@datagrok/bio 2.27.0 → 2.27.1

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (17) hide show
  1. package/dist/287.js +1 -1
  2. package/dist/287.js.map +1 -1
  3. package/dist/package-test.js +1 -1
  4. package/dist/package-test.js.map +1 -1
  5. package/dist/package.js +1 -1
  6. package/dist/package.js.map +1 -1
  7. package/package.json +1 -1
  8. package/scripts/mol-to-helm.py +642 -170
  9. package/src/analysis/sequence-activity-cliffs.ts +8 -6
  10. package/src/package-api.ts +2 -2
  11. package/src/package.ts +2 -1
  12. package/src/utils/annotations/annotation-manager-ui.ts +1 -1
  13. package/src/utils/monomer-lib/library-file-manager/ui.ts +1 -1
  14. package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +1 -1
  15. package/src/utils/multiple-sequence-alignment-ui.ts +2 -2
  16. package/test-console-output-1.log +546 -538
  17. package/test-record-1.mp4 +0 -0
package/dist/package.js CHANGED
@@ -4,5 +4,5 @@ var bio;(()=>{var e,t,n={8924(e,t,n){"use strict";var i=n(7362);class o extends
4
4
  || ${a} === "boolean" || ${o} === null`).assign(l,s._`[${o}]`)}}i.else(),p(e),i.endIf(),i.if(s._`${l} !== undefined`,()=>{i.assign(o,l),function({gen:e,parentData:t,parentDataProperty:n},i){e.if(s._`${t} !== undefined`,()=>e.assign(s._`${t}[${n}]`,i))}(e,l)})}(e,t,a):p(e)})}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,i=l.Correct){const o=i===l.Correct?s.operators.EQ:s.operators.NEQ;let r;switch(e){case"null":return s._`${t} ${o} null`;case"array":r=s._`Array.isArray(${t})`;break;case"object":r=s._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":r=a(s._`!(${t} % 1) && !isNaN(${t})`);break;case"number":r=a();break;default:return s._`typeof ${t} ${o} ${e}`}return i===l.Correct?r:(0,s.not)(r);function a(e=s.nil){return(0,s.and)(s._`typeof ${t} == "number"`,e,n?s._`isFinite(${t})`:s.nil)}}function d(e,t,n,i){if(1===e.length)return h(e[0],t,n,i);let o;const r=(0,a.toHash)(e);if(r.array&&r.object){const e=s._`typeof ${t} != "object"`;o=r.null?e:s._`!${t} || ${e}`,delete r.null,delete r.array,delete r.object}else o=s.nil;r.number&&delete r.integer;for(const e in r)o=(0,s.and)(o,h(e,t,n,i));return o}t.checkDataType=h,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?s._`{type: ${e}}`:s._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:n,schema:i}=e,o=(0,a.schemaRefOrVal)(e,i,"type");return{gen:t,keyword:"type",data:n,schema:i.type,schemaCode:o,schemaValue:o,parentSchema:i,params:{},it:e}}(e);(0,r.reportError)(t,m)}t.reportTypeError=p},7870(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const i=n(9029),o=n(4227);function r(e,t,n){const{gen:r,compositeRule:s,data:a,opts:l}=e;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(t)}`;if(s)return void(0,o.checkStrictMode)(e,`default is ignored for: ${c}`);let u=i._`${c} === undefined`;"empty"===l.useDefaults&&(u=i._`${u} || ${c} === null || ${c} === ""`),r.if(u,i._`${c} = ${(0,i.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:i}=e.schema;if("object"===t&&n)for(const t in n)r(e,t,n[t].default);else"array"===t&&Array.isArray(i)&&i.forEach((t,n)=>r(e,n,t.default))}},2586(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const i=n(8727),o=n(208),r=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),u=n(9029),h=n(2023),d=n(6939),m=n(4227),p=n(8708);function g({gen:e,validateName:t,schema:n,schemaEnv:i,opts:o},r){o.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,i.$async,()=>{e.code(u._`"use strict"; ${f(n,o)}`),function(e,t){e.if(h.default.valCxt,()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)},()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)})}(e,o),e.code(r)}):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(o)}`,i.$async,()=>e.code(f(n,o)).code(r))}function f(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,m.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:i,self:o}=e;t.$ref&&i.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(t,o.RULES)&&o.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return A(e,[],!1,t);const n=(0,o.getSchemaTypes)(e.schema);A(e,n,!(0,o.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:i,opts:o}){const r=n.$comment;if(!0===o.$comment)e.code(u._`${h.default.self}.logger.log(${r})`);else if("function"==typeof o.$comment){const n=u.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function A(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:p}=e,{RULES:g}=p;function f(m){(0,r.shouldUseGroup)(a,m)&&(m.type?(o.if((0,s.checkDataType)(m.type,l,d.strictNumbers)),S(e,m),1===t.length&&t[0]===m.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):S(e,m),c||o.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(a,g)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach(t=>{x(e.dataTypes,t)||E(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)}),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&E(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const i in n){const o=n[i];if("object"==typeof o&&(0,r.shouldUseRule)(e.schema,o)){const{type:n}=o.definition;n.length&&!n.some(e=>{return i=e,(n=t).includes(i)||"number"===i&&n.includes("integer");var n,i})&&E(e,`missing type "${n.join(",")}" for keyword "${i}"`)}}}(e,e.dataTypes))}(e,t),o.block(()=>{for(const e of g.rules)f(e);f(g.post)})):o.block(()=>T(e,"$ref",g.all.$ref.definition))}function S(e,t){const{gen:n,schema:i,opts:{useDefaults:o}}=e;o&&(0,a.assignDefaults)(e,t.type),n.block(()=>{for(const n of t.rules)(0,r.shouldUseRule)(i,n)&&T(e,n.keyword,n.definition,t.type)})}function x(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function E(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,m.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:i}=e;g(e,()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,m.checkStrictMode)(e,"default is ignored in the schema root")}(e),i.let(h.default.vErrors,null),i.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`)),t.if(u._`${e.evaluated}.dynamicItems`,()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:i,ValidationError:o,opts:r}=e;n.$async?t.if(u._`${h.default.errors} === 0`,()=>t.return(h.default.data),()=>t.throw(u._`new ${o}(${h.default.vErrors})`)):(t.assign(u._`${i}.errors`,h.default.vErrors),r.unevaluated&&function({gen:e,evaluated:t,props:n,items:i}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),i instanceof u.Name&&e.assign(u._`${t}.items`,i)}(e),t.return(u._`${h.default.errors} === 0`))}(e)})}(e):g(e,()=>(0,i.topBoolOrEmptySchema)(e))};class M{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,m.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",_(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",h.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?p.reportExtraError:p.reportError)(this,this.def.error,t)}$dataError(){(0,p.reportError)(this,this.def.$dataError||p.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,p.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block(()=>{this.check$data(e,n),t()})}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:i,schemaType:o,def:r}=this;n.if((0,u.or)(u._`${i} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(o.length||r.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:i,it:o}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,s.checkDataTypes)(e,t,o.opts.strictNumbers,s.DataType.Wrong)}`}return u.nil}(),function(){if(i.validateSchema){const n=e.scopeValue("validate$data",{ref:i.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,c.getSubschema)(this.it,e);(0,c.extendSubschemaData)(n,this.it,e),(0,c.extendSubschemaMode)(n,e);const o={...this.it,...n,items:void 0,props:void 0};return function(e,t){b(e)&&(v(e),y(e))?function(e,t){const{schema:n,gen:i,opts:o}=e;o.$comment&&n.$comment&&C(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,d.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const r=i.const("_errs",h.default.errors);w(e,r),i.var(t,u._`${r} === ${h.default.errors}`)}(e,t):(0,i.boolOrEmptySchema)(e,t)}(o,t),o}mergeEvaluated(e,t){const{it:n,gen:i}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=m.mergeEvaluated.props(i,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=m.mergeEvaluated.items(i,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:i}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return i.if(t,()=>this.mergeEvaluated(e,u.Name)),!0}}function T(e,t,n,i){const o=new M(e,n,t);"code"in n?n.code(o,i):o.$data&&n.validate?(0,l.funcKeywordCode)(o,n):"macro"in n?(0,l.macroKeywordCode)(o,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(o,n)}t.KeywordCxt=M;const I=/^\/(?:[^~]|~0|~1)*$/,L=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function _(e,{dataLevel:t,dataNames:n,dataPathArr:i}){let o,r;if(""===e)return h.default.rootData;if("/"===e[0]){if(!I.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);o=e,r=h.default.rootData}else{const s=L.exec(e);if(!s)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+s[1];if(o=s[2],"#"===o){if(a>=t)throw new Error(l("property/index",a));return i[t-a]}if(a>t)throw new Error(l("data",a));if(r=n[t-a],!o)return r}let s=r;const a=o.split("/");for(const e of a)e&&(r=u._`${r}${(0,u.getProperty)((0,m.unescapeJsonPointer)(e))}`,s=u._`${s} && ${r}`);return s;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=_},3673(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const i=n(9029),o=n(2023),r=n(5765),s=n(8708);function a(e){const{gen:t,data:n,it:o}=e;t.if(o.parentData,()=>t.assign(n,i._`${o.parentData}[${o.parentDataProperty}]`))}function l(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,i.