@datagrok/eda 1.4.12 → 1.5.0

package/dist/package-test.js

@@ -1,2 +1,2 @@
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Set([ct.HAMMING,ct.LEVENSTEIN,ct.NEEDLEMAN_WUNSCH,ct.MONOMER_CHEMICAL_DISTANCE,ct.OneHot]),new Set([ct.HAMMING,ct.EUCLIDEAN,ct.MANHATTAN,ct.MONOMER_CHEMICAL_DISTANCE,ct.LEVENSTEIN,ct.NEEDLEMAN_WUNSCH,ct.TANIMOTO,ct.COSINE,ct.VECTOR_COSINE,ct.SOKAL,ct.ASYMMETRIC,ct.OneHot,ct.Difference]),new Set([ct.EUCLIDEAN,ct.MANHATTAN,ct.OneHot,ct.Difference,ct.VECTOR_COSINE]),new Set([ct.EUCLIDEAN,ct.MANHATTAN,ct.Difference,ct.VECTOR_COSINE]),new Set([ct.EUCLIDEAN,ct.MANHATTAN,ct.Difference]),new Set([ct.TANIMOTO,ct.COSINE,ct.SOKAL,ct.ASYMMETRIC]),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(ft||(ft={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(ht||(ht={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(mt||(mt={})),Object.prototype.toString;const dt="dimensionality-reducer-terminate-event";var pt,gt;(gt=pt||(pt={})).EUCLIDEAN="EUCLIDEAN",gt.MANHATTAN="MANHATTAN";const yt=t=>null==t;function vt(t,n){return`${n} (${t.length>4?`${t.length} columns`:t.map(t=>t.name).join(", ")})`}async function wt(r,o,i,s,a,u,c,l=!0,f=!1,h={preprocessingFuncArgs:[]},m={},d=null,p={},g){const y={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(o.length!==s.length||o.length!==u.length||o.length!==a.length||o.length!==h.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=l?m.tableView??n.shell.tableView(r.name)??n.shell.addTableView(r):null,w=async()=>{const w=t.TaskBarProgressIndicator.create(`Initializing ${m.scatterPlotName??"dimensionality reduction"} ...`);let E;try{const A=function(t){const n=["Embed_X","Embed_Y"],e=t.columns.names().filter(t=>t.includes(n[0])).length+1;return n.map(t=>`${t}_${e}`)}(r);function C(n,e,s){let a=null,u=null;r.columns.names().includes(A[0])?(a=r.columns.byName(A[0]),u=r.columns.byName(A[1])):(a=r.columns.add(t.Column.float(A[0],r.rowCount)),u=r.columns.add(t.Column.float(A[1],r.rowCount)),l&&!E&&(E=v.scatterPlot({...y,x:A[0],y:A[1],title:m.scatterPlotName??vt(o,i)}))),m["show-scatterplot-progress"]&&(E?.root&&it.setUpdateIndicator(E.root,!1),a.init(t=>s[0]?s[0][t]:void 0),u.init(t=>s[1]?s[1][t]:void 0));const c=n/e*100;w.update(c,`Running ${m.scatterPlotName??"dimensionality reduction"}... ${c.toFixed(0)}%`)}async function _(){r.columns.add(t.Column.float(A[0],r.rowCount)),r.columns.add(t.Column.float(A[1],r.rowCount));let f=null;l&&(E=v.scatterPlot({...y,x:A[0],y:A[1],title:m.scatterPlotName??vt(o,i)}),it.setUpdateIndicator(E.root,!0));const d=n.events.onViewerClosed.subscribe(t=>{const e=t.args.viewer;e?.getOptions()?.look?.title&&E?.getOptions()?.look?.title&&e?.getOptions()?.look?.title===E?.getOptions()?.look?.title&&(n.events.fireCustomEvent(dt,{}),d.unsubscribe(),f?.(),w.close())}),p=new Promise(async(t,l)=>{try{f=t;const l=[];let d=s,p=a,y=c;if(g&&o.every(t=>t.isNumerical)){const t=o.map(t=>t.toList()),n=new Array(r.rowCount).fill(0).map((t,n)=>new Float32Array(o.length));for(let e=0;e<o.length;++e)for(let o=0;o<r.rowCount;++o)n[o][e]=t[e][o];h.distanceFnArgs=[{}],l.push({entries:n,options:{}}),d=[g],p=[1],y="MANHATTAN"}else for(let t=0;t<u.length;++t){const n=u[t];if(h.distanceFnArgs||(h.distanceFnArgs=[]),n){const e=n.inputs[0].name,r=n.inputs[1].name,{entries:i,options:a}=await n.apply({[e]:o[t],[r]:s[t],...h.preprocessingFuncArgs[t]??{}});l.push({entries:i,options:a}),h.distanceFnArgs.push(a)}else{const n=o[t].toList(),e={};l.push({entries:n,options:e}),h.distanceFnArgs.push(e)}}t(await async function(t,r,o,i,s,a,u){let c=await async function(t,r,o,i,s,a,u){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==r.length||t.length!==a.distanceFnArgs.length||t.length!==i.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,l){const f=new Worker(new URL(e.p+e.u(234),e.b));f.postMessage({columnsData:t,distanceMetrics:r,method:o,options:a,weights:i,aggregationMethod:s});const h=n.events.onCustomEvent(dt).subscribe(()=>{try{f?.terminate()}finally{h.unsubscribe()}});f.onmessage=({data:{error:t,embedding:n,epochNum:e,epochsLength:r}})=>{yt(e)||yt(r)?(h.unsubscribe(),t?l(t):c(n),setTimeout(()=>f.terminate(),100)):u&&u(e,r,n)}})}(t,o,r,i,s,a,u);return c=c.map(t=>function(t){const n=t.length;let e=0,r=0;for(let o=0;o<n;++o)e+=t[o],r+=Math.pow(t[o],2);const o=e/n,i=1/Math.sqrt(r/n-Math.pow(o,2));for(let e=0;e<n;++e)t[e]=(t[e]-o)*i;return t}(t)),c}(l.map(t=>t.entries),i,d,p,c,h,m[st]?void 0:C))}catch(t){l(t)}}),_=await p;return w.close(),d.unsubscribe(),_}const N=await _();if(f&&N){const x=t.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const b=await function(t,n,r,o){return i=this,s=void 0,u=function*(){return new Promise(function(i,s){const a=new Worker(new URL(e.p+e.u(682),e.b));a.postMessage({embedX:t,embedY:n,minPts:o,epsilon:r}),a.onmessage=({data:{error:t,clusters:n}})=>{a.terminate(),t?s(t):i(n)}})},new((a=void 0)||(a=Promise))(function(t,n){function e(t){try{o(u.next(t))}catch(t){n(t)}}function r(t){try{o(u.throw(t))}catch(t){n(t)}}function o(n){var o;n.done?t(n.value):(o=n.value,o instanceof a?o:new a(function(t){t(o)})).then(e,r)}o((u=u.apply(i,s||[])).next())});var i,s,a,u}(N[0],N[1],h.dbScanEpsilon??.01,h.dbScanMinPts??4),S=r.columns.getUnusedName("Cluster (DBSCAN)");r.columns.addNewString(S).init(t=>b[t].toString()),E&&(E.props.colorColumnName=S)}catch(T){n.shell.error("Clustering embeddings failed"),console.error(T)}finally{x.close()}}if(N){const I=r.columns.byName(A[0]),M=r.columns.byName(A[1]);if(I.init(t=>N[0][t]),M.init(t=>N[1][t]),d)try{const O=d.inputs[0].name,R=d.inputs[1].name;await d.prepare({[O]:I,[R]:M,...p}).call(!0)}catch(L){n.shell.error("Post-processing failed"),console.error(L)}if(E)return it.setUpdateIndicator(E.root,!1),E.helpUrl="/help/compute/sequence-space",E}}catch(P){n.shell.error("Dimensionality reduction failed"),console.error(P),w.close(),E&&it.setUpdateIndicator(E.root,!1)}};return new Promise(async(t,n)=>{try{if(m.fastRowCount&&r.rowCount>m.fastRowCount&&!m[st])it.dialog().add(it.divText("Analysis might take several minutes. 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St{constructor(t){this.data=t}complementArrOfParams(t){t.push(this.data)}complementArrOfTypes(t){t.push("number")}allocateMemoryForBuffer(t){}isMemoryForBufferAllocated(){return!0}putDataToBuffer(t){}getDataFromBuffer(t){}freeBuffer(t){}}class Tt extends St{constructor(t,n,e=!1){super(t),this.type=n,this.toUpdate=e,this.buf=0,this.numOfRows=t.length}complementArrOfParams(t){t.push(this.buf),t.push(this.numOfRows)}complementArrOfTypes(t){t.push("number"),t.push("number")}allocateMemoryForBuffer(t){this.buf=t._malloc(this.numOfRows*Nt[this.type].BYTES_PER_ELEMENT)}isMemoryForBufferAllocated(){return 0!=this.buf}putDataToBuffer(t){if(this.isMemoryForBufferAllocated()){const n=this.type,e=xt[n],r=t[_t[n]];let o=null;const i=this.data;o="int"==i.type&&"i32"==n||"double"==i.type&&"f32"==n?i.getRawData():new Nt[n](i.getRawData()),o&&r.set(o,this.buf>>e)}}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const n=this.type,e=t[_t[n]],r=this.buf,o=Nt[n].BYTES_PER_ELEMENT,i=this.data.getRawData();for(let t=0;t<this.numOfRows;t++)i[t]=e[r/o+t]}}freeBuffer(t){this.isMemoryForBufferAllocated()&&(t._free(this.buf),this.buf=0)}}class It extends Tt{constructor(t,n){super([],t,!0),this.numOfRows=n}putDataToBuffer(t){}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const n=this.type,e=t[_t[n]],r=this.buf,o=bt[n],i=new Nt[n](this.numOfRows);for(let t=0;t<i.length;t++)i[t]=e[r/i.BYTES_PER_ELEMENT+t];this.data=o("name",i)}}}class Mt extends St{constructor(t,n,e=!1){super(t),this.type=n,this.toUpdate=e,this.buf=0,this.numOfColumns=t.length,this.numOfRows=t[0].length}complementArrOfParams(t){t.push(this.buf),t.push(this.numOfRows),t.push(this.numOfColumns)}complementArrOfTypes(t){t.push("number"),t.push("number"),t.push("number")}allocateMemoryForBuffer(t){this.buf=t._malloc(this.numOfRows*this.numOfColumns*Nt[this.type].BYTES_PER_ELEMENT)}isMemoryForBufferAllocated(){return 0!=this.buf}putDataToBuffer(t){if(this.isMemoryForBufferAllocated()){const n=this.type,e=xt[n],r=t[_t[n]],o=Nt[n].BYTES_PER_ELEMENT;for(let t=0;t<this.numOfColumns;t++){let i=null;const s=this.data[t];i="int"==s.type&&"i32"==n||"double"==s.type&&"f32"==n?s.getRawData():new Nt[n](s.getRawData()),null!=i&&r.set(i,this.buf+t*this.numOfRows*o>>e)}}}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const n=this.type,e=t[_t[n]],r=this.numOfRows,o=this.numOfColumns,i=new Nt[n](e.buffer,this.buf,r*o);for(let t=0;t<o;t++){const n=this.data[t].getRawData();for(let e=0;e<r;e++)n[e]=i[e+t*r]}}}freeBuffer(t){this.isMemoryForBufferAllocated()&&(t._free(this.buf),this.buf=0)}}class Ot extends Mt{constructor(t,n,e){super([[]],t,!0),this.data=[],this.numOfColumns=e,this.numOfRows=n}putDataToBuffer(t){}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const n=this.type,e=t[_t[n]],r=this.numOfRows,o=this.numOfColumns,i=Nt[n].BYTES_PER_ELEMENT,s=bt[n],a=this.buf;for(let t=0;t<o;t++){const o=new Nt[n](r);for(let n=0;n<r;n++)o[n]=e[a/i+n+t*r];this.data.push(s((t+1).toString(),o))}}}}const Rt={intColumn:t=>new Tt(t,"i32"),newIntColumn:t=>new It("i32",t),intColumns:t=>new Mt(t.toList(),"i32"),newIntColumns:(t,n)=>new Ot("i32",t,n),floatColumn:t=>new Tt(t,"f32"),newFloatColumn:t=>new It("f32",t),floatColumns:t=>new Mt(t.toList(),"f32"),newFloatColumns:(t,n)=>new Ot("f32",t,n),int:t=>new St(t),num:t=>new St(t)},Lt={tableFromColumns:t=>DG.DataFrame.fromColumns(t.data),num:t=>t,int:t=>t,double:t=>t,column:t=>t.data};function Pt(t,n,e){const r=t[n],o=r.arguments,i=[];let s=0;for(const t in o){const n=o[t];if("_callResult"!=t){switch(n.type){case"floatColumns":case"int":case"num":case"floatColumn":case"intColumn":case"intColumns":n.data=Rt[n.type](e[s]),s++;break;case"newFloatColumns":case"newIntColumns":const t=o[n.numOfRows.ref].data[n.numOfRows.value],r=o[n.numOfColumns.ref].data[n.numOfColumns.value];n.data=Rt[n.type](t,r);break;case"newFloatColumn":case"newIntColumn":const i=o[n.numOfRows.ref].data[n.numOfRows.value];n.data=Rt[n.type](i)}i.push(o[t].data)}}const a=function(t,n,e,r){let o;for(const n of r)n.allocateMemoryForBuffer(t);let i=!0;for(const t of r)i&=t.isMemoryForBufferAllocated();if(i){const e=[],i=[];for(const n of r)n.complementArrOfParams(e),n.complementArrOfTypes(i),n.putDataToBuffer(t);const s="number";o=t.ccall(n,s,i,e);for(const n of r)n.getDataFromBuffer(t)}for(const n of r)n.freeBuffer(t);if(null!=o)return o}(t,n,0,i);o._callResult=Rt.num(a);const u=r.output;if("objects"!=u.type)return Lt[u.type](o[u.source].data);const c=[];for(const t of u.source)c.push(o[t].data.data);return c}const Dt="num",Ft="floatColumn",Ut="intColumn",Bt="floatColumns",kt="newFloatColumns",Ht="intColumns",Gt="newIntColumns",Vt="newFloatColumn",qt="newIntColumn",Wt="numOfRows",$t="numOfColumns",Yt="ref",Kt="value",jt="int",zt="double",Xt={intColumn:Int32Array,floatColumn:Float32Array,floatColumns:Float32Array,newFloatColumns:Float32Array,intColumns:Int32Array,newIntColumns:Int32Array,newFloatColumn:Float32Array,newIntColumn:Int32Array};function Qt(t,n){let e,r=[],o=0;for(const i in t){const s=t[i],a=s.type;if("_callResult"!==i){switch(a){case Dt:case jt:case zt:s.data=n[o],o++;break;case Ut:case Ft:let r;const i=n[o],u=i.length;r=i.type===jt&&a===Ut||i.type===zt&&a===Ft?i.getRawData().slice(0,u):new Xt[a](i.getRawData().slice(0,u)),s.data={array:r,numOfRows:u},o++;break;case qt:case Vt:let c=0;e=s[Wt][Yt],c=t[e].type===Dt?t[e].data:t[e].data[s[Wt][Kt]],s.data={numOfRows:c},o++;break;case Ht:case Bt:let l=[];const f=n[o].byIndex(0).length;for(const t of 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model",(gn=ln||(ln={})).PLS="/help/explore/multivariate-analysis#pls-components",gn.MVA="/help/explore/multivariate-analysis",gn.MODEL="/help/explore/multivariate-analysis#observed-vs-predicted",gn.COEFFS="/help/explore/multivariate-analysis#regression-coefficients",gn.LOADINGS="/help/explore/multivariate-analysis#loadings",gn.EXPL_VARS="/help/explore/multivariate-analysis#explained-variance",gn.SCORES="/help/explore/multivariate-analysis#scores",(pn=fn||(fn={}))[pn.DEFAULT=3]="DEFAULT",pn[pn.MIN=1]="MIN",(dn=hn||(hn={})).PREFIX="PLS",dn.SUFFIX="(predicted)",dn.COMP="component",dn.COMPS="components",function(t){t[t.PREDICTION=0]="PREDICTION",t[t.REGR_COEFFS=1]="REGR_COEFFS",t[t.T_SCORES=2]="T_SCORES",t[t.U_SCORES=3]="U_SCORES",t[t.X_LOADINGS=4]="X_LOADINGS",t[t.Y_LOADINGS=5]="Y_LOADINGS"}(mn||(mn={}));const Cn=[.49,.79,.99];var _n,Nn;(Nn=_n||(_n={})).AXIS="#838383",Nn.CIRCLE="#0000FF",Nn.INVALID="#EB6767",Nn.VALID_TEXT="#4d5261",Nn.VALID_LINE="#dbdcdf",[{caption:un.MODEL,text:"Closer 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s=this.getRegrCoeffs(n,e,o.regressionCoefficients),a=this.getLoadings(r,o.xLoadings);this.specn={names:i,params:s,loadings:a,components:r,dim:n.length,scores:this.getScoresDf(o)},this.computeExplVars(e.length,r,o.yLoadings)},new((s=void 0)||(s=Promise))(function(t,n){function e(t){try{u(a.next(t))}catch(t){n(t)}}function r(t){try{u(a.throw(t))}catch(t){n(t)}}function u(n){var o;n.done?t(n.value):(o=n.value,o instanceof s?o:new s(function(t){t(o)})).then(e,r)}u((a=a.apply(o,i||[])).next())});var o,i,s,a}getLoadings(t,n){const e=Array(t),r=n[0].length+1;for(let o=0;o<t;++o)e[o]=new Float32Array(r),e[o].set(n[o].getRawData());return e}getRegrCoeffs(t,n,e){const r=t.length,o=new Float32Array(r+1),i=e.getRawData();let s=0;for(let n=0;n<r;++n)o[n]=i[n],s+=i[n]*t.byIndex(n).stats.avg;return o[r]=n.stats.avg-s,o}computeExplVars(t,n,e){if(null===this.specn)throw new Error("Failed to compute explained variances");const r=e.getRawData(),o=this.specn.loadings[0].length-1;let i=Math.pow(r[0],2)/t;this.specn.loadings[0][o]=i;for(let e=1;e<n;++e)i+=Math.pow(r[e],2)/t,this.specn.loadings[e][o]=i}toBytes(){if(null===this.specn)throw new Error("Failed to pack untrained model");const n=t.DataFrame.fromColumns([t.Column.fromStrings(un.FEATURES,this.specn.names),t.Column.fromFloat32Array(un.REGR_COEFS,this.specn.params)]);this.specn.loadings.forEach((e,r)=>n.columns.add(t.Column.fromFloat32Array(`${un.XLOADING}${r+1}`,e)));const e=n.toByteArray(),r=e.length,o=this.specn.scores.toByteArray(),i=o.length,s=r+i+8,a=new Uint8Array(64*(Math.ceil(s/64)+1)),u=new Uint32Array(a.buffer,0,2);return u[0]=r,u[1]=i,a.set(e,8),a.set(o,8+r),a}predict(t){if(null===this.specn)throw new Error("Predicting failed: model is not trained");return Tn(t,this.specn.params)}loadingsParamsViewers(){if(null===this.specn)throw new Error("Failed to create loadings and parameters viewers: untrained model");const n=[],e=this.specn.dim,r=t.DataFrame.fromColumns([t.Column.fromStrings(un.FEATURES,this.specn.names.slice(0,-1)),t.Column.fromFloat32Array(un.REGR_COEFS,this.specn.params,e)]),o=r.columns,i=o.length,s=this.specn.components;return this.specn.loadings.forEach((n,o)=>r.columns.add(t.Column.fromFloat32Array(`${un.XLOADING}${o+1}`,n,e))),n.push(t.Viewer.scatterPlot(r,{title:un.LOADINGS,xColumnName:o.byIndex(i).name,yColumnName:o.byIndex(i+(s>1?1:0)).name,markerType:t.MARKER_TYPE.CIRCLE,labelFormColumnNames:[un.FEATURES],help:ln.LOADINGS})),n.push(t.Viewer.barChart(r,{title:un.REGR_COEFS,splitColumnName:un.FEATURES,valueColumnName:un.REGR_COEFS,valueAggrType:t.AGG.AVG,help:ln.COEFFS,showValueSelector:!1,showStackSelector:!1})),n}explVarsViewer(){if(null===this.specn)throw new Error("Failed to create exaplained variances viewer: untrained model");const n=this.specn.components,e=this.specn.dim,r=new Array(n),o=new Float32Array(n);r[0]=`${hn.COMP} 1`,o[0]=this.specn.loadings[0][e];for(let t=1;t<n;++t)r[t]=`${hn.COMPS} ${t+1}`,o[t]=this.specn.loadings[t][e];return t.Viewer.barChart(t.DataFrame.fromColumns([t.Column.fromStrings(hn.COMPS,r),t.Column.fromFloat32Array(un.EXPL_VAR,o)]),{title:un.EXPL_VAR,splitColumnName:hn.COMPS,valueColumnName:un.EXPL_VAR,valueAggrType:t.AGG.AVG,help:ln.EXPL_VARS,showCategorySelector:!1,showStackSelector:!1,showValueSelector:!1})}viewers(){if(null===this.specn)throw new Error("Failed to create viewers: untrained model");const t=this.loadingsParamsViewers();return t.push(this.explVarsViewer(),this.getScoresScatter()),t}getScoresDf(n){const e=n.tScores,r=n.uScores;return e.forEach((t,n)=>t.name=`${un.XSCORE}${n+1}`),r.forEach((t,n)=>t.name=`${un.YSCORE}${n+1}`),t.DataFrame.fromColumns(e.concat(r))}getScoresScatter(){if(null===this.specn)throw new Error("Failed to create scores scatter: untrained model");const 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0,function*(){const t=Pn(1e5,kn,1).columns,n=t.byIndex(kn),e=yield Sn(t,n),r=new Uint8Array(e.buffer);Tn(t,new Float32Array(r.buffer))}),{timeout:Hn,benchmark:!0}),O("Correctness",()=>Bn(void 0,void 0,void 0,function*(){const t=Pn(100,2,1).columns,n=t.byIndex(2),e=yield Sn(t,n),r=new Uint8Array(e.buffer),o=Tn(t,new Float32Array(r.buffer)),i=Dn(o,o);R(i<Gn,!0,`Incorrect linear regression computations, error is too big: ${i}; expected: < 0.1`)}),{timeout:Hn})});var Vn=function(t,n,e,r){return new(e||(e=Promise))(function(o,i){function s(t){try{u(r.next(t))}catch(t){i(t)}}function a(t){try{u(r.throw(t))}catch(t){i(t)}}function u(t){var n;t.done?o(t.value):(n=t.value,n instanceof e?n:new e(function(t){t(n)})).then(s,a)}u((r=r.apply(t,n||[])).next())})};const qn="Avg-s",Wn="Stddev-s";var $n;!function(t){t[t.MAX_SAMLPES=5e4]="MAX_SAMLPES",t[t.MAX_FEATURES=100]="MAX_FEATURES"}($n||($n={}));class Yn{static isApplicable(n,e){for(const t of n)if(!t.matches("numerical"))return!1;return e.type===t.COLUMN_TYPE.STRING}static isInteractive(t,n){return t.length<=$n.MAX_FEATURES&&n.length<=$n.MAX_SAMLPES}constructor(n,e){if(this.params=void 0,this.classesCount=1,this.featuresCount=1,void 0!