@datagrok/bio 2.4.31 → 2.4.39

package/dist/package.js

@@ -1,2 +1,2 @@
-var bio;(()=>{var t={8867:(t,e,n)=>{"use strict";n.d(e,{OW:()=>i});class i extends Float32Array{}},7997:(t,e,n)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function o(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}n.d(e,{$G:()=>s,MA:()=>o,hu:()=>i}),n(8867)},2012:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(9976);class s extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,s)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,s)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new s({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in s.aaSynonyms?s.aaSynonyms[t]:t;return super.get(e)}}s.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(t="grok"){switch(t){case"grok":return s.GrokGroups;case"lesk":return s.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const s of t)"("==s?e++:")"==s?e--:e?n+=s:i+=s;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){var n,i,s;const o=this.getPalette(e);let[r,a]=this.getInnerOuter(t);if(r=r.length>6?`${r.slice(0,3)}...`:r,a=a.length>6?`${a.slice(0,3)}...`:a,1==t.length||"("==t[1]){const e=null===(n=t[0])||void 0===n?void 0:n.toUpperCase();return e in o?[o.get(e),e,a,1]:[this.undefinedColor,r,a,1]}if("d"==t[0]&&t[1]in o&&(2==t.length||"("==t[2])){const e=null===(i=t[1])||void 0===i?void 0:i.toUpperCase();return e in o?[o.get(e),e,a,2]:[this.undefinedColor,r,a,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in o?[o.get(e),e,a,3]:[this.undefinedColor,r,a,3]}if((null===(s=t[0])||void 0===s?void 0:s.toLowerCase())==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in o?[o.get(e),e,a,4]:[this.undefinedColor,r,a,4]}return[this.undefinedColor,r,a,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,n)=>{"use strict";n.d(e,{DC:()=>r,JN:()=>l,Xk:()=>a});var i=n(976),s=(n(4469),n(1047)),o=(n(585),function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))});const r=["symbol","name","molfile","rgroups","polymerType","monomerType"];function a(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(s.K4).forEach((e=>{if("symbol"===e){const o=t.get(s.K4[e],n);i[e]="."===o?t.get(s.At,n):o}else if("rgroups"===e){const o=t.get(s.K4[e],n).split("\n"),r=[];o.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,r.push(e)})),i[e]=r}else s.K4[e]&&(i[e]=t.get(s.K4[e],n))})),e.push(i)}return e}function l(){return o(this,void 0,void 0,(function*(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installer for MonomerLibraryHelper.');return(yield t[0].prepare().call()).getOutputParamValue()}))}},1731:(t,e,n)=>{"use strict";n.d(e,{i0:()=>P});var i=n(4469),s=n(976),o=n(1047),r=n(585),a=n(7767);function l(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?l(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var h=n(499),c=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};const u=8,d="M  RGP",f="A  ",m=14,p=7,g="\nDatagrok macromolecule handler\n\n",v="  0  0  0  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o?r.substring(0,e)+"…":r}function x(t,e,n="-"){const i=e.map((e=>{const i=function(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const s=[],o=[];for(const n of i)s.push(n in t?t[n]:0),o.push(e.has(n)?1:0);const r=new h.OW(s),a=new h.OW(o);return(0,c.MA)(r,a)/((0,c.$G)(r)*(0,c.$G)(a))}(t,e.alphabet,n);return new r.d(e,t,i)}));let s;const o=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return s=o>0?i.find((t=>t.similarity===o)).name:"UN",s}function T(t,e=5){let n;return n=t.semType==i.SEMTYPE.MACROMOLECULE?new l.C(t).alphabet:x(m(t,e,p).freq,a.XS),N(n)}function N(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return d.J.Chromatogram;default:return f.UE.Color}}function E(t){var e;const n=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=null!==(e=n.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")})))&&void 0!==e?e:null;return!s&&n.length>0&&(s=n[0]),s}},7767:(t,e,n)=>{"use strict";n.d(e,{L:()=>r});var i=n(976),s=n(499),o=n(585);class r extends s.C{get splitter(){return null===this._splitter&&(this._splitter=(0,o.Mj)(this.column)),this._splitter}toFasta(t){return"fasta"===t}toSeparator(t){return"separator"===t}toHelm(t){return"helm"===t}convertFastaToSeparator(t,e=null){null===e&&(e=this.defaultGapSymbol);const n=this.getNewColumn("separator",t);return n.init((n=>{const i=this.column.get(n),o=this.splitter(i);for(let t=0;t<o.length;t++)o[t]===e&&(o[t]=s.C._defaultGapSymbolsDict.SEPARATOR);return o.join(t)})),n.setTag(i.TAGS.UNITS,"separator"),n}getHelmWrappers(){const t=this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":this.isPeptide()?"PEPTIDE1{":"Unknown";if("Unknown"===t)throw new Error("Neither peptide, nor nucleotide");return[t,this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}convertToHelmHelper(t,e,n,i,o,r){return`${n}${this.splitter(t).map((t=>t===e?s.C._defaultGapSymbolsDict.HELM:`${i}${t}${o}`)).join(".")}${r}`}convertStringToHelm(t,e=null){null===e&&(e=this.defaultGapSymbol);const[n,i,s,o]=this.getHelmWrappers();return this.convertToHelmHelper(t,e,n,i,s,o)}convertToHelm(t=null){null===t&&(t=this.defaultGapSymbol);const[e,n,s,o]=this.getHelmWrappers(),r=this.getNewColumn("helm");return r.init((i=>{const r=this.column.get(i);return this.convertToHelmHelper(r,t,e,n,s,o)})),r.setTag(i.TAGS.UNITS,"helm"),r}convertSeparatorToFasta(t=null){null===t&&(t=s.C._defaultGapSymbolsDict.FASTA);const e=this.getNewColumn("fasta");return e.init((e=>{const n=this.column.get(e),i=this.splitter(n),s=[];for(let e=0;e<i.length;e++){const n=i[e];if(0===n.length)s.push(t);else if(n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join("")})),e.setTag(i.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?s.C._defaultGapSymbolsDict.FASTA:s.C._defaultGapSymbolsDict.SEPARATOR),n||(n=this.toFasta(e)?"":this.separator);const o=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let n=a[t];if(r&&(n=n.replace(o,"")),n===s.C._defaultGapSymbolsDict.HELM)l.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";l.push(t)}else l.push(n)}return l.join(n)}convertHelm(t,e,n){const i=this.getNewColumn(t,e);i.init((i=>{const s=this.column.get(i);return this.convertHelmToFastaSeparator(s,t,e,n)}));const s=(0,o.Mj)(i),r=(0,o.fy)(i,5,s).sameLength?"SEQ.MSA":"SEQ";return i.setTag("aligned",r),i}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,n)=>{"use strict";n.d(e,{C:()=>l});var i=n(976),s=n(1821),o=n(585),r=n(489),a=n(7228);class l{static setUnitsToFastaColumn(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE||"fasta"!==t.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'fasta' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.setTag(i.TAGS.UNITS,"fasta"),l.setTags(t,o.kB)}static setUnitsToSeparatorColumn(t,e){if(t.semType!==i.SEMTYPE.MACROMOLECULE||"separator"!==t.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'separator' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error("The column of notation 'separator' must have the separator tag.");t.setTag(i.TAGS.UNITS,"separator"),t.setTag("separator",e),l.setTags(t,(0,o.Ar)(e))}static setUnitsToHelmColumn(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation 'helm' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.setTag(i.TAGS.UNITS,"helm"),l.setTags(t,o.gP)}static setTags(t,e){const n=t.getTag(i.TAGS.UNITS),r=(0,o.fy)(t,5,e);if(Object.keys(r.freq).some((t=>t.length>1)),["fasta","separator"].includes(n)){if(0===Object.keys(r.freq).length)throw new Error("Alphabet is empty");const e=r.sameLength?"SEQ.MSA":"SEQ";t.setTag("aligned",e);const n=(0,o.w4)(r.freq,s.XS);if(t.setTag("alphabet",n),"UN"===n){const e=Object.keys(r.freq).length,n=Object.keys(r.freq).some((t=>t.length>1));t.setTag(".alphabetSize",e.toString()),t.setTag(".alphabetIsMultichar",n?"true":"false")}}}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){var t;const e=null!==(t=this.column.getTag("separator"))&&void 0!==t?t:void 0;if("separator"===this.notation&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=(0,o.Mj)(this.column),n=(0,o.fy)(this.column,1,t);e=Object.keys(n.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return"helm"===this.notation||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t,e){const n=this.column,s=n.length,o=t.toLowerCase()+"("+n.name+")",r=n.dataFrame.columns.getUnusedName(o),a=i.Column.fromList("string",r,new Array(s).fill(""));if(a.semType=i.SEMTYPE.MACROMOLECULE,a.setTag(i.TAGS.UNITS,t),"separator"===t){if(!e)throw new Error("Notation 'separator' requires separator value.");a.setTag("separator",e)}a.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const l=n.getTag("aligned");l&&a.setTag("aligned",l);const h=n.getTag("alphabet");h&&a.setTag("alphabet",h);let c=n.getTag(".alphabetSize");c&&a.setTag(".alphabetSize",c);const u=n.getTag(".alphabetIsMultichar");return void 0!==u&&a.setTag(".alphabetIsMultichar",u),"helm"==t&&(c=this.getAlphabetSize().toString(),a.setTag(".alphabetSize",c)),a}static getNewColumn(t){const e=new l(t),n=e.notation;return e.getNewColumn(n)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!l.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const s=i.Column.fromList("string",e,new Array(t).fill(""));return s.semType=i.SEMTYPE.MACROMOLECULE,s.setTag(i.TAGS.UNITS,n),s}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return r.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return r.U.LEVENSHTEIN;case"PT":return r.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return r.o[this.getDistanceFunctionName()]()}checkHelmCompatibility(){return t=this,e=void 0,i=function*(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(yield(0,a.JN)()).getBioLib().getMonomerNamesByType("PEPTIDE".toString()),e=new Set(t),n=(0,o.Ar)(this.separator);for(const t of this.column.categories){const i=n(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0},new((n=void 0)||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}));var t,e,n,i}constructor(t){this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?l._defaultGapSymbolsDict.FASTA:this.isHelm()?l._defaultGapSymbolsDict.HELM:l._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())l.setUnitsToFastaColumn(this.column);else if(this.isSeparator()){const e=t.getTag("separator");l.setUnitsToSeparatorColumn(this.column,e)}else{if(!this.isHelm())throw new Error(`Unexpected units 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n=t.toString();if(n.length<=e)return n;let i=t.toFixed(e);if(i.length>e&&(i=t.toFixed(Math.max(0,e-(i.length-e)))),i.length<=e&&!i.startsWith("0.000")&&!i.startsWith("-0.000"))return i;let s=t.toExponential(e);return s.length>e&&(s=t.toExponential(Math.max(0,e-(s.length-e)))),s.slice(0)}function y(t,e,n){let i=n?t.rows:t.rows-1;if(e<0||e>i)throw new RangeError("Row index out of range")}function b(t,e,n){let i=n?t.columns:t.columns-1;if(e<0||e>i)throw new RangeError("Column index out of range")}function w(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.columns)throw new RangeError("vector size must be the same as the number of columns");return e}function C(t,e){if(e.to1DArray&&(e=e.to1DArray()),e.length!==t.rows)throw new RangeError("vector size must be the same as the number of rows");return e}function S(t,e,n,i,s){if(5!==arguments.length)throw new RangeError("expected 4 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s=t.get(i,n)/t.get(e,n);t.set(i,n,0);for(let o=n+1;o<t.columns;o++)t.set(i,o,t.get(i,o)-t.get(e,o)*s)}e++,n++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,n=t.rows,i=n-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let s=0,o=!1;for(;s<n&&!1===o;)1===t.get(i,s)?o=!0:s++;for(let n=0;n<i;n++){let o=t.get(n,s);for(let r=s;r<e;r++){let e=t.get(n,r)-o*t.get(i,r);t.set(n,r,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:n=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(n)||n<=0)throw new TypeError("columns must be a positive integer");let i=new A(this.rows*e,this.columns*n);for(let t=0;t<e;t++)for(let e=0;e<n;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let 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Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[e]&&(t[e]=this.get(e,n));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[n]&&(t[n]=this.get(e,n));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t&&(t=this.get(e,n));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){T(this);let t=this.get(0,0),e=[0,0];for(let n=0;n<this.rows;n++)for(let i=0;i<this.columns;i++)this.get(n,i)<t&&(t=this.get(n,i),e[0]=n,e[1]=i);return e}maxRow(t){if(y(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n));return e}maxRowIndex(t){y(this,t),T(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),n[1]=i);return n}minRow(t){if(y(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n));return e}minRowIndex(t){y(this,t),T(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),n[1]=i);return n}maxColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t));return e}maxColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),n[0]=i);return n}minColumn(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t));return e}minColumnIndex(t){b(this,t),T(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),n[0]=i);return n}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let n=0;n<t;n++)e.push(this.get(n,n));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let n=0;n<this.columns;n++)e+=this.get(t,n)*this.get(t,n);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t+=this.get(e,n),this.set(e,n,t);return this}dot(t){N.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}mmul(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.columns,s=new A(e,i),o=new Float64Array(n);for(let r=0;r<i;r++){for(let e=0;e<n;e++)o[e]=t.get(e,r);for(let t=0;t<e;t++){let e=0;for(let i=0;i<n;i++)e+=this.get(t,i)*o[i];s.set(t,r,e)}}return s}strassen2x2(t){t=A.checkMatrix(t);let e=new A(2,2);const n=this.get(0,0),i=t.get(0,0),s=this.get(0,1),o=t.get(0,1),r=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(n+l)*(i+h),u=(r+l)*i,d=n*(o-h),f=l*(a-i),m=(n+s)*h,p=c+f-m+(s-l)*(a+h),g=d+m,v=u+f,y=c-u+d+(r-n)*(i+o);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,v),e.set(1,1,y),e}strassen3x3(t){t=A.checkMatrix(t);let e=new A(3,3);const n=this.get(0,0),i=this.get(0,1),s=this.get(0,2),o=this.get(1,0),r=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),d=t.get(0,1),f=t.get(0,2),m=t.get(1,0),p=t.get(1,1),g=t.get(1,2),v=t.get(2,0),y=t.get(2,1),b=t.get(2,2),w=(n-o)*(-d+p),C=(-n+o+r)*(u-d+p),S=(o+r)*(-u+d),M=n*u,x=(-n+l+h)*(u-f+g),T=(-n+l)*(f-g),N=(l+h)*(-u+f),E=(-s+h+c)*(p+v-y),I=(s-c)*(p-y),L=s*v,k=(h+c)*(-v+y),R=(-s+r+a)*(g+v-b),_=(s-a)*(g-b),G=(r+a)*(-v+b),P=M+L+i*m,O=(n+i+s-o-r-h-c)*p+C+S+M+E+L+k,F=M+x+N+(n+i+s-r-a-l-h)*g+L+R+G,W=w+r*(-u+d+m-p-g-v+b)+C+M+L+R+_,V=w+C+S+M+a*y,H=L+R+_+G+o*f,Z=M+x+T+h*(-u+f+m-p-g-v+y)+E+I+L,U=E+I+L+k+l*d,D=M+x+T+N+c*b;return e.set(0,0,P),e.set(0,1,O),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,Z),e.set(2,1,U),e.set(2,2,D),e}mmulStrassen(t){t=A.checkMatrix(t);let e=this.clone(),n=e.rows,i=e.columns,s=t.rows,o=t.columns;function r(t,e,n){let i=t.rows,s=t.columns;if(i===e&&s===n)return t;{let i=N.zeros(e,n);return i=i.setSubMatrix(t,0,0),i}}i!==s&&console.warn(`Multiplying ${n} x ${i} and ${s} x ${o} matrix: dimensions do not match.`);let a=Math.max(n,s),l=Math.max(i,o);return e=r(e,a,l),function t(e,n,i,s){if(i<=512||s<=512)return e.mmul(n);i%2==1&&s%2==1?(e=r(e,i+1,s+1),n=r(n,i+1,s+1)):i%2==1?(e=r(e,i+1,s),n=r(n,i+1,s)):s%2==1&&(e=r(e,i,s+1),n=r(n,i,s+1));let o=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,o-1,0,a-1),h=n.subMatrix(0,o-1,0,a-1),c=e.subMatrix(0,o-1,a,e.columns-1),u=n.subMatrix(0,o-1,a,n.columns-1),d=e.subMatrix(o,e.rows-1,0,a-1),f=n.subMatrix(o,n.rows-1,0,a-1),m=e.subMatrix(o,e.rows-1,a,e.columns-1),p=n.subMatrix(o,n.rows-1,a,n.columns-1),g=t(N.add(l,m),N.add(h,p),o,a),v=t(N.add(d,m),h,o,a),y=t(l,N.sub(u,p),o,a),b=t(m,N.sub(f,h),o,a),w=t(N.add(l,c),p,o,a),C=t(N.sub(d,l),N.add(h,u),o,a),S=t(N.sub(c,m),N.add(f,p),o,a),M=N.add(g,b);M.sub(w),M.add(S);let x=N.add(y,w),T=N.add(v,b),E=N.sub(g,v);E.add(y),E.add(C);let A=N.zeros(2*M.rows,2*M.columns);return A=A.setSubMatrix(M,0,0),A=A.setSubMatrix(x,M.rows,0),A=A.setSubMatrix(T,0,M.columns),A=A.setSubMatrix(E,M.rows,M.columns),A.subMatrix(0,i-1,0,s-1)}(e,t=r(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.rows;t++){const s=this.getRow(t);s.length>0&&d(s,{min:e,max:n,output:s}),i.setRow(t,s)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.columns;t++){const s=this.getColumn(t);s.length&&d(s,{min:e,max:n,output:s}),i.setColumn(t,s)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let n=0;n<t;n++){let t=this.get(e,n),i=this.get(e,this.columns-1-n);this.set(e,n,i),this.set(e,this.columns-1-n,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let n=0;n<t;n++){let t=this.get(n,e),i=this.get(this.rows-1-n,e);this.set(n,e,i),this.set(this.rows-1-n,e,t)}return this}kroneckerProduct(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.rows,s=t.columns,o=new A(e*i,n*s);for(let r=0;r<e;r++)for(let e=0;e<n;e++)for(let n=0;n<i;n++)for(let a=0;a<s;a++)o.set(i*r+n,s*e+a,this.get(r,e)*t.get(n,a));return o}kroneckerSum(t){if(t=A.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,n=t.rows,i=this.kroneckerProduct(A.eye(n,n)),s=A.eye(e,e).kroneckerProduct(t);return i.add(s)}transpose(){let t=new A(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(n,e,this.get(e,n));return t}sortRows(t=E){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=E){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,n,i){S(this,t,e,n,i);let s=new A(e-t+1,i-n+1);for(let o=t;o<=e;o++)for(let e=n;e<=i;e++)s.set(o-t,e-n,this.get(o,e));return s}subMatrixRow(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.columns-1),e>n||e<0||e>=this.columns||n<0||n>=this.columns)throw new RangeError("Argument out of range");let i=new A(t.length,n-e+1);for(let s=0;s<t.length;s++)for(let o=e;o<=n;o++){if(t[s]<0||t[s]>=this.rows)throw new RangeError(`Row index out of range: ${t[s]}`);i.set(s,o-e,this.get(t[s],o))}return i}subMatrixColumn(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.rows-1),e>n||e<0||e>=this.rows||n<0||n>=this.rows)throw new RangeError("Argument out of range");let i=new A(n-e+1,t.length);for(let s=0;s<t.length;s++)for(let o=e;o<=n;o++){if(t[s]<0||t[s]>=this.columns)throw new RangeError(`Column index out of range: ${t[s]}`);i.set(o-e,s,this.get(o,t[s]))}return i}setSubMatrix(t,e,n){if((t=A.