@datagrok/bio 2.4.8 → 2.4.10

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Files changed (9) hide show
  1. package/dist/package-test.js +1 -1
  2. package/dist/package-test.js.map +1 -1
  3. package/dist/package.js +1 -1
  4. package/dist/package.js.map +1 -1
  5. package/package.json +2 -2
  6. package/src/package.ts +15 -11
  7. package/src/tests/WebLogo-positions-test.ts +1 -2
  8. package/src/viewers/vd-regions-viewer.ts +2 -2
  9. package/src/viewers/web-logo-viewer.ts +23 -42
package/dist/package-test.js CHANGED
@@ -1,2 +1,2 @@
1
- var bio_test;(()=>{var t={2012:(t,e,n)=>{"use strict";n.d(e,{f:()=>o});var i=n(9976);class o extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,o)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,o)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new o({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in o.aaSynonyms?o.aaSynonyms[t]:t;return super.get(e)}}o.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class s{static getPalette(t="grok"){switch(t){case"grok":return o.GrokGroups;case"lesk":return o.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const o of t)"("==o?e++:")"==o?e--:e?n+=o:i+=o;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){var n,i,o;const s=this.getPalette(e);let[r,a]=this.getInnerOuter(t);if(r=r.length>6?`${r.slice(0,3)}...`:r,a=a.length>6?`${a.slice(0,3)}...`:a,1==t.length||"("==t[1]){const e=null===(n=t[0])||void 0===n?void 0:n.toUpperCase();return e in s?[s.get(e),e,a,1]:[this.undefinedColor,r,a,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=null===(i=t[1])||void 0===i?void 0:i.toUpperCase();return e in s?[s.get(e),e,a,2]:[this.undefinedColor,r,a,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,a,3]:[this.undefinedColor,r,a,3]}if((null===(o=t[0])||void 0===o?void 0:o.toLowerCase())==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,a,4]:[this.undefinedColor,r,a,4]}return[this.undefinedColor,r,a,0]}}s.SemType="Aminoacids",s.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",s.undefinedColor="rgb(100,100,100)",s.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},s.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},s.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},s.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,n)=>{"use strict";n.d(e,{DC:()=>r,JN:()=>l,Xk:()=>a});var i=n(976),o=(n(4469),n(1047)),s=(n(6714),function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))});const r=["symbol","name","molfile","rgroups","polymerType","monomerType"];function a(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(o.K4).forEach((e=>{if("symbol"===e){const s=t.get(o.K4[e],n);i[e]="."===s?t.get(o.At,n):s}else if("rgroups"===e){const s=t.get(o.K4[e],n).split("\n"),r=[];s.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,r.push(e)})),i[e]=r}else o.K4[e]&&(i[e]=t.get(o.K4[e],n))})),e.push(i)}return e}function l(){return s(this,void 0,void 0,(function*(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installer for MonomerLibraryHelper.');return(yield t[0].prepare().call()).getOutputParamValue()}))}},6137:(t,e,n)=>{"use strict";n.d(e,{J:()=>o,V:()=>s});var i=n(9976);class o extends i.B{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new o({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class s{}s.SemType="Nucleotides",s.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",s.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},9976:(t,e,n)=>{"use strict";n.d(e,{B:()=>i});class i{static makePalette(t,e=!1,n=i){const o={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{o[t]=this.colourPalette[i][e?0:n]}))})),new n(o)}constructor(t){this._palette=t}get(t){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},7331:(t,e,n)=>{"use strict";n.d(e,{UE:()=>h,kQ:()=>r});var i=n(976),o=n(9976);class s{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class r{}class a extends r{get(t){return"#666666"}}class l extends r{static buildPalette(){return[].concat(...Object.values(o.B.colourPalette))}get(t){const e=s.hashCode(t)%l.palette.length;return function(t){if(null==t)return"rgb(100,100,100)";const e=i.Color.fromHtml(t),n=i.Color.g(e),o=i.Color.r(e),s=i.Color.b(e),r=Math.sqrt(Math.pow(0-o,2)+Math.pow(0-n,2)+Math.pow(0-s,2));return r>210?`rgb(${o/r*210},${n/r*210},${s/r*210})`:i.Color.toRgb(e)}(l.palette[e])}}l.palette=l.buildPalette();class h extends o.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},1047:(t,e,n)=>{"use strict";n.d(e,{At:()=>i,K4:()=>o});const i="MonomerName",o={monomerType:null,smiles:null,name:"MonomerName",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerCode"}},5226:(t,e,n)=>{"use strict";n.d(e,{i:()=>s});var i=n(976),o=n(499);class s{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,o.C.setUnitsToFastaColumn(e),[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6714:(t,e,n)=>{"use strict";n.d(e,{GU:()=>C,KX:()=>T,Mj:()=>w,dQ:()=>E,fy:()=>d,gM:()=>S,gP:()=>v,kB:()=>m,py:()=>A,up:()=>R,vU:()=>y,w4:()=>M});var i=n(976),o=n(6414),s=n.n(o),r=n(3659),a=n(850),l=n(2012),h=n(6137),u=n(7331),c=n(499);function d(t,e,n){const i={};let o=!0,s=null;for(const r of t.categories){const t=n(r);if(null==s?s=t.length:t.length!==s&&(o=!1),t.length>=e)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:o}}const f=/\[(\w+)\]|(\w)|(-)/g;function m(t){return s()(t.toString().matchAll(f)).map((t=>{let e;const n=t[0];return e=n.length>1?t[1]:n,e})).toArray()}const p=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,g=/\[([^\[\]]+)]/g;function v(t){p.lastIndex=0;const e=p.exec(t.toString()),n=e?e[2]:null;return(n?n.split("."):[]).map((t=>{g.lastIndex=0;const e=g.exec(t);return e&&e.length>=2?e[1]:t}))}function y(t,e,n=undefined){if(t.toLowerCase().startsWith("fasta"))return m;if(t.toLowerCase().startsWith("separator"))return function(t,e=undefined){return n=>n.split(t,e)}(e,n);if(t.toLowerCase().startsWith("helm"))return v;throw new Error(`Unexpected units ${t} .`)}function w(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`Get splitter for semType "${i.SEMTYPE.MACROMOLECULE}" only.`);return y(t.getTag(i.TAGS.UNITS),t.getTag("separator"))}const b=/(\w+)/g;function C(t,e){var n,i;const o=t.match(b),s=t.length>e||(null!==(n=null==o?void 0:o.length)&&void 0!==n?n:0)>1,r=null!==(i=null==o?void 0:o[0])&&void 0!==i?i:" ";return s?r.substring(0,e)+"…":r}function S(t){switch(t){case"DNA":return c.C.DnaFastaAlphabet;case"RNA":return c.C.RnaFastaAlphabet;case"PT":return c.C.PeptideFastaAlphabet;default:throw new Error(`Unsupported alphabet '${t}'.`)}}function T(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const o=[],s=[];for(const n of i)o.push(n in t?t[n]:0),s.push(e.has(n)?1:0);const l=new r.OW(o),h=new r.OW(s);return(0,a.MA)(l,h)/((0,a.$G)(l)*(0,a.$G)(h))}function M(t){const e=[["PT",c.C.PeptideFastaAlphabet],["DNA",c.C.DnaFastaAlphabet],["RNA",c.C.RnaFastaAlphabet]],n=e.map((e=>T(t.freq,e[1]))),i=Math.max(...n);return i>.65?e[n.indexOf(i)][0]:"UN"}function E(t,e=5){let n;return n=t.semType==i.SEMTYPE.MACROMOLECULE?new c.C(t).alphabet:M(d(t,e,m)),A(n)}function A(t){switch(t){case"PT":return l.f.GrokGroups;case"NT":case"DNA":case"RNA":return h.J.Chromatogram;default:return u.UE.Color}}function R(t){var e;const n=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let o=null!==(e=n.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")})))&&void 0!==e?e:null;return!o&&n.length>0&&(o=n[0]),o}},7767:(t,e,n)=>{"use strict";n.d(e,{L:()=>r});var i=n(976),o=n(499),s=n(6714);class r extends o.C{get splitter(){return null===this._splitter&&(this._splitter=(0,s.Mj)(this.column)),this._splitter}toFasta(t){return"fasta"===t}toSeparator(t){return"separator"===t}toHelm(t){return"helm"===t}convertFastaToSeparator(t,e=null){null===e&&(e=this.defaultGapSymbol);const n=this.getNewColumn("separator");return n.init((n=>{const i=this.column.get(n),s=this.splitter(i);for(let t=0;t<s.length;t++)s[t]===e&&(s[t]=o.C._defaultGapSymbolsDict.SEPARATOR);return s.join(t)})),n.setTag(i.TAGS.UNITS,"separator"),n.setTag("separator",t),n}getHelmWrappers(){const t=this.isDna()?"DNA1{":this.isRna()?"RNA1{":this.isPeptide()?"PEPTIDE1{":"Unknown";if("Unknown"===t)throw new Error("Neither peptide, nor nucleotide");return[t,this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$"]}convertToHelmHelper(t,e,n,i,s,r){return`${n}${this.splitter(t).map((t=>t===e?o.C._defaultGapSymbolsDict.HELM:`${i}${t}${s}`)).join(".")}${r}`}convertStringToHelm(t,e=null){null===e&&(e=this.defaultGapSymbol);const[n,i,o,s]=this.getHelmWrappers();return this.convertToHelmHelper(t,e,n,i,o,s)}convertToHelm(t=null){null===t&&(t=this.defaultGapSymbol);const[e,n,o,s]=this.getHelmWrappers(),r=this.getNewColumn("helm");return r.init((i=>{const r=this.column.get(i);return this.convertToHelmHelper(r,t,e,n,o,s)})),r.setTag(i.TAGS.UNITS,"helm"),r}convertSeparatorToFasta(t=null){null===t&&(t=o.C._defaultGapSymbolsDict.FASTA);const e=this.getNewColumn("fasta");return e.init((e=>{const n=this.column.get(e),i=this.splitter(n),o=[];for(let e=0;e<i.length;e++){const n=i[e];if(0===n.length)o.push(t);else if(n.length>1){const t="["+n+"]";o.push(t)}else o.push(n)}return o.join("")})),e.setTag(i.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?o.C._defaultGapSymbolsDict.FASTA:o.C._defaultGapSymbolsDict.SEPARATOR),n||(n=this.toFasta(e)?"":this.separator);const s=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let n=a[t];if(r&&(n=n.replace(s,"")),n===o.C._defaultGapSymbolsDict.HELM)l.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";l.push(t)}else l.push(n)}return l.join(n)}convertHelm(t,e,n){const i=this.getNewColumn(t);i.init((i=>{const o=this.column.get(i);return this.convertHelmToFastaSeparator(o,t,e,n)}));const o=(0,s.Mj)(i),r=(0,s.fy)(i,5,o).sameLength?"SEQ.MSA":"SEQ";return i.setTag("aligned",r),i}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,n)=>{"use strict";n.d(e,{C:()=>s});var i=n(976),o=n(6714);class s{static setUnitsToFastaColumn(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error("Fasta column must be MACROMOLECULE");const e=(0,o.fy)(t,5,o.kB),n=e.sameLength?"SEQ.MSA":"SEQ",s=(0,o.w4)(e);t.setTag(i.TAGS.UNITS,"fasta"),t.setTag("aligned",n),t.setTag("alphabet",s)}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){var t;const e=null!==(t=this.column.getTag("separator"))&&void 0!==t?t:void 0;if("separator"===this.notation&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=(0,o.Mj)(this.column),n=(0,o.fy)(this.column,1,t);e=Object.keys(n.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return("helm"==this.notation||"UN"==this.alphabet)&&"true"==this.column.getTag(".alphabetIsMultichar")}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t){const e=this.column,n=e.length,o=t.toLowerCase()+"("+e.name+")",s=e.dataFrame.columns.getUnusedName(o),r=i.Column.fromList("string",s,new Array(n).fill(""));r.semType=i.SEMTYPE.MACROMOLECULE,r.setTag(i.TAGS.UNITS,t),r.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const a=e.getTag("aligned");a&&r.setTag("aligned",a);const l=e.getTag("alphabet");l&&r.setTag("alphabet",l);let h=e.getTag(".alphabetSize");h&&r.setTag(".alphabetSize",h);const u=e.getTag(".alphabetIsMultichar");return void 0!==u&&r.setTag(".alphabetIsMultichar",u),"helm"==t&&(h=this.getAlphabetSize().toString(),r.setTag(".alphabetSize",h)),r}static getNewColumn(t){const e=new s(t),n=e.notation;return e.getNewColumn(n)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!s.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const o=i.Column.fromList("string",e,new Array(t).fill(""));return o.semType=i.SEMTYPE.MACROMOLECULE,o.setTag(i.TAGS.UNITS,n),o}constructor(t){this._column=t;const e=this._column.tags[i.TAGS.UNITS];if(null===e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?s._defaultGapSymbolsDict.FASTA:this.isHelm()?s._defaultGapSymbolsDict.HELM:s._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")&&(this.isFasta()||this.isSeparator()))throw new Error(`For column '${this.column.name}' of notation '${this.notation}' tag 'aligned' is mandatory.`);if(!this.column.tags.has(".alphabetIsMultichar")){if(this.isHelm())throw new Error(`For column '${this.column.name}' of notation '${this.notation}' tag '.alphabetIsMultichar' is mandatory.`);if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}}}s._defaultGapSymbolsDict={HELM:"*",SEPARATOR:"",FASTA:"-"},s.PeptideFastaAlphabet=new 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P(n,i);for(let s=0;s<n;s++)for(let n=0;n<i;n++)o.set(s,n,Math.min(t.get(s,n),e.get(s,n)));return o}static max(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let n=t.rows,i=t.columns,o=new this(n,i);for(let s=0;s<n;s++)for(let n=0;n<i;n++)o.set(s,n,Math.max(t.get(s,n),e.get(s,n)));return o}static checkMatrix(t){return A.isMatrix(t)?t:new P(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.call(this,e,n);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.push(this.get(e,n));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let n=0;n<this.columns;n++)t[e].push(this.get(e,n))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 1===this.rows||1===this.columns}isSquare(){return this.rows===this.columns}isEmpty(){return 0===this.rows||0===this.columns}isSymmetric(){if(this.isSquare()){for(let t=0;t<this.rows;t++)for(let e=0;e<=t;e++)if(this.get(t,e)!==this.get(e,t))return!1;return!0}return!1}isEchelonForm(){let t=0,e=0,n=-1,i=!0,o=!1;for(;t<this.rows&&i;){for(e=0,o=!1;e<this.columns&&!1===o;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>n?(o=!0,n=e):(i=!1,o=!0);t++}return i}isReducedEchelonForm(){let t=0,e=0,n=-1,i=!0,o=!1;for(;t<this.rows&&i;){for(e=0,o=!1;e<this.columns&&!1===o;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>n?(o=!0,n=e):(i=!1,o=!0);for(let n=e+1;n<this.rows;n++)0!