@erosolaraijs/cure 1.0.4 → 1.0.6

package/src/capabilities/cancerTreatmentCapability.ts

@@ -597,7 +597,402 @@ export class CancerTreatmentCapabilityModule {
       organization: 'NCCN', cancerType: 'HCC', stage: 'III-IV',
       treatmentModalities: ['Atezolizumab + Bevacizumab', 'Lenvatinib', 'Sorafenib', 'Durvalumab + Tremelimumab'],
       efficacyScore: 0.72, sideEffectProfile: ['Hypertension', 'Bleeding', 'Hepatic Decompensation'],
-      references: ['IMbrave150', 'HIMALAYA'] }
+      references: ['IMbrave150', 'HIMALAYA'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // SARCOMAS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-soft-tissue-sarcoma', name: 'Soft Tissue Sarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Soft Tissue Sarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Doxorubicin', 'Ifosfamide', 'Trabectedin', 'Eribulin'],
+      efficacyScore: 0.65, sideEffectProfile: ['Cardiotoxicity', 'Myelosuppression', 'Nausea'],
+      references: ['NCCN STS Guidelines', 'ET743-SAR-3007'] },
+    { id: 'nccn-osteosarcoma', name: 'Osteosarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Osteosarcoma', stage: 'All',
+      treatmentModalities: ['MAP Chemotherapy', 'Surgery', 'Mifamurtide', 'High-dose Methotrexate'],
+      efficacyScore: 0.70, sideEffectProfile: ['Nephrotoxicity', 'Ototoxicity', 'Cardiotoxicity'],
+      references: ['EURAMOS-1', 'INT-0133'] },
+    { id: 'nccn-ewing-sarcoma', name: 'Ewing Sarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Ewing Sarcoma', stage: 'All',
+      treatmentModalities: ['VDC/IE Alternating', 'Surgery', 'Radiation', 'High-dose Chemotherapy'],
+      efficacyScore: 0.72, sideEffectProfile: ['Myelosuppression', 'Nausea', 'Secondary Malignancies'],
+      references: ['COG AEWS1031', 'Euro-EWING 99'] },
+    { id: 'nccn-gist', name: 'GIST Protocol',
+      organization: 'NCCN', cancerType: 'GIST', stage: 'All',
+      treatmentModalities: ['Imatinib', 'Sunitinib', 'Regorafenib', 'Ripretinib', 'Avapritinib'],
+      efficacyScore: 0.85, sideEffectProfile: ['Edema', 'Rash', 'Diarrhea'],
+      references: ['B2222', 'GRID', 'INVICTUS'] },
+    { id: 'nccn-leiomyosarcoma', name: 'Leiomyosarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Leiomyosarcoma', stage: 'All',
+      treatmentModalities: ['Doxorubicin', 'Gemcitabine + Docetaxel', 'Trabectedin', 'Pazopanib'],
+      efficacyScore: 0.55, sideEffectProfile: ['Cardiotoxicity', 'Myelosuppression', 'Hepatotoxicity'],
+      references: ['GeDDiS', 'PALETTE'] },
+    { id: 'nccn-liposarcoma', name: 'Liposarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Liposarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Doxorubicin', 'Eribulin', 'Trabectedin'],
+      efficacyScore: 0.60, sideEffectProfile: ['Myelosuppression', 'Neuropathy', 'Fatigue'],
+      references: ['ET743-SAR-3007', 'E7389-G000-309'] },
+    { id: 'nccn-rhabdomyosarcoma', name: 'Rhabdomyosarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Rhabdomyosarcoma', stage: 'All',
+      treatmentModalities: ['VAC Chemotherapy', 'Radiation', 'Surgery', 'Vincristine + Irinotecan'],
+      efficacyScore: 0.75, sideEffectProfile: ['Myelosuppression', 'Neuropathy', 'Cardiotoxicity'],
+      references: ['COG ARST0531', 'IRS-IV'] },
+    { id: 'nccn-chondrosarcoma', name: 'Chondrosarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Chondrosarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation (dedifferentiated)', 'Clinical Trials'],
+      efficacyScore: 0.50, sideEffectProfile: ['Surgical Complications', 'Radiation-related'],
+      references: ['NCCN Bone Cancer Guidelines'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // PEDIATRIC CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'cog-all', name: 'Pediatric ALL Protocol',
+      organization: 'Other', cancerType: 'Pediatric ALL', stage: 'All',
+      treatmentModalities: ['Induction', 'Consolidation', 'Maintenance', 'CNS Prophylaxis', 'CAR-T (relapsed)'],
+      efficacyScore: 0.92, sideEffectProfile: ['Infections', 'Osteonecrosis', 'Neurotoxicity'],
+      references: ['COG AALL1231', 'Total Therapy XVI'] },
+    { id: 'cog-neuroblastoma', name: 'Neuroblastoma Protocol',
+      organization: 'Other', cancerType: 'Neuroblastoma', stage: 'All',
+      treatmentModalities: ['Induction Chemotherapy', 'Surgery', 'High-dose Chemo + ASCT', 'Immunotherapy', 'Isotretinoin'],
+      efficacyScore: 0.75, sideEffectProfile: ['Myelosuppression', 'Ototoxicity', 'Nephrotoxicity'],
+      references: ['COG ANBL1232', 'HR-NBL1/SIOPEN'] },
+    { id: 'cog-wilms', name: 'Wilms Tumor Protocol',
+      organization: 'Other', cancerType: 'Wilms Tumor', stage: 'All',