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,n,n+t.columns-1);for(let i=0;i<t.rows;i++)for(let s=0;s<t.columns;s++)this.set(e+i,n+s,t.get(i,s));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let n=new A(t.length,e.length);for(let i=0;i<t.length;i++){let s=t[i];for(let t=0;t<e.length;t++){let o=e[t];n.set(i,t,this.get(s,o))}}return n}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let n=0;n<t;n++)e+=this.get(n,n);return e}clone(){let t=new A(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(e,n,this.get(e,n));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]+=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]+=t.get(n,i);return e}(this);case void 0:return function(t){let e=0;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e+=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]*=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]*=t.get(n,i);return e}(this);case void 0:return function(t){let e=1;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e*=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:n=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof n)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,o=[];for(let r=0;r<i;r++){let i=0,a=0,l=0;for(let e=0;e<s;e++)l=t.get(r,e)-n[r],i+=l,a+=l*l;e?o.push((a-i*i/s)/(s-1)):o.push((a-i*i/s)/s)}return o}(this,n,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,o=[];for(let r=0;r<s;r++){let s=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,r)-n[r],s+=l,a+=l*l;e?o.push((a-s*s/i)/(i-1)):o.push((a-s*s/i)/i)}return o}(this,n,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,n){const i=t.rows,s=t.columns,o=i*s;let r=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<s;i++)l=t.get(e,i)-n,r+=l,a+=l*l;return e?(a-r*r/o)/(o-1):(a-r*r/o)/o}(this,n,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const n=this.variance(t,e);if(void 0===t)return Math.sqrt(n);for(let t=0;t<n.length;t++)n[t]=Math.sqrt(n[t]);return n}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:n=this.mean(t)}=e;switch(t){case"row":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[n])}(this,n),this;case"column":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[i])}(this,n),this;case void 0:if("number"!=typeof n)throw new TypeError("center must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let n=e.scale;switch(t){case"row":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.rows;n++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(n,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[n])}(this,n),this;case"column":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.columns;n++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,n),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[i])}(this,n),this;case void 0:if(void 0===n)n=function(t){const e=t.size-1;let n=0;for(let i=0;i<t.columns;i++)for(let s=0;s<t.rows;s++)n+=Math.pow(t.get(s,i),2)/e;return Math.sqrt(n)}(this);else if("number"!=typeof n)throw new TypeError("scale must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function E(t,e){return t-e}N.prototype.klass="Matrix","undefined"!=typeof Symbol&&(N.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),N.random=N.rand,N.randomInt=N.randInt,N.diagonal=N.diag,N.prototype.diagonal=N.prototype.diag,N.identity=N.eye,N.prototype.negate=N.prototype.neg,N.prototype.tensorProduct=N.prototype.kroneckerProduct;class A extends N{constructor(t,e){if(super(),A.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let n=0;n<t;n++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const n=t;if("number"!=typeof(e=(t=n.length)?n[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(n[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!n[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(n[i]))}}}this.rows=t,this.columns=e}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}removeRow(t){return y(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),y(this,t,!0),e=Float64Array.from(w(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){b(this,t);for(let e=0;e<this.rows;e++){const n=new Float64Array(this.columns-1);for(let i=0;i<t;i++)n[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)n[i-1]=this.data[e][i];this.data[e]=n}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),b(this,t,!0),e=C(this,e);for(let n=0;n<this.rows;n++){const i=new Float64Array(this.columns+1);let s=0;for(;s<t;s++)i[s]=this.data[n][s];for(i[s++]=e[n];s<this.columns+1;s++)i[s]=this.data[n][s-1];this.data[n]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t.get(e,n));return this},t.add=function(t,n){return new e(t).add(n)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t.get(e,n));return this},t.sub=function(t,n){return new e(t).sub(n)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t.get(e,n));return this},t.mul=function(t,n){return new e(t).mul(n)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t.get(e,n));return this},t.div=function(t,n){return new e(t).div(n)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t.get(e,n));return this},t.mod=function(t,n){return new e(t).mod(n)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t.get(e,n));return this},t.and=function(t,n){return new e(t).and(n)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t.get(e,n));return this},t.or=function(t,n){return new e(t).or(n)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t.get(e,n));return this},t.xor=function(t,n){return new e(t).xor(n)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t.get(e,n));return this},t.leftShift=function(t,n){return new e(t).leftShift(n)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t.get(e,n));return this},t.signPropagatingRightShift=function(t,n){return new e(t).signPropagatingRightShift(n)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t.get(e,n));return this},t.rightShift=function(t,n){return new e(t).rightShift(n)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,n){return new e(t).pow(n)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t.get(e,n)));return this}}(N,A);class I extends N{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,n,i,s,o,r,a,l,h,c=(t=I.checkMatrix(t)).clone(),u=c.rows,d=c.columns,f=new Float64Array(u),m=1;for(e=0;e<u;e++)f[e]=e;for(l=new Float64Array(u),n=0;n<d;n++){for(e=0;e<u;e++)l[e]=c.get(e,n);for(e=0;e<u;e++){for(h=Math.min(e,n),o=0,i=0;i<h;i++)o+=c.get(e,i)*l[i];l[e]-=o,c.set(e,n,l[e])}for(s=n,e=n+1;e<u;e++)Math.abs(l[e])>Math.abs(l[s])&&(s=e);if(s!==n){for(i=0;i<d;i++)r=c.get(s,i),c.set(s,i,c.get(n,i)),c.set(n,i,r);a=f[s],f[s]=f[n],f[n]=a,m=-m}if(n<u&&0!==c.get(n,n))for(e=n+1;e<u;e++)c.set(e,n,c.get(e,n)/c.get(n,n))}this.LU=c,this.pivotVector=f,this.pivotSign=m}isSingular(){let t=this.LU,e=t.columns;for(let n=0;n<e;n++)if(0===t.get(n,n))return!0;return!1}solve(t){t=A.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let n,i,s,o=t.columns,r=t.subMatrixRow(this.pivotVector,0,o-1),a=e.columns;for(s=0;s<a;s++)for(n=s+1;n<a;n++)for(i=0;i<o;i++)r.set(n,i,r.get(n,i)-r.get(s,i)*e.get(n,s));for(s=a-1;s>=0;s--){for(i=0;i<o;i++)r.set(s,i,r.get(s,i)/e.get(s,s));for(n=0;n<s;n++)for(i=0;i<o;i++)r.set(n,i,r.get(n,i)-r.get(s,i)*e.get(n,s))}return r}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,n=t.columns;for(let i=0;i<n;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s>e?i.set(s,e,t.get(s,e)):s===e?i.set(s,e,1):i.set(s,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s<=e?i.set(s,e,t.get(s,e)):i.set(s,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function k(t,e){let n=0;return Math.abs(t)>Math.abs(e)?(n=e/t,Math.abs(t)*Math.sqrt(1+n*n)):0!==e?(n=t/e,Math.abs(e)*Math.sqrt(1+n*n)):0}class R{constructor(t){let e,n,i,s,o=(t=I.checkMatrix(t)).clone(),r=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<r;e++)t=k(t,o.get(e,i));if(0!==t){for(o.get(i,i)<0&&(t=-t),e=i;e<r;e++)o.set(e,i,o.get(e,i)/t);for(o.set(i,i,o.get(i,i)+1),n=i+1;n<a;n++){for(s=0,e=i;e<r;e++)s+=o.get(e,i)*o.get(e,n);for(s=-s/o.get(i,i),e=i;e<r;e++)o.set(e,n,o.get(e,n)+s*o.get(e,i))}}l[i]=-t}this.QR=o,this.Rdiag=l}solve(t){t=A.checkMatrix(t);let e=this.QR,n=e.rows;if(t.rows!==n)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,s,o,r,a=t.columns,l=t.clone(),h=e.columns;for(o=0;o<h;o++)for(s=0;s<a;s++){for(r=0,i=o;i<n;i++)r+=e.get(i,o)*l.get(i,s);for(r=-r/e.get(o,o),i=o;i<n;i++)l.set(i,s,l.get(i,s)+r*e.get(i,o))}for(o=h-1;o>=0;o--){for(s=0;s<a;s++)l.set(o,s,l.get(o,s)/this.Rdiag[o]);for(i=0;i<o;i++)for(s=0;s<a;s++)l.set(i,s,l.get(i,s)-l.get(o,s)*e.get(i,o))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,n=this.QR,i=n.columns,s=new A(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?s.set(t,e,n.get(t,e)):t===e?s.set(t,e,this.Rdiag[t]):s.set(t,e,0);return s}get orthogonalMatrix(){let t,e,n,i,s=this.QR,o=s.rows,r=s.columns,a=new A(o,r);for(n=r-1;n>=0;n--){for(t=0;t<o;t++)a.set(t,n,0);for(a.set(n,n,1),e=n;e<r;e++)if(0!==s.get(n,n)){for(i=0,t=n;t<o;t++)i+=s.get(t,n)*a.get(t,e);for(i=-i/s.get(n,n),t=n;t<o;t++)a.set(t,e,a.get(t,e)+i*s.get(t,n))}}return a}}class _{constructor(t,e={}){if((t=I.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let n=t.rows,i=t.columns;const{computeLeftSingularVectors:s=!0,computeRightSingularVectors:o=!0,autoTranspose:r=!1}=e;let a,l=Boolean(s),h=Boolean(o),c=!1;if(n<i)if(r){a=t.transpose(),n=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(n,i),d=Math.min(n+1,i),f=new Float64Array(d),m=new A(n,u),p=new A(i,i),g=new Float64Array(i),v=new Float64Array(n),y=new Float64Array(d);for(let t=0;t<d;t++)y[t]=t;let b=Math.min(n-1,i),w=Math.max(0,Math.min(i-2,n)),C=Math.max(b,w);for(let t=0;t<C;t++){if(t<b){f[t]=0;for(let e=t;e<n;e++)f[t]=k(f[t],a.get(e,t));if(0!==f[t]){a.get(t,t)<0&&(f[t]=-f[t]);for(let e=t;e<n;e++)a.set(e,t,a.get(e,t)/f[t]);a.set(t,t,a.get(t,t)+1)}f[t]=-f[t]}for(let e=t+1;e<i;e++){if(t<b&&0!==f[t]){let i=0;for(let s=t;s<n;s++)i+=a.get(s,t)*a.get(s,e);i=-i/a.get(t,t);for(let s=t;s<n;s++)a.set(s,e,a.get(s,e)+i*a.get(s,t))}g[e]=a.get(t,e)}if(l&&t<b)for(let e=t;e<n;e++)m.set(e,t,a.get(e,t));if(t<w){g[t]=0;for(let e=t+1;e<i;e++)g[t]=k(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<n&&0!==g[t]){for(let e=t+1;e<n;e++)v[e]=0;for(let e=t+1;e<n;e++)for(let n=t+1;n<i;n++)v[e]+=g[n]*a.get(e,n);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let s=t+1;s<n;s++)a.set(s,e,a.get(s,e)+i*v[s])}}if(h)for(let e=t+1;e<i;e++)p.set(e,t,g[e])}}let S=Math.min(i,n+1);if(b<i&&(f[b]=a.get(b,b)),n<S&&(f[S-1]=0),w+1<S&&(g[w]=a.get(w,S-1)),g[S-1]=0,l){for(let t=b;t<u;t++){for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}for(let t=b-1;t>=0;t--)if(0!==f[t]){for(let e=t+1;e<u;e++){let i=0;for(let s=t;s<n;s++)i+=m.get(s,t)*m.get(s,e);i=-i/m.get(t,t);for(let s=t;s<n;s++)m.set(s,e,m.get(s,e)+i*m.get(s,t))}for(let e=t;e<n;e++)m.set(e,t,-m.get(e,t));m.set(t,t,1+m.get(t,t));for(let e=0;e<t-1;e++)m.set(e,t,0)}else{for(let e=0;e<n;e++)m.set(e,t,0);m.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<w&&0!==g[t])for(let e=t+1;e<i;e++){let n=0;for(let s=t+1;s<i;s++)n+=p.get(s,t)*p.get(s,e);n=-n/p.get(t+1,t);for(let s=t+1;s<i;s++)p.set(s,e,p.get(s,e)+n*p.get(s,t))}for(let e=0;e<i;e++)p.set(e,t,0);p.set(t,t,1)}let M=S-1,x=0,T=Number.EPSILON;for(;S>0;){let 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i=n(4469),s=n(3870),o=n(976),r=n(585);const a=r.GU;var l;!function(t){t.MSA="MSA",t.classic="classic"}(l||(l={}));const h=(t,e,n,i,s,o,r="rgb(100,100,100)",h=0,c=!1,u=1,d="",f=!1,m=l.classic,p={},g=0,v=null,y=[],b=null)=>{var w,C,S;s.textAlign="start";let M=o.substring(0),x=f?"":d;m===l.MSA&&(x="");let T=!0,N=!0,E="difference";null!=v&&null!=v.cell.column&&(T=null===(w=v.cell.column.temp["color-code"])||void 0===w||w,N=null===(C=v.cell.column.temp["compare-with-current"])||void 0===C||C,E=null!==(S=v.cell.column.temp["highlight-difference"])&&void 0!==S?S:"difference");const A=y[g];N&&y.length>0&&"difference"===E&&(u=M==A?.3:u),N&&y.length>0&&"equal"===E&&(u=M!=A?.3:u),null!=b&&(M=a(M,b));let I=s.measureText(M+x),L=s.measureText(M).width,k=s.measureText(M).width;const R=i/2-(I.fontBoundingBoxAscent+I.fontBoundingBoxDescent)/2+1;function _(n,i){const 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r=t.cell.column.temp,a=r["bio-sum-maxLengthWords"],l=r["bio-maxIndex"],h=e.offsetX-t.gridColumn.left+(t.gridColumn.left-t.bounds.x);let c=0,d=l,f=!1;a[l+1]=h+1;let m=0;if(h>a[0])for(;!f;)m=Math.floor((d+c)/2),h>=a[m]&&h<=a[m+1]?(c=m,f=!0):h<a[m]?d=m-1:h>a[m+1]&&(c=m+1),c==d&&(f=!0);c=h>=a[c]?c+1:c;const p=null!==(n=t.cell.column.getTag("separator"))&&void 0!==n?n:"",g=(0,u.vU)("separator",p)(t.cell.value);(null!==(o=null===(i=g[c])||void 0===i?void 0:i.length)&&void 0!==o?o:0)>0?s.tooltip.show(s.div(g[c]),e.x+16,e.y+16):s.tooltip.hide()}render(t,e,n,i,s,r,a){var c;const d=-1!==r.gridRow?r.grid:null,g=r.cell,v=r.cell.column.getTag("alphabet");i=p(d,t,e,i),t.save(),t.beginPath(),t.rect(e,n,i,s),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=r.cell.column.getTag(o.TAGS.UNITS),b=r.cell.column.getTag("aligned"),w=(0,u.py)(v),C=null!==(c=r.cell.column.getTag("separator"))&&void 0!==c?c:"",S=i/5,M=(0,u.vU)(y,C,S),x=r.cell.column.temp,T=x["reference-sequence"],N=x["current-word"],E=x["monomer-width"],A=M(null!=T&&""!=T?T:null!=N?N:"");let I=5,L=0,k=8;"short"===(null!=E?E:"short")&&(I=12,k=1);let R={};if(r.cell.column.getTag(".calculatedCellRender")!==S.toString()){let t=0;for(;t<Math.min(r.cell.column.length,100);)M(r.cell.column.get(t)).forEach(((t,e)=>{var n;const i=7*m(t,k).length+I;i>(null!==(n=R[e])&&void 0!==n?n:0)&&(R[e]=i),e>L&&(L=e)})),t+=1;const e=21;for(let t=0;t<=L;t++){R[t]<e&&(R[t]=e);const n={};n[0]=R[0];for(let t=1;t<=L;t++)n[t]=n[t-1]+R[t];x["bio-sum-maxLengthWords"]=n,x["bio-maxIndex"]=L,x["bio-maxLengthWords"]=R,r.cell.column.setTag(".calculatedCellRender",S.toString())}}else R=x["bio-maxLengthWords"];const _=M(g.value);let G=e,P=f,O=l.classic;b&&b.includes("MSA")&&"separator"==y&&(O=l.MSA),_.every(((e,o)=>{P=w.get(e),t.fillStyle=f;const a=o===_.length-1;return G=h(G,n,i,s,t,e,P,0,!0,1,C,a,O,R,o,r,A,k),50<=i})),t.restore()}}class y extends o.GridCellRenderer{get name(){return c.Of.MONOMER}get cellType(){return c.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 30}render(t,e,n,i,s,o,r){t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,u.py)(o.cell.column.getTag("alphabet")),l=o.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,u.GU)(l,3),e+i/2,n+s/2,i)}}class b extends o.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return c.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,s,r,a){var l;const h=r.grid,c=null!==(l=r.cell.value)&&void 0!==l?l:"",d=r.tableColumn.tags.separator,f=r.tableColumn.tags[o.TAGS.UNITS];i=p(h,t,e,i);const[m,g]=c.split("#"),v=(0,u.vU)(f,d);w(t,e,n,i,s,v(m),v(g),f)}}function w(t,e,n,i,s,o,r,a,l,c){if(o.length!==r.length){const t=function(t,e){let n=0,i=0;const s=t.length>e.length?t:e;let o=t.length>e.length?e:t;for(let 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a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(g([t]).join("")).width,u=l.measureText(g([e]).join("")).width,d=Math.max(c,u);return a.height=r,a.width=d+4,l.font="12px monospace",l.textBaseline="top",h(0,s-o,d,r,l,t,n,0,!0),h(0,s+o,d,r,l,e,i,0,!0),a}var S,M=n(701),x=n(2121),T=n(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(S||(S={})),new class{constructor(){this.regionTypes=[S.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.positionWidth=16,this.positionHeight=T.ES.Entropy}};var N=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};const E=S;class A extends o.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.regionTypes=this.stringList("regionTypes",[E.CDR],{choices:Object.values(E).filter((t=>t!=E.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16),this.positionHeight=this.string("positionHeight",T.ES.Entropy,{choices:Object.keys(T.ES)})}init(){return N(this,void 0,void 0,(function*(){this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.subs.push(M.fromEvent(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}))}onTableAttached(){const t=Object.create(null,{onTableAttached:{get:()=>super.onTableAttached}});return N(this,void 0,void 0,(function*(){const e=t.onTableAttached.bind(this);this.viewPromise=this.viewPromise.then((()=>N(this,void 0,void 0,(function*(){e(),this.viewed||(yield this.buildView("onTableAttached"),this.viewed=!0)}))))}))}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){console.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((()=>N(this,void 0,void 0,(function*(){this.viewed&&(yield this.destroyView("setData"),this.viewed=!1)})))),this.regions=e,this.dataFrame=t,this.viewPromise=this.viewPromise.then((()=>N(this,void 0,void 0,(function*(){this.viewed||(yield this.buildView("setData"),this.viewed=!0)}))))}detach(){const t=super.detach.bind(this);this.viewPromise=this.viewPromise.then((()=>N(this,void 0,void 0,(function*(){this.viewed&&(yield this.destroyView("detach"),this.viewed=!1),t()}))))}destroyView(t){return N(this,void 0,void 0,(function*(){console.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}))}buildView(t){return N(this,void 0,void 0,(function*(){console.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort();this.logos=[];for(let t=0;t<n.length;t++){const i={};for(const s of this.chains){const o=e.find((e=>e.order==n[t]&&e.chain==s));i[s]=yield this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight})}this.logos[t]=i}this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",s.tooltip.bind(this.filterSourceInput.root,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),console.debug("Bio: VdRegionsViewer.buildView() end")}))}calcSize(){const t=(this.root.clientHeight-54)/this.chains.length,e=Math.min(t,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));for(let t=0;t<this.logos.length;t++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[t][i].root.style.height=`${e}px`}}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?T.Ct.Selected:T.