@erosolaraijs/cure 3.0.5 → 3.0.7

package/package.json

@@ -1,6 +1,6 @@
 {
   "name": "@erosolaraijs/cure",
-  "version": "3.0.5",
+  "version": "3.0.7",
   "description": "AI-powered unified cancer treatment framework with multi-provider support for medical research and patient care",
   "main": "dist/bin/cure.js",
   "type": "module",

package/src/bin/cure.ts

@@ -755,40 +755,70 @@ async function processInput(input: string): Promise<void> {
     }
     console.log();
 
-    // Run the comprehensive cure protocol
-    await generateCureProtocol(detectedCancer, detectedStage, detectedMutations);
+    // AI-FIRST approach: Use AI as the PRIMARY treatment recommendation engine
+    if (getActiveApiKey()) {
+      console.log(`${colors.cyan}🤖 Consulting ${getActiveModel()} for treatment recommendations...${colors.reset}\n`);
 
-    // Also run clinical trials search
-    console.log(`\n${colors.cyan}🔬 Searching Clinical Trials...${colors.reset}\n`);
-    await findClinicalTrials(detectedCancer, detectedMutations);
+      const aiPrompt = `You are an expert oncologist AI. Generate a comprehensive cancer treatment plan for:
 
-    // Run drug discovery for key targets
-    if (detectedMutations.length > 0) {
-      console.log(`\n${colors.cyan}💊 Analyzing Drug Targets...${colors.reset}\n`);
-      await discoverTargets(detectedMutations[0], detectedCancer);
-    }
+Cancer Type: ${detectedCancer}
+Stage: ${detectedStage}
+${detectedMutations.length > 0 ? `Known Mutations/Biomarkers: ${detectedMutations.join(', ')}` : 'Mutations: Not specified - recommend testing'}
 
-    // Try to enhance with AI analysis (optional - works without API credits)
-    if (getActiveApiKey()) {
-      console.log(`\n${colors.cyan}🤖 AI Analysis...${colors.reset}`);
-      const enhancedPrompt = `Based on the cure protocol, clinical trials, and drug targets shown above for ${detectedCancer} cancer (stage ${detectedStage}${detectedMutations.length > 0 ? `, mutations: ${detectedMutations.join(', ')}` : ''}), provide a brief personalized summary with:
-1. Top 3 recommended treatment approaches in order of priority
-2. Most promising clinical trial categories to explore
-3. Key biomarkers to test if not already done
-4. Expected outcomes with current best treatments
-Keep it concise and actionable.`;
-
-      const aiResponse = await callAI(enhancedPrompt);
-      // Only show AI response if it's not an error
-      if (!aiResponse.includes('API Error') && !aiResponse.includes('credits')) {
-        console.log(`\n${aiResponse}`);
+Provide a structured treatment plan with:
+
+1. **PRIMARY TREATMENT RECOMMENDATION**
+   - First-line therapy with specific drug names and regimens
+   - Rationale based on current guidelines (NCCN, ESMO, ASCO)
+
+2. **TARGETED THERAPIES** (if applicable)
+   - Specific FDA-approved drugs for any detected mutations
+   - Companion diagnostics to order
+
+3. **IMMUNOTHERAPY CONSIDERATIONS**
+   - Checkpoint inhibitors if appropriate (pembrolizumab, nivolumab, etc.)
+   - Biomarkers to test (PD-L1, MSI, TMB)
+
+4. **CLINICAL TRIALS TO CONSIDER**
+   - Mention specific trial categories or approaches worth exploring
+   - Note: Always verify on ClinicalTrials.gov
+
+5. **MONITORING & FOLLOW-UP**
+   - Response assessment schedule
+   - Key biomarkers to track
+
+6. **PROGNOSIS DISCUSSION**
+   - Realistic outcome expectations based on published data
+   - Important: Note this is general information, individual outcomes vary
+
+Be evidence-based and cite specific landmark trials where relevant (e.g., KEYNOTE-189, CheckMate-067, DESTINY-Breast03). Keep response focused and clinically actionable.`;
+
+      const aiResponse = await callAI(aiPrompt);
+
+      // Check if AI response is valid
+      if (!aiResponse.includes('API Error') && !aiResponse.includes('credits') && !aiResponse.includes('API key not set') && !aiResponse.includes('Connection error')) {
+        console.log(`${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}`);
+        console.log(`${colors.green}  AI-GENERATED TREATMENT PLAN (${getActiveModel()})${colors.reset}`);
+        console.log(`${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}\n`);
+        console.log(aiResponse);
+        console.log(`\n${colors.dim}⚠ This is AI-generated guidance. Always consult with treating oncologist.${colors.reset}`);
       } else {
-        console.log(`\n${colors.dim}AI summary skipped (API quota). Protocol complete above.${colors.reset}`);
+        // AI failed - show the actual error
+        console.log(`${colors.red}AI Error: ${aiResponse}${colors.reset}`);
+        console.log(`${colors.yellow}Falling back to local treatment database...${colors.reset}\n`);
+        await generateCureProtocol(detectedCancer, detectedStage, detectedMutations);
       }
     } else {
-      console.log(`\n${colors.dim}Set API key with /key for AI-powered insights.${colors.reset}`);
+      // No API key - use local protocol with clear disclaimer
+      console.log(`${colors.yellow}No API key set - using local treatment database${colors.reset}`);
+      console.log(`${colors.dim}Set API key with /key YOUR_KEY for AI-powered recommendations${colors.reset}\n`);
+      await generateCureProtocol(detectedCancer, detectedStage, detectedMutations);
     }
 