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:o,schema:r,parentSchema:s,it:a}=e,c=t.macro.call(a.self,r,s,a),u=l(n,o,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const h=n.name("valid");e.subschema({schema:c,schemaPath:i.nil,errSchemaPath:`${a.errSchemaPath}/${o}`,topSchemaRef:u,compositeRule:!0},h),e.pass(h,()=>e.error(!0))},t.funcKeywordCode=function(e,t){var n;const{gen:c,keyword:u,schema:h,parentSchema:d,$data:m,it:p}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(p,t);const g=!m&&t.compile?t.compile.call(p.self,h,d,p):t.validate,f=l(c,u,g),y=c.let("valid");function b(n=(t.async?i._`await `:i.nil)){const s=p.opts.passContext?o.default.this:o.default.self,a=!("compile"in t&&!m||!1===t.schema);c.assign(y,i._`${n}${(0,r.callValidateCode)(e,f,s,a)}`,t.modifying)}function v(e){var n;c.if((0,i.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,function(){if(!1===t.errors)b(),t.modifying&&a(e),v(()=>e.error());else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try(()=>b(i._`await `),t=>c.assign(y,!1).if(i._`${t} instanceof ${p.ValidationError}`,()=>c.assign(e,i._`${t}.errors`),()=>c.throw(t))),e}():function(){const e=i._`${f}.errors`;return c.assign(e,null),b(i.nil),e}();t.modifying&&a(e),v(()=>function(e,t){const{gen:n}=e;n.if(i._`Array.isArray(${t})`,()=>{n.assign(o.default.vErrors,i._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`).assign(o.default.errors,i._`${o.default.vErrors}.length`),(0,s.extendErrors)(e)},()=>e.error())}(e,n))}}),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some(t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e)},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:i},o,r){if(Array.isArray(o.keyword)?!o.keyword.includes(r):o.keyword!==r)throw new Error("ajv implementation error");const s=o.dependencies;if(null==s?void 0:s.some(t=>!Object.prototype.hasOwnProperty.call(e,t)))throw new Error(`parent schema must have dependencies of ${r}: ${s.join(",")}`);if(o.validateSchema&&!o.validateSchema(e[r])){const e=`keyword "${r}" value is invalid at path "${i}": `+n.errorsText(o.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},4495(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const i=n(9029),o=n(4227);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:r,schemaPath:s,errSchemaPath:a,topSchemaRef:l}){if(void 0!==t&&void 0!==r)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const r=e.schema[t];return void 0===n?{schema:r,schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:r[n],schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}${(0,i.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,o.escapeFragment)(n)}`}}if(void 0!==r){if(void 0===s||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:r,schemaPath:s,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:r,data:s,dataTypes:a,propertyName:l}){if(void 0!==s&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=t;if(void 0!==n){const{errorPath:s,dataPathArr:a,opts:l}=t;u(c.let("data",i._`${t.data}${(0,i.getProperty)(n)}`,!0)),e.errorPath=i.str`${s}${(0,o.getErrorPath)(n,r,l.jsPropertySyntax)}`,e.parentDataProperty=i._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==s&&(u(s instanceof i.Name?s:c.let("data",s,!0)),void 0!==l&&(e.propertyName=l)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:i,createErrors:o,allErrors:r}){void 0!==i&&(e.compositeRule=i),void 0!==o&&(e.createErrors=o),void 0!==r&&(e.allErrors=r),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var o=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return o.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return o.CodeGen}});const r=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),u=n(6939),h=n(208),d=n(4227),m=n(3837),p=n(5944),g=(e,t)=>new RegExp(e,t);g.code="new RegExp";const f=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function w(e){var t,n,i,o,r,s,a,l,c,u,h,d,m,f,y,b,v,w,C,A,S,x,E,M,T;const I=e.strict,L=null===(t=e.code)||void 0===t?void 0:t.optimize,_=!0===L||void 0===L?1:L||0,N=null!==(i=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==i?i:g,P=null!==(o=e.uriResolver)&&void 0!==o?o:p.default;return{strictSchema:null===(s=null!==(r=e.strictSchema)&&void 0!==r?r:I)||void 0===s||s,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:I)||void 0===l||l,strictTypes:null!==(u=null!==(c=e.strictTypes)&&void 0!==c?c:I)&&void 0!==u?u:"log",strictTuples:null!==(d=null!==(h=e.strictTuples)&&void 0!==h?h:I)&&void 0!==d?d:"log",strictRequired:null!==(f=null!==(m=e.strictRequired)&&void 0!==m?m:I)&&void 0!==f&&f,code:e.code?{...e.code,optimize:_,regExp:N}:{optimize:_,regExp:N},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:200,meta:null===(v=e.meta)||void 0===v||v,messages:null===(w=e.messages)||void 0===w||w,inlineRefs:null===(C=e.inlineRefs)||void 0===C||C,schemaId:null!==(A=e.schemaId)&&void 0!==A?A:"$id",addUsedSchema:null===(S=e.addUsedSchema)||void 0===S||S,validateSchema:null===(x=e.validateSchema)||void 0===x||x,validateFormats:null===(E=e.validateFormats)||void 0===E||E,unicodeRegExp:null===(M=e.unicodeRegExp)||void 0===M||M,int32range:null===(T=e.int32range)||void 0===T||T,uriResolver:P}}class C{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...w(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return I;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const i=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,e,"NOT SUPPORTED"),A.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=T.call(this),e.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&M.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),x.call(this),e.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let i=m;"id"===n&&(i={...m},i.id=i.$id,delete i.$id),t&&e&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const i=n(t);return"$async"in n||(this.errors=n.errors),i}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return i.call(this,e,t);async function i(e,t){await o.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||r.call(this,n)}async function o(e){e&&!this.getSchema(e)&&await i.call(this,{$ref:e},!0)}async function r(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof s.default))throw t;return a.call(this,t),await l.call(this,t.missingSchema),r.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function l(e){const n=await c.call(this,e);this.refs[e]||await o.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function c(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,i=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,i);return this}let o;if("object"==typeof e){const{schemaId:t}=this.opts;if(o=e[t],void 0!==o&&"string"!=typeof o)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||o),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,i,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const i=this.validate(n,e);if(!i&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return i}getSchema(e){let t;for(;"string"==typeof(t=S.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,i,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=S.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(_.call(this,n,t),!t)return(0,d.eachItem)(n,e=>N.call(this,e)),this;R.call(this,t);const i={...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)};return(0,d.eachItem)(n,0===i.type.length?e=>N.call(this,e,i):e=>i.type.forEach(t=>N.call(this,e,i,t))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex(t=>t.keyword===e);t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map(e=>`${n}${e.instancePath} ${e.message}`).reduce((e,n)=>e+t+n):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const i of t){const t=i.split("/").slice(1);let o=e;for(const e of t)o=o[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:i}=t.definition,r=o[e];i&&r&&(o[e]=O(r))}}return e}_removeAllSchemas(e,t){for(const n in e){const i=e[n];t&&!t.test(n)||("string"==typeof i?delete e[n]:i&&!i.meta&&(this._cache.delete(i.schema),delete e[n]))}}_addSchema(e,t,n,i=this.opts.validateSchema,o=this.opts.addUsedSchema){let r;const{schemaId:s}=this.opts;if("object"==typeof e)r=e[s];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(r||n);const c=u.getSchemaRefs.call(this,e,n);return a=new l.SchemaEnv({schema:e,schemaId:s,meta:t,baseId:n,localRefs:c}),this._cache.set(a.schema,a),o&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),i&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function A(e,t,n,i="error"){for(const o in e){const r=o;r in t&&this.logger[i](`${n}: option ${o}. ${e[r]}`)}}function S(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function x(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function E(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function M(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function T(){const e={...this.opts};for(const t of f)delete e[t];return e}C.ValidationError=r.default,C.MissingRefError=s.default,t.default=C;const I={log(){},warn(){},error(){}},L=/^[a-z_$][a-z0-9_$:-]*$/i;function _(e,t){const{RULES:n}=this;if((0,d.eachItem)(e,e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!L.test(e))throw new Error(`Keyword ${e} has invalid name`)}),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function N(e,t,n){var i;const o=null==t?void 0:t.post;if(n&&o)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:r}=this;let s=o?r.post:r.rules.find(({type:e})=>e===n);if(s||(s={type:n,rules:[]},r.rules.push(s)),r.