@erosolaraijs/cure 1.0.2 → 1.0.3

package/dist/bin/cure.d.ts

@@ -1,7 +1,7 @@
 #!/usr/bin/env node
 /**
  * Cure - AI Cancer Treatment Framework
- * Interactive CLI for precision oncology research and clinical decision support
+ * Interactive CLI powered by xAI Grok for precision oncology
  */
 export {};
 //# sourceMappingURL=cure.d.ts.map

package/dist/bin/cure.js

@@ -1,11 +1,13 @@
 #!/usr/bin/env node
 /**
  * Cure - AI Cancer Treatment Framework
- * Interactive CLI for precision oncology research and clinical decision support
+ * Interactive CLI powered by xAI Grok for precision oncology
  */
 import * as readline from 'readline';
+import * as https from 'https';
 import { CancerTreatmentCapabilityModule } from '../capabilities/cancerTreatmentCapability.js';
-const VERSION = '1.0.2';
+const VERSION = '1.0.3';
+const XAI_MODEL = 'grok-4-1-fast-reasoning';
 // ANSI color codes
 const colors = {
     reset: '\x1b[0m',
@@ -20,21 +22,111 @@ const colors = {
     white: '\x1b[37m',
 };
 let cancerTreatment;
+let conversationHistory = [];
+const SYSTEM_PROMPT = `You are Cure, an advanced AI oncologist assistant powered by the Cure Cancer Treatment Framework. You help doctors, researchers, and patients with:
+
+1. Cancer diagnosis and staging analysis
+2. Personalized treatment planning (chemotherapy, immunotherapy, targeted therapy, CAR-T)
+3. Drug target discovery and mechanism analysis
+4. Clinical trial matching and eligibility
+5. Genomic biomarker interpretation (EGFR, KRAS, BRAF, HER2, PD-L1, etc.)
+6. Treatment response prediction and survival analysis
+7. Drug interaction and safety checks
+8. HIPAA-compliant patient data handling
+
+You have deep knowledge of:
+- NCCN, ESMO, ASCO treatment guidelines
+- FDA-approved cancer therapies and their mechanisms
+- Precision medicine and molecular oncology
+- Immunotherapy (checkpoint inhibitors, CAR-T, TILs)
+- Targeted therapies for driver mutations
+- Clinical trial design and interpretation
+
+Be concise, scientifically accurate, and clinically relevant. When discussing specific treatments, cite evidence levels and relevant trials. Always recommend consulting with treating oncologists for actual patient care decisions.
+
+Available commands the user can run:
+- /analyze [patient_id] - Analyze patient data
+- /plan [patient_id] - Design treatment plan
+- /discover [gene] [cancer] - Drug target discovery
+- /demo - Run framework demonstration
+- /help - Show available commands`;
+async function callXAI(userMessage) {
+    const apiKey = process.env.XAI_API_KEY;
+    if (!apiKey) {
+        return `${colors.yellow}Note: Set XAI_API_KEY environment variable for AI-powered responses.${colors.reset}\n\nI can help you with cancer treatment analysis. Try:\n  /analyze P001 - Analyze patient\n  /plan P001 - Design treatment plan\n  /discover EGFR Lung - Find drug targets\n  /demo - Run demonstration`;
+    }
+    conversationHistory.push({ role: 'user', content: userMessage });
+    const messages = [
+        { role: 'system', content: SYSTEM_PROMPT },
+        ...conversationHistory
+    ];
+    const requestBody = JSON.stringify({
+        model: XAI_MODEL,
+        messages: messages,
+        temperature: 0.7,
+        max_tokens: 2048
+    });
+    return new Promise((resolve, reject) => {
+        const options = {
+            hostname: 'api.x.ai',
+            port: 443,
+            path: '/v1/chat/completions',
+            method: 'POST',
+            headers: {
+                'Content-Type': 'application/json',
+                'Authorization': `Bearer ${apiKey}`,
+                'Content-Length': Buffer.byteLength(requestBody)
+            }
+        };
+        const req = https.request(options, (res) => {
+            let data = '';
+            res.on('data', (chunk) => { data += chunk; });
+            res.on('end', () => {
+                try {
+                    const response = JSON.parse(data);
+                    if (response.choices && response.choices[0]?.message?.content) {
