@datagrok/bio 2.8.3 → 2.8.4

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Files changed (7) hide show
  1. package/CHANGELOG.md +4 -0
  2. package/dist/package-test.js +1 -1
  3. package/dist/package-test.js.map +1 -1
  4. package/dist/package.js +1 -1
  5. package/dist/package.js.map +1 -1
  6. package/package.json +4 -3
  7. package/src/viewers/web-logo-viewer.ts +35 -48
package/dist/package.js CHANGED
@@ -1,2 +1,2 @@
1
- var bio;(()=>{var t={6e3:(t,e,s)=>{"use strict";var i;s(4469),s(976),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(i||(i={}))},7997:(t,e,s)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function n(t){let e=0;for(let s=0;s<t.length;s++)e+=t[s]*t[s];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let s=0;for(let i=0;i<t.length;i++)s+=t[i]*e[i];return s}s.d(e,{$G:()=>n,MA:()=>r,hu:()=>i})},2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>n});var i=s(9976);class n extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,n)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,n)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new n({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in n.aaSynonyms?n.aaSynonyms[t]:t;return super.get(e)}}n.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return n.GrokGroups;case"lesk":return n.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",i="";for(const n of t)"("==n?e++:")"==n?e--:e?s+=n:i+=n;return isNaN(parseInt(s))?[i,s]:[i,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[i,n]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,n=n.length>6?`${n.slice(0,3)}...`:n,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,n,1]:[this.undefinedColor,i,n,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,n,2]:[this.undefinedColor,i,n,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,n,3]:[this.undefinedColor,i,n,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,n,4]:[this.undefinedColor,i,n,4]}return[this.undefinedColor,i,n,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>o,Xk:()=>r});var i=s(976),n=(s(4469),s(1047));function r(t){const e=[];for(let s=0;s<t.rowCount;s++){const i={};Object.keys(n.K4).forEach((e=>{if("symbol"===e){const r=t.get(n.K4[e],s);i[e]="."===r?t.get(n.At,s):r}else if("rgroups"===e){const r=t.get(n.K4[e],s).split("\n"),o=[];r.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===s?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else n.K4[e]&&(i[e]=t.get(n.K4[e],s))})),e.push(i)}return e}async function o(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}s(6066)},6375:(t,e,s)=>{"use strict";s.d(e,{i0:()=>d});var i=s(4469),n=s(976),r=s(1821),o=s(7767),a=s(499);const l={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var h=s(1047);function c(t){return Math.round(l.PRECISION_FACTOR*t)/l.PRECISION_FACTOR}function u(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?u(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}s(6e3);var m=s(8447);async function d(t,e,c){if(0===n.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==n.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${n.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let d=e;a.Cn.getOrCreate(e).isHelm()&&(d=new o.L(e).convert(r.r2.SEPARATOR,"."),d.name=e.name);const f=a.Cn.getOrCreate(d).alphabet;let g;if("PT"===f||"UN"===f)g="PEPTIDE";else{if("RNA"!==f&&"DNA"!==f)return{col:null,warnings:[`Unexpected column's '${d.name}' alphabet '${f}'.`]};g="RNA"}const y=function(t){const e=t.length,s=new Array(e),i=t.getTag(n.TAGS.UNITS),r=t.getTag("separator"),o=(0,m.vU)(i,r);for(let i=0;i<e;++i){const e=t.get(i);s[i]=e?o(e).filter((t=>""!==t)):[]}return s}(d),w=await async function(t,e,s,n){const r=function(t,e,s){const i=new Map;for(const n of t.getMonomerSymbolsByType(e)){const r=t.getMonomer(e,n);if("RNA"===e&&("Branch"===r.monomerType||"DNA"===s&&r.symbol===l.DEOXYRIBOSE||"RNA"===s&&r.symbol===l.RIBOSE||r.symbol===l.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==r.monomerType){const t={};h.rx.forEach((e=>{t[e]=r[e]})),i.set(r.symbol,t)}}return i}(e,s,n),o=new Map,a=await i.functions.call("Chem:getRdKitModule"),c={value:null};if("RNA"===s){const t="RNA"===n?[l.RIBOSE,l.PHOSPHATE]:[l.DEOXYRIBOSE,l.PHOSPHATE];for(const e of t)p(o,e,r,a,s,c)}for(let e=0;e<t.length;++e){const i=t[e];for(const t of i)if(""!==t)try{p(o,t,r,a,s,c)}catch(e){const s=u(e);throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n`+s),new Error(`Сan't get monomer '${t}' from library: ${s}`)}}return o}(y,c,g,f),b=d.length,{molfileList:v,molfileWarningList:C}=await async function(t,e,i,n,r){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:i,polymerType:n,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(y,w,f,g,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const S=`molfile(${d.name})`,M=t.columns.getUnusedName(S),A=n.Column.fromStrings(M,v);return A.semType=n.SEMTYPE.MOLECULE,A.setTag(n.TAGS.UNITS,n.UNITS.Molecule.MOLBLOCK),{col:A,warnings:C}}function p(t,e,s,i,n,r){if(!t.has(e)){const o=function(t,e,s,i,n){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let s=t.indexOf(l.V2K_A_LINE,0),i=s;for(;-1!==s;){i=t.indexOf("\n",s);const n=parseInt(t.substring(s,i).replace(/^A\s+/,""));s=t.indexOf("R",i),i=t.indexOf("\n",s);const r=parseInt(t.substring(s,i).replace(/^R/,""));e.set(n,r),s=t.indexOf(l.V2K_A_LINE,i)}for(s=t.indexOf(l.V2K_RGP_LINE,0),i=t.indexOf("\n",s);-1!==s;){s+=l.V2K_RGP_SHIFT,i=t.indexOf("\n",s);const n=t.substring(s,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<n.length;t+=2){if(e.has(n[t])&&e.get(n[t])!==n[t+1])throw new Error(`r-group index ${n[t]} has already been added with a different value`);e.set(n[t],n[t+1])}s=t.indexOf(l.V2K_RGP_LINE,i)}return e}(r.molfile),h=function(t,e){const s=e.get_mol(t),i=s.get_v3Kmolblock();return s.delete(),i}(function(t){let e=t.indexOf(l.V2K_A_LINE,0);-1===e&&(e=t.indexOf(l.V2K_RGP_LINE));const s=t.indexOf(l.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),u=function(t){let e=(t=t.replaceAll("\r","")).indexOf(l.V3K_BEGIN_COUNTS_LINE)+l.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,s))}}(h),m=function(t,e){const s=new Array(e),i=new Float32Array(e),n=new Float32Array(e),r=new Array(e);let o=t.indexOf(l.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let a=o;for(let h=0;h<e;h++){o=t.indexOf(l.V3K_BEGIN_DATA_LINE,o)+l.V3K_IDX_SHIFT,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),s[h]=t.substring(o,a);const e=new Array(2);for(let s=0;s<2;++s)o=a+1,a=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,a));i[h]=e[0],n[h]=e[1],o=a,a=t.indexOf("\n",o)+1,r[h]=t.slice(o,a),o=a}return{atomTypes:s,x:i,y:n,kwargs:r}}(h,u.atomCount),d=function(t,e){const s=new Uint32Array(e),i=new Array(e),n=new Map,r=new Map;let o=t.indexOf(l.V3K_BEGIN_BOND_BLOCK);o=t.indexOf("\n",o);let a=o;for(let h=0;h<e;++h){const e=new Array(3);o=t.indexOf(l.V3K_BEGIN_DATA_LINE,a)+l.V3K_IDX_SHIFT,a=t.indexOf(" ",o);for(let s=0;s<3;++s)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[s]=parseInt(t.slice(o,a));s[h]=e[0],i[h]=e.slice(1);const c=t.indexOf("\n",o);let u=t.slice(a,c),m=u.indexOf(l.V3K_BOND_CONFIG);if(-1!==m){m=u.indexOf("=",m)+1;let t=u.indexOf(" ",m);-1===t&&(t=u.length);const e=parseInt(u.slice(m,t));n.set(h,e);const s=l.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||r.set(h,u)}return{bondTypes:s,atomPairs:i,bondConfiguration:n,kwargs:r}}(h,u.bondCount),p={atoms:m,bonds:d,meta:f(m,d,o,a)};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;A(t,-i[e],-n[e]);const r=C(i[s],n[s]);S(t.atoms,-r),i[t.meta.rNodes[1]-1]<0&&function(t){M(t,!1)}(t);const o=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=s[t],n=s[(t+1)%2];e.has(i)?e.get(i)?.push(n):e.set(i,new Array(1).fill(n))}return e}(t);let s=0,i=0;for(;0===s;){const n=e.get(t.meta.terminalNodes[1])[i];t.atoms.atomTypes[n-1]===l.OXYGEN&&n!==t.meta.rNodes[1]&&(s=n),i++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){M(t,!0)}(t),S(t.atoms,-function(t,e){return C(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const i=e-1,n=s-1,r=t.atoms.x,o=t.atoms.y,a=r[i],l=o[i];r[i]=r[n],o[i]=o[n],r[n]=a,o[n]=l}(t,e,t.meta.rNodes[1])}(t,o)}(p):t===l.RIBOSE||t===l.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,i=t.atoms.y;let n=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;A(t,-s[n],-i[n]);const o=C(s[r],i[r]);S(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,i=t.meta.rNodes[2]-1,n=t.meta.terminalNodes[2]-1,r=e[i]-e[n],o=s[i]-s[n];return Math.atan(o/r)+Math.PI/2}(t),n=t.meta.terminalNodes[0]-1,A(t,-s[n],-i[n])}(p,n):t===l.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;A(t,-i[e],-n[e]);const r=C(i[s],n[s]);S(t.atoms,Math.PI/2-r)}(p):function(t,e){const s=t.atoms.x,i=t.atoms.y,n=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;A(t,-s[n],-i[n]);const o=C(s[r],i[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(t.atoms,Math.PI-o+a);const l=function(t,e){return c(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:s[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:s[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=l)for(let t=0;t<s.length;++t)s[t]=c(s[t]/l),i[t]=c(i[t]/l)}(p,n),function(t,e,s){"PEPTIDE"===t?(y(e,t),b(e,e.meta.rNodes[1])):s===l.RIBOSE||s===l.DEOXYRIBOSE?(b(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],g(e.bonds,e.meta),y(e,t),b(e,e.meta.rNodes[1]),b(e,e.meta.rNodes[0]),b(e,e.meta.rNodes[2])):s===l.PHOSPHATE&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],A(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),y(e,t),b(e,e.meta.rNodes[1]))}(i,p,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===l.HYDROGEN&&(b(t,e+1),--e),++e}(p),p}return null}(e,s,i,n,r);if(!o)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);t.set(e,o)}}function f(t,e,s,i){const n={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(t,e,s){for(const[i,n]of s)t.atomTypes[i-1]=e[n-1]}(t,s,i),function(t,e){e.rNodes=Array.from(t.keys());for(let s=0;s<e.rNodes.length;s++)for(const i 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m.J.Chromatogram;default:return d.UE.Color}}function E(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},7767:(t,e,s)=>{"use strict";s.d(e,{L:()=>l});var i=s(6414),n=s.n(i),r=s(499),o=s(1821),a=s(6066);class l extends r.Cn{get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,i){i||(i=this.toFasta(e)?r._9[o.r2.FASTA]:r._9[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const n=/(R\(|D\(|\)|P)/g,a=t.startsWith("DNA")||t.startsWith("RNA"),l=this.splitter(t),h=[];for(let t=0;t<l.length;t++){let s=l[t];if(a&&(s=s.replace(n,"")),s===r._9[o.r2.HELM])h.push(i);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";h.push(t)}else h.push(s)}return h.join(s)}convert(t,e){const s=this.getConverter(t,e),i=this.getNewColumn(t,e);return i.init((t=>s(this.column.get(t)))),i}constructor(t){super(t),this._splitter=null}getConverter(t,e=null){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?c(t,e):t.getSplitter()(e),i=new Array(s.length);for(const[e,a]of n().enumerate(s)){let n=e;t.isHelm()&&(n=e.replace(h,"$1")),t.isGap(n)?n=r._9[o.r2.FASTA]:n.length>1&&(n="["+s[a]+"]"),i[a]=n}return i.join("")}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA"),i=e.startsWith("RNA"),[n,a,l,c]=t.getHelmWrappers();return`${n}${t.getSplitter()(e).map((e=>{let n=e;return n=t.isGap(n)?r._9[o.r2.HELM]:s||i?n.replace(h,"$1"):1==e.length?`${a}${e}${l}`:`${a}[${e}]${l}`,n})).join(".")}${c}`}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const i=t.isHelm()?c(t,e):t.getSplitter()(e),a=new Array(i.length);e.startsWith("PEPTIDE");for(const[e,s]of n().enumerate(i)){let i=e;t.isGap(i)&&(i=r._9[o.r2.SEPARATOR]),a[s]=i}return a.filter((t=>null!==t)).join(s)}(s,t,e)};throw new Error}}const h=/[RD]\((\w)\)P?/g;function c(t,e){const s=t.getSplitter()(e),i=new Array(s.length),r=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of n().enumerate(s)){let s=t;(r||o)&&(s=s.replace(h,"$1"),s="P"===s?null:s),i[e]=s}return i.filter((t=>null!==t))}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>c,_9:()=>h});var i=s(976),n=s(1821),r=s(6066),o=s(489),a=s(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}},h={[n.r2.FASTA]:"-",[n.r2.SEPARATOR]:"",[n.r2.HELM]:"*"};class c{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.FASTA)throw new Error(`The column of notation '${n.r2.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,n.r2.FASTA),c.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.SEPARATOR)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(i.TAGS.UNITS,n.r2.SEPARATOR),t.column.setTag("separator",e),c.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${n.r2.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,n.r2.HELM),c.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[n.r2.FASTA,n.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");const e=s.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const i=(0,r.w4)(s.freq,n.XS);if(t.column.setTag("alphabet",i),"UN"===i){const e=Object.keys(s.freq).length,i=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===n.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==n.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===n.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),i=this._column.categories;for(let n=0;n<e;n++){const e=i[s[n]];this._splitted[n]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const i of this.splitted){null==s?s=i.length:i.length!==s&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return this.notation===n.r2.FASTA}isSeparator(){return this.notation===n.r2.SEPARATOR}isHelm(){return this.notation===n.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===n.r2.FASTA&&t===h.FASTA||this.units===n.r2.HELM&&t===h.HELM}getNotation(){if(this.units.toLowerCase().startsWith(n.r2.FASTA))return n.r2.FASTA;if(this.units.toLowerCase().startsWith(n.r2.SEPARATOR))return n.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(n.r2.HELM))return n.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,r=s.length,o=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(o),l=i.Column.fromList("string",a,new Array(r).fill(""));if(l.semType=i.SEMTYPE.MACROMOLECULE,l.setTag(i.TAGS.UNITS,t),t===n.r2.SEPARATOR){if(!e)throw new Error(`Notation '${n.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==n.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=c.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[n.r2.FASTA,n.r2.SEPARATOR,n.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!c.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const n=i.Column.fromList("string",e,new Array(t).fill(""));return n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,s),n}getSplitter(){return(0,r.Mj)(this._column)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,r.Ar)(this.separator);for(const t of this.column.categories){const i=s(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}constructor(t){if(this._splitted=null,this._stats=null,t.type!=i.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${i.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h[n.r2.FASTA]:this.isHelm()?h[n.r2.HELM]:h[n.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())c.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");c.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);c.