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)}};t.before?P.call(this,s,a,t.before):s.rules.push(a),r.all[e]=a,null===(i=t.implements)||void 0===i||i.forEach(e=>this.addKeyword(e))}function P(e,t,n){const i=e.rules.findIndex(e=>e.keyword===n);i>=0?e.rules.splice(i,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function R(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=O(t)),e.validateSchema=this.compile(t,!0))}const $={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(e){return{anyOf:[e,$]}}},9572(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1678),o=n(7216),r=n(9547),s=n(8226),a=n(518),l=n(4588),c=n(5707),u=n(7082),h=["/properties"];t.default=function(e){return[i,o,r,s,a,t(this,l),c,t(this,u)].forEach(e=>this.addMetaSchema(e,void 0,!1)),this;function t(t,n){return e?t.$dataMetaSchema(n,h):n}}},6250(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2017);i.code='require("ajv/dist/runtime/equal").default',t.default=i},3853(e,t){"use strict";function n(e){const t=e.length;let n,i=0,o=0;for(;o<t;)i++,n=e.charCodeAt(o++),n>=55296&&n<=56319&&o<t&&(n=e.charCodeAt(o),56320==(64512&n)&&o++);return i}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(8343);i.code='require("ajv/dist/runtime/uri").default',t.default=i},3558(e,t){"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},5457(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const i=n(9029),o=n(4227),r={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:i}=t;Array.isArray(i)?s(e,i):(0,o.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function s(e,t){const{gen:n,schema:r,data:s,keyword:a,it:l}=e;l.items=!0;const c=n.const("len",i._`${s}.length`);if(!1===r)e.setParams({len:t.length}),e.pass(i._`${c} <= ${t.length}`);else if("object"==typeof r&&!(0,o.alwaysValidSchema)(l,r)){const r=n.var("valid",i._`${c} <= ${t.length}`);n.if((0,i.not)(r),()=>function(r){n.forRange("i",t.length,c,t=>{e.subschema({keyword:a,dataProp:t,dataPropType:o.Type.Num},r),l.allErrors||n.if((0,i.not)(r),()=>n.break())})}(r)),e.ok(r)}}t.validateAdditionalItems=s,t.default=r},8660(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(2023),s=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>o._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:l,errsCount:c,it:u}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:h,opts:d}=u;if(u.props=!0,"all"!==d.removeAdditional&&(0,s.alwaysValidSchema)(u,n))return;const m=(0,i.allSchemaProperties)(a.properties),p=(0,i.allSchemaProperties)(a.patternProperties);function g(e){t.code(o._`delete ${l}[${e}]`)}function f(i){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)g(i);else{if(!1===n)return e.setParams({additionalProperty:i}),e.error(),void(h||t.break());if("object"==typeof n&&!(0,s.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===d.removeAdditional?(y(i,n,!1),t.if((0,o.not)(n),()=>{e.reset(),g(i)})):(y(i,n),h||t.if((0,o.not)(n),()=>t.break()))}}}function y(t,n,i){const o={keyword:"additionalProperties",dataProp:t,dataPropType:s.Type.Str};!1===i&&Object.assign(o,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(o,n)}t.forIn("key",l,n=>{m.length||p.length?t.if(function(n){let r;if(m.length>8){const e=(0,s.schemaRefOrVal)(u,a.properties,"properties");r=(0,i.isOwnProperty)(t,e,n)}else r=m.length?(0,o.or)(...m.map(e=>o._`${n} === ${e}`)):o.nil;return p.length&&(r=(0,o.or)(r,...p.map(t=>o._`${(0,i.usePattern)(e,t)}.test(${n})`))),(0,o.not)(r)}(n),()=>f(n)):f(n)}),e.ok(o._`${c} === ${r.default.errors}`)}};t.default=a},5844(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const r=t.name("valid");n.forEach((t,n)=>{if((0,i.alwaysValidSchema)(o,t))return;const s=e.subschema({keyword:"allOf",schemaProp:n},r);e.ok(r),e.mergeEvaluated(s)})}};t.default=o},6505(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=i},2661(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?i.str`must contain at least ${e} valid item(s)`:i.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?i._`{minContains: ${e}}`:i._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:r,data:s,it:a}=e;let l,c;const{minContains:u,maxContains:h}=r;a.opts.next?(l=void 0===u?1:u,c=h):l=1;const d=t.const("len",i._`${s}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,o.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,o.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,o.alwaysValidSchema)(a,n)){let t=i._`${d} >= ${l}`;return void 0!==c&&(t=i._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const m=t.name("valid");function p(){const e=t.name("_valid"),n=t.let("count",0);g(e,()=>t.if(e,()=>function(e){t.code(i._`${e}++`),void 0===c?t.if(i._`${e} >= ${l}`,()=>t.assign(m,!0).break()):(t.if(i._`${e} > ${c}`,()=>t.assign(m,!1).break()),1===l?t.assign(m,!0):t.if(i._`${e} >= ${l}`,()=>t.assign(m,!0)))}(n)))}function g(n,i){t.forRange("i",0,d,t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:o.Type.Num,compositeRule:!0},n),i()})}void 0===c&&1===l?g(m,()=>t.if(m,()=>t.break())):0===l?(t.let(m,!0),void 0!==c&&t.if(i._`${s}.length > 0`,p)):(t.let(m,!1),p()),e.result(m,()=>e.reset())}};t.default=r},3025(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const i=n(9029),o=n(4227),r=n(5765);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const o=1===t?"property":"properties";return i.str`must have ${o} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:o}})=>i._`{property: ${e},
5
5
  missingProperty: ${o},
6
6
  depsCount: ${t},
7
- deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const i in e)"__proto__"!==i&&((Array.isArray(e[i])?t:n)[i]=e[i]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:o,it:s}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,r.propertyInData)(n,o,l,s.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(u,()=>{for(const t of c)(0,r.checkReportMissingProp)(e,t)}):(n.if(i._`${u} && (${(0,r.checkMissingProp)(e,c,a)})`),(0,r.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:i,keyword:s,it:a}=e,l=n.name("valid");for(const c in t)(0,o.alwaysValidSchema)(a,t[c])||(n.if((0,r.propertyInData)(n,i,c,a.opts.ownProperties),()=>{const t=e.subschema({keyword:s,schemaProp:c},l);e.mergeValidEvaluated(t,l)},()=>n.var(l,!0)),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=s},4845(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,i.validateSchemaDeps)(e)};t.default=o},1239(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>i.str`must match "${e.ifClause}" schema`,params:({params:e})=>i._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:r}=e;void 0===n.then&&void 0===n.else&&(0,o.checkStrictMode)(r,'"if" without "then" and "else" is ignored');const a=s(r,"then"),l=s(r,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,i.not)(u),h("else"));function h(n,o){return()=>{const r=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(r,c),o?t.assign(o,i._`${n}`):e.setParams({ifClause:n})}}e.pass(c,()=>e.error(!0))}};function s(e,t){const n=e.schema[t];return void 0!==n&&!(0,o.alwaysValidSchema)(e,n)}t.default=r},6378(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5457),o=n(5354),r=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),u=n(8660),h=n(117),d=n(5333),m=n(7923),p=n(6505),g=n(6163),f=n(5844),y=n(1239),b=n(4426);t.default=function(e=!1){const t=[m.default,p.default,g.default,f.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(o.default,s.default):t.push(i.default,r.default),t.push(a.default),t}},494(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const i=n(9029),o=n(4227),r=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,o.alwaysValidSchema)(n,t)||e.ok((0,r.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:r,parentSchema:s,data:a,keyword:l,it:c}=e;!function(e){const{opts:i,errSchemaPath:r}=c,s=n.length,a=s===e.minItems&&(s===e.maxItems||!1===e[t]);if(i.strictTuples&&!a){const e=`"${l}" is ${s}-tuple, but minItems or maxItems/${t} are not specified or different at path "${r}"`;(0,o.checkStrictMode)(c,e,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=o.mergeEvaluated.items(r,n.length,c.items));const u=r.name("valid"),h=r.const("len",i._`${a}.length`);n.forEach((t,n)=>{(0,o.alwaysValidSchema)(c,t)||(r.if(i._`${h} > ${n}`,()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u)),e.ok(u))})}t.validateTuple=a,t.default=s},3966(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:i}=e,{prefixItems:a}=n;i.items=!0,(0,o.alwaysValidSchema)(i,t)||(a?(0,s.validateAdditionalItems)(e,a):e.ok((0,r.validateArray)(e)))}};t.default=a},7923(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:o}=e;if((0,i.alwaysValidSchema)(o,n))return void e.fail();const r=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},r),e.failResult(r,()=>e.reset(),()=>e.error())},error:{message:"must NOT be valid"}};t.default=o},6163(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>i._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&r.