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[e][i].setOptions({[x.bo.filterSource]:t})}}}var I=n(9017),L=n(850),k=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function R(t,e,i,s){return k(this,void 0,void 0,(function*(){const o=yield function(t,e,i){return new Promise((function(s,o){const r=new Worker(new URL(n.p+n.u(457),n.b));r.postMessage({columnData:t.data,method:e,measure:t.metric,options:i}),r.onmessage=({data:{error:t,distance:e,embedding:n}})=>{t?o(t):s({distance:e,embedding:n})}}))}({data:t,metric:i},e,s);return o.embedding=o.embedding.map((t=>(0,L.Fv)(t))),o}))}var _=n(7983),G=n(499),P=n(7767),O=n(489),F=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function W(t){return F(this,void 0,void 0,(function*(){const e=new P.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let n=O.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert("fasta");i=t.toList(),n=new G.C(t).getDistanceFunctionName()}else n=e.getDistanceFunctionName();const s=yield R(i,t.methodName,n,t.options),r=t.embedAxesNames.map(((t,e)=>o.Column.fromFloat32Array(t,s.embedding[e])));return{distance:s.distance,coordinates:new o.ColumnList(r)}}return yield function(t){return F(this,void 0,void 0,(function*(){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&(yield(0,_.HV)(t.seqCol,!1)),yield i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}))}(t)}))}function V(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}var H=n(5697),Z=n(3379),U=n.n(Z),D=n(7795),B=n.n(D),Y=n(569),z=n.n(Y),X=n(3565),q=n.n(X),K=n(9216),j=n.n(K),$=n(4589),J=n.n($),Q=n(9414),tt={};tt.styleTagTransform=J(),tt.setAttributes=q(),tt.insert=z().bind(null,"head"),tt.domAPI=B(),tt.insertStyleElement=j(),U()(Q.Z,tt),Q.Z&&Q.Z.locals&&Q.Z.locals;var et=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};let nt=0;const it="cliffsDf",st=new M.Subject,ot="act_diff",rt="sali",at="sim",lt="line_index",ht=["1_seq","2_seq"],ct="filterCliffs";function ut(t,e,n){const i=e.getBoundingClientRect(),s=t.clientX-i.left,o=t.clientY-i.top;let r=null,a=0;for(const t of n){const e=Math.abs(Math.hypot(t.a[0]-s,t.a[1]-o)+Math.hypot(t.b[0]-s,t.b[1]-o)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,r=t)}return r}var dt=n(1040),ft=(n(7861),function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))});function mt(t,e,n,s,r){return ft(this,void 0,void 0,(function*(){e.version!==e.temp["last-invalidated-version"]&&(yield(0,_.HV)(e,!1));const n=o.DataFrame.create(e.length);return n.columns.addNewString(s).init((t=>e.temp["monomeric-mols"].get(t))),yield i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:n,colName:s,simArr:r})}))}function pt(t){const e=s.divH([]),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.line.mols.forEach(((n,i)=>{const o=s.divText(t.activityCol.get(n).toFixed(2));o.style.display="flex",o.style.justifyContent="left",o.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),o]))})),e}function gt(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2),i=new Array(2);t.line.mols.forEach(((e,s)=>{n[s]=t.seqCol.get(e),i[s]=t.activityCol.get(e)}));const r={},a=t.seqCol.getTag(o.TAGS.UNITS),l=t.seqCol.getTag("separator"),h=(0,u.vU)(a,l),c=yt(h(n[0]),h(n[1]),a,r);return e.append(s.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(bt(r)),e.append(vt("Activity delta",Math.abs(i[0]-i[1]))),e.append(vt("Cliff",t.sali)),e}function vt(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function yt(t,e,n,i){const s=document.createElement("canvas"),o=s.getContext("2d");return s.height=30,w(o,0,0,0,30,t,e,n,!0,i),s}function bt(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function wt(t,e){const n=o.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(o.TAGS.UNITS,t.col(e[0]).getTag(o.TAGS.UNITS)),n.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}var Ct=n(4004),St=n(7228),Mt=n(1731),xt=n(5226);n(9133);var Tt=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class Nt extends o.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[o.TAGS.UNITS,"aligned","separator","alphabet"],this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",H.kg[0],{choices:H.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}onTableAttached(){var t;return Tt(this,void 0,void 0,(function*(){if(this.init(),this.dataFrame){this.subs.push(o.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>Tt(this,void 0,void 0,(function*(){return yield this.render()})))));const e="diversity"!==this.name;this.subs.push(o.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>Tt(this,void 0,void 0,(function*(){return yield this.render(e)}))))),this.subs.push(o.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>Tt(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.subs.push(o.debounce(s.onSizeChanged(this.root),50).subscribe((t=>Tt(this,void 0,void 0,(function*(){return yield this.render(!1)}))))),this.moleculeColumn=this.dataFrame.columns.bySemType(o.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=null===(t=this.moleculeColumn)||void 0===t?void 0:t.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}yield this.render()}))}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===o.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){return Tt(this,void 0,void 0,(function*(){}))}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==o.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Et=n(7241),At=n(4293),It=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};function Lt(t){return It(this,void 0,void 0,(function*(){const e=t.toList(),i=new Worker(new URL(n.p+n.u(925),n.b));if(t.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=new G.C(t).getDistanceFunctionName();return i.postMessage({values:e,fnName:s}),new Promise(((t,e)=>{i.onmessage=({data:{error:n,distanceMatrixData:s}})=>{i.terminate(),n?e(n):t(s)}}))}))}function kt(t){return(e,n)=>{const i=(e,n)=>t*e+n-Math.floor((e+2)*(e+1)/2);return e<=n?i(e,n):i(n,e)}}var Rt=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class _t extends Nt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new M.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}render(t=!0){var e;return Rt(this,void 0,void 0,(function*(){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=new G.C(this.moleculeColumn);yield t.isFasta()?this.computeByMM():this.computeByChem();const n=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=o.Column.string(n,this.idxs.length).init((t=>{var e,n;return null===(e=this.moleculeColumn)||void 0===e?void 0:e.get(null===(n=this.idxs)||void 0===n?void 0:n.get(t))})),this.molCol.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=o.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const r=s.plot.grid();r.col("indexes").visible=!1;const a=null===(e=this.idxs)||void 0===e?void 0:e.getRawData().findIndex((t=>t==this.targetMoleculeIdx));r.cell("score",a).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,At.Y)(this.root,r.root),this.computeCompleted.next(!0)}}))}computeByChem(){return Rt(this,void 0,void 0,(function*(){const t=yield(0,Et.D)(this.moleculeColumn),e=(o.DataFrame.fromColumns([t]),yield i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}))}computeByMM(){return Rt(this,void 0,void 0,(function*(){this.distanceMatrixComputed||(this.mmDistanceMatrix=yield Lt(this.moleculeColumn),this.distanceMatrixComputed=!0);const t=this.moleculeColumn.length,e=kt(t),n=Array(t).fill(0).map(((t,n)=>({idx:n,score:n===this.targetMoleculeIdx?1:1-this.mmDistanceMatrix[e(this.targetMoleculeIdx,n)]})));n.sort(((t,e)=>e.score-t.score));const i=Math.min(this.limit,t),s=n.slice(0,i);this.idxs=o.Column.int("indexes",i).init((t=>s[t].idx)),this.scores=o.Column.float("score",i).init((t=>s[t].score))}))}createPropertyPanel(t){var e;const n=s.div(),r={},a=null===(e=this.molCol)||void 0===e?void 0:e.name,l=t.col(a).getTag(o.TAGS.UNITS),h=t.col(a).getTag("separator"),c=(0,u.vU)(l,h),d=c(this.moleculeColumn.get(this.targetMoleculeIdx)),f=c(t.get(a,t.currentRowIdx)),m=yt(d,f,l,r);n.append(s.div(m,{style:{width:"300px",overflow:"scroll"}})),d.length!==f.length&&n.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${d.length} monomers`),s.divText(`selected: ${f.length} monomers`)],{style:{paddingBottom:"10px"}})),n.append(bt(r));const p=s.accordion(),g=s.element("i");g.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([g,s.label("Similarity search")])),p.addPane("Differences",(()=>n),!0),i.shell.o=p.root}}var Gt=n(8518),Pt=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class Ot extends Nt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new M.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}render(t=!0){return Pt(this,void 0,void 0,(function*(){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=new G.C(this.moleculeColumn);yield t.isFasta()?this.computeByMM():this.computeByChem();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=o.Column.string(e,this.renderMolIds.length).init((t=>{var e;return null===(e=this.moleculeColumn)||void 0===e?void 0:e.get(this.renderMolIds[t])}));n.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>n.setTag(t,this.moleculeColumn.getTag(t))));const i=o.DataFrame.fromColumns([n]);(0,At.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}))}computeByChem(){return Pt(this,void 0,void 0,(function*(){const t=yield(0,Et.D)(this.moleculeColumn);o.DataFrame.fromColumns([t]),this.renderMolIds=yield i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}))}computeByMM(){return Pt(this,void 0,void 0,(function*(){const t=yield Lt(this.moleculeColumn),e=this.moleculeColumn.length,n=kt(e);this.renderMolIds=(0,Gt.L)(e,Math.min(e,this.limit),((e,i)=>t[n(e,i)]))}))}}var Ft=n(9943),Wt=n(4413),Vt=n(1061),Ht=n(1345),Zt=n(116);const Ut={[o.SEMTYPE.MOLECULE]:"Molecules",[o.SEMTYPE.MACROMOLECULE]:"Sequences"};class Dt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}constructor(t){this.methodSettingsDiv=s.inputs([]),this.methodsParams={[Zt.AL.UMAP]:new Zt.bD,[Zt.AL.T_SNE]:new Zt.aP},this.tableInput=s.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=s.columnInput(Ut[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),this.molColInputRoot=this.molColInput.root,this.methodInput=s.choiceInput("Method",Zt.AL.UMAP,[Zt.AL.UMAP,Zt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);let e=!1;this.similarityMetricInput=s.choiceInput("Similarity",dt.gk.Tanimoto,H.Rt)}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],o=s.floatInput(i.uiName,i.value,(()=>{i.value=o.value}));s.tooltip.bind(o.root,i.tooltip),t.append(o.root)})),t}onTableInputChanged(t){this.molColInput=s.columnInput(Ut[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),s.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Bt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=s.boolInput("Plot Embeddings",!0),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Yt extends Dt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.tableInput.value.col(this.activitiesDataframe?this.activitiesInput.value.name:""),similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesDataframe=e.length?o.DataFrame.fromColumns(e):"",this.activitiesInput=s.columnInput("Activities",this.activitiesDataframe,this.activitiesDataframe?this.activitiesDataframe.columns.byIndex(0):""),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.intInput("Similarity cutoff",80),s.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesDataframe=e.length?o.DataFrame.fromColumns(e):"",this.activitiesInput=s.columnInput("Activities",this.activitiesDataframe,this.activitiesDataframe?this.activitiesDataframe.columns.byIndex(0):""),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var zt=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class Xt{constructor(t,e,n=!1,i){var o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._progress.max=0,this._progress.value=1,Xt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){var t,e,n;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const s=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,o.DOCK_TYPE.FILL,s,""),(null===(e=null===(t=s.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(n=s.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return zt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const r=n,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,r.offsetTop-this._mainHeader.offsetHeight),yield this._countdown(n,i,a),yield(0,Vt.gw)(a);const l=s.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return zt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return zt(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas 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G.C(t),!0))),n=e=>ye(this,void 0,void 0,(function*(){if(!(0,ge.n)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(n,o.DOCK_TYPE.DOWN,null,"Composition analysis",.25)}));let r=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>new G.C(t).isMsa())),o=s.choiceInput("Column",i?i.name:t[0],t);s.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(s.div([o])).onOK((()=>ye(this,void 0,void 0,(function*(){var t;const i=null!==(t=e.find((t=>t.name==o.value)))&&void 0!==t?t:null;i&&(yield n(i))})))).show()}else r=e[0];r&&(yield n(r))}else i.shell.error("Current table does not contain sequences")}))}function De(t){return ye(this,void 0,void 0,(function*(){(0,St.Xk)(t)}))}function Be(t){return new xt.i(t).importFasta()}function Ye(){const t=(0,At.m)();(0,Ct.O)(t)}function ze(){return new y}function Xe(t){return ye(this,void 0,void 0,(function*(){const e=o.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(yield i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let s=0;const r=[];for(const a of n)try{const e=yield i.dapi.files.readAsText(t+a.fullPath),n=o.DataFrame.fromCsv(e);for(const t of n.columns)(yield i.functions.call("Bio:detectMacromolecule",{col:t}))===o.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(o.TAGS.UNITS)}`})}catch(t){r.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{s+=1,e.update(100*s/n.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=o.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${t}`,a}))}function qe(){const t=(0,At.m)(),e=function(t){const e=(0,r.Mj)(t),n=t=>{const e=a.columns.addNewString((t+1).toString());return i.push(e),e},i=[],s=t.length,a=o.DataFrame.create(s);for(let o=0;o<s;++o){const s=t.get(o);null!=s&&e(s).forEach(((t,e)=>{var s;((null!==(s=i[e])&&void 0!==s?s:null)||n(e)).set(o,t||"-",!1)}))}return a}(t),n=t.dataFrame;for(const i of e.columns){const e=n.columns.add(i);e.semType=c.Of.MONOMER,e.setTag(o.TAGS.CELL_RENDERER,c.Of.MONOMER),e.setTag("alphabet",t.getTag("alphabet"))}i.shell.tv.grid.invalidate()}function Ke(t){const e=(0,u.fy)(t,1,u.gP);return Object.keys(e.freq)}function je(){return new _t}function $e(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Je(){return new Ot}function Qe(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function tn(){const t=(0,At.m)();(0,_.gQ)(t)}function en(){(0,Ft.C2)()}function nn(){return new Wt.ST}function sn(){return ye(this,void 0,void 0,(function*(){yield function(){return $t(this,void 0,void 0,(function*(){let t,e;try{const n=new Xt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");yield n.step("Load DNA sequences",(()=>$t(this,void 0,void 0,(function*(){i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=yield be.files.readCsv(Jt),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}))),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(()=>$t(this,void 0,void 0,(function*(){const n=yield e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(n,o.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}))),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(()=>$t(this,void 0,void 0,(function*(){const n=yield e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(n,o.DOCK_TYPE.DOWN,null,"Diversity search",.27)}))),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(()=>$t(this,void 0,void 0,(function*(){e.currentRowIdx=3}))),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(()=>$t(this,void 0,void 0,(function*(){e.currentRowIdx=7}))),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){jt(t)}}))}()}))}function on(){return ye(this,void 0,void 0,(function*(){yield function(){return oe(this,void 0,void 0,(function*(){let t,e,n,s,r;try{const a=new Xt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");yield a.step("Load DNA sequences",(()=>oe(this,void 0,void 0,(function*(){[s,t,e]=yield Promise.all([be.files.readCsv(re),ne(),se()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}))),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(()=>oe(this,void 0,void 0,(function*(){r=yield function(t,e,n,i){return Kt(this,void 0,void 0,(function*(){let i;{const t=Object.values(qt);for(let n=0;n<t.length;n++){const i=t[n];if(!e.col(i)){const s=n==t.length-1;e.columns.add(o.Column.float(i,e.rowCount),s)}}if(e.rowCount>=1){const i=e.getCol(n).toList(),s=Date.now();be.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const o=yield R(i,"UMAP",dt.W.Levenshtein,{}),r=Date.now();be.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(r-s)/1e3} s`);for(let n=0;n<t.length;n++){const i=t[n],s=e.getCol(i),r=o.embedding[n];s.init((t=>r[t]))}const a=Date.now();be.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-r)/1e3} s`)}i=yield e.plot.fromType(o.VIEWER.SCATTER_PLOT,{xColumnName:qt.X,yColumnName:qt.Y,lassoTool:!0})}return t.dockManager.dock(i,o.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}))}(n,s,ae)}))),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(()=>oe(this,void 0,void 0,(function*(){const i=s.getCol(ae).toList(),o=te.H.calc(i,((t,e)=>Qt.T(t,e)/((t.length+e.length)/2))),r=yield t.hierarchicalClusteringByDistance(o,"ward");e.injectTreeForGrid(n.grid,r,void 0,150,void 0)}))),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(()=>oe(this,void 0,void 0,(function*(){s.selection.init((t=>[15].includes(t)))}))),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(()=>oe(this,void 0,void 0,(function*(){const t=s.getCol("sequence_id");s.