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new c(t)),t.temp[l.uhTemp]}}},9298:(t,e,s)=>{"use strict";var i,n,r,o,a,l;s.d(e,{CI:()=>c,Ct:()=>l,DX:()=>i,ES:()=>n,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.positionNames=".wl.positionNames",t.positionLabels=".wl.positionLabels",t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new 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n=t.get(i,s)/t.get(e,s);t.set(i,s,0);for(let r=s+1;r<t.columns;r++)t.set(i,r,t.get(i,r)-t.get(e,r)*n)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,i=s-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let n=0,r=!1;for(;n<s&&!1===r;)1===t.get(i,n)?r=!0:n++;for(let s=0;s<i;s++){let r=t.get(s,n);for(let o=n;o<e;o++){let e=t.get(s,o)-r*t.get(i,o);t.set(s,o,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let i=new N(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let 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this}subRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){w(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){b(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)>t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)<t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}maxRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),s[1]=i);return s}minRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){w(this,t),T(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),s[1]=i);return s}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),s[0]=i);return s}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),s[0]=i);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let i=0;i<e.length;i++)s+=e[i]*t[i];return s}mmul(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.columns,n=new N(e,i),r=new Float64Array(s);for(let o=0;o<i;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let i=0;i<s;i++)e+=this.get(t,i)*r[i];n.set(t,o,e)}}return n}strassen2x2(t){t=N.checkMatrix(t);let e=new N(2,2);const s=this.get(0,0),i=t.get(0,0),n=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(i+h),u=(o+l)*i,m=s*(r-h),d=l*(a-i),p=(s+n)*h,f=c+d-p+(n-l)*(a+h),g=m+p,y=u+d,w=c-u+m+(o-s)*(i+r);return e.set(0,0,f),e.set(0,1,g),e.set(1,0,y),e.set(1,1,w),e}strassen3x3(t){t=N.checkMatrix(t);let e=new N(3,3);const s=this.get(0,0),i=this.get(0,1),n=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),p=t.get(1,0),f=t.get(1,1),g=t.get(1,2),y=t.get(2,0),w=t.get(2,1),b=t.get(2,2),v=(s-r)*(-m+f),C=(-s+r+o)*(u-m+f),S=(r+o)*(-u+m),M=s*u,A=(-s+l+h)*(u-d+g),T=(-s+l)*(d-g),E=(l+h)*(-u+d),x=(-n+h+c)*(f+y-w),L=(n-c)*(f-w),I=n*y,_=(h+c)*(-y+w),R=(-n+o+a)*(g+y-b),k=(n-a)*(g-b),O=(o+a)*(-y+b),P=M+I+i*p,G=(s+i+n-r-o-h-c)*f+C+S+M+x+I+_,F=M+A+E+(s+i+n-o-a-l-h)*g+I+R+O,W=v+o*(-u+m+p-f-g-y+b)+C+M+I+R+k,V=v+C+S+M+a*w,H=I+R+k+O+r*d,D=M+A+T+h*(-u+d+p-f-g-y+w)+x+L+I,B=x+L+I+_+l*m,Z=M+A+T+E+c*b;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,D),e.set(2,1,B),e.set(2,2,Z),e}mmulStrassen(t){t=N.checkMatrix(t);let e=this.clone(),s=e.rows,i=e.columns,n=t.rows,r=t.columns;function o(t,e,s){let i=t.rows,n=t.columns;if(i===e&&n===s)return t;{let i=E.zeros(e,s);return i=i.setSubMatrix(t,0,0),i}}i!==n&&console.warn(`Multiplying ${s} x ${i} and ${n} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,n),l=Math.max(i,r);return e=o(e,a,l),function t(e,s,i,n){if(i<=512||n<=512)return e.mmul(s);i%2==1&&n%2==1?(e=o(e,i+1,n+1),s=o(s,i+1,n+1)):i%2==1?(e=o(e,i+1,n),s=o(s,i+1,n)):n%2==1&&(e=o(e,i,n+1),s=o(s,i,n+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),f=s.subMatrix(r,s.rows-1,a,s.columns-1),g=t(E.add(l,p),E.add(h,f),r,a),y=t(E.add(m,p),h,r,a),w=t(l,E.sub(u,f),r,a),b=t(p,E.sub(d,h),r,a),v=t(E.add(l,c),f,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(d,f),r,a),M=E.add(g,b);M.sub(v),M.add(S);let A=E.add(w,v),T=E.add(y,b),x=E.sub(g,y);x.add(w),x.add(C);let N=E.zeros(2*M.rows,2*M.columns);return N=N.setSubMatrix(M,0,0),N=N.setSubMatrix(A,M.rows,0),N=N.setSubMatrix(T,0,M.columns),N=N.setSubMatrix(x,M.rows,M.columns),N.subMatrix(0,i-1,0,n-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.rows;t++){const n=this.getRow(t);n.length>0&&m(n,{min:e,max:s,output:n}),i.setRow(t,n)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.columns;t++){const n=this.getColumn(t);n.length&&m(n,{min:e,max:s,output:n}),i.setColumn(t,n)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),i=this.get(e,this.columns-1-s);this.set(e,s,i),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),i=this.get(this.rows-1-s,e);this.set(s,e,i),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.rows,n=t.columns,r=new N(e*i,s*n);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<i;s++)for(let a=0;a<n;a++)r.set(i*o+s,n*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=N.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,i=this.kroneckerProduct(N.eye(s,s)),n=N.eye(e,e).kroneckerProduct(t);return i.add(n)}transpose(){let t=new N(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,i){S(this,t,e,s,i);let n=new N(e-t+1,i-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=i;e++)n.set(r-t,e-s,this.get(r,e));return n}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let i=new N(t.length,s-e+1);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.rows)throw new RangeError(`Row index out of range: ${t[n]}`);i.set(n,r-e,this.get(t[n],r))}return i}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let i=new N(s-e+1,t.length);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.columns)throw new RangeError(`Column index out of range: ${t[n]}`);i.set(r-e,n,this.get(r,t[n]))}return i}setSubMatrix(t,e,s){if((t=N.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let i=0;i<t.rows;i++)for(let n=0;n<t.columns;n++)this.set(e+i,s+n,t.get(i,n));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new N(t.length,e.length);for(let i=0;i<t.length;i++){let n=t[i];for(let t=0;t<e.length;t++){let r=e[t];s.set(i,t,this.get(n,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new N(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]+=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]+=t.get(s,i);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e+=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]*=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]*=t.get(s,i);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e*=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(o,e)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,o)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,s){const i=t.rows,n=t.columns,r=i*n;let o=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<n;i++)l=t.get(e,i)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[i])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[i])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let i=0;i<t.columns;i++)for(let n=0;n<t.rows;n++)s+=Math.pow(t.get(n,i),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return f(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return f(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class N extends E{constructor(t,e){if(super(),N.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(s[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[i]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return w(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),w(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let i=0;i<t;i++)s[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)s[i-1]=this.data[e][i];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let s=0;s<this.rows;s++){const i=new Float64Array(this.columns+1);let n=0;for(;n<t;n++)i[n]=this.data[s][n];for(i[n++]=e[s];n<this.columns+1;n++)i[n]=this.data[s][n-1];this.data[s]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,N);class L extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class I{constructor(t){let e,s,i,n,r,o,a,l,h,c=(t=L.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),p=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,i=0;i<h;i++)r+=c.get(e,i)*l[i];l[e]-=r,c.set(e,s,l[e])}for(n=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[n])&&(n=e);if(n!==s){for(i=0;i<m;i++)o=c.get(n,i),c.set(n,i,c.get(s,i)),c.set(s,i,o);a=d[n],d[n]=d[s],d[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=N.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,i,n,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(n=0;n<a;n++)for(s=n+1;s<a;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n));for(n=a-1;n>=0;n--){for(i=0;i<r;i++)o.set(n,i,o.get(n,i)/e.get(n,n));for(s=0;s<n;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let i=0;i<s;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n>e?i.set(n,e,t.get(n,e)):n===e?i.set(n,e,1):i.set(n,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n<=e?i.set(n,e,t.get(n,e)):i.set(n,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,i,n,r=(t=L.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<o;e++)t=_(t,r.get(e,i));if(0!==t){for(r.get(i,i)<0&&(t=-t),e=i;e<o;e++)r.set(e,i,r.get(e,i)/t);for(r.set(i,i,r.get(i,i)+1),s=i+1;s<a;s++){for(n=0,e=i;e<o;e++)n+=r.get(e,i)*r.get(e,s);for(n=-n/r.get(i,i),e=i;e<o;e++)r.set(e,s,r.get(e,s)+n*r.get(e,i))}}l[i]=-t}this.QR=r,this.Rdiag=l}solve(t){t=N.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,n,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(n=0;n<a;n++){for(o=0,i=r;i<s;i++)o+=e.get(i,r)*l.get(i,n);for(o=-o/e.get(r,r),i=r;i<s;i++)l.set(i,n,l.get(i,n)+o*e.get(i,r))}for(r=h-1;r>=0;r--){for(n=0;n<a;n++)l.set(r,n,l.get(r,n)/this.Rdiag[r]);for(i=0;i<r;i++)for(n=0;n<a;n++)l.set(i,n,l.get(i,n)-l.get(r,n)*e.get(i,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,i=s.columns,n=new N(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?n.set(t,e,s.get(t,e)):t===e?n.set(t,e,this.Rdiag[t]):n.set(t,e,0);return n}get orthogonalMatrix(){let t,e,s,i,n=this.QR,r=n.rows,o=n.columns,a=new N(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==n.get(s,s)){for(i=0,t=s;t<r;t++)i+=n.get(t,s)*a.get(t,e);for(i=-i/n.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+i*n.get(t,s))}}return a}}class k{constructor(t,e={}){if((t=L.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,i=t.columns;const{computeLeftSingularVectors:n=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(n),h=Boolean(r),c=!1;if(s<i)if(o){a=t.transpose(),s=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,i),m=Math.min(s+1,i),d=new Float64Array(m),p=new N(s,u),f=new N(i,i),g=new Float64Array(i),y=new Float64Array(s),w=new Float64Array(m);for(let t=0;t<m;t++)w[t]=t;let b=Math.min(s-1,i),v=Math.max(0,Math.min(i-2,s)),C=Math.max(b,v);for(let t=0;t<C;t++){if(t<b){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<i;e++){if(t<b&&0!==d[t]){let i=0;for(let n=t;n<s;n++)i+=a.get(n,t)*a.get(n,e);i=-i/a.get(t,t);for(let n=t;n<s;n++)a.set(n,e,a.get(n,e)+i*a.get(n,t))}g[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<v){g[t]=0;for(let e=t+1;e<i;e++)g[t]=_(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<s&&0!==g[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<i;s++)y[e]+=g[s]*a.get(e,s);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let n=t+1;n<s;n++)a.set(n,e,a.get(n,e)+i*y[n])}}if(h)for(let e=t+1;e<i;e++)f.set(e,t,g[e])}}let S=Math.min(i,s+1);if(b<i&&(d[b]=a.get(b,b)),s<S&&(d[S-1]=0),v+1<S&&(g[v]=a.get(v,S-1)),g[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let i=0;for(let n=t;n<s;n++)i+=p.get(n,t)*p.get(n,e);i=-i/p.get(t,t);for(let n=t;n<s;n++)p.set(n,e,p.get(n,e)+i*p.get(n,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<v&&0!==g[t])for(let e=t+1;e<i;e++){let s=0;for(let n=t+1;n<i;n++)s+=f.get(n,t)*f.get(n,e);s=-s/f.get(t+1,t);for(let n=t+1;n<i;n++)f.set(n,e,f.get(n,e)+s*f.get(n,t))}for(let e=0;e<i;e++)f.set(e,t,0);f.set(t,t,1)}let M=S-1,A=0,T=Number.EPSILON;for(;S>0;){let 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i=s(4469),n=s(3870),r=s(976),o=s(6066);const a="rgb(100,100,100)",l="#808080",h="rgb(0,0,0)",c=o.GU;var u;function m(t,e,s,i,n,r,o=a,m=0,d=!1,p=1,f="",g=!1,y=u.classic,w=[],b=0,v=null,C=[],S=null,M={}){n.textAlign="start";let A=r.substring(0),T=g?"":f;y===u.MSA&&(T="");let E=!0,x=!0,N="difference";null!=v&&null!=v.cell.column&&(E=v.cell.column.temp["color-code"]??!0,x=v.cell.column.temp["compare-with-current"]??!0,N=v.cell.column.temp["highlight-difference"]??"difference");const L=C[b];x&&C.length>0&&"difference"===N&&(p=A==L?.3:p),x&&C.length>0&&"equal"===N&&(p=A!=L?.3:p),null!=S&&(A=c(A,S));const I=A+T;M[I]??(M[I]=n.measureText(I));let _=M[I];M[A]??(M[A]=n.measureText(A));let R=M[A].width;M[T]??(M[T]=n.measureText(T));const k=M[T].width,O=i/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,i){const 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230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[n.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const n={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=i.chem.svgMol(e.smiles,void 0,void 0,n);r.push(o),s._monomerStructureMap[t]=o}}n.tooltip.show(n.divV(r),e.x+16,e.y+16)}else n.tooltip.hide()}render(t,e,s,i,n,o,a){let l=0,h=999;const c=o.grid,d=o.cell.column,p=d.temp,y=p["monomer-width"];"short"===(null!=y?y:"short")&&(h=p[".mm.cellRenderer.maxMonomerLength"]??Ce.properties.MaxMonomerLength);let M=d.temp["bio-seqCol"];M||(M=new f.A(c,d,(()=>{const t=w.Cn.getOrCreate(d);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:l,monomerToShort:C,monomerLengthLimit:h,monomerLib:xe()}}))),d.tags[".mm.cellRenderer.settingsChanged"]===b.true&&(l=p[".mm.cellRenderer.gapLength"]??l,M.setMonomerLengthLimit(h),M.setSeparatorWidth(M.isMsa()?8:l),d.setTag(".mm.cellRenderer.settingsChanged",b.false));const[A,T]=M.getCellMonomerLengths(o.tableRowIndex);A.length,M.updated&&(p["bio-seqCol"]=M),t.save();try{const a=-1!==o.gridRow?o.grid:null,l=o.cell.value,c=d.getTag("alphabet"),f=50;i=S(a,t,e,i),t.beginPath(),t.rect(e+this.padding,s+this.padding,i-this.padding-1,n-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=d.getTag(r.TAGS.UNITS),w=d.getTag("aligned"),b=(0,g.py)(c),C=d.getTag("separator")??"",A=i/5,E=(0,g.vU)(y,C,A),x=p["reference-sequence"],N=p["current-word"],L=E(null!=x&&""!=x?x:N??""),I=E(l);let _=v,R=u.classic;w&&w.includes("MSA")&&y==g.r2.SEPARATOR&&(R=u.MSA);for(const[r,a]of I.entries()){_=b.get(a),t.fillStyle=v;const l=r===I.length-1;if(m(e+this.padding,s,i,n,t,a,_,0,!0,1,C,l,R,T,r,o,L,h,M._monomerLengthMap),f>i)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";Ce.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class T extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return p.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,i,n,o,a){const l=o.grid,h=o.cell.value??"",c=o.tableColumn.tags.separator,u=o.tableColumn.tags[r.TAGS.UNITS];i=S(l,t,e,i);const[m,d]=h.split("#"),p=(0,g.vU)(u,c);E(t,e,s,i,n,p(m),p(d),u)}}function E(t,e,s,i,n,r,o,a,l,h){if(r.length!==o.length){const t=function(t,e){let s=0,i=0;const n=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)n[t]===r[t]&&s++;const o=n.length-r.length;for(let t=n.length-1;t>o;t--)n[t]===r[t-o]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(r,o);r=t.subParts1,o=t.subParts2}const c=t.measureText(M(r).join("")),u=t.measureText(M(o).join("")),d=Math.max(c.width,u.width);l&&(i=d+4*r.length,t.canvas.width=d+4*r.length);let p=Math.max(e,e+(i-(d+4*r.length))/2)+5;const f=Math.max(s,s+(n-28)/2);t.save(),t.beginPath(),t.rect(e,s,l?d+4*r.length:i,n),t.clip(),t.font="12px monospace",t.textBaseline="top";let w=y.UE.Color;"HELM"!=a&&(w=(0,g.py)(a.substring(a.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],l=w.get(s);if(s!=a){const r=w.get(a),o=m(p,f-7,i,n,t,s,l,0,!0),c=m(p,f+7,i,n,t,a,r,0,!0);p=Math.max(c,o),h&&(h[e]=x(s,a,l,r,f,7,n))}else p=m(p,f,i,n,t,s,l,0,!0,.5);p+=4}t.restore()}function x(t,e,s,i,n,r,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(M([t]).join("")).width,c=l.measureText(M([e]).join("")).width,u=Math.max(h,c);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",m(0,n-r,u,o,l,t,s,0,!0),m(0,n+r,u,o,l,e,i,0,!0),a}var N,L=s(701),I=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(N||(N={})),new class{constructor(){this.regionTypes=[N.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=I.ES.Entropy}};var _=s(833);const R=N;class k extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.regionTypes=this.stringList("regionTypes",[R.CDR],{choices:Object.values(R).filter((t=>t!=R.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16,{editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position. A value of zero means autofit to the width."}),this.positionHeight=this.string("positionHeight",I.ES.Entropy,{choices:Object.keys(I.ES)})}async init(){this.subs.push((0,L.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,Ce.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ce.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){Ce.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&n.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Ce.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<s.length;t++)for(const n of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==n));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,n,e]})())}const r=await Promise.all(i);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s;this.mainLayout=n.table(this.chains,(t=>[...s.length>0?[n.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",n.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=n.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",n.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=n.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Ce.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Ce.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{const t=window.devicePixelRatio,e=(this.root.clientHeight-54)/this.chains.length,s=Math.min(e,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));let i=0;for(let t=0;t<this.logos.length;t++){for(const e of this.chains)this.logos[t][e].root.style.height=`${s}px`;i+=Math.max(...this.chains.map((e=>this.logos[t][e].Length)))}if(0===this.positionWidth&&this.logos.length>0&&i>0){const e=22,s=13,n=9,r=(this.root.clientWidth-e-(this.logos.length-1)*n-s)/i*t;for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const s=this.chains[e];this.logos[t][s].setOptions({positionWidth:r})}}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?I.Ct.Selected:I.