+                        const assistantMessage = response.choices[0].message.content;
+                        conversationHistory.push({ role: 'assistant', content: assistantMessage });
+                        // Keep conversation history manageable
+                        if (conversationHistory.length > 20) {
+                            conversationHistory = conversationHistory.slice(-16);
+                        }
+                        resolve(assistantMessage);
+                    }
+                    else if (response.error) {
+                        resolve(`${colors.red}API Error: ${response.error.message}${colors.reset}`);
+                    }
+                    else {
+                        resolve(`${colors.red}Unexpected response format${colors.reset}`);
+                    }
+                }
+                catch (e) {
+                    resolve(`${colors.red}Failed to parse response${colors.reset}`);
+                }
+            });
+        });
+        req.on('error', (e) => {
+            resolve(`${colors.red}Connection error: ${e.message}${colors.reset}`);
+        });
+        req.setTimeout(30000, () => {
+            req.destroy();
+            resolve(`${colors.yellow}Request timed out. Try again.${colors.reset}`);
+        });
+        req.write(requestBody);
+        req.end();
+    });
+}
 async function main() {
     const args = process.argv.slice(2);
-    // Check for version flag
     if (args.includes('--version') || args.includes('-v')) {
         console.log(`cure v${VERSION}`);
         process.exit(0);
     }
-    // Check for help flag
     if (args.includes('--help') || args.includes('-h')) {
         printHelp();
         process.exit(0);
     }
-    // Initialize module
     cancerTreatment = new CancerTreatmentCapabilityModule();
-    // Handle direct commands or launch interactive mode
     if (args.length > 0) {
         await handleCommand(args);
     }
@@ -52,7 +144,11 @@ async function launchInteractiveMode() {
     const prompt = () => {
         process.stdout.write(`\n${colors.cyan}cure${colors.reset} ${colors.dim}>${colors.reset} `);
     };
-    console.log(`${colors.dim}Type a command or describe what you need. Type /help for commands.${colors.reset}\n`);
+    const modelInfo = process.env.XAI_API_KEY
+        ? `${colors.green}Connected to xAI ${XAI_MODEL}${colors.reset}`
+        : `${colors.yellow}Set XAI_API_KEY for AI responses${colors.reset}`;
+    console.log(`${colors.dim}${modelInfo}${colors.reset}`);
+    console.log(`${colors.dim}Type your question or /help for commands.${colors.reset}\n`);
     prompt();
     rl.on('line', async (input) => {
         const trimmed = input.trim();
@@ -73,6 +169,8 @@ async function launchInteractiveMode() {
         if (trimmed === '/clear') {
             console.clear();
             printBanner();
+            conversationHistory = [];
+            console.log(`${colors.dim}Conversation cleared.${colors.reset}`);
             prompt();
             return;
         }
@@ -84,7 +182,6 @@ async function launchInteractiveMode() {
     });
 }
 async function processInput(input) {
-    const lower = input.toLowerCase();
     // Slash commands
     if (input.startsWith('/')) {
         const parts = input.slice(1).split(' ');
@@ -93,67 +190,33 @@ async function processInput(input) {
         switch (cmd) {
             case 'analyze':
                 await analyzePatient(args[0] || 'P001', args.includes('--genomics'));
-                break;
+                return;
             case 'plan':
                 await designTreatmentPlan(args[0] || 'P001', args[1]);
-                break;
+                return;
             case 'discover':
                 await discoverTargets(args[0] || 'EGFR', args[1] || 'Lung');
-                break;
+                return;
             case 'demo':
                 await runDemo();
-                break;
+                return;
             case 'version':