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),s.currentRowIdx=27}))),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){jt(t)}}))}()}))}function rn(){return ye(this,void 0,void 0,(function*(){yield function(){return ce(this,void 0,void 0,(function*(){let t,e,n,s,r;const a=Zt.AL.UMAP;try{const l=new Xt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");yield l.step("Load DNA sequences",(()=>ce(this,void 0,void 0,(function*(){i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[n,t,e]=yield Promise.all([be.files.readCsv(ue),ne(),se()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=300,s.grid.columns.byName("is_cliff").visible=!1}))),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(()=>ce(this,void 0,void 0,(function*(){r=yield Oe(n,n.getCol("Sequence"),n.getCol("Activity"),80,a),s.dockManager.dock(r,o.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),he()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}))),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(()=>ce(this,void 0,void 0,(function*(){const i=n.getCol("sequence").toList(),o=te.H.calc(i,((t,e)=>Qt.T(t,e)/((t.length+e.length)/2))),r=yield t.hierarchicalClusteringByDistance(o,"ward");e.injectTreeForGrid(s.grid,r,void 0,150,void 0),s.grid.columns.byName("Activity").scrollIntoView()}))),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(()=>ce(this,void 0,void 0,(function*(){const t=r.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}))),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){jt(t)}}))}()}))}function an(){return ye(this,void 0,void 0,(function*(){yield function(){return de(this,void 0,void 0,(function*(){const t="HELM";let e,n,r;try{yield new Xt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(()=>de(this,void 0,void 0,(function*(){i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=yield be.files.readCsv("samples/sample_HELM.csv"),n=i.shell.addTableView(e);for(let e=0;e<n.grid.columns.length;e++){const i=n.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}))),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(()=>de(this,void 0,void 0,(function*(){const n=e.getCol(t);yield Ve(e,n)}))),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(()=>de(this,void 0,void 0,(function*(){const n=`molfile(${t})`;e.currentCell=e.cell(1,n);const i=e.currentCell.value,a=new o.chem.Sketcher(o.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),r=s.dialog().add(a).show(),yield(0,Vt.gw)(3e3),r.close()}))),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){jt(t)}}))}()}))}function ln(){return ye(this,void 0,void 0,(function*(){yield function(){return me(this,void 0,void 0,(function*(){let t,e,n,s,r,a;const l="msa(HELM)",h=Zt.AL.UMAP;try{const c=new Xt("Helm, MSA, Sequence 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representation.",delay:2e3}).step("Analyse sequence composition",(()=>me(this,void 0,void 0,(function*(){r=yield e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(r,o.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}))),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){jt(t)}}))}()}))}},9017:(t,e,n)=>{"use strict";n.d(e,{k:()=>o});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class s{constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class o{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",o="",r=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)o+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=o+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=o+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:o+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:o+i);let s=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[s][e].parentJ}return new s(n,i,r)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){let t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){let t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let s=1;s<=this.len2;s++)this.fillOne(i,s),this.dpGrid[i][s].value<=0?(this.dpGrid[i][s].value=0,this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0):0==this.dpGrid[this.dpGrid[i][s].parentI][this.dpGrid[i][s].parentJ].value&&(this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0),this.dpGrid[i][s].value>t&&(t=this.dpGrid[i][s].value,e=i,n=s);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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l)o.push(`${t}${i}`)}return"".concat(...o)}(n,i,s),a=document.createElement("a");a.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),a.setAttribute("download",`${t.dataFrame.name}.fasta`),a.click()})).show()}function d(t,e,n=c){const i=e(t);let s=0;const o=i.length,r=[];for(;s<o;){const t=i.slice(s,s+n),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");r.push(e),s+=t.length}return r}},4293:(t,e,n)=>{"use strict";n.d(e,{Y:()=>r,m:()=>o});var i=n(4469),s=n(976);function o(){const t=i.shell.t.columns.bySemType(s.SEMTYPE.MACROMOLECULE);if(null!==t)return t;i.shell.error("Current table does not contain macromolecules")}function r(t,e){t.innerHTML="",t.append(e)}},2121:(t,e,n)=>{"use strict";n.d(e,{bo:()=>m,OZ:()=>y});var i=n(4469),s=n(3870),o=n(976),r=n(6414),a=n.n(r),l=n(701),h=n(499),c=n(8447),u=n(9298);function d(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?d(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var f,m;HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new o.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},o.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class p{constructor(t=0,e=new o.Rect(0,0,0,0)){this.count=t,this.bounds=e}}class g{constructor(t,e,n={},i=0,s=0){this.pos=t,this.name=e,this.freq=n,this.rowCount=i,this.sumForHeightCalc=s}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(f||(f={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(m||(m={}));const v=u.vS;class y extends o.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){var t;return"auto"===this.positionMarginState&&!0===(null===(t=this.unitsHandler)||void 0===t?void 0:t.getAlphabetIsMultichar())||"enable"===this.positionMarginState?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.splitter=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=y.viewerCount,y.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(m.sequenceColumnName,v.sequenceColumnName,{category:f.DATA}),this.startPositionName=this.string(m.startPositionName,v.startPositionName,{category:f.DATA}),this.endPositionName=this.string(m.endPositionName,v.endPositionName,{category:f.DATA}),this.skipEmptySequences=this.bool(m.skipEmptySequences,v.skipEmptySequences,{category:f.DATA}),this.skipEmptyPositions=this.bool(m.skipEmptyPositions,v.skipEmptyPositions,{category:f.DATA}),this.shrinkEmptyTail=this.bool(m.shrinkEmptyTail,v.shrinkEmptyTail,{category:f.DATA}),this.backgroundColor=this.int(m.backgroundColor,v.backgroundColor,{category:f.STYLE}),this.positionHeight=this.string(m.positionHeight,v.positionHeight,{category:f.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(m.positionWidth,v.positionWidth,{category:f.STYLE}),this.verticalAlignment=this.string(m.verticalAlignment,v.verticalAlignment,{category:f.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(m.horizontalAlignment,v.horizontalAlignment,{category:f.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(m.fixWidth,v.fixWidth,{category:f.LAYOUT}),this.fitArea=this.bool(m.fitArea,v.fitArea,{category:f.LAYOUT}),this.minHeight=this.float(m.minHeight,v.minHeight,{category:f.LAYOUT}),this.maxHeight=this.float(m.maxHeight,v.maxHeight,{category:f.LAYOUT}),this.positionMarginState=this.string(m.positionMarginState,v.positionMarginState,{category:f.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(m.positionMargin,t,{category:f.LAYOUT,min:0,max:16}),this.filterSource=this.string(m.filterSource,v.filterSource,{category:f.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=s.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=s.canvas(),this.canvas.style.width="100%"}init(){this.initialized?console.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=s.div("No message"),this.msgHost.style.display="none",this.canvas=s.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=s.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(l.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(l.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(l.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame)if(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol){const t=this.seqCol.getTag(o.TAGS.UNITS),e=this.seqCol.getTag("separator");this.splitter=(0,c.vU)(t,e),this.unitsHandler=new h.C(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol)}else this.splitter=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null;this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...t.map((t=>null!==t?this.splitter(t).length:0))):0,n=this.seqCol.getTag(u.DX.positionNames);this.positionNames=n?n.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),n=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,n=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,n)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case m.sequenceColumnName:case m.startPositionName:case m.endPositionName:case m.filterSource:this.updateSeqCol();break;case m.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case m.fixWidth:case m.fitArea:case m.positionMargin:this.updateSlider();break;case m.shrinkEmptyTail:case m.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){super.onTableAttached();const t=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),this.updateSeqCol(),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}detach(){const t=Object.create(null,{detach:{get:()=>super.detach}});return e=this,n=void 0,s=function*(){const e=this.dataFrame?"data":"null";console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${e} ) start`),t.detach.call(this),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,console.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)},new((i=void 0)||(i=Promise))((function(t,o){function r(t){try{l(s.next(t))}catch(t){o(t)}}function a(t){try{l(s.throw(t))}catch(t){o(t)}}function l(e){var n;e.done?t(e.value):(n=e.value,n instanceof i?n:new i((function(t){t(n)}))).then(r,a)}l((s=s.apply(e,n||[])).next())}));var e,n,i,s}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,n=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),i=this.positions[n];if(null==i)return[n,null,null];const s=Object.keys(i.freq).find((n=>i.freq[n].bounds.contains(e,t.y)));return void 0===s?[n,null,null]:[n,s,i.freq[s]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const n=t.length;let i=0;for(let s=0;s<n;s++)e(t[s])||(t[i]=t[s],i++);return t.length=i,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>{var e;return(null===(e=null==t?void 0:t.freq["-"])||void 0===e?void 0:e.count)===t.rowCount}))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=new h.C(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new g(this.startPosition+t,e)}const n=this.filter.getSelectedIndexes();this.rowsMasked=n.length,this.rowsNull=0;for(const t of n){let e=this.seqCol.get(t);e||(e=this._nullSequence(),++this.rowsNull);const n=this.splitter(e);for(let t=0;t<this.Length;t++){const e=this.positions[t].freq,i=n[this.startPosition+t]||"-";i in e||(e[i]=new p),e[i].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==u.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const n=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-n*Math.log2(n)}}}this._removeEmptyPositions();const s=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const n=this.positions[e].freq,r=this.positions[e].rowCount,a=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==a&&i.shell.error("WebLogo: alphabet is undefined.");const l=Math.log2(a),h=this.positionHeight==u.ES.Entropy?s*(l-this.positions[e].sumForHeightCalc)/l:s;let c=this.axisHeight*t+(s-h-1);const d=Object.entries(n).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of d){const n=t[1],i=h*n.count/r;n.bounds=new o.Rect(e*this.positionWidthWithMargin,c,this._positionWidth,i),c+=i}}}render(t=!0){var e;if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const n=this.canvas.getContext("2d");if(!n)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const i=window.devicePixelRatio;t&&this._calculate(i),n.resetTransform(),n.fillStyle=o.Color.toHtml(this.backgroundColor),n.fillRect(0,0,this.canvas.width,this.canvas.height),n.textBaseline=this.textBaseline;const s=this.countOfRenderPositions+1,r=this.visibleSlider?Math.floor(this.slider.min):0,a=Math.min(this.Length,r+s),l=10*i;n.resetTransform(),n.fillStyle="black",n.textAlign="center",n.font=`${l.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const h=Math.max(...this.positions.map((t=>n.measureText(t.name).width))),u=h<this._positionWidth-2?1:(this._positionWidth-2)/h;for(let t=this.firstVisibleIndex;t<a;t++){const e=this.positions[t];n.resetTransform(),n.setTransform(u,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*r,0),n.fillText(e.name,0,0)}for(let t=this.firstVisibleIndex;t<a;t++)for(const[i,s]of Object.entries(this.positions[t].freq))if("-"!==i){const t=(0,c.GU)(i,5),o=s.bounds,r=o.left-this.positionWidthWithMargin*this.firstVisibleIndex;n.resetTransform(),n.strokeStyle="lightgray",n.lineWidth=1,n.rect(r,o.top,o.width,o.height),n.fillStyle=null!==(e=this.cp.get(i))&&void 0!==e?e:this.cp.get("other"),n.textAlign="left",n.font="16px Roboto, Roboto Local, sans-serif";const a=n.measureText(t);n.setTransform(o.width/a.width,0,0,o.height/12.2,r,o.top),n.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,n=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,n*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${n}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let s=0;switch(this.verticalAlignment){case"top":s=0;break;case"middle":s=Math.max(0,(this.root.clientHeight-n)/2);break;case"bottom":s=Math.max(0,this.root.clientHeight-n-t)}let o=0;switch(this.horizontalAlignment){case"left":o=0;break;case"center":o=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":o=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${s}px`,"important"),this.host.style.setProperty("margin-left",`${o}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${s+i}px`,"important"),this.root.clientHeight<=n?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){var t,e;return null!==(e=null===(t=this.unitsHandler)||void 0===t?void 0:t.getAlphabetSize())&&void 0!==e?e:0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){console.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,n=window.devicePixelRatio,i=this.canvas.getCursorPosition(e,n),[o,r]=this.getMonomer(i);if(this.dataFrame&&this.seqCol&&this.splitter&&r){const t=this.positions[o],n=function(t,e,n,i,s,o){return a().count(0).take(t.rowCount).filter((t=>n.get(t))).map((t=>{const n=e.get(t),s=n?i(n):[],r=o.pos;return r<s.length?s[r]:null})).toArray().filter((t=>t==s)).reduce(((t,e)=>t+1),0)}(this.dataFrame,this.seqCol,this.filter,this.splitter,r,t),i=s.div([s.div(`${r}`),s.div(`${n} rows`)]);s.tooltip.show(i,e.x+16,e.y+16)}else s.tooltip.hide()}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,s]=this.getMonomer(this.canvas.getCursorPosition(e,n));if(this.dataFrame&&this.seqCol&&this.splitter&&s){const t=this.positions[i],e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,n,i,s,o,r){if(!n.getSelectedIndexes().includes(i))return!1;const a=e.get(i),l=a?s(a)[r.pos]:null;return l===o||""===l&&"-"===o}(this.dataFrame,this.seqCol,this.filter,e,this.splitter,s,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const e=t.deltaY/100*Math.max(Math.floor(this.countOfRenderPositions/2),1);this.slider.scrollBy(this.slider.min+e)}catch(t){const e=d(t);console.error("Bio: WebLogoViewer.canvasOnWheel() error:\n"+e)}}}y.residuesSet="nucleotides",y.viewerCount=-1},4413:(t,e,n)=>{"use strict";n.d(e,{ST:()=>m});var i=n(3870),s=n(976),o=n(4469),r=n(6414),a=n.n(r),l=n(7983),h=n(701),c=n(4293),u=n(1061);const d=rxjs.operators;var f=function(t,e,n,i){return new(n||(n=Promise))((function(s,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class m extends s.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return 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g{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}substrucrureSearch(t){return f(this,void 0,void 0,(function*(){return yield(0,l.pf)(this.substructure,t,this.colSeparator)}))}}class y extends p{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}init(){return f(this,void 0,void 0,(function*(){this.helmEditor=yield o.functions.call("HELM:helmWebEditor"),yield 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+var bio;(()=>{var t={8867:(t,e,n)=>{"use strict";n.d(e,{OW:()=>i});class i extends Float32Array{}},7997:(t,e,n)=>{"use strict";function i(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function r(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}n.d(e,{$G:()=>s,MA:()=>r,hu:()=>i}),n(8867)},2012:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(9976);class s extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,s)),this.lesk}static get GrokGroups(){return void 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this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.setTag(i.TAGS.UNITS,"fasta"),s.C.getOrCreate(e),[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},1821:(t,e,n)=>{"use strict";n.d(e,{BM:()=>s,XS:()=>o});var i=n(6286);const s=/\[(\w+)\]|(\w)|(-)/g,r=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},o=[new i.L("PT",r.fasta.peptide,.5),new i.L("DNA",r.fasta.dna,.55),new i.L("RNA",r.fasta.rna,.55)]},8447:(t,e,n)=>{"use strict";n.d(e,{GU:()=>i.GU,dQ:()=>i.dQ,kB:()=>i.kB,py:()=>i.py,up:()=>i.up,vU:()=>i.vU});var i=n(585)},6286:(t,e,n)=>{"use strict";n.d(e,{L:()=>i,d:()=>s});class i{constructor(t,e,n){this.name=t,this.alphabet=e,this.cutoff=n}}class s extends i{constructor(t,e,n){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=n}}},585:(t,e,n)=>{"use strict";n.d(e,{Ar:()=>p,GU:()=>S,Mj:()=>v,dQ:()=>T,kB:()=>f,py:()=>x,up:()=>E,vU:()=>w,w4:()=>M});var i=n(976),s=n(6414),r=n.n(s),o=n(6286),a=n(1821),l=n(499),h=n(8867),c=n(7997),u=n(2012),m=n(6137),d=n(7331);function f(t){return r()(t.toString().matchAll(a.BM)).map((t=>{const e=t[0];return"-"===e?"":e.length>1?t[1]:e})).toArray()}function p(t,e=undefined){return n=>n.split(t,e)}const g=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,y=/\[([^\[\]]+)]/g;function b(t){g.lastIndex=0;const e=g.exec(t.toString()),n=e?e[2]:null;return(n?n.split("."):[]).map((t=>{y.lastIndex=0;const e=y.exec(t);return e&&e.length>=2?e[1]:t}))}function w(t,e,n=undefined){if(t.toLowerCase().startsWith("fasta"))return f;if(t.toLowerCase().startsWith("separator"))return p(e,n);if(t.toLowerCase().startsWith("helm"))return b;throw new Error(`Unexpected units ${t} .