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const i=this.chains[s];this.logos[e][i].setOptions({[_.bo.filterSource]:t})}}}var O=s(9017),P=s(7656),G=s(7983),F=s(7767),W=s(489);async function V(t){const e=new F.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=W.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(g.r2.FASTA);i=t.toList(),s=w.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<i.length;e++)i[e]=t.seqCol.isNone(e)?null:i[e];const n=await(0,P.I)(i,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,n.embedding[e])));return{distance:n.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,G.HV)(t.seqCol,!1),await i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function H(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var D=s(5697),B=s(3379),Z=s.n(B),U=s(7795),Y=s.n(U),z=s(569),X=s.n(z),q=s(3565),K=s.n(q),$=s(9216),j=s.n($),J=s(4589),Q=s.n(J),tt=s(9414),et={};et.styleTagTransform=Q(),et.setAttributes=K(),et.insert=X().bind(null,"head"),et.domAPI=Y(),et.insertStyleElement=j(),Z()(tt.Z,et),tt.Z&&tt.Z.locals&&tt.Z.locals;var st=s(3914),it=s(6254);let nt=0;const rt="cliffsDf",ot=new L.Subject,at="act_diff",lt="sali",ht="sim",ct="line_index",ut=["1_seq","2_seq"],mt="filterCliffs";function dt(t,e,s){const i=e.getBoundingClientRect(),n=t.clientX-i.left,r=t.clientY-i.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-n,t.a[1]-r)+Math.hypot(t.b[0]-n,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var pt=s(1040);async function ft(t,e,s,n,o){e.version!==e.temp["last-invalidated-version"]&&await(0,G.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(n).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:n,simArr:o})}function gt(t){const e=n.divH([]),s=n.divV([n.divText(t.seqCol.name),n.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,i)=>{const r=n.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(n.divV([n.divText(t.seqCol.get(s)),r]))})),e}function yt(t){const e=n.div();e.append(n.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),i=new Array(2);t.line.mols.forEach(((e,n)=>{s[n]=t.seqCol.get(e),i[n]=t.activityCol.get(e)}));const o={},a=t.seqCol.getTag(r.TAGS.UNITS),l=t.seqCol.getTag("separator"),h=(0,g.vU)(a,l),c=bt(h(s[0]),h(s[1]),a,o);return e.append(n.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(vt(o)),e.append(wt("Activity delta",Math.abs(i[0]-i[1]))),e.append(wt("Cliff",t.sali)),e}function wt(t,e){return n.divH([n.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),n.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function bt(t,e,s,i){const n=document.createElement("canvas"),r=n.getContext("2d");return n.height=30,E(r,0,0,0,30,t,e,s,!0,i),n}function vt(t){const e=n.div();if(Object.keys(t).length>0){const s=n.divV([]);s.append(n.divH([n.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),n.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(n.divH([n.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function Ct(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}s(7861);var St=s(4004),Mt=s(7228),At=s(6375),Tt=s(5226);s(9133);class Et extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",D.kg[0],{choices:D.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(n.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var xt=s(7241),Nt=s(4293),Lt=s(2669);async function It(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=w.Cn.getOrCreate(t).getDistanceFunctionName(),i=new Lt.m(!0,!1),n=await i.calc(e,s);return i.terminate(),n}function _t(t){return(e,s)=>{const i=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?i(e,s):i(s,e)}}class Rt extends Et{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new L.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=w.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const n=s.plot.grid();n.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));n.cell("score",o).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Nt.Y)(this.root,n.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xt.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await It(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=w.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*i.length/o),u=s===a.length-1?Math.floor((s+1)*i.length/o):i.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:n}})=>{t?o(t):(h=Math.min(h,i),c=Math.max(c,n),l.set(e,r),s())},t.postMessage({fnName:n,values:i,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=_t(e),n=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,s)]:1-t[s]})));n.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=n.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=n.div(),s={},o=this.molCol?.name,a=t.col(o).getTag(r.TAGS.UNITS),l=t.col(o).getTag("separator"),h=(0,g.vU)(a,l),c=h(this.moleculeColumn.get(this.targetMoleculeIdx)),u=h(t.get(o,t.currentRowIdx)),m=bt(c,u,a,s);e.append(n.div(m,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&e.append(n.divV([n.divText("Different sequence length:",{style:{fontWeight:"bold"}}),n.divText(`target: ${c.length} monomers`),n.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(vt(s));const d=n.accordion(),p=n.element("i");p.className="grok-icon svg-icon svg-view-layout",d.addTitle(n.span([p,n.label("Similarity search")])),d.addPane("Differences",(()=>e),!0),i.shell.o=d.root}}var kt=s(8518);class Ot extends Et{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new L.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=w.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const i=r.DataFrame.fromColumns([s]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Nt.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xt.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await It(this.moleculeColumn),e=this.moleculeColumn.length,s=_t(e);this.renderMolIds=(0,kt.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[s(e,i)]))}}var Pt=s(9943),Gt=s(4413),Ft=s(1061),Wt=s(1345),Vt=s(116);const Ht={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Dt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=n.inputs([]),this.methodsParams={[Vt.AL.UMAP]:new Vt.bD,[Vt.AL.T_SNE]:new Vt.aP},this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=n.columnInput(Ht[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=n.choiceInput("Method",Vt.AL.UMAP,[Vt.AL.UMAP,Vt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=n.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):n.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=n.inputs([]);let e=!1;this.similarityMetricInput=n.choiceInput("Similarity",pt.gk.Tanimoto,D.Rt)}createAlgorithmSettingsDiv(t,e){return n.empty(t),Object.keys(e).forEach((s=>{const i=e[s],r=n.floatInput(i.uiName,i.value,(()=>{i.value=r.value}));n.tooltip.bind(r.root,i.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=n.columnInput(Ht[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),n.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Bt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=n.boolInput("Plot Embeddings",!0),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Zt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=n.intInput("Similarity cutoff",80),n.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),n.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Ut,Yt=function(t,e,s,i){return new(s||(s=Promise))((function(n,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};class zt{constructor(t,e,s=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._stopStartBtn=n.button(n.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=n.button(n.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=n.button(n.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._closeBtn=n.button(n.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,zt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=n.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(n.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=n.iconFA("clock");this._isAutomatic||0===e&&(s=n.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const i=n.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=n.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=n.divH([s,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,n,""),(null===(e=null===(t=n.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Yt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,i,a),yield(0,Ft.gw)(a));const l=n.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=n.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return Yt(this,void 0,void 0,(function*(){const i=n.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,zt.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return Yt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Xt(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ce.logger.error(t.message,void 0,s)}zt.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Ut||(Ut={}));const qt="data/sample_FASTA_PT_activity.csv";var Kt=s(1811);async function $t(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function jt(){return await i.functions.call("Dendrogram:getDendrogramService",{})}const Jt="data/sample_FASTA_PT_activity.csv",Qt="sequence";var te=s(3336),ee=s.n(te);const se="data/sample_FASTA_PT_activity.csv";var ie=s(8341);const ne="samples/HELM.csv";var re=s(2568),oe=s(525);class ae{constructor(){this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Ce.name}.${this._funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:"sequence"});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class le{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=n.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=n.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=n.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var he=s(9900);class ce{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const ue=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},me={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class de{constructor(t){this.grid=t,this.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.grid.dart||!t.tableColumn||!t.isTableCell||"Monomer"!=t.tableColumn.semType)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new ce(Se().getBioLib()).getCappedRotatedMonomer(a,o),h=n.div(o),c=l?i.chem.svgMol(l,void 0,void 0,me):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return n.tooltip.show(n.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){const e=t.dataFrame.temp;return ue.tooltipHandlerTemp in e||(e[ue.tooltipHandlerTemp]=new de(t),t.temp=e),e[ue.tooltipHandlerTemp]}}class pe extends r.GridCellRenderer{get name(){return p.Of.MONOMER}get cellType(){return p.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,i,n,r,o){if(r.gridRow<0)return;de.getOrCreate(r.grid),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,g.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,g.GU)(l,6),e+i/2,s+n/2,i)}}class fe extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new L.Subject}}class ge extends r.Package{get properties(){return this._properties}set properties(t){this._properties=t}}class ye extends r.Widget{constructor(t){super(n.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=n.intInput("Max monomer length",Ce.properties.MaxMonomerLength,(t=>{Ce.properties.MaxMonomerLength=t})),e=n.boolInput("Tooltip WebLogo",Ce.properties.TooltipWebLogo,(t=>{Ce.properties.TooltipWebLogo=t})),s=n.choiceInput("Default Separator",Ce.properties.DefaultSeparator,[".","/","-"],(t=>{Ce.properties.DefaultSeparator=t}));this.root.appendChild(n.form([t,e,s]))}}var we=s(5362),be={};be.styleTagTransform=Q(),be.setAttributes=K(),be.insert=X().bind(null,"head"),be.domAPI=Y(),be.insertStyleElement=j(),Z()(we.Z,be),we.Z&&we.Z.locals&&we.Z.locals;class ve extends r.Widget{constructor(t){super(n.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=w.Cn.getOrCreate(this.seqCol),e=Ce.properties.TooltipWebLogo,s=this.seqCol.getTag(I.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Ce=new ge;function Se(){return Wt.NT.instance}let Me=null;class Ae{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Te(){let t;await Promise.all([(async()=>{await Wt.NT.instance.loadLibraries()})(),(async()=>{t=await i.functions.call("Chem:getRdKitModule")})(),(async()=>{const t=await Ce.getProperties(),e=new fe(t);Ce.properties=e})()]);const e=Wt.NT.instance.getBioLib(),s=[],n=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const i=r[e].replaceAll("#R","O "),o=t.get_mol(i),a=JSON.parse(o.get_descriptors()).CrippenClogP;n.push(a),o?.delete()}));const o=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=n[t]<o?"#4682B4":"#DC143C";Me=new Ae(a)}function Ee(t){const e=new ve(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();i.shell.error(e)})),e}function xe(){return Wt.NT.instance.getBioLib()}async function Ne(t){return(0,Wt.cf)()}function Le(t){const e=new ye(t);return e.init().then(),e}function Ie(){return new A}function _e(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=n.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:d.short,[d.short,d.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const i=n.intInput("Max monomer length",t.temp[".mm.cellRenderer.maxMonomerLength"]??Ce.properties.MaxMonomerLength,(e=>{t.temp[".mm.cellRenderer.maxMonomerLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));i.setTooltip(`The max length of monomer name displayed without shortening in '${d.short}' monomer width mode.`);const o=n.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));o.setTooltip("The size of margin between monomers (in pixels)");const a=n.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));a.setTooltip("Color code");const l=n.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const h=n.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip('When on, all sequences get rendered in the "diff" mode');const c=n.inputs([s,i,o,l,a,h]);return new r.Widget(c)}(t)}function Re(t){return function(t){const e=n.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let i=y.UE.Color;switch(s){case"DNA":case"RNA":i=(0,g.py)("DNA");break;case"PT":i=(0,g.py)("PT")}const o=new Map;let a=0;const l=w.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),h=l.length;l.filter((t=>t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),a=Math.max(a,e+1)})),a/=h;const c={},u=Array.from(o.entries());u.sort(((t,e)=>e[1]-t[1])),u.forEach((([t,e])=>{const s=e/h,r=i.get(t),o=n.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/a*50+"px";const l=n.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,c[t]=n.div([o,l],{classes:"macromolecule-cell-comp-analysis-value"})}));const m=n.tableFromMap(c);return Array.from(m.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(m),new r.Widget(e)}(t)}function ke(){return new A}function Oe(){return new T}function Pe(t,e,s,i,n){const r=new O.k(i,n,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function Ge(){return new _.OZ}function Fe(){return new k}function We(t){const e=new Zt(r.SEMTYPE.MACROMOLECULE);n.dialog({title:"Activity 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i=[],n=[],r=[],o=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){r.push(l),o.push(l+h+1),a.add(l),a.add(l+h+1),i.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));n.push(1!=c?t/(1-c):1/0)}}return{simVals:i,saliVals:n,n1:r,n2:o,cliffsMolIds:a}}(await async function(t,e,s,i){const n=t.categories,o=t.getRawData(),a=r.Column.string("seq",t.length).init((t=>n[o[t]])),l=r.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const i=(0,it.y)(t);for(let n=0;n<t-1;++n){const o=new Float32Array(t-n-1).fill(0);for(let s=n+1;s<t;++s){const t=i(n,s);o[s-n-1]=e[t]===r.FLOAT_NULL?0:(0,D.Om)(e[t])}s[n]=r.Column.fromFloat32Array("similarity",o)}}(h,e,c):c=await i(h,t,l,"seq",c),c}(M,R,k,g),S,h),P=function(t,e,s,i,n,o){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(o.get(s[t])>o.get(i[t])?a[s[t]]+=e[t]:a[i[t]]+=e[t]);return r.Column.fromList("double",`sali_${n[0].substring(n[0].lastIndexOf("_"))}`,a)}(M.length,O.saliVals,O.n1,O.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",i=t.columns.names().filter((t=>t.includes(s))).length+1,n=`${s}_${i}`;return r.Column.bool(n,t.rowCount).init((t=>e.has(t)))}(t,O.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(O.saliVals),V=.8/(F.max-F.min),H=i.shell.getTableView(t.name);H.grid.columns.byName(G.name).visible=!1;const B=H.addViewer(r.