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block(function(){a.forEach((n,r)=>{let a;(0,o.alwaysValidSchema)(s,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:r,compositeRule:!0},u),r>0&&t.if(i._`${u} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${r}]`).else(),t.if(u,()=>{t.assign(l,!0),t.assign(c,r),a&&e.mergeEvaluated(a,i.Name)})})}),e.result(l,()=>e.reset(),()=>e.error(!0))}};t.default=r},5333(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,i.allSchemaProperties)(n),d=h.filter(e=>(0,r.alwaysValidSchema)(c,n[e]));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const m=u.strictSchema&&!u.allowMatchingProperties&&l.properties,p=t.name("valid");!0===c.props||c.props instanceof o.Name||(c.props=(0,s.evaluatedPropsToName)(t,c.props));const{props:g}=c;function f(e){for(const t in m)new RegExp(e).test(t)&&(0,r.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,r=>{t.if(o._`${(0,i.usePattern)(e,n)}.test(${r})`,()=>{const i=d.includes(n);i||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:r,dataPropType:s.Type.Str},p),c.opts.unevaluated&&!0!==g?t.assign(o._`${g}[${r}]`,!0):i||c.allErrors||t.if((0,o.not)(p),()=>t.break())})})}!function(){for(const e of h)m&&f(e),c.allErrors?y(e):(t.var(p,!0),y(e),t.if(p))}()}};t.default=a},5354(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(494),o={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,i.validateTuple)(e,"items")};t.default=o},117(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),o=n(5765),r=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,o.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=r.mergeEvaluated.props(t,(0,r.toHash)(u),c.props));const h=u.filter(e=>!(0,r.alwaysValidSchema)(c,n[e]));if(0===h.length)return;const d=t.name("valid");for(const n of h)m(n)?p(n):(t.if((0,o.propertyInData)(t,l,n,c.opts.ownProperties)),p(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function m(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function p(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},2094(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>i._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e;if((0,o.alwaysValidSchema)(s,n))return;const a=t.name("valid");t.forIn("key",r,n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,i.not)(a),()=>{e.error(!0),s.allErrors||t.break()})}),e.ok(a)}};t.default=r},4426(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,i.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=o},5765(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const i=n(9029),o=n(4227),r=n(2023),s=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return i._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} === undefined`;return o?(0,i.or)(r,(0,i.not)(l(e,t,n))):r}function u(e){return e?Object.keys(e).filter(e=>"__proto__"!==e):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:o,it:r}=e;n.if(c(n,o,t,r.opts.ownProperties),()=>{e.setParams({missingProperty:i._`${t}`},!0),e.error()})},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},o,r){return(0,i.or)(...o.map(o=>(0,i.and)(c(e,t,o,n.ownProperties),i._`${r} = ${o}`)))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} !== undefined`;return o?i._`${r} && ${l(e,t,n)}`:r},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter(n=>!(0,o.alwaysValidSchema)(e,t[n]))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:o,schemaPath:s,errorPath:a},it:l},c,u,h){const d=h?i._`${e}, ${t}, ${o}${s}`:t,m=[[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,a)],[r.default.parentData,l.parentData],[r.default.parentDataProperty,l.parentDataProperty],[r.default.rootData,r.default.rootData]];l.opts.dynamicRef&&m.push([r.default.dynamicAnchors,r.default.dynamicAnchors]);const p=i._`${d}, ${n.object(...m)}`;return u!==i.nil?i._`${c}.call(${u}, ${p})`:i._`${c}(${p})`};const h=i._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const o=t.unicodeRegExp?"u":"",{regExp:r}=t.code,a=r(n,o);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===r.code?h:(0,s.useFunc)(e,r)}(${n}, ${o})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:r,it:s}=e,a=t.name("valid");if(s.allErrors){const e=t.let("valid",!0);return l(()=>t.assign(e,!1)),e}return t.var(a,!0),l(()=>t.break()),a;function l(s){const l=t.const("len",i._`${n}.length`);t.forRange("i",0,l,n=>{e.subschema({keyword:r,dataProp:n,dataPropType:o.Type.Num},a),t.if((0,i.not)(a),s)})}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some(e=>(0,o.alwaysValidSchema)(s,e))&&!s.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block(()=>n.forEach((n,o)=>{const s=e.subschema({keyword:r,schemaProp:o,compositeRule:!0},l);t.assign(a,i._`${a} || ${l}`),e.mergeValidEvaluated(s,l)||t.if((0,i.not)(a))})),e.result(a,()=>e.reset(),()=>e.error(!0))}},3463(e,t){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3463),o=n(3693),r=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,o.default];t.default=r},3693(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const i=n(4551),o=n(5765),r=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:o}=e,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:m}=o,{root:p}=l;if(("#"===n||"#/"===n)&&s===p.baseId)return function(){if(l===p)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:p});return h(e,r._`${n}.validate`,p,p.$async)}();const g=a.resolveRef.call(m,p,s,n);if(void 0===g)throw new i.default(o.opts.uriResolver,s,n);return g instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(g):function(i){const o=t.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,r.stringify)(i)}:{ref:i}),s=t.name("valid"),a=e.subschema({schema:i,dataTypes:[],schemaPath:r.nil,topSchemaRef:o,errSchemaPath:n},s);e.mergeEvaluated(a),e.ok(s)}(g)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):r._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,i){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,m=d.passContext?s.default.this:r.nil;function p(e){const t=r._`${e}.errors`;a.assign(s.default.vErrors,r._`${s.default.vErrors} === null ? ${t} : ${s.default.vErrors}.concat(${t})`),a.assign(s.default.errors,r._`${s.default.vErrors}.length`)}function g(e){var t;if(!c.opts.unevaluated)return;const i=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const t=a.var("props",r._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,r.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const t=a.var("items",r._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,r.Name)}}i?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try(()=>{a.code(r._`await ${(0,o.callValidateCode)(e,t,m)}`),g(t),u||a.assign(n,!0)},e=>{a.if(r._`!(${e} instanceof ${c.ValidationError})`,()=>a.throw(e)),p(e),u||a.assign(n,!1)}),e.ok(n)}():e.result((0,o.callValidateCode)(e,t,m),()=>g(t),()=>p(t))}t.getValidate=u,t.callRef=h,t.default=c},6653(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(7652),r=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===o.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>i._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:l,parentSchema:c,it:u}=e,{oneOf:h}=c;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!h)throw new Error("discriminator: requires oneOf keyword");const m=t.let("valid",!1),p=t.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function g(n){const o=t.name("valid"),r=e.subschema({keyword:"oneOf",schemaProp:n},o);return e.mergeEvaluated(r,i.Name),o}t.if(i._`typeof ${p} == "string"`,()=>function(){const n=function(){var e;const t={},n=o(c);let i=!0;for(let t=0;t<h.length;t++){let c=h[t];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,u.self.RULES)){const e=c.$ref;if(c=r.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),c instanceof r.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(u.opts.uriResolver,u.baseId,e)}const m=null===(e=null==c?void 0:c.properties)||void 0===e?void 0:e[d];if("object"!=typeof m)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||o(c)),l(m,t)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return t;function o({required:e}){return Array.isArray(e)&&e.includes(d)}function l(e,t){if(e.const)m(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of e.enum)m(n,t)}}function m(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${d}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(i._`${p} === ${e}`),t.assign(m,g(n[e]));t.else(),e.error(!1,{discrError:o.DiscrError.Mapping,tag:p,tagName:d}),t.endIf()}(),()=>e.error(!1,{discrError:o.DiscrError.Tag,tag:p,tagName:d})),e.ok(m)}};t.default=l},7652(e,t){"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),u=n(9857),h=[s.default,i.default,o.default,(0,r.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},6144(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(7532),a=n(9857),l=[i.default,o.default,(0,r.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},2476(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const i=n(9029),o=n(2023),r=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=i._`${o.default.dynamicAnchors}${(0,i.