-                console.log(`\n${colors.cyan}cure${colors.reset} v${VERSION}`);
-                break;
+                console.log(`\n${colors.cyan}cure${colors.reset} v${VERSION} (${XAI_MODEL})`);
+                return;
+            case 'model':
+                console.log(`\n${colors.cyan}Model:${colors.reset} ${XAI_MODEL}`);
+                console.log(`${colors.cyan}API:${colors.reset} ${process.env.XAI_API_KEY ? 'Connected' : 'Not configured'}`);
+                return;
             default:
                 console.log(`\n${colors.red}Unknown command: /${cmd}${colors.reset}`);
                 console.log(`${colors.dim}Type /help for available commands.${colors.reset}`);
+                return;
         }
-        return;
-    }
-    // Natural language processing
-    if (lower.includes('analyze') && lower.includes('patient')) {
-        const match = input.match(/patient\s+(\w+)/i) || input.match(/P\d+/i);
-        const patientId = match ? match[0].replace(/patient\s+/i, '') : 'P001';
-        await analyzePatient(patientId, lower.includes('genom'));
-    }
-    else if (lower.includes('treatment') || lower.includes('plan')) {
-        const match = input.match(/patient\s+(\w+)/i) || input.match(/P\d+/i);
-        const patientId = match ? match[0].replace(/patient\s+/i, '') : 'P001';
-        await designTreatmentPlan(patientId);
-    }
-    else if (lower.includes('drug') || lower.includes('target') || lower.includes('discover')) {
-        const genes = ['EGFR', 'KRAS', 'BRAF', 'HER2', 'ALK', 'ROS1', 'PIK3CA', 'TP53'];
-        const cancers = ['lung', 'breast', 'colon', 'melanoma', 'pancreatic'];
-        let gene = 'EGFR';
-        let cancer = 'Lung';
-        for (const g of genes) {
-            if (lower.includes(g.toLowerCase())) {
-                gene = g;
-                break;
-            }
-        }
-        for (const c of cancers) {
-            if (lower.includes(c)) {
-                cancer = c.charAt(0).toUpperCase() + c.slice(1);
-                break;
-            }
-        }
-        await discoverTargets(gene, cancer);
-    }
-    else if (lower.includes('demo')) {
-        await runDemo();
-    }
-    else {
-        // Default response
-        console.log(`\n${colors.cyan}I can help you with:${colors.reset}`);
-        console.log(`  ${colors.dim}•${colors.reset} Analyzing patient data`);
-        console.log(`  ${colors.dim}•${colors.reset} Designing treatment plans`);
-        console.log(`  ${colors.dim}•${colors.reset} Discovering drug targets`);
-        console.log(`  ${colors.dim}•${colors.reset} Running clinical demos`);
-        console.log(`\n${colors.dim}Try: "analyze patient P001" or type /help${colors.reset}`);
     }
+    // AI-powered response for natural language
+    console.log(`\n${colors.dim}Thinking...${colors.reset}`);
+    const response = await callXAI(input);
+    console.log(`\n${response}`);
 }
 async function analyzePatient(patientId, includeGenomics = false) {
     console.log(`\n${colors.cyan}Analyzing patient ${patientId}...${colors.reset}\n`);
@@ -230,6 +293,7 @@ async function runDemo() {
     }
 }
 async function handleCommand(args) {
+    cancerTreatment = new CancerTreatmentCapabilityModule();
     if (args.includes('--analyze-patient')) {
         const patientId = args.find(a => a.startsWith('--patient='))?.split('=')[1] || 'P001';
         await analyzePatient(patientId, args.includes('--genomics'));
@@ -264,7 +328,7 @@ ${colors.cyan}${colors.bold}  ╔═══════════════
   ║   ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝                         ║
   ║                                                             ║
   ║   AI Cancer Treatment Framework                             ║
-  ║   Precision Oncology Research & Clinical Decision Support   ║
+  ║   Powered by xAI Grok ${XAI_MODEL}              ║
   ║                                                             ║
   ╚═══════════════════════════════════════════════════════════╝${colors.reset}
 
