@datagrok/bio 2.4.45 → 2.4.46

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (17) hide show
  1. package/dist/79.js +2 -0
  2. package/dist/79.js.map +1 -0
  3. package/dist/package-test.js +1 -1
  4. package/dist/package-test.js.map +1 -1
  5. package/dist/package.js +1 -1
  6. package/dist/package.js.map +1 -1
  7. package/package.json +10 -2
  8. package/src/package-types.ts +40 -0
  9. package/src/package.ts +33 -5
  10. package/src/tests/msa-tests.ts +0 -3
  11. package/src/utils/cell-renderer-consts.ts +27 -0
  12. package/src/utils/cell-renderer.ts +7 -6
  13. package/src/widgets/package-settings-editor-widget.ts +28 -0
  14. package/src/widgets/representations.ts +18 -3
  15. /package/files/{libraries → tests/libraries}/broken-lib.sdf +0 -0
  16. /package/files/{libraries → tests/libraries}/group1/mock-lib-3.json +0 -0
  17. /package/files/{libraries → tests/libraries}/mock-lib-2.json +0 -0
package/dist/package.js CHANGED
@@ -1,2 +1,2 @@
1
- var bio;(()=>{var t={8867:(t,e,n)=>{"use strict";n.d(e,{OW:()=>i});class i extends Float32Array{}},7997:(t,e,n)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}n.d(e,{$G:()=>s,MA:()=>r,hu:()=>i}),n(8867)},2012:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(9976);class s extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,s)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,s)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new s({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in s.aaSynonyms?s.aaSynonyms[t]:t;return super.get(e)}}s.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return s.GrokGroups;case"lesk":return s.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const s of t)"("==s?e++:")"==s?e--:e?n+=s:i+=s;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){var n,i,s;const r=this.getPalette(e);let[o,a]=this.getInnerOuter(t);if(o=o.length>6?`${o.slice(0,3)}...`:o,a=a.length>6?`${a.slice(0,3)}...`:a,1==t.length||"("==t[1]){const e=null===(n=t[0])||void 0===n?void 0:n.toUpperCase();return e in r?[r.get(e),e,a,1]:[this.undefinedColor,o,a,1]}if("d"==t[0]&&t[1]in r&&(2==t.length||"("==t[2])){const e=null===(i=t[1])||void 0===i?void 0:i.toUpperCase();return e in r?[r.get(e),e,a,2]:[this.undefinedColor,o,a,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in r?[r.get(e),e,a,3]:[this.undefinedColor,o,a,3]}if((null===(s=t[0])||void 0===s?void 0:s.toLowerCase())==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in r?[r.get(e),e,a,4]:[this.undefinedColor,o,a,4]}return[this.undefinedColor,o,a,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,n)=>{"use strict";n.d(e,{JN:()=>a,Xk:()=>o});var i=n(976),s=(n(4469),n(1047)),r=(n(585),function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))});function o(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(s.K4).forEach((e=>{if("symbol"===e){const r=t.get(s.K4[e],n);i[e]="."===r?t.get(s.At,n):r}else if("rgroups"===e){const r=t.get(s.K4[e],n).split("\n"),o=[];r.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else s.K4[e]&&(i[e]=t.get(s.K4[e],n))})),e.push(i)}return e}function a(){return r(this,void 0,void 0,(function*(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installer for MonomerLibraryHelper.');return(yield t[0].prepare().call()).getOutputParamValue()}))}},2098:(t,e,n)=>{"use strict";n.d(e,{j:()=>i});class i{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const n=this.monomerLib.getMonomer(t,e);return n?n.molfile:null}}},1731:(t,e,n)=>{"use strict";n.d(e,{i0:()=>P});var i=n(4469),s=n(976),r=n(1047),o=n(585),a=n(7767);function l(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?l(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var h=n(499),c=function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};const u=8,m="M RGP",d="A ",f=14,p=7,g="\nDatagrok macromolecule handler\n\n",y=" 0 0 0 0 0 0 999 V3000\n",b="M V30 BEGIN CTAB\n",w="M V30 END CTAB\n",v="M V30 COUNTS ",C=" 0 0 0\n",S="M V30 BEGIN ATOM\n",M="M V30 END ATOM\n",T="M V30 BEGIN BOND\n",x="M V30 END BOND\n",E=" CFG=",N="M V30 ",A="M END",I=1e4,L="d",k="r",_="p",R="O",O="H";function P(t,e,n){return c(this,void 0,void 0,(function*(){if(0===s.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${s.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let u=e;h.C.getOrCreate(e).isHelm()&&(u=new a.L(e).convert("separator","."),u.name=e.name);const m=h.C.getOrCreate(u).alphabet;let d;if("PT"===m||"UN"===m)d="PEPTIDE";else{if("RNA"!==m&&"DNA"!==m)return{col:null,warnings:[`Unexpected column's '${u.name}' alphabet '${m}'.`]};d="RNA"}const f=function(t){const e=t.length,n=new Array(e),i=t.getTag(s.TAGS.UNITS),r=t.getTag("separator"),a=(0,o.vU)(i,r);for(let i=0;i<e;++i){const e=t.get(i);n[i]=e?a(e).filter((t=>""!==t)):[]}return n}(u),p=yield function(t,e,n,s){return c(this,void 0,void 0,(function*(){const o=function(t,e,n){const i=new Map;for(const s of t.getMonomerSymbolsByType(e)){const o=t.getMonomer(e,s);if("RNA"===e&&("Branch"===o.monomerType||"DNA"===n&&o.symbol===L||"RNA"===n&&o.symbol===k||o.symbol===_)||"PEPTIDE"===e&&"Branch"!==o.monomerType){const t={};r.rx.forEach((e=>{t[e]=o[e]})),i.set(o.symbol,t)}}return i}(e,n,s),a=new Map,h=yield i.functions.call("Chem:getRdKitModule"),c={value:null};if("RNA"===n){const t="RNA"===s?[k,_]:[L,_];for(const e of t)G(a,e,o,h,n,c)}for(let e=0;e<t.length;++e){const i=t[e];for(const t of i)if(""!==t)try{G(a,t,o,h,n,c)}catch(e){const n=l(e);throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n`+n),new Error(`Сan't get monomer '${t}' from library: ${n}`)}}return a}))}(f,n,d,m),g=u.length,y=new Array(g),b=new Array(0);for(let t=0;t<g;++t)try{const e=f[t];y[t]=X(e,p,m,d)}catch(e){const n=`Cannot get molfile of row #${t}: ${e instanceof Error?e.message:e.toString()}.`;b.push(n)}if(b.length>.05*g)throw new Error("Too many errors getting molfiles.");const w=`molfile(${u.name})`,v=t.columns.getUnusedName(w),C=s.Column.fromStrings(v,y);return C.semType=s.SEMTYPE.MOLECULE,C.setTag(s.TAGS.UNITS,s.UNITS.Molecule.MOLBLOCK),{col:C,warnings:b}}))}function G(t,e,n,i,s,r){if(!t.has(e)){const o=function(t,e,n,i,s){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const n of t){let t=n.capGroupSmiles;t||(t=n.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let n=t.indexOf(d,0),i=n;for(;-1!==n;){i=t.indexOf("\n",n);const s=parseInt(t.substring(n,i).replace(/^A\s+/,""));n=t.indexOf("R",i),i=t.indexOf("\n",n);const r=parseInt(t.substring(n,i).replace(/^R/,""));e.set(s,r),n=t.indexOf(d,i)}for(n=t.indexOf(m,0),i=t.indexOf("\n",n);-1!==n;){n+=u,i=t.indexOf("\n",n);const s=t.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<s.length;t+=2){if(e.has(s[t])&&e.get(s[t])!==s[t+1])throw new Error(`r-group index ${s[t]} has already been added with a different value`);e.set(s[t],s[t+1])}n=t.indexOf(m,i)}return e}(r.molfile),l=function(t,e){const n=e.get_mol(t),i=n.get_v3Kmolblock();return n.delete(),i}(function(t){let e=t.indexOf(d,0);-1===e&&(e=t.indexOf(m));const n=t.indexOf(A,e);return t.substring(0,e)+t.substring(n)}(r.molfile),n),h=function(t){let e=(t=t.replaceAll("\r","")).indexOf(v)+f,n=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,n));return e=n+1,n=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,n))}}(l),c=function(t,e){const n=new Array(e),i=new Float32Array(e),s=new Float32Array(e),r=new Array(e);let o=t.indexOf(S);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;l++){o=t.indexOf(N,o)+p,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),n[l]=t.substring(o,a);const e=new Array(2);for(let n=0;n<2;++n)o=a+1,a=t.indexOf(" ",o),e[n]=parseFloat(t.substring(o,a));i[l]=e[0],s[l]=e[1],o=a,a=t.indexOf("\n",o)+1,r[l]=t.slice(o,a),o=a}return{atomTypes:n,x:i,y:s,kwargs:r}}(l,h.atomCount),g=function(t,e){const n=new Uint32Array(e),i=new Array(e),s=new Map,r=new Map;let o=t.indexOf(T);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;++l){const e=new Array(3);o=t.indexOf(N,a)+p,a=t.indexOf(" ",o);for(let n=0;n<3;++n)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[n]=parseInt(t.slice(o,a));n[l]=e[0],i[l]=e.slice(1);const h=t.indexOf("\n",o);let c=t.slice(a,h),u=c.indexOf(E);if(-1!==u){u=c.indexOf("=",u)+1;let t=c.indexOf(" ",u);-1===t&&(t=c.length);const e=parseInt(c.slice(u,t));s.set(l,e);const n=E+e.toString();c=c.replace(n,"")}c||r.set(l,c)}return{bondTypes:n,atomPairs:i,bondConfiguration:s,kwargs:r}}(l,h.bondCount),y={atoms:c,bonds:g,meta:F(c,g,o,a)};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,s=t.atoms.y;z(t,-i[e],-s[e]);const r=D(i[n],s[n]);B(t.atoms,-r),i[t.meta.rNodes[1]-1]<0&&function(t){Y(t,!1)}(t);const o=function(t){const e=function(t){var e;const n=new Map;for(const i of t.bonds.atomPairs)for(let t=0;t<2;t++){const s=i[t],r=i[(t+1)%2];n.has(s)?null===(e=n.get(s))||void 0===e||e.push(r):n.set(s,new Array(1).fill(r))}return n}(t);let n=0,i=0;for(;0===n;){const s=e.get(t.meta.terminalNodes[1])[i];t.atoms.atomTypes[s-1]===R&&s!==t.meta.rNodes[1]&&(n=s),i++}return n}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){Y(t,!0)}(t),B(t.atoms,-function(t,e){return D(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const n=t.atoms.x;n[t.meta.rNodes[1]-1]>n[e-1]&&function(t,e,n){const i=e-1,s=n-1,r=t.atoms.x,o=t.atoms.y,a=r[i],l=o[i];r[i]=r[s],o[i]=o[s],r[s]=a,o[s]=l}(t,e,t.meta.rNodes[1])}(t,o)}(y):t===k||t===L?function(t,e){const n=t.atoms.x,i=t.atoms.y;let s=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;z(t,-n[s],-i[s]);const o=D(n[r],i[r]);B(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,n=t.atoms.y,i=t.meta.rNodes[2]-1,s=t.meta.terminalNodes[2]-1,r=e[i]-e[s],o=n[i]-n[s];return Math.atan(o/r)+Math.PI/2}(t),s=t.meta.terminalNodes[0]-1,z(t,-n[s],-i[s])}(y,s):t===_?function(t){const e=t.meta.terminalNodes[0]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,s=t.atoms.y;z(t,-i[e],-s[e]);const r=D(i[n],s[n]);B(t.atoms,Math.PI/2-r)}(y):function(t,e){const n=t.atoms.x,i=t.atoms.y,s=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;z(t,-n[s],-i[s]);const 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s=null!==(e=n.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")})))&&void 0!==e?e:null;return!s&&n.length>0&&(s=n[0]),s}},7767:(t,e,n)=>{"use strict";n.d(e,{L:()=>o});var i=n(976),s=n(499),r=n(585);class o extends s.C{get splitter(){return null===this._splitter&&(this._splitter=(0,r.Mj)(this.column)),this._splitter}toFasta(t){return"fasta"===t}toSeparator(t){return"separator"===t}toHelm(t){return"helm"===t}convertFastaToSeparator(t,e=null){null===e&&(e=this.defaultGapSymbol);const n=this.getNewColumn("separator",t);return n.init((n=>{const i=this.column.get(n),r=this.splitter(i);for(let t=0;t<r.length;t++)r[t]===e&&(r[t]=s.C._defaultGapSymbolsDict.SEPARATOR);return r.join(t)})),n.setTag(i.TAGS.UNITS,"separator"),n}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}convertToHelmHelper(t,e,n,i,r,o){return`${n}${this.splitter(t).map((t=>t&&t!==e?1==t.length?`${i}${t}${r}`:`${i}[${t}]${r}`:s.C._defaultGapSymbolsDict.HELM)).join(".")}${o}`}convertStringToHelm(t,e=null){null===e&&(e=this.defaultGapSymbol);const[n,i,s,r]=this.getHelmWrappers();return this.convertToHelmHelper(t,e,n,i,s,r)}convertToHelm(t=null){null===t&&(t=this.defaultGapSymbol);const[e,n,s,r]=this.getHelmWrappers(),o=this.getNewColumn("helm");return o.init((i=>{const o=this.column.get(i);return this.convertToHelmHelper(o,t,e,n,s,r)})),o.setTag(i.TAGS.UNITS,"helm"),o}convertSeparatorToFasta(t=null){null===t&&(t=s.C._defaultGapSymbolsDict.FASTA);const e=this.getNewColumn("fasta");return e.init((e=>{const n=this.column.get(e),i=this.splitter(n),s=[];for(let e=0;e<i.length;e++){const n=i[e];if(0===n.length)s.push(t);else if(n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join("")})),e.setTag(i.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?s.C._defaultGapSymbolsDict.FASTA:s.C._defaultGapSymbolsDict.SEPARATOR),n||(n=this.toFasta(e)?"":this.separator);const r=/(R\(|D\(|\)|P)/g,o=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let n=a[t];if(o&&(n=n.replace(r,"")),n===s.C._defaultGapSymbolsDict.HELM)l.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";l.push(t)}else l.push(n)}return l.join(n)}convertHelm(t,e,n){const i=this.getNewColumn(t,e);i.init((i=>{const s=this.column.get(i);return this.convertHelmToFastaSeparator(s,t,e,n)})),(0,r.Mj)(i);const s=this.stats.sameLength?"SEQ.MSA":"SEQ";return i.setTag("aligned",s),i}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,n)=>{"use strict";n.d(e,{C:()=>h});var i=n(976),s=n(1821),r=n(585),o=n(489),a=n(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}};class h{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||"fasta"!==t.column.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'fasta' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,"fasta"),h.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||"separator"!==t.column.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'separator' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error("The column of notation 'separator' must have the separator tag.");t.column.setTag(i.TAGS.UNITS,"separator"),t.column.setTag("separator",e),h.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation 'helm' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,"helm"),h.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),n=t.stats;if(Object.keys(n.freq).some((t=>t.length>1)),["fasta","separator"].includes(e)){if(0===Object.keys(n.freq).length)throw new Error("Alphabet is empty");const e=n.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const i=(0,r.w4)(n.freq,s.XS);if(t.column.setTag("alphabet",i),"UN"===i){const e=Object.keys(n.freq).length,i=Object.keys(n.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){var t;const e=null!==(t=this.column.getTag("separator"))&&void 0!==t?t:void 0;if("separator"===this.notation&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return"helm"===this.notation||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const n=this._column.getRawData(),i=this._column.categories;for(let s=0;s<e;s++){const e=i[n[s]];this._splitted[s]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,n=null;for(const i of this.splitted){null==n?n=i.length:i.length!==n&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t,e){const n=this.column,s=n.length,r=t.toLowerCase()+"("+n.name+")",o=n.dataFrame.columns.getUnusedName(r),a=i.Column.fromList("string",o,new Array(s).fill(""));if(a.semType=i.SEMTYPE.MACROMOLECULE,a.setTag(i.TAGS.UNITS,t),"separator"===t){if(!e)throw new Error("Notation 'separator' requires separator value.");a.setTag("separator",e)}a.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const l=n.getTag("aligned");l&&a.setTag("aligned",l);const h=n.getTag("alphabet");h&&a.setTag("alphabet",h);let c=n.getTag(".alphabetSize");c&&a.setTag(".alphabetSize",c);const u=n.getTag(".alphabetIsMultichar");return void 0!==u&&a.setTag(".alphabetIsMultichar",u),"helm"==t&&(c=this.getAlphabetSize().toString(),a.setTag(".alphabetSize",c)),a}static getNewColumn(t){const e=h.getOrCreate(t),n=e.notation;return e.getNewColumn(n)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!h.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const s=i.Column.fromList("string",e,new Array(t).fill(""));return s.semType=i.SEMTYPE.MACROMOLECULE,s.setTag(i.TAGS.UNITS,n),s}getSplitter(){return(0,r.Mj)(this._column)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}checkHelmCompatibility(){return t=this,e=void 0,i=function*(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(yield(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),n=(0,r.Ar)(this.separator);for(const t of this.column.categories){const i=n(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0},new((n=void 0)||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}));var t,e,n,i}constructor(t){this._splitted=null,this._stats=null,this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h._defaultGapSymbolsDict.FASTA:this.isHelm()?h._defaultGapSymbolsDict.HELM:h._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())h.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");h.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);h.