==n){const t=n.featuresCount,e=n.classesCount;if(t<1)throw new Error("Incorrect features count");if(e<1)throw new Error("Incorrect classes count");const r=t+1;this.avgs=new Float32Array(r),this.stdevs=new Float32Array(r),this.categories=new Array(r),this.featuresCount=t,this.classesCount=e}else{if(void 0===e)throw new Error("Softmax classifier not initialized");try{const n=new Uint32Array(e.buffer,0,1)[0],r=new Uint8Array(e.buffer,4,n),o=t.DataFrame.fromByteArray(r),i=o.columns,s=i.length;if(s<3)throw new Error("incorrect columns count");this.classesCount=s-2,this.featuresCount=o.rowCount-1;const a=this.classesCount;this.params=new Array(a),this.categories=new Array(o.rowCount);for(let n=0;n<a;++n){const e=i.byIndex(n);if(this.categories[n]=e.name,e.type!==t.COLUMN_TYPE.FLOAT)throw new 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Error("Training failes - incorrect features count");if(r<=0||o<1||i<=0||s<=0)throw new Error("Training failes - incorrect fitting hyperparameters");this.extractStats(n);const a=e.length,u=e.categories.length,c=e.categories;for(let t=0;t<u;++t)this.categories[t]=c[t];try{const c=function(t,n,e,r,o,i,s,a,u,c,l){return Pt(EDA,"fitSoftmax",[t,n,e,r,o,i,s,a,u,c,l])}(n,t.Column.fromFloat32Array("avgs",this.avgs,this.featuresCount),t.Column.fromFloat32Array("stdevs",this.stdevs,this.featuresCount),t.Column.fromInt32Array("targets",e.getRawData(),a),u,o,r,i,s,this.featuresCount+1,u).columns;this.params=new Array(u);for(let t=0;t<u;++t)this.params[t]=c.byIndex(t).getRawData()}catch(t){try{this.params=yield this.fitSoftmaxParams(n,e,o,r,i,s)}catch(t){throw new Error("Training failes")}}if(void 0===this.params)throw new Error("Training failes")})}extractStats(n){let e=0;for(const r of n){if(r.type!==t.COLUMN_TYPE.INT&&r.type!==t.COLUMN_TYPE.FLOAT)throw new Error("Training failes - incorrect features type");this.avgs[e]=r.stats.avg,this.stdevs[e]=r.stats.stdev,++e}}normalized(n){const e=n.byIndex(0).length,r=new Array(e);for(let t=0;t<e;++t)r[t]=new Float32Array(this.featuresCount);let o=0;for(const i of n){if(i.type!==t.COLUMN_TYPE.INT&&i.type!==t.COLUMN_TYPE.FLOAT)throw new Error("Training failes - incorrect features type");const n=i.getRawData(),s=this.avgs[o],a=this.stdevs[o];if(a>0)for(let t=0;t<e;++t)r[t][o]=(n[t]-s)/a;else for(let t=0;t<e;++t)r[t][o]=0;++o}return r}transposed(n){const e=n.byIndex(0).length,r=this.featuresCount,o=new Array(r);for(let t=0;t<r;++t)o[t]=new Float32Array(e);let i=0;for(const r of n){if(r.type!==t.COLUMN_TYPE.INT&&r.type!==t.COLUMN_TYPE.FLOAT)throw new Error("Training failes - incorrect features type");const n=r.getRawData(),s=this.avgs[i],a=this.stdevs[i];if(a>0)for(let t=0;t<e;++t)o[i][t]=(n[t]-s)/a;else for(let t=0;t<e;++t)o[i][t]=0;++i}return o}preprocessedTargets(n){if(n.type!==t.COLUMN_TYPE.STRING)throw new Error("Training failes - incorrect target type");const e=this.classesCount,r=n.length,o=n.getRawData(),i=new Array(r),s=new Uint32Array(e).fill(0);for(let t=0;t<r;++t)i[t]=new Uint8Array(e).fill(0);for(let t=0;t<r;++t)i[t][o[t]]=1,++s[o[t]];return{oneHot:i,weights:s}}predict(n){if(void 0===this.params)throw new Error("Non-trained model");if(n.length!==this.featuresCount)throw new Error("Predcition fails: incorrect features count");const e=this.normalized(n),r=e.length,o=this.featuresCount,i=this.classesCount;let s,a;const u=new Float32Array(i);let c,l,f;const h=new Array(r);for(let t=0;t<r;++t){s=e[t],c=0;for(let t=0;t<i;++t){a=this.params[t],c=a[o];for(let t=0;t<o;++t)c+=a[t]*s[t];u[t]=Math.exp(c)}l=u[0],f=0;for(let t=1;t<i;++t)l<u[t]&&(l=u[t],f=t);h[t]=this.categories[f]}return t.Column.fromStrings("predicted",h)}fitSoftmaxParams(t,n,r,o,i,s){return Vn(this,void 0,void 0,function*(){const a=this.preprocessedTargets(n);return new Promise((u,c)=>{const l=new Worker(new URL(e.p+e.u(501),e.b));l.postMessage({features:this.normalized(t),transposed:this.transposed(t),oneHot:a.oneHot,classesWeights:a.weights,targetRaw:n.getRawData(),iterations:r,rate:o,penalty:i,tolerance:s}),l.onmessage=function(t){l.terminate(),u(t.data.params),console.log(`Loss: ${t.data.loss}`)}})})}}var Kn,jn,zn,Xn;(Xn=Kn||(Kn={}))[Xn.ITERATIONS=20]="ITERATIONS",Xn[Xn.ETA=.3]="ETA",Xn[Xn.MAX_DEPTH=6]="MAX_DEPTH",Xn[Xn.LAMBDA=1]="LAMBDA",Xn[Xn.ALPHA=0]="ALPHA",function(t){t[t.SAMLPES_HIGH=1e5]="SAMLPES_HIGH",t[t.SAMLPES_MID=5e4]="SAMLPES_MID",t[t.SAMPLES_LOW=1e4]="SAMPLES_LOW",t[t.FEATURES_HIGH=10]="FEATURES_HIGH",t[t.FEATURES_MID=20]="FEATURES_MID",t[t.FEATURES_LOW=100]="FEATURES_LOW"}(jn||(jn={})),function(t){t[t.MODEL=1e7]="MODEL",t[t.UTILS=1]="UTILS",t[t.PACK=128]="PACK",t[t.SIZE=4]="SIZE"}(zn||(zn={}));const Qn=t.FLOAT_NULL;var Zn;!function(t){t.PREDICT="Prediction",t.TYPE="Type",t.PARAMS="Params count",t.CATS="Categories",t.CATS_SIZE="Categories size"}(Zn||(Zn={}));class Jn{static isApplicable(t,n){for(const n of t)if(!n.matches("numerical"))return!1;return!(!n.matches("numerical")&&!n.matches("string"))}static isInteractive(t,n){const e=t.length,r=n.length;return r<=jn.SAMPLES_LOW?e<=jn.FEATURES_LOW:r<=jn.SAMLPES_MID?e<=jn.FEATURES_MID:r<=jn.SAMLPES_HIGH&&e<=jn.FEATURES_HIGH}constructor(n){var e;if(this.modelParams=void 0,this.targetType=void 0,this.targetCategories=void 0,n)try{let r=0;const o=new Uint32Array(n.buffer,r,1)[0];r+=zn.SIZE;const i=t.DataFrame.fromByteArray(new Uint8Array(n.buffer,r,o));r+=o,this.targetType=i.get(Zn.TYPE,0);const s=i.get(Zn.PARAMS,0),a=i.get(Zn.CATS_SIZE,0);if(a>0){const o=t.DataFrame.fromByteArray(new Uint8Array(n.buffer,r,a));this.targetCategories=null===(e=o.col(Zn.CATS))||void 0===e?void 0:e.toList()}r+=a,r=4*Math.ceil(r/4),this.modelParams=new Int32Array(n.buffer,r,s)}catch(t){throw new Error(`Failed to load model: ${t instanceof Error?t.message:"the platform issue"}`)}}fit(n,r){return o=this,i=arguments,a=function*(n,r,o=Kn.ITERATIONS,i=Kn.ETA,s=Kn.MAX_DEPTH,a=Kn.LAMBDA,u=Kn.ALPHA){this.targetType=r.type,this.targetType===t.COLUMN_TYPE.STRING&&(this.targetCategories=r.categories),this.modelParams=yield async function(t,n,r,o,i,s,a,u,c,l){return new Promise((f,h)=>{const m=n.length,d=t.length,p=new Float32Array(m*d);let g,y;for(let n=0;n<d;++n){y=t.byIndex(n).getRawData(),g=n*m;for(let t=0;t<m;++t)p[t+g]=y[t]}const v=new Worker(new URL(e.p+e.u(990),e.b));v.postMessage({features:p,target:n.getRawData(),samplesCount:m,featuresCount:d,modelReserve:c,utilsLength:l,iterations:o,eta:i,maxDepth:s,lambda:a,alpha:u,missingValue:r}),v.onmessage=function(t){v.terminate(),f(t.data.params)}})}(n,r,Qn,o,i,s,a,u,zn.MODEL,zn.UTILS)},new((s=void 0)||(s=Promise))(function(t,n){function e(t){try{u(a.next(t))}catch(t){n(t)}}function r(t){try{u(a.throw(t))}catch(t){n(t)}}function u(n){var o;n.done?t(n.value):(o=n.value,o instanceof s?o:new s(function(t){t(o)})).then(e,r)}u((a=a.apply(o,i||[])).next())});var o,i,s,a}predict(n){if(void 0===this.modelParams)throw new Error("Failed to apply non-trained model");const e=function(t,n,e){const r=t.byIndex(0).length,o=t.length,i=e.length;let s=XGBoostModule.HEAPF32;const a=XGBoostModule.HEAP32,u=XGBoostModule._malloc(r*o*4),c=XGBoostModule._malloc(4*r),l=XGBoostModule._malloc(4*i);for(let n=0;n<o;++n){const e=t.byIndex(n).getRawData();for(let t=0;t<r;++t)s[u/4+t+n*r]=e[t]}for(let t=0;t<i;++t)a[l/4+t]=e[t];XGBoostModule._predict(u,r,o,n,l,i,c,r),s=XGBoostModule.HEAPF32;const f=new Float32Array(r);for(let t=0;t<r;++t)f[t]=s[c/4+t];return XGBoostModule._free(u),XGBoostModule._free(c),XGBoostModule._free(l),f}(n,Qn,this.modelParams);switch(this.targetType){case t.COLUMN_TYPE.STRING:return this.stringColPrediction(e);case t.COLUMN_TYPE.INT:return this.intColPrediction(e);case t.COLUMN_TYPE.BIG_INT:return this.bigIntColPrediction(e);default:return t.Column.fromFloat32Array(Zn.PREDICT,e)}}toBytes(){if(void 0===this.modelParams||void 0===this.targetType)throw new Error("Failed to pack non-trained model");const n=void 0!==this.targetCategories?t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.STRING,Zn.CATS,this.targetCategories)]).toByteArray():void 0,e=void 0!==n?n.length:0,r=this.modelParams.length*this.modelParams.BYTES_PER_ELEMENT,o=t.DataFrame.fromColumns([t.Column.fromStrings(Zn.TYPE,[this.targetType]),t.Column.fromInt32Array(Zn.PARAMS,new Int32Array([this.modelParams.length])),t.Column.fromInt32Array(Zn.CATS_SIZE,new Int32Array([e]))]).toByteArray(),i=o.length,s=64*Math.ceil((zn.SIZE+i+e+r+zn.PACK)/64),a=new Uint8Array(s);let u=0;return new Uint32Array(a.buffer,u,1)[0]=i,u+=zn.SIZE,a.set(o,u),u+=i,e>0&&a.set(n,u),u+=e,u=4*Math.ceil(u/4),a.set(new Uint8Array(this.modelParams.buffer),u),a}stringColPrediction(n){const e=n.length;if(void 0===this.targetCategories)throw new Error("Predicting fails: undefined categories");const r=new Array(e),o=this.targetCategories.length-1,i=t=>Math.max(0,Math.min(t,o));for(let t=0;t<e;++t)r[t]=this.targetCategories[i(Math.round(n[t]))];return t.Column.fromList(t.COLUMN_TYPE.STRING,Zn.PREDICT,r)}intColPrediction(n){const e=n.length,r=new Int32Array(e);for(let t=0;t<e;++t)r[t]=Math.round(n[t]);return t.Column.fromInt32Array(Zn.PREDICT,r,e)}bigIntColPrediction(n){const e=n.length,r=new BigInt64Array(e);for(let t=0;t<e;++t)r[t]=BigInt(Math.round(n[t]));return t.Column.fromBigInt64Array(Zn.PREDICT,r)}}var te=function(t,n,e,r){return new(e||(e=Promise))(function(o,i){function s(t){try{u(r.next(t))}catch(t){i(t)}}function a(t){try{u(r.throw(t))}catch(t){i(t)}}function u(t){var n;t.done?o(t.value):(n=t.value,n instanceof e?n:new e(function(t){t(n)})).then(s,a)}u((r=r.apply(t,n||[])).next())})};const ne=100,ee=8e3;var re;L("Softmax",()=>{O("Performance: 50K samples, 100 features",()=>te(void 0,void 0,void 0,function*(){const t=Fn(5e4,ne,!1).columns,n=t.byIndex(ne);t.remove(n.name);const e=new Yn({classesCount:n.categories.length,featuresCount:t.length});yield e.fit(t,n);const r=e.toBytes();new Yn(void 0,r).predict(t)}),{timeout:ee,benchmark:!0}),O("Correctness",()=>te(void 0,void 0,void 0,function*(){const t=Fn(50,2,!0).columns,n=t.byIndex(2);t.remove(n.name);const e=new Yn({classesCount:n.categories.length,featuresCount:t.length});yield e.fit(t,n);const r=e.toBytes(),o=Un(n,new Yn(void 0,r).predict(t));R(o>.9,!0,`Softmax failed, too small accuracy: ${o}; expected: <= 0.9`)}),{timeout:ee})}),L("XGBoost",()=>{O("Performance: 50K samples, 100 features",()=>te(void 0,void 0,void 0,function*(){const t=Fn(5e4,ne,!1).columns,n=t.byIndex(ne);t.remove(n.name);const e=new Jn;yield e.fit(t,n);const r=e.toBytes();new Jn(r).predict(t)}),{timeout:ee,benchmark:!0}),O("Correctness",()=>te(void 0,void 0,void 0,function*(){const t=Fn(50,2,!0).columns,n=t.byIndex(2);t.remove(n.name);const e=new Jn;yield e.fit(t,n);const r=e.toBytes(),o=Un(n,new Jn(r).predict(t));R(o>.9,!0,`XGBoost failed, too small accuracy: ${o}; expected: <= 0.9`)}),{timeout:ee})}),function(t){t.NO_DATAFRAME="No dataframe is opened",t.NO_MISSING_VALUES="No missing values",t.ONE_AVAILABLE_FEATURE="Not enough of feature columns to apply imputation using the KNN method",t.ONE_FEATURE_SELECTED="Imputation cannot be applied to",t.UNSUPPORTED_COLUMN_TYPE="Unsupported column type",t.UNSUPPORTED_IMPUTATION_STRATEGY="Unsupported imputation strategy",t.KNN_CANNOT_BE_APPLIED="KNN imputer cannot be applied: no columns to be used as features",t.KNN_NO_TARGET_COLUMNS="KNN imputer cannot be applied: no columns with missing values",t.KNN_NO_FEATURE_COLUMNS="KNN imputer cannot be applied: no feature columns",t.KNN_NOT_ENOUGH_OF_ROWS="KNN imputer cannot be applied: not enough of rows",t.KNN_IMPOSSIBLE_IMPUTATION="Imputation is impossible, no features can be used",t.INCORRECT_NEIGHBORS="Incorrect number of neighbors",t.KNN_FAILS="KNN IMPUTATION FAILS",t.CORE_ISSUE="Core issue",t.FAILED_TO_IMPUTE="Failed to impute",t.UNSUPPORTED_FILL_VALUE_TYPE="Unsupported fill value type",t.EMPTY_COLUMN="Column contains just null values",t.FAILS_TO_PREDICT_IMPUTATION_FAILS="Failed to predict imputation fails",t.WRONG_PREDICTIONS="wrong evaluation of KNN imputation fails"}(re||(re={}));const oe="copy";var ie,se;!function(t){t.KNN_IMPUTER="k-NN Imputation",t.TABLE="Table",t.IN_PLACE="In-place",t.COLUMNS="Impute",t.FEATURES="Using",t.CANCEL="CANCEL",t.RUN="RUN",t.OK="OK",t.NEIGHBORS="Neighbors",t.DISTANCE="Distance",t.FILL="Fill",t.MARK="Mark",t.SIMPLE_IMPUTER="Simple impute",t.SETTINGS="Settings",t.KEEP_EMPTY="Keep empty"}(ie||(ie={})),function(t){t.TARGET="Columns with missing values that must be filled",t.FEATURES="Columns with features to be used for determining the 'nearest' elements in the k-NN method",t.IN_PLACE="Defines whether to use in-place imputation or add a new column without missing values",t.METRIC="Type of metric between the feature values",t.WEIGHT="Weight",t.NEIGHBORS="Neighbors count used in the KNN method",t.DISTANCE="Type of distance between elements with the specified features",t.METRIC_SETTINGS="Show additional options",t.FILL_FAILED_ITEMS="Impute missing values using a simple approach: mean, median or most frequent",t.MARK_FAILED_ITEMS="Mark missing values cells with a color",t.FILL_VALUE="Fill value",t.IMPUTATION_SETTINGS="Simple imputation settings",t.KEEP_EMPTY="Defines whether to keep empty missing values failed to be imputed OR fill them using simple imputation",t.RUN="Run imputation using the k-NN method"}(se||(se={}));const ae=[t.COLUMN_TYPE.INT,t.COLUMN_TYPE.FLOAT,t.COLUMN_TYPE.STRING,t.COLUMN_TYPE.DATE_TIME,t.COLUMN_TYPE.QNUM];function ue(n){switch(n.type){case t.COLUMN_TYPE.INT:return t.INT_NULL;case t.COLUMN_TYPE.FLOAT:case t.COLUMN_TYPE.QNUM:case t.COLUMN_TYPE.DATE_TIME:return t.FLOAT_NULL;case t.COLUMN_TYPE.STRING:return n.max;default:throw new Error(re.UNSUPPORTED_COLUMN_TYPE)}}var ce,le,fe,he;function me(n){switch(n){case t.COLUMN_TYPE.STRING:case t.COLUMN_TYPE.DATE_TIME:return{defaultWeight:fe.WEIGHT,defaultMetric:ce.ONE_HOT,availableMetrics:[ce.ONE_HOT]};case t.COLUMN_TYPE.INT:case t.COLUMN_TYPE.FLOAT:case t.COLUMN_TYPE.QNUM:return{defaultWeight:fe.WEIGHT,defaultMetric:ce.DIFFERENCE,availableMetrics:[ce.DIFFERENCE,ce.ONE_HOT]};default:throw new Error(re.UNSUPPORTED_COLUMN_TYPE)}}!function(t){t.ONE_HOT="One-hot",t.DIFFERENCE="Difference"}(ce||(ce={})),(he=le||(le={})).EUCLIDEAN="Euclidean",he.MANHATTAN="Manhattan",function(t){t[t.WEIGHT=1]="WEIGHT",t[t.NEIGHBORS=4]="NEIGHBORS",t[t.IN_PLACE=1]="IN_PLACE",t[t.SELECTED=1]="SELECTED",t[t.KEEP_EMPTY=0]="KEEP_EMPTY"}(fe||(fe={}));const de=e=>{O(`${e} dist, 100K rows, 15 cols, 75 missing vals`,()=>{return r=void 0,o=void 0,s=function*(){const r=function(n){const e=Rn.length,r=[];let o=0;const i=new Map;for(let e=0;e<5;++e){const s=new Int32Array(n),a=`int #${e+1}`,u=[];for(let 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Error(re.KNN_NOT_ENOUGH_OF_ROWS);if(0===r.length)throw new Error(re.KNN_NO_TARGET_COLUMNS);if(0===o.size)throw new Error(re.KNN_NO_FEATURE_COLUMNS);1===o.size&&r.forEach(t=>{if(o.has(t))throw new Error(`${re.KNN_NO_FEATURE_COLUMNS} can be used for the column '${t}'`)}),r.forEach(t=>{if(!i.has(t))throw new Error(`${re.KNN_FAILS}: ${re.WRONG_PREDICTIONS}`)});const c=e.columns;r.forEach(t=>{if(!ae.includes(c.byName(t).type))throw new Error(re.UNSUPPORTED_COLUMN_TYPE)}),o.forEach((t,n)=>{if(!ae.includes(e.getCol(n).type))throw new Error(re.UNSUPPORTED_COLUMN_TYPE)});const l=new Map;return r.forEach(r=>{const f=c.byName(r),h=ue(f),m=f.length,d=f.getRawData(),p=new Uint16Array(f.categories.length),g=[],y=[],v=[],w=[];o.forEach((t,n)=>{if(n!==f.name){const e=c.byName(n);switch(g.push(e.getRawData()),y.push(ue(e)),t.type){case ce.DIFFERENCE:v.push((n,e)=>t.weight*Math.abs(n-e));break;case ce.ONE_HOT:v.push((n,e)=>t.weight*(n===e?0:1))}}});const E=g.length,A=new Uint32Array(g.length),C=new Float32Array(g.length);let _=0;const N=new Array(a);let x=0,b=0,S=0,T=0,I=0;const M=(t,n)=>{A.forEach((e,r)=>{C[r]=v[e](g[e][t],g[e][n])})},O=s===le.EUCLIDEAN?()=>{let t=0;for(let n=0;n<_;++n)t+=C[n]*C[n];return Math.sqrt(t)}:()=>{let t=0;for(let n=0;n<_;++n)t+=Math.abs(C[n]);return Math.sqrt(t)},R=t=>{if(d[t]===h)return!1;for(let n=0;n<_;++n)if(g[A[n]][t]===y[A[n]])return!1;return!0},L=n=>{if((t=>{_=0;for(let n=0;n<E;++n)g[n][t]!==y[n]&&(A[_]=n,++_)})(n),0===_)throw new Error(`${re.KNN_IMPOSSIBLE_IMPUTATION}: the column "${f.name}", row ${n+1}`);x=0;for(let t=0;t<m;++t)if(R(t)&&t!