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),Z=B.getInfo().canvas,U=function(t,e,s,i,n){const o=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],i=t.n2[e];o[e]={id:e,mols:[s,i],selected:!1,a:[],b:[]}}const a=r.DataFrame.create(o.length);return ut.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(o[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),n),a.col(t).semType=i})),a.columns.addNewFloat(at).init((t=>Math.abs(s.get(o[t].mols[0])-s.get(o[t].mols[1])))),a.columns.addNewInt(ct).init((t=>t)),a.columns.addNewFloat(lt).init((e=>t.saliVals[e])),a.columns.addNewFloat(ht).init((e=>t.simVals[e])),a.name=`${rt}${nt}`,{lines:o,linesDf:a}}(O,e,h,d,p),Y=b?b(U.linesDf,ut).sort([lt],[!1]):U.linesDf.plot.grid().sort([lt],[!1]);t.temp[".cliffsDfGrid"]=Y;const z=n.button(`${U.linesDf.rowCount} cliffs`,(()=>{H.dockManager.dock(Y,"down",null,"Activity cliffs",C??.2)}));z.classList.add("scatter_plot_link","cliffs_grid"),B.root.append(z);const X=n.switchInput("Show only 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s=dt(i,Z,U.lines);s&&-1===t.mouseOverRowIdx&&n.tooltip.show(y({cashedData:E,line:s,df:t,seqCol:e,activityCol:h}),i.clientX,i.clientY)}),500)})),Z.addEventListener("mousedown",(function(e){T=!0;const s=dt(e,Z,U.lines);if(s&&-1===t.mouseOverRowIdx){e.ctrlKey?(s.selected=!s.selected,U.linesDf.selection.set(s.id,s.selected)):U.linesDf.currentRowIdx!==s.id&&(U.linesDf.currentRowIdx=s.id,t.currentRowIdx=s.mols[0],t.filter.set(0,!U.lines[0].selected),t.filter.set(0,U.lines[0].selected));const i=U.linesDf.getSortedOrder(Y.sortByColumns,Y.sortTypes);Y.scrollToCell(ut[0],i.indexOf(s.id))}})),B.onEvent("d4-before-draw-scene").subscribe((e=>{const s=function(t,e,s,i,n,r,o){const a=i.lines,l=t.getInfo().canvas.getContext("2d"),h=t.dataFrame.columns.byName(e),c=t.dataFrame.columns.byName(s);for(let e=0;e<a.length;e++){const s=t.worldToScreen(h.get(a[e].mols[0]),c.get(a[e].mols[0])),u=t.worldToScreen(h.get(a[e].mols[1]),c.get(a[e].mols[1]));a[e].a=[s.x,s.y],a[e].b=[u.x,u.y];const m=new Path2D;m.moveTo(a[e].a[0],a[e].a[1]);const d=a[e].selected?"255,255,0":"0,128,0",p=n[e]===1/0?1:.2+(n[e]-o)*r;l.strokeStyle=`rgba(${d},${p})`,l.lineWidth=a[e].id===i.linesDf.currentRowIdx?3:1,m.lineTo(a[e].b[0],a[e].b[1]),l.stroke(m)}return a}(B,a[0],a[1],U,O.saliVals,V,F.min);if(A){const t=s[U.linesDf.currentRowIdx];setTimeout((()=>{const{zoomLeft:e,zoomRight:s,zoomTop:i,zoomBottom:n}=function(t,e,s,i,n,r){const o=Math.abs(s-n),a=Math.abs(i-r),l=t/o,h=e/a,c=Math.min(l,h),u=t/c*5,m=e/c*5,d=(s<n?s:n)+o/2-u/2,p=(i>r?i:r)-a/2+m/2;return{zoomLeft:d,zoomRight:d+u,zoomTop:p,zoomBottom:p-m}}(B.viewport.width,B.viewport.height,B.dataFrame.get(a[0],t.mols[0]),B.dataFrame.get(a[1],t.mols[0]),B.dataFrame.get(a[0],t.mols[1]),B.dataFrame.get(a[1],t.mols[1]));B.zoom(e,i,s,n)}),300),A=!1}X.value?t.rows.match({[G.name]:!0}).filter():!0===X.enabled&&t.filter.setAll(!0,!1)})),B.addProperty("similarityLimit","double",S),x=function(){const t=n.accordion(),e=n.element("i");return e.className="grok-icon 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h=H(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],n=[];let r=0;for(let e=0;e<t.rowCount;e++)s.includes(i[e])&&(t.rows.removeAt(e-r),n.push(e),r+=1);return n}(c,e),m={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},d=s===Vt.AL.UMAP?1e5:15e3,p=s===Vt.AL.UMAP?5e3:2e3;if(t.rowCount>d)i.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>p))return f(await V(m));n.dialog().add(n.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await V(m);return t.close(),f(e)})).show()}function f(e){const s=e.coordinates;for(const e of s){const s=e.toList();u.forEach((t=>s.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>s[t])))}if(a)return i.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function Be(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,re.n)(e,"To Atomic Level"))return;const s=(await Se()).getBioLib(),o=await(0,At.i0)(t,e,s);null!==o.col&&(t.columns.add(o.col,!0),await i.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&i.shell.warning(n.list(o.warnings))}function Ze(){(0,oe.K)()}async function Ue(t=null,e=null){return(0,oe.K)({col:t,clustersCol:e})}async function Ye(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(w.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,re.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>w.Cn.getOrCreate(t).isMsa())),r=n.choiceInput("Column",i?i.name:t[0],t);n.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(n.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await s(t)})).show()}else o=e[0];o&&await s(o)}else i.shell.error("Current table does not contain sequences")}async function ze(t){(0,Mt.Xk)(t)}function Xe(t){return new Tt.i(t).importFasta()}function qe(t){return console.log(t),[]}function Ke(){const t=(0,Nt.m)();(0,St.O)(t)}function $e(){return new pe}async function je(t){const e=r.TaskBarProgressIndicator.create("Test detectMacromolecule..."),s=(await i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let n=0;const o=[];for(const a of s)try{const e=await i.dapi.files.readAsText(t+a.fullPath),s=r.DataFrame.fromCsv(e);for(const t of s.columns)await i.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{n+=1,e.update(100*n/s.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}function Je(t){const e=new le;n.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function Qe(t,e){await(0,he.n)(t,e)}function ts(t){const e=w.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function es(){return new Rt}function ss(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function is(){return new Ot}function ns(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function rs(){const t=(0,Nt.m)();(0,G.gQ)(t)}function os(){(0,Pt.C2)()}function as(){return new Gt.ST}async function ls(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new ae,e=await Ce.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(e),await t.init(e,"webLogoLargeApp")}finally{t.close()}}function hs(t,e){!function(t,e){const s=w.Cn.getOrCreate(t.column),n=Object.values(g.r2).filter((t=>t!==s.units));e.group("Copy").items(n,(e=>{const s=new F.L(t.column),n=e===g.r2.SEPARATOR?Ce.properties.DefaultSeparator:void 0,r=s.getConverter(e,n)(t.value);navigator.clipboard?(navigator.clipboard.writeText(r),i.shell.info(`Value of notation '${e}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function cs(){await async function(){let t,e;try{const s=new zt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ce.files.readCsv(qt),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){Xt(t)}}()}async function us(){await async function(){let t,e,s,n,o;try{const a=new zt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[n,t,e]=await Promise.all([Ce.files.readCsv(Jt),$t(),jt()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,i){let n;{const t=Object.values(Ut);for(let s=0;s<t.length;s++){const i=t[s];if(!e.col(i)){const n=s==t.length-1;e.columns.add(r.Column.float(i,e.rowCount),n)}}if(e.rowCount>=1){const i=e.getCol(s).toList(),n=Date.now();Ce.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,P.I)(i,"UMAP",pt.W.Levenshtein,{}),o=Date.now();Ce.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-n)/1e3} s`);for(let s=0;s<t.length;s++){const i=t[s],n=e.getCol(i),o=r.embedding[s];n.init((t=>o[t]))}const a=Date.now();Ce.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}n=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Ut.X,yColumnName:Ut.Y,lassoTool:!0})}return t.dockManager.dock(n,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),n}(s,n,Qt)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol(Qt).toList(),r=st.H.calc(i,((t,e)=>Kt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{n.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=n.getCol("sequence_id");n.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),n.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){Xt(t)}}()}async function ms(){await async function(){let t,e,s,n,o;const a=Vt.AL.UMAP;try{const l=new zt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([Ce.files.readCsv(se),$t(),jt()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=300,n.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await Ve(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),n.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),ee()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=s.getCol("sequence").toList(),r=st.H.calc(i,((t,e)=>Kt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(n.grid,o,void 0,150,void 0),n.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){Xt(t)}}()}async function ds(){await async function(){const t="HELM";let e,s,o;try{await new zt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ce.files.readCsv("samples/HELM.csv"),s=i.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const i=s.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await Be(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const i=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),o=n.dialog().add(a).show(),await(0,Ft.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){Xt(t)}}()}async function ps(){await async function(){let t,e,s,n,o,a;const l="msa(HELM)",h=Vt.AL.UMAP;try{const c=new zt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await Ce.files.readCsv(ne)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=ie.J[0];n=await(0,ie.f)(s,l,t,1.53,0,void 0),e.columns.add(n),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await De(e,n,h,W.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Xt(t)}}()}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class n{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",i="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const n=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[n][e].parentJ}return new n(s,i,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let i=1;i<=this.len1;i++)for(let n=1;n<=this.len2;n++)this.fillOne(i,n),this.dpGrid[i][n].value<=0?(this.dpGrid[i][n].value=0,this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0):0==this.dpGrid[this.dpGrid[i][n].parentI][this.dpGrid[i][n].parentJ].value&&(this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0),this.dpGrid[i][n].value>t&&(t=this.dpGrid[i][n].value,e=i,s=n);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class g{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,i){this.pos=t,this.name=e,this._freqs=s??{},i?.rowCount&&(this.rowCount=i.rowCount),i?.sumForHeightCalc&&(this.sumForHeightCalc=i.sumForHeightCalc),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new g),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,i])=>i.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,i,n,o,a,l){const h=window.devicePixelRatio,c=s==u.ES.Entropy?e*(i-this.sumForHeightCalc)/i:e;let m=l*a+(e-c-1);const d=Object.entries(this._freqs).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const e of d){const s=e[1],i=c*s.count/this.rowCount;s.bounds=new r.Rect(t*h*n,m,o*h,i),m+=i}}render(t,e,s,i,n,r,o){for(const[a,l]of Object.entries(this._freqs))if("-"!==a){const h=(0,c.GU)(a,5),u=l.bounds,m=u.left-n*r;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(m,u.top,u.width,u.height),t.fillStyle=o.get(a)??o.get("other"),t.textAlign="left",t.font=e;const d=t.measureText(h);t.setTransform(u.width/d.width,0,0,u.height/i,m,u.top),t.fillText(h,0,-s)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const w=u.vS;var b;!function(t){t[t.None=0]="None",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(b||(b={}));class v extends r.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler?.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.positions=[],this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewSubs=[],this._onSizeChanged=new l.Subject,this.renderRequested=!1,this.recalcLevelRequested=b.Freqs,this.viewerId=v.viewerCount,v.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(p.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(p.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(p.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(p.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,w.fixWidth,{category:d.LAYOUT}),this.fitArea=this.bool(p.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(p.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(p.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=n.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=n.canvas(),this.canvas.style.width="100%"}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}buildView(){const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=n.div("No message"),this.msgHost.style.display="none",this.canvas=n.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=n.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.root.append(this.host),this.root.append(this.slider.root),this.updateSlider(),this.render(b.Freqs,"init"),this.error&&(this.msgHost.innerText=this.error.message,n.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.updateSlider(),this.render(b.Layout,"rootOnSizeChanged")}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(u.DX.positionNames),i=this.seqCol.getTag(u.DX.positionLabels);this.positionNames=s?s.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=i?i.split(u.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),s=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,s=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,s)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:this.updateSeqCol();break;case p.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case p.fixWidth:case p.fitArea:case p.positionMargin:this.updateSlider();break;case p.shrinkEmptyTail:case p.skipEmptyPositions:this.updatePositions()}switch(t.name){case p.fixWidth:case p.fitArea:case p.positionWidth:case p.positionMargin:this.render(b.Layout,"onPropertyChanged");break;default:this.render(b.Freqs,"onPropertyChanged")}}onTableAttached(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}get onSizeChanged(){return this._onSizeChanged}getMonomer(t,e){const s=t.x+this.firstVisibleIndex*this.positionWidthWithMargin*e,i=Math.floor(t.x/(this.positionWidthWithMargin*e)+this.firstVisibleIndex),n=this.positions[i];if(void 0===n)return[i,null,null];const r=n.getMonomerAt(s,t.y);return void 0===r?[i,null,null]:[i,r,n.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>!t.hasMonomer("-")||t.getFreq("-").count!==t.rowCount)).toArray())}render(t,e){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevel=${t}, reason='${e}' )`);const s=()=>{if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,i=this.dataFrame.rowCount,n=this.unitsHandler.splitted;for(let e=0;e<i;++e)if(s.get(e)){const s=n[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||"-";this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions()},n=t=>{f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const e=this.positions.length;this.calcSize();const s=this.canvas.height-this.axisHeight*t,n=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==n&&i.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(n);for(let i=0;i<e;i++)this.positions[i].calcScreen(i,s,this.positionHeight,r,this.positionWidthWithMargin,this._positionWidth,t,this.axisHeight)},o=t=>{if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio;t>=b.Freqs&&s(),t>=b.Layout&&n(window.devicePixelRatio);const o=this.Length;e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const a=this.countOfRenderPositions+1,l=this.visibleSlider?Math.floor(this.slider.min):0,h=Math.min(o,l+a),c=10*i;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${c.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const u=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),m=u<this._positionWidth*i-2?1:(this._positionWidth*i-2)/u;for(let t=this.firstVisibleIndex;t<h;t++){const s=this.positions[t];e.resetTransform(),e.setTransform(m,0,0,1,t*this.positionWidthWithMargin*i+this._positionWidth*i/2-this.positionWidthWithMargin*l,0),e.fillText(s.label,0,0)}for(let t=this.firstVisibleIndex;t<h;t++)this.positions[t].render(e,"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.positionWidthWithMargin,l,this.cp);f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};if(this.recalcLevelRequested=Math.max(this.recalcLevelRequested,t),!this.renderRequested)switch(this.renderRequested=!0,this.recalcLevelRequested){case b.Freqs:window.setTimeout((()=>{o(this.recalcLevelRequested),this.recalcLevelRequested=b.None,this.renderRequested=!1}),0);break;case b.Layout:case b.None:window.requestAnimationFrame((t=>{o(this.recalcLevelRequested),this.recalcLevelRequested=b.None,this.renderRequested=!1}))}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,s=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,s*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${s}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${s}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let n=0;switch(this.verticalAlignment){case"top":n=0;break;case"middle":n=Math.max(0,(this.root.clientHeight-s)/2);break;case"bottom":n=Math.max(0,this.root.clientHeight-s-t)}let r=0;switch(this.horizontalAlignment){case"left":r=0;break;case"center":r=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":r=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${n}px`,"important"),this.host.style.setProperty("margin-left",`${r}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${n+i}px`,"important"),this.root.clientHeight<=s?