this,e,i)}async readMIF(e,i){return sr.readMIF(this,e,i)}calculateRAS(){Ih(this)}getAffine(){if(!this.hdr)throw new Error("Image header not loaded");return pt(this.hdr.affine)}setAffine(e){if(!this.hdr)throw new Error("Image header not loaded");this.hdr.affine=pt(e),this.calculateRAS()}applyTransform(e){if(!this.hdr)throw new Error("Image header not loaded");const i=s0(e),r=o0(this.hdr.affine,i);this.hdr.affine=r,this.calculateRAS()}resetAffine(){if(!this.hdr)throw new Error("Image header not loaded");if(!this.originalAffine)throw new Error("Original affine not stored");this.hdr.affine=pt(this.originalAffine),this.calculateRAS()}async hdr2RAS(e=1){return Fh(this,e)}img2RAS(e=0){return Bh(this,e)}vox2mm(e,i){return Ge(this,e,i)}mm2vox(e,i=!1){return Un(this,e,i)}arrayEquals(e,i){return ar(e,i)}setColormap(e){Fi(this,e)}setColormapLabel(e){Vh(this,e)}async setColormapLabelFromUrl(e){return Ph(this,e)}get colormap(){return gs(this)}get colorMap(){return gs(this)}set colormap(e){Fi(this,e)}set colorMap(e){Fi(this,e)}get opacity(){return Nh(this)}set opacity(e){Lh(this,e)}calMinMax(e=Number.POSITIVE_INFINITY,i=!0){return Fr(this,e,i)}intensityRaw2Scaled(e){return Tt(this,e)}intensityScaled2Raw(e){return Rh(this,e)}async saveToUint8Array(e,i=null){return Cn(this,e,i)}async saveToDisk(e="",i=null){return ih(this,e,i)}static async fetchDicomData(e,i={}){return kh(e,i)}static async readFirstDecompressedBytes(e,i){return ai(e,i)}static extractFilenameFromUrl(e){return Oh(e)}static async loadInitialVolumesGz(e="",i={},r=NaN){return Pn(e,i,r)}static async loadInitialVolumes(e="",i={},r=NaN){return zh(e,i,r)}static async loadFromUrl({url:e="",urlImgData:i="",headers:r={},name:s="",colormap:n="",opacity:a=1,cal_min:o=NaN,cal_max:l=NaN,trustCalMinMax:c=!0,percentileFrac:h=.02,ignoreZeroVoxels:d=!1,useQFormNotSForm:f=!1,colormapNegative:u="",frame4D:m=0,isManifest:p=!1,limitFrames4D:g=NaN,imageType:x=j.UNKNOWN,colorbarVisible:A=!0,buffer:y=new ArrayBuffer(0),zarrLevel:v,zarrMaxVolumeSize:b,zarrChannel:w,zarrConvertUnits:C,zarrCenterMM:M}={}){if(e==="")throw Error("url must not be empty");let T=null,E=null,I=null;if(e instanceof Uint8Array&&(e=e.slice().buffer),y.byteLength>0&&(e=y),e instanceof ArrayBuffer)if(E=e,s!=="")e=s;else{const R=new Uint8Array(E);e=R[0]===31&&R[1]===139?"array.nii.gz":"array.nii"}let S="";if(s===""?S=Bi(e):S=Bi(s),x===j.UNKNOWN&&(x=j.parse(S)),x===j.UNKNOWN&&typeof e=="string"){const R=await fetch(e,{});if(R.redirected){const P=this.extractFilenameFromUrl(R.url);P&&P.length>0&&s===""&&(s=P,S=Bi(s),x=j.parse(S))}}if(x===j.ZARR){if(v!==void 0)return await ht.createChunkedZarr(e,{level:v,maxVolumeSize:b,channel:w,convertUnitsToMm:C,colormap:n,opacity:a,zarrCenterMM:M});const R=await $h(e);E=R.dataBuffer,I=R.zarrData}const U=x===j.DCM||j.NII;!E&&U&&(E=await this.loadInitialVolumes(e,r,g)),E||(p?(E=await ht.fetchDicomData(e,r),x=j.DCM_MANIFEST):E=await e0(e,r));const B=t0(e,S.toUpperCase(),i);let V=null;if(B&&(V=await i0(B,r)),!E)throw new Error("Unable to load buffer properly from volume");if(!s){let R;try{R=new URL(e).pathname.split("/")}catch{R=e.split("/")}s=R.slice(-1)[0],s.indexOf("?")>-1&&(s=s.slice(0,s.indexOf("?")))}return T=await this.new(E,s,n,a,V,o,l,c,h,d,f,u,m,x,NaN,NaN,!0,null,0,I),T.url=e,T.colorbarVisible=A,T}static async createChunkedZarr(e,i){const r=new ht;return r.zarrHelper=await f0.create(r,e,{url:e,level:i.level,maxVolumeSize:i.maxVolumeSize,maxTextureSize:i.maxTextureSize,channel:i.channel,cacheSize:i.cacheSize,convertUnitsToMm:i.convertUnitsToMm}),i.zarrCenterMM&&(r.zarrHelper.setWorldCenter(i.zarrCenterMM),r._hasExplicitZarrCenter=!0),i.colormap&&(r._colormap=i.colormap),i.opacity!==void 0&&(r._opacity=i.opacity),r.url=e,r}static async readFileAsync(e,i=NaN){return Gh(e,i)}static async loadFromFile({file:e,name:i="",colormap:r="",opacity:s=1,urlImgData:n=null,cal_min:a=NaN,cal_max:o=NaN,trustCalMinMax:l=!0,percentileFrac:c=.02,ignoreZeroVoxels:h=!1,useQFormNotSForm:d=!1,colormapNegative:f="",frame4D:u=0,limitFrames4D:m=NaN,imageType:p=j.UNKNOWN}){let g=null,x=[];try{if(Array.isArray(e))x=await Promise.all(e.map(y=>this.readFileAsync(y)));else{if(isNaN(m))x=await this.readFileAsync(e);else{const y=await this.readFileAsync(e,512),v=new Uint8Array(y);if(!(v[0]===92&&v[1]===1||v[1]===92&&v[0]===1))x=await this.readFileAsync(e);else{const w=await Nt(y);if(!w)throw new Error("could not read nifti header");const C=w.numBitsPerVoxel/8,M=[1,2,3].reduce((S,U)=>S*(w.dims[U]>1?w.dims[U]:1),1),T=[4,5,6].reduce((S,U)=>S*(w.dims[U]>1?w.dims[U]:1),1),E=Math.max(Math.min(m,T),1),I=w.vox_offset+E*M*C;x=await this.readFileAsync(e,I)}}i=e.name}let A=null;n&&(A=await this.readFileAsync(n)),g=await this.new(x,i,r,s,A,a,o,l,c,h,d,f,u,p,NaN,NaN,!0,null,0,null),g.fileObject=e}catch(A){throw F.error(A),new Error("could not build NVImage")}if(g===null)throw new Error("could not build NVImage");return g}static createNiftiArray(e=[256,256,256],i=[1,1,1],r=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],s=2,n=new Uint8Array){return th(e,i,r,s,n)}static createNiftiHeader(e=[256,256,256],i=[1,1,1],r=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],s=2){return yn(e,i,r,s)}getVolumeData(e=[-1,0,0],i=[0,0,0],r="same"){return sh(this,e,i,r)}setVolumeData(e=[-1,0,0],i=[0,0,0],r=new Uint8Array){nh(this,e,i,r)}static async loadFromBase64({base64:e,name:i="",colormap:r="",opacity:s=1,cal_min:n=NaN,cal_max:a=NaN,trustCalMinMax:o=!0,percentileFrac:l=.02,ignoreZeroVoxels:c=!1,useQFormNotSForm:h=!1,colormapNegative:d="",frame4D:f=0,imageType:u=j.UNKNOWN,cal_minNeg:m=NaN,cal_maxNeg:p=NaN,colorbarVisible:g=!0,colormapLabel:x=null}){let A=null;try{const y=Yh(e);A=await this.new(y,i,r,s,null,n,a,o,l,c,h,d,f,u,m,p,g,x,0,null)}catch(y){F.debug(y)}if(A===null)throw new Error("could not load NVImage");return A}clone(){const e=new ht;return e.id=di(),e.hdr=Object.assign({},this.hdr),e.img=this.img.slice(),e.calculateRAS(),e.calMinMax(),e}zeroImage(){this.img.fill(0)}getImageMetadata(){return Xh(this)}static zerosLike(e,i="same"){const r=e.clone();return r.zeroImage(),i==="uint8"&&(r.img=Uint8Array.from(r.img),r.hdr.datatypeCode=2,r.hdr.numBitsPerVoxel=8),i==="float32"&&(r.img=Float32Array.from(r.img),r.hdr.datatypeCode=16,r.hdr.numBitsPerVoxel=32),r}getValue(e,i,r,s=0,n=!1){return rh(this,e,i,r,s,n)}getValues(e,i,r,s=0,n=!1){return Mn(this,e,i,r,s,n)}applyOptionsUpdate(e){Kh(this,e)}getImageOptions(){return Wh(this)}toUint8Array(e=null){return bn(this,e)}convertVox2Frac(e){return Dh(this,e)}convertFrac2Vox(e){return Th(this,e)}convertFrac2MM(e,i=!1){return Sh(this,e,i)}convertMM2Frac(e,i=!1){return Eh(this,e,i)}};function Ln(t){return typeof t=="number"&&Number.isFinite(t)}function u0(t,e=12){if(!Ln(t))return t;const r=1e-9*Math.max(1,Math.abs(t)),s=Number(t.toFixed(e));return Math.abs(t-s)<=r?s:t}function dt(t,e=12){return t.map(i=>Array.isArray(i)?dt(i,e):Ln(i)?u0(i,e):i)}function Ri(t,e){return typeof e=="number"?Number.isNaN(e)?"NaN":e===1/0?"infinity":e===-1/0?"-infinity":e:e}function Re(t){if(t!=null){if(Array.isArray(t))return t.slice();if(ArrayBuffer.isView(t))try{return Array.from(t)}catch{}if(typeof t=="object"){if(Array.isArray(t.data))return t.data.slice();if(t.buffer&&Array.isArray(t.buffer.data))return t.buffer.data.slice();const e=Object.keys(t).filter(i=>/^\d+$/.test(i)).map(i=>Number(i)).sort((i,r)=>i-r);if(e.length>0)try{return e.map(i=>t[String(i)])}catch{}for(const i of["_data","source","values","elements","items"])if(Array.isArray(t[i]))return t[i].slice()}try{const e=Array.from(t);if(Array.isArray(e))return e}catch{}}}function oi(t){if(!t||typeof t!="object")return t;const e={...t||{}};if((e.pts===void 0||e.pts===null)&&(e.vertices!==void 0||e.positions!==void 0||e.verts!==void 0)){const i=[e.vertices,e.positions,e.verts];for(const r of i){const s=Re(r);if(s&&s.length>0){e.pts=dt(s);break}}}else if(e.pts!=null&&!Array.isArray(e.pts)&&ArrayBuffer.isView(e.pts)){const i=Re(e.pts);i&&(e.pts=dt(i))}else Array.isArray(e.pts)&&(e.pts=dt(e.pts));if((e.tris===void 0||e.tris===null)&&(e.indices!==void 0||e.faces!==void 0||e.cells!==void 0)){const i=[e.indices,e.faces,e.cells];for(const r of i){const s=Re(r);if(s&&s.length>0){e.tris=s;break}}}else if(e.tris!=null&&!Array.isArray(e.tris)&&ArrayBuffer.isView(e.tris)){const i=Re(e.tris);i&&(e.tris=i)}if((e.rgba255===void 0||e.rgba255===null)&&(e.rgba!==void 0||e.color!==void 0||e.colors!==void 0)){const i=[e.rgba,e.color,e.colors];for(const r of i){const s=Re(r);if(s&&s.length>0){e.rgba255=s;break}}}else if(e.rgba255!=null&&!Array.isArray(e.rgba255)&&ArrayBuffer.isView(e.rgba255)){const i=Re(e.rgba255);i&&(e.rgba255=i)}if(e.offsetPt0!=null&&!Array.isArray(e.offsetPt0)){const i=Re(e.offsetPt0);i&&(e.offsetPt0=i)}return Array.isArray(e.nodes)&&(e.nodes=e.nodes.length>0&&typeof e.nodes[0]=="object"?e.nodes.map(i=>({...i})):e.nodes.slice()),Array.isArray(e.edges)&&(e.edges=e.edges.length>0&&typeof e.edges[0]=="object"?e.edges.map(i=>({...i})):e.edges.slice()),Array.isArray(e.layers)&&(e.layers=e.layers.map(i=>{if(!i||typeof i!="object")return i;const r={...i||{}};"colorMap"in r&&("colormap"in r||(r.colormap=r.colorMap),delete r.colorMap),"colorMapNegative"in r&&("colormapNegative"in r||(r.colormapNegative=r.colorMapNegative),delete r.colorMapNegative);for(const s of["global_min","global_max","cal_min","cal_max","cal_minNeg","cal_maxNeg"])if(typeof r[s]=="string"){const n=r[s];if(n==="infinity")r[s]=1/0;else if(n==="-infinity")r[s]=-1/0;else if(n==="NaN")r[s]=NaN;else{const a=Number(n);Number.isNaN(a)||(r[s]=a)}}if(r.values!=null&&!Array.isArray(r.values)){const s=Re(r.values);s&&(r.values=dt(s))}else Array.isArray(r.values)&&(r.values=dt(r.values));if(r.atlasValues!=null&&!Array.isArray(r.atlasValues)){const s=Re(r.atlasValues);s&&(r.atlasValues=s)}return r})),e}function m0(t){if(typeof t!="string")return;if(t.trim().length===0)return t;try{const i=JSON.parse(t);if(Array.isArray(i)&&i.length>0&&typeof i[0]=="object"&&i[0]!==null&&"0"in i[0]&&"1"in i[0])try{const n=ul(i);if(Array.isArray(n)){const a=n.map(o=>oi(o));return JSON.stringify(a,Ri)}}catch(n){console.warn("legacy-migrate: structured-clone deserialize failed",n)}if(!Array.isArray(i)){const n=["value","data","0"];for(const a of n)if(i&&Array.isArray(i[a])){const l=i[a].map(c=>oi(c));return JSON.stringify(l,Ri)}return t}const s=i.map(n=>oi(n));return JSON.stringify(s,Ri)}catch{return t}}function Vi(t){if(!t||typeof t!="object")return t;const e={...t||{}};if("colorMap"in e&&!("colormap"in e)&&(e.colormap=e.colorMap),"colorMapNegative"in e&&!("colormapNegative"in e)&&(e.colormapNegative=e.colorMapNegative),Array.isArray(e.imageOptionsArray)&&(e.imageOptionsArray=e.imageOptionsArray.map(i=>{if(!i||typeof i!="object")return i;const r={...i||{}};for(const s of["cal_min","cal_max","cal_minNeg","cal_maxNeg"])if(typeof r[s]=="string")if(r[s]==="infinity")r[s]=1/0;else if(r[s]==="-infinity")r[s]=-1/0;else if(r[s]==="NaN")r[s]=NaN;else{const n=Number(r[s]);Number.isNaN(n)||(r[s]=n)}if(r.colormap&&typeof r.colormap!="string"&&!Array.isArray(r.colormap)){const s=Re(r.colormap);s&&(r.colormap=s)}if(r.colormapNegative&&typeof r.colormapNegative!="string"&&!Array.isArray(r.colormapNegative)){const s=Re(r.colormapNegative);s&&(r.colormapNegative=s)}return r})),typeof e.meshesString=="string"&&e.meshesString.trim().length>0){const i=m0(e.meshesString);typeof i=="string"&&(e.meshesString=i)}if(e.labels&&!Array.isArray(e.labels))try{e.labels=Array.from(e.labels)}catch{}if(e.connectomes&&!Array.isArray(e.connectomes))try{e.connectomes=Array.from(e.connectomes)}catch{}if(e.encodedImageBlobs&&!Array.isArray(e.encodedImageBlobs))try{e.encodedImageBlobs=Array.from(e.encodedImageBlobs)}catch{}return e}function ot(t){if(t!==void 0)return t===null?null:Number.isFinite(t)?t:t===1/0?"infinity":t===-1/0?"-infinity":"NaN"}function Ne(t){if(t===void 0)return;if(t===null)return null;if(typeof t=="number")return t;if(t==="NaN")return NaN;if(t==="infinity")return 1/0;if(t==="-infinity")return-1/0;const e=Number(t);return Number.isNaN(e)?NaN:e}function p0(t){if(t!=null){if(t instanceof Float32Array)return t;if(Array.isArray(t))return new Float32Array(t);if(ArrayBuffer.isView(t))return new Float32Array(Array.from(t));try{return new Float32Array(Array.from(t))}catch{return}}}function g0(t){if(t!=null){if(t instanceof Uint32Array)return t;if(Array.isArray(t))return new Uint32Array(t);if(ArrayBuffer.isView(t))return new Uint32Array(Array.from(t));try{return new Uint32Array(Array.from(t))}catch{return}}}function A0(t){if(t!=null){if(t instanceof Uint8Array)return t;if(Array.isArray(t))return new Uint8Array(t);if(ArrayBuffer.isView(t))return new Uint8Array(Array.from(t));try{return new Uint8Array(Array.from(t))}catch{return}}}function As(t,e){if(typeof e!="function"&&typeof e!="symbol")return ArrayBuffer.isView(e)?e instanceof DataView?Array.from(new Uint8Array(e.buffer,e.byteOffset,e.byteLength)):Array.from(e):e instanceof ArrayBuffer?Array.from(new Uint8Array(e)):e}var lr=class kn{static decodeOptsFromJSON(e){if(e==null)return;const i=s=>{if(s!==void 0){if(s===null)return null;if(typeof s=="number")return s;if(typeof s=="string")return s==="NaN"?NaN:s==="infinity"?1/0:s==="-infinity"?-1/0:s;if(Array.isArray(s))return s.map(n=>i(n));if(typeof s=="object"){const n={};for(const a of Object.keys(s))n[a]=i(s[a]);return n}return s}},r={};for(const s of Object.keys(e)){const n=e[s];n!==void 0&&(r[s]=i(n))}return r}static serializeDocument(e,i=!0,r=!0){const s={encodedImageBlobs:[],previewImageDataURL:e.previewImageDataURL??"",imageOptionsMap:new Map};s.sceneData={...e.scene?.sceneData??{}},s.opts=e.opts??{},s.labels=Array.isArray(e.labels)?e.labels.map(c=>{const h={...c||{}};return delete h.onClick,h}):[],s.customData=e.customData??"",s.completedMeasurements=e.completedMeasurements?e.completedMeasurements.slice():[],s.completedAngles=e.completedAngles?e.completedAngles.slice():[];const n=[],a=e.volumes??[];if(a.length)for(let c=0;c<a.length;c++){const h=a[c];let d=e.getImageOptions?e.getImageOptions(h):null;if(d===null?d={name:h?.name??"",colormap:h?._colormap??"gray",opacity:h?._opacity??1,cal_min:h?.cal_min??NaN,cal_max:h?.cal_max??NaN,trustCalMinMax:h?.trustCalMinMax??!0,percentileFrac:h?.percentileFrac??.02,ignoreZeroVoxels:h?.ignoreZeroVoxels??!1,imageType:h?.imageType??j.NII,frame4D:h?.frame4D??0,limitFrames4D:h?.limitFrames4D??NaN,url:h?.url??"",urlImageData:h?.urlImgData??"",cal_minNeg:h?.cal_minNeg??NaN,cal_maxNeg:h?.cal_maxNeg??NaN,colorbarVisible:h?.colorbarVisible??!0,colormapNegative:h?.colormapNegative??"",colormapType:h?.colormapType??0}:"imageType"in d||(d.imageType=j.NII),d.colormap=h.colormap,d.colormapLabel=h.colormapLabel,d.opacity=h.opacity,d.cal_max=h.cal_max??NaN,d.cal_min=h.cal_min??NaN,d.colormapNegative=h.colormapNegative??"",d.cal_minNeg=h.cal_minNeg??NaN,d.cal_maxNeg=h.cal_maxNeg??NaN,d.colorbarVisible=h.colorbarVisible??!0,d.colormapType=h.colormapType??0,n.push(d),i){const f=H.uint8tob64(h.toUint8Array());s.encodedImageBlobs.push(f)}s.imageOptionsMap.set(h.id,c)}s.imageOptionsArray=n;const o=[],l=e.meshes||[];s.connectomes=[];for(const c of l){if(!c||typeof c!="object")continue;if(c.type==="connectome"){try{s.connectomes.push(JSON.stringify(c.json()))}catch(f){F.warn("serializeDocument: failed connectome export",f)}continue}const h=(c.layers||[]).map(f=>{const u={name:f?.name,key:f?.key,url:f?.url,headers:f?.headers,opacity:f?.opacity,colormap:f?.colorMap??f?.colormap,colormapNegative:f?.colorMapNegative??f?.colormapNegative,colormapInvert:f?.colormapInvert,colormapLabel:f?.colormapLabel,useNegativeCmap:f?.useNegativeCmap,global_min:ot(f?.global_min),global_max:ot(f?.global_max),cal_min:ot(f?.cal_min),cal_max:ot(f?.cal_max),cal_minNeg:ot(f?.cal_minNeg),cal_maxNeg:ot(f?.cal_maxNeg),isAdditiveBlend:f?.isAdditiveBlend,frame4D:f?.frame4D,nFrame4D:f?.nFrame4D,outlineBorder:f?.outlineBorder,isTransparentBelowCalMin:f?.isTransparentBelowCalMin,colormapType:f?.colormapType,base64:f?.base64,colorbarVisible:f?.colorbarVisible,showLegend:f?.showLegend};if(f?.values!=null){const m=Array.isArray(f.values)?f.values.slice():Array.from(f.values||[]);u.values=m.map(p=>{const g=Number(p);return Number.isFinite(g)?Math.round(g*1e12)/1e12:g})}return f?.atlasValues!=null&&(u.atlasValues=Array.isArray(f.atlasValues)?f.atlasValues.slice():Array.from(f.atlasValues||[])),Array.isArray(f?.labels)?u.labels=f.labels.map(m=>({...m||{}})):f?.labels!=null&&(u.labels=Array.from(f.labels||[])),u}),d={...Object.assign({},c||{}),rgba255:Array.from(c.rgba255||[]),layers:h,edges:Array.isArray(c?.edges)?c.edges.map(f=>({...f||{}})):[],nodes:Array.isArray(c?.nodes)?c.nodes.map(f=>({...f||{}})):c?.nodes,offsetPt0:Array.isArray(c?.offsetPt0)?[...c.offsetPt0]:c?.offsetPt0};Array.isArray(c.offsetPt0)&&c.offsetPt0.length>0&&(d.offsetPt0=Array.isArray(c.offsetPt0)?[...c.offsetPt0]:c.offsetPt0,Array.isArray(c.fiberGroupColormap)&&(d.fiberGroupColormap=[...c.fiberGroupColormap]),Array.isArray(c.fiberColor)&&(d.fiberColor=Array.from(c.fiberColor)),d.fiberDither=c.fiberDither,d.fiberRadius=c.fiberRadius,d.colormap=c.colormap),o.push(d)}try{s.meshesString=JSON.stringify(o,As)}catch(c){F.warn("serializeDocument: JSON.stringify failed for meshes",c);const h=[];for(let d=0;d<o.length;d++)try{h.push(JSON.stringify(o[d],As))}catch(f){F.error("serializeDocument: failed to serialize mesh at index",d,f,o[d]),h.push(JSON.stringify({name:o[d]?.name??"unknown",id:o[d]?.id??null}))}s.meshesString=`[${h.join(",")}]`}return r&&e.drawBitmap?s.encodedDrawingBlob=H.uint8tob64(e.drawBitmap):s.encodedDrawingBlob=e.encodedDrawingBlob??"",s.title=e.title??"untitled",s.customData=e.customData??"",s.labels=Array.isArray(e.labels)?e.labels.map(c=>{const h={...c||{}};return delete h.onClick,h}):[],s.completedMeasurements=(e.completedMeasurements||[]).map(c=>({...c,startMM:Array.isArray(c.startMM)?[...c.startMM]:c.startMM,endMM:Array.isArray(c.endMM)?[...c.endMM]:c.endMM})),s.completedAngles=(e.completedAngles||[]).map(c=>({...c,firstLineMM:{start:Array.isArray(c.firstLineMM?.start)?[...c.firstLineMM.start]:c.firstLineMM?.start,end:Array.isArray(c.firstLineMM?.end)?[...c.firstLineMM.end]:c.firstLineMM?.end},secondLineMM:{start:Array.isArray(c.secondLineMM?.start)?[...c.secondLineMM.start]:c.secondLineMM?.start,end:Array.isArray(c.secondLineMM?.end)?[...c.secondLineMM.end]:c.secondLineMM?.end}})),s.sceneData=s.sceneData??{...e.scene?.sceneData??{}},s.opts=s.opts??(e.opts?{...e.opts}:{}),s}static async rehydrateImages(e){const i=[],r=await Vi(e),s=r.encodedImageBlobs??[],n=r.imageOptionsArray??[];for(let a=0;a<n.length;a++){const o={...n[a]||{}};try{const l=s[a];if(!l){F.debug("NVSerializer.rehydrateImages: no blob for index",a);continue}const c=await H.b64toUint8(l);if(!c){F.warn("NVSerializer.rehydrateImages: b64toUint8 returned empty for index",a);continue}const h=o.name??o.url??`image-${a}`;let d=o.colormap??o.colorMap??"";typeof d!="string"&&(typeof o.colorMap=="string"?d=o.colorMap:d="");const f=o.opacity??1,u=o.pairedImgData?typeof o.pairedImgData=="string"?(await H.b64toUint8(o.pairedImgData)).buffer:o.pairedImgData:null,m=Ne(o.cal_min),p=Ne(o.cal_max),g=o.trustCalMinMax??!0,x=o.percentileFrac??.02,A=o.ignoreZeroVoxels??!1,y=o.useQFormNotSForm??!1,v=o.colormapNegative??"",b=o.frame4D??0,w="imageType"in o&&typeof o.imageType=="number"?o.imageType:o.imageType??j.UNKNOWN,C=Ne(o.cal_minNeg),M=Ne(o.cal_maxNeg),T=o.colorbarVisible??!0,E=o.colormapLabel??null,I=o.colormapType??0,S=o.zarrData??null;console.log(`Image ${a} buffer length: ${c.byteLength}`),!c.some(R=>R!==0)&&console.error(`CRITICAL: Base64 decoding for ${h} resulted in an all-zero array!`);const B=c.slice().buffer,V=await Me.new(B,h,d,f,u,m,p,g,x,A,y,v,b,w,C,M,T,E,I,S);i.push(V)}catch(l){F.warn("NVSerializer.rehydrateImages: failed for index",a,l)}}return i}static async rehydrateMeshes(e,i,r=!1){const s=[],a=(await Vi(e)).meshesString??"[]";let o=[];try{o=JSON.parse(a)}catch(l){console.warn("NVSerializer.rehydrateMeshes: failed to parse meshesString",l),o=[]}for(let l=0;l<o.length;l++){let c=o[l]||{};try{if(c=oi(c),Array.isArray(c.layers)){for(const g of c.layers)if(g){if("colorMap"in g&&!("colormap"in g)&&(g.colormap=g.colorMap,delete g.colorMap),"colorMapNegative"in g&&!("colormapNegative"in g)&&(g.colormapNegative=g.colorMapNegative,delete g.colorMapNegative),g.global_min=Ne(g.global_min),g.global_max=Ne(g.global_max),g.cal_min=Ne(g.cal_min),g.cal_max=Ne(g.cal_max),g.cal_minNeg=Ne(g.cal_minNeg),g.cal_maxNeg=Ne(g.cal_maxNeg),g.values!=null&&!Array.isArray(g.values))try{g.values=Array.from(g.values)}catch{}if(g.atlasValues!=null&&!Array.isArray(g.atlasValues))try{g.atlasValues=Array.from(g.atlasValues)}catch{}}}const h=A0(c.rgba255)??new Uint8Array([255,255,255,255]),d=p0(c.pts);let f=g0(c.tris);Array.isArray(c.nodes)&&(c.nodes=c.nodes.length>0&&typeof c.nodes[0]=="object"?c.nodes.map(g=>({...g})):c.nodes.slice()),Array.isArray(c.edges)&&(c.edges=c.edges.length>0&&typeof c.edges[0]=="object"?c.edges.map(g=>({...g})):c.edges.slice());const u=c.id!==void 0?c.id:null;if(!i){s.push(c);continue}Array.isArray(c.offsetPt0)&&c.offsetPt0.length>0&&(f=new Uint32Array(c.offsetPt0),h&&(h[3]=0));const m=new Uint8Array(Array.isArray(h)?h:Array.from(h)),p=new mt(d,f,c.name,m,c.opacity,c.visible,i,c.connectome,c.dpg,c.dps,c.dpv);if(u!==null&&(p.id=u),Array.isArray(c.offsetPt0)&&c.offsetPt0.length>0&&(p.fiberGroupColormap=c.fiberGroupColormap,p.fiberColor=c.fiberColor?c.fiberColor:void 0,p.fiberDither=c.fiberDither,p.fiberRadius=c.fiberRadius,p.colormap=c.colormap),p.meshShaderIndex=c.meshShaderIndex,p.layers=c.layers||[],r)try{p.updateMesh(i)}catch(g){console.warn("NVSerializer.rehydrateMeshes: updateMesh failed for idx",l,g)}s.push(p)}catch(h){console.warn("NVSerializer.rehydrateMeshes: failed idx",l,h),s.push(c)}}try{return Array.isArray(s)?s:(console.warn("NVSerializer.rehydrateMeshes: unexpected non-array output, coercing to array",{typeofOut:typeof s,isArray:Array.isArray(s),outPreview:s&&(typeof s=="object"?Object.keys(s).slice(0,10):s)}),s?[s]:[])}catch(l){return console.error("NVSerializer.rehydrateMeshes: final-return error",l),[]}}static async deserializeDocument(e){const i=await Vi(e),r=new St;Object.assign(r.data,{...i,imageOptionsArray:i.imageOptionsArray??[],encodedImageBlobs:i.encodedImageBlobs??[],labels:i.labels??[],meshOptionsArray:i.meshOptionsArray??[],connectomes:i.connectomes??[],encodedDrawingBlob:i.encodedDrawingBlob??"",previewImageDataURL:i.previewImageDataURL??"",customData:i.customData??"",title:i.title??"untitled"});const s=kn.decodeOptsFromJSON(i.opts);r.data.opts={...ke,...s||{}},r.data.opts.meshThicknessOn2D==="infinity"&&(r.data.opts.meshThicknessOn2D=1/0),r.scene.sceneData={...mi,...i.sceneData||{}};const n=i.sceneData||{};return n.clipPlane&&!n.clipPlanes&&(r.scene.sceneData.clipPlanes=[n.clipPlane]),n.clipPlaneDepthAziElev&&!n.clipPlaneDepthAziElevs&&(r.scene.sceneData.clipPlaneDepthAziElevs=[n.clipPlaneDepthAziElev]),i.completedMeasurements&&(r.completedMeasurements=i.completedMeasurements.map(a=>({...a,startMM:Ve(a.startMM),endMM:Ve(a.endMM)}))),i.completedAngles&&(r.completedAngles=i.completedAngles.map(a=>({...a,firstLineMM:{start:Ve(a.firstLineMM.start),end:Ve(a.firstLineMM.end)},secondLineMM:{start:Ve(a.secondLineMM.start),end:Ve(a.secondLineMM.end)}}))),r.data.connectomes=i.connectomes??[],r.data.encodedDrawingBlob=i.encodedDrawingBlob??"",r.data.previewImageDataURL=i.previewImageDataURL??"",r}},xs=lr,x0=(t=>(t[t.AXIAL=0]="AXIAL",t[t.CORONAL=1]="CORONAL",t[t.SAGITTAL=2]="SAGITTAL",t[t.MULTIPLANAR=3]="MULTIPLANAR",t[t.RENDER=4]="RENDER",t))(x0||{}),v0=(t=>(t[t.PEN=0]="PEN",t[t.RECTANGLE=1]="RECTANGLE",t[t.ELLIPSE=2]="ELLIPSE",t))(v0||{}),w0=(t=>(t[t.NEVER=0]="NEVER",t[t.ALWAYS=1]="ALWAYS",t[t.AUTO=2]="AUTO",t))(w0||{}),y0=(t=>(t[t.AUTO=0]="AUTO",t[t.COLUMN=1]="COLUMN",t[t.GRID=2]="GRID",t[t.ROW=3]="ROW",t))(y0||{}),On=(t=>(t[t.none=0]="none",t[t.contrast=1]="contrast",t[t.measurement=2]="measurement",t[t.pan=3]="pan",t[t.slicer3D=4]="slicer3D",t[t.callbackOnly=5]="callbackOnly",t[t.roiSelection=6]="roiSelection",t[t.angle=7]="angle",t[t.crosshair=8]="crosshair",t[t.windowing=9]="windowing",t))(On||{}),ke={textHeight:-1,fontSizeScaling:.4,fontMinPx:13,colorbarHeight:.05,colorbarWidth:-1,showColorbarBorder:!0,crosshairWidth:1,crosshairWidthUnit:"voxels",crosshairGap:0,rulerWidth:4,show3Dcrosshair:!1,backColor:[0,0,0,1],crosshairColor:[1,0,0,1],fontColor:[.5,.5,.5,1],selectionBoxColor:[1,1,1,.5],clipPlaneColor:[.7,0,.7,.5],isClipPlanesCutaway:!1,isClipAllVolumes:!1,paqdUniforms:[.3,.5,.5,1],rulerColor:[1,0,0,.8],colorbarMargin:.05,trustCalMinMax:!0,clipPlaneHotKey:"KeyC",cycleClipPlaneHotKey:"KeyP",viewModeHotKey:"KeyV",doubleTouchTimeout:500,longTouchTimeout:1e3,keyDebounceTime:50,isNearestInterpolation:!1,isResizeCanvas:!0,atlasOutline:0,atlasActiveIndex:0,isRuler:!1,isColorbar:!1,isOrientCube:!1,tileMargin:0,multiplanarPadPixels:0,multiplanarForceRender:!1,multiplanarEqualSize:!1,multiplanarShowRender:2,isRadiologicalConvention:!1,meshThicknessOn2D:1/0,dragMode:1,dragModePrimary:8,mouseEventConfig:void 0,touchEventConfig:void 0,yoke3Dto2DZoom:!1,isDepthPickMesh:!1,isCornerOrientationText:!1,isOrientationTextVisible:!0,showAllOrientationMarkers:!1,heroImageFraction:0,heroSliceType:4,sagittalNoseLeft:!1,isSliceMM:!1,isV1SliceShader:!1,forceDevicePixelRatio:0,logLevel:"info",loadingText:"loading ...",isForceMouseClickToVoxelCenters:!1,dragAndDropEnabled:!0,drawingEnabled:!1,penValue:1,penType:0,floodFillNeighbors:6,isFilledPen:!1,thumbnail:"",maxDrawUndoBitmaps:8,sliceType:3,meshXRay:0,isAntiAlias:null,limitFrames4D:NaN,isAdditiveBlend:!1,showLegend:!0,legendBackgroundColor:[.3,.3,.3,.5],legendTextColor:[1,1,1,1],multiplanarLayout:0,renderOverlayBlend:1,sliceMosaicString:"",centerMosaic:!1,penSize:1,interactive:!0,clickToSegment:!1,clickToSegmentRadius:3,clickToSegmentBright:!0,clickToSegmentAutoIntensity:!1,clickToSegmentIntensityMax:NaN,clickToSegmentIntensityMin:NaN,clickToSegmentPercent:0,clickToSegmentMaxDistanceMM:Number.POSITIVE_INFINITY,clickToSegmentIs2D:!1,selectionBoxLineThickness:4,selectionBoxIsOutline:!1,scrollRequiresFocus:!1,showMeasureUnits:!0,measureTextJustify:"center",measureTextColor:[1,0,0,1],measureLineColor:[1,0,0,1],measureTextHeight:.06,isAlphaClipDark:!1,gradientOrder:1,gradientOpacity:0,renderSilhouette:0,gradientAmount:0,invertScrollDirection:!1,is2DSliceShader:!1,bounds:null,showBoundsBorder:!1,boundsBorderColor:[1,1,1,1],windowingGainFactor:2,zarrCacheSize:1e3,zarrPrefetchRings:10,smoothDrawing:0},Nm={},mi={gamma:1,azimuth:110,elevation:10,crosshairPos:k(.5,.5,.5),clipPlanes:[[0,0,0,0]],clipPlaneDepthAziElevs:[[2,0,0]],volScaleMultiplier:1,pan2Dxyzmm:ae(0,0,0,1)},St=class cr{constructor(){D(this,"data",{title:"Untitled document",imageOptionsArray:[],meshOptionsArray:[],opts:{...ke},previewImageDataURL:"",labels:[],encodedImageBlobs:[],encodedDrawingBlob:""}),D(this,"scene"),D(this,"volumes",[]),D(this,"meshDataObjects"),D(this,"meshes",[]),D(this,"drawBitmap",null),D(this,"imageOptionsMap",new Map),D(this,"meshOptionsMap",new Map),D(this,"completedMeasurements",[]),D(this,"completedAngles",[]),D(this,"_optsProxy",null),D(this,"_optsChangeCallback",null),this.scene={onAzimuthElevationChange:()=>{},onZoom3DChange:()=>{},sceneData:{...mi,pan2Dxyzmm:ae(0,0,0,1),crosshairPos:k(.5,.5,.5)},get renderAzimuth(){return this.sceneData.azimuth},set renderAzimuth(e){this.sceneData.azimuth=e,this.onAzimuthElevationChange&&this.onAzimuthElevationChange(this.sceneData.azimuth,this.sceneData.elevation)},get renderElevation(){return this.sceneData.elevation},set renderElevation(e){this.sceneData.elevation=e,this.onAzimuthElevationChange&&this.onAzimuthElevationChange(this.sceneData.azimuth,this.sceneData.elevation)},get volScaleMultiplier(){return this.sceneData.volScaleMultiplier},set volScaleMultiplier(e){this.sceneData.volScaleMultiplier=e,this.onZoom3DChange(e)},get crosshairPos(){return this.sceneData.crosshairPos},set crosshairPos(e){this.sceneData.crosshairPos=e},get clipPlane(){return this.sceneData.clipPlanes[0]??[]},set clipPlane(e){this.sceneData.clipPlanes[0]=e},get clipPlanes(){return this.sceneData.clipPlanes},set clipPlanes(e){this.sceneData.clipPlanes=e},get clipPlaneDepthAziElevs(){return this.sceneData.clipPlaneDepthAziElevs},set clipPlaneDepthAziElevs(e){this.sceneData.clipPlaneDepthAziElevs=e},get pan2Dxyzmm(){return this.sceneData.pan2Dxyzmm},set pan2Dxyzmm(e){this.sceneData.pan2Dxyzmm=e},get gamma(){return this.sceneData.gamma},set gamma(e){this.sceneData.gamma=e}}}get title(){return this.data.title}get previewImageDataURL(){return this.data.previewImageDataURL}set previewImageDataURL(e){this.data.previewImageDataURL=e}set title(e){this.data.title=e}get imageOptionsArray(){return this.data.imageOptionsArray}get encodedImageBlobs(){return this.data.encodedImageBlobs}get encodedDrawingBlob(){return this.data.encodedDrawingBlob}get opts(){return this._optsProxy||this._createOptsProxy(),this._optsProxy}set opts(e){this.data.opts={...e},this._optsProxy=null}get labels(){return this.data.labels}set labels(e){this.data.labels=e}get customData(){return this.data.customData}set customData(e){this.data.customData=e}hasImage(e){return this.volumes.find(i=>i.id===e.id)!==void 0}hasImageFromUrl(e){return this.data.imageOptionsArray.find(i=>i.url===e)!==void 0}addImageOptions(e,i){if(!this.hasImage(e)&&!i.name)if(i.url){const s=/^(?:[a-z+]+:)?\/\//i.test(i.url)?new URL(i.url):new URL(i.url,window.location.href);i.name=s.pathname.split("/").pop(),i.name.toLowerCase().endsWith(".gz")&&(i.name=i.name.slice(0,-3)),i.name.toLowerCase().endsWith(".nii")||(i.name+=".nii")}else i.name="untitled.nii";i.imageType=j.NII,this.data.imageOptionsArray.push(i),this.imageOptionsMap.set(e.id,this.data.imageOptionsArray.length-1)}removeImage(e){if(this.imageOptionsMap.has(e.id)){const i=this.imageOptionsMap.get(e.id);this.data.imageOptionsArray.length>i&&this.data.imageOptionsArray.splice(i,1),this.imageOptionsMap.delete(e.id)}this.volumes=this.volumes.filter(i=>i.id!==e.id)}async fetchLinkedData(){if(this.data.encodedImageBlobs=[],!!this.imageOptionsArray?.length){for(const e of this.imageOptionsArray)if(e.url)try{const i=await fetch(e.url);if(!i.ok){console.warn("Failed to fetch image:",e.url);continue}const r=await i.arrayBuffer(),s=new Uint8Array(r),n=H.uint8tob64(s);this.data.encodedImageBlobs.push(n),console.info("fetch linked data fetched from ",e.url)}catch(i){console.warn(`Failed to fetch/encode image from ${e.url}:`,i)}}}getImageOptions(e){return this.imageOptionsMap.has(e.id)?this.data.imageOptionsArray[this.imageOptionsMap.get(e.id)]:null}json(e=!0,i=!0){return lr.serializeDocument(this,e,i)}async download(e,i,r={embedImages:!0}){const s=this.json(r.embedImages),n=JSON.stringify(s),a=i?"application/gzip":"application/json",o=i?await H.compressStringToArrayBuffer(n):n;H.download(o,e,a)}static async loadFromUrl(e){const r=await(await fetch(e)).arrayBuffer();let s;if(H.isArrayBufferCompressed(r)){const n=await H.decompressArrayBuffer(r);s=JSON.parse(n)}else{const n=new TextDecoder;s=JSON.parse(n.decode(r))}return cr.loadFromJSON(s)}static async loadFromFile(e){const i=await H.readFileAsync(e);let r;H.isArrayBufferCompressed(i)?r=await H.decompressArrayBuffer(i):r=new TextDecoder().decode(i);const s=JSON.parse(r);return cr.loadFromJSON(s)}static async loadFromJSON(e){return await lr.deserializeDocument(e)}setOptsChangeCallback(e){this._optsChangeCallback=e,this._optsProxy=null}removeOptsChangeCallback(){this._optsChangeCallback=null,this._optsProxy=null}_createOptsProxy(){const e=this.data.opts;this._optsProxy=new Proxy(e,{set:(i,r,s)=>{const n=i[r];return n!==s&&(i[r]=s,this._optsChangeCallback&&typeof r=="string"&&r in ke&&this._optsChangeCallback(r,s,n)),!0},get:(i,r)=>i[r]})}},vs=(t,e)=>{const i=Math.floor(Math.log(t)/Math.log(10)),r=t/Math.pow(10,i);let s;return e?r<1.5?s=1:r<3?s=2:r<7?s=5:s=10:r<=1?s=1:r<=2?s=2:r<=5?s=5:s=10,s*Math.pow(10,i)};function b0(t){return new Promise((e,i)=>{let r;t instanceof File?r=Promise.resolve(t):r=new Promise((s,n)=>{t.file(s,n)}),r.then(s=>{const n=new FileReader;n.onload=()=>{typeof n.result=="string"?e(n.result):i(new Error("Expected a string from FileReader.result"))},n.onerror=()=>{i(n.error??new Error("Unknown FileReader error"))},n.readAsDataURL(s)}).catch(s=>i(s))})}function C0(t){const 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undefined");n=k(s.extentsMin[0],s.extentsMin[1],s.extentsMin[2]),a=k(s.extentsMax[0],s.extentsMax[1],s.extentsMax[2]),e||(n=k(i[0].extentsMinOrtho[0],i[0].extentsMinOrtho[1],i[0].extentsMinOrtho[2]),a=k(i[0].extentsMaxOrtho[0],i[0].extentsMaxOrtho[1],i[0].extentsMaxOrtho[2]))}if(r.length>0){if(i.length<1){const l=r[0].extentsMin,c=r[0].extentsMax;n=k(l[0],l[1],l[2]),a=k(c[0],c[1],c[2])}for(let l=0;l<r.length;l++){const c=r[l].extentsMin,h=r[l].extentsMax,d=k(c[0],c[1],c[2]);ur(n,n,d);const f=k(h[0],h[1],h[2]);mr(a,a,f)}}const o=se();return ne(o,a,n),[n,a,o]}function zn(t,e){const{volumes:i,meshes:r,volumeObject3D:s,volIdx:n=0,isSliceMM:a=!1}=e;if(i.length<1){const o=k(.1,.5,.5),[l,c,h]=Br({volumes:i,meshes:r,volumeObject3D:s},a);return o[0]=(t[0]-l[0])/h[0],o[1]=(t[1]-l[1])/h[1],o[2]=(t[2]-l[2])/h[2],isFinite(o[0])||(o[0]=.5),isFinite(o[1])||(o[1]=.5),isFinite(o[2])||(o[2]=.5),o}return i[n].convertMM2Frac(t,a)}function wi(t,e){const{volumes:i,meshes:r,volumeObject3D:s,volIdx:n=0,isSliceMM:a=!1}=e,o=ae(t[0],t[1],t[2],1);if(i.length>0)return i[n].convertFrac2MM(t,a);{const[l,c]=Br({volumes:i,meshes:r,volumeObject3D:s},a),h=(d,f,u)=>d*(1-u)+f*u;o[0]=h(l[0],c[0],t[0]),o[1]=h(l[1],c[1],t[1]),o[2]=h(l[2],c[2],t[2])}return o}function S0(t,e,i=0){return e[i].convertVox2Frac(t)}function E0(t,e,i=0){return e.length<=i?k(0,0,0):e[i].convertFrac2Vox(t)}function I0(t,e){return H.vox2mm(t,e)}function F0(t,e){return e===1?he(t,[0,2,1]):e===2?he(t,[1,2,0]):t}function Ur(t,e,i,r,s){const{volumes:n,meshes:a,volumeObject3D:o,isSliceMM:l=!1,restrict0to1:c=!0}=s,h=k(-1,-1,-1),d=i[r],f=d.axCorSag;if(f>2)return h;const u=d.leftTopWidthHeight.slice();let m=!1;u[2]<0&&(m=!0,u[0]+=u[2],u[2]=-u[2]);let p=(t-u[0])/u[2];m&&(p=1-p);const g=1-(e-u[1])/u[3];if(p<0||p>1||g<0||g>1||d.AxyzMxy.length<4)return h;let x=k(0,0,0);x[0]=d.leftTopMM[0]+p*d.fovMM[0],x[1]=d.leftTopMM[1]+g*d.fovMM[1];const 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R0(t,e,i){const{volumes:r,meshes:s,volumeObject3D:n,isSliceMM:a=!1,sliceType:o}=i,l=wi(t,{volumes:r,meshes:s,volumeObject3D:n,isSliceMM:a});let c={index:-1,distance:1/0};for(let h=0;h<e.length;h++){const d=e[h],f=d.axCorSag;if(f>2||d.AxyzMxy.length<4)continue;let u=k(l[0],l[1],l[2]);f===1&&(u=he(u,[0,2,1])),f===2&&(u=he(u,[1,2,0]));const m=d.AxyzMxy,p=m[2]+m[4]*(u[1]-m[1])-m[3]*(u[0]-m[0]),g=Math.abs(u[2]-p),x=o===3?1:.1;if(g<c.distance&&(c={index:h,distance:g}),g<=x){const A=(u[0]-d.leftTopMM[0])/d.fovMM[0],y=(u[1]-d.leftTopMM[1])/d.fovMM[1];if(A>=0&&A<=1&&y>=0&&y<=1){const v=d.leftTopWidthHeight.slice();let b=!1;v[2]<0&&(b=!0,v[0]+=v[2],v[2]=-v[2]);let w=A;b&&(w=1-A);const C=1-y,M=v[0]+w*v[2],T=v[1]+C*v[3];return[M,T]}}}if(c.index>=0&&c.distance<2){const h=c.index,d=e[h],f=d.axCorSag;let u=k(l[0],l[1],l[2]);f===1&&(u=he(u,[0,2,1])),f===2&&(u=he(u,[1,2,0]));const m=d.AxyzMxy;u[2]=m[2]+m[4]*(u[1]-m[1])-m[3]*(u[0]-m[0]);const p=(u[0]-d.leftTopMM[0])/d.fovMM[0],g=(u[1]-d.leftTopMM[1])/d.fovMM[1];if(p>=-.1&&p<=1.1&&g>=-.1&&g<=1.1){const x=Math.max(0,Math.min(1,p)),A=Math.max(0,Math.min(1,g)),y=d.leftTopWidthHeight.slice();let v=!1;y[2]<0&&(v=!0,y[0]+=y[2],y[2]=-y[2]);let b=x;v&&(b=1-x);const w=1-A,C=y[0]+b*y[2],M=y[1]+w*y[3];return[C,M]}}return null}function V0(t,e,i){const{volumes:r,meshes:s,volumeObject3D:n,isSliceMM:a=!1,preferredSliceType:o}=i,l=wi(t,{volumes:r,meshes:s,volumeObject3D:n,isSliceMM:a});let c={index:-1,distance:1/0};for(let h=0;h<e.length;h++){const d=e[h],f=d.axCorSag;if(f>2||d.AxyzMxy.length<4||o!==void 0&&f!==o)continue;let u=k(l[0],l[1],l[2]);f===1&&(u=he(u,[0,2,1])),f===2&&(u=he(u,[1,2,0]));const m=d.AxyzMxy,p=m[2]+m[4]*(u[1]-m[1])-m[3]*(u[0]-m[0]),g=Math.abs(u[2]-p);if(g<c.distance&&(c={index:h,distance:g}),g<=.1){const A=(u[0]-d.leftTopMM[0])/d.fovMM[0],y=(u[1]-d.leftTopMM[1])/d.fovMM[1];if(A>=0&&A<=1&&y>=0&&y<=1){const v=d.leftTopWidthHeight.slice();let b=!1;v[2]<0&&(b=!0,v[0]+=v[2],v[2]=-v[2]);let w=A;b&&(w=1-A);const C=1-y,M=v[0]+w*v[2],T=v[1]+C*v[3];return{pos:[M,T],tileIndex:h}}}}if(c.index>=0&&c.distance<2){const h=c.index,d=e[h],f=d.axCorSag;let u=k(l[0],l[1],l[2]);f===1&&(u=he(u,[0,2,1])),f===2&&(u=he(u,[1,2,0]));const m=d.AxyzMxy;u[2]=m[2]+m[4]*(u[1]-m[1])-m[3]*(u[0]-m[0]);const p=(u[0]-d.leftTopMM[0])/d.fovMM[0],g=(u[1]-d.leftTopMM[1])/d.fovMM[1];if(p>=-.1&&p<=1.1&&g>=-.1&&g<=1.1){const x=Math.max(0,Math.min(1,p)),A=Math.max(0,Math.min(1,g)),y=d.leftTopWidthHeight.slice();let v=!1;y[2]<0&&(v=!0,y[0]+=y[2],y[2]=-y[2]);let b=x;v&&(b=1-x);const w=1-A,C=y[0]+b*y[2],M=y[1]+w*y[3];return{pos:[C,M],tileIndex:h}}}return null}var P0=function(t,e,i){const r=t.createShader(t.VERTEX_SHADER);t.shaderSource(r,e),t.compileShader(r);const s=t.createShader(t.FRAGMENT_SHADER);t.shaderSource(s,i),t.compileShader(s);const n=t.createProgram();if(t.attachShader(n,r),t.attachShader(n,s),t.linkProgram(n),!t.getProgramParameter(n,t.LINK_STATUS))throw console.log(t.getProgramInfoLog(n)),t.getShaderParameter(r,t.COMPILE_STATUS)||console.log("Vertex shader compilation error:",t.getShaderInfoLog(r)),t.getShaderParameter(s,t.COMPILE_STATUS)||console.log("Fragment shader compilation error:",t.getShaderInfoLog(s)),F.error(t.getProgramInfoLog(n)),new Error("Shader failed to link, see console for log");return n},ee=class{constructor(t,e,i){D(this,"program"),D(this,"uniforms",{}),D(this,"isMatcap"),D(this,"isCrosscut"),this.program=P0(t,e,i);const r=/uniform[^;]+[ ](\w+);/g,s=/uniform[^;]+[ ](\w+);/,n=e.match(r),a=i.match(r);n&&n.forEach(o=>{const l=o.match(s);this.uniforms[l[1]]=-1}),a&&a.forEach(o=>{const l=o.match(s);this.uniforms[l[1]]=-1});for(const o in this.uniforms)this.uniforms[o]=t.getUniformLocation(this.program,o)}use(t){t.useProgram(this.program)}},Et=`#version 300 es
+#line 4
+layout(location=0) in vec3 pos;
+layout(location=1) in vec3 texCoords;
+uniform mat4 mvpMtx;
+out vec3 vColor;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vColor = texCoords;
+}`,Rr=`
+	vec4 drawColor(float scalar, float drawOpacity) {
+		float nlayer = float(textureSize(colormap, 0).y);
+		float layer = (nlayer - 0.5) / nlayer;
+		vec4 dcolor = texture(colormap, vec2((scalar * 255.0)/256.0 + 0.5/256.0, layer)).rgba;
+		dcolor.a *= drawOpacity;
+		return dcolor;
+}`,zt=`vec3 GetBackPosition(vec3 startPositionTex) {
+	vec3 startPosition = startPositionTex * volScale;
+	vec3 invR = 1.0 / rayDir;
+	vec3 tbot = invR * (vec3(0.0)-startPosition);
+	vec3 ttop = invR * (volScale-startPosition);
+	vec3 tmax = max(ttop, tbot);
+	vec2 t = min(tmax.xx, tmax.yz);
+	vec3 endPosition = startPosition + (rayDir * min(t.x, t.y));
+	//convert world position back to texture position:
+	endPosition = endPosition / volScale;
+	return endPosition;
+}
+
+float distance2Plane(in vec4 samplePos, in vec4 clipPlane) {
+	// treat clipPlane.a > 1 as "no clip" sentinel (keeps existing behavior)
+	if (clipPlane.a > 1.0) {
+			return 1000.0; // sentinel large distance
+	}
+	vec3 n = clipPlane.xyz;
+	const float EPS = 1e-6;
+	float nlen = length(n);
+	if (nlen < EPS) {
+			return 1000.0; // invalid plane normal
+	}
+	// signed plane value: dot(n, p-0.5) + a
+	float signedDist = dot(n, samplePos.xyz - 0.5) + clipPlane.a;
+	// perpendicular (Euclidean) distance is |signedDist| / |n|
+	return abs(signedDist) / nlen;
+}
+
+// see if clip plane trims ray sampling range sampleStartEnd.x..y
+void clipSampleRange(in vec3 dir, in vec4 rayStart, in vec4 clipPlane, inout vec2 sampleStartEnd, inout bool hasClip) {
+	const float CSR_EPS = 1e-6;
+	// quick exit: no clip plane
+	if (clipPlane.a > 1.0)
+			return;
+	hasClip = true;
+	// quick exit: empty range
+	if ((sampleStartEnd.y - sampleStartEnd.x) <= CSR_EPS)
+			return;
+	// Which side does the ray start on? (plane eqn: dot(n, p-0.5) + a = 0)
+	float sampleSide = dot(clipPlane.xyz, rayStart.xyz - 0.5) + clipPlane.a;
+	bool startsFront = (sampleSide < 0.0);
+	float dis = - 1.0;
+	// plane normal dot ray direction
+	float cdot = dot(dir, clipPlane.xyz);
+	// avoid division by 0 for near-parallel plne
+	if (abs(cdot) >= CSR_EPS)
+		dis = (-clipPlane.a - dot(clipPlane.xyz, rayStart.xyz - 0.5)) / cdot;
+	if (dis < 0.0 || dis > sampleStartEnd.y + CSR_EPS) {
+			if (startsFront)
+				sampleStartEnd = vec2(0.0, 0.0);
+			return;
+	}
+	bool frontface = (cdot > 0.0);
+	if (frontface)
+		sampleStartEnd.x = max(sampleStartEnd.x, dis);
+	else
+		sampleStartEnd.y = min(sampleStartEnd.y, dis);
+	// if nothing remains, mark empty
+	if (sampleStartEnd.y - sampleStartEnd.x <= CSR_EPS)
+		sampleStartEnd = vec2(0.0, 0.0);
+}
+
+bool skipSample (float pos, vec2 sampleRange) {
+	return (pos < sampleRange.x || pos > sampleRange.y);
+}
+
+float frac2ndc(vec3 frac) {
+//https://stackoverflow.com/questions/7777913/how-to-render-depth-linearly-in-modern-opengl-with-gl-fragcoord-z-in-fragment-sh
+	vec4 pos = vec4(frac.xyz, 1.0); //fraction
+	vec4 dim = vec4(vec3(textureSize(volume, 0)), 1.0);
+	pos = pos * dim;
+	vec4 shim = vec4(-0.5, -0.5, -0.5, 0.0);
+	pos += shim;
+	vec4 mm = transpose(matRAS) * pos;
+	float z_ndc = (mvpMtx * vec4(mm.xyz, 1.0)).z;
+	return (z_ndc + 1.0) / 2.0;
+}`+Rr,Vr=`void main() {
+	if (fColor.x > 2.0) {
+		fColor = vec4(1.0, 0.0, 0.0, 0.5);
+		return;
+	}
+	fColor = vec4(0.0,0.0,0.0,0.0);
+	vec4 clipPlaneColorX = clipPlaneColor;
+	//if (clipPlaneColor.a < 0.0)
+	//	clipPlaneColorX.a = - 1.0;
+	bool isColorPlaneInVolume = false;
+	if (clipPlaneColorX.a < 0.0) {
+		isColorPlaneInVolume = true;
+		clipPlaneColorX.a = 0.0;
+	}
+	//fColor = vec4(vColor.rgb, 1.0); return;
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	vec3 backPosition = GetBackPosition(start);
+	// fColor = vec4(backPosition, 1.0); return;
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	dir = normalize(dir);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) { //length limit for parallel rays
+		return;
+	}
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	vec4 deltaDir = vec4(dir.xyz * stepSize, stepSize);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+
+	vec2 sampleRange = vec2(0.0, len);
+	bool hasClip = false;
+	for (int i = 0; i < MAX_CLIP_PLANES; i++)
+		clipSampleRange(dir, samplePos, clipPlanes[i], sampleRange, hasClip);
+	bool isClip = (sampleRange.x > 0.0) || ((sampleRange.y < len) && (sampleRange.y > 0.0));
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	if ((isClipCutaway) && (sampleRange.x <= 0.0) && (sampleRange.y >= len)) {
+		//completely clipped, but ray does not intersect plane
+		if (hasClip)
+			samplePos.a = len + 1.0;
+		else
+			sampleRange = vec2(0.0, 0.0);
+	}
+	if ((!isClipCutaway) && (sampleRange.x >= sampleRange.y))
+		samplePos.a = len + 1.0;
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		float val = texture(volume, samplePos.xyz).a;
+		if (val > 0.01)
+			break;
+		samplePos += deltaDirFast; //advance ray position
+	}
+	float drawOpacityA = renderDrawAmbientOcclusionXY.y;
+	if ((samplePos.a >= len) && (((overlays < 1.0) && (drawOpacityA <= 0.0) ) || (backgroundMasksOverlays > 0)))  {
+		if (isClip)
+			fColor += clipPlaneColorX;
+		return;
+	}
+	fColor = vec4(1.0, 1.0, 1.0, 1.0);
+	//gl_FragDepth = frac2ndc(samplePos.xyz); //crude due to fast pass resolution
+	if (samplePos.a > deltaDirFast.a )
+		samplePos -= deltaDirFast;
+	//end: fast pass
+	vec4 colAcc = vec4(0.0,0.0,0.0,0.0);
+	vec4 firstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	const float earlyTermination = 0.95;
+	float backNearest = len; //assume no hit
+	float ran = fract(sin(gl_FragCoord.x * 12.9898 + gl_FragCoord.y * 78.233) * 43758.5453);
+	// clip planes create steep gradients: reduce aliasing with more jitter
+	if (isClip)
+		samplePos += deltaDir * ran * 1.41; //jitter ray
+	else
+		samplePos += deltaDir * ran; //jitter ray
+	vec2 overlaySampleRange = isClipAllVolumes ? sampleRange : vec2(0.0, len);
+	bool overlayIsClipCutaway = isClipAllVolumes && isClipCutaway;
+`,yi=`
+	if (firstHit.a < len) {
+		gl_FragDepth = frac2ndc(firstHit.xyz);
+		vec4 paqdSample = texture(paqd, samplePos.xyz);
+		if (paqdSample.a > 0.0) {
+			//colAcc.rgb = paqdSample.rgb;
+			float a = max(abs(paqdUniforms[2]), abs(paqdUniforms[3]));
+			colAcc.rgb = mix(colAcc.rgb, paqdSample.rgb, 0.5 * paqdSample.a * a);
+		}
+		if (isClip) {
+			//shade voxels with clip color
+			if (clipPlaneColor.a < 0.0) {
+					float thresh = 4.0 * sliceSize;
+					float firstHit1 = firstHit.a + deltaDir.a;
+				if (isClipCutaway) {
+					float min1 = abs(firstHit1 - sampleRange.y);
+					float dx = samplePos.a - firstHit1;
+					if (min1 < thresh)
+						colAcc.rgb = mix(colAcc.rgb, clipPlaneColorX.rgb, abs(clipPlaneColor.a));
+					else if (( colAcc.a > earlyTermination ) && (dx > thresh)) {
+						min1 = abs(firstHit1 - sampleRange.x);
+						if (min1 < (thresh * 0.5)) {
+							colAcc.rgb = mix(colAcc.rgb , clipPlaneColorX.rgb, abs(clipPlaneColor.a)*0.5);
+						}
+							
+					}
+				} else {
+					if (abs(firstHit1 - sampleRange.x) < thresh)
+						colAcc.rgb = mix(colAcc.rgb, clipPlaneColorX.rgb, abs(clipPlaneColor.a));
+				} // clipPlaneColor.a < 0.0
+			}
+			//ambient occlusion: make creases dark
+			float min1 = 1000.0;
+			float min2 = 1000.0;
+			// find smallest and second-smallest distances
+			vec4 firstHit1 = firstHit - deltaDir;
+			for (int i = 0; i < MAX_CLIP_PLANES; i++) {
+				float d = distance2Plane(firstHit1, clipPlanes[i]);
+				if (d < min1) {
+						min2 = min1;
+						min1 = d;
+				} else if (d < min2) {
+						min2 = d;
+				}
+			}
+			float thresh = 1.2 * sliceSize;
+			if ((isClipCutaway) && (min2 < thresh) && (sampleRange.x > 0.0)) {
+				if ((abs(sampleRange.x - firstHit.a) > ( 2.0 * thresh)) && ((abs(sampleRange.y - firstHit.a) > (2.0 * thresh))))
+					min2 = thresh; 
+			}
+			// if second is 0 -> factor 0 (black), if second >= sliceSize -> factor 1 (unchanged)
+			const float aoFrac = 0.5;
+			float factor = (1.0 - aoFrac) + aoFrac * clamp(min2 / thresh, 0.0, 1.0);
+			// linear darkening: multiply color by factor (or use mix(vec3(0), colAcc.rgb, factor))
+			colAcc.rgb *= factor;
+		}
+	}
+	colAcc.a = (colAcc.a / earlyTermination) * backOpacity;
+	fColor = colAcc;
+	float renderDrawAmbientOcclusionX = renderDrawAmbientOcclusionXY.x;
+	float drawOpacity = renderDrawAmbientOcclusionXY.y;
+	if ((overlays < 1.0) && (drawOpacity <= 0.0))
+		return;
+	//overlay pass
+	samplePos = vec4(start.xyz, 0.0); //ray position
+	//start: OPTIONAL fast pass: rapid traversal until first hit
+	stepSizeFast = sliceSize * 1.0;
+	deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, overlaySampleRange) ^^ overlayIsClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		float val = texture(overlay, samplePos.xyz).a;
+		if (drawOpacity > 0.0) {
+			if (smoothDrawing > 0.0) {
+				if (!isClipAllVolumes || !(skipSample(samplePos.a, sampleRange) ^^ isClipCutaway))
+					val = max(val, texture(drawSmoothed, samplePos.xyz).r * 2.0);
+			} else
+				val = max(val, texture(drawing, samplePos.xyz).r);
+		}
+		if (val > 0.001)
+			break;
+		samplePos += deltaDirFast; //advance ray position
+	}
+	if (samplePos.a >= len) {
+		if (isClip && (fColor.a == 0.0))
+				fColor += clipPlaneColorX;
+			return;
+	}
+	samplePos -= deltaDirFast;
+	if (samplePos.a < 0.0)
+		vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	//end: fast pass
+	float overFarthest = len;
+	colAcc = vec4(0.0, 0.0, 0.0, 0.0);
+
+	samplePos += deltaDir * ran; //jitter ray
+	vec4 overFirstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	if (backgroundMasksOverlays > 0)
+		samplePos = firstHit;
+	bool firstDraw = true;
+	// Hoist per-ray constants used by the smooth drawing path.