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new h(t)),t.temp[l.uhTemp]}}h._defaultGapSymbolsDict={HELM:"*",SEPARATOR:"",FASTA:"-"}},9298:(t,e,n)=>{"use strict";var 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n=t.toString();if(n.length<=e)return n;let i=t.toFixed(e);if(i.length>e&&(i=t.toFixed(Math.max(0,e-(i.length-e)))),i.length<=e&&!i.startsWith("0.000")&&!i.startsWith("-0.000"))return i;let s=t.toExponential(e);return s.length>e&&(s=t.toExponential(Math.max(0,e-(s.length-e)))),s.slice(0)}function b(t,e,n){let i=n?t.rows:t.rows-1;if(e<0||e>i)throw new RangeError("Row index out of range")}function w(t,e,n){let i=n?t.columns:t.columns-1;if(e<0||e>i)throw new RangeError("Column index out of range")}function v(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.columns)throw new RangeError("vector size must be the same as the number of columns");return e}function C(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.rows)throw new RangeError("vector size must be the same as the number of rows");return e}function S(t,e,n,i,s){if(5!==arguments.length)throw new RangeError("expected 4 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s=t.get(i,n)/t.get(e,n);t.set(i,n,0);for(let r=n+1;r<t.columns;r++)t.set(i,r,t.get(i,r)-t.get(e,r)*s)}e++,n++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,n=t.rows,i=n-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let s=0,r=!1;for(;s<n&&!1===r;)1===t.get(i,s)?r=!0:s++;for(let n=0;n<i;n++){let r=t.get(n,s);for(let o=s;o<e;o++){let e=t.get(n,o)-r*t.get(i,o);t.set(n,o,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:n=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(n)||n<=0)throw new TypeError("columns must be a positive integer");let i=new A(this.rows*e,this.columns*n);for(let t=0;t<e;t++)for(let e=0;e<n;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,t);return this}neg(){return this.mulS(-1)}getRow(t){b(this,t);let e=[];for(let n=0;n<this.columns;n++)e.push(this.get(t,n));return e}getRowVector(t){return A.rowVector(this.getRow(t))}setRow(t,e){b(this,t),e=v(this,e);for(let n=0;n<this.columns;n++)this.set(t,n,e[n]);return this}swapRows(t,e){b(this,t),b(this,e);for(let n=0;n<this.columns;n++){let i=this.get(t,n);this.set(t,n,this.get(e,n)),this.set(e,n,i)}return this}getColumn(t){w(this,t);let e=[];for(let n=0;n<this.rows;n++)e.push(this.get(n,t));return e}getColumnVector(t){return A.columnVector(this.getColumn(t))}setColumn(t,e){w(this,t),e=C(this,e);for(let n=0;n<this.rows;n++)this.set(n,t,e[n]);return this}swapColumns(t,e){w(this,t),w(this,e);for(let n=0;n<this.rows;n++){let i=this.get(n,t);this.set(n,t,this.get(n,e)),this.set(n,e,i)}return this}addRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t[n]);return 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Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[e]&&(t[e]=this.get(e,n));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[n]&&(t[n]=this.get(e,n));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t&&(t=this.get(e,n));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){x(this);let t=this.get(0,0),e=[0,0];for(let n=0;n<this.rows;n++)for(let i=0;i<this.columns;i++)this.get(n,i)<t&&(t=this.get(n,i),e[0]=n,e[1]=i);return e}maxRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n));return e}maxRowIndex(t){b(this,t),x(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),n[1]=i);return n}minRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n));return e}minRowIndex(t){b(this,t),x(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),n[1]=i);return n}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t));return e}maxColumnIndex(t){w(this,t),x(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),n[0]=i);return n}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t));return e}minColumnIndex(t){w(this,t),x(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),n[0]=i);return n}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let n=0;n<t;n++)e.push(this.get(n,n));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let n=0;n<this.columns;n++)e+=this.get(t,n)*this.get(t,n);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t+=this.get(e,n),this.set(e,n,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}mmul(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.columns,s=new A(e,i),r=new Float64Array(n);for(let o=0;o<i;o++){for(let e=0;e<n;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let i=0;i<n;i++)e+=this.get(t,i)*r[i];s.set(t,o,e)}}return s}strassen2x2(t){t=A.checkMatrix(t);let e=new A(2,2);const n=this.get(0,0),i=t.get(0,0),s=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(n+l)*(i+h),u=(o+l)*i,m=n*(r-h),d=l*(a-i),f=(n+s)*h,p=c+d-f+(s-l)*(a+h),g=m+f,y=u+d,b=c-u+m+(o-n)*(i+r);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,y),e.set(1,1,b),e}strassen3x3(t){t=A.checkMatrix(t);let e=new A(3,3);const n=this.get(0,0),i=this.get(0,1),s=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),f=t.get(1,0),p=t.get(1,1),g=t.get(1,2),y=t.get(2,0),b=t.get(2,1),w=t.get(2,2),v=(n-r)*(-m+p),C=(-n+r+o)*(u-m+p),S=(r+o)*(-u+m),M=n*u,T=(-n+l+h)*(u-d+g),x=(-n+l)*(d-g),E=(l+h)*(-u+d),N=(-s+h+c)*(p+y-b),I=(s-c)*(p-b),L=s*y,k=(h+c)*(-y+b),_=(-s+o+a)*(g+y-w),R=(s-a)*(g-w),O=(o+a)*(-y+w),P=M+L+i*f,G=(n+i+s-r-o-h-c)*p+C+S+M+N+L+k,F=M+T+E+(n+i+s-o-a-l-h)*g+L+_+O,W=v+o*(-u+m+f-p-g-y+w)+C+M+L+_+R,V=v+C+S+M+a*b,H=L+_+R+O+r*d,Z=M+T+x+h*(-u+d+f-p-g-y+b)+N+I+L,U=N+I+L+k+l*m,D=M+T+x+E+c*w;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,Z),e.set(2,1,U),e.set(2,2,D),e}mmulStrassen(t){t=A.checkMatrix(t);let e=this.clone(),n=e.rows,i=e.columns,s=t.rows,r=t.columns;function o(t,e,n){let i=t.rows,s=t.columns;if(i===e&&s===n)return t;{let i=E.zeros(e,n);return i=i.setSubMatrix(t,0,0),i}}i!==s&&console.warn(`Multiplying ${n} x ${i} and ${s} x ${r} matrix: dimensions do not match.`);let a=Math.max(n,s),l=Math.max(i,r);return e=o(e,a,l),function t(e,n,i,s){if(i<=512||s<=512)return e.mmul(n);i%2==1&&s%2==1?(e=o(e,i+1,s+1),n=o(n,i+1,s+1)):i%2==1?(e=o(e,i+1,s),n=o(n,i+1,s)):s%2==1&&(e=o(e,i,s+1),n=o(n,i,s+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=n.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=n.subMatrix(0,r-1,a,n.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=n.subMatrix(r,n.rows-1,0,a-1),f=e.subMatrix(r,e.rows-1,a,e.columns-1),p=n.subMatrix(r,n.rows-1,a,n.columns-1),g=t(E.add(l,f),E.add(h,p),r,a),y=t(E.add(m,f),h,r,a),b=t(l,E.sub(u,p),r,a),w=t(f,E.sub(d,h),r,a),v=t(E.add(l,c),p,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,f),E.add(d,p),r,a),M=E.add(g,w);M.sub(v),M.add(S);let T=E.add(b,v),x=E.add(y,w),N=E.sub(g,y);N.add(b),N.add(C);let A=E.zeros(2*M.rows,2*M.columns);return A=A.setSubMatrix(M,0,0),A=A.setSubMatrix(T,M.rows,0),A=A.setSubMatrix(x,0,M.columns),A=A.setSubMatrix(N,M.rows,M.columns),A.subMatrix(0,i-1,0,s-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.rows;t++){const s=this.getRow(t);s.length>0&&m(s,{min:e,max:n,output:s}),i.setRow(t,s)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.columns;t++){const s=this.getColumn(t);s.length&&m(s,{min:e,max:n,output:s}),i.setColumn(t,s)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let n=0;n<t;n++){let t=this.get(e,n),i=this.get(e,this.columns-1-n);this.set(e,n,i),this.set(e,this.columns-1-n,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let n=0;n<t;n++){let t=this.get(n,e),i=this.get(this.rows-1-n,e);this.set(n,e,i),this.set(this.rows-1-n,e,t)}return this}kroneckerProduct(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.rows,s=t.columns,r=new A(e*i,n*s);for(let o=0;o<e;o++)for(let e=0;e<n;e++)for(let n=0;n<i;n++)for(let a=0;a<s;a++)r.set(i*o+n,s*e+a,this.get(o,e)*t.get(n,a));return r}kroneckerSum(t){if(t=A.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,n=t.rows,i=this.kroneckerProduct(A.eye(n,n)),s=A.eye(e,e).kroneckerProduct(t);return i.add(s)}transpose(){let t=new A(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(n,e,this.get(e,n));return t}sortRows(t=N){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=N){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,n,i){S(this,t,e,n,i);let s=new A(e-t+1,i-n+1);for(let r=t;r<=e;r++)for(let e=n;e<=i;e++)s.set(r-t,e-n,this.get(r,e));return s}subMatrixRow(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.columns-1),e>n||e<0||e>=this.columns||n<0||n>=this.columns)throw new RangeError("Argument out of range");let i=new A(t.length,n-e+1);for(let s=0;s<t.length;s++)for(let r=e;r<=n;r++){if(t[s]<0||t[s]>=this.rows)throw new RangeError(`Row index out of range: ${t[s]}`);i.set(s,r-e,this.get(t[s],r))}return i}subMatrixColumn(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.rows-1),e>n||e<0||e>=this.rows||n<0||n>=this.rows)throw new RangeError("Argument out of range");let i=new A(n-e+1,t.length);for(let s=0;s<t.length;s++)for(let r=e;r<=n;r++){if(t[s]<0||t[s]>=this.columns)throw new RangeError(`Column index out of range: ${t[s]}`);i.set(r-e,s,this.get(r,t[s]))}return i}setSubMatrix(t,e,n){if((t=A.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,n,n+t.columns-1);for(let i=0;i<t.rows;i++)for(let s=0;s<t.columns;s++)this.set(e+i,n+s,t.get(i,s));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let n=new A(t.length,e.length);for(let i=0;i<t.length;i++){let s=t[i];for(let t=0;t<e.length;t++){let r=e[t];n.set(i,t,this.get(s,r))}}return n}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let n=0;n<t;n++)e+=this.get(n,n);return e}clone(){let t=new A(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(e,n,this.get(e,n));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]+=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]+=t.get(n,i);return e}(this);case void 0:return function(t){let e=0;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e+=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]*=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]*=t.get(n,i);return e}(this);case void 0:return function(t){let e=1;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e*=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:n=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof n)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<s;e++)l=t.get(o,e)-n[o],i+=l,a+=l*l;e?r.push((a-i*i/s)/(s-1)):r.push((a-i*i/s)/s)}return r}(this,n,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,r=[];for(let o=0;o<s;o++){let s=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,o)-n[o],s+=l,a+=l*l;e?r.push((a-s*s/i)/(i-1)):r.push((a-s*s/i)/i)}return r}(this,n,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,n){const i=t.rows,s=t.columns,r=i*s;let o=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<s;i++)l=t.get(e,i)-n,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,n,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const n=this.variance(t,e);if(void 0===t)return Math.sqrt(n);for(let t=0;t<n.length;t++)n[t]=Math.sqrt(n[t]);return n}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:n=this.mean(t)}=e;switch(t){case"row":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[n])}(this,n),this;case"column":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[i])}(this,n),this;case void 0:if("number"!=typeof n)throw new TypeError("center must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let n=e.scale;switch(t){case"row":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.rows;n++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(n,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[n])}(this,n),this;case"column":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.columns;n++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,n),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[i])}(this,n),this;case void 0:if(void 0===n)n=function(t){const e=t.size-1;let n=0;for(let i=0;i<t.columns;i++)for(let s=0;s<t.rows;s++)n+=Math.pow(t.get(s,i),2)/e;return Math.sqrt(n)}(this);else if("number"!=typeof n)throw new TypeError("scale must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function N(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class A extends E{constructor(t,e){if(super(),A.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let n=0;n<t;n++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const n=t;if("number"!=typeof(e=(t=n.length)?n[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(n[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!n[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(n[i]))}}}this.rows=t,this.columns=e}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}removeRow(t){return b(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),b(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const n=new Float64Array(this.columns-1);for(let i=0;i<t;i++)n[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)n[i-1]=this.data[e][i];this.data[e]=n}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=C(this,e);for(let n=0;n<this.rows;n++){const i=new Float64Array(this.columns+1);let s=0;for(;s<t;s++)i[s]=this.data[n][s];for(i[s++]=e[n];s<this.columns+1;s++)i[s]=this.data[n][s-1];this.data[n]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t.get(e,n));return this},t.add=function(t,n){return new e(t).add(n)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t.get(e,n));return this},t.sub=function(t,n){return new e(t).sub(n)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t.get(e,n));return this},t.mul=function(t,n){return new e(t).mul(n)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t.get(e,n));return this},t.div=function(t,n){return new e(t).div(n)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t.get(e,n));return this},t.mod=function(t,n){return new e(t).mod(n)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t.get(e,n));return this},t.and=function(t,n){return new e(t).and(n)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t.get(e,n));return this},t.or=function(t,n){return new e(t).or(n)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t.get(e,n));return this},t.xor=function(t,n){return new e(t).xor(n)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t.get(e,n));return this},t.leftShift=function(t,n){return new e(t).leftShift(n)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t.get(e,n));return this},t.signPropagatingRightShift=function(t,n){return new e(t).signPropagatingRightShift(n)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t.get(e,n));return this},t.rightShift=function(t,n){return new e(t).rightShift(n)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,n){return new e(t).pow(n)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t.get(e,n)));return this}}(E,A);class I extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,n,i,s,r,o,a,l,h,c=(t=I.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),f=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),n=0;n<m;n++){for(e=0;e<u;e++)l[e]=c.get(e,n);for(e=0;e<u;e++){for(h=Math.min(e,n),r=0,i=0;i<h;i++)r+=c.get(e,i)*l[i];l[e]-=r,c.set(e,n,l[e])}for(s=n,e=n+1;e<u;e++)Math.abs(l[e])>Math.abs(l[s])&&(s=e);if(s!==n){for(i=0;i<m;i++)o=c.get(s,i),c.set(s,i,c.get(n,i)),c.set(n,i,o);a=d[s],d[s]=d[n],d[n]=a,f=-f}if(n<u&&0!==c.get(n,n))for(e=n+1;e<u;e++)c.set(e,n,c.get(e,n)/c.get(n,n))}this.LU=c,this.pivotVector=d,this.pivotSign=f}isSingular(){let t=this.LU,e=t.columns;for(let n=0;n<e;n++)if(0===t.get(n,n))return!0;return!1}solve(t){t=A.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let n,i,s,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(s=0;s<a;s++)for(n=s+1;n<a;n++)for(i=0;i<r;i++)o.set(n,i,o.get(n,i)-o.get(s,i)*e.get(n,s));for(s=a-1;s>=0;s--){for(i=0;i<r;i++)o.set(s,i,o.get(s,i)/e.get(s,s));for(n=0;n<s;n++)for(i=0;i<r;i++)o.set(n,i,o.get(n,i)-o.get(s,i)*e.get(n,s))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,n=t.columns;for(let i=0;i<n;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s>e?i.set(s,e,t.get(s,e)):s===e?i.set(s,e,1):i.set(s,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s<=e?i.set(s,e,t.get(s,e)):i.set(s,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function k(t,e){let n=0;return Math.abs(t)>Math.abs(e)?(n=e/t,Math.abs(t)*Math.sqrt(1+n*n)):0!==e?(n=t/e,Math.abs(e)*Math.sqrt(1+n*n)):0}class _{constructor(t){let e,n,i,s,r=(t=I.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<o;e++)t=k(t,r.get(e,i));if(0!==t){for(r.get(i,i)<0&&(t=-t),e=i;e<o;e++)r.set(e,i,r.get(e,i)/t);for(r.set(i,i,r.get(i,i)+1),n=i+1;n<a;n++){for(s=0,e=i;e<o;e++)s+=r.get(e,i)*r.get(e,n);for(s=-s/r.get(i,i),e=i;e<o;e++)r.set(e,n,r.get(e,n)+s*r.get(e,i))}}l[i]=-t}this.QR=r,this.Rdiag=l}solve(t){t=A.checkMatrix(t);let e=this.QR,n=e.rows;if(t.rows!