@@ -279,24 +343,28 @@ ${colors.dim}──────────────────────
   ${colors.cyan}/plan${colors.reset} [patient]        Design treatment plan
   ${colors.cyan}/discover${colors.reset} [gene]       Drug target discovery
   ${colors.cyan}/demo${colors.reset}                  Run framework demo
-  ${colors.cyan}/clear${colors.reset}                 Clear screen
+  ${colors.cyan}/model${colors.reset}                 Show AI model info
+  ${colors.cyan}/clear${colors.reset}                 Clear conversation
   ${colors.cyan}/help${colors.reset}                  Show this help
   ${colors.cyan}/exit${colors.reset}                  Exit
 
-${colors.bold}Natural Language${colors.reset}
+${colors.bold}AI Chat${colors.reset}
 ${colors.dim}─────────────────────────────${colors.reset}
-  "analyze patient P001"
-  "create treatment plan for P002"
-  "find EGFR targets in lung cancer"
-  "run demo"
+  Just type naturally to chat with the AI oncologist:
+
+  "What are the treatment options for EGFR+ lung cancer?"
+  "Explain pembrolizumab mechanism of action"
+  "What biomarkers predict response to immunotherapy?"
+  "Compare osimertinib vs erlotinib for EGFR mutations"
 `);
 }
 function printHelp() {
     console.log(`
 ${colors.bold}Cure - AI Cancer Treatment Framework${colors.reset}
+Powered by xAI ${XAI_MODEL}
 
 ${colors.bold}Usage:${colors.reset}
-  cure                    Launch interactive mode
+  cure                    Launch interactive AI chat
   cure [command]          Run a specific command
 
 ${colors.bold}Commands:${colors.reset}
@@ -314,10 +382,12 @@ ${colors.bold}Options:${colors.reset}
   --target=<gene>         Target gene (default: EGFR)
   --cancer=<type>         Cancer type (default: Lung)
 
+${colors.bold}Environment:${colors.reset}
+  XAI_API_KEY             xAI API key for AI-powered responses
+
 ${colors.bold}Examples:${colors.reset}
   cure
   cure --analyze-patient --patient=P001 --genomics
-  cure --treatment-plan --patient=P001
   cure --drug-discovery --target=BRAF --cancer=Melanoma
 
 ${colors.dim}https://npmjs.com/package/@erosolaraijs/cure${colors.reset}

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package/dist/clinician/index.d.ts

@@ -1,5 +1,5 @@
 /**
  * Clinician Decision Support Module Exports
  */
-export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator, type ClinicalRecommendation, type OverrideRecord, type TumorBoardCase, type RiskBenefitAnalysis, type RecommendationExplanation, type DecisionSupportConfig } from './decisionSupport.js';
+export { ClinicalDecisionSupportService, type ClinicalRecommendation, type ClinicianOverride, type OverrideCategory, type TumorBoardCase, type AlertAcknowledgment } from './decisionSupport.js';
 //# sourceMappingURL=index.d.ts.map

package/dist/clinician/index.d.ts.map

@@ -1 +1 @@
-{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,uBAAuB,EACvB,oBAAoB,EACpB,eAAe,EACf,iBAAiB,EACjB,mBAAmB,EACnB,oBAAoB,EACpB,KAAK,sBAAsB,EAC3B,KAAK,cAAc,EACnB,KAAK,cAAc,EACnB,KAAK,mBAAmB,EACxB,KAAK,yBAAyB,EAC9B,KAAK,qBAAqB,EAC3B,MAAM,sBAAsB,CAAC"}
+{"version":3,"file":"index.d.ts","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,8BAA8B,EAC9B,KAAK,sBAAsB,EAC3B,KAAK,iBAAiB,EACtB,KAAK,gBAAgB,EACrB,KAAK,cAAc,EACnB,KAAK,mBAAmB,EACzB,MAAM,sBAAsB,CAAC"}

package/dist/clinician/index.js

@@ -1,5 +1,5 @@
 /**
  * Clinician Decision Support Module Exports
  */
-export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator } from './decisionSupport.js';
+export { ClinicalDecisionSupportService } from './decisionSupport.js';
 //# sourceMappingURL=index.js.map

package/dist/clinician/index.js.map

@@ -1 +1 @@
-{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,uBAAuB,EACvB,oBAAoB,EACpB,eAAe,EACf,iBAAiB,EACjB,mBAAmB,EACnB,oBAAoB,EAOrB,MAAM,sBAAsB,CAAC"}
+{"version":3,"file":"index.js","sourceRoot":"","sources":["../../src/clinician/index.ts"],"names":[],"mappings":"AAAA;;GAEG;AACH,OAAO,EACL,8BAA8B,EAM/B,MAAM,sBAAsB,CAAC"}