`)}function v(t){if(t.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`Get splitter for semType "${i.SEMTYPE.MACROMOLECULE}" only.`);return w(t.getTag(i.TAGS.UNITS),t.getTag("separator"))}const C=/(\w+)/g;function S(t,e){var n,i;const s=t.match(C),r=t.length>e||(null!==(n=null==s?void 0:s.length)&&void 0!==n?n:0)>1,o=null!==(i=null==s?void 0:s[0])&&void 0!==i?i:" ";return r?o.substring(0,e)+"…":o}function M(t,e,n="-"){const i=e.map((e=>{const i=function(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const s=[],r=[];for(const n of i)s.push(n in t?t[n]:0),r.push(e.has(n)?1:0);const o=new h.OW(s),a=new h.OW(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,n);return new o.d(e,t,i)}));let s;const r=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return s=r>0?i.find((t=>t.similarity===r)).name:"UN",s}function T(t,e=5){let n;if(t.semType==i.SEMTYPE.MACROMOLECULE)n=l.C.getOrCreate(t).alphabet;else{const i=function(t,e,n){return t.categories,function(t,e){const n={};let i=!0,s=null;for(const r of t)if(null==s?s=r.length:r.length!==s&&(i=!1),r.length>=e)for(const t of r)t in n||(n[t]=0),n[t]+=1;return{freq:n,sameLength:i}}(r()(t.getRawData()).map((e=>n(t.categories[e]))),e)}(t,e,f);n=M(i.freq,a.XS)}return x(n)}function x(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function E(t){var e;const n=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=null!==(e=n.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")})))&&void 0!==e?e:null;return!s&&n.length>0&&(s=n[0]),s}},7767:(t,e,n)=>{"use strict";n.d(e,{L:()=>o});var i=n(976),s=n(499),r=n(585);class o extends s.C{get splitter(){return null===this._splitter&&(this._splitter=(0,r.Mj)(this.column)),this._splitter}toFasta(t){return"fasta"===t}toSeparator(t){return"separator"===t}toHelm(t){return"helm"===t}convertFastaToSeparator(t,e=null){null===e&&(e=this.defaultGapSymbol);const n=this.getNewColumn("separator",t);return n.init((n=>{const i=this.column.get(n),r=this.splitter(i);for(let t=0;t<r.length;t++)r[t]===e&&(r[t]=s.C._defaultGapSymbolsDict.SEPARATOR);return r.join(t)})),n.setTag(i.TAGS.UNITS,"separator"),n}getHelmWrappers(){const t=this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":this.isPeptide()?"PEPTIDE1{":"Unknown";if("Unknown"===t)throw new Error("Neither peptide, nor nucleotide");return[t,this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}convertToHelmHelper(t,e,n,i,r,o){return`${n}${this.splitter(t).map((t=>t&&t!==e?`${i}${t}${r}`:s.C._defaultGapSymbolsDict.HELM)).join(".")}${o}`}convertStringToHelm(t,e=null){null===e&&(e=this.defaultGapSymbol);const[n,i,s,r]=this.getHelmWrappers();return this.convertToHelmHelper(t,e,n,i,s,r)}convertToHelm(t=null){null===t&&(t=this.defaultGapSymbol);const[e,n,s,r]=this.getHelmWrappers(),o=this.getNewColumn("helm");return o.init((i=>{const o=this.column.get(i);return this.convertToHelmHelper(o,t,e,n,s,r)})),o.setTag(i.TAGS.UNITS,"helm"),o}convertSeparatorToFasta(t=null){null===t&&(t=s.C._defaultGapSymbolsDict.FASTA);const e=this.getNewColumn("fasta");return e.init((e=>{const n=this.column.get(e),i=this.splitter(n),s=[];for(let e=0;e<i.length;e++){const n=i[e];if(0===n.length)s.push(t);else if(n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join("")})),e.setTag(i.TAGS.UNITS,"fasta"),e}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?s.C._defaultGapSymbolsDict.FASTA:s.C._defaultGapSymbolsDict.SEPARATOR),n||(n=this.toFasta(e)?"":this.separator);const r=/(R\(|D\(|\)|P)/g,o=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let n=a[t];if(o&&(n=n.replace(r,"")),n===s.C._defaultGapSymbolsDict.HELM)l.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";l.push(t)}else l.push(n)}return l.join(n)}convertHelm(t,e,n){const i=this.getNewColumn(t,e);i.init((i=>{const s=this.column.get(i);return this.convertHelmToFastaSeparator(s,t,e,n)})),(0,r.Mj)(i);const s=this.stats.sameLength?"SEQ.MSA":"SEQ";return i.setTag("aligned",s),i}convertHelmToSeparator(){return this.getNewColumn("separator")}convert(t,e=null){if(this.notation===t)throw new Error("tgt notation is invalid");if(this.toSeparator(t)&&null===e)throw new Error("tgt separator is not specified");if(this.isFasta()&&this.toSeparator(t)&&null!==e)return this.convertFastaToSeparator(e);if((this.isFasta()||this.isSeparator())&&this.toHelm(t))return this.convertToHelm();if(this.isSeparator()&&this.toFasta(t))return this.convertSeparatorToFasta();if(this.isHelm()&&this.toFasta(t))return this.convertHelm(t);if(this.isHelm()&&this.toSeparator(t))return this.convertHelm(t,e);throw new Error(`Not supported conversion from source notation '${this.notation}' to target notation '${t}'.`)}constructor(t){super(t),this._splitter=null}}},499:(t,e,n)=>{"use strict";n.d(e,{C:()=>h});var i=n(976),s=n(1821),r=n(585),o=n(489),a=n(7228);const l=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}};class h{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||"fasta"!==t.column.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'fasta' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,"fasta"),h.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||"separator"!==t.column.getTag(i.TAGS.UNITS))throw new Error(`The column of notation 'separator' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error("The column of notation 'separator' must have the separator tag.");t.column.setTag(i.TAGS.UNITS,"separator"),t.column.setTag("separator",e),h.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation 'helm' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,"helm"),h.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),n=t.stats;if(Object.keys(n.freq).some((t=>t.length>1)),["fasta","separator"].includes(e)){if(0===Object.keys(n.freq).length)throw new Error("Alphabet is empty");const e=n.sameLength?"SEQ.MSA":"SEQ";t.column.setTag("aligned",e);const i=(0,r.w4)(n.freq,s.XS);if(t.column.setTag("alphabet",i),"UN"===i){const e=Object.keys(n.freq).length,i=Object.keys(n.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get units(){return this._units}get column(){return this._column}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){var t;const e=null!==(t=this.column.getTag("separator"))&&void 0!==t?t:void 0;if("separator"===this.notation&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if("helm"==this.notation||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return"helm"===this.notation||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const n=this._column.getRawData(),i=this._column.categories;for(let s=0;s<e;s++){const e=i[n[s]];this._splitted[s]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,n=null;for(const i of this.splitted){null==n?n=i.length:i.length!==n&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}isFasta(){return"fasta"===this.notation}isSeparator(){return"separator"===this.notation}isHelm(){return"helm"===this.notation}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}getNotation(){if(this.units.toLowerCase().startsWith("fasta"))return"fasta";if(this.units.toLowerCase().startsWith("separator"))return"separator";if(this.units.toLowerCase().startsWith("helm"))return"helm";throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getNewColumn(t,e){const n=this.column,s=n.length,r=t.toLowerCase()+"("+n.name+")",o=n.dataFrame.columns.getUnusedName(r),a=i.Column.fromList("string",o,new Array(s).fill(""));if(a.semType=i.SEMTYPE.MACROMOLECULE,a.setTag(i.TAGS.UNITS,t),"separator"===t){if(!e)throw new Error("Notation 'separator' requires separator value.");a.setTag("separator",e)}a.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const l=n.getTag("aligned");l&&a.setTag("aligned",l);const h=n.getTag("alphabet");h&&a.setTag("alphabet",h);let c=n.getTag(".alphabetSize");c&&a.setTag(".alphabetSize",c);const u=n.getTag(".alphabetIsMultichar");return void 0!==u&&a.setTag(".alphabetIsMultichar",u),"helm"==t&&(c=this.getAlphabetSize().toString(),a.setTag(".alphabetSize",c)),a}static getNewColumn(t){const e=h.getOrCreate(t),n=e.notation;return e.getNewColumn(n)}static unitsStringIsValid(t){return t=t.toLowerCase(),["fasta","separator","helm"].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!h.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const s=i.Column.fromList("string",e,new Array(t).fill(""));return s.semType=i.SEMTYPE.MACROMOLECULE,s.setTag(i.TAGS.UNITS,n),s}getSplitter(){return(0,r.Mj)(this._column)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return o.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return o.U.LEVENSHTEIN;case"PT":return o.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return o.o[this.getDistanceFunctionName()]()}checkHelmCompatibility(){return t=this,e=void 0,i=function*(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(yield(0,a.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),n=(0,r.Ar)(this.separator);for(const t of this.column.categories){const i=n(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0},new((n=void 0)||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}));var t,e,n,i}constructor(t){this._splitted=null,this._stats=null,this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?h._defaultGapSymbolsDict.FASTA:this.isHelm()?h._defaultGapSymbolsDict.HELM:h._defaultGapSymbolsDict.SEPARATOR,!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())h.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");h.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);h.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return l.uhTemp in t.temp||(t.temp[l.uhTemp]=new h(t)),t.temp[l.uhTemp]}}h._defaultGapSymbolsDict={HELM:"*",SEPARATOR:"",FASTA:"-"}},9298:(t,e,n)=>{"use strict";var i,s,r,o,a;n.d(e,{CI:()=>h,Ct:()=>a,DX:()=>c,ES:()=>i,dE:()=>o,iD:()=>r,vS:()=>l,vw:()=>s}),function(t){t.Entropy="Entropy",t.full="100%"}(i||(i={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(s||(s={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(r||(r={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(o||(o={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(a||(a={}));const l=new 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Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[e]&&(t[e]=this.get(e,n));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t[n]&&(t[n]=this.get(e,n));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.get(e,n)<t&&(t=this.get(e,n));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){x(this);let t=this.get(0,0),e=[0,0];for(let n=0;n<this.rows;n++)for(let i=0;i<this.columns;i++)this.get(n,i)<t&&(t=this.get(n,i),e[0]=n,e[1]=i);return e}maxRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)>e&&(e=this.get(t,n));return e}maxRowIndex(t){b(this,t),x(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),n[1]=i);return n}minRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n));return e}minRowIndex(t){b(this,t),x(this);let e=this.get(t,0),n=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),n[1]=i);return n}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t));return e}maxColumnIndex(t){w(this,t),x(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),n[0]=i);return n}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t));return e}minColumnIndex(t){w(this,t),x(this);let e=this.get(0,t),n=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),n[0]=i);return n}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let n=0;n<t;n++)e.push(this.get(n,n));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let n=0;n<this.columns;n++)e+=this.get(t,n)*this.get(t,n);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t+=this.get(e,n),this.set(e,n,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}mmul(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.columns,s=new A(e,i),r=new Float64Array(n);for(let o=0;o<i;o++){for(let e=0;e<n;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let i=0;i<n;i++)e+=this.get(t,i)*r[i];s.set(t,o,e)}}return s}strassen2x2(t){t=A.checkMatrix(t);let e=new A(2,2);const n=this.get(0,0),i=t.get(0,0),s=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(n+l)*(i+h),u=(o+l)*i,m=n*(r-h),d=l*(a-i),f=(n+s)*h,p=c+d-f+(s-l)*(a+h),g=m+f,y=u+d,b=c-u+m+(o-n)*(i+r);return e.set(0,0,p),e.set(0,1,g),e.set(1,0,y),e.set(1,1,b),e}strassen3x3(t){t=A.checkMatrix(t);let e=new A(3,3);const n=this.get(0,0),i=this.get(0,1),s=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),f=t.get(1,0),p=t.get(1,1),g=t.get(1,2),y=t.get(2,0),b=t.get(2,1),w=t.get(2,2),v=(n-r)*(-m+p),C=(-n+r+o)*(u-m+p),S=(r+o)*(-u+m),M=n*u,T=(-n+l+h)*(u-d+g),x=(-n+l)*(d-g),E=(l+h)*(-u+d),N=(-s+h+c)*(p+y-b),I=(s-c)*(p-b),L=s*y,k=(h+c)*(-y+b),_=(-s+o+a)*(g+y-w),R=(s-a)*(g-w),O=(o+a)*(-y+w),G=M+L+i*f,P=(n+i+s-r-o-h-c)*p+C+S+M+N+L+k,F=M+T+E+(n+i+s-o-a-l-h)*g+L+_+O,W=v+o*(-u+m+f-p-g-y+w)+C+M+L+_+R,V=v+C+S+M+a*b,H=L+_+R+O+r*d,Z=M+T+x+h*(-u+d+f-p-g-y+b)+N+I+L,U=N+I+L+k+l*m,D=M+T+x+E+c*w;return e.set(0,0,G),e.set(0,1,P),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,Z),e.set(2,1,U),e.set(2,2,D),e}mmulStrassen(t){t=A.checkMatrix(t);let e=this.clone(),n=e.rows,i=e.columns,s=t.rows,r=t.columns;function o(t,e,n){let i=t.rows,s=t.columns;if(i===e&&s===n)return t;{let i=E.zeros(e,n);return i=i.setSubMatrix(t,0,0),i}}i!==s&&console.warn(`Multiplying ${n} x ${i} and ${s} x ${r} matrix: dimensions do not match.`);let a=Math.max(n,s),l=Math.max(i,r);return e=o(e,a,l),function t(e,n,i,s){if(i<=512||s<=512)return e.mmul(n);i%2==1&&s%2==1?(e=o(e,i+1,s+1),n=o(n,i+1,s+1)):i%2==1?(e=o(e,i+1,s),n=o(n,i+1,s)):s%2==1&&(e=o(e,i,s+1),n=o(n,i,s+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=n.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=n.subMatrix(0,r-1,a,n.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=n.subMatrix(r,n.rows-1,0,a-1),f=e.subMatrix(r,e.rows-1,a,e.columns-1),p=n.subMatrix(r,n.rows-1,a,n.columns-1),g=t(E.add(l,f),E.add(h,p),r,a),y=t(E.add(m,f),h,r,a),b=t(l,E.sub(u,p),r,a),w=t(f,E.sub(d,h),r,a),v=t(E.add(l,c),p,r,a),C=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,f),E.add(d,p),r,a),M=E.add(g,w);M.sub(v),M.add(S);let T=E.add(b,v),x=E.add(y,w),N=E.sub(g,y);N.add(b),N.add(C);let A=E.zeros(2*M.rows,2*M.columns);return A=A.setSubMatrix(M,0,0),A=A.setSubMatrix(T,M.rows,0),A=A.setSubMatrix(x,0,M.columns),A=A.setSubMatrix(N,M.rows,M.columns),A.subMatrix(0,i-1,0,s-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.rows;t++){const s=this.getRow(t);s.length>0&&m(s,{min:e,max:n,output:s}),i.setRow(t,s)}return i}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:n=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(n))throw new TypeError("max must be a number");if(e>=n)throw new RangeError("min must be smaller than max");let i=new A(this.rows,this.columns);for(let t=0;t<this.columns;t++){const s=this.getColumn(t);s.length&&m(s,{min:e,max:n,output:s}),i.setColumn(t,s)}return i}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let n=0;n<t;n++){let t=this.get(e,n),i=this.get(e,this.columns-1-n);this.set(e,n,i),this.set(e,this.columns-1-n,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let n=0;n<t;n++){let t=this.get(n,e),i=this.get(this.rows-1-n,e);this.set(n,e,i),this.set(this.rows-1-n,e,t)}return this}kroneckerProduct(t){t=A.checkMatrix(t);let e=this.rows,n=this.columns,i=t.rows,s=t.columns,r=new A(e*i,n*s);for(let o=0;o<e;o++)for(let e=0;e<n;e++)for(let n=0;n<i;n++)for(let a=0;a<s;a++)r.set(i*o+n,s*e+a,this.get(o,e)*t.get(n,a));return r}kroneckerSum(t){if(t=A.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,n=t.rows,i=this.kroneckerProduct(A.eye(n,n)),s=A.eye(e,e).kroneckerProduct(t);return i.add(s)}transpose(){let t=new A(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(n,e,this.get(e,n));return t}sortRows(t=N){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=N){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,n,i){S(this,t,e,n,i);let s=new A(e-t+1,i-n+1);for(let r=t;r<=e;r++)for(let e=n;e<=i;e++)s.set(r-t,e-n,this.get(r,e));return s}subMatrixRow(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.columns-1),e>n||e<0||e>=this.columns||n<0||n>=this.columns)throw new RangeError("Argument out of range");let i=new A(t.length,n-e+1);for(let s=0;s<t.length;s++)for(let r=e;r<=n;r++){if(t[s]<0||t[s]>=this.rows)throw new RangeError(`Row index out of range: ${t[s]}`);i.set(s,r-e,this.get(t[s],r))}return i}subMatrixColumn(t,e,n){if(void 0===e&&(e=0),void 0===n&&(n=this.rows-1),e>n||e<0||e>=this.rows||n<0||n>=this.rows)throw new RangeError("Argument out of range");let i=new A(n-e+1,t.length);for(let s=0;s<t.length;s++)for(let r=e;r<=n;r++){if(t[s]<0||t[s]>=this.columns)throw new RangeError(`Column index out of range: ${t[s]}`);i.set(r-e,s,this.get(r,t[s]))}return i}setSubMatrix(t,e,n){if((t=A.