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:i}=e.it,{root:o,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=i.opts,h=new r.SchemaEnv({schema:n,schemaId:u,root:o,baseId:a,localRefs:l,meta:c});return r.compileSchema.call(i,h),(0,s.getValidate)(e,h)}(e);n.if(i._`!${l}`,()=>n.assign(l,c))}t.dynamicAnchor=l,t.default=a},3252(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const i=n(9029),o=n(2023),r=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:s,it:a}=e;if("#"!==t[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",i._`${o.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,i){return i?()=>n.block(()=>{(0,r.callRef)(e,t),n.let(i,!0)}):()=>(0,r.callRef)(e,t)}}t.dynamicRef=a,t.default=s},5520(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(3252),r=n(2721),s=n(3799),a=[i.default,o.default,r.default,s.default];t.default=a},2721(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(4227),r={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,i.dynamicAnchor)(e,""):(0,o.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=r},3799(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3252),o={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,i.dynamicRef)(e,e.schema)};t.default=o},4737(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match format "${e}"`,params:({schemaCode:e})=>i._`{format: ${e}}`},code(e,t){const{gen:n,data:o,$data:r,schema:s,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(r?function(){const r=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${r}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,()=>n.assign(l,i._`${s}.type || "string"`).assign(u,i._`${s}.validate`),()=>n.assign(l,i._`"string"`).assign(u,s)),e.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${u}`,function(){const e=h.$async?i._`(${s}.async ? await ${u}(${o}) : ${u}(${o}))`:i._`${u}(${o})`,n=i._`(typeof ${u} == "function" ? ${e} : ${u}.test(${o}))`;return i._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const r=d.formats[s];if(!r)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${s}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===r)return;const[a,l,m]=function(e){const t=e instanceof RegExp?(0,i.regexpCode)(e):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,o=n.scopeValue("formats",{key:s,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,o]:[e.type||"string",e.validate,i._`${o}.validate`]}(r);a===t&&e.pass(function(){if("object"==typeof r&&!(r instanceof RegExp)&&r.async){if(!h.$async)throw new Error("async format in sync schema");return i._`await ${m}(${o})`}return"function"==typeof l?i._`${m}(${o})`:i._`${m}.test(${o})`}())}())}};t.default=o},7532(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=[n(4737).default];t.default=i},9857(e,t){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1846),o=n(4845),r=n(2626),s=[i.default,o.default,r.default];t.default=s},3265(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(392),o=n(3445),r=[i.default,o.default];t.default=r},3445(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e,a=s.items||0;if(!0===a)return;const l=t.const("len",i._`${r}.length`);if(!1===n)e.setParams({len:a}),e.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,o.alwaysValidSchema)(s,n)){const n=t.var("valid",i._`${l} <= ${a}`);t.if((0,i.not)(n),()=>function(n,r){t.forRange("i",r,l,r=>{e.subschema({keyword:"unevaluatedItems",dataProp:r,dataPropType:o.Type.Num},n),s.allErrors||t.if((0,i.not)(n),()=>t.break())})}(n,a)),e.ok(n)}s.items=!0}};t.default=r},392(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>i._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:s,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(r){if(!1===n)return e.setParams({unevaluatedProperty:r}),e.error(),void(c||t.break());if(!(0,o.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:r,dataPropType:o.Type.Str},n),c||t.if((0,i.not)(n),()=>t.break())}}u instanceof i.Name?t.if(i._`${u} !== true`,()=>t.forIn("key",s,e=>t.if(function(e,t){return i._`!${e} || !${e}[${t}]`}(u,e),()=>h(e)))):!0!==u&&t.forIn("key",s,e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const o in e)!0===e[o]&&n.push(i._`${t} !== ${o}`);return(0,i.and)(...n)}(u,e),()=>h(e))),l.props=!0,e.ok(i._`${a} === ${r.default.errors}`)}};t.default=s},7935(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>i._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:s,schemaCode:a,schema:l}=e;s||l&&"object"==typeof l?e.fail$data(i._`!${(0,o.useFunc)(t,r.default)}(${n}, ${a})`):e.fail(i._`${l} !== ${n}`)}};t.default=s},1846(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:e=>(0,i.validatePropertyDeps)(e)};t.default=o},8643(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>i._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:s,schema:a,schemaCode:l,it:c}=e;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,o.useFunc)(t,r.default);let m;if(u||s)m=t.let("valid"),e.block$data(m,function(){t.assign(m,!1),t.forOf("v",l,e=>t.if(i._`${d()}(${n}, ${e})`,()=>t.assign(m,!0).break()))});else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);m=(0,i.or)(...a.map((t,o)=>function(e,t){const o=a[t];return"object"==typeof o&&null!==o?i._`${d()}(${n}, ${e}[${t}])`:i._`${n} === ${o}`}(e,o)))}e.pass(m)}};t.default=s},7060(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5882),o=n(3439),r=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),u=n(617),h=n(7935),d=n(8643),m=[i.default,o.default,r.default,s.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=m},2626(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,i.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=o},1163(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxItems"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`${n}.length ${r} ${o}`)}};t.default=o},7307(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:s,it:a}=e,l="maxLength"===t?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,o.useFunc)(e.gen,r.default)}(${n})`;e.fail$data(i._`${c} ${l} ${s}`)}};t.default=s},5882(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=i.operators,r={maximum:{okStr:"<=",ok:o.LTE,fail:o.GT},minimum:{okStr:">=",ok:o.GTE,fail:o.LT},exclusiveMaximum:{okStr:"<",ok:o.LT,fail:o.GTE},exclusiveMinimum:{okStr:">",ok:o.GT,fail:o.LTE}},s={message:({keyword:e,schemaCode:t})=>i.str`must be ${r[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>i._`{comparison: ${r[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(r),type:"number",schemaType:"number",$data:!0,error:s,code(e){const{keyword:t,data:n,schemaCode:o}=e;e.fail$data(i._`${n} ${r[t].fail} ${o} || isNaN(${n})`)}};t.default=a},4486(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxProperties"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`Object.keys(${n}).length ${r} ${o}`)}};t.default=o},3439(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>i.str`must be multiple of ${e}`,params:({schemaCode:e})=>i._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:o,it:r}=e,s=r.opts.multipleOfPrecision,a=t.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;e.fail$data(i._`(${o} === 0 || (${a} = ${n}/${o}, ${l}))`)}};t.default=o},422(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>o.str`must match pattern "${e}"`,params:({schemaCode:e})=>o._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:r,schemaCode:s,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?o._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(e,r);e.fail$data(o._`!${c}.test(${t})`)}};t.default=r},4003(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>o.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>o._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:s,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(o.nil,d);else for(const t of n)(0,i.checkReportMissingProp)(e,t)}():function(){const r=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,()=>function(n,r){e.setParams({missingProperty:n}),t.forOf(n,s,()=>{t.assign(r,(0,i.propertyInData)(t,a,n,u.ownProperties)),t.if((0,o.not)(r),()=>{e.error(),t.break()})},o.nil)}(r,n)),e.ok(n)}else t.if((0,i.checkMissingProp)(e,n,r)),(0,i.reportMissingProp)(e,r),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:i}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!i.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,r.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",s,n=>{e.setParams({missingProperty:n}),t.if((0,i.noPropertyInData)(t,a,n,u.ownProperties),()=>e.error())})}}};t.default=s},617(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(208),o=n(9029),r=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>o.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>o._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),m=c.items?