==this.get(t,n)&&(i=!1);t++}return i}echelonForm(){let t=this.clone(),e=0,n=0;for(;e<t.rows&&n<t.columns;){let i=e;for(let o=e;o<t.rows;o++)t.get(o,n)>t.get(i,n)&&(i=o);if(0===t.get(i,n))n++;else{t.swapRows(e,i);let o=t.get(e,n);for(let i=n;i<t.columns;i++)t.set(e,i,t.get(e,i)/o);for(let i=e+1;i<t.rows;i++){let o=t.get(i,n)/t.get(e,n);t.set(i,n,0);for(let s=n+1;s<t.columns;s++)t.set(i,s,t.get(i,s)-t.get(e,s)*o)}e++,n++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,n=t.rows,i=n-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let o=0,s=!1;for(;o<n&&!1===s;)1===t.get(i,o)?s=!0:o++;for(let n=0;n<i;n++){let s=t.get(n,o);for(let r=o;r<e;r++){let e=t.get(n,r)-s*t.get(i,r);t.set(n,r,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:n=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(n)||n<=0)throw new TypeError("columns must be a positive integer");let i=new P(this.rows*e,this.columns*n);for(let t=0;t<e;t++)for(let e=0;e<n;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,t);return this}neg(){return this.mulS(-1)}getRow(t){y(this,t);let e=[];for(let n=0;n<this.columns;n++)e.push(this.get(t,n));return e}getRowVector(t){return P.rowVector(this.getRow(t))}setRow(t,e){y(this,t),e=b(this,e);for(let n=0;n<this.columns;n++)this.set(t,n,e[n]);return this}swapRows(t,e){y(this,t),y(this,e);for(let n=0;n<this.columns;n++){let i=this.get(t,n);this.set(t,n,this.get(e,n)),this.set(e,n,i)}return this}getColumn(t){w(this,t);let e=[];for(let n=0;n<this.rows;n++)e.push(this.get(n,t));return e}getColumnVector(t){return P.columnVector(this.getColumn(t))}setColumn(t,e){w(this,t),e=C(this,e);for(let n=0;n<this.rows;n++)this.set(n,t,e[n]);return this}swapColumns(t,e){w(this,t),w(this,e);for(let n=0;n<this.rows;n++){let i=this.get(n,t);this.set(n,t,this.get(n,e)),this.set(n,e,i)}return this}addRowVector(t){t=b(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t[n]);return this}subRowVector(t){t=b(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t[n]);return this}mulRowVector(t){t=b(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t[n]);return this}divRowVector(t){t=b(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t[n]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t[e]);return this}mulRow(t,e){y(this,t);for(let n=0;n<this.columns;n++)this.set(t,n,this.get(t,n)*e);return this}mulColumn(t,e){w(this,t);for(let n=0;n<this.rows;n++)this.set(n,t,this.get(n,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)>t[e]&&(t[e]=this.get(e,n));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)>t[n]&&(t[n]=this.get(e,n));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)>t&&(t=this.get(e,n));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){E(this);let t=this.get(0,0),e=[0,0];for(let n=0;n<this.rows;n++)for(let i=0;i<this.columns;i++)this.get(n,i)>t&&(t=this.get(n,i),e[0]=n,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[e]&&(t[e]=this.get(e,n));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[n]&&(t[n]=this.get(e,n));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t&&(t=this.get(e,n));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){E(this);let t=this.get(0,0),e=[0,0];for(let n=0;n<this.rows;n++)for(let i=0;i<this.columns;i++)this.get(n,i)<t&&(t=this.get(n,i),e[0]=n,e[1]=i);return e}maxRow(t){if(y(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n));return e}maxRowIndex(t){y(this,t),E(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),n[1]=i);return n}minRow(t){if(y(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n));return e}minRowIndex(t){y(this,t),E(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),n[1]=i);return n}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t));return e}maxColumnIndex(t){w(this,t),E(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),n[0]=i);return n}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t));return e}minColumnIndex(t){w(this,t),E(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),n[0]=i);return n}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let n=0;n<t;n++)e.push(this.get(n,n));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let n=0;n<this.columns;n++)e+=this.get(t,n)*this.get(t,n);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t+=this.get(e,n),this.set(e,n,t);return this}dot(t){A.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}mmul(t){t=P.checkMatrix(t);let e=this.rows,n=this.columns,i=t.columns,o=new P(e,i),s=new Float64Array(n);for(let r=0;r<i;r++){for(let e=0;e<n;e++)s[e]=t.get(e,r);for(let t=0;t<e;t++){let e=0;for(let i=0;i<n;i++)e+=this.get(t,i)*s[i];o.set(t,r,e)}}return o}strassen2x2(t){t=P.checkMatrix(t);let e=new P(2,2);const n=this.get(0,0),i=t.get(0,0),o=this.get(0,1),s=t.get(0,1),r=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),u=(n+l)*(i+h),c=(r+l)*i,d=n*(s-h),f=l*(a-i),m=(n+o)*h,p=u+f-m+(o-l)*(a+h),g=d+m,v=c+f,y=u-c+d+(r-n)*(i+s);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,v),e.set(1,1,y),e}strassen3x3(t){t=P.checkMatrix(t);let e=new P(3,3);const n=this.get(0,0),i=this.get(0,1),o=this.get(0,2),s=this.get(1,0),r=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),u=this.get(2,2),c=t.get(0,0),d=t.get(0,1),f=t.get(0,2),m=t.get(1,0),p=t.get(1,1),g=t.get(1,2),v=t.get(2,0),y=t.get(2,1),w=t.get(2,2),b=(n-s)*(-d+p),C=(-n+s+r)*(c-d+p),S=(s+r)*(-c+d),T=n*c,M=(-n+l+h)*(c-f+g),E=(-n+l)*(f-g),A=(l+h)*(-c+f),R=(-o+h+u)*(p+v-y),N=(o-u)*(p-y),x=o*v,L=(h+u)*(-v+y),G=(-o+r+a)*(g+v-w),_=(o-a)*(g-w),I=(r+a)*(-v+w),W=T+x+i*m,F=(n+i+o-s-r-h-u)*p+C+S+T+R+x+L,k=T+M+A+(n+i+o-r-a-l-h)*g+x+G+I,D=b+r*(-c+d+m-p-g-v+w)+C+T+x+G+_,V=b+C+S+T+a*y,H=x+G+_+I+s*f,O=T+M+E+h*(-c+f+m-p-g-v+y)+R+N+x,Y=R+N+x+L+l*d,U=T+M+E+A+u*w;return e.set(0,0,W),e.set(0,1,F),e.set(0,2,k),e.set(1,0,D),e.set(1,1,V),e.set(1,2,H),e.set(2,0,O),e.set(2,1,Y),e.set(2,2,U),e}mmulStrassen(t){t=P.checkMatrix(t);let e=this.clone(),n=e.rows,i=e.columns,o=t.rows,s=t.columns;function r(t,e,n){let i=t.rows,o=t.columns;if(i===e&&o===n)return t;{let i=A.zeros(e,n);return i=i.setSubMatrix(t,0,0),i}}i!==o&&console.warn(`Multiplying ${n} x ${i} and ${o} x ${s} matrix: dimensions do not match.`);let a=Math.max(n,o),l=Math.max(i,s);return e=r(e,a,l),function t(e,n,i,o){if(i<=512||o<=512)return e.mmul(n);i%2==1&&o%2==1?(e=r(e,i+1,o+1),n=r(n,i+1,o+1)):i%2==1?(e=r(e,i+1,o),n=r(n,i+1,o)):o%2==1&&(e=r(e,i,o+1),n=r(n,i,o+1));let s=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,s-1,0,a-1),h=n.subMatrix(0,s-1,0,a-1),u=e.subMatrix(0,s-1,a,e.columns-1),c=n.subMatrix(0,s-1,a,n.columns-1),d=e.subMatrix(s,e.rows-1,0,a-1),f=n.subMatrix(s,n.rows-1,0,a-1),m=e.subMatrix(s,e.rows-1,a,e.columns-1),p=n.subMatrix(s,n.rows-1,a,n.columns-1),g=t(A.add(l,m),A.add(h,p),s,a),v=t(A.add(d,m),h,s,a),y=t(l,A.sub(c,p),s,a),w=t(m,A.sub(f,h),s,a),b=t(A.add(l,u),p,s,a),C=t(A.sub(d,l),A.add(h,c),s,a),S=t(A.sub(u,m),A.add(f,p),s,a),T=A.add(g,w);T.sub(b),T.add(S);let M=A.add(y,b),E=A.add(v,w),R=A.sub(g,v);R.add(y),R.add(C);let P=A.zeros(2*T.rows,2*T.columns);return P=P.setSubMatrix(T,0,0),P=P.setSubMatrix(M,T.rows,0),P=P.setSubMatrix(E,0,T.columns),P=P.setSubMatrix(R,T.rows,T.columns),P.subMatrix(0,i-1,0,o-1)}(e,t=r(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new P(this.rows,this.columns);for(let t=0;t<this.rows;t++){const o=this.getRow(t);o.length>0&&d(o,{min:e,max:n,output:o}),i.setRow(t,o)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new P(this.rows,this.columns);for(let t=0;t<this.columns;t++){const o=this.getColumn(t);o.length&&d(o,{min:e,max:n,output:o}),i.setColumn(t,o)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let n=0;n<t;n++){let t=this.get(e,n),i=this.get(e,this.columns-1-n);this.set(e,n,i),this.set(e,this.columns-1-n,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let n=0;n<t;n++){let t=this.get(n,e),i=this.get(this.rows-1-n,e);this.set(n,e,i),this.set(this.rows-1-n,e,t)}return this}kroneckerProduct(t){t=P.checkMatrix(t);let e=this.rows,n=this.columns,i=t.rows,o=t.columns,s=new P(e*i,n*o);for(let r=0;r<e;r++)for(let e=0;e<n;e++)for(let n=0;n<i;n++)for(let a=0;a<o;a++)s.set(i*r+n,o*e+a,this.get(r,e)*t.get(n,a));return s}kroneckerSum(t){if(t=P.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,n=t.rows,i=this.kroneckerProduct(P.eye(n,n)),o=P.eye(e,e).kroneckerProduct(t);return i.add(o)}transpose(){let t=new P(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(n,e,this.get(e,n));return t}sortRows(t=R){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=R){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,n,i){S(this,t,e,n,i);let o=new P(e-t+1,i-n+1);for(let s=t;s<=e;s++)for(let e=n;e<=i;e++)o.set(s-t,e-n,this.get(s,e));return o}subMatrixRow(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.columns-1),e>n||e<0||e>=this.columns||n<0||n>=this.columns)throw new RangeError("Argument out of range");let i=new P(t.length,n-e+1);for(let o=0;o<t.length;o++)for(let s=e;s<=n;s++){if(t[o]<0||t[o]>=this.rows)throw new RangeError(`Row index out of range: ${t[o]}`);i.set(o,s-e,this.get(t[o],s))}return i}subMatrixColumn(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.rows-1),e>n||e<0||e>=this.rows||n<0||n>=this.rows)throw new RangeError("Argument out of range");let i=new P(n-e+1,t.length);for(let o=0;o<t.length;o++)for(let s=e;s<=n;s++){if(t[o]<0||t[o]>=this.columns)throw new RangeError(`Column index out of range: ${t[o]}`);i.set(s-e,o,this.get(s,t[o]))}return i}setSubMatrix(t,e,n){if((t=P.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,n,n+t.columns-1);for(let i=0;i<t.rows;i++)for(let o=0;o<t.columns;o++)this.set(e+i,n+o,t.get(i,o));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let n=new P(t.length,e.length);for(let i=0;i<t.length;i++){let o=t[i];for(let t=0;t<e.length;t++){let s=e[t];n.set(i,t,this.get(o,s))}}return n}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let n=0;n<t;n++)e+=this.get(n,n);return e}clone(){let t=new P(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(e,n,this.get(e,n));return t}sum(t){switch(t){case"row":return function(t){let e=T(t.rows);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]+=t.get(n,i);return e}(this);case"column":return function(t){let e=T(t.columns);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]+=t.get(n,i);return e}(this);case void 0:return function(t){let e=0;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e+=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=T(t.rows,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]*=t.get(n,i);return e}(this);case"column":return function(t){let e=T(t.columns,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]*=t.get(n,i);return e}(this);case void 0:return function(t){let e=1;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e*=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:n=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof n)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,o=t.columns,s=[];for(let r=0;r<i;r++){let i=0,a=0,l=0;for(let e=0;e<o;e++)l=t.get(r,e)-n[r],i+=l,a+=l*l;e?s.push((a-i*i/o)/(o-1)):s.push((a-i*i/o)/o)}return s}(this,n,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,o=t.columns,s=[];for(let r=0;r<o;r++){let o=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,r)-n[r],o+=l,a+=l*l;e?s.push((a-o*o/i)/(i-1)):s.push((a-o*o/i)/i)}return s}(this,n,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,n){const i=t.rows,o=t.columns,s=i*o;let r=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<o;i++)l=t.get(e,i)-n,r+=l,a+=l*l;return e?(a-r*r/s)/(s-1):(a-r*r/s)/s}(this,n,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const n=this.variance(t,e);if(void 0===t)return Math.sqrt(n);for(let t=0;t<n.length;t++)n[t]=Math.sqrt(n[t]);return n}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:n=this.mean(t)}=e;switch(t){case"row":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[n])}(this,n),this;case"column":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[i])}(this,n),this;case void 0:if("number"!=typeof n)throw new TypeError("center must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let n=e.scale;switch(t){case"row":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.rows;n++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(n,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[n])}(this,n),this;case"column":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.columns;n++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,n),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[i])}(this,n),this;case void 0:if(void 0===n)n=function(t){const e=t.size-1;let n=0;for(let i=0;i<t.columns;i++)for(let o=0;o<t.rows;o++)n+=Math.pow(t.get(o,i),2)/e;return Math.sqrt(n)}(this);else if("number"!=typeof n)throw new TypeError("scale must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function R(t,e){return t-e}A.prototype.klass="Matrix","undefined"!=typeof Symbol&&(A.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),A.random=A.rand,A.randomInt=A.randInt,A.diagonal=A.diag,A.prototype.diagonal=A.prototype.diag,A.identity=A.eye,A.prototype.negate=A.prototype.neg,A.prototype.tensorProduct=A.prototype.kroneckerProduct;class P extends A{constructor(t,e){if(super(),P.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let n=0;n<t;n++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const n=t;if("number"!=typeof(e=(t=n.length)?n[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(n[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!n[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(n[i]))}}}this.rows=t,this.columns=e}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}removeRow(t){return y(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),y(this,t,!0),e=Float64Array.from(b(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const n=new Float64Array(this.columns-1);for(let i=0;i<t;i++)n[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)n[i-1]=this.data[e][i];this.data[e]=n}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=C(this,e);for(let n=0;n<this.rows;n++){const i=new Float64Array(this.columns+1);let o=0;for(;o<t;o++)i[o]=this.data[n][o];for(i[o++]=e[n];o<this.columns+1;o++)i[o]=this.data[n][o-1];this.data[n]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t.get(e,n));return this},t.add=function(t,n){return new e(t).add(n)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t.get(e,n));return this},t.sub=function(t,n){return new e(t).sub(n)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t.get(e,n));return this},t.mul=function(t,n){return new e(t).mul(n)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t.get(e,n));return this},t.div=function(t,n){return new e(t).div(n)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t.get(e,n));return this},t.mod=function(t,n){return new e(t).mod(n)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t.get(e,n));return this},t.and=function(t,n){return new e(t).and(n)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t.get(e,n));return this},t.or=function(t,n){return new e(t).or(n)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t.get(e,n));return this},t.xor=function(t,n){return new e(t).xor(n)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t.get(e,n));return this},t.leftShift=function(t,n){return new e(t).leftShift(n)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t.get(e,n));return this},t.signPropagatingRightShift=function(t,n){return new e(t).signPropagatingRightShift(n)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t.get(e,n));return this},t.rightShift=function(t,n){return new e(t).rightShift(n)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,n){return new e(t).pow(n)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t.get(e,n)));return this}}(A,P);class N extends A{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}}class x{constructor(t){let e,n,i,o,s,r,a,l,h,u=(t=N.checkMatrix(t)).clone(),c=u.rows,d=u.columns,f=new Float64Array(c),m=1;for(e=0;e<c;e++)f[e]=e;for(l=new Float64Array(c),n=0;n<d;n++){for(e=0;e<c;e++)l[e]=u.get(e,n);for(e=0;e<c;e++){for(h=Math.min(e,n),s=0,i=0;i<h;i++)s+=u.get(e,i)*l[i];l[e]-=s,u.set(e,n,l[e])}for(o=n,e=n+1;e<c;e++)Math.abs(l[e])>Math.abs(l[o])&&(o=e);if(o!==n){for(i=0;i<d;i++)r=u.get(o,i),u.set(o,i,u.get(n,i)),u.set(n,i,r);a=f[o],f[o]=f[n],f[n]=a,m=-m}if(n<c&&0!==u.get(n,n))for(e=n+1;e<c;e++)u.set(e,n,u.get(e,n)/u.get(n,n))}this.LU=u,this.pivotVector=f,this.pivotSign=m}isSingular(){let t=this.LU,e=t.columns;for(let n=0;n<e;n++)if(0===t.get(n,n))return!0;return!1}solve(t){t=P.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let n,i,o,s=t.columns,r=t.subMatrixRow(this.pivotVector,0,s-1),a=e.columns;for(o=0;o<a;o++)for(n=o+1;n<a;n++)for(i=0;i<s;i++)r.set(n,i,r.get(n,i)-r.get(o,i)*e.get(n,o));for(o=a-1;o>=0;o--){for(i=0;i<s;i++)r.set(o,i,r.get(o,i)/e.get(o,o));for(n=0;n<o;n++)for(i=0;i<s;i++)r.set(n,i,r.get(n,i)-r.get(o,i)*e.get(n,o))}return r}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,n=t.columns;for(let i=0;i<n;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new P(e,n);for(let o=0;o<e;o++)for(let e=0;e<n;e++)o>e?i.set(o,e,t.get(o,e)):o===e?i.set(o,e,1):i.set(o,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new P(e,n);for(let o=0;o<e;o++)for(let e=0;e<n;e++)o<=e?i.set(o,e,t.get(o,e)):i.set(o,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function L(t,e){let n=0;return Math.abs(t)>Math.abs(e)?(n=e/t,Math.abs(t)*Math.sqrt(1+n*n)):0!==e?(n=t/e,Math.abs(e)*Math.sqrt(1+n*n)):0}class G{constructor(t){let e,n,i,o,s=(t=N.checkMatrix(t)).clone(),r=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<r;e++)t=L(t,s.get(e,i));if(0!