==n)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,s,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(s=0;s<a;s++){for(o=0,i=r;i<n;i++)o+=e.get(i,r)*l.get(i,s);for(o=-o/e.get(r,r),i=r;i<n;i++)l.set(i,s,l.get(i,s)+o*e.get(i,r))}for(r=h-1;r>=0;r--){for(s=0;s<a;s++)l.set(r,s,l.get(r,s)/this.Rdiag[r]);for(i=0;i<r;i++)for(s=0;s<a;s++)l.set(i,s,l.get(i,s)-l.get(r,s)*e.get(i,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,n=this.QR,i=n.columns,s=new A(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?s.set(t,e,n.get(t,e)):t===e?s.set(t,e,this.Rdiag[t]):s.set(t,e,0);return s}get orthogonalMatrix(){let t,e,n,i,s=this.QR,r=s.rows,o=s.columns,a=new A(r,o);for(n=o-1;n>=0;n--){for(t=0;t<r;t++)a.set(t,n,0);for(a.set(n,n,1),e=n;e<o;e++)if(0!==s.get(n,n)){for(i=0,t=n;t<r;t++)i+=s.get(t,n)*a.get(t,e);for(i=-i/s.get(n,n),t=n;t<r;t++)a.set(t,e,a.get(t,e)+i*s.get(t,n))}}return a}}class R{constructor(t,e={}){if((t=I.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let n=t.rows,i=t.columns;const{computeLeftSingularVectors:s=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(s),h=Boolean(r),c=!1;if(n<i)if(o){a=t.transpose(),n=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(n,i),m=Math.min(n+1,i),d=new Float64Array(m),f=new A(n,u),p=new A(i,i),g=new Float64Array(i),y=new Float64Array(n),b=new Float64Array(m);for(let t=0;t<m;t++)b[t]=t;let w=Math.min(n-1,i),v=Math.max(0,Math.min(i-2,n)),C=Math.max(w,v);for(let t=0;t<C;t++){if(t<w){d[t]=0;for(let e=t;e<n;e++)d[t]=k(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<n;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<i;e++){if(t<w&&0!==d[t]){let i=0;for(let s=t;s<n;s++)i+=a.get(s,t)*a.get(s,e);i=-i/a.get(t,t);for(let s=t;s<n;s++)a.set(s,e,a.get(s,e)+i*a.get(s,t))}g[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<n;e++)f.set(e,t,a.get(e,t));if(t<v){g[t]=0;for(let e=t+1;e<i;e++)g[t]=k(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<n&&0!==g[t]){for(let e=t+1;e<n;e++)y[e]=0;for(let e=t+1;e<n;e++)for(let n=t+1;n<i;n++)y[e]+=g[n]*a.get(e,n);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let s=t+1;s<n;s++)a.set(s,e,a.get(s,e)+i*y[s])}}if(h)for(let e=t+1;e<i;e++)p.set(e,t,g[e])}}let S=Math.min(i,n+1);if(w<i&&(d[w]=a.get(w,w)),n<S&&(d[S-1]=0),v+1<S&&(g[v]=a.get(v,S-1)),g[S-1]=0,l){for(let t=w;t<u;t++){for(let e=0;e<n;e++)f.set(e,t,0);f.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let i=0;for(let s=t;s<n;s++)i+=f.get(s,t)*f.get(s,e);i=-i/f.get(t,t);for(let s=t;s<n;s++)f.set(s,e,f.get(s,e)+i*f.get(s,t))}for(let e=t;e<n;e++)f.set(e,t,-f.get(e,t));f.set(t,t,1+f.get(t,t));for(let e=0;e<t-1;e++)f.set(e,t,0)}else{for(let e=0;e<n;e++)f.set(e,t,0);f.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<v&&0!==g[t])for(let e=t+1;e<i;e++){let n=0;for(let s=t+1;s<i;s++)n+=p.get(s,t)*p.get(s,e);n=-n/p.get(t+1,t);for(let s=t+1;s<i;s++)p.set(s,e,p.get(s,e)+n*p.get(s,t))}for(let e=0;e<i;e++)p.set(e,t,0);p.set(t,t,1)}let M=S-1,T=0,x=Number.EPSILON;for(;S>0;){let 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i=n(4469),s=n(3870),r=n(976);const o=n(585).GU;var a;!function(t){t.MSA="MSA",t.classic="classic"}(a||(a={}));const l=(t,e,n,i,s,r,l="rgb(100,100,100)",h=0,c=!1,u=1,m="",d=!1,f=a.classic,p={},g=0,y=null,b=[],w=null)=>{var v,C,S;s.textAlign="start";let M=r.substring(0),T=d?"":m;f===a.MSA&&(T="");let x=!0,E=!0,N="difference";null!=y&&null!=y.cell.column&&(x=null===(v=y.cell.column.temp["color-code"])||void 0===v||v,E=null===(C=y.cell.column.temp["compare-with-current"])||void 0===C||C,N=null!==(S=y.cell.column.temp["highlight-difference"])&&void 0!==S?S:"difference");const A=b[g];E&&b.length>0&&"difference"===N&&(u=M==A?.3:u),E&&b.length>0&&"equal"===N&&(u=M!=A?.3:u),null!=w&&(M=o(M,w));let I=s.measureText(M+T),L=s.measureText(M).width,k=s.measureText(M).width;const _=i/2-(I.fontBoundingBoxAscent+I.fontBoundingBoxDescent)/2+1;function R(n,i){const r=x?l:"rgb(0,0,0)";s.fillStyle=r,s.globalAlpha=u,f===a.classic&&(s.fillText(M,t+n,e+_),s.fillStyle="#808080",s.fillText(T,t+i,e+_)),f===a.MSA&&(s.fillStyle=r,s.fillText(M,t+n+(p[g]-k)/2,e+_))}if(I=I.width,f===a.MSA&&(L=p[g],I=p[g]),c||I>n)return R(5,5+L),t+L+s.measureText(T).width;{const e=(n-I)/2;return R(e,e+L),t+e+L}};var h=n(8447),c=n(7331),u=n(3553);const m="rgb(100,100,100)",d=h.GU;function f(t,e,n,i){return t?Math.min(t.canvas.width-n,i):e.canvas.width-n}function p(t){const e=!t.some(((e,n)=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";return t.forEach(((e,s)=>{s<t.length&&(e+=`${e?"":"-"}${i}`),n.push(e)})),[n,e]}class g extends r.GridCellRenderer{get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){if("SEQ.MSA"!==t.cell.column.getTag("aligned"))return;const n=t.cell.column.temp,i=n["bio-sum-maxLengthWords"],r=n["bio-maxIndex"],o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-t.bounds.x);let a=0,l=r,c=!1;i[r+1]=o+1;let u=0;if(o>i[0])for(;!c;)u=Math.floor((l+a)/2),o>=i[u]&&o<=i[u+1]?(a=u,c=!0):o<i[u]?l=u-1:o>i[u+1]&&(a=u+1),a==l&&(c=!0);a=o>=i[a]?a+1:a;const m=t.cell.column.getTag("separator")??"",d=(0,h.vU)("separator",m)(t.cell.value);(d[a]?.length??0)>0?s.tooltip.show(s.div(d[a]),e.x+16,e.y+16):s.tooltip.hide()}render(t,e,n,i,s,o,c){const u=-1!==o.gridRow?o.grid:null,p=o.cell,g=o.cell.column.getTag("alphabet");i=f(u,t,e,i),t.save(),t.beginPath(),t.rect(e,n,i,s),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=o.cell.column.getTag(r.TAGS.UNITS),b=o.cell.column.getTag("aligned"),w=(0,h.py)(g),v=o.cell.column.getTag("separator")??"",C=i/5,S=(0,h.vU)(y,v,C),M=o.cell.column.temp,T=M["reference-sequence"],x=M["current-word"],E=M["monomer-width"],N=S(null!=T&&""!=T?T:x??"");let A=5,I=0,L=8;"short"===(null!=E?E:"short")&&(A=12,L=1);let k={};if(o.cell.column.getTag(".calculatedCellRender")!==C.toString()){let t=0;for(;t<Math.min(o.cell.column.length,100);)S(o.cell.column.get(t)).forEach(((t,e)=>{const n=7*d(t,L).length+A;n>(k[e]??0)&&(k[e]=n),e>I&&(I=e)})),t+=1;const e=21;for(let t=0;t<=I;t++){k[t]<e&&(k[t]=e);const n={};n[0]=k[0];for(let t=1;t<=I;t++)n[t]=n[t-1]+k[t];M["bio-sum-maxLengthWords"]=n,M["bio-maxIndex"]=I,M["bio-maxLengthWords"]=k,o.cell.column.setTag(".calculatedCellRender",C.toString())}}else k=M["bio-maxLengthWords"];const _=S(p.value);let R=e,O=m,P=a.classic;b&&b.includes("MSA")&&"separator"==y&&(P=a.MSA),_.every(((e,r)=>{O=w.get(e),t.fillStyle=m;const a=r===_.length-1;return R=l(R,n,i,s,t,e,O,0,!0,1,v,a,P,k,r,o,N,L),50<=i})),t.restore()}}class y extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return u.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,s,o,a){const l=o.grid,c=o.cell.value??"",u=o.tableColumn.tags.separator,m=o.tableColumn.tags[r.TAGS.UNITS];i=f(l,t,e,i);const[d,p]=c.split("#"),g=(0,h.vU)(m,u);b(t,e,n,i,s,g(d),g(p),m)}}function b(t,e,n,i,s,r,o,a,u,m){if(r.length!==o.length){const t=function(t,e){let n=0,i=0;const s=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)s[t]===r[t]&&n++;const o=s.length-r.length;for(let t=s.length-1;t>o;t--)s[t]===r[t-o]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(r,o);r=t.subParts1,o=t.subParts2}const d=t.measureText(p(r).join("")),f=t.measureText(p(o).join("")),g=Math.max(d.width,f.width);u&&(i=g+4*r.length,t.canvas.width=g+4*r.length);let y=Math.max(e,e+(i-(g+4*r.length))/2);const b=Math.max(n,n+(s-28)/2);t.save(),t.beginPath(),t.rect(e,n,u?g+4*r.length:i,s),t.clip(),t.font="12px monospace",t.textBaseline="top";let v=c.UE.Color;"HELM"!=a&&(v=(0,h.py)(a.substring(a.length-2)));for(let e=0;e<r.length;e++){const n=r[e],a=o[e],h=v.get(n);if(n!=a){const r=v.get(a),o=l(y,b-7,i,s,t,n,h,0,!0),c=l(y,b+7,i,s,t,a,r,0,!0);y=Math.max(c,o),m&&(m[e]=w(n,a,h,r,b,7,s))}else y=l(y,b,i,s,t,n,h,0,!0,.5);y+=4}t.restore()}function w(t,e,n,i,s,r,o){const a=document.createElement("canvas"),h=a.getContext("2d");h.font="12px monospace";const c=h.measureText(p([t]).join("")).width,u=h.measureText(p([e]).join("")).width,m=Math.max(c,u);return a.height=o,a.width=m+4,h.font="12px monospace",h.textBaseline="top",l(0,s-r,m,o,h,t,n,0,!0),l(0,s+r,m,o,h,e,i,0,!0),a}var v,C=n(701),S=n(2121),M=n(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(v||(v={})),new class{constructor(){this.regionTypes=[v.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=M.ES.Entropy}};const T=v;class x extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.regionTypes=this.stringList("regionTypes",[T.CDR],{choices:Object.values(T).filter((t=>t!=T.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16),this.positionHeight=this.string("positionHeight",M.ES.Entropy,{choices:Object.keys(M.ES)})}async init(){this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.subs.push(C.fromEvent(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}async onTableAttached(){const t=super.onTableAttached.bind(this);this.viewPromise=this.viewPromise.then((async()=>{t(),this.viewed||(await this.buildView("onTableAttached"),this.viewed=!0)}))}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){console.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})),this.regions=e,this.dataFrame=t,this.viewPromise=this.viewPromise.then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)}))}detach(){const t=super.detach.bind(this);this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}async destroyView(t){console.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){console.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort();this.logos=[];for(let t=0;t<n.length;t++){const i={};for(const s of this.chains){const r=e.find((e=>e.order==n[t]&&e.chain==s));i[s]=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight})}this.logos[t]=i}this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",s.tooltip.bind(this.filterSourceInput.root,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),console.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){const t=(this.root.clientHeight-54)/this.chains.length,e=Math.min(t,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));for(let t=0;t<this.logos.length;t++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[t][i].root.style.height=`${e}px`}}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?M.Ct.Selected:M.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[e][i].setOptions({[S.bo.filterSource]:t})}}}var E=n(9017),N=n(850);async function A(t,e,i,s,r){const o=await async function(t,e,i,s){return new Promise((function(r,o){const a=new Worker(new URL(n.p+n.u(729),n.b));a.postMessage({columnData:t.data,method:e,measure:t.metric,options:i,parallelDistanceWorkers:s}),a.onmessage=({data:{error:t,distance:e,embedding:n}})=>{t?o(t):r({distance:e,embedding:n}),setTimeout((()=>a.terminate()),0)}}))}({data:t,metric:i},e,s,r);return o.embedding=o.embedding.map((t=>(0,N.Fv)(t))),o}var I=n(7983),L=n(499),k=n(7767),_=n(489);async function R(t){const e=new k.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let n=_.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert("fasta");i=t.toList(),n=L.C.getOrCreate(t).getDistanceFunctionName()}else n=e.getDistanceFunctionName();for(let e=0;e<i.length;e++)i[e]=t.seqCol.isNone(e)?null:i[e];const s=await A(i,t.methodName,n,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,s.embedding[e])));return{distance:s.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,I.HV)(t.seqCol,!1),await i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function O(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}var P=n(5697),G=n(3379),F=n.n(G),W=n(7795),V=n.n(W),H=n(569),Z=n.n(H),U=n(3565),D=n.n(U),B=n(9216),Y=n.n(B),z=n(4589),X=n.n(z),q=n(9414),K={};K.styleTagTransform=X(),K.setAttributes=D(),K.insert=Z().bind(null,"head"),K.domAPI=V(),K.insertStyleElement=Y(),F()(q.Z,K),q.Z&&q.Z.locals&&q.Z.locals;var j=n(3914),$=n(6254);let J=0;const Q="cliffsDf",tt=new C.Subject,et="act_diff",nt="sali",it="sim",st="line_index",rt=["1_seq","2_seq"],ot="filterCliffs";function at(t,e,n){const i=e.getBoundingClientRect(),s=t.clientX-i.left,r=t.clientY-i.top;let o=null,a=0;for(const t of n){const e=Math.abs(Math.hypot(t.a[0]-s,t.a[1]-r)+Math.hypot(t.b[0]-s,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var lt=n(1040);async function ht(t,e,n,s,o){e.version!==e.temp["last-invalidated-version"]&&await(0,I.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(s).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:s,simArr:o})}function ct(t){const e=s.divH([]),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.line.mols.forEach(((n,i)=>{const r=s.divText(t.activityCol.get(n).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),r]))})),e}function ut(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2),i=new Array(2);t.line.mols.forEach(((e,s)=>{n[s]=t.seqCol.get(e),i[s]=t.activityCol.get(e)}));const o={},a=t.seqCol.getTag(r.TAGS.UNITS),l=t.seqCol.getTag("separator"),c=(0,h.vU)(a,l),u=dt(c(n[0]),c(n[1]),a,o);return e.append(s.div(u,{style:{width:"300px",overflow:"scroll"}})),e.append(ft(o)),e.append(mt("Activity delta",Math.abs(i[0]-i[1]))),e.append(mt("Cliff",t.sali)),e}function mt(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function dt(t,e,n,i){const s=document.createElement("canvas"),r=s.getContext("2d");return s.height=30,b(r,0,0,0,30,t,e,n,!0,i),s}function ft(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function pt(t,e){const n=r.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),n.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}n(7861);var gt=n(4004),yt=n(7228),bt=n(1731),wt=n(5226);n(9133);class vt extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",P.kg[0],{choices:P.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(s.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Ct=n(7241),St=n(4293),Mt=n(2669);async function Tt(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=L.C.getOrCreate(t).getDistanceFunctionName(),i=new Mt.m(!0,!1),s=await i.calc(e,n);return i.terminate(),s}function xt(t){return(e,n)=>{const i=(e,n)=>t*e+n-Math.floor((e+2)*(e+1)/2);return e<=n?i(e,n):i(n,e)}}class Et extends vt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new C.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=L.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const s=n.plot.grid();s.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));s.cell("score",o).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,St.Y)(this.root,s.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ct.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Tt(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=L.C.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(n.p+n.u(190),n.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,n)=>{const r=Math.floor(n*i.length/o),u=n===a.length-1?Math.floor((n+1)*i.length/o):i.length;return new Promise(((n,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:s}})=>{t?o(t):(h=Math.min(h,i),c=Math.max(c,s),l.set(e,r),n())},t.postMessage({fnName:s,values:i,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=xt(e),s=Array(e).fill(0).map(((e,n)=>({idx:n,score:n===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,n)]:1-t[n]})));s.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=s.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=s.div(),n={},o=this.molCol?.name,a=t.col(o).getTag(r.TAGS.UNITS),l=t.col(o).getTag("separator"),c=(0,h.vU)(a,l),u=c(this.moleculeColumn.get(this.targetMoleculeIdx)),m=c(t.get(o,t.currentRowIdx)),d=dt(u,m,a,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),u.length!==m.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${u.length} monomers`),s.divText(`selected: ${m.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(ft(n));const f=s.accordion(),p=s.element("i");p.className="grok-icon svg-icon svg-view-layout",f.addTitle(s.span([p,s.label("Similarity search")])),f.addPane("Differences",(()=>e),!0),i.shell.o=f.root}}var Nt=n(8518);class At extends vt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new C.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=L.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));n.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>n.setTag(t,this.moleculeColumn.getTag(t))));const i=r.DataFrame.fromColumns([n]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,St.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ct.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Tt(this.moleculeColumn),e=this.moleculeColumn.length,n=xt(e);this.renderMolIds=(0,Nt.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[n(e,i)]))}}var It=n(9943),Lt=n(4413),kt=n(1061),_t=n(1345),Rt=n(116);const Ot={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Pt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}constructor(t){this.methodSettingsDiv=s.inputs([]),this.methodsParams={[Rt.AL.UMAP]:new Rt.bD,[Rt.AL.T_SNE]:new Rt.aP},this.tableInput=s.