==n){M(n,t);const e=O();if(x<a)N[x]={index:t,dist:e},++x;else{b=0,S=N[0].dist;for(let t=1;t<x;++t)S<N[t].dist&&(S=N[t].dist,b=t);e<S&&(N[b]={index:t,dist:e})}}if(0===x)throw new Error(`${re.KNN_IMPOSSIBLE_IMPUTATION}: the column "${f.name}", row ${n+1}`);if(f.type===t.COLUMN_TYPE.STRING)return(()=>{p.forEach((t,n,e)=>e[n]=0);let t=0;for(t=0;t<x;++t)++p[d[N[t].index]];let n=p[0],e=0;return p.forEach((t,r)=>{t>n&&(n=t,e=r)}),e})();T=0;for(let t=0;t<x;++t)T+=d[N[t].index];return I=T/x,f.type===t.COLUMN_TYPE.INT?Math.round(I):I};if(u){for(const t of i.get(r))try{d[t]=L(t)}catch(e){w.push(t),e instanceof Error||n.shell.error(re.CORE_ISSUE)}w.length>0&&l.set(r,w),f.set(0,f.get(0))}else{const t=f.clone();let o=1,s=`${r}(${oe})`;for(;e.columns.contains(s);)s=`${r}(${oe} ${o})`,++o;t.name=s;const a=t.getRawData();for(const t of i.get(r))try{a[t]=L(t)}catch(e){w.push(t),e instanceof Error||n.shell.error(re.CORE_ISSUE)}w.length>0&&l.set(s,w),t.set(0,t.get(0)),e.columns.add(t)}}),l}(o,i,s,a,e,5,!0);let c=0;u.forEach((t,n)=>c+=t.length),R(c,0,`Failed to impute ${c} missing values`)},new((i=void 0)||(i=Promise))(function(t,n){function e(t){try{u(s.next(t))}catch(t){n(t)}}function a(t){try{u(s.throw(t))}catch(t){n(t)}}function u(n){var r;n.done?t(n.value):(r=n.value,r instanceof i?r:new i(function(t){t(r)})).then(e,a)}u((s=s.apply(r,o||[])).next())});var r,o,i,s},{timeout:1e4,benchmark:!0})};L("Missing values imputation",()=>{de(le.EUCLIDEAN),de(le.MANHATTAN)});var pe,ge=e(6572);function ye(t){if(t<=0||t>=1)throw new Error(pe.INCORRECT_SIGNIFICANCE_LEVEL)}function ve(t){const n=t.size;return n<=1?0:(t.sumOfSquares-Math.pow(t.sum,2)/n)/(n-1)}function we(t,n,e){ye(e);const r=ve(t),o=ve(n);return 0===r||0===o?r===o:r/o<ge.centralF.inv(1-e,t.size-1,n.size-1)}!function(t){t.NON_EQUAL_FACTORS_VALUES_SIZE="non-equal sizes of factor and values arrays",t.INCORRECT_SIGNIFICANCE_LEVEL="incorrect significance level",t.NON_EQUAL_VARIANCES="non-equal variances",t.NON_NORMAL_DISTRIB="non-normal distribution",t.UNSUPPORTED_COLUMN_TYPE="unsupported feature column type",t.INCORRECT_CATEGORIES_COL_TYPE="incorrect categories column type",t.SINGLE_FACTOR="single category features",t.CATS_EQUAL_SIZE="single value in each category",t.NO_FEATURE_VARIATION="no feature variation",t.NO_FEATURE_VARIATION_WITHIN_GROUPS="no feature variation within groups"}(pe||(pe={}));class Ee{constructor(t,n,e){if(this.nullsCount=0,t.length!==n.length)throw new Error(pe.NON_EQUAL_FACTORS_VALUES_SIZE);if(!(n.stats.stdev>0))throw new Error(pe.NO_FEATURE_VARIATION);this.setStats(t,n,e)}areVarsEqual(t){const n=this.catCount;if(1===n)return!0;const e={sum:this.sums[0],sumOfSquares:this.sumsOfSquares[0],size:this.subSampleSizes[0]};for(let r=1;r<n;++r)if(!we(e,{sum:this.sums[r],sumOfSquares:this.sumsOfSquares[r],size:this.subSampleSizes[r]},t))return!1;return!0}getOneWayAnova(){let t=0,n=0,e=0,r=this.catCount,o=r;for(let i=0;i<r;++i)0!==this.subSampleSizes[i]?(t+=this.sums[i],n+=this.sumsOfSquares[i],e+=Math.pow(this.sums[i],2)/this.subSampleSizes[i]):--o;if(r=o,1===r)throw new Error(pe.SINGLE_FACTOR);const i=this.size-this.nullsCount;if(i===r)throw new Error(pe.CATS_EQUAL_SIZE);const s=n-Math.pow(t,2)/i,a=e-Math.pow(t,2)/i,u=s-a;if(0===u)throw new Error(pe.NO_FEATURE_VARIATION_WITHIN_GROUPS);const c=r-1,l=i-r,f=a/c,h=u/l,m=f/h;return{ssBn:a,ssWn:u,ssTot:s,dfBn:c,dfWn:l,dfTot:i-1,msBn:f,msWn:h,fStat:m,pValue:1-ge.centralF.cdf(m,c,l)}}setStats(n,e,r){const o=e.type,i=e.length,s=ue(e);switch(o){case t.COLUMN_TYPE.INT:case t.COLUMN_TYPE.FLOAT:const o=r;this.catCount=o,this.size=i;const a=e.getRawData(),u=n.getRawData(),c=new Float64Array(o).fill(0),l=new Float64Array(o).fill(0),f=new Int32Array(o).fill(0);let h;if(n.type==t.COLUMN_TYPE.BOOL){let t=0,n=0,e=u[0];const r=8*u.BYTES_PER_ELEMENT-1;for(let o=0;o<i;++o)h=1&e>>n,a[o]!==s?(c[h]+=a[o],l[h]+=Math.pow(a[o],2),++f[h]):++this.nullsCount,++n,n>r&&(n=0,++t,e=u[t])}else{const t=n.stats.missingValueCount>0?ue(n):-1;for(let n=0;n<i;++n)h=u[n],h!==t&&a[n]!==s?(c[h]+=a[n],l[h]+=Math.pow(a[n],2),++f[h]):++this.nullsCount}this.sums=c,this.sumsOfSquares=l,this.subSampleSizes=f;break;default:throw new Error(pe.UNSUPPORTED_COLUMN_TYPE)}}}function Ae(t,n,e,r=!0){ye(e);const o=t.stats.uniqueCount;if(o<2)throw new Error(pe.SINGLE_FACTOR);const i=new Ee(t,n,o);if(r&&!i.areVarsEqual(e))throw new Error(pe.NON_EQUAL_VARIANCES);const s=i.getOneWayAnova();return{anovaTable:s,fCritical:ge.centralF.inv(1-e,s.dfBn,s.dfWn),significance:e}}var Ce=function(t,n,e,r){return new(e||(e=Promise))(function(o,i){function s(t){try{u(r.next(t))}catch(t){i(t)}}function a(t){try{u(r.throw(t))}catch(t){i(t)}}function u(t){var n;t.done?o(t.value):(n=t.value,n instanceof e?n:new e(function(t){t(n)})).then(s,a)}u((r=r.apply(t,n||[])).next())})};const _e=.05,Ne=!1,xe=t.Column.fromList(t.COLUMN_TYPE.INT,"features",[9,12,4,8,7,4,6,8,2,10,1,3,4,5,2]),be=t.Column.fromStrings("features",["A","A","A","A","A","B","B","B","B","B","C","C","C","C","C"]);var Se;!function(t){t[t.DF_BN=2]="DF_BN",t[t.DF_TOT=14]="DF_TOT",t[t.DF_WN=12]="DF_WN",t[t.SS_BN=63.333]="SS_BN",t[t.SS_TOT=147.333]="SS_TOT",t[t.SS_WN=84]="SS_WN",t[t.MS_BN=31.666]="MS_BN",t[t.MS_WN=7]="MS_WN",t[t.F_STAT=4.523]="F_STAT",t[t.F_CRIT=3.885]="F_CRIT",t[t.P_VAL=.034]="P_VAL"}(Se||(Se={})),L("ANOVA",()=>{O("Performance: 1M rows demog",()=>Ce(void 0,void 0,void 0,function*(){const t=n.data.demo.demog(1e6),e=t.col("race"),r=t.col("height");new Ee(e,r,e.stats.uniqueCount).areVarsEqual(_e),Ae(e,r,_e,Ne)}),{timeout:4e3,benchmark:!0}),O("Correctness",()=>Ce(void 0,void 0,void 0,function*(){const t=Ae(be,xe,_e,Ne),n=t.anovaTable;R(n.dfBn,Se.DF_BN,"Incorrect degrees of freedom: dfBn"),R(n.dfTot,Se.DF_TOT,"Incorrect degrees of freedom: dfTot"),R(n.dfWn,Se.DF_WN,"Incorrect degrees of freedom: dfWn");const e=(t,n)=>Math.abs(t-n)<.01;R(e(n.ssBn,Se.SS_BN),!0,"Incorrect sum of squares: ssBn"),R(e(n.ssTot,Se.SS_TOT),!0,"Incorrect sum of squares: ssTot"),R(e(n.ssWn,Se.SS_WN),!0,"Incorrect sum 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t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,o=this.lengthInInts;for(let t=0;t<o;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,o=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(o)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,o=!0,r=!0){if(n&&r&&this.setAll(!e,!1),r)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(o)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let o=t;o<e;++o)n.push(this.getBit(o));return H.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let o=t;o<e;++o)n.push(this.getBit(o));return n}setRange(t,e,n,o=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const r=Math.min(t,e),i=Math.max(t,e);if(n)for(let t=r;t<=i;t++)this.setTrue(t);else for(let t=r;t<=i;t++)this.setFalse(t);return this.incrementVersion(o),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,n=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const o=this._length;this.setLength(this._length+e);for(let n=o-1;n>=t;n--)this.setBit(n+e,this.getBit(n));for(let o=t;o<t+e;o++)this.setBit(o,n)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let n=t;n<this._length-e;n++)this.setBit(n,this.getBit(n+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let n=0;for(let o=-1;-1!=(o=t.findNext(o,!e));)this.setFast(n++,this.getBit(o));this._length=n,this._version++}return this}getBit(t){return!!(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,n=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=H._onBitCount[255&t];let n=this._data[e];const o=31&this._length;for(0!=o&&(n&=~(4294967295<<o));0!=n;n>>>=8)this._selectedCount+=H._onBitCount[255&n];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)e+=t(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)e+=t(n)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let n=0;const o=this.lengthInInts;let r=0;for(;r<o-1;r++)for(let e=this._data[r]&t._data[r];0!=e;e>>>=8)n+=H._onBitCount[255&e];let i=this._data[r]&t._data[r];const s=31&this._length;for(0!=s&&(i&=~(4294967295<<s));0!=i;i>>>=8)n+=H._onBitCount[255&i];return e?n:this._length-n}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let n=31&(t=t<0?0:t+1);const o=this.lengthInInts;for(let r=Math.floor(t/32);r<o;r++){let o=e?this._data[r]:~this._data[r];if(0!=n)o&=4294967295<<n&4294967295,n=0;else if(!e&&-4294967296==o)continue;for(let e=0;0!=o;e+=8,o>>>=8){const n=H._firstOnBit[255&o];if(n>=0)return(t=n+32*r+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let n=1+(t=t<0?this._length-1:t-1)&31;for(let o=Math.floor(t/32);o>=0;o--){let t=e?this._data[o]:~this._data[o];0!=n&&(t&=~(4294967295<<n),n=0);for(let e=24;0!=t;e-=8,t<<=8){const n=H._lastOnBit[t>>>24];if(n>=0)return n+32*o+e}}return-1}}function q(t={}){const e=function(){if(!t||!t.scoringMatrix||!t.alphabetIndexes)return(t,e)=>t===e?0:1;if(t.scoringMatrix.length!==Object.keys(t.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const e=t.alphabetIndexes,n=t.scoringMatrix,o=Math.min(...Object.keys(e).map(t=>t.charCodeAt(0)))+1,r=new Float32Array((n.length+o)*(n.length+o));return Object.entries(e).forEach(([t,o])=>{const i=n[o];Object.entries(e).forEach(([e,o])=>{r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]=i[o]})}),(t,e)=>1-r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]}(),n=t?.threshold??0;return(t,o)=>{let r=0;const i=t.length,s=o.length,a=Math.ceil(Math.max(i,s)*(1-n));i!==s&&(r=Math.abs(i-s));let l=0;for(let n=0;n<Math.min(i,s);n++)if(t[n]!==o[n]&&(l+=e(t[n],o[n]),l>a))return 1;return l+=r,l/=Math.max(i,s),l}}H._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),H._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),H._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7]);const Y={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var 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dt=t=>null==t;function ht(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map(t=>t.name).join(", ")})`}async function mt(e,n,o,r,i,a,l,u=!0,c=!1,f={preprocessingFuncArgs:[]},d={},h=null,m={},p){const g={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(n.length!==r.length||n.length!==a.length||n.length!==i.length||n.length!==f.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=u?d.tableView??I.shell.tableView(e.name)??I.shell.addTableView(e):null,y=async()=>{const y=t.TaskBarProgressIndicator.create(`Initializing ${d.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const w=function(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter(t=>t.includes(e[0])).length+1;return e.map(t=>`${t}_${n}`)}(e);function C(r,i,s){let 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function(t,e,n,o,r,i,a){if(!i.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==i.distanceFnArgs.length||t.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(l,u){const c=new Worker(new URL(s.p+s.u(234),s.b));c.postMessage({columnsData:t,distanceMetrics:e,method:n,options:i,weights:o,aggregationMethod:r});const f=I.events.onCustomEvent(ct).subscribe(()=>{try{c?.terminate()}finally{f.unsubscribe()}});c.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:o}})=>{dt(n)||dt(o)?(f.unsubscribe(),t?u(t):l(e),setTimeout(()=>c.terminate(),100)):a&&a(n,o,e)}})}(t,n,e,o,r,i,a);return l=l.map(t=>function(t){const e=t.length;let n=0,o=0;for(let r=0;r<e;++r)n+=t[r],o+=Math.pow(t[r],2);const r=n/e,i=1/Math.sqrt(o/e-Math.pow(r,2));for(let n=0;n<e;++n)t[n]=(t[n]-r)*i;return t}(t)),l}(u.map(t=>t.entries),o,h,m,l,f,d[rt]?void 0:C))}catch(t){u(t)}}),E=await m;return y.close(),h.unsubscribe(),E}const b=await E();if(c&&b){const x=t.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(t,e,n,o){return r=this,i=void 0,l=function*(){return new Promise(function(r,i){const a=new Worker(new URL(s.p+s.u(682),s.b));a.postMessage({embedX:t,embedY:e,minPts:o,epsilon:n}),a.onmessage=({data:{error:t,clusters:e}})=>{a.terminate(),t?i(t):r(e)}})},new((a=void 0)||(a=Promise))(function(t,e){function n(t){try{s(l.next(t))}catch(t){e(t)}}function o(t){try{s(l.throw(t))}catch(t){e(t)}}function s(e){var r;e.done?t(e.value):(r=e.value,r instanceof a?r:new a(function(t){t(r)})).then(n,o)}s((l=l.apply(r,i||[])).next())});var r,i,a,l}(b[0],b[1],f.dbScanEpsilon??.01,f.dbScanMinPts??4),N=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(N).init(t=>_[t].toString()),A&&(A.props.colorColumnName=N)}catch(M){I.shell.error("Clustering embeddings failed"),console.error(M)}finally{x.close()}}if(b){const T=e.columns.byName(w[0]),S=e.columns.byName(w[1]);if(T.init(t=>b[0][t]),S.init(t=>b[1][t]),h)try{const O=h.inputs[0].name,L=h.inputs[1].name;await h.prepare({[O]:T,[L]:S,...m}).call(!0)}catch(P){I.shell.error("Post-processing failed"),console.error(P)}if(A)return ot.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(R){I.shell.error("Dimensionality reduction failed"),console.error(R),y.close(),A&&ot.setUpdateIndicator(A.root,!1)}};return new Promise(async(t,n)=>{try{if(d.fastRowCount&&e.rowCount>d.fastRowCount&&!d[rt])ot.dialog().add(ot.divText("Analysis might take several minutes. 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T-SNE",()=>{C("Numeric column",()=>pt(void 0,void 0,void 0,function*(){yield vt([gt.AGE],L.T_SNE,[k.Difference])}),{timeout:3e4}),C("String column",()=>pt(void 0,void 0,void 0,function*(){yield vt([gt.SEX],L.T_SNE,[P.Onehot])}),{timeout:3e4}),C("Numeric and string columns",()=>pt(void 0,void 0,void 0,function*(){yield vt([gt.SEX,gt.AGE],L.T_SNE,[P.Onehot,k.Difference])})),C("All demog columns",()=>pt(void 0,void 0,void 0,function*(){const e=I.data.demo.demog(10).columns.toList().filter(t=>Object.values(gt).includes(t.name)),n=e.map(e=>e.type===t.COLUMN_TYPE.STRING?P.Onehot:k.Difference),o=e.map(t=>t.name);yield vt(o,L.T_SNE,n)}))});const yt={i32:"HEAP32",f32:"HEAPF32"},At={i32:Int32Array,f32:Float32Array},wt={i32:2,f32:2},Ct={i32:DG.Column.fromInt32Array,f32:DG.Column.fromFloat32Array};class Et{constructor(t){this.data=t}complementArrOfParams(t){t.push(this.data)}complementArrOfTypes(t){t.push("number")}allocateMemoryForBuffer(t){}isMemoryForBufferAllocated(){return!0}putDataToBuffer(t){}getDataFromBuffer(t){}freeBuffer(t){}}class bt extends Et{constructor(t,e,n=!1){super(t),this.type=e,this.toUpdate=n,this.buf=0,this.numOfRows=t.length}complementArrOfParams(t){t.push(this.buf),t.push(this.numOfRows)}complementArrOfTypes(t){t.push("number"),t.push("number")}allocateMemoryForBuffer(t){this.buf=t._malloc(this.numOfRows*At[this.type].BYTES_PER_ELEMENT)}isMemoryForBufferAllocated(){return 0!=this.buf}putDataToBuffer(t){if(this.isMemoryForBufferAllocated()){const e=this.type,n=wt[e],o=t[yt[e]];let r=null;const i=this.data;r="int"==i.type&&"i32"==e||"double"==i.type&&"f32"==e?i.getRawData():new At[e](i.getRawData()),r&&o.set(r,this.buf>>n)}}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const 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0!=this.buf}putDataToBuffer(t){if(this.isMemoryForBufferAllocated()){const e=this.type,n=wt[e],o=t[yt[e]],r=At[e].BYTES_PER_ELEMENT;for(let t=0;t<this.numOfColumns;t++){let i=null;const s=this.data[t];i="int"==s.type&&"i32"==e||"double"==s.type&&"f32"==e?s.getRawData():new At[e](s.getRawData()),null!=i&&o.set(i,this.buf+t*this.numOfRows*r>>n)}}}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const e=this.type,n=t[yt[e]],o=this.numOfRows,r=this.numOfColumns,i=new At[e](n.buffer,this.buf,o*r);for(let t=0;t<r;t++){const e=this.data[t].getRawData();for(let n=0;n<o;n++)e[n]=i[n+t*o]}}}freeBuffer(t){this.isMemoryForBufferAllocated()&&(t._free(this.buf),this.buf=0)}}class Nt extends _t{constructor(t,e,n){super([[]],t,!0),this.data=[],this.numOfColumns=n,this.numOfRows=e}putDataToBuffer(t){}getDataFromBuffer(t){if(this.toUpdate&&this.isMemoryForBufferAllocated()){const 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features (just one numeric columns without missing values)",t.EMPTY_DF="Dataframe is empty",t.PREDICT="Predictors must not contain a response variable",t.ENOUGH="Not enough of features",t.COMP_LIN_PLS="Components count must be less than the number of features",t.COMP_QUA_PLS="Too large components count for the quadratic PLS regression",t.COMP_ROWS="Components count must not exceed the number of rows",t.COMPONENTS="Components count must be at least 1",t.INV_INP="Invalid inputs",t.NULL_COMPS="Components count is not specified"}(ee||(ee={})),function(t){t.PREDICT="Predict",t.USING="Using",t.COMPONENTS="Components",t.PLS="PLS",t.MVA="Multivariate Analysis (PLS)",t.RUN="RUN",t.NAMES="Names",t.MODEL="Observed vs. Predicted",t.FEATURE="Feature",t.REGR_COEFS="Regression Coefficients",t.XLOADING="x.loading.p",t.LOADINGS="Loadings",t.XSCORE="x.score.t",t.YSCORE="y.score.u",t.SCORES="Scores",t.EXPL_VAR="Explained Variance",t.EXPLORE="Explore",t.FEATURES="Feature 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model"}(oe||(oe={})),function(t){t.PLS="/help/explore/multivariate-analysis#pls-components",t.MVA="/help/explore/multivariate-analysis",t.MODEL="/help/explore/multivariate-analysis#observed-vs-predicted",t.COEFFS="/help/explore/multivariate-analysis#regression-coefficients",t.LOADINGS="/help/explore/multivariate-analysis#loadings",t.EXPL_VARS="/help/explore/multivariate-analysis#explained-variance",t.SCORES="/help/explore/multivariate-analysis#scores"}(re||(re={})),function(t){t[t.DEFAULT=3]="DEFAULT",t[t.MIN=1]="MIN"}(ie||(ie={})),function(t){t.PREFIX="PLS",t.SUFFIX="(predicted)",t.COMP="component",t.COMPS="components"}(se||(se={})),function(t){t[t.PREDICTION=0]="PREDICTION",t[t.REGR_COEFFS=1]="REGR_COEFFS",t[t.T_SCORES=2]="T_SCORES",t[t.U_SCORES=3]="U_SCORES",t[t.X_LOADINGS=4]="X_LOADINGS",t[t.Y_LOADINGS=5]="Y_LOADINGS"}(ae||(ae={}));const ue=[.49,.79,.99];var ce;!function(t){t.AXIS="#838383",t.CIRCLE="#0000FF",t.INVALID="#EB6767",t.VALID_TEXT="#4d5261",t.VALID_LINE="#dbdcdf"}(ce||(ce={})),[{caption:ne.MODEL,text:"Closer to the line means better price prediction."},{caption:ne.SCORES,text:"The latent factor values for each sample reflect the similarities and dissimilarities among observations."},{caption:ne.LOADINGS,text:"The impact of each feature on the latent factors: higher loading means stronger influence."