==t){for(s.get(i,i)<0&&(t=-t),e=i;e<r;e++)s.set(e,i,s.get(e,i)/t);for(s.set(i,i,s.get(i,i)+1),n=i+1;n<a;n++){for(o=0,e=i;e<r;e++)o+=s.get(e,i)*s.get(e,n);for(o=-o/s.get(i,i),e=i;e<r;e++)s.set(e,n,s.get(e,n)+o*s.get(e,i))}}l[i]=-t}this.QR=s,this.Rdiag=l}solve(t){t=P.checkMatrix(t);let e=this.QR,n=e.rows;if(t.rows!==n)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,o,s,r,a=t.columns,l=t.clone(),h=e.columns;for(s=0;s<h;s++)for(o=0;o<a;o++){for(r=0,i=s;i<n;i++)r+=e.get(i,s)*l.get(i,o);for(r=-r/e.get(s,s),i=s;i<n;i++)l.set(i,o,l.get(i,o)+r*e.get(i,s))}for(s=h-1;s>=0;s--){for(o=0;o<a;o++)l.set(s,o,l.get(s,o)/this.Rdiag[s]);for(i=0;i<s;i++)for(o=0;o<a;o++)l.set(i,o,l.get(i,o)-l.get(s,o)*e.get(i,s))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,n=this.QR,i=n.columns,o=new P(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?o.set(t,e,n.get(t,e)):t===e?o.set(t,e,this.Rdiag[t]):o.set(t,e,0);return o}get orthogonalMatrix(){let t,e,n,i,o=this.QR,s=o.rows,r=o.columns,a=new P(s,r);for(n=r-1;n>=0;n--){for(t=0;t<s;t++)a.set(t,n,0);for(a.set(n,n,1),e=n;e<r;e++)if(0!==o.get(n,n)){for(i=0,t=n;t<s;t++)i+=o.get(t,n)*a.get(t,e);for(i=-i/o.get(n,n),t=n;t<s;t++)a.set(t,e,a.get(t,e)+i*o.get(t,n))}}return a}}class _{constructor(t,e={}){if((t=N.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let n=t.rows,i=t.columns;const{computeLeftSingularVectors:o=!0,computeRightSingularVectors:s=!0,autoTranspose:r=!1}=e;let a,l=Boolean(o),h=Boolean(s),u=!1;if(n<i)if(r){a=t.transpose(),n=a.rows,i=a.columns,u=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let c=Math.min(n,i),d=Math.min(n+1,i),f=new Float64Array(d),m=new P(n,c),p=new P(i,i),g=new Float64Array(i),v=new Float64Array(n),y=new Float64Array(d);for(let t=0;t<d;t++)y[t]=t;let w=Math.min(n-1,i),b=Math.max(0,Math.min(i-2,n)),C=Math.max(w,b);for(let t=0;t<C;t++){if(t<w){f[t]=0;for(let e=t;e<n;e++)f[t]=L(f[t],a.get(e,t));if(0!==f[t]){a.get(t,t)<0&&(f[t]=-f[t]);for(let e=t;e<n;e++)a.set(e,t,a.get(e,t)/f[t]);a.set(t,t,a.get(t,t)+1)}f[t]=-f[t]}for(let e=t+1;e<i;e++){if(t<w&&0!==f[t]){let i=0;for(let o=t;o<n;o++)i+=a.get(o,t)*a.get(o,e);i=-i/a.get(t,t);for(let o=t;o<n;o++)a.set(o,e,a.get(o,e)+i*a.get(o,t))}g[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<n;e++)m.set(e,t,a.get(e,t));if(t<b){g[t]=0;for(let e=t+1;e<i;e++)g[t]=L(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<n&&0!==g[t]){for(let e=t+1;e<n;e++)v[e]=0;for(let e=t+1;e<n;e++)for(let n=t+1;n<i;n++)v[e]+=g[n]*a.get(e,n);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let o=t+1;o<n;o++)a.set(o,e,a.get(o,e)+i*v[o])}}if(h)for(let e=t+1;e<i;e++)p.set(e,t,g[e])}}let S=Math.min(i,n+1);if(w<i&&(f[w]=a.get(w,w)),n<S&&(f[S-1]=0),b+1<S&&(g[b]=a.get(b,S-1)),g[S-1]=0,l){for(let t=w;t<c;t++){for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==f[t]){for(let e=t+1;e<c;e++){let i=0;for(let o=t;o<n;o++)i+=m.get(o,t)*m.get(o,e);i=-i/m.get(t,t);for(let o=t;o<n;o++)m.set(o,e,m.get(o,e)+i*m.get(o,t))}for(let e=t;e<n;e++)m.set(e,t,-m.get(e,t));m.set(t,t,1+m.get(t,t));for(let e=0;e<t-1;e++)m.set(e,t,0)}else{for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<b&&0!==g[t])for(let e=t+1;e<i;e++){let n=0;for(let o=t+1;o<i;o++)n+=p.get(o,t)*p.get(o,e);n=-n/p.get(t+1,t);for(let o=t+1;o<i;o++)p.set(o,e,p.get(o,e)+n*p.get(o,t))}for(let e=0;e<i;e++)p.set(e,t,0);p.set(t,t,1)}let T=S-1,M=0,E=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+E*Math.abs(f[t]+Math.abs(f[t+1]));if(Math.abs(g[t])<=e||Number.isNaN(g[t])){g[t]=0;break}}if(t===S-2)e=4;else{let n;for(n=S-1;n>=t&&n!==t;n--){let e=(n!==S?Math.abs(g[n]):0)+(n!==t+1?Math.abs(g[n-1]):0);if(Math.abs(f[n])<=E*e){f[n]=0;break}}n===t?e=3:n===S-1?e=1:(e=2,t=n)}switch(t++,e){case 1:{let e=g[S-2];g[S-2]=0;for(let n=S-2;n>=t;n--){let o=L(f[n],e),s=f[n]/o,r=e/o;if(f[n]=o,n!==t&&(e=-r*g[n-1],g[n-1]=s*g[n-1]),h)for(let t=0;t<i;t++)o=s*p.get(t,n)+r*p.get(t,S-1),p.set(t,S-1,-r*p.get(t,n)+s*p.get(t,S-1)),p.set(t,n,o)}break}case 2:{let e=g[t-1];g[t-1]=0;for(let i=t;i<S;i++){let o=L(f[i],e),s=f[i]/o,r=e/o;if(f[i]=o,e=-r*g[i],g[i]=s*g[i],l)for(let e=0;e<n;e++)o=s*m.get(e,i)+r*m.get(e,t-1),m.set(e,t-1,-r*m.get(e,i)+s*m.get(e,t-1)),m.set(e,i,o)}break}case 3:{const e=Math.max(Math.abs(f[S-1]),Math.abs(f[S-2]),Math.abs(g[S-2]),Math.abs(f[t]),Math.abs(g[t])),o=f[S-1]/e,s=f[S-2]/e,r=g[S-2]/e,a=f[t]/e,u=g[t]/e,c=((s+o)*(s-o)+r*r)/2,d=o*r*(o*r);let v=0;0===c&&0===d||(v=c<0?0-Math.sqrt(c*c+d):Math.sqrt(c*c+d),v=d/(c+v));let y=(a+o)*(a-o)+v,w=a*u;for(let e=t;e<S-1;e++){let o=L(y,w);0===o&&(o=Number.MIN_VALUE);let s=y/o,r=w/o;if(e!==t&&(g[e-1]=o),y=s*f[e]+r*g[e],g[e]=s*g[e]-r*f[e],w=r*f[e+1],f[e+1]=s*f[e+1],h)for(let t=0;t<i;t++)o=s*p.get(t,e)+r*p.get(t,e+1),p.set(t,e+1,-r*p.get(t,e)+s*p.get(t,e+1)),p.set(t,e,o);if(o=L(y,w),0===o&&(o=Number.MIN_VALUE),s=y/o,r=w/o,f[e]=o,y=s*g[e]+r*f[e+1],f[e+1]=-r*g[e]+s*f[e+1],w=r*g[e+1],g[e+1]=s*g[e+1],l&&e<n-1)for(let t=0;t<n;t++)o=s*m.get(t,e)+r*m.get(t,e+1),m.set(t,e+1,-r*m.get(t,e)+s*m.get(t,e+1)),m.set(t,e,o)}g[S-2]=y,M+=1;break}case 4:if(f[t]<=0&&(f[t]=f[t]<0?-f[t]:0,h))for(let e=0;e<=T;e++)p.set(e,t,-p.get(e,t));for(;t<T&&!(f[t]>=f[t+1]);){let e=f[t];if(f[t]=f[t+1],f[t+1]=e,h&&t<i-1)for(let n=0;n<i;n++)e=p.get(n,t+1),p.set(n,t+1,p.get(n,t)),p.set(n,t,e);if(l&&t<n-1)for(let i=0;i<n;i++)e=m.get(i,t+1),m.set(i,t+1,m.get(i,t)),m.set(i,t,e);t++}M=0,S--}}if(u){let t=p;p=m,m=t}this.m=n,this.n=i,this.s=f,this.U=m,this.V=p}solve(t){let e=t,n=this.threshold,i=this.s.length,o=P.zeros(i,i);for(let t=0;t<i;t++)Math.abs(this.s[t])<=n?o.set(t,t,0):o.set(t,t,1/this.s[t]);let s=this.U,r=this.rightSingularVectors,a=r.mmul(o),l=r.rows,h=s.rows,u=P.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let n=0;for(let o=0;o<i;o++)n+=a.get(t,o)*s.get(e,o);u.set(t,e,n)}return u.mmul(e)}solveForDiagonal(t){return this.solve(P.diag(t))}inverse(){let t=this.V,e=this.threshold,n=t.rows,i=t.columns,o=new P(n,this.s.length);for(let s=0;s<n;s++)for(let n=0;n<i;n++)Math.abs(this.s[n])>e&&o.set(s,n,t.get(s,n)/this.s[n]);let s=this.U,r=s.rows,a=s.columns,l=new P(n,r);for(let t=0;t<n;t++)for(let e=0;e<r;e++){let n=0;for(let i=0;i<a;i++)n+=o.get(t,i)*s.get(e,i);l.set(t,e,n)}return l}get condition(){return 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n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(s,a);s=t.subParts1,a=t.subParts2}const m=t.measureText(d(s).join("")),p=t.measureText(d(a).join("")),g=Math.max(m.width,p.width);u&&(i=g+4*s.length,t.canvas.width=g+4*s.length);let y=Math.max(e,e+(i-(g+4*s.length))/2);const w=Math.max(n,n+(o-28)/2);t.save(),t.beginPath(),t.rect(e,n,u?g+4*s.length:i,o),t.clip(),t.font="12px monospace",t.textBaseline="top";let b=c.UE.Color;"HELM"!=l&&(b=(0,r.py)(l.substring(l.length-2)));for(let e=0;e<s.length;e++){const n=s[e],r=a[e],l=b.get(n);if(n!=r){const s=b.get(r),a=h(y,w-7,i,o,t,n,l,0,!0),u=h(y,w+7,i,o,t,r,s,0,!0);y=Math.max(u,a),f&&(f[e]=v(n,r,l,s,w,7,o))}else y=h(y,w,i,o,t,n,l,0,!0,.5);y+=4}t.restore()}function v(t,e,n,i,o,s,r){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const u=l.measureText(d([t]).join("")).width,c=l.measureText(d([e]).join("")).width,f=Math.max(u,c);return a.height=r,a.width=f+4,l.font="12px 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0,(function*(){this.subs.push(ui.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.subs.push(rxjs.fromEvent(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}))}onTableAttached(){const t=Object.create(null,{onTableAttached:{get:()=>super.onTableAttached}});return __awaiter(this,void 0,void 0,(function*(){const e=t.onTableAttached.bind(this);this.viewPromise=this.viewPromise.then((()=>__awaiter(this,void 0,void 0,(function*(){e(),this.viewed||(yield this.buildView("onTableAttached"),this.viewed=!0)}))))}))}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){console.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((()=>__awaiter(this,void 0,void 0,(function*(){this.viewed&&(yield this.destroyView("setData"),this.viewed=!1)})))),this.regions=e,this.dataFrame=t,this.viewPromise=this.viewPromise.then((()=>__awaiter(this,void 0,void 0,(function*(){this.viewed||(yield this.buildView("setData"),this.viewed=!0)}))))}detach(){const t=super.detach.bind(this);this.viewPromise=this.viewPromise.then((()=>__awaiter(this,void 0,void 0,(function*(){this.viewed&&(yield this.destroyView("detach"),this.viewed=!1),t()}))))}destroyView(t){return __awaiter(this,void 0,void 0,(function*(){console.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&ui.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}))}buildView(t){return __awaiter(this,void 0,void 0,(function*(){console.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort();this.logos=[];for(let t=0;t<n.length;t++){const i={};for(const o of this.chains){const s=e.find((e=>e.order==n[t]&&e.chain==o));i[o]=yield this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:s.sequenceColumnName,startPositionName:s.positionStartName,endPositionName:s.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight})}this.logos[t]=i}this.mainLayout=ui.table(this.chains,(t=>[...n.length>0?[ui.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",ui.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=ui.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",ui.tooltip.bind(this.filterSourceInput.root,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=ui.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),console.debug("Bio: VdRegionsViewer.buildView() end")}))}calcSize(){const t=(this.root.clientHeight-54)/this.chains.length,e=Math.min(t,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));for(let t=0;t<this.logos.length;t++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[t][i].root.style.height=`${e}px`}}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?FilterSources.Selected:FilterSources.Filtered;for(let e=0;e<this.logos.length;e++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[e][i].setOptions({[wlPROPS.filterSource]:t})}}}var T=n(6098),M=n(850),E=n(7983),A=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function R(t){return A(this,void 0,void 0,(function*(){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&(yield(0,E.HV)(t.seqCol,!1)),yield i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}))}function P(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function N(t){return 1/(1+t)}function x(t){return 1/t-1}var L=n(3379),G=n.n(L),_=n(7795),I=n.n(_),W=n(569),F=n.n(W),k=n(3565),D=n.n(k),V=n(9216),H=n.n(V),O=n(4589),Y=n.n(O),U=n(9414),B={};B.styleTagTransform=Y(),B.setAttributes=D(),B.insert=F().bind(null,"head"),B.domAPI=I(),B.insertStyleElement=H(),G()(U.Z,B),U.Z&&U.Z.locals&&U.Z.locals;var Z=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};const K=new b.Subject,$=["Levenshtein"],z="act_diff",X="sali",q="sim",j="line_index",J=["1_seq","2_seq"],Q="filterCliffs";function tt(t,e){const n=s.BitSet.create(t.rowCount),i=t.col(e).getRawData();for(let t=0;t<i.length;t++)n.set(t,!!i[t],!1);return n}function et(t,e,n){const i=e.getBoundingClientRect(),o=t.clientX-i.left,s=t.clientY-i.top;let r=null,a=0;for(const t of n){const e=Math.abs(Math.hypot(t.a[0]-o,t.a[1]-s)+Math.hypot(t.b[0]-o,t.b[1]-s)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,r=t)}return r}const nt=new Uint32Array(65536);var it,ot,st,rt,at=n(3979);(rt=it||(it={})).Levenshtein="Levenshtein",rt.JaroWinkler="Jaro-Winkler",rt.Manhattan="Manhattan",function(t){t.Euclidean="Euclidean"}(ot||(ot={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean"}(st||(st={}));const lt={[ot.Euclidean]:M.dP},ht={[it.Levenshtein]:(t,e)=>{if(t.length<e.length){const n=e;e=t,t=n}return 0===e.length?t.length:t.length<=32?((t,e)=>{const n=t.length,i=e.length,o=1<<n-1;let s=-1,r=0,a=n,l=n;for(;l--;)nt[t.charCodeAt(l)]|=1<<l;for(l=0;l<i;l++){let t=nt[e.charCodeAt(l)];const n=t|r;t|=(t&s)+s^s,r|=~(t|s),s&=t,r&o&&a++,s&o&&a--,r=r<<1|1,s=s<<1|~(n|r),r&=n}for(l=n;l--;)nt[t.charCodeAt(l)]=0;return a})(t,e):((t,e)=>{const n=e.length,i=t.length,o=[],s=[],r=Math.ceil(n/32),a=Math.ceil(i/32);for(let t=0;t<r;t++)s[t]=-1,o[t]=0;let l=0;for(;l<a-1;l++){let r=0,a=-1;const h=32*l,u=Math.min(32,i)+h;for(let e=h;e<u;e++)nt[t.charCodeAt(e)]|=1<<e;for(let t=0;t<n;t++){const n=nt[e.charCodeAt(t)],i=s[t/32|0]>>>t&1,l=o[t/32|0]>>>t&1,h=n|r,u=((n|l)&a)+a^a|n|l;let c=r|~(u|a),d=a&u;c>>>31^i&&(s[t/32|0]^=1<<t),d>>>31^l&&(o[t/32|0]^=1<<t),c=c<<1|i,d=d<<1|l,a=d|~(h|c),r=c&h}for(let e=h;e<u;e++)nt[t.charCodeAt(e)]=0}let h=0,u=-1;const c=32*l,d=Math.min(32,i-c)+c;for(let e=c;e<d;e++)nt[t.charCodeAt(e)]|=1<<e;let f=i;for(let t=0;t<n;t++){const n=nt[e.charCodeAt(t)],r=s[t/32|0]>>>t&1,a=o[t/32|0]>>>t&1,l=n|h,c=((n|a)&u)+u^u|n|a;let d=h|~(c|u),m=u&c;f+=d>>>i-1&1,f-=m>>>i-1&1,d>>>31^r&&(s[t/32|0]^=1<<t),m>>>31^a&&(o[t/32|0]^=1<<t),d=d<<1|r,m=m<<1|a,u=m|~(l|d),h=d&l}for(let e=c;e<d;e++)nt[t.charCodeAt(e)]=0;return f})(t,e)},[it.JaroWinkler]:at.H$,[it.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let n=0;for(let i=1;i<t.length;i++)n+=t[i]==e[i]?0:1;return n/t.length}}},ut={[st.Tanimoto]:function(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount();if(0==n)return 1;const i=t.andWithCountBits(e,!0);return i/(n-i)}(t,e))},[st.Dice]:function(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount();return 0==n?0:2*t.andWithCountBits(e,!0)/n}(t,e))},[st.Asymmetric]:function(t,e){return x(function(t,e){const n=Math.min(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))},[st.BraunBlanquet]:function(t,e){return x(function(t,e){const n=Math.max(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))},[st.Cosine]:function(t,e){return x(function(t,e){const n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)/Math.sqrt(n)}(t,e))},[st.Kulczynski]:function(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*n/(2*i)}(t,e))},[st.McConnaughey]:function(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*n-i)/i}(t,e))},[st.RogotGoldberg]:function(t,e){return x(function(t,e){const n=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),o=t.length,s=o-i+n;return n==o||s==o?1:n/i+s/(2*o-i)}(t,e))},[st.Russel]:function(t,e){return x(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))},[st.Sokal]:function(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*n-3*i)}(t,e))},[st.Hamming]:function(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)},[st.Euclidean]:function(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}};var ct,dt;(dt=ct||(ct={})).Vector="Vector",dt.String="String",dt.BitArray="BitArray";const ft={[ct.Vector]:{[ot.Euclidean]:lt[ot.Euclidean]},[ct.String]:{[it.Levenshtein]:ht[it.Levenshtein],[it.JaroWinkler]:ht[it.JaroWinkler],[it.Manhattan]:ht[it.Manhattan]},[ct.BitArray]:{[st.Tanimoto]:ut[st.Tanimoto],[st.Dice]:ut[st.Dice],[st.Asymmetric]:ut[st.Asymmetric],[st.BraunBlanquet]:ut[st.BraunBlanquet],[st.Cosine]:ut[st.Cosine],[st.Kulczynski]:ut[st.Kulczynski],[st.McConnaughey]:ut[st.McConnaughey],[st.RogotGoldberg]:ut[st.RogotGoldberg],[st.Russel]:ut[st.Russel],[st.Sokal]:ut[st.Sokal]}};Object.keys(ft).reduce(((t,e)=>{for(const n of Object.keys(ft[e]))t[n]=e;return t}),{});var mt=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function pt(t,e,n,o,r){return mt(this,void 0,void 0,(function*(){e.version!==e.temp["last-invalidated-version"]&&(yield(0,E.HV)(e,!1));const n=s.DataFrame.create(e.length);return n.columns.addNewString(o).init((t=>e.temp["monomeric-mols"].get(t))),yield i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:n,colName:o,simArr:r})}))}function gt(t){const e=o.divH([]),n=o.divV([o.divText(t.seqCol.name),o.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.line.mols.forEach(((n,i)=>{const s=o.divText(t.activityCol.get(n).toFixed(2));s.style.display="flex",s.style.justifyContent="left",s.style.paddingLeft="30px",e.append(o.divV([o.divText(t.seqCol.get(n)),s]))})),e}function vt(t){const e=o.div();e.append(o.