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=s.columnInput(Ot[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=s.choiceInput("Method",Rt.AL.UMAP,[Rt.AL.UMAP,Rt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);let e=!1;this.similarityMetricInput=s.choiceInput("Similarity",lt.gk.Tanimoto,P.Rt)}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],r=s.floatInput(i.uiName,i.value,(()=>{i.value=r.value}));s.tooltip.bind(r.root,i.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=s.columnInput(Ot[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),s.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Gt extends Pt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=s.boolInput("Plot Embeddings",!0),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Ft extends Pt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.intInput("Similarity cutoff",80),s.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),s.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Wt,Vt=function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};class Ht{constructor(t,e,n=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Ht.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,n;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const s=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,s,""),(null===(e=null===(t=s.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(n=s.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Vt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=n,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),yield this._countdown(n,i,a),yield(0,kt.gw)(a);const l=s.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Vt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Vt(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Ht.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Vt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Zt(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;i.shell.error(e),ue.logger.error(t.message,void 0,n)}Ht.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Wt||(Wt={}));const Ut="data/sample_FASTA_PT_activity.csv";var Dt=n(1811),Bt=function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};function Yt(){return Bt(this,void 0,void 0,(function*(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(yield e[0].prepare().call()).getOutputParamValue()}))}var zt=function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};function Xt(){return zt(this,void 0,void 0,(function*(){return yield i.functions.call("Dendrogram:getDendrogramService",{})}))}const qt="data/sample_FASTA_PT_activity.csv",Kt="sequence";var jt=n(3336),$t=n.n(jt);const Jt="data/sample_FASTA_PT_activity.csv";var Qt=n(8341);const te="samples/sample_HELM.csv";var ee=n(2568),ne=n(525);class ie{constructor(){this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${ue.name}.${this._funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:"sequence"});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class se{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=s.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var re=n(9900),oe=n(2098);const ae=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},le={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class he{constructor(t){this.grid=t,this.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,n){if(t.grid.dart!=this.grid.dart||!t.tableColumn||!t.isTableCell||"Monomer"!=t.tableColumn.semType)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new oe.j(me().getBioLib()).getCappedRotatedMonomer(a,o),h=s.div(o),c=l?i.chem.svgMol(l,void 0,void 0,le):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return s.tooltip.show(s.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){const e=t.dataFrame.temp;return ae.tooltipHandlerTemp in e||(e[ae.tooltipHandlerTemp]=new he(t),t.temp=e),e[ae.tooltipHandlerTemp]}}class ce extends r.GridCellRenderer{get name(){return u.Of.MONOMER}get cellType(){return u.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 30}render(t,e,n,i,s,r,o){if(r.gridRow<0)return;he.getOrCreate(r.grid),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,h.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const c=a.get(l);t.fillStyle=c,t.fillText((0,h.GU)(l,3),e+i/2,n+s/2,i)}}const ue=new r.Package;function me(){return _t.NT.instance}let de=null;class fe{constructor(t){this._palette=t}get(t){return 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Search");t.dockManager.dock(e,"down")}function Xe(){const t=(0,St.m)();(0,I.gQ)(t)}function qe(){(0,It.C2)()}function Ke(){return new Lt.ST}async function je(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new ie,e=await ue.files.readCsv("data/sample_PT_10000.csv");await i.data.detectSemanticTypes(e),await t.init(e,"webLogoLargeApp")}finally{t.close()}}async function $e(){await async function(){let t,e;try{const n=new Ht("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await n.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await ue.files.readCsv(Ut),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const n=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(n,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(n,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function Je(){await async function(){let t,e,n,s,o;try{const a=new Ht("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[s,t,e]=await Promise.all([ue.files.readCsv(qt),Yt(),Xt()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,n,i){let s;{const t=Object.values(Wt);for(let n=0;n<t.length;n++){const i=t[n];if(!e.col(i)){const s=n==t.length-1;e.columns.add(r.Column.float(i,e.rowCount),s)}}if(e.rowCount>=1){const i=e.getCol(n).toList(),s=Date.now();ue.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await A(i,"UMAP",lt.W.Levenshtein,{}),o=Date.now();ue.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-s)/1e3} s`);for(let n=0;n<t.length;n++){const i=t[n],s=e.getCol(i),o=r.embedding[n];s.init((t=>o[t]))}const a=Date.now();ue.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}s=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Wt.X,yColumnName:Wt.Y,lassoTool:!0})}return t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),s}(n,s,Kt)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=s.getCol(Kt).toList(),r=j.H.calc(i,((t,e)=>Dt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(n.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{s.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=s.getCol("sequence_id");s.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),s.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){Zt(t)}}()}async function Qe(){await async function(){let t,e,n,s,o;const a=Rt.AL.UMAP;try{const l=new Ht("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[n,t,e]=await Promise.all([ue.files.readCsv(Jt),Yt(),Xt()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=300,s.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await Ae(n,n.getCol("Sequence"),n.getCol("Activity"),80,a),s.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),$t()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol("sequence").toList(),r=j.H.calc(i,((t,e)=>Dt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0),s.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function tn(){await async function(){const t="HELM";let e,n,o;try{await new Ht("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await ue.files.readCsv("samples/sample_HELM.csv"),n=i.shell.addTableView(e);for(let e=0;e<n.grid.columns.length;e++){const i=n.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=e.getCol(t);await ke(e,n)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${t})`;e.currentCell=e.cell(1,n);const i=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),o=s.dialog().add(a).show(),await(0,kt.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function en(){await async function(){let t,e,n,s,o,a;const l="msa(HELM)",h=Rt.AL.UMAP;try{const c=new Ht("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await ue.files.readCsv(te)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{n=e.getCol("HELM");const t=Qt.J[0];s=await(0,Qt.f)(n,l,t,1.53,0,void 0),e.columns.add(s),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await Le(e,s,h,_.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Zt(t)}}()}},9017:(t,e,n)=>{"use strict";n.d(e,{k:()=>r});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class s{constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=r+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:r+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const s=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[s][e].parentJ}return new s(n,i,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let s=1;s<=this.len2;s++)this.fillOne(i,s),this.dpGrid[i][s].value<=0?(this.dpGrid[i][s].value=0,this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0):0==this.dpGrid[this.dpGrid[i][s].parentI][this.dpGrid[i][s].parentJ].value&&(this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0),this.dpGrid[i][s].value>t&&(t=this.dpGrid[i][s].value,e=i,n=s);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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y{constructor(t,e,n={},i=0,s=0){this.pos=t,this.name=e,this.freq=n,this.rowCount=i,this.sumForHeightCalc=s}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(f||(f={}));const b=u.vS;class w extends r.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){return"auto"===this.positionMarginState&&!0===this.unitsHandler?.getAlphabetIsMultichar()||"enable"===this.positionMarginState?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=w.viewerCount,w.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(f.sequenceColumnName,b.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(f.startPositionName,b.startPositionName,{category:d.DATA}),this.endPositionName=this.string(f.endPositionName,b.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(f.skipEmptySequences,b.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(f.skipEmptyPositions,b.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(f.shrinkEmptyTail,b.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(f.backgroundColor,b.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(f.positionHeight,b.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(f.positionWidth,b.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(f.verticalAlignment,b.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(f.horizontalAlignment,b.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(f.fixWidth,b.fixWidth,{category:d.LAYOUT}),this.fitArea=this.bool(f.fitArea,b.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(f.minHeight,b.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(f.maxHeight,b.maxHeight,{category:d.LAYOUT}),this.positionMarginState=this.string(f.positionMarginState,b.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(f.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(f.filterSource,b.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=s.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=s.canvas(),this.canvas.style.width="100%"}init(){this.initialized?p._package.logger.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=s.div("No message"),this.msgHost.style.display="none",this.canvas=s.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=s.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(l.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(l.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(l.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}destroyView(){const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}buildView(){super.onTableAttached();const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.C.getOrCreate(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol)}catch(t){this.seqCol=null,this.msgHost.innerText=`${t}`,this.msgHost.style.setProperty("display",null)}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...this.unitsHandler.splitted.map((t=>t.length))):0,n=this.seqCol.getTag(u.DX.positionNames);this.positionNames=n?n.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),n=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,n=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,n)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case f.sequenceColumnName:case f.startPositionName:case f.endPositionName:case f.filterSource:this.updateSeqCol();break;case f.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case f.fixWidth:case f.fitArea:case f.positionMargin:this.updateSlider();break;case f.shrinkEmptyTail:case f.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){p._package.logger.debug("Bio: WebLogoViewer.onTableAttached(), "),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,n=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),i=this.positions[n];if(null==i)return[n,null,null];const s=Object.keys(i.freq).find((n=>i.freq[n].bounds.contains(e,t.y)));return void 0===s?[n,null,null]:[n,s,i.freq[s]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const n=t.length;let i=0;for(let s=0;s<n;s++)e(t[s])||(t[i]=t[s],i++);return t.length=i,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>t?.freq["-"]?.count===t.rowCount))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=h.C.getOrCreate(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new y(this.startPosition+t,e)}const n=this.filter.getSelectedIndexes();this.rowsMasked=n.length;for(const t of n){const e=this.unitsHandler.splitted[t];for(let t=0;t<this.Length;t++){const n=this.positions[t].freq,i=e[this.startPosition+t]||"-";i in n||(n[i]=new g),n[i].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==u.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const n=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-n*Math.log2(n)}}}this._removeEmptyPositions();const s=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const n=this.positions[e].freq,o=this.positions[e].rowCount,a=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==a&&i.shell.error("WebLogo: alphabet is undefined.");const l=Math.log2(a),h=this.positionHeight==u.ES.Entropy?s*(l-this.positions[e].sumForHeightCalc)/l:s;let c=this.axisHeight*t+(s-h-1);const m=Object.entries(n).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of m){const n=t[1],i=h*n.count/o;n.bounds=new r.Rect(e*this.positionWidthWithMargin,c,this._positionWidth,i),c+=i}}}render(t=!0){if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const n=window.devicePixelRatio;t&&this._calculate(n),e.resetTransform(),e.fillStyle=r.Color.toHtml(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const i=this.countOfRenderPositions+1,s=this.visibleSlider?Math.floor(this.slider.min):0,o=Math.min(this.Length,s+i),a=10*n;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth-2?1:(this._positionWidth-2)/l;for(let t=this.firstVisibleIndex;t<o;t++){const n=this.positions[t];e.resetTransform(),e.setTransform(h,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*s,0),e.fillText(n.name,0,0)}for(let t=this.firstVisibleIndex;t<o;t++)for(const[n,i]of Object.entries(this.positions[t].freq))if("-"!==n){const t=(0,c.GU)(n,5),s=i.bounds,r=s.left-this.positionWidthWithMargin*this.firstVisibleIndex;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(r,s.top,s.width,s.height),e.fillStyle=this.cp.get(n)??this.cp.get("other"),e.textAlign="left",e.font="16px Roboto, Roboto Local, sans-serif";const o=e.measureText(t);e.setTransform(s.width/o.width,0,0,s.height/12.2,r,s.top),e.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,n=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,n*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${n}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let s=0;switch(this.verticalAlignment){case"top":s=0;break;case"middle":s=Math.max(0,(this.root.clientHeight-n)/2);break;case"bottom":s=Math.max(0,this.root.clientHeight-n-t)}let r=0;switch(this.horizontalAlignment){case"left":r=0;break;case"center":r=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":r=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${s}px`,"important"),this.host.style.setProperty("margin-left",`${r}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${s+i}px`,"important"),this.root.clientHeight<=n?