},{caption:ne.REGR_COEFS,text:"Parameters of the obtained model: features make different contribution to the prediction."},{caption:ne.EXPL_VAR,text:"How well the latent components fit source data: closer to one means better fit."}].map(t=>`# ${t.caption}\n\n${t.text}`).join("\n\n"),re.MVA;function fe(t){return e=this,n=void 0,r=function*(){Zt(t.features,t.components),zt(t.predict),Qt(t.predict);const e=yield async function(t,e,n,o){return new Promise((t,r)=>{const i=new Worker(new 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s=this.getRegrCoeffs(e,n,r.regressionCoefficients),a=this.getLoadings(o,r.xLoadings);this.specn={names:i,params:s,loadings:a,components:o,dim:e.length,scores:this.getScoresDf(r)},this.computeExplVars(n.length,o,r.yLoadings)},new((s=void 0)||(s=Promise))(function(t,e){function n(t){try{l(a.next(t))}catch(t){e(t)}}function o(t){try{l(a.throw(t))}catch(t){e(t)}}function l(e){var r;e.done?t(e.value):(r=e.value,r instanceof s?r:new s(function(t){t(r)})).then(n,o)}l((a=a.apply(r,i||[])).next())});var r,i,s,a}getLoadings(t,e){const n=Array(t),o=e[0].length+1;for(let r=0;r<t;++r)n[r]=new Float32Array(o),n[r].set(e[r].getRawData());return n}getRegrCoeffs(t,e,n){const o=t.length,r=new Float32Array(o+1),i=n.getRawData();let s=0;for(let e=0;e<o;++e)r[e]=i[e],s+=i[e]*t.byIndex(e).stats.avg;return r[o]=e.stats.avg-s,r}computeExplVars(t,e,n){if(null===this.specn)throw new Error("Failed to compute explained variances");const o=n.getRawData(),r=this.specn.loadings[0].length-1;let i=Math.pow(o[0],2)/t;this.specn.loadings[0][r]=i;for(let n=1;n<e;++n)i+=Math.pow(o[n],2)/t,this.specn.loadings[n][r]=i}toBytes(){if(null===this.specn)throw new Error("Failed to pack untrained model");const e=t.DataFrame.fromColumns([t.Column.fromStrings(ne.FEATURES,this.specn.names),t.Column.fromFloat32Array(ne.REGR_COEFS,this.specn.params)]);this.specn.loadings.forEach((n,o)=>e.columns.add(t.Column.fromFloat32Array(`${ne.XLOADING}${o+1}`,n)));const n=e.toByteArray(),o=n.length,r=this.specn.scores.toByteArray(),i=r.length,s=o+i+8,a=new Uint8Array(64*(Math.ceil(s/64)+1)),l=new Uint32Array(a.buffer,0,2);return l[0]=o,l[1]=i,a.set(n,8),a.set(r,8+o),a}predict(t){if(null===this.specn)throw new Error("Predicting failed: model is not trained");return me(t,this.specn.params)}loadingsParamsViewers(){if(null===this.specn)throw new Error("Failed to create loadings and parameters viewers: untrained model");const e=[],n=this.specn.dim,o=t.DataFrame.fromColumns([t.Column.fromStrings(ne.FEATURES,this.specn.names.slice(0,-1)),t.Column.fromFloat32Array(ne.REGR_COEFS,this.specn.params,n)]),r=o.columns,i=r.length,s=this.specn.components;return this.specn.loadings.forEach((e,r)=>o.columns.add(t.Column.fromFloat32Array(`${ne.XLOADING}${r+1}`,e,n))),e.push(t.Viewer.scatterPlot(o,{title:ne.LOADINGS,xColumnName:r.byIndex(i).name,yColumnName:r.byIndex(i+(s>1?1:0)).name,markerType:t.MARKER_TYPE.CIRCLE,labelFormColumnNames:[ne.FEATURES],help:re.LOADINGS})),e.push(t.Viewer.barChart(o,{title:ne.REGR_COEFS,splitColumnName:ne.FEATURES,valueColumnName:ne.REGR_COEFS,valueAggrType:t.AGG.AVG,help:re.COEFFS,showValueSelector:!1,showStackSelector:!1})),e}explVarsViewer(){if(null===this.specn)throw new Error("Failed to create exaplained variances viewer: untrained model");const e=this.specn.components,n=this.specn.dim,o=new Array(e),r=new Float32Array(e);o[0]=`${se.COMP} 1`,r[0]=this.specn.loadings[0][n];for(let t=1;t<e;++t)o[t]=`${se.COMPS} ${t+1}`,r[t]=this.specn.loadings[t][n];return t.Viewer.barChart(t.DataFrame.fromColumns([t.Column.fromStrings(se.COMPS,o),t.Column.fromFloat32Array(ne.EXPL_VAR,r)]),{title:ne.EXPL_VAR,splitColumnName:se.COMPS,valueColumnName:ne.EXPL_VAR,valueAggrType:t.AGG.AVG,help:re.EXPL_VARS,showCategorySelector:!1,showStackSelector:!1,showValueSelector:!1})}viewers(){if(null===this.specn)throw new Error("Failed to create viewers: untrained model");const t=this.loadingsParamsViewers();return t.push(this.explVarsViewer(),this.getScoresScatter()),t}getScoresDf(e){const n=e.tScores,o=e.uScores;return n.forEach((t,e)=>t.name=`${ne.XSCORE}${e+1}`),o.forEach((t,e)=>t.name=`${ne.YSCORE}${e+1}`),t.DataFrame.fromColumns(n.concat(o))}getScoresScatter(){if(null===this.specn)throw new Error("Failed to create scores scatter: untrained model");const 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0,function*(){const t=we(1e5,_e,1).columns,e=t.byIndex(_e),n=yield he(t,e),o=new Uint8Array(n.buffer);me(t,new Float32Array(o.buffer))}),{timeout:Ne,benchmark:!0}),C("Correctness",()=>xe(void 0,void 0,void 0,function*(){const t=we(100,2,1).columns,e=t.byIndex(2),n=yield he(t,e),o=new Uint8Array(n.buffer),r=me(t,new Float32Array(o.buffer)),i=Ce(r,r);E(i<Me,!0,`Incorrect linear regression computations, error is too big: ${i}; expected: < 0.1`)}),{timeout:Ne})});var Te=function(t,e,n,o){return new(n||(n=Promise))(function(r,i){function s(t){try{l(o.next(t))}catch(t){i(t)}}function a(t){try{l(o.throw(t))}catch(t){i(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n(function(t){t(e)})).then(s,a)}l((o=o.apply(t,e||[])).next())})};const Se="Avg-s",Oe="Stddev-s";var Ie;!function(t){t[t.MAX_SAMLPES=5e4]="MAX_SAMLPES",t[t.MAX_FEATURES=100]="MAX_FEATURES"}(Ie||(Ie={}));class Le{static isApplicable(e,n){for(const t of e)if(!t.matches("numerical"))return!1;return 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URL(s.p+s.u(501),s.b));c.postMessage({features:this.normalized(t),transposed:this.transposed(t),oneHot:a.oneHot,classesWeights:a.weights,targetRaw:e.getRawData(),iterations:n,rate:o,penalty:r,tolerance:i}),c.onmessage=function(t){c.terminate(),l(t.data.params),console.log(`Loss: ${t.data.loss}`)}})})}}var Pe,Re,Fe;!function(t){t[t.ITERATIONS=20]="ITERATIONS",t[t.ETA=.3]="ETA",t[t.MAX_DEPTH=6]="MAX_DEPTH",t[t.LAMBDA=1]="LAMBDA",t[t.ALPHA=0]="ALPHA"}(Pe||(Pe={})),function(t){t[t.SAMLPES_HIGH=1e5]="SAMLPES_HIGH",t[t.SAMLPES_MID=5e4]="SAMLPES_MID",t[t.SAMPLES_LOW=1e4]="SAMPLES_LOW",t[t.FEATURES_HIGH=10]="FEATURES_HIGH",t[t.FEATURES_MID=20]="FEATURES_MID",t[t.FEATURES_LOW=100]="FEATURES_LOW"}(Re||(Re={})),function(t){t[t.MODEL=1e7]="MODEL",t[t.UTILS=1]="UTILS",t[t.PACK=128]="PACK",t[t.SIZE=4]="SIZE"}(Fe||(Fe={}));const De=t.FLOAT_NULL;var Be;!function(t){t.PREDICT="Prediction",t.TYPE="Type",t.PARAMS="Params count",t.CATS="Categories",t.CATS_SIZE="Categories size"}(Be||(Be={}));class ke{static isApplicable(t,e){for(const e of t)if(!e.matches("numerical"))return!1;return!(!e.matches("numerical")&&!e.matches("string"))}static isInteractive(t,e){const n=t.length,o=e.length;return o<=Re.SAMPLES_LOW?n<=Re.FEATURES_LOW:o<=Re.SAMLPES_MID?n<=Re.FEATURES_MID:o<=Re.SAMLPES_HIGH&&n<=Re.FEATURES_HIGH}constructor(e){var n;if(this.modelParams=void 0,this.targetType=void 0,this.targetCategories=void 0,e)try{let o=0;const r=new Uint32Array(e.buffer,o,1)[0];o+=Fe.SIZE;const i=t.DataFrame.fromByteArray(new Uint8Array(e.buffer,o,r));o+=r,this.targetType=i.get(Be.TYPE,0);const s=i.get(Be.PARAMS,0),a=i.get(Be.CATS_SIZE,0);if(a>0){const r=t.DataFrame.fromByteArray(new Uint8Array(e.buffer,o,a));this.targetCategories=null===(n=r.col(Be.CATS))||void 0===n?void 0:n.toList()}o+=a,o=4*Math.ceil(o/4),this.modelParams=new Int32Array(e.buffer,o,s)}catch(t){throw new Error(`Failed to load model: ${t instanceof Error?t.message:"the platform issue"}`)}}fit(e,n){return o=this,r=arguments,a=function*(e,n,o=Pe.ITERATIONS,r=Pe.ETA,i=Pe.MAX_DEPTH,a=Pe.LAMBDA,l=Pe.ALPHA){this.targetType=n.type,this.targetType===t.COLUMN_TYPE.STRING&&(this.targetCategories=n.categories),this.modelParams=yield async function(t,e,n,o,r,i,a,l,u,c){return new Promise((f,d)=>{const h=e.length,m=t.length,p=new Float32Array(h*m);let g,v;for(let e=0;e<m;++e){v=t.byIndex(e).getRawData(),g=e*h;for(let t=0;t<h;++t)p[t+g]=v[t]}const y=new Worker(new URL(s.p+s.u(990),s.b));y.postMessage({features:p,target:e.getRawData(),samplesCount:h,featuresCount:m,modelReserve:u,utilsLength:c,iterations:o,eta:r,maxDepth:i,lambda:a,alpha:l,missingValue:n}),y.onmessage=function(t){y.terminate(),f(t.data.params)}})}(e,n,De,o,r,i,a,l,Fe.MODEL,Fe.UTILS)},new((i=void 0)||(i=Promise))(function(t,e){function n(t){try{l(a.next(t))}catch(t){e(t)}}function s(t){try{l(a.throw(t))}catch(t){e(t)}}function l(e){var o;e.done?t(e.value):(o=e.value,o instanceof i?o:new i(function(t){t(o)})).then(n,s)}l((a=a.apply(o,r||[])).next())});var o,r,i,a}predict(e){if(void 0===this.modelParams)throw new Error("Failed to apply non-trained model");const n=function(t,e,n){const o=t.byIndex(0).length,r=t.length,i=n.length;let s=XGBoostModule.HEAPF32;const a=XGBoostModule.HEAP32,l=XGBoostModule._malloc(o*r*4),u=XGBoostModule._malloc(4*o),c=XGBoostModule._malloc(4*i);for(let e=0;e<r;++e){const n=t.byIndex(e).getRawData();for(let t=0;t<o;++t)s[l/4+t+e*o]=n[t]}for(let t=0;t<i;++t)a[c/4+t]=n[t];XGBoostModule._predict(l,o,r,e,c,i,u,o),s=XGBoostModule.HEAPF32;const f=new Float32Array(o);for(let t=0;t<o;++t)f[t]=s[u/4+t];return XGBoostModule._free(l),XGBoostModule._free(u),XGBoostModule._free(c),f}(e,De,this.modelParams);switch(this.targetType){case t.COLUMN_TYPE.STRING:return this.stringColPrediction(n);case t.COLUMN_TYPE.INT:return this.intColPrediction(n);case t.COLUMN_TYPE.BIG_INT:return this.bigIntColPrediction(n);default:return t.Column.fromFloat32Array(Be.PREDICT,n)}}toBytes(){if(void 0===this.modelParams||void 0===this.targetType)throw new Error("Failed to pack non-trained model");const e=void 0!==this.targetCategories?t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.STRING,Be.CATS,this.targetCategories)]).toByteArray():void 0,n=void 0!==e?e.length:0,o=this.modelParams.length*this.modelParams.BYTES_PER_ELEMENT,r=t.DataFrame.fromColumns([t.Column.fromStrings(Be.TYPE,[this.targetType]),t.Column.fromInt32Array(Be.PARAMS,new Int32Array([this.modelParams.length])),t.Column.fromInt32Array(Be.CATS_SIZE,new Int32Array([n]))]).toByteArray(),i=r.length,s=64*Math.ceil((Fe.SIZE+i+n+o+Fe.PACK)/64),a=new Uint8Array(s);let l=0;return new Uint32Array(a.buffer,l,1)[0]=i,l+=Fe.SIZE,a.set(r,l),l+=i,n>0&&a.set(e,l),l+=n,l=4*Math.ceil(l/4),a.set(new Uint8Array(this.modelParams.buffer),l),a}stringColPrediction(e){const n=e.length;if(void 0===this.targetCategories)throw new Error("Predicting fails: undefined 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o=n.toBytes(),r=be(e,new ke(o).predict(t));E(r>.9,!0,`XGBoost failed, too small accuracy: ${r}; expected: <= 0.9`)}),{timeout:Ge})}),function(t){t.NO_DATAFRAME="No dataframe is opened",t.NO_MISSING_VALUES="No missing values",t.ONE_AVAILABLE_FEATURE="Not enough of feature columns to apply imputation using the KNN method",t.ONE_FEATURE_SELECTED="Imputation cannot be applied to",t.UNSUPPORTED_COLUMN_TYPE="Unsupported column type",t.UNSUPPORTED_IMPUTATION_STRATEGY="Unsupported imputation strategy",t.KNN_CANNOT_BE_APPLIED="KNN imputer cannot be applied: no columns to be used as features",t.KNN_NO_TARGET_COLUMNS="KNN imputer cannot be applied: no columns with missing values",t.KNN_NO_FEATURE_COLUMNS="KNN imputer cannot be applied: no feature columns",t.KNN_NOT_ENOUGH_OF_ROWS="KNN imputer cannot be applied: not enough of rows",t.KNN_IMPOSSIBLE_IMPUTATION="Imputation is impossible, no features can be used",t.INCORRECT_NEIGHBORS="Incorrect number of neighbors",t.KNN_FAILS="KNN IMPUTATION FAILS",t.CORE_ISSUE="Core issue",t.FAILED_TO_IMPUTE="Failed to impute",t.UNSUPPORTED_FILL_VALUE_TYPE="Unsupported fill value type",t.EMPTY_COLUMN="Column contains just null values",t.FAILS_TO_PREDICT_IMPUTATION_FAILS="Failed to predict imputation fails",t.WRONG_PREDICTIONS="wrong evaluation of KNN imputation fails"}($e||($e={}));const He="copy";var qe,Ye;!function(t){t.KNN_IMPUTER="k-NN Imputation",t.TABLE="Table",t.IN_PLACE="In-place",t.COLUMNS="Impute",t.FEATURES="Using",t.CANCEL="CANCEL",t.RUN="RUN",t.OK="OK",t.NEIGHBORS="Neighbors",t.DISTANCE="Distance",t.FILL="Fill",t.MARK="Mark",t.SIMPLE_IMPUTER="Simple impute",t.SETTINGS="Settings",t.KEEP_EMPTY="Keep empty"}(qe||(qe={})),function(t){t.TARGET="Columns with missing values that must be filled",t.FEATURES="Columns with features to be used for determining the 'nearest' elements in the k-NN method",t.IN_PLACE="Defines whether to use in-place imputation or add a new column without missing values",t.METRIC="Type of metric between the 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groups"}(Je||(Je={}));class rn{constructor(t,e,n){if(this.nullsCount=0,t.length!==e.length)throw new Error(Je.NON_EQUAL_FACTORS_VALUES_SIZE);if(!(e.stats.stdev>0))throw new Error(Je.NO_FEATURE_VARIATION);this.setStats(t,e,n)}areVarsEqual(t){const e=this.catCount;if(1===e)return!0;const n={sum:this.sums[0],sumOfSquares:this.sumsOfSquares[0],size:this.subSampleSizes[0]};for(let o=1;o<e;++o)if(!on(n,{sum:this.sums[o],sumOfSquares:this.sumsOfSquares[o],size:this.subSampleSizes[o]},t))return!1;return!0}getOneWayAnova(){let t=0,e=0,n=0,o=this.catCount,r=o;for(let i=0;i<o;++i)0!==this.subSampleSizes[i]?(t+=this.sums[i],e+=this.sumsOfSquares[i],n+=Math.pow(this.sums[i],2)/this.subSampleSizes[i]):--r;if(o=r,1===o)throw new Error(Je.SINGLE_FACTOR);const i=this.size-this.nullsCount;if(i===o)throw new Error(Je.CATS_EQUAL_SIZE);const s=e-Math.pow(t,2)/i,a=n-Math.pow(t,2)/i,l=s-a;if(0===l)throw new Error(Je.NO_FEATURE_VARIATION_WITHIN_GROUPS);const u=o-1,c=i-o,f=a/u,d=l/c,h=f/d;return{ssBn:a,ssWn:l,ssTot:s,dfBn:u,dfWn:c,dfTot:i-1,msBn:f,msWn:d,fStat:h,pValue:1-tn.centralF.cdf(h,u,c)}}setStats(e,n,o){const r=n.type,i=n.length,s=je(n);switch(r){case t.COLUMN_TYPE.INT:case t.COLUMN_TYPE.FLOAT:const r=o;this.catCount=r,this.size=i;const a=n.getRawData(),l=e.getRawData(),u=new Float64Array(r).fill(0),c=new Float64Array(r).fill(0),f=new Int32Array(r).fill(0);let d;if(e.type==t.COLUMN_TYPE.BOOL){let t=0,e=0,n=l[0];const o=8*l.BYTES_PER_ELEMENT-1;for(let r=0;r<i;++r)d=1&n>>e,a[r]!==s?(u[d]+=a[r],c[d]+=Math.pow(a[r],2),++f[d]):++this.nullsCount,++e,e>o&&(e=0,++t,n=l[t])}else{const t=e.stats.missingValueCount>0?je(e):-1;for(let e=0;e<i;++e)d=l[e],d!==t&&a[e]!==s?(u[d]+=a[e],c[d]+=Math.pow(a[e],2),++f[d]):++this.nullsCount}this.sums=u,this.sumsOfSquares=c,this.subSampleSizes=f;break;default:throw new Error(Je.UNSUPPORTED_COLUMN_TYPE)}}}function sn(t,e,n,o=!0){en(n);const r=t.stats.uniqueCount;if(r<2)throw new Error(Je.SINGLE_FACTOR);const i=new rn(t,e,r);if(o&&!i.areVarsEqual(n))throw new Error(Je.NON_EQUAL_VARIANCES);const s=i.getOneWayAnova();return{anovaTable:s,fCritical:tn.centralF.inv(1-n,s.dfBn,s.dfWn),significance:n}}var an=function(t,e,n,o){return new(n||(n=Promise))(function(r,i){function s(t){try{l(o.next(t))}catch(t){i(t)}}function a(t){try{l(o.throw(t))}catch(t){i(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n(function(t){t(e)})).then(s,a)}l((o=o.apply(t,e||[])).next())})};const ln=.05,un=!1,cn=t.Column.fromList(t.COLUMN_TYPE.INT,"features",[9,12,4,8,7,4,6,8,2,10,1,3,4,5,2]),fn=t.Column.fromStrings("features",["A","A","A","A","A","B","B","B","B","B","C","C","C","C","C"]);var dn;!function(t){t[t.DF_BN=2]="DF_BN",t[t.DF_TOT=14]="DF_TOT",t[t.DF_WN=12]="DF_WN",t[t.SS_BN=63.333]="SS_BN",t[t.SS_TOT=147.333]="SS_TOT",t[t.SS_WN=84]="SS_WN",t[t.MS_BN=31.666]="MS_BN",t[t.MS_WN=7]="MS_WN",t[t.F_STAT=4.523]="F_STAT",t[t.F_CRIT=3.885]="F_CRIT",t[t.P_VAL=.034]="P_VAL"}(dn||(dn={})),b("ANOVA",()=>{C("Performance: 1M rows demog",()=>an(void 0,void 0,void 0,function*(){const t=I.data.demo.demog(1e6),e=t.col("race"),n=t.col("height");new rn(e,n,e.stats.uniqueCount).areVarsEqual(ln),sn(e,n,ln,un)}),{timeout:4e3,benchmark:!0}),C("Correctness",()=>an(void 0,void 0,void 0,function*(){const t=sn(fn,cn,ln,un),e=t.anovaTable;E(e.dfBn,dn.DF_BN,"Incorrect degrees of freedom: dfBn"),E(e.dfTot,dn.DF_TOT,"Incorrect degrees of freedom: dfTot"),E(e.dfWn,dn.DF_WN,"Incorrect degrees of freedom: dfWn");const n=(t,e)=>Math.abs(t-e)<.01;E(n(e.ssBn,dn.SS_BN),!0,"Incorrect sum of squares: ssBn"),E(n(e.ssTot,dn.SS_TOT),!0,"Incorrect sum of squares: ssTot"),E(n(e.ssWn,dn.SS_WN),!0,"Incorrect sum of squares: ssWn"),E(n(e.msBn,dn.MS_BN),!0,"Incorrect mean squares: msBn"),E(n(e.msWn,dn.MS_WN),!0,"Incorrect mean squares: msWn"),E(n(e.fStat,dn.F_STAT),!0,"Incorrect F-statistics value"),E(n(e.pValue,dn.P_VAL),!0,"Incorrect p-value"),E(n(t.fCritical,dn.F_CRIT),!0,"Incorrect F-critical")}),{timeout:4e3})});const hn=rxjs;function mn(t){return"numerical"===t.functionType}function pn(t=1,e=0,n=1){return{functionType:"numerical",weight:t,mode:"freeform",min:e,max:n,line:[]}}function gn(t=1,e){return{functionType:"categorical",weight:t,categories:null!=e?e:[{name:"Category 1",desirability:1}]}}function vn(t){return t.functionType?t:t.categories?{...t,functionType:"categorical"}:{...t,functionType:"numerical"}}const yn=["Average","Sum","Product","Geomean","Min","Max"],An="Average";class wn{constructor(t,e=!1,n=!1){this.onChanged=new hn.Subject,this.supportsModeDialog=!0,this.desirabilityInputs=[],this.form=null,this.columnCategories=null,this._prop=t,this.design=e,this.showControls=n,this.root=ot.divV([],"statistics-mpo-cat-editor"),this.buildForm()}buildForm(){var t;const e=null!==(t=this._prop.categories)&&void 0!==t?t:[];this.form&&(ot.empty(this.root),this.form=null,this.desirabilityInputs=[]),this.design?this.buildDesignForm(e):this.buildViewForm(e)}createDesirabilityInput(t,e){var n;const o=ot.input.float(t,{value:null!==(n=e.desirability)&&void 0!