package/dist/compliance/index.d.ts

@@ -1,5 +1,5 @@
 /**
  * HIPAA Compliance Module Exports
  */
-export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService, type AuditLogEntry, type PatientConsent, type ConsentScope, type AccessPolicy, type AccessDecision, type HIPAAConfig } from './hipaa.js';
+export { HIPAAComplianceService, type AuditLogEntry, type AuditEventType, type AuditAction, type PatientConsent, type ConsentType, type DataCategory, type ConsentPurpose, type AccessPolicy, type AccessCondition, type AccessDecision, type EncryptionConfig, type EncryptedData, type DataMaskingConfig } from './hipaa.js';
 //# sourceMappingURL=index.d.ts.map

package/dist/compliance/index.d.ts.map

@@ -1 +1 @@
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package/dist/compliance/index.js

@@ -1,5 +1,5 @@
 /**
  * HIPAA Compliance Module Exports
  */
-export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService } from './hipaa.js';
+export { HIPAAComplianceService } from './hipaa.js';
 //# sourceMappingURL=index.js.map

package/dist/compliance/index.js.map

@@ -1 +1 @@
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package/dist/index.d.ts

@@ -0,0 +1,65 @@
+/**
+ * AGI Core - Cure Cancer
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * Comprehensive AI-powered precision oncology platform connecting:
+ * - Real genomic sequencing data (Foundation Medicine, Guardant, Tempus)
+ * - Hospital EHR systems (Epic, Cerner via HL7 FHIR)
+ * - Clinical trial registries (ClinicalTrials.gov)
+ * - HIPAA-compliant data handling
+ * - ML-powered outcome prediction
+ * - Drug safety and interaction checking
+ * - Clinician decision support
+ * - Patient portal interfaces
+ *
+ * @packageDocumentation
+ */
+export { CancerTreatmentCapabilityModule, type CancerTreatmentOperationType, type CancerPatient, type CancerTreatmentOperation, type CancerTreatmentResult, type TreatmentProtocol, type DrugTarget, type ImmunotherapyProtocol, type CombinationTherapy, type CancerCureResult } from './capabilities/cancerTreatmentCapability.js';
+export { RealWorldOncologyService, createRealWorldOncologyService, type RealWorldConfig, type RealWorldPatient, type ComprehensiveTreatmentPlan, type TreatmentOutcome } from './orchestrator/index.js';
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary, CancerDiagnosis, CancerBiomarkers, TreatmentHistory, type FHIRConfig, type FHIRResource, type FHIRPatient, type FHIRObservation, type FHIRCondition, type FHIRMedicationRequest, type FHIRProcedure, type FHIRDiagnosticReport } from './integrations/ehr/index.js';
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService, type GenomicVariant, type CopyNumberAlteration, type GeneFusion, type GenomicReport, type TherapyMatch, type GenomicPlatformConfig } from './integrations/genomics/index.js';
+export { ClinicalTrialsGovClient, PatientTrialMatcher, type ClinicalTrial, type TrialLocation, type TrialEligibility, type PatientTrialMatch, type TrialSearchCriteria, type ClinicalTrialsConfig } from './integrations/clinicalTrials/index.js';