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,n,n+t.columns-1);for(let i=0;i<t.rows;i++)for(let s=0;s<t.columns;s++)this.set(e+i,n+s,t.get(i,s));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let n=0;n<e.length;n++)if(e[n]<0||e[n]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let n=new A(t.length,e.length);for(let i=0;i<t.length;i++){let s=t[i];for(let t=0;t<e.length;t++){let r=e[t];n.set(i,t,this.get(s,r))}}return n}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let n=0;n<t;n++)e+=this.get(n,n);return e}clone(){let t=new A(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)t.set(e,n,this.get(e,n));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]+=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]+=t.get(n,i);return e}(this);case void 0:return function(t){let e=0;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e+=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[n]*=t.get(n,i);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let n=0;n<t.rows;++n)for(let i=0;i<t.columns;++i)e[i]*=t.get(n,i);return e}(this);case void 0:return function(t){let e=1;for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)e*=t.get(n,i);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:n=!0,mean:i=this.mean(t)}=e;if("boolean"!=typeof n)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<s;e++)l=t.get(o,e)-n[o],i+=l,a+=l*l;e?r.push((a-i*i/s)/(s-1)):r.push((a-i*i/s)/s)}return r}(this,n,i);case"column":if(!a(i))throw new TypeError("mean must be an array");return function(t,e,n){const i=t.rows,s=t.columns,r=[];for(let o=0;o<s;o++){let s=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(e,o)-n[o],s+=l,a+=l*l;e?r.push((a-s*s/i)/(i-1)):r.push((a-s*s/i)/i)}return r}(this,n,i);case void 0:if("number"!=typeof i)throw new TypeError("mean must be a number");return function(t,e,n){const i=t.rows,s=t.columns,r=i*s;let o=0,a=0,l=0;for(let e=0;e<i;e++)for(let i=0;i<s;i++)l=t.get(e,i)-n,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,n,i);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const n=this.variance(t,e);if(void 0===t)return Math.sqrt(n);for(let t=0;t<n.length;t++)n[t]=Math.sqrt(n[t]);return n}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:n=this.mean(t)}=e;switch(t){case"row":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[n])}(this,n),this;case"column":if(!a(n))throw new TypeError("center must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e[i])}(this,n),this;case void 0:if("number"!=typeof n)throw new TypeError("center must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)-e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let n=e.scale;switch(t){case"row":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.rows;n++){let i=0;for(let e=0;e<t.columns;e++)i+=Math.pow(t.get(n,e),2)/(t.columns-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[n])}(this,n),this;case"column":if(void 0===n)n=function(t){const e=[];for(let n=0;n<t.columns;n++){let i=0;for(let e=0;e<t.rows;e++)i+=Math.pow(t.get(e,n),2)/(t.rows-1);e.push(Math.sqrt(i))}return e}(this);else if(!a(n))throw new TypeError("scale must be an array");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e[i])}(this,n),this;case void 0:if(void 0===n)n=function(t){const e=t.size-1;let n=0;for(let i=0;i<t.columns;i++)for(let s=0;s<t.rows;s++)n+=Math.pow(t.get(s,i),2)/e;return Math.sqrt(n)}(this);else if("number"!=typeof n)throw new TypeError("scale must be a number");return function(t,e){for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)t.set(n,i,t.get(n,i)/e)}(this,n),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return p(this,t)}}function N(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return p(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class A extends E{constructor(t,e){if(super(),A.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let n=0;n<t;n++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const n=t;if("number"!=typeof(e=(t=n.length)?n[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let i=0;i<t;i++){if(n[i].length!==e)throw new RangeError("Inconsistent array dimensions");if(!n[i].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(n[i]))}}}this.rows=t,this.columns=e}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}removeRow(t){return b(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),b(this,t,!0),e=Float64Array.from(v(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const n=new Float64Array(this.columns-1);for(let i=0;i<t;i++)n[i]=this.data[e][i];for(let i=t+1;i<this.columns;i++)n[i-1]=this.data[e][i];this.data[e]=n}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=C(this,e);for(let n=0;n<this.rows;n++){const i=new Float64Array(this.columns+1);let s=0;for(;s<t;s++)i[s]=this.data[n][s];for(i[s++]=e[n];s<this.columns+1;s++)i[s]=this.data[n][s-1];this.data[n]=i}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)+t.get(e,n));return this},t.add=function(t,n){return new e(t).add(n)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)-t.get(e,n));return this},t.sub=function(t,n){return new e(t).sub(n)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)*t.get(e,n));return this},t.mul=function(t,n){return new e(t).mul(n)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)/t.get(e,n));return this},t.div=function(t,n){return new e(t).div(n)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)%t.get(e,n));return this},t.mod=function(t,n){return new e(t).mod(n)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)&t.get(e,n));return this},t.and=function(t,n){return new e(t).and(n)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)|t.get(e,n));return this},t.or=function(t,n){return new e(t).or(n)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)^t.get(e,n));return this},t.xor=function(t,n){return new e(t).xor(n)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)<<t.get(e,n));return this},t.leftShift=function(t,n){return new e(t).leftShift(n)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>t.get(e,n));return this},t.signPropagatingRightShift=function(t,n){return new e(t).signPropagatingRightShift(n)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,this.get(e,n)>>>t.get(e,n));return this},t.rightShift=function(t,n){return new e(t).rightShift(n)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,n){return new e(t).pow(n)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let n=0;n<this.columns;n++)this.set(e,n,Math.pow(this.get(e,n),t.get(e,n)));return this}}(E,A);class I extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,n){return this.data[t][e]=n,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,n,i,s,r,o,a,l,h,c=(t=I.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),f=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),n=0;n<m;n++){for(e=0;e<u;e++)l[e]=c.get(e,n);for(e=0;e<u;e++){for(h=Math.min(e,n),r=0,i=0;i<h;i++)r+=c.get(e,i)*l[i];l[e]-=r,c.set(e,n,l[e])}for(s=n,e=n+1;e<u;e++)Math.abs(l[e])>Math.abs(l[s])&&(s=e);if(s!==n){for(i=0;i<m;i++)o=c.get(s,i),c.set(s,i,c.get(n,i)),c.set(n,i,o);a=d[s],d[s]=d[n],d[n]=a,f=-f}if(n<u&&0!==c.get(n,n))for(e=n+1;e<u;e++)c.set(e,n,c.get(e,n)/c.get(n,n))}this.LU=c,this.pivotVector=d,this.pivotSign=f}isSingular(){let t=this.LU,e=t.columns;for(let n=0;n<e;n++)if(0===t.get(n,n))return!0;return!1}solve(t){t=A.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let n,i,s,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(s=0;s<a;s++)for(n=s+1;n<a;n++)for(i=0;i<r;i++)o.set(n,i,o.get(n,i)-o.get(s,i)*e.get(n,s));for(s=a-1;s>=0;s--){for(i=0;i<r;i++)o.set(s,i,o.get(s,i)/e.get(s,s));for(n=0;n<s;n++)for(i=0;i<r;i++)o.set(n,i,o.get(n,i)-o.get(s,i)*e.get(n,s))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,n=t.columns;for(let i=0;i<n;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s>e?i.set(s,e,t.get(s,e)):s===e?i.set(s,e,1):i.set(s,e,0);return i}get upperTriangularMatrix(){let t=this.LU,e=t.rows,n=t.columns,i=new A(e,n);for(let s=0;s<e;s++)for(let e=0;e<n;e++)s<=e?i.set(s,e,t.get(s,e)):i.set(s,e,0);return i}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function k(t,e){let n=0;return Math.abs(t)>Math.abs(e)?(n=e/t,Math.abs(t)*Math.sqrt(1+n*n)):0!==e?(n=t/e,Math.abs(e)*Math.sqrt(1+n*n)):0}class _{constructor(t){let e,n,i,s,r=(t=I.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(i=0;i<a;i++){let t=0;for(e=i;e<o;e++)t=k(t,r.get(e,i));if(0!==t){for(r.get(i,i)<0&&(t=-t),e=i;e<o;e++)r.set(e,i,r.get(e,i)/t);for(r.set(i,i,r.get(i,i)+1),n=i+1;n<a;n++){for(s=0,e=i;e<o;e++)s+=r.get(e,i)*r.get(e,n);for(s=-s/r.get(i,i),e=i;e<o;e++)r.set(e,n,r.get(e,n)+s*r.get(e,i))}}l[i]=-t}this.QR=r,this.Rdiag=l}solve(t){t=A.checkMatrix(t);let e=this.QR,n=e.rows;if(t.rows!==n)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let i,s,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(s=0;s<a;s++){for(o=0,i=r;i<n;i++)o+=e.get(i,r)*l.get(i,s);for(o=-o/e.get(r,r),i=r;i<n;i++)l.set(i,s,l.get(i,s)+o*e.get(i,r))}for(r=h-1;r>=0;r--){for(s=0;s<a;s++)l.set(r,s,l.get(r,s)/this.Rdiag[r]);for(i=0;i<r;i++)for(s=0;s<a;s++)l.set(i,s,l.get(i,s)-l.get(r,s)*e.get(i,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,n=this.QR,i=n.columns,s=new A(i,i);for(t=0;t<i;t++)for(e=0;e<i;e++)t<e?s.set(t,e,n.get(t,e)):t===e?s.set(t,e,this.Rdiag[t]):s.set(t,e,0);return s}get orthogonalMatrix(){let t,e,n,i,s=this.QR,r=s.rows,o=s.columns,a=new A(r,o);for(n=o-1;n>=0;n--){for(t=0;t<r;t++)a.set(t,n,0);for(a.set(n,n,1),e=n;e<o;e++)if(0!==s.get(n,n)){for(i=0,t=n;t<r;t++)i+=s.get(t,n)*a.get(t,e);for(i=-i/s.get(n,n),t=n;t<r;t++)a.set(t,e,a.get(t,e)+i*s.get(t,n))}}return a}}class R{constructor(t,e={}){if((t=I.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let n=t.rows,i=t.columns;const{computeLeftSingularVectors:s=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(s),h=Boolean(r),c=!1;if(n<i)if(o){a=t.transpose(),n=a.rows,i=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(n,i),m=Math.min(n+1,i),d=new Float64Array(m),f=new A(n,u),p=new A(i,i),g=new Float64Array(i),y=new Float64Array(n),b=new Float64Array(m);for(let t=0;t<m;t++)b[t]=t;let w=Math.min(n-1,i),v=Math.max(0,Math.min(i-2,n)),C=Math.max(w,v);for(let t=0;t<C;t++){if(t<w){d[t]=0;for(let e=t;e<n;e++)d[t]=k(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<n;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<i;e++){if(t<w&&0!==d[t]){let i=0;for(let s=t;s<n;s++)i+=a.get(s,t)*a.get(s,e);i=-i/a.get(t,t);for(let s=t;s<n;s++)a.set(s,e,a.get(s,e)+i*a.get(s,t))}g[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<n;e++)f.set(e,t,a.get(e,t));if(t<v){g[t]=0;for(let e=t+1;e<i;e++)g[t]=k(g[t],g[e]);if(0!==g[t]){g[t+1]<0&&(g[t]=0-g[t]);for(let e=t+1;e<i;e++)g[e]/=g[t];g[t+1]+=1}if(g[t]=-g[t],t+1<n&&0!==g[t]){for(let e=t+1;e<n;e++)y[e]=0;for(let e=t+1;e<n;e++)for(let n=t+1;n<i;n++)y[e]+=g[n]*a.get(e,n);for(let e=t+1;e<i;e++){let i=-g[e]/g[t+1];for(let s=t+1;s<n;s++)a.set(s,e,a.get(s,e)+i*y[s])}}if(h)for(let e=t+1;e<i;e++)p.set(e,t,g[e])}}let S=Math.min(i,n+1);if(w<i&&(d[w]=a.get(w,w)),n<S&&(d[S-1]=0),v+1<S&&(g[v]=a.get(v,S-1)),g[S-1]=0,l){for(let t=w;t<u;t++){for(let e=0;e<n;e++)f.set(e,t,0);f.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let i=0;for(let s=t;s<n;s++)i+=f.get(s,t)*f.get(s,e);i=-i/f.get(t,t);for(let s=t;s<n;s++)f.set(s,e,f.get(s,e)+i*f.get(s,t))}for(let e=t;e<n;e++)f.set(e,t,-f.get(e,t));f.set(t,t,1+f.get(t,t));for(let e=0;e<t-1;e++)f.set(e,t,0)}else{for(let e=0;e<n;e++)f.set(e,t,0);f.set(t,t,1)}}if(h)for(let t=i-1;t>=0;t--){if(t<v&&0!==g[t])for(let e=t+1;e<i;e++){let n=0;for(let s=t+1;s<i;s++)n+=p.get(s,t)*p.get(s,e);n=-n/p.get(t+1,t);for(let s=t+1;s<i;s++)p.set(s,e,p.get(s,e)+n*p.get(s,t))}for(let e=0;e<i;e++)p.set(e,t,0);p.set(t,t,1)}let M=S-1,T=0,x=Number.EPSILON;for(;S>0;){let t,e;for(t=S-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+x*Math.abs(d[t]+Math.abs(d[t+1]));if(Math.abs(g[t])<=e||Number.isNaN(g[t])){g[t]=0;break}}if(t===S-2)e=4;else{let n;for(n=S-1;n>=t&&n!==t;n--){let e=(n!==S?Math.abs(g[n]):0)+(n!==t+1?Math.abs(g[n-1]):0);if(Math.abs(d[n])<=x*e){d[n]=0;break}}n===t?e=3:n===S-1?e=1:(e=2,t=n)}switch(t++,e){case 1:{let e=g[S-2];g[S-2]=0;for(let n=S-2;n>=t;n--){let s=k(d[n],e),r=d[n]/s,o=e/s;if(d[n]=s,n!==t&&(e=-o*g[n-1],g[n-1]=r*g[n-1]),h)for(let t=0;t<i;t++)s=r*p.get(t,n)+o*p.get(t,S-1),p.set(t,S-1,-o*p.get(t,n)+r*p.get(t,S-1)),p.set(t,n,s)}break}case 2:{let e=g[t-1];g[t-1]=0;for(let i=t;i<S;i++){let s=k(d[i],e),r=d[i]/s,o=e/s;if(d[i]=s,e=-o*g[i],g[i]=r*g[i],l)for(let e=0;e<n;e++)s=r*f.get(e,i)+o*f.get(e,t-1),f.set(e,t-1,-o*f.get(e,i)+r*f.get(e,t-1)),f.set(e,i,s)}break}case 3:{const e=Math.max(Math.abs(d[S-1]),Math.abs(d[S-2]),Math.abs(g[S-2]),Math.abs(d[t]),Math.abs(g[t])),s=d[S-1]/e,r=d[S-2]/e,o=g[S-2]/e,a=d[t]/e,c=g[t]/e,u=((r+s)*(r-s)+o*o)/2,m=s*o*(s*o);let y=0;0===u&&0===m||(y=u<0?0-Math.sqrt(u*u+m):Math.sqrt(u*u+m),y=m/(u+y));let b=(a+s)*(a-s)+y,w=a*c;for(let e=t;e<S-1;e++){let s=k(b,w);0===s&&(s=Number.MIN_VALUE);let r=b/s,o=w/s;if(e!==t&&(g[e-1]=s),b=r*d[e]+o*g[e],g[e]=r*g[e]-o*d[e],w=o*d[e+1],d[e+1]=r*d[e+1],h)for(let t=0;t<i;t++)s=r*p.get(t,e)+o*p.get(t,e+1),p.set(t,e+1,-o*p.get(t,e)+r*p.get(t,e+1)),p.set(t,e,s);if(s=k(b,w),0===s&&(s=Number.MIN_VALUE),r=b/s,o=w/s,d[e]=s,b=r*g[e]+o*d[e+1],d[e+1]=-o*g[e]+r*d[e+1],w=o*g[e+1],g[e+1]=r*g[e+1],l&&e<n-1)for(let t=0;t<n;t++)s=r*f.get(t,e)+o*f.get(t,e+1),f.set(t,e+1,-o*f.get(t,e)+r*f.get(t,e+1)),f.set(t,e,s)}g[S-2]=b,T+=1;break}case 4:if(d[t]<=0&&(d[t]=d[t]<0?-d[t]:0,h))for(let e=0;e<=M;e++)p.set(e,t,-p.get(e,t));for(;t<M&&!(d[t]>=d[t+1]);){let e=d[t];if(d[t]=d[t+1],d[t+1]=e,h&&t<i-1)for(let n=0;n<i;n++)e=p.get(n,t+1),p.set(n,t+1,p.get(n,t)),p.set(n,t,e);if(l&&t<n-1)for(let i=0;i<n;i++)e=f.get(i,t+1),f.set(i,t+1,f.get(i,t)),f.set(i,t,e);t++}T=0,S--}}if(c){let t=p;p=f,f=t}this.m=n,this.n=i,this.s=d,this.U=f,this.V=p}solve(t){let e=t,n=this.threshold,i=this.s.length,s=A.zeros(i,i);for(let t=0;t<i;t++)Math.abs(this.s[t])<=n?s.set(t,t,0):s.set(t,t,1/this.s[t]);let r=this.U,o=this.rightSingularVectors,a=o.mmul(s),l=o.rows,h=r.rows,c=A.zeros(l,h);for(let t=0;t<l;t++)for(let e=0;e<h;e++){let n=0;for(let s=0;s<i;s++)n+=a.get(t,s)*r.get(e,s);c.set(t,e,n)}return c.mmul(e)}solveForDiagonal(t){return this.solve(A.diag(t))}inverse(){let t=this.V,e=this.threshold,n=t.rows,i=t.columns,s=new A(n,this.s.length);for(let r=0;r<n;r++)for(let n=0;n<i;n++)Math.abs(this.s[n])>e&&s.set(r,n,t.get(r,n)/this.s[n]);let r=this.U,o=r.rows,a=r.columns,l=new A(n,o);for(let t=0;t<n;t++)for(let e=0;e<o;e++){let n=0;for(let i=0;i<a;i++)n+=s.get(t,i)*r.get(e,i);l.set(t,e,n)}return l}get condition(){return this.s[0]/this.s[Math.min(this.m,this.n)-1]}get norm2(){return this.s[0]}get rank(){let t=Math.max(this.m,this.n)*this.s[0]*Number.EPSILON,e=0,n=this.s;for(let i=0,s=n.length;i<s;i++)n[i]>t&&e++;return e}get diagonal(){return Array.from(this.s)}get threshold(){return Number.EPSILON/2*Math.max(this.m,this.n)*this.s[0]}get leftSingularVectors(){return this.U}get rightSingularVectors(){return this.V}get diagonalMatrix(){return A.diag(this.s)}}function O(t,e,n,i,s){let r=n*i*i,o=A.eye(e.length,e.length,r);const a=s(e);let l=new Float64Array(t.x.length);for(let e=0;e<t.x.length;e++)l[e]=a(t.x[e]);let h=function(t,e,n,i,s){const r=n.length,o=t.x.length;let a=new Array(r);for(let l=0;l<r;l++){a[l]=new Array(o);let r=n.slice();r[l]+=i;let h=s(r);for(let n=0;n<o;n++)a[l][n]=e[n]-h(t.x[n])}return new A(a)}(t,l,e,i,s),c=function(t,e){const n=t.x.length;let i=new Array(n);for(let s=0;s<n;s++)i[s]=[t.y[s]-e[s]];return new A(i)}(t,l),u=function(t,e=!1){return t=I.checkMatrix(t),e?new R(t).inverse():function(t,e,n=!1){return t=I.checkMatrix(t),e=I.checkMatrix(e),n?new R(t).solve(e):t.isSquare()?new L(t).solve(e):new _(t).solve(e)}(t,A.eye(t.rows))}(o.add(h.mmul(h.transpose())));return(e=(e=new A([e])).sub(u.mmul(h).mmul(c).mul(i).transpose())).to1DArray()}function G(t,e,n={}){let{maxIterations:i=100,gradientDifference:o=.1,damping:a=0,errorTolerance:l=.01,minValues:h,maxValues:c,initialValues:u}=n;if(a<=0)throw new Error("The damping option must be a positive number");if(!t.x||!t.y)throw new Error("The data parameter must have x and y elements");if(!s(t.x)||t.x.length<2||!s(t.y)||t.y.length<2)throw new Error("The data parameter elements must be an array with more than 2 points");if(t.x.length!==t.y.length)throw new Error("The data parameter elements must have the same size");let m=u||new Array(e.length).fill(1),d=m.length;if(c=c||new Array(d).fill(Number.MAX_SAFE_INTEGER),h=h||new Array(d).fill(Number.MIN_SAFE_INTEGER),c.length!==h.length)throw new Error("minValues 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i=n(4469),s=n(3870),r=n(976),o=n(585);const a=o.GU;var l;!function(t){t.MSA="MSA",t.classic="classic"}(l||(l={}));const h=(t,e,n,i,s,r,o="rgb(100,100,100)",h=0,c=!1,u=1,m="",d=!1,f=l.classic,p={},g=0,y=null,b=[],w=null)=>{var v,C,S;s.textAlign="start";let M=r.substring(0),T=d?"":m;f===l.MSA&&(T="");let x=!0,E=!0,N="difference";null!=y&&null!=y.cell.column&&(x=null===(v=y.cell.column.temp["color-code"])||void 0===v||v,E=null===(C=y.cell.column.temp["compare-with-current"])||void 0===C||C,N=null!==(S=y.cell.column.temp["highlight-difference"])&&void 0!==S?S:"difference");const A=b[g];E&&b.length>0&&"difference"===N&&(u=M==A?.3:u),E&&b.length>0&&"equal"===N&&(u=M!=A?.3:u),null!=w&&(M=a(M,w));let I=s.measureText(M+T),L=s.measureText(M).width,k=s.measureText(M).width;const _=i/2-(I.fontBoundingBoxAscent+I.fontBoundingBoxDescent)/2+1;function R(n,i){const 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A=5,I=0,L=8;"short"===(null!=E?E:"short")&&(A=12,L=1);let k={};if(o.cell.column.getTag(".calculatedCellRender")!==C.toString()){let t=0;for(;t<Math.min(o.cell.column.length,100);)S(o.cell.column.get(t)).forEach(((t,e)=>{const n=7*f(t,L).length+A;n>(k[e]??0)&&(k[e]=n),e>I&&(I=e)})),t+=1;const e=21;for(let t=0;t<=I;t++){k[t]<e&&(k[t]=e);const n={};n[0]=k[0];for(let t=1;t<=I;t++)n[t]=n[t-1]+k[t];M["bio-sum-maxLengthWords"]=n,M["bio-maxIndex"]=I,M["bio-maxLengthWords"]=k,o.cell.column.setTag(".calculatedCellRender",C.toString())}}else k=M["bio-maxLengthWords"];const _=S(m.value);let R=e,O=d,G=l.classic;b&&b.includes("MSA")&&"separator"==y&&(G=l.MSA),_.every(((e,r)=>{O=w.get(e),t.fillStyle=d;const a=r===_.length-1;return R=h(R,n,i,s,t,e,O,0,!0,1,v,a,G,k,r,o,N,L),50<=i})),t.restore()}}class b extends r.GridCellRenderer{constructor(){super(...arguments),this.svgMolOptions={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0}}get name(){return c.Of.MONOMER}get cellType(){return c.Of.MONOMER}get 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r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.regionTypes=this.stringList("regionTypes",[E.CDR],{choices:Object.values(E).filter((t=>t!