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,n=window.devicePixelRatio,i=this.canvas.getCursorPosition(e,n),[r,o]=this.getMonomer(i);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],n=function(t,e,n,i,s){return a().count(0).take(t.rowCount).filter((t=>n.get(t))).map((t=>{const n=e.splitted[t],i=s.pos;return i<n.length?n[i]:null})).toArray().filter((t=>t==i)).reduce(((t,e)=>t+1),0)}(this.dataFrame,this.unitsHandler,this.filter,o,t),i=s.div([s.div(`${o}`),s.div(`${n} rows`)]);s.tooltip.show(i,e.x+16,e.y+16)}else s.tooltip.hide()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,s]=this.getMonomer(this.canvas.getCursorPosition(e,n));if(this.dataFrame&&this.seqCol&&this.unitsHandler&&s){const t=this.positions[i],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,n,i,s,r){if(!n.getSelectedIndexes().includes(i))return!1;const o=e.splitted[i],a=r.pos<o.length?o[r.pos]:null;return a===s||""===a&&"-"===s}(this.dataFrame,this.unitsHandler,this.filter,e,s,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const e=t.deltaY/100*Math.max(Math.floor(this.countOfRenderPositions/2),1);this.slider.scrollBy(this.slider.min+e)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnWheel() error:\n"+e)}}}w.residuesSet="nucleotides",w.viewerCount=-1},4413:(t,e,n)=>{"use strict";n.d(e,{ST:()=>d});var i=n(3870),s=n(976),r=n(4469),o=n(6414),a=n.n(o),l=n(7983),h=n(701),c=n(4293),u=n(1061);const m=rxjs.operators;class d extends s.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(s.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(s.TAGS.UNITS)),this.bioFilter="fasta"===this.notation?new p:"separator"===this.notation?new g(this.column.getTag("separator")):new y,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,m.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class f{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class p extends f{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class g extends p{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class y extends f{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:n}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const 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+ var bio;(()=>{var t={6e3:(t,e,s)=>{"use strict";var n;s(4469),s(976),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(n||(n={}))},8867:(t,e,s)=>{"use strict";s.d(e,{OW:()=>n});class n extends Float32Array{}},7997:(t,e,s)=>{"use strict";function n(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function i(t){let e=0;for(let s=0;s<t.length;s++)e+=t[s]*t[s];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let s=0;for(let n=0;n<t.length;n++)s+=t[n]*e[n];return s}s.d(e,{$G:()=>i,MA:()=>r,hu:()=>n}),s(8867)},2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>i});var n=s(9976);class i extends n.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in i.aaSynonyms?i.aaSynonyms[t]:t;return super.get(e)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",n="";for(const i of t)"("==i?e++:")"==i?e--:e?s+=i:n+=i;return isNaN(parseInt(s))?[n,s]:[n,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[n,i]=this.getInnerOuter(t);if(n=n.length>6?`${n.slice(0,3)}...`:n,i=i.length>6?`${i.slice(0,3)}...`:i,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,i,1]:[this.undefinedColor,n,i,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,i,2]:[this.undefinedColor,n,i,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,i,3]:[this.undefinedColor,n,i,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,i,4]:[this.undefinedColor,n,i,4]}return[this.undefinedColor,n,i,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>o,Xk:()=>r});var n=s(976),i=(s(4469),s(1047));function r(t){const e=[];for(let s=0;s<t.rowCount;s++){const n={};Object.keys(i.K4).forEach((e=>{if("symbol"===e){const r=t.get(i.K4[e],s);n[e]="."===r?t.get(i.At,s):r}else if("rgroups"===e){const r=t.get(i.K4[e],s).split("\n"),o=[];r.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),n=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${n}][H]`:`O[*:${n}]`,e.alternateId="H"===s?`R${n}-H`:`R${n}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${n}`,o.push(e)})),n[e]=o}else i.K4[e]&&(n[e]=t.get(i.K4[e],s))})),e.push(n)}return e}async function o(){const t=n.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installer for MonomerLibraryHelper.');return(await t[0].prepare().call()).getOutputParamValue()}s(585)},2098:(t,e,s)=>{"use strict";s.d(e,{j:()=>n});class n{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}},6375:(t,e,s)=>{"use strict";s.d(e,{i0:()=>m});var n=s(4469),i=s(976),r=s(7767),o=s(499);const a={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var l=s(1047);function h(t){return Math.round(a.PRECISION_FACTOR*t)/a.PRECISION_FACTOR}function c(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?c(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}s(6e3);var u=s(8447);async function m(t,e,h){if(0===i.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==i.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${i.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let m=e;o.C.getOrCreate(e).isHelm()&&(m=new r.L(e).convert("separator","."),m.name=e.name);const f=o.C.getOrCreate(m).alphabet;let p;if("PT"===f||"UN"===f)p="PEPTIDE";else{if("RNA"!==f&&"DNA"!==f)return{col:null,warnings:[`Unexpected column's '${m.name}' alphabet '${f}'.`]};p="RNA"}const g=function(t){const e=t.length,s=new Array(e),n=t.getTag(i.TAGS.UNITS),r=t.getTag("separator"),o=(0,u.vU)(n,r);for(let n=0;n<e;++n){const 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o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:n,polymerType:i,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(g,y,f,p,w);if(v.length>.05*w)throw new Error("Too many errors getting molfiles.");const C=`molfile(${m.name})`,S=t.columns.getUnusedName(C),M=i.Column.fromStrings(S,b);return M.semType=i.SEMTYPE.MOLECULE,M.setTag(i.TAGS.UNITS,i.UNITS.Molecule.MOLBLOCK),{col:M,warnings:v}}function d(t,e,s,n,i,r){if(!t.has(e)){const o=function(t,e,s,n,i){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),l=function(t){const e=new Map;let s=t.indexOf(a.V2K_A_LINE,0),n=s;for(;-1!==s;){n=t.indexOf("\n",s);const i=parseInt(t.substring(s,n).replace(/^A\s+/,""));s=t.indexOf("R",n),n=t.indexOf("\n",s);const r=parseInt(t.substring(s,n).replace(/^R/,""));e.set(i,r),s=t.indexOf(a.V2K_A_LINE,n)}for(s=t.indexOf(a.V2K_RGP_LINE,0),n=t.indexOf("\n",s);-1!==s;){s+=a.V2K_RGP_SHIFT,n=t.indexOf("\n",s);const i=t.substring(s,n).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<i.length;t+=2){if(e.has(i[t])&&e.get(i[t])!==i[t+1])throw new Error(`r-group index ${i[t]} has already been added with a different value`);e.set(i[t],i[t+1])}s=t.indexOf(a.V2K_RGP_LINE,n)}return e}(r.molfile),c=function(t,e){const s=e.get_mol(t),n=s.get_v3Kmolblock();return s.delete(),n}(function(t){let e=t.indexOf(a.V2K_A_LINE,0);-1===e&&(e=t.indexOf(a.V2K_RGP_LINE));const s=t.indexOf(a.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),u=function(t){let e=(t=t.replaceAll("\r","")).indexOf(a.V3K_BEGIN_COUNTS_LINE)+a.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const n=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(t.substring(e,s))}}(c),m=function(t,e){const s=new Array(e),n=new Float32Array(e),i=new Float32Array(e),r=new Array(e);let o=t.indexOf(a.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let l=o;for(let h=0;h<e;h++){o=t.indexOf(a.V3K_BEGIN_DATA_LINE,o)+a.V3K_IDX_SHIFT,l=t.indexOf(" ",o),o=l+1,l=t.indexOf(" ",o),s[h]=t.substring(o,l);const e=new Array(2);for(let s=0;s<2;++s)o=l+1,l=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,l));n[h]=e[0],i[h]=e[1],o=l,l=t.indexOf("\n",o)+1,r[h]=t.slice(o,l),o=l}return{atomTypes:s,x:n,y:i,kwargs:r}}(c,u.atomCount),d=function(t,e){const s=new Uint32Array(e),n=new 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s=this.column.get(e),n=this.splitter(s),i=[];for(let e=0;e<n.length;e++){const s=n[e];if(0===s.length)i.push(t);else if(s.length>1){const t="["+s+"]";i.push(t)}else i.push(s)}return i.join("")})),e.setTag(n.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,s,n){n||(n=this.toFasta(e)?i.C._defaultGapSymbolsDict.FASTA:i.C._defaultGapSymbolsDict.SEPARATOR),s||(s=this.toFasta(e)?"":this.separator);const r=/(R\(|D\(|\)|P)/g,o=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let s=a[t];if(o&&(s=s.replace(r,"")),s===i.C._defaultGapSymbolsDict.HELM)l.push(n);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";l.push(t)}else l.push(s)}return l.join(s)}convertHelm(t,e,s){const n=this.getNewColumn(t,e);n.init((n=>{const i=this.column.get(n);return this.convertHelmToFastaSeparator(i,t,e,s)})),(0,r.Mj)(n);const i=this.stats.sameLength?"SEQ.MSA":"SEQ";return n.setTag("aligned",i),n}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,s)=>{"use strict";s.d(e,{C:()=>h});var n=s(976),i=s(1821),r=s(585),o=s(489),a=s(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${n.SEMTYPE.MACROMOLECULE}`}};class h{static setUnitsToFastaColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||"fasta"!==t.column.getTag(n.TAGS.UNITS))throw new Error(`The column of notation 'fasta' must be '${n.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(n.TAGS.UNITS,"fasta"),h.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||"separator"!==t.column.getTag(n.TAGS.UNITS))throw new Error(`The column of notation 'separator' must be '${n.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error("The column of notation 'separator' must have the separator tag.");t.column.setTag(n.TAGS.UNITS,"separator"),t.column.setTag("separator",e),h.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation 'helm' must be '${n.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(n.TAGS.UNITS,"helm"),h.setTags(t)}static setTags(t){const e=t.column.getTag(n.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),["fasta","separator"].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");const e=s.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const n=(0,r.w4)(s.freq,i.XS);if(t.column.setTag("alphabet",n),"UN"===n){const e=Object.keys(s.freq).length,n=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",n?"true":"false")}}}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if("separator"===this.notation&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return"helm"===this.notation||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),n=this._column.categories;for(let i=0;i<e;i++){const e=n[s[i]];this._splitted[i]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const n of this.splitted){null==s?s=n.length:n.length!==s&&(e=!1);for(const e of n)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t,e){const s=this.column,i=s.length,r=t.toLowerCase()+"("+s.name+")",o=s.dataFrame.columns.getUnusedName(r),a=n.Column.fromList("string",o,new Array(i).fill(""));if(a.semType=n.SEMTYPE.MACROMOLECULE,a.setTag(n.TAGS.UNITS,t),"separator"===t){if(!e)throw new Error("Notation 'separator' requires separator value.");a.setTag("separator",e)}a.setTag(n.TAGS.CELL_RENDERER,"Macromolecule");const l=s.getTag("aligned");l&&a.setTag("aligned",l);const h=s.getTag("alphabet");h&&a.setTag("alphabet",h);let c=s.getTag(".alphabetSize");c&&a.setTag(".alphabetSize",c);const u=s.getTag(".alphabetIsMultichar");return void 0!==u&&a.setTag(".alphabetIsMultichar",u),"helm"==t&&(c=this.getAlphabetSize().toString(),a.setTag(".alphabetSize",c)),a}static getNewColumn(t){const e=h.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!h.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const i=n.Column.fromList("string",e,new Array(t).fill(""));return i.semType=n.SEMTYPE.MACROMOLECULE,i.setTag(n.TAGS.UNITS,s),i}getSplitter(){return(0,r.Mj)(this._column)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,r.Ar)(this.separator);for(const t of this.column.categories){const n=s(t);for(const t of n)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}constructor(t){this._splitted=null,this._stats=null,this._column=t;const e=this._column.getTag(n.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h._defaultGapSymbolsDict.FASTA:this.isHelm()?h._defaultGapSymbolsDict.HELM:h._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())h.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");h.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(n.TAGS.UNITS)}'.`);h.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new h(t)),t.temp[l.uhTemp]}}h._defaultGapSymbolsDict={HELM:"*",SEPARATOR:"",FASTA:"-"}},9298:(t,e,s)=>{"use strict";var n,i,r,o,a;s.d(e,{CI:()=>h,Ct:()=>a,DX:()=>c,ES:()=>n,dE:()=>o,iD:()=>r,vS:()=>l,vw:()=>i}),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(i||(i={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(r||(r={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(o||(o={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(a||(a={}));const l=new 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s=t.toString();if(s.length<=e)return s;let n=t.toFixed(e);if(n.length>e&&(n=t.toFixed(Math.max(0,e-(n.length-e)))),n.length<=e&&!n.startsWith("0.000")&&!n.startsWith("-0.000"))return n;let i=t.toExponential(e);return i.length>e&&(i=t.toExponential(Math.max(0,e-(i.length-e)))),i.slice(0)}function w(t,e,s){let n=s?t.rows:t.rows-1;if(e<0||e>n)throw new RangeError("Row index out of range")}function b(t,e,s){let n=s?t.columns:t.columns-1;if(e<0||e>n)throw new RangeError("Column index out of range")}function v(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.columns)throw new RangeError("vector size must be the same as the number of columns");return e}function C(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.rows)throw new RangeError("vector size must be the same as the number of rows");return e}function S(t,e,s,n,i){if(5!==arguments.length)throw new RangeError("expected 4 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A(s,n);for(let r=0;r<s;r++)for(let s=0;s<n;s++)i.set(r,s,Math.min(t.get(r,s),e.get(r,s)));return i}static max(t,e){t=this.checkMatrix(t),e=this.checkMatrix(e);let s=t.rows,n=t.columns,i=new this(s,n);for(let r=0;r<s;r++)for(let s=0;s<n;s++)i.set(r,s,Math.max(t.get(r,s),e.get(r,s)));return i}static checkMatrix(t){return x.isMatrix(t)?t:new A(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.call(this,e,s);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.push(this.get(e,s));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let s=0;s<this.columns;s++)t[e].push(this.get(e,s))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 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i=t.get(n,s)/t.get(e,s);t.set(n,s,0);for(let r=s+1;r<t.columns;r++)t.set(n,r,t.get(n,r)-t.get(e,r)*i)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,n=s-1;for(;n>=0;)if(0===t.maxRow(n))n--;else{let i=0,r=!1;for(;i<s&&!1===r;)1===t.get(n,i)?r=!0:i++;for(let s=0;s<n;s++){let r=t.get(s,i);for(let o=i;o<e;o++){let e=t.get(s,o)-r*t.get(n,o);t.set(s,o,e)}}n--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let n=new A(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)n.setSubMatrix(this,this.rows*t,this.columns*e);return n}fill(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,t);return this}neg(){return this.mulS(-1)}getRow(t){w(this,t);let e=[];for(let s=0;s<this.columns;s++)e.push(this.get(t,s));return e}getRowVector(t){return A.rowVector(this.getRow(t))}setRow(t,e){w(this,t),e=v(this,e);for(let s=0;s<this.columns;s++)this.set(t,s,e[s]);return this}swapRows(t,e){w(this,t),w(this,e);for(let s=0;s<this.columns;s++){let n=this.get(t,s);this.set(t,s,this.get(e,s)),this.set(e,s,n)}return this}getColumn(t){b(this,t);let e=[];for(let s=0;s<this.rows;s++)e.push(this.get(s,t));return e}getColumnVector(t){return A.columnVector(this.getColumn(t))}setColumn(t,e){b(this,t),e=C(this,e);for(let s=0;s<this.rows;s++)this.set(s,t,e[s]);return this}swapColumns(t,e){b(this,t),b(this,e);for(let s=0;s<this.rows;s++){let n=this.get(s,t);this.set(s,t,this.get(s,e)),this.set(s,e,n)}return this}addRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[s]);return this}subRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=v(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=C(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){w(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){b(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){E(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let n=0;n<this.columns;n++)this.get(s,n)>t&&(t=this.get(s,n),e[0]=s,e[1]=n);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){E(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let n=0;n<this.columns;n++)this.get(s,n)<t&&(t=this.get(s,n),e[0]=s,e[1]=n);return e}maxRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){w(this,t),E(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n),s[1]=n);return s}minRow(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){w(this,t),E(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n),s[1]=n);return s}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){b(this,t),E(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t),s[0]=n);return s}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){b(this,t),E(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t),s[0]=n);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){x.