==n?n:.5,min:0,max:1,format:"#0.000",onValueChanged:t=>{e.desirability=t,this.onChanged.next(this._prop)}});return this.desirabilityInputs.push(o),o}buildViewForm(t){for(const e of t)this.createDesirabilityInput(e.name,e);this.form=ot.form(this.desirabilityInputs),this.root.append(this.form)}buildDesignForm(t){const e=ot.divH([ot.divText("Name","statistics-mpo-cat-col-header statistics-mpo-cat-name"),ot.divText("Score","statistics-mpo-cat-col-header statistics-mpo-cat-desirability"),...this.showControls?[ot.div([],{style:{width:"40px"}})]:[]],"statistics-mpo-cat-row statistics-mpo-cat-header-row"),n=t.map((t,e)=>this.buildCategoryRow(t,e));this.form=ot.divV([e,...n]),this.root.append(this.form)}buildCategoryRow(t,e){const n=this.columnCategories?ot.input.choice("",{items:this.columnCategories,nullable:!0,value:t.name||null,onValueChanged:e=>{t.name=null!=e?e:"",this.onChanged.next(this._prop)}}):ot.input.string("",{value:t.name,onValueChanged:e=>{t.name=e,this.onChanged.next(this._prop)}});n.root.classList.add("statistics-mpo-cat-name");const o=this.createDesirabilityInput("",t);o.root.classList.add("statistics-mpo-cat-desirability");const r=[n.root,o.root];if(this.showControls){const t=ot.icons.add(()=>{const t={name:this.columnCategories?"":`Category ${this._prop.categories.length+1}`,desirability:1};this._prop.categories.splice(e+1,0,t),this.buildForm(),this.onChanged.next(this._prop)}),n=ot.icons.delete(()=>{this._prop.categories.splice(e,1),this.buildForm(),this.onChanged.next(this._prop)});r.push(ot.divH([t,n],"statistics-mpo-control-buttons"))}return ot.divH(r,"statistics-mpo-cat-row")}redrawAll(t=!0){this.buildForm(),t&&this.onChanged.next(this._prop)}setChoices(t){this.columnCategories=t,this.buildForm()}setColumn(t){var e,n;if(!t)return;this.columnCategories=t.isCategorical?[...t.categories]:null;const o=new Map(null!==(n=null===(e=this._prop.categories)||void 0===e?void 0:e.map(t=>[t.name,t.desirability]))&&void 0!==n?n:[]);this._prop.categories=t.categories.map(t=>{var e;return{name:t,desirability:null!==(e=o.get(t))&&void 0!==e?e:1}}),this.buildForm()}}let Cn;const En=10,bn=10,xn=20,_n=30,Nn={line:t.Color.toHtml(t.Color.filteredRows),handle:t.Color.toHtml(t.Color.selectedRows),barFill:t.Color.toHtml(t.Color.histogramBar),barStroke:t.Color.toHtml(t.Color.lightGray)};class Mn{constructor(t,e,n,o){this.minX=t,this.maxX=e,this.width=n,this.height=o,this.plotWidth=n-_n-bn,this.plotHeight=o-En-xn,this.scaleX=this.maxX-this.minX===0?1:this.plotWidth/(this.maxX-this.minX),this.scaleY=this.plotHeight}toCanvasCoords(t){return{x:_n+(t[0]-this.minX)*this.scaleX,y:En+this.plotHeight-t[1]*this.scaleY}}toDataCoords(t,e){let n=this.minX+(t-_n)/this.scaleX,o=(En+this.plotHeight-e)/this.scaleY;return n=Math.max(this.minX,Math.min(this.maxX,n)),o=Math.max(0,Math.min(1,o)),{x:n,y:o}}}class Tn{constructor(t,e,n){this.root=ot.div(),this.onChanged=new hn.Subject,this.supportsModeDialog=!0,this.ignoreNextClick=!1,this.dragScaleX=0,this.dragScaleY=0,this._prop=t,this._width=e,this._height=n,this.ensureDefaultLine(),this.root.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.position="relative",requestAnimationFrame(()=>this.initKonva(e,n))}ensureDefaultLine(){var t,e;if(this._prop.line.length>0)return;const n=null!==(t=this._prop.min)&&void 0!==t?t:0,o=null!==(e=this._prop.max)&&void 0!==e?e:1;this._prop.line=[[n,.5],[o,.5]]}updateDragScales(){const t=this._width-_n-bn,e=this._height-En-xn;this.dragScaleX=(this.getMaxX()-this.getMinX())/t,this.dragScaleY=1/e}isInPlotArea(t,e,n){return t.x>=_n&&t.x<=e-bn&&t.y>=En&&t.y<=n-xn}async initKonva(t,e){var n;if(!this.root.parentElement)return void console.warn("Konva container not attached to DOM yet.");const o=await async function(){return Cn||(Cn=(await s.e(397).then(s.t.bind(s,5778,23))).default),Cn}();this.barsLayer=new o.Layer,this.stage=new o.Stage({container:this.root,width:t,height:e}),this.stage.add(this.barsLayer),this.layer=new o.Layer,this.stage.add(this.layer);const r=this.getMinX(),i=this.getMaxX();this.drawAxes(r,i,t,e),this.konvaLine=new o.Line({points:[],stroke:Nn.line,strokeWidth:2,lineCap:"round",lineJoin:"round"}),this.layer.add(this.konvaLine),this.pointsGroup=new o.Group,this.layer.add(this.pointsGroup),this.redrawFn=(n=!0)=>{const r=this.getMinX(),i=this.getMaxX();"freeform"===this._prop.mode&&this._prop.freeformLine&&(this._prop.line=this._prop.freeformLine),"freeform"!==this._prop.mode&&(this._prop.freeformLine||(this._prop.freeformLine=[...this._prop.line]),this._prop.line=this.computeLine()),this.pointsGroup.destroyChildren();const s=[],a=new Mn(r,i,t,e),l=[...this._prop.line.keys()].sort((t,e)=>this._prop.line[t][0]-this._prop.line[e][0]);l.map(t=>this._prop.line[t]).forEach((t,n)=>{const u=a.toCanvasCoords([t[0],t[1]]);if(s.push(u.x,u.y),"freeform"!==this._prop.mode)return;const c=new o.Circle({x:u.x,y:u.y,radius:3,fill:"white",stroke:Nn.line,strokeWidth:1,draggable:!0,hitStrokeWidth:5});c.setAttr("_dataIndex",l[n]),c.on("dragmove",t=>{const n=t.target,o=n.position(),s=n.getAttr("_dataIndex"),u=l.indexOf(s),c=u>0?this._prop.line[l[u-1]][0]:r,f=u<l.length-1?this._prop.line[l[u+1]][0]:i,d=i-r===0?0:.001*(i-r),h=a.toCanvasCoords([c+(u>0?d:0),0]).x,m=a.toCanvasCoords([f-(u<l.length-1?d:0),0]).x;o.x=Math.max(h,Math.min(m,o.x));const p=e-xn;o.y=Math.max(10,Math.min(p,o.y)),n.position(o);const g=a.toDataCoords(o.x,o.y);this._prop.line[s][0]=g.x,this._prop.line[s][1]=g.y;const v=this._prop.line.map((t,e)=>{if(e===s)return[o.x,o.y];{const e=a.toCanvasCoords([t[0],t[1]]);return[e.x,e.y]}}).flat();this.konvaLine.points(v),this.layer.batchDraw()}),c.on("dragend",()=>{var t;this._prop.line.sort((t,e)=>t[0]-e[0]),null===(t=this.redrawFn)||void 0===t||t.call(this)}),c.on("contextmenu",t=>{var e;if(t.evt.preventDefault(),this._prop.line.length<=2)return void I.shell.warning("Cannot remove points, minimum of 2 required.");this.ignoreNextClick=!0;const n=t.target.getAttr("_dataIndex");n>=0&&(null==this._prop.min&&(this._prop.min=this.getMinX()),null==this._prop.max&&(this._prop.max=this.getMaxX()),this._prop.line.splice(n,1),null===(e=this.redrawFn)||void 0===e||e.call(this))}),c.on("mouseenter",t=>{this.stage.container().style.cursor="pointer";const e=t.target.position(),n=a.toDataCoords(e.x,e.y),o=`X: ${n.x.toFixed(2)}, Y: ${n.y.toFixed(2)}<br><br>Drag to move, double-click to edit, right-click to delete`;ot.tooltip.show(o,t.evt.clientX,t.evt.clientY)}),c.on("mouseleave",()=>{this.stage.container().style.cursor="default",ot.tooltip.hide()}),c.on("dblclick dbltap",t=>{this.ignoreNextClick=!0,ot.tooltip.hide();const e=t.target.getAttr("_dataIndex");this.showPointEditor(e,t.evt.clientX,t.evt.clientY)}),this.pointsGroup.add(c)}),this.konvaLine.points(s),this.layer.batchDraw(),this.addSpecialHandle(t,e),n&&this.onChanged.next(this._prop.line)},this.stage.on("click tap",t=>{var e,n;if(this.ignoreNextClick)return void(this.ignoreNextClick=!1);if(t.target instanceof o.Circle||0!==t.evt.button)return;const r=null===(e=this.stage)||void 0===e?void 0:e.getPointerPosition();if(!r)return;const i=this.getMinX(),s=this.getMaxX();if(!this.isInPlotArea(r,this.stage.width(),this.stage.height()))return;const a=new Mn(i,s,this.stage.width(),this.stage.height()).toDataCoords(r.x,r.y);this._prop.line.push([a.x,a.y]),this._prop.line.sort((t,e)=>t[0]-e[0]),null===(n=this.redrawFn)||void 0===n||n.call(this)}),this.stage.on("mousemove",n=>{if(!this.stage)return;const o=this.stage.getPointerPosition();o&&"freeform"!==this._prop.mode&&(this.isInPlotArea(o,t,e)?this.stage.container().style.cursor="grab":this.stage.container().style.cursor="default")}),this.stage.on("mouseout",()=>ot.tooltip.hide()),this.enableCurveDrag(t,e),this.updateDragScales(),this.pendingBarValues&&(this.drawBars(this.pendingBarValues),this.pendingBarValues=void 0),null===(n=this.redrawFn)||void 0===n||n.call(this,!1)}get line(){return this._prop.line}computeLine(){var t,e,n,o,r,i,s,a;if("freeform"===this._prop.mode)return this._prop.line;const l=this.getMinX(),u=this.getMaxX(),c=[];for(let f=0;f<=60;f++){const d=l+f/60*(u-l);let h=0;if("gaussian"===this._prop.mode){null!==(t=(r=this._prop).mean)&&void 0!==t||(r.mean=(l+u)/2),null!==(e=(i=this._prop).sigma)&&void 0!==e||(i.sigma=(u-l)/6);const n=(d-this._prop.mean)/this._prop.sigma;h=Math.exp(-.5*n*n)}if("sigmoid"===this._prop.mode){null!==(n=(s=this._prop).x0)&&void 0!==n||(s.x0=(l+u)/2),null!==(o=(a=this._prop).k)&&void 0!==o||(a.k=10);const t=this._prop.x0,e=this._prop.k;h=1/(1+Math.exp(-e*(d-t)))}c.push([d,h])}return c}drawAxes(t,e,n,o){const r=getComputedStyle(document.documentElement).getPropertyValue("--grey-2").trim()||"#DBDCDF";this.layer.add(new Cn.Line({points:[_n,o-xn,n-bn,o-xn],stroke:r,strokeWidth:1}),new Cn.Line({points:[_n,En,_n,o-xn],stroke:r,strokeWidth:1}),new Cn.Text({x:_n,y:o-xn+3,text:t.toFixed(1),fontSize:9,fill:"grey"}),new Cn.Text({x:n-bn-15,y:o-xn+3,text:e.toFixed(1),fontSize:9,fill:"grey"}))}getMinX(){var t,e;return null!==(e=null!==(t=this._prop.min)&&void 0!==t?t:Math.min(...this._prop.line.map(t=>t[0])))&&void 0!==e?e:0}getMaxX(){var t,e;return null!==(e=null!==(t=this._prop.max)&&void 0!==t?t:Math.max(...this._prop.line.map(t=>t[0])))&&void 0!==e?e:1}getDefaultMean(){return(this.getMinX()+this.getMaxX())/2}getDefaultSigma(){return Math.max(.01,(this.getMaxX()-this.getMinX())/6)}getDefaultX0(){return(this.getMinX()+this.getMaxX())/2}getDefaultK(){return 10}redrawAll(t=!0){if(!this.stage||!this.layer||!this.redrawFn)return;const e=this.stage.width(),n=this.stage.height(),o=this.getMinX(),r=this.getMaxX();this.layer.destroyChildren(),this.drawAxes(o,r,e,n),this.layer.add(this.konvaLine,this.pointsGroup),this.redrawFn(t),this.barValues&&this.drawBars()}drawBars(t){var e;if(t&&(this.barValues=t),!this.barsLayer)return void(this.pendingBarValues=t);if(this.barsLayer.destroyChildren(),!this.barValues||0===this.barValues.length)return;const n=this.barsLayer.getStage();if(!n)return void(this.pendingBarValues=t);const o=n.width(),r=n.height(),i=this.getMinX(),s=this.getMaxX();if(s===i)return;const a=o-_n-bn,l=r-En-xn,u=Math.max(1e-9,(s-i)/20),c=new Array(20).fill(0);(null!==(e=this.barValues)&&void 0!==e?e:[]).forEach(t=>{const e=Math.min(Math.floor((t-i)/u),19);c[e]++});const f=Math.max(...c)||1;c.forEach((t,e)=>{const n=_n+e*u/(s-i)*a,o=u/(s-i)*a-1,r=t/f*l,c=new Cn.Rect({x:n,y:En+l-r,width:o,height:r,fill:Nn.barFill,opacity:.25,stroke:Nn.barStroke,strokeWidth:.5});this.barsLayer.add(c)}),this.barsLayer.batchDraw()}enableCurveDrag(t,e){if(!this.stage)return;let n=!1,o=null,r=0,i=0,s=0,a=0;this.stage.on("mousedown touchstart",l=>{var u,c,f,d;if("freeform"===this._prop.mode)return;if(!l.evt)return;const h=this.stage.getPointerPosition();h&&this.isInPlotArea(h,t,e)&&(n=!0,o=h,r=null!==(u=this._prop.mean)&&void 0!==u?u:(this.getMinX()+this.getMaxX())/2,i=null!==(c=this._prop.sigma)&&void 0!==c?c:(this.getMaxX()-this.getMinX())/6,s=null!==(f=this._prop.x0)&&void 0!==f?f:(this.getMinX()+this.getMaxX())/2,a=null!==(d=this._prop.k)&&void 0!==d?d:10,this.stage.container().style.cursor="grabbing")}),this.stage.on("mousemove touchmove",t=>{var e,l;if(!n||!o)return;const u=this.stage.getPointerPosition();if(!u)return;const c=u.x-o.x,f=u.y-o.y;"gaussian"===this._prop.mode&&(this._prop.mean=r+c*this.dragScaleX,this._prop.sigma=Math.max(.01,i+-f*this.dragScaleY*(this.getMaxX()-this.getMinX()))),"sigmoid"===this._prop.mode&&(this._prop.x0=s+c*this.dragScaleX,this._prop.k=Math.max(.1,a+-f*this.dragScaleY*50)),this._prop.line=this.computeLine(),null===(e=this.redrawFn)||void 0===e||e.call(this),null===(l=this.onParamsChanged)||void 0===l||l.call(this,this._prop)}),this.stage.on("mouseup touchend",()=>{n=!1,o=null,this.stage.container().style.cursor="default"})}addSpecialHandle(t,e){var n,o;if("freeform"===this._prop.mode)return;const r=this.getMinX(),i=this.getMaxX(),s=new Mn(r,i,t,e);let a=(r+i)/2,l=.5;"gaussian"===this._prop.mode?(a=null!==(n=this._prop.mean)&&void 0!==n?n:(r+i)/2,l=1):"sigmoid"===this._prop.mode&&(a=null!==(o=this._prop.x0)&&void 0!==o?o:(r+i)/2,l=.5);const u=s.toCanvasCoords([a,l]);this.specialHandle?(this.specialHandle.getLayer()||this.layer.add(this.specialHandle),this.specialHandle.position(u)):(this.specialHandle=new Cn.Circle({x:u.x,y:u.y,radius:7,fill:Nn.handle,draggable:!0,hitStrokeWidth:15}),this.specialHandle.on("dragmove",t=>{var e,n;const o=t.target.position(),r=s.toDataCoords(o.x,o.y);var i;"gaussian"===this._prop.mode?(this._prop.mean=r.x,this._prop.sigma=Math.max(.01,Math.abs(r.y-1))):"sigmoid"===this._prop.mode&&(this._prop.x0=r.x,this._prop.k=(i=30*Math.abs(r.y-.5),Math.max(.1,Math.min(30,i)))),this._prop.line=this.computeLine(),null===(e=this.redrawFn)||void 0===e||e.call(this),null===(n=this.onParamsChanged)||void 0===n||n.call(this,this._prop)}),this.layer.add(this.specialHandle)),this.layer.batchDraw()}showPointEditor(t,e,n){const o=this._prop.line[t],r=ot.input.float("X",{value:o[0],min:this.getMinX(),max:this.getMaxX(),format:"#0.00",step:.01}),i=ot.input.float("Y",{value:o[1],min:0,max:1,format:"#0.00",step:.01}),s=()=>{u.removeEventListener("keydown",l),f.remove()},a=()=>{const e=r.value,n=i.value;null==e||null==n||isNaN(e)||isNaN(n)||(this._prop.line[t]=[e,n],this.redrawAll())},l=t=>{"Enter"===t.key&&(a(),s()),"Escape"===t.key&&s()},u=ot.inputs([r,i]);u.style.overflow="hidden",u.addEventListener("keydown",l);const c=this.root.getBoundingClientRect(),f=ot.showPopup(u,this.root,{dx:e-c.left,dy:n-c.bottom,smart:!1})}setRange(t,e){const n=this.getMinX(),o=this.getMaxX()-n,r=e-t;if(0!==o&&0!==r){const e=r/o,i=o=>t+(o-n)*e;null!=this._prop.mean&&(this._prop.mean=i(this._prop.mean)),null!=this._prop.sigma&&(this._prop.sigma*=e),null!=this._prop.x0&&(this._prop.x0=i(this._prop.x0)),null!=this._prop.k&&(this._prop.k/=e);for(const t of this._prop.line)t[0]=i(t[0]);if(this._prop.freeformLine)for(const t of this._prop.freeformLine)t[0]=i(t[0])}this._prop.min=t,this._prop.max=e,this.updateDragScales(),this.redrawAll(!1)}setColumn(t){if(!t)return;const e=t.toList();this.drawBars(e)}}class Sn{static create(t,e=300,n=80,o=!1){return mn(t)?new Tn(t,e,n):new wn(t,o,!1)}}const On=["freeform","gaussian","sigmoid"],In=["numerical","categorical"];function Ln(t){return ot.divText(t,"statistics-mpo-section-header")}class Pn{constructor(t,e,n,o,r){this.propertyName=t,this.prop=e,this.onUpdate=n,this.onTypeChanged=o,this.mappedCol=r}static strategyToLabel(t){switch(t){case"default":return"Use default score";case"skip":return"Skip property";default:return"Exclude row"}}buildDefaultScoreInput(t){const e=t.missingValues,n=ot.input.float("Default score",{value:"default"===(null==e?void 0:e.strategy)?e.score:0,min:0,max:1,format:"#0.000",onValueChanged:e=>{t.missingValues={strategy:"default",score:e},this.onUpdate({missingValues:t.missingValues})}});n.root.style.display="default"===(null==e?void 0:e.strategy)?"":"none";const o=ot.input.choice("If missing",{items:["Exclude row","Use default score","Skip property"],value:Pn.strategyToLabel(null==e?void 0:e.strategy),onValueChanged:e=>{var o;const r="Use default score"===e;t.missingValues="Skip property"===e?{strategy:"skip"}:r?{strategy:"default",score:null!==(o=n.value)&&void 0!==o?o:0}:{strategy:"exclude"},n.root.style.display=r?"":"none",this.onUpdate({missingValues:t.missingValues})}});return o.setTooltip("How to handle missing values:<br>• <b>Exclude row</b> — assign an MPO score of 0 to the row<br>• <b>Use default score</b> — use a fixed fallback desirability value<br>• <b>Skip property</b> — calculate the score from the remaining properties"),n.setTooltip("Desirability score (0–1) to use as fallback."),ot.form([o,n])}show(){const t=structuredClone(this.prop),e=ot.dialog({title:this.propertyName});e.root.classList.add("statistics-mpo-desirability-dialog");const n=ot.divV([]),o={[t.functionType]:structuredClone(t)},r=[];let i;const s=ot.input.choice("Type",{items:[...In],value:this.prop.functionType,onValueChanged:e=>{var n;if(e!==this.prop.functionType){if(o[this.prop.functionType]=structuredClone(this.prop),o[e])this.prop=structuredClone(o[e]);else if("categorical"===e){const e=(null===(n=this.mappedCol)||void 0===n?void 0:n.isCategorical)?this.mappedCol.categories.map(t=>({name:t,desirability:1})):void 0;this.prop=gn(t.weight,e)}else this.prop=pn(t.weight);c()}}}),a=()=>{var t,e,o;const s=this.prop;null!==(t=s.mode)&&void 0!==t||(s.mode="freeform");const a=new Tn(s,355,103);(null===(e=this.mappedCol)||void 0===e?void 0:e.isNumerical)&&a.setColumn(this.mappedCol);const l=ot.input.choice("Mode",{items:On,value:s.mode,onValueChanged:t=>{s.mode=t,this.onUpdate({mode:s.mode}),d(),a.redrawAll(!1)}}),u=[{key:"min",label:"Min",fallback:()=>a.getMinX()},{key:"max",label:"Max",fallback:()=>a.getMaxX()},{key:"mean",label:"Mean",fallback:()=>a.getDefaultMean()},{key:"sigma",label:"Sigma",fallback:()=>a.getDefaultSigma(),transform:t=>Math.max(.01,t)},{key:"x0",label:"x0",fallback:()=>a.getDefaultX0()},{key:"k",label:"k",fallback:()=>a.getDefaultK(),transform:t=>Math.max(.1,t)}],c=new Map;for(const t of u)c.set(t.key,ot.input.float(t.label,{value:null!==(o=s[t.key])&&void 0!==o?o:t.fallback(),format:"#0.000",onValueChanged:e=>{const n=t.transform?t.transform(null!=e?e:t.fallback()):null!