+      treatmentModalities: ['Nephrectomy', 'Vincristine + Actinomycin D', 'Doxorubicin (high-risk)', 'Radiation'],
+      efficacyScore: 0.90, sideEffectProfile: ['Hepatotoxicity', 'Cardiotoxicity', 'Second Malignancies'],
+      references: ['COG AREN0532', 'SIOP 2001'] },
+    { id: 'cog-medulloblastoma', name: 'Medulloblastoma Protocol',
+      organization: 'Other', cancerType: 'Medulloblastoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Craniospinal Radiation', 'Cisplatin/Vincristine/Lomustine', 'High-dose Chemo (infant)'],
+      efficacyScore: 0.78, sideEffectProfile: ['Neurocognitive Effects', 'Endocrine Dysfunction', 'Ototoxicity'],
+      references: ['COG ACNS0331', 'SJMB03'] },
+    { id: 'cog-retinoblastoma', name: 'Retinoblastoma Protocol',
+      organization: 'Other', cancerType: 'Retinoblastoma', stage: 'All',
+      treatmentModalities: ['Enucleation', 'Intra-arterial Chemotherapy', 'Intravitreal Melphalan', 'Laser/Cryotherapy'],
+      efficacyScore: 0.95, sideEffectProfile: ['Vision Loss', 'Secondary Malignancies', 'Vascular Complications'],
+      references: ['COG ARET0332'] },
+    { id: 'cog-hepatoblastoma', name: 'Hepatoblastoma Protocol',
+      organization: 'Other', cancerType: 'Hepatoblastoma', stage: 'All',
+      treatmentModalities: ['Cisplatin + Doxorubicin', 'Surgery/Resection', 'Liver Transplant (if needed)'],
+      efficacyScore: 0.82, sideEffectProfile: ['Ototoxicity', 'Cardiotoxicity', 'Nephrotoxicity'],
+      references: ['COG AHEP0731', 'SIOPEL-4'] },
+    { id: 'cog-germ-cell', name: 'Pediatric Germ Cell Tumor Protocol',
+      organization: 'Other', cancerType: 'Pediatric Germ Cell', stage: 'All',
+      treatmentModalities: ['BEP Chemotherapy', 'Surgery', 'Carboplatin-based (low-risk)'],
+      efficacyScore: 0.88, sideEffectProfile: ['Pulmonary Toxicity', 'Nephrotoxicity', 'Infertility'],
+      references: ['COG AGCT0132', 'MaGIC'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // BRAIN TUMORS (Beyond GBM)
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-astrocytoma', name: 'Low-Grade Astrocytoma Protocol',
+      organization: 'NCCN', cancerType: 'Low-Grade Glioma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Observation', 'Temozolomide', 'PCV', 'Radiation'],
+      efficacyScore: 0.80, sideEffectProfile: ['Seizures', 'Cognitive Changes', 'Fatigue'],
+      references: ['RTOG 9802', 'EORTC 22033'] },
+    { id: 'nccn-oligodendroglioma', name: 'Oligodendroglioma Protocol',
+      organization: 'NCCN', cancerType: 'Oligodendroglioma', stage: 'All',
+      treatmentModalities: ['Surgery', 'PCV Chemotherapy', 'Temozolomide', 'Radiation'],
+      efficacyScore: 0.85, sideEffectProfile: ['Myelosuppression', 'Nausea', 'Cognitive Changes'],
+      references: ['RTOG 9402', 'EORTC 26951'] },
+    { id: 'nccn-meningioma', name: 'Meningioma Protocol',
+      organization: 'NCCN', cancerType: 'Meningioma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation/SRS', 'Observation (Grade I)'],
+      efficacyScore: 0.90, sideEffectProfile: ['Surgical Complications', 'Radiation Necrosis'],
+      references: ['RTOG 0539'] },
+    { id: 'nccn-ependymoma', name: 'Ependymoma Protocol',
+      organization: 'NCCN', cancerType: 'Ependymoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Chemotherapy (recurrent)'],
+      efficacyScore: 0.70, sideEffectProfile: ['Neurocognitive Effects', 'Endocrine Dysfunction'],
+      references: ['COG ACNS0831'] },
+    { id: 'nccn-pituitary', name: 'Pituitary Tumor Protocol',
+      organization: 'NCCN', cancerType: 'Pituitary Adenoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Dopamine Agonists', 'Somatostatin Analogs', 'Radiation'],
+      efficacyScore: 0.88, sideEffectProfile: ['Hypopituitarism', 'Visual Changes', 'CSF Leak'],
+      references: ['Endocrine Society Guidelines'] },
+    { id: 'nccn-brain-mets', name: 'Brain Metastases Protocol',
+      organization: 'NCCN', cancerType: 'Brain Metastases', stage: 'IV',
+      treatmentModalities: ['SRS', 'WBRT', 'Surgery', 'Systemic Therapy', 'Immunotherapy'],
+      efficacyScore: 0.60, sideEffectProfile: ['Radiation Necrosis', 'Neurocognitive Decline'],
+      references: ['NCCTG N0574', 'Alliance A071801'] },
+    { id: 'nccn-pcnsl', name: 'Primary CNS Lymphoma Protocol',
+      organization: 'NCCN', cancerType: 'PCNSL', stage: 'All',
+      treatmentModalities: ['High-dose Methotrexate', 'Rituximab', 'Consolidation Chemo/ASCT', 'WBRT'],
+      efficacyScore: 0.65, sideEffectProfile: ['Nephrotoxicity', 'Neurotoxicity', 'Mucositis'],