+	vec3 vxSize = 1.0 / vec3(textureSize(drawing, 0));
+	vec3 nRayDir = normalize(rayDir);
+	// For smooth drawing with a clip plane: if the ray enters the unclipped region
+	// already inside the drawn volume, start with prevSmoothOut=false so no
+	// outside→inside transition is detected, suppressing the clip-plane cap face.
+	bool prevSmoothOut = true;
+	bool enteredFromOutside = false;
+	vec4 cachedSmoothColor = vec4(0.0);
+	if (isClipAllVolumes && isClip && !isClipCutaway && smoothDrawing > 0.0) {
+		vec3 clipEntry = start.xyz + dir * sampleRange.x;
+		if (texture(drawSmoothed, clipEntry).r >= 0.5)
+			prevSmoothOut = false;
+	}
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, overlaySampleRange) ^^ overlayIsClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		vec4 colorSample = texture(overlay, samplePos.xyz);
+		if ((colorSample.a < 0.01) && (drawOpacity > 0.0)) {
+			if (smoothDrawing > 0.0) {
+				// Smooth drawing: isosurface rendering with gradient-based shading
+				// Clip the smooth surface only when isClipAllVolumes is set
+				if (isClipAllVolumes && (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway)) {
+					samplePos += deltaDir;
+					continue;
+				}
+				float smoothVal = texture(drawSmoothed, samplePos.xyz).r;
+				bool nowSmoothInside = (smoothVal > 0.5);
+				// Track entry transitions: only mark enteredFromOutside on a genuine
+				// outside→inside crossing; clear it when we exit.
+				if (!nowSmoothInside) {
+					prevSmoothOut = true;
+					enteredFromOutside = false;
+				} else if (prevSmoothOut) {
+					// First inside sample: compute gradient, pen color, and Phong shading
+					// once and cache the result for all subsequent interior steps.
+					prevSmoothOut = false;
+					enteredFromOutside = true;
+					float gx = texture(drawSmoothed, samplePos.xyz + vec3(vxSize.x, 0.0, 0.0)).r
+					         - texture(drawSmoothed, samplePos.xyz - vec3(vxSize.x, 0.0, 0.0)).r;
+					float gy = texture(drawSmoothed, samplePos.xyz + vec3(0.0, vxSize.y, 0.0)).r
+					         - texture(drawSmoothed, samplePos.xyz - vec3(0.0, vxSize.y, 0.0)).r;
+					float gz = texture(drawSmoothed, samplePos.xyz + vec3(0.0, 0.0, vxSize.z)).r
+					         - texture(drawSmoothed, samplePos.xyz - vec3(0.0, 0.0, vxSize.z)).r;
+					vec3 grad = vec3(gx, gy, gz);
+					float gradLen = length(grad);
+					vec3 normal = gradLen > 0.001 ? normalize(grad) : vec3(0.0, 0.0, 1.0);
+					// Get pen color from original drawing texture.
+					float drawVal = texture(drawing, samplePos.xyz).r;
+					if (drawVal == 0.0) {
+						// Between painted voxels: step inward along the gradient
+						// to find the nearest painted voxel's pen color.
+						// (normal points inward toward higher smooth values)
+						for (int k = 1; k <= 8; k++) {
+							drawVal = texture(drawing, samplePos.xyz + normal * vxSize * float(k)).r;
+							if (drawVal > 0.0) break;
+						}
+					}
+					vec4 draw = drawColor(max(drawVal, 1.0 / 255.0), drawOpacity);
+					// Phong shading with two-sided lighting.
+					float NdotL = abs(dot(normal, nRayDir));
+					vec3 reflected = reflect(nRayDir, normal);
+					float spec = pow(max(dot(reflected, -nRayDir), 0.0), 20.0);
+					draw.rgb *= (0.4 + 0.6 * NdotL);
+					draw.rgb += vec3(0.2 * spec);
+					cachedSmoothColor = draw;
+				}
+				// Use the cached shaded color for every interior step.
+				if (nowSmoothInside && enteredFromOutside) {
+					colorSample = cachedSmoothColor;
+				}
+			} else {
+				// Original discrete drawing path
+				float val = texture(drawing, samplePos.xyz).r;
+				vec4 draw = drawColor(val, drawOpacity);
+				if ((draw.a > 0.0) && (firstDraw)) {
+				firstDraw = false;
+				float sum = 0.0;
+				const float mn = 1.0 / 256.0;
+				const float sampleRadius = 1.1;
+				float dx = sliceSize * sampleRadius;
+				vec3 center = samplePos.xyz;
+				//six neighbors that share a face
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,0.0), dir)).r, mn);
+				//float proportion = (sum / mn) / 6.0;
+				
+				//12 neighbors that share an edge
+				dx = sliceSize * sampleRadius * sqrt(2.0) * 0.5;
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,+dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,-dx,0.0), dir)).r, mn);
+
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,-dx,0.0), dir)).r, mn);
+				
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,+dx,0.0), dir)).r, mn);
+				float proportion = (sum / mn) / 18.0; //proportion of six neighbors is non-zero
+				
+				//a high proportion of hits means crevice
+				//since the AO term adds shadows that darken most voxels, it will result in dark surfaces
+				//the term brighten adds a little illumination to balance this
+				// without brighten, only the most extreme ridges will not be darker
+				const float brighten = 1.2;
+				vec3 ao = draw.rgb * (1.0 - proportion) * brighten;
+				draw.rgb = mix (draw.rgb, ao , renderDrawAmbientOcclusionX);
+			}
+			colorSample = draw;
+			} // end else (discrete drawing path)
+		}
+		samplePos += deltaDir; //advance ray position
+		if (colorSample.a >= 0.01) {
+			if (overFirstHit.a > len)
+				overFirstHit = samplePos;
+			colorSample.a *= renderOverlayBlend;
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			overFarthest = samplePos.a;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+	}
+	//if (samplePos.a >= len) {
+	if (colAcc.a <= 0.0) {
+		if (isClip && (fColor.a == 0.0))
+			fColor += clipPlaneColorX;
+		return;
+	}
+	if (overFirstHit.a < firstHit.a)
+		gl_FragDepth = frac2ndc(overFirstHit.xyz);
+	float overMix = colAcc.a;
+	float overlayDepth = 0.3;
+	if (fColor.a <= 0.0)
+		overMix = 1.0;
+	else if (((overFarthest) > backNearest)) {
+		float dx = (overFarthest - backNearest)/1.73;
+		dx = fColor.a * pow(dx, overlayDepth);
+		overMix *= 1.0 - dx;
+	}
+	fColor.rgb = mix(fColor.rgb, colAcc.rgb, overMix);
+	fColor.a = max(fColor.a, colAcc.a);
+}`,N0=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler3D drawSmoothed;
+uniform float smoothDrawing;
+uniform highp sampler2D colormap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+uniform bool isClipAllVolumes;
+in vec3 vColor;
+out vec4 fColor;
+`+zt+`
+	void main() {
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	vec3 backPosition = GetBackPosition(start);
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) { //length limit for parallel rays
+		fColor = vec4(0.0,0.0,0.0,0.0);
+		return;
+	}
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	vec4 deltaDir = vec4(dir.xyz * stepSize, stepSize);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	vec4 colAcc = vec4(0.0,0.0,0.0,0.0);
+	vec4 firstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	const float earlyTermination = 0.95;
+	float backNearest = len; //assume no hit
+	float dis = len;
+	//check if axial plane is closest
+	vec4 aClip = vec4(0.0, 0.0, 1.0, (1.0- clipPlane.z) - 0.5);
+	float adis = (-aClip.a - dot(aClip.xyz, samplePos.xyz-0.5)) / dot(dir,aClip.xyz);
+	if (adis > 0.0)
+		dis = min(adis, dis);
+	//check of coronal plane is closest
+	vec4 cClip = vec4(0.0, 1.0, 0.0, (1.0- clipPlane.y) - 0.5);
+	float cdis = (-cClip.a - dot(cClip.xyz, samplePos.xyz-0.5)) / dot(dir,cClip.xyz);
+	if (cdis > 0.0)
+		dis = min(cdis, dis);
+	//check if coronal slice is closest
+	vec4 sClip = vec4(1.0, 0.0, 0.0, (1.0- clipPlane.x) - 0.5);
+	float sdis = (-sClip.a - dot(sClip.xyz, samplePos.xyz-0.5)) / dot(dir,sClip.xyz);
+	if (sdis > 0.0)
+		dis = min(sdis, dis);
+	if ((dis > 0.0) && (dis < len)) {
+		samplePos = vec4(samplePos.xyz+dir * dis, dis);
+		colAcc = texture(volume, samplePos.xyz);
+		colAcc.a = earlyTermination;
+		firstHit = samplePos;
+		backNearest = min(backNearest, samplePos.a);
+	}
+	//the following are only used by overlays
+	vec4 clipPlaneColorX = clipPlaneColor;
+	bool isColorPlaneInVolume = false;
+	bool isClip = false;
+	bool isClipCutaway = false;
+	vec2 sampleRange = vec2(0.0, len);
+	// vec4 clipPos = applyClip(dir, samplePos, len, isClip);
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	vec2 overlaySampleRange = vec2(0.0, len);
+	bool overlayIsClipCutaway = false;
+	if (samplePos.a < 0.0)
+		vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	float ran = fract(sin(gl_FragCoord.x * 12.9898 + gl_FragCoord.y * 78.233) * 43758.5453);
+	samplePos += deltaDir * ran; //jitter ray
+`+yi,L0=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler3D drawSmoothed;
+uniform float smoothDrawing;
+uniform highp sampler2D colormap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+uniform bool isClipAllVolumes;
+in vec3 vColor;
+out vec4 fColor;
+`+zt+Vr+`while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		samplePos += deltaDir; //advance ray position
+		if (colorSample.a >= 0.01) {
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			// backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+	}
+	if (firstHit.a < len)
+		backNearest = firstHit.a;
+`+yi,Bt=192,Gn=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 normMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing, gradient;
+uniform highp sampler3D drawSmoothed;
+uniform float smoothDrawing;
+uniform highp sampler2D colormap;
+uniform highp sampler2D matCap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+uniform float gradientAmount;
+uniform float silhouettePower;
+uniform float gradientOpacity[${Bt}];
+uniform bool isClipAllVolumes;
+in vec3 vColor;
+out vec4 fColor;
+`,k0=Gn+zt+Vr+`
+	float startPos = samplePos.a;
+	float clipCloseThresh = 5.0 * deltaDir.a;
+	float clipClose = sampleRange.x;
+	if (isClipCutaway)
+		clipClose = sampleRange.y;
+	if (!isClip)
+		clipClose = -1.0;
+	float brighten = 2.0; //modulating makes average intensity darker 0.5 * 0.5 = 0.25
+	//vec4 prevGrad = vec4(0.0);
+	float silhouetteThreshold = 1.0 - silhouettePower;
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		if (colorSample.a >= 0.0) {
+			vec4 grad = texture(gradient, samplePos.xyz);
+			grad.rgb = grad.rgb*2.0 - 1.0;
+			if (grad.a > 0.0)
+				grad.rgb = normalize(grad.rgb);
+			//if (grad.a < prevGrad.a)
+			//	grad.rgb = prevGrad.rgb;
+			//prevGrad = grad;
+			vec3 n = mat3(normMtx) * grad.rgb;
+			n.y = - n.y;
+			vec4 mc = vec4(texture(matCap, n.xy * 0.5 + 0.5).rgb, 1.0) * brighten;
+			mc = mix(vec4(1.0), mc, gradientAmount);
+			if (abs(samplePos.a - clipClose) > clipCloseThresh)
+				colorSample.rgb *= mc.rgb;
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			int gradIdx = int(grad.a * ${Bt}.0);
+			colorSample.a *= gradientOpacity[gradIdx];
+			float lightNormDot = dot(grad.rgb, rayDir);
+			// n.b. "lightNormDor" is cosTheta, "silhouettePower" is Fresnel effect exponent
+ 			colorSample.a *= pow(1.0 - abs(lightNormDot), silhouettePower);
+ 			float viewAlign = abs(lightNormDot); // 0 = perpendicular, 1 = aligned
+ 			// linearly map silhouettePower (0..1) to a threshold range, e.g., [1.0, 0.0]
+ 			// Cull voxels that are too aligned with the view direction
+ 			if (viewAlign > silhouetteThreshold)
+ 				colorSample.a = 0.0;
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+		samplePos += deltaDir; //advance ray position
+	}
+`+yi,O0=Gn+zt+Vr+`
+	float startPos = samplePos.a;
+	//float clipClose = clipPos.a + 3.0 * deltaDir.a; //do not apply gradients near clip plane
+	float brighten = 2.0; //modulating makes average intensity darker 0.5 * 0.5 = 0.25
+	//vec4 prevGrad = vec4(0.0);
+	while (samplePos.a <= len) {
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		if (colorSample.a >= 0.0) {
+			vec4 grad = texture(gradient, samplePos.xyz);
+			grad.rgb = grad.rgb*2.0 - 1.0;
+			if (grad.a > 0.0)
+				grad.rgb = normalize(grad.rgb);
+			colorSample.rgb = abs(grad.rgb);
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+		samplePos += deltaDir; //advance ray position
+	}
+`+yi,li=`#version 300 es
+#line 392
+layout(location=0) in vec3 pos;
+uniform int axCorSag;
+uniform mat4 mvpMtx;
+uniform mat4 frac2mm;
+uniform float slice;
+out vec3 texPos;
+void main(void) {
+	texPos = vec3(pos.x, pos.y, slice);
+	if (axCorSag > 1)
+		texPos = vec3(slice, pos.x, pos.y);
+	else if (axCorSag > 0)
+		texPos = vec3(pos.x, slice, pos.y);
+	vec4 mm = frac2mm * vec4(texPos, 1.0);
+	gl_Position = mvpMtx * mm;
+}`,Yn=`#version 300 es
+#line 411
+precision highp int;
+precision highp float;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform int backgroundMasksOverlays;
+uniform float overlayOutlineWidth;
+uniform float overlayAlphaShader;
+uniform int axCorSag;
+uniform float overlays;
+uniform float opacity;
+uniform float drawOpacity;
+uniform float drawRimOpacity;
+uniform bool isAlphaClipDark;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+in vec3 texPos;
+out vec4 color;
+`+Rr+`
+vec4 blendRGBA(vec4 foreground, vec4 background) {
+  float alphaOut = foreground.a + background.a * (1.0 - foreground.a);
+  vec3 colorOut = (foreground.rgb * foreground.a + background.rgb * background.a * (1.0 - foreground.a)) / alphaOut;
+  return vec4(colorOut, alphaOut);
+}
+float paqdEaseAlpha(float alpha) {
+  // t are alpha transitions
+  // <t0 -> y0
+  // t0..t1  -> mix between y0..y1
+  // t1..t2 -> mix between y1..y2
+  // >t2 -> y2
+  float t0 = paqdUniforms[0]; // 0.3;
+  float t1 = 0.5 * (paqdUniforms[0] + paqdUniforms[1]); // 0.4;
+  float t2 = paqdUniforms[1]; // 0.9;
+  float y0 = 0.0;
+  float y1 = abs(paqdUniforms[2]); // 1.0;
+  float y2 = abs(paqdUniforms[3]); //0.25;
+  if (alpha <= t0) {
+    return y0;
+  } else if (alpha <= t1) {
+    return mix(y0, y1, (alpha - t0) / (t1 - t0)); // LERP 0.0 → 1.0
+  } else if (alpha <= t2) {
+    return mix(y1, y2, (alpha - t1) / (t2 - t1)); // LERP 1.0 → 0.2
+  } else {
+    return y2;
+  }
+}
+
+void main() {
+	//color = vec4(1.0, 0.0, 1.0, 1.0);return;
+	vec4 background = texture(volume, texPos);
+	color = vec4(background.rgb, opacity);
+	if ((isAlphaClipDark) && (background.a == 0.0)) color.a = 0.0; //FSLeyes clipping range
+	vec4 ocolor = vec4(0.0);
+	float overlayAlpha = overlayAlphaShader;
+	if (overlays > 0.0) {
+		ocolor = texture(overlay, texPos);
+		//dFdx for "boxing" issue 435 has aliasing on some implementations (coarse vs fine)
+		//however, this only identifies 50% of the edges due to aliasing effects
+		// http://www.aclockworkberry.com/shader-derivative-functions/
+		// https://bgolus.medium.com/distinctive-derivative-differences-cce38d36797b
+		//if ((ocolor.a >= 1.0) && ((dFdx(ocolor.a) != 0.0) || (dFdy(ocolor.a) != 0.0)  ))
+		//	ocolor.rbg = vec3(0.0, 0.0, 0.0);
+		bool isOutlineBelowNotAboveThreshold = true;
+		if (isOutlineBelowNotAboveThreshold) {
+			if ((overlayOutlineWidth > 0.0) && (ocolor.a < 1.0)) { //check voxel neighbors for edge
+				vec3 vx = (overlayOutlineWidth ) / vec3(textureSize(overlay, 0));
+				//6 voxel neighbors that share a face
+				vec3 vxR = vec3(texPos.x+vx.x, texPos.y, texPos.z);
+				vec3 vxL = vec3(texPos.x-vx.x, texPos.y, texPos.z);
+				vec3 vxA = vec3(texPos.x, texPos.y+vx.y, texPos.z);
+				vec3 vxP = vec3(texPos.x, texPos.y-vx.y, texPos.z);
+				vec3 vxS = vec3(texPos.x, texPos.y, texPos.z+vx.z);
+				vec3 vxI = vec3(texPos.x, texPos.y, texPos.z-vx.z);
+				float a = 0.0;
+				if (axCorSag != 2) {
+					a = max(a, texture(overlay, vxR).a);
+					a = max(a, texture(overlay, vxL).a);
+				}
+				if (axCorSag != 1) {
+					a = max(a, texture(overlay, vxA).a);
+					a = max(a, texture(overlay, vxP).a);
+				}
+				if (axCorSag != 0) {
+					a = max(a, texture(overlay, vxS).a);
+					a = max(a, texture(overlay, vxI).a);
+				}
+				bool isCheckCorners = true;
+				if (isCheckCorners) {
+					//12 voxel neighbors that share an edge
+					vec3 vxRA = vec3(texPos.x+vx.x, texPos.y+vx.y, texPos.z);
+					vec3 vxLA = vec3(texPos.x-vx.x, texPos.y+vx.y, texPos.z);
+					vec3 vxRP = vec3(texPos.x+vx.x, texPos.y-vx.y, texPos.z);
+					vec3 vxLP = vec3(texPos.x-vx.x, texPos.y-vx.y, texPos.z);
+					vec3 vxRS = vec3(texPos.x+vx.x, texPos.y, texPos.z+vx.z);
+					vec3 vxLS = vec3(texPos.x-vx.x, texPos.y, texPos.z+vx.z);
+					vec3 vxRI = vec3(texPos.x+vx.x, texPos.y, texPos.z-vx.z);
+					vec3 vxLI = vec3(texPos.x-vx.x, texPos.y, texPos.z-vx.z);
+					vec3 vxAS = vec3(texPos.x, texPos.y+vx.y, texPos.z+vx.z);
+					vec3 vxPS = vec3(texPos.x, texPos.y-vx.y, texPos.z+vx.z);
+					vec3 vxAI = vec3(texPos.x, texPos.y+vx.y, texPos.z-vx.z);
+					vec3 vxPI = vec3(texPos.x, texPos.y-vx.y, texPos.z-vx.z);
+
+					if (axCorSag == 0) { //axial corners
+						a = max(a, texture(overlay, vxRA).a);
+						a = max(a, texture(overlay, vxLA).a);
+						a = max(a, texture(overlay, vxRP).a);
+						a = max(a, texture(overlay, vxLP).a);
+					}
+					if (axCorSag == 1) { //coronal corners
+						a = max(a, texture(overlay, vxRS).a);
+						a = max(a, texture(overlay, vxLS).a);
+						a = max(a, texture(overlay, vxRI).a);
+						a = max(a, texture(overlay, vxLI).a);
+					}
+					if (axCorSag == 2) { //sagittal corners
+						a = max(a, texture(overlay, vxAS).a);
+						a = max(a, texture(overlay, vxPS).a);
+						a = max(a, texture(overlay, vxAI).a);
+						a = max(a, texture(overlay, vxPI).a);
+					}
+				}
+				if (a >= 1.0) {
+					ocolor = vec4(0.0, 0.0, 0.0, 1.0);
+					overlayAlpha = 1.0;
+				}
+			}
+
+		} else {
+			if ((overlayOutlineWidth > 0.0) && (ocolor.a >= 1.0)) { //check voxel neighbors for edge
+				vec3 vx = (overlayOutlineWidth ) / vec3(textureSize(overlay, 0));
+				vec3 vxR = vec3(texPos.x+vx.x, texPos.y, texPos.z);
+				vec3 vxL = vec3(texPos.x-vx.x, texPos.y, texPos.z);
+				vec3 vxA = vec3(texPos.x, texPos.y+vx.y, texPos.z);
+				vec3 vxP = vec3(texPos.x, texPos.y-vx.y, texPos.z);
+				vec3 vxS = vec3(texPos.x, texPos.y, texPos.z+vx.z);
+				vec3 vxI = vec3(texPos.x, texPos.y, texPos.z-vx.z);
+				float a = 1.0;
+				if (axCorSag != 2) {
+					a = min(a, texture(overlay, vxR).a);
+					a = min(a, texture(overlay, vxL).a);
+				}
+				if (axCorSag != 1) {
+					a = min(a, texture(overlay, vxA).a);
+					a = min(a, texture(overlay, vxP).a);
+				}
+				if (axCorSag != 0) {
+					a = min(a, texture(overlay, vxS).a);
+					a = min(a, texture(overlay, vxI).a);
+				}
+				if (a < 1.0) {
+					ocolor = vec4(0.0, 0.0, 0.0, 1.0);
+					overlayAlpha = 1.0;
+				}
+			}
+		} //outline above threshold
+	}
+
+`,z0=`#version 300 es
+#line 411
+precision highp int;
+precision highp float;
+uniform highp sampler2D volume, overlay;
+uniform int backgroundMasksOverlays;
+uniform float overlayOutlineWidth;
+uniform float overlayAlphaShader;
+uniform int axCorSag;
+uniform float overlays;
+uniform float opacity;
+uniform float drawOpacity;
+uniform bool isAlphaClipDark;
+uniform highp sampler2D drawing;
+uniform highp sampler2D colormap;
+in vec3 texPos;
+out vec4 color;`+Rr+`void main() {
+	//color = vec4(1.0, 0.0, 1.0, 1.0);return;
+	vec4 background = texture(volume, texPos.xy);
+	color = vec4(background.rgb, opacity);
+	if ((isAlphaClipDark) && (background.a == 0.0)) color.a = 0.0; //FSLeyes clipping range
+	vec4 dcolor = drawColor(texture(drawing, texPos.xy).r, drawOpacity);
+	if (dcolor.a > 0.0) {
+		color.rgb = mix(color.rgb, dcolor.rgb, dcolor.a);
+		color.a = max(drawOpacity, color.a);
+	}
+}`,Xn=`	ocolor.a *= overlayAlpha;
+	float drawV = texture(drawing, texPos).r;
+	vec4 dcolor = drawColor(drawV, drawOpacity);
+	if (dcolor.a > 0.0) {
+		if (drawRimOpacity >= 0.0) {
+			vec3 vx = 1.0 / vec3(textureSize(drawing, 0));
+			//6 voxel neighbors that share a face
+			vec3 offsetX = dFdx(texPos); // left-right spacing
+			vec3 offsetY = dFdy(texPos); // up-down spacing
+			float L = texture(drawing, texPos - offsetX).r;
+			float R = texture(drawing, texPos + offsetX).r;
+			float T = texture(drawing, texPos - offsetY).r;
+			float B = texture(drawing, texPos + offsetY).r;
+			if (L != drawV || R != drawV || T != drawV || B != drawV)
+				dcolor.a = drawRimOpacity;
+		}
+		color.rgb = mix(color.rgb, dcolor.rgb, dcolor.a);
+		color.a = max(drawOpacity, color.a);
+	}
+	vec4 pcolor = texture(paqd, texPos);
+	if (pcolor.a > 0.0) {
+		pcolor.a = paqdEaseAlpha(pcolor.a);
+		if (pcolor.a > 0.0) {
+			if (paqdUniforms[3] < 0.0)
+				ocolor = blendRGBA(pcolor, ocolor);
+			else
+				ocolor = blendRGBA(ocolor, pcolor);
+		}
+	}
+	if ((backgroundMasksOverlays > 0) && (background.a == 0.0))
+		return;
+	float a = color.a + ocolor.a * (1.0 - color.a); // premultiplied alpha
+	if (a == 0.0) return;
+	color.rgb = mix(color.rgb, ocolor.rgb, ocolor.a / a);
+	color.a = a;
+}`,G0=Yn+Xn,Y0=Yn+`	if (ocolor.a > 0.0) {
+		//https://gamedev.stackexchange.com/questions/102889/is-it-possible-to-convert-vec4-to-int-in-glsl-using-opengl-es
+		uint alpha = uint(ocolor.a * 255.0);
+		vec3 xyzFlip = vec3(float((uint(1) & alpha) > uint(0)), float((uint(2) & alpha) > uint(0)), float((uint(4) & alpha) > uint(0)));
+		//convert from 0 and 1 to -1 and 1
+		xyzFlip = (xyzFlip * 2.0) - 1.0;
+		//https://math.stackexchange.com/questions/1905533/find-perpendicular-distance-from-point-to-line-in-3d
+		//v1 principle direction of tensor for this voxel
+		vec3 v1 = ocolor.rgb;
+		//flips encode polarity to convert from 0..1 to -1..1 (27 bits vs 24 bit precision)
+		v1 = normalize( v1 * xyzFlip);
+		vec3 vxl = fract(texPos * vec3(textureSize(volume, 0))) - 0.5;
+		//vxl coordinates now -0.5..+0.5 so 0,0,0 is origin
+		vxl.x = -vxl.x;
+		float t = dot(vxl,v1);
+		vec3 P = t * v1;
+		float dx = length(P-vxl);
+		ocolor.a = 1.0 - smoothstep(0.2,0.25, dx);
+		//if modulation was applied, use that to scale alpha not color:
+		ocolor.a *= length(ocolor.rgb);
+		ocolor.rgb = normalize(ocolor.rgb);
+		//compute distance one half voxel closer to viewer:
+		float pan = 0.5;
+		if (axCorSag == 0)
+			vxl.z -= pan;
+		if (axCorSag == 1)
+			vxl.y -= pan;
+		if (axCorSag == 2)
+			vxl.x += pan;
+		t = dot(vxl,v1);
+		P = t * v1;
+		float dx2 = length(P-vxl);
+		ocolor.rgb += (dx2-dx-(0.5 * pan)) * 1.0;
+	}
+`+Xn,Ni=`#version 300 es
+#line 480
+precision highp int;
+precision highp float;
+uniform vec4 lineColor;
+out vec4 color;
+void main() {
+	color = lineColor;
+}`,X0=`#version 300 es
+#line 723
+precision highp int;
+precision highp float;
+
+uniform vec4 lineColor;
+uniform vec4 leftTopWidthHeight;
+uniform float thickness; // line thickness in pixels
+uniform vec2 canvasWidthHeight;
+
+out vec4 color;
+
+void main() {
+    // fragment position in screen coordinates
+    vec2 fragCoord = gl_FragCoord.xy;
+
+    // canvas height
+    float canvasHeight = canvasWidthHeight.y;
+
+    // 'top' and 'bottom' to match gl_FragCoord.y coordinate system
+    float top = canvasHeight - leftTopWidthHeight.y;
+    float bottom = top - leftTopWidthHeight.w;
+
+    // left and right edges
+    float left = leftTopWidthHeight.x;
+    float right = left + leftTopWidthHeight.z;
+
+    bool withinLeft = fragCoord.x >= left && fragCoord.x <= left + thickness;
+    bool withinRight = fragCoord.x <= right && fragCoord.x >= right - thickness;
+    bool withinTop = fragCoord.y <= top && fragCoord.y >= top - thickness;
+    bool withinBottom = fragCoord.y >= bottom && fragCoord.y <= bottom + thickness;
+
+    bool isOutline = withinLeft || withinRight || withinTop || withinBottom;
+
+    if (isOutline) {
+        color = lineColor;
+    } else {
+        discard; 
+    }
+}`,W0=`#version 300 es
+#line 490
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+out vec2 vColor;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vColor = pos.xy;
+}`,K0=`#version 300 es
+#line 506
+precision highp int;
+precision highp float;
+uniform highp sampler2D colormap;
+uniform float layer;
+in vec2 vColor;
+out vec4 color;
+void main() {
+	float nlayer = float(textureSize(colormap, 0).y);
+	float fmap = (0.5 + layer) / nlayer;
+	color = vec4(texture(colormap, vec2(vColor.x, fmap)).rgb, 1.0);
+}`,bs=`#version 300 es
+#line 520
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+}`,H0=`#version 300 es
+#line 534
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform float thickness;
+uniform vec4 startXYendXY;
+void main(void) {
+	vec2 posXY = mix(startXYendXY.xy, startXYendXY.zw, pos.x);
+	vec2 dir = normalize(startXYendXY.xy - startXYendXY.zw);
+	posXY += vec2(-dir.y, dir.x) * thickness * (pos.y - 0.5);
+	posXY.x = (posXY.x) / canvasWidthHeight.x; //0..1
+	posXY.y = 1.0 - (posXY.y / canvasWidthHeight.y); //1..0
+	gl_Position = vec4((posXY * 2.0) - 1.0, 0.0, 1.0);
+}`,q0=`#version 300 es
+#line 534
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform float thickness;
+uniform vec2 startXY;
+uniform vec3 endXYZ; // transformed XYZ point
+void main(void) {	
+	vec2 posXY = mix(startXY.xy, endXYZ.xy, pos.x);
+	vec2 startDiff = endXYZ.xy - startXY.xy;
+	float startDistance = length(startDiff);
+	vec2 diff = endXYZ.xy - posXY;
+	float currentDistance = length(diff);
+	vec2 dir = normalize(startXY.xy - endXYZ.xy);
+	posXY += vec2(-dir.y, dir.x) * thickness * (pos.y - 0.5);
+	posXY.x = (posXY.x) / canvasWidthHeight.x; //0..1
+	posXY.y = 1.0 - (posXY.y / canvasWidthHeight.y); //1..0	
+	float z = endXYZ.z * ( 1.0 - abs(currentDistance/startDistance)); 
+	gl_Position = vec4((posXY * 2.0) - 1.0, z, 1.0);
+}`,Q0=`#version 300 es
+#line 549
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = vec2(pos.x, 1.0 - pos.y);
+}`,Z0=`#version 300 es
+#line 565
+precision highp int;
+precision highp float;
+uniform highp sampler2D bmpTexture;
+in vec2 vUV;
+out vec4 color;
+void main() {
+	color = texture(bmpTexture, vUV);
+}`,j0=`#version 300 es
+#line 576
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+uniform vec4 uvLeftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = vec2(uvLeftTopWidthHeight.x + (pos.x * uvLeftTopWidthHeight.z), uvLeftTopWidthHeight.y  + ((1.0 - pos.y) * uvLeftTopWidthHeight.w) );
+}`,_0=`#version 300 es
+#line 593
+precision highp int;
+precision highp float;
+uniform highp sampler2D fontTexture;
+uniform vec4 fontColor;
+uniform float screenPxRange;
+in vec2 vUV;
+out vec4 color;
+float median(float r, float g, float b) {
+	return max(min(r, g), min(max(r, g), b));
+}
+void main() {
+	vec3 msd = texture(fontTexture, vUV).rgb;
+	float sd = median(msd.r, msd.g, msd.b);
+	float screenPxDistance = screenPxRange*(sd - 0.5);
+	float opacity = clamp(screenPxDistance + 0.5, 0.0, 1.0);
+	color = vec4(fontColor.rgb , fontColor.a * opacity);
+}`,J0=`#version 300 es
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+uniform vec4 uvLeftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = pos.xy;
+}`,$0=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 circleColor;
+uniform float fillPercent;
+in vec2 vUV;
+out vec4 color;
+void main() {
+	/* Check if the pixel is inside the circle
+		 and color it with a gradient. Otherwise, color it 
+		 transparent   */
+	float distance = length(vUV-vec2(0.5,0.5));
+	if ( distance < 0.5 && distance >= (1.0 - fillPercent) / 2.0){
+			color = vec4(circleColor.r,circleColor.g,circleColor.b,circleColor.a) ;			
+	}else{
+			color = vec4(0.0,0.0,0.0,0.0);
+	}
+}
+`,Je=`#version 300 es
+#line 613
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	gl_Position = vec4( (vPos.xy-vec2(0.5,0.5)) * 2.0, 0.0, 1.0);
+}`,Ht=`#version 300 es
+uniform highp usampler3D intensityVol;
+`,Cs=`#version 300 es
+uniform highp isampler3D intensityVol;
+`,ed=`#version 300 es
+uniform highp sampler3D intensityVol;
+`,Ms=`#line 1042
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform bool isAdditiveBlend;
+uniform float coordZ;
+uniform float layer;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform uint activeIndex;
+uniform vec4 xyzaFrac;
+uniform mat4 mtx;
+float textureWidth;
+float nlayer;
+float layerY;
+
+vec4 scalar2color(uint idx) {
+	float fx = (float(idx) + 0.5) / textureWidth;
+	vec4 clr = texture(colormap, vec2(fx, layerY)).rgba;
+	if (clr.a > 0.0)
+		clr.a = 1.0;
+	clr.a *= opacity;
+	return clr;
+}
+void main(void) {
+	vec4 vx = vec4(TexCoord.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint idx = uint(texture(intensityVol, vx.xyz).r);
+	if (idx == uint(0)) {
+		if (layer < 1.0) {
+			FragColor = vec4(0.0, 0.0, 0.0, 0.0);
+			return;
+		}
+		FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		return;
+	}
+	textureWidth = float(textureSize(colormap, 0).x);
+	nlayer = float(textureSize(colormap, 0).y);
+	layerY = ((2.0 * layer) + 1.5) / nlayer;
+	//idx = ((idx - uint(1)) % uint(100))+uint(1);
+	FragColor = scalar2color(idx);
+	bool isBorder = false;
+	vx = vec4(TexCoord.x+xyzaFrac.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint R = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x-xyzaFrac.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint L = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y+xyzaFrac.y, coordZ, 1.0) * mtx;
+	uint A = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y-xyzaFrac.y, coordZ, 1.0) * mtx;
+	uint P = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y, coordZ+xyzaFrac.z, 1.0) * mtx;
+	uint S = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y, coordZ-xyzaFrac.z, 1.0) * mtx;
+	uint I = uint(texture(intensityVol, vx.xyz).r);
+	vec4 centerColor = FragColor;
+	FragColor.a += scalar2color(R).a;
+	FragColor.a += scalar2color(L).a;
+	FragColor.a += scalar2color(A).a;
+	FragColor.a += scalar2color(P).a;
+	FragColor.a += scalar2color(S).a;
+	FragColor.a += scalar2color(I).a;
+	FragColor.a /= 7.0;
+	if ((!isBorder) &&(idx == activeIndex)) {
+		if (centerColor.a > 0.5)
+			FragColor.a *= 0.4;
+		else
+			FragColor.a =0.8;
+	}
+	if (xyzaFrac.a != 0.0) { //outline
+		if ((idx != R) || (idx != L) || (idx != A) || (idx != P) || (idx != S) || (idx != I)) {
+			isBorder = true;
+			if (xyzaFrac.a > 0.0)
+				FragColor.a = xyzaFrac.a;
+			else
+				FragColor = vec4(0.0, 0.0, 0.0, 1.0);
+		}
+	}
+	if (layer < 1.0) return;
+		vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		// https://en.wikipedia.org/wiki/Alpha_compositing
+		float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+		if (aout <= 0.0) return;
+		if (isAdditiveBlend)
+			FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a)) / aout;
+		else
+			FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+		FragColor.a = aout;
+}`,Li=`#line 691
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform float cal_maxNeg;
+uniform float cal_minNeg;
+uniform bool isAlphaThreshold;
+uniform bool isColorbarFromZero;
+uniform bool isAdditiveBlend;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+uniform float opacity;
+uniform mat4 mtx;
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	if ((vx.x < 0.0) || (vx.x > 1.0) || (vx.y < 0.0) || (vx.y > 1.0) || (vx.z < 0.0) || (vx.z > 1.0)) {
+		//set transparent if out of range
+		//https://webglfundamentals.org/webgl/webgl-3d-textures-repeat-clamp.html
+		FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		return;
+	}
+	float f = (scl_slope * float(texture(intensityVol, vx.xyz).r)) + scl_inter;
+	float mn = cal_min;
+	float mx = cal_max;
+	if ((isAlphaThreshold) || (isColorbarFromZero))
+		mn = 0.0;
+	float r = max(0.00001, abs(mx - mn));
+	mn = min(mn, mx);
+	float txl = mix(0.0, 1.0, (f - mn) / r);
+	if (f > mn) { //issue1139: survives threshold, so round up to opaque voxel
+		txl = max(txl, 2.0/256.0);
+	}
+	//https://stackoverflow.com/questions/5879403/opengl-texture-coordinates-in-pixel-space
+	float nlayer = float(textureSize(colormap, 0).y);
+	//each volume has two color maps:
+	// (layer*2) = negative and (layer * 2) + 1 = positive
+	float y = ((2.0 * layer) + 1.5)/nlayer;
+	FragColor = texture(colormap, vec2(txl, y)).rgba;
+	//negative colors
+	mn = cal_minNeg;
+	mx = cal_maxNeg;
+	if ((isAlphaThreshold) || (isColorbarFromZero))
+		mx = 0.0;
+	//if ((!isnan(cal_minNeg)) && ( f < mx)) {
+	if ((cal_minNeg < cal_maxNeg) && ( f < mx)) {
+		r = max(0.00001, abs(mx - mn));
+		mn = min(mn, mx);
+		txl = 1.0 - mix(0.0, 1.0, (f - mn) / r);
+		//issue1139: survives threshold, so round up to opaque voxel
+		txl = max(txl, 2.0/256.0);
+		y = ((2.0 * layer) + 0.5)/nlayer;
+		FragColor = texture(colormap, vec2(txl, y));
+	}
+	if (layer > 0.7)
+		FragColor.a = step(0.00001, FragColor.a);
+	//if (modulation > 10)
+	//	FragColor.a *= texture(modulationVol, vx.xyz).r;
+	//	FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	if (isAlphaThreshold) {
+		if ((cal_minNeg != cal_maxNeg) && ( f < 0.0) && (f > cal_maxNeg))
+			FragColor.a = pow(-f / -cal_maxNeg, 2.0);
+		else if ((f > 0.0) && (cal_min > 0.0))
+			FragColor.a *= pow(f / cal_min, 2.0); //issue435:  A = (V/X)**2
+		//FragColor.g = 0.0;
+	} else if (isColorbarFromZero) {
+		if ((cal_minNeg != cal_maxNeg) && ( f < 0.0) && (f > cal_maxNeg))
+			FragColor.a = 0.0;
+		else if ((f > 0.0) && (cal_min > 0.0) && (f < cal_min))
+			FragColor.a *= 0.0;
+
+	}
+	if (modulation == 1) {
+		FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	} else if (modulation == 2) {
+		FragColor.a = texture(modulationVol, vx.xyz).r;
+	}
+	FragColor.a *= opacity;
+	if (layer < 1.0) return;
+	vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+	// https://en.wikipedia.org/wiki/Alpha_compositing
+	float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+	if (aout <= 0.0) return;
+	if (isAdditiveBlend)
+		FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a)) / aout;
+	else
+		FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+	FragColor.a = aout;
+}`,td=`#line 773
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform mat4 mtx;
+uniform bool hasAlpha;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+float textureWidth;
+float nlayer;
+float layerY;
+
+vec4 scalar2color(uint idx) {
+	float fx = (float(idx) + 0.5) / textureWidth;
+	vec4 clr = texture(colormap, vec2(fx, layerY)).rgba;
+	if (clr.a > 0.0)
+		clr.a = 1.0;
+	clr.a *= opacity;
+	return clr;
+}
+
+vec4 paqd2color(uvec4 rgba) {
+  // paqd r: max prob index, g: 2nd index, b: max prob a: 2nd prob
+  float prob1 = float(rgba.b)/255.0;
+  float prob2 = float(rgba.a)/255.0;
+  vec4 clr1 = scalar2color(rgba.r);
+  vec4 clr2 = scalar2color(rgba.g);
+  float total = prob1 + prob2;
+  vec4 clr = vec4(clr1.rgb, total);
+  // vec4 clr = vec4(clr1.rgb, prob1);
+  if (total > 0.0) {
+    clr.rgb = mix(clr2.rgb, clr1.rgb, prob1 / total);
+  }
+  return clr;
+}
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	ivec3 voxelCoord = ivec3(vx.xyz * vec3(textureSize(intensityVol, 0)));
+	uvec4 rgba = texelFetch(intensityVol, voxelCoord, 0);
+	FragColor = vec4(0.0, 0.0, 0.0, 0.0);
+	if (rgba.r > uint(0)) {
+		textureWidth = float(textureSize(colormap, 0).x);
+		nlayer = float(textureSize(colormap, 0).y);
+		layerY = ((2.0 * layer) + 1.5) / nlayer;
+		FragColor = paqd2color(rgba);
+		return;
+	}
+	// if (layer > 2.0) return;
+	// FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+}`,id=`#line 773
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform mat4 mtx;
+uniform bool hasAlpha;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	uvec4 aColor = texture(intensityVol, vx.xyz);
+	FragColor = vec4(float(aColor.r) / 255.0, float(aColor.g) / 255.0, float(aColor.b) / 255.0, float(aColor.a) / 255.0);
+	if (modulation == 1)
+		FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	if (!hasAlpha) {
+		FragColor.a = (FragColor.r * 0.21 + FragColor.g * 0.72 + FragColor.b * 0.07);
+		//next line: we could binarize alpha, but see rendering of visible human
+		//FragColor.a = step(0.01, FragColor.a);
+	}
+	if (modulation == 2)
+		FragColor.a = texture(modulationVol, vx.xyz).r;
+	FragColor.a *= opacity;
+	if (layer < 1.0) return;
+	vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+	// https://en.wikipedia.org/wiki/Alpha_compositing
+	float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+	if (aout <= 0.0) return;
+	FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+	FragColor.a = aout;
+}`,rd=`#version 300 es
+#line 808
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	gl_Position = vec4((vPos.x - 0.5) * 2.0, (vPos.y - 0.5) * 2.0, 0.0, 1.0);
+}`,sd=`#version 300 es
+#line 829
+	precision highp float;
+	precision highp int;
+	precision highp isampler3D;
+	layout(location = 0) out int label;
+	layout(location = 1) out int strength;
+	in vec2 TexCoord;
+	uniform int finalPass;
+	uniform float coordZ;
+	uniform lowp sampler3D in3D;
+	uniform highp isampler3D backTex; // background
+	uniform highp isampler3D labelTex; // label
+	uniform highp isampler3D strengthTex; // strength
+void main(void) {
+	vec3 interpolatedTextureCoordinate = vec3(TexCoord.xy, coordZ);
+	ivec3 size = textureSize(backTex, 0);
+	ivec3 texelIndex = ivec3(floor(interpolatedTextureCoordinate * vec3(size)));
+	int background = texelFetch(backTex, texelIndex, 0).r;
+	label = texelFetch(labelTex, texelIndex, 0).r;
+	strength = texelFetch(strengthTex, texelIndex, 0).r;
+	for (int k = -1; k <= 1; k++) {
+		for (int j = -1; j <= 1; j++) {
+			for (int i = -1; i <= 1; i++) {
+				if (i != 0 && j != 0 && k != 0) {
+					ivec3 neighborIndex = texelIndex + ivec3(i,j,k);
+					int neighborBackground = texelFetch(backTex, neighborIndex, 0).r;
+					int neighborStrength = texelFetch(strengthTex, neighborIndex, 0).r;
+					int strengthCost = abs(neighborBackground - background);
+					int takeoverStrength = neighborStrength - strengthCost;
+					if (takeoverStrength > strength) {
+						strength = takeoverStrength;
+						label = texelFetch(labelTex, neighborIndex, 0).r;
+					}
+				}
+			}
+		}
+	}
+	if (finalPass < 1)
+		return;
+	int ok = 1;
+	ivec4 labelCount = ivec4(0,0,0,0);
+	for (int k = -1; k <= 1; k++)
+		for (int j = -1; j <= 1; j++)
+			for (int i = -1; i <= 1; i++) {
+				ivec3 neighborIndex = texelIndex + ivec3(i,j,k);
+				int ilabel = texelFetch(labelTex, neighborIndex, 0).r;
+				if ((ilabel < 0) || (ilabel > 3))
+					ok = 0;
+				else
+					labelCount[ilabel]++;
+			}
+	if (ok != 1) {
+		return;
+	}
+	int maxIdx = 0;
+	for (int i = 1; i < 4; i++) {
+		if (labelCount[i] > labelCount[maxIdx])
+			maxIdx = i;
+	}
+	label = maxIdx;
+}`,nd=`#version 300 es
+layout(location=0) in vec3 pos;
+uniform mat4 mvpMtx;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+}`,ad=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 surfaceColor;
+out vec4 color;
+void main() {
+	color = surfaceColor;