(0,i.getSchemaTypes)(c.items):[];function p(r,s){const a=t.name("item"),l=(0,i.checkDataTypes)(m,a,h.opts.strictNumbers,i.DataType.Wrong),c=t.const("indices",o._`{}`);t.for(o._`;${r}--;`,()=>{t.let(a,o._`${n}[${r}]`),t.if(l,o._`continue`),m.length>1&&t.if(o._`typeof ${a} == "string"`,o._`${a} += "_"`),t.if(o._`typeof ${c}[${a}] == "number"`,()=>{t.assign(s,o._`${c}[${a}]`),e.error(),t.assign(d,!1).break()}).code(o._`${c}[${a}] = ${r}`)})}function g(i,a){const l=(0,r.useFunc)(t,s.default),c=t.name("outer");t.label(c).for(o._`;${i}--;`,()=>t.for(o._`${a} = ${i}; ${a}--;`,()=>t.if(o._`${l}(${n}[${i}], ${n}[${a}])`,()=>{e.error(),t.assign(d,!1).break(c)})))}e.block$data(d,function(){const i=t.let("i",o._`${n}.length`),r=t.let("j");e.setParams({i,j:r}),t.assign(d,!0),t.if(o._`${i} > 1`,()=>(m.length>0&&!m.some(e=>"object"===e||"array"===e)?p:g)(i,r))},o._`${u} === false`),e.ok(d)}};t.default=a},5488(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=s},6520(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-collections-view {\n padding: 16px;\n overflow-y: auto;\n height: 100%;\n}\n\n.monomer-collections-grid {\n display: flex;\n flex-wrap: wrap;\n gap: 16px;\n align-content: flex-start;\n}\n\n.monomer-collection-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 1px solid var(--grey-2);\n border-radius: 8px;\n background: var(--white);\n display: flex;\n flex-direction: column;\n overflow: hidden;\n transition: box-shadow 0.2s ease;\n}\n\n.monomer-collection-card:hover {\n box-shadow: 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-selected {\n border-color: #ff8c00;\n box-shadow: 0 0 0 1px #ff8c00;\n}\n\n.monomer-collection-card-selected:hover {\n box-shadow: 0 0 0 1px #ff8c00, 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-header {\n padding: 12px 14px 8px 14px;\n border-bottom: 1px solid var(--grey-2);\n flex-shrink: 0;\n}\n\n.monomer-collection-card-title {\n font-size: 14px;\n font-weight: 600;\n color: var(--grey-6);\n margin: 0;\n overflow: hidden;\n text-overflow: ellipsis;\n white-space: nowrap;\n}\n\n.monomer-collection-card-description {\n font-size: 11px;\n color: var(--grey-4);\n margin: 4px 0 0 0;\n overflow: hidden;\n text-overflow: ellipsis;\n display: -webkit-box;\n -webkit-line-clamp: 2;\n -webkit-box-orient: vertical;\n}\n\n.monomer-collection-card-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 3px;\n margin: 4px 0 0 0;\n}\n\n.monomer-collection-card-tag {\n display: inline-block;\n padding: 1px 6px;\n border-radius: 3px;\n background: #e8f0fe;\n border: 1px solid var(--blue-2, #aecbfa);\n font-size: 10px;\n color: var(--blue-3, #4285f4);\n}\n\n.monomer-collection-card-meta {\n font-size: 10px;\n color: var(--grey-3);\n margin: 4px 0 0 0;\n}\n\n.monomer-collections-search {\n margin-bottom: 12px;\n}\n\n.monomer-collections-search input {\n width: 100%;\n max-width: 400px;\n}\n\n.monomer-collection-card-body {\n flex: 1;\n overflow-y: auto;\n padding: 10px 14px;\n min-height: 0;\n}\n\n.monomer-collection-card-actions {\n padding: 0px 14px;\n border-top: 1px solid var(--grey-2);\n display: flex;\n gap: 8px;\n justify-content: flex-end;\n flex-shrink: 0;\n}\n\n.monomer-collection-card-actions .ui-btn {\n font-size: 11px;\n padding: 2px 10px;\n margin: 0;\n}\n\n.monomer-collection-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 4px;\n}\n\n.monomer-collection-tag {\n display: inline-block;\n padding: 2px 8px;\n border-radius: 4px;\n background: var(--grey-1);\n border: 1px solid var(--grey-2);\n font-size: 11px;\n color: var(--grey-5);\n cursor: pointer;\n transition: background 0.15s ease;\n}\n\n.monomer-collection-tag:hover {\n background: var(--blue-1, #e8f0fe);\n border-color: var(--blue-2, #aecbfa);\n}\n\n.monomer-collection-add-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 2px dashed var(--grey-3);\n border-radius: 8px;\n display: flex;\n align-items: center;\n justify-content: center;\n cursor: pointer;\n transition: border-color 0.2s ease, background 0.2s ease;\n}\n\n.monomer-collection-add-card:hover {\n border-color: var(--blue-2, #aecbfa);\n background: var(--blue-1, #e8f0fe);\n}\n\n.monomer-collection-add-card-content {\n text-align: center;\n color: var(--grey-4);\n}\n\n.monomer-collection-add-card-content .grok-icon {\n font-size: 32px;\n margin-bottom: 8px;\n}\n\n.monomer-collection-add-card-content span {\n display: block;\n font-size: 13px;\n}\n\n.monomer-collections-load-more {\n width: 100%;\n display: flex;\n justify-content: center;\n padding: 16px 0;\n}\n\n.monomer-collections-load-more .ui-btn {\n min-width: 200px;\n}\n\n.monomer-collection-empty-state {\n width: 100%;\n text-align: center;\n padding: 60px 20px;\n color: var(--grey-4);\n font-size: 14px;\n}\n","",{version:3,sources:["webpack://./css/monomer-collections.css"],names:[],mappings:"AAAA;EACE,aAAa;EACb,gBAAgB;EAChB,YAAY;AACd;;AAEA;EACE,aAAa;EACb,eAAe;EACf,SAAS;EACT,yBAAyB;AAC3B;;AAEA;EACE,UAAU;EACV,gBAAgB;EAChB,aAAa;EACb,+BAA+B;EAC/B,kBAAkB;EAClB,wBAAwB;EACxB,aAAa;EACb,sBAAsB;EACtB,gBAAgB;EAChB,gCAAgC;AAClC;;AAEA;EACE,0CAA0C;AAC5C;;AAEA;EACE,qBAAqB;EACrB,6BAA6B;AAC/B;;AAEA;EACE,6DAA6D;AAC/D;;AAEA;EACE,2BAA2B;EAC3B,sCAAsC;EACtC,cAAc;AAChB;;AAEA;EACE,eAAe;EACf,gBAAgB;EAChB,oBAAoB;EACpB,SAAS;EACT,gBAAgB;EAChB,uBAAuB;EACvB,mBAAmB;AACrB;;AAEA;EACE,eAAe;EACf,oBAAoB;EACpB,iBAAiB;EACjB,gBAAgB;EAChB,uBAAuB;EACvB,oBAAoB;EACpB,qBAAqB;EACrB,4BAA4B;AAC9B;;AAEA;EACE,aAAa;EACb,eAAe;EACf,QAAQ;EACR,iBAAiB;AACnB;;AAEA;EACE,qBAAqB;EACrB,gBAAgB;EAChB,kBAAkB;EAClB,mBAAmB;EACnB,wCAAwC;EACxC,eAAe;EACf,6BAA6B;AAC/B;;AAEA;EACE,eAAe;EACf,oBAAoB;EACpB,iBAAiB;AACnB;;AAEA;EACE,mBAAmB;AACrB;;AAEA;EACE,WAAW;EACX,gBAAgB;AAClB;;AAEA;EACE,OAAO;EACP,gBAAgB;EAChB,kBAAkB;EAClB,aAAa;AACf;;AAEA;EACE,iBAAiB;EACjB,mCAAmC;EACnC,aAAa;EACb,QAAQ;EACR,yBAAyB;EACzB,cAAc;AAChB;;AAEA;EACE,eAAe;EACf,iBAAiB;EACjB,SAAS;AACX;;AAEA;EACE,aAAa;EACb,eAAe;EACf,QAAQ;AACV;;AAEA;EACE,qBAAqB;EACrB,gBAAgB;EAChB,kBAAkB;EAClB,yBAAyB;EACzB,+BAA+B;EAC/B,eAAe;EACf,oBAAoB;EACpB,eAAe;EACf,iCAAiC;AACnC;;AAEA;EACE,kCAAkC;EAClC,oCAAoC;AACtC;;AAEA;EACE,UAAU;EACV,gBAAgB;EAChB,aAAa;EACb,gCAAgC;EAChC,kBAAkB;EAClB,aAAa;EACb,mBAAmB;EACnB,uBAAuB;EACvB,eAAe;EACf,wDAAwD;AAC1D;;AAEA;EACE,oCAAoC;EACpC,kCAAkC;AACpC;;AAEA;EACE,kBAAkB;EAClB,oBAAoB;AACtB;;AAEA;EACE,eAAe;EACf,kBAAkB;AACpB;;AAEA;EACE,cAAc;EACd,eAAe;AACjB;;AAEA;EACE,WAAW;EACX,aAAa;EACb,uBAAuB;EACvB,eAAe;AACjB;;AAEA;EACE,gBAAgB;AAClB;;AAEA;EACE,WAAW;EACX,kBAAkB;EAClB,kBAAkB;EAClB,oBAAoB;EACpB,eAAe;AACjB",sourcesContent:[".monomer-collections-view {\n padding: 16px;\n overflow-y: auto;\n height: 100%;\n}\n\n.monomer-collections-grid {\n display: flex;\n flex-wrap: wrap;\n gap: 16px;\n align-content: flex-start;\n}\n\n.monomer-collection-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 1px solid var(--grey-2);\n border-radius: 8px;\n background: var(--white);\n display: flex;\n flex-direction: column;\n overflow: hidden;\n transition: box-shadow 0.2s ease;\n}\n\n.monomer-collection-card:hover {\n box-shadow: 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-selected {\n border-color: #ff8c00;\n box-shadow: 0 0 0 1px #ff8c00;\n}\n\n.monomer-collection-card-selected:hover {\n box-shadow: 0 0 0 1px #ff8c00, 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-header {\n padding: 12px 14px 8px 14px;\n border-bottom: 1px solid var(--grey-2);\n flex-shrink: 0;\n}\n\n.monomer-collection-card-title {\n font-size: 14px;\n font-weight: 600;\n color: var(--grey-6);\n margin: 0;\n overflow: hidden;\n text-overflow: ellipsis;\n white-space: nowrap;\n}\n\n.monomer-collection-card-description {\n font-size: 11px;\n color: var(--grey-4);\n margin: 4px 0 0 0;\n overflow: hidden;\n text-overflow: ellipsis;\n display: -webkit-box;\n -webkit-line-clamp: 2;\n -webkit-box-orient: vertical;\n}\n\n.monomer-collection-card-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 3px;\n margin: 4px 0 0 0;\n}\n\n.monomer-collection-card-tag {\n display: inline-block;\n padding: 1px 6px;\n border-radius: 3px;\n background: #e8f0fe;\n border: 1px solid var(--blue-2, #aecbfa);\n font-size: 10px;\n color: var(--blue-3, #4285f4);\n}\n\n.monomer-collection-card-meta {\n font-size: 10px;\n color: var(--grey-3);\n margin: 4px 0 0 0;\n}\n\n.monomer-collections-search {\n margin-bottom: 12px;\n}\n\n.monomer-collections-search input {\n width: 100%;\n max-width: 400px;\n}\n\n.monomer-collection-card-body {\n flex: 1;\n overflow-y: auto;\n padding: 10px 14px;\n min-height: 0;\n}\n\n.monomer-collection-card-actions {\n padding: 0px 14px;\n border-top: 1px solid var(--grey-2);\n display: flex;\n gap: 8px;\n justify-content: flex-end;\n flex-shrink: 0;\n}\n\n.monomer-collection-card-actions .ui-btn {\n font-size: 11px;\n padding: 2px 10px;\n margin: 0;\n}\n\n.monomer-collection-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 4px;\n}\n\n.monomer-collection-tag {\n display: inline-block;\n padding: 2px 8px;\n border-radius: 4px;\n background: var(--grey-1);\n border: 1px solid var(--grey-2);\n font-size: 11px;\n color: var(--grey-5);\n cursor: pointer;\n transition: background 0.15s ease;\n}\n\n.monomer-collection-tag:hover {\n background: var(--blue-1, #e8f0fe);\n border-color: var(--blue-2, #aecbfa);\n}\n\n.monomer-collection-add-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 2px dashed var(--grey-3);\n border-radius: 8px;\n display: flex;\n align-items: center;\n justify-content: center;\n cursor: pointer;\n transition: border-color 0.2s ease, background 0.2s ease;\n}\n\n.monomer-collection-add-card:hover {\n border-color: var(--blue-2, #aecbfa);\n background: var(--blue-1, #e8f0fe);\n}\n\n.monomer-collection-add-card-content {\n text-align: center;\n color: var(--grey-4);\n}\n\n.monomer-collection-add-card-content .grok-icon {\n font-size: 32px;\n margin-bottom: 8px;\n}\n\n.monomer-collection-add-card-content span {\n display: block;\n font-size: 