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}this._lastWidth!==this.root.clientWidth&&this._lastHeight!==this.root.clientHeight&&(this._lastWidth=this.root.clientWidth,this._lastHeight=this.root.clientHeight,this._onSizeChanged.next())}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(b.Layout,"sliderOnValuesChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){f._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()");try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(b.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){f._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()");try{this.filterSource===u.Ct.Selected&&this.render(b.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,i=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(i,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,i,n){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=n.pos;(s<t.length?t[s]:null)===i&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),i=n.div([n.div(`${o}`),n.div(`${e} rows`)]);n.tooltip.show(i,s.x+16,s.y+16)}else n.tooltip.hide()}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[i,n]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&n){const t=this.positions[i],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,i,n,r){const 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this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(n.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(n.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new g:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new w,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class f{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class g extends f{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends g{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set 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1
+ var bio;(()=>{var t={6e3:(t,e,s)=>{"use strict";var i;s(4469),s(976),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(i||(i={}))},7997:(t,e,s)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function n(t){let e=0;for(let s=0;s<t.length;s++)e+=t[s]*t[s];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let s=0;for(let i=0;i<t.length;i++)s+=t[i]*e[i];return s}s.d(e,{$G:()=>n,MA:()=>r,hu:()=>i})},2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>n});var i=s(9976);class n extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,n)),this.lesk}static get GrokGroups(){return void 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isNaN(parseInt(s))?[i,s]:[i,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[i,n]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,n=n.length>6?`${n.slice(0,3)}...`:n,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,n,1]:[this.undefinedColor,i,n,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,n,2]:[this.undefinedColor,i,n,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,n,3]:[this.undefinedColor,i,n,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,n,4]:[this.undefinedColor,i,n,4]}return[this.undefinedColor,i,n,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>o,Xk:()=>r});var i=s(976),n=(s(4469),s(1047));function r(t){const e=[];for(let s=0;s<t.rowCount;s++){const i={};Object.keys(n.K4).forEach((e=>{if("symbol"===e){const r=t.get(n.K4[e],s);i[e]="."===r?t.get(n.At,s):r}else if("rgroups"===e){const r=t.get(n.K4[e],s).split("\n"),o=[];r.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===s?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else n.K4[e]&&(i[e]=t.get(n.K4[e],s))})),e.push(i)}return e}async function o(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}s(6066)},6375:(t,e,s)=>{"use strict";s.d(e,{i0:()=>d});var i=s(4469),n=s(976),r=s(1821),o=s(7767),a=s(499);const l={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M 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this._updated}constructor(t,e,s){this.grid=t,this.col=e,this.propsProvider=s,this._monomerLengthList=null,this.separatorWidth=5,this._updated=!1,this._monomerLengthMap={},this._monomerStructureMap={},this.subs=[],this._splitter=(0,r.Mj)(this.col),this.props=this.propsProvider(),this._rowsProcessed=n.BitSet.create(this.col.length),this.grid&&(this.subs.push(e.dataFrame.onDataChanged.subscribe((()=>{this.props=this.propsProvider(),this._monomerLengthList=null,this._rowsProcessed=n.BitSet.create(this.col.length)}))),this.subs.push(i.events.onViewRemoved.subscribe((t=>{this.grid?.view?.id===t.id&&this.destroy()}))))}destroy(){for(const t of this.subs)t.unsubscribe()}getCellMonomerLengths(t){const e=this.props.unitsHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t),s=new Array(e.length+1);s[0]=5;for(let t=1;t<s.length;t++)s[t]=s[t-1]+e[t-1];return[e,s]}getCellMonomerLengthsForSeq(t){null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.col.length).fill(null),this._updated=!0);let e=this._monomerLengthList[t];if(null===e){const s=this.getSeqMonList(t);e=this._monomerLengthList[t]=new Array(s.length);for(const[t,i]of s.entries()){const s=this.props.monomerToShort(i,this.props.monomerLengthLimit),n=(this.props.unitsHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.monomerCharWidth;e[t]=n}this._updated=!0}return e}getCellMonomerLengthsForSeqMsa(){var t;null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null),this._updated=!0),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],s=Math.max(Math.floor((this.grid?.vertScroll.min??0)-10),0),i=Math.min(Math.ceil((this.grid?.vertScroll.max??0)+10),this.col.length);for(let t=s;t<i;t++){if(this._rowsProcessed.get(t))continue;const s=this.getSeqMonList(t);s.length>e.length&&e.push(...new Array(s.length-e.length).fill(0));for(const[t,i]of s.entries()){const s=this.props.monomerToShort(i,this.props.monomerLengthLimit),n=this.props.separatorWidth+s.length*this.props.monomerCharWidth;e[t]=Math.max(e[t]??0,n)}this._updated=!0}return e}getPosition(t,e){const[s,i]=this.getCellMonomerLengths(t),n=this.col.get(t);let r=100,o=null,a=this._splitter(n).length,l=!1,h=0;if(i[0]<=e&&e<i.slice(-1)[0])for(;!l;)if(h=Math.floor((a+(o??0))/2),e>=i[h]&&e<=i[h+1]?(o=h,l=!0):e<i[h]?a=h-1:e>i[h+1]&&(o=h+1),o==a&&(l=!0),--r<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(i)}. `);return o}getSeqMonList(t){const e=this.col.get(t);return e?this._splitter(e):[]}getMonomer(t){const e=this.props.unitsHandler.alphabet??"UN",s=o[e];return this.props.monomerLib?.getMonomer(s,t)??null}setMonomerLengthLimit(t){this.props.monomerLengthLimit=t,this._updated=!0}setSeparatorWidth(t){this.props.separatorWidth=t,this._updated=!0}isMsa(){return this.props.unitsHandler.isMsa()}}},1047:(t,e,s)=>{"use strict";s.d(e,{At:()=>n,K4:()=>r,rx:()=>i});const i=["symbol","molfile","rgroups","name"],n="MonomerName",r={monomerType:null,smiles:null,name:"MonomerName",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerCode"}},5226:(t,e,s)=>{"use strict";s.d(e,{i:()=>o});var i=s(976),n=s(499),r=s(1821);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,s=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==s&&this._sequencesArray.push(this.parseMacromolecule(s,e.index)),s=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(s,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.setTag(i.TAGS.UNITS,r.r2.FASTA),n.Cn.getOrCreate(e),[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},1821:(t,e,s)=>{"use strict";s.d(e,{BM:()=>r,XS:()=>a,r2:()=>i});var i,n=s(6286);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm"}(i||(i={}));const r=/(\[[A-Za-z0-9-_]+\]|.)/g,o=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},a=[new n.L("PT",o.fasta.peptide,.5),new n.L("DNA",o.fasta.dna,.55),new n.L("RNA",o.fasta.rna,.55)]},8447:(t,e,s)=>{"use strict";s.d(e,{GU:()=>n.GU,Mj:()=>n.Mj,dQ:()=>n.dQ,kB:()=>n.kB,py:()=>n.py,r2:()=>i.r2,up:()=>n.up,vU:()=>n.vU});var i=s(1821),n=s(6066)},6286:(t,e,s)=>{"use strict";s.d(e,{L:()=>i,d:()=>n});class i{constructor(t,e,s){this.name=t,this.alphabet=e,this.cutoff=s}}class n extends i{constructor(t,e,s){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=s}}},6066:(t,e,s)=>{"use strict";s.d(e,{w4:()=>M,py:()=>A,vU:()=>b,Mj:()=>v,Ar:()=>f,GU:()=>S,dQ:()=>T,up:()=>E,kB:()=>p});var i=s(976),n=s(6414),r=s.n(n),o=s(6286),a=s(1821),l=s(499);class h extends Float32Array{}var c=s(7997),u=s(2012),m=s(6137),d=s(7331);function p(t){return t.toString().replace(a.BM,".$1").slice(1).split(".").map((t=>t.startsWith("[")&&t.endsWith("]")?t.slice(1,-1):"-"===t?"":t))}function f(t,e=undefined){return s=>s.split(t,e)}const g=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,y=/\[([^\[\]]+)]/g;function w(t){g.lastIndex=0;const e=g.exec(t.toString()),s=e?e[2]:null;return(s?s.split("."):[]).map((t=>{y.lastIndex=0;const e=y.exec(t);return e&&e.length>=2?e[1]:t}))}function b(t,e,s=undefined){if(t.toLowerCase().startsWith(a.r2.FASTA))return p;if(t.toLowerCase().startsWith(a.r2.SEPARATOR))return f(e,s);if(t.toLowerCase().startsWith(a.r2.HELM))return w;throw new Error(`Unexpected units ${t} .`)}function v(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`Get splitter for semType "${i.SEMTYPE.MACROMOLECULE}" only.`);return b(t.getTag(i.TAGS.UNITS),t.getTag("separator"))}const C=/([^\W_]+)/g;function S(t,e){if(t.length<=e)return t;const s=t.match(C),i=t.length>e||(s?.length??0)>1,n=s?.[0]??" ";return i?n.substring(0,e-1)+"…":n}function M(t,e,s="-"){const i=e.map((e=>{const i=function(t,e,s="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(s);const n=[],r=[];for(const s of i)n.push(s in t?t[s]:0),r.push(e.has(s)?1:0);const o=new h(n),a=new h(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,s);return new o.d(e,t,i)}));let n;const r=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return n=r>0?i.find((t=>t.similarity===r)).name:"UN",n}function T(t,e=5){let s;if(t.semType==i.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const i=function(t,e,s){return t.categories,function(t,e){const s={};let i=!0,n=null;for(const r of t)if(null==n?n=r.length:r.length!==n&&(i=!1),r.length>=e)for(const t of r)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:i}}(r()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,p);s=M(i.freq,a.XS)}return A(s)}function A(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function E(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},7767:(t,e,s)=>{"use strict";s.d(e,{L:()=>l});var i=s(6414),n=s.n(i),r=s(499),o=s(1821),a=s(6066);class l extends r.Cn{get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,i){i||(i=this.toFasta(e)?r._9[o.r2.FASTA]:r._9[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const n=/(R\(|D\(|\)|P)/g,a=t.startsWith("DNA")||t.startsWith("RNA"),l=this.splitter(t),h=[];for(let t=0;t<l.length;t++){let s=l[t];if(a&&(s=s.replace(n,"")),s===r._9[o.r2.HELM])h.push(i);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";h.push(t)}else h.push(s)}return h.join(s)}convert(t,e){const s=this.getConverter(t,e),i=this.getNewColumn(t,e);return i.init((t=>s(this.column.get(t)))),i}constructor(t){super(t),this._splitter=null}getConverter(t,e=null){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?c(t,e):t.getSplitter()(e),i=new Array(s.length);for(const[e,a]of n().enumerate(s)){let n=e;t.isHelm()&&(n=e.replace(h,"$1")),t.isGap(n)?n=r._9[o.r2.FASTA]:n.length>1&&(n="["+s[a]+"]"),i[a]=n}return i.join("")}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA"),i=e.startsWith("RNA"),[n,a,l,c]=t.getHelmWrappers();return`${n}${t.getSplitter()(e).map((e=>{let n=e;return n=t.isGap(n)?r._9[o.r2.HELM]:s||i?n.replace(h,"$1"):1==e.length?`${a}${e}${l}`:`${a}[${e}]${l}`,n})).join(".")}${c}`}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const i=t.isHelm()?c(t,e):t.getSplitter()(e),a=new Array(i.length);e.startsWith("PEPTIDE");for(const[e,s]of n().enumerate(i)){let i=e;t.isGap(i)&&(i=r._9[o.r2.SEPARATOR]),a[s]=i}return a.filter((t=>null!==t)).join(s)}(s,t,e)};throw new Error}}const h=/[RD]\((\w)\)P?/g;function c(t,e){const s=t.getSplitter()(e),i=new Array(s.length),r=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of n().enumerate(s)){let s=t;(r||o)&&(s=s.replace(h,"$1"),s="P"===s?null:s),i[e]=s}return i.filter((t=>null!==t))}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>c,_9:()=>h});var i=s(976),n=s(1821),r=s(6066),o=s(489),a=s(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}},h={[n.r2.FASTA]:"-",[n.r2.SEPARATOR]:"",[n.r2.HELM]:"*"};class c{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.FASTA)throw new Error(`The column of notation '${n.r2.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,n.r2.FASTA),c.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==n.r2.SEPARATOR)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${n.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(i.TAGS.UNITS,n.r2.SEPARATOR),t.column.setTag("separator",e),c.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${n.r2.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,n.r2.HELM),c.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[n.r2.FASTA,n.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");const e=s.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const i=(0,r.w4)(s.freq,n.XS);if(t.column.setTag("alphabet",i),"UN"===i){const e=Object.keys(s.freq).length,i=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===n.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==n.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===n.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),i=this._column.categories;for(let n=0;n<e;n++){const e=i[s[n]];this._splitted[n]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const i of this.splitted){null==s?s=i.length:i.length!==s&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return this.notation===n.r2.FASTA}isSeparator(){return this.notation===n.r2.SEPARATOR}isHelm(){return this.notation===n.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===n.r2.FASTA&&t===h.FASTA||this.units===n.r2.HELM&&t===h.HELM}getNotation(){if(this.units.toLowerCase().startsWith(n.r2.FASTA))return n.r2.FASTA;if(this.units.toLowerCase().startsWith(n.r2.SEPARATOR))return n.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(n.r2.HELM))return n.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,r=s.length,o=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(o),l=i.Column.fromList("string",a,new Array(r).fill(""));if(l.semType=i.SEMTYPE.MACROMOLECULE,l.setTag(i.TAGS.UNITS,t),t===n.r2.SEPARATOR){if(!e)throw new Error(`Notation '${n.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==n.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=c.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[n.r2.FASTA,n.r2.SEPARATOR,n.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!c.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const n=i.Column.fromList("string",e,new Array(t).fill(""));return n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,s),n}getSplitter(){return(0,r.Mj)(this._column)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,r.Ar)(this.separator);for(const t of this.column.categories){const i=s(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}constructor(t){if(this._splitted=null,this._stats=null,t.type!=i.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${i.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h[n.r2.FASTA]:this.isHelm()?h[n.r2.HELM]:h[n.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())c.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");c.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);c.