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2),i=new Array(2);t.line.mols.forEach(((e,o)=>{n[o]=t.seqCol.get(e),i[o]=t.activityCol.get(e)}));const a={},l=t.seqCol.getTag(s.TAGS.UNITS),h=t.seqCol.getTag("separator"),u=(0,r.vU)(l,h),c=function(t,e,n,i){const o=document.createElement("canvas"),s=o.getContext("2d");return o.height=30,g(s,0,0,0,30,t,e,n,!0,i),o}(u(n[0]),u(n[1]),l,a);return e.append(o.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(function(t){const e=o.div();if(Object.keys(t).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}(a)),e.append(yt("Activity delta",Math.abs(i[0]-i[1]))),e.append(yt("Cliff",t.sali)),e}function yt(t,e){return o.divH([o.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function wt(t,e){const n=s.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(s.TAGS.UNITS,t.col(e[0]).getTag(s.TAGS.UNITS)),n.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}n(1047),n(4004),n(7228),n(7767);var bt=n(5226);n(9133);class Ct extends s.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[DG.TAGS.UNITS,"aligned","separator","alphabet"],this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",CHEM_SIMILARITY_METRICS[0],{choices:CHEM_SIMILARITY_METRICS}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}onTableAttached(){return sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){if(this.init(),this.dataFrame){this.subs.push(DG.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render()})))));const t="diversity"!==this.name;this.subs.push(DG.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(t)}))))),this.subs.push(DG.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.subs.push(DG.debounce(ui.onSizeChanged(this.root),50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.moleculeColumn=this.dataFrame.columns.bySemType(DG.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=(this.moleculeColumn,void 0),this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}yield this.render()}))}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===DG.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){return sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){}))}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==DG.SEMTYPE.MACROMOLECULE&&(grok.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}n(7241);var St=n(4293);n(9943),n(4413);var Tt,Mt=n(1061),Et=n(8341),At=n(499),Rt=(n(1345),n(4221),n(7659),n(3659),n(4588));class Pt{constructor(t){var e,n,i,o,s,r,a;this.steps=null!==(e=null==t?void 0:t.steps)&&void 0!==e?e:0,this.cycles=null!==(n=null==t?void 0:t.cycles)&&void 0!==n?n:1e6,this.cutoff=null!==(i=null==t?void 0:t.cutoff)&&void 0!==i?i:0,this.lambda=null!==(o=null==t?void 0:t.lambda)&&void 0!==o?o:2,this.dlambda=null!==(s=null==t?void 0:t.dlambda)&&void 0!==s?s:.01,this.lambda2=this.lambda/2,this.dlambda2=this.dlambda/2,this.epsilon=null!==(r=null==t?void 0:t.epsilon)&&void 0!==r?r:1e-10,this.distanceFunction=null!==(a=null==t?void 0:t.distance)&&void 0!==a?a:M.dP,this.distance=[]}initDistance(t){this.distance=(0,M.H3)(t,this.distanceFunction)}calcDistance(t,e,n){return this.distance[e][n]}embed(t){const e=t.length,n=(0,M.kO)(e,Pt.dimension,40);let i=this.lambda2;0==this.steps&&(this.steps=t.length-1),this.initDistance(t);for(let o=0;o<this.cycles;++o){for(let o=0;o<this.steps;++o){const o=(0,Rt.I)(e);let s=(0,Rt.I)(e);for(;o==s;)s=(0,Rt.I)(e);const r=n[o],a=n[s],l=this.calcDistance(t,o,s),h=(0,M.dP)(r,a);if(0==this.cutoff||l<=this.cutoff||h<l){const t=i*(l-h)/(h+this.epsilon),e=(0,M.On)(r,a,-1);n[o]=(0,M.On)(r,e,t),n[s]=(0,M.On)(a,e,-t)}}if(i-=this.dlambda2,i<=0)break}return n}}Pt.dimension=2;class Nt{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const n=t,i=Nt._createBuffer(n);if(e)for(let t=0;t<i.length;t++)i[t]=-1;this._data=i,this._length=n}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,n,i){if(t<e||t>n)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${n})`)}copy(t,e,n){for(let i=0;i<n;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const n=new Nt(t._length);n._length=t._length,n._data=Nt._createBuffer(n._length),n._version=0;const i=t.lengthInInts;for(let o=0;o<i;o++)n._data[o]=t._data[o]&e._data[o];return n}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new Nt(t.length);e._version=0;for(let n=0;n<e._length;n++)t[n]&&(e._data[Math.floor(n/32)]|=1<<(n%32&31));return e}static fromSeq(t,e){const n=new Nt(t);for(let i=0;i<t;++i)n.setBit(i,e(i));return n._version=0,n}static fromString(t){return Nt.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const n=new Nt(t);return n._data=e,n}static fromBytes(t){const e=t.length,n=new Nt(8*e);n._data=new Uint32Array(Math.floor((e+3)/4)),n._length=8*e;let i=0,o=0;for(;e-o>=4;)n._data[i++]=255&t[o]|(255&t[o+1])<<8|(255&t[o+2])<<16|(255&t[o+3])<<24,o+=4;return e-o==3&&(n._data[i]=(255&t[o+2])<<16),e-o==2&&(n._data[i]|=(255&t[o+1])<<8),e-o==1&&(n._data[i]|=255&t[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new Nt(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,i=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,i=!0,o=!0){if(n&&o&&this.setAll(!e,!1),o)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return Nt.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return n}setRange(t,e,n,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const o=Math.min(t,e),s=Math.max(t,e);if(n)for(let t=o;t<=s;t++)this.setTrue(t);else for(let t=o;t<=s;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,n=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const i=this._length;this.setLength(this._length+e);for(let n=i-1;n>=t;n--)this.setBit(n+e,this.getBit(n));for(let i=t;i<t+e;i++)this.setBit(i,n)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let n=t;n<this._length-e;n++)this.setBit(n,this.getBit(n+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let n=0;for(let i=-1;-1!=(i=t.findNext(i,!e));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(t){return 0!=(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,n=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=Nt._onBitCount[255&t];let n=this._data[e];const i=31&this._length;for(0!=i&&(n&=~(4294967295<<i));0!=n;n>>>=8)this._selectedCount+=Nt._onBitCount[255&n];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)e+=t(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)e+=t(n)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let n=0;const i=this.lengthInInts;let o=0;for(;o<i-1;o++)for(let e=this._data[o]&t._data[o];0!=e;e>>>=8)n+=Nt._onBitCount[255&e];let s=this._data[o]&t._data[o];const r=31&this._length;for(0!=r&&(s&=~(4294967295<<r));0!=s;s>>>=8)n+=Nt._onBitCount[255&s];return e?n:this._length-n}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let n=31&(t=t<0?0:t+1);const i=this.lengthInInts;for(let o=Math.floor(t/32);o<i;o++){let i=e?this._data[o]:~this._data[o];if(0!=n)i&=4294967295<<n&4294967295,n=0;else if(!e&&-4294967296==i)continue;for(let e=0;0!=i;e+=8,i>>>=8){const n=Nt._firstOnBit[255&i];if(n>=0)return(t=n+32*o+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let n=1+(t=t<0?this._length-1:t-1)&31;for(let i=Math.floor(t/32);i>=0;i--){let t=e?this._data[i]:~this._data[i];0!=n&&(t&=~(4294967295<<n),n=0);for(let e=24;0!=t;e-=8,t<<=8){const n=Nt._lastOnBit[t>>>24];if(n>=0)return n+32*i+e}}return-1}}Nt._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),Nt._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),Nt._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7]),s.SEMTYPE.MOLECULE,s.SEMTYPE.MACROMOLECULE,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Tt||(Tt={})),n(3336);var 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l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};const L="input.fa",G="result.fasta";function _(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}function I(t,e=!1,n="",s=null){var r,a;return x(this,void 0,void 0,(function*(){let l=t.toList();e&&(l=l.map((t=>N.clean(t).replace(/\-/g,""))));const h=t.length;null!=s||(s=i.Column.string("Clusters",h).init("0")),s.type!=i.COLUMN_TYPE.STRING&&(s=s.convertTo(i.TYPE.STRING)),s.compact();const u=s.categories,c=s.getRawData(),d=new Array(u.length),f=new Array(u.length);for(let t=0;t<h;++t){const e=c[t];(null!==(r=d[e])&&void 0!==r?r:d[e]=[]).push(l[t]),(null!==(a=f[e])&&void 0!==a?a:f[e]=[]).push(t)}const m=yield new A(["base/1.0.0",{tool:"kalign",version:"3.3.1",reinit:!0}]),p=i.Column.string(n,h);for(let t=0;t<u.length;++t){const e=_(d[t]);console.log(["fasta.length =",e.length]),yield m.fs.writeFile(L,e);const n=yield m.exec(`kalign ${L} -f fasta -o ${G}`);console.warn(n);const i=yield m.cat(G);if(!i)throw new Error("kalign output no result");const s=new o.i(i).sequencesArray,r=f[t];for(let t=0;t<s.length;++t)p.set(r[t],s[t])}const g=t.getTag(i.TAGS.UNITS),v=t.getTag("aligned")+".MSA",y=t.getTag("alphabet");return p.setTag(i.TAGS.UNITS,g),p.setTag("aligned",v),p.setTag("alphabet",y),p.semType=i.SEMTYPE.MACROMOLECULE,p}))}},8341:(t,e,n)=>{"use strict";n.d(e,{J:()=>a,f:()=>h});var i=n(4469),o=n(976),s=n(3553),r=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];function h(t,e,n="ginsi",a=1.53,h=0,c=null){var d;return r(this,void 0,void 0,(function*(){const r=t.length;null!=c||(c=o.Column.int("Clusters",r).init(0)),c.type!=o.COLUMN_TYPE.STRING&&(c=c.convertTo(o.TYPE.STRING));const f=c.categories,m=new Array(f.length);for(let e=0;e<r;++e){const n=c.get(e);if(""===n)continue;const i=f.indexOf(n),o=t.get(e);o&&(null!==(d=m[i])&&void 0!==d?d:m[i]=[]).push({ID:e.toString(),HELM:o})}const p=yield(void 0!==i.dapi.docker?i.dapi.docker.dockerContainers:i.dapi.dockerfiles).filter("bio").first(),g=new Array(r);for(const t of m){const e=(yield u(p.id,t,n,a,h)).Alignment;for(const t of e)g[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(s.rs.SEPARATOR)}const v=o.Column.fromStrings(e,g);return v.setTag(o.TAGS.UNITS,"separator"),v.setTag("separator",s.rs.SEPARATOR),v.setTag("aligned","SEQ.MSA"),v.setTag("alphabet","UN"),v.setTag(".alphabetIsMultichar","true"),v.semType=o.SEMTYPE.MACROMOLECULE,v}))}function u(t,e,n,o,s){return r(this,void 0,void 0,(function*(){const r={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${n}&gap_open=${o}&gap_extend=${s}`,l=yield(void 0!==i.dapi.docker?i.dapi.docker.dockerContainers:i.dapi.dockerfiles).request(t,a,r);return JSON.parse(null!=l?l:"{}")}))}},9943:(t,e,n)=>{"use strict";n.d(e,{i$:()=>s,sK:()=>r}),n(976),n(3870),n(4469),n(6414);var i=n(6714);n(499);const o=60;function s(t,e,n=o,s="\n"){const a=i.kB,l=[];for(let i=0;i<e.length;i++){const o=t.map((t=>t.get(i).toString())).join("|"),h=r(e.get(i),a,n);l.push(`>${o}${s}`);for(const t of h)l.push(`${t}${s}`)}return"".concat(...l)}function r(t,e,n=o){const i=e(t);let s=0;const r=i.length,a=[];for(;s<r;){const t=i.slice(s,s+n),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");a.push(e),s+=t.length}return a}},4293:(t,e,n)=>{"use strict";n.d(e,{Y:()=>r,m:()=>s});var i=n(4469),o=n(976);function s(){const t=i.shell.t.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null!==t)return t;i.shell.error("Current table does not contain macromolecules")}function r(t,e){t.innerHTML="",t.append(e)}},2433:(t,e,n)=>{"use strict";n.d(e,{CK:()=>b,eZ:()=>S,yW:()=>w});var i,o,s,r,a,l,h=n(4469),u=n(3870),c=n(976),d=n(6414),f=n.n(d),m=n(701),p=n(499),g=n(6714),v=n(9298),y=n(7604);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new c.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},c.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class w{constructor(t=0,e=new c.Rect(0,0,0,0)){this.count=t,this.bounds=e}}class b{constructor(t,e,n={},i=0,o=0){this.pos=t,this.name=e,this.freq=n,this.rowCount=i,this.sumForHeightCalc=o}}!function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(i||(i={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(s||(s={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(r||(r={})),function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(a||(a={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(l||(l={}));class C extends c.JsViewer{get filter(){let t;switch(this.filterSource){case r.Filtered:t=this.dataFrame.filter;break;case r.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){var t;return"auto"===this.positionMarginState&&!0===(null===(t=this.unitsHandler)||void 0===t?void 0:t.getAlphabetIsMultichar())||"enable"===this.positionMarginState?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.splitter=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=C.viewerCount,C.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(l.sequenceColumnName,null,{category:a.DATA}),this.startPositionName=this.string(l.startPositionName,null,{category:a.DATA}),this.endPositionName=this.string(l.endPositionName,null,{category:a.DATA}),this.skipEmptySequences=this.bool(l.skipEmptySequences,!0,{category:a.DATA}),this.skipEmptyPositions=this.bool(l.skipEmptyPositions,!1,{category:a.DATA}),this.shrinkEmptyTail=this.bool(l.shrinkEmptyTail,!0,{category:a.DATA}),this.backgroundColor=this.int(l.backgroundColor,4294967295,{category:a.STYLE}),this.positionHeight=this.string(l.positionHeight,v.ES.full,{category:a.STYLE,choices:Object.values(v.ES)}),this._positionWidth=this.positionWidth=this.float(l.positionWidth,16,{category:a.STYLE}),this.verticalAlignment=this.string(l.verticalAlignment,i.MIDDLE,{category:a.LAYOUT,choices:Object.values(i)}),this.horizontalAlignment=this.string(l.horizontalAlignment,o.CENTER,{category:a.LAYOUT,choices:Object.values(o)}),this.fixWidth=this.bool(l.fixWidth,!1,{category:a.LAYOUT}),this.fitArea=this.bool(l.fitArea,!0,{category:a.LAYOUT}),this.minHeight=this.float(l.minHeight,50,{category:a.LAYOUT}),this.maxHeight=this.float(l.maxHeight,100,{category:a.LAYOUT}),this.positionMarginState=this.string(l.positionMarginState,s.AUTO,{category:a.LAYOUT,choices:Object.values(s)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(l.positionMargin,t,{category:a.LAYOUT,min:0,max:16}),this.filterSource=this.string(l.filterSource,r.Filtered,{category:a.BEHAVIOR,choices:Object.values(r)}),this.slider=u.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=u.canvas(),this.canvas.style.width="100%"}init(){this.initialized?console.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=u.div("No message"),this.msgHost.style.display="none",this.canvas=u.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=u.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(m.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(m.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(m.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(u.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame)if(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,g.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol){const t=this.seqCol.getTag(c.TAGS.UNITS),e=this.seqCol.getTag("separator");this.splitter=(0,g.vU)(t,e),this.unitsHandler=new p.C(this.seqCol),this.updatePositions(),this.cp=(0,g.dQ)(this.seqCol)}else this.splitter=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null;this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...t.map((t=>null!==t?this.splitter(t).length:0))):0,n=this.seqCol.getTag(v.DX.positionNames);this.positionNames=n?n.split(v.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),n=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,n=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,n)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case l.sequenceColumnName:case l.startPositionName:case l.endPositionName:case l.filterSource:this.updateSeqCol();break;case l.