=e?e:t.fallback();s[t.key]=n,this.onUpdate({[t.key]:n}),a.redrawAll(!1)}}));c.get("min").setTooltip("Minimum property value"),c.get("max").setTooltip("Maximum property value");const f=ot.form([c.get("min"),c.get("max"),c.get("mean"),c.get("sigma"),c.get("x0"),c.get("k")]);f.classList.add("statistics-mpo-param-grid");const d=()=>{c.get("mean").root.classList.toggle("statistics-mpo-hidden","gaussian"!==s.mode),c.get("sigma").root.classList.toggle("statistics-mpo-hidden","gaussian"!==s.mode),c.get("x0").root.classList.toggle("statistics-mpo-hidden","sigmoid"!==s.mode),c.get("k").root.classList.toggle("statistics-mpo-hidden","sigmoid"!==s.mode)};d(),a.onParamsChanged=t=>{Object.assign(s,t),(()=>{var t;for(const e of u)c.get(e.key).value=null!==(t=s[e.key])&&void 0!==t?t:e.fallback()})(),this.onUpdate(t)},r.push(a.onChanged.subscribe(t=>{s.line=t,"freeform"===s.mode&&this.onUpdate({line:t})})),i=l.root,a.root.classList.add("statistics-mpo-plot"),n.append(a.root,Ln("PARAMETERS"),f)},l=()=>{var t;const e=this.prop,o=new wn(e,!0,!0);(null===(t=this.mappedCol)||void 0===t?void 0:t.isCategorical)&&o.setChoices([...this.mappedCol.categories]),r.push(o.onChanged.subscribe(()=>this.onUpdate(this.prop))),n.append(Ln("CATEGORIES"),o.root)},u=()=>{for(const t of r)t.unsubscribe();r.length=0},c=()=>{u(),ot.empty(n),i=void 0,mn(this.prop)?a():l();const t=[];this.mappedCol||t.push(s.root),i&&t.push(i),t.length>0&&n.prepend(ot.divH(t,"statistics-mpo-dialog-header-row")),n.append(Ln("MISSING VALUES"),this.buildDefaultScoreInput(this.prop))};c(),e.add(n),e.onOK(()=>{var n;u(),this.prop.functionType!==t.functionType?null===(n=this.onTypeChanged)||void 0===n||n.call(this,this.prop):this.onUpdate(this.prop),e.close()}),e.onCancel(()=>{u(),this.prop=t,this.onUpdate(t),e.close()}),e.show()}}var Rn=s(5072),Fn=s.n(Rn),Dn=s(7825),Bn=s.n(Dn),kn=s(7659),Un=s.n(kn),Vn=s(5056),Gn=s.n(Vn),$n=s(540),Hn=s.n($n),qn=s(1113),Yn=s.n(qn),Wn=s(6801),jn={};jn.styleTagTransform=Yn(),jn.setAttributes=Gn(),jn.insert=Un().bind(null,"head"),jn.domAPI=Bn(),jn.insertStyleElement=Hn(),Fn()(Wn.A,jn),Wn.A&&Wn.A.locals&&Wn.A.locals;class Xn{constructor(t,e=!1,n=!1){this.root=ot.div([]),this.onChanged=new hn.Subject,this.design=!1,this.preview=!1,this.rows={},this.rowIds={},this.rowSubs=new Map,this.propertyOrder=[],this.columnMapping={},this.dataFrame=t,this.design=e,this.preview=n,this.aggregationInput=ot.input.choice("Aggregation",{items:yn,value:An,nullable:!1,onValueChanged:t=>{this.profile&&(this.profile.aggregation=t),this.emitChange()}}),this.aggregationInput.setTooltip("Score aggregation method")}newRowId(){return crypto.randomUUID()}setProfile(t){var e,n;if(t)for(const n of Object.keys(t.properties)){const o=vn(t.properties[n]);mn(o)&&(null!==(e=o.mode)&&void 0!==e||(o.mode="freeform")),t.properties[n]=o}for(const t of this.rowSubs.values())t.unsubscribe();this.rowSubs.clear(),this.profile=t,this.aggregationInput.value=null!==(n=null==t?void 0:t.aggregation)&&void 0!==n?n:An,this.columnMapping={},this.rows={},this.rowIds={},this.propertyOrder=t?Object.keys(t.properties):[];for(const t of this.propertyOrder)this.rowIds[t]=this.newRowId();this.render()}getProfile(){return this.profile}setDesignMode(t){this.design!==t&&(this.design=t,this.rows={},this.render())}setPreviewMode(t){this.preview!==t&&(this.preview=t,this.rows={},this.render())}render(){if(ot.empty(this.root),!this.profile)return this.renderEmpty("No profile specified.");const t=this.propertyOrder.map(t=>{const e=this.rowIds[t];return this.rows[e]||(this.rows[e]=this.buildRow(t,e,this.profile.properties[t])),this.rows[e]});if(!t.length)return this.preview||this.root.append(this.buildHeader()),this.design?this.renderDesignEmpty():this.renderEmpty("No properties defined.");this.preview||this.root.append(this.buildHeader()),this.root.append(ot.divV(t))}renderEmpty(t){this.root.append(ot.divText(t))}renderDesignEmpty(){const t=ot.iconFA("chart-line"),e=ot.h3("No properties yet"),n=ot.p("Select a dataset to auto-populate properties from its numerical columns, or add them manually."),o=ot.link("+ Add Property",()=>this.addProperty()),r=ot.divV([t,e,n,o],"statistics-mpo-empty-state");this.root.append(r)}addProperty(){if(!this.profile)return;const t=`NewProperty${Object.keys(this.profile.properties).length+1}`,e=this.newRowId();this.profile.properties[t]=pn(),this.rowIds[t]=e,this.propertyOrder.push(t),this.rows={},this.render(),this.emitChange()}buildHeader(){return ot.divH([ot.divText("Property","statistics-mpo-header-property"),ot.divText("Weight","statistics-mpo-header-weight"),ot.divText("Desirability","statistics-mpo-header-desirability")],"statistics-mpo-header")}buildRow(t,e,n){var o;const r=ot.divH([],"statistics-mpo-row");r.dataset.rowId=e;const i=this.resolveColumn(t);if(i){const e=this.correctPropertyType(n,i);e&&(n=e,this.profile.properties[t]=n)}const s=Sn.create(n,300,80,this.design);null===(o=this.rowSubs.get(e))||void 0===o||o.unsubscribe(),this.rowSubs.set(e,s.onChanged.subscribe(()=>this.emitChange()));const a=this.buildPropertyCell(e,t),l=this.buildWeightCell(e,n),u=this.buildColumnSelector(e,t,s),c=this.design?this.buildModeGear(e,n,s):null,f=this.design?this.buildRowControls(e):null;return r.append(ot.divV([a,u].filter(Boolean),"statistics-mpo-property-cell"),l,ot.divH([s.root,c].filter(Boolean))),f&&r.append(f),r}buildPropertyCell(t,e){if(this.dataFrame){const t=ot.divText(e);return ot.tooltip.bind(t,()=>e),t}let n=e;const o=ot.input.string("",{value:e,onValueChanged:t=>{t&&t!==n&&(this.renameProperty(n,t),n=t)}});return ot.tooltip.bind(o.input,()=>n),o.root}buildWeightCell(t,e){var n;const o=this.getPropertyNameByRowId(t),r=[],i=ot.input.float("",{value:e.weight,min:0,max:1,format:"#0.000",onValueChanged:t=>{o&&this.mutateProperty(o,e=>e.weight=Math.max(0,Math.min(1,null!=t?t:0)))}});if(i.root.classList.add("statistics-mpo-weight-input"),r.push(i.root),this.dataFrame){const t=this.getNumericalColumnNames();let s=!!e.weightColumn&&t.includes(e.weightColumn);const a=ot.input.choice("",{items:t,nullable:!0,value:null!==(n=e.weightColumn)&&void 0!==n?n:"",onValueChanged:t=>{o&&this.mutateProperty(o,e=>e.weightColumn=t||void 0)}}),l=()=>{i.root.classList.toggle("statistics-mpo-hidden",s),a.root.classList.toggle("statistics-mpo-hidden",!s),u.classList.toggle("statistics-mpo-weight-toggle-active",s)},u=ot.iconFA("columns",()=>{s=!s,l(),!s&&o?this.mutateProperty(o,t=>{delete t.weightColumn}):s&&o&&a.value&&this.mutateProperty(o,t=>t.weightColumn=a.value||void 0)});u.classList.add("statistics-mpo-weight-toggle"),ot.tooltip.bind(u,()=>s?"Switch to manual weight":"Use weight from column"),l(),r.push(a.root,u)}return ot.divH(r,"statistics-mpo-weight-cell")}buildColumnSelector(t,e,n){var o,r;if(!this.dataFrame)return null;const i=this.getEligibleColumnNames(),s=null!==(o=this.columnMapping[e])&&void 0!==o?o:null;if(s){const t=this.dataFrame.col(s);null===(r=n.setColumn)||void 0===r||r.call(n,t)}const a=ot.input.choice("",{items:i,nullable:!0,value:null!=s?s:"",onValueChanged:o=>{var r;this.columnMapping[e]=null!=o?o:null;const i=o?this.dataFrame.col(o):null;i&&this.switchPropertyType(e,t,i)||(null===(r=n.setColumn)||void 0===r||r.call(n,i),this.emitChange())}});return a.root}getEligibleColumnNames(){return this.dataFrame?Array.from(this.dataFrame.columns).filter(t=>!t.isCategorical||t.categories.length<=20).map(t=>t.name):[]}getNumericalColumnNames(){return this.dataFrame?Array.from(this.dataFrame.columns.numerical).map(t=>t.name):[]}resolveColumn(t){var e,n,o;if(!this.dataFrame)return null;const r=this.getEligibleColumnNames(),i=null!==(n=null!==(e=this.columnMapping[t])&&void 0!==e?e:r.find(e=>e.toLowerCase()===t.toLowerCase()))&&void 0!==n?n:null;return i&&(this.columnMapping[t]=i),i&&null!==(o=this.dataFrame.col(i))&&void 0!==o?o:null}correctPropertyType(t,e){if(mn(t)&&e.isCategorical){const n=e.categories.map(t=>({name:t,desirability:1}));return gn(t.weight,n)}return!mn(t)&&e.isNumerical?pn(t.weight,e.min,e.max):null}switchPropertyType(t,e,n){if(!this.profile)return!1;const o=this.correctPropertyType(this.profile.properties[t],n);return!!o&&(this.profile.properties[t]=o,this.rebuildRow(t,e),!0)}rebuildRow(t,e){const n=this.rows[e],o=this.buildRow(t,e,this.profile.properties[t]);this.rows[e]=o,(null==n?void 0:n.parentNode)&&n.replaceWith(o),this.emitChange()}buildModeGear(t,e,n){const o=ot.icons.settings(()=>{var o,r;const i=this.getPropertyNameByRowId(t);if(!i)return;const s=this.columnMapping[i],a=s&&null!==(r=null===(o=this.dataFrame)||void 0===o?void 0:o.col(s))&&void 0!==r?r:null;this.openModeDialog(i,t,e,n,a)});return o.classList.add("statistics-mpo-gear"),o}buildRowControls(t){const e=ot.icons.add(()=>this.insertRowAfterRow(t)),n=ot.icons.delete(()=>this.deleteRow(t));return ot.divH([e,n],"statistics-mpo-control-buttons")}openModeDialog(t,e,n,o,r=null){new Pn(t,n,e=>{var n;const r=null===(n=this.profile)||void 0===n?void 0:n.properties[t];r&&Object.assign(r,e),o.redrawAll()},n=>{this.profile&&(this.profile.properties[t]=n,this.rebuildRow(t,e))},r).show()}getPropertyNameByRowId(t){var e;return null===(e=Object.entries(this.rowIds).find(([,e])=>e===t))||void 0===e?void 0:e[0]}renameProperty(t,e){var n;if(!this.profile||this.profile.properties[e])return;const o=this.rowIds[t];this.profile.properties[e]=this.profile.properties[t],delete this.profile.properties[t],this.columnMapping[e]=null!==(n=this.columnMapping[t])&&void 0!==n?n:null,delete this.columnMapping[t];const r=this.propertyOrder.indexOf(t);r>=0&&(this.propertyOrder[r]=e),delete this.rowIds[t],this.rowIds[e]=o,this.emitChange()}deleteRow(t){var e;const n=this.getPropertyNameByRowId(t);if(!n||!this.profile)return;delete this.profile.properties[n],delete this.columnMapping[n],delete this.rowIds[n],null===(e=this.rowSubs.get(t))||void 0===e||e.unsubscribe(),this.rowSubs.delete(t);const o=this.propertyOrder.indexOf(n);o>=0&&this.propertyOrder.splice(o,1);const r=this.rows[t];delete this.rows[t],0===this.propertyOrder.length?this.render():null==r||r.remove(),this.emitChange()}insertRowAfterRow(t){var e;if(!this.profile)return;const n=this.getPropertyNameByRowId(t);if(!n)return;const o=`NewProperty${Object.keys(this.profile.properties).length+1}`,r=this.newRowId();this.profile.properties[o]=pn(),this.rowIds[o]=r;const i=this.propertyOrder.indexOf(n);this.propertyOrder.splice(i+1,0,o);const s=this.buildRow(o,r,this.profile.properties[o]);this.rows[r]=s,null===(e=this.rows[t])||void 0===e||e.after(s),this.emitChange()}mutateProperty(t,e){var n;const o=null===(n=this.profile)||void 0===n?void 0:n.properties[t];o&&(e(o),this.emitChange())}emitChange(){this.onChanged.next(),I.events.fireCustomEvent("grok-mpo-score-changed",{})}}var Kn=s(4884),zn={};zn.styleTagTransform=Yn(),zn.setAttributes=Gn(),zn.insert=Un().bind(null,"head"),zn.domAPI=Bn(),zn.insertStyleElement=Hn(),Fn()(Kn.A,zn),Kn.A&&Kn.A.locals&&Kn.A.locals;const Qn="pMPO is not applicable",Zn="Failed to compute pMPO parameters",Jn="desired",to="non-desired",eo="Mean",no="p-value",oo=new Map([["desAvg",`${eo}(${Jn})`],["desStd",`Std(${Jn})`],["nonDesAvg",`${eo}(${to})`],["nonDesStd",`Std(${to})`],["tstat","t-statistics"],["pValue",no]]),ro="Descriptor",io=ro+" Statistics",so="Selected",ao="Weight",lo="pMPO score",uo="Desirability Curve",co=.001,fo=.001,ho=.53,mo=.01,po=.05,go=.01,vo="0.000";var yo;!function(t){t.SELECTED="rgb(26, 146, 26)",t.SKIPPED="rgb(208, 57, 67)"}(yo||(yo={}));const Ao="System:AppData/Chem/mpo",wo=[0,.25,.5,1,1.5,2,2.5,3,4,5],Co=wo.slice(1).map(t=>-t).reverse().concat(wo),Eo=wo.concat([.12,.37,.63,.75,.88,1.25,1.75,2.25,2.75]).sort(),bo=Eo.slice(1).map(t=>-t).reverse().concat(Eo),xo="TPR (Sensitivity)",_o="FPR (1 - Specificity)",No=101,Mo=new Float32Array(Array.from({length:No},(t,e)=>e/100)),To="System:AppData/Eda/drugs-props-train.csv",So="System:AppData/Eda/drugs-props-train-scores.csv",Oo=new Map([["tolerance",.001],["maxIter",25],["nonZeroParam",1e-4],["initialScale",.02],["scaleReflaction",1],["scaleExpansion",2],["scaleContraction",-.5]]),Io=new Float32Array([.5,go]),Lo=new Float32Array([1,1]);var Po;!function(t){t.GREATER=">",t.LESS="<",t.GREATER_OR_EQUAL="≥",t.LESS_OR_EQUAL="≤",t.DEFAULT="≤"}(Po||(Po={}));const Ro=[Po.GREATER,Po.LESS,Po.GREATER_OR_EQUAL,Po.LESS_OR_EQUAL],Fo=["perfect","good","true","t","g","active","a","yes","y"];function Do(t,e){const n=t.groupBy([e.name]).getGroups();let o,r;for(const t in n)t.toLowerCase().includes("true")?o=n[t]:r=n[t];return{desired:o,nonDesired:r}}function Bo(t,e){const n=t.length,o=e.length;if(n<2||o<2)throw new Error(`Failed to compute the "${t.name}" descriptor statistics: \n      both samples must have at least two observations.`);const r=t.stats.avg,i=e.stats.avg,s=t.stats.variance,a=e.stats.variance,l=t.stats.stdev,u=e.stats.stdev,c=Math.sqrt(s/n+a/o);if(0===c)throw new Error(`Failed to compute the "${t.name}" descriptor statistics: \n      zero variance.`);const f=(r-i)/c,d=Math.pow(s/n+a/o,2)/(s*s/(n*n*(n-1))+a*a/(o*o*(o-1))),h=2*(1-tn.studentt.cdf(Math.abs(f),d));return{desAvg:r,desStd:l,desLen:n,nonDesAvg:i,nonDesStd:u,nonSesLen:o,min:Math.min(t.stats.min,e.stats.min),max:Math.max(t.stats.max,e.stats.max),tstat:f,pValue:h}}function ko(e,n,o){if(e.length!==n.length)throw new Error("Failed to compute confusion matrix: columns have different lengths.");if(e.type!==t.COLUMN_TYPE.BOOL)throw new Error("Failed to compute confusion matrix: desirability column must be boolean.");if(!n.isNumerical)throw new Error("Failed to compute confusion matrix: prediction column must be numerical.");let r=0,i=0,s=0,a=0;const l=e.getRawData(),u=n.getRawData();let c=0,f=0,d=l[0];for(let t=0;t<n.length;++t)1==(d>>>f&1)?u[t]>=o?++r:++a:u[t]>=o?++s:++i,++f,f>=32&&(f=0,++c,d=l[c]);return{TP:r,TN:i,FP:s,FN:a}}function Uo(t,e){if(t.length!==e.length)throw new Error("Failed to compute AUC: TPR and FPR arrays have different lengths.");let n=0;for(let o=1;o<t.length;++o)n+=Math.abs(e[o]-e[o-1])*((t[o]+t[o-1])/2);return n}function Vo(t,e){const n=new Float32Array(No),o=new Float32Array(No);let r=-1,i=-1,s=Mo[0];for(let a=0;a<No;++a){const l=ko(t,e,Mo[a]);n[a]=l.TP+l.FN>0?l.TP/(l.TP+l.FN):0,o[a]=l.FP+l.TN>0?l.FP/(l.FP+l.TN):0,i=n[a]-o[a],i>r&&(r=i,s=Mo[a])}return{auc:Uo(n,o),threshold:s,tpr:n,fpr:o}}var Go,$o,Ho,qo,Yo;!function(t){t.MIN="minimize",t.MAX="maximize"}(Go||(Go={})),function(t){t.OPTIMAL="optimal",t.NON_OPT="non-optimal"}($o||($o={})),function(t){t[t.FORM=.15]="FORM",t[t.VIEWER=.5]="VIEWER"}(Ho||(Ho={})),function(t){t.OPT="Pareto optimality",t.SIZE="Pareto size"}(qo||(qo={})),function(t){t[t.OPTIMAL=8]="OPTIMAL",t[t.NON_OPT=4]="NON_OPT"}(Yo||(Yo={}));const Wo=[t.Color.darkGreen,t.Color.yellow,t.Color.darkRed];function jo(t){return t===Go.MIN?[...Wo]:[...Wo].reverse()}function Xo(e,n=!0){const o=ot.label("Color scale:");o.style.paddingRight="7px";const r=[o],i=ot.label(n?"min":"worst"),s=ot.label(". . ."),a=ot.label(n?"max":"best"),l=jo(e),u=[i,s,a].map((e,n)=>(1!==n&&(e.style.fontWeight="bold",e.style.color=t.Color.toRgb(l[n])),e.style.marginRight="5px",e));return r.push(...u),ot.divH(r)}var 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descriptors.`,i,s):ot.tooltip.show(`No weight: <b>${o}</b> is excluded due to a high p-value.`,i,s),!0);if(e.includes(l)&&!n.includes(o))return ot.tooltip.show(`<b>${o}</b> is excluded due to a high p-value; so correlation with <b>${l}</b> is not needed.`,i,s),!0}return!1}});const i=r.col(uo);r.setOptions({rowHeight:75}),i.width=305,i.cellType="html",r.onCellPrepare(t=>{if(null==t.tableColumn)return;if(null==t.tableColumn)return;if(!t.isTableCell)return;if(t.tableColumn.name!==uo)return;const e=r.cell(ro,t.gridRow).value,o=this.desirabilityProfileRoots.get(e);if(null!=o)t.element=o;else{const o=n.includes(e),r=o?"highly correlated with other descriptors":"statistically insignificant",i=o?`No chart shown: <b>${e}</b> is excluded due to a high correlation with other descriptors.`:`No chart shown: <b>${e}</b> is excluded due to a high p-value.`,s=ot.divText(r);s.style.color=yo.SKIPPED,s.classList.add("eda-pmpo-centered-text"),ot.tooltip.bind(s,i),t.element=s}})}updateGrid(){const t=this.view.grid,e=this.predictionName;t.sort([this.predictionName],[!1]);const n=t.col(e);n.format="0.0000",n.isTextColorCoded=!0,t.onCellTooltip((t,n,o)=>{var r;if(t.isColHeader&&t.tableColumn)return t.tableColumn.name===e?(ot.tooltip.show(ot.divV([ot.h2(lo),ot.divText("Scores computed using the trained probabilistic multi-parameter optimization (pMPO) model."),Xo(Go.MAX,!1)]),n,o),!0):null!=this.tresholdedColumn&&t.tableColumn.name===this.tresholdedColumn.name&&(ot.tooltip.show(ot.markdown(null!==(r=this.threshColTooltip)&&void 0!==r?r:""),n,o),!0)})}updateDesirabilityProfileData(t,e){if(null==this.params)return;this.desirabilityProfileRoots.forEach(t=>t.remove()),this.desirabilityProfileRoots.clear();const n=nr(this.params,e,"","",!0);this.desirabilityProfile=nr(this.params,e,"","",!1);const o=t.col(ro).toList(),r=t.col(ao).getRawData(),i=n.properties,s=Object.keys(i);for(const t of s)r[o.indexOf(t)]=i[t].weight;const a=new Xn;a.setProfile(n);const l=a.root.querySelector("div.d4-flex-col.ui-div");null!