+      references: ['IELSG32', 'Alliance 51101'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // NEUROENDOCRINE TUMORS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-gi-net', name: 'GI Neuroendocrine Tumor Protocol',
+      organization: 'NCCN', cancerType: 'GI NET', stage: 'All',
+      treatmentModalities: ['Surgery', 'Somatostatin Analogs', 'Everolimus', 'PRRT (Lu-177 DOTATATE)', 'Sunitinib'],
+      efficacyScore: 0.75, sideEffectProfile: ['Diarrhea', 'Hyperglycemia', 'Myelosuppression'],
+      references: ['NETTER-1', 'RADIANT-3', 'CLARINET'] },
+    { id: 'nccn-pancreatic-net', name: 'Pancreatic NET Protocol',
+      organization: 'NCCN', cancerType: 'Pancreatic NET', stage: 'All',
+      treatmentModalities: ['Surgery', 'Everolimus', 'Sunitinib', 'PRRT', 'Temozolomide + Capecitabine'],
+      efficacyScore: 0.72, sideEffectProfile: ['Stomatitis', 'Fatigue', 'Hypertension'],
+      references: ['RADIANT-3', 'A6181111'] },
+    { id: 'nccn-sclc', name: 'Small Cell Lung Cancer Protocol',
+      organization: 'NCCN', cancerType: 'SCLC', stage: 'All',
+      treatmentModalities: ['Carboplatin + Etoposide + Atezolizumab', 'Radiation', 'PCI', 'Topotecan/Lurbinectedin'],
+      efficacyScore: 0.55, sideEffectProfile: ['Myelosuppression', 'Neuropathy', 'Fatigue'],
+      references: ['IMpower133', 'CASPIAN'] },
+    { id: 'nccn-carcinoid', name: 'Carcinoid Tumor Protocol',
+      organization: 'NCCN', cancerType: 'Carcinoid', stage: 'All',
+      treatmentModalities: ['Surgery', 'Octreotide/Lanreotide', 'PRRT', 'Telotristat'],
+      efficacyScore: 0.78, sideEffectProfile: ['Carcinoid Crisis', 'Diarrhea', 'Flushing'],
+      references: ['PROMID', 'TELESTAR'] },
+    { id: 'nccn-pheochromocytoma', name: 'Pheochromocytoma Protocol',
+      organization: 'NCCN', cancerType: 'Pheochromocytoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Alpha-blockade', 'MIBG Therapy', 'CVD Chemotherapy', 'Sunitinib'],
+      efficacyScore: 0.70, sideEffectProfile: ['Hypertensive Crisis', 'Cardiovascular Events'],
+      references: ['NCCN Neuroendocrine Guidelines'] },
+    { id: 'nccn-merkel-cell', name: 'Merkel Cell Carcinoma Protocol',
+      organization: 'NCCN', cancerType: 'Merkel Cell Carcinoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Avelumab', 'Pembrolizumab', 'Chemotherapy'],
+      efficacyScore: 0.68, sideEffectProfile: ['Immune-related AEs', 'Fatigue'],
+      references: ['JAVELIN Merkel 200', 'KEYNOTE-017'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // HEAD AND NECK CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-hnscc', name: 'Head and Neck Squamous Cell Carcinoma Protocol',
+      organization: 'NCCN', cancerType: 'HNSCC', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation + Cisplatin', 'Pembrolizumab', 'Cetuximab', 'Nivolumab'],
+      efficacyScore: 0.72, sideEffectProfile: ['Mucositis', 'Dysphagia', 'Nephrotoxicity'],
+      references: ['KEYNOTE-048', 'CheckMate-141', 'RTOG 0129'] },
+    { id: 'nccn-hpv-positive', name: 'HPV+ Oropharyngeal Cancer Protocol',
+      organization: 'NCCN', cancerType: 'HPV+ OPSCC', stage: 'All',
+      treatmentModalities: ['Surgery + Adjuvant RT', 'Definitive CRT', 'De-escalation Trials'],
+      efficacyScore: 0.88, sideEffectProfile: ['Dysphagia', 'Dry Mouth', 'Neck Fibrosis'],
+      references: ['RTOG 1016', 'De-ESCALaTE'] },
+    { id: 'nccn-nasopharyngeal', name: 'Nasopharyngeal Carcinoma Protocol',
+      organization: 'NCCN', cancerType: 'Nasopharyngeal Carcinoma', stage: 'All',
+      treatmentModalities: ['Concurrent Chemoradiation', 'Induction Chemotherapy', 'Immunotherapy'],
+      efficacyScore: 0.80, sideEffectProfile: ['Hearing Loss', 'Dry Mouth', 'Trismus'],
+      references: ['MAC-NPC', 'CAPTAIN-1st'] },
+    { id: 'nccn-thyroid-differentiated', name: 'Differentiated Thyroid Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Differentiated Thyroid Cancer', stage: 'All',
+      treatmentModalities: ['Thyroidectomy', 'RAI Ablation', 'TSH Suppression', 'Lenvatinib', 'Sorafenib'],
+      efficacyScore: 0.95, sideEffectProfile: ['Hypothyroidism', 'Hypertension', 'Fatigue'],
+      references: ['SELECT', 'DECISION'] },
+    { id: 'nccn-thyroid-medullary', name: 'Medullary Thyroid Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Medullary Thyroid Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Vandetanib', 'Cabozantinib', 'Selpercatinib (RET+)', 'Pralsetinib'],
+      efficacyScore: 0.75, sideEffectProfile: ['QT Prolongation', 'Hypertension', 'Diarrhea'],
+      references: ['ZETA', 'LIBRETTO-001', 'ARROW'] },
+    { id: 'nccn-thyroid-anaplastic', name: 'Anaplastic Thyroid Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Anaplastic Thyroid Cancer', stage: 'All',