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case l.fixWidth:case l.fitArea:case l.positionMargin:this.updateSlider();break;case l.shrinkEmptyTail:case l.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){super.onTableAttached();const t=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),this.updateSeqCol(),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}detach(){const t=Object.create(null,{detach:{get:()=>super.detach}});return e=this,n=void 0,o=function*(){const e=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${e} ) start`),t.detach.call(this),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)},new((i=void 0)||(i=Promise))((function(t,s){function r(t){try{l(o.next(t))}catch(t){s(t)}}function a(t){try{l(o.throw(t))}catch(t){s(t)}}function l(e){var n;e.done?t(e.value):(n=e.value,n instanceof i?n:new i((function(t){t(n)}))).then(r,a)}l((o=o.apply(e,n||[])).next())}));var e,n,i,o}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,n=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),i=this.positions[n];if(null==i)return[n,null,null];const o=Object.keys(i.freq).find((n=>i.freq[n].bounds.contains(e,t.y)));return void 0===o?[n,null,null]:[n,o,i.freq[o]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const n=t.length;let i=0;for(let o=0;o<n;o++)e(t[o])||(t[i]=t[o],i++);return t.length=i,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>{var e;return(null===(e=null==t?void 0:t.freq["-"])||void 0===e?void 0:e.count)===t.rowCount}))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=new p.C(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new b(this.startPosition+t,e)}const n=this.filter.getSelectedIndexes();this.rowsMasked=n.length,this.rowsNull=0;for(const t of n){let e=this.seqCol.get(t);e||(e=this._nullSequence(),++this.rowsNull);const n=this.splitter(e);for(let t=0;t<this.Length;t++){const e=this.positions[t].freq,i=n[this.startPosition+t]||"-";i in e||(e[i]=new w),e[i].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==v.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const n=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-n*Math.log2(n)}}}this._removeEmptyPositions();const i=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const n=this.positions[e].freq,o=this.positions[e].rowCount,s=this.getAlphabetSize();this.positionHeight==v.ES.Entropy&&null==s&&h.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(s),a=this.positionHeight==v.ES.Entropy?i*(r-this.positions[e].sumForHeightCalc)/r:i;let l=this.axisHeight*t+(i-a-1);const u=Object.entries(n).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of u){const n=t[1],i=a*n.count/o;n.bounds=new c.Rect(e*this.positionWidthWithMargin,l,this._positionWidth,i),l+=i}}}render(t=!0){var e;if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const n=this.canvas.getContext("2d");if(!n)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio;t&&this._calculate(i),n.resetTransform(),n.fillStyle=c.Color.toHtml(this.backgroundColor),n.fillRect(0,0,this.canvas.width,this.canvas.height),n.textBaseline=this.textBaseline;const o=this.countOfRenderPositions+1,s=this.visibleSlider?Math.floor(this.slider.min):0,r=Math.min(this.Length,s+o),a=10*i;n.resetTransform(),n.fillStyle="black",n.textAlign="center",n.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>n.measureText(t.name).width))),h=l<this._positionWidth-2?1:(this._positionWidth-2)/l;for(let t=this.firstVisibleIndex;t<r;t++){const e=this.positions[t];n.resetTransform(),n.setTransform(h,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*s,0),n.fillText(e.name,0,0)}for(let t=this.firstVisibleIndex;t<r;t++)for(const[i,o]of Object.entries(this.positions[t].freq))if("-"!==i){const t=(0,g.GU)(i,5),s=o.bounds,r=s.left-this.positionWidthWithMargin*this.firstVisibleIndex;n.resetTransform(),n.strokeStyle="lightgray",n.lineWidth=1,n.rect(r,s.top,s.width,s.height),n.fillStyle=null!==(e=this.cp.get(i))&&void 0!==e?e:this.cp.get("other"),n.textAlign="left",n.font="16px Roboto, Roboto Local, sans-serif";const a=n.measureText(t);n.setTransform(s.width/a.width,0,0,s.height/12.2,r,s.top),n.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,n=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,n*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${n}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let o=0;switch(this.verticalAlignment){case"top":o=0;break;case"middle":o=Math.max(0,(this.root.clientHeight-n)/2);break;case"bottom":o=Math.max(0,this.root.clientHeight-n-t)}let s=0;switch(this.horizontalAlignment){case"left":s=0;break;case"center":s=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":s=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${o}px`,"important"),this.host.style.setProperty("margin-left",`${s}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${o+i}px`,"important"),this.root.clientHeight<=n?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){var t,e;return null!==(e=null===(t=this.unitsHandler)||void 0===t?void 0:t.getAlphabetSize())&&void 0!==e?e:0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=(0,y.O)(t);console.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=(0,y.O)(t);console.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=(0,y.O)(t);console.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,n=window.devicePixelRatio,i=this.canvas.getCursorPosition(e,n),[o,s]=this.getMonomer(i);if(this.dataFrame&&this.seqCol&&this.splitter&&s){const t=this.positions[o],n=S(this.dataFrame,this.seqCol,this.filter,this.splitter,s,t),i=u.div([u.div(`${s}`),u.div(`${n} rows`)]);u.tooltip.show(i,e.x+16,e.y+16)}else u.tooltip.hide()}catch(t){const e=(0,y.O)(t);console.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(e,n));if(this.dataFrame&&this.seqCol&&this.splitter&&o){const t=this.positions[i],e=c.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,n,i,o,s,r){if(!n.getSelectedIndexes().includes(i))return!1;const a=e.get(i),l=a?o(a)[r.pos]:null;return l===s||""===l&&"-"===s}(this.dataFrame,this.seqCol,this.filter,e,this.splitter,o,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=(0,y.O)(t);console.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const 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v(this.column.getTag("separator")):new y,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),null===(r=this.onBioFilterChangedSubs)||void 0===r||r.unsubscribe();let a=this.bioFilter.onChanged;a=a.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=a.subscribe((t=>f(this,void 0,void 0,(function*(){return yield this._onInputChanged()}))))}detach(){super.detach()}applyFilter(){var t;this.bitset&&!this.isDetached&&(null===(t=this.dataFrame)||void 0===t||t.filter.and(this.bitset))}saveState(){var t;const e=super.saveState();return e.bioSubstructure=null===(t=this.bioFilter)||void 0===t?void 0:t.substructure,e}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}_onInputChanged(){var t,e,n;return f(this,void 0,void 0,(function*(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=yield null===(e=this.bioFilter)||void 0===e?void 0:e.substrucrureSearch(this.column),this.calculating=!1,null===(n=this.dataFrame)||void 0===n||n.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,null===(t=this.dataFrame)||void 0===t||t.rows.requestFilter()}))}}class p{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return null}))}}class g extends p{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return yield(0,l.pf)(this.substructure,t)}))}}class v extends g{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return yield(0,l.pf)(this.substructure,t,this.colSeparator)}))}}class y extends p{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}init(){return f(this,void 0,void 0,(function*(){this.helmEditor=yield s.functions.call("HELM:helmWebEditor"),yield 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e=[],n="meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr".repeat(Math.pow(10,5));return e.push(t.Column.fromList("string","MSA",new Array(Math.pow(10,2)).fill(n))),e.push(t.Column.fromList("string","Activity",new Array(Math.pow(10,2)).fill("7.30751"))),e}function G(e,n){const i=e(),o=t.DataFrame.fromColumns(i),s=Date.now();var r;(r=o.columns.byName("MSA")).semType=t.SEMTYPE.MACROMOLECULE,r.setTag(t.TAGS.UNITS,"separator"),r.setTag("aligned","SEQ.MSA"),r.setTag("alphabet","UN"),r.setTag("separator","/"),h.shell.addTableView(o);const a=Date.now()-s;console.log(`Performance test: ${n}: ${a}ms`)}var _=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};(0,e.W3)("renderers",(()=>{let n,i;(0,e.bb)((()=>_(void 0,void 0,void 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o(e){return W(this,void 0,void 0,(function*(){const n=i[e],o=t.DataFrame.fromCsv(n);return yield h.data.detectSemanticTypes(o),o}))}function s(t,n=null){if("separator"===t&&!n)throw new Error(`Argument 'separator' is missed for notation '${t.toString()}'.`);return function(i){const o=new I.L(i).convert(t,n);return(0,e.l_)(o.getTag("units"),t),o}}function r(t,n,i){return W(this,void 0,void 0,(function*(){const s=(yield o(t)).getCol("seq"),r=n(s),a=(yield o(i)).getCol("seq");(0,e.f6)(r.toList(),a.toList()),new c.C(r)}))}(0,e.Bu)("testFastaPtToSeparator",(()=>W(void 0,void 0,void 0,(function*(){yield r(n.fastaPt,s("separator","-"),n.separatorPt)})))),(0,e.Bu)("testFastaDnaToSeparator",(()=>W(void 0,void 0,void 0,(function*(){yield r(n.fastaDna,s("separator","/"),n.separatorDna)})))),(0,e.Bu)("testFastaRnaToSeparator",(()=>W(void 0,void 0,void 0,(function*(){yield r(n.fastaRna,s("separator","*"),n.separatorRna)})))),(0,e.Bu)("testFastaGapsToSeparator",(()=>W(void 0,void 0,void 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e=i.Color.fromHtml(t),n=i.Color.g(e),o=i.Color.r(e),s=i.Color.b(e),r=Math.sqrt(Math.pow(0-o,2)+Math.pow(0-n,2)+Math.pow(0-s,2));return r>210?`rgb(${o/r*210},${n/r*210},${s/r*210})`:i.Color.toRgb(e)}(l.palette[e])}}l.palette=l.buildPalette();class h extends o.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},1047:(t,e,n)=>{"use strict";n.d(e,{At:()=>i,K4:()=>o});const i="MonomerName",o={monomerType:null,smiles:null,name:"MonomerName",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerCode"}},5226:(t,e,n)=>{"use strict";n.d(e,{i:()=>s});var i=n(976),o=n(499);class s{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,o.C.setUnitsToFastaColumn(e),[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6714:(t,e,n)=>{"use strict";n.d(e,{GU:()=>C,KX:()=>T,Mj:()=>w,dQ:()=>E,fy:()=>d,gM:()=>S,gP:()=>v,kB:()=>m,py:()=>A,up:()=>R,vU:()=>y,w4:()=>M});var i=n(976),o=n(6414),s=n.n(o),r=n(3659),a=n(850),l=n(2012),h=n(6137),u=n(7331),c=n(499);function d(t,e,n){const i={};let o=!0,s=null;for(const r of t.categories){const t=n(r);if(null==s?s=t.length:t.length!==s&&(o=!1),t.length>=e)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:o}}const f=/\[(\w+)\]|(\w)|(-)/g;function m(t){return s()(t.toString().matchAll(f)).map((t=>{let e;const n=t[0];return e=n.length>1?t[1]:n,e})).toArray()}const p=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,g=/\[([^\[\]]+)]/g;function v(t){p.lastIndex=0;const e=p.exec(t.toString()),n=e?e[2]:null;return(n?n.split("."):[]).map((t=>{g.lastIndex=0;const e=g.exec(t);return e&&e.length>=2?e[1]:t}))}function y(t,e,n=undefined){if(t.toLowerCase().startsWith("fasta"))return m;if(t.toLowerCase().startsWith("separator"))return function(t,e=undefined){return n=>n.split(t,e)}(e,n);if(t.toLowerCase().startsWith("helm"))return v;throw new Error(`Unexpected units ${t} .`)}function w(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`Get splitter for semType "${i.SEMTYPE.MACROMOLECULE}" only.`);return y(t.getTag(i.TAGS.UNITS),t.getTag("separator"))}const b=/(\w+)/g;function C(t,e){var n,i;const o=t.match(b),s=t.length>e||(null!==(n=null==o?void 0:o.length)&&void 0!==n?n:0)>1,r=null!==(i=null==o?void 0:o[0])&&void 0!==i?i:" ";return s?r.substring(0,e)+"…":r}function S(t){switch(t){case"DNA":return c.C.DnaFastaAlphabet;case"RNA":return c.C.RnaFastaAlphabet;case"PT":return c.C.PeptideFastaAlphabet;default:throw new Error(`Unsupported alphabet '${t}'.`)}}function T(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const o=[],s=[];for(const n of i)o.push(n in t?t[n]:0),s.push(e.has(n)?1:0);const l=new r.OW(o),h=new r.OW(s);return(0,a.MA)(l,h)/((0,a.$G)(l)*(0,a.$G)(h))}function M(t){const e=[["PT",c.C.PeptideFastaAlphabet],["DNA",c.C.DnaFastaAlphabet],["RNA",c.C.RnaFastaAlphabet]],n=e.map((e=>T(t.freq,e[1]))),i=Math.max(...n);return i>.65?e[n.indexOf(i)][0]:"UN"}function E(t,e=5){let n;return n=t.semType==i.SEMTYPE.MACROMOLECULE?new c.C(t).alphabet:M(d(t,e,m)),A(n)}function A(t){switch(t){case"PT":return l.f.GrokGroups;case"NT":case"DNA":case"RNA":return h.J.Chromatogram;default:return u.UE.Color}}function R(t){var e;const n=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let o=null!==(e=n.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")})))&&void 0!==e?e:null;return!o&&n.length>0&&(o=n[0]),o}},7767:(t,e,n)=>{"use strict";n.d(e,{L:()=>r});var i=n(976),o=n(499),s=n(6714);class r extends o.C{get splitter(){return null===this._splitter&&(this._splitter=(0,s.Mj)(this.column)),this._splitter}toFasta(t){return"fasta"===t}toSeparator(t){return"separator"===t}toHelm(t){return"helm"===t}convertFastaToSeparator(t,e=null){null===e&&(e=this.defaultGapSymbol);const n=this.getNewColumn("separator");return n.init((n=>{const i=this.column.get(n),s=this.splitter(i);for(let t=0;t<s.length;t++)s[t]===e&&(s[t]=o.C._defaultGapSymbolsDict.SEPARATOR);return s.join(t)})),n.setTag(i.TAGS.UNITS,"separator"),n.setTag("separator",t),n}getHelmWrappers(){const t=this.isDna()?"DNA1{":this.isRna()?"RNA1{":this.isPeptide()?"PEPTIDE1{":"Unknown";if("Unknown"===t)throw new Error("Neither peptide, nor nucleotide");return[t,this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$"]}convertToHelmHelper(t,e,n,i,s,r){return`${n}${this.splitter(t).map((t=>t===e?o.C._defaultGapSymbolsDict.HELM:`${i}${t}${s}`)).join(".")}${r}`}convertStringToHelm(t,e=null){null===e&&(e=this.defaultGapSymbol);const[n,i,o,s]=this.getHelmWrappers();return this.convertToHelmHelper(t,e,n,i,o,s)}convertToHelm(t=null){null===t&&(t=this.defaultGapSymbol);const[e,n,o,s]=this.getHelmWrappers(),r=this.getNewColumn("helm");return r.init((i=>{const r=this.column.get(i);return this.convertToHelmHelper(r,t,e,n,o,s)})),r.setTag(i.TAGS.UNITS,"helm"),r}convertSeparatorToFasta(t=null){null===t&&(t=o.C._defaultGapSymbolsDict.FASTA);const e=this.getNewColumn("fasta");return e.init((e=>{const n=this.column.get(e),i=this.splitter(n),o=[];for(let e=0;e<i.length;e++){const n=i[e];if(0===n.length)o.push(t);else if(n.length>1){const t="["+n+"]";o.push(t)}else o.push(n)}return o.join("")})),e.setTag(i.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?o.C._defaultGapSymbolsDict.FASTA:o.C._defaultGapSymbolsDict.SEPARATOR),n||(n=this.toFasta(e)?"":this.separator);const s=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let n=a[t];if(r&&(n=n.replace(s,"")),n===o.C._defaultGapSymbolsDict.HELM)l.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";l.push(t)}else l.push(n)}return l.join(n)}convertHelm(t,e,n){const i=this.getNewColumn(t);i.init((i=>{const o=this.column.get(i);return this.convertHelmToFastaSeparator(o,t,e,n)}));const o=(0,s.Mj)(i),r=(0,s.fy)(i,5,o).sameLength?"SEQ.MSA":"SEQ";return i.setTag("aligned",r),i}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,n)=>{"use strict";n.d(e,{C:()=>s});var i=n(976),o=n(6714);class s{static setUnitsToFastaColumn(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error("Fasta column must be MACROMOLECULE");const e=(0,o.fy)(t,5,o.kB),n=e.sameLength?"SEQ.MSA":"SEQ",s=(0,o.w4)(e);t.setTag(i.TAGS.UNITS,"fasta"),t.setTag("aligned",n),t.setTag("alphabet",s)}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){var t;const e=null!