+}`,od=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 clr;
+out vec4 vClr;
+uniform mat4 mvpMtx;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vClr = clr;
+}`,ld=`#version 300 es
+precision highp int;
+precision highp float;
+in vec4 vClr;
+out vec4 color;
+uniform float opacity;
+void main() {
+	color = vec4(vClr.rgb, opacity);
+}`,Pr=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 norm;
+layout(location=2) in vec4 clr;
+uniform mat4 mvpMtx;
+//uniform mat4 modelMtx;
+uniform mat4 normMtx;
+out vec4 vClr;
+out vec3 vN;
+out vec4 vP;
+out vec4 vPc;
+void main(void) {
+	vec3 lightPosition = vec3(0.0, 0.0, -10.0);
+	vP = vec4(pos, 1.0);
+	vPc = mvpMtx * vec4(pos, 1.0);
+	gl_Position = vPc;
+	vN = normalize((normMtx * vec4(norm.xyz,1.0)).xyz);
+	//vV = -vec3(modelMtx*vec4(pos,1.0));
+	vClr = clr;
+}`,cd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+out vec4 color;
+vec4 packFloatToVec4i(const float value) {
+	const vec4 bitSh = vec4(256.0*256.0*256.0, 256.0*256.0, 256.0, 1.0);
+	const vec4 bitMsk = vec4(0.0, 1.0/256.0, 1.0/256.0, 1.0/256.0);
+	vec4 res = fract(value * bitSh);
+	res -= res.xxyz * bitMsk;
+	return res;
+}
+void main() {
+	color = packFloatToVec4i(gl_FragCoord.z);
+}`,hd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+float stepmix(float edge0, float edge1, float E, float x){
+	float T = clamp(0.5 * (x - edge0 + E) / E, 0.0, 1.0);
+	return mix(edge0, edge1, T);
+}
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0);
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.5;
+	float shininess = 50.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float df = max(0.0, dot(n, l));
+	float sf = pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	const float A = 0.1;
+	const float B = 0.3;
+	const float C = 0.6;
+	const float D = 1.0;
+	float E = fwidth(df);
+	if (df > A - E && df < A + E) df = stepmix(A, B, E, df);
+	else if (df > B - E && df < B + E) df = stepmix(B, C, E, df);
+	else if (df > C - E && df < C + E) df = stepmix(C, D, E, df);
+	else if (df < A) df = 0.0;
+	else if (df < B) df = B;
+	else if (df < C) df = C;
+	else df = D;
+	E = fwidth(sf);
+	if (sf > 0.5 - E && sf < 0.5 + E)
+		sf = smoothstep(0.5 - E, 0.5 + E, sf);
+	else
+		sf = step(0.5, sf);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(df, 0.0) * vClr.rgb * diffuse;
+	color.rgb = a + d + (specular * sf);
+	color.a = opacity;
+}`,dd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.25;
+	float shininess = 10.0;
+	float PenWidth = 0.6;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	float view = abs(dot(n,r)); //with respect to viewer
+	if (PenWidth < view) discard;
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color.rgb = a + d + s;
+	color.a = opacity;
+}`,fd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	const float thresh = 0.4;
+	const vec3 viewDir = vec3(0.0, 0.0, -1.0);
+	vec3 n = normalize(vN);
+	// use abs() for two-sided lighting, max() for one sided
+	float cosTheta = abs(dot(n, viewDir));
+	// float cosTheta = max(dot(n, viewDir), 0.0);
+	// optional fresnel equation - adjust exponent
+	// cosTheta = 1.0 - pow(1.0 - cosTheta, 2.0);
+	// use step for binary edges, smoothstep for feathered edges
+	// vec3 d = step(thresh, cosTheta) * vClr.rgb;
+	vec3 d = smoothstep(thresh - 0.05, thresh + 0.05, cosTheta) * vClr.rgb;
+	color = vec4(d, opacity);
+}`,ud=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+  const float edge0 = 0.1;
+  const float edge1 = 0.25;
+  const vec3 viewDir = vec3(0.0, 0.0, -1.0);
+  vec3 n = normalize(vN);
+  float cosTheta = abs(dot(n, viewDir));
+  float alpha = 1.0 - smoothstep(edge0, edge1, cosTheta);
+  if (alpha <= 0.0) {
+    discard;
+  }
+  color = vec4(0.0, 0.0, 0.0, opacity * alpha);
+}`,md=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float diffuse = 1.0;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 0.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = max(dot(n, l), 0.0);
+	vec3 d = lightNormDot * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(d + s, opacity);
+}`,pd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float diffuse = 1.4;
+	vec3 l = vec3(0.0, 0.0, -1.0);
+	float lightNormDot = max(dot(normalize(vN), l), 0.0);
+	color = vec4(lightNormDot * vClr.rgb * diffuse, opacity);
+}`,gd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float specularRGB = 0.7;
+	float specularWhite = 0.3;
+	float shininess = 10.0;
+	float diffuse = 1.0;
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	vec3 n = normalize(vN);
+	vec3 l = vec3(0.0, 0.0, -1.0);
+	float lightNormDot = max(dot(n, l), 0.0);
+	vec3 d3 = lightNormDot * vClr.rgb * diffuse;
+	float s = pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	vec3 s3 = specularRGB * s * vClr.rgb;
+	s *= specularWhite;
+	color = vec4(d3 + s3 + s, opacity);
+}`,Ad=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+in vec4 vPc;
+out vec4 color;
+void main() {
+	vec3 n = normalize(vN);
+	// Compute curvature
+	vec3 dx = dFdx(n);
+	vec3 dy = dFdy(n);
+	vec3 xneg = n - dx;
+	vec3 xpos = n + dx;
+	vec3 yneg = n - dy;
+	vec3 ypos = n + dy;
+	float depth = length(vPc.xyz);
+	float curv = (cross(xneg, xpos).y - cross(yneg, ypos).x) / depth;
+	//at this stage 0.5 for flat, with valleys dark and ridges bright
+	curv = 1.0 - (curv + 0.5);
+	//clamp
+	curv =  min(max(curv, 0.0), 1.0);
+	// easing function
+	curv = pow(curv, 0.5);
+	//modulate ambient and diffuse with curvature
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.6;
+	float diffuse = 0.6;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 lightPosition = vec3(0.0, 10.0, -2.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient * curv;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,xd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 sliceMM;
+uniform float thickMM ;
+in vec4 vClr;
+in vec4 vP;  // vertex position in mm
+out vec4 color;
+void main() {
+    const float LINE_WIDTH_PX = 4.0;   // target thickness in pixels
+    //const float LINE_THRESH_MM = 1.5;   // target thickness in pixels
+    const float TILT_STRENGTH = 1.0;   // >0 shrinks ribbon for oblique triangles
+    // --- signed distances to each orthogonal plane (object space) ---
+    vec3 d = vP.xyz - sliceMM.xyz;
+    vec3 ad = abs(d);
+    // --- derivatives to get pixel-consistent widths (per-axis) ---
+    vec3 fd = fwidth(vP.xyz);
+    //minDist is in mm not pixels
+    float minDist = min(ad.x, min(ad.y, ad.z));
+    if (minDist >  sliceMM.w) discard;
+    // --- per-plane obliqueness: use the two in-plane components' fwidth ---
+    float tiltX = length(fd.yz); // for plane with normal X
+    float tiltY = length(fd.xz); // for plane with normal Y
+    float tiltZ = length(fd.xy); // for plane with normal Z
+    float tfX = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltX), 0.0, 1.0);
+    float tfY = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltY), 0.0, 1.0);
+    float tfZ = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltZ), 0.0, 1.0);
+    // --- half-widths for each plane (apply per-axis tilt factor) ---
+    vec3 halfWidth;
+    halfWidth.x = (LINE_WIDTH_PX * 0.5) * fd.x * tfX;
+    halfWidth.y = (LINE_WIDTH_PX * 0.5) * fd.y * tfY;
+    halfWidth.z = (LINE_WIDTH_PX * 0.5) * fd.z * tfZ;
+    // --- smooth alpha for each plane ---
+    vec3 edgeA = 1.0 - smoothstep(vec3(0.0), halfWidth, ad);
+    // combine planes (max of X,Y,Z ribbons)
+    float edgeAlpha = max(edgeA.x, max(edgeA.y, edgeA.z));
+    if (edgeAlpha <= 1e-4) discard; // outside ribbons
+    color = vec4(vClr.rgb, vClr.a * edgeAlpha);
+}`,vd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,wd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+uniform sampler2D matCap;
+out vec4 color;
+void main() {
+	vec3 n = normalize(vN);
+	vec2 uv = n.xy * 0.5 + 0.5;
+	uv.y = 1.0 - uv.y;
+	vec3 clr = texture(matCap,uv.xy).rgb * vClr.rgb;
+	color = vec4(clr, opacity);
+}`,yd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float ambient = 0.35;
+	float diffuse = 0.6;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	color = vec4(a + d, opacity);
+}`,bd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 up = vec3(0.0, 1.0, 0.0);
+	float ax = dot(n, up) * 0.5 + 0.5;  //Shreiner et al. (2013) OpenGL Programming Guide, 8th Ed., p 388. ISBN-10: 0321773039
+	vec3 upClr = vec3(1.0, 1.0, 0.95);
+	vec3 downClr = vec3(0.4, 0.4, 0.6);
+	vec3 a = vClr.rgb * ambient;
+	a *= mix(downClr, upClr, ax);
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,Cd=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+//Spherical harmonics constants
+const float C1 = 0.429043;
+const float C2 = 0.511664;
+const float C3 = 0.743125;
+const float C4 = 0.886227;
+const float C5 = 0.247708;
+//Spherical harmonics coefficients
+// Ramamoorthi, R., and P. Hanrahan. 2001b. "An Efficient Representation for Irradiance Environment Maps." In Proceedings of SIGGRAPH 2001, pp. 497–500.
+// https://github.com/eskimoblood/processingSketches/blob/master/data/shader/shinyvert.glsl
+// https://github.com/eskimoblood/processingSketches/blob/master/data/shader/shinyvert.glsl
+// Constants for Eucalyptus Grove lighting
+const vec3 L00  = vec3( 0.3783264,  0.4260425,  0.4504587);
+const vec3 L1m1 = vec3( 0.2887813,  0.3586803,  0.4147053);
+const vec3 L10  = vec3( 0.0379030,  0.0295216,  0.0098567);
+const vec3 L11  = vec3(-0.1033028, -0.1031690, -0.0884924);
+const vec3 L2m2 = vec3(-0.0621750, -0.0554432, -0.0396779);
+const vec3 L2m1 = vec3( 0.0077820, -0.0148312, -0.0471301);
+const vec3 L20  = vec3(-0.0935561, -0.1254260, -0.1525629);
+const vec3 L21  = vec3(-0.0572703, -0.0502192, -0.0363410);
+const vec3 L22  = vec3( 0.0203348, -0.0044201, -0.0452180);
+vec3 SH(vec3 vNormal) {
+	vNormal = vec3(vNormal.x,vNormal.z,vNormal.y);
+	vec3 diffuseColor = C1 * L22 * (vNormal.x * vNormal.x - vNormal.y * vNormal.y) +
+	C3 * L20 * vNormal.z * vNormal.z +
+	C4 * L00 -
+	C5 * L20 +
+	2.0 * C1 * L2m2 * vNormal.x * vNormal.y +
+	2.0 * C1 * L21  * vNormal.x * vNormal.z +
+	2.0 * C1 * L2m1 * vNormal.y * vNormal.z +
+	2.0 * C2 * L11  * vNormal.x +
+	2.0 * C2 * L1m1 * vNormal.y +
+	2.0 * C2 * L10  * vNormal.z;
+	return diffuseColor;
+}
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.1;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = vClr.rgb * diffuse * SH(-reflect(n, vec3(l.x, l.y, -l.z)) );
+	color = vec4(a + d + s, opacity);
+}`,Md=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 norm;
+layout(location=2) in vec4 clr;
+uniform mat4 mvpMtx;
+//uniform mat4 modelMtx;
+uniform mat4 normMtx;
+out vec4 vClr;
+flat out vec3 vN;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vN = normalize((normMtx * vec4(norm.xyz,1.0)).xyz);
+	//vV = -vec3(modelMtx*vec4(pos,1.0));
+	vClr = clr;
+}`,Wn=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+flat in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,Dd=`#version 300 es
+#line 1260
+#define MAX_CLIP_PLANES 6
+//precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 volScale;
+uniform vec3 texVox;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform mat4 matRAS;
+uniform mat4 mvpMtx;
+uniform float drawOpacity, renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+uniform int backgroundMasksOverlays;
+in vec3 vColor;
+out vec4 fColor;
+`+zt+`
+void main() {
+	int id = 254;
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	fColor = vec4(0.0, 0.0, 0.0, 0.0); //assume no hit: ID = 0
+	float fid = float(id & 255)/ 255.0;
+	vec3 backPosition = GetBackPosition(start);
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) return;//discard; //length limit for parallel rays
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	dir = normalize(dir);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	bool hasClip = false;
+	vec2 sampleRange = vec2(0.0, len);
+	for (int i = 0; i < MAX_CLIP_PLANES; i++)
+		clipSampleRange(dir, samplePos, clipPlanes[i], sampleRange, hasClip);
+	bool isClip = (sampleRange.x > 0.0) || ((sampleRange.y < len) && (sampleRange.y > 0.0));
+	//vec4 clipPos = applyClip(dir, samplePos, len, isClip);
+	if (isClip) fColor = vec4(samplePos.xyz, 253.0 / 255.0); //assume no hit: ID = 0
+	if ((isClipCutaway) && (sampleRange.x <= 0.0) && (sampleRange.y >= len)) {
+		//completely clipped, but ray does not intersect plane
+		if (hasClip)
+			samplePos.a = len + 1.0;
+		else
+			sampleRange = vec2(0.0, 0.0);
+	}
+	//start: OPTIONAL fast pass: rapid traversal until first hit
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		float val = texture(volume, samplePos.xyz).a;
+		if (val > 0.01) {
+			fColor = vec4(samplePos.rgb, fid);
+			gl_FragDepth = frac2ndc(samplePos.xyz);
+			break;
+		}
+		samplePos += deltaDirFast; //advance ray position
+	}
+	//end: fast pass
+	if ((overlays < 1.0) || (backgroundMasksOverlays > 0)) {
+		return; //background hit, no overlays
+	}
+	//overlay pass
+	len = min(len, samplePos.a); //only find overlay closer than background
+	samplePos = vec4(start.xyz, 0.0); //ray position
+	while (samplePos.a <= len) {
+		float val = texture(overlay, samplePos.xyz).a;
+		if (val > 0.01) {
+			fColor = vec4(samplePos.rgb, fid);
+			gl_FragDepth = frac2ndc(samplePos.xyz);
+			return;
+		}
+		samplePos += deltaDirFast; //advance ray position
+	}
+	//if (fColor.a == 0.0) discard; //no hit in either background or overlays
+	//you only get here if there is a hit with the background that is closer than any overlay
+}`,Td=`#version 300 es
+// an attribute is an input (in) to a vertex shader.
+// It will receive data from a buffer
+layout(location=0)  in vec3 a_position;
+layout(location=1)  in vec3 a_color;
+// A matrix to transform the positions by
+uniform mat4 u_matrix;
+out vec3 vColor;
+// all shaders have a main function
+void main() {
+	// Multiply the position by the matrix.
+	vec4 pos = vec4(a_position, 1.0);
+	gl_Position = u_matrix * vec4(pos);
+	vColor = a_color;
+}
+`,Sd=`#version 300 es
+precision highp float;
+uniform vec4 u_color;
+in vec3 vColor;
+out vec4 outColor;
+void main() {
+	outColor = vec4(vColor, 1.0);
+}`,Ed=`#version 300 es
+#line 1359
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	vec2 viewCoord = (vPos.xy - 0.5) * 2.0;
+	gl_Position = vec4((vPos.xy - 0.5) * 2.0, 0.0, 1.0);
+}`,Id=`#version 300 es
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform lowp sampler3D in3D;
+void main(void) {
+ FragColor = texture(in3D, vec3(TexCoord.xy, coordZ));
+}`,qt=`#version 300 es
+#line 286
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+    TexCoord = vPos.xy;
+    gl_Position = vec4( (vPos.xy-vec2(0.5,0.5))* 2.0, 0.0, 1.0);
+}`,Fd=`#version 300 es
+#line 298
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+// Optional uniforms for parameterised (2r+1)^3 box blur. When kernelRadius
+// is 0 (default / gradient pipeline) the legacy 8-corner sample is used.
+uniform int kernelRadius;
+uniform bool binarize;
+uniform highp sampler3D intensityVol;
+void main(void) {
+ vec3 vx = vec3(TexCoord.xy, coordZ);
+ if (kernelRadius > 0) {
+  vec4 sum = vec4(0.0);
+  float count = 0.0;
+  for (int k = -kernelRadius; k <= kernelRadius; k++) {
+   for (int j = -kernelRadius; j <= kernelRadius; j++) {
+    for (int i = -kernelRadius; i <= kernelRadius; i++) {
+     vec3 off = vec3(float(i) * dX, float(j) * dY, float(k) * dZ);
+     vec4 v = texture(intensityVol, vx + off);
+     if (binarize) v = vec4(v.r > 0.0 ? 1.0 : 0.0, 0.0, 0.0, 0.0);
+     sum += v;
+     count += 1.0;
+    }
+   }
+  }
+  FragColor = sum / count;
+  return;
+ }
+ // Legacy 8-corner box blur (gradient pipeline)
+ vec4 samp = texture(intensityVol,vx+vec3(+dX,+dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,+dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,-dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,-dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,+dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,+dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,-dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,-dY,-dZ));
+ FragColor = samp*0.125;
+}`,Bd=`#version 300 es
+#line 298
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform highp sampler3D intensityVol;
+void main(void) {
+  vec3 vx = vec3(TexCoord.xy, coordZ);
+  // --- Z+ Plane (+dZ) ---
+  float XYZ = texture(intensityVol, vx + vec3(+dX, +dY, +dZ)).a;
+  float OYZ = texture(intensityVol, vx + vec3(0.0, +dY, +dZ)).a;
+  float xYZ = texture(intensityVol, vx + vec3(-dX, +dY, +dZ)).a;
+  float XOZ = texture(intensityVol, vx + vec3(+dX, 0.0, +dZ)).a;
+  float OOZ = texture(intensityVol, vx + vec3(0.0, 0.0, +dZ)).a;
+  float xOZ = texture(intensityVol, vx + vec3(-dX, 0.0, +dZ)).a;
+  float XyZ = texture(intensityVol, vx + vec3(+dX, -dY, +dZ)).a;
+  float OyZ = texture(intensityVol, vx + vec3(0.0, -dY, +dZ)).a;
+  float xyZ = texture(intensityVol, vx + vec3(-dX, -dY, +dZ)).a;
+  // --- Z0 Plane (0.0) ---
+  float XYO = texture(intensityVol, vx + vec3(+dX, +dY, 0.0)).a;
+  float OYO = texture(intensityVol, vx + vec3(0.0, +dY, 0.0)).a;
+  float xYO = texture(intensityVol, vx + vec3(-dX, +dY, 0.0)).a;
+  float XOO = texture(intensityVol, vx + vec3(+dX, 0.0, 0.0)).a;
+  float OOO = texture(intensityVol, vx + vec3(0.0, 0.0, 0.0)).a;
+  float xOO = texture(intensityVol, vx + vec3(-dX, 0.0, 0.0)).a;
+  float XyO = texture(intensityVol, vx + vec3(+dX, -dY, 0.0)).a;
+  float OyO = texture(intensityVol, vx + vec3(0.0, -dY, 0.0)).a;
+  float xyO = texture(intensityVol, vx + vec3(-dX, -dY, 0.0)).a;
+  // --- Z- Plane (-dZ) ---
+  float XYz = texture(intensityVol, vx + vec3(+dX, +dY, -dZ)).a;
+  float OYz = texture(intensityVol, vx + vec3(0.0, +dY, -dZ)).a;
+  float xYz = texture(intensityVol, vx + vec3(-dX, +dY, -dZ)).a;
+  float XOz = texture(intensityVol, vx + vec3(+dX, 0.0, -dZ)).a;
+  float OOz = texture(intensityVol, vx + vec3(0.0, 0.0, -dZ)).a;
+  float xOz = texture(intensityVol, vx + vec3(-dX, 0.0, -dZ)).a;
+  float Xyz = texture(intensityVol, vx + vec3(+dX, -dY, -dZ)).a;
+  float Oyz = texture(intensityVol, vx + vec3(0.0, -dY, -dZ)).a;
+  float xyz = texture(intensityVol, vx + vec3(-dX, -dY, -dZ)).a;
+  // --- Directional blur sums ---
+  vec3 blurred;
+  blurred.x = 2.0 * (xOz + xOZ + xyO + xYO + xOO + XOz + XOZ + XyO + XYO + XOO)
+              + xyz + xyZ + xYz + xYZ + Xyz + XyZ + XYz + XYZ;
+  blurred.y = 2.0 * (Oyz + OyZ + xyO + XyO + OyO + OYz + OYZ + xYO + XYO + OYO)
+              + xyz + Xyz + xyZ + XyZ + xYz + XYz + xYZ + XYZ;
+  blurred.z = 2.0 * (Oyz + OYz + xOz + XOz + OOz + OyZ + OYZ + xOZ + XOZ + OOZ)
+              + xyz + Xyz + xYz + XYz + xyZ + XyZ + xYZ + XYZ;
+  float finalAlpha = 0.32 * (abs(blurred.x) + abs(blurred.y) + abs(blurred.z));
+  // 0.0357 = 1/28 to account for weights, rescale to 2**16,
+  FragColor = 0.0357 * vec4(blurred, finalAlpha);
+}`,Kn=`
+  gradientSample.a = log2(gradientSample.r*gradientSample.r + gradientSample.g*gradientSample.g + gradientSample.b*gradientSample.b + 1.922337562475971e-06) + 18.988706873717717;
+`,Ud=`#version 300 es
+#line 323
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform highp sampler3D intensityVol;
+void main(void) {
+  vec3 vx = vec3(TexCoord.xy, coordZ);
+  //Neighboring voxels 'T'op/'B'ottom, 'A'nterior/'P'osterior, 'R'ight/'L'eft
+  float TAR = texture(intensityVol,vx+vec3(+dX,+dY,+dZ)).a;
+  float TAL = texture(intensityVol,vx+vec3(+dX,+dY,-dZ)).a;
+  float TPR = texture(intensityVol,vx+vec3(+dX,-dY,+dZ)).a;
+  float TPL = texture(intensityVol,vx+vec3(+dX,-dY,-dZ)).a;
+  float BAR = texture(intensityVol,vx+vec3(-dX,+dY,+dZ)).a;
+  float BAL = texture(intensityVol,vx+vec3(-dX,+dY,-dZ)).a;
+  float BPR = texture(intensityVol,vx+vec3(-dX,-dY,+dZ)).a;
+  float BPL = texture(intensityVol,vx+vec3(-dX,-dY,-dZ)).a;
+  vec4 gradientSample = vec4 (0.0, 0.0, 0.0, 0.0);
+  gradientSample.r = BAR+BAL+BPR+BPL -TAR-TAL-TPR-TPL;
+  gradientSample.g = TPR+TPL+BPR+BPL -TAR-TAL-BAR-BAL;
+  gradientSample.b = TAL+TPL+BAL+BPL -TAR-TPR-BAR-BPR;
+${Kn}
+	// 0.04242020977371934 = 1/(log2(3*8) - log2(1/(255**2*8))) // 3*8 -> max for 1st order gradient
+	gradientSample.a *= 0.04242020977371934;
+  float gradLen = length(gradientSample.rgb);
+  gradientSample.rgb = gradLen > 0.001 ? gradientSample.rgb / gradLen : vec3(0.0);
+  gradientSample.rgb = (gradientSample.rgb * 0.5)+0.5;
+  FragColor = gradientSample;
+}`,Rd=`#version 300 es
+#line 323
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform float dX2;
+uniform float dY2;
+uniform float dZ2;
+uniform highp sampler3D intensityVol;
+void main(void) {
+  vec3 vx = vec3(TexCoord.xy, coordZ);
+  //Neighboring voxels 'T'op/'B'ottom, 'A'nterior/'P'osterior, 'R'ight/'L'eft
+  vec4 TAR = texture(intensityVol,vx+vec3(+dX,+dY,+dZ));
+  vec4 TAL = texture(intensityVol,vx+vec3(+dX,+dY,-dZ));
+  vec4 TPR = texture(intensityVol,vx+vec3(+dX,-dY,+dZ));
+  vec4 TPL = texture(intensityVol,vx+vec3(+dX,-dY,-dZ));
+  vec4 BAR = texture(intensityVol,vx+vec3(-dX,+dY,+dZ));
+  vec4 BAL = texture(intensityVol,vx+vec3(-dX,+dY,-dZ));
+  vec4 BPR = texture(intensityVol,vx+vec3(-dX,-dY,+dZ));
+  vec4 BPL = texture(intensityVol,vx+vec3(-dX,-dY,-dZ));
+  vec4 T = texture(intensityVol,vx+vec3(+dX2,0.0,0.0));
+  vec4 A = texture(intensityVol,vx+vec3(0.0,+dY2,0.0));
+  vec4 R = texture(intensityVol,vx+vec3(0.0,0.0,+dZ2));
+  vec4 B = texture(intensityVol,vx+vec3(-dX2,0.0,0.0));
+  vec4 P = texture(intensityVol,vx+vec3(0.0,-dY2,0.0));
+  vec4 L = texture(intensityVol,vx+vec3(0.0,0.0,-dZ2));
+  vec4 gradientSample = vec4 (0.0, 0.0, 0.0, 0.0);
+  gradientSample.x = -4.0*B.x +8.0*(BAR.x+BAL.x+BPR.x+BPL.x) -8.0*(TAR.x+TAL.x+TPR.x+TPL.x) +4.0*T.x;
+  gradientSample.y = -4.0*P.y +8.0*(TPR.y+TPL.y+BPR.y+BPL.y) -8.0*(TAR.y+TAL.y+BAR.y+BAL.y) +4.0*A.y;
+  gradientSample.z = -4.0*L.z +8.0*(TAL.z+TPL.z+BAL.z+BPL.z) -8.0*(TAR.z+TPR.z+BAR.z+BPR.z) +4.0*R.z;
+${Kn}
+	gradientSample.a *= 0.0325;
+  float gradLen = length(gradientSample.xyz);
+  gradientSample.xyz = gradLen > 0.001 ? gradientSample.xyz / gradLen : vec3(0.0);
+  gradientSample.xyz =  (gradientSample.xyz * 0.5)+0.5;
+  FragColor = gradientSample;
+}`;function Vd(){return[{Name:"Phong",Frag:vd},{Name:"Matte",Frag:yd},{Name:"Harmonic",Frag:Cd},{Name:"Hemispheric",Frag:bd},{Name:"Crevice",Frag:Ad},{Name:"Edge",Frag:md},{Name:"Diffuse",Frag:pd},{Name:"Outline",Frag:dd},{Name:"Specular",Frag:gd},{Name:"Toon",Frag:hd},{Name:"Flat",Frag:Wn},{Name:"Matcap",Frag:wd},{Name:"Rim",Frag:fd},{Name:"Silhouette",Frag:ud},{Name:"Crosscut",Frag:xd}]}function It(t){const{gl:e,shader:i,gradientAmount:r=0,renderDrawAmbientOcclusion:s,renderSilhouette:n,gradientOpacity:a}=t;i.use(e),e.uniform1i(i.uniforms.volume,0),e.uniform1i(i.uniforms.colormap,1),e.uniform1i(i.uniforms.overlay,2),e.uniform1i(i.uniforms.drawing,7),e.uniform1i(i.uniforms.drawSmoothed,10),e.uniform1f(i.uniforms.smoothDrawing,0),e.uniform1i(i.uniforms.paqd,8),e.uniform1fv(i.uniforms.renderDrawAmbientOcclusion,[s,1]),e.uniform1f(i.uniforms.gradientAmount,r),e.uniform1f(i.uniforms.silhouettePower,n);const o=new Float32Array(Bt);for(let l=0;l<Bt;l++)a===0?o[l]=1:o[l]=Math.pow(l/(Bt-1),a*8);e.uniform1fv(e.getUniformLocation(i.program,"gradientOpacity"),o),i.uniforms.clipPlanes=e.getUniformLocation(i.program,"clipPlanes[0]")}function Pd(t){const{gl:e,fragmentShaderText:i,drawOpacity:r,customSliceShader:s}=t;if(s&&e.deleteProgram(s.program),!i)return null;const n=new ee(e,li,i);return n.use(e),e.uniform1i(n.uniforms.volume,0),e.uniform1i(n.uniforms.colormap,1),e.uniform1i(n.uniforms.overlay,2),e.uniform1i(n.uniforms.drawing,7),e.uniform1i(n.uniforms.paqd,8),e.uniform1f(n.uniforms.drawOpacity,r),n}function Hn(t,e){const i=t.toLowerCase();for(let r=0;r<e.length;r++)if(e[r].Name.toLowerCase()===i)return r}function Nd(t){const{gl:e,fragmentShaderText:i,name:r,meshShaders:s}=t;if(!i)throw new Error("Need fragment shader");const n=Hn(r,s);if(n!==void 0&&n>=0){const o=s[n].shader;o&&e.deleteProgram(o.program),s.splice(n,1)}const a=new ee(e,Pr,i);return a.use(e),{Name:r,Frag:i,shader:a}}function Ld(t,e=!0){const i=t.map(r=>r.Name);return e?i.sort():i}function kd(t,e){const i=new ee(t,li,z0);i.use(t),t.uniform1i(i.uniforms.volume,0),t.uniform1i(i.uniforms.colormap,1),t.uniform1i(i.uniforms.overlay,2),t.uniform1i(i.uniforms.drawing,7),t.uniform1f(i.uniforms.drawOpacity,e);const r=new ee(t,li,G0);r.use(t),t.uniform1i(r.uniforms.volume,0),t.uniform1i(r.uniforms.colormap,1),t.uniform1i(r.uniforms.overlay,2),t.uniform1i(r.uniforms.drawing,7),t.uniform1f(r.uniforms.drawOpacity,e);const s=new ee(t,li,Y0);return s.use(t),t.uniform1i(s.uniforms.volume,0),t.uniform1i(s.uniforms.colormap,1),t.uniform1i(s.uniforms.overlay,2),t.uniform1i(s.uniforms.drawing,7),t.uniform1f(s.uniforms.drawOpacity,e),{slice2DShader:i,sliceMMShader:r,sliceV1Shader:s}}function Od(t,e,i){const r=new ee(t,Td,Sd),s=t.createVertexArray();t.bindVertexArray(s);const n=t.createBuffer();return t.enableVertexAttribArray(0),t.enableVertexAttribArray(1),t.bindBuffer(t.ARRAY_BUFFER,n),t.bufferData(t.ARRAY_BUFFER,e,t.STATIC_DRAW),t.vertexAttribPointer(0,3,t.FLOAT,!1,24,0),t.enableVertexAttribArray(1),t.vertexAttribPointer(1,3,t.FLOAT,!1,24,12),t.bindVertexArray(i),{shader:r,vao:s}}function zd(t){const e=new ee(t,bs,Ni);e.use(t);const i=new ee(t,bs,X0);i.use(t);const r=new ee(t,H0,Ni);r.use(t);const s=new ee(t,q0,Ni);s.use(t);const n=new ee(t,J0,$0);return n.use(t),{rectShader:e,rectOutlineShader:i,lineShader:r,line3DShader:s,circleShader:n}}function Gd(t){const{gl:e,renderDrawAmbientOcclusion:i,renderSilhouette:r,gradientOpacity:s}=t,n=new ee(e,Et,L0);It({gl:e,shader:n,renderDrawAmbientOcclusion:i,renderSilhouette:r,gradientOpacity:s});const a=new ee(e,Et,N0);It({gl:e,shader:a,renderDrawAmbientOcclusion:i,renderSilhouette:r,gradientOpacity:s});const o=new ee(e,Et,k0);It({gl:e,shader:o,gradientAmount:.3,renderDrawAmbientOcclusion:i,renderSilhouette:r,gradientOpacity:s}),e.uniform1i(o.uniforms.matCap,5),e.uniform1i(o.uniforms.gradient,6);const l=new ee(e,Et,O0);return It({gl:e,shader:l,renderDrawAmbientOcclusion:i,renderSilhouette:r,gradientOpacity:s}),e.uniform1i(l.uniforms.matCap,5),e.uniform1i(l.uniforms.gradient,6),{renderVolumeShader:n,renderSliceShader:a,renderGradientShader:o,renderGradientValuesShader:l,renderShader:n}}function Yd(t){const e=new ee(t,W0,K0);return e.use(t),t.uniform1i(e.uniforms.colormap,1),e}function Xd(t){const e=new ee(t,qt,Fd),i=new ee(t,qt,Bd),r=new ee(t,qt,Ud),s=new ee(t,qt,Rd),n=new ee(t,rd,sd),a=new ee(t,Ed,Id);return{blurShader:e,gradientPrePassShader:i,sobelFirstOrderShader:r,sobelSecondOrderShader:s,growCutShader:n,passThroughShader:a}}function Wd(t){const e=new ee(t,Je,Ht.concat(Ms)),i=new ee(t,Je,Cs.concat(Ms)),r=new ee(t,Je,Ht.concat(Li)),s=new ee(t,Je,Cs.concat(Li)),n=new ee(t,Je,ed.concat(Li)),a=new ee(t,Je,Ht.concat(id)),o=new ee(t,Je,Ht.concat(td));return{orientShaderAtlasU:e,orientShaderAtlasI:i,orientShaderU:r,orientShaderI:s,orientShaderF:n,orientShaderRGBU:a,orientShaderPAQD:o}}function Kd(t){const e=new ee(t,nd,ad);e.use(t);const i=new ee(t,od,ld);return{surfaceShader:e,fiberShader:i}}function Hd(t){const e=new ee(t,Et,Dd);return e.use(t),e.uniforms.clipPlanes=t.getUniformLocation(e.program,"clipPlanes[0]"),t.uniform1i(e.uniforms.volume,0),t.uniform1i(e.uniforms.colormap,1),t.uniform1i(e.uniforms.overlay,2),t.uniform1i(e.uniforms.drawing,7),e}function qd(t,e){for(let i=0;i<e.length;i++){const r=e[i];r.Name==="Flat"?r.shader=new ee(t,Md,Wn):r.shader=new ee(t,Pr,r.Frag),r.shader.use(t),r.shader.isCrosscut=r.Name==="Crosscut",r.shader.isMatcap=r.Name==="Matcap",r.shader.isMatcap&&t.uniform1i(r.shader.uniforms.matCap,5)}}function Qd(t,e){const i=[...t,e],r=i.length===1?0:i.length-1;return{volumes:i,index:r}}function At(t,e){for(let i=0;i<t.length;i++)if(t[i].id===e)return i;return-1}function Zd(t,e){const i=t.slice(1);for(let r=0;r<i.length;r++)if(i[r].id===e)return r;return-1}function xt(t,e,i=0){const r=t.length;if(i>r)return{volumes:t,back:t.length>0?t[0]:null,overlays:t.slice(1)};const s=At(t,e.id),n=[...t];return i===0?(n.splice(s,1),n.unshift(e)):i<0?n.splice(s,1):(n.splice(s,1),n.splice(i,0,e)),{volumes:n,back:n.length>0?n[0]:null,overlays:n.slice(1)}}function qn(t,e){return{volumes:xt(t,e,-1).volumes,removed:e}}function jd(t,e){if(e>=t.length)throw new Error("Index of volume out of bounds");return qn(t,t[e])}function _d(t,e){return xt(t,e,0)}function Jd(t,e){const i=At(t,e.id);return xt(t,e,i+1)}function $d(t,e){const i=At(t,e.id);return xt(t,e,i-1)}function ef(t,e){return xt(t,e,t.length-1)}function tf(t,e,i){return t[e].opacity=i,t}function rf(t,e){return t[e].clone()}function sf(t,e,i){const r=At(t,e);if(r<0)return t;const s=t[r];let n=i;return n>s.nFrame4D-1&&(n=s.nFrame4D-1),n<0&&(n=0),n===s.frame4D||(s.frame4D=n),t}function nf(t,e){const i=At(t,e);return i<0?0:t[i].frame4D}function af(t){const e=t.hdr,i=e.dims[1]*e.dims[2]*e.dims[3],r=new Uint8ClampedArray(i*4),s=.2*Math.min(Math.min(e.dims[1],e.dims[2]),e.dims[3]),n=.5*e.dims[1],a=.5*e.dims[2],o=.5*e.dims[3];let l=0;for(let c=0;c<e.dims[3];c++)for(let h=0;h<e.dims[2];h++)for(let d=0;d<e.dims[1];d++){const f=Math.abs(d-n),u=Math.abs(h-a),m=Math.abs(c-o),p=Math.sqrt(f*f+u*u+m*m);let g=0;p<s&&(g=255),r[l++]=0,r[l++]=g,r[l++]=0,r[l++]=g*.5}return r}function of(t){let e=t.img;return t.frame4D>0&&t.frame4D<t.nFrame4D&&(e=t.img.slice(t.frame4D*t.nVox3D,(t.frame4D+1)*t.nVox3D)),e}function lf(t){const{hdr:e,max2D:i,max3D:r}=t,s=e.dims[1]>i||e.dims[2]>i,n=e.dims[1]>r||e.dims[2]>r||e.dims[3]>r;return{isAboveMax2D:s,isAboveMax3D:n}}function cf(t){const{gl:e,overlayItem:i,orientShader:r,createColormapTexture:s}=t;if(i.colormapLabel===null||i.colormapLabel.lut.length<=7)return{colormapLabelTexture:null,shouldCleanup:!1};const n=i.colormapLabel.max-i.colormapLabel.min+1,a=s(null,1,n);return e.texSubImage2D(e.TEXTURE_2D,0,0,0,n,1,e.RGBA,e.UNSIGNED_BYTE,i.colormapLabel.lut),e.uniform1f(r.uniforms.cal_min,i.colormapLabel.min-.5),e.uniform1f(r.uniforms.cal_max,i.colormapLabel.max+.5),e.bindTexture(e.TEXTURE_2D,a),{colormapLabelTexture:a,shouldCleanup:!0}}function hf(t){const{gl:e,overlayItem:i,hdr:r,volumes:s,orientShader:n,r8Tex:a,TEXTURE7:o}=t;if(i.modulationImage===null||i.modulationImage<0||i.modulationImage>=s.length)return e.uniform1i(n.uniforms.modulation,0),{modulateTexture:null};const l=s[i.modulationImage].hdr;if(l.dims[1]!==r.dims[1]||l.dims[2]!==r.dims[2]||l.dims[3]!==r.dims[3])return F.debug("Modulation image dimensions do not match target"),e.uniform1i(n.uniforms.modulation,0),{modulateTexture:null};F.debug("modulating",s),i.modulateAlpha?(e.uniform1i(n.uniforms.modulation,2),e.uniform1f(n.uniforms.opacity,1)):e.uniform1i(n.uniforms.modulation,1);const c=a(null,o,r.dims,!0);e.activeTexture(o),e.bindTexture(e.TEXTURE_3D,c);const h=r.dims[1]*r.dims[2]*r.dims[3],d=new Uint8Array(h),f=s[i.modulationImage].cal_min,u=1/(s[i.modulationImage].cal_max-f),m=s[i.modulationImage].img.buffer;let p=new Uint8Array(m);switch(l.datatypeCode){case 4:p=new Int16Array(m);break;case 16:p=new Float32Array(m);break;case 64:p=new Float64Array(m);break;case 128:p=new Uint8Array(m);break;case 512:p=new Uint16Array(m);break}F.debug(s[i.modulationImage]);const g=s[i.modulationImage].colormapNegative.length>0;let x=s[i.modulationImage].cal_min,A=s[i.modulationImage].cal_max;isFinite(s[i.modulationImage].cal_minNeg)&&isFinite(s[i.modulationImage].cal_maxNeg)&&(x=s[i.modulationImage].cal_minNeg,A=s[i.modulationImage].cal_maxNeg),x=Math.abs(x),A=Math.abs(A),x>A&&([x,A]=[A,x]);const y=1/(A-x);let v=Math.abs(i.modulateAlpha);v=Math.max(v,1);const b=s[i.modulationImage].frame4D*h;for(let w=0;w<h;w++){const C=p[w+b]*l.scl_slope+l.scl_inter;let M=(C-f)*u;g&&C<0&&(M=(Math.abs(C)-x)*y),M=Math.min(Math.max(M,0),1),M=Math.pow(M,v)*255,d[w]=M}return e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,r.dims[1],r.dims[2],r.dims[3],e.RED,e.UNSIGNED_BYTE,d),{modulateTexture:c}}function df(t,e,i){if(!t.dimsRAS||!t.matRAS||!t.pixDimsRAS||!t.vox2mm)throw new Error("Cannot create NiivueObject3D: Missing required RAS properties or vox2mm access on NVImage.");const r=t.dimsRAS,s=t.matRAS,n=t.pixDimsRAS,a=-.5,o=-.5,l=-.5,c=r[1]-1+.5,h=r[2]-1+.5,d=r[3]-1+.5,f=t.vox2mm,u=f.call(t,[a,o,l],s),m=f.call(t,[a,h,l],s),p=f.call(t,[a,o,d],s),g=f.call(t,[a,h,d],s),x=f.call(t,[c,o,l],s),A=f.call(t,[c,h,l],s),y=f.call(t,[c,o,d],s),v=f.call(t,[c,h,d],s),b=[...p,0,0,1,...y,1,0,1,...v,1,1,1,...g,0,1,1,...u,0,0,0,...m,0,1,0,...A,1,1,0,...x,1,0,0],w=i.createBuffer();if(!w)throw new Error("Failed to create GL index buffer");i.bindBuffer(i.ELEMENT_ARRAY_BUFFER,w);const C=[0,3,2,2,1,0,4,7,6,6,5,4,5,6,2,2,3,5,4,0,1,1,7,4,7,1,2,2,6,7,4,5,3,3,0,4];i.bufferData(i.ELEMENT_ARRAY_BUFFER,new Uint16Array(C),i.STATIC_DRAW);const M=i.createBuffer();if(!M)throw new Error("Failed to create GL vertex buffer");i.bindBuffer(i.ARRAY_BUFFER,M),i.bufferData(i.ARRAY_BUFFER,new Float32Array(b),i.STATIC_DRAW);const T=i.createVertexArray();if(!T)throw new Error("Failed to create GL VAO");i.bindVertexArray(T),i.bindBuffer(i.ELEMENT_ARRAY_BUFFER,w),i.bindBuffer(i.ARRAY_BUFFER,M);const E=24;i.enableVertexAttribArray(0),i.vertexAttribPointer(0,3,i.FLOAT,!1,E,0),i.enableVertexAttribArray(1),i.vertexAttribPointer(1,3,i.FLOAT,!1,E,12),i.bindVertexArray(null);const I=new st(e,M,i.TRIANGLES,C.length,w,T),S=[...p,...y,...v,...g,...u,...m,...A,...x],U=eh(S);return I.extentsMin=U.min.slice(),I.extentsMax=U.max.slice(),I.furthestVertexFromOrigin=U.furthestVertexFromOrigin,I.originNegate=Ve(U.origin),Ia(I.originNegate,I.originNegate),I.fieldOfViewDeObliqueMM=[r[1]*n[1],r[2]*n[2],r[3]*n[3]],I}var ff=33984,uf=33986,Ds=33994;function mf(t){const{overlayItem:e,VOLUME_ID:i,gl:r}=t;return df(e,i,r)}function pf(t){const{overlayItem:e,mm2frac:i}=t,r=i(e.mm000,0,!0);let s=i(e.mm100,0,!0),n=i(e.mm010,0,!0),a=i(e.mm001,0,!0);s=ne(s,s,r),n=ne(n,n,r),a=ne(a,a,r);const o=Ee(s[0],n[0],a[0],r[0],s[1],n[1],a[1],r[1],s[2],n[2],a[2],r[2],0,0,0,1);return Se(o,o),o}function gf(t){const{layer:e,backDims:i,rgbaTex:r}=t;if(e===0)return{volumeTexture:r(null,ff,i)};if(e===1){const s=r(null,uf,i);return{overlayTexture:s,overlayTextureID:s}}return{}}function Af(t){const e=t.createFramebuffer();return t.bindFramebuffer(t.FRAMEBUFFER,e),t.disable(t.CULL_FACE),t.disable(t.BLEND),e}function xf(t){const{gl:e,layer:i,backDims:r,rgbaTex:s,passThroughShader:n}=t;if(i<=1)return s(null,Ds,[2,2,2,2]);const a=s(null,Ds,r);e.bindTexture(e.TEXTURE_3D,a),n.use(e),e.uniform1i(n.uniforms.in3D,2);for(let o=0;o<r[3];o++){const l=1/r[3]*(o+.5);e.uniform1f(n.uniforms.coordZ,l),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,a,0,o),e.drawArrays(e.TRIANGLE_STRIP,0,4)}return a}function vf(t){const{gl:e,overlayItem:i,orientShader:r,layer:s,isAdditiveBlend:n}=t,a=i.colormapType!==0?1:0,o=i.colormapType===1?1:0;e.uniform1i(r.uniforms.isAlphaThreshold,o),e.uniform1i(r.uniforms.isColorbarFromZero,a),e.uniform1i(r.uniforms.isAdditiveBlend,n?1:0);let l=Number.POSITIVE_INFINITY,c=Number.NEGATIVE_INFINITY;i.colormapNegative.length>0&&(l=Math.min(-i.cal_min,-i.cal_max),c=Math.max(-i.cal_min,-i.cal_max),isFinite(i.cal_minNeg)&&isFinite(i.cal_maxNeg)&&(l=Math.min(i.cal_minNeg,i.cal_maxNeg),c=Math.max(i.cal_minNeg,i.cal_maxNeg))),e.uniform1f(r.uniforms.layer??null,s),e.uniform1f(r.uniforms.cal_minNeg??null,l),e.uniform1f(r.uniforms.cal_maxNeg??null,c)}function wf(t){const{gl:e,orientShader:i,backDims:r,outTexture:s,mtx:n,hdr:a,intensityVolTextureUnit:o,blendTextureUnit:l,colormapTextureUnit:c,modulationTextureUnit:h,opacity:d,atlasOutline:f,atlasActiveIndex:u}=t;i.use(e),e.uniform1i(i.uniforms.intensityVol??null,o),e.uniform1i(i.uniforms.blend3D??null,l),e.uniform1i(i.uniforms.colormap??null,c),e.uniform1f(i.uniforms.scl_inter??null,a.scl_inter),e.uniform1f(i.uniforms.scl_slope??null,a.scl_slope),e.uniform1f(i.uniforms.opacity??null,d),e.uniform1i(i.uniforms.modulationVol??null,h),e.uniformMatrix4fv(i.uniforms.mtx,!1,n);let m=0;a.intent_code===1002&&(m=f,e.uniform1ui(i.uniforms.activeIndex,u|0)),e.uniform4fv(i.uniforms.xyzaFrac,[1/r[1],1/r[2],1/r[3],m]);for(let p=0;p<r[3];p++){const g=1/r[3]*(p+.5);e.uniform1f(i.uniforms.coordZ,g),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,s,0,p),e.drawArrays(e.TRIANGLE_STRIP,0,4)}}function yf(t){const{gl:e,renderShader:i,pickingImageShader:r,sliceShader:s,overlaysLength:n,clipPlaneColor:a,backOpacity:o,renderOverlayBlend:l,clipPlane:c,texVox:h,volScale:d,drawOpacity:f,paqdUniforms:u}=t;i.use(e),e.uniform1f(i.uniforms.overlays,n),e.uniform4fv(i.uniforms.clipPlaneColor,a),e.uniform1f(i.uniforms.backOpacity,o),e.uniform1f(i.uniforms.renderOverlayBlend,l),e.uniform4fv(i.uniforms.clipPlane,c),e.uniform3fv(i.uniforms.texVox,h),e.uniform3fv(i.uniforms.volScale,d),r.use(e),e.uniform1f(r.uniforms.overlays,n),e.uniform3fv(r.uniforms.texVox,h),s.use(e),e.uniform1f(s.uniforms.overlays,n),e.uniform1f(s.uniforms.drawOpacity,f),e.uniform4fv(s.uniforms.paqdUniforms,u)}function bf(t){const{is2DSliceShader:e,isV1SliceShader:i,sliceMMShader:r,slice2DShader:s,sliceV1Shader:n,customSliceShader:a}=t;let o=r;if(e&&(o=s),i&&(o=n),a&&(o=a),!o)throw new Error("slice shader undefined");return o}function Cf(t){const{gl:e,shader:i,is2DSliceShader:r,drawTexture:s,paqdTexture:n,TEXTURE7_DRAW:a,TEXTURE8_PAQD:o}=t;e.uniform1i(i.uniforms.drawing,7),e.activeTexture(a),r?e.bindTexture(e.TEXTURE_2D,s):e.bindTexture(e.TEXTURE_3D,s),e.uniform1i(i.uniforms.paqd,8),e.activeTexture(o),e.bindTexture(e.TEXTURE_3D,n)}function Mf(t){const{gl:e,TEXTURE9_ORIENT:i}=t,r=e.createTexture();return e.activeTexture(i),e.bindTexture(e.TEXTURE_3D,r),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MIN_FILTER,e.NEAREST),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MAG_FILTER,e.NEAREST),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_WRAP_R,e.CLAMP_TO_EDGE),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_WRAP_S,e.CLAMP_TO_EDGE),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_WRAP_T,e.CLAMP_TO_EDGE),e.pixelStorei(e.UNPACK_ALIGNMENT,1),r}var Df=2,Tf=4,Sf=16,Ef=64,If=128,Ff=512,Bf=2304,ki=1002;function Uf(t){const{gl:e,hdr:i,img:r,orientShaderU:s,orientShaderI:n,orientShaderF:a,orientShaderRGBU:o,orientShaderAtlasU:l,orientShaderAtlasI:c}=t;let h=s;if(i.datatypeCode===Df)i.intent_code===ki&&(h=l),e.texStorage3D(e.TEXTURE_3D,1,e.R8UI,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RED_INTEGER,e.UNSIGNED_BYTE,r);else if(i.datatypeCode===Tf)h=n,i.intent_code===ki&&(h=c),e.texStorage3D(e.TEXTURE_3D,1,e.R16I,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RED_INTEGER,e.SHORT,r);else if(i.datatypeCode===Sf)e.texStorage3D(e.TEXTURE_3D,1,e.R32F,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RED,e.FLOAT,r),h=a;else if(i.datatypeCode===Ef){const d=Float32Array.from(r);e.texStorage3D(e.TEXTURE_3D,1,e.R32F,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RED,e.FLOAT,d),h=a}else i.datatypeCode===If?