13px;\n}\n\n.monomer-collections-load-more {\n width: 100%;\n display: flex;\n justify-content: center;\n padding: 16px 0;\n}\n\n.monomer-collections-load-more .ui-btn {\n min-width: 200px;\n}\n\n.monomer-collection-empty-state {\n width: 100%;\n text-align: center;\n padding: 60px 20px;\n color: var(--grey-4);\n font-size: 14px;\n}\n"],sourceRoot:""}]);const a=s},857(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".scatter_plot_link {\n right: 10px;\n}\n\n.cliffs_div {\n flex-grow: initial!important;\n justify-content: flex-end;\n flex-wrap: wrap;\n}\n\n.cliffs_grid {\n margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n right: 10px;\n}\n\n.cliffs_div {\n flex-grow: initial!important;\n justify-content: flex-end;\n flex-wrap: wrap;\n}\n\n.cliffs_grid {\n margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n min-width: 220px;\n width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n min-width: 220px;\n width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314(e){"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map(function(t){var n="",i=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),i&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),i&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n}).join("")},t.i=function(e,n,i,o,r){"string"==typeof e&&(e=[[null,e,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);i&&s[u[0]]||(void 0!==r&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=r),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),o&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=o):u[4]="".concat(o)),t.push(u))}},t}},1354(e){"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),o="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),r="/*# ".concat(o," */");return[t].concat([r]).join("\n")}return[t].join("\n")}},2017(e){"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var i,o,r;if(Array.isArray(t)){if((i=t.length)!=n.length)return!1;for(o=i;0!==o--;)if(!e(t[o],n[o]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((i=(r=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(o=i;0!==o--;)if(!Object.prototype.hasOwnProperty.call(n,r[o]))return!1;for(o=i;0!==o--;){var s=r[o];if(!e(t[s],n[s]))return!1}return!0}return t!=t&&n!=n}},9982(e,t,n){var i;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,i,o,r){for(var s,a,l,c,u,h,d,m,p,g,f,y,b;r>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],m=n[7],g=0;g<16;g++)f=o+4*g,e[g]=(255&i[f])<<24|(255&i[f+1])<<16|(255&i[f+2])<<8|255&i[f+3];for(g=16;g<64;g++)y=((p=e[g-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,b=((p=e[g-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,e[g]=(y+e[g-7]|0)+(b+e[g-16]|0);for(g=0;g<64;g++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(m+(t[g]+e[g]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,m=d,d=h,h=u,u=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=m,o+=64,r-=64}return o}var i=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[i++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(i=n(this.temp,this.state,e,i,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[i++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,i=this.bufferLength,o=t/536870912|0,r=t<<3,s=t%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=o>>>24&255,this.buffer[s-7]=o>>>16&255,this.buffer[s-6]=o>>>8&255,this.buffer[s-5]=o>>>0&255,this.buffer[s-4]=r>>>24&255,this.buffer[s-3]=r>>>16&255,this.buffer[s-2]=r>>>8&255,this.buffer[s-1]=r>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=i;var o=function(){function e(e){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new i).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function r(e){var t=(new i).update(e),n=t.digest();return t.clean(),n}function s(e,t){var n=new o(e).update(t),i=n.digest();return n.clean(),i}function a(e,t,n,i){var o=i[0];if(0===o)throw new Error("hkdf: cannot expand more");t.reset(),o>1&&t.update(e),n&&t.update(n),t.update(i),t.finish(e),i[0]++}e.HMAC=o,e.hash=r,e.default=r,e.hmac=s;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,i){void 0===t&&(t=l),void 0===i&&(i=32);for(var r=new Uint8Array([1]),c=s(t,e),u=new o(c),h=new Uint8Array(u.digestLength),d=h.length,m=new Uint8Array(i),p=0;p<i;p++)d===h.length&&(a(h,u,n,r),d=0),m[p]=h[d++];return u.clean(),h.fill(0),r.fill(0),m},e.pbkdf2=function(e,t,n,i){for(var r=new o(e),s=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),u=new Uint8Array(i),h=0;h*s<i;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,r.reset(),r.update(t),r.update(a),r.finish(c);for(var m=0;m<s;m++)l[m]=c[m];for(m=2;m<=n;m++){r.reset(),r.update(c).finish(c);for(var p=0;p<s;p++)l[p]^=c[p]}for(m=0;m<s&&h*s+m<i;m++)u[h*s+m]=l[m]}for(h=0;h<s;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return r.clean(),u}}(t);var o=t.default;for(var r in t)o[r]=t[r];"object"==typeof e.exports?e.exports=o:void 0===(i=function(){return o}.call(t,n,t,e))||(e.exports=i)}()},2787(e,t,n){"use strict";n.d(t,{I:()=>o});const i=new Uint32Array(65536),o=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,o=t.length,r=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[e.charCodeAt(c)]|=1<<c;for(c=0;c<o;c++){let e=i[t.charCodeAt(c)];const n=e|a;e|=(e&s)+s^s,a|=~(e|s),s&=e,a&r&&l++,s&r&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,o=e.length,r=[],s=[],a=Math.ceil(n/32),l=Math.ceil(o/32);for(let e=0;e<a;e++)s[e]=-1,r[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,o)+u;for(let t=u;t<h;t++)i[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],o=s[e/32|0]>>>e&1,c=r[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),m=l&h;d>>>31^o&&(s[e/32|0]^=1<<e),m>>>31^c&&(r[e/32|0]^=1<<e),d=d<<1|o,m=m<<1|c,l=m|~(u|d),a=d&u}for(let t=u;t<h;t++)i[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,m=Math.min(32,o-d)+d;for(let t=d;t<m;t++)i[e.charCodeAt(t)]|=1<<t;let p=o;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],a=s[e/32|0]>>>e&1,l=r[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let m=u|~(d|h),g=h&d;p+=m>>>o-1&1,p-=g>>>o-1&1,m>>>31^a&&(s[e/32|0]^=1<<e),g>>>31^l&&(r[e/32|0]^=1<<e),m=m<<1|a,g=g<<1|l,h=g|~(c|m),u=m&c}for(let t=d;t<m;t++)i[e.charCodeAt(t)]=0;return p})(e,t)}},9937(e){e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782(e,t){t.assign=function(e){e=e||{};var t,n,i,o=Array.prototype.slice.call(arguments).slice(1);for(t=0,i=o.length;t<i;t++)if(o[t])for(n in o[t])e[n]=o[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,i=e.order,o=e.size,r={},s=new Float32Array(10*i),a=new Float32Array(3*o);return n=0,e.forEachNode(function(e,t){r[e]=n,s[n]=t.x,s[n+1]=t.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=t.size||1,s[n+9]=t.fixed?1:0,n+=10}),n=0,e.forEachEdge(function(e,i,o,l,c,u,h){var d=r[o],m=r[l],p=t(e,i,o,l,c,u,h);s[d+6]+=p,s[m+6]+=p,a[n]=d,a[n+1]=m,a[n+2]=p,n+=3}),{nodes:s,edges:a}},t.assignLayoutChanges=function(e,t,n){var i=0;e.updateEachNodeAttributes(function(e,o){return o.x=t[i],o.y=t[i+1],i+=10,n?n(e,o):o})},t.readGraphPositions=function(e,t){var n=0;e.forEachNode(function(e,i){t[n]=i.x,t[n+1]=i.y,n+=10})},t.collectLayoutChanges=function(e,t,n){for(var i=e.nodes(),o={},r=0,s=0,a=t.length;r<a;r+=10){if(n){var l=Object.assign({},e.getNodeAttributes(i[s]));l.x=t[r],l.y=t[r+1],l=n(i[s],l),o[i[s]]={x:l.x,y:l.y}}else o[i[s]]={x:t[r],y:t[r+1]};s++}return o},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),i=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),o=new Worker(i);return t.revokeObjectURL(i),o}},8903(e,t,n){var i=n(1736),o=n(8153).Fd,r=n(2561),s=n(1782),a=n(9937);function l(e,t,n){if(!i(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=o("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,h=s.assign({},a,n.settings),d=s.validateSettings(h);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var m,p=s.graphToByteArrays(t,c);for(m=0;m<l;m++)r(h,p.nodes,p.edges);if(!e)return s.collectLayoutChanges(t,p.nodes);s.assignLayoutChanges(t,p.nodes,u)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=c},2561(e){var t=10;e.exports=function(e,n,i){var o,r,s,a,l,c,u,h,d,m,p,g,f,y,b,v,w,C,A,S,x,E,M,T=n.length,I=i.length,L=e.adjustSizes,_=e.barnesHutTheta*e.barnesHutTheta,N=[];for(s=0;s<T;s+=t)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(e.outboundAttractionDistribution){for(p=0,s=0;s<T;s+=t)p+=n[s+6];p/=T/t}if(e.barnesHutOptimize){var P,R,$,O=1/0,k=-1/0,H=1/0,B=-1/0;for(s=0;s<T;s+=t)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),H=Math.min(H,n[s+1]),B=Math.max(B,n[s+1]);var F=k-O,D=B-H;for(F>D?B=(H-=(F-D)/2)+F:k=(O-=(D-F)/2)+D,N[0]=-1,N[1]=(O+k)/2,N[2]=(H+B)/2,N[3]=Math.max(k-O,B-H),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,o=1,s=0;s<T;s+=t)for(r=0,$=3;;){if(!(N[r+5]>=0)){if(N[r+0]<0){N[r+0]=s;break}if(N[r+5]=9*o,h=N[r+3]/2,N[(d=N[r+5])+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=N[r+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,o+=4,P=n[N[r+0]+0]<N[r+1]?n[N[r+0]+1]<N[r+2]?N[r+5]:N[r+5]+9:n[N[r+0]+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+6]=n[N[r+0]+6],N[r+7]=n[N[r+0]+0],N[r+8]=n[N[r+0]+1],N[P+0]=N[r+0],N[r+0]=-1,P===(R=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27)){if($--){r=P;continue}$=3;break}N[R+0]=s;break}P=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+7]=(N[r+7]*N[r+6]+n[s+0]*n[s+6])/(N[r+6]+n[s+6]),N[r+8]=(N[r+8]*N[r+6]+n[s+1]*n[s+6])/(N[r+6]+n[s+6]),N[r+6]+=n[s+6],r=P}}if(e.barnesHutOptimize){for(g=e.scalingRatio,s=0;s<T;s+=t)for(r=0;;)if(N[r+5]>=0){if(v=Math.pow(n[s+0]-N[r+7],2)+Math.pow(n[s+1]-N[r+8],2),4*(m=N[r+3])*m/v<_){if(f=n[s+0]-N[r+7],y=n[s+1]-N[r+8],!0===L?v>0?