==(t=this.column.getTag("separator"))&&void 0!==t?t:void 0;if("separator"===this.notation&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=(0,o.Mj)(this.column),n=(0,o.fy)(this.column,1,t);e=Object.keys(n.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return("helm"==this.notation||"UN"==this.alphabet)&&"true"==this.column.getTag(".alphabetIsMultichar")}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t){const e=this.column,n=e.length,o=t.toLowerCase()+"("+e.name+")",s=e.dataFrame.columns.getUnusedName(o),r=i.Column.fromList("string",s,new Array(n).fill(""));r.semType=i.SEMTYPE.MACROMOLECULE,r.setTag(i.TAGS.UNITS,t),r.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const a=e.getTag("aligned");a&&r.setTag("aligned",a);const l=e.getTag("alphabet");l&&r.setTag("alphabet",l);let h=e.getTag(".alphabetSize");h&&r.setTag(".alphabetSize",h);const u=e.getTag(".alphabetIsMultichar");return void 0!==u&&r.setTag(".alphabetIsMultichar",u),"helm"==t&&(h=this.getAlphabetSize().toString(),r.setTag(".alphabetSize",h)),r}static getNewColumn(t){const e=new s(t),n=e.notation;return e.getNewColumn(n)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!s.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const o=i.Column.fromList("string",e,new Array(t).fill(""));return o.semType=i.SEMTYPE.MACROMOLECULE,o.setTag(i.TAGS.UNITS,n),o}constructor(t){this._column=t;const e=this._column.tags[i.TAGS.UNITS];if(null===e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?s._defaultGapSymbolsDict.FASTA:this.isHelm()?s._defaultGapSymbolsDict.HELM:s._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")&&(this.isFasta()||this.isSeparator()))throw new Error(`For column '${this.column.name}' of notation '${this.notation}' tag 'aligned' is mandatory.`);if(!this.column.tags.has(".alphabetIsMultichar")){if(this.isHelm())throw new Error(`For column '${this.column.name}' of notation '${this.notation}' tag '.alphabetIsMultichar' is mandatory.`);if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}}}s._defaultGapSymbolsDict={HELM:"*",SEPARATOR:"",FASTA:"-"},s.PeptideFastaAlphabet=new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),s.DnaFastaAlphabet=new Set(["A","C","G","T"]),s.RnaFastaAlphabet=new Set(["A","C","G","U"])},9298:(t,e,n)=>{"use strict";var i,o,s,r,a;n.d(e,{CI:()=>h,Ct:()=>a,DX:()=>u,ES:()=>i,dE:()=>r,iD:()=>s,vS:()=>l,vw:()=>o}),function(t){t.Entropy="Entropy",t.full="100%"}(i||(i={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(o||(o={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(s||(s={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(r||(r={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(a||(a={}));const l=new 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n}minRow(t){if(y(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n));return e}minRowIndex(t){y(this,t),E(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),n[1]=i);return n}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t));return e}maxColumnIndex(t){w(this,t),E(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),n[0]=i);return n}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t));return e}minColumnIndex(t){w(this,t),E(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),n[0]=i);return n}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let n=0;n<t;n++)e.push(this.get(n,n));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let n=0;n<this.columns;n++)e+=this.get(t,n)*this.get(t,n);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t+=this.get(e,n),this.set(e,n,t);return this}dot(t){A.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}mmul(t){t=P.checkMatrix(t);let e=this.rows,n=this.columns,i=t.columns,o=new P(e,i),s=new Float64Array(n);for(let r=0;r<i;r++){for(let e=0;e<n;e++)s[e]=t.get(e,r);for(let t=0;t<e;t++){let e=0;for(let i=0;i<n;i++)e+=this.get(t,i)*s[i];o.set(t,r,e)}}return o}strassen2x2(t){t=P.checkMatrix(t);let e=new P(2,2);const n=this.get(0,0),i=t.get(0,0),o=this.get(0,1),s=t.get(0,1),r=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),u=(n+l)*(i+h),c=(r+l)*i,d=n*(s-h),f=l*(a-i),m=(n+o)*h,p=u+f-m+(o-l)*(a+h),g=d+m,v=c+f,y=u-c+d+(r-n)*(i+s);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,v),e.set(1,1,y),e}strassen3x3(t){t=P.checkMatrix(t);let e=new P(3,3);const n=this.get(0,0),i=this.get(0,1),o=this.get(0,2),s=this.get(1,0),r=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),u=this.get(2,2),c=t.get(0,0),d=t.get(0,1),f=t.get(0,2),m=t.get(1,0),p=t.get(1,1),g=t.get(1,2),v=t.get(2,0),y=t.get(2,1),w=t.get(2,2),b=(n-s)*(-d+p),C=(-n+s+r)*(c-d+p),S=(s+r)*(-c+d),T=n*c,M=(-n+l+h)*(c-f+g),E=(-n+l)*(f-g),A=(l+h)*(-c+f),R=(-o+h+u)*(p+v-y),N=(o-u)*(p-y),x=o*v,L=(h+u)*(-v+y),G=(-o+r+a)*(g+v-w),_=(o-a)*(g-w),I=(r+a)*(-v+w),W=T+x+i*m,F=(n+i+o-s-r-h-u)*p+C+S+T+R+x+L,k=T+M+A+(n+i+o-r-a-l-h)*g+x+G+I,D=b+r*(-c+d+m-p-g-v+w)+C+T+x+G+_,H=b+C+S+T+a*y,V=x+G+_+I+s*f,O=T+M+E+h*(-c+f+m-p-g-v+y)+R+N+x,Y=R+N+x+L+l*d,U=T+M+E+A+u*w;return e.set(0,0,W),e.set(0,1,F),e.set(0,2,k),e.set(1,0,D),e.set(1,1,H),e.set(1,2,V),e.set(2,0,O),e.set(2,1,Y),e.set(2,2,U),e}mmulStrassen(t){t=P.checkMatrix(t);let e=this.clone(),n=e.rows,i=e.columns,o=t.rows,s=t.columns;function r(t,e,n){let i=t.rows,o=t.columns;if(i===e&&o===n)return t;{let i=A.zeros(e,n);return i=i.setSubMatrix(t,0,0),i}}i!==o&&console.warn(`Multiplying ${n} x ${i} and ${o} x ${s} matrix: dimensions do not match.`);let a=Math.max(n,o),l=Math.max(i,s);return e=r(e,a,l),function t(e,n,i,o){if(i<=512||o<=512)return e.mmul(n);i%2==1&&o%2==1?(e=r(e,i+1,o+1),n=r(n,i+1,o+1)):i%2==1?(e=r(e,i+1,o),n=r(n,i+1,o)):o%2==1&&(e=r(e,i,o+1),n=r(n,i,o+1));let s=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,s-1,0,a-1),h=n.subMatrix(0,s-1,0,a-1),u=e.subMatrix(0,s-1,a,e.columns-1),c=n.subMatrix(0,s-1,a,n.columns-1),d=e.subMatrix(s,e.rows-1,0,a-1),f=n.subMatrix(s,n.rows-1,0,a-1),m=e.subMatrix(s,e.rows-1,a,e.columns-1),p=n.subMatrix(s,n.rows-1,a,n.columns-1),g=t(A.add(l,m),A.add(h,p),s,a),v=t(A.add(d,m),h,s,a),y=t(l,A.sub(c,p),s,a),w=t(m,A.sub(f,h),s,a),b=t(A.add(l,u),p,s,a),C=t(A.sub(d,l),A.add(h,c),s,a),S=t(A.sub(u,m),A.add(f,p),s,a),T=A.add(g,w);T.sub(b),T.add(S);let M=A.add(y,b),E=A.add(v,w),R=A.sub(g,v);R.add(y),R.add(C);let P=A.zeros(2*T.rows,2*T.columns);return P=P.setSubMatrix(T,0,0),P=P.setSubMatrix(M,T.rows,0),P=P.setSubMatrix(E,0,T.columns),P=P.setSubMatrix(R,T.rows,T.columns),P.subMatrix(0,i-1,0,o-1)}(e,t=r(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new P(this.rows,this.columns);for(let t=0;t<this.rows;t++){const o=this.getRow(t);o.length>0&&d(o,{min:e,max:n,output:o}),i.setRow(t,o)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new P(this.rows,this.columns);for(let t=0;t<this.columns;t++){const o=this.getColumn(t);o.length&&d(o,{min:e,max:n,output:o}),i.setColumn(t,o)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let n=0;n<t;n++){let t=this.get(e,n),i=this.get(e,this.columns-1-n);this.set(e,n,i),this.set(e,this.columns-1-n,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let n=0;n<t;n++){let t=this.get(n,e),i=this.get(this.rows-1-n,e);this.set(n,e,i),this.set(this.rows-1-n,e,t)}return this}kroneckerProduct(t){t=P.checkMatrix(t);let e=this.rows,n=this.columns,i=t.rows,o=t.columns,s=new P(e*i,n*o);for(let r=0;r<e;r++)for(let e=0;e<n;e++)for(let n=0;n<i;n++)for(let a=0;a<o;a++)s.set(i*r+n,o*e+a,this.get(r,e)*t.get(n,a));return s}kroneckerSum(t){if(t=P.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,n=t.rows,i=this.kroneckerProduct(P.eye(n,n)),o=P.eye(e,e).kroneckerProduct(t);return i.add(o)}transpose(){let t=new P(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(n,e,this.get(e,n));return t}sortRows(t=R){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=R){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,n,i){S(this,t,e,n,i);let o=new P(e-t+1,i-n+1);for(let s=t;s<=e;s++)for(let e=n;e<=i;e++)o.set(s-t,e-n,this.get(s,e));return o}subMatrixRow(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.columns-1),e>n||e<0||e>=this.columns||n<0||n>=this.columns)throw new RangeError("Argument out of range");let i=new P(t.length,n-e+1);for(let o=0;o<t.length;o++)for(let s=e;s<=n;s++){if(t[o]<0||t[o]>=this.rows)throw new RangeError(`Row index out of range: ${t[o]}`);i.set(o,s-e,this.get(t[o],s))}return i}subMatrixColumn(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.rows-1),e>n||e<0||e>=this.rows||n<0||n>=this.rows)throw new RangeError("Argument out of range");let i=new P(n-e+1,t.length);for(let o=0;o<t.length;o++)for(let s=e;s<=n;s++){if(t[o]<0||t[o]>=this.columns)throw new RangeError(`Column index out of range: ${t[o]}`);i.set(s-e,o,this.get(s,t[o]))}return i}setSubMatrix(t,e,n){if((t=P.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,n,n+t.columns-1);for(let i=0;i<t.rows;i++)for(let o=0;o<t.columns;o++)this.set(e+i,n+o,t.get(i,o));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let n=new P(t.length,e.length);for(let i=0;i<t.length;i++){let o=t[i];for(let t=0;t<e.length;t++){let s=e[t];n.set(i,t,this.get(o,s))}}return n}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let n=0;n<t;n++)e+=this.get(n,n);return e}clone(){let t=new P(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(e,n,this.get(e,n));return t}sum(t){switch(t){case"row":return function(t){let e=T(t.rows);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]+=t.get(n,i);return e}(this);case"column":return function(t){let e=T(t.columns);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]+=t.get(n,i);return e}(this);case void 0:return function(t){let e=0;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e+=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=T(t.rows,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]*=t.get(n,i);return e}(this);case"column":return function(t){let e=T(t.columns,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]*=t.get(n,i);return e}(this);case void 0:return function(t){let e=1;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e*=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:n=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof n)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,o=t.columns,s=[];for(let r=0;r<i;r++){let i=0,a=0,l=0;for(let e=0;e<o;e++)l=t.get(r,e)-n[r],i+=l,a+=l*l;e?s.push((a-i*i/o)/(o-1)):s.push((a-i*i/o)/o)}return s}(this,n,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,o=t.columns,s=[];for(let r=0;r<o;r++){let o=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,r)-n[r],o+=l,a+=l*l;e?s.push((a-o*o/i)/(i-1)):s.push((a-o*o/i)/i)}return s}(this,n,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,n){const i=t.rows,o=t.columns,s=i*o;let r=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<o;i++)l=t.get(e,i)-n,r+=l,a+=l*l;return e?(a-r*r/s)/(s-1):(a-r*r/s)/s}(this,n,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const n=this.variance(t,e);if(void 0===t)return Math.sqrt(n);for(let t=0;t<n.length;t++)n[t]=Math.sqrt(n[t]);return n}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:n=this.mean(t)}=e;switch(t){case"row":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[n])}(this,n),this;case"column":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[i])}(this,n),this;case void 0:if("number"!=typeof n)throw new TypeError("center must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let n=e.scale;switch(t){case"row":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.rows;n++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(n,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[n])}(this,n),this;case"column":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.columns;n++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,n),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[i])}(this,n),this;case void 0:if(void 0===n)n=function(t){const e=t.size-1;let n=0;for(let i=0;i<t.columns;i++)for(let o=0;o<t.rows;o++)n+=Math.pow(t.get(o,i),2)/e;return Math.sqrt(n)}(this);else if("number"!=typeof n)throw new TypeError("scale must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function R(t,e){return t-e}A.prototype.klass="Matrix","undefined"!=typeof Symbol&&(A.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),A.random=A.rand,A.randomInt=A.randInt,A.diagonal=A.diag,A.prototype.diagonal=A.prototype.diag,A.identity=A.eye,A.prototype.negate=A.prototype.neg,A.prototype.tensorProduct=A.prototype.kroneckerProduct;class P extends A{constructor(t,e){if(super(),P.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let n=0;n<t;n++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const n=t;if("number"!=typeof(e=(t=n.length)?n[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(n[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!n[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(n[i]))}}}this.rows=t,this.columns=e}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}removeRow(t){return y(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),y(this,t,!0),e=Float64Array.from(b(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const n=new Float64Array(this.columns-1);for(let i=0;i<t;i++)n[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)n[i-1]=this.data[e][i];this.data[e]=n}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=C(this,e);for(let n=0;n<this.rows;n++){const i=new Float64Array(this.columns+1);let o=0;for(;o<t;o++)i[o]=this.data[n][o];for(i[o++]=e[n];o<this.columns+1;o++)i[o]=this.data[n][o-1];this.data[n]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t.get(e,n));return this},t.add=function(t,n){return new e(t).add(n)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t.get(e,n));return this},t.sub=function(t,n){return new e(t).sub(n)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t.get(e,n));return this},t.mul=function(t,n){return new e(t).mul(n)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t.get(e,n));return this},t.div=function(t,n){return new e(t).div(n)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t.get(e,n));return this},t.mod=function(t,n){return new e(t).mod(n)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t.get(e,n));return this},t.and=function(t,n){return new e(t).and(n)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t.get(e,n));return this},t.or=function(t,n){return new e(t).or(n)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t.get(e,n));return this},t.xor=function(t,n){return new e(t).xor(n)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t.get(e,n));return this},t.leftShift=function(t,n){return new e(t).leftShift(n)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t.get(e,n));return this},t.signPropagatingRightShift=function(t,n){return new e(t).signPropagatingRightShift(n)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t.get(e,n));return this},t.rightShift=function(t,n){return new e(t).rightShift(n)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,n){return new e(t).pow(n)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t.get(e,n)));return this}}(A,P);class N extends A{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}}class x{constructor(t){let e,n,i,o,s,r,a,l,h,u=(t=N.checkMatrix(t)).clone(),c=u.rows,d=u.columns,f=new Float64Array(c),m=1;for(e=0;e<c;e++)f[e]=e;for(l=new Float64Array(c),n=0;n<d;n++){for(e=0;e<c;e++)l[e]=u.get(e,n);for(e=0;e<c;e++){for(h=Math.min(e,n),s=0,i=0;i<h;i++)s+=u.get(e,i)*l[i];l[e]-=s,u.set(e,n,l[e])}for(o=n,e=n+1;e<c;e++)Math.abs(l[e])>Math.abs(l[o])&&(o=e);if(o!