(h=o,h.use(e),e.uniform1i(h.uniforms.hasAlpha,0),e.texStorage3D(e.TEXTURE_3D,1,e.RGB8UI,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RGB_INTEGER,e.UNSIGNED_BYTE,r)):i.datatypeCode===Ff&&(i.intent_code===ki&&(h=l),e.texStorage3D(e.TEXTURE_3D,1,e.R16UI,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RED_INTEGER,e.UNSIGNED_SHORT,r));return{orientShader:h}}function Rf(t){const{gl:e,hdr:i,img:r,overlayItem:s,layer:n,orientShaderRGBU:a,orientShaderPAQD:o,volumes:l,backDims:c,rgbaTex:h,paqdTexture:d,TEXTURE8_PAQD:f,TEXTURE9_ORIENT:u}=t;let m=a,p=null,g=d;if(s.colormapLabel){m=o;let x=!0;for(let A=0;A<n;A++){const y=l[A].hdr.datatypeCode===Bf,v=!!l[A].colormapLabel;y&&v&&(x=!1)}x&&(g=h(d,f,c)),p=g,e.activeTexture(u)}return m.use(e),e.uniform1i(m.uniforms.hasAlpha,1),e.texStorage3D(e.TEXTURE_3D,1,e.RGBA8UI,i.dims[1],i.dims[2],i.dims[3]),e.texSubImage3D(e.TEXTURE_3D,0,0,0,0,i.dims[1],i.dims[2],i.dims[3],e.RGBA_INTEGER,e.UNSIGNED_BYTE,r),{orientShader:m,outTexture:p,paqdTexture:g}}function Ze(t,e){if(typeof e=="number")return e>=t.length?-1:e;for(let i=0;i<t.length;i++)if(t[i].id===e)return i;return-1}function Vf(t,e){const i=[...t,e],r=i.length===1?0:i.length-1;return{meshes:i,index:r}}function Pf(t,e,i=0){const r=t.length;if(i>r)return{meshes:t};const s=Ze(t,e.id);if(s<0)return{meshes:t};const n=[...t];return i===0?(n.splice(s,1),n.unshift(e)):i<0?n.splice(s,1):(n.splice(s,1),n.splice(i,0,e)),{meshes:n}}function Nf(t){const{meshes:e,id:i,key:r,val:s,gl:n}=t,a=Ze(e,i);return a<0?(F.warn("setMeshProperty() id not loaded",i),-1):(e[a].setProperty(r,s,n),a)}function Lf(t){const{meshes:e,meshId:i,Xmm:r,Ymm:s,Zmm:n}=t,a=Ze(e,i);return a<0?(F.warn("indexNearestXYZmm() id not loaded",i),[NaN,NaN]):e[a].indexNearestXYZmm(r,s,n)}function kf(t){const{meshes:e,meshId:i,gl:r,order:s=3}=t,n=Ze(e,i);return n<0?(F.warn("decimateHierarchicalMesh() id not loaded",i),!1):e[n].decimateHierarchicalMesh(r,s)}function Of(t){const{meshes:e,meshId:i,gl:r}=t,s=Ze(e,i);return s<0?(F.warn("reverseFaces() id not loaded",i),!1):(e[s].reverseFaces(r),!0)}async function zf(t){const{meshes:e,meshId:i,layer:r,key:s,val:n,gl:a}=t,o=Ze(e,i);return o<0?(F.warn("setMeshLayerProperty() id not loaded",i),!1):(await e[o].setLayerProperty(r,s,n,a),!0)}function Gf(t){const{meshes:e,meshShaders:i,id:r,meshShaderNameOrNumber:s,meshShaderNameToNumber:n}=t;let a=0;if(typeof s=="number"?a=s:a=n(s),a===void 0)throw new Error("shaderIndex undefined");a=Math.min(a,i.length-1),a=Math.max(a,0);const o=Ze(e,r);return o>=e.length||o<0?(F.debug("Unable to change shader until mesh is loaded (maybe you need async)"),null):(e[o].meshShaderIndex=a,{meshIndex:o,shaderIndex:a})}var Qt={name:"untitled connectome",nodeColormap:"warm",nodeColormapNegative:"winter",nodeMinColor:0,nodeMaxColor:4,nodeScale:3,edgeColormap:"warm",edgeColormapNegative:"winter",edgeMin:2,edgeMax:6,edgeScale:1,legendLineThickness:0,showLegend:!0},ci=class Qn extends mt{constructor(e,i){super(new Float32Array([]),new Uint32Array([]),i.name,new Uint8Array([]),1,!0,e,i),D(this,"gl"),D(this,"nodesChanged"),this.gl=e,this.type="connectome",this.nodes&&this.updateLabels(),this.nodesChanged=new EventTarget}static convertLegacyConnectome(e){const i={nodes:[],edges:[],...Qt};for(const s in e)if(s in Qt){const n=s;i[n]=e[n]}const r=e.nodes;for(let s=0;s<r.names.length;s++)i.nodes.push({name:r.names[s],x:r.X[s],y:r.Y[s],z:r.Z[s],colorValue:r.Color[s],sizeValue:r.Size[s]});for(let s=0;s<r.names.length-1;s++)for(let n=s+1;n<r.names.length;n++){const a=e.edges[s*r.names.length+n];i.edges.push({first:s,second:n,colorValue:a})}return i}static convertFreeSurferConnectome(e,i="warm"){let r=!0;if("data_type"in e?e.data_type!=="fs_pointset"&&(r=!1):r=!1,"points"in e||(r=!1),!r)throw Error("not a valid FreeSurfer json pointset");const s=e.points.map(a=>({name:Array.isArray(a.comments)&&a.comments.length>0&&"text"in a.comments[0]?a.comments[0].text:"",x:a.coordinates.x,y:a.coordinates.y,z:a.coordinates.z,colorValue:1,sizeValue:1,metadata:a.comments}));return{...Qt,nodeColormap:i,edgeColormap:i,nodes:s,edges:[]}}updateLabels(){const e=this.nodes;if(e&&e.length>0){const i=e.reduce((c,h)=>c.sizeValue>h.sizeValue?c:h).sizeValue;let r,s;if(typeof this.nodeMinColor<"u"&&isFinite(this.nodeMinColor))r=this.nodeMinColor;else{r=e[0].colorValue;for(let c=1;c<e.length;c++)e[c].colorValue<r&&(r=e[c].colorValue)}if(typeof this.nodeMaxColor<"u"&&isFinite(this.nodeMaxColor))s=this.nodeMaxColor;else{s=e[0].colorValue;for(let c=1;c<e.length;c++)e[c].colorValue>s&&(s=e[c].colorValue)}const n=re.colormap(this.nodeColormap,this.colormapInvert),a=re.colormap(this.nodeColormapNegative,this.colormapInvert),o="nodeColormapNegative"in this;let l=this.legendLineThickness?this.legendLineThickness:0;this.showLegend===!1&&(l=0);for(let c=0;c<e.length;c++){let h=e[c].colorValue,d=!1;if(o&&h<0&&(d=!0,h=-h),r<s){if(h<r){F.warn("color value lower than min");continue}h=(h-r)/(s-r)}else h=1;h=Math.round(Math.max(Math.min(255,h*255)))*4;let f=[n[h],n[h+1],n[h+2],255];d&&(f=[a[h],a[h+1],a[h+2],255]),f=f.map(u=>u/255),F.debug("adding label for ",e[c]),e[c].label=new Er(e[c].name,{textColor:f,bulletScale:e[c].sizeValue/i,bulletColor:f,lineWidth:l,lineColor:f,textScale:1,textAlignment:"left",lineTerminator:"none"},[e[c].x,e[c].y,e[c].z]),F.debug("label for node:",e[c].label)}}}addConnectomeNode(e){if(F.debug("adding node",e),!this.nodes)throw new Error("nodes not defined");this.nodes.push(e),this.updateLabels(),this.nodesChanged.dispatchEvent(new CustomEvent("nodeAdded",{detail:{node:e}}))}deleteConnectomeNode(e){const i=this.nodes.indexOf(e),r=this.edges;r&&(this.edges=r.filter(s=>s.first!==i&&s.second!==i)),this.nodes=this.nodes.filter(s=>s!==e),this.updateLabels(),this.updateConnectome(this.gl),this.nodesChanged.dispatchEvent(new CustomEvent("nodeDeleted",{detail:{node:e}}))}updateConnectomeNodeByIndex(e,i){this.nodes[e]=i,this.updateLabels(),this.updateConnectome(this.gl),this.nodesChanged.dispatchEvent(new CustomEvent("nodeChanged",{detail:{node:i}}))}updateConnectomeNodeByPoint(e,i){const r=this.nodes;if(!r)throw new Error("Node to update does not exist");const s=r.find(a=>H.arraysAreEqual([a.x,a.y,a.z],e));if(!s)throw new Error(`Node with point ${e} to update does not exist`);const n=r.findIndex(a=>a===s);this.updateConnectomeNodeByIndex(n,i)}addConnectomeEdge(e,i,r){const s=this.edges;let n=s.find(a=>(a.first===e||a.second===e)&&a.first+a.second===e+i);return n||(n={first:e,second:i,colorValue:r},s.push(n),this.updateConnectome(this.gl),n)}deleteConnectomeEdge(e,i){const r=this.edges,s=r.find(n=>(n.first===e||n.first===i)&&n.first+n.second===e+i);if(s)this.edges=r.filter(n=>n!==s);else throw new Error(`edge between ${e} and ${i} not found`);return this.updateConnectome(this.gl),s}findClosestConnectomeNode(e,i){const r=this.nodes;if(!r||r.length===0)return null;const s=r.map((n,a)=>({node:n,distance:Math.sqrt(Math.pow(n.x-e[0],2)+Math.pow(n.y-e[1],2)+Math.pow(n.z-e[2],2)),index:a})).filter(n=>n.distance<i).sort((n,a)=>n.distance-a.distance);return s.length>0?s[0].node:null}updateConnectome(e){const i=[],r=[],s=[];let n=re.colormap(this.nodeColormap,this.colormapInvert),a=re.colormap(this.nodeColormapNegative,this.colormapInvert),o="nodeColormapNegative"in this;this.nodeMinColor===void 0&&(this.nodeMinColor=NaN),this.nodeMaxColor===void 0&&(this.nodeMaxColor=NaN),this.edgeMin===void 0&&(this.edgeMin=NaN),this.edgeMax===void 0&&(this.edgeMax=NaN);let l=this.nodeMinColor,c=this.nodeMaxColor;if(!isFinite(l)||!isFinite(l)){const x=this.nodes;l=x[0].colorValue,c=x[0].colorValue;for(let A=0;A<x.length;A++)l=Math.min(l,x[A].colorValue),c=Math.max(c,x[A].colorValue)}const h=this.nodes,d=h.length;for(let x=0;x<d;x++){const A=h[x].sizeValue*this.nodeScale;if(A<=0)continue;let y=h[x].colorValue,v=!1;if(o&&y<0&&(v=!0,y=-y),l<c){if(y<l)continue;y=(y-l)/(c-l)}else y=1;y=Math.round(Math.max(Math.min(255,y*255)))*4;let b=[n[y],n[y+1],n[y+2],255];v&&(b=[a[y],a[y+1],a[y+2],255]);const w=k(h[x].x,h[x].y,h[x].z);st.makeColoredSphere(r,i,s,A,w,b)}n=re.colormap(this.edgeColormap,this.colormapInvert),a=re.colormap(this.edgeColormapNegative,this.colormapInvert),o="edgeColormapNegative"in this;const f=this.edges;if(f!==void 0&&f.length>0){if(l=this.edgeMin,c=this.edgeMax,!isFinite(l)||!isFinite(l)){l=f[0].colorValue,c=f[0].colorValue;for(let x=0;x<f.length;x++)l=Math.min(l,f[x].colorValue),c=Math.max(c,f[x].colorValue)}for(const x of f){let A=x.colorValue;const y=o&&A<0;y&&(A=-A);const v=A*this.edgeScale;if(v<=0)continue;if(l<c){if(A<l)continue;A=(A-l)/(c-l)}else A=1;A=Math.round(Math.max(Math.min(255,A*255)))*4;let b=[n[A],n[A+1],n[A+2],255];y&&(b=[a[A],a[A+1],a[A+2],255]);const w=k(h[x.first].x,h[x.first].y,h[x.first].z),C=k(h[x.second].x,h[x.second].y,h[x.second].z);st.makeColoredCylinder(r,i,s,w,C,v,b)}}const u=new Float32Array(r),m=new Uint32Array(i),p=$e.getExtents(u);this.furthestVertexFromOrigin=p.mxDx,this.extentsMin=p.extentsMin,this.extentsMax=p.extentsMax;const g=this.generatePosNormClr(u,m,new Uint8Array(s));e.bindBuffer(e.ELEMENT_ARRAY_BUFFER,this.indexBuffer),e.bufferData(e.ELEMENT_ARRAY_BUFFER,Uint32Array.from(m),e.STATIC_DRAW),e.bindBuffer(e.ARRAY_BUFFER,this.vertexBuffer),e.bufferData(e.ARRAY_BUFFER,Float32Array.from(g),e.STATIC_DRAW),this.indexCount=i.length}updateMesh(e){this.updateConnectome(e),this.updateLabels()}json(){const e={};for(const i in this)(i in 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Kf(t){const{meshes:e,documentLabels:i}=t,a=e.filter(h=>h.type==="connectome"&&h.showLegend!==!1).flatMap(h=>h.nodes).map(h=>h.label).filter(h=>h!==void 0&&h.text!==""),o=i.filter(h=>h.anchor==null||h.anchor===0),l=new Set(a);for(const h of o)l.add(h);const c=e.filter(h=>h.type==="mesh");for(let h=0;h<c.length;h++)for(let d=0;d<c[h].layers.length;d++)if(c[h].layers[d].labels)for(let f=0;f<c[h].layers[d].labels.length;f++)l.add(c[h].layers[d].labels[f]);return Array.from(l)}var Zn={};be(Zn,{MESH_EXTENSIONS:()=>Nr,getFileExt:()=>Lr,getLoader:()=>Hf,getMediaByUrl:()=>_n,handleDragEnter:()=>ea,handleDragOver:()=>ta,isDicomExtension:()=>qf,isMeshExt:()=>jn,readDirectory:()=>$n,readFileAsDataURL:()=>Qf,registerLoader:()=>Jn,traverseFileTree:()=>kr});var Nr=["ASC","BYU","DFS","FSM","PIAL","ORIG","INFLATED","SMOOTHWM","SPHERE","WHITE","G","GEO","GII","ICO","MZ3","NV","OBJ","OFF","PLY","SRF","STL","TCK","TRACT","TRI","TRK","TT","TRX","VTK","WRL","X3D","JCON","JSON"];function Lr(t,e=!0){let i;typeof t=="object"?(i=t.fullname,e=t.upperCase??!0):i=t,F.debug("fullname: ",i);const r=/(?:\.([^.]+))?$/;let s=r.exec(i)[1];if(s=s.toUpperCase(),s==="GZ")s=r.exec(i.slice(0,-3))[1],s=s.toUpperCase();else if(s==="CBOR"){const n=s;s=r.exec(i.slice(0,-5))[1],s=s.toUpperCase(),s=`${s}.${n}`}return e?s:s.toLowerCase()}function jn(t){const e=Lr(t);return F.debug("checking mesh ext:",e),Nr.includes(e)}function _n(t,e){return[...e.entries()].filter(i=>i[1]===t).map(i=>i[0]).pop()}function Jn(t){const{loaders:e,loader:i,fileExt:r,toExt:s}=t;return{...e,[r.toUpperCase()]:{loader:i,toExt:s}}}function Hf(t,e){return t[e.toUpperCase()]}function qf(t){return t.toUpperCase()==="DCM"}async function kr(t,e="",i){return new Promise(r=>{if(t.isFile)t.file(s=>{s.fullPath=e+s.name,s._webkitRelativePath=e+s.name,i.push(s),r(i)});else if(t.isDirectory){const s=t.createReader(),n=()=>{s.readEntries(a=>{if(a.length>0){const o=a.map(l=>kr(l,e+t.name+"/",i));Promise.all(o).then(n).catch(l=>{throw l})}else 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a=e.LINEAR;!r&&s&&(a=e.NEAREST),i===0?(e.activeTexture(Zf),n?(e.texParameteri(e.TEXTURE_2D,e.TEXTURE_MIN_FILTER,a),e.texParameteri(e.TEXTURE_2D,e.TEXTURE_MAG_FILTER,a)):(e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MIN_FILTER,a),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MAG_FILTER,a))):(e.activeTexture(jf),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MIN_FILTER,a),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MAG_FILTER,a))}function Ts(t,e,i,r){let s=i.slice(),n=r.slice();return t===1&&(s=e.slice()),t===2&&(s=e.slice(),n=i.slice()),{linesH:s,linesV:n}}function Jf(t,e,i,r){let s,n;switch(t){case 0:s=e[0],n=e[1];break;case 1:s=e[0],n=e[2];break;case 2:s=e[1],n=e[2];break;default:return[i,r]}const a=s/n,o=i/r;let l,c;return a>o?(l=i,c=i/a):(c=r,l=r*a),[l,c]}var $f=33984,Or=33990,Ss=33992;function bi(t,e){const i=-e*(Math.PI/180),r=(t-90)%360*(Math.PI/180),s=[Math.cos(i)*Math.cos(r),Math.cos(i)*Math.sin(r),Math.sin(i)],n=Math.sqrt(s[0]*s[0]+s[1]*s[1]+s[2]*s[2]);return n<=0||(s[0]/=n,s[1]/=n,s[2]/=n),s}function zr(t){const{azimuth:e,elevation:i,obliqueRAS:r}=t,s=J();if(s[0]=-1,Ut(s,s,qe(270-i)),Rt(s,s,qe(e-180)),r){const n=de(r);Ye(s,s,n)}return s}function ia(t){const{azimuth:e,elevation:i,obliqueRAS:r}=t,s=k(0,0,-1),n=zr({azimuth:e,elevation:i,obliqueRAS:r}),a=He(1,0,0,0,-1,0,0,0,-1),o=se();qr(o,s,a);const l=qi();wa(l,n);const c=qi();if(!ya(c,l))return k(0,0,1);const h=se();qr(h,o,c),Ie(h,h);const d=5e-5;for(let f=0;f<3;f++)Math.abs(h[f])<d&&(h[f]=Math.sign(h[f])*d||d);return h}function Es(t){const{gl:e,hdr:i,genericVAO:r,unusedVAO:s,volumeTexture:n,paqdTexture:a,gradientOrder:o,blurShader:l,gradientPrePassShader:c,sobelFirstOrderShader:h,sobelSecondOrderShader:d,rgbaTex:f}=t;let{gradientTexture:u}=t;e.bindVertexArray(r);const m=e.createFramebuffer();e.bindFramebuffer(e.FRAMEBUFFER,m),e.viewport(0,0,i.dims[1],i.dims[2]),e.disable(e.BLEND);const p=f(null,Ss,i.dims,!0),g=o===2?c:l;g.use(e),e.activeTexture($f),e.bindTexture(e.TEXTURE_3D,n),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MIN_FILTER,e.LINEAR),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MAG_FILTER,e.LINEAR);const x=.7;e.uniform1i(g.uniforms.intensityVol,0),e.uniform1f(g.uniforms.dX,x/i.dims[1]),e.uniform1f(g.uniforms.dY,x/i.dims[2]),e.uniform1f(g.uniforms.dZ,x/i.dims[3]),g.uniforms.kernelRadius&&e.uniform1i(g.uniforms.kernelRadius,0),g.uniforms.binarize&&e.uniform1i(g.uniforms.binarize,0);for(let v=0;v<i.dims[3];v++){const b=1/i.dims[3]*(v+.5);e.uniform1f(g.uniforms.coordZ,b),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,p,0,v);const w=e.checkFramebufferStatus(e.FRAMEBUFFER);w!==e.FRAMEBUFFER_COMPLETE&&F.error("blur shader: ",w),e.drawArrays(e.TRIANGLE_STRIP,0,4)}const A=o===2?d:h;A.use(e),e.activeTexture(Ss),e.bindTexture(e.TEXTURE_3D,p),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MIN_FILTER,e.LINEAR),e.texParameteri(e.TEXTURE_3D,e.TEXTURE_MAG_FILTER,e.LINEAR),e.uniform1i(A.uniforms.intensityVol,8);const y=.7;e.uniform1f(A.uniforms.dX,y/i.dims[1]),e.uniform1f(A.uniforms.dY,y/i.dims[2]),e.uniform1f(A.uniforms.dZ,y/i.dims[3]),o===2&&(e.uniform1f(A.uniforms.dX2,2*y/i.dims[1]),e.uniform1f(A.uniforms.dY2,2*y/i.dims[2]),e.uniform1f(A.uniforms.dZ2,2*y/i.dims[3])),e.uniform1f(A.uniforms.coordZ,.5),u!==null&&e.deleteTexture(u),u=f(u,Or,i.dims);for(let v=0;v<i.dims[3];v++){const b=1/i.dims[3]*(v+.5);e.uniform1f(A.uniforms.coordZ,b),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,u,0,v);const w=e.checkFramebufferStatus(e.FRAMEBUFFER);w!==e.FRAMEBUFFER_COMPLETE&&F.error("sobel shader: ",w),e.drawArrays(e.TRIANGLE_STRIP,0,4)}return e.deleteFramebuffer(m),e.deleteTexture(p),e.bindFramebuffer(e.FRAMEBUFFER,null),e.activeTexture(33992),e.bindTexture(e.TEXTURE_3D,a),e.bindVertexArray(s),u}function eu(t){const{gl:e,gradientTexture:i,dims:r}=t;if(!i||!r)return null;const s=r[1],n=r[2],a=r[3],o=s*n*a,l=e.createFramebuffer();e.bindFramebuffer(e.FRAMEBUFFER,l);const c=new Float32Array(o*4);try{for(let h=0;h<a;h++){e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,i,0,h);const d=e.checkFramebufferStatus(e.FRAMEBUFFER);if(d!==e.FRAMEBUFFER_COMPLETE){console.warn("Framebuffer not complete for gradient texture reading, slice",h,"status:",d.toString(16));continue}try{const f=new Uint8Array(s*n*4);e.readPixels(0,0,s,n,e.RGBA,e.UNSIGNED_BYTE,f);const u=new Float32Array(s*n*4);for(let p=0;p<f.length;p++)u[p]=f[p]/127.5-1;const m=h*s*n*4;c.set(u,m)}catch(f){console.warn("Failed to read pixels for slice",h,":",f);const u=h*s*n*4,m=new Float32Array(s*n*4);c.set(m,u)}}}catch(h){return console.error("Error reading gradient 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p(){if(f===u)return null;const x=d[f],A=d[f+1];return f=(f+2)%d.length,[x,A]}for(let x=a;x<=l;x++)m(x,o),m(x,c);for(let x=o+1;x<=c-1;x++)m(a,x),m(l,x);let g;for(;(g=p())!==null;){const[x,A]=g;m(x-1,A),m(x+1,A),m(x,A-1),m(x,A+1)}}function ks(t,e,i,r,s){const n=Math.abs(i[0]-r[0]),a=Math.abs(i[1]-r[1]);t[i[0]+i[1]*e[0]]=s,t[r[0]+r[1]*e[0]]=s;const o=r[0]>i[0]?1:-1,l=r[1]>i[1]?1:-1;let c=i[0],h=i[1];const d=r[0],f=r[1];if(n>=a){let u=2*a-n;for(;c!==d;)c+=o,u>=0&&(h+=l,u-=2*n),u+=2*a,t[c+h*e[0]]=s}else{let u=2*n-a;for(;h!==f;)h+=l,u>=0&&(c+=o,u-=2*a),u+=2*n,t[c+h*e[0]]=s}}function Os(t,e){const i=Math.min(Math.max(t[0],0),e[0]-1),r=Math.min(Math.max(t[1],0),e[1]-1);return[i,r]}function q2(t){let e=0,i=1;return t===1?i=2:t===2&&(e=1,i=2),[e,i]}function Q2(t){const{penFillPts:e,penAxCorSag:i,drawBitmap:r,dims:s,penValue:n,fillOverwrites:a,currentUndoBitmap:o}=t,l=e.length;if(l<2)return{drawBitmap:r,success:!1};const[c,h]=q2(i),d=[s[c+1],s[h+1]],f=new 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fa(t){const{ptA:e,ptB:i,dims:r}=t,s=r[1],n=r[2],a=r[3],o=Math.min(Math.max(Math.min(e[0],i[0]),0),s-1),l=Math.min(Math.max(Math.min(e[1],i[1]),0),n-1),c=Math.min(Math.max(Math.min(e[2],i[2]),0),a-1),h=Math.min(Math.max(Math.max(e[0],i[0]),0),s-1),d=Math.min(Math.max(Math.max(e[1],i[1]),0),n-1),f=Math.min(Math.max(Math.max(e[2],i[2]),0),a-1);return{x1:o,y1:l,z1:c,x2:h,y2:d,z2:f}}function Z2(t){const{x1:e,y1:i,z1:r,x2:s,y2:n,z2:a}=t,o=(e+s)/2,l=(i+n)/2,c=(r+a)/2,h=Math.abs(s-e)/2,d=Math.abs(n-i)/2,f=Math.abs(a-r)/2;return{centerX:o,centerY:l,centerZ:c,radiusX:h,radiusY:d,radiusZ:f}}function j2(t,e,i,r){const{centerX:s,centerY:n,centerZ:a,radiusX:o,radiusY:l,radiusZ:c}=r,h=(t-s)/(o+.5),d=(e-n)/(l+.5),f=(i-a)/(c+.5);return h*h+d*d+f*f<=1}function _2(t){const{ptA:e,ptB:i,penValue:r,drawBitmap:s,dims:n,penSize:a,penAxCorSag:o}=t,l=fa({ptA:e,ptB:i,dims:n}),{x1:c,y1:h,z1:d,x2:f,y2:u,z2:m}=l,p={x:0,y:0,z:0,penValue:r,drawBitmap:s,dims:n,penSize:a,penAxCorSag:o};for(let g=d;g<=m;g++)for(let x=h;x<=u;x++)for(let A=c;A<=f;A++)p.x=A,p.y=x,p.z=g,gt(p)}function J2(t){const{ptA:e,ptB:i,penValue:r,drawBitmap:s,dims:n,penSize:a,penAxCorSag:o}=t,l=fa({ptA:e,ptB:i,dims:n}),{x1:c,y1:h,z1:d,x2:f,y2:u,z2:m}=l,p=Z2(l),g={x:0,y:0,z:0,penValue:r,drawBitmap:s,dims:n,penSize:a,penAxCorSag:o};for(let x=d;x<=m;x++)for(let A=h;A<=u;A++)for(let y=c;y<=f;y++)j2(y,A,x,p)&&(g.x=y,g.y=A,g.z=x,gt(g))}function $2(t,e,i){return t[0]+t[1]*e+t[2]*i}function em(t,e,i){const r=Math.floor(t/i),s=Math.floor((t-r*i)/e);return[Math.floor(t%e),s,r]}function ua(t){const e=t[0],i=e*t[1],r=i*t[2];return{xyz2vx:s=>$2(s,e,i),vx2xyz:s=>em(s,e,i),nx:e,nxy:i,nxyz:r}}function tm(t,e){return t?e===0?2:e===1?1:e===2?0:-1:-1}var Hi={face:[[0,0,-1],[0,0,1],[0,-1,0],[0,1,0],[-1,0,0],[1,0,0]],edge:[[-1,-1,0],[1,-1,0],[-1,1,0],[1,1,0],[0,-1,-1],[0,1,-1],[-1,0,-1],[1,0,-1],[0,-1,1],[0,1,1],[-1,0,1],[1,0,1]],corner:[[-1,-1,-1],[1,-1,-1],[-1,1,-1],[1,1,-1],[-1,-1,1],[1,-1,1],[-1,1,1],[1,1,1]]};function im(t){const{img:e,seedVx:i,dims:r,neighbors:s=6}=t,n=ua(r),a=[];a.push(i),e[i]=2;const o=[...Hi.face];for(s>=18&&o.push(...Hi.edge),s>=26&&o.push(...Hi.corner);a.length>0;){const l=a.shift(),c=n.vx2xyz(l);for(const h of o){const d=[c[0]+h[0],c[1]+h[1],c[2]+h[2]];if(d[0]<0||d[1]<0||d[2]<0||d[0]>=r[0]||d[1]>=r[1]||d[2]>=r[2])continue;const f=n.xyz2vx(d);e[f]===1&&(e[f]=2,a.push(f))}}}function rm(t){const{voxelIntensity:e,thresholdPercent:i,calMin:r,calMax:s,autoIntensity:n,currentIntensityMin:a,currentIntensityMax:o,currentBright:l}=t;let c=a,h=o,d=l;if(n){if(i!==0){const f=e===0?.01:e;h=f*(1+i),c=f*(1-i)}d=e>(r+s)*.5}return{intensityMin:c,intensityMax:h,isBright:d}}function sm(t){return t?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY}function nm(t){const{sourceBitmap:e,targetBitmap:i}=t;if(!e||!i||e.length!==i.length)return!1;const r=i.length;for(let s=0;s<r;s++)i[s]=e[s];return!0}function am(t){let e=0;for(let i=0;i<t.length;i++)e+=t[i];return e}function om(t){const{clusterImg:e,backImg:i,nxyz:r,fallbackIntensity:s}=t;let n=0,a=0;for(let o=0;o<r;o++)e[o]===2&&(n+=i[o],a++);return a>0?n/a:s}function zs(t,e,i,r){return isFinite(i)&&isFinite(r)?[i,r]:t===Number.POSITIVE_INFINITY?[e,1/0]:t===Number.NEGATIVE_INFINITY?[-1/0,e]:[-1/0,1/0]}function lm(t,e){return!(t[0]<0||t[1]<0||t[2]<0||t[0]>=e[0]||t[1]>=e[1]||t[2]>=e[2])}function cm(t){return t!==0}function hm(t,e,i,r){return i&&r!==0?t!==0:t!==0||e===0}function dm(t){const{img:e,targetBitmap:i,originalBitmap:r,newColor:s,nxyz:n,isPreviewMode:a}=t;let o=0;for(let l=0;l<n;l++)e[l]===2?(i[l]=s,o++):a&&(i[l]=r[l]);return o}function fm(t){const{img:e,dims:i}=t,r=i[1]*i[2]*i[3],s=new Uint8Array(r);for(let n=0;n<r;n++)e[n]!==0&&(s[n]=1);return{img:s,datatypeCode:2,cal_min:0,cal_max:1}}function um(t){const{img:e,cal_min:i,cal_max:r,scl_inter:s,scl_slope:n,mlevel:a=2}=t,o=e.length;if(o<1)return[];const l=256,c=l-1,h=new Array(l).fill(0),d=i,f=r;if(f<=d)return[];const u=(f-d)/l;function m(v){return 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mm(t){const{img:e,drawBitmap:i,thresholds:r}=t,s=e.length,n=new Uint8Array(i);for(let a=0;a<s;a++){if(n[a]!==0)continue;const o=e[a];o>r[0]&&(n[a]=1),o>r[1]&&(n[a]=2),o>r[2]&&(n[a]=3)}return n}function pm(t){const{level:e}=t;return e===5||e===1?4:e===4||e===2?3:2}function gm(t){const{level:e,thresholds:i}=t;return e===1?i[2]:e===2?i[1]:i[0]}function Am(t){const{img:e,scl_inter:i,scl_slope:r,global_min:s,threshold:n}=t,a=e.length;for(let o=0;o<a;o++)e[o]*r+i<n&&(e[o]=s)}function pe(t,e,i,r){return i*r[0]*r[1]+e*r[0]+t}function Kr(t,e,i){let r=0;const s=new Uint32Array(i+5).fill(0);let a=2147483647;for(let o=0;o<i;o++){let l=e[o];for(r=0;t[l-1]!==l;)if(l=t[l-1],r++,r>100){F.info(`
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f=0;const u=t[pe(d,h,c,e)];if(u!==0){if(l[0]=ma(t,o,d,h,c,e,i,a),l[0]&&(f+=1),i>=6){if(d){const m=pe(d-1,h,c,e);u===t[m]&&(l[f++]=o[m])}if(h){const m=pe(d,h-1,c,e);u===t[m]&&(l[f++]=o[m])}}if(i>=18){if(h&&d){const m=pe(d-1,h-1,c,e);u===t[m]&&(l[f++]=o[m])}if(h&&d<e[0]-1){const m=pe(d+1,h-1,c,e);u===t[m]&&(l[f++]=o[m])}}if(f)o[pe(d,h,c,e)]=l[0],Kr(a,l,f);else{if(o[pe(d,h,c,e)]=r,r>=n){n+=s;const m=new Uint32Array(n);m.set(a),a=m}a[r-1]=r,r++}}}for(let c=0;c<r-1;c++){let h=c;for(;a[h]!==h+1;)h=a[h]-1;a[c]=h+1}return{labelCount:r-1,translationTable:a,initialLabels:o}}function ga(t,e,i,r){const s=e[0]*e[1]*e[2];let n=0;const a=new Uint32Array(s).fill(0);for(let c=0;c<r;c++)n=Math.max(n,i[c]);const o=new Uint32Array(n).fill(0);let l=0;for(let c=0;c<s;c++)t[c]&&(o[i[t[c]-1]-1]||(l+=1,o[i[t[c]-1]-1]=l),a[c]=o[i[t[c]-1]-1]);return{clusterCount:l,labels:a}}function Aa(t,e,i){const r=t.length,s=new Uint32Array(e+1).fill(0),n=new Uint32Array(e+1).fill(0);for(let l=0;l<r;l++){const c=t[l],h=i[l];s[h]=c,n[h]++}let a=0;for(let l=0;l<e+1;l++){const c=s[l];a=Math.max(a,c);for(let h=0;h<e+1;h++)h!==l&&c===s[h]&&(n[l]<n[h]||n[l]===n[h]&&l<h)&&(s[l]=0)}const o=new Uint32Array(r).fill(0);for(let l=0;l<r;l++)o[l]=s[i[l]];return{maxValue:a,voxels:o}}function xm(t){const{img:e,dim:i,conn:r=26,binarize:s=!1,onlyLargestClusterPerClass:n=!1}=t,a=Date.now(),o=i[0]*i[1]*i[2],l=new Uint32Array(o).fill(0);if(![6,18,26].includes(r))return F.info("bwlabel: conn must be 6, 18 or 26."),{clusterCount:0,labels:l};if(i[0]<2||i[1]<2||i[2]<1)return F.info("bwlabel: img must be 2 or 3-dimensional"),{clusterCount:0,labels:l};if(s)for(let m=0;m<o;m++)e[m]!==0&&(l[m]=1);else l.set(e);let{labelCount:c,translationTable:h,initialLabels:d}=pa(l,i,r);h===void 0&&(h=new Uint32Array);const{clusterCount:f,labels:u}=ga(d,i,h,c);if(F.info(r+" neighbor clustering into "+f+" regions in 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te=0;te+=e[q]*W*K*Z,te+=e[q+p]*W*K*z,te+=e[q+f]*W*_*Z,te+=e[q+f+p]*W*_*z,te+=e[q+1]*Y*K*Z,te+=e[q+1+p]*Y*K*z,te+=e[q+1+f]*Y*_*Z,te+=e[q+1+f+p]*Y*_*z,d[v]=te}}else for(let b=0;b<c;b++)for(let w=0;w<l;w++){const C=w*n[1]+b*n[2]+n[3],M=w*n[5]+b*n[6]+n[7],T=w*n[9]+b*n[10]+n[11];for(let E=0;E<o;E++){const I=Math.round(E*x+C),S=Math.round(E*A+M),U=Math.round(E*y+T);v++,!(I<0||S<0||U<0)&&(I>=f||S>=u||U>=m||(d[v]=e[g(I,S,U)]))}}return d}function Cm(t,e,i,r,s){const n=new Uint8Array(t);n.fill(0);let a=-1;if(e[0]===i[0])a=0;else if(e[1]===i[1])a=1;else if(e[2]===i[2])a=2;else return console.error("Error: No constant dimension found."),null;const l=[0,1,2].filter(w=>w!==a),c=[];c[a]=e[a],c[l[0]]=(e[l[0]]+i[l[0]])/2,c[l[1]]=(e[l[1]]+i[l[1]])/2;const 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f=Cm(e,a,o,l,c);return f?{mask:f.mask,area:f.area}:{mask:h,area:null}}return{mask:h,area:d}}function Dm(t,e){const i=t.length;let r=0,s=0,n=0,a=Number.NEGATIVE_INFINITY,o=Number.POSITIVE_INFINITY,l=0,c=0,h=0;for(let p=0;p<i;p++){if(e[p]<1)continue;const g=t[p];r++;let x=s+(g-s)/r;n=n+(g-s)*(g-x),s=x,g!==0&&(l++,x=c+(g-c)/l,h=h+(g-c)*(g-x),c=x,o=Math.min(g,o),a=Math.max(g,a))}const d=Math.sqrt(n/(r-1)),f=Math.sqrt(h/(l-1)),u=o,m=a;return r!==l&&(o=Math.min(0,o),a=Math.max(0,a)),{mean:s,stdev:d,nvox:r,min:o,max:a,meanNot0:c,stdevNot0:f,nvoxNot0:l,minNot0:u,maxNot0:m}}function Tm(t,e,i){const r=t.length,s=new Float32Array(r);for(let n=0;n<r;n++)s[n]=t[n]*e+i;return s}var Sm=class extends CustomEvent{constructor(t,e){super(t,{detail:e})}},{version:Ys}=pl,{MESH_EXTENSIONS:Zt}=Zn,{LEFT_MOUSE_BUTTON:jt,CENTER_MOUSE_BUTTON:Xs,RIGHT_MOUSE_BUTTON:Ws}=sa,Ks={filename:"",isSaveDrawing:!1,volumeByIndex:0},ft,Lm=class extends 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Date().getTime()),D(this,"selectedObjectId",-1),D(this,"CLIP_PLANE_ID",1),D(this,"VOLUME_ID",254),D(this,"DISTANCE_FROM_CAMERA",-.54),D(this,"graph",{LTWH:[0,0,640,480],opacity:0,vols:[0],autoSizeMultiplanar:!1,normalizeValues:!1,isRangeCalMinMax:!1}),D(this,"customLayout",[]),D(this,"meshShaders",Vd()),D(this,"dragModes",{contrast:1,measurement:2,angle:7,none:0,pan:3,slicer3D:4,callbackOnly:5}),D(this,"sliceTypeAxial",0),D(this,"sliceTypeCoronal",1),D(this,"sliceTypeSagittal",2),D(this,"sliceTypeMultiplanar",3),D(this,"sliceTypeRender",4),D(this,"onDragRelease",()=>{}),D(this,"onMouseUp",()=>{}),D(this,"onLocationChange",()=>{}),D(this,"onIntensityChange",()=>{}),D(this,"onClickToSegment",()=>{}),D(this,"onImageLoaded",()=>{}),D(this,"onMeshLoaded",()=>{}),D(this,"onFrameChange",()=>{}),D(this,"onError",()=>{}),D(this,"onColormapChange",()=>{}),D(this,"onInfo",()=>{}),D(this,"onWarn",()=>{}),D(this,"onDebug",()=>{}),D(this,"onVolumeAddedFromUrl",()=>{}),D(this,"onVolumeWithUrlRemoved",()=>{}),D(this,"onVolumeUpdated",()=>{}),D(this,"onMeshAddedFromUrl",()=>{}),D(this,"onMeshAdded",()=>{}),D(this,"onMeshWithUrlRemoved",()=>{}),D(this,"onZoom3DChange",()=>{}),D(this,"onAzimuthElevationChange",()=>{}),D(this,"onClipPlaneChange",()=>{}),D(this,"onCustomMeshShaderAdded",()=>{}),D(this,"onMeshShaderChanged",()=>{}),D(this,"onMeshPropertyChanged",()=>{}),D(this,"onDicomLoaderFinishedWithImages",()=>{}),D(this,"onDocumentLoaded",()=>{}),D(this,"onOptsChange",()=>{}),D(this,"onMeasurementCompleted",()=>{}),D(this,"onAngleCompleted",()=>{}),D(this,"onPenValueChanged",()=>{}),D(this,"onDrawingToolChanged",()=>{}),D(this,"onVolumeRemoved",()=>{}),D(this,"onMeshRemoved",()=>{}),D(this,"onSliceTypeChange",()=>{}),D(this,"onDrawingChanged",()=>{}),D(this,"onDrawingEnabled",()=>{}),D(this,"onVolumeOrderChanged",()=>{}),D(this,"document",new St),D(this,"mediaUrlMap",new Map),D(this,"initialized",!1),D(this,"currentDrawUndoBitmap");for(const e in t)typeof t[e]=="function"?this[e]=t[e]:this.opts[e]=ke[e]===void 0?ke[e]:t[e];this.opts.forceDevicePixelRatio===0?this.uiData.dpr=window.devicePixelRatio||1:this.opts.forceDevicePixelRatio<0?this.uiData.dpr=1:this.uiData.dpr=this.opts.forceDevicePixelRatio,this.currentDrawUndoBitmap=this.opts.maxDrawUndoBitmaps,this.opts.drawingEnabled&&this.createEmptyDrawing(),this.opts.thumbnail.length>0&&(this.thumbnailVisible=!0),F.setLogLevel(this.opts.logLevel),this.document.setOptsChangeCallback((e,i,r)=>{this._emitEvent("optsChange",{propertyName:e,newValue:i,oldValue:r}),this.onOptsChange(e,i,r)}),this.scene.onZoom3DChange=e=>{this._emitEvent("zoom3DChange",{zoom:e}),this.onZoom3DChange(e)}}get scene(){return this.document.scene}get opts(){return this.document.opts}get sliceMosaicString(){return this.document.opts.sliceMosaicString||""}set sliceMosaicString(t){this.document.opts.sliceMosaicString=t}get isAlphaClipDark(){return this.document.opts.isAlphaClipDark}set isAlphaClipDark(t){this.document.opts.isAlphaClipDark=t}addEventListener(t,e,i){super.addEventListener(t,e,i)}removeEventListener(t,e,i){super.removeEventListener(t,e,i)}_emitEvent(t,e){try{const i=new Sm(t,e);this.dispatchEvent(i)}catch(i){console.error(`Error in ${t} event listener:`,i)}}cleanup(){Ou(this.resizeObserver,this.canvasObserver,this.resizeEventListener),this.resizeEventListener=null,this.resizeObserver=null,this.canvasObserver=null,zu(X(this,ft)),Ke(this,ft,null),this.document.removeOptsChangeCallback()}get volumes(){return this.document.volumes}set volumes(t){this.document.volumes=t}get meshes(){return this.document.meshes}set meshes(t){this.document.meshes=t}get drawBitmap(){return this.document.drawBitmap}set drawBitmap(t){this.document.drawBitmap=t}get volScaleMultiplier(){return this.scene.volScaleMultiplier}set volScaleMultiplier(t){this.setScale(t)}async saveScene(t="niivue.png"){function e(r,s){const n=document.createElement("a");document.body.appendChild(n),n.style.display="none";const a=window.URL.createObjectURL(r);n.href=a,n.download=s,n.click(),n.remove()}const i=this.canvas;if(!i)throw new Error("canvas not defined");this.drawScene(),i.toBlob(r=>{r&&(t===""&&(t=`niivue-screenshot-${new Date().toString()}.png`,t=t.replace(/\s/g,"_")),e(r,t))})}async attachTo(t,e=null){return await this.attachToCanvas(document.getElementById(t),e),F.debug("attached to element with id: ",t),this}async attachToCanvas(t,e=null){this.canvas=t,e===null&&(e=navigator.hardwareConcurrency>6,F.debug("AntiAlias ",e," Threads ",navigator.hardwareConcurrency));const{gl:i,max2D:r,max3D:s}=Kc(this.canvas,e);return this.gl=i,this.uiData.max2D=r,this.uiData.max3D=s,F.info("NIIVUE VERSION ",Ys),F.debug(`Max texture size 2D: ${this.uiData.max2D} 3D: ${this.uiData.max3D}`),this.canvas.parentElement.style.backgroundColor="black",this.opts.isResizeCanvas&&(Bs(this.canvas),this.canvas.width=this.canvas.offsetWidth,this.canvas.height=this.canvas.offsetHeight,this.resizeEventListener=Pu(()=>this.resizeListener()),window.addEventListener("resize",this.resizeEventListener),this.resizeObserver=Nu(()=>this.resizeListener()),this.resizeObserver.observe(this.canvas.parentElement),this.canvasObserver=Lu(n=>{for(const a of n)if(a.type==="childList"&&a.removedNodes.length>0&&Array.from(a.removedNodes).includes(this.canvas)){this.cleanup();break}}),this.canvasObserver.observe(this.canvas.parentElement,{childList:!0})),this.opts.interactive&&this.registerInteractions(),await this.init(),this.drawScene(),this}syncWith(t,e={"2d":!0,"3d":!0}){t instanceof Array||(t=[t]),this.otherNV=t,this.syncOpts={...e}}broadcastTo(t,e={"2d":!0,"3d":!0}){t instanceof Array||(t=[t]),this.otherNV=t,this.syncOpts=e}doSync3d(t){t.scene.renderAzimuth=this.scene.renderAzimuth,t.scene.renderElevation=this.scene.renderElevation,t.scene.volScaleMultiplier=this.scene.volScaleMultiplier}doSync2d(t){const e=this.frac2mm(this.scene.crosshairPos);t.scene.crosshairPos=t.mm2frac(e),t.scene.pan2Dxyzmm=ze(this.scene.pan2Dxyzmm)}doSyncGamma(t){const e=this.scene.gamma,i=t.scene.gamma;e!==i&&t.setGamma(e)}doSyncZoomPan(t){t.scene.pan2Dxyzmm=ze(this.scene.pan2Dxyzmm)}doSyncCrosshair(t){const e=this.frac2mm(this.scene.crosshairPos);t.scene.crosshairPos=t.mm2frac(e)}doSyncCalMin(t){this.volumes[0].cal_min!==t.volumes[0].cal_min&&(t.volumes[0].cal_min=this.volumes[0].cal_min,t.updateGLVolume())}doSyncCalMax(t){this.volumes[0].cal_max!==t.volumes[0].cal_max&&(t.volumes[0].cal_max=this.volumes[0].cal_max,t.updateGLVolume())}doSyncSliceType(t){t.setSliceType(this.opts.sliceType)}doSyncClipPlane(t){t.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])}sync(){if(!(!this.gl||!this.otherNV||typeof this.otherNV>"u")&&this.gl.canvas.matches(":focus"))for(let t=0;t<this.otherNV.length;t++)this.otherNV[t]!==this&&(this.syncOpts.gamma&&this.doSyncGamma(this.otherNV[t]),this.syncOpts.crosshair&&this.doSyncCrosshair(this.otherNV[t]),this.syncOpts.zoomPan&&this.doSyncZoomPan(this.otherNV[t]),this.syncOpts.sliceType&&this.doSyncSliceType(this.otherNV[t]),this.syncOpts.cal_min&&this.doSyncCalMin(this.otherNV[t]),this.syncOpts.cal_max&&this.doSyncCalMax(this.otherNV[t]),this.syncOpts.clipPlane&&this.doSyncClipPlane(this.otherNV[t]),this.syncOpts["2d"]&&this.doSync2d(this.otherNV[t]),this.syncOpts["3d"]&&this.doSync3d(this.otherNV[t]),this.otherNV[t].canvas!==this.canvas&&this.otherNV[t].drawScene(),this.otherNV[t].createOnLocationChange())}arrayEquals(t,e){return Array.isArray(t)&&Array.isArray(e)&&t.length===e.length&&t.every((i,r)=>i===e[r])}textSizePoints(){this.opts.textHeight>=0&&(F.warn("textHeight is deprecated (use fontMinPx and fontSizeScaling)"),this.opts.fontMinPx=this.opts.textHeight*217,this.opts.fontSizeScaling=.4,this.opts.textHeight=-1);const t=this.uiData.dpr||1,e=this.opts.fontMinPx,i=this.gl.canvas.width/t,r=this.gl.canvas.height/t,s=i*r,n=800*600,a=Math.max(s/n,1),o=Math.pow(a,this.opts.fontSizeScaling),l=e*o*t;this.fontPx=l,F.debug(`${i.toFixed(0)}x${r.toFixed(0)} pts (dpi=${t}) => areaScale=${a.toFixed(2)}, scale=${o.toFixed(2)}, minPx=${this.opts.fontMinPx} fontScale=${this.opts.fontSizeScaling} fontPx=${l.toFixed(2)}`)}resizeListener(){if(!ku(this.canvas,this._gl))return;if(!this.opts.isResizeCanvas){this.opts.forceDevicePixelRatio>=0&&F.warn("this.opts.forceDevicePixelRatio requires isResizeCanvas"),this.drawScene();return}Bs(this.canvas);const t=Vu({canvas:this.canvas,gl:this.gl,isResizeCanvas:this.opts.isResizeCanvas,forceDevicePixelRatio:this.opts.forceDevicePixelRatio});this.uiData.dpr=t.dpr,F.debug("devicePixelRatio: "+this.uiData.dpr),this.canvas.width=t.width,this.canvas.height=t.height,this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.textSizePoints(),this.drawScene()}getRelativeMousePosition(t,e){return ra(t,e)}getNoPaddingNoBorderCanvasRelativeMousePosition(t,e){return Uu(t,e)}mouseContextMenuListener(t){t.preventDefault()}mouseDownListener(t){if(this.uiData.mousedown=!0,this.eventInBounds(t))this.opts.bounds&&(this.opts.showBoundsBorder=!0);else{this.opts.showBoundsBorder=!1,this.drawScene();return}t.preventDefault(),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawShapeStartLocation=[NaN,NaN,NaN];const e=this.getNoPaddingNoBorderCanvasRelativeMousePosition(t,this.gl.canvas);if(this.opts.dragMode===7&&this.uiData.angleState==="drawing_second_line"||(this.setDragStart(e.x,e.y),this.setDragEnd(e.x,e.y)),F.debug("mouse down"),F.debug(t),!e)return;const[i,r]=[e.x*this.uiData.dpr,e.y*this.uiData.dpr];this.opts.clickToSegment&&(this.clickToSegmentXY=[i,r]);const s=this.getLabelAtPoint([i,r]);if(s){if(s.onClick){s.onClick(s,t);return}for(const n of this.meshes){if(n.type!=="connectome"){if(Array.isArray(s.points)&&s.points.length===3&&s.points.every(Number.isFinite)){const[a,o,l]=s.points;this.scene.crosshairPos=this.mm2frac([a,o,l]),this.updateGLVolume()}continue}for(const a of n.nodes)a.label===s&&(this.scene.crosshairPos=this.mm2frac([a.x,a.y,a.z]),this.updateGLVolume())}}this.uiData.clickedTile=this.tileIndex(i,r),t.button===jt&&t.shiftKey?(this.uiData.mouseButtonCenterDown=!0,this.setActiveDragMode(jt,!0,t.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,t,e)):t.button===jt?(this.uiData.mouseButtonLeftDown=!0,this.setActiveDragMode(jt,!1,t.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,t,e)):t.button===Ws?(this.uiData.mouseButtonRightDown=!0,this.setActiveDragMode(Ws,t.shiftKey,t.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,t,e)):t.button===Xs&&(this.uiData.mouseButtonCenterDown=!0,this.setActiveDragMode(Xs,t.shiftKey,t.