+      treatmentModalities: ['Dabrafenib + Trametinib (BRAF+)', 'CRT', 'Lenvatinib', 'Clinical Trials'],
+      efficacyScore: 0.35, sideEffectProfile: ['Rapid Progression', 'Airway Compromise'],
+      references: ['ROAR Basket Trial'] },
+    { id: 'nccn-salivary-gland', name: 'Salivary Gland Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Salivary Gland Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Trastuzumab (HER2+)', 'Androgen Blockade (SDC)'],
+      efficacyScore: 0.65, sideEffectProfile: ['Facial Nerve Injury', 'Dry Mouth'],
+      references: ['NCCN Head and Neck Guidelines'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // ESOPHAGEAL AND GASTRIC CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-esophageal', name: 'Esophageal Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Esophageal Cancer', stage: 'All',
+      treatmentModalities: ['Neoadjuvant CRT + Surgery', 'Definitive CRT', 'Nivolumab', 'Pembrolizumab', 'T-DXd (HER2+)'],
+      efficacyScore: 0.55, sideEffectProfile: ['Esophagitis', 'Dysphagia', 'Pneumonitis'],
+      references: ['CheckMate-577', 'KEYNOTE-590', 'CROSS'] },
+    { id: 'nccn-gastric', name: 'Gastric Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Gastric Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Perioperative FLOT', 'Trastuzumab (HER2+)', 'Nivolumab', 'Pembrolizumab'],
+      efficacyScore: 0.60, sideEffectProfile: ['Nausea', 'Neuropathy', 'Myelosuppression'],
+      references: ['CheckMate-649', 'ToGA', 'FLOT4'] },
+    { id: 'nccn-gej', name: 'GE Junction Cancer Protocol',
+      organization: 'NCCN', cancerType: 'GE Junction Cancer', stage: 'All',
+      treatmentModalities: ['Neoadjuvant CRT', 'Surgery', 'Pembrolizumab + Chemo', 'Nivolumab'],
+      efficacyScore: 0.58, sideEffectProfile: ['Anastomotic Leak', 'Nutritional Deficiency'],
+      references: ['KEYNOTE-590', 'CheckMate-649'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // GYNECOLOGIC CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-cervical', name: 'Cervical Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Cervical Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Concurrent CRT', 'Pembrolizumab', 'Bevacizumab', 'Tisotumab Vedotin'],
+      efficacyScore: 0.70, sideEffectProfile: ['Cystitis', 'Proctitis', 'Lymphedema'],
+      references: ['KEYNOTE-826', 'GOG-240', 'innovaTV 204'] },
+    { id: 'nccn-endometrial', name: 'Endometrial Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Endometrial Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Carboplatin + Paclitaxel', 'Dostarlimab (dMMR)', 'Lenvatinib + Pembrolizumab'],
+      efficacyScore: 0.75, sideEffectProfile: ['Lymphedema', 'Fatigue', 'Hypertension'],
+      references: ['KEYNOTE-775', 'GARNET', 'GOG-209'] },
+    { id: 'nccn-uterine-sarcoma', name: 'Uterine Sarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Uterine Sarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Doxorubicin', 'Gemcitabine + Docetaxel', 'Pazopanib'],
+      efficacyScore: 0.50, sideEffectProfile: ['Cardiotoxicity', 'Myelosuppression'],
+      references: ['GeDDiS'] },
+    { id: 'nccn-vulvar', name: 'Vulvar Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Vulvar Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation + Cisplatin', 'Pembrolizumab'],
+      efficacyScore: 0.68, sideEffectProfile: ['Wound Complications', 'Lymphedema'],
+      references: ['GOG-205'] },
+    { id: 'nccn-vaginal', name: 'Vaginal Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Vaginal Cancer', stage: 'All',
+      treatmentModalities: ['Radiation + Brachytherapy', 'Surgery (early)', 'Chemotherapy'],
+      efficacyScore: 0.65, sideEffectProfile: ['Vaginal Stenosis', 'Bladder/Rectal Toxicity'],
+      references: ['NCCN Vaginal Guidelines'] },
+    { id: 'nccn-gtd', name: 'Gestational Trophoblastic Disease Protocol',
+      organization: 'NCCN', cancerType: 'GTD', stage: 'All',
+      treatmentModalities: ['Methotrexate (low-risk)', 'EMA-CO (high-risk)', 'EP-EMA'],
+      efficacyScore: 0.95, sideEffectProfile: ['Mucositis', 'Myelosuppression', 'Pulmonary Toxicity'],
+      references: ['NCCN GTD Guidelines'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // GENITOURINARY CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-bladder', name: 'Bladder Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Bladder Cancer', stage: 'All',
+      treatmentModalities: ['TURBT', 'BCG', 'Radical Cystectomy', 'Enfortumab Vedotin + Pembrolizumab', 'Erdafitinib (FGFR+)'],
+      efficacyScore: 0.72, sideEffectProfile: ['Cystitis', 'Neuropathy', 'Skin Toxicity'],
+      references: ['EV-302', 'BLC2001', 'KEYNOTE-057'] },