==n){for(i=0;i<d;i++)r=u.get(o,i),u.set(o,i,u.get(n,i)),u.set(n,i,r);a=f[o],f[o]=f[n],f[n]=a,m=-m}if(n<c&&0!==u.get(n,n))for(e=n+1;e<c;e++)u.set(e,n,u.get(e,n)/u.get(n,n))}this.LU=u,this.pivotVector=f,this.pivotSign=m}isSingular(){let t=this.LU,e=t.columns;for(let n=0;n<e;n++)if(0===t.get(n,n))return!0;return!1}solve(t){t=P.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let n,i,o,s=t.columns,r=t.subMatrixRow(this.pivotVector,0,s-1),a=e.columns;for(o=0;o<a;o++)for(n=o+1;n<a;n++)for(i=0;i<s;i++)r.set(n,i,r.get(n,i)-r.get(o,i)*e.get(n,o));for(o=a-1;o>=0;o--){for(i=0;i<s;i++)r.set(o,i,r.get(o,i)/e.get(o,o));for(n=0;n<o;n++)for(i=0;i<s;i++)r.set(n,i,r.get(n,i)-r.get(o,i)*e.get(n,o))}return r}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,n=t.columns;for(let i=0;i<n;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new P(e,n);for(let o=0;o<e;o++)for(let e=0;e<n;e++)o>e?i.set(o,e,t.get(o,e)):o===e?i.set(o,e,1):i.set(o,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new P(e,n);for(let o=0;o<e;o++)for(let e=0;e<n;e++)o<=e?i.set(o,e,t.get(o,e)):i.set(o,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function L(t,e){let n=0;return Math.abs(t)>Math.abs(e)?(n=e/t,Math.abs(t)*Math.sqrt(1+n*n)):0!==e?(n=t/e,Math.abs(e)*Math.sqrt(1+n*n)):0}class G{constructor(t){let e,n,i,o,s=(t=N.checkMatrix(t)).clone(),r=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<r;e++)t=L(t,s.get(e,i));if(0!==t){for(s.get(i,i)<0&&(t=-t),e=i;e<r;e++)s.set(e,i,s.get(e,i)/t);for(s.set(i,i,s.get(i,i)+1),n=i+1;n<a;n++){for(o=0,e=i;e<r;e++)o+=s.get(e,i)*s.get(e,n);for(o=-o/s.get(i,i),e=i;e<r;e++)s.set(e,n,s.get(e,n)+o*s.get(e,i))}}l[i]=-t}this.QR=s,this.Rdiag=l}solve(t){t=P.checkMatrix(t);let e=this.QR,n=e.rows;if(t.rows!==n)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,o,s,r,a=t.columns,l=t.clone(),h=e.columns;for(s=0;s<h;s++)for(o=0;o<a;o++){for(r=0,i=s;i<n;i++)r+=e.get(i,s)*l.get(i,o);for(r=-r/e.get(s,s),i=s;i<n;i++)l.set(i,o,l.get(i,o)+r*e.get(i,s))}for(s=h-1;s>=0;s--){for(o=0;o<a;o++)l.set(s,o,l.get(s,o)/this.Rdiag[s]);for(i=0;i<s;i++)for(o=0;o<a;o++)l.set(i,o,l.get(i,o)-l.get(s,o)*e.get(i,s))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,n=this.QR,i=n.columns,o=new P(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?o.set(t,e,n.get(t,e)):t===e?o.set(t,e,this.Rdiag[t]):o.set(t,e,0);return o}get orthogonalMatrix(){let t,e,n,i,o=this.QR,s=o.rows,r=o.columns,a=new P(s,r);for(n=r-1;n>=0;n--){for(t=0;t<s;t++)a.set(t,n,0);for(a.set(n,n,1),e=n;e<r;e++)if(0!==o.get(n,n)){for(i=0,t=n;t<s;t++)i+=o.get(t,n)*a.get(t,e);for(i=-i/o.get(n,n),t=n;t<s;t++)a.set(t,e,a.get(t,e)+i*o.get(t,n))}}return a}}class _{constructor(t,e={}){if((t=N.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let n=t.rows,i=t.columns;const{computeLeftSingularVectors:o=!0,computeRightSingularVectors:s=!0,autoTranspose:r=!1}=e;let a,l=Boolean(o),h=Boolean(s),u=!1;if(n<i)if(r){a=t.transpose(),n=a.rows,i=a.columns,u=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let c=Math.min(n,i),d=Math.min(n+1,i),f=new Float64Array(d),m=new P(n,c),p=new P(i,i),g=new Float64Array(i),v=new Float64Array(n),y=new Float64Array(d);for(let t=0;t<d;t++)y[t]=t;let w=Math.min(n-1,i),b=Math.max(0,Math.min(i-2,n)),C=Math.max(w,b);for(let t=0;t<C;t++){if(t<w){f[t]=0;for(let e=t;e<n;e++)f[t]=L(f[t],a.get(e,t));if(0!==f[t]){a.get(t,t)<0&&(f[t]=-f[t]);for(let e=t;e<n;e++)a.set(e,t,a.get(e,t)/f[t]);a.set(t,t,a.get(t,t)+1)}f[t]=-f[t]}for(let e=t+1;e<i;e++){if(t<w&&0!==f[t]){let i=0;for(let o=t;o<n;o++)i+=a.get(o,t)*a.get(o,e);i=-i/a.get(t,t);for(let o=t;o<n;o++)a.set(o,e,a.get(o,e)+i*a.get(o,t))}g[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<n;e++)m.set(e,t,a.get(e,t));if(t<b){g[t]=0;for(let e=t+1;e<i;e++)g[t]=L(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<n&&0!==g[t]){for(let e=t+1;e<n;e++)v[e]=0;for(let e=t+1;e<n;e++)for(let n=t+1;n<i;n++)v[e]+=g[n]*a.get(e,n);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let o=t+1;o<n;o++)a.set(o,e,a.get(o,e)+i*v[o])}}if(h)for(let e=t+1;e<i;e++)p.set(e,t,g[e])}}let S=Math.min(i,n+1);if(w<i&&(f[w]=a.get(w,w)),n<S&&(f[S-1]=0),b+1<S&&(g[b]=a.get(b,S-1)),g[S-1]=0,l){for(let t=w;t<c;t++){for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==f[t]){for(let e=t+1;e<c;e++){let i=0;for(let o=t;o<n;o++)i+=m.get(o,t)*m.get(o,e);i=-i/m.get(t,t);for(let o=t;o<n;o++)m.set(o,e,m.get(o,e)+i*m.get(o,t))}for(let e=t;e<n;e++)m.set(e,t,-m.get(e,t));m.set(t,t,1+m.get(t,t));for(let e=0;e<t-1;e++)m.set(e,t,0)}else{for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<b&&0!==g[t])for(let e=t+1;e<i;e++){let n=0;for(let o=t+1;o<i;o++)n+=p.get(o,t)*p.get(o,e);n=-n/p.get(t+1,t);for(let o=t+1;o<i;o++)p.set(o,e,p.get(o,e)+n*p.get(o,t))}for(let e=0;e<i;e++)p.set(e,t,0);p.set(t,t,1)}let T=S-1,M=0,E=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+E*Math.abs(f[t]+Math.abs(f[t+1]));if(Math.abs(g[t])<=e||Number.isNaN(g[t])){g[t]=0;break}}if(t===S-2)e=4;else{let n;for(n=S-1;n>=t&&n!==t;n--){let e=(n!==S?Math.abs(g[n]):0)+(n!==t+1?Math.abs(g[n-1]):0);if(Math.abs(f[n])<=E*e){f[n]=0;break}}n===t?e=3:n===S-1?e=1:(e=2,t=n)}switch(t++,e){case 1:{let e=g[S-2];g[S-2]=0;for(let n=S-2;n>=t;n--){let o=L(f[n],e),s=f[n]/o,r=e/o;if(f[n]=o,n!==t&&(e=-r*g[n-1],g[n-1]=s*g[n-1]),h)for(let t=0;t<i;t++)o=s*p.get(t,n)+r*p.get(t,S-1),p.set(t,S-1,-r*p.get(t,n)+s*p.get(t,S-1)),p.set(t,n,o)}break}case 2:{let e=g[t-1];g[t-1]=0;for(let i=t;i<S;i++){let o=L(f[i],e),s=f[i]/o,r=e/o;if(f[i]=o,e=-r*g[i],g[i]=s*g[i],l)for(let e=0;e<n;e++)o=s*m.get(e,i)+r*m.get(e,t-1),m.set(e,t-1,-r*m.get(e,i)+s*m.get(e,t-1)),m.set(e,i,o)}break}case 3:{const e=Math.max(Math.abs(f[S-1]),Math.abs(f[S-2]),Math.abs(g[S-2]),Math.abs(f[t]),Math.abs(g[t])),o=f[S-1]/e,s=f[S-2]/e,r=g[S-2]/e,a=f[t]/e,u=g[t]/e,c=((s+o)*(s-o)+r*r)/2,d=o*r*(o*r);let v=0;0===c&&0===d||(v=c<0?0-Math.sqrt(c*c+d):Math.sqrt(c*c+d),v=d/(c+v));let y=(a+o)*(a-o)+v,w=a*u;for(let e=t;e<S-1;e++){let o=L(y,w);0===o&&(o=Number.MIN_VALUE);let s=y/o,r=w/o;if(e!==t&&(g[e-1]=o),y=s*f[e]+r*g[e],g[e]=s*g[e]-r*f[e],w=r*f[e+1],f[e+1]=s*f[e+1],h)for(let t=0;t<i;t++)o=s*p.get(t,e)+r*p.get(t,e+1),p.set(t,e+1,-r*p.get(t,e)+s*p.get(t,e+1)),p.set(t,e,o);if(o=L(y,w),0===o&&(o=Number.MIN_VALUE),s=y/o,r=w/o,f[e]=o,y=s*g[e]+r*f[e+1],f[e+1]=-r*g[e]+s*f[e+1],w=r*g[e+1],g[e+1]=s*g[e+1],l&&e<n-1)for(let t=0;t<n;t++)o=s*m.get(t,e)+r*m.get(t,e+1),m.set(t,e+1,-r*m.get(t,e)+s*m.get(t,e+1)),m.set(t,e,o)}g[S-2]=y,M+=1;break}case 4:if(f[t]<=0&&(f[t]=f[t]<0?-f[t]:0,h))for(let e=0;e<=T;e++)p.set(e,t,-p.get(e,t));for(;t<T&&!(f[t]>=f[t+1]);){let e=f[t];if(f[t]=f[t+1],f[t+1]=e,h&&t<i-1)for(let n=0;n<i;n++)e=p.get(n,t+1),p.set(n,t+1,p.get(n,t)),p.set(n,t,e);if(l&&t<n-1)for(let i=0;i<n;i++)e=m.get(i,t+1),m.set(i,t+1,m.get(i,t)),m.set(i,t,e);t++}M=0,S--}}if(u){let t=p;p=m,m=t}this.m=n,this.n=i,this.s=f,this.U=m,this.V=p}solve(t){let e=t,n=this.threshold,i=this.s.length,o=P.zeros(i,i);for(let t=0;t<i;t++)Math.abs(this.s[t])<=n?o.set(t,t,0):o.set(t,t,1/this.s[t]);let s=this.U,r=this.rightSingularVectors,a=r.mmul(o),l=r.rows,h=s.rows,u=P.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let n=0;for(let o=0;o<i;o++)n+=a.get(t,o)*s.get(e,o);u.set(t,e,n)}return u.mmul(e)}solveForDiagonal(t){return this.solve(P.diag(t))}inverse(){let t=this.V,e=this.threshold,n=t.rows,i=t.columns,o=new P(n,this.s.length);for(let s=0;s<n;s++)for(let n=0;n<i;n++)Math.abs(this.s[n])>e&&o.set(s,n,t.get(s,n)/this.s[n]);let s=this.U,r=s.rows,a=s.columns,l=new P(n,r);for(let t=0;t<n;t++)for(let e=0;e<r;e++){let n=0;for(let i=0;i<a;i++)n+=o.get(t,i)*s.get(e,i);l.set(t,e,n)}return l}get condition(){return 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ot,st,rt,at,lt=n(3979);(at=ot||(ot={})).Levenshtein="Levenshtein",at.JaroWinkler="Jaro-Winkler",at.Manhattan="Manhattan",function(t){t.Euclidean="Euclidean"}(st||(st={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean"}(rt||(rt={}));const ht={[st.Euclidean]:E.dP},ut={[ot.Levenshtein]:(t,e)=>{if(t.length<e.length){const n=e;e=t,t=n}return 0===e.length?t.length:t.length<=32?((t,e)=>{const n=t.length,i=e.length,o=1<<n-1;let s=-1,r=0,a=n,l=n;for(;l--;)it[t.charCodeAt(l)]|=1<<l;for(l=0;l<i;l++){let t=it[e.charCodeAt(l)];const n=t|r;t|=(t&s)+s^s,r|=~(t|s),s&=t,r&o&&a++,s&o&&a--,r=r<<1|1,s=s<<1|~(n|r),r&=n}for(l=n;l--;)it[t.charCodeAt(l)]=0;return a})(t,e):((t,e)=>{const n=e.length,i=t.length,o=[],s=[],r=Math.ceil(n/32),a=Math.ceil(i/32);for(let t=0;t<r;t++)s[t]=-1,o[t]=0;let l=0;for(;l<a-1;l++){let r=0,a=-1;const h=32*l,u=Math.min(32,i)+h;for(let e=h;e<u;e++)it[t.charCodeAt(e)]|=1<<e;for(let t=0;t<n;t++){const n=it[e.charCodeAt(t)],i=s[t/32|0]>>>t&1,l=o[t/32|0]>>>t&1,h=n|r,u=((n|l)&a)+a^a|n|l;let c=r|~(u|a),d=a&u;c>>>31^i&&(s[t/32|0]^=1<<t),d>>>31^l&&(o[t/32|0]^=1<<t),c=c<<1|i,d=d<<1|l,a=d|~(h|c),r=c&h}for(let e=h;e<u;e++)it[t.charCodeAt(e)]=0}let h=0,u=-1;const c=32*l,d=Math.min(32,i-c)+c;for(let e=c;e<d;e++)it[t.charCodeAt(e)]|=1<<e;let f=i;for(let t=0;t<n;t++){const n=it[e.charCodeAt(t)],r=s[t/32|0]>>>t&1,a=o[t/32|0]>>>t&1,l=n|h,c=((n|a)&u)+u^u|n|a;let d=h|~(c|u),m=u&c;f+=d>>>i-1&1,f-=m>>>i-1&1,d>>>31^r&&(s[t/32|0]^=1<<t),m>>>31^a&&(o[t/32|0]^=1<<t),d=d<<1|r,m=m<<1|a,u=m|~(l|d),h=d&l}for(let e=c;e<d;e++)it[t.charCodeAt(e)]=0;return f})(t,e)},[ot.JaroWinkler]:lt.H$,[ot.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let n=0;for(let i=1;i<t.length;i++)n+=t[i]==e[i]?0:1;return n/t.length}}},ct={[rt.Tanimoto]:function(t,e){return L(function(t,e){const n=t.trueCount()+e.trueCount();if(0==n)return 1;const i=t.andWithCountBits(e,!0);return i/(n-i)}(t,e))},[rt.Dice]:function(t,e){return L(function(t,e){const n=t.trueCount()+e.trueCount();return 0==n?0:2*t.andWithCountBits(e,!0)/n}(t,e))},[rt.Asymmetric]:function(t,e){return L(function(t,e){const n=Math.min(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))},[rt.BraunBlanquet]:function(t,e){return L(function(t,e){const n=Math.max(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))},[rt.Cosine]:function(t,e){return L(function(t,e){const n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)/Math.sqrt(n)}(t,e))},[rt.Kulczynski]:function(t,e){return L(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*n/(2*i)}(t,e))},[rt.McConnaughey]:function(t,e){return L(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*n-i)/i}(t,e))},[rt.RogotGoldberg]:function(t,e){return L(function(t,e){const n=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),o=t.length,s=o-i+n;return n==o||s==o?1:n/i+s/(2*o-i)}(t,e))},[rt.Russel]:function(t,e){return L(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))},[rt.Sokal]:function(t,e){return L(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*n-3*i)}(t,e))},[rt.Hamming]:function(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)},[rt.Euclidean]:function(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}};var dt,ft;(ft=dt||(dt={})).Vector="Vector",ft.String="String",ft.BitArray="BitArray";const mt={[dt.Vector]:{[st.Euclidean]:ht[st.Euclidean]},[dt.String]:{[ot.Levenshtein]:ut[ot.Levenshtein],[ot.JaroWinkler]:ut[ot.JaroWinkler],[ot.Manhattan]:ut[ot.Manhattan]},[dt.BitArray]:{[rt.Tanimoto]:ct[rt.Tanimoto],[rt.Dice]:ct[rt.Dice],[rt.Asymmetric]:ct[rt.Asymmetric],[rt.BraunBlanquet]:ct[rt.BraunBlanquet],[rt.Cosine]:ct[rt.Cosine],[rt.Kulczynski]:ct[rt.Kulczynski],[rt.McConnaughey]:ct[rt.McConnaughey],[rt.RogotGoldberg]:ct[rt.RogotGoldberg],[rt.Russel]:ct[rt.Russel],[rt.Sokal]:ct[rt.Sokal]}};Object.keys(mt).reduce(((t,e)=>{for(const n of Object.keys(mt[e]))t[n]=e;return t}),{});var pt=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function gt(t,e,n,o,r){return pt(this,void 0,void 0,(function*(){e.version!==e.temp["last-invalidated-version"]&&(yield(0,A.HV)(e,!1));const n=s.DataFrame.create(e.length);return n.columns.addNewString(o).init((t=>e.temp["monomeric-mols"].get(t))),yield i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:n,colName:o,simArr:r})}))}function vt(t){const e=o.divH([]),n=o.divV([o.divText(t.seqCol.name),o.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.line.mols.forEach(((n,i)=>{const s=o.divText(t.activityCol.get(n).toFixed(2));s.style.display="flex",s.style.justifyContent="left",s.style.paddingLeft="30px",e.append(o.divV([o.divText(t.seqCol.get(n)),s]))})),e}function yt(t){const e=o.div();e.append(o.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2),i=new Array(2);t.line.mols.forEach(((e,o)=>{n[o]=t.seqCol.get(e),i[o]=t.activityCol.get(e)}));const a={},l=t.seqCol.getTag(s.TAGS.UNITS),h=t.seqCol.getTag("separator"),u=(0,r.vU)(l,h),c=function(t,e,n,i){const o=document.createElement("canvas"),s=o.getContext("2d");return o.height=30,g(s,0,0,0,30,t,e,n,!0,i),o}(u(n[0]),u(n[1]),l,a);return e.append(o.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(function(t){const e=o.div();if(Object.keys(t).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}(a)),e.append(wt("Activity delta",Math.abs(i[0]-i[1]))),e.append(wt("Cliff",t.sali)),e}function wt(t,e){return o.divH([o.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function bt(t,e){const n=s.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(s.TAGS.UNITS,t.col(e[0]).getTag(s.TAGS.UNITS)),n.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}n(1047),n(4004),n(7228),n(7767);var Ct=n(5226);n(9133);class St extends s.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[DG.TAGS.UNITS,"aligned","separator","alphabet"],this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",CHEM_SIMILARITY_METRICS[0],{choices:CHEM_SIMILARITY_METRICS}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}onTableAttached(){return sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){if(this.init(),this.dataFrame){this.subs.push(DG.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render()})))));const t="diversity"!==this.name;this.subs.push(DG.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(t)}))))),this.subs.push(DG.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.subs.push(DG.debounce(ui.onSizeChanged(this.root),50).subscribe((t=>sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.moleculeColumn=this.dataFrame.columns.bySemType(DG.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=(this.moleculeColumn,void 0),this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}yield this.render()}))}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===DG.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){return sequence_search_base_viewer_awaiter(this,void 0,void 0,(function*(){}))}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==DG.SEMTYPE.MACROMOLECULE&&(grok.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}n(7241);var Tt=n(4293);n(9943),n(4413);var Mt,Et=n(1061),At=n(8341),Rt=n(499),Pt=(n(1345),n(4221),n(7659),n(3659),n(4588));class Nt{constructor(t){var e,n,i,o,s,r,a;this.steps=null!==(e=null==t?void 0:t.steps)&&void 0!==e?e:0,this.cycles=null!==(n=null==t?void 0:t.cycles)&&void 0!==n?n:1e6,this.cutoff=null!==(i=null==t?void 0:t.cutoff)&&void 0!==i?i:0,this.lambda=null!==(o=null==t?void 0:t.lambda)&&void 0!==o?o:2,this.dlambda=null!==(s=null==t?void 0:t.dlambda)&&void 0!==s?s:.01,this.lambda2=this.lambda/2,this.dlambda2=this.dlambda/2,this.epsilon=null!==(r=null==t?void 0:t.epsilon)&&void 0!==r?r:1e-10,this.distanceFunction=null!==(a=null==t?void 0:t.distance)&&void 0!