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,t,e)),this.drawScene()}getMouseButtonDragMode(t,e,i){return na({button:t,shiftKey:e,ctrlKey:i,mouseConfig:this.opts.mouseEventConfig,dragMode:this.opts.dragMode,dragModePrimary:this.opts.dragModePrimary})}getTouchDragMode(t){return Qu({isDoubleTouch:t,touchConfig:this.opts.touchEventConfig,dragMode:this.opts.dragMode,dragModePrimary:this.opts.dragModePrimary})}setActiveDragMode(t,e,i){const r=this.getMouseButtonDragMode(t,e,i),s=E1(r,t);this.uiData.activeDragMode=s.activeDragMode,this.uiData.activeDragButton=s.activeDragButton}getCurrentDragMode(){return T1({activeDragMode:this.uiData.activeDragMode,fallbackDragMode:this.opts.dragMode})}clearActiveDragMode(){const t=S1();this.uiData.activeDragMode=t.activeDragMode,this.uiData.activeDragButton=t.activeDragButton}handleMouseAction(t,e,i){if(t===8)this.mouseDown(i.x,i.y),this.mouseClick(i.x,i.y);else if(t===9)this.uiData.windowX=i.x,this.uiData.windowY=i.y;else{if(this.mousePos=[i.x*this.uiData.dpr,i.y*this.uiData.dpr],t===0)return;if(t===7)if(this.uiData.angleState==="none")this.uiData.angleState="drawing_first_line";else if(this.uiData.angleState==="drawing_second_line"){const r=[i.x*this.uiData.dpr,i.y*this.uiData.dpr],s=this.tileIndex(r[0],r[1]);let n={sliceIndex:-1,sliceType:0,slicePosition:0};if(s>=0&&s<this.screenSlices.length){const d=this.screenSlices[s].axCorSag;let f=0;d===0?f=this.scene.crosshairPos[2]:d===1?f=this.scene.crosshairPos[1]:d===2&&(f=this.scene.crosshairPos[0]),n={sliceIndex:s,sliceType:d,slicePosition:f}}const a=[this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],r[0],r[1]],o=this.canvasPos2frac([this.uiData.angleFirstLine[0],this.uiData.angleFirstLine[1]]),l=this.canvasPos2frac([this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3]]),c=this.canvasPos2frac([a[0],a[1]]),h=this.canvasPos2frac([a[2],a[3]]);if(o[0]>=0&&l[0]>=0&&c[0]>=0&&h[0]>=0){const d=this.frac2mm(o),f=this.frac2mm(l),u=this.frac2mm(c),m=this.frac2mm(h),p={firstLineMM:{start:k(d[0],d[1],d[2]),end:k(f[0],f[1],f[2])},secondLineMM:{start:k(u[0],u[1],u[2]),end:k(m[0],m[1],m[2])},sliceIndex:n.sliceIndex,sliceType:n.sliceType,slicePosition:n.slicePosition,angle:this.calculateAngleBetweenLines(this.uiData.angleFirstLine,a)};this.document.completedAngles.push(p),this._emitEvent("angleCompleted",p),this.onAngleCompleted(p)}this.resetAngleMeasurement(),this.uiData.angleState="complete",this.drawScene();return}else this.uiData.angleState==="complete"&&(this.resetAngleMeasurement(),this.uiData.angleState="drawing_first_line");if(this.setDragStart(i.x,i.y),!this.uiData.isDragging){this.uiData.pan2DxyzmmAtMouseDown=ze(this.scene.pan2Dxyzmm);for(const r of this.getZarrVolumes())r.zarrHelper?.beginDrag()}this.uiData.isDragging=!0,this.uiData.dragClipPlaneStartDepthAziElev=this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]}}calculateMinMaxVoxIdx(t){return I1(t)}calculateNewRange({volIdx:t=0}={}){if(this.opts.sliceType===4&&this.sliceMosaicString.length<1||!dr(this.uiData.dragStart,this.uiData.dragEnd))return;let e=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]);if(e[0]<0)return;const i=this.frac2vox(e,t);if(e=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]),e[0]<0)return;const r=this.frac2vox(e,t),s=this.calculateMinMaxVoxIdx([i[0],r[0]]),n=this.calculateMinMaxVoxIdx([i[1],r[1]]),a=this.calculateMinMaxVoxIdx([i[2],r[2]]),o=N1(i,r,s,n,a),l=this.volumes[t].hdr,c=this.volumes[t].img;if(!l||!c)return;const h=P1({xrange:o.xrange,yrange:o.yrange,zrange:o.zrange,dims:l.dims,img:c});if(!h.hasVariation)return;const d=ws(l,h.lo),f=ws(l,h.hi);this.volumes[t].cal_min=d,this.volumes[t].cal_max=f,this._emitEvent("intensityChange",this.volumes[t]),this.onIntensityChange(this.volumes[t])}generateMouseUpCallback(t,e){const i=this.tileIndex(this.uiData.dragStart[0],this.uiData.dragStart[1]),r=this.tileIndex(this.uiData.dragEnd[0],this.uiData.dragEnd[1]);let s=-1;i===r&&(s=r);let n=-1;s>=0&&(n=this.screenSlices[s].axCorSag);const a=this.frac2mm(t),o=this.frac2mm(e),l=se();Qr(l,k(a[0],a[1],a[2]),k(o[0],o[1],o[2]));const c=Vt(l),h=this.frac2vox(t),d=this.frac2vox(e),f={fracStart:t,fracEnd:e,voxStart:h,voxEnd:d,mmStart:a,mmEnd:o,mmLength:c,tileIdx:s,axCorSag:n};this._emitEvent("dragRelease",f),this.onDragRelease(f)}mouseUpListener(){this.uiData.mousedown=!1;const t={mouseButtonRightDown:this.uiData.mouseButtonRightDown,mouseButtonCenterDown:this.uiData.mouseButtonCenterDown,isDragging:this.uiData.isDragging,mousePos:this.mousePos,fracPos:this.canvasPos2frac(this.mousePos)};this.uiData.mouseButtonRightDown=!1;const e=this.uiData.mouseButtonCenterDown;this.uiData.mouseButtonCenterDown=!1,this.uiData.mouseButtonLeftDown=!1;const i=this.getCurrentDragMode();if(this.drawPenFillPts.length>0?this.drawPenFilled():this.opts.drawingEnabled&&!isNaN(this.drawPenLocation[0])?(this.drawAddUndoBitmap(),this._emitEvent("drawingChanged",{action:"draw"}),this.onDrawingChanged("draw")):this.opts.drawingEnabled&&!isNaN(this.drawShapeStartLocation[0])&&(this.opts.penType===1||this.opts.penType===2)&&(this.opts.penValue===0?this.drawAddUndoBitmap():this.drawAddUndoBitmap(this.drawFillOverwrites),this.drawShapePreviewBitmap=null,this._emitEvent("drawingChanged",{action:"draw"}),this.onDrawingChanged("draw")),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawShapeStartLocation=[NaN,NaN,NaN],this.drawShapePreviewBitmap&&(this.drawBitmap=this.drawShapePreviewBitmap,this.drawShapePreviewBitmap=null,this.refreshDrawing(!0,!1)),this._emitEvent("mouseUp",t),ca(this.onMouseUp)&&this.onMouseUp(t),this.uiData.isDragging){this.uiData.isDragging=!1;for(const n of this.getZarrVolumes())n.zarrHelper?.endDrag();if(i===7){if(this.uiData.angleState==="drawing_first_line"){this.uiData.angleFirstLine=[this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],this.uiData.angleState="drawing_second_line",this.uiData.isDragging=!0,this.drawScene();return}if(this.uiData.angleState==="drawing_second_line"){this.uiData.angleState="complete",this.clearActiveDragMode(),this.drawScene();return}}i===5&&this.drawScene();const r=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),s=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);if(this.generateMouseUpCallback(r,s),i===6){this.clearActiveDragMode();return}if(i===1){if(e){this.clearActiveDragMode();return}if(!dr(this.uiData.dragStart,this.uiData.dragEnd)){this.clearActiveDragMode();return}this.calculateNewRange({volIdx:0}),this.refreshLayers(this.volumes[0],0)}if(i===2){const n=this.getCurrentSliceInfo(),a=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),o=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);if(a[0]>=0&&o[0]>=0){const l=this.frac2mm(a),c=this.frac2mm(o),h={startMM:k(l[0],l[1],l[2]),endMM:k(c[0],c[1],c[2]),sliceIndex:n.sliceIndex,sliceType:n.sliceType,slicePosition:n.slicePosition,distance:Ea(k(l[0],l[1],l[2]),k(c[0],c[1],c[2]))};this.document.completedMeasurements.push(h),this._emitEvent("measurementCompleted",h),this.onMeasurementCompleted(h)}this.clearActiveDragMode(),this.drawScene();return}}this.clearActiveDragMode(),this.drawScene()}checkMultitouch(t){if(r1({touchdown:this.uiData.touchdown,multiTouchGesture:this.uiData.multiTouchGesture})){const e=this.canvas.getBoundingClientRect(),i=Oi({touch:t.touches[0],canvasRect:e});this.mouseDown(i.x,i.y),this.mouseClick(i.x,i.y)}}touchStartListener(t){t.preventDefault(),a1(this.uiData.touchTimer)&&(this.uiData.touchTimer=setTimeout(()=>{this.resetBriCon(t)},this.opts.longTouchTimeout));const e=new Date().getTime(),i=ju({currentTime:e,touchCount:t.touches.length,isTouchdown:this.uiData.touchdown});if(this.uiData.touchdown=i.touchdown,this.uiData.currentTouchTime=i.currentTouchTime,Zu({currentTime:e,lastTouchTime:this.uiData.lastTouchTime,doubleTouchTimeout:this.opts.doubleTouchTimeout}).isDoubleTap){const s=$u(e);this.uiData.doubleTouch=s.doubleTouch,this.uiData.lastTouchTime=s.lastTouchTime;const n=t.target.getBoundingClientRect(),a=Oi({touch:t.targetTouches[0],canvasRect:n});this.setDragStart(a.x,a.y),this.resetBriCon(t);return}else{const s=Ju(e);this.uiData.doubleTouch=s.doubleTouch,this.uiData.lastTouchTime=s.lastTouchTime,this.setDragStart(0,0),this.setDragEnd(0,0)}Us(this.uiData.touchdown,t.touches.length)?this.uiData.multiTouchGesture=!1:this.uiData.multiTouchGesture=!0,setTimeout(this.checkMultitouch.bind(this),1,t)}touchEndListener(t){t.preventDefault();const e=_u();if(this.uiData.touchdown=e.touchdown,this.uiData.lastTwoTouchDistance=e.lastTwoTouchDistance,this.uiData.multiTouchGesture=e.multiTouchGesture,this.uiData.touchTimer&&(clearTimeout(this.uiData.touchTimer),this.uiData.touchTimer=null),this.uiData.isDragging){this.uiData.isDragging=!1;for(const s of this.getZarrVolumes())s.zarrHelper?.endDrag();this.getCurrentDragMode()===1&&(this.calculateNewRange(),this.refreshLayers(this.volumes[0],0));const i=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),r=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);this.generateMouseUpCallback(i,r)}this.mouseUpListener()}windowingHandler(t,e,i=0){Math.sqrt((t-this.uiData.windowX)**2+(e-this.uiData.windowY)**2)>100&&(this.uiData.windowX=t,this.uiData.windowY=e);const s=V1({x:t,y:e,windowX:this.uiData.windowX,windowY:this.uiData.windowY,currentCalMin:this.volumes[i].cal_min,currentCalMax:this.volumes[i].cal_max,globalMin:this.volumes[i].global_min,globalMax:this.volumes[i].global_max,gainFactor:this.opts.windowingGainFactor??2});this.volumes[i].cal_min=s.calMin,this.volumes[i].cal_max=s.calMax,this.refreshLayers(this.volumes[i],0),this.uiData.windowX=s.windowX,this.uiData.windowY=s.windowY}mouseLeaveListener(){if(this.clickToSegmentIsGrowing&&(F.debug("Mouse left canvas, stopping clickToSegment preview."),this.clickToSegmentIsGrowing=!1,this.refreshDrawing(!0,!1)),this.opts.drawingEnabled&&!isNaN(this.drawPenLocation[0])&&(F.debug("Mouse left canvas during drawing, resetting pen state."),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawPenFillPts=[]),this.opts.drawingEnabled&&!isNaN(this.drawShapeStartLocation[0])&&(F.debug("Mouse left canvas during shape drawing, resetting shape state."),this.drawShapeStartLocation=[NaN,NaN,NaN],this.drawShapePreviewBitmap&&(this.drawBitmap=this.drawShapePreviewBitmap,this.drawShapePreviewBitmap=null,this.refreshDrawing(!0,!1))),this.uiData.isDragging||this.uiData.mousedown){F.debug("Mouse left canvas during drag, resetting drag state."),this.uiData.isDragging=!1;for(const e of this.getZarrVolumes())e.zarrHelper?.endDrag();const t=oa();this.uiData.mouseButtonLeftDown=t.mouseButtonLeftDown,this.uiData.mouseButtonCenterDown=t.mouseButtonCenterDown,this.uiData.mouseButtonRightDown=t.mouseButtonRightDown,this.uiData.mousedown=t.mousedown,this.drawScene()}this.mousePos=la()}mouseMoveListener(t){this.uiData.mousedown&&this.drawScene();const e=this.getNoPaddingNoBorderCanvasRelativeMousePosition(t,this.gl.canvas);if(e){if(!this.eventInBounds(t)){this.updateMousePos(e.x,e.y);return}if(this.uiData.mousedown){this.canvas.focus();const i=e.x*this.uiData.dpr,r=e.y*this.uiData.dpr;if(this.tileIndex(i,r)!==this.uiData.clickedTile)return;const n=this.getCurrentDragMode();if(n===8){if(this.mouseMove(e.x,e.y),!!this.mouseClick(e.x,e.y)&&this.uiData.prevX===this.uiData.currX&&this.uiData.prevY===this.uiData.currY)return;this.mouseClick(e.x,e.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY;return}if(n===9){this.windowingHandler(e.x,e.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY;return}this.setDragEnd(e.x,e.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY}else if(this.getCurrentDragMode()===7&&this.uiData.angleState==="drawing_second_line"){const i=this.getNoPaddingNoBorderCanvasRelativeMousePosition(t,this.gl.canvas);if(!i)return;this.setDragEnd(i.x,i.y),this.drawScene()}else if(!this.uiData.mousedown&&this.opts.clickToSegment){const i=this.getNoPaddingNoBorderCanvasRelativeMousePosition(t,this.gl.canvas);if(!i)return;const r=i.x*this.uiData.dpr,s=i.y*this.uiData.dpr;this.mousePos=[r,s];const n=this.tileIndex(r,s);n>=0&&this.opts.drawingEnabled&&this.screenSlices[n].axCorSag<=2&&(this.clickToSegmentXY=[r,s],this.clickToSegmentIsGrowing=!0,this.doClickToSegment({x:r,y:s,tileIndex:n}))}}}resetBriCon(t=null){if(this.uiData.isDragging)return;if(!this.eventInBounds(t)){this.opts.showBoundsBorder=!1;return}let e=!1;this.opts.sliceType===4&&(e=!0);let i=0,r=0;if(t!==null&&("targetTouches"in t?(i=t.targetTouches[0].clientX-t.target.getBoundingClientRect().left,r=t.targetTouches[0].clientY-t.target.getBoundingClientRect().top):(i=t.offsetX,r=t.offsetY),i*=this.uiData.dpr,r*=this.uiData.dpr,this.inRenderTile(i,r)>=0&&(e=!0)),e){this.uiData.mouseDepthPicker=!0,this.drawScene(),this.drawScene();return}this.getCurrentDragMode()!==4&&(this.volumes.length<1||this.uiData.doubleTouch||(this.volumes[0].cal_min=this.volumes[0].robust_min,this.volumes[0].cal_max=this.volumes[0].robust_max,this._emitEvent("intensityChange",this.volumes[0]),this.onIntensityChange(this.volumes[0]),this.refreshLayers(this.volumes[0],0),this.drawScene()))}setDragStart(t,e){const[i,r]=Rs(t,e,this.uiData.dpr);this.uiData.dragStart[0]=i,this.uiData.dragStart[1]=r}setDragEnd(t,e){const[i,r]=Rs(t,e,this.uiData.dpr);this.uiData.dragEnd[0]=i,this.uiData.dragEnd[1]=r}touchMoveListener(t){if(Us(this.uiData.touchdown,t.touches.length)){const e=this.canvas.getBoundingClientRect();if(!this.uiData.isDragging){this.uiData.pan2DxyzmmAtMouseDown=ze(this.scene.pan2Dxyzmm);for(const s of this.getZarrVolumes())s.zarrHelper?.beginDrag()}if(this.uiData.isDragging=!0,n1({doubleTouch:this.uiData.doubleTouch,isDragging:this.uiData.isDragging})){const s=Oi({touch:t.targetTouches[0],canvasRect:t.target.getBoundingClientRect()});this.setDragEnd(s.x,s.y),this.drawScene();return}const i=this.getTouchDragMode(!1),r=i1({touch:t.touches[0],canvasRect:e});i===8?(this.mouseClick(r.x,r.y),this.mouseMove(r.x,r.y)):i===9&&(this.windowingHandler(r.x,r.y),this.drawScene())}else this.handlePinchZoom(t)}handlePinchZoom(t){if(t1(t.targetTouches.length,t.changedTouches.length)){const e=this.canvas.getBoundingClientRect(),i=e1({touch1:t.touches[0],touch2:t.touches[1],lastTwoTouchDistance:this.uiData.lastTwoTouchDistance}),r=s1({touch:t.touches[0],canvasRect:e});this.mousePos=r,this.uiData.lastTwoTouchDistance>0&&this.sliceScroll2D(i.scrollDelta,r[0],r[1]),this.uiData.lastTwoTouchDistance=i.distance}}cycleActiveClipPlane(){const t=d1({currentIndex:this.uiData.activeClipPlaneIndex,clipPlanesLength:this.scene.clipPlanes.length});this.uiData.activeClipPlaneIndex=t.newIndex;const e=t.newIndex;return this.scene.clipPlanes[e]||(this.scene.clipPlanes[e]=t.defaultClipPlane),this.scene.clipPlaneDepthAziElevs[e]||(this.scene.clipPlaneDepthAziElevs[e]=t.defaultDepthAziElev),e}keyUpListener(t){if(!this.cursorInBounds()){this.opts.showBoundsBorder=!1,this.drawScene();return}const e=new Date().getTime(),i=h1({currentTime:e,lastCalledTime:this.lastCalled,debounceTime:this.opts.keyDebounceTime});if(zi(t.code,this.opts.cycleClipPlaneHotKey)&&i){const r=this.cycleActiveClipPlane();console.log("Active clip plane cycled to:",r),console.log("clip planes",this.scene.clipPlanes),this.lastCalled=e}if(zi(t.code,this.opts.clipPlaneHotKey)){if(i){const r=f1({currentClipPlaneIndex:this.currentClipPlaneIndex});this.currentClipPlaneIndex=r.newIndex,this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=r.depthAziElev,this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])}this.lastCalled=e}else if(zi(t.code,this.opts.viewModeHotKey)&&i){const r=u1({currentSliceType:this.opts.sliceType,totalSliceTypes:5});this.setSliceType(r),this.lastCalled=e}this.drawScene()}keyDownListener(t){if(!this.cursorInBounds()){this.opts.showBoundsBorder=!1,this.drawScene();return}const{action:e}=l1({code:t.code,ctrlKey:t.ctrlKey,shiftKey:t.shiftKey,sliceType:this.opts.sliceType});switch(e){case"render_azimuth_decrease":this.setRenderAzimuthElevation(this.scene.renderAzimuth-1,this.scene.renderElevation);break;case"render_azimuth_increase":this.setRenderAzimuthElevation(this.scene.renderAzimuth+1,this.scene.renderElevation);break;case"render_elevation_increase":this.setRenderAzimuthElevation(this.scene.renderAzimuth,this.scene.renderElevation+1);break;case"render_elevation_decrease":this.setRenderAzimuthElevation(this.scene.renderAzimuth,this.scene.renderElevation-1);break;case"crosshair_left":this.moveCrosshairInVox(-1,0,0);break;case"crosshair_right":this.moveCrosshairInVox(1,0,0);break;case"crosshair_up":this.moveCrosshairInVox(0,1,0);break;case"crosshair_down":this.moveCrosshairInVox(0,-1,0);break;case"crosshair_forward":this.moveCrosshairInVox(0,0,1);break;case"crosshair_backward":this.moveCrosshairInVox(0,0,-1);break;case"cycle_drag_mode":this.opts.dragMode=c1(this.opts.dragMode),F.info("drag mode changed to ",On[this.opts.dragMode]);break;case"frame_previous":this.setFrame4D(this.volumes[0].id,this.volumes[0].frame4D-1);break;case"frame_next":this.setFrame4D(this.volumes[0].id,this.volumes[0].frame4D+1);break;case"show_version":alert(`NIIVUE VERSION: ${Ys}`);break}this.drawScene()}wheelListener(t){const e=y1({thumbnailVisible:this.thumbnailVisible,mosaicStringLength:this.opts.sliceMosaicString.length,eventInBounds:this.eventInBounds(t),hasBounds:this.opts.bounds!==null});if(!e.shouldProcess){this.eventInBounds(t)||(this.opts.showBoundsBorder=!1,this.drawScene());return}if(this.opts.showBoundsBorder=e.showBoundsBorder,t.preventDefault(),t.stopPropagation(),p1({dragMode:this.getCurrentDragMode(),dragStart:this.uiData.dragStart,dragEnd:this.uiData.dragEnd})){const o=A1(t.deltaY),l=g1({dragStart:this.uiData.dragStart,dragEnd:this.uiData.dragEnd,delta:o});this.uiData.dragStart[0]=l.newDragStart[0],this.uiData.dragStart[1]=l.newDragStart[1],this.uiData.dragEnd[0]=l.newDragEnd[0],this.uiData.dragEnd[1]=l.newDragEnd[1],this.uiData.isDragging=!0,this.drawScene(),this.uiData.isDragging=!1;const c=this.tileIndex(this.uiData.dragStart[0],this.uiData.dragStart[1]);c>=0?this.generateMouseUpCallback(this.screenXY2TextureFrac(this.uiData.dragStart[0],this.uiData.dragStart[1],c),this.screenXY2TextureFrac(this.uiData.dragEnd[0],this.uiData.dragEnd[1],c)):F.warn("Could not generate drag release callback for ROI selection: Invalid tile index.");return}const i=m1({deltaY:t.deltaY,invertScrollDirection:this.opts.invertScrollDirection});if(this.opts.clickToSegment){this.opts.clickToSegmentPercent=w1({currentPercent:this.opts.clickToSegmentPercent,scrollAmount:i});const o=this.clickToSegmentXY[0],l=this.clickToSegmentXY[1],c=this.tileIndex(o,l);c>=0&&this.screenSlices[c].axCorSag<=2&&(F.debug(`Adjusting clickToSegment threshold: ${this.opts.clickToSegmentPercent.toFixed(3)}`),this.clickToSegmentIsGrowing=!0,this.doClickToSegment({x:o,y:l,tileIndex:c}));return}const r=this.canvas.getBoundingClientRect(),[s,n]=C1(t.clientX,t.clientY,r),a=this.inRenderTile(this.uiData.dpr*s,this.uiData.dpr*n)!==-1;if(b1({dragMode:this.getCurrentDragMode(),isInRenderTile:a})){const o=x1({currentZoom:this.scene.pan2Dxyzmm[3],scrollAmount:i});this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=o.newZoom),this.scene.pan2Dxyzmm[3]=o.newZoom;const l=this.frac2mm(this.scene.crosshairPos),c=v1({currentPan:[this.scene.pan2Dxyzmm[0],this.scene.pan2Dxyzmm[1],this.scene.pan2Dxyzmm[2]],zoomChange:o.zoomChange,crosshairMM:[l[0],l[1],l[2]]});this.scene.pan2Dxyzmm[0]=c[0],this.scene.pan2Dxyzmm[1]=c[1],this.scene.pan2Dxyzmm[2]=c[2],this.drawScene(),this.canvas.focus(),this.sync();return}this.sliceScroll2D(i,s,n)}registerInteractions(){if(!this.canvas)throw new Error("canvas undefined");Ke(this,ft,new AbortController);const{signal:t}=X(this,ft);this.canvas.addEventListener("mousedown",this.mouseDownListener.bind(this),{signal:t}),this.canvas.addEventListener("mouseup",this.mouseUpListener.bind(this),{signal:t}),this.canvas.addEventListener("mousemove",this.mouseMoveListener.bind(this),{signal:t}),this.canvas.addEventListener("mouseleave",this.mouseLeaveListener.bind(this),{signal:t}),this.canvas.addEventListener("touchstart",this.touchStartListener.bind(this),{signal:t}),this.canvas.addEventListener("touchend",this.touchEndListener.bind(this),{signal:t}),this.canvas.addEventListener("touchmove",this.touchMoveListener.bind(this),{signal:t}),this.canvas.addEventListener("wheel",this.wheelListener.bind(this),{signal:t}),this.canvas.addEventListener("contextmenu",this.mouseContextMenuListener.bind(this),{signal:t}),this.canvas.addEventListener("dblclick",this.resetBriCon.bind(this),{signal:t}),this.canvas.addEventListener("dragenter",this.dragEnterListener.bind(this),{signal:t}),this.canvas.addEventListener("dragover",this.dragOverListener.bind(this),{signal:t}),this.canvas.addEventListener("drop",e=>{this.dropListener(e).catch(console.error)},{signal:t}),this.canvas.setAttribute("tabindex","0"),this.canvas.addEventListener("keyup",this.keyUpListener.bind(this),{signal:t}),this.canvas.addEventListener("keydown",this.keyDownListener.bind(this),{signal:t})}dragEnterListener(t){ea(t)}dragOverListener(t){ta(t)}getFileExt(t,e=!0){return Lr(t,e)}async addVolumeFromUrl(t){const e=await Me.loadFromUrl(t);return this.document.addImageOptions(e,t),e.onColormapChange=this.onColormapChange,this.mediaUrlMap.set(e,t.url),this._emitEvent("volumeAddedFromUrl",{imageOptions:t,volume:e}),this.onVolumeAddedFromUrl&&this.onVolumeAddedFromUrl(t,e),this.addVolume(e),e}async addVolumesFromUrl(t){const e=t.map(async r=>{const s=this.getFileExt(r.name||r.url);if(s==="DCM")throw new Error("DICOM files must be loaded using useDicomLoader");if(this.loaders[s]){let o=r.url;const l=this.loaders[s].toExt;let c=r.name||r.url;if(c=c.split("/").pop(),typeof r.url=="string"){const d=r.url;try{const f=await fetch(d);if(!f.ok)throw new Error(`Failed to load file: ${f.statusText}`);o=await f.arrayBuffer()}catch(f){throw new Error(`Failed to load url ${d}: ${f}`)}}const h=await this.loaders[s].loader(o);r.url=h,r.name=`${c}.${l}`}const n={url:r.url,headers:r.headers,name:r.name,colormap:r.colormap?r.colormap:r.colorMap,colormapNegative:r.colormapNegative?r.colormapNegative:r.colorMapNegative,opacity:r.opacity,urlImgData:r.urlImgData,cal_min:r.cal_min,cal_max:r.cal_max,trustCalMinMax:this.opts.trustCalMinMax,isManifest:r.isManifest,frame4D:r.frame4D,limitFrames4D:r.limitFrames4D||this.opts.limitFrames4D,colorbarVisible:r.colorbarVisible,zarrLevel:r.zarrLevel,zarrMaxVolumeSize:r.zarrMaxVolumeSize,zarrChannel:r.zarrChannel,zarrConvertUnits:r.zarrConvertUnits,zarrCenterMM:r.zarrCenterMM},a=await Me.loadFromUrl(n);return this.document.addImageOptions(a,n),a.onColormapChange=this.onColormapChange,this.mediaUrlMap.set(a,n.url),this._emitEvent("volumeAddedFromUrl",{imageOptions:n,volume:a}),this.onVolumeAddedFromUrl&&this.onVolumeAddedFromUrl(n,a),a}),i=await Promise.all(e);for(let r=0;r<i.length;r++)this.addVolume(i[r]);return i}getMediaByUrl(t){return _n(t,this.mediaUrlMap)}removeVolumeByUrl(t){const e=this.getMediaByUrl(t);if(e)this.removeVolume(e);else throw new Error("No volume with URL present")}async traverseFileTree(t,e="",i){return kr(t,e,i)}readDirectory(t){return $n(t)}isMeshExt(t){return jn(t)}async loadFromArrayBuffer(t,e){const i=this.getFileExt(e);if(Zt.includes(i)){await this.addMeshFromUrl({url:e,buffer:t});return}const r=si(e);r.buffer=t,r.name=e,await this.addVolumeFromUrl(r)}async loadFromFile(t){const e=this.getFileExt(t.name);if(Zt.includes(e)){await mt.loadFromFile({file:t,gl:this.gl,name:t.name}).then(i=>{this.addMesh(i)});return}await Me.loadFromFile({file:t,name:t.name}).then(i=>{this.addVolume(i)})}useLoader(t,e,i){this.loaders=Jn({loaders:this.loaders,loader:t,fileExt:e,toExt:i})}useDicomLoader(t){this.dicomLoader=t}getDicomLoader(){return this.dicomLoader}async dropListener(t){if(this.eventInBounds(t))this.opts.bounds&&(this.opts.showBoundsBorder=!0);else{this.opts.showBoundsBorder=!1;return}if(t.stopPropagation(),t.preventDefault(),!this.opts.dragAndDropEnabled)return;const e=t.dataTransfer;if(!e)return;const i=W1(e);i?await this.handleUrlDrop(i):K1(e)&&await this.handleFilesDrop(e.items,t.shiftKey,t.altKey),this.drawScene()}async handleUrlDrop(t){const e=this.getFileExt(t);switch(F.debug("dropped ext:",e),Vs(e)){case"mesh":await this.addMeshFromUrl({url:t});break;case"document":await this.loadDocumentFromUrl(t);break;default:await this.addVolumeFromUrl(si(t))}}async handleFilesDrop(t,e,i){!e&&!i&&(this.volumes=[],this.overlays=[],this.meshes=[]),this.closeDrawing(),this.closePAQD();const r=Y1(t);for(const{entry:n,pairedEntry:a}of r)await this.handleFileEntry(n,a,i);const s=X1(t);for(const n of s)await this.handleDirectoryDrop(n)}async handleFileEntry(t,e,i){const r=this.getFileExt(t.name);if(this.loaders[r]){const a=await b0(t);await this.loadImages([{url:a,name:t.name}]);return}const s=await Ps(t);switch(Vs(r)){case"mesh":await this.handleMeshFileDrop(s);break;case"document":await this.handleDocumentFileDrop(s);break;default:await this.handleVolumeFileDrop(s,e,i)}}async handleMeshFileDrop(t){try{const e=await mt.loadFromFile({file:t,gl:this.gl,name:t.name});this.addMesh(e)}catch(e){console.error("Error loading mesh:",e)}}async handleDocumentFileDrop(t){try{const e=await St.loadFromFile(t);await this.loadDocument(e),F.debug("loaded document")}catch(e){console.error("Error loading document:",e)}}async handleVolumeFileDrop(t,e,i){try{let r;e&&(r=await Ps(e));const s=await Me.loadFromFile({file:t,urlImgData:r,limitFrames4D:this.opts.limitFrames4D});i?(F.debug("alt key detected: assuming this is a drawing overlay"),this.drawClearAllUndoBitmaps(),this.loadDrawing(s)):this.addVolume(s)}catch(r){console.error("Error loading volume:",r)}}async handleDirectoryDrop(t){try{const e=await this.traverseFileTree(t,"",[]),i=this.getDicomLoader().loader;if(!i)throw new Error("No loader for DICOM files");const s=(await i(e)).map(a=>Me.loadFromUrl({url:a.data,name:a.name,limitFrames4D:this.opts.limitFrames4D})),n=await Promise.all(s);this._emitEvent("dicomLoaderFinished",{files:n}),await this.onDicomLoaderFinishedWithImages(n)}catch(e){console.error("Error loading DICOM files:",e)}}setMultiplanarPadPixels(t){this.opts.multiplanarPadPixels=t,this.drawScene()}setMultiplanarLayout(t){typeof t=="string"&&(t=parseInt(t)),this.opts.multiplanarLayout=t,this.drawScene()}setCornerOrientationText(t){this.opts.isCornerOrientationText=t,this.updateGLVolume()}setIsOrientationTextVisible(t){this.opts.isOrientationTextVisible=t,this.drawScene()}setShowAllOrientationMarkers(t){this.opts.showAllOrientationMarkers=t,this.drawScene()}setHeroImage(t){this.opts.heroImageFraction=t,this.drawScene()}setCustomLayout(t){const e=i2({layout:t});if(!e.valid&&e.error)throw new Error(e.error);this.customLayout=t,this.drawScene()}clearCustomLayout(){this.customLayout=null,this.drawScene()}getCustomLayout(){return this.customLayout}setRadiologicalConvention(t){this.opts.isRadiologicalConvention=t,this.updateGLVolume()}setDefaults(t={},e=!1){this.document.opts={...ke},this.scene.sceneData={...mi};for(const i in t)typeof t[i]=="function"?this[i]=t[i]:this.opts[i]=ke[i]===void 0?ke[i]:t[i];if(this.scene.pan2Dxyzmm=[0,0,0,1],e&&this.volumes&&this.volumes.length>0)for(let i=0;i<this.volumes.length;i++)this.volumes[i].cal_min=this.volumes[i].robust_min,this.volumes[i].cal_max=this.volumes[i].robust_max;this.updateGLVolume()}setMeshThicknessOn2D(t){this.opts.meshThicknessOn2D=t,this.updateGLVolume()}setSliceMosaicString(t){this.sliceMosaicString=t,this.updateGLVolume()}setSliceMM(t){this.opts.isSliceMM=t,this.updateGLVolume()}setAdditiveBlend(t){this.opts.isAdditiveBlend=t,this.updateGLVolume()}getRadiologicalConvention(){return this.opts.isRadiologicalConvention}setHighResolutionCapable(t){typeof t=="boolean"&&(t=t?0:-1),this.opts.forceDevicePixelRatio=t,this.resizeListener(),this.drawScene()}watchOptsChanges(t){this.onOptsChange=t}unwatchOptsChanges(){this.onOptsChange=()=>{}}addVolume(t){const e=Qd(this.volumes,t);if(this.volumes=e.volumes,this.setVolume(t,e.index),this._emitEvent("imageLoaded",t),this.onImageLoaded(t),t.zarrHelper){if(!t._hasExplicitZarrCenter&&this.back&&this.back!==t&&this.back.hdr?.dims){const i=this.back,r=i.hdr.dims,s=i.hdr.affine,n=(r[1]-1)/2,a=(r[2]-1)/2,o=(r[3]-1)/2,l=[s[0][0]*n+s[0][1]*a+s[0][2]*o+s[0][3],s[1][0]*n+s[1][1]*a+s[1][2]*o+s[1][3],s[2][0]*n+s[2][1]*a+s[2][2]*o+s[2][3]];t.zarrHelper.setWorldCenter(l)}t.zarrHelper.onChunksUpdated=()=>{this.updateGLVolume(),this._skipDragInDraw=!0,this.drawScene(),this._skipDragInDraw=!1},t.zarrHelper.loadInitialChunks().catch(i=>F.error("Failed to load initial zarr chunks",i))}F.debug("loaded volume",t.name),F.debug(t)}addMesh(t){const e=Vf(this.meshes,t);this.meshes=e.meshes,this.setMesh(t,e.index),this._emitEvent("meshLoaded",t),this.onMeshLoaded(t)}getVolumeIndexByID(t){return At(this.volumes,t)}drawAddUndoBitmap(t=!0){const e=k2({drawBitmap:this.drawBitmap,drawUndoBitmaps:this.drawUndoBitmaps,currentDrawUndoBitmap:this.currentDrawUndoBitmap,maxDrawUndoBitmaps:this.opts.maxDrawUndoBitmaps,drawFillOverwrites:t});this.drawBitmap=e.drawBitmap,this.drawUndoBitmaps=e.drawUndoBitmaps,this.currentDrawUndoBitmap=e.currentDrawUndoBitmap,e.needsRefresh&&this.refreshDrawing(!1)}drawClearAllUndoBitmaps(){const t=L2(this.drawUndoBitmaps,this.opts.maxDrawUndoBitmaps);this.drawUndoBitmaps=t.drawUndoBitmaps,this.currentDrawUndoBitmap=t.currentDrawUndoBitmap}drawUndo(){const{drawBitmap:t,currentDrawUndoBitmap:e}=F2({drawUndoBitmaps:this.drawUndoBitmaps,currentDrawUndoBitmap:this.currentDrawUndoBitmap,drawBitmap:this.drawBitmap});this.drawBitmap=t,this.currentDrawUndoBitmap=e,this.refreshDrawing(!0),this._emitEvent("drawingChanged",{action:"undo"}),this.onDrawingChanged("undo")}loadDrawing(t){if(this.drawBitmap&&F.debug("Overwriting open drawing!"),!this.back)throw new Error("back undefined");this.drawClearAllUndoBitmaps();const e=t.hdr.dims;if(!G2({drawingDims:e,backgroundDims:this.back.hdr.dims}))return F.debug("drawing dimensions do not match background image"),!1;t.img.constructor!==Uint8Array&&F.debug("Drawings should be UINT8");const i=t.permRAS,r=Wi(e);this.drawBitmap=Ki(r),this.opts.is2DSliceShader?this.drawTexture=this.r8Tex2D(this.drawTexture,$.TEXTURE7_DRAW,this.back.dims,!0):this.drawTexture=this.r8Tex(this.drawTexture,$.TEXTURE7_DRAW,this.back.dims,!0);const s=O2({permRAS:i,dims:e});return this.drawBitmap=z2({inputData:t.img,dims:e,xlut:s.xlut,ylut:s.ylut,zlut:s.zlut}),this.drawAddUndoBitmap(),this.refreshDrawing(!1),this._emitEvent("drawingChanged",{action:"load"}),this.onDrawingChanged("load"),this.drawScene(),!0}binarize(t){const e=fm({img:t.img,dims:t.hdr.dims});t.img=e.img,t.hdr.datatypeCode=e.datatypeCode,t.hdr.cal_min=e.cal_min,t.hdr.cal_max=e.cal_max}async loadDrawingFromUrl(t,e=!1){this.drawBitmap&&F.debug("Overwriting open drawing!"),this.drawClearAllUndoBitmaps();let i=!1;try{const r=await Me.loadFromUrl(si(t));e&&await this.binarize(r),i=this.loadDrawing(r)}catch{F.error("loadDrawingFromUrl() failed to load "+t),this.drawClearAllUndoBitmaps()}return i}findOtsu(t=2){return this.volumes.length<1?[]:um({img:this.volumes[0].img,cal_min:this.volumes[0].cal_min,cal_max:this.volumes[0].cal_max,scl_inter:this.volumes[0].hdr.scl_inter,scl_slope:this.volumes[0].hdr.scl_slope,mlevel:t})}drawOtsu(t=2){if(this.volumes.length===0)return;const e=this.findOtsu(t);if(e.length<3)return;this.drawBitmap||this.createEmptyDrawing();const i=mm({img:this.volumes[0].img2RAS(),drawBitmap:this.drawBitmap,thresholds:e});this.drawBitmap.set(i),this.drawAddUndoBitmap(),this.refreshDrawing(!0)}removeHaze(t=5,e=0){const i=this.volumes[e].img,r=this.volumes[e].hdr,s=pm({level:t}),n=this.findOtsu(s);if(n.length<3)return;const a=gm({level:t,thresholds:n});Am({img:i,scl_inter:r.scl_inter,scl_slope:r.scl_slope,global_min:this.volumes[e].global_min,threshold:a}),this.refreshLayers(this.volumes[e],0),this.drawScene()}async saveImage(t=Ks){const e={...Ks,...t},{filename:i,isSaveDrawing:r,volumeByIndex:s}=e;return F.debug("saveImage",i,r,s),this.back?.dims===void 0?(F.debug("No voxelwise image open"),!1):r?this.drawBitmap?await this.volumes[0].saveToDisk(i,this.drawBitmap):(F.debug("No drawing open"),!1):(F.debug("saving image"),this.volumes[s].saveToDisk(i))}getMeshIndexByID(t){return Ze(this.meshes,t)}setMeshProperty(t,e,i){const r=Nf({meshes:this.meshes,id:t,key:e,val:i,gl:this.gl});r<0||(this.updateGLVolume(),this._emitEvent("meshPropertyChanged",{meshIndex:r,key:e,value:i}),this.onMeshPropertyChanged(r,e,i))}indexNearestXYZmm(t,e,i,r){return Lf({meshes:this.meshes,meshId:t,Xmm:e,Ymm:i,Zmm:r})}decimateHierarchicalMesh(t,e=3){const i=kf({meshes:this.meshes,meshId:t,gl:this.gl,order:e});return i&&this.updateGLVolume(),i}reverseFaces(t){Of({meshes:this.meshes,meshId:t,gl:this.gl})&&this.updateGLVolume()}async setMeshLayerProperty(t,e,i,r){await zf({meshes:this.meshes,meshId:t,layer:e,key:i,val:r,gl:this.gl})&&this.updateGLVolume()}setPan2Dxyzmm(t){this.scene.pan2Dxyzmm=t,this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=t[3]),this.drawScene()}setRenderAzimuthElevation(t,e){this.scene.renderAzimuth=t,this.scene.renderElevation=e,this._emitEvent("azimuthElevationChange",{azimuth:t,elevation:e}),this.onAzimuthElevationChange(t,e),this.drawScene()}getOverlayIndexByID(t){return Zd(this.volumes,t)}setVolume(t,e=0){const i=xt(this.volumes,t,e);this.volumes=i.volumes,this.back=i.back,this.overlays=i.overlays,this.updateGLVolume()}setMesh(t,e=0){this.meshes.forEach(r=>{F.debug("MESH: ",r.name)});const i=Pf(this.meshes,t,e);this.meshes=i.meshes,this.updateGLVolume(),this.meshes.forEach(r=>{F.debug(r.name)})}removeVolume(t){const e=this.volumes.indexOf(t),i=qn(this.volumes,t);if(this.volumes=i.volumes,this.back=this.volumes.length>0?this.volumes[0]:null,this.overlays=this.volumes.slice(1),this._emitEvent("volumeRemoved",{volume:t,index:e}),this.onVolumeRemoved(t,e),this.mediaUrlMap.has(t)){const r=this.mediaUrlMap.get(t);this._emitEvent("volumeWithUrlRemoved",{url:r}),this.onVolumeWithUrlRemoved(r),this.mediaUrlMap.delete(t)}this.updateGLVolume(),this.drawScene()}removeVolumeByIndex(t){const e=jd(this.volumes,t);e.removed&&this.removeVolume(e.removed)}removeMesh(t){if(this._emitEvent("meshRemoved",{mesh:t}),this.onMeshRemoved(t),t.unloadMesh(this.gl),this.setMesh(t,-1),this.mediaUrlMap.has(t)){const e=this.mediaUrlMap.get(t);this._emitEvent("meshWithUrlRemoved",{url:e}),this.onMeshWithUrlRemoved(e),this.mediaUrlMap.delete(t)}}removeMeshByUrl(t){const e=this.getMediaByUrl(t);e&&(this.removeMesh(e),this.mediaUrlMap.delete(e),this._emitEvent("meshWithUrlRemoved",{url:t}),this.onMeshWithUrlRemoved(t))}moveVolumeToBottom(t){const e=_d(this.volumes,t);this.volumes=e.volumes,this.back=e.back,this.overlays=e.overlays,this.updateGLVolume(),this._emitEvent("volumeOrderChanged",{volumes:this.volumes}),this.onVolumeOrderChanged(this.volumes)}moveVolumeUp(t){const e=Jd(this.volumes,t);this.volumes=e.volumes,this.back=e.back,this.overlays=e.overlays,this.updateGLVolume(),this._emitEvent("volumeOrderChanged",{volumes:this.volumes}),this.onVolumeOrderChanged(this.volumes)}moveVolumeDown(t){const e=$d(this.volumes,t);this.volumes=e.volumes,this.back=e.back,this.overlays=e.overlays,this.updateGLVolume(),this._emitEvent("volumeOrderChanged",{volumes:this.volumes}),this.onVolumeOrderChanged(this.volumes)}moveVolumeToTop(t){const e=ef(this.volumes,t);this.volumes=e.volumes,this.back=e.back,this.overlays=e.overlays,this.updateGLVolume(),this._emitEvent("volumeOrderChanged",{volumes:this.volumes}),this.onVolumeOrderChanged(this.volumes)}mouseDown(t,e){const i=hr({x:t,y:e,dpr:this.uiData.dpr});this.mousePos=i.mousePos}updateMousePos(t,e){const i=hr({x:t,y:e,dpr:this.uiData.dpr});return this.mousePos=i.mousePos,i.mousePos}mouseMove(t,e){const i=aa({x:t,y:e,dpr:this.uiData.dpr,currentMousePos:this.mousePos});if(this.mousePos=i.mousePos,this.inRenderTile(i.scaledX,i.scaledY)<0||!A2({dx:i.dx,dy:i.dy}))return;const r=g2({currentAzimuth:this.scene.renderAzimuth,currentElevation:this.scene.renderElevation,deltaX:i.dx,deltaY:i.dy});this.scene.renderAzimuth===r.azimuth&&this.scene.renderElevation===r.elevation||this.setRenderAzimuthElevation(r.azimuth,r.elevation)}sph2cartDeg(t,e){return bi(t,e)}setClipPlanes(t){const e=D2({depthAziElevs:t});this.scene.clipPlanes=e.clipPlanes,this.scene.clipPlaneDepthAziElevs=e.clipPlaneDepthAziElevs,this.drawScene()}setClipPlane(t){if(!E2(t))return;const e=this.uiData.activeClipPlaneIndex??0,i=S2({clipPlanes:this.scene.clipPlanes,clipPlaneDepthAziElevs:this.scene.clipPlaneDepthAziElevs,index:e,depthAzimuthElevation:t});this.scene.clipPlanes=i.clipPlanes,this.scene.clipPlaneDepthAziElevs=i.clipPlaneDepthAziElevs,this._emitEvent("clipPlaneChange",{clipPlane:i.clipPlane}),this.onClipPlaneChange(i.clipPlane),this.drawScene()}setCrosshairColor(t){this.opts.crosshairColor=t,this.drawScene()}setCrosshairWidth(t){this.opts.crosshairWidth=t,this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN),this.drawScene()}setDrawColormap(t){this.drawLut=re.makeDrawLut(t),this.updateGLVolume()}setDrawingEnabled(t){if(this.opts.drawingEnabled=t,this._emitEvent("drawingEnabled",{enabled:t}),this.onDrawingEnabled(t),this.opts.drawingEnabled)this.drawBitmap||this.createEmptyDrawing();else{const e=X2({clickToSegmentIsGrowing:this.clickToSegmentIsGrowing,drawPenLocation:this.drawPenLocation,drawPenAxCorSag:this.drawPenAxCorSag,drawPenFillPts:this.drawPenFillPts,drawShapeStartLocation:this.drawShapeStartLocation,drawShapePreviewBitmap:this.drawShapePreviewBitmap,drawBitmap:this.drawBitmap});this.clickToSegmentIsGrowing=e.clickToSegmentIsGrowing,this.drawPenLocation=e.drawPenLocation,this.drawPenAxCorSag=e.drawPenAxCorSag,this.drawPenFillPts=e.drawPenFillPts,this.drawShapeStartLocation=e.drawShapeStartLocation,this.drawShapePreviewBitmap=e.drawShapePreviewBitmap,this.drawBitmap=e.drawBitmap,e.needsRefresh&&this.refreshDrawing(!0,!1);const i=this._deriveDrawingTool(this.opts.penValue);this._emitEvent("drawingToolChanged",{tool:i,penValue:this.opts.penValue,isFilledPen:this.opts.isFilledPen}),this.onDrawingToolChanged(i,this.opts.penValue,this.opts.isFilledPen)}this.drawScene()}setPenValue(t,e=!1){this.opts.penValue=t,this.opts.isFilledPen=e,this._emitEvent("penValueChanged",{penValue:t,isFilledPen:e}),this.onPenValueChanged(t,e);const i=this._deriveDrawingTool(t);this._emitEvent("drawingToolChanged",{tool:i,penValue:t,isFilledPen:e}),this.onDrawingToolChanged(i,t,e),this.drawScene()}_deriveDrawingTool(t){return this.opts.drawingEnabled?this.opts.clickToSegment?"clickToSegment":Object.is(t,-0)?"eraseCluster":isNaN(t)?"growCluster":t===Number.POSITIVE_INFINITY?"growClusterBright":t===Number.NEGATIVE_INFINITY?"growClusterDark":t===0?"erase":"draw":"off"}setDrawOpacity(t){this.drawOpacity=t,this.drawScene()}setSelectionBoxColor(t){this.opts.selectionBoxColor=t}setBounds(t){if(!Array.isArray(t)||t.length!==4)throw new Error("setBounds: expected [x1,y1,x2,y2] array");this.opts.bounds=[[t[0],t[1]],[t[2],t[3]]],this.gl&&this.drawScene()}sliceScroll2D(t,e,i,r=!0){if(!e2({scrollRequiresFocus:this.opts.scrollRequiresFocus,canvasHasFocus:this.canvas===document.activeElement})){F.warn("Canvas element does not have focus. Scroll events will not be processed.");return}if(this.inGraphTile(e,i)){let n=this.volumes[0].frame4D;t>0&&n++,t<0&&n--,this.setFrame4D(this.volumes[0].id,n);return}const s=this.inRenderTile(this.uiData.dpr*e,this.uiData.dpr*i)!==-1;if(t2({posChange:t,dragMode:this.opts.dragMode,isInRenderTile:s})){const n=this.frac2mm(this.scene.crosshairPos),a=J1({posChange:t,currentZoom:this.scene.pan2Dxyzmm[3],yoke3Dto2DZoom:this.opts.yoke3Dto2DZoom,crosshairMM:n});a.newVolScaleMultiplier!