+    { id: 'nccn-testicular', name: 'Testicular Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Testicular Cancer', stage: 'All',
+      treatmentModalities: ['Orchiectomy', 'BEP Chemotherapy', 'Surveillance', 'RPLND', 'High-dose Chemo + ASCT'],
+      efficacyScore: 0.95, sideEffectProfile: ['Pulmonary Toxicity', 'Nephrotoxicity', 'Infertility'],
+      references: ['NCCN Testicular Guidelines', 'SWENOTECA'] },
+    { id: 'nccn-penile', name: 'Penile Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Penile Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'TIP Chemotherapy', 'Pembrolizumab'],
+      efficacyScore: 0.60, sideEffectProfile: ['Functional Impairment', 'Lymphedema'],
+      references: ['NCCN Penile Guidelines'] },
+    { id: 'nccn-adrenocortical', name: 'Adrenocortical Carcinoma Protocol',
+      organization: 'NCCN', cancerType: 'Adrenocortical Carcinoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Mitotane', 'EDP-M Chemotherapy', 'Pembrolizumab'],
+      efficacyScore: 0.45, sideEffectProfile: ['Adrenal Insufficiency', 'Neurotoxicity', 'GI Toxicity'],
+      references: ['FIRM-ACT', 'ADIUVO'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // MORE HEMATOLOGIC MALIGNANCIES
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-cll', name: 'CLL Protocol',
+      organization: 'NCCN', cancerType: 'CLL', stage: 'All',
+      treatmentModalities: ['Ibrutinib', 'Venetoclax + Obinutuzumab', 'Acalabrutinib', 'Zanubrutinib', 'CAR-T (relapsed)'],
+      efficacyScore: 0.90, sideEffectProfile: ['Atrial Fibrillation', 'Bleeding', 'Infections'],
+      references: ['RESONATE-2', 'CLL14', 'ELEVATE-TN'] },
+    { id: 'nccn-cml', name: 'CML Protocol',
+      organization: 'NCCN', cancerType: 'CML', stage: 'All',
+      treatmentModalities: ['Imatinib', 'Dasatinib', 'Nilotinib', 'Bosutinib', 'Ponatinib', 'Asciminib'],
+      efficacyScore: 0.95, sideEffectProfile: ['Fluid Retention', 'Myelosuppression', 'Pleural Effusion'],
+      references: ['IRIS', 'DASISION', 'ENESTnd'] },
+    { id: 'nccn-hodgkin', name: 'Hodgkin Lymphoma Protocol',
+      organization: 'NCCN', cancerType: 'Hodgkin Lymphoma', stage: 'All',
+      treatmentModalities: ['ABVD', 'Brentuximab Vedotin + AVD', 'Pembrolizumab', 'ASCT', 'Nivolumab'],
+      efficacyScore: 0.88, sideEffectProfile: ['Pulmonary Toxicity', 'Cardiotoxicity', 'Secondary Malignancies'],
+      references: ['ECHELON-1', 'KEYNOTE-204', 'CheckMate-205'] },
+    { id: 'nccn-follicular', name: 'Follicular Lymphoma Protocol',
+      organization: 'NCCN', cancerType: 'Follicular Lymphoma', stage: 'All',
+      treatmentModalities: ['Rituximab + Bendamustine', 'R-CHOP', 'Obinutuzumab', 'Lenalidomide + Rituximab', 'CAR-T'],
+      efficacyScore: 0.85, sideEffectProfile: ['Infections', 'Infusion Reactions', 'Cytopenias'],
+      references: ['GALLIUM', 'RELEVANCE', 'ZUMA-5'] },
+    { id: 'nccn-mantle-cell', name: 'Mantle Cell Lymphoma Protocol',
+      organization: 'NCCN', cancerType: 'Mantle Cell Lymphoma', stage: 'All',
+      treatmentModalities: ['R-CHOP/R-DHAP + ASCT', 'Ibrutinib', 'Acalabrutinib', 'Venetoclax', 'Brexucabtagene autoleucel'],
+      efficacyScore: 0.75, sideEffectProfile: ['Myelosuppression', 'Infections', 'Bleeding'],
+      references: ['TRIANGLE', 'ZUMA-2'] },
+    { id: 'nccn-marginal-zone', name: 'Marginal Zone Lymphoma Protocol',
+      organization: 'NCCN', cancerType: 'Marginal Zone Lymphoma', stage: 'All',
+      treatmentModalities: ['Rituximab', 'Bendamustine + Rituximab', 'Ibrutinib', 'Zanubrutinib'],
+      efficacyScore: 0.82, sideEffectProfile: ['Infections', 'Cytopenias'],
+      references: ['MAGNOLIA', 'NCCN MZL Guidelines'] },
+    { id: 'nccn-waldenstrom', name: 'Waldenström Macroglobulinemia Protocol',
+      organization: 'NCCN', cancerType: 'Waldenström Macroglobulinemia', stage: 'All',
+      treatmentModalities: ['Ibrutinib', 'Zanubrutinib', 'Rituximab + Bendamustine', 'Bortezomib-based'],
+      efficacyScore: 0.85, sideEffectProfile: ['Atrial Fibrillation', 'Bleeding', 'IgM Flare'],
+      references: ['ASPEN', 'iNNOVATE'] },
+    { id: 'nccn-hairy-cell', name: 'Hairy Cell Leukemia Protocol',
+      organization: 'NCCN', cancerType: 'Hairy Cell Leukemia', stage: 'All',
+      treatmentModalities: ['Cladribine', 'Pentostatin', 'Vemurafenib (BRAF+)', 'Rituximab'],
+      efficacyScore: 0.92, sideEffectProfile: ['Myelosuppression', 'Infections', 'Immunosuppression'],
+      references: ['NCCN HCL Guidelines'] },
+    { id: 'nccn-mds', name: 'MDS Protocol',
+      organization: 'NCCN', cancerType: 'MDS', stage: 'All',
+      treatmentModalities: ['Azacitidine', 'Decitabine', 'Lenalidomide (del5q)', 'Luspatercept', 'Allogeneic HSCT'],