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let n=0;n<e.length;n++)s+=e[n]*t[n];return s}mmul(t){t=A.checkMatrix(t);let e=this.rows,s=this.columns,n=t.columns,i=new A(e,n),r=new Float64Array(s);for(let o=0;o<n;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let n=0;n<s;n++)e+=this.get(t,n)*r[n];i.set(t,o,e)}}return i}strassen2x2(t){t=A.checkMatrix(t);let e=new A(2,2);const s=this.get(0,0),n=t.get(0,0),i=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(n+h),u=(o+l)*n,m=s*(r-h),d=l*(a-n),f=(s+i)*h,p=c+d-f+(i-l)*(a+h),g=m+f,y=u+d,w=c-u+m+(o-s)*(n+r);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,y),e.set(1,1,w),e}strassen3x3(t){t=A.checkMatrix(t);let e=new A(3,3);const s=this.get(0,0),n=this.get(0,1),i=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),f=t.get(1,0),p=t.get(1,1),g=t.get(1,2),y=t.get(2,0),w=t.get(2,1),b=t.get(2,2),v=(s-r)*(-m+p),C=(-s+r+o)*(u-m+p),S=(r+o)*(-u+m),M=s*u,T=(-s+l+h)*(u-d+g),E=(-s+l)*(d-g),x=(l+h)*(-u+d),N=(-i+h+c)*(p+y-w),I=(i-c)*(p-w),L=i*y,_=(h+c)*(-y+w),k=(-i+o+a)*(g+y-b),R=(i-a)*(g-b),O=(o+a)*(-y+b),G=M+L+n*f,P=(s+n+i-r-o-h-c)*p+C+S+M+N+L+_,F=M+T+x+(s+n+i-o-a-l-h)*g+L+k+O,V=v+o*(-u+m+f-p-g-y+b)+C+M+L+k+R,W=v+C+S+M+a*w,H=L+k+R+O+r*d,D=M+T+E+h*(-u+d+f-p-g-y+w)+N+I+L,Z=N+I+L+_+l*m,U=M+T+E+x+c*b;return e.set(0,0,G),e.set(0,1,P),e.set(0,2,F),e.set(1,0,V),e.set(1,1,W),e.set(1,2,H),e.set(2,0,D),e.set(2,1,Z),e.set(2,2,U),e}mmulStrassen(t){t=A.checkMatrix(t);let e=this.clone(),s=e.rows,n=e.columns,i=t.rows,r=t.columns;function o(t,e,s){let n=t.rows,i=t.columns;if(n===e&&i===s)return t;{let n=x.zeros(e,s);return n=n.setSubMatrix(t,0,0),n}}n!==i&&console.warn(`Multiplying ${s} x ${n} and ${i} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,i),l=Math.max(n,r);return e=o(e,a,l),function t(e,s,n,i){if(n<=512||i<=512)return e.mmul(s);n%2==1&&i%2==1?(e=o(e,n+1,i+1),s=o(s,n+1,i+1)):n%2==1?(e=o(e,n+1,i),s=o(s,n+1,i)):i%2==1&&(e=o(e,n,i+1),s=o(s,n,i+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),f=e.subMatrix(r,e.rows-1,a,e.columns-1),p=s.subMatrix(r,s.rows-1,a,s.columns-1),g=t(x.add(l,f),x.add(h,p),r,a),y=t(x.add(m,f),h,r,a),w=t(l,x.sub(u,p),r,a),b=t(f,x.sub(d,h),r,a),v=t(x.add(l,c),p,r,a),C=t(x.sub(m,l),x.add(h,u),r,a),S=t(x.sub(c,f),x.add(d,p),r,a),M=x.add(g,b);M.sub(v),M.add(S);let T=x.add(w,v),E=x.add(y,b),N=x.sub(g,y);N.add(w),N.add(C);let A=x.zeros(2*M.rows,2*M.columns);return A=A.setSubMatrix(M,0,0),A=A.setSubMatrix(T,M.rows,0),A=A.setSubMatrix(E,0,M.columns),A=A.setSubMatrix(N,M.rows,M.columns),A.subMatrix(0,n-1,0,i-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new A(this.rows,this.columns);for(let t=0;t<this.rows;t++){const i=this.getRow(t);i.length>0&&m(i,{min:e,max:s,output:i}),n.setRow(t,i)}return n}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new A(this.rows,this.columns);for(let t=0;t<this.columns;t++){const i=this.getColumn(t);i.length&&m(i,{min:e,max:s,output:i}),n.setColumn(t,i)}return n}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),n=this.get(e,this.columns-1-s);this.set(e,s,n),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),n=this.get(this.rows-1-s,e);this.set(s,e,n),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=A.checkMatrix(t);let e=this.rows,s=this.columns,n=t.rows,i=t.columns,r=new A(e*n,s*i);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<n;s++)for(let a=0;a<i;a++)r.set(n*o+s,i*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=A.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,n=this.kroneckerProduct(A.eye(s,s)),i=A.eye(e,e).kroneckerProduct(t);return n.add(i)}transpose(){let t=new A(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=N){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=N){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,n){S(this,t,e,s,n);let i=new A(e-t+1,n-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=n;e++)i.set(r-t,e-s,this.get(r,e));return i}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let n=new A(t.length,s-e+1);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.rows)throw new RangeError(`Row index out of range: ${t[i]}`);n.set(i,r-e,this.get(t[i],r))}return n}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let n=new A(s-e+1,t.length);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.columns)throw new RangeError(`Column index out of range: ${t[i]}`);n.set(r-e,i,this.get(r,t[i]))}return n}setSubMatrix(t,e,s){if((t=A.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)this.set(e+n,s+i,t.get(n,i));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new A(t.length,e.length);for(let n=0;n<t.length;n++){let i=t[n];for(let t=0;t<e.length;t++){let r=e[t];s.set(n,t,this.get(i,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new A(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]+=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]+=t.get(s,n);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e+=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]*=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]*=t.get(s,n);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e*=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:n=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(o,e)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,n);case"column":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(e,o)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,n);case void 0:if("number"!=typeof n)throw new TypeError("mean must be a number");return function(t,e,s){const n=t.rows,i=t.columns,r=n*i;let o=0,a=0,l=0;for(let e=0;e<n;e++)for(let n=0;n<i;n++)l=t.get(e,n)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,n);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[n])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let n=0;for(let e=0;e<t.columns;e++)n+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let n=0;for(let e=0;e<t.rows;e++)n+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[n])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let n=0;n<t.columns;n++)for(let i=0;i<t.rows;i++)s+=Math.pow(t.get(i,n),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function N(t,e){return t-e}x.prototype.klass="Matrix","undefined"!=typeof Symbol&&(x.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),x.random=x.rand,x.randomInt=x.randInt,x.diagonal=x.diag,x.prototype.diagonal=x.prototype.diag,x.identity=x.eye,x.prototype.negate=x.prototype.neg,x.prototype.tensorProduct=x.prototype.kroneckerProduct;class A extends x{constructor(t,e){if(super(),A.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let n=0;n<t;n++){if(s[n].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[n].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[n]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return w(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),w(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let n=0;n<t;n++)s[n]=this.data[e][n];for(let n=t+1;n<this.columns;n++)s[n-1]=this.data[e][n];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let s=0;s<this.rows;s++){const n=new Float64Array(this.columns+1);let i=0;for(;i<t;i++)n[i]=this.data[s][i];for(n[i++]=e[s];i<this.columns+1;i++)n[i]=this.data[s][i-1];this.data[s]=n}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(x,A);class I extends x{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,s,n,i,r,o,a,l,h,c=(t=I.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),f=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,n=0;n<h;n++)r+=c.get(e,n)*l[n];l[e]-=r,c.set(e,s,l[e])}for(i=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[i])&&(i=e);if(i!==s){for(n=0;n<m;n++)o=c.get(i,n),c.set(i,n,c.get(s,n)),c.set(s,n,o);a=d[i],d[i]=d[s],d[s]=a,f=-f}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=f}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=A.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,i,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(i=0;i<a;i++)for(s=i+1;s<a;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i));for(i=a-1;i>=0;i--){for(n=0;n<r;n++)o.set(i,n,o.get(i,n)/e.get(i,i));for(s=0;s<i;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let n=0;n<s;n++)e*=t.get(n,n);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new A(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new A(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class k{constructor(t){let e,s,n,i,r=(t=I.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(n=0;n<a;n++){let t=0;for(e=n;e<o;e++)t=_(t,r.get(e,n));if(0!==t){for(r.get(n,n)<0&&(t=-t),e=n;e<o;e++)r.set(e,n,r.get(e,n)/t);for(r.set(n,n,r.get(n,n)+1),s=n+1;s<a;s++){for(i=0,e=n;e<o;e++)i+=r.get(e,n)*r.get(e,s);for(i=-i/r.get(n,n),e=n;e<o;e++)r.set(e,s,r.get(e,s)+i*r.get(e,n))}}l[n]=-t}this.QR=r,this.Rdiag=l}solve(t){t=A.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,i,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(i=0;i<a;i++){for(o=0,n=r;n<s;n++)o+=e.get(n,r)*l.get(n,i);for(o=-o/e.get(r,r),n=r;n<s;n++)l.set(n,i,l.get(n,i)+o*e.get(n,r))}for(r=h-1;r>=0;r--){for(i=0;i<a;i++)l.set(r,i,l.get(r,i)/this.Rdiag[r]);for(n=0;n<r;n++)for(i=0;i<a;i++)l.set(n,i,l.get(n,i)-l.get(r,i)*e.get(n,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,i=new A(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?i.set(t,e,s.get(t,e)):t===e?i.set(t,e,this.Rdiag[t]):i.set(t,e,0);return i}get orthogonalMatrix(){let t,e,s,n,i=this.QR,r=i.rows,o=i.columns,a=new A(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==i.get(s,s)){for(n=0,t=s;t<r;t++)n+=i.get(t,s)*a.get(t,e);for(n=-n/i.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+n*i.get(t,s))}}return a}}class R{constructor(t,e={}){if((t=I.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,n=t.columns;const{computeLeftSingularVectors:i=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(i),h=Boolean(r),c=!1;if(s<n)if(o){a=t.transpose(),s=a.rows,n=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,n),m=Math.min(s+1,n),d=new Float64Array(m),f=new A(s,u),p=new A(n,n),g=new Float64Array(n),y=new Float64Array(s),w=new Float64Array(m);for(let t=0;t<m;t++)w[t]=t;let b=Math.min(s-1,n),v=Math.max(0,Math.min(n-2,s)),C=Math.max(b,v);for(let t=0;t<C;t++){if(t<b){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<n;e++){if(t<b&&0!==d[t]){let n=0;for(let i=t;i<s;i++)n+=a.get(i,t)*a.get(i,e);n=-n/a.get(t,t);for(let i=t;i<s;i++)a.set(i,e,a.get(i,e)+n*a.get(i,t))}g[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<s;e++)f.set(e,t,a.get(e,t));if(t<v){g[t]=0;for(let e=t+1;e<n;e++)g[t]=_(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<n;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<s&&0!==g[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<n;s++)y[e]+=g[s]*a.get(e,s);for(let e=t+1;e<n;e++){let n=-g[e]/g[t+1];for(let i=t+1;i<s;i++)a.set(i,e,a.get(i,e)+n*y[i])}}if(h)for(let e=t+1;e<n;e++)p.set(e,t,g[e])}}let S=Math.min(n,s+1);if(b<n&&(d[b]=a.get(b,b)),s<S&&(d[S-1]=0),v+1<S&&(g[v]=a.get(v,S-1)),g[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<s;e++)f.set(e,t,0);f.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let n=0;for(let i=t;i<s;i++)n+=f.get(i,t)*f.get(i,e);n=-n/f.get(t,t);for(let i=t;i<s;i++)f.set(i,e,f.get(i,e)+n*f.get(i,t))}for(let e=t;e<s;e++)f.set(e,t,-f.get(e,t));f.set(t,t,1+f.get(t,t));for(let e=0;e<t-1;e++)f.set(e,t,0)}else{for(let e=0;e<s;e++)f.set(e,t,0);f.set(t,t,1)}}if(h)for(let t=n-1;t>=0;t--){if(t<v&&0!==g[t])for(let e=t+1;e<n;e++){let s=0;for(let i=t+1;i<n;i++)s+=p.get(i,t)*p.get(i,e);s=-s/p.get(t+1,t);for(let i=t+1;i<n;i++)p.set(i,e,p.get(i,e)+s*p.get(i,t))}for(let e=0;e<n;e++)p.set(e,t,0);p.set(t,t,1)}let M=S-1,T=0,E=Number.EPSILON;for(;S>0;){let 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n=s(4469),i=s(3870),r=s(976);const o=s(585).GU;var a;!function(t){t.MSA="MSA",t.classic="classic"}(a||(a={}));const l=(t,e,s,n,i,r,l="rgb(100,100,100)",h=0,c=!1,u=1,m="",d=!1,f=a.classic,p={},g=0,y=null,w=[],b=null)=>{i.textAlign="start";let v=r.substring(0),C=d?"":m;f===a.MSA&&(C="");let S=!0,M=!0,T="difference";null!=y&&null!=y.cell.column&&(S=y.cell.column.temp["color-code"]??!0,M=y.cell.column.temp["compare-with-current"]??!0,T=y.cell.column.temp["highlight-difference"]??"difference");const E=w[g];M&&w.length>0&&"difference"===T&&(u=v==E?.3:u),M&&w.length>0&&"equal"===T&&(u=v!=E?.3:u),null!=b&&(v=o(v,b));let x=i.measureText(v+C),N=i.measureText(v).width,A=i.measureText(v).width;const I=n/2-(x.fontBoundingBoxAscent+x.fontBoundingBoxDescent)/2+1;function L(s,n){const r=S?l:"rgb(0,0,0)";i.fillStyle=r,i.globalAlpha=u,f===a.classic&&(i.fillText(v,t+s,e+I),i.fillStyle="#808080",i.fillText(C,t+n,e+I)),f===a.MSA&&(i.fillStyle=r,i.fillText(v,t+s+(p[g]-A)/2,e+I))}if(x=x.width,f===a.MSA&&(N=p[g],x=p[g]),c||x>s)return L(5,5+N),t+N+i.measureText(C).width;{const e=(s-x)/2;return L(e,e+N),t+e+N}};var h=s(8447),c=s(7331),u=s(3553);const m="rgb(100,100,100)",d=h.GU;function f(t,e,s,n){return t?Math.min(t.canvas.width-s,n):e.canvas.width-s}function p(t){const e=!t.some(((e,s)=>e.length>1&&0!=s&&s!=t.length-1)),s=[],n=e?"":" ";return t.forEach(((e,i)=>{i<t.length&&(e+=`${e?"":"-"}${n}`),s.push(e)})),[s,e]}class g extends r.GridCellRenderer{get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){if("SEQ.MSA"!==t.cell.column.getTag("aligned"))return;const s=t.cell.column.temp,n=s["bio-sum-maxLengthWords"],r=s["bio-maxIndex"],o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-t.bounds.x);let a=0,l=r,c=!1;n[r+1]=o+1;let u=0;if(o>n[0])for(;!c;)u=Math.floor((l+a)/2),o>=n[u]&&o<=n[u+1]?(a=u,c=!0):o<n[u]?l=u-1:o>n[u+1]&&(a=u+1),a==l&&(c=!0);a=o>=n[a]?a+1:a;const m=t.cell.column.getTag("separator")??"",d=(0,h.vU)("separator",m)(t.cell.value);(d[a]?.length??0)>0?i.tooltip.show(i.div(d[a]),e.x+16,e.y+16):i.tooltip.hide()}render(t,e,s,n,i,o,c){const u=-1!==o.gridRow?o.grid:null,p=o.cell,g=o.cell.column.getTag("alphabet");n=f(u,t,e,n),t.save(),t.beginPath(),t.rect(e,s,n,i),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=o.cell.column.getTag(r.TAGS.UNITS),w=o.cell.column.getTag("aligned"),b=(0,h.py)(g),v=o.cell.column.getTag("separator")??"",C=n/5,S=(0,h.vU)(y,v,C),M=o.cell.column.temp,T=M["reference-sequence"],E=M["current-word"],x=M["monomer-width"],N=S(null!=T&&""!=T?T:E??"");let A=5,I=0,L=8;"short"===(x??"short")&&(A=12,L=M[".mm.cellRenderer.maxMonomerLength"]??de.properties.maxMonomerLength);let _={};if(o.cell.column.getTag(".mm.cellRenderer.calculated")!==C.toString()){let t=0;for(;t<Math.min(o.cell.column.length,100);)S(o.cell.column.get(t)).forEach(((t,e)=>{const s=7*d(t,L).length+A;s>(_[e]??0)&&(_[e]=s),e>I&&(I=e)})),t+=1;const e=21;for(let t=0;t<=I;t++){_[t]<e&&(_[t]=e);const s={};s[0]=_[0];for(let t=1;t<=I;t++)s[t]=s[t-1]+_[t];M["bio-sum-maxLengthWords"]=s,M["bio-maxIndex"]=I,M["bio-maxLengthWords"]=_,o.cell.column.setTag(".mm.cellRenderer.calculated",C.toString())}}else _=M["bio-maxLengthWords"];const k=S(p.value);let R=e,O=m,G=a.classic;w&&w.includes("MSA")&&"separator"==y&&(G=a.MSA),k.every(((e,r)=>{O=b.get(e),t.fillStyle=m;const a=r===k.length-1;return R=l(R,s,n,i,t,e,O,0,!0,1,v,a,G,_,r,o,N,L),50<=n})),t.restore()}}class y extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return u.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,n,i,o,a){const l=o.grid,c=o.cell.value??"",u=o.tableColumn.tags.separator,m=o.tableColumn.tags[r.TAGS.UNITS];n=f(l,t,e,n);const[d,p]=c.split("#"),g=(0,h.vU)(m,u);w(t,e,s,n,i,g(d),g(p),m)}}function w(t,e,s,n,i,r,o,a,u,m){if(r.length!==o.length){const t=function(t,e){let s=0,n=0;const i=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)i[t]===r[t]&&s++;const o=i.length-r.length;for(let t=i.length-1;t>o;t--)i[t]===r[t-o]&&n++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>n?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(r,o);r=t.subParts1,o=t.subParts2}const d=t.measureText(p(r).join("")),f=t.measureText(p(o).join("")),g=Math.max(d.width,f.width);u&&(n=g+4*r.length,t.canvas.width=g+4*r.length);let y=Math.max(e,e+(n-(g+4*r.length))/2);const w=Math.max(s,s+(i-28)/2);t.save(),t.beginPath(),t.rect(e,s,u?g+4*r.length:n,i),t.clip(),t.font="12px monospace",t.textBaseline="top";let v=c.UE.Color;"HELM"!