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService, type AuditLogEntry, type PatientConsent, type ConsentScope, type AccessPolicy, type AccessDecision, type HIPAAConfig } from './compliance/index.js';
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker, type PredictionInput, type ResponsePrediction, type SurvivalPrediction, type ToxicityPrediction, type ResistancePrediction, type TherapyRanking, type ModelMetadata, type MLConfig } from './ml/index.js';
+export { DrugSafetyService, DrugInteractionChecker, ContraindicationChecker, AllergyChecker, QTRiskAssessor, PharmacogenomicsChecker, BlackBoxWarningChecker, type DrugInteraction, type Contraindication, type AllergyAlert, type QTRiskAssessment, type PharmacogenomicAlert, type BlackBoxWarning, type SafetyCheckResult, type DrugSafetyConfig } from './safety/index.js';
+export { RetrospectiveValidator, CohortLoader, ConcordanceAnalyzer, PredictionAccuracyAnalyzer, SubgroupAnalyzer, ValidationReportGenerator, type ValidationCohort, type PatientOutcome, type ConcordanceResult, type PredictionAccuracy, type SubgroupAnalysis, type ValidationReport, type ValidationConfig } from './validation/index.js';
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator, type ClinicalRecommendation, type OverrideRecord, type TumorBoardCase, type RiskBenefitAnalysis, type RecommendationExplanation, type DecisionSupportConfig } from './clinician/index.js';
+export { PatientPortalService, PatientAccountManager, TreatmentSummaryService, SymptomTracker, MedicationAdherenceTracker, QualityOfLifeAssessment, SecureMessaging, EducationalContentService, AppointmentRequestService, PatientDashboard, type PatientAccount, type TreatmentSummary, type SymptomEntry, type AdherenceRecord, type QoLAssessment, type SecureMessage, type EducationalContent, type AppointmentRequest, type PatientDashboardData, type PatientPortalConfig } from './patient/index.js';
+/**
+ * Quick start factory to create a fully configured oncology service
+ *
+ * @example
+ * ```typescript
+ * import { createOncologyPlatform } from 'agi-core-cure-cancer';
+ *
+ * const platform = await createOncologyPlatform({
+ *   ehr: {
+ *     enabled: true,
+ *     vendor: 'epic',
+ *     baseUrl: 'https://epic.hospital.org/fhir',
+ *     clientId: 'your-client-id'
+ *   },
+ *   genomics: {
+ *     enabled: true,
+ *     platforms: ['foundation', 'guardant']
+ *   }
+ * });
+ *
+ * const plan = await platform.generateComprehensivePlan(patient, 'DR001');
+ * ```
+ */
+export declare function createOncologyPlatform(config?: Partial<import('./orchestrator/index.js').RealWorldConfig>): Promise<RealWorldOncologyService>;
+declare const _default: {
+    createOncologyPlatform: typeof createOncologyPlatform;
+    createRealWorldOncologyService: any;
+    CancerTreatmentCapabilityModule: any;
+    RealWorldOncologyService: any;
+};
+export default _default;
+//# sourceMappingURL=index.d.ts.map