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new c(t)),t.temp[l.uhTemp]}}},9298:(t,e,s)=>{"use strict";var i,n,r,o,a,l;s.d(e,{CI:()=>c,Ct:()=>l,DX:()=>i,ES:()=>n,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.positionNames=".wl.positionNames",t.positionLabels=".wl.positionLabels",t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=n.full,this.positionWidth=16,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}},c=", "},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>i});class i{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(18),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0){return new Promise((async(i,n)=>{try{const n=t.length,r=new Array(this._workerCount),o=n*(n-1)/2;this._workerCount=Math.min(this._workerCount,o);const a=o/this._workerCount,l=new 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this}subRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){w(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){b(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){A(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)>t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){A(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)<t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}maxRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){w(this,t),A(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),s[1]=i);return s}minRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){w(this,t),A(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),s[1]=i);return s}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){b(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),s[0]=i);return s}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){b(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),s[0]=i);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let i=0;i<e.length;i++)s+=e[i]*t[i];return s}mmul(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.columns,n=new N(e,i),r=new Float64Array(s);for(let o=0;o<i;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let i=0;i<s;i++)e+=this.get(t,i)*r[i];n.set(t,o,e)}}return n}strassen2x2(t){t=N.checkMatrix(t);let e=new N(2,2);const s=this.get(0,0),i=t.get(0,0),n=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(i+h),u=(o+l)*i,m=s*(r-h),d=l*(a-i),p=(s+n)*h,f=c+d-p+(n-l)*(a+h),g=m+p,y=u+d,w=c-u+m+(o-s)*(i+r);return e.set(0,0,f),e.set(0,1,g),e.set(1,0,y),e.set(1,1,w),e}strassen3x3(t){t=N.checkMatrix(t);let e=new N(3,3);const s=this.get(0,0),i=this.get(0,1),n=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),p=t.get(1,0),f=t.get(1,1),g=t.get(1,2),y=t.get(2,0),w=t.get(2,1),b=t.get(2,2),v=(s-r)*(-m+f),C=(-s+r+o)*(u-m+f),S=(r+o)*(-u+m),M=s*u,T=(-s+l+h)*(u-d+g),A=(-s+l)*(d-g),E=(l+h)*(-u+d),x=(-n+h+c)*(f+y-w),L=(n-c)*(f-w),I=n*y,_=(h+c)*(-y+w),R=(-n+o+a)*(g+y-b),k=(n-a)*(g-b),O=(o+a)*(-y+b),P=M+I+i*p,G=(s+i+n-r-o-h-c)*f+C+S+M+x+I+_,F=M+T+E+(s+i+n-o-a-l-h)*g+I+R+O,W=v+o*(-u+m+p-f-g-y+b)+C+M+I+R+k,V=v+C+S+M+a*w,H=I+R+k+O+r*d,D=M+T+A+h*(-u+d+p-f-g-y+w)+x+L+I,B=x+L+I+_+l*m,Z=M+T+A+E+c*b;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,D),e.set(2,1,B),e.set(2,2,Z),e}mmulStrassen(t){t=N.checkMatrix(t);let e=this.clone(),s=e.rows,i=e.columns,n=t.rows,r=t.columns;function o(t,e,s){let i=t.rows,n=t.columns;if(i===e&&n===s)return t;{let i=E.zeros(e,s);return i=i.setSubMatrix(t,0,0),i}}i!==n&&console.warn(`Multiplying ${s} x ${i} and ${n} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,n),l=Math.max(i,r);return e=o(e,a,l),function t(e,s,i,n){if(i<=512||n<=512)return e.mmul(s);i%2==1&&n%2==1?(e=o(e,i+1,n+1),s=o(s,i+1,n+1)):i%2==1?(e=o(e,i+1,n),s=o(s,i+1,n)):n%2==1&&(e=o(e,i,n+1),s=o(s,i,n+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),f=s.subMatrix(r,s.rows-1,a,s.columns-1),g=t(E.add(l,p),E.add(h,f),r,a),y=t(E.add(m,p),h,r,a),w=t(l,E.sub(u,f),r,a),b=t(p,E.sub(d,h),r,a),v=t(E.add(l,c),f,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(d,f),r,a),M=E.add(g,b);M.sub(v),M.add(S);let T=E.add(w,v),A=E.add(y,b),x=E.sub(g,y);x.add(w),x.add(C);let N=E.zeros(2*M.rows,2*M.columns);return N=N.setSubMatrix(M,0,0),N=N.setSubMatrix(T,M.rows,0),N=N.setSubMatrix(A,0,M.columns),N=N.setSubMatrix(x,M.rows,M.columns),N.subMatrix(0,i-1,0,n-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.rows;t++){const n=this.getRow(t);n.length>0&&m(n,{min:e,max:s,output:n}),i.setRow(t,n)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let i=new N(this.rows,this.columns);for(let t=0;t<this.columns;t++){const n=this.getColumn(t);n.length&&m(n,{min:e,max:s,output:n}),i.setColumn(t,n)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),i=this.get(e,this.columns-1-s);this.set(e,s,i),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),i=this.get(this.rows-1-s,e);this.set(s,e,i),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=N.checkMatrix(t);let e=this.rows,s=this.columns,i=t.rows,n=t.columns,r=new N(e*i,s*n);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<i;s++)for(let a=0;a<n;a++)r.set(i*o+s,n*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=N.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,i=this.kroneckerProduct(N.eye(s,s)),n=N.eye(e,e).kroneckerProduct(t);return i.add(n)}transpose(){let t=new N(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,i){S(this,t,e,s,i);let n=new N(e-t+1,i-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=i;e++)n.set(r-t,e-s,this.get(r,e));return n}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let i=new N(t.length,s-e+1);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.rows)throw new RangeError(`Row index out of range: ${t[n]}`);i.set(n,r-e,this.get(t[n],r))}return i}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let i=new N(s-e+1,t.length);for(let n=0;n<t.length;n++)for(let r=e;r<=s;r++){if(t[n]<0||t[n]>=this.columns)throw new RangeError(`Column index out of range: ${t[n]}`);i.set(r-e,n,this.get(r,t[n]))}return i}setSubMatrix(t,e,s){if((t=N.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let i=0;i<t.rows;i++)for(let n=0;n<t.columns;n++)this.set(e+i,s+n,t.get(i,n));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new N(t.length,e.length);for(let i=0;i<t.length;i++){let n=t[i];for(let t=0;t<e.length;t++){let r=e[t];s.set(i,t,this.get(n,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new N(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]+=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]+=t.get(s,i);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e+=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[s]*=t.get(s,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let i=0;i<t.columns;++i)e[i]*=t.get(s,i);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)e*=t.get(s,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(o,e)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,s){const i=t.rows,n=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,o)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,s){const i=t.rows,n=t.columns,r=i*n;let o=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<n;i++)l=t.get(e,i)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e[i])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e[i])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let i=0;i<t.columns;i++)for(let n=0;n<t.rows;n++)s+=Math.pow(t.get(n,i),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let i=0;i<t.columns;i++)t.set(s,i,t.get(s,i)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return f(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return f(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class N extends E{constructor(t,e){if(super(),N.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(s[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[i]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return w(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),w(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let i=0;i<t;i++)s[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)s[i-1]=this.data[e][i];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let s=0;s<this.rows;s++){const i=new Float64Array(this.columns+1);let n=0;for(;n<t;n++)i[n]=this.data[s][n];for(i[n++]=e[s];n<this.columns+1;n++)i[n]=this.data[s][n-1];this.data[s]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,N);class L extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class I{constructor(t){let e,s,i,n,r,o,a,l,h,c=(t=L.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),p=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,i=0;i<h;i++)r+=c.get(e,i)*l[i];l[e]-=r,c.set(e,s,l[e])}for(n=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[n])&&(n=e);if(n!==s){for(i=0;i<m;i++)o=c.get(n,i),c.set(n,i,c.get(s,i)),c.set(s,i,o);a=d[n],d[n]=d[s],d[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=N.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,i,n,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(n=0;n<a;n++)for(s=n+1;s<a;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n));for(n=a-1;n>=0;n--){for(i=0;i<r;i++)o.set(n,i,o.get(n,i)/e.get(n,n));for(s=0;s<n;s++)for(i=0;i<r;i++)o.set(s,i,o.get(s,i)-o.get(n,i)*e.get(s,n))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let i=0;i<s;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n>e?i.set(n,e,t.get(n,e)):n===e?i.set(n,e,1):i.set(n,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,i=new N(e,s);for(let n=0;n<e;n++)for(let e=0;e<s;e++)n<=e?i.set(n,e,t.get(n,e)):i.set(n,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,i,n,r=(t=L.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<o;e++)t=_(t,r.get(e,i));if(0!==t){for(r.get(i,i)<0&&(t=-t),e=i;e<o;e++)r.set(e,i,r.get(e,i)/t);for(r.set(i,i,r.get(i,i)+1),s=i+1;s<a;s++){for(n=0,e=i;e<o;e++)n+=r.get(e,i)*r.get(e,s);for(n=-n/r.get(i,i),e=i;e<o;e++)r.set(e,s,r.get(e,s)+n*r.get(e,i))}}l[i]=-t}this.QR=r,this.Rdiag=l}solve(t){t=N.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,n,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(n=0;n<a;n++){for(o=0,i=r;i<s;i++)o+=e.get(i,r)*l.get(i,n);for(o=-o/e.get(r,r),i=r;i<s;i++)l.set(i,n,l.get(i,n)+o*e.get(i,r))}for(r=h-1;r>=0;r--){for(n=0;n<a;n++)l.set(r,n,l.get(r,n)/this.Rdiag[r]);for(i=0;i<r;i++)for(n=0;n<a;n++)l.set(i,n,l.get(i,n)-l.get(r,n)*e.get(i,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,i=s.columns,n=new N(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?n.set(t,e,s.get(t,e)):t===e?n.set(t,e,this.Rdiag[t]):n.set(t,e,0);return n}get orthogonalMatrix(){let t,e,s,i,n=this.QR,r=n.rows,o=n.columns,a=new N(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==n.get(s,s)){for(i=0,t=s;t<r;t++)i+=n.get(t,s)*a.get(t,e);for(i=-i/n.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+i*n.get(t,s))}}return a}}class k{constructor(t,e={}){if((t=L.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,i=t.columns;const{computeLeftSingularVectors:n=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(n),h=Boolean(r),c=!1;if(s<i)if(o){a=t.transpose(),s=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,i),m=Math.min(s+1,i),d=new Float64Array(m),p=new N(s,u),f=new N(i,i),g=new Float64Array(i),y=new Float64Array(s),w=new Float64Array(m);for(let t=0;t<m;t++)w[t]=t;let b=Math.min(s-1,i),v=Math.max(0,Math.min(i-2,s)),C=Math.max(b,v);for(let t=0;t<C;t++){if(t<b){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<i;e++){if(t<b&&0!==d[t]){let i=0;for(let n=t;n<s;n++)i+=a.get(n,t)*a.get(n,e);i=-i/a.get(t,t);for(let n=t;n<s;n++)a.set(n,e,a.get(n,e)+i*a.get(n,t))}g[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<v){g[t]=0;for(let e=t+1;e<i;e++)g[t]=_(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<s&&0!==g[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<i;s++)y[e]+=g[s]*a.get(e,s);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let n=t+1;n<s;n++)a.set(n,e,a.get(n,e)+i*y[n])}}if(h)for(let e=t+1;e<i;e++)f.set(e,t,g[e])}}let S=Math.min(i,s+1);if(b<i&&(d[b]=a.get(b,b)),s<S&&(d[S-1]=0),v+1<S&&(g[v]=a.get(v,S-1)),g[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let i=0;for(let n=t;n<s;n++)i+=p.get(n,t)*p.get(n,e);i=-i/p.get(t,t);for(let n=t;n<s;n++)p.set(n,e,p.get(n,e)+i*p.get(n,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<v&&0!==g[t])for(let e=t+1;e<i;e++){let s=0;for(let n=t+1;n<i;n++)s+=f.get(n,t)*f.get(n,e);s=-s/f.get(t+1,t);for(let n=t+1;n<i;n++)f.set(n,e,f.get(n,e)+s*f.get(n,t))}for(let e=0;e<i;e++)f.set(e,t,0);f.set(t,t,1)}let M=S-1,T=0,A=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+A*Math.abs(d[t]+Math.abs(d[t+1]));if(Math.abs(g[t])<=e||Number.isNaN(g[t])){g[t]=0;break}}if(t===S-2)e=4;else{let s;for(s=S-1;s>=t&&s!==t;s--){let e=(s!==S?Math.abs(g[s]):0)+(s!==t+1?Math.abs(g[s-1]):0);if(Math.abs(d[s])<=A*e){d[s]=0;break}}s===t?e=3:s===S-1?e=1:(e=2,t=s)}switch(t++,e){case 1:{let e=g[S-2];g[S-2]=0;for(let s=S-2;s>=t;s--){let n=_(d[s],e),r=d[s]/n,o=e/n;if(d[s]=n,s!==t&&(e=-o*g[s-1],g[s-1]=r*g[s-1]),h)for(let t=0;t<i;t++)n=r*f.get(t,s)+o*f.get(t,S-1),f.set(t,S-1,-o*f.get(t,s)+r*f.get(t,S-1)),f.set(t,s,n)}break}case 2:{let e=g[t-1];g[t-1]=0;for(let i=t;i<S;i++){let n=_(d[i],e),r=d[i]/n,o=e/n;if(d[i]=n,e=-o*g[i],g[i]=r*g[i],l)for(let e=0;e<s;e++)n=r*p.get(e,i)+o*p.get(e,t-1),p.set(e,t-1,-o*p.get(e,i)+r*p.get(e,t-1)),p.set(e,i,n)}break}case 3:{const e=Math.max(Math.abs(d[S-1]),Math.abs(d[S-2]),Math.abs(g[S-2]),Math.abs(d[t]),Math.abs(g[t])),n=d[S-1]/e,r=d[S-2]/e,o=g[S-2]/e,a=d[t]/e,c=g[t]/e,u=((r+n)*(r-n)+o*o)/2,m=n*o*(n*o);let y=0;0===u&&0===m||(y=u<0?0-Math.sqrt(u*u+m):Math.sqrt(u*u+m),y=m/(u+y));let w=(a+n)*(a-n)+y,b=a*c;for(let e=t;e<S-1;e++){let n=_(w,b);0===n&&(n=Number.MIN_VALUE);let r=w/n,o=b/n;if(e!==t&&(g[e-1]=n),w=r*d[e]+o*g[e],g[e]=r*g[e]-o*d[e],b=o*d[e+1],d[e+1]=r*d[e+1],h)for(let t=0;t<i;t++)n=r*f.get(t,e)+o*f.get(t,e+1),f.set(t,e+1,-o*f.get(t,e)+r*f.get(t,e+1)),f.set(t,e,n);if(n=_(w,b),0===n&&(n=Number.MIN_VALUE),r=w/n,o=b/n,d[e]=n,w=r*g[e]+o*d[e+1],d[e+1]=-o*g[e]+r*d[e+1],b=o*g[e+1],g[e+1]=r*g[e+1],l&&e<s-1)for(let t=0;t<s;t++)n=r*p.get(t,e)+o*p.get(t,e+1),p.set(t,e+1,-o*p.get(t,e)+r*p.get(t,e+1)),p.set(t,e,n)}g[S-2]=w,T+=1;break}case 4:if(d[t]<=0&&(d[t]=d[t]<0?-d[t]:0,h))for(let e=0;e<=M;e++)f.set(e,t,-f.get(e,t));for(;t<M&&!(d[t]>=d[t+1]);){let e=d[t];if(d[t]=d[t+1],d[t+1]=e,h&&t<i-1)for(let s=0;s<i;s++)e=f.get(s,t+1),f.set(s,t+1,f.get(s,t)),f.set(s,t,e);if(l&&t<s-1)for(let i=0;i<s;i++)e=p.get(i,t+1),p.set(i,t+1,p.get(i,t)),p.set(i,t,e);t++}T=0,S--}}if(c){let t=f;f=p,p=t}this.m=s,this.n=i,this.s=d,this.U=p,this.V=f}solve(t){let e=t,s=this.threshold,i=this.s.length,n=N.zeros(i,i);for(let t=0;t<i;t++)Math.abs(this.s[t])<=s?n.set(t,t,0):n.set(t,t,1/this.s[t]);let r=this.U,o=this.rightSingularVectors,a=o.mmul(n),l=o.rows,h=r.rows,c=N.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let s=0;for(let n=0;n<i;n++)s+=a.get(t,n)*r.get(e,n);c.set(t,e,s)}return c.mmul(e)}solveForDiagonal(t){return this.solve(N.diag(t))}inverse(){let t=this.V,e=this.threshold,s=t.rows,i=t.columns,n=new N(s,this.s.length);for(let r=0;r<s;r++)for(let s=0;s<i;s++)Math.abs(this.s[s])>e&&n.set(r,s,t.get(r,s)/this.s[s]);let r=this.U,o=r.rows,a=r.columns,l=new N(s,o);for(let t=0;t<s;t++)for(let e=0;e<o;e++){let s=0;for(let i=0;i<a;i++)s+=n.get(t,i)*r.get(e,i);l.set(t,e,s)}return l}get condition(){return 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i=s(4469),n=s(3870),r=s(976),o=s(6066);const a="rgb(100,100,100)",l="#808080",h="rgb(0,0,0)",c=o.GU;var u;function m(t,e,s,i,n,r,o=a,m=0,d=!1,p=1,f="",g=!1,y=u.classic,w=[],b=0,v=null,C=[],S=null,M={}){n.textAlign="start";let T=r.substring(0),A=g?"":f;y===u.MSA&&(A="");let E=!0,x=!0,N="difference";null!=v&&null!=v.cell.column&&(E=v.cell.column.temp["color-code"]??!0,x=v.cell.column.temp["compare-with-current"]??!0,N=v.cell.column.temp["highlight-difference"]??"difference");const L=C[b];x&&C.length>0&&"difference"===N&&(p=T==L?.3:p),x&&C.length>0&&"equal"===N&&(p=T!=L?.3:p),null!=S&&(T=c(T,S));const I=T+A;M[I]??(M[I]=n.measureText(I));let _=M[I];M[T]??(M[T]=n.measureText(T));let R=M[T].width;M[A]??(M[A]=n.measureText(A));const k=M[A].width,O=i/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,i){const 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230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[n.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const n={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=i.chem.svgMol(e.smiles,void 0,void 0,n);r.push(o),s._monomerStructureMap[t]=o}}n.tooltip.show(n.divV(r),e.x+16,e.y+16)}else n.tooltip.hide()}render(t,e,s,i,n,o,a){let l=0,h=999;const c=o.grid,d=o.cell.column,p=d.temp,y=p["monomer-width"];"short"===(null!=y?y:"short")&&(h=p[".mm.cellRenderer.maxMonomerLength"]??Ce.properties.MaxMonomerLength);let M=d.temp["bio-seqCol"];M||(M=new f.A(c,d,(()=>{const 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r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.regionTypes=this.stringList("regionTypes",[R.CDR],{choices:Object.values(R).filter((t=>t!