=a&&(v=(0,h.py)(a.substring(a.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],h=v.get(s);if(s!=a){const r=v.get(a),o=l(y,w-7,n,i,t,s,h,0,!0),c=l(y,w+7,n,i,t,a,r,0,!0);y=Math.max(c,o),m&&(m[e]=b(s,a,h,r,w,7,i))}else y=l(y,w,n,i,t,s,h,0,!0,.5);y+=4}t.restore()}function b(t,e,s,n,i,r,o){const a=document.createElement("canvas"),h=a.getContext("2d");h.font="12px monospace";const c=h.measureText(p([t]).join("")).width,u=h.measureText(p([e]).join("")).width,m=Math.max(c,u);return a.height=o,a.width=m+4,h.font="12px monospace",h.textBaseline="top",l(0,i-r,m,o,h,t,s,0,!0),l(0,i+r,m,o,h,e,n,0,!0),a}var v,C=s(701),S=s(2121),M=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(v||(v={})),new class{constructor(){this.regionTypes=[v.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=M.ES.Entropy}};const T=v;class E extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.regionTypes=this.stringList("regionTypes",[T.CDR],{choices:Object.values(T).filter((t=>t!=T.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16),this.positionHeight=this.string("positionHeight",M.ES.Entropy,{choices:Object.keys(M.ES)})}async init(){this.subs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.subs.push(C.fromEvent(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}async onTableAttached(){const t=super.onTableAttached.bind(this);this.viewPromise=this.viewPromise.then((async()=>{t(),this.viewed||(await this.buildView("onTableAttached"),this.viewed=!0)}))}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){console.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})),this.regions=e,this.dataFrame=t,this.viewPromise=this.viewPromise.then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)}))}detach(){const t=super.detach.bind(this);this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}async destroyView(t){console.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&i.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){console.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort();this.logos=[];for(let t=0;t<s.length;t++){const n={};for(const i of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==i));n[i]=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight})}this.logos[t]=n}this.mainLayout=i.table(this.chains,(t=>[...s.length>0?[i.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",i.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=i.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",i.tooltip.bind(this.filterSourceInput.root,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=i.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),console.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){const t=(this.root.clientHeight-54)/this.chains.length,e=Math.min(t,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));for(let t=0;t<this.logos.length;t++)for(let s=0;s<this.chains.length;s++){const n=this.chains[s];this.logos[t][n].root.style.height=`${e}px`}}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?M.Ct.Selected:M.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const n=this.chains[s];this.logos[e][n].setOptions({[S.bo.filterSource]:t})}}}var x=s(9017),N=s(850);async function A(t,e,n,i,r){const o=await async function(t,e,n,i){return new Promise((function(r,o){const a=new Worker(new URL(s.p+s.u(729),s.b));a.postMessage({columnData:t.data,method:e,measure:t.metric,options:n,parallelDistanceWorkers:i}),a.onmessage=({data:{error:t,distance:e,embedding:s}})=>{t?o(t):r({distance:e,embedding:s}),setTimeout((()=>a.terminate()),0)}}))}({data:t,metric:n},e,i,r);return o.embedding=o.embedding.map((t=>(0,N.Fv)(t))),o}var I=s(7983),L=s(499),_=s(7767),k=s(489);async function R(t){const e=new _.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=k.U.LEVENSHTEIN,n=t.seqCol.toList();if(e.isSeparator()){const t=e.convert("fasta");n=t.toList(),s=L.C.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<n.length;e++)n[e]=t.seqCol.isNone(e)?null:n[e];const i=await A(n,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,i.embedding[e])));return{distance:i.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,I.HV)(t.seqCol,!1),await n.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function O(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var G=s(5697),P=s(3379),F=s.n(P),V=s(7795),W=s.n(V),H=s(569),D=s.n(H),Z=s(3565),U=s.n(Z),B=s(9216),Y=s.n(B),z=s(4589),X=s.n(z),K=s(9414),q={};q.styleTagTransform=X(),q.setAttributes=U(),q.insert=D().bind(null,"head"),q.domAPI=W(),q.insertStyleElement=Y(),F()(K.Z,q),K.Z&&K.Z.locals&&K.Z.locals;var j=s(3914),$=s(6254);let J=0;const Q="cliffsDf",tt=new C.Subject,et="act_diff",st="sali",nt="sim",it="line_index",rt=["1_seq","2_seq"],ot="filterCliffs";function at(t,e,s){const n=e.getBoundingClientRect(),i=t.clientX-n.left,r=t.clientY-n.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-i,t.a[1]-r)+Math.hypot(t.b[0]-i,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var lt=s(1040);async function ht(t,e,s,i,o){e.version!==e.temp["last-invalidated-version"]&&await(0,I.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(i).init((t=>e.temp["monomeric-mols"].get(t))),await n.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:i,simArr:o})}function ct(t){const e=i.divH([]),s=i.divV([i.divText(t.seqCol.name),i.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,n)=>{const r=i.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(i.divV([i.divText(t.seqCol.get(s)),r]))})),e}function ut(t){const e=i.div();e.append(i.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);t.line.mols.forEach(((e,i)=>{s[i]=t.seqCol.get(e),n[i]=t.activityCol.get(e)}));const o={},a=t.seqCol.getTag(r.TAGS.UNITS),l=t.seqCol.getTag("separator"),c=(0,h.vU)(a,l),u=dt(c(s[0]),c(s[1]),a,o);return e.append(i.div(u,{style:{width:"300px",overflow:"scroll"}})),e.append(ft(o)),e.append(mt("Activity delta",Math.abs(n[0]-n[1]))),e.append(mt("Cliff",t.sali)),e}function mt(t,e){return i.divH([i.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),i.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function dt(t,e,s,n){const i=document.createElement("canvas"),r=i.getContext("2d");return i.height=30,w(r,0,0,0,30,t,e,s,!0,n),i}function ft(t){const e=i.div();if(Object.keys(t).length>0){const s=i.divV([]);s.append(i.divH([i.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),i.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(i.divH([i.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function pt(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const n=t.plot.grid();return n.col(e[0]).visible=!1,n.col(e[1]).visible=!1,n}s(7861);var gt,yt=s(4004),wt=s(7228);!function(t){t.long="long",t.short="short"}(gt||(gt={}));var bt=s(6375),vt=s(5226);s(9133);class Ct extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",G.kg[0],{choices:G.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(i.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(n.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var St=s(7241),Mt=s(4293),Tt=s(2669);async function Et(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=L.C.getOrCreate(t).getDistanceFunctionName(),n=new Tt.m(!0,!1),i=await n.calc(e,s);return n.terminate(),i}function xt(t){return(e,s)=>{const n=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?n(e,s):n(s,e)}}class Nt extends Ct{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new C.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=L.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const i=s.plot.grid();i.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));i.cell("score",o).cell.value=null,n.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Mt.Y)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,St.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await n.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Et(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const n=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const i=L.C.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),n.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(n.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*n.length/o),u=s===a.length-1?Math.floor((s+1)*n.length/o):n.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:n,max:i}})=>{t?o(t):(h=Math.min(h,n),c=Math.max(c,i),l.set(e,r),s())},t.postMessage({fnName:i,values:n,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,n=xt(e),i=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[n(this.targetMoleculeIdx,s)]:1-t[s]})));i.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=i.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=i.div(),s={},o=this.molCol?.name,a=t.col(o).getTag(r.TAGS.UNITS),l=t.col(o).getTag("separator"),c=(0,h.vU)(a,l),u=c(this.moleculeColumn.get(this.targetMoleculeIdx)),m=c(t.get(o,t.currentRowIdx)),d=dt(u,m,a,s);e.append(i.div(d,{style:{width:"300px",overflow:"scroll"}})),u.length!==m.length&&e.append(i.divV([i.divText("Different sequence length:",{style:{fontWeight:"bold"}}),i.divText(`target: ${u.length} monomers`),i.divText(`selected: ${m.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(ft(s));const f=i.accordion(),p=i.element("i");p.className="grok-icon svg-icon svg-view-layout",f.addTitle(i.span([p,i.label("Similarity search")])),f.addPane("Differences",(()=>e),!0),n.shell.o=f.root}}var At=s(8518);class It extends Ct{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new C.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=L.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([s]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]})),(0,Mt.Y)(this.root,n.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,St.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await n.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Et(this.moleculeColumn),e=this.moleculeColumn.length,s=xt(e);this.renderMolIds=(0,At.L)(e,Math.min(e,this.limit),((e,n)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(n)?0:t[s(e,n)]))}}var Lt=s(9943),_t=s(4413),kt=s(1061),Rt=s(1345),Ot=s(116);const Gt={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Pt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=i.inputs([]),this.methodsParams={[Ot.AL.UMAP]:new Ot.bD,[Ot.AL.T_SNE]:new Ot.aP},this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=i.columnInput(Gt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=i.choiceInput("Method",Ot.AL.UMAP,[Ot.AL.UMAP,Ot.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=i.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):i.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=i.inputs([]);let e=!1;this.similarityMetricInput=i.choiceInput("Similarity",lt.gk.Tanimoto,G.Rt)}createAlgorithmSettingsDiv(t,e){return i.empty(t),Object.keys(e).forEach((s=>{const n=e[s],r=i.floatInput(n.uiName,n.value,(()=>{n.value=r.value}));i.tooltip.bind(r.root,n.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=i.columnInput(Gt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),i.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Ft extends Pt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=i.boolInput("Plot Embeddings",!0),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Vt extends Pt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=i.intInput("Similarity cutoff",80),i.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),i.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Wt,Ht=function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?i(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((n=n.apply(t,e||[])).next())}))};class Dt{constructor(t,e,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._stopStartBtn=i.button(i.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=i.button(i.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=i.button(i.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._closeBtn=i.button(i.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Dt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=i.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(i.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=i.iconFA("clock");this._isAutomatic||0===e&&(s=i.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=i.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=i.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=i.divH([s,n],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;n.shell.windows.showContextPanel=!0,n.shell.windows.showHelp=!1;const i=Array.from(n.shell.dockManager.rootNode.children)[0];this._node=n.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,i,""),(null===(e=null===(t=i.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=i.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Ht(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),yield this._countdown(s,n,a),yield(0,kt.gw)(a);const l=i.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=i.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Ht(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return Ht(this,void 0,void 0,(function*(){const n=i.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);n.append(o),t.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){n.shell.dockManager.close(this._node),n.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){n.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Dt.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return Ht(this,void 0,void 0,(function*(){this._initRoot(),n.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Zt(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),de.logger.error(t.message,void 0,s)}Dt.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Wt||(Wt={}));const Ut="data/sample_FASTA_PT_activity.csv";var Bt=s(1811);async function Yt(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function zt(){return await n.functions.call("Dendrogram:getDendrogramService",{})}const Xt="data/sample_FASTA_PT_activity.csv",Kt="sequence";var qt=s(3336),jt=s.n(qt);const $t="data/sample_FASTA_PT_activity.csv";var Jt=s(8341);const Qt="samples/sample_HELM.csv";var te=s(2568),ee=s(525);class se{constructor(){this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){this.view=n.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${de.name}.${this._funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:"sequence"});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ne{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=i.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=i.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=i.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var ie=s(9900),re=s(2098);const oe=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},ae={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class le{constructor(t){this.grid=t,this.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.grid.dart||!t.tableColumn||!t.isTableCell||"Monomer"!=t.tableColumn.semType)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new re.j(fe().getBioLib()).getCappedRotatedMonomer(a,o),h=i.div(o),c=l?n.chem.svgMol(l,void 0,void 0,ae):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return i.tooltip.show(i.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){const e=t.dataFrame.temp;return oe.tooltipHandlerTemp in e||(e[oe.tooltipHandlerTemp]=new le(t),t.temp=e),e[oe.tooltipHandlerTemp]}}class he extends r.GridCellRenderer{get name(){return u.Of.MONOMER}get cellType(){return u.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 30}render(t,e,s,n,i,r,o){if(r.gridRow<0)return;le.getOrCreate(r.grid),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,h.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const c=a.get(l);t.fillStyle=c,t.fillText((0,h.GU)(l,3),e+n/2,s+i/2,n)}}class ce extends Map{get onPropertyChanged(){return this._onPropertyChanged}get maxMonomerLength(){return super.get("MaxMonomerLength")}set maxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new C.Subject}}class ue extends r.Package{get properties(){return this._properties}set properties(t){this._properties=t}}class me extends r.Widget{constructor(t){super(i.