==void 0&&(this.scene.volScaleMultiplier=a.newVolScaleMultiplier),this.scene.pan2Dxyzmm[3]=a.newZoom,this.scene.pan2Dxyzmm[0]+=a.panOffsetX,this.scene.pan2Dxyzmm[1]+=a.panOffsetY,this.scene.pan2Dxyzmm[2]+=a.panOffsetZ,this.drawScene(),this.canvas.focus(),this.sync();return}this.mouseClick(e,i,t,r)}setSliceType(t){return this.opts.sliceType=t,this._emitEvent("sliceTypeChange",{sliceType:t}),this.onSliceTypeChange(t),this.drawScene(),this}setOpacity(t,e){tf(this.volumes,t,e),this.updateGLVolume()}getVolumeAffine(t){if(t<0||t>=this.volumes.length)throw new Error(`Volume index ${t} out of range`);return this.volumes[t].getAffine()}setVolumeAffine(t,e){if(t<0||t>=this.volumes.length)throw new Error(`Volume index ${t} out of range`);this.volumes[t].setAffine(e),this.updateGLVolume()}applyVolumeTransform(t,e){if(t<0||t>=this.volumes.length)throw new Error(`Volume index ${t} out of range`);this.volumes[t].applyTransform(e),this.updateGLVolume()}resetVolumeAffine(t){if(t<0||t>=this.volumes.length)throw new Error(`Volume index ${t} out of range`);this.volumes[t].resetAffine(),this.updateGLVolume()}setScale(t){this.scene.volScaleMultiplier=t,this.drawScene()}setClipPlaneColor(t){this.opts.clipPlaneColor=t,this.renderShader.use(this.gl),this.gl.uniform4fv(this.renderShader.uniforms.clipPlaneColor,this.opts.clipPlaneColor),this.drawScene()}setClipPlaneThick(t){F.warn("setClipPlaneThick() has been removed. use setClipPlanes() instead.")}setClipVolume(t,e){F.warn("setClipVolume() has been removed. use setClipPlanes() instead.")}async setVolumeRenderIllumination(t=0){this.renderGradientValues=Number.isNaN(t),this.renderShader=this.renderVolumeShader,this.renderGradientValues?this.renderShader=this.renderGradientValuesShader:(this.opts.gradientAmount=t,t>0||this.opts.gradientOpacity>0?this.renderShader=this.renderGradientShader:t<0&&(this.renderShader=this.renderSliceShader)),this.initRenderShader(this.renderShader,t),this.renderShader.use(this.gl),this.setClipPlaneColor(this.opts.clipPlaneColor),Number.isNaN(t)?this.gradientTextureAmount=1:this.gradientTextureAmount=t,!(this.volumes.length<1)&&(await this.refreshLayers(this.volumes[0],0),this.drawScene())}async setGradientOpacity(t=0,e=0){this.opts.gradientOpacity=t,this.opts.renderSilhouette=e,this.renderGradientValues?this.renderShader=this.renderGradientValuesShader:this.gradientTextureAmount>0||t>0?this.renderShader=this.renderGradientShader:this.gradientTextureAmount<0&&(this.renderShader=this.renderSliceShader),this.initRenderShader(this.renderShader,this.gradientTextureAmount),this.renderShader.use(this.gl),this.gradientTextureAmount>0&&this.refreshLayers(this.volumes[0],0),this.drawScene()}overlayRGBA(t){return af(t)}vox2mm(t,e){return I0(t,e)}cloneVolume(t){return rf(this.volumes,t)}async loadDocumentFromUrl(t){const e=await St.loadFromUrl(t);await this.loadDocument(e)}async loadDocument(t){try{if(!t)throw new Error("loadDocument called with falsy document");if(!t.scene||typeof t.scene!="object"){const r=new St;t.scene=r.scene}t.scene.sceneData={...mi,...t.scene.sceneData||{}},t.scene.sceneData.pan2Dxyzmm||(t.scene.sceneData.pan2Dxyzmm=ae(0,0,0,1)),t.scene.sceneData.crosshairPos||(t.scene.sceneData.crosshairPos=k(.5,.5,.5)),t.data={...t.data||{},imageOptionsArray:t.data?.imageOptionsArray??[],encodedImageBlobs:t.data?.encodedImageBlobs??[],labels:t.data?.labels??[],meshOptionsArray:t.data?.meshOptionsArray??[],connectomes:t.data?.connectomes??[],encodedDrawingBlob:t.data?.encodedDrawingBlob??"",previewImageDataURL:t.data?.previewImageDataURL??"",customData:t.data?.customData??"",title:t.data?.title??t.title??"untitled"}}catch(r){console.warn("loadDocument: defensive initialization failed",r)}this.volumes=[],this.meshes=[],this.document=t,this.document.labels=this.document.labels?this.document.labels:[];const e={...ke,...t.opts||{}};this.scene.pan2Dxyzmm=t.scene.sceneData?.pan2Dxyzmm??[0,0,0,1],this.document.opts=e,this.scene.clipPlaneDepthAziElevs&&this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex??0]),F.debug("load document",t),this.mediaUrlMap.clear(),this.createEmptyDrawing();try{const r=await xs.rehydrateImages(t.data);for(const s of r||[])try{this.addVolume(s)}catch(n){console.warn("Failed to add rehydrated image:",n,s)}}catch(r){console.warn("NVSerializer.rehydrateImages failed:",r)}this.volumes&&this.volumes.length>0?this.back=this.volumes[0]:this.volumes=[];try{const r=await xs.rehydrateMeshes(t.data,this.gl,!0);for(const s of r||[])try{typeof s.updateMesh=="function"&&s.updateMesh(this.gl),this.addMesh(s)}catch(n){console.error("Failed to add rehydrated mesh:",n,s)}}catch(r){console.warn("NVSerializer.rehydrateMeshes failed:",r)}if(t.data.connectomes)for(const r of t.data.connectomes)try{const s=JSON.parse(r),n=this.loadConnectomeAsMesh(s);n.updateMesh(this.gl),this.addMesh(n)}catch(s){console.warn("Failed to rehydrate connectome:",s)}this.createEmptyDrawing();const i=t.encodedDrawingBlob;if(i)try{const r=await H.b64toUint8(i);if(r){const s=this.back?.dims;if(!s)console.warn("No back image available; cannot validate drawBitmap size."),this.drawBitmap=r;else{let n=s[1]*s[2]*s[3];if(r.length-352===n&&(n+=352),r.length!==n)throw new Error(`drawBitmap size does not match the texture dimensions (${s[1]}×${s[2]}×${s[3]}) ${n} != ${s[1]*s[2]*s[3]}.`);this.drawBitmap=r,this.refreshDrawing()}}}catch(r){console.warn("Failed to decode drawBitmap:",r)}return await this.setGradientOpacity(this.opts.gradientOpacity),await this.setVolumeRenderIllumination(this.opts.gradientAmount),this.updateGLVolume(),this.drawScene(),this._emitEvent("documentLoaded",t),this.onDocumentLoaded(t),this}async generateLoadDocumentJavaScript(t,e){const i=this.json(),r=await H.compressToBase64String(JSON.stringify(i));return`
+        ${e}
+
+        async function saveNiivueAsHtml(pageName) {
+          //get new docstring
+          const docString = nv1.json();
+          const html =
+          document.getElementsByTagName("html")[0]
+              .innerHTML.replace(base64, await NVUtilities.compressToBase64String(JSON.stringify(docString)));
+          NVUtilities.download(html, pageName, "application/html");
+        }
+
+        var nv1 = new Niivue();
+        await nv1.attachTo("${t}");
+        var base64 = "${r}";
+        NVUtilities.decompressBase64String(base64).then((jsonText) => {
+          var json = JSON.parse(jsonText); // string -> JSON
+          var doc = NVDocument.loadFromJSON(json);
+          nv1.loadDocument(doc);
+          nv1.updateGLVolume();
+        });
+
+      `}async generateHTML(t="gl1",e){return`<!DOCTYPE html>
+        <html lang="en">
+          <head>
+            <meta charset="utf-8" />
+            <meta http-equiv="X-UA-Compatible" content="IE=edge" />
+            <meta name="viewport" content="width=device-width,initial-scale=1.0" />
+            <title>Save as HTML</title>
+            <style>
+            html {
+              height: auto;
+              min-height: 100%;
+              margin: 0;
+            }
+            body {
+              display: flex;
+              flex-direction: column;
+              margin: 0;
+              min-height: 100%;
+              width: 100%;
+              position: absolute;
+              font-family: system-ui, Arial, Helvetica, sans-serif;
+              background: #ffffff;
+              color: black;
+              user-select: none; /* Standard syntax */
+            }
+            header {
+              margin: 10px;
+            }
+            main {
+              flex: 1;
+              background: #000000;
+              position: relative;
+            }
+            footer {
+              margin: 10px;
+            }
+            canvas {
+              position: absolute;
+              cursor: crosshair;
+            }
+            canvas:focus {
+              outline: 0px;
+            }
+            div {
+              display: table-row;
+              background-color: blue;
+            }
+            </style>
+          </head>
+          <body>
+            <noscript>niivue requires JavaScript.</noscript>
+            <header>
+            Save the current scene as HTML
+            <button id="save">Save as HTML</button>
+            </header>
+            <main>
+              <canvas id="gl1"></canvas>
+            </main>
+            <script type="module" async>
+              ${await this.generateLoadDocumentJavaScript(t,e)}
+              function saveAsHtml() {
+                saveNiivueAsHtml("page.html");
+              }
+              // assign our event handler
+              var button = document.getElementById("save");
+              button.onclick = saveAsHtml;
+            <\/script>
+          </body>
+        </html>`}async saveHTML(t="untitled.html",e="gl1",i){const r=await this.generateHTML(e,i);return H.download(r,t,"application/html")}json(){return this.document.opts=this.opts,this.document.scene=this.scene,this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.json()}async saveDocument(t="untitled.nvd",e=!0,i={}){const{embedImages:r=!0,embedPreview:s=!0}=i;this.document.title=t,this.document.volumes=this.volumes,this.document.meshes=this.meshes,s?(this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL()):this.document.previewImageDataURL="",await this.document.download(t,e,{embedImages:r})}async loadImages(t){const e=[],i=[];for(const r of t)if("url"in r){const s=this.getFileExt(r.name?r.name:r.url);if(this.loaders[s]){const n=this.loaders[s].toExt.toUpperCase();Zt.includes(n)?i.push(r):e.push(r);continue}Zt.includes(s.toUpperCase())?i.push(r):e.push(r)}return e.length>0&&await this.loadVolumes(e),i.length>0&&await this.loadMeshes(i),this}async loadDicoms(t){if(!this.getDicomLoader())throw new Error("No dicom loader set. Please set a dicom loader before loading dicoms");this.drawScene(),this.volumes=[];const e=t.map(async r=>{let s=null;if(r.isManifest)s=await Me.fetchDicomData(r.url);else{const h=await fetch(r.url);if(!h.ok)throw new Error(`Failed to load file: ${h.statusText}`);const d=await h.arrayBuffer();s=[{name:r.url.split("/").pop(),data:d}]}const n=this.getDicomLoader().loader,a=await n(s),o=a[0].name,l=a[0].data;return await Me.loadFromUrl({url:l,name:o})}),i=await Promise.all(e);return i.length===1?this.addVolume(i[0]):(this._emitEvent("dicomLoaderFinished",{files:i}),this.onDicomLoaderFinishedWithImages(i)),this}async loadVolumes(t){return this.drawScene(),this.thumbnailVisible?(this.deferredVolumes=t,this):(this.volumes=[],this.closePAQD(),await this.addVolumesFromUrl(t),this)}async addMeshFromUrl(t){const e=this.getFileExt(t.url);if(e==="JCON"||e==="JSON"){let r;if(t.buffer){const n=ArrayBuffer.isView(t.buffer)?t.buffer:new Uint8Array(t.buffer),a=new TextDecoder("utf-8").decode(n);r=JSON.parse(a)}else r=await(await fetch(t.url)).json();const s=this.loadConnectomeAsMesh(r);return this.mediaUrlMap.set(s,t.url),this._emitEvent("meshAddedFromUrl",{meshOptions:t,mesh:s}),this.onMeshAddedFromUrl(t,s),this.addMesh(s),s}const i=await mt.loadFromUrl({...t,gl:this.gl});return this.mediaUrlMap.set(i,t.url),this._emitEvent("meshAddedFromUrl",{meshOptions:t,mesh:i}),this.onMeshAddedFromUrl(t,i),this.addMesh(i),i}async addMeshesFromUrl(t){const e=t.map(async r=>{const s=this.getFileExt(r.name||r.url);if(this.loaders[s]){let a=r.url;const o=this.loaders[s].toExt;let l=r.name||r.url;if(l=l.split("/").pop(),typeof r.url=="string"){const p=r.url;try{const g=await fetch(p);if(!g.ok)throw new Error(`Failed to load file: ${g.statusText}`);a=await g.arrayBuffer()}catch(g){throw new Error(`Failed to load url ${p}: ${g}`)}}const{positions:c,indices:h,colors:d=null,scalars:f=null,colormapLabel:u=null}=await this.loaders[s].loader(a);r.name=`${l}.${o}`;const m=await $e.createMZ3Async(c,h,!1,d,f,u);r.buffer=m}if(s==="JCON"||s==="JSON"){const o=await(await fetch(r.url,{})).json(),l=this.loadConnectomeAsMesh(o);return this.mediaUrlMap.set(l,r.url),this._emitEvent("meshAddedFromUrl",{meshOptions:r,mesh:l}),this.onMeshAddedFromUrl(r,l),l}const n=await mt.loadFromUrl({...r,gl:this.gl});return this.mediaUrlMap.set(n,r.url),this._emitEvent("meshAddedFromUrl",{meshOptions:r,mesh:n}),this.onMeshAddedFromUrl(r,n),n}),i=await Promise.all(e);for(let r=0;r<i.length;r++)this.addMesh(i[r]);return i}async loadMeshes(t){return this.drawScene(),this.thumbnailVisible?(this.deferredMeshes=t,this):(this.initialized,this.meshes=[],await this.addMeshesFromUrl(t),this.updateGLVolume(),this.drawScene(),this)}async loadConnectomeFromUrl(t,e={}){const r=await(await fetch(t,{headers:e})).json();return this.loadConnectome(r)}async loadFreeSurferConnectomeFromUrl(t,e={}){const r=await(await fetch(t,{headers:e})).json();return this.loadFreeSurferConnectome(r)}async loadFreeSurferConnectome(t){const e=ci.convertFreeSurferConnectome(t);return this.loadConnectome(e)}handleNodeAdded(t){const e=Xf(t.detail.node);this.addLabel(e.text,e.style,e.position),this.drawScene()}loadConnectomeAsMesh(t){return Yf({gl:this.gl,json:t})}loadConnectome(t){this.drawScene(),this.meshes=[];const e=this.loadConnectomeAsMesh(t);return this.addMesh(e),this.drawScene(),this}createEmptyDrawing(){if(this.back===null||!this.back.dims||Math.min(Math.min(this.back.dims[1],this.back.dims[2]),this.back.dims[3])<1)return;const e=Wi(this.back.dims);this.drawBitmap=Ki(e),this.clickToSegmentGrowingBitmap=Ki(e),this.drawClearAllUndoBitmaps(),this.drawAddUndoBitmap(),this.opts.is2DSliceShader?this.drawTexture=this.r8Tex2D(this.drawTexture,$.TEXTURE7_DRAW,this.back.dims):this.drawTexture=this.r8Tex(this.drawTexture,$.TEXTURE7_DRAW,this.back.dims,!0),this.refreshDrawing(!1)}drawGrowCut(){if(!this.back||!this.back.dims)throw new Error("back not defined");const t=this.back.hdr,e=this.gl,i=t.dims[1]*t.dims[2]*t.dims[3];if(!this.drawBitmap||this.drawBitmap.length!==i){F.debug("bitmap dims are wrong");return}const r=e.createFramebuffer();e.bindFramebuffer(e.FRAMEBUFFER,r),e.disable(e.CULL_FACE),e.viewport(0,0,this.back.dims[1],this.back.dims[2]),e.disable(e.BLEND);let s=C0(this.back);const n=this.r16Tex(null,$.TEXTURE11_GC_BACK,this.back.dims,s);for(let v=1;v<i;v++)s[v]=this.drawBitmap[v];const a=this.r16Tex(null,$.TEXTURE14_GC_LABEL0,this.back.dims,s),o=this.r16Tex(null,$.TEXTURE15_GC_LABEL1,this.back.dims,s),l=1e4;for(let v=1;v<i;v++)s[v]>0&&(s[v]=l);const c=this.r16Tex(null,$.TEXTURE12_GC_STRENGTH0,this.back.dims,s),h=this.r16Tex(null,$.TEXTURE13_GC_STRENGTH1,this.back.dims,s);e.bindVertexArray(this.genericVAO);const d=this.growCutShader;d.use(e);const f=128;e.uniform1i(d.uniforms.finalPass,0),e.uniform1i(d.uniforms.backTex,11);for(let v=0;v<f;v++){e.uniform1i(d.uniforms.labelTex,14),e.uniform1i(d.uniforms.strengthTex,12);for(let b=0;b<this.back.dims[3];b++){const w=1/this.back.dims[3]*(b+.5);e.uniform1f(d.uniforms.coordZ,w),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,o,0,b),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT1,h,0,b),e.drawBuffers([e.COLOR_ATTACHMENT0,e.COLOR_ATTACHMENT1]),e.checkFramebufferStatus(e.FRAMEBUFFER)!==e.FRAMEBUFFER_COMPLETE&&F.error("Incomplete framebuffer"),e.drawArrays(e.TRIANGLE_STRIP,0,4)}v===f-1&&e.uniform1i(d.uniforms.finalPass,1),e.uniform1i(d.uniforms.labelTex,15),e.uniform1i(d.uniforms.strengthTex,13);for(let b=0;b<this.back.dims[3];b++){const w=1/this.back.dims[3]*(b+.5);e.uniform1f(d.uniforms.coordZ,w),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,a,0,b),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT1,c,0,b),e.drawBuffers([e.COLOR_ATTACHMENT0,e.COLOR_ATTACHMENT1]),e.checkFramebufferStatus(e.FRAMEBUFFER)!==e.FRAMEBUFFER_COMPLETE&&F.error("Incomplete framebuffer"),e.drawArrays(e.TRIANGLE_STRIP,0,4)}}e.drawBuffers([e.COLOR_ATTACHMENT0]);const u=e.COLOR_ATTACHMENT1,m=a;e.readBuffer(u);const p=e.getParameter(e.IMPLEMENTATION_COLOR_READ_FORMAT),g=e.getParameter(e.IMPLEMENTATION_COLOR_READ_TYPE);(p!==e.RED_INTEGER||g!==e.SHORT)&&F.debug("readPixels will fail."),s=new Int16Array;const x=this.back.dims[1]*this.back.dims[2],A=new Int16Array(x);for(let v=0;v<this.back.dims[3];v++)e.framebufferTextureLayer(e.FRAMEBUFFER,u,m,0,v),e.readPixels(0,0,this.back.dims[1],this.back.dims[2],p,g,A),s=Int16Array.from([...s,...A]);let y=s[0];for(let v=0;v<s.length;v++)y=Math.max(y,s[v]);for(let v=1;v<i;v++)this.drawBitmap[v]=s[v];e.deleteTexture(n),e.deleteTexture(c),e.deleteTexture(h),e.deleteTexture(a),e.deleteTexture(o),e.bindVertexArray(this.unusedVAO),e.viewport(0,0,e.canvas.width,e.canvas.height),e.bindFramebuffer(e.FRAMEBUFFER,null),e.deleteFramebuffer(r),this.drawAddUndoBitmap(),this.refreshDrawing(!0)}drawPt(t,e,i,r,s=null){const n=s??this.drawBitmap;if(!n)throw new Error("drawBitmap not set");if(!this.back?.dims)throw new Error("back.dims not set");gt({x:t,y:e,z:i,penValue:r,drawBitmap:n,dims:this.back.dims,penSize:this.opts.penSize,penAxCorSag:this.drawPenAxCorSag})}drawPenLine(t,e,i){if(!this.drawBitmap)throw new Error("drawBitmap not set");if(!this.back?.dims)throw new Error("back.dims not set");H2({ptA:t,ptB:e,penValue:i,drawBitmap:this.drawBitmap,dims:this.back.dims,penSize:this.opts.penSize,penAxCorSag:this.drawPenAxCorSag})}drawRectangleMask(t,e,i){if(!this.drawBitmap)throw new Error("drawBitmap not set");if(!this.back?.dims)throw new Error("back.dims not set");_2({ptA:t,ptB:e,penValue:i,drawBitmap:this.drawBitmap,dims:this.back.dims,penSize:this.opts.penSize,penAxCorSag:this.drawPenAxCorSag})}drawEllipseMask(t,e,i){if(!this.drawBitmap)throw new Error("drawBitmap not set");if(!this.back?.dims)throw new Error("back.dims not set");J2({ptA:t,ptB:e,penValue:i,drawBitmap:this.drawBitmap,dims:this.back.dims,penSize:this.opts.penSize,penAxCorSag:this.drawPenAxCorSag})}drawingBinaryDilationWithSeed(t,e=6){try{let i=function(g){return g[0]+g[1]*o+g[2]*l};const r=this.drawBitmap,s=this.back.dims[1],n=this.back.dims[2],a=this.back.dims[3],o=s,l=s*n,c=l*a,h=i(t);if(h<0||h>=c)throw new Error("Seed index is out of bounds.");const d=r[h];if(d===0)throw new Error("Seed voxel is not part of a filled cluster.");const f=r.slice();for(let g=0;g<c;g++)f[g]=f[g]===d?1:0;this.drawFloodFillCore(f,h,e);const u=r.slice(),m=[],p=[-l,l,-s,s,-1,1];m.push(...p),e>6&&m.push(-s-1,-s+1,s-1,s+1,-l-s,-l+s,-l-1,-l+1,l-s,l+s,l-1,l+1),e>18&&m.push(-l-s-1,-l-s+1,-l+s-1,-l+s+1,l-s-1,l-s+1,l+s-1,l+s+1);for(let g=0;g<c;g++)if(f[g]===2){const x=g%s,A=Math.floor(g%l/s),y=Math.floor(g/l);for(const v of m){const b=g+v;if(b<0||b>=c)continue;const w=b%s,C=Math.floor(b%l/s),M=Math.floor(b/l);Math.abs(w-x)>1||Math.abs(C-A)>1||Math.abs(M-y)>1||r[b]===0&&(u[b]=d)}}this.drawBitmap=u,this.drawAddUndoBitmap(),this.refreshDrawing(!0)}catch(i){F.error("Error in drawingBinaryDilationWithSeed:",i)}}drawFloodFillCore(t,e,i=6){if(!this.back?.dims)throw new Error("back.dims undefined");const r=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];im({img:t,seedVx:e,dims:r,neighbors:i})}drawFloodFill(t,e=0,i=0,r=NaN,s=NaN,n=6,a=Number.POSITIVE_INFINITY,o=!1,l=null,c=!1){if(!this.drawBitmap&&(F.warn("drawFloodFill called without an initialized drawBitmap."),this.createEmptyDrawing(),!this.drawBitmap)){F.error("Failed to create drawing bitmap.");return}if(this.clickToSegmentIsGrowing&&!this.clickToSegmentGrowingBitmap){if(F.warn("drawFloodFill called in preview mode without initialized clickToSegmentGrowingBitmap."),this.drawBitmap)this.clickToSegmentGrowingBitmap=this.drawBitmap.slice();else{F.error("Cannot initialize growing bitmap as drawBitmap is null.");return}if(!this.clickToSegmentGrowingBitmap){F.error("Failed to create growing bitmap.");return}}if(l===null&&(l=this.drawBitmap),!l){F.error("drawFloodFill targetBitmap is null.");return}if(!this.back?.dims)throw new Error("back.dims undefined");e=Math.abs(e);const h=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];if(!lm(t,h))return;const d=ua(h),{nxyz:f}=d,u=this.clickToSegmentIsGrowing?this.drawBitmap:l;if(!u){F.error("Could not determine original bitmap state.");return}const m=new Uint8Array(f).fill(0),p=tm(o,this.drawPenAxCorSag),g=d.vx2xyz,x=d.xyz2vx,A=T=>this.vox2mm(T,this.back.matRAS),y=A(t),v=a**2;function b(T){const E=g(T);if(p>=0&&E[p]!==t[p])return!1;const I=A(E);return(I[0]-y[0])**2+(I[1]-y[1])**2+(I[2]-y[2])**2<=v}const w=x(t),C=u[w];if(c&&!cm(C)){F.debug("Grow/Erase Cluster tool requires starting on a masked voxel."),this.clickToSegmentIsGrowing&&this.clickToSegmentGrowingBitmap&&this.drawBitmap&&(this.clickToSegmentGrowingBitmap.set(this.drawBitmap),this.refreshDrawing(!0,!0));return}if(i===0&&C===e&&!c&&e!==0&&(F.debug("drawFloodFill selected voxel is already desired color"),!this.clickToSegmentIsGrowing))return;let M=NaN;if(c&&(i===Number.POSITIVE_INFINITY||i===Number.NEGATIVE_INFINITY)){const T=u.slice();for(let U=0;U<f;U++)T[U]=T[U]===C&&b(U)?1:0;if(T[w]!==1){F.error("Seed voxel could not be marked for cluster ID.");return}this.drawFloodFillCore(T,w,n);const E=this.volumes[0].img2RAS();M=om({clusterImg:T,backImg:E,nxyz:f,fallbackIntensity:E[w]}),F.debug(`Grow Cluster using mean intensity: ${M.toFixed(2)} voxels.`);const[I,S]=zs(i,M,NaN,NaN);for(let U=0;U<f;U++)if(T[U]===2)m[U]=1;else if(u[U]===0){const B=E[U];B>=I&&B<=S&&b(U)&&(m[U]=1)}e=C}else if(i===0)if(c&&e===0){F.debug(`Erase Cluster: Identifying cluster with color ${C}`);for(let T=0;T<f;T++)m[T]=u[T]===C&&b(T)?1:0}else for(let T=0;T<f;T++)u[T]===C&&b(T)&&C!==0&&(m[T]=1);else{const T=this.volumes[0].img2RAS();M=T[w];const[E,I]=zs(i,M,r,s);for(let S=0;S<f;S++){const U=T[S];U>=E&&U<=I&&b(S)&&(m[S]=1)}e=u[w],e===0&&(e=this.opts.penValue,(e<1||!isFinite(e))&&(e=1))}if(m[w]!==1)if(hm(C,e,c,i)&&b(w))m[w]=1,F.debug("Forcing seed voxel to 1 in working buffer.");else{F.debug("Seed voxel not marked as candidate '1' and not valid originally."),this.clickToSegmentIsGrowing&&this.clickToSegmentGrowingBitmap&&this.drawBitmap&&this.clickToSegmentGrowingBitmap.set(this.drawBitmap);return}this.drawFloodFillCore(m,w,n),dm({img:m,targetBitmap:l,originalBitmap:u,newColor:e,nxyz:f,isPreviewMode:this.clickToSegmentIsGrowing&&l===this.clickToSegmentGrowingBitmap}),this.clickToSegmentIsGrowing?this.refreshDrawing(!0,!0):(this.drawAddUndoBitmap(),this.refreshDrawing(!0,!1))}floodFillSectionFIFO(t,e,i,r){da({img2D:t,dims2D:e,minPt:i,maxPt:r})}drawPenFilled(){if(this.drawPenFillPts.length<2){this.drawPenFillPts=[];return}if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(!this.back?.dims)throw new Error("back.dims undefined");const t=this.drawUndoBitmaps[this.currentDrawUndoBitmap]?.length>0?this.drawUndoBitmaps[this.currentDrawUndoBitmap]:null,e=Q2({penFillPts:this.drawPenFillPts,penAxCorSag:this.drawPenAxCorSag,drawBitmap:this.drawBitmap,dims:this.back.dims,penValue:this.opts.penValue,fillOverwrites:this.drawFillOverwrites,currentUndoBitmap:t});e.success&&(this.drawBitmap=e.drawBitmap),this.drawPenFillPts=[],this.drawAddUndoBitmap(),this.refreshDrawing(!1),this._emitEvent("drawingChanged",{action:"draw"}),this.onDrawingChanged("draw")}blurDrawingGL(t){const e=this.gl,i=this.blurShader;if(!i||!this.drawTexture)return;const r=Math.max(1,Math.round(this.opts.smoothDrawing));this.drawSmoothedTexture=qc(e,this.drawSmoothedTexture,$.TEXTURE10_DRAW_SMOOTH,t);const s=$.TEXTURE11_GC_BACK,n=11;e.bindVertexArray(this.genericVAO);const a=e.createFramebuffer();e.bindFramebuffer(e.FRAMEBUFFER,a),e.viewport(0,0,t[1],t[2]),e.disable(e.BLEND),i.use(e),e.activeTexture(s),e.bindTexture(e.TEXTURE_3D,this.drawTexture),e.uniform1i(i.uniforms.intensityVol,n),e.uniform1f(i.uniforms.dX,1/t[1]),e.uniform1f(i.uniforms.dY,1/t[2]),e.uniform1f(i.uniforms.dZ,1/t[3]),e.uniform1i(i.uniforms.kernelRadius,r),e.uniform1i(i.uniforms.binarize,1);for(let o=0;o<t[3];o++)e.uniform1f(i.uniforms.coordZ,(o+.5)/t[3]),e.framebufferTextureLayer(e.FRAMEBUFFER,e.COLOR_ATTACHMENT0,this.drawSmoothedTexture,0,o),e.drawArrays(e.TRIANGLE_STRIP,0,4);e.deleteFramebuffer(a),e.bindFramebuffer(e.FRAMEBUFFER,null),e.bindVertexArray(this.unusedVAO)}closeDrawing(){this.drawClearAllUndoBitmaps(),this.drawTexture=this.rgbaTex(this.drawTexture,$.TEXTURE7_DRAW,[2,2,2,2],!0),this.drawSmoothedTexture&&(this.gl.deleteTexture(this.drawSmoothedTexture),this.drawSmoothedTexture=null),this.drawBitmap=null,this.clickToSegmentGrowingBitmap=null,this._emitEvent("drawingChanged",{action:"close"}),this.onDrawingChanged("close"),this.drawScene()}refreshDrawing(t=!0,e=!1){const i=Y2({useClickToSegmentBitmap:e,drawingEnabled:this.opts.drawingEnabled,clickToSegment:this.opts.clickToSegment,drawBitmap:this.drawBitmap,clickToSegmentGrowingBitmap:this.clickToSegmentGrowingBitmap});i.warning&&F.warn(`refreshDrawing: ${i.warning}`);const r=i.bitmapDataSource;if(!this.back?.dims){F.warn("refreshDrawing: back.dims undefined, cannot refresh drawing texture yet.");return}const s=Wi(this.back.dims);if(!r){F.warn(`refreshDrawing: Bitmap data source (${i.useClickToSegmentBitmap?"growing":"main"}) is null. Cannot update texture.`),t&&this.drawScene();return}const n=W2(r.length,this.back.dims.slice());if(K2(r.length,s)||F.warn(`Drawing bitmap length (${r.length}) must match the background image (${s})`),this.gl.activeTexture($.TEXTURE7_DRAW),this.opts.is2DSliceShader){const o=this.frac2vox(this.scene.crosshairPos),l=Math.min(Math.max(o[2],0),n[3]-1),c=n[1]*n[2],h=l*c;F.debug(`refresh huge 2D drawing x×y×z ${n[1]}×${n[2]}×${n[3]} slice ${h}`);const d=r.subarray(h,h+c);this.gl.bindTexture(this.gl.TEXTURE_2D,this.drawTexture),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,n[1],n[2],this.gl.RED,this.gl.UNSIGNED_BYTE,d)}else this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n[1],n[2],n[3],this.gl.RED,this.gl.UNSIGNED_BYTE,r);if(!this.drawTexture){F.error("refreshDrawing: drawTexture (GPU texture) is null.");return}const a=r.some(o=>o!==0);this.opts.smoothDrawing>0&&!this.opts.is2DSliceShader&&a&&this.blurDrawingGL(n),t&&this.drawScene()}closePAQD(){!this._gl||!this.paqdTexture||(this.paqdTexture=this.rgbaTex(this.paqdTexture,$.TEXTURE8_PAQD,[2,2,2,2],!0))}r8Tex2D(t,e,i,r=!1){if(t&&this.gl.deleteTexture(t),t=this.gl.createTexture(),this.gl.activeTexture(e),this.gl.bindTexture(this.gl.TEXTURE_2D,t),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.R8,i[1],i[2]),r){const s=new Uint8Array(i[1]*i[2]);this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,i[1],i[2],this.gl.RED,this.gl.UNSIGNED_BYTE,s)}return t}initFontMets(){if(!this.fontMetrics)throw new Error("fontMetrics undefined");this.fontMets={distanceRange:this.fontMetrics.atlas.distanceRange,size:this.fontMetrics.atlas.size,mets:{}};const t=this.fontMetrics.atlas.width,e=this.fontMetrics.atlas.height;for(let i=0;i<this.fontMetrics.glyphs.length;i++){const r=this.fontMetrics.glyphs[i],s=r.unicode;if(this.fontMets.mets[s]||(this.fontMets.mets[s]={xadv:0,uv_lbwh:[0,0,0,0],lbwh:[0,0,0,0]}),this.fontMets.mets[s].xadv=r.advance,r.planeBounds===void 0)continue;let n=r.atlasBounds.left/t,a=(e-r.atlasBounds.top)/e,o=(r.atlasBounds.right-r.atlasBounds.left)/t,l=(r.atlasBounds.top-r.atlasBounds.bottom)/e;this.fontMets.mets[s].uv_lbwh=[n,a,o,l],n=r.planeBounds.left,a=r.planeBounds.bottom,o=r.planeBounds.right-r.planeBounds.left,l=r.planeBounds.top-r.planeBounds.bottom,this.fontMets.mets[s].lbwh=[n,a,o,l]}}async loadFont(t=fs,e=us){if(await this.loadFontTexture(t),typeof e=="string"){const i=await fetch(e);if(!i.ok)throw Error(i.statusText);this.fontMetrics=await i.json()}else this.fontMetrics=e;this.initFontMets(),this.fontShader.use(this.gl),this.drawScene()}async loadDefaultMatCap(){return this.loadMatCapTexture(Gc)}async loadDefaultFont(){await this.loadFontTexture(this.DEFAULT_FONT_GLYPH_SHEET),this.fontMetrics=this.DEFAULT_FONT_METRICS,this.initFontMets()}async initText(){this.fontShader=new ee(this.gl,j0,_0),this.fontShader.use(this.gl),await this.loadDefaultFont(),await this.loadDefaultMatCap(),this.drawLoadingText(this.opts.loadingText)}meshShaderNameToNumber(t="Phong"){return Hn(t,this.meshShaders)}setMeshShader(t,e=2){const i=Gf({meshes:this.meshes,meshShaders:this.meshShaders,id:t,meshShaderNameOrNumber:e,meshShaderNameToNumber:this.meshShaderNameToNumber.bind(this)});i!==null&&(this.updateGLVolume(),this._emitEvent("meshShaderChanged",{meshIndex:i.meshIndex,shaderIndex:i.shaderIndex}),this.onMeshShaderChanged(i.meshIndex,i.shaderIndex))}createCustomMeshShader(t,e="Custom"){return Nd({gl:this.gl,fragmentShaderText:t,name:e,meshShaders:this.meshShaders})}setCustomSliceShader(t=""){this.customSliceShader=Pd({gl:this.gl,fragmentShaderText:t,drawOpacity:this.drawOpacity,customSliceShader:this.customSliceShader}),this.updateGLVolume()}setCustomMeshShader(t="",e="Custom"){const i=this.createCustomMeshShader(t,e);return this.meshShaders.push(i),this._emitEvent("customMeshShaderAdded",{fragmentShaderText:t,name:e}),this.onCustomMeshShaderAdded(t,e),this.meshShaders.length-1}async setCustomMeshShaderFromUrl(t,e=""){try{const i=await fetch(t);if(!i.ok)throw new Error(`Failed to fetch shader from ${t}: ${i.status} ${i.statusText}`);const r=await i.text();return(!e||e.trim()==="")&&(e=(t.split("/").pop()??t).split("?")[0].split("#")[0].replace(/\.[^/.]+$/,"")),this.setCustomMeshShader(r,e)}catch(i){throw new Error(`setCustomMeshShaderFromUrl(${t}) failed: ${i.message}`)}}meshShaderNames(t=!0){return Ld(this.meshShaders,t)}initRenderShader(t,e=0){It({gl:this.gl,shader:t,gradientAmount:e,renderDrawAmbientOcclusion:this.renderDrawAmbientOcclusion,renderSilhouette:this.opts.renderSilhouette,gradientOpacity:this.opts.gradientOpacity})}async init(){const t=this.gl.getExtension("WEBGL_debug_renderer_info");if(t){const d=this.gl.getParameter(t.UNMASKED_VENDOR_WEBGL),f=this.gl.getParameter(t.UNMASKED_RENDERER_WEBGL);F.info("renderer vendor: ",d),F.info("renderer: ",f)}else F.info("debug_renderer_info unavailable");const e=this.gl.getParameter(this.gl.RENDERER);F.info("firefox renderer: ",e),this.gl.enable(this.gl.CULL_FACE),this.gl.cullFace(this.gl.FRONT),this.gl.enable(this.gl.BLEND),this.gl.blendFunc(this.gl.SRC_ALPHA,this.gl.ONE_MINUS_SRC_ALPHA),this.volumeTexture=this.rgbaTex(this.volumeTexture,$.TEXTURE0_BACK_VOL,[2,2,2,2],!0),this.overlayTexture=this.rgbaTex(this.overlayTexture,$.TEXTURE2_OVERLAY_VOL,[2,2,2,2],!0),this.drawTexture=this.r8Tex(this.drawTexture,$.TEXTURE7_DRAW,[2,2,2,2],!0),this.paqdTexture=this.rgbaTex(this.paqdTexture,$.TEXTURE8_PAQD,[2,2,2,2],!0);const i=[1,1,0,1,0,0,0,1,0,0,0,0],r=this.gl;this.cuboidVertexBuffer=r.createBuffer(),r.bindBuffer(r.ARRAY_BUFFER,this.cuboidVertexBuffer),r.bufferData(r.ARRAY_BUFFER,new Float32Array(i),r.STATIC_DRAW),this.genericVAO=r.createVertexArray(),r.bindVertexArray(this.genericVAO),r.bindBuffer(r.ARRAY_BUFFER,this.cuboidVertexBuffer),r.enableVertexAttribArray(0),r.vertexAttribPointer(0,3,r.FLOAT,!1,0,0),r.bindVertexArray(this.unusedVAO),this.pickingMeshShader=new ee(r,Pr,cd),this.pickingMeshShader.use(r),this.pickingImageShader=Hd(r);const s=kd(r,this.drawOpacity);this.slice2DShader=s.slice2DShader,this.sliceMMShader=s.sliceMMShader,this.sliceV1Shader=s.sliceV1Shader;const n=Od(r,gl,this.unusedVAO);this.orientCubeShader=n.shader,this.orientCubeShaderVAO=n.vao;const a=zd(r);this.rectShader=a.rectShader,this.rectOutlineShader=a.rectOutlineShader,this.lineShader=a.lineShader,this.line3DShader=a.line3DShader,this.circleShader=a.circleShader;const o=Gd({gl:r,renderDrawAmbientOcclusion:this.renderDrawAmbientOcclusion,renderSilhouette:this.opts.renderSilhouette,gradientOpacity:this.opts.gradientOpacity});this.renderVolumeShader=o.renderVolumeShader,this.renderSliceShader=o.renderSliceShader,this.renderGradientShader=o.renderGradientShader,this.renderGradientValuesShader=o.renderGradientValuesShader,this.renderShader=o.renderShader,this.colorbarShader=Yd(r);const l=Xd(r);this.blurShader=l.blurShader,this.gradientPrePassShader=l.gradientPrePassShader,this.sobelFirstOrderShader=l.sobelFirstOrderShader,this.sobelSecondOrderShader=l.sobelSecondOrderShader,this.growCutShader=l.growCutShader,this.passThroughShader=l.passThroughShader;const c=Wd(r);this.orientShaderAtlasU=c.orientShaderAtlasU,this.orientShaderAtlasI=c.orientShaderAtlasI,this.orientShaderU=c.orientShaderU,this.orientShaderI=c.orientShaderI,this.orientShaderF=c.orientShaderF,this.orientShaderRGBU=c.orientShaderRGBU,this.orientShaderPAQD=c.orientShaderPAQD;const h=Kd(r);return this.surfaceShader=h.surfaceShader,this.fiberShader=h.fiberShader,this.pickingImageShader.use(r),qd(r,this.meshShaders),this.bmpShader=new ee(r,Q0,Z0),await this.initText(),this.opts.thumbnail.length>0&&(await this.loadBmpTexture(this.opts.thumbnail),this.thumbnailVisible=!0),this.updateGLVolume(),this.initialized=!0,this.resizeListener(),this.drawScene(),this}gradientGL(t){this.gradientTexture=Es({gl:this.gl,hdr:t,genericVAO:this.genericVAO,unusedVAO:this.unusedVAO,volumeTexture:this.volumeTexture,paqdTexture:this.paqdTexture,gradientTexture:this.gradientTexture,gradientOrder:this.opts.gradientOrder,blurShader:this.blurShader,gradientPrePassShader:this.gradientPrePassShader,sobelFirstOrderShader:this.sobelFirstOrderShader,sobelSecondOrderShader:this.sobelSecondOrderShader,rgbaTex:this.rgbaTex.bind(this)})}getGradientTextureData(){return eu({gl:this.gl,gradientTexture:this.gradientTexture,dims:this.back?.dims??null})}setCustomGradientTexture(t,e){const i=tu({gl:this.gl,data:t,dims:e,backDims:this.back?.dims??null,gradientTexture:this.gradientTexture,gradientTextureAmount:this.gradientTextureAmount,hdr:this.back?.hdr??null,gradientGLFn:this.gradientGL.bind(this)});this.gradientTexture=i.gradientTexture,this.useCustomGradientTexture=i.useCustomGradientTexture,t!==null&&i.useCustomGradientTexture&&this.drawScene()}updateGLVolume(){let t=0;const e=this.volumes.length;this.refreshColormaps(),this.closePAQD();for(let i=0;i<e;i++)this.volumes[i].toRAS&&(this.refreshLayers(this.volumes[i],t),t++);if(this.furthestVertexFromOrigin=0,e>0&&(this.furthestVertexFromOrigin=this.volumeObject3D?.furthestVertexFromOrigin??0),this.meshes)for(let i=0;i<this.meshes.length;i++)this.furthestVertexFromOrigin=Math.max(this.furthestVertexFromOrigin,this.meshes[i].furthestVertexFromOrigin);this._emitEvent("volumeUpdated",void 0),this.onVolumeUpdated&&this.onVolumeUpdated(),this.drawScene()}getDescriptives(t){const{layer:e=0,masks:i=[],drawingIsMask:r=!1,roiIsMask:s=!1,startVox:n=[0,0,0],endVox:a=[0,0,0]}=t,o=this.volumes[e].hdr,l=this.volumes[e].pixDimsRAS,c=isNaN(o.scl_slope)?1:o.scl_slope,h=isNaN(o.scl_inter)?1:o.scl_inter,d=this.volumes[e].img,f=d.length,u=Tm(d,c,h),m=i.filter(A=>{const y=this.volumes[A].img.length===f;return y||F.debug("Mask resolution does not match image. Skipping masking layer "+A),y}).map(A=>this.volumes[A].img),{mask:p,area:g}=Mm({nv:f,maskImages:m.length>0?m:void 0,drawBitmap:this.drawBitmap,drawingIsMask:i.length<1&&r,roiIsMask:i.length<1&&s,startVox:n,endVox:a,hdr:o,pixDimsRAS:l}),x=Dm(u,p);return{...x,volumeMM3:x.nvox*o.pixDims[1]*o.pixDims[2]*o.pixDims[3],volumeML:x.nvox*o.pixDims[1]*o.pixDims[2]*o.pixDims[3]*.001,cal_min:this.volumes[e].cal_min,cal_max:this.volumes[e].cal_max,robust_min:this.volumes[e].robust_min,robust_max:this.volumes[e].robust_max,area:g}}refreshLayers(t,e){if(this.volumes.length<1)return;this.refreshColormaps();const i=t.hdr,r=of(t),s=t.opacity;if(e>1&&s===0)return;let n=null;if(!this.back)throw new Error("back undefined");this.gl.bindVertexArray(this.unusedVAO),this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN);let a=de(t.toRAS);if(e===0){this.volumeObject3D=mf({overlayItem:t,VOLUME_ID:this.VOLUME_ID,gl:this.gl}),Se(a,a),this.back.matRAS=t.matRAS,this.back.dims=t.dimsRAS,this.back.pixDims=t.pixDimsRAS;const{volScale:x,vox:A}=this.sliceScale(!0);this.volScale=x,this.vox=A,this.volumeObject3D.scale=Array.from(x);const{isAboveMax2D:y,isAboveMax3D:v}=lf({hdr:i,max2D:this.uiData.max2D,max3D:this.uiData.max3D});if(y&&F.error("Image dimensions exceed maximum texture size of hardware."),i.datatypeCode===2304&&i.dims[3]<2){F.info(`RGBA 2D image (${i.dims[1]}×${i.dims[2]}) using Texture2D`),this.opts.is2DSliceShader=!0,this.volumeTexture=this.rgbaTex2D(this.volumeTexture,$.TEXTURE0_BACK_VOL,t.dimsRAS,r,!1);return}if(v){F.info(`Large scalar image (>${this.uiData.max3D}) requires Texture2D (${i.dims[1]}×${i.dims[2]}×${i.dims[3]})`);const w=i.dims[1]*i.dims[2],C=this.frac2vox(this.scene.crosshairPos),T=Math.min(Math.max(C[2],0),i.dims[3]-1)*w,E=new Uint8Array(w*4),I=new Uint32Array(E.buffer),S=Math.floor(t.opacity*255),U=255*i.scl_slope/(t.cal_max-t.cal_min),B=255*(i.scl_inter-t.cal_min)/(t.cal_max-t.cal_min),V=new Uint8Array(this.colormap(t.colormap)),R=new Uint32Array(V.buffer);let P=-1;for(let L=0;L<w;L++){const N=r[L+T]*U+B,Y=Math.round(Math.min(255,Math.max(0,N)));I[L]=R[Y],E[P+=4]=S}this.opts.is2DSliceShader=!0,n=this.rgbaTex2D(this.volumeTexture,$.TEXTURE0_BACK_VOL,t.dimsRAS,E,!1);return}if(v&&F.warn(`dimensions exceed 3D limits ${i.dims}`),this.opts.is2DSliceShader=!1,n=this.rgbaTex(this.volumeTexture,$.TEXTURE0_BACK_VOL,t.dimsRAS),!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl),this.gl.uniform3fv(this.renderShader.uniforms.texVox,this.vox),this.gl.uniform3fv(this.renderShader.uniforms.volScale,this.volScale);const b=this.pickingImageShader;b.use(this.gl),this.gl.uniform1i(b.uniforms.volume,0),this.gl.uniform1i(b.uniforms.colormap,1),this.gl.uniform1i(b.uniforms.overlay,2),this.gl.uniform3fv(b.uniforms.volScale,this.volScale),F.debug(this.volumeObject3D)}else this.back?.dims===void 0&&F.error("Fatal error: Unable to render overlay: background dimensions not defined!"),a=pf({overlayItem:t,mm2frac:this.mm2frac.bind(this)}),e===1?(n=gf({gl:this.gl,layer:e,backDims:this.back.dims,rgbaTex:this.rgbaTex.bind(this)}).overlayTexture,this.overlayTexture=n,this.overlayTextureID=n):n=this.overlayTextureID;const o=Af(this.gl);this.gl.viewport(0,0,this.back.dims[1],this.back.dims[2]);const l=Mf({gl:this.gl,TEXTURE9_ORIENT:$.TEXTURE9_ORIENT});if(!i)throw new Error("hdr undefined");if(!r)throw new Error("img undefined");let c=this.orientShaderU;if(i.datatypeCode===2304){const x=Rf({gl:this.gl,hdr:i,img:r,overlayItem:t,layer:e,orientShaderRGBU:this.orientShaderRGBU,orientShaderPAQD:this.orientShaderPAQD,volumes:this.volumes,backDims:this.back.dims,rgbaTex:this.rgbaTex.bind(this),paqdTexture:this.paqdTexture,TEXTURE8_PAQD:$.TEXTURE8_PAQD,TEXTURE9_ORIENT:$.TEXTURE9_ORIENT});c=x.orientShader,x.outTexture!