package/dist/index.d.ts.map

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package/dist/index.js

@@ -0,0 +1,102 @@
+/**
+ * AGI Core - Cure Cancer
+ *
+ * ██████╗██╗   ██╗██████╗ ███████╗     ██████╗ █████╗ ███╗   ██╗ ██████╗███████╗██████╗
+ * ██╔════╝██║   ██║██╔══██╗██╔════╝    ██╔════╝██╔══██╗████╗  ██║██╔════╝██╔════╝██╔══██╗
+ * ██║     ██║   ██║██████╔╝█████╗      ██║     ███████║██╔██╗ ██║██║     █████╗  ██████╔╝
+ * ██║     ██║   ██║██╔══██╗██╔══╝      ██║     ██╔══██║██║╚██╗██║██║     ██╔══╝  ██╔══██╗
+ * ╚██████╗╚██████╔╝██║  ██║███████╗    ╚██████╗██║  ██║██║ ╚████║╚██████╗███████╗██║  ██║
+ *  ╚═════╝ ╚═════╝ ╚═╝  ╚═╝╚══════╝     ╚═════╝╚═╝  ╚═╝╚═╝  ╚═══╝ ╚═════╝╚══════╝╚═╝  ╚═╝
+ *
+ * Comprehensive AI-powered precision oncology platform connecting:
+ * - Real genomic sequencing data (Foundation Medicine, Guardant, Tempus)
+ * - Hospital EHR systems (Epic, Cerner via HL7 FHIR)
+ * - Clinical trial registries (ClinicalTrials.gov)
+ * - HIPAA-compliant data handling
+ * - ML-powered outcome prediction
+ * - Drug safety and interaction checking
+ * - Clinician decision support
+ * - Patient portal interfaces
+ *
+ * @packageDocumentation
+ */
+// ═══════════════════════════════════════════════════════════════════════════════
+// CORE CAPABILITIES
+// ═══════════════════════════════════════════════════════════════════════════════
+export { CancerTreatmentCapabilityModule } from './capabilities/cancerTreatmentCapability.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// REAL-WORLD ORCHESTRATION
+// ═══════════════════════════════════════════════════════════════════════════════
+export { RealWorldOncologyService, createRealWorldOncologyService } from './orchestrator/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// INTEGRATIONS
+// ═══════════════════════════════════════════════════════════════════════════════
+// EHR Integration (HL7 FHIR)
+export { FHIRClient, EpicAdapter, CernerAdapter, FHIRPatientSummary } from './integrations/ehr/index.js';
+// Genomic Platforms
+export { FoundationMedicineClient, GuardantHealthClient, TempusClient, UnifiedGenomicsService } from './integrations/genomics/index.js';
+// Clinical Trials
+export { ClinicalTrialsGovClient, PatientTrialMatcher } from './integrations/clinicalTrials/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// COMPLIANCE
+// ═══════════════════════════════════════════════════════════════════════════════
+export { HIPAAComplianceService, AuditLogger, ConsentManager, EncryptionService, AccessControlManager, DataMaskingService } from './compliance/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// MACHINE LEARNING
+// ═══════════════════════════════════════════════════════════════════════════════
+export { OutcomePredictionService, ResponsePredictor, SurvivalPredictor, ToxicityPredictor, ResistancePredictor, TherapyRanker } from './ml/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// SAFETY
+// ═══════════════════════════════════════════════════════════════════════════════
+export { DrugSafetyService, DrugInteractionChecker, ContraindicationChecker, AllergyChecker, QTRiskAssessor, PharmacogenomicsChecker, BlackBoxWarningChecker } from './safety/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// VALIDATION
+// ═══════════════════════════════════════════════════════════════════════════════
+export { RetrospectiveValidator, CohortLoader, ConcordanceAnalyzer, PredictionAccuracyAnalyzer, SubgroupAnalyzer, ValidationReportGenerator } from './validation/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// CLINICIAN SUPPORT
+// ═══════════════════════════════════════════════════════════════════════════════
+export { ClinicalDecisionSupport, RecommendationEngine, OverrideManager, TumorBoardManager, RiskBenefitAnalyzer, ExplanationGenerator } from './clinician/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// PATIENT PORTAL
+// ═══════════════════════════════════════════════════════════════════════════════
+export { PatientPortalService, PatientAccountManager, TreatmentSummaryService, SymptomTracker, MedicationAdherenceTracker, QualityOfLifeAssessment, SecureMessaging, EducationalContentService, AppointmentRequestService, PatientDashboard } from './patient/index.js';
+// ═══════════════════════════════════════════════════════════════════════════════
+// QUICK START FACTORY
+// ═══════════════════════════════════════════════════════════════════════════════
+/**
+ * Quick start factory to create a fully configured oncology service
+ *
+ * @example
+ * ```typescript
+ * import { createOncologyPlatform } from 'agi-core-cure-cancer';
+ *
+ * const platform = await createOncologyPlatform({
+ *   ehr: {
+ *     enabled: true,
+ *     vendor: 'epic',
+ *     baseUrl: 'https://epic.hospital.org/fhir',
+ *     clientId: 'your-client-id'
+ *   },
+ *   genomics: {
+ *     enabled: true,
+ *     platforms: ['foundation', 'guardant']
+ *   }
+ * });
+ *
+ * const plan = await platform.generateComprehensivePlan(patient, 'DR001');
+ * ```
+ */
+export async function createOncologyPlatform(config) {
+    const service = createRealWorldOncologyService(config);
+    await service.initialize();
+    return service;
+}
+// Default export
+export default {
+    createOncologyPlatform,
+    createRealWorldOncologyService,
+    CancerTreatmentCapabilityModule,
+    RealWorldOncologyService
+};
+//# sourceMappingURL=index.js.map

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