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength}async init(){const t=i.intInput("Max monomer length",de.properties.maxMonomerLength,(t=>{de.properties.maxMonomerLength=t}));this.root.appendChild(i.form([t]))}}const de=new ue;function fe(){return Rt.NT.instance}let pe=null;class ge{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function ye(){let t;await Promise.all([(async()=>{await Rt.NT.instance.loadLibraries()})(),(async()=>{t=await n.functions.call("Chem:getRdKitModule")})(),(async()=>{const t=await de.getProperties(),e=new ce(t);de.properties=e})()]);const e=Rt.NT.instance.getBioLib(),s=[],i=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const n=r[e].replaceAll("#R","O "),o=t.get_mol(n),a=JSON.parse(o.get_descriptors()).CrippenClogP;i.push(a),o?.delete()}));const o=i.reduce(((t,e)=>t+e),0)/i.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=i[t]<o?"#4682B4":"#DC143C";pe=new ge(a)}async function we(t){const e=n.shell.tv,s=await e.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:t.name,backgroundColor:4294836197,fitArea:!1,positionHeight:"Entropy",fixWidth:!0});return s.root.style.height="50px",s}function be(){return Rt.NT.instance.getBioLib()}async function ve(){const t=i.dialog({title:"Manage files"}).add(i.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function Ce(t){const e=i.button("Manage",ve),s=i.inputs([]),o=await(0,Rt.P4)();let a=Promise.resolve();for(const t of o){const e=await(0,Rt.nW)(),r=i.boolInput(t,!e.exclude.includes(t),(()=>{a=a.then((async()=>{1==r.value?e.exclude=e.exclude.filter((e=>e!=t)):e.exclude.includes(t)||e.exclude.push(t),await(0,Rt.QD)(e),await Rt.NT.instance.loadLibraries(!0),n.shell.info("Monomer library user settings saved.")}))}));s.append(r.root)}return new r.Widget(i.divV([s,i.div(e)]))}function Se(t){const e=new me(t);return e.init().then(),e}function Me(){return new g}function Te(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=i.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:"short",["short","long"],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.calculated","0"),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const n=i.intInput("Max monomer 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n.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/s.length,`Test ${a.fileName}`)}n.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}function Ue(t){const e=new ne;i.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}async function Be(t,e){await(0,ie.n)(t,e)}function Ye(t){const e=L.C.getOrCreate(t).stats;return Object.keys(e.freq)}function ze(){return new Nt}function Xe(){const t=n.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Ke(){return new It}function qe(){const t=n.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function je(){const t=(0,Mt.m)();(0,I.gQ)(t)}function $e(){(0,Lt.C2)()}function Je(){return new _t.ST}async function Qe(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new se,e=await de.files.readCsv("data/sample_PT_10000.csv");await n.data.detectSemanticTypes(e),await t.init(e,"webLogoLargeApp")}finally{t.close()}}async function ts(){await async function(){let t,e;try{const s=new Dt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await de.files.readCsv(Ut),t=n.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function es(){await async function(){let t,e,s,i,o;try{const a=new Dt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[i,t,e]=await Promise.all([de.files.readCsv(Xt),Yt(),zt()]),s=n.shell.addTableView(i),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,n){let i;{const t=Object.values(Wt);for(let s=0;s<t.length;s++){const n=t[s];if(!e.col(n)){const i=s==t.length-1;e.columns.add(r.Column.float(n,e.rowCount),i)}}if(e.rowCount>=1){const n=e.getCol(s).toList(),i=Date.now();de.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await A(n,"UMAP",lt.W.Levenshtein,{}),o=Date.now();de.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-i)/1e3} s`);for(let s=0;s<t.length;s++){const n=t[s],i=e.getCol(n),o=r.embedding[s];i.init((t=>o[t]))}const a=Date.now();de.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}i=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Wt.X,yColumnName:Wt.Y,lassoTool:!0})}return t.dockManager.dock(i,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(s,i,Kt)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const n=i.getCol(Kt).toList(),r=j.H.calc(n,((t,e)=>Bt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=i.getCol("sequence_id");i.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){Zt(t)}}()}async function ss(){await async function(){let t,e,s,i,o;const a=Ot.AL.UMAP;try{const l=new Dt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([de.files.readCsv($t),Yt(),zt()]),i=n.shell.addTableView(s),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await _e(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),i.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),jt()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const n=s.getCol("sequence").toList(),r=j.H.calc(n,((t,e)=>Bt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(i.grid,o,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function ns(){await async function(){const t="HELM";let e,s,o;try{await new Dt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await de.files.readCsv("samples/sample_HELM.csv"),s=n.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const n=s.grid.columns.byIndex(e);[t,"Activity"].includes(n.name)||(n.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await Oe(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const n=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(n),o=i.dialog().add(a).show(),await(0,kt.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){Zt(t)}}()}async function is(){await async function(){let t,e,s,i,o,a;const l="msa(HELM)",h=Ot.AL.UMAP;try{const c=new Dt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=n.shell.addTableView(e=await de.files.readCsv(Qt)),n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=Jt.J[0];i=await(0,Jt.f)(s,l,t,1.53,0,void 0),e.columns.add(i),await n.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await Re(e,i,h,k.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Zt(t)}}()}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class n{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class i{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",n="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,n=this.seq2.substr((e-1)*this.step,this.step)+n):this.dpGrid[t][e].parentJ==e?(n=r+n,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,n=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+n:r+n);const i=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[i][e].parentJ}return new i(s,n,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let n=1;n<=this.len1;n++)for(let i=1;i<=this.len2;i++)this.fillOne(n,i),this.dpGrid[n][i].value<=0?(this.dpGrid[n][i].value=0,this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0):0==this.dpGrid[this.dpGrid[n][i].parentI][this.dpGrid[n][i].parentJ].value&&(this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0),this.dpGrid[n][i].value>t&&(t=this.dpGrid[n][i].value,e=n,s=i);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,n=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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y{constructor(t,e,s={},n=0,i=0){this.pos=t,this.name=e,this.freq=s,this.rowCount=n,this.sumForHeightCalc=i}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(f||(f={}));const w=u.vS;class b extends r.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){return"auto"===this.positionMarginState&&!0===this.unitsHandler?.getAlphabetIsMultichar()||"enable"===this.positionMarginState?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=b.viewerCount,b.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(f.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(f.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(f.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(f.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(f.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(f.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(f.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(f.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(f.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(f.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(f.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(f.fixWidth,w.fixWidth,{category:d.LAYOUT}),this.fitArea=this.bool(f.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(f.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(f.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.positionMarginState=this.string(f.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(f.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(f.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=i.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=i.canvas(),this.canvas.style.width="100%"}init(){this.initialized?p._package.logger.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=i.div("No message"),this.msgHost.style.display="none",this.canvas=i.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=i.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(l.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(l.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(l.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}destroyView(){const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}buildView(){super.onTableAttached();const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.C.getOrCreate(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol)}catch(t){this.seqCol=null,this.msgHost.innerText=`${t}`,this.msgHost.style.setProperty("display",null)}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...this.unitsHandler.splitted.map((t=>t.length))):0,s=this.seqCol.getTag(u.DX.positionNames);this.positionNames=s?s.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),s=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,s=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,s)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case f.sequenceColumnName:case f.startPositionName:case f.endPositionName:case f.filterSource:this.updateSeqCol();break;case f.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case f.fixWidth:case f.fitArea:case f.positionMargin:this.updateSlider();break;case f.shrinkEmptyTail:case f.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){p._package.logger.debug("Bio: WebLogoViewer.onTableAttached(), "),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,s=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),n=this.positions[s];if(null==n)return[s,null,null];const i=Object.keys(n.freq).find((s=>n.freq[s].bounds.contains(e,t.y)));return void 0===i?[s,null,null]:[s,i,n.freq[i]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const s=t.length;let n=0;for(let i=0;i<s;i++)e(t[i])||(t[n]=t[i],n++);return t.length=n,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>t?.freq["-"]?.count===t.rowCount))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=h.C.getOrCreate(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new y(this.startPosition+t,e)}const s=this.filter.getSelectedIndexes();this.rowsMasked=s.length;for(const t of s){const e=this.unitsHandler.splitted[t];for(let t=0;t<this.Length;t++){const s=this.positions[t].freq,n=e[this.startPosition+t]||"-";n in s||(s[n]=new g),s[n].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==u.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const s=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-s*Math.log2(s)}}}this._removeEmptyPositions();const i=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const s=this.positions[e].freq,o=this.positions[e].rowCount,a=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==a&&n.shell.error("WebLogo: alphabet is undefined.");const l=Math.log2(a),h=this.positionHeight==u.ES.Entropy?i*(l-this.positions[e].sumForHeightCalc)/l:i;let c=this.axisHeight*t+(i-h-1);const m=Object.entries(s).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of m){const s=t[1],n=h*s.count/o;s.bounds=new r.Rect(e*this.positionWidthWithMargin,c,this._positionWidth,n),c+=n}}}render(t=!0){if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const s=window.devicePixelRatio;t&&this._calculate(s),e.resetTransform(),e.fillStyle=r.Color.toHtml(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const n=this.countOfRenderPositions+1,i=this.visibleSlider?Math.floor(this.slider.min):0,o=Math.min(this.Length,i+n),a=10*s;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth-2?1:(this._positionWidth-2)/l;for(let t=this.firstVisibleIndex;t<o;t++){const s=this.positions[t];e.resetTransform(),e.setTransform(h,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*i,0),e.fillText(s.name,0,0)}for(let t=this.firstVisibleIndex;t<o;t++)for(const[s,n]of Object.entries(this.positions[t].freq))if("-"!==s){const t=(0,c.GU)(s,5),i=n.bounds,r=i.left-this.positionWidthWithMargin*this.firstVisibleIndex;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(r,i.top,i.width,i.height),e.fillStyle=this.cp.get(s)??this.cp.get("other"),e.textAlign="left",e.font="16px Roboto, Roboto Local, sans-serif";const o=e.measureText(t);e.setTransform(i.width/o.width,0,0,i.height/12.2,r,i.top),e.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,s=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,s*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${s}px`);const n=this.host.clientHeight;if(this.canvas.height=n*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${s}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let i=0;switch(this.verticalAlignment){case"top":i=0;break;case"middle":i=Math.max(0,(this.root.clientHeight-s)/2);break;case"bottom":i=Math.max(0,this.root.clientHeight-s-t)}let r=0;switch(this.horizontalAlignment){case"left":r=0;break;case"center":r=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":r=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${i}px`,"important"),this.host.style.setProperty("margin-left",`${r}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${i+n}px`,"important"),this.root.clientHeight<=s?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,s=window.devicePixelRatio,n=this.canvas.getCursorPosition(e,s),[r,o]=this.getMonomer(n);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],s=function(t,e,s,n,i){return a().count(0).take(t.rowCount).filter((t=>s.get(t))).map((t=>{const s=e.splitted[t],n=i.pos;return n<s.length?s[n]:null})).toArray().filter((t=>t==n)).reduce(((t,e)=>t+1),0)}(this.dataFrame,this.unitsHandler,this.filter,o,t),n=i.div([i.div(`${o}`),i.div(`${s} rows`)]);i.tooltip.show(n,e.x+16,e.y+16)}else i.tooltip.hide()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[n,i]=this.getMonomer(this.canvas.getCursorPosition(e,s));if(this.dataFrame&&this.seqCol&&this.unitsHandler&&i){const t=this.positions[n],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,n,i,r){if(!s.getSelectedIndexes().includes(n))return!1;const o=e.splitted[n],a=r.pos<o.length?o[r.pos]:null;return a===i||""===a&&"-"===i}(this.dataFrame,this.unitsHandler,this.filter,e,i,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const e=t.deltaY/100*Math.max(Math.floor(this.countOfRenderPositions/2),1);this.slider.scrollBy(this.slider.min+e)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnWheel() error:\n"+e)}}}b.residuesSet="nucleotides",b.viewerCount=-1},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>d});var n=s(3870),i=s(976),r=s(4469),o=s(6414),a=s.n(o),l=s(7983),h=s(701),c=s(4293),u=s(1061);const m=rxjs.operators;class d extends i.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=n.loader(),this.notation=void 0,this.root=n.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(i.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(i.TAGS.UNITS)),this.bioFilter="fasta"===this.notation?new p:"separator"===this.notation?new g(this.column.getTag("separator")):new y,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,m.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class f{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class p extends f{constructor(){super(),this.substructureInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class g extends p{constructor(t){super(),this.colSeparator="",this.separatorInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return n.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class y extends f{constructor(){super(),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await n.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);n.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),n.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const 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