==null&&(n=x.outTexture),x.paqdTexture!==null&&(this.paqdTexture=x.paqdTexture)}else c=Uf({gl:this.gl,hdr:i,img:r,orientShaderU:this.orientShaderU,orientShaderI:this.orientShaderI,orientShaderF:this.orientShaderF,orientShaderRGBU:this.orientShaderRGBU,orientShaderAtlasU:this.orientShaderAtlasU,orientShaderAtlasI:this.orientShaderAtlasI}).orientShader;t.global_min===void 0&&t.calMinMax(),this.gl.bindVertexArray(this.genericVAO);const h=xf({gl:this.gl,layer:e,backDims:this.back.dims,rgbaTex:this.rgbaTex.bind(this),passThroughShader:this.passThroughShader});c.use(this.gl),this.gl.activeTexture($.TEXTURE1_COLORMAPS);const{colormapLabelTexture:d}=cf({gl:this.gl,overlayItem:t,orientShader:c,createColormapTexture:this.createColormapTexture.bind(this)});if(d===null&&(this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.uniform1f(c.uniforms.cal_min,t.cal_min),this.gl.uniform1f(c.uniforms.cal_max,t.cal_max)),"alphaThreshold"in t&&(F.warn("alphaThreshold is deprecated: use colormapType"),t.alphaThreshold===!0&&(t.colormapType=2),t.alphaThreshold===!1&&(t.colormapType=1),delete t.alphaThreshold),!c)throw new Error("orientShader undefined");vf({gl:this.gl,overlayItem:t,orientShader:c,layer:e,isAdditiveBlend:this.opts.isAdditiveBlend});const{modulateTexture:f}=hf({gl:this.gl,overlayItem:t,hdr:i,volumes:this.volumes,orientShader:c,r8Tex:this.r8Tex.bind(this),TEXTURE7:this.gl.TEXTURE7});if(this.gl.activeTexture($.TEXTURE9_ORIENT),this.gl.bindTexture(this.gl.TEXTURE_3D,l),!this.back.dims)throw new Error("back.dims undefined");if(wf({gl:this.gl,orientShader:c,backDims:this.back.dims,outTexture:n,mtx:a,hdr:i,intensityVolTextureUnit:9,blendTextureUnit:10,colormapTextureUnit:1,modulationTextureUnit:7,opacity:s,atlasOutline:this.opts.atlasOutline,atlasActiveIndex:this.opts.atlasActiveIndex}),F.debug("back dims: ",this.back.dims),this.gl.bindVertexArray(this.unusedVAO),this.gl.deleteTexture(l),this.gl.deleteTexture(f),this.gl.deleteTexture(h),this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,null),this.gl.deleteFramebuffer(o),e===0&&(this.volumeTexture=n,this.gradientTexture=Es({gl:this.gl,hdr:i,genericVAO:this.genericVAO,unusedVAO:this.unusedVAO,volumeTexture:this.volumeTexture,paqdTexture:this.paqdTexture,gradientTexture:this.gradientTexture,gradientOrder:this.opts.gradientOrder,blurShader:this.blurShader,gradientPrePassShader:this.gradientPrePassShader,sobelFirstOrderShader:this.sobelFirstOrderShader,sobelSecondOrderShader:this.sobelSecondOrderShader,rgbaTex:this.rgbaTex.bind(this)})),!this.renderShader)throw new Error("renderShader undefined");if(!this.pickingImageShader)throw new Error("pickingImageShader undefined");const u=this.sliceScale(!0),m=u.vox,p=u.volScale,g=bf({is2DSliceShader:this.opts.is2DSliceShader,isV1SliceShader:this.opts.isV1SliceShader,sliceMMShader:this.sliceMMShader,slice2DShader:this.slice2DShader,sliceV1Shader:this.sliceV1Shader,customSliceShader:this.customSliceShader});yf({gl:this.gl,renderShader:this.renderShader,pickingImageShader:this.pickingImageShader,sliceShader:g,overlaysLength:this.overlays.length,clipPlaneColor:this.opts.clipPlaneColor,backOpacity:this.volumes[0].opacity,renderOverlayBlend:this.opts.renderOverlayBlend,clipPlane:this.scene.clipPlane,texVox:m,volScale:p,drawOpacity:this.drawOpacity,paqdUniforms:this.opts.paqdUniforms}),d!==null&&(this.gl.deleteTexture(d),this.gl.activeTexture($.TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture)),Cf({gl:this.gl,shader:g,is2DSliceShader:this.opts.is2DSliceShader,drawTexture:this.drawTexture,paqdTexture:this.paqdTexture,TEXTURE7_DRAW:$.TEXTURE7_DRAW,TEXTURE8_PAQD:$.TEXTURE8_PAQD}),this.updateInterpolation(e)}colormaps(){return re.colormaps()}addColormap(t,e){re.addColormap(t,e)}setColormap(t,e){const i=this.getVolumeIndexByID(t);this.volumes[i].colormap=e,this.updateGLVolume()}idx(t,e,i,r){return pe(t,e,i,r)}check_previous_slice(t,e,i,r,s,n,a,o){return ma(t,e,i,r,s,n,a,o)}do_initial_labelling(t,e,i){const r=pa(t,e,i);return[r.labelCount,r.translationTable,r.initialLabels]}fill_tratab(t,e,i){Kr(t,e,i)}translate_labels(t,e,i,r){const s=ga(t,e,i,r);return[s.clusterCount,s.labels]}largest_original_cluster_labels(t,e,i){const r=Aa(t,e,i);return[r.maxValue,r.voxels]}bwlabel(t,e,i=26,r=!1,s=!1){const n=xm({img:t,dim:e,conn:i,binarize:r,onlyLargestClusterPerClass:s});return[n.clusterCount,n.labels]}async createConnectedLabelImage(t,e=26,i=!1,r=!1){const s=this.getVolumeIndexByID(t),n=Uint32Array.from(this.volumes[s].dims?.slice(1,4)??[]),a=Uint32Array.from(this.volumes[s].img?.slice()??[]),[o,l]=this.bwlabel(a,n,e,i,r),c=this.volumes[s].clone();c.opacity=.5,c.colormap="random";for(let h=0;h<c.img.length;h++)c.img[h]=l[h];return c.cal_min=0,c.cal_max=o,c}async createNiftiArray(t=[256,256,256],e=[1,1,1],i=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],r=2,s=new Uint8Array){return await Me.createNiftiArray(t,e,i,r,s)}async niftiArray2NVImage(t=new Uint8Array){return await Me.loadFromUrl({url:t})}async loadFromUrl(t){return await Me.loadFromUrl({url:t})}async conform(t,e=!1,i=!0,r=!1,s=!1,n=[256,256,256],a=1,o=!1){const[l,c,h]=n,d=a,{outAffine:f,invVox2vox:u}=ym({inDims:t.hdr.dims,inAffine:t.hdr.affine.flat(),outDims:[l,c,h],outMM:d,toRAS:e}),m=new Float32Array(t.img),p=t.hdr.dims[1]*t.hdr.dims[2]*t.hdr.dims[3];if(t.hdr.scl_slope!==1||t.hdr.scl_inter!==0)for(let A=0;A<p;A++)m[A]=m[A]*t.hdr.scl_slope+t.hdr.scl_inter;const g=bm({inImg:m,inDims:t.hdr.dims,outDims:[l,c,h],invVox2vox:u,isLinear:i});let x;if(o)x=await this.createNiftiArray([l,c,h],[d,d,d],Array.from(f),16,new Uint8Array(g.buffer));else if(r){const A=s?NaN:0,y={img:t.img,dims:t.hdr.dims,global_min:t.global_min,global_max:t.global_max,datatypeCode:t.hdr.datatypeCode,scl_slope:t.hdr.scl_slope,scl_inter:t.hdr.scl_inter,cal_min:t.cal_min,cal_max:t.cal_max,f_low:A};y.dst_min=0,y.dst_max=1;const[v,b]=Gs(y),w=wm(g,0,1,v,b);x=await this.createNiftiArray([l,c,h],[d,d,d],Array.from(f),16,new Uint8Array(w.buffer))}else{const A=s?NaN:0,y={img:t.img,dims:t.hdr.dims,global_min:t.global_min,global_max:t.global_max,datatypeCode:t.hdr.datatypeCode,scl_slope:t.hdr.scl_slope,scl_inter:t.hdr.scl_inter,cal_min:t.cal_min,cal_max:t.cal_max,f_low:A};y.dst_min=0,y.dst_max=255;const[v,b]=Gs(y),w=vm(g,0,255,v,b);x=await this.createNiftiArray([l,c,h],[d,d,d],Array.from(f),2,w)}return this.niftiArray2NVImage(x)}setRenderDrawAmbientOcclusion(t){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=t,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(t,e){this.setColormap(t,e)}setColormapNegative(t,e){const i=this.getVolumeIndexByID(t);this.volumes[i].colormapNegative=e,this.updateGLVolume()}setModulationImage(t,e,i=0){const r=this.getVolumeIndexByID(t);let s=null;e.length>0&&(s=this.getVolumeIndexByID(e)),this.volumes[r].modulationImage=s,this.volumes[r].modulateAlpha=i,this.updateGLVolume()}setGamma(t=1){this.scene.gamma=t,re.gamma=t,this.updateGLVolume()}async loadDeferred4DVolumes(t){const e=this.getVolumeIndexByID(t),i=this.volumes[e];if(i.nTotalFrame4D<=i.nFrame4D)return;i.nTotalFrame4D=i.nFrame4D;let r;i.fileObject?r=await Me.loadFromFile({file:i.fileObject}):r=await Me.loadFromUrl({url:i.url}),r&&(i.img=r.img.slice(),i.nTotalFrame4D=r.nTotalFrame4D,i.nFrame4D=r.nFrame4D,this.updateGLVolume())}setFrame4D(t,e){const i=this.getVolumeIndexByID(t);if(i<0)return;const r=this.volumes[i].frame4D;sf(this.volumes,t,e),this.volumes[i].frame4D!==r&&(this.updateGLVolume(),this._emitEvent("frameChange",{volume:this.volumes[i],index:this.volumes[i].frame4D}),this.onFrameChange(this.volumes[i],this.volumes[i].frame4D),this.createOnLocationChange())}getFrame4D(t){return nf(this.volumes,t)}colormapFromKey(t){return re.colormapFromKey(t)}colormap(t="",e=!1){return re.colormap(t,e)}createColormapTexture(t=null,e=0,i=256){return t!==null&&this.gl.deleteTexture(t),e<1||i<1?null:(t=this.gl.createTexture(),this.gl.activeTexture($.TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,t),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,i,e),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),t)}addColormapList(t="",e=NaN,i=NaN,r=!1,s=!1,n=!0,a=!1){t.length<1&&(n=!1),this.colormapLists.push({name:t,min:e,max:i,isColorbarFromZero:r,negative:s,visible:n,invert:a})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const t=this.volumes.length;if(t>0)for(let n=0;n<t;n++){const a=this.volumes[n],o=Pi(a.cal_min,a.cal_max,a.cal_minNeg,a.cal_maxNeg),l=a.colormapType!==0;this.addColormapList(a.colormapNegative,o[0],o[1],l,!0,a.colorbarVisible,a.colormapInvert),this.addColormapList(a.colormap,a.cal_min,a.cal_max,l,!1,a.colorbarVisible,a.colormapInvert)}const e=this.meshes.length;if(e>0)for(let n=0;n<e;n++){const a=this.meshes[n];if(!a.colorbarVisible)continue;const o=a.layers.length,l=a.fiberColor.toLowerCase();if(a.offsetPt0&&l.startsWith("dp")){let c=null;const h=parseInt(l.substring(3));l.startsWith("dpg")&&!a.fiberGroupColormap&&(c=h<a.dpg.length?a.dpg[h]:a.dpg[0]),l.startsWith("dps")&&(c=h<a.dps.length?a.dps[h]:a.dps[0]),l.startsWith("dpv")&&(c=h<a.dpv.length?a.dpv[h]:a.dpv[0]),c&&typeof a.colormap=="string"&&this.addColormapList(a.colormap,c.cal_min,c.cal_max,!1,!1,!0,a.colormapInvert)}if("edgeColormap"in a&&"edges"in a&&a.edges!==void 0){const c=Pi(a.edgeMin,a.edgeMax,NaN,NaN);this.addColormapList(a.edgeColormapNegative,c[0],c[1],!1,!0,!0,a.colormapInvert),this.addColormapList(a.edgeColormap,a.edgeMin,a.edgeMax,!1,!1,!0,a.colormapInvert)}if(!(o<1))for(let c=0;c<o;c++){const h=this.meshes[n].layers[c];if(!h.colorbarVisible||h.colormap.length<1)continue;const d=h.colormapType!==0;if(h.useNegativeCmap){const f=Pi(h.cal_min,h.cal_max,h.cal_minNeg,h.cal_maxNeg);this.addColormapList(h.colormapNegative,f[0],f[1],d,!0,!0,h.colormapInvert)}this.addColormapList(h.colormap,h.cal_min,h.cal_max,d,!1,!0,h.colormapInvert)}}const i=this.colormapLists.length;if(i<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,i+1);let r=new Uint8ClampedArray;function s(n){const a=new Uint8ClampedArray(r.length+n.length);a.set(r),a.set(n,r.length),r=a}for(let n=0;n<i;n++)s(Array.from(this.colormap(this.colormapLists[n].name,this.colormapLists[n].invert)));return s(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,i+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,r),this}sliceScale(t=!1){if(!this.back?.dims)throw new Error("back.dims undefined");return o2({forceVox:t,getScreenFieldOfViewMM:e=>this.screenFieldOfViewMM(e),getScreenFieldOfViewVox:e=>this.screenFieldOfViewVox(e),backDims:this.back.dims})}tileIndex(t,e){return Xr({x:t,y:e,screenSlices:this.screenSlices})}inRenderTile(t,e){return H1({x:t,y:e,screenSlices:this.screenSlices})}sliceScroll3D(t=0){const e=_1({posChange:t,volumesLength:this.volumes.length,clipPlaneDepthAziElevs:this.scene.clipPlaneDepthAziElevs,activeClipPlaneIndex:this.uiData.activeClipPlaneIndex,volScaleMultiplier:this.scene.volScaleMultiplier});if(e.action!=="none"){if(e.action==="clipPlane"&&e.newClipPlaneDepth!==void 0){const i=this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex].slice();return i[0]=e.newClipPlaneDepth,this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=i,this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])}e.action==="zoom"&&e.newVolScaleMultiplier!==void 0&&(this.scene.volScaleMultiplier=e.newVolScaleMultiplier,this.drawScene())}}inGraphTile(t,e){return q1({x:t,y:e,graph:this.graph,volumesLength:this.volumes.length,firstVolumeFrameCount:this.volumes.length>0?this.volumes[0].nFrame4D??0:0})}updateBitmapFromClickToSegment(){this.clickToSegmentGrowingBitmap===null||this.drawBitmap===null||nm({sourceBitmap:this.clickToSegmentGrowingBitmap,targetBitmap:this.drawBitmap})}sumBitmap(t){return am(t)}doClickToSegment(t){const{tileIndex:e}=t;if(e<0||e>=this.screenSlices.length){F.warn(`Invalid tileIndex ${e} received in doClickToSegment.`);return}const i=this.screenSlices[e].axCorSag;if(i>2){F.warn("ClickToSegment attempted on non-2D slice tile.");return}const r=this.screenXY2TextureFrac(this.clickToSegmentXY[0],this.clickToSegmentXY[1],e,!1);if(r[0]<0){F.debug("Click location outside valid texture fraction for the tile.");return}const s=this.frac2vox(r),n=this.back.getValue(s[0],s[1],s[2]),a=rm({voxelIntensity:n,thresholdPercent:this.opts.clickToSegmentPercent,calMin:this.back.cal_min,calMax:this.back.cal_max,autoIntensity:this.opts.clickToSegmentAutoIntensity,currentIntensityMin:this.opts.clickToSegmentIntensityMin,currentIntensityMax:this.opts.clickToSegmentIntensityMax,currentBright:this.opts.clickToSegmentBright});this.opts.clickToSegmentIntensityMin=a.intensityMin,this.opts.clickToSegmentIntensityMax=a.intensityMax,this.opts.clickToSegmentBright=a.isBright;const o=sm(a.isBright);this.drawPenAxCorSag=i;const l=this.clickToSegmentIsGrowing?this.clickToSegmentGrowingBitmap:this.drawBitmap;if(!l){if(F.error("Target bitmap for flood fill is null."),this.clickToSegmentIsGrowing){if(this.drawBitmap||this.createEmptyDrawing(),!this.drawBitmap)return;this.clickToSegmentGrowingBitmap=this.drawBitmap.slice()}else if(this.createEmptyDrawing(),!this.drawBitmap)return;F.warn("Initialized missing bitmap in doClickToSegment.")}if(this.drawFloodFill([s[0],s[1],s[2]],this.opts.penValue,o,this.opts.clickToSegmentIntensityMin,this.opts.clickToSegmentIntensityMax,this.opts.floodFillNeighbors,this.opts.clickToSegmentMaxDistanceMM,this.opts.clickToSegmentIs2D,l),!this.clickToSegmentIsGrowing&&(F.debug("Applying clickToSegment mask to drawBitmap."),this.drawBitmap?(this.refreshDrawing(!1,!1),this.drawScene()):F.error("Cannot refresh drawing after click-to-segment apply, drawBitmap is null."),this.drawBitmap)){const c=this.getDescriptives({layer:0,masks:[],drawingIsMask:!0}),h={mL:c.volumeML,mm3:c.volumeMM3};this._emitEvent("clickToSegment",h),this.onClickToSegment(h)}this.createOnLocationChange(i)}mouseClick(t,e,i=0,r=!0){if(t*=this.uiData.dpr,e*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible)return this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(s=>{throw s}),!0;if(this.inGraphTile(t,e)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const s=[(t-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(e-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(s[0]>0&&s[1]>0&&s[0]<=1&&s[1]<=1){const n=Math.round(s[0]*(this.volumes[0].nFrame4D-1));return this.setFrame4D(this.volumes[0].id,n),!0}return s[0]>.5&&s[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(n=>{throw n}),!1}if(this.inRenderTile(t,e)>=0)return i===0?!1:(this.sliceScroll3D(i),this.drawScene(),!0);if(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1)return!1;for(let s=0;s<this.screenSlices.length;s++){const n=this.screenSlices[s].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==n||n>2&&!this.opts.clickToSegment&&i===0)continue;const a=this.screenXY2TextureFrac(t,e,s,!0);if(a[0]<0)continue;if(i!==0||!r){if(!r)return n<=2&&(this.scene.crosshairPos[2-n]=i,this.drawScene(),this.createOnLocationChange(n)),!0;const c=i<0?-1:1,h=[0,0,0];return n<=2&&(h[2-n]=c,this.moveCrosshairInVox(h[0],h[1],h[2])),!0}const o=this.opts.isForceMouseClickToVoxelCenters?this.vox2frac(this.frac2vox(a)):a;if(!!Ua(this.scene.crosshairPos,o)&&!this.opts.drawingEnabled)return!1;if(this.scene.crosshairPos=Ve(o),this.opts.drawingEnabled){const c=this.frac2vox(this.scene.crosshairPos);if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){let h=0,d=Math.abs(this.opts.penValue);const f=!0;return Object.is(this.opts.penValue,-0)?(h=0,d=0,F.debug("Erase Cluster selected")):(h=this.opts.penValue,F.debug("Intensity Grow selected",h)),this.drawFloodFill(c,d,h,NaN,NaN,this.opts.floodFillNeighbors,Number.POSITIVE_INFINITY,!1,this.drawBitmap,f),this.drawScene(),this.createOnLocationChange(n),!0}else{if(this.opts.clickToSegment)return n<=2&&(this.clickToSegmentIsGrowing=!1,this.doClickToSegment({x:this.clickToSegmentXY[0],y:this.clickToSegmentXY[1],tileIndex:s})),this.createOnLocationChange(n),!0;if(this.opts.penType===0){if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=n,this.drawPenFillPts=[],this.drawPt(...c,this.opts.penValue);else{if(c[0]===this.drawPenLocation[0]&&c[1]===this.drawPenLocation[1]&&c[2]===this.drawPenLocation[2])return this.drawScene(),this.createOnLocationChange(n),!0;this.drawPenLine(c,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=c,this.opts.isFilledPen&&this.drawPenFillPts.push(c),this.refreshDrawing(!1,!1)}else(this.opts.penType===1||this.opts.penType===2)&&(isNaN(this.drawShapeStartLocation[0])?(this.drawPenAxCorSag=n,this.drawShapeStartLocation=[...c],this.drawBitmap&&(this.drawShapePreviewBitmap=this.drawBitmap.slice())):this.drawShapePreviewBitmap&&this.drawBitmap&&(this.drawBitmap.set(this.drawShapePreviewBitmap),this.opts.penType===1?this.drawRectangleMask(this.drawShapeStartLocation,c,this.opts.penValue):this.opts.penType===2&&this.drawEllipseMask(this.drawShapeStartLocation,c,this.opts.penValue),this.refreshDrawing(!1,!1)))}}return this.drawScene(),this.createOnLocationChange(n),!0}return!1}drawRuler(){let t=[],e=[];for(let c=0;c<this.screenSlices.length;c++)if(this.screenSlices[c].axCorSag!==4&&this.screenSlices[c].fovMM.length>1){e=this.screenSlices[c].leftTopWidthHeight,t=this.screenSlices[c].fovMM;break}if(e.length<4)return;const[i,r,s,n]=this.getBoundsRegion(),a=Number(this.opts.rulerWidth),o=Tu({fovMM:t,ltwh:e,rulerWidth:a,regionBounds:{x:i,y:r,w:s,h:n}});if(!o)return;const l=Su(this.opts.rulerColor);this.drawRuler10cm(o.startXYendXY,l,a+1),this.drawRuler10cm(o.startXYendXY,this.opts.rulerColor,a)}drawRuler10cm(t,e,i=1){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,e),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,i),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,t),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const r=Eu(t,this.opts.rulerWidth);for(const s of r)this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,s),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(t,e,i=-1){return B0(t,e,this.screenSlices,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,isSliceMM:this.opts.isSliceMM,forceSlice:i})}dragForPanZoom(t){const i=this.getZarrVolumes().filter(a=>a.zarrHelper?.centerAtDragStart);if(i.length>0){const a=t[2]-t[0],o=t[3]-t[1];if(a===0&&o===0)return;let l=0;for(const f of this.screenSlices){if(f.axCorSag>2)continue;const u=f.leftTopWidthHeight,m=t[0],p=t[1];if(m>=u[0]&&p>=u[1]&&m<=u[0]+u[2]&&p<=u[1]+u[3]){l=f.axCorSag;break}}let c,h;l===0?(c=0,h=1):l===1?(c=0,h=2):(c=1,h=2);const d=[];for(const f of i){const u=f.zarrHelper,m=f.hdr.affine,p=[{col:0,sign:-1},{col:1,sign:-1},{col:2,sign:-1}];for(let T=0;T<3;T++){let E=0;for(let I=0;I<3;I++){const S=Math.abs(m[T][I]);S>E&&(E=S,p[T]={col:I,sign:m[T][I]<0?-1:1})}}const g=u.centerAtDragStart,x=[g.x,g.y,g.z];x[p[c].col]+=a*p[c].sign,x[p[h].col]+=-o*p[h].sign;const A=x[0],y=x[1],v=x[2],b=u.getViewportState(),w=Math.abs(A-b.centerX),C=Math.abs(y-b.centerY),M=Math.abs(v-b.centerZ);w<.001&&C<.001&&M<.001||d.push(u.panTo(A,y,v))}d.length>0&&Promise.all(d).then(()=>{this._skipDragInDraw=!0,this.drawScene(),this._skipDragInDraw=!1}).catch(f=>{F.error("Failed to pan Zarr:",f)}),this.canvas.focus();return}const r=this.screenXY2mm(t[2],t[3]);if(isNaN(r[0]))return;const s=this.screenXY2mm(t[0],t[1],r[3]);if(isNaN(s[0])||isNaN(r[0])||isNaN(r[3]))return;const n=U1({startMM:s,endMM:r,pan2DxyzmmAtMouseDown:this.uiData.pan2DxyzmmAtMouseDown});this.scene.pan2Dxyzmm[0]=n.pan2Dxyzmm[0],this.scene.pan2Dxyzmm[1]=n.pan2Dxyzmm[1],this.scene.pan2Dxyzmm[2]=n.pan2Dxyzmm[2],this.canvas.focus()}dragForCenterButton(t){this.dragForPanZoom(t)}dragForSlicer3D(t){const e=this.frac2mm(this.scene.crosshairPos),i=R1({startY:t[1],endY:t[3],pan2DxyzmmAtMouseDown:this.uiData.pan2DxyzmmAtMouseDown,currentPan2Dxyzmm:this.scene.pan2Dxyzmm,crosshairMM:e,yoke3Dto2DZoom:this.opts.yoke3Dto2DZoom});i.volScaleMultiplier!==void 0&&(this.scene.volScaleMultiplier=i.volScaleMultiplier),this.scene.pan2Dxyzmm[0]=i.pan2Dxyzmm[0],this.scene.pan2Dxyzmm[1]=i.pan2Dxyzmm[1],this.scene.pan2Dxyzmm[2]=i.pan2Dxyzmm[2],this.scene.pan2Dxyzmm[3]=i.pan2Dxyzmm[3]}drawMeasurementTool(t,e=!0){const i=(c,h,d,f,u)=>Iu({startXYendXY:[c,h,d,f],distance:u}),r=this.gl;if(r.viewport(0,0,r.canvas.width,r.canvas.height),r.bindVertexArray(this.genericVAO),r.depthFunc(r.ALWAYS),r.enable(r.BLEND),r.blendFunc(r.SRC_ALPHA,r.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),r.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),r.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[r.canvas.width,r.canvas.height]),r.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),r.uniform4fv(this.lineShader.uniforms.startXYendXY,t),r.drawArrays(r.TRIANGLE_STRIP,0,4);const s=this.opts.measureLineColor;s[3]=1,r.uniform4fv(this.lineShader.uniforms.lineColor,s);const n=this.opts.rulerWidth;r.uniform1f(this.lineShader.uniforms.thickness,n*2);let a=[t[0],t[1]-n,t[0],t[1]+n];r.uniform4fv(this.lineShader.uniforms.startXYendXY,a),r.drawArrays(r.TRIANGLE_STRIP,0,4),a=[t[2],t[3]-n,t[2],t[3]+n],r.uniform4fv(this.lineShader.uniforms.startXYendXY,a),r.drawArrays(r.TRIANGLE_STRIP,0,4);let o=this.canvasPos2frac([t[0],t[1]]),l=this.canvasPos2frac([t[2],t[3]]);if(o[0]>=0&&l[0]>=0){const c=this.frac2mm(o);o=k(c[0],c[1],c[2]);const h=this.frac2mm(l);l=k(h[0],h[1],h[2]);const d=se();Qr(d,o,l);const f=Vt(d);let u=2;f>9&&(u=1),f>99&&(u=0);let m=f.toFixed(u);this.opts.showMeasureUnits&&(m=`${m} mm`);let p=t;const[g,x,A,y]=t,{origin:v,terminus:b}=i(g,x,A,y,30);switch(this.opts.measureTextJustify){case"start":p=[...v,...v.map(w=>w+1)];break;case"end":p=p=[...b,...b.map(w=>w+1)];break;default:p=t;break}e&&this.drawTextBetween(p,m,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}r.bindVertexArray(this.unusedVAO)}drawAngleMeasurementTool(){this.uiData.angleState==="drawing_first_line"?this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],!1):this.uiData.angleState==="drawing_second_line"&&(this.drawMeasurementTool(this.uiData.angleFirstLine,!1),this.drawMeasurementTool([this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],!1),this.drawAngleText())}drawAngleText(){const t=this.uiData.angleFirstLine,e=[this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],i=this.calculateAngleBetweenLines(t,e),r=this.uiData.angleFirstLine[2],s=this.uiData.angleFirstLine[3],n=`${i.toFixed(1)}°`;this.drawTextBetween([r,s,r+1,s+1],n,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}drawAngleTextForAngle(t){const e=this.calculateAngleBetweenLines(t.firstLine,t.secondLine),i=t.firstLine[2],r=t.firstLine[3],s=`${e.toFixed(1)}°`;this.drawTextBetween([i,r,i+1,r+1],s,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}calculateAngleBetweenLines(t,e){return F1(t,e)}resetAngleMeasurement(){const t=B1();this.uiData.angleState=t.angleState,this.uiData.angleFirstLine=t.angleFirstLine}getCurrentSliceInfo(){return Z1({dragStart:this.uiData.dragStart,screenSlices:this.screenSlices,crosshairPos:this.scene.crosshairPos,currentSliceType:this.opts.sliceType,canvasPos2frac:t=>this.canvasPos2frac(t)})}getCurrentSlicePosition(t){return gi({sliceType:t,crosshairPos:this.scene.crosshairPos})}shouldDrawOnCurrentSlice(t,e,i){return j1({sliceType:e,slicePosition:i,currentSliceTypeOpt:this.opts.sliceType,screenSlices:this.screenSlices,crosshairPos:this.scene.crosshairPos})}clearMeasurements(){this.document.completedMeasurements=[],this.drawScene()}clearAngles(){this.document.completedAngles=[],this.drawScene()}clearAllMeasurements(){this.document.completedMeasurements=[],this.document.completedAngles=[],this.drawScene()}setDragMode(t){const e=D1(t);if(e===null){console.warn(`Unknown drag mode: ${t}`);return}this.opts.dragMode=e,L1(this.opts.dragMode)||this.resetAngleMeasurement(),this.clearActiveDragMode()}setMouseEventConfig(t){this.opts.mouseEventConfig=t,this.clearActiveDragMode()}setTouchEventConfig(t){this.opts.touchEventConfig=t,this.clearActiveDragMode()}getMouseEventConfig(){return this.opts.mouseEventConfig}getTouchEventConfig(){return this.opts.touchEventConfig}drawRect(t,e=[1,0,0,-1]){if(e[3]<0&&(e=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.gl.disable(this.gl.CULL_FACE),this.opts.selectionBoxIsOutline?(this.drawCircle(t,e,.1),this.rectOutlineShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform1f(this.rectOutlineShader.uniforms.thickness,this.opts.selectionBoxLineThickness),this.gl.uniform4fv(this.rectOutlineShader.uniforms.lineColor,e),this.gl.uniform2fv(this.rectOutlineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectOutlineShader.uniforms.leftTopWidthHeight,t[0],t[1],t[2],t[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)):(this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,e),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,t[0],t[1],t[2],t[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO))}getZarrVolume(){for(const t of this.volumes)if(t.zarrHelper)return t;return null}getZarrVolumes(){return this.volumes.filter(t=>t.zarrHelper)}drawBoundsBox(t,e,i=2){if(!this.rectOutlineShader)throw new Error("rectOutlineShader undefined");const r=this.gl,[s,n,a,o]=t;r.viewport(0,0,r.canvas.width,r.canvas.height),this.rectOutlineShader.use(r),r.enable(r.BLEND),r.uniform1f(this.rectOutlineShader.uniforms.thickness,i),r.uniform4fv(this.rectOutlineShader.uniforms.lineColor,e),r.uniform2fv(this.rectOutlineShader.uniforms.canvasWidthHeight,[r.canvas.width,r.canvas.height]),r.uniform4f(this.rectOutlineShader.uniforms.leftTopWidthHeight,s,n,a,o),r.bindVertexArray(this.genericVAO),r.drawArrays(r.TRIANGLE_STRIP,0,4),r.bindVertexArray(this.unusedVAO)}drawCircle(t,e=this.opts.fontColor,i=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,e),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,t[0],t[1],t[2],t[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,i),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,e),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(t){if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.getCurrentDragMode()===6){this.drawCircle(t,this.opts.selectionBoxColor,.1);return}this.drawRect(t,this.opts.selectionBoxColor)}effectiveCanvasHeight(){return n2({canvasHeight:this.gl.canvas.height,bounds:this.opts.bounds,colorbarHeight:this.colorbarHeight})}effectiveCanvasWidth(){return a2({canvasWidth:this.gl.canvas.width,bounds:this.opts.bounds,legendPanelWidth:this.getLegendPanelWidth()})}getAllLabels(){return Wf({meshes:this.meshes,documentLabels:this.document.labels})}getConnectomeLabels(){return Kf({meshes:this.meshes,documentLabels:this.document.labels})}getBulletMarginWidth(){const t=this.getConnectomeLabels();return c2({labels:t,fontPx:this.fontPx,textHeight:(e,i)=>this.textHeight(e,i)})}getLegendPanelWidth(){const t=this.getConnectomeLabels();return h2({labels:t,showLegend:this.opts.showLegend,fontPx:this.fontPx,canvasWidth:this.gl.canvas.width,textWidth:(e,i)=>this.textWidth(e,i),getBulletMarginWidth:()=>this.getBulletMarginWidth()})}getLegendPanelHeight(t=1){const e=this.getConnectomeLabels();return d2({labels:e,fontPx:this.fontPx,panelScale:t,textHeight:(i,r)=>this.textHeight(i,r)})}reserveColorbarPanel(){const t=f2({fontPx:this.fontPx,boundsRegion:this.getBoundsRegion(),colorbarWidth:this.opts.colorbarWidth});return this.colorbarHeight=t.colorbarHeight,t.leftTopWidthHeight}drawColorbarCore(t=0,e=[0,0,0,0],i=!1,r=0,s=1,n){if(e[2]<=0||e[3]<=0)return;const a=this.fontPx;if(a<=0)return;this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let o=a;const l=3*a;let c=a;if(e[3]<l){if(e[3]<3)return;o=1,c=e[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=e[3]+1;const h=[e[0]+o,e[1],e[2]-2*o,c],d=[h[0]-1,h[1]-1,h[2]+2,h[3]+2];if(this.opts.showColorbarBorder&&this.drawRect(d,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture($.TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const f=t;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,f),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),i){const w=[h[0]+h[2],h[1],-h[2],h[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,w)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,h);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let u=0;if(n&&s<0&&i?(u=s,s=0):n&&r>0&&(u=r,r=0),r===s||a<1)return;const m=Math.abs(s-r);let[p,g]=ys(r,s);g<r&&(g+=p);function x(w){return w.toFixed(6).replace(/\.?0*$/,"")}let A=g;const y=[0,h[1]+h[3]-a*.5,2,a*.75],v=y[1]+y[3],b=1;for(;A<=s;){y[0]=h[0]+(A-r)/m*h[2],this.drawRect(y);const w=x(b*A);this.drawTextBelow([y[0],v],w),A+=p}if(u!==0){const w=[h[0]+(u-r)/m*h[2],h[1]-h[3]*.25,2,h[3]*1.5];this.drawRect(w)}}drawColorbar(){const t=this.colormapLists,e=t.length;if(e<1)return;let i=0;for(let a=0;a<e;a++)t[a].visible&&i++;if(i<1)return;let r=this.reserveColorbarPanel();const s=3*this.fontPx;if(s<0)return;let n=r[2]/i;(r[2]<=0||r[3]<=0)&&(n=this.gl.canvas.width/i,r=[0,this.gl.canvas.height-s,n,s]),r[2]=n;for(let a=0;a<e;a++)t[a].visible&&(this.drawColorbarCore(a,r,t[a].negative,t[a].min,t[a].max,t[a].isColorbarFromZero),r[0]+=n)}textWidth(t,e){return wu({fontMets:this.fontMets,scale:t,str:e})}textHeight(t,e){return yu({fontMets:this.fontMets,scale:t,str:e})}drawChar(t,e,i){if(!this.fontShader)throw new Error("fontShader undefined");const r=this.fontMets.mets[i];if(r){const s=t[0]+e*r.lbwh[0],n=-(e*r.lbwh[1]),a=e*r.lbwh[2],o=e*r.lbwh[3],l=t[1]+(n-o)+e;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,s,l,a,o),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,r.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),e*r.xadv}else return console.warn(`drawChar() : Missing font metric for char : "${i}"`),0}drawLoadingText(t){if(!t)return;if(!this.canvas)throw new Error("canvas undefined");const[e,i,r,s]=this.getBoundsRegion();this.gl.viewport(e,i,r,s),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND);const n=e+r/2,a=i+s/2;this.drawTextBelow([n,a],t,3)}drawText(t,e,i=1,r=null){if(this.fontPx<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const s=this.fontPx*i;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),r===null&&(r=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,r);let n=s/this.fontMets.size*this.fontMets.distanceRange;n=Math.max(n,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,n),this.gl.bindVertexArray(this.genericVAO);for(const a of e){const o=a.codePointAt(0);t[0]+=this.drawChar(t,s,o)}this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(t,e,i=1,r=null){this.fontPx<=0||(t[1]-=.5*this.fontPx,this.drawText(t,e,i,r))}drawTextLeft(t,e,i=1,r=null){if(this.fontPx<=0)return;const s=this.fontPx*i;t[0]-=this.textWidth(s,e),t[1]-=.5*s,this.drawText(t,e,i,r)}drawTextRightBelow(t,e,i=1,r=null){this.fontPx<=0||this.drawText(t,e,i,r)}drawTextBetween(t,e,i=1,r=null){if(this.fontPx<=0)return;const s=Mu(t,e,this.fontPx,i,(a,o)=>this.textWidth(a,o)),n=Du(r,this.opts.crosshairColor);this.drawRect(s.rectLTWH,n),this.drawText([s.textX,s.textY],e,i,r)}drawTextBelow(t,e,i=1,r=null){if(this.fontPx<=0)return;if(!this.canvas)throw new Error("canvas undefined");const s=bu({xy:t,str:e,fontPx:this.fontPx,scale:i,canvasWidth:this.canvas.width},(n,a)=>this.textWidth(n,a));this.drawText([s.x,s.y],e,s.scale,r)}drawTextAbove(t,e,i=1,r=null){if(this.fontPx<=0)return;if(!this.canvas)throw new Error("canvas undefined");const s=Cu({xy:t,str:e,fontPx:this.fontPx,scale:i,canvasWidth:this.canvas.width},(n,a)=>this.textWidth(n,a));this.drawText([s.x,s.y],e,s.scale,r)}updateInterpolation(t,e=!1){_f({gl:this.gl,layer:t,isForceLinear:e,isNearestInterpolation:this.opts.isNearestInterpolation,is2DSliceShader:this.opts.is2DSliceShader})}setAtlasOutline(t){this.opts.atlasOutline=t,this.updateGLVolume(),this.drawScene()}setInterpolation(t){this.opts.isNearestInterpolation=t;const e=this.volumes.length;if(!(e<1)){for(let i=0;i<e;i++)this.updateInterpolation(i);this.drawScene()}}getNearestInterpolation(){return this.opts.isNearestInterpolation}calculateMvpMatrix2D(t,e,i,r=1/0,s=0,n=0,a=0,o=!1){this.gl.viewport(t[0],this.gl.canvas.height-(t[1]+t[3]),t[2],t[3]);let c=e[0],h=i[0],d=[c,e[1]],f=[h-c,i[1]-e[1]];o&&(d=[i[0],e[1]],f=[e[0]-i[0],i[1]-e[1]],c=-i[0],h=-e[0]);const u=2*Math.max(Math.abs(e[2]),Math.abs(i[2])),m=J();let p=.01,g=u*8;if(r!==1/0){let w=o;a===0&&(n===0||n===180)&&(w=!w);let C=u*1.8-s;w||(C=u*1.8+s),g=C-r,p=C+r}hi(m,c,h,e[1],i[1],g,p);const x=J();x[0]=-1;const A=k(0,0,-u*1.8);tt(x,x,A),Ut(x,x,qe(270-a)),Rt(x,x,qe(n-180));const y=J();Se(y,x);const v=J();Te(v,y);const b=J();return Ye(b,m,x),{modelViewProjectionMatrix:b,modelMatrix:x,normalMatrix:v,leftTopMM:d,fovMM:f}}swizzleVec3MM(t,e){return F0(t,e)}screenFieldOfViewVox(t=0){const e=Ve(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(e,t)}screenFieldOfViewMM(t=0,e=!1){if(this.volumes.length<1){let o=k(this.extentsMin[0],this.extentsMin[1],this.extentsMin[2]),l=k(this.extentsMax[0],this.extentsMax[1],this.extentsMax[2]);o=this.swizzleVec3MM(o,t),l=this.swizzleVec3MM(l,t);const c=se();return ne(c,l,o),c}if(!e&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(t);const i=this.volumeObject3D.extentsMin,r=this.volumeObject3D.extentsMax;let s=k(i[0],i[1],i[2]),n=k(r[0],r[1],r[2]);s=this.swizzleVec3MM(s,t),n=this.swizzleVec3MM(n,t);const a=se();return ne(a,n,s),a}screenFieldOfViewExtendedVox(t=0){const e=this.volumes[0].extentsMinOrtho,i=this.volumes[0].extentsMaxOrtho;let r=k(e[0],e[1],e[2]),s=k(i[0],i[1],i[2]);const n=J();r=this.swizzleVec3MM(r,t),s=this.swizzleVec3MM(s,t);const a=se();return ne(a,s,r),{mnMM:r,mxMM:s,rotation:n,fovMM:a}}screenFieldOfViewExtendedMM(t=0){if(this.volumes.length<1){let o=k(this.extentsMin[0],this.extentsMin[1],this.extentsMin[2]),l=k(this.extentsMax[0],this.extentsMax[1],this.extentsMax[2]);const c=J();o=this.swizzleVec3MM(o,t),l=this.swizzleVec3MM(l,t);const h=se();return ne(h,l,o),{mnMM:o,mxMM:l,rotation:c,fovMM:h}}if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const e=this.volumeObject3D.extentsMin,i=this.volumeObject3D.extentsMax;let r=k(e[0],e[1],e[2]),s=k(i[0],i[1],i[2]);const n=J();r=this.swizzleVec3MM(r,t),s=this.swizzleVec3MM(s,t);const a=se();return ne(a,s,r),{mnMM:r,mxMM:s,rotation:n,fovMM:a}}drawSliceOrientationText(t,e,i=[NaN,NaN]){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let r="S";e===0&&(r="A");let s=this.opts.isRadiologicalConvention?"R":"L";e===2&&(s=this.opts.sagittalNoseLeft?"A":"P");let n="I";e===0&&(n="P");let a=this.opts.isRadiologicalConvention?"L":"R";if(e===2&&(a=this.opts.sagittalNoseLeft?"P":"A"),this.opts.isCornerOrientationText){this.drawTextRightBelow([t[0],t[1]],s+r);return}let o=!0,l=!0;const c=this.opts.showAllOrientationMarkers,h=this.opts.showAllOrientationMarkers;if(!isNaN(i[0])){const d=this.fontPx+2;i[1]>d&&(this.drawTextBelow([t[0]+t[2]*.5,t[1]+i[1]-d],r),o=!1);const f=this.textWidth(d,s)+2;i[0]>f&&(this.drawTextRight([t[0]+i[0]-f,t[1]+t[3]*.5],s),l=!1)}o&&this.drawTextBelow([t[0]+t[2]*.5,t[1]],r),l&&this.drawTextRight([t[0],t[1]+t[3]*.5],s),c&&this.drawTextAbove([t[0]+t[2]*.5,t[1]+t[3]],n),h&&this.drawTextLeft([t[0]+t[2],t[1]+t[3]*.5],a)}xyMM2xyzMM(t,e){return l2({axCorSag:t,sliceFrac:e,frac2mm:i=>this.frac2mm(i),swizzleVec3MM:(i,r)=>this.swizzleVec3MM(i,r)})}draw2DMain(t,e,i=NaN){let r=new Float32Array([0,0,0]);this.volumes.length>0&&(r=new Float32Array(this.volumes[0].frac2mm.slice()));let s=this.screenFieldOfViewExtendedMM(e),n=J();!this.opts.isSliceMM&&this.volumes.length>0&&(r=new Float32Array(this.volumes[0].frac2mmOrtho.slice()),n=de(this.volumes[0].mm2ortho),s=this.screenFieldOfViewExtendedVox(e));let a=this.opts.isRadiologicalConvention&&e<2;i===1/0||i===-1/0?(a=i!==1/0,e===1&&(a=!a)):this.opts.sagittalNoseLeft&&e===2&&(a=!a);let o=0,l=0;e===2?l=a?90:-90:e===1?l=a?180:0:(l=a?180:0,o=a?-90:90);const c=this.gl;let h=!1;if(t[2]===0||t[3]===0){h=!0;const A=c.canvas.width/s.fovMM[0],y=c.canvas.height/s.fovMM[1],v=Math.min(A,y),b=A/v,w=y/v;s.fovMM[0]*=b,s.fovMM[1]*=w;let C=(s.mnMM[0]+s.mxMM[0])*.5;s.mnMM[0]=C-s.fovMM[0]*.5,s.mxMM[0]=C+s.fovMM[0]*.5,C=(s.mnMM[1]+s.mxMM[1])*.5,s.mnMM[1]=C-s.fovMM[1]*.5,s.mxMM[1]=C+s.fovMM[1]*.5,t=[0,0,c.canvas.width,c.canvas.height]}if(isNaN(i)){const A=this.scene.pan2Dxyzmm,y=this.swizzleVec3MM(k(A[0],A[1],A[2]),e),v=this.scene.pan2Dxyzmm[3];s.mnMM[0]-=y[0],s.mxMM[0]-=y[0],s.mnMM[1]-=y[1],s.mxMM[1]-=y[1],s.mnMM[0]/=v,s.mxMM[0]/=v,s.mnMM[1]/=v,s.mxMM[1]/=v}let d=2;e===1&&(d=1),e===2&&(d=0);let f=this.scene.crosshairPos[d],u=this.frac2mm(this.scene.crosshairPos);!isNaN(i)&&i!==1/0&&i!==-1/0&&(u=this.frac2mm([.5,.5,.5]),u[d]=i,f=this.mm2frac(u)[d]);const m=u[d],p=c.canvas.height-t[1]-t[3],g=[t[0],p,t[2],t[3]];this.clearBounds(c.DEPTH_BUFFER_BIT,g),c.viewport(g[0],g[1],g[2],g[3]);let x=this.calculateMvpMatrix2D(t,s.mnMM,s.mxMM,1/0,0,l,o,a);if(i===1/0||i===-1/0){const A=t.slice();this.draw3D(t,x.modelViewProjectionMatrix,x.modelMatrix,x.normalMatrix,l,o);const y=this.screenSlices[this.screenSlices.length-1];y.leftTopWidthHeight=A,y.axCorSag=e,y.sliceFrac=1/0,y.AxyzMxy=this.xyMM2xyzMM(e,f),y.leftTopMM=x.leftTopMM,y.fovMM=x.fovMM;return}if(c.enable(c.DEPTH_TEST),c.blendFunc(c.SRC_ALPHA,c.ONE_MINUS_SRC_ALPHA),c.disable(c.BLEND),c.depthFunc(c.ALWAYS),c.disable(c.CULL_FACE),this.volumes.length>0){let A=this.sliceMMShader;if(this.opts.is2DSliceShader&&(A=this.slice2DShader),this.opts.isV1SliceShader&&(A=this.sliceV1Shader),this.customSliceShader&&(A=this.customSliceShader),!A)throw new Error("slice Shader undefined");A.use(this.gl),c.uniform1f(A.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),c.uniform1f(A.uniforms.overlayAlphaShader,this.overlayAlphaShader),c.uniform1i(A.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),c.uniform1i(A.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),c.uniform1f(A.uniforms.drawOpacity,this.drawOpacity),c.uniform1f(A.uniforms.drawRimOpacity,this.drawRimOpacity),c.enable(c.BLEND),c.blendFunc(c.SRC_ALPHA,c.ONE_MINUS_SRC_ALPHA),c.uniform1f(A.uniforms.opacity,this.volumes[0].opacity),c.uniform1i(A.uniforms.axCorSag,e),c.uniform1f(A.uniforms.slice,f),c.uniformMatrix4fv(A.uniforms.frac2mm,!1,r),c.uniformMatrix4fv(A.uniforms.mvpMtx,!1,x.modelViewProjectionMatrix.slice()),c.bindVertexArray(this.genericVAO),c.drawArrays(c.TRIANGLE_STRIP,0,4),c.