=l&&l.querySelectorAll("div.d4-flex-row.ui-div.statistics-mpo-row").forEach((t,e)=>{const n=t.children;if(n.length<2)return;const o=n[2];o.style.width="100%",this.desirabilityProfileRoots.set(s[e],o)})}updateRocCurve(e,n){const o=Vo(e,n),r=t.DataFrame.fromColumns([t.Column.fromFloat32Array("Threshold",Mo),t.Column.fromFloat32Array(_o,o.fpr),t.Column.fromFloat32Array(xo,o.tpr)]);return r.meta.formulaLines.addLine({title:"Non-informative baseline",formula:`\${${xo}} = \${${_o}}`,width:1,style:"dashed",min:0,max:1}),this.rocCurve.dataFrame=r,this.rocCurve.setOptions({xColumnName:_o,yColumnName:xo,linesOrderColumnName:_o,linesWidth:5,markerType:"dot",title:`ROC Curve (AUC = ${o.auc.toFixed(3)})`}),o.threshold}updateConfusionMatrix(t,e,n){this.confusionMatrix.dataFrame=t,this.confusionMatrix.setOptions({xColumnName:e,yColumnName:this.boolPredictionName,description:`Threshold: ${n.toFixed(3)} (optimized via Youden's J)`,title:e+" Confusion Matrix"})}getIndecesOfMissingValues(t){const e=[];return t.forEach(t=>{const n=this.missingValsIndeces.get(t);null!=n&&e.push(...n)}),e}setNulls(e,n){const o=e.getRawData();n.forEach(e=>o[e]=t.FLOAT_NULL)}fitAndUpdateViewers(e,n,o,r,i,s,a){const l=mr.fit(e,n,o,r,i,s);this.params=l.params;const u=l.descrStatsTable,c=l.selectedByPvalue,f=l.selectedByCorr,d=n.names(),h=mr.predict(e,this.params,a,this.predictionName),m=this.getIndecesOfMissingValues(f);this.setNulls(h,m),h.colors.setLinear(jo(Go.MAX),{min:h.stats.min,max:h.stats.max}),e.columns.remove(this.predictionName),e.columns.add(h),this.updateGrid(),this.updateDesirabilityProfileData(u,a),this.updateStatisticsGrid(u,d,c,f);const p=this.updateRocCurve(o,h),g=o.name;e.columns.remove(this.boolPredictionName),this.boolPredictionName=e.columns.getUnusedName(g+"(predicted)");const v=function(e,n,o){if(!e.isNumerical)throw new Error("Failed to compute confusion matrix: prediction column must be numerical.");const r=e.length,i=new Array(r),s=e.getRawData();for(let t=0;t<r;++t)i[t]=s[t]>=n;return t.Column.fromList(t.COLUMN_TYPE.BOOL,o,i)}(h,p,this.boolPredictionName);e.columns.add(v),this.updateConfusionMatrix(e,g,p),this.view.dataFrame.selection.setAll(!1,!0)}runTrainingApp(){const e=this.view.dockManager;e.dock(this.getInputForm(!0).form,t.DOCK_TYPE.LEFT,null,void 0,.1);const n=e.findNode(this.view.grid.root);if(null==n)throw new Error("Failed to train pMPO: missing a grid in the table view.");const o=e.dock(this.statGrid,t.DOCK_TYPE.DOWN,n,void 0,.5),r=e.dock(this.rocCurve,t.DOCK_TYPE.RIGHT,o,void 0,.3);e.dock(this.confusionMatrix,t.DOCK_TYPE.RIGHT,r,void 0,.2),this.setRibbons()}getPmpoAppItems(){return{statsGrid:this.statGrid,rocCurve:this.rocCurve,confusionMatrix:this.confusionMatrix,controls:this.getInputForm(!1),profile:this.desirabilityProfile}}getInputForm(e){const n=ot.form([]);n.append(ot.h2("Training data"));const o=function(e){for(const n of e)if(n.type===t.COLUMN_TYPE.BOOL&&n.stats.stdev>0)return n;for(const t of e)if(t.isNumerical&&t.stats.stdev>0)return t;return e[0]}(this.desirabilityColumns),r=()=>{if(null!=this.tresholdedColumn&&(this.table.columns.remove(this.tresholdedColumn.name),this.tresholdedColumn=null),l.value.type===t.COLUMN_TYPE.BOOL)return l.value;const e=l.value.type===t.COLUMN_TYPE.STRING?function(e,n){const o=new Array(e.length),r=e.getRawData(),i=e.categories;for(let t=0;t<e.length;++t)o[t]=n.includes(i[r[t]]);const s=i.filter(t=>!n.includes(t)),a=`✅ ${n.join(", ")}`,l=`❌ ${s.join(", ")}`;return{column:t.Column.fromList(t.COLUMN_TYPE.BOOL,"",o),tooltip:`Desirability based on the selected categories:\n\n **${a}**\n\n **${l}**`}}(l.value,h.value):function(e,n,o){const r=new Array(e.length),i=e.getRawData(),s=function(t){switch(t){case Po.LESS:return(t,e)=>t<e;case Po.LESS_OR_EQUAL:return(t,e)=>t<=e;case Po.GREATER:return(t,e)=>t>e;case Po.GREATER_OR_EQUAL:return(t,e)=>t>=e;default:throw new Error(`Unsupported sign: ${t}`)}}(o);for(let t=0;t<e.length;++t)r[t]=s(i[t],n);return{column:t.Column.fromList(t.COLUMN_TYPE.BOOL,"",r),tooltip:`Desirability based on the condition:\n\n **${e.name} ${o} ${n}**`}}(l.value,f.value,c.value);return this.tresholdedColumn=e.column,this.threshColTooltip=e.tooltip,this.tresholdedColumn.name=this.table.columns.getUnusedName("Desirability"),this.table.columns.add(this.tresholdedColumn),this.tresholdedColumn},i=()=>{if(w())try{this.fitAndUpdateViewers(this.table,t.DataFrame.fromColumns(s.value).columns,r(),b.value,x.value,_.value,g.value)}catch(t){if(t instanceof ar)I.shell.warning(t.message),ot.tooltip.bind(l.input,t.message),ot.tooltip.bind(s.input,t.message);else{const e=t instanceof Error?t.message:Zn+": the platform issue.";I.shell.error(e),ot.tooltip.bind(l.input,e),ot.tooltip.bind(s.input,e)}l.input.classList.add("d4-invalid"),s.input.classList.add("d4-invalid")}},s=ot.input.columns("Descriptors",{table:this.table,nullable:!1,available:this.numericCols.map(t=>t.name),checked:this.numericCols.filter(t=>t.name!==o.name&&t.stats.stdev>0&&t.stats.missingValueCount<t.length).map(t=>t.name),tooltipText:"Descriptor columns used for model construction.",onValueChanged:t=>{null!=t&&(y=!1,C())}});n.append(s.root),s.addValidator(()=>{if(null==s.value||s.value.length<1)return"Select at least one descriptor column.";if(null!=l.value&&s.value.includes(l.value))return"Desirability column cannot be used as a descriptor.";const t=s.value.filter(t=>0===t.stats.stdev).map(t=>t.name);if(t.length>0)return`Descriptor columns with zero variance: ${t.join(", ")}`;const e=s.value.filter(t=>t.stats.missingValueCount===t.length).map(t=>t.name);return e.length>0?`Descriptor columns with only missing values: ${e.join(", ")}`:null});const a=e=>{if(e.type===t.COLUMN_TYPE.BOOL)d.hidden=!0;else{d.hidden=!1;const n=e.type===t.COLUMN_TYPE.STRING;f.root.hidden=n,c.root.hidden=n}},l=ot.input.column("Desirability",{nullable:!1,value:o,table:this.table,filter:t=>this.desirabilityColumns.includes(t),tooltipText:"Desirability column.",onValueChanged:t=>{null!=t&&(m(),a(t),u=!0,f.value=Math.round(100*t.stats.avg)/100,u=!1,y=!1,C())}});n.append(l.root),l.addValidator(()=>{if(null==l.value)return"Select a desirability column.";if(null!=s.value&&s.value.includes(l.value))return"Desirability column cannot be used as a descriptor.";if(l.value.type===t.COLUMN_TYPE.BOOL){if(0===l.value.stats.stdev)return"All desirability values are the same - scoring is not feasible."}else if(l.value.type===t.COLUMN_TYPE.STRING){if(l.value.categories.length<2)return"String desirability column must have at least 2 categories."}else{if(0===l.value.stats.stdev)return l.value.stats.missingValueCount<l.value.length?"All desirability values are the same - scoring is not feasible.":"Empty column cannot be used as desirability column.";if(null==f.value)return"Specify non-null desirability threshold.";if(!lr(l.value,f.value,c.value))return`All compounds are either desired or non-desired for ${l.value.name} ${c.value} ${f.value}. Adjust the threshold or condition.`}return null});let u=!1;const c=ot.input.choice("Condition",{value:Po.DEFAULT,items:Ro,nullable:!1,tooltipText:"How to compare numeric Desirability column values against the threshold.",onValueChanged:t=>{y=!1,C()}}),f=ot.input.float("Threshold",{value:Math.round(100*o.stats.avg)/100,nullable:!1,tooltipText:"Boundary value that separates desired from non-desired compounds.",format:"0.00",onValueChanged:t=>{if(null!=t){if(u)return;y=!1,C()}}});f.addValidator(()=>null==l.value||l.value.type===t.COLUMN_TYPE.BOOL||l.value.type===t.COLUMN_TYPE.STRING?null:null==f.value?"Specify non-null desirability threshold.":lr(l.value,f.value,c.value)?null:"Adjust the threshold to get both desired and non-desired groups.");const d=ot.divV([c.root,f.root]);n.append(d);let h=null;const m=()=>{var e;null!=h&&(h.root.remove(),h=null),(null===(e=l.value)||void 0===e?void 0:e.type)===t.COLUMN_TYPE.STRING&&(h=ot.input.multiChoice("Preferred",{value:ur(l.value.categories),items:l.value.categories,nullable:!1,tooltipText:"Select which categories should be treated as desirable.",onValueChanged:t=>{if(null!=t){if(u)return;y=!1,C()}}}),h.addValidator(()=>null==h.value||0===h.value.length?"Select at least one preferable category.":null!=l.value&&h.value.length===l.value.categories.length?"At least one category must be non-preferable.":null),d.append(h.root))};a(l.value);const p=ot.h2("Settings");n.append(p),ot.tooltip.bind(p,"Settings of the pMPO model.");const g=ot.input.bool("σ correction",{value:!0,tooltipText:"Use the sigmoidal correction to the weighted Gaussian scores.",onValueChanged:t=>{y=!1,C()}});n.append(g.root);const v=this.table.rowCount<=1e4;let y=!1;const A=()=>hr(this,void 0,void 0,function*(){if(yield new Promise(t=>setTimeout(t,50)),w())if(y)i();else{const e=yield this.getOptimalSettings(t.DataFrame.fromColumns(s.value).columns,r(),g.value);"success"===e.state?(b.value=Math.max(e.pValTresh,fo),x.value=Math.max(e.r2Tresh,mo),_.value=Math.max(e.qCutoff,go),y=!0,i()):I.shell.warning(e.msg)}}),w=()=>{const t=[s.validate(),l.validate(),f.validate(),b.validate(),x.validate(),_.validate()];return null!=h&&t.push(h.validate()),t.every(t=>t)},C=()=>{E.value?A():i()},E=ot.input.bool("Auto-tuning",{value:!1,tooltipText:"Automatically select optimal p-value, R², and q-cutoff by maximizing AUC.",onValueChanged:t=>hr(this,void 0,void 0,function*(){N(!t),y||(t?yield A():i())})});n.append(E.root);const b=ot.input.float("p-value",{nullable:!1,min:fo,max:1,step:.001,value:co,format:vo,tooltipText:"P-value threshold. Descriptors with p-values above this threshold are excluded.",onValueChanged:t=>{E.value||(y=!1,null!=t&&t>=fo&&t<=1&&i())}});n.append(b.root),b.addValidator(()=>null==b.value?"P-value is required.":b.value<fo||b.value>1?"P-value must be between 0.001 and 1.":null);const x=ot.input.float("R²",{format:vo,nullable:!1,min:mo,value:ho,max:1,step:.01,tooltipText:"Squared correlation threshold. Descriptors with squared correlation above this threshold are considered highly correlated. Among them, the descriptor with the lower p-value is retained.",onValueChanged:t=>{E.value||(y=!1,null!=t&&t>=mo&&t<=1&&i())}});n.append(x.root),x.addValidator(()=>null==x.value?"R² is required.":x.value<mo||x.value>1?"R² must be between 0.01 and 1.":null);const _=ot.input.float("q-cutoff",{format:vo,nullable:!1,min:go,value:po,max:1,step:.01,tooltipText:"Q-cutoff for the pMPO model computation.",onValueChanged:t=>{E.value||(y=!1,null!=t&&t>=go&&t<=1&&i())}});n.append(_.root),_.addValidator(()=>null==_.value?"Q-cutoff is required.":_.value<go||_.value>1?"Q-cutoff must be between 0.01 and 1.":null);const N=t=>{b.enabled=t,x.enabled=t,_.enabled=t};setTimeout(()=>{i(),v?E.value=!0:i()},10);const M=ot.button("Save",()=>hr(this,void 0,void 0,function*(){null!=this.params?function(t,e,n){Ko(this,void 0,void 0,function*(){const o=ot.input.string("Name",{value:e,nullable:!1}),r=ot.input.textArea("Description",{value:" ",nullable:!0}),i=ot.input.bool("Desirability Profile",{value:!0,tooltipText:"Save the model as an MPO Desirability Profile. If disabled, the model is saved in the pMPO format."}),s=ot.dialog({title:"Save model"}).add(o).add(r).add(i).addButton("Save",()=>Ko(this,void 0,void 0,function*(){try{const e=yield I.dapi.files.list(Ao),s=new Set(e.map(t=>t.name)),a=function(t,e){return function(t,e,n){const o=n(t);if(!e.has(o))return o;let r=2;for(;e.has(n(t,r));)r++;return n(t,r)}(t.trim().replace(/[\s/\\]+/g,"-").replace(/^-|-$/g,"")||"profile",e,(t,e)=>e?`${t}-${e}.json`:`${t}.json`)}(o.value,s),l=`${Ao}/${a}`,u=JSON.stringify(i.value?nr(t,n,o.value,r.value,!1):{type:"Probabilistic MPO Model",name:o.value,description:r.value,properties:Object.fromEntries(t)},null,2);yield I.dapi.files.writeAsText(l,u),I.events.fireCustomEvent("chem-mpo-profile-changed",{}),I.shell.info(`Saved to ${l}`)}catch(t){I.shell.error(`Failed to save: ${t instanceof Error?t.message:"the platform issue"}.`)}s.close()})).show();s.getButton("Save").disabled=!o.validate(),o.onInput.subscribe(()=>s.getButton("Save").disabled=!o.validate())})}(this.params,this.table.name,g.value):I.shell.warning("Failed to save pMPO model: null parameters.")}),"Save model as platform file.");e&&n.append(M);const T=ot.div([n]);return T.classList.add("eda-pmpo-input-form"),{form:T,saveBtn:M}}static validateInputs(e){var n;const o=new Map,{descriptors:r,desirability:i,threshold:s,sign:a,desirableCategories:l,pValue:u,r2:c,qCutoff:f}=e;if(null==u||null==c||null==f)return{valid:!1,errors:o};if(u<=0||u>1||c<0||c>1||f<=0||f>1)return{valid:!1,errors:o};if(null==r||null==i)return{valid:!1,errors:o};if(r.length<1)return o.set("descriptors","Select at least one descriptor column."),{valid:!1,errors:o};if(r.includes(i)){const t="Desirability column cannot be used as a descriptor.";return o.set("descriptors",t),o.set("desirability",t),{valid:!1,errors:o}}const d=r.filter(t=>0===t.stats.stdev).map(t=>t.name);d.length>0&&o.set("descriptors",()=>ot.markdown(`Descriptor columns with zero variance cannot be used: **${d.join(", ")}**`));const h=r.filter(t=>t.stats.missingValueCount===t.length).map(t=>t.name);if(h.length>0&&o.set("descriptors",()=>ot.markdown(`Descriptor columns with only missing values cannot be used: **${h.join(", ")}**`)),i.type===t.COLUMN_TYPE.BOOL)0===i.stats.stdev&&o.set("desirability","All desirability values are the same - scoring is not feasible.");else if(i.type===t.COLUMN_TYPE.STRING){const t=i.categories.length,e=null!==(n=null==l?void 0:l.length)&&void 0!==n?n:0;t<2?o.set("desirability","String desirability column must have at least 2 categories."):0===e?o.set("desirability","Select at least one preferable category."):e===t&&o.set("desirability","At least one category must be non-preferable.")}else 0===i.stats.stdev?o.set("desirability",i.stats.missingValueCount<i.length?"All desirability values are the same - scoring is not feasible.":"Empty column cannot be used as desirability column."):null==s?o.set("desirability","Specify non-null desirability threshold."):lr(i,s,a)||(o.set("desirability",()=>ot.markdown(`All compounds are either desired or non-desired for\n          <div align="center">\n          **${i.name} ${a} ${s}.**\n          </div>\n          Adjust the threshold or condition to get both groups.`)),o.set("threshold","Adjust the threshold to get both desired and non-desired groups."));return{valid:!o.size,errors:o}}getDesirabilityColumns(){const e=[];for(const n of this.table.columns)(n.type===t.COLUMN_TYPE.BOOL||n.isNumerical||n.type===t.COLUMN_TYPE.STRING)&&e.push(n);return e}getValidNumericCols(){const t=[];for(const e of this.table.columns)e.isNumerical&&t.push(e);return t}getOptimalSettings(e,n,o){return hr(this,void 0,void 0,function*(){const r=t.TaskBarProgressIndicator.create("Optimizing... ",{cancelable:!0});try{const t=e.names(),{desired:i,nonDesired:s}=Do(this.table,n),a=new Map;t.forEach(t=>{a.set(t,Bo(i.col(t),s.col(t)))});const l=Qo(zo(a),co);if(l.length<1)return r.close(),{pValTresh:0,r2Tresh:0,qCutoff:0,state:"failed",msg:"No descriptors passed the p-value threshold filter."};const u=Jo(e,l),c=t=>{const e=tr(0,l,a,t[0],u),r=er(i,s,e,t[1]),c=mr.predict(this.table,r,o,this.predictionName);return 1-Vo(n,c).auc},f=yield dr(r,c,new Float32Array([ho,po]),Oo,Io,Lo),d=!r.canceled;return r.close(),d?{pValTresh:co,r2Tresh:f.optimalPoint[0],qCutoff:f.optimalPoint[1],state:"success",msg:"Optimization completed successfully."}:{pValTresh:0,r2Tresh:0,qCutoff:0,state:"canceled",msg:"Auto-tuning was canceled by the user."}}catch(t){return r.close(),{pValTresh:0,r2Tresh:0,qCutoff:0,state:"failed",msg:t instanceof Error?t.message:"Optimization failed due to an unexpected error."