==a?a:E.dP,this.distance=[]}initDistance(t){this.distance=(0,E.H3)(t,this.distanceFunction)}calcDistance(t,e,n){return this.distance[e][n]}embed(t){const e=t.length,n=(0,E.kO)(e,Nt.dimension,40);let i=this.lambda2;0==this.steps&&(this.steps=t.length-1),this.initDistance(t);for(let o=0;o<this.cycles;++o){for(let o=0;o<this.steps;++o){const o=(0,Pt.I)(e);let s=(0,Pt.I)(e);for(;o==s;)s=(0,Pt.I)(e);const r=n[o],a=n[s],l=this.calcDistance(t,o,s),h=(0,E.dP)(r,a);if(0==this.cutoff||l<=this.cutoff||h<l){const t=i*(l-h)/(h+this.epsilon),e=(0,E.On)(r,a,-1);n[o]=(0,E.On)(r,e,t),n[s]=(0,E.On)(a,e,-t)}}if(i-=this.dlambda2,i<=0)break}return n}}Nt.dimension=2;class xt{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const n=t,i=xt._createBuffer(n);if(e)for(let t=0;t<i.length;t++)i[t]=-1;this._data=i,this._length=n}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,n,i){if(t<e||t>n)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${n})`)}copy(t,e,n){for(let i=0;i<n;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const n=new xt(t._length);n._length=t._length,n._data=xt._createBuffer(n._length),n._version=0;const i=t.lengthInInts;for(let o=0;o<i;o++)n._data[o]=t._data[o]&e._data[o];return n}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new xt(t.length);e._version=0;for(let n=0;n<e._length;n++)t[n]&&(e._data[Math.floor(n/32)]|=1<<(n%32&31));return e}static fromSeq(t,e){const n=new xt(t);for(let i=0;i<t;++i)n.setBit(i,e(i));return n._version=0,n}static fromString(t){return xt.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const n=new xt(t);return n._data=e,n}static fromBytes(t){const e=t.length,n=new xt(8*e);n._data=new Uint32Array(Math.floor((e+3)/4)),n._length=8*e;let i=0,o=0;for(;e-o>=4;)n._data[i++]=255&t[o]|(255&t[o+1])<<8|(255&t[o+2])<<16|(255&t[o+3])<<24,o+=4;return e-o==3&&(n._data[i]=(255&t[o+2])<<16),e-o==2&&(n._data[i]|=(255&t[o+1])<<8),e-o==1&&(n._data[i]|=255&t[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new xt(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,i=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,i=!0,o=!0){if(n&&o&&this.setAll(!e,!1),o)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return xt.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return n}setRange(t,e,n,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const o=Math.min(t,e),s=Math.max(t,e);if(n)for(let t=o;t<=s;t++)this.setTrue(t);else for(let t=o;t<=s;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths 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s.Column.bool(o,t.rowCount).init((t=>e.has(t)))}(t,_.cliffsMolIds);t.columns.add(W);const F=function(t){const e=t.filter((t=>t!==1/0)),n=Math.min(...e);return{max:Math.max(...e),min:n}}(_.saliVals),k=.8/(F.max-F.min),D=i.shell.getTableView(t.name);D.grid.columns.byName(W.name).visible=!1;const H=D.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:I.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),V=H.getInfo().canvas,O=function(t,e,n,i,o){const r=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const n=t.n1[e],i=t.n2[e];r[e]={id:e,mols:[n,i],selected:!1,a:[],b:[]}}const a=s.DataFrame.create(r.length);return Q.forEach(((t,n)=>{a.columns.addNewString(t).init((t=>e.get(r[t].mols[n]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(a.col(t),o),a.col(t).semType=i})),a.columns.addNewFloat(X).init((t=>Math.abs(n.get(r[t].mols[0])-n.get(r[t].mols[1])))),a.columns.addNewInt(J).init((t=>t)),a.columns.addNewFloat(q).init((e=>t.saliVals[e])),a.columns.addNewFloat(j).init((e=>t.simVals[e])),{lines:r,linesDf:a}}(_,e,h,f,m),Y=w?w(O.linesDf,Q).sort([q],[!1]):O.linesDf.plot.grid().sort([q],[!1]);t.temp[".cliffsDfGrid"]=Y;const U=o.button(`${O.linesDf.rowCount} cliffs`,(()=>{D.dockManager.dock(Y.root,"down",null,"Activity cliffs",.2)}));U.classList.add("scatter_plot_link","cliffs_grid"),H.root.append(U);const B=o.switchInput("Show only 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this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.splitter=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=y.viewerCount,y.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(o.sequenceColumnName,v.sequenceColumnName,{category:i.DATA}),this.startPositionName=this.string(o.startPositionName,v.startPositionName,{category:i.DATA}),this.endPositionName=this.string(o.endPositionName,v.endPositionName,{category:i.DATA}),this.skipEmptySequences=this.bool(o.skipEmptySequences,v.skipEmptySequences,{category:i.DATA}),this.skipEmptyPositions=this.bool(o.skipEmptyPositions,v.skipEmptyPositions,{category:i.DATA}),this.shrinkEmptyTail=this.bool(o.shrinkEmptyTail,v.shrinkEmptyTail,{category:i.DATA}),this.backgroundColor=this.int(o.backgroundColor,v.backgroundColor,{category:i.STYLE}),this.positionHeight=this.string(o.positionHeight,v.positionHeight,{category:i.STYLE,choices:Object.values(f.ES)}),this._positionWidth=this.positionWidth=this.float(o.positionWidth,v.positionWidth,{category:i.STYLE}),this.verticalAlignment=this.string(o.verticalAlignment,v.verticalAlignment,{category:i.LAYOUT,choices:Object.values(f.vw)}),this.horizontalAlignment=this.string(o.horizontalAlignment,v.horizontalAlignment,{category:i.LAYOUT,choices:Object.values(f.iD)}),this.fixWidth=this.bool(o.fixWidth,v.fixWidth,{category:i.LAYOUT}),this.fitArea=this.bool(o.fitArea,v.fitArea,{category:i.LAYOUT}),this.minHeight=this.float(o.minHeight,v.minHeight,{category:i.LAYOUT}),this.maxHeight=this.float(o.maxHeight,v.maxHeight,{category:i.LAYOUT}),this.positionMarginState=this.string(o.positionMarginState,v.positionMarginState,{category:i.LAYOUT,choices:Object.values(f.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(o.positionMargin,t,{category:i.LAYOUT,min:0,max:16}),this.filterSource=this.string(o.filterSource,v.filterSource,{category:i.BEHAVIOR,choices:Object.values(f.Ct)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.style.width="100%"}init(){this.initialized?console.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message"),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=r.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(u.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(u.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(u.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame)if(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol){const t=this.seqCol.getTag(a.TAGS.UNITS),e=this.seqCol.getTag("separator");this.splitter=(0,d.vU)(t,e),this.unitsHandler=new c.C(this.seqCol),this.updatePositions(),this.cp=(0,d.dQ)(this.seqCol)}else this.splitter=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null;this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...t.map((t=>null!==t?this.splitter(t).length:0))):0,n=this.seqCol.getTag(f.DX.positionNames);this.positionNames=n?n.split(f.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),n=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,n=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,n)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case o.sequenceColumnName:case o.startPositionName:case o.endPositionName:case o.filterSource:this.updateSeqCol();break;case o.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case o.fixWidth:case o.fitArea:case o.positionMargin:this.updateSlider();break;case o.shrinkEmptyTail:case o.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){super.onTableAttached();const t=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),this.updateSeqCol(),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}detach(){const t=Object.create(null,{detach:{get:()=>super.detach}});return e=this,n=void 0,o=function*(){const e=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${e} ) start`),t.detach.call(this),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)},new((i=void 0)||(i=Promise))((function(t,s){function r(t){try{l(o.next(t))}catch(t){s(t)}}function a(t){try{l(o.throw(t))}catch(t){s(t)}}function l(e){var n;e.done?t(e.value):(n=e.value,n instanceof i?n:new i((function(t){t(n)}))).then(r,a)}l((o=o.apply(e,n||[])).next())}));var e,n,i,o}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,n=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),i=this.positions[n];if(null==i)return[n,null,null];const o=Object.keys(i.freq).find((n=>i.freq[n].bounds.contains(e,t.y)));return void 0===o?[n,null,null]:[n,o,i.freq[o]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const n=t.length;let i=0;for(let o=0;o<n;o++)e(t[o])||(t[i]=t[o],i++);return t.length=i,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>{var e;return(null===(e=null==t?void 0:t.freq["-"])||void 0===e?void 0:e.count)===t.rowCount}))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=new c.C(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new g(this.startPosition+t,e)}const n=this.filter.getSelectedIndexes();this.rowsMasked=n.length,this.rowsNull=0;for(const t of n){let e=this.seqCol.get(t);e||(e=this._nullSequence(),++this.rowsNull);const n=this.splitter(e);for(let t=0;t<this.Length;t++){const e=this.positions[t].freq,i=n[this.startPosition+t]||"-";i in e||(e[i]=new p),e[i].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==f.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const n=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-n*Math.log2(n)}}}this._removeEmptyPositions();const i=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const n=this.positions[e].freq,o=this.positions[e].rowCount,r=this.getAlphabetSize();this.positionHeight==f.ES.Entropy&&null==r&&s.shell.error("WebLogo: alphabet is undefined.");const l=Math.log2(r),h=this.positionHeight==f.ES.Entropy?i*(l-this.positions[e].sumForHeightCalc)/l:i;let u=this.axisHeight*t+(i-h-1);const c=Object.entries(n).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of c){const n=t[1],i=h*n.count/o;n.bounds=new a.Rect(e*this.positionWidthWithMargin,u,this._positionWidth,i),u+=i}}}render(t=!0){var e;if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const n=this.canvas.getContext("2d");if(!n)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio;t&&this._calculate(i),n.resetTransform(),n.fillStyle=a.Color.toHtml(this.backgroundColor),n.fillRect(0,0,this.canvas.width,this.canvas.height),n.textBaseline=this.textBaseline;const o=this.countOfRenderPositions+1,s=this.visibleSlider?Math.floor(this.slider.min):0,r=Math.min(this.Length,s+o),l=10*i;n.resetTransform(),n.fillStyle="black",n.textAlign="center",n.font=`${l.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const h=Math.max(...this.positions.map((t=>n.measureText(t.name).width))),u=h<this._positionWidth-2?1:(this._positionWidth-2)/h;for(let t=this.firstVisibleIndex;t<r;t++){const e=this.positions[t];n.resetTransform(),n.setTransform(u,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*s,0),n.fillText(e.name,0,0)}for(let t=this.firstVisibleIndex;t<r;t++)for(const[i,o]of Object.entries(this.positions[t].freq))if("-"!==i){const t=(0,d.GU)(i,5),s=o.bounds,r=s.left-this.positionWidthWithMargin*this.firstVisibleIndex;n.resetTransform(),n.strokeStyle="lightgray",n.lineWidth=1,n.rect(r,s.top,s.width,s.height),n.fillStyle=null!==(e=this.cp.get(i))&&void 0!==e?e:this.cp.get("other"),n.textAlign="left",n.font="16px Roboto, Roboto Local, sans-serif";const a=n.measureText(t);n.setTransform(s.width/a.width,0,0,s.height/12.2,r,s.top),n.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,n=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,n*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${n}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let o=0;switch(this.verticalAlignment){case"top":o=0;break;case"middle":o=Math.max(0,(this.root.clientHeight-n)/2);break;case"bottom":o=Math.max(0,this.root.clientHeight-n-t)}let s=0;switch(this.horizontalAlignment){case"left":s=0;break;case"center":s=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":s=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${o}px`,"important"),this.host.style.setProperty("margin-left",`${s}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${o+i}px`,"important"),this.root.clientHeight<=n?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){var t,e;return null!==(e=null===(t=this.unitsHandler)||void 0===t?void 0:t.getAlphabetSize())&&void 0!==e?e:0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,n=window.devicePixelRatio,i=this.canvas.getCursorPosition(e,n),[o,s]=this.getMonomer(i);if(this.dataFrame&&this.seqCol&&this.splitter&&s){const t=this.positions[o],n=w(this.dataFrame,this.seqCol,this.filter,this.splitter,s,t),i=r.div([r.div(`${s}`),r.div(`${n} rows`)]);r.tooltip.show(i,e.x+16,e.y+16)}else r.tooltip.hide()}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(e,n));if(this.dataFrame&&this.seqCol&&this.splitter&&o){const t=this.positions[i],e=a.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,n,i,o,s,r){if(!n.getSelectedIndexes().includes(i))return!1;const a=e.get(i),l=a?o(a)[r.pos]:null;return l===s||""===l&&"-"===s}(this.dataFrame,this.seqCol,this.filter,e,this.splitter,o,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const e=t.deltaY/100*Math.max(Math.floor(this.countOfRenderPositions/2),1);this.slider.scrollBy(this.slider.min+e)}catch(t){const e=(0,m.O)(t);console.error("Bio: WebLogoViewer.canvasOnWheel() error:\n"+e)}}}function w(t,e,n,i,o,s){return h().count(0).take(t.rowCount).filter((t=>n.get(t))).map((t=>{const n=e.get(t),o=n?i(n):[],r=s.pos;return r<o.length?o[r]:null})).toArray().filter((t=>t==o)).reduce(((t,e)=>t+1),0)}y.residuesSet="nucleotides",y.viewerCount=-1},4413:(t,e,n)=>{"use strict";n.d(e,{ST:()=>m});var i=n(3870),o=n(976),s=n(4469),r=n(6414),a=n.n(r),l=n(7983),h=n(701),u=n(4293),c=n(1061);const d=rxjs.operators;var f=function(t,e,n,i){return new(n||(n=Promise))((function(o,s){function r(t){try{l(i.next(t))}catch(t){s(t)}}function a(t){try{l(i.throw(t))}catch(t){s(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class m extends o.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){var e,n,i,s,r;super.attach(t),this.column=t.columns.bySemType(o.SEMTYPE.MACROMOLECULE),null!==(e=this.columnName)&&void 0!==e||(this.columnName=null===(n=this.column)||void 0===n?void 0:n.name),null!==(i=this.notation)&&void 0!==i||(this.notation=null===(s=this.column)||void 0===s?void 0:s.getTag(o.TAGS.UNITS)),this.bioFilter="fasta"===this.notation?new g:"separator"===this.notation?new v(this.column.getTag("separator")):new y,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),null===(r=this.onBioFilterChangedSubs)||void 0===r||r.unsubscribe();let a=this.bioFilter.onChanged;a=a.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=a.subscribe((t=>f(this,void 0,void 0,(function*(){return yield this._onInputChanged()}))))}detach(){super.detach()}applyFilter(){var t;this.bitset&&!this.isDetached&&(null===(t=this.dataFrame)||void 0===t||t.filter.and(this.bitset))}saveState(){var t;const e=super.saveState();return e.bioSubstructure=null===(t=this.bioFilter)||void 0===t?void 0:t.substructure,e}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}_onInputChanged(){var t,e,n;return f(this,void 0,void 0,(function*(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=yield null===(e=this.bioFilter)||void 0===e?void 0:e.substrucrureSearch(this.column),this.calculating=!1,null===(n=this.dataFrame)||void 0===n||n.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,null===(t=this.dataFrame)||void 0===t||t.rows.requestFilter()}))}}class p{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return null}))}}class g extends p{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return yield(0,l.pf)(this.substructure,t)}))}}class v extends g{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return yield(0,l.pf)(this.substructure,t,this.colSeparator)}))}}class y extends p{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}init(){return f(this,void 0,void 0,(function*(){this.helmEditor=yield s.functions.call("HELM:helmWebEditor"),yield i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:n}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const 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