=R.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16,{editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position. 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VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ce.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){Ce.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&n.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Ce.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<s.length;t++)for(const n of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==n));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,n,e]})())}const r=await Promise.all(i);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s;this.mainLayout=n.table(this.chains,(t=>[...s.length>0?[n.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",n.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=n.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",n.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=n.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Ce.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Ce.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{const t=window.devicePixelRatio,e=(this.root.clientHeight-54)/this.chains.length,s=Math.min(e,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));let i=0;for(let t=0;t<this.logos.length;t++){for(const e of this.chains)this.logos[t][e].root.style.height=`${s}px`;i+=Math.max(...this.chains.map((e=>this.logos[t][e].Length)))}if(0===this.positionWidth&&this.logos.length>0&&i>0){const e=22,s=13,n=9,r=(this.root.clientWidth-e-(this.logos.length-1)*n-s)/i*t;for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const s=this.chains[e];this.logos[t][s].setOptions({positionWidth:r})}}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?I.Ct.Selected:I.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const i=this.chains[s];this.logos[e][i].setOptions({[_.bo.filterSource]:t})}}}var O=s(9017),P=s(7656),G=s(7983),F=s(7767),W=s(489);async function V(t){const e=new F.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=W.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(g.r2.FASTA);i=t.toList(),s=w.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<i.length;e++)i[e]=t.seqCol.isNone(e)?null:i[e];const n=await(0,P.I)(i,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,n.embedding[e])));return{distance:n.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,G.HV)(t.seqCol,!1),await i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function H(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var D=s(5697),B=s(3379),Z=s.n(B),U=s(7795),Y=s.n(U),z=s(569),X=s.n(z),q=s(3565),K=s.n(q),$=s(9216),j=s.n($),J=s(4589),Q=s.n(J),tt=s(9414),et={};et.styleTagTransform=Q(),et.setAttributes=K(),et.insert=X().bind(null,"head"),et.domAPI=Y(),et.insertStyleElement=j(),Z()(tt.Z,et),tt.Z&&tt.Z.locals&&tt.Z.locals;var st=s(3914),it=s(6254);let nt=0;const rt="cliffsDf",ot=new L.Subject,at="act_diff",lt="sali",ht="sim",ct="line_index",ut=["1_seq","2_seq"],mt="filterCliffs";function dt(t,e,s){const i=e.getBoundingClientRect(),n=t.clientX-i.left,r=t.clientY-i.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-n,t.a[1]-r)+Math.hypot(t.b[0]-n,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var pt=s(1040);async function ft(t,e,s,n,o){e.version!==e.temp["last-invalidated-version"]&&await(0,G.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(n).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:n,simArr:o})}function gt(t){const e=n.divH([]),s=n.divV([n.divText(t.seqCol.name),n.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,i)=>{const r=n.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(n.divV([n.divText(t.seqCol.get(s)),r]))})),e}function yt(t){const e=n.div();e.append(n.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),i=new Array(2);t.line.mols.forEach(((e,n)=>{s[n]=t.seqCol.get(e),i[n]=t.activityCol.get(e)}));const o={},a=t.seqCol.getTag(r.TAGS.UNITS),l=t.seqCol.getTag("separator"),h=(0,g.vU)(a,l),c=bt(h(s[0]),h(s[1]),a,o);return e.append(n.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(vt(o)),e.append(wt("Activity delta",Math.abs(i[0]-i[1]))),e.append(wt("Cliff",t.sali)),e}function wt(t,e){return n.divH([n.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),n.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function bt(t,e,s,i){const n=document.createElement("canvas"),r=n.getContext("2d");return n.height=30,E(r,0,0,0,30,t,e,s,!0,i),n}function vt(t){const e=n.div();if(Object.keys(t).length>0){const s=n.divV([]);s.append(n.divH([n.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),n.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(n.divH([n.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function Ct(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}s(7861);var St=s(4004),Mt=s(7228),Tt=s(6375),At=s(5226);s(9133);class Et extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",D.kg[0],{choices:D.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(n.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var xt=s(7241),Nt=s(4293),Lt=s(2669);async function It(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=w.Cn.getOrCreate(t).getDistanceFunctionName(),i=new Lt.m(!0,!1),n=await i.calc(e,s);return i.terminate(),n}function _t(t){return(e,s)=>{const i=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?i(e,s):i(s,e)}}class Rt extends Et{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new L.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=w.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const n=s.plot.grid();n.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));n.cell("score",o).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Nt.Y)(this.root,n.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xt.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await It(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=w.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*i.length/o),u=s===a.length-1?Math.floor((s+1)*i.length/o):i.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:n}})=>{t?o(t):(h=Math.min(h,i),c=Math.max(c,n),l.set(e,r),s())},t.postMessage({fnName:n,values:i,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=_t(e),n=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,s)]:1-t[s]})));n.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=n.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=n.div(),s={},o=this.molCol?.name,a=t.col(o).getTag(r.TAGS.UNITS),l=t.col(o).getTag("separator"),h=(0,g.vU)(a,l),c=h(this.moleculeColumn.get(this.targetMoleculeIdx)),u=h(t.get(o,t.currentRowIdx)),m=bt(c,u,a,s);e.append(n.div(m,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&e.append(n.divV([n.divText("Different sequence length:",{style:{fontWeight:"bold"}}),n.divText(`target: ${c.length} monomers`),n.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(vt(s));const d=n.accordion(),p=n.element("i");p.className="grok-icon svg-icon svg-view-layout",d.addTitle(n.span([p,n.label("Similarity search")])),d.addPane("Differences",(()=>e),!0),i.shell.o=d.root}}var kt=s(8518);class Ot extends Et{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new L.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=w.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const i=r.DataFrame.fromColumns([s]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Nt.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xt.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await It(this.moleculeColumn),e=this.moleculeColumn.length,s=_t(e);this.renderMolIds=(0,kt.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[s(e,i)]))}}var Pt=s(9943),Gt=s(4413),Ft=s(1061),Wt=s(1345),Vt=s(116);const Ht={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Dt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=n.inputs([]),this.methodsParams={[Vt.AL.UMAP]:new Vt.bD,[Vt.AL.T_SNE]:new Vt.aP},this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=n.columnInput(Ht[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=n.choiceInput("Method",Vt.AL.UMAP,[Vt.AL.UMAP,Vt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=n.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):n.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=n.inputs([]);let e=!1;this.similarityMetricInput=n.choiceInput("Similarity",pt.gk.Tanimoto,D.Rt)}createAlgorithmSettingsDiv(t,e){return n.empty(t),Object.keys(e).forEach((s=>{const i=e[s],r=n.floatInput(i.uiName,i.value,(()=>{i.value=r.value}));n.tooltip.bind(r.root,i.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=n.columnInput(Ht[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),n.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Bt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=n.boolInput("Plot Embeddings",!0),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Zt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=n.intInput("Similarity cutoff",80),n.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),n.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Ut,Yt=function(t,e,s,i){return new(s||(s=Promise))((function(n,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};class zt{constructor(t,e,s=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._stopStartBtn=n.button(n.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=n.button(n.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=n.button(n.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._closeBtn=n.button(n.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,zt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=n.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(n.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=n.iconFA("clock");this._isAutomatic||0===e&&(s=n.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const i=n.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=n.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=n.divH([s,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,n,""),(null===(e=null===(t=n.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Yt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,i,a),yield(0,Ft.gw)(a));const l=n.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=n.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return Yt(this,void 0,void 0,(function*(){const i=n.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,zt.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return Yt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Xt(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ce.logger.error(t.message,void 0,s)}zt.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Ut||(Ut={}));const qt="data/sample_FASTA_PT_activity.csv";var Kt=s(1811);async function $t(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function jt(){return await i.functions.call("Dendrogram:getDendrogramService",{})}const Jt="data/sample_FASTA_PT_activity.csv",Qt="sequence";var te=s(3336),ee=s.n(te);const se="data/sample_FASTA_PT_activity.csv";var ie=s(8341);const ne="samples/HELM.csv";var re=s(2568),oe=s(525);class ae{constructor(){this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Ce.name}.${this._funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:"sequence"});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class le{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=n.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=n.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=n.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var he=s(9900);class ce{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const ue=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},me={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class de{constructor(t){this.grid=t,this.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.grid.dart||!t.tableColumn||!t.isTableCell||"Monomer"!=t.tableColumn.semType)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new ce(Se().getBioLib()).getCappedRotatedMonomer(a,o),h=n.div(o),c=l?i.chem.svgMol(l,void 0,void 0,me):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return n.tooltip.show(n.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){const e=t.dataFrame.temp;return ue.tooltipHandlerTemp in e||(e[ue.tooltipHandlerTemp]=new de(t),t.temp=e),e[ue.tooltipHandlerTemp]}}class pe extends r.GridCellRenderer{get name(){return p.Of.MONOMER}get cellType(){return p.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,i,n,r,o){if(r.gridRow<0)return;de.getOrCreate(r.grid),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,g.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,g.GU)(l,6),e+i/2,s+n/2,i)}}class fe extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new L.Subject}}class ge extends r.Package{get properties(){return this._properties}set properties(t){this._properties=t}}class ye extends r.Widget{constructor(t){super(n.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=n.intInput("Max monomer length",Ce.properties.MaxMonomerLength,(t=>{Ce.properties.MaxMonomerLength=t})),e=n.boolInput("Tooltip WebLogo",Ce.properties.TooltipWebLogo,(t=>{Ce.properties.TooltipWebLogo=t})),s=n.choiceInput("Default Separator",Ce.properties.DefaultSeparator,[".","/","-"],(t=>{Ce.properties.DefaultSeparator=t}));this.root.appendChild(n.form([t,e,s]))}}var we=s(5362),be={};be.styleTagTransform=Q(),be.setAttributes=K(),be.insert=X().bind(null,"head"),be.domAPI=Y(),be.insertStyleElement=j(),Z()(we.Z,be),we.Z&&we.Z.locals&&we.Z.locals;class ve extends r.Widget{constructor(t){super(n.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=w.Cn.getOrCreate(this.seqCol),e=Ce.properties.TooltipWebLogo,s=this.seqCol.getTag(I.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Ce=new ge;function Se(){return Wt.NT.instance}let Me=null;class Te{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Ae(){let t;await Promise.all([(async()=>{await Wt.NT.instance.loadLibraries()})(),(async()=>{t=await i.functions.call("Chem:getRdKitModule")})(),(async()=>{const t=await Ce.getProperties(),e=new fe(t);Ce.properties=e})()]);const e=Wt.NT.instance.getBioLib(),s=[],n=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const i=r[e].replaceAll("#R","O "),o=t.get_mol(i),a=JSON.parse(o.get_descriptors()).CrippenClogP;n.push(a),o?.delete()}));const o=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=n[t]<o?"#4682B4":"#DC143C";Me=new Te(a)}function Ee(t){const e=new ve(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();i.shell.error(e)})),e}function xe(){return Wt.NT.instance.getBioLib()}async function Ne(t){return(0,Wt.cf)()}function Le(t){const e=new ye(t);return e.init().then(),e}function Ie(){return new T}function _e(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=n.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:d.short,[d.short,d.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const i=n.intInput("Max monomer length",t.temp[".mm.cellRenderer.maxMonomerLength"]??Ce.properties.MaxMonomerLength,(e=>{t.temp[".mm.cellRenderer.maxMonomerLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));i.setTooltip(`The max length of monomer name displayed without shortening in '${d.short}' monomer width mode.`);const o=n.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",b.true),t.dataFrame.fireValuesChanged()}));o.setTooltip("The size of margin between monomers (in pixels)");const a=n.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));a.setTooltip("Color code");const l=n.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const h=n.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip('When on, all sequences get rendered in the "diff" mode');const c=n.inputs([s,i,o,l,a,h]);return new r.Widget(c)}(t)}function Re(t){return function(t){const e=n.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let i=y.UE.Color;switch(s){case"DNA":case"RNA":i=(0,g.py)("DNA");break;case"PT":i=(0,g.py)("PT")}const o=new Map;let a=0;const l=w.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),h=l.length;l.filter((t=>t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),a=Math.max(a,e+1)})),a/=h;const c={},u=Array.from(o.entries());u.sort(((t,e)=>e[1]-t[1])),u.forEach((([t,e])=>{const s=e/h,r=i.get(t),o=n.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/a*50+"px";const l=n.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,c[t]=n.div([o,l],{classes:"macromolecule-cell-comp-analysis-value"})}));const m=n.tableFromMap(c);return Array.from(m.