=E.Unknown))}),this.chains=this.stringList("chains",["Heavy","Light"],{choices:["Heavy","Light"]}),this.skipEmptyPositions=this.bool("skipEmptyPositions",!1),this.positionWidth=this.float("positionWidth",16),this.positionHeight=this.string("positionHeight",x.ES.Entropy,{choices:Object.keys(x.ES)})}async init(){this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.subs.push(M.fromEvent(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}async onTableAttached(){const t=super.onTableAttached.bind(this);this.viewPromise=this.viewPromise.then((async()=>{t(),this.viewed||(await this.buildView("onTableAttached"),this.viewed=!0)}))}onPropertyChanged(t){if(super.onPropertyChanged(t),t)switch(t&&t.name,t.name){case"skipEmptyPositions":case"positionWidth":case"positionHeight":this.setData(this.dataFrame,this.regions)}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){console.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})),this.regions=e,this.dataFrame=t,this.viewPromise=this.viewPromise.then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)}))}detach(){const t=super.detach.bind(this);this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}async destroyView(t){console.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){console.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort();this.logos=[];for(let t=0;t<n.length;t++){const i={};for(const s of this.chains){const r=e.find((e=>e.order==n[t]&&e.chain==s));i[s]=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight})}this.logos[t]=i}this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, 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end")}calcSize(){const t=(this.root.clientHeight-54)/this.chains.length,e=Math.min(t,Math.max(...this.logos.map((t=>Math.max(...Object.values(t).map((t=>t.maxHeight)))))));for(let t=0;t<this.logos.length;t++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[t][i].root.style.height=`${e}px`}}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?x.Ct.Selected:x.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let n=0;n<this.chains.length;n++){const i=this.chains[n];this.logos[e][i].setOptions({[T.bo.filterSource]:t})}}}var A=n(9017),I=n(850);async function L(t,e,i,s,r){const o=await async function(t,e,i,s){return new Promise((function(r,o){const a=new Worker(new URL(n.p+n.u(729),n.b));a.postMessage({columnData:t.data,method:e,measure:t.metric,options:i,parallelDistanceWorkers:s}),a.onmessage=({data:{error:t,distance:e,embedding:n}})=>{t?o(t):r({distance:e,embedding:n}),setTimeout((()=>a.terminate()),0)}}))}({data:t,metric:i},e,s,r);return o.embedding=o.embedding.map((t=>(0,I.Fv)(t))),o}var k=n(7983),_=n(499),R=n(7767),O=n(489);async function G(t){const e=new R.L(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let n=O.U.LEVENSHTEIN,i=t.seqCol.toList();if(e.isSeparator()){const t=e.convert("fasta");i=t.toList(),n=_.C.getOrCreate(t).getDistanceFunctionName()}else n=e.getDistanceFunctionName();for(let e=0;e<i.length;e++)i[e]=t.seqCol.isNone(e)?null:i[e];const s=await L(i,t.methodName,n,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,s.embedding[e])));return{distance:s.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,k.HV)(t.seqCol,!1),await i.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function P(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}var F=n(5697),W=n(3379),V=n.n(W),H=n(7795),Z=n.n(H),U=n(569),D=n.n(U),B=n(3565),Y=n.n(B),z=n(9216),X=n.n(z),q=n(4589),K=n.n(q),j=n(9414),$={};$.styleTagTransform=K(),$.setAttributes=Y(),$.insert=D().bind(null,"head"),$.domAPI=Z(),$.insertStyleElement=X(),V()(j.Z,$),j.Z&&j.Z.locals&&j.Z.locals;var J=n(3914),Q=n(6254);let tt=0;const et="cliffsDf",nt=new M.Subject,it="act_diff",st="sali",rt="sim",ot="line_index",at=["1_seq","2_seq"],lt="filterCliffs";function ht(t,e,n){const i=e.getBoundingClientRect(),s=t.clientX-i.left,r=t.clientY-i.top;let o=null,a=0;for(const t of n){const e=Math.abs(Math.hypot(t.a[0]-s,t.a[1]-r)+Math.hypot(t.b[0]-s,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var ct=n(1040);async function ut(t,e,n,s,o){e.version!==e.temp["last-invalidated-version"]&&await(0,k.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(s).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:s,simArr:o})}function mt(t){const e=s.divH([]),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.line.mols.forEach(((n,i)=>{const r=s.divText(t.activityCol.get(n).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),r]))})),e}function dt(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2),i=new Array(2);t.line.mols.forEach(((e,s)=>{n[s]=t.seqCol.get(e),i[s]=t.activityCol.get(e)}));const o={},a=t.seqCol.getTag(r.TAGS.UNITS),l=t.seqCol.getTag("separator"),h=(0,u.vU)(a,l),c=pt(h(n[0]),h(n[1]),a,o);return e.append(s.div(c,{style:{width:"300px",overflow:"scroll"}})),e.append(gt(o)),e.append(ft("Activity delta",Math.abs(i[0]-i[1]))),e.append(ft("Cliff",t.sali)),e}function ft(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function pt(t,e,n,i){const s=document.createElement("canvas"),r=s.getContext("2d");return s.height=30,v(r,0,0,0,30,t,e,n,!0,i),s}function gt(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function yt(t,e){const n=r.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),n.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}n(7861);var bt=n(4004),wt=n(7228),vt=n(1731),Ct=n(5226);n(9133);class St extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",F.kg[0],{choices:F.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((async t=>await this.render())));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((async e=>await this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((async t=>await this.render(!1)))),this.subs.push(r.debounce(s.onSizeChanged(this.root),50).subscribe((async t=>await this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}await this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}async render(t=!0){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Mt=n(7241),Tt=n(4293),xt=n(2669);async function Et(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=_.C.getOrCreate(t).getDistanceFunctionName(),i=new xt.m(!0,!1),s=await i.calc(e,n);return i.terminate(),s}function Nt(t){return(e,n)=>{const i=(e,n)=>t*e+n-Math.floor((e+2)*(e+1)/2);return e<=n?i(e,n):i(n,e)}}class At extends St{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new M.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async render(t=!0){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=_.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const s=n.plot.grid();s.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));s.cell("score",o).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Tt.Y)(this.root,s.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Mt.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Et(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=_.C.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(n.p+n.u(190),n.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,n)=>{const r=Math.floor(n*i.length/o),u=n===a.length-1?Math.floor((n+1)*i.length/o):i.length;return new Promise(((n,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:s}})=>{t?o(t):(h=Math.min(h,i),c=Math.max(c,s),l.set(e,r),n())},t.postMessage({fnName:s,values:i,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=Nt(e),s=Array(e).fill(0).map(((e,n)=>({idx:n,score:n===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,n)]:1-t[n]})));s.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=s.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=s.div(),n={},o=this.molCol?.name,a=t.col(o).getTag(r.TAGS.UNITS),l=t.col(o).getTag("separator"),h=(0,u.vU)(a,l),c=h(this.moleculeColumn.get(this.targetMoleculeIdx)),m=h(t.get(o,t.currentRowIdx)),d=pt(c,m,a,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==m.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${m.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(gt(n));const f=s.accordion(),p=s.element("i");p.className="grok-icon svg-icon svg-view-layout",f.addTitle(s.span([p,s.label("Similarity search")])),f.addPane("Differences",(()=>e),!0),i.shell.o=f.root}}var It=n(8518);class Lt extends St{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new M.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async render(t=!0){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=_.C.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));n.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>n.setTag(t,this.moleculeColumn.getTag(t))));const i=r.DataFrame.fromColumns([n]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Tt.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Mt.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Et(this.moleculeColumn),e=this.moleculeColumn.length,n=Nt(e);this.renderMolIds=(0,It.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[n(e,i)]))}}var kt=n(9943),_t=n(4413),Rt=n(1061),Ot=n(1345),Gt=n(116);const Pt={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class Ft{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}constructor(t){this.methodSettingsDiv=s.inputs([]),this.methodsParams={[Gt.AL.UMAP]:new Gt.bD,[Gt.AL.T_SNE]:new Gt.aP},this.tableInput=s.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=s.columnInput(Pt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:t=>t.semType===r.SEMTYPE.MOLECULE}),this.molColInputRoot=this.molColInput.root,this.methodInput=s.choiceInput("Method",Gt.AL.UMAP,[Gt.AL.UMAP,Gt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);let e=!1;this.similarityMetricInput=s.choiceInput("Similarity",ct.gk.Tanimoto,F.Rt)}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],r=s.floatInput(i.uiName,i.value,(()=>{i.value=r.value}));s.tooltip.bind(r.root,i.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=s.columnInput(Pt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),s.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Wt extends Ft{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=s.boolInput("Plot Embeddings",!0),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Vt extends Ft{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.activitiesInput=s.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(this.tableInput.value.columns.numerical),null,{filter:t=>t.type===r.TYPE.INT}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.intInput("Similarity cutoff",80),s.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=s.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),s.empty(this.activitiesInputRoot),this.activitiesInput=s.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(this.tableInput.value.columns.numerical),null,{filter:t=>t.type===r.TYPE.INT}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Ht,Zt=function(t,e,n,i){return new(n||(n=Promise))((function(s,r){function o(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?s(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(o,a)}l((i=i.apply(t,e||[])).next())}))};class Ut{constructor(t,e,n=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Ut.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,n;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const s=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,s,""),(null===(e=null===(t=s.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(n=s.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return Zt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=n,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),yield this._countdown(n,i,a),yield(0,Rt.gw)(a);const l=s.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Zt(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Zt(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas 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re{constructor(){this._funcName=""}async init(t,e){this._funcName=e,this.df=t,await this.buildView()}async buildView(){this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${oe.name}.${this._funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:"sequence"});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}const oe=new r.Package;function ae(){return Ot.NT.instance}let le=null;class he{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function ce(){await Ot.NT.instance.loadLibraries();const t=Ot.NT.instance.getBioLib(),e=[],n=[],s=await i.functions.call("Chem:getRdKitModule"),r=t.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((t=>{e.push(t);const i=r[t].replaceAll("#R","O "),o=s.get_mol(i),a=JSON.parse(o.get_descriptors()).CrippenClogP;n.push(a),o?.delete()}));const o=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let 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h=P(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const n=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],s=[];let r=0;for(let e=0;e<t.rowCount;e++)n.includes(i[e])&&(t.rows.removeAt(e-r),s.push(e),r+=1);return s}(c,e),m={seqCol:c.col(e.name),methodName:n,similarityMetric:o,embedAxesNames:h,options:l},d=n===Gt.AL.UMAP?1e5:15e3,f=n===Gt.AL.UMAP?5e3:2e3;if(t.rowCount>d)i.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>f))return p(await G(m));s.dialog().add(s.divText("Sequence space analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await G(m);return t.close(),p(e)})).show()}function p(e){const n=e.coordinates;for(const e of n){const n=e.toList();u.forEach((t=>n.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>n[t])))}if(a)return i.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function Ee(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,ie.n)(e,"To Atomic Level"))return;const n=(await ae()).getBioLib(),o=await(0,vt.i0)(t,e,n);null!==o.col&&(t.columns.add(o.col,!0),await i.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&i.shell.warning(s.list(o.warnings))}function Ne(){(0,se.K)()}async function Ae(t=null,e=null){return(0,se.K)({col:t,clustersCol:e})}async function Ie(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(_.C.getOrCreate(t),!0))),n=async e=>{if(!(0,ie.n)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(n,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>_.C.getOrCreate(t).isMsa())),r=s.choiceInput("Column",i?i.name:t[0],t);s.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(s.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await n(t)})).show()}else o=e[0];o&&await n(o)}else i.shell.error("Current table does not contain sequences")}async function Le(t){(0,wt.Xk)(t)}function ke(t){return new Ct.i(t).importFasta()}function _e(){const t=(0,Tt.m)();(0,bt.O)(t)}function Re(){return new b}async function Oe(t){const e=r.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let s=0;const o=[];for(const a of n)try{const e=await i.dapi.files.readAsText(t+a.fullPath),n=r.DataFrame.fromCsv(e);for(const t of n.columns)await i.functions.call("Bio:detectMacromolecule",{col:t})===r.SEMTYPE.MACROMOLECULE&&o.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(r.TAGS.UNITS)}`})}catch(t){o.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{s+=1,e.update(100*s/n.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}function Ge(){const t=(0,Tt.m)(),e=function(t){const e=(0,o.Mj)(t),n=t=>{const e=a.columns.addNewString((t+1).toString());return i.push(e),e},i=[],s=t.length,a=r.DataFrame.create(s);for(let r=0;r<s;++r){const s=t.get(r);null!=s&&e(s).forEach(((t,e)=>{var s;((null!==(s=i[e])&&void 0!==s?s:null)||n(e)).set(r,t||"-",!1)}))}return a}(t),n=t.dataFrame;for(const i of e.columns){const e=n.columns.add(i);e.semType=c.Of.MONOMER,e.setTag("alphabet",t.getTag("alphabet"))}i.shell.tv.grid.invalidate()}function Pe(t){const e=_.C.getOrCreate(t).stats;return Object.keys(e.freq)}function Fe(){return new At}function We(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Ve(){return new Lt}function He(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Ze(){const t=(0,Tt.m)();(0,k.gQ)(t)}function Ue(){(0,kt.C2)()}function De(){return new _t.ST}async function Be(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new re,e=await oe.files.readCsv("data/sample_PT_10000.csv");await i.data.detectSemanticTypes(e),await t.init(e,"webLogoLargeApp")}finally{t.close()}}async function Ye(){await async function(){let t,e;try{const n=new Ut("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await n.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await oe.files.readCsv(Bt),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const n=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(n,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(n,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){Dt(t)}}()}async function ze(){await async function(){let t,e,n,s,o;try{const a=new Ut("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[s,t,e]=await Promise.all([oe.files.readCsv(jt),Xt(),Kt()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,n,i){let s;{const t=Object.values(Ht);for(let n=0;n<t.length;n++){const i=t[n];if(!e.col(i)){const s=n==t.length-1;e.columns.add(r.Column.float(i,e.rowCount),s)}}if(e.rowCount>=1){const i=e.getCol(n).toList(),s=Date.now();oe.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await L(i,"UMAP",ct.W.Levenshtein,{}),o=Date.now();oe.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-s)/1e3} s`);for(let n=0;n<t.length;n++){const i=t[n],s=e.getCol(i),o=r.embedding[n];s.init((t=>o[t]))}const a=Date.now();oe.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}s=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Ht.X,yColumnName:Ht.Y,lassoTool:!0})}return t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),s}(n,s,$t)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=s.getCol($t).toList(),r=J.H.calc(i,((t,e)=>Yt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(n.