}}})}}function pr(e){return n=this,o=arguments,i=function*(e,n=!0){const o=yield I.dapi.files.readCsv(To),r=new gr(o,"Drug","CNS","Smiles").getGenerated(e);if(!n){r.columns.add(t.Column.fromList(t.COLUMN_TYPE.BOOL,"Const bool",new Array(e).fill(!0))),r.columns.add(t.Column.fromInt32Array("Const int",new Int32Array(e).fill(1)));const n=r.columns.toList().find(t=>t.isNumerical);if(n){const e=n.clone();e.name=`${n.name} (missing)`;for(let n=0;n<Math.min(5,e.length);++n)e.set(n,t.FLOAT_NULL);r.columns.add(e)}r.columns.add(t.Column.fromFloat32Array("Nulls",new Float32Array(e).fill(t.FLOAT_NULL)));const o=function(e,n){const o=e.toList(),r=new Array(n),i=new Array(n);for(let t=0;t<n;++t)r[t]=o[t]?"active":"non-active",i[t]=o[t]?Math.random()<.5?"perfect":"good":Math.random()<.5?"bad":"worst";return[t.Column.fromList(t.COLUMN_TYPE.STRING,"CNS (strings)",r),t.Column.fromList(t.COLUMN_TYPE.STRING,"CNS (4 categories)",i),t.Column.fromList(t.COLUMN_TYPE.STRING,"Single category",new Array(n).fill("Unknown"))]}(r.col("CNS"),e);for(const t of o)r.columns.add(t)}return r},new((r=void 0)||(r=Promise))(function(t,e){function s(t){try{l(i.next(t))}catch(t){e(t)}}function a(t){try{l(i.throw(t))}catch(t){e(t)}}function l(e){var n;e.done?t(e.value):(n=e.value,n instanceof r?n:new r(function(t){t(n)})).then(s,a)}l((i=i.apply(n,o||[])).next())});var n,o,r,i}class gr{constructor(t,e,n,o){this.sourceDf=t,this.drugName=e,this.desirabilityColName=n,this.smilesColName=o;const r=t.columns.toList().filter(t=>t.isNumerical).map(t=>t.name),{desired:i,nonDesired:s}=Do(t,t.col(n));this.descriptorStats=new Map,r.forEach(t=>{this.descriptorStats.set(t,Bo(i.col(t),s.col(t)))}),this.desiredProbability=i.rowCount/t.rowCount}getGenerated(e){if(e<=1)throw new Error("Failed to generate pMPO data: sample count must be greater than 1.");let n;if(e<=this.sourceDf.rowCount){const o=t.BitSet.create(this.sourceDf.rowCount);for(let t=0;t<e;++t)o.set(t,!0);n=this.sourceDf.clone(o)}else n=this.getClonedSourceDfWithFloatNumericCols().append(this.getSyntheticTable(e-this.sourceDf.rowCount));for(const e of n.columns)if(e.type===t.COLUMN_TYPE.BOOL&&0===e.stats.stdev){let t=e.get(0);e.set(0,!t),t=e.get(1),e.set(1,!t)}return n}getSyntheticTable(e){const n=new Array(e);for(let t=0;t<e;++t)n[t]=Math.random()<this.desiredProbability;const o=[this.getDrugColumn(e),this.getSmilesColumn(e),t.Column.fromList(t.COLUMN_TYPE.BOOL,this.desirabilityColName,n)];return this.descriptorStats.forEach((r,i)=>{const s=new Float32Array(e);for(let t=0;t<e;++t)n[t]?s[t]=tn.normal.sample(r.desAvg,r.desStd):s[t]=tn.normal.sample(r.nonDesAvg,r.nonDesStd);o.push(t.Column.fromFloat32Array(i,s))}),t.DataFrame.fromColumns(o)}getDrugColumn(e){return t.Column.fromList(t.COLUMN_TYPE.STRING,this.drugName,Array.from({length:e},(t,e)=>`Synthetic drug ${e+1}`))}getSmilesColumn(e){return t.Column.fromList(t.COLUMN_TYPE.STRING,this.smilesColName,Array.from({length:e},()=>"C"))}getClonedSourceDfWithFloatNumericCols(){const e=[];this.sourceDf.columns.toList().forEach(n=>{n.isNumerical?e.push(n.clone().convertTo(t.COLUMN_TYPE.FLOAT)):e.push(n.clone())});const n=t.DataFrame.fromColumns(e);return n.name=this.sourceDf.name,n}}var vr=function(t,e,n,o){return new(n||(n=Promise))(function(r,i){function s(t){try{l(o.next(t))}catch(t){i(t)}}function a(t){try{l(o.throw(t))}catch(t){i(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n(function(t){t(e)})).then(s,a)}l((o=o.apply(t,e||[])).next())})};const yr="CNS",Ar=["TPSA","TPSA_S","HBA","HBD","MW","nAtoms","cLogD_ACD_v15","mapKa","cLogP_Biobyte","mbpKa","cLogP_ACD_v15","ALogP98"],wr="Score",Cr="Drug",Er="Sigmoidal",br=[Er,"Gaussian"];function xr(e=20){const n=Math.floor(e/2),o=[],r=new Float64Array(e),i=new Float64Array(e),s=new Float64Array(e);for(let t=0;t<e;t++){o.push(t<n);const e=t<n?t:t-n,a=e/Math.max(n-1,1);r[t]=t<n?9+2*a:1+2*a,i[t]=t<n?18+4*a:3+4*a,s[t]=5+.1*e}return t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",o),t.Column.fromFloat64Array("d1",r),t.Column.fromFloat64Array("d2",i),t.Column.fromFloat64Array("d3",s)])}function _r(e,n){return t.DataFrame.fromColumns(e.columns.byNames(n)).columns}function Nr(){const t=xr();return{descriptors:t.columns.byNames(["d1","d2"]),desirability:t.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po}}function Mr(t,e,n,o){if(0===n)return[];const r=t.length;if(e.length!==r)throw new Error("Sense array length must match number of dimensions");const i=new Uint32Array(n);for(let t=0;t<n;t++)i[t]=t;i.sort((n,o)=>e[0]===Go.MIN?t[0][n]-t[0][o]:t[0][o]-t[0][n]);const s=Array(n).fill(!0),a=[];null==o||o.forEach(t=>s[t]=!1);for(const n of i){if(!s[n])continue;let o=!1;for(const i of a){let s=!0,a=!1;for(let o=0;o<r;o++){const r=t[o][i],l=t[o][n];e[o]===Go.MIN?(r>l&&(s=!1),r<l&&(a=!0)):(r<l&&(s=!1),r>l&&(a=!0))}if(s&&a){o=!0;break}}o?s[n]=!1:a.push(n)}return s}b("Probabilistic MPO: Computation",()=>{br.forEach(e=>{const n=e==Er;C("Correctness: "+e,()=>vr(void 0,void 0,void 0,function*(){let o=null,r=null,i=null,s=[],a=null,l=null,u=null,c=null;try{if(o=yield I.dapi.files.readCsv(To),r=yield I.dapi.files.readCsv(So),i=o.col(yr),s=o.columns.byNames(Ar),null==i)throw new Error;const f=mr.fit(o,t.DataFrame.fromColumns(s).columns,i,co,ho,po),d=mr.predict(o,f.params,n,wr);a=o.col(Cr),l=r.col(Cr),u=r.col(e),c=function(t,e,n,o){let r=0;const i=t.toList(),s=n.toList(),a=e.getRawData(),l=o.getRawData();return i.forEach((t,e)=>{const n=s.indexOf(t);if(n<0)throw new Error(`Failed to compare pMPO scores: the "${t}" drug is missing in the reference data.`);r=Math.max(r,Math.abs(a[e]-l[n]))}),r}(a,d,l,u)}catch(t){I.shell.error(t.message)}E(null!==o,!0,"Failed to load the source data: "+To),E(null!==r,!0,"Failed to load the scores data: "+So),E(null!==i,!0,"Inconsistent source data: no column "+yr),E(s.length,Ar.length,"Inconsistent source data: no enough of columns"),E(null!==a,!0,"Inconsistent source data: no column "+Cr),E(null!==l,!0,"Inconsistent reference data: no column "+Cr),E(null!==u,!0,"Inconsistent reference data: no column "+wr),E(null!==c,!0,"Failed to compare pMPO scores with the reference data"),E(c<1e-6,!0,"Max absolute deviation of pMPO scores exceeds the threshold (0.000001)")}),{timeout:1e4})}),C("Performance: 100K drugs, "+Ar.length+" descriptors",()=>vr(void 0,void 0,void 0,function*(){let e=null,n=null,o=[];try{if(e=yield pr(1e5),n=e.col(yr),o=e.columns.byNames(Ar),null==n)throw new Error;const r=mr.fit(e,t.DataFrame.fromColumns(o).columns,n,co,ho,po);mr.predict(e,r.params,!0,wr)}catch(t){I.shell.error(t.message)}E(null!==e,!0,"Failed to load the source data: "+To),E(null!==n,!0,"Inconsistent source data: no column "+yr),E(o.length,Ar.length,"Inconsistent source data: no enough of columns")}),{timeout:1e4})}),b("Probabilistic MPO: API",()=>{C("isApplicable: rejects p-value below minimum",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=t.col("des"),n=_r(t,["d1","d2"]);E(mr.isApplicable(n,e,1e-4,ho,po),!1)})),C("isApplicable: rejects R² below minimum",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=t.col("des"),n=_r(t,["d1","d2"]);E(mr.isApplicable(n,e,co,.001,po),!1)})),C("isApplicable: rejects q-cutoff below minimum",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=t.col("des"),n=_r(t,["d1","d2"]);E(mr.isApplicable(n,e,co,ho,.001),!1)})),C("isApplicable: rejects too few samples",()=>vr(void 0,void 0,void 0,function*(){const t=xr(8),e=t.col("des"),n=_r(t,["d1","d2"]);E(mr.isApplicable(n,e,co,ho,po),!1)})),C("isApplicable: rejects single-category desirability",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",new Array(20).fill(!0)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=e.col("des"),o=_r(e,["d1","d2"]);E(mr.isApplicable(o,n,co,ho,po),!1)})),C("isApplicable: rejects non-numerical descriptor",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",Array.from({length:20},(t,e)=>e<10)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromStrings("strCol",Array.from({length:20},(t,e)=>"a"+e))]),n=e.col("des"),o=_r(e,["d1","strCol"]);E(mr.isApplicable(o,n,co,ho,po),!1)})),C("isApplicable: rejects all-constant descriptors",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",Array.from({length:20},(t,e)=>e<10)),t.Column.fromFloat64Array("c1",new Float64Array(20).fill(5)),t.Column.fromFloat64Array("c2",new Float64Array(20).fill(3))]),n=e.col("des"),o=_r(e,["c1","c2"]);E(mr.isApplicable(o,n,co,ho,po),!1)})),C("isApplicable: accepts valid data at minimum sample count",()=>vr(void 0,void 0,void 0,function*(){const t=xr(10),e=t.col("des"),n=_r(t,["d1","d2"]);E(mr.isApplicable(n,e,co,ho,po),!0)})),C("isTableValid: rejects table with 1 row",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("a",new Float64Array([1])),t.Column.fromFloat64Array("b",new Float64Array([2]))]);E(mr.isTableValid(e,!1),!1)})),C("isTableValid: rejects all-constant numeric columns",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("a",new Float64Array(10).fill(5)),t.Column.fromFloat64Array("b",new Float64Array(10).fill(3))]);E(mr.isTableValid(e,!1),!1)})),C("isTableValid: rejects single non-constant numeric column",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("a",Float64Array.from({length:10},(t,e)=>e)),t.Column.fromFloat64Array("b",new Float64Array(10).fill(3))]);E(mr.isTableValid(e,!1),!1)})),C("isTableValid: accepts two non-constant numeric columns",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("a",Float64Array.from({length:10},(t,e)=>e)),t.Column.fromFloat64Array("b",Float64Array.from({length:10},(t,e)=>2*e))]);E(mr.isTableValid(e,!1),!0)})),C("fit: returns non-empty params",()=>vr(void 0,void 0,void 0,function*(){const t=xr();E(mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po).params.size>0,!0,"Expected non-empty params")})),C("fit: weights sum to 1",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po);let n=0;e.params.forEach(t=>n+=t.weight),E(Math.abs(n-1)<1e-10,!0,`Weights sum ${n} should equal 1.0`)})),C("fit: selectedByCorr is subset of selectedByPvalue",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2","d3"]),t.col("des"),co,ho,po);E(e.selectedByCorr.every(t=>e.selectedByPvalue.includes(t)),!0,"selectedByCorr must be a subset of selectedByPvalue")})),C("fit: statistics table row count matches descriptor count",()=>vr(void 0,void 0,void 0,function*(){const t=["d1","d2","d3"],e=xr();E(mr.fit(e,_r(e,t),e.col("des"),co,ho,po).descrStatsTable.rowCount,t.length)})),C("fit: throws on non-applicable data",()=>vr(void 0,void 0,void 0,function*(){const t=xr(8);let e=!1;try{mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po)}catch(t){e=!0}E(e,!0,"Expected fit to throw on non-applicable data")})),C("fit: throws when no descriptors pass p-value filter",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",Array.from({length:20},(t,e)=>e<10)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e%10+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*(e%10+1)))]);let n=!1;try{mr.fit(e,_r(e,["d1","d2"]),e.col("des"),co,ho,po)}catch(t){n=!0}E(n,!0,"Expected fit to throw when no descriptors pass p-value filter")})),C("predict: returns column with correct length",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po);E(mr.predict(t,e.params,!0,wr).length,t.rowCount)})),C("predict: scores are non-negative",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po),n=mr.predict(t,e.params,!0,wr).getRawData();let o=!0;for(let t=0;t<n.length;t++)if(n[t]<0){o=!1;break}E(o,!0,"All scores should be non-negative")})),C("predict: scores do not exceed 1",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po),n=mr.predict(t,e.params,!0,wr).getRawData();let o=0;for(let t=0;t<n.length;t++)o=Math.max(o,n[t]);E(o<=1+1e-10,!0,`Max score ${o} should not exceed 1.0`)})),C("predict: sigmoid and Gaussian modes produce different scores",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=mr.fit(t,_r(t,["d1","d2"]),t.col("des"),co,ho,po),n=mr.predict(t,e.params,!0,"sig").getRawData(),o=mr.predict(t,e.params,!1,"gau").getRawData();let r=!1;for(let e=0;e<t.rowCount;e++)if(Math.abs(n[e]-o[e])>1e-12){r=!0;break}E(r,!0,"Sigmoid and Gaussian modes should produce different scores")})),C("predict: throws for missing column",()=>vr(void 0,void 0,void 0,function*(){const e=xr(),n=mr.fit(e,_r(e,["d1","d2"]),e.col("des"),co,ho,po),o=t.DataFrame.fromColumns([t.Column.fromFloat64Array("other",Float64Array.from({length:5},(t,e)=>e))]);let r=!1;try{mr.predict(o,n.params,!0,wr)}catch(t){r=!0}E(r,!0,"Expected predict to throw for missing column")})),C("validateInputs: rejects null p-value",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.pValue=null;const e=mr.validateInputs(t);E(e.valid,!1),E(e.errors.size,0,"No input-specific errors for null settings")})),C("validateInputs: rejects null R²",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.r2=null,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects null q-cutoff",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.qCutoff=null,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects p-value out of range",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.pValue=0,E(mr.validateInputs(t).valid,!1),t.pValue=1.5,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects R² out of range",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.r2=-.1,E(mr.validateInputs(t).valid,!1),t.r2=1.5,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects q-cutoff out of range",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.qCutoff=0,E(mr.validateInputs(t).valid,!1),t.qCutoff=1.5,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects null descriptors",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.descriptors=null,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects null desirability",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.desirability=null,E(mr.validateInputs(t).valid,!1)})),C("validateInputs: rejects empty descriptors",()=>vr(void 0,void 0,void 0,function*(){const t=Nr();t.descriptors=[];const e=mr.validateInputs(t);E(e.valid,!1),E(e.errors.has("descriptors"),!0)})),C("validateInputs: rejects desirability among descriptors",()=>vr(void 0,void 0,void 0,function*(){const t=xr(),e=t.col("des"),n=mr.validateInputs({descriptors:[t.col("d1"),e],desirability:e,threshold:null,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("descriptors"),!0),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects zero-variance descriptors",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",Array.from({length:20},(t,e)=>e<10)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("constCol",new Float64Array(20).fill(5))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("constCol")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("descriptors"),!0)})),C("validateInputs: accepts valid boolean desirability",()=>vr(void 0,void 0,void 0,function*(){const t=Nr(),e=mr.validateInputs(t);E(e.valid,!0),E(e.errors.size,0)})),C("validateInputs: rejects all-true boolean desirability",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromList(t.COLUMN_TYPE.BOOL,"des",new Array(20).fill(!0)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects string desirability with single category",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromStrings("des",new Array(20).fill("active")),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:["active"],pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects no selected categories",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromStrings("des",Array.from({length:20},(t,e)=>e<10?"active":"inactive")),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:[],pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects all categories selected",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromStrings("des",Array.from({length:20},(t,e)=>e<10?"active":"inactive")),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:["active","inactive"],pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: accepts valid string desirability",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromStrings("des",Array.from({length:20},(t,e)=>e<10?"active":"inactive")),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e<10?e+10:e)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>e<10?3*e:e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:["active"],pValue:co,r2:ho,qCutoff:po});E(n.valid,!0),E(n.errors.size,0)})),C("validateInputs: rejects constant numeric desirability",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("des",new Float64Array(20).fill(5)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:5,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects null threshold for numeric desirability",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("des",Float64Array.from({length:20},(t,e)=>e)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:null,sign:Po.DEFAULT,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0)})),C("validateInputs: rejects threshold producing single group",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("des",Float64Array.from({length:20},(t,e)=>e)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:100,sign:Po.LESS_OR_EQUAL,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!1),E(n.errors.has("desirability"),!0),E(n.errors.has("threshold"),!0)})),C("validateInputs: accepts valid numeric desirability with threshold",()=>vr(void 0,void 0,void 0,function*(){const e=t.DataFrame.fromColumns([t.Column.fromFloat64Array("des",Float64Array.from({length:20},(t,e)=>e)),t.Column.fromFloat64Array("d1",Float64Array.from({length:20},(t,e)=>e+1)),t.Column.fromFloat64Array("d2",Float64Array.from({length:20},(t,e)=>2*e))]),n=mr.validateInputs({descriptors:[e.col("d1"),e.col("d2")],desirability:e.col("des"),threshold:10,sign:Po.LESS_OR_EQUAL,desirableCategories:null,pValue:co,r2:ho,qCutoff:po});E(n.valid,!0),E(n.errors.size,0)}))});var Tr=function(t,e,n,o){return new(n||(n=Promise))(function(r,i){function s(t){try{l(o.next(t))}catch(t){i(t)}}function a(t){try{l(o.throw(t))}catch(t){i(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n(function(t){t(e)})).then(s,a)}l((o=o.apply(t,e||[])).next())})};const Sr=5e3,Or=1e6,Ir="1M points, 2D";function Lr(t,e,n=42){const o=[];let r=n;const i=()=>(r=(1664525*r+1013904223)%4294967296,r/4294967296);for(let n=0;n<e;n++){const e=new Float32Array(t);for(let 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e=null,n=null;try{const t=Lr(Or,2),n=Pr(2,"mixed"),o=Rr(Or,.25);e=Mr(t,n,Or,o),Fr(e,Or)}catch(t){n=t,I.shell.error(n.message)}E(null!==e,!0,"Failed to compute Pareto mask"),E(null===n,!0,null!==(t=null==n?void 0:n.message)&&void 0!==t?t:"")}),{timeout:Sr}),C("Edge case: Empty dataset",()=>Tr(void 0,void 0,void 0,function*(){var t;let e=null,n=null;try{e=Mr([new Float32Array(0),new Float32Array(0)],Pr(2,"mixed"),0)}catch(t){n=t,I.shell.error(n.message)}E(null!==e,!0,"Failed to compute Pareto mask"),E(e.length,0,"Empty dataset should return empty mask"),E(null===n,!0,null!==(t=null==n?void 0:n.message)&&void 0!==t?t:"")}),{timeout:Sr}),C("Edge case: Single point",()=>Tr(void 0,void 0,void 0,function*(){var t;let e=null,n=null;try{e=Mr([new Float32Array([1]),new Float32Array([2])],Pr(2,"mixed"),1)}catch(t){n=t,I.shell.error(n.message)}E(null!==e,!0,"Failed to compute Pareto mask"),E(e.length,1,"Single point dataset should return mask with one element"),E(e[0],!0,"Single point should be 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