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(m),new r.Widget(e)}(t)}function ke(){return new T}function Oe(){return new A}function Pe(t,e,s,i,n){const r=new O.k(i,n,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function Ge(){return new _.OZ}function Fe(){return new k}function We(t){const e=new Zt(r.SEMTYPE.MACROMOLECULE);n.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function Ve(t,e,o,a,l,h){if(!(0,re.n)(e,"Activity Cliffs"))return;const c=H(t),u={units:e.getTag(r.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},m=new F.L(e);let d=pt.gk.Tanimoto,p=e;if(m.isFasta()||m.isSeparator()&&m.alphabet&&"UN"!==m.alphabet)if(m.isFasta())d=m.getDistanceFunctionName();else{p=m.convert(g.r2.FASTA);const t=w.Cn.getOrCreate(p);d=t.getDistanceFunctionName(),u.units=g.r2.FASTA}const f=async()=>await async function(t,e,o,a,l,h,c,u,m,d,p,f,g,y,w,b,v,C){nt++;const S=c/100,M=o??e;let T=!1,A=!1;const E={};let x,N;const L={seqCol:M,methodName:m,similarityMetric:u,embedAxesNames:a,options:v},{distance:I,coordinates:_}=await f(L);for(const e of _)t.columns.add(e);let R=I;const k=Object.values(W.U).map((t=>t.toString())).includes(u);k&&!I&&(R=st.H.calc(e.toList(),W.o[u]()).data);const O=function(t,e,s){const i=[],n=[],r=[],o=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){r.push(l),o.push(l+h+1),a.add(l),a.add(l+h+1),i.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));n.push(1!=c?t/(1-c):1/0)}}return{simVals:i,saliVals:n,n1:r,n2:o,cliffsMolIds:a}}(await async function(t,e,s,i){const n=t.categories,o=t.getRawData(),a=r.Column.string("seq",t.length).init((t=>n[o[t]])),l=r.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const i=(0,it.y)(t);for(let n=0;n<t-1;++n){const o=new Float32Array(t-n-1).fill(0);for(let s=n+1;s<t;++s){const t=i(n,s);o[s-n-1]=e[t]===r.FLOAT_NULL?0:(0,D.Om)(e[t])}s[n]=r.Column.fromFloat32Array("similarity",o)}}(h,e,c):c=await i(h,t,l,"seq",c),c}(M,R,k,g),S,h),P=function(t,e,s,i,n,o){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(o.get(s[t])>o.get(i[t])?a[s[t]]+=e[t]:a[i[t]]+=e[t]);return r.Column.fromList("double",`sali_${n[0].substring(n[0].lastIndexOf("_"))}`,a)}(M.length,O.saliVals,O.n1,O.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",i=t.columns.names().filter((t=>t.includes(s))).length+1,n=`${s}_${i}`;return r.Column.bool(n,t.rowCount).init((t=>e.has(t)))}(t,O.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(O.saliVals),V=.8/(F.max-F.min),H=i.shell.getTableView(t.name);H.grid.columns.byName(G.name).visible=!1;const B=H.addViewer(r.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),Z=B.getInfo().canvas,U=function(t,e,s,i,n){const o=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],i=t.n2[e];o[e]={id:e,mols:[s,i],selected:!1,a:[],b:[]}}const a=r.DataFrame.create(o.length);return ut.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(o[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),n),a.col(t).semType=i})),a.columns.addNewFloat(at).init((t=>Math.abs(s.get(o[t].mols[0])-s.get(o[t].mols[1])))),a.columns.addNewInt(ct).init((t=>t)),a.columns.addNewFloat(lt).init((e=>t.saliVals[e])),a.columns.addNewFloat(ht).init((e=>t.simVals[e])),a.name=`${rt}${nt}`,{lines:o,linesDf:a}}(O,e,h,d,p),Y=b?b(U.linesDf,ut).sort([lt],[!1]):U.linesDf.plot.grid().sort([lt],[!1]);t.temp[".cliffsDfGrid"]=Y;const z=n.button(`${U.linesDf.rowCount} cliffs`,(()=>{H.dockManager.dock(Y,"down",null,"Activity cliffs",C??.2)}));z.classList.add("scatter_plot_link","cliffs_grid"),B.root.append(z);const X=n.switchInput("Show only 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h=H(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],n=[];let r=0;for(let e=0;e<t.rowCount;e++)s.includes(i[e])&&(t.rows.removeAt(e-r),n.push(e),r+=1);return n}(c,e),m={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},d=s===Vt.AL.UMAP?1e5:15e3,p=s===Vt.AL.UMAP?5e3:2e3;if(t.rowCount>d)i.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>p))return f(await V(m));n.dialog().add(n.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await V(m);return t.close(),f(e)})).show()}function f(e){const s=e.coordinates;for(const e of s){const s=e.toList();u.forEach((t=>s.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>s[t])))}if(a)return i.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function Be(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,re.n)(e,"To Atomic Level"))return;const s=(await Se()).getBioLib(),o=await(0,Tt.i0)(t,e,s);null!==o.col&&(t.columns.add(o.col,!0),await i.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&i.shell.warning(n.list(o.warnings))}function Ze(){(0,oe.K)()}async function Ue(t=null,e=null){return(0,oe.K)({col:t,clustersCol:e})}async function Ye(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(w.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,re.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const 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i.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{n+=1,e.update(100*n/s.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}function Je(t){const e=new le;n.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function Qe(t,e){await(0,he.n)(t,e)}function ts(t){const e=w.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function es(){return new Rt}function ss(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function is(){return new Ot}function ns(){const t=i.shell.v,e=t.addViewer("Sequence Diversity 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Promise.all([Ce.files.readCsv(Jt),$t(),jt()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,i){let n;{const t=Object.values(Ut);for(let s=0;s<t.length;s++){const i=t[s];if(!e.col(i)){const n=s==t.length-1;e.columns.add(r.Column.float(i,e.rowCount),n)}}if(e.rowCount>=1){const i=e.getCol(s).toList(),n=Date.now();Ce.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,P.I)(i,"UMAP",pt.W.Levenshtein,{}),o=Date.now();Ce.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-n)/1e3} s`);for(let s=0;s<t.length;s++){const i=t[s],n=e.getCol(i),o=r.embedding[s];n.init((t=>o[t]))}const a=Date.now();Ce.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}n=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Ut.X,yColumnName:Ut.Y,lassoTool:!0})}return t.dockManager.dock(n,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),n}(s,n,Qt)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol(Qt).toList(),r=st.H.calc(i,((t,e)=>Kt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{n.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of 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async function(){let t,e,s,n,o,a;const l="msa(HELM)",h=Vt.AL.UMAP;try{const c=new zt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await Ce.files.readCsv(ne)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=ie.J[0];n=await(0,ie.f)(s,l,t,1.53,0,void 0),e.columns.add(n),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await De(e,n,h,W.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Xt(t)}}()}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class n{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",i="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const n=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[n][e].parentJ}return new n(s,i,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let i=1;i<=this.len1;i++)for(let n=1;n<=this.len2;n++)this.fillOne(i,n),this.dpGrid[i][n].value<=0?(this.dpGrid[i][n].value=0,this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0):0==this.dpGrid[this.dpGrid[i][n].parentI][this.dpGrid[i][n].parentJ].value&&(this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0),this.dpGrid[i][n].value>t&&(t=this.dpGrid[i][n].value,e=i,s=n);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class g{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,i){this.pos=t,this.name=e,this._freqs=s??{},i?.rowCount&&(this.rowCount=i.rowCount),i?.sumForHeightCalc&&(this.sumForHeightCalc=i.sumForHeightCalc),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new g),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,i])=>i.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,i,n,o,a,l){const h=window.devicePixelRatio,c=s==u.ES.Entropy?e*(i-this.sumForHeightCalc)/i:e;let m=l*a+(e-c-1);const d=Object.entries(this._freqs).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const e of d){const s=e[1],i=c*s.count/this.rowCount;s.bounds=new r.Rect(t*h*n,m,o*h,i),m+=i}}render(t,e,s,i,n,r,o){for(const[a,l]of Object.entries(this._freqs))if("-"!==a){const h=(0,c.GU)(a,5),u=l.bounds,m=u.left-n*r;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(m,u.top,u.width,u.height),t.fillStyle=o.get(a)??o.get("other"),t.textAlign="left",t.font=e;const d=t.measureText(h);t.setTransform(u.width/d.width,0,0,u.height/i,m,u.top),t.fillText(h,0,-s)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const w=u.vS;var b;!function(t){t[t.None=0]="None",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(b||(b={}));class v extends r.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler?.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewSubs=[],this._onSizeChanged=new l.Subject,this.renderRequested=!1,this.recalcLevelRequested=b.Freqs,this.viewerId=v.viewerCount,v.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(p.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(p.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(p.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(p.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,w.fixWidth,{category:d.LAYOUT}),this.fitArea=this.bool(p.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(p.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(p.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(p.showPositionLabels,w.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=n.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=n.canvas(),this.canvas.style.width="100%"}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}buildView(){const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=n.div("No message"),this.msgHost.style.display="none",this.canvas=n.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=n.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.root.append(this.host),this.root.append(this.slider.root),this.updateSlider(),this.render(b.Freqs,"init"),this.error&&(this.msgHost.innerText=this.error.message,n.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.updateSlider(),this.render(b.Layout,"rootOnSizeChanged")}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(u.DX.positionNames),i=this.seqCol.getTag(u.DX.positionLabels);this.positionNames=s?s.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=i?i.split(u.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),s=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,s=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,s)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:this.updateSeqCol();break;case p.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case p.fixWidth:case p.fitArea:case p.positionMargin:this.updateSlider();break;case p.showPositionLabels:case p.shrinkEmptyTail:case p.skipEmptyPositions:this.updatePositions()}switch(t.name){case p.fixWidth:case p.fitArea:case p.showPositionLabels:case p.positionWidth:case p.positionMargin:this.render(b.Layout,"onPropertyChanged");break;default:this.render(b.Freqs,"onPropertyChanged")}}onTableAttached(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}get onSizeChanged(){return this._onSizeChanged}getMonomer(t,e){const s=t.x+this.firstVisibleIndex*this.positionWidthWithMargin*e,i=Math.floor(t.x/(this.positionWidthWithMargin*e)+this.firstVisibleIndex),n=this.positions[i];if(void 0===n)return[i,null,null];const r=n.getMonomerAt(s,t.y);return void 0===r?[i,null,null]:[i,r,n.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>!t.hasMonomer("-")||t.getFreq("-").count!==t.rowCount)).toArray())}render(t,e){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevel=${t}, reason='${e}' )`);const s=()=>{if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,i=this.dataFrame.rowCount,n=this.unitsHandler.splitted;for(let e=0;e<i;++e)if(s.get(e)){const s=n[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||"-";this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions()},n=(t,e)=>{f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const s=this.positions.length;this.calcSize();const n=this.canvas.height-e*t,r=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==r&&i.shell.error("WebLogo: alphabet is undefined.");const o=Math.log2(r);for(let i=0;i<s;i++)this.positions[i].calcScreen(i,n,this.positionHeight,o,this.positionWidthWithMargin,this._positionWidth,t,e)},o=t=>{if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio,o=this.showPositionLabels?12:0;t>=b.Freqs&&s(),t>=b.Layout&&n(window.devicePixelRatio,o);const a=this.Length;e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const l=this.countOfRenderPositions+1,h=this.visibleSlider?Math.floor(this.slider.min):0,c=Math.min(a,h+l),u=10*i;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${u.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const m=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),d=m<this._positionWidth*i-2?1:(this._positionWidth*i-2)/m;o>0&&function(t,e,s,i,n,r,o,a){for(let l=o;l<a;l++){const a=r[l];t.resetTransform(),t.setTransform(s,0,0,1,l*i*e+n*e/2-i*o,0),t.fillText(a.label,0,1)}}(e,i,d,this.positionWidthWithMargin,this._positionWidth,this.positions,this.firstVisibleIndex,c);for(let t=this.firstVisibleIndex;t<c;t++)this.positions[t].render(e,"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.positionWidthWithMargin,h,this.cp);f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};if(this.recalcLevelRequested=Math.max(this.recalcLevelRequested,t),!this.renderRequested)switch(this.renderRequested=!0,this.recalcLevelRequested){case b.Freqs:window.setTimeout((()=>{o(this.recalcLevelRequested),this.recalcLevelRequested=b.None,this.renderRequested=!1}),0);break;case b.Layout:case b.None:window.requestAnimationFrame((t=>{o(this.recalcLevelRequested),this.recalcLevelRequested=b.None,this.renderRequested=!1}))}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,s=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,s*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${s}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${s}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let n=0;switch(this.verticalAlignment){case"top":n=0;break;case"middle":n=Math.max(0,(this.root.clientHeight-s)/2);break;case"bottom":n=Math.max(0,this.root.clientHeight-s-t)}let r=0;switch(this.horizontalAlignment){case u.iD.LEFT:r=0;break;case u.iD.CENTER:r=Math.max(0,(this.root.clientWidth-e)/2);break;case u.iD.RIGHT:r=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${n}px`,"important"),this.host.style.setProperty("margin-left",`${r}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${n+i}px`,"important"),this.root.clientHeight<=s?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}this._lastWidth!==this.root.clientWidth&&this._lastHeight!==this.root.clientHeight&&(this._lastWidth=this.root.clientWidth,this._lastHeight=this.root.clientHeight,this._onSizeChanged.next())}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(b.Layout,"sliderOnValuesChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){f._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()");try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(b.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){f._package.logger.debug("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()");try{this.filterSource===u.Ct.Selected&&this.render(b.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,i=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(i,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,i,n){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=n.pos;(s<t.length?t[s]:null)===i&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),i=n.div([n.div(`${o}`),n.div(`${e} rows`)]);n.tooltip.show(i,s.x+16,s.y+16)}else n.tooltip.hide()}catch(t){const e=m(t);f._package.logger.error("Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[i,n]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&n){const t=this.positions[i],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,i,n,r){const 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e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class f{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class g extends f{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends g{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set 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