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{s.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=s.getCol("sequence_id");s.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),s.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){Dt(t)}}()}async function Xe(){await async function(){let t,e,n,s,o;const a=Gt.AL.UMAP;try{const l=new Ut("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[n,t,e]=await Promise.all([oe.files.readCsv(te),Xt(),Kt()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=300,s.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await Me(n,n.getCol("Sequence"),n.getCol("Activity"),80,a),s.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),Qt()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol("sequence").toList(),r=J.H.calc(i,((t,e)=>Yt.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0),s.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){Dt(t)}}()}async function qe(){await async function(){const t="HELM";let e,n,o;try{await new Ut("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await oe.files.readCsv("samples/sample_HELM.csv"),n=i.shell.addTableView(e);for(let e=0;e<n.grid.columns.length;e++){const i=n.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=e.getCol(t);await Ee(e,n)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${t})`;e.currentCell=e.cell(1,n);const i=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),o=s.dialog().add(a).show(),await(0,Rt.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){Dt(t)}}()}async function Ke(){await async function(){let t,e,n,s,o,a;const l="msa(HELM)",h=Gt.AL.UMAP;try{const c=new Ut("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await oe.files.readCsv(ne)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{n=e.getCol("HELM");const t=ee.J[0];s=await(0,ee.f)(n,l,t,1.53,0,void 0),e.columns.add(s),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await xe(e,s,h,O.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){Dt(t)}}()}},9017:(t,e,n)=>{"use strict";n.d(e,{k:()=>r});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class s{constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=r+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:r+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const s=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[s][e].parentJ}return new s(n,i,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let s=1;s<=this.len2;s++)this.fillOne(i,s),this.dpGrid[i][s].value<=0?(this.dpGrid[i][s].value=0,this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0):0==this.dpGrid[this.dpGrid[i][s].parentI][this.dpGrid[i][s].parentJ].value&&(this.dpGrid[i][s].parentI=0,this.dpGrid[i][s].parentJ=0),this.dpGrid[i][s].value>t&&(t=this.dpGrid[i][s].value,e=i,n=s);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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y{constructor(t,e,n={},i=0,s=0){this.pos=t,this.name=e,this.freq=n,this.rowCount=i,this.sumForHeightCalc=s}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(f||(f={}));const b=u.vS;class w extends r.JsViewer{get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionWidthWithMargin(){return this._positionWidth+this.positionMarginValue}get positionMarginValue(){return"auto"===this.positionMarginState&&!0===this.unitsHandler?.getAlphabetIsMultichar()||"enable"===this.positionMarginState?this.positionMargin:0}get countOfRenderPositions(){if(null==this.host)return 0;const t=window.devicePixelRatio;return t>1?this.canvasWidthWithRatio/this.positionWidthWithMargin:this.canvas.width/(this.positionWidthWithMargin*t)}get canvasWidthWithRatio(){return this.canvas.width*window.devicePixelRatio}get firstVisibleIndex(){return this.visibleSlider?Math.floor(this.slider.min):0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.axisHeight=12,this.seqCol=null,this.positions=[],this.rowsMasked=0,this.rowsNull=0,this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.viewSubs=[],this.viewerId=w.viewerCount,w.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(f.sequenceColumnName,b.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(f.startPositionName,b.startPositionName,{category:d.DATA}),this.endPositionName=this.string(f.endPositionName,b.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(f.skipEmptySequences,b.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(f.skipEmptyPositions,b.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(f.shrinkEmptyTail,b.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(f.backgroundColor,b.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(f.positionHeight,b.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(f.positionWidth,b.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(f.verticalAlignment,b.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(f.horizontalAlignment,b.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(f.fixWidth,b.fixWidth,{category:d.LAYOUT}),this.fitArea=this.bool(f.fitArea,b.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(f.minHeight,b.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(f.maxHeight,b.maxHeight,{category:d.LAYOUT}),this.positionMarginState=this.string(f.positionMarginState,b.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(f.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(f.filterSource,b.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=s.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=s.canvas(),this.canvas.style.width="100%"}init(){this.initialized?p._package.logger.error("Bio: WebLogoViewer.init() second initialization!"):(this.initialized=!0,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=s.div("No message"),this.msgHost.style.display="none",this.canvas=s.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.subs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.host=s.div([this.msgHost,this.canvas]),this.host.style.justifyContent="center",this.host.style.alignItems="center",this.host.style.position="relative",this.host.style.setProperty("overflow","hidden","important"),this.subs.push(l.fromEvent(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.subs.push(l.fromEvent(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.subs.push(l.fromEvent(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.subs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.root.append(this.host),this.root.append(this.slider.root),this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0))}setData(){this.viewed&&(this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.viewed||(this.buildView(),this.viewed=!0)}destroyView(){const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),super.detach(),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,this.initialized=!1,p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}buildView(){super.onTableAttached();const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached( dataFrame = ${t} ) start`),void 0!==this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.init(),p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached() end`)}rootOnSizeChanged(){this._calculate(window.devicePixelRatio),this.updateSlider(),this.render(!0)}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqCol.getTag(r.TAGS.UNITS),this.seqCol.getTag("separator"),this.unitsHandler=h.C.getOrCreate(this.seqCol),this.updatePositions(),this.cp=(0,c.dQ)(this.seqCol)}catch(t){this.seqCol=null,this.msgHost.innerText=`${t}`,this.msgHost.style.setProperty("display",null)}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}this.render()}updatePositions(){if(!this.seqCol)return;let t;if(this.shrinkEmptyTail){const e=this.dataFrame.filter.getSelectedIndexes();t=Array.from(new Set(Array.from(Array(e.length).keys()).map((t=>this.seqCol.get(e[t])))))}else t=this.seqCol.categories;const e=t.length>0?Math.max(...this.unitsHandler.splitted.map((t=>t.length))):0,n=this.seqCol.getTag(u.DX.positionNames);this.positionNames=n?n.split(u.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1}get widthArea(){return this.Length*this.positionWidth/window.devicePixelRatio}get heightArea(){return Math.min(this.maxHeight,Math.max(this.minHeight,this.root.clientHeight))}get xScale(){return this.widthArea>0?(this.root.clientWidth-this.Length*this.positionMarginValue)/this.widthArea:0}get yScale(){return this.root.clientHeight/this.heightArea}checkIsHideSlider(){let t=!0;const e=Math.min(this.xScale,this.yScale);return(e==this.xScale||e<=1)&&this.fitArea&&(t=!1),this.fixWidth||Math.ceil(this.canvas.width/this.positionWidthWithMargin)>=this.Length||t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}updateSlider(){if(this.checkIsHideSlider()?this.setSliderVisibility(!1):this.setSliderVisibility(!0),null!=this.slider&&null!=this.canvas){const t=Math.max(0,Math.floor(this.slider.min+this.canvas.width/this.positionWidthWithMargin)-this.Length);let e=Math.floor(this.slider.min-t),n=Math.floor(this.slider.min-t)+Math.floor(this.canvas.width/this.positionWidthWithMargin);this.checkIsHideSlider()&&(e=0,n=Math.max(e,this.Length-1)),this.turnOfResizeForOneSetValue=!0,this.slider.setValues(0,this.Length,e,n)}}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case f.sequenceColumnName:case f.startPositionName:case f.endPositionName:case f.filterSource:this.updateSeqCol();break;case f.positionWidth:this._positionWidth=this.positionWidth,this.updateSlider();break;case f.fixWidth:case f.fitArea:case f.positionMargin:this.updateSlider();break;case f.shrinkEmptyTail:case f.skipEmptyPositions:this.updatePositions()}this.render(!0)}onTableAttached(){p._package.logger.debug("Bio: WebLogoViewer.onTableAttached(), "),super.onTableAttached(),this.setData()}async detach(){this.viewed&&(this.destroyView(),this.viewed=!1)}getMonomer(t){const e=t.x+this.firstVisibleIndex*this.positionWidthWithMargin,n=Math.floor(t.x/this.positionWidthWithMargin+this.firstVisibleIndex),i=this.positions[n];if(null==i)return[n,null,null];const s=Object.keys(i.freq).find((n=>i.freq[n].bounds.contains(e,t.y)));return void 0===s?[n,null,null]:[n,s,i.freq[s]]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}removeWhere(t,e){const n=t.length;let i=0;for(let s=0;s<n;s++)e(t[s])||(t[i]=t[s],i++);return t.length=i,t}_removeEmptyPositions(){this.skipEmptyPositions&&this.removeWhere(this.positions,(t=>t?.freq["-"]?.count===t.rowCount))}_calculate(t){if(!this.host||!this.seqCol||!this.dataFrame)return;this.unitsHandler=h.C.getOrCreate(this.seqCol),this.calcSize();const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let t=0;t<this.Length;t++){const e=this.positionNames[this.startPosition+t];this.positions[t]=new y(this.startPosition+t,e)}const n=this.filter.getSelectedIndexes();this.rowsMasked=n.length;for(const t of n){const e=this.unitsHandler.splitted[t];for(let t=0;t<this.Length;t++){const n=this.positions[t].freq,i=e[this.startPosition+t]||"-";i in n||(n[i]=new g),n[i].count++}}for(let t=0;t<this.Length;t++){this.positions[t].rowCount=0;for(const e in this.positions[t].freq)this.positions[t].rowCount+=this.positions[t].freq[e].count;if(this.positionHeight==u.ES.Entropy){this.positions[t].sumForHeightCalc=0;for(const e in this.positions[t].freq){const n=this.positions[t].freq[e].count/this.positions[t].rowCount;this.positions[t].sumForHeightCalc+=-n*Math.log2(n)}}}this._removeEmptyPositions();const s=this.canvas.height-this.axisHeight*t;for(let e=0;e<this.Length;e++){const n=this.positions[e].freq,o=this.positions[e].rowCount,a=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==a&&i.shell.error("WebLogo: alphabet is undefined.");const l=Math.log2(a),h=this.positionHeight==u.ES.Entropy?s*(l-this.positions[e].sumForHeightCalc)/l:s;let c=this.axisHeight*t+(s-h-1);const m=Object.entries(n).sort(((t,e)=>"-"!==t[0]&&"-"!==e[0]?e[1].count-t[1].count:"-"===t[0]&&"-"===e[0]?0:"-"===t[0]?-1:1));for(const t of m){const n=t[1],i=h*n.count/o;n.bounds=new r.Rect(e*this.positionWidthWithMargin,c,this._positionWidth,i),c+=i}}}render(t=!0){if(this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const n=window.devicePixelRatio;t&&this._calculate(n),e.resetTransform(),e.fillStyle=r.Color.toHtml(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const i=this.countOfRenderPositions+1,s=this.visibleSlider?Math.floor(this.slider.min):0,o=Math.min(this.Length,s+i),a=10*n;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth-2?1:(this._positionWidth-2)/l;for(let t=this.firstVisibleIndex;t<o;t++){const n=this.positions[t];e.resetTransform(),e.setTransform(h,0,0,1,t*this.positionWidthWithMargin+this._positionWidth/2-this.positionWidthWithMargin*s,0),e.fillText(n.name,0,0)}for(let t=this.firstVisibleIndex;t<o;t++)for(const[n,i]of Object.entries(this.positions[t].freq))if("-"!==n){const t=(0,c.GU)(n,5),s=i.bounds,r=s.left-this.positionWidthWithMargin*this.firstVisibleIndex;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(r,s.top,s.width,s.height),e.fillStyle=this.cp.get(n)??this.cp.get("other"),e.textAlign="left",e.font="16px Roboto, Roboto Local, sans-serif";const o=e.measureText(t);e.setTransform(s.width/o.width,0,0,s.height/12.2,r,s.top),e.fillText(t,0,-.25)}}calcSize(){if(!this.host)return;const t=window.devicePixelRatio;let e=this.widthArea,n=this.heightArea;if(this.fitArea&&!this.visibleSlider){const t=Math.max(1,Math.min(this.xScale,this.yScale));e*=t,n*=t,this._positionWidth=this.positionWidth*t}e=this.Length*this.positionWidthWithMargin/t,this.canvas.width=this.root.clientWidth*t,this.canvas.style.width=`${this.root.clientWidth}px`,this.host.style.setProperty("height",`${n}px`);const i=this.host.clientHeight;if(this.canvas.height=i*t,this.fixWidth)this.root.style.width=this.host.style.width=`${e}px`,this.root.style.height=`${n}px`,this.root.style.overflow="hidden",this.host.style.setProperty("overflow-y","hidden","important");else{this.root.style.width=this.host.style.width="100%",this.host.style.overflowX="auto!important",this.host.style.setProperty("text-align",this.horizontalAlignment);const t=this.visibleSlider?10:0;let s=0;switch(this.verticalAlignment){case"top":s=0;break;case"middle":s=Math.max(0,(this.root.clientHeight-n)/2);break;case"bottom":s=Math.max(0,this.root.clientHeight-n-t)}let r=0;switch(this.horizontalAlignment){case"left":r=0;break;case"center":r=Math.max(0,(this.root.clientWidth-e)/2);break;case"right":r=Math.max(0,this.root.clientWidth-e)}this.host.style.setProperty("margin-top",`${s}px`,"important"),this.host.style.setProperty("margin-left",`${r}px`,"important"),null!=this.slider&&this.slider.root.style.setProperty("margin-top",`${s+i}px`,"important"),this.root.clientHeight<=n?(this.host.style.setProperty("height",`${this.root.clientHeight}px`),this.host.style.setProperty("overflow-y",null)):this.host.style.setProperty("overflow-y","hidden","important")}}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){if(null!=this.host)try{if(this.allowResize&&!this.turnOfResizeForOneSetValue&&this.visibleSlider){const t=Math.ceil(this.slider.max-this.slider.min),e=this.canvas.width/t-this.positionMarginValue;this.positionWidth=e,this._positionWidth=e}this.turnOfResizeForOneSetValue=!1,this.render(!0)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.sliderOnValuesChanged() error:\n"+e)}}dataFrameFilterOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameFilterChanged()");try{this.updatePositions(),this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameFilterOnChanged() error:\n"+e)}}dataFrameSelectionOnChanged(t){p._package.logger.debug("Bio: WebLogoViewer.dataFrameSelectionOnChanged()");try{this.render()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.dataFrameSelectionOnChanged() error:\n"+e)}}canvasOnMouseMove(t){try{const e=t,n=window.devicePixelRatio,i=this.canvas.getCursorPosition(e,n),[r,o]=this.getMonomer(i);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],n=function(t,e,n,i,s){return a().count(0).take(t.rowCount).filter((t=>n.get(t))).map((t=>{const n=e.splitted[t],i=s.pos;return i<n.length?n[i]:null})).toArray().filter((t=>t==i)).reduce(((t,e)=>t+1),0)}(this.dataFrame,this.unitsHandler,this.filter,o,t),i=s.div([s.div(`${o}`),s.div(`${n} rows`)]);s.tooltip.show(i,e.x+16,e.y+16)}else s.tooltip.hide()}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseMove() error:\n"+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,s]=this.getMonomer(this.canvas.getCursorPosition(e,n));if(this.dataFrame&&this.seqCol&&this.unitsHandler&&s){const t=this.positions[i],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,n,i,s,r){if(!n.getSelectedIndexes().includes(i))return!1;const o=e.splitted[i],a=r.pos<o.length?o[r.pos]:null;return a===s||""===a&&"-"===s}(this.dataFrame,this.unitsHandler,this.filter,e,s,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnMouseDown() error:\n"+e)}}canvasOnWheel(t){try{if(!this.visibleSlider)return;const e=t.deltaY/100*Math.max(Math.floor(this.countOfRenderPositions/2),1);this.slider.scrollBy(this.slider.min+e)}catch(t){const e=m(t);p._package.logger.error("Bio: WebLogoViewer.canvasOnWheel() error:\n"+e)}}}w.residuesSet="nucleotides",w.viewerCount=-1},4413:(t,e,n)=>{"use strict";n.d(e,{ST:()=>d});var i=n(3870),s=n(976),r=n(4469),o=n(6414),a=n.n(o),l=n(7983),h=n(701),c=n(4293),u=n(1061);const m=rxjs.operators;class d extends s.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(s.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(s.TAGS.UNITS)),this.bioFilter="fasta"===this.notation?new p:"separator"===this.notation?new g(this.column.getTag("separator")):new y,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,m.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class f{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class p extends f{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class g extends p{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class y extends f{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:n}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const 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