+      efficacyScore: 0.60, sideEffectProfile: ['Cytopenias', 'Infections', 'Fatigue'],
+      references: ['AZA-001', 'MDS-003'] },
+    { id: 'nccn-mpn', name: 'Myeloproliferative Neoplasms Protocol',
+      organization: 'NCCN', cancerType: 'MPN', stage: 'All',
+      treatmentModalities: ['Hydroxyurea', 'Ruxolitinib', 'Fedratinib', 'Interferon-alpha', 'Allogeneic HSCT'],
+      efficacyScore: 0.70, sideEffectProfile: ['Anemia', 'Thrombocytopenia', 'Infections'],
+      references: ['COMFORT-I/II', 'JAKARTA'] },
+    { id: 'nccn-mastocytosis', name: 'Systemic Mastocytosis Protocol',
+      organization: 'NCCN', cancerType: 'Systemic Mastocytosis', stage: 'All',
+      treatmentModalities: ['Avapritinib', 'Midostaurin', 'Cladribine', 'Imatinib'],
+      efficacyScore: 0.75, sideEffectProfile: ['Edema', 'Nausea', 'Cognitive Effects'],
+      references: ['EXPLORER', 'PIONEER'] },
+
+    // ═══════════════════════════════════════════════════════════════════════════════
+    // RARE CANCERS
+    // ═══════════════════════════════════════════════════════════════════════════════
+    { id: 'nccn-cholangiocarcinoma', name: 'Cholangiocarcinoma Protocol',
+      organization: 'NCCN', cancerType: 'Cholangiocarcinoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Gemcitabine + Cisplatin + Durvalumab', 'Pemigatinib (FGFR2+)', 'Ivosidenib (IDH1+)'],
+      efficacyScore: 0.55, sideEffectProfile: ['Cholangitis', 'Fatigue', 'Hyperphosphatemia'],
+      references: ['TOPAZ-1', 'FIGHT-202', 'ClarIDHy'] },
+    { id: 'nccn-gallbladder', name: 'Gallbladder Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Gallbladder Cancer', stage: 'All',
+      treatmentModalities: ['Surgery', 'Gemcitabine + Cisplatin', 'Capecitabine (adjuvant)'],
+      efficacyScore: 0.45, sideEffectProfile: ['Biliary Complications', 'Nausea'],
+      references: ['BILCAP', 'ABC-02'] },
+    { id: 'nccn-mesothelioma', name: 'Mesothelioma Protocol',
+      organization: 'NCCN', cancerType: 'Mesothelioma', stage: 'All',
+      treatmentModalities: ['Surgery (selected)', 'Cisplatin + Pemetrexed', 'Nivolumab + Ipilimumab', 'TTFields'],
+      efficacyScore: 0.50, sideEffectProfile: ['Pulmonary Toxicity', 'Fatigue', 'Immune-related AEs'],
+      references: ['CheckMate-743', 'STELLAR'] },
+    { id: 'nccn-thymoma', name: 'Thymoma/Thymic Carcinoma Protocol',
+      organization: 'NCCN', cancerType: 'Thymoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'CAP Chemotherapy', 'Sunitinib', 'Pembrolizumab'],
+      efficacyScore: 0.70, sideEffectProfile: ['Myasthenia Gravis', 'Autoimmune Phenomena'],
+      references: ['NCCN Thymoma Guidelines'] },
+    { id: 'nccn-appendiceal', name: 'Appendiceal Cancer Protocol',
+      organization: 'NCCN', cancerType: 'Appendiceal Cancer', stage: 'All',
+      treatmentModalities: ['CRS + HIPEC', 'Systemic Chemotherapy (FOLFOX)', 'Bevacizumab'],
+      efficacyScore: 0.65, sideEffectProfile: ['Surgical Complications', 'Myelosuppression'],
+      references: ['NCCN Colon Guidelines'] },
+    { id: 'nccn-cup', name: 'Cancer of Unknown Primary Protocol',
+      organization: 'NCCN', cancerType: 'CUP', stage: 'All',
+      treatmentModalities: ['Empiric Chemotherapy', 'Site-directed Therapy', 'Immunotherapy', 'Molecular-guided'],
+      efficacyScore: 0.40, sideEffectProfile: ['Varies by Regimen'],
+      references: ['NCCN CUP Guidelines', 'CUPISCO'] },
+    { id: 'nccn-paraganglioma', name: 'Paraganglioma Protocol',
+      organization: 'NCCN', cancerType: 'Paraganglioma', stage: 'All',
+      treatmentModalities: ['Surgery', 'PRRT', 'CVD Chemotherapy', 'Sunitinib', 'Temozolomide'],
+      efficacyScore: 0.65, sideEffectProfile: ['Catecholamine Crisis', 'Myelosuppression'],
+      references: ['FIRSTMAPPP'] },
+    { id: 'nccn-desmoid', name: 'Desmoid Tumor Protocol',
+      organization: 'NCCN', cancerType: 'Desmoid Tumor', stage: 'All',
+      treatmentModalities: ['Active Surveillance', 'Sorafenib', 'Nirogacestat', 'Surgery (selected)'],
+      efficacyScore: 0.70, sideEffectProfile: ['Diarrhea', 'Rash', 'Ovarian Toxicity'],
+      references: ['DeFi', 'Alliance A091105'] },
+    { id: 'nccn-dermatofibrosarcoma', name: 'DFSP Protocol',
+      organization: 'NCCN', cancerType: 'DFSP', stage: 'All',
+      treatmentModalities: ['Wide Local Excision', 'Mohs Surgery', 'Imatinib (unresectable)'],
+      efficacyScore: 0.85, sideEffectProfile: ['Surgical Complications', 'Edema'],
+      references: ['NCCN Dermatofibrosarcoma Guidelines'] },
+    { id: 'nccn-epithelioid-sarcoma', name: 'Epithelioid Sarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Epithelioid Sarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Tazemetostat (INI1-)', 'Doxorubicin', 'Gemcitabine'],