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:t,axCorSag:e,sliceFrac:f,AxyzMxy:this.xyMM2xyzMM(e,f),leftTopMM:x.leftTopMM,screen2frac:[],fovMM:x.fovMM})}if(c.depthMask(!0),c.depthFunc(c.LEQUAL),isNaN(i)&&this.drawCrosshairs3D(!0,1,x.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(x=this.calculateMvpMatrix2D(t,s.mnMM,s.mxMM,this.opts.meshThicknessOn2D,m,l,o,a));const A=de(x.modelViewProjectionMatrix);Ye(A,A,n),this.drawMesh3D(!0,1,A,x.modelMatrix,x.normalMatrix,!0)}isNaN(i)&&this.drawCrosshairs3D(!1,.15,x.modelViewProjectionMatrix,!0,this.opts.isSliceMM),h&&this.opts.isOrientationTextVisible&&this.drawSliceOrientationText(t,e),this.readyForSync=!0}draw2D(t,e,i=NaN,r=[NaN,NaN]){const[s,n,a,o]=this.getBoundsRegion();let l;t[2]===0&&t[3]===0?this.opts.bounds?l=[s,n,a,o]:l=[0,0,this.gl.canvas.width,this.gl.canvas.height]:l=t.slice();const c=[NaN,NaN];if(r[0]===1/0){const h=this.sliceScale().volScale;let d=this.scaleSlice(h[0],h[1],[0,0],[l[2],l[3]]);e===1&&(d=this.scaleSlice(h[0],h[2],[0,0],[l[2],l[3]])),e===2&&(d=this.scaleSlice(h[1],h[2],[0,0],[l[2],l[3]])),r[0]=d[2],r[1]=d[3]}if(isNaN(r[0])){const h=t[2]===0&&t[3]===0;this.draw2DMain(h?[0,0,0,0]:l,e,i)}else{const h=[NaN,NaN];h[0]=Math.floor(.5*(l[2]-r[0])),h[1]=Math.floor(.5*(l[3]-r[1])),l[0]+=h[0],l[1]+=h[1],l[2]=r[0],l[3]=r[1],this.draw2DMain(l,e,i)}i===1/0||i===-1/0||e===4||l[2]!==0&&l[3]!==0&&this.opts.isOrientationTextVisible&&this.drawSliceOrientationText(l,e,c)}calculateMvpMatrix(t,e=[0,0,0,0],i,r){const s=Au({canvasWidth:this.gl.canvas.width,canvasHeight:this.gl.canvas.height,leftTopWidthHeight:e,azimuth:i,elevation:r,furthestFromPivot:this.furthestFromPivot,pivot3D:this.pivot3D,volScaleMultiplier:this.scene.volScaleMultiplier,position:this.position});return[s.mvpMatrix,s.modelMatrix,s.normalMatrix]}calculateModelMatrix(t,e){if(!this.back)throw new Error("back undefined");return zr({azimuth:t,elevation:e,obliqueRAS:this.back.obliqueRAS})}calculateRayDirection(t,e){return ia({azimuth:t,elevation:e,obliqueRAS:this.back?.obliqueRAS})}sceneExtentsMinMax(t=!0){return Br({volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D},t)}setPivot3D(){const[t,e]=this.sceneExtentsMinMax(),i=xu({sceneMin:t,sceneMax:e});this.pivot3D=i.pivot3D,this.furthestFromPivot=i.furthestFromPivot,this.extentsMin=i.extentsMin,this.extentsMax=i.extentsMax}getMaxVols(){return vu({volumes:this.volumes})}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let t=0;t<this.volumes.length;t++)if(this.volumes[t].nFrame4D<this.volumes[t].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const t=this.graph,[e,i,r,s]=this.getBoundsRegion();let n=0;if(t.autoSizeMultiplanar&&this.opts.sliceType===3)for(let z=0;z<this.screenSlices.length;z++){const W=this.screenSlices[z].axCorSag;if(W===0&&(n=this.screenSlices[z].leftTopWidthHeight[1]),W!==2)continue;const K=this.screenSlices[z].leftTopWidthHeight.slice();K[1]===n?(t.LTWH[0]=K[0]+K[2],t.LTWH[1]=K[1]):(t.LTWH[0]=K[0],t.LTWH[1]=K[1]+K[3]),t.LTWH[2]=K[2],t.LTWH[3]=K[2]}if(t.LTWH[0]=Math.max(e,t.LTWH[0]),t.LTWH[1]=Math.max(i,t.LTWH[1]),t.LTWH[2]=Math.min(r,t.LTWH[2]),t.LTWH[3]=Math.min(s,t.LTWH[3]),t.opacity<=0||t.LTWH[2]<=5||t.LTWH[3]<=5||Math.floor(t.LTWH[0]+t.LTWH[2])>e+r||Math.floor(t.LTWH[1]+t.LTWH[3])>i+s)return;t.backColor=[.15,.15,.15,t.opacity],t.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(t.backColor=[.95,.95,.95,t.opacity],t.lineColor=[0,0,0,1]);const a=.2,o=.3;t.lineColor[3]=a,t.textColor=t.lineColor.slice(),t.textColor[3]=1,t.lineThickness=3,t.gridLineThickness=1,t.lineAlpha=1,t.lines=[];const l=[];if(t.vols.length<1)this.volumes[0]!=null&&l.push(0);else for(let z=0;z<t.vols.length;z++){const W=t.vols[z];this.volumes[W]==null||this.volumes[W].nFrame4D<2||l.push(W)}if(l.length<1)return;const c=this.volumes[l[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[l[0]].frame4D,c<2){F.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let z=0;z<l.length;z++){t.lines[z]=[];const W=this.frac2vox(this.scene.crosshairPos),K=this.volumes[l[z]];let Z=K.nFrame4D;Z=Math.min(Z,c);for(let q=0;q<Z;q++){const te=K.getValue(W[0],W[1],W[2],q);t.lines[z].push(te)}}t.lineRGB=[[.8,0,0],[0,.7,0],[0,0,.9],[.7,.7,0],[.8,0,.8],[0,.7,.7],[.6,.6,.6],[0,0,0]];let h=t.lines[0][0],d=t.lines[0][0];for(let z=0;z<t.lines.length;z++)for(let W=0;W<t.lines[z].length;W++){const K=t.lines[z][W];h=Math.min(K,h),d=Math.max(K,d)}const f=this.volumes[l[0]].cal_min,u=this.volumes[l[0]].cal_max;if(t.isRangeCalMinMax&&f<u&&isFinite(f)&&isFinite(u)&&(h=f,d=u),t.normalizeValues&&d>h){const z=d-h;for(let W=0;W<t.lines.length;W++)for(let K=0;K<t.lines[W].length;K++){const Z=t.lines[W][K];t.lines[W][K]=(Z-h)/z}h=0,d=1}h>=d&&(d=h+1),this.drawRect(t.LTWH,t.backColor);const[m,p,g]=ys(h,d),x=Math.max(0,-1*Math.floor(Math.log(m)/Math.log(10)));h=Math.min(p,h),d=Math.max(g,d);function A(z){return z.toFixed(6).replace(/\.?0*$/,"")}let y=this.fontPx*.7;const v=r/this.uiData.dpr,b=s/this.uiData.dpr,w=v*b,C=800*600;w<C?y=0:y=Math.max(y,this.opts.fontMinPx);const M=y/this.fontPx;let T=0,E=p;if(y>0)for(;E<=d;){const z=E.toFixed(x),W=this.textWidth(y,z);T=Math.max(W,T),E+=m}const I=.05,S=Math.abs(t.LTWH[2]),U=Math.abs(t.LTWH[3]),B=[t.LTWH[0]+I*S+T,t.LTWH[1]+I*U,t.LTWH[2]-T-2*I*S,t.LTWH[3]-y-2.5*I*U];this.graph.LTWH=t.LTWH,this.graph.plotLTWH=B,this.drawRect(B,this.opts.backColor);const V=d-h,R=B[3]/V,P=B[2]/(t.lines[0].length-1),L=B[1]+B[3];E=p+.5*m;const N=t.lineColor.slice();for(N[3]=.5*t.lineColor[3];E<=d;){const z=L-(E-h)*R;this.drawLine([B[0],z,B[0]+B[2],z],t.gridLineThickness,N),E+=m}E=p;const Y=.5*t.gridLineThickness;for(;E<=d;){const z=L-(E-h)*R;this.drawLine([B[0]-Y,z,B[0]+B[2]+t.gridLineThickness,z],t.gridLineThickness,t.lineColor);const W=E.toFixed(x);y>0&&this.drawTextLeft([B[0]-6,z],W,M,t.textColor),E+=m}let _=1;for(;t.lines[0].length/_>20;)_*=5;for(let z=0;z<t.lines[0].length;z+=_){const W=z*P+B[0];let K=t.gridLineThickness;if(z%2===1)K*=.5,this.drawLine([W,B[1],W,B[1]+B[3]],K,N);else{const Z=A(z);y>0&&this.drawTextBelow([W,2+B[1]+B[3]],Z,M,t.textColor),this.drawLine([W,B[1],W,B[1]+B[3]],K,t.lineColor)}}for(let z=0;z<t.lines.length;z++){let W=[1,0,0,t.lineAlpha];z<t.lineRGB.length&&(W=[t.lineRGB[z][0],t.lineRGB[z][1],t.lineRGB[z][2],t.lineAlpha]);for(let K=1;K<t.lines[z].length;K++){const Z=(K-1)*P,q=K*P,te=(t.lines[z][K-1]-h)*R,ue=(t.lines[z][K]-h)*R,le=[B[0]+Z,B[1]+B[3]-te,B[0]+q,B[1]+B[3]-ue];this.drawLine(le,t.lineThickness,W)}}if(t.selectedColumn>=0&&t.selectedColumn<t.lines[0].length){const z=t.selectedColumn*P+B[0];this.drawLine([z,B[1],z,B[1]+B[3]],t.lineThickness,[t.lineRGB[0][0],t.lineRGB[0][1],t.lineRGB[0][2],o])}y>0&&t.LTWH[1]+t.LTWH[3]>B[1]+B[3]+y*2.4&&this.drawTextBelow([B[0]+.5*B[2],B[1]+B[3]+y*1.2],"Volume",M,t.textColor),this.detectPartialllyLoaded4D()&&this.drawTextBelow([B[0]+B[2],B[1]+B[3]+y*.5],"...",M,t.textColor)}depthPicker(t,e){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const i=this.gl,r=this.mousePos[0]*t[2]/t[2],s=i.canvas.height-this.mousePos[1]*t[3]/t[3]-1,n=new Uint8Array(4);if(i.readPixels(r,s,1,1,i.RGBA,i.UNSIGNED_BYTE,n),this.selectedObjectId=n[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(n.slice(0,3)).map(d=>d/255);return}const a=M0(n);if(a>1)return;const o=(this.mousePos[0]-t[0])/t[2],l=(i.canvas.height-this.mousePos[1]-t[1])/t[3],c=T0(o,l,a,e),h=this.mm2frac(c,0,!0);h[0]<0||h[0]>1||h[1]<0||h[1]>1||h[2]<0||h[2]>1||(this.scene.crosshairPos=this.mm2frac(c,0,!0))}drawImage3D(t,e,i){iu({gl:this.gl,mvpMatrix:t,azimuth:e,elevation:i,volumesLength:this.volumes.length,volumeObject3D:this.volumeObject3D,unusedVAO:this.unusedVAO,renderShader:this.renderShader,pickingImageShader:this.pickingImageShader,mouseDepthPicker:this.uiData.mouseDepthPicker,backgroundMasksOverlays:this.backgroundMasksOverlays,gradientTextureAmount:this.gradientTextureAmount,gradientTexture:this.gradientTexture,drawBitmap:this.drawBitmap,renderDrawAmbientOcclusion:this.renderDrawAmbientOcclusion,drawOpacity:this.drawOpacity,smoothDrawing:this.opts.smoothDrawing,drawSmoothedTexture:this.drawSmoothedTexture,paqdUniforms:this.opts.paqdUniforms,matRAS:this.back.matRAS,crosshairPos:this.scene.crosshairPos,clipPlaneDepthAziElevs:this.scene.clipPlaneDepthAziElevs,isClipPlanesCutaway:this.opts.isClipPlanesCutaway,isClipAllVolumes:this.opts.isClipAllVolumes,obliqueRAS:this.back?.obliqueRAS})}drawOrientationCube(t,e=0,i=0){if(!this.opts.isOrientCube)return;const r=.05*Math.min(t[2],t[3]);if(r<5)return;const s=this.gl;s.enable(s.CULL_FACE),s.cullFace(s.BACK),s.disable(s.DEPTH_TEST),this.orientCubeShader.use(this.gl),s.bindVertexArray(this.orientCubeShaderVAO);const n=J(),a=J();hi(a,0,s.canvas.width,0,s.canvas.height,-10*r,10*r);let o=0;t[1]===0&&(o=s.canvas.height-this.effectiveCanvasHeight()),tt(n,n,[1.8*r+t[0],o+1.8*r+t[1],0]),fr(n,n,[r,r,r]),Ut(n,n,qe(270-i)),Rt(n,n,qe(-e));const l=J();Ye(l,a,n),s.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,l),s.drawArrays(s.TRIANGLE_STRIP,0,168),s.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(t=NaN){const[e,i,r]=this.sceneExtentsMinMax(!0),s=Math.max(Math.max(r[0],r[1]),r[2]);function n(d){return Math.max(0,-Math.ceil(Math.log10(Math.abs(d))))}let a=n(s*.001);const o=this.frac2mm(this.scene.crosshairPos,0,!0);function l(d,f=0){return parseFloat(Number(d).toFixed(f))}let c=l(o[0],a)+"×"+l(o[1],a)+"×"+l(o[2],a);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(c+="×"+l(this.volumes[0].frame4D)),this.volumes.length>0){let d=" = ";for(let m=0;m<this.volumes.length;m++){const p=this.volumes[m].mm2vox(o);let g=this.volumes[m].getValue(p[0],p[1],p[2],this.volumes[m].frame4D);if(a=3,this.volumes[m].colormapLabel!==null){const x=Math.round(g);if(this.volumes[m].hdr.intent_code===1002&&this.volumes[m].hdr.datatypeCode===2304){const A=this.volumes[m].getValues(p[0],p[1],p[2],this.volumes[m].frame4D);if(A[2]>2){const y=Math.round(100*A[2]/255);if(d+=this.volumes[m].colormapLabel.labels[A[0]]+` (${y}%)`,A[3]>2){const v=Math.round(100*A[3]/255);d+=" "+this.volumes[m].colormapLabel.labels[A[1]]+` (${v}%)`}}}else x>=0&&this.volumes[m].colormapLabel.labels&&x<this.volumes[m].colormapLabel.labels.length?d+=this.volumes[m].colormapLabel.labels[x]:d+="undefined("+l(g,a)+")"}else d+=l(g,a);this.volumes[m].imaginary&&(g=this.volumes[m].getValue(p[0],p[1],p[2],this.volumes[m].frame4D,!0),g>=0&&(d+="+"),d+=l(g,a)),d+="   "}c+=d;const f=this.back.dimsRAS,u=f[1]*f[2]*f[3];if(this.drawBitmap&&this.drawBitmap.length===u){const m=this.frac2vox(this.scene.crosshairPos),p=m[0]+m[1]*f[1]+m[2]*f[1]*f[2];c+=" "+this.drawLut.labels[this.drawBitmap[p]]}}const h={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:t,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(d=>{const f=this.frac2mm(this.scene.crosshairPos,0,!0),u=d.mm2vox(f),m=d.getValue(u[0],u[1],u[2],d.frame4D);return{name:d.name,value:m,id:d.id,mm:f,vox:u}}),string:c};this._emitEvent("locationChange",h),this.onLocationChange(h)}addLabel(t,e,i,r,s){const n={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},a=e?{...n,...e}:{...n},o=new Er(t,{...a},i,r,s);return this.document.labels.push(o),o}calculateScreenPoint(t,e,i){const r=Xe();return ve(r,[...t,1],e),r[3]!==0&&(r[0]=(r[0]/r[3]+1)*.5*i[2],r[1]=(1-r[1]/r[3])*.5*i[3],r[2]/=r[3],r[0]+=i[0],r[1]+=i[1]),r}getLabelAtPoint(t){const e=this.legendFontScaling,i=this.fontPx*e,r=this.fontPx*e;for(const c of this.document.labels){if(c.anchor==null||c.anchor===0)continue;const h=this.fontPx*c.style.textScale*e,d=this.textHeight(h,c.text),f=this.textWidth(h,c.text);if(!(c.anchor&1&&t[0]>f)&&!(c.anchor&2&&(t[0]<(this.gl.canvas.width-f)/2||t[0]>(this.gl.canvas.width+f)/2))&&!(c.anchor&4&&t[0]<this.gl.canvas.width-f)&&!(c.anchor&8&&(t[1]<r/2||t[1]>d+r/2))&&!(c.anchor&16&&(t[1]<(this.gl.canvas.height-d-r)/2||t[1]>(this.gl.canvas.height+d-r/2)/2))&&!(c.anchor&32&&(t[1]<this.gl.canvas.height-d-r||t[1]>this.gl.canvas.height-r/2)))return c}F.debug("screenPoint",t);const s=this.getLegendPanelHeight(e),n=this.getLegendPanelWidth(),a=this.gl.canvas.width-n;let o=(this.canvas.height-s)/2;if(F.debug("panelrect",a,o,a+n,o+s),t[0]<a||t[1]<o||t[0]>a+n||t[1]>o+s)return null;const l=this.getConnectomeLabels();for(const c of l){const h=this.fontPx*c.style.textScale*e,d=this.textHeight(h,c.text);if(t[1]>=o&&t[1]<=o+d+i/2)return F.debug(`label clicked ${c.text}`),c;o+=d,o+=i/2}return null}drawLabelLine(t,e,i,r,s=!1){const n=Array.isArray(t.points)&&Array.isArray(t.points[0])?t.points:[t.points];for(const a of n){const o=this.calculateScreenPoint(a,i,r);s?this.drawDottedLine([...e,o[0],o[1]],t.style.lineWidth,t.style.lineColor):this.draw3DLine(e,[o[0],o[1],o[2]],t.style.lineWidth,t.style.lineColor)}}draw3DLabel(t,e,i,r,s,n,a,o=1){const l=t.text,c=e[0],h=e[1],d=this.fontPx*o,f=this.textHeight(t.style.textScale,l)*d;if(t.style.lineWidth>0&&Array.isArray(t.points)&&this.drawLabelLine(t,[c,h+f],i,r,a),t.style.bulletScale){const p=t.style.bulletScale*f,g=f-p,x=h+g/2+p/2,A=c+(s-p)/2;this.drawCircle([A,x,p,p],t.style.bulletColor)}let u=c;if(n)if(t.style.textAlignment!=="left"){const p=this.textWidth(t.style.textScale,t.text)*d;if(t.style.textAlignment==="right")u=c+n-d*1.5-p;else{const g=n-(s||d);u+=(g-p)/2}}else u+=s;const m=t.style.textScale;this.drawText([u,h],l,m,t.style.textColor)}draw3DLabels(t,e,i=!1){const r=this.getConnectomeLabels();if(!this.opts.showLegend||r.length===0)return;let s=this.getLegendPanelHeight(1);if(!this.canvas||s<1)return;const n=this.gl;if(n.disable(n.CULL_FACE),n.viewport(0,0,this.canvas.width,this.canvas.height),this.legendFontScaling=1,s>this.canvas.height){const u=10*this.uiData.dpr;this.legendFontScaling=Math.max(this.canvas.height-u,1)/s,F.debug(`Legend too large for screen, font reduction factor x${this.legendFontScaling}`),s=this.getLegendPanelHeight(this.legendFontScaling)}const a=this.fontPx*this.legendFontScaling,o=this.getBulletMarginWidth(),l=this.getLegendPanelWidth(),c=n.canvas.width-l;let h=(this.canvas.height-s)/2;this.drawRect([n.canvas.width-l,h,l-a,s],this.opts.legendBackgroundColor);const d=n.getParameter(n.BLEND),f=n.getParameter(n.DEPTH_FUNC);i||(n.disable(n.BLEND),n.depthFunc(n.LEQUAL));for(const u of r){this.draw3DLabel(u,[c,h],t,e,o,l,i,this.legendFontScaling);const m=this.fontPx*u.style.textScale,p=this.textHeight(m,u.text)*this.legendFontScaling;h+=p,h+=a/2}i||(n.depthFunc(f),d&&n.enable(n.BLEND))}drawAnchoredLabels(){const t=this.fontPx,e=this.document.labels.filter(i=>i.anchor!=null&&i.anchor!==0);for(const i of e){const r=i.text,s=this.textHeight(i.style.textScale,r)*t,n=this.textWidth(i.style.textScale,r)*t;let a,o;const c=this.fontPx*1,h=c;let d=c/4,f=0,u=0;i.anchor&1&&(a=0),i.anchor&4&&(a=this.canvas.width-n,f-=c/4),i.anchor&2&&(a=(this.canvas.width-n)/2,f-=c/4,d+=c/4),i.anchor&8&&(o=0),i.anchor&16&&(o=(this.canvas.height-s-c)/2,u-=c/4),i.anchor&32&&(o=this.canvas.height-s-c,u-=c/4),this.drawRect([a+f,o+u,n+d,s+h],i.style.backgroundColor),this.draw3DLabel(i,[a,o])}}draw3D(t=[0,0,0,0],e=null,i=null,r=null,s=null,n=0){const a=this.gl,[o,l,c,h]=this.getBoundsRegion();let d=[...t];(d[2]===0||d[3]===0)&&(d=this.opts.bounds?[o,l,c,h]:[0,0,a.canvas.width,a.canvas.height]);const f=s!==null;this.setPivot3D(),f||(s=this.scene.renderAzimuth,n=this.scene.renderElevation),e===null&&([e,i,r]=this.calculateMvpMatrix(null,d,s,n));const u=[...d];this.screenSlices.push({leftTopWidthHeight:d.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[D0(i),0]});const m=[d[0],a.canvas.height-d[3]-d[1],d[2],d[3]];if(d[1]=a.canvas.height-d[3]-d[1],a.clear(a.DEPTH_BUFFER_BIT),a.enable(a.DEPTH_TEST),a.depthFunc(a.ALWAYS),a.depthMask(!0),this.draw3DLabels(e,u,!1),this.gl.viewport(m[0],m[1],m[2],m[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(e,s,n)),this.updateInterpolation(0),this.updateInterpolation(1),f||this.drawCrosshairs3D(!0,1,e),this.drawMesh3D(!0,1,e,i,r),this.uiData.mouseDepthPicker){this.depthPicker(d,e),this.createOnLocationChange(),this.draw3D(u,e,i,r,s,n);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,e,i,r),this.gl.disable(this.gl.CULL_FACE),this.draw3DLabels(e,u,!1),a.viewport(d[0],d[1],d[2],d[3]),f||this.drawCrosshairs3D(!1,.15,e),a.viewport(o,l,c,h),this.drawOrientationCube(d,s,n);const p="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(e,u,!0),p}drawMesh3D(t=!0,e=1,i,r,s,n=!1){this.meshes.length<1||(i||([i,r,s]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),gu({gl:this.gl,meshes:this.meshes,isDepthTest:t,alpha:e,mvpMatrix:i,modelMatrix:r,normalMatrix:s,is2D:n,meshShaders:this.meshShaders,pickingMeshShader:this.pickingMeshShader,fiberShader:this.fiberShader,mouseDepthPicker:this.uiData.mouseDepthPicker,matCapTexture:this.matCapTexture,unusedVAO:this.unusedVAO,meshXRay:this.opts.meshXRay,meshThicknessOn2D:this.opts.meshThicknessOn2D,frac2mm:a=>this.frac2mm(a,0,this.opts.isSliceMM),crosshairPos:this.scene.crosshairPos}),this.readyForSync=!0)}drawCrosshairs3D(t=!0,e=1,i=null,r=!1,s=!0){if(!this.opts.show3Dcrosshair&&!r||this.opts.crosshairWidth<=0&&r)return;const n=this.gl,a=this.frac2mm(this.scene.crosshairPos,0,s);let o=1;const[l,c,h]=this.sceneExtentsMinMax(s);if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");o=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(h[0]<50||h[0]>1e3)&&(o=h[0]*.02);if(o*=this.opts.crosshairWidth,this.opts?.crosshairWidthUnit==="percent"&&(o=h[0]*this.opts.crosshairWidth*.5*.01),this.opts?.crosshairWidthUnit==="mm"&&(o=this.opts.crosshairWidth*.5),(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==a[0]||this.crosshairs3D.mm[1]!==a[1]||this.crosshairs3D.mm[2]!==a[2])&&(this.crosshairs3D!==null&&(n.deleteBuffer(this.crosshairs3D.indexBuffer),n.deleteBuffer(this.crosshairs3D.vertexBuffer)),this.crosshairs3D=st.generateCrosshairs(this.gl,1,a,l,c,o,20,this.opts.crosshairGap),this.crosshairs3D.mm=a),!this.surfaceShader)throw new Error("surfaceShader undefined");const d=this.surfaceShader;d.use(this.gl),i==null&&([i]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),n.uniformMatrix4fv(d.uniforms.mvpMtx,!1,i),n.disable(n.CULL_FACE),n.bindBuffer(n.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),n.enable(n.DEPTH_TEST);const f=[...this.opts.crosshairColor];t?(n.disable(n.BLEND),n.depthFunc(n.LEQUAL)):(n.enable(n.BLEND),n.blendFunc(n.SRC_ALPHA,n.ONE_MINUS_SRC_ALPHA),n.depthFunc(n.ALWAYS)),f[3]=e,n.uniform4fv(d.uniforms.surfaceColor,f),n.bindVertexArray(this.crosshairs3D.vao),n.drawElements(n.TRIANGLES,this.crosshairs3D.indexCount,n.UNSIGNED_INT,0),n.bindVertexArray(this.unusedVAO)}mm2frac(t,e=0,i=!1){return zn(t,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,volIdx:e,isSliceMM:i||this.opts.isSliceMM})}vox2frac(t,e=0){return S0(t,this.volumes,e)}frac2vox(t,e=0){return E0(t,this.volumes,e)}moveCrosshairInVox(t,e,i){const r=this.frac2vox(this.scene.crosshairPos),s=$1({x:t,y:e,z:i,currentVox:r,dimsRAS:this.volumes[0].dimsRAS});this.scene.crosshairPos=this.vox2frac(s.newVox),this.createOnLocationChange(),this.opts.is2DSliceShader&&s.zChanged&&(this.updateGLVolume(),this.refreshDrawing(!1)),this.drawScene()}frac2mm(t,e=0,i=!1){return wi(t,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,volIdx:e,isSliceMM:i||this.opts.isSliceMM})}screenXY2TextureFrac(t,e,i,r=!0){return Ur(t,e,this.screenSlices,i,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,isSliceMM:this.opts.isSliceMM,restrict0to1:r})}canvasPos2frac(t){return U0(t,this.screenSlices,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,isSliceMM:this.opts.isSliceMM})}frac2canvasPosWithTile(t,e){return V0(t,this.screenSlices,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,isSliceMM:this.opts.isSliceMM,preferredSliceType:e})}frac2canvasPos(t){return R0(t,this.screenSlices,{volumes:this.volumes,meshes:this.meshes,volumeObject3D:this.volumeObject3D,isSliceMM:this.opts.isSliceMM,sliceType:this.opts.sliceType})}scaleSlice(t,e,i=[0,0],r=[0,0]){const s=r[0]===0?this.effectiveCanvasWidth()-i[0]:r[0]-i[0],n=r[1]===0?this.effectiveCanvasHeight()-i[1]:r[1]-i[1];let a=s/t;e*a>n&&(a=n/e);const o=t*a,l=e*a;return[(s-o)*.5,(n-l)*.5,o,l,a]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl);const[t,e,i,r]=this.getBoundsRegion();this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,i,r);const s=Bu(i,r,this.bmpTextureWH),n=t+s.left,a=e+s.top;this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,n,a,s.width,s.height),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(t,e=1,i=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),i[3]<0&&(i=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,i),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,e),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,t),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(t,e,i=1,r=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),r[3]<0&&(r=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,r),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,i),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,t),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,e),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(t,e=1,i=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const r=i[3]<0?[...this.opts.crosshairColor]:[...i];r[3]=.3,this.gl.uniform4fv(this.lineShader.uniforms.lineColor,r),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,e);const s=Fu(t,this.fontPx,1);for(const n of s)this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,[n.startX,n.startY,n.endX,n.endY]),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(t,e=[1,0,0,.5],i=2){this.drawLine(t,i,e)}drawCrossLinesMM(t,e,i,r,s){if(t<0||this.screenSlices.length<=t)return;const n=this.screenSlices[t];let a=n.sliceFrac;a===1/0&&F.debug("Rendering approximate cross lines in world view mode"),a===1/0&&(a=.5);const{linesH:l,linesV:c}=Ts(e,i,r,s),h=Math.max(1,this.opts.crosshairWidth),d=f=>{const u=La(0,0);return u[0]=n.leftTopWidthHeight[0]+(f[0]-n.leftTopMM[0])/n.fovMM[0]*n.leftTopWidthHeight[2],u[1]=n.leftTopWidthHeight[1]+n.leftTopWidthHeight[3]-(f[1]-n.leftTopMM[1])/n.fovMM[1]*n.leftTopWidthHeight[3],u};if(l.length>0&&e===0){const f=a,u=1;for(let m=0;m<l.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=l[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([0,g,f]);x=he(x,[0,1,2]);let A=this.frac2mm([1,g,f]);A=he(A,[0,1,2]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}if(l.length>0&&e===1){const f=a,u=2;for(let m=0;m<l.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=l[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([0,f,g]);x=he(x,[0,2,1]);let A=this.frac2mm([1,f,g]);A=he(A,[0,2,1]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}if(l.length>0&&e===2){const f=a,u=2;for(let m=0;m<l.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=l[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([f,0,g]);x=he(x,[1,2,0]);let A=this.frac2mm([f,1,g]);A=he(A,[1,2,0]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}if(c.length>0&&e===0){const f=a,u=0;for(let m=0;m<c.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=c[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([g,0,f]);x=he(x,[0,1,2]);let A=this.frac2mm([g,1,f]);A=he(A,[0,1,2]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}if(c.length>0&&e===1){const f=a,u=0;for(let m=0;m<c.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=c[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([g,f,0]);x=he(x,[0,2,1]);let A=this.frac2mm([g,f,1]);A=he(A,[0,2,1]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}if(c.length>0&&e===2){const f=a,u=1;for(let m=0;m<c.length;m++){const p=this.frac2mm([.5,.5,.5]);p[u]=c[m];let g=this.mm2frac(p);g=g[u];let x=this.frac2mm([f,g,0]);x=he(x,[1,2,0]);let A=this.frac2mm([f,g,1]);A=he(A,[1,2,0]),x=d(x),A=d(A),this.drawLine([x[0],x[1],A[0],A[1]],h)}}}drawCrossLines(t,e,i,r,s){if(t<0||this.screenSlices.length<=t)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(t,e,i,r,s);if(this.screenSlices[t].sliceFrac===1/0)return this.drawCrossLinesMM(t,e,i,r,s);const n=this.screenSlices[t],{linesH:a,linesV:o}=Ts(e,i,r,s);if(a.length>0){const l=n.leftTopWidthHeight.slice();let c=2;e===0&&(c=1);const h=this.frac2mm([.5,.5,.5]);for(let d=0;d<a.length;d++){h[c]=a[d];const f=this.mm2frac(h);this.drawRect([l[0],l[1]+l[3]-f[c]*l[3],l[2],1])}}if(o.length>0){const l=n.leftTopWidthHeight.slice(),c=n.fovMM[0]<0;let h=0;e===2&&(h=1);const d=this.frac2mm([.5,.5,.5]);for(let f=0;f<o.length;f++){d[h]=o[f];const u=this.mm2frac(d);c?this.drawRect([l[0]+(l[2]-u[h]*l[2]),l[1],1,l[3]]):this.drawRect([l[0]+u[h]*l[2],l[1],1,l[3]])}}}drawMosaic(t){this.screenSlices=[];const[e,i,r,s]=this.getBoundsRegion(),n=this.screenFieldOfViewMM(0,!0),a=this.screenFieldOfViewMM(0);t=t.replaceAll(";"," ;").trim();const o=[],l=[],c=[],h=t.split(/\s+/);let d=1;const f=this.fontPx;let u=0,m=0,p=0;this.volumes[0]?.dims||(p=Math.ceil(this.opts.tileMargin*.3));for(let g=0;g<2;g++){let x=!1,A=!1,y=0,v=0,b=0,w=0,C=!1,M=0,T=0,E=0,I=0;for(let B=0;B<h.length;B++){const V=h[B];if(V.includes("X")){A=!0;continue}if(V.includes("L")){C=!V.includes("-");continue}if(V.includes("H")){B++,T=Math.abs(Math.max(0,Math.min(1,parseFloat(h[B]))));continue}if(V.includes("V")){B++;continue}if(V.includes("A")){M=0;continue}if(V.includes("C")){M=1;continue}if(V.includes("S")){M=2;continue}if(V.includes("R")){x=!0;continue}if(V.includes(";")){b+=y,w=Math.max(w,v+E),y=0,v=0,E=0;continue}I=E,T>0&&!x&&(I=Math.round(I*(1-T))),v+=I,I=0;const R=parseFloat(V);if(isNaN(R))continue;let P=0,L=a;if(x&&(L=n),M===2?I=L[1]:I=L[0],M===0?P=L[1]:P=L[2],g===0)x||(M===0&&o.push(R),M===1&&l.push(R),M===2&&c.push(R));else{const N=[e+u+d*v,i+m+d*b,d*I,d*P];if(this.fontPx=C?f:0,x){let Y=R<0?-1/0:1/0;Object.is(R,-0)&&(Y=-1/0),this.draw2D(N,M,Y)}else this.draw2D(N,M,R);A&&this.drawCrossLines(this.screenSlices.length-1,M,o,l,c),x=!1,A=!1}E=I,v+=p,y=Math.max(y,P)}if(b+=y,w=Math.max(w,v+E),w<=0||b<=0)break;const S=(r-2*this.opts.tileMargin-p)/w,U=(s-2*this.opts.tileMargin)/b;d=Math.min(S,U),this.opts.centerMosaic?(u=Math.floor(.5*(r-w*d)),m=Math.floor(.5*(s-b*d))):(u=this.opts.tileMargin,m=this.opts.tileMargin)}this.fontPx=f}calculateWidthHeight(t,e,i,r){return Jf(t,e,i,r)}getBoundsRegionCSS(){const t=this.gl.canvas.getBoundingClientRect();return s2({bounds:this.opts.bounds,rectWidth:t.width,rectHeight:t.height})}eventInBounds(t){const e=this.gl.canvas.getBoundingClientRect();let i,r;if(t instanceof MouseEvent)i=t.clientX,r=t.clientY;else if(t instanceof TouchEvent){const a=t.touches[0]??t.changedTouches[0];if(!a)return!1;i=a.clientX,r=a.clientY}else i=t.clientX,r=t.clientY;const s=i-e.left,n=r-e.top;return u2({x:s,y:n,boundsRegion:this.getBoundsRegionCSS()})}cursorInBounds(){return m2({mouseX:this.mousePos[0],mouseY:this.mousePos[1],boundsRegion:this.getBoundsRegion()})}getBoundsRegion(){const t=this.gl,e=this.uiData?.dpr||window.devicePixelRatio||1,i=t.canvas;return r2({bounds:this.opts.bounds,canvasWidth:t.canvas.width,canvasHeight:t.canvas.height,cssWidth:i.clientWidth,cssHeight:i.clientHeight,dpr:e})}inBounds(t,e){return Q1({x:t,y:e,dpr:this.uiData.dpr,canvasHeight:this.gl.canvas.height,boundsRegion:this.getBoundsRegion()})}bindTextures(){this.gl.activeTexture($.TEXTURE0_BACK_VOL),this.opts.is2DSliceShader?this.gl.bindTexture(this.gl.TEXTURE_2D,this.volumeTexture):this.gl.bindTexture(this.gl.TEXTURE_3D,this.volumeTexture),this.gl.activeTexture($.TEXTURE2_OVERLAY_VOL),this.gl.bindTexture(this.gl.TEXTURE_3D,this.overlayTexture),this.gl.activeTexture($.TEXTURE8_PAQD),this.gl.bindTexture(this.gl.TEXTURE_3D,this.paqdTexture),this.gl.activeTexture($.TEXTURE3_FONT),this.gl.bindTexture(this.gl.TEXTURE_2D,this.fontTexture),this.gl.activeTexture($.TEXTURE1_COLORMAPS),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.activeTexture($.TEXTURE5_MATCAP),this.gl.bindTexture(this.gl.TEXTURE_2D,this.matCapTexture),this.gl.activeTexture($.TEXTURE6_GRADIENT),this.gl.bindTexture(this.gl.TEXTURE_3D,this.gradientTexture)}clearBounds(t=this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT,e){const i=this.gl,[r,s,n,a]=e??this.getBoundsRegion(),o=i.canvas.height-s-a;t&i.DEPTH_BUFFER_BIT&&i.clearDepth(1),i.enable(i.SCISSOR_TEST),i.scissor(r,o,n,a),t&i.COLOR_BUFFER_BIT&&i.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),i.clear(t),i.disable(i.SCISSOR_TEST)}drawBoundsBorder(){if(!this.opts.showBoundsBorder)return;const[t,e,i,r]=this.getBoundsRegion();this.drawBoundsBox([t,e,i,r],this.opts.boundsBorderColor,this.opts.selectionBoxLineThickness)}drawSceneCore(){if(!this.initialized)return;this.colorbarHeight=0;const[t,e,i,r]=this.getBoundsRegion();if(this.gl.viewport(t,e,i,r),this.clearBounds(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bindTextures(),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let s="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){if(this.sliceMosaicString.length>0){this.opts.isColorbar&&this.reserveColorbarPanel(),this.drawMosaic(this.sliceMosaicString),this.opts.isColorbar&&this.drawColorbar();return}this.screenSlices=[],this.draw3D([t,e,i,r]),this.opts.isColorbar&&this.drawColorbar(),this.drawAnchoredLabels();return}this.drawLoadingText(this.opts.loadingText);return}const n=this.scene.clipPlaneDepthAziElevs?.[this.uiData.activeClipPlaneIndex]?.[0]??2;if(T2({isDragging:this.uiData.isDragging,activeClipPlaneDepth:n,dragStartTileIndex:this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])})){const d=this.uiData.dragStart[0]-this.uiData.dragEnd[0],f=this.uiData.dragStart[1]-this.uiData.dragEnd[1],u=b2({startDepthAziElev:this.uiData.dragClipPlaneStartDepthAziElev,dragDeltaX:d,dragDeltaY:f});if(u.changed){const m=this.uiData.activeClipPlaneIndex;this.scene.clipPlaneDepthAziElevs[m]=u.depthAziElev;const p=ha({depth:u.depthAziElev[0],azimuth:u.depthAziElev[1],elevation:u.depthAziElev[2]});this.scene.clipPlanes[m]=p,this._emitEvent("clipPlaneChange",{clipPlane:p}),this.onClipPlaneChange(p)}}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar(),this.drawAnchoredLabels();return}this.opts.isColorbar&&this.reserveColorbarPanel();const o=this.getMaxVols(),l=this.opts.sliceType===3&&o>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else{const d=[0,0];let f=!1;if(this.screenSlices=[],this.customLayout&&this.customLayout.length>0){this.screenSlices=[];const{volScale:u}=this.sliceScale();for(const m of this.customLayout){const{sliceType:p,position:g,sliceMM:x}=m,A=[t+g[0]*i,e+g[1]*r,g[2]*i,g[3]*r];if(A[0]+A[2]>t+i&&(F.warn("adjusting slice width because it would have been clipped"),A[2]=t+i-A[0]),A[1]+A[3]>e+r&&(F.warn("adjusting slice height because it would have been clipped"),A[3]=e+r-A[1]),p===4)this.draw3D(A);else{const y=this.calculateWidthHeight(p,u,A[2],A[3]);this.draw2D(A,p,x??NaN,y)}}}else if(this.opts.sliceType===0||this.opts.sliceType===1||this.opts.sliceType===2)this.draw2D([0,0,0,0],this.opts.sliceType,NaN);else{let u=function(q,te){return[(q-1)*A+q*y,(te-1)*A+te*y]},m=!1;this.opts.multiplanarForceRender?(m=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(m=!0);const p=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:g}=this.sliceScale(),x=g.slice();this.opts.multiplanarEqualSize&&(g[0]=1,g[1]=1,g[2]=1),typeof this.opts.multiplanarPadPixels!="number"&&F.debug("multiplanarPadPixels must be numeric");const A=parseFloat(`${this.opts.multiplanarPadPixels}`)*this.uiData.dpr;let y=this.opts.tileMargin*this.uiData.dpr;y<0&&(y=2*(2+Math.ceil(this.fontPx)));const[v,b,w,C]=this.getBoundsRegion();let M=[this.effectiveCanvasWidth(),this.effectiveCanvasHeight()];this.opts.heroImageFraction>0&&this.opts.heroImageFraction<1&&(m=!1,f=!0,M[0]>M[1]&&this.opts.multiplanarLayout!==3?d[0]=M[0]*this.opts.heroImageFraction:d[1]=M[1]*this.opts.heroImageFraction,M=[M[0]-d[0],M[1]-d[1]]);const T=this.scaleSlice(g[0]+g[1],g[1]+g[2],u(2,2),M),E=Math.max(Math.max(g[1],g[2]),g[0]),I=this.scaleSlice(g[0]+g[0]+g[1],Math.max(g[1],g[2]),u(3,1),M),S=this.scaleSlice(g[0]+g[0]+g[1]+E,Math.max(g[1],g[2]),u(4,1),M),U=this.scaleSlice(E,g[1]+g[2]+g[2],u(1,3),M),B=this.scaleSlice(E,g[1]+g[2]+g[2]+E,u(1,4),M);let V=!p&&(o<2||!l),R=!1,P=!1,L=!1;this.opts.multiplanarLayout===1?R=!0:this.opts.multiplanarLayout===2?P=!0:this.opts.multiplanarLayout===3?L=!0:U[4]>I[4]&&U[4]>T[4]?R=!0:I[4]>T[4]?L=!0:P=!0;let N=T;if(R?(N=U,!f&&(m||this.opts.multiplanarShowRender===2&&B[4]>=U[4])?N=B:V=!1):L&&(N=I,!f&&(m||this.opts.multiplanarShowRender===2&&S[4]>=I[4])?N=S:V=!1),f){const q=d[0]===0?w:d[0],te=d[1]===0?C:d[1];if(this.opts?.heroSliceType===0||this.opts?.heroSliceType===1||this.opts?.heroSliceType===2)this.draw2D([v,b,q,te],this.opts.heroSliceType,NaN,[1/0,1/0]);else{const ue=N.slice();q===w&&(ue[0]=0),this.draw3D([v+ue[0],b,q,te])}N[0]+=d[0],N[1]+=d[1],V=!1}const Y=g[0]*N[4]+y,_=g[1]*N[4]+y,z=g[2]*N[4]+y,W=x[0]*N[4],K=x[1]*N[4],Z=x[2]*N[4];if(R){if(this.draw2D([v+N[0],b+N[1],Y,_],0,NaN,[W,K]),this.draw2D([v+N[0],b+N[1]+_+A,Y,z],1,NaN,[W,Z]),this.draw2D([v+N[0],b+N[1]+_+A+z+A,_,z],2,NaN,[K,Z]),V){const q=E*N[4];this.draw3D([v+N[0],b+N[1]+_+z+z+A*3,q,q])}}else if(L){if(this.draw2D([v+N[0],b+N[1],Y,_],0,NaN,[W,K]),this.draw2D([v+N[0]+Y+A,b+N[1],Y,z],1,NaN,[W,Z]),this.draw2D([v+N[0]+Y+Y+A*2,b+N[1],_,z],2,NaN,[K,Z]),V){const q=E*N[4];this.draw3D([v+N[0]+Y+Y+_+A*3,b+N[1],q,q])}}else P&&(m||(V=!1),this.opts.multiplanarShowRender===2&&(V=!0),f&&(V=!1),this.draw2D([v+N[0],b+N[1]+z+A,Y,_],0,NaN,[W,K]),this.draw2D([v+N[0],b+N[1],Y,z],1,NaN,[W,Z]),this.draw2D([v+N[0]+Y+A,b+N[1],_,z],2,NaN,[K,Z]),V&&this.draw3D([v+N[0]+Y+A,b+N[1]+z+A,_,_]))}}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),l&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.getCurrentDragMode()===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.getCurrentDragMode()===3&&!this._skipDragInDraw){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;this.getCurrentDragMode()===2&&this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]),this.getCurrentDragMode()===7&&this.drawAngleMeasurementTool();const d=this.getCurrentDragMode();if(d===1||d===6){const f=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),u=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),f,u])}}for(const d of this.document.completedMeasurements)if(this.shouldDrawOnCurrentSlice(d.sliceIndex,d.sliceType,d.slicePosition)){const f=this.mm2frac(d.startMM),u=this.mm2frac(d.endMM),m=this.frac2canvasPosWithTile(f,d.sliceType),p=this.frac2canvasPosWithTile(u,d.sliceType);m&&p&&m.tileIndex===p.tileIndex&&this.drawMeasurementTool([m.pos[0],m.pos[1],p.pos[0],p.pos[1]])}for(let d=0;d<this.document.completedAngles.length;d++){const f=this.document.completedAngles[d];if(this.shouldDrawOnCurrentSlice(f.sliceIndex,f.sliceType,f.slicePosition)){const m=this.mm2frac(f.firstLineMM.start),p=this.mm2frac(f.firstLineMM.end),g=this.mm2frac(f.secondLineMM.start),x=this.mm2frac(f.secondLineMM.end),A=this.frac2canvasPosWithTile(m,f.sliceType),y=this.frac2canvasPosWithTile(p,f.sliceType),v=this.frac2canvasPosWithTile(g,f.sliceType),b=this.frac2canvasPosWithTile(x,f.sliceType);if(A&&y&&v&&b&&A.tileIndex===y.tileIndex&&A.tileIndex===v.tileIndex&&A.tileIndex===b.tileIndex){this.drawMeasurementTool([A.pos[0],A.pos[1],y.pos[0],y.pos[1]],!1),this.drawMeasurementTool([v.pos[0],v.pos[1],b.pos[0],b.pos[1]],!1);const w={firstLine:[A.pos[0],A.pos[1],y.pos[0],y.pos[1]],secondLine:[v.pos[0],v.pos[1],b.pos[0],b.pos[1]],sliceIndex:f.sliceIndex,sliceType:f.sliceType,slicePosition:f.slicePosition};this.drawAngleTextForAngle(w)}}}const c=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return s=c[0].toFixed(2)+"×"+c[1].toFixed(2)+"×"+c[2].toFixed(2),this.readyForSync=!0,this.sync(),this.screenSlices.some(d=>d.axCorSag===4)||this.draw3DLabels(J(),[0,0,0,0],!0),this.drawAnchoredLabels(),this.drawBoundsBorder(),s}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let t=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(t=this.drawScene()),t}r8Tex(t,e,i,r=!1){return Hc(this.gl,t,e,i,r)}r16Tex(t,e,i,r){return Qc(this.gl,t,e,i,r)}r16fTex(t,e,i,r){return Zc(this.gl,t,e,i,r)}rgbaTex2D(t,e,i,r=null,s=!0){return jc(this.gl,t,e,i,r,s)}rgbaTex(t,e,i,r=!1){return _c(this.gl,t,e,i,r)}rgba16Tex(t,e,i,r=!1){return Jc(this.gl,t,e,i,r)}requestCORSIfNotSameOrigin(t,e){xn(t,e)}async loadPngAsTexture(t,e){const i=await $c(this.gl,t,e,this.fontShader,this.bmpShader,this.fontTexture,this.bmpTexture,this.matCapTexture,r=>{this.bmpTextureWH=r});return e===3?this.fontTexture=i:e===4?this.bmpTexture=i:e===5&&(this.matCapTexture=i),this.drawScene(),i}async loadFontTexture(t){return this.loadPngAsTexture(t,3)}async loadBmpTexture(t){return this.loadPngAsTexture(t,4)}async loadMatCapTexture(t){return this.loadPngAsTexture(t,5)}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(t){this._gl=t}findDrawingBoundarySlices(t){if(!this.back||!this.back.dims||!this.drawBitmap)return null;const e={dimX:this.back.dims[1],dimY:this.back.dims[2],dimZ:this.back.dims[3]};return B2(t,this.drawBitmap,e)}interpolateMaskSlices(t,e,i={}){if(!this.back||!this.back.dims||!this.drawBitmap)throw new Error("Background image and drawing bitmap must be loaded");const r={dimX:this.back.dims[1],dimY:this.back.dims[2],dimZ:this.back.dims[3]},s=this.back.img,n=this.back.global_max;N2(this.drawBitmap,r,s,n,t,e,i,()=>this.refreshDrawing(!0))}};ft=new WeakMap;export{ke as DEFAULT_OPTIONS,Nm as DEFAULT_SCENE_DATA,On as DRAG_MODE,mi as INITIAL_SCENE_DATA,Oc as LabelAnchorPoint,kc as LabelLineTerminator,Lc as LabelTextAlignment,Nr as MESH_EXTENSIONS,y0 as MULTIPLANAR_TYPE,St as NVDocument,Me as NVImage,si as NVImageFromUrlOptions,Er as NVLabel3D,Um as NVLabel3DStyle,mt as NVMesh,Rm as NVMeshFromUrlOptions,zc as NVMeshLayerDefaults,ce as NVMeshLoaders,$e as NVMeshUtilities,H as NVUtilities,f0 as NVZarrHelper,Lm as Niivue,Sm as NiivueEvent,v0 as PEN_TYPE,w0 as SHOW_RENDER,x0 as SLICE_TYPE,Kt as ZarrChunkCache,l0 as ZarrChunkClient,n0 as arrayToMat4,re as cmapper,Nc as colortables,pt as copyAffine,s0 as createTransformMatrix,Ui as degToRad,r0 as eulerToRotationMatrix,Lr as getFileExt,Hf as getLoader,_n as getMediaByUrl,ea as handleDragEnter,ta as handleDragOver,Vm as identityTransform,qf as isDicomExtension,jn as isMeshExt,a0 as mat4ToArray,o0 as multiplyAffine,$n as readDirectory,Qf as readFileAsDataURL,Jn as registerLoader,Pm as transformsEqual,kr as traverseFileTree};