+    // Also run clinical trials search (uses real NCT IDs)
+    console.log(`\n${colors.cyan}🔬 Searching Clinical Trials...${colors.reset}\n`);
+    await findClinicalTrials(detectedCancer, detectedMutations);
+
     console.log(`\n${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}`);
     console.log(`${colors.green}  ✅ CURE PROTOCOL COMPLETE${colors.reset}`);
     console.log(`${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}`);
@@ -882,6 +912,71 @@ async function designTreatmentPlan(patientId: string, protocolId?: string): Prom
 async function generateCureProtocol(cancerType: string, stage: string, mutations: string[]): Promise<void> {
   console.log(`\n${colors.cyan}Generating cure protocol for ${cancerType} cancer, stage ${stage}...${colors.reset}\n`);
 
+  // AI-FIRST APPROACH: Use AI as primary treatment recommendation engine
+  const apiKey = getActiveApiKey();
+  if (apiKey) {
+    console.log(`${colors.cyan}🤖 Consulting ${getActiveModel()} for treatment recommendations...${colors.reset}\n`);
+
+    const aiPrompt = `You are an expert oncologist AI. Generate a comprehensive cancer treatment plan for:
+
+Cancer Type: ${cancerType}
+Stage: ${stage}
+${mutations.length > 0 ? `Known Mutations/Biomarkers: ${mutations.join(', ')}` : 'Mutations: Not specified - recommend testing'}
+
+Provide a structured treatment plan with:
+
+1. **PRIMARY TREATMENT RECOMMENDATION**
+   - First-line therapy with specific drug names and regimens
+   - Rationale based on current guidelines (NCCN, ESMO, ASCO)
+
+2. **TARGETED THERAPIES** (if applicable)
+   - Specific FDA-approved drugs for any detected mutations
+   - Companion diagnostics to order
+
+3. **IMMUNOTHERAPY CONSIDERATIONS**
+   - Checkpoint inhibitors if appropriate (pembrolizumab, nivolumab, etc.)
+   - Biomarkers to test (PD-L1, MSI, TMB)
+
+4. **CLINICAL TRIALS TO CONSIDER**
+   - Mention specific trial categories or approaches worth exploring
+   - Note: Always verify on ClinicalTrials.gov
+
+5. **MONITORING & FOLLOW-UP**
+   - Response assessment schedule
+   - Key biomarkers to track
+
+6. **PROGNOSIS DISCUSSION**
+   - Realistic outcome expectations based on published data
+   - Important: Note this is general information, individual outcomes vary
+
+Be evidence-based and cite specific landmark trials where relevant (e.g., KEYNOTE-189, CheckMate-067, DESTINY-Breast03). Keep response focused and clinically actionable.`;
+
+    try {
+      const aiResponse = await callAI(aiPrompt);
+
+      // Check if AI response is valid (not an error)
+      if (!aiResponse.includes('API Error') && !aiResponse.includes('credits') && !aiResponse.includes('API key not set') && !aiResponse.includes('Connection error')) {
+        console.log(`${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}`);
+        console.log(`${colors.green}  AI-GENERATED TREATMENT PLAN (${getActiveModel()})${colors.reset}`);
+        console.log(`${colors.green}═══════════════════════════════════════════════════════════════${colors.reset}\n`);
+        console.log(aiResponse);
+        console.log(`\n${colors.dim}⚠ This is AI-generated guidance. Always consult with treating oncologist.${colors.reset}`);
+        console.log(`\n${colors.green}✓ AI treatment plan generated${colors.reset}`);
+        return; // Success - exit early
+      } else {
+        // AI call failed - show the actual error
+        console.log(`${colors.red}AI Error: ${aiResponse}${colors.reset}`);
+        console.log(`${colors.yellow}Falling back to local database...${colors.reset}\n`);
+      }
+    } catch (error) {
+      console.log(`${colors.yellow}AI call failed - falling back to local database${colors.reset}\n`);
+    }
+  } else {
+    console.log(`${colors.yellow}No API key set - using local treatment database${colors.reset}`);
+    console.log(`${colors.dim}Set API key with: cure then /key YOUR_API_KEY for AI recommendations${colors.reset}\n`);
+  }
+
+  // FALLBACK: Local treatment database (only if AI unavailable)
   try {
     const genomicProfile = mutations.length > 0 ? {
       mutations,
@@ -894,7 +989,7 @@ async function generateCureProtocol(cancerType: string, stage: string, mutations
 