+      efficacyScore: 0.55, sideEffectProfile: ['Myelosuppression', 'Fatigue'],
+      references: ['NCCN STS Guidelines'] },
+    { id: 'nccn-angiosarcoma', name: 'Angiosarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Angiosarcoma', stage: 'All',
+      treatmentModalities: ['Surgery', 'Radiation', 'Paclitaxel', 'Doxorubicin', 'Bevacizumab'],
+      efficacyScore: 0.45, sideEffectProfile: ['Bleeding', 'Cardiotoxicity', 'Myelosuppression'],
+      references: ['ANGIOTAX'] },
+    { id: 'nccn-kaposi', name: 'Kaposi Sarcoma Protocol',
+      organization: 'NCCN', cancerType: 'Kaposi Sarcoma', stage: 'All',
+      treatmentModalities: ['ART Optimization', 'Liposomal Doxorubicin', 'Paclitaxel', 'Pomalidomide'],
+      efficacyScore: 0.75, sideEffectProfile: ['Myelosuppression', 'Cardiotoxicity'],
+      references: ['AIDS Malignancy Consortium'] }
   ];
 
   constructor() {
@@ -805,20 +1200,118 @@ export class CancerTreatmentCapabilityModule {
     return result;
   }
 
-  // Helper: Normalize cancer type names
+  // Helper: Normalize cancer type names - Comprehensive mapping for all cancer types
   private normalizeCancerType(cancerType: string): string {
     const mappings: Record<string, string> = {
-      'breast': 'Breast', 'lung': 'NSCLC', 'nsclc': 'NSCLC', 'sclc': 'SCLC',
-      'colorectal': 'Colorectal', 'colon': 'Colorectal', 'rectal': 'Colorectal',
-      'melanoma': 'Melanoma', 'pancreatic': 'Pancreatic', 'pancreas': 'Pancreatic',
-      'prostate': 'Prostate', 'ovarian': 'Ovarian', 'renal': 'RCC', 'kidney': 'RCC',
-      'liver': 'HCC', 'hcc': 'HCC', 'hepatocellular': 'HCC',
-      'aml': 'AML', 'leukemia': 'AML', 'lymphoma': 'DLBCL', 'dlbcl': 'DLBCL',
-      'myeloma': 'Multiple Myeloma', 'glioblastoma': 'Glioblastoma', 'gbm': 'Glioblastoma',
-      'bladder': 'Bladder', 'gastric': 'Gastric', 'stomach': 'Gastric',
-      'thyroid': 'Thyroid', 'tnbc': 'TNBC', 'triple negative': 'TNBC'
+      // Common solid tumors
+      'breast': 'Breast', 'breast cancer': 'Breast',
+      'lung': 'NSCLC', 'nsclc': 'NSCLC', 'non-small cell lung': 'NSCLC',
+      'sclc': 'SCLC', 'small cell lung': 'SCLC',
+      'colorectal': 'Colorectal', 'colon': 'Colorectal', 'rectal': 'Colorectal', 'crc': 'Colorectal',
+      'melanoma': 'Melanoma', 'skin melanoma': 'Melanoma',
+      'pancreatic': 'Pancreatic', 'pancreas': 'Pancreatic', 'pdac': 'Pancreatic',
+      'prostate': 'Prostate', 'prostate cancer': 'Prostate',
+      'ovarian': 'Ovarian', 'ovary': 'Ovarian',
+      'renal': 'RCC', 'kidney': 'RCC', 'rcc': 'RCC', 'clear cell renal': 'RCC',
+      'liver': 'HCC', 'hcc': 'HCC', 'hepatocellular': 'HCC', 'hepatocellular carcinoma': 'HCC',
+      'tnbc': 'TNBC', 'triple negative': 'TNBC', 'triple-negative breast': 'TNBC',
+
+      // Hematologic malignancies
+      'aml': 'AML', 'acute myeloid leukemia': 'AML',
+      'all': 'ALL', 'acute lymphoblastic leukemia': 'ALL', 'b-all': 'B-ALL', 'b-cell all': 'B-ALL',
+      'cll': 'CLL', 'chronic lymphocytic leukemia': 'CLL',
+      'cml': 'CML', 'chronic myeloid leukemia': 'CML', 'chronic myelogenous': 'CML',
+      'lymphoma': 'DLBCL', 'dlbcl': 'DLBCL', 'diffuse large b-cell': 'DLBCL',
+      'hodgkin': 'Hodgkin Lymphoma', 'hodgkin lymphoma': 'Hodgkin Lymphoma', 'hl': 'Hodgkin Lymphoma',
+      'follicular': 'Follicular Lymphoma', 'follicular lymphoma': 'Follicular Lymphoma', 'fl': 'Follicular Lymphoma',
+      'mantle cell': 'Mantle Cell Lymphoma', 'mcl': 'Mantle Cell Lymphoma',
+      'marginal zone': 'Marginal Zone Lymphoma', 'mzl': 'Marginal Zone Lymphoma',
+      'myeloma': 'Multiple Myeloma', 'multiple myeloma': 'Multiple Myeloma', 'mm': 'Multiple Myeloma',
+      'waldenstrom': 'Waldenström Macroglobulinemia', 'waldenström': 'Waldenström Macroglobulinemia',
+      'hairy cell': 'Hairy Cell Leukemia', 'hcl': 'Hairy Cell Leukemia',
+      'mds': 'MDS', 'myelodysplastic': 'MDS', 'myelodysplastic syndrome': 'MDS',
+      'mpn': 'MPN', 'myeloproliferative': 'MPN', 'polycythemia vera': 'MPN', 'essential thrombocythemia': 'MPN',
+      'mastocytosis': 'Mastocytosis', 'systemic mastocytosis': 'Mastocytosis',
+
+      // Brain tumors
+      'glioblastoma': 'Glioblastoma', 'gbm': 'Glioblastoma', 'glioblastoma multiforme': 'Glioblastoma',
+      'astrocytoma': 'Low-Grade Astrocytoma', 'low grade astrocytoma': 'Low-Grade Astrocytoma',
+      'oligodendroglioma': 'Oligodendroglioma', 'oligo': 'Oligodendroglioma',
+      'meningioma': 'Meningioma',
+      'ependymoma': 'Ependymoma',
+      'pituitary': 'Pituitary Tumor', 'pituitary adenoma': 'Pituitary Tumor', 'pituitary tumor': 'Pituitary Tumor',
+      'brain metastases': 'Brain Metastases', 'brain mets': 'Brain Metastases',
+      'pcnsl': 'PCNSL', 'primary cns lymphoma': 'PCNSL', 'cns lymphoma': 'PCNSL',
+      'medulloblastoma': 'Medulloblastoma',
+
+      // Sarcomas
+      'sarcoma': 'Soft Tissue Sarcoma', 'soft tissue sarcoma': 'Soft Tissue Sarcoma', 'sts': 'Soft Tissue Sarcoma',
+      'osteosarcoma': 'Osteosarcoma', 'bone cancer': 'Osteosarcoma',
+      'ewing': 'Ewing Sarcoma', 'ewing sarcoma': 'Ewing Sarcoma', 'ewings': 'Ewing Sarcoma',
+      'gist': 'GIST', 'gastrointestinal stromal': 'GIST',
+      'leiomyosarcoma': 'Leiomyosarcoma', 'lms': 'Leiomyosarcoma',
+      'liposarcoma': 'Liposarcoma', 'lipo': 'Liposarcoma',
+      'rhabdomyosarcoma': 'Rhabdomyosarcoma', 'rms': 'Rhabdomyosarcoma',
+      'chondrosarcoma': 'Chondrosarcoma',
+      'angiosarcoma': 'Angiosarcoma',
+      'epithelioid sarcoma': 'Epithelioid Sarcoma',
+      'desmoid': 'Desmoid Tumor', 'desmoid tumor': 'Desmoid Tumor', 'aggressive fibromatosis': 'Desmoid Tumor',
+      'dfsp': 'DFSP', 'dermatofibrosarcoma': 'DFSP',
+
+      // Pediatric cancers
+      'neuroblastoma': 'Neuroblastoma', 'nbl': 'Neuroblastoma',
+      'wilms': 'Wilms Tumor', 'wilms tumor': 'Wilms Tumor', 'nephroblastoma': 'Wilms Tumor',
+      'retinoblastoma': 'Retinoblastoma', 'rb': 'Retinoblastoma',
+      'hepatoblastoma': 'Hepatoblastoma',
+      'pediatric all': 'Pediatric ALL', 'childhood leukemia': 'Pediatric ALL',
+      'pediatric germ cell': 'Pediatric Germ Cell', 'childhood germ cell': 'Pediatric Germ Cell',
+
+      // Neuroendocrine tumors
+      'net': 'GI NET', 'neuroendocrine': 'GI NET', 'neuroendocrine tumor': 'GI NET', 'gi net': 'GI NET',
+      'pancreatic net': 'Pancreatic NET', 'pnet': 'Pancreatic NET', 'p-net': 'Pancreatic NET',
+      'carcinoid': 'Carcinoid', 'carcinoid tumor': 'Carcinoid',
+      'pheochromocytoma': 'Pheochromocytoma', 'pheo': 'Pheochromocytoma',
+      'paraganglioma': 'Paraganglioma', 'pgl': 'Paraganglioma',
+      'merkel': 'Merkel Cell Carcinoma', 'merkel cell': 'Merkel Cell Carcinoma', 'mcc': 'Merkel Cell Carcinoma',
+
+      // Head and neck cancers
+      'head and neck': 'HNSCC', 'hnscc': 'HNSCC', 'head neck': 'HNSCC', 'squamous head neck': 'HNSCC',
+      'hpv positive': 'HPV+ OPSCC', 'hpv+ opscc': 'HPV+ OPSCC', 'oropharyngeal': 'HPV+ OPSCC',
+      'nasopharyngeal': 'Nasopharyngeal', 'npc': 'Nasopharyngeal', 'nasopharynx': 'Nasopharyngeal',
+      'thyroid': 'Differentiated Thyroid', 'differentiated thyroid': 'Differentiated Thyroid', 'papillary thyroid': 'Differentiated Thyroid',
+      'medullary thyroid': 'Medullary Thyroid', 'mtc': 'Medullary Thyroid',
+      'anaplastic thyroid': 'Anaplastic Thyroid', 'atc': 'Anaplastic Thyroid',
+      'salivary': 'Salivary Gland', 'salivary gland': 'Salivary Gland',
+
+      // Gastrointestinal cancers
+      'gastric': 'Gastric', 'stomach': 'Gastric', 'stomach cancer': 'Gastric',
+      'esophageal': 'Esophageal', 'esophagus': 'Esophageal',
+      'ge junction': 'GE Junction', 'gej': 'GE Junction', 'gastroesophageal': 'GE Junction',
+      'cholangiocarcinoma': 'Cholangiocarcinoma', 'bile duct': 'Cholangiocarcinoma', 'cca': 'Cholangiocarcinoma',
+      'gallbladder': 'Gallbladder Cancer', 'gallbladder cancer': 'Gallbladder Cancer',
+      'appendiceal': 'Appendiceal Cancer', 'appendix': 'Appendiceal Cancer',
+
+      // Gynecologic cancers
+      'cervical': 'Cervical', 'cervix': 'Cervical', 'cervical cancer': 'Cervical',
+      'endometrial': 'Endometrial', 'uterine': 'Endometrial', 'uterus': 'Endometrial',
+      'uterine sarcoma': 'Uterine Sarcoma',
+      'vulvar': 'Vulvar', 'vulva': 'Vulvar',
+      'vaginal': 'Vaginal', 'vagina': 'Vaginal',
+      'gtd': 'GTD', 'gestational trophoblastic': 'GTD', 'choriocarcinoma': 'GTD',
+
+      // Genitourinary cancers
+      'bladder': 'Bladder', 'urothelial': 'Bladder', 'bladder cancer': 'Bladder',
+      'testicular': 'Testicular', 'testis': 'Testicular', 'germ cell tumor': 'Testicular',
+      'penile': 'Penile', 'penis': 'Penile',
+      'adrenocortical': 'Adrenocortical Carcinoma', 'acc': 'Adrenocortical Carcinoma', 'adrenal': 'Adrenocortical Carcinoma',
+
+      // Rare cancers
+      'mesothelioma': 'Mesothelioma', 'pleural mesothelioma': 'Mesothelioma',
+      'thymoma': 'Thymoma', 'thymic': 'Thymoma',
+      'cup': 'CUP', 'cancer unknown primary': 'CUP', 'unknown primary': 'CUP',
+      'kaposi': 'Kaposi Sarcoma', 'kaposi sarcoma': 'Kaposi Sarcoma', 'ks': 'Kaposi Sarcoma'
     };
-    const lower = cancerType.toLowerCase();
+    const lower = cancerType.toLowerCase().trim();
     return mappings[lower] || cancerType;
   }