     const result = await cancerTreatment.cureCancer('CLI-PATIENT', cancerType, stage, genomicProfile);
 
-    console.log(`${colors.bold}${colors.green}CURE PROTOCOL${colors.reset}`);
+    console.log(`${colors.bold}${colors.yellow}LOCAL DATABASE PROTOCOL${colors.reset} ${colors.dim}(AI unavailable)${colors.reset}`);
     console.log(`${colors.dim}═══════════════════════════════════════════${colors.reset}`);
     console.log(`  Cancer Type:    ${colors.yellow}${result.cancerType}${colors.reset}`);
     console.log(`  Stage:          ${colors.yellow}${result.stage}${colors.reset}`);
@@ -921,20 +1016,20 @@ async function generateCureProtocol(cancerType: string, stage: string, mutations
       console.log(`  Drugs:          ${result.immunotherapy.drugs.join(', ')}`);
     }
 
-    console.log(`\n${colors.bold}Projected Outcomes${colors.reset} ${colors.dim}(model estimates, not clinical data)${colors.reset}`);
+    console.log(`\n${colors.bold}Projected Outcomes${colors.reset} ${colors.dim}(database estimates, not clinical data)${colors.reset}`);
     console.log(`  Response Rate:    ${colors.green}${(result.projectedOutcome.responseRate * 100).toFixed(1)}%${colors.reset}`);
     console.log(`  5-Year Survival:  ${colors.green}${(result.projectedOutcome.fiveYearSurvival * 100).toFixed(1)}%${colors.reset}`);
     console.log(`  Quality of Life:  ${colors.green}${(result.projectedOutcome.qualityOfLife * 100).toFixed(1)}%${colors.reset}`);
     console.log(`  Cure Confidence:  ${colors.green}${colors.bold}${(result.projectedOutcome.cureConfidence * 100).toFixed(1)}%${colors.reset}`);
-    console.log(`  ${colors.dim}⚠ These projections are algorithmic estimates based on published data.${colors.reset}`);
-    console.log(`  ${colors.dim}  Actual outcomes vary. Consult oncologist for personalized prognosis.${colors.reset}`);
+    console.log(`  ${colors.dim}⚠ These are database estimates, not AI-generated predictions.${colors.reset}`);
+    console.log(`  ${colors.dim}  Set API key for personalized AI recommendations.${colors.reset}`);
 
     console.log(`\n${colors.bold}Breakthroughs${colors.reset}`);
     result.breakthroughs.forEach((bt) => {
       console.log(`  ${bt}`);
     });
 
-    console.log(`\n${colors.green}✓ Cure protocol generated${colors.reset}`);
+    console.log(`\n${colors.green}✓ Local protocol generated (set API key for AI recommendations)${colors.reset}`);
   } catch (error) {
     console.error(`${colors.red}✗ Protocol generation failed:${colors.reset}`, error);
   }