(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*N[r+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w),(r=N[r+4])<0)break;continue}r=N[r+5]}else if((c=N[r+0])>=0&&c!==s&&(v=(f=n[s+0]-n[c+0])*f+(y=n[s+1]-n[c+1])*y,!0===L?v>0?(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w)),(r=N[r+4])<0)break}else for(g=e.scalingRatio,a=0;a<T;a+=t)for(l=0;l<a;l+=t)f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===L?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8])>0?(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):v<0&&(w=100*g*n[a+6]*n[l+6],n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):(v=Math.sqrt(f*f+y*y))>0&&(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,g=e.scalingRatio,s=0;s<T;s+=t)w=0,f=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=g*n[s+6]*d):v>0&&(w=g*n[s+6]*d/v),n[s+2]-=f*w,n[s+3]-=y*w;for(g=1*(e.outboundAttractionDistribution?p:1),u=0;u<I;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===L?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-g*b/n[a+6]):v>0&&(w=-g*b)):(v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-g*b/n[a+6]):(v=1,w=-g*b)),v>0&&(n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);if(!0===L)for(s=0;s<T;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=M);else for(s=0;s<T;s+=t)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=M);return{}}},8153(e,t){function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},i=function(e){return void 0===e?t:e};"function"==typeof t&&(i=t);var o=function(t){return i(t[e])},r=function(){return i(void 0)};return"string"==typeof e?(n.fromAttributes=o,n.fromGraph=function(e,t){return o(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return o(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var o=t.extremities(n);return i(e(n,t.getEdgeAttributes(n),o[0],o[1],t.getNodeAttributes(o[0]),t.getNodeAttributes(o[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,o,r,s,a,l){return i(e(t,n,o,r,s,a,l))},n.fromPartialEntry=function(t,n,o,r){return i(e(t,n,o,r))},n.fromMinimalEntry=function(t,n){return i(e(t,n))}):(n.fromAttributes=r,n.fromGraph=r,n.fromEntry=r,n.fromMinimalEntry=r),n}(e,n)}},1736(e){e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,i(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function i(e,t){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},i(e,t)}function o(e,t,n){return o=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],function(){})),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var o=[null];o.push.apply(o,t);var r=new(Function.bind.apply(e,o));return n&&i(r,n.prototype),r},o.apply(null,arguments)}function r(e){var t="function"==typeof Map?new Map:void 0;return r=function(e){if(null===e||(r=e,-1===Function.toString.call(r).indexOf("[native code]")))return e;var r;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,s)}function s(){return o(e,arguments,n(this).constructor)}return s.prototype=Object.create(e.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,e)},r(e)}function s(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var i in arguments[t])e[i]=arguments[t][i];return e};function l(e,t,n,i){var o=e._nodes.get(t),r=null;return o?r="mixed"===i?o.out&&o.out[n]||o.undirected&&o.undirected[n]:"directed"===i?o.out&&o.out[n]:o.undirected&&o.undirected[n]:r}function c(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function h(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(e,t,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(e,t,i)}function m(e){return!(!c(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var p,g={exports:{}},f="object"==typeof Reflect?Reflect:null,y=f&&"function"==typeof f.apply?f.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};p=f&&"function"==typeof f.ownKeys?f.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var b=Number.isNaN||function(e){return e!=e};function v(){v.init.call(this)}g.exports=v,g.exports.once=function(e,t){return new Promise(function(n,i){function o(n){e.removeListener(t,r),i(n)}function r(){"function"==typeof e.removeListener&&e.removeListener("error",o),n([].slice.call(arguments))}L(e,t,r,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&L(e,"error",t,{once:!0})}(e,o)})},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function A(e){return void 0===e._maxListeners?v.defaultMaxListeners:e._maxListeners}function S(e,t,n,i){var o,r,s,a;if(C(n),void 0===(r=e._events)?(r=e._events=Object.create(null),e._eventsCount=0):(void 0!==r.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),r=e._events),s=r[t]),void 0===s)s=r[t]=n,++e._eventsCount;else if("function"==typeof s?s=r[t]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(o=A(e))>0&&s.length>o&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=e,l.type=t,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return e}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(e,t,n){var i={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},o=x.bind(i);return o.listener=n,i.wrapFn=o,o}function M(e,t,n){var i=e._events;if(void 0===i)return[];var o=i[t];return void 0===o?[]:"function"==typeof o?n?[o.listener||o]:[o]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(o):I(o,o.length)}function T(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(e,t){for(var n=new Array(t),i=0;i<t;++i)n[i]=e[i];return n}function L(e,t,n,i){if("function"==typeof e.on)i.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,function o(r){i.once&&e.removeEventListener(t,o),n(r)})}}function _(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");w=e}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var i="error"===e,o=this._events;if(void 0!==o)i=i&&void 0===o.error;else if(!i)return!1;if(i){var r;if(t.length>0&&(r=t[0]),r instanceof Error)throw r;var s=new Error("Unhandled error."+(r?" ("+r.message+")":""));throw s.context=r,s}var a=o[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,t)}return!0},v.prototype.addListener=function(e,t){return S(this,e,t,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(e,t){return S(this,e,t,!0)},v.prototype.once=function(e,t){return C(t),this.on(e,E(this,e,t)),this},v.prototype.prependOnceListener=function(e,t){return C(t),this.prependListener(e,E(this,e,t)),this},v.prototype.removeListener=function(e,t){var n,i,o,r,s;if(C(t),void 0===(i=this._events))return this;if(void 0===(n=i[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete i[e],i.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(o=-1,r=n.length-1;r>=0;r--)if(n[r]===t||n[r].listener===t){s=n[r].listener,o=r;break}if(o<0)return this;0===o?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,o),1===n.length&&(i[e]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",e,s||t)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(e){var t,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var o,r=Object.keys(n);for(i=0;i<r.length;++i)"removeListener"!==(o=r[i])&&this.removeAllListeners(o);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(i=t.length-1;i>=0;i--)this.removeListener(e,t[i]);return this},v.prototype.listeners=function(e){return M(this,e,!0)},v.prototype.rawListeners=function(e){return M(this,e,!1)},v.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):T.call(e,t)},v.prototype.listenerCount=T,v.prototype.eventNames=function(){return this._eventsCount>0?p(this._events):[]},"undefined"!=typeof Symbol&&(_.prototype[Symbol.iterator]=function(){return this}),_.of=function(){var e=arguments,t=e.length,n=0;return new _(function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}})},_.empty=function(){return new _(function(){return{done:!0}})},_.fromSequence=function(e){var t=0,n=e.length;return new _(function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}})},_.is=function(e){return e instanceof _||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=_,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var R=N,$=P,O=$.ARRAY_BUFFER_SUPPORT,k=$.SYMBOL_SUPPORT,H=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?R.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},B=H,F=function(e,t){for(var n,i=arguments.length>1?t:1/0,o=i!==1/0?new Array(i):[],r=0,s=B(e);;){if(r===i)return o;if((n=s.next()).done)return r!==t&&(o.length=r),o;o[r++]=n.value}},D=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(r(Error)),G=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D),V=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D),q=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D);function j(e,t){this.key=e,this.attributes=t,this.clear()}function U(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function z(e,t,n,i,o){this.key=t,this.attributes=o,this.undirected=e,this.source=n,this.target=i}function Y(e,t,n,i,o,r,s){var a,l,c,u;if(i=""+i,0===n){if(!(a=e._nodes.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" node in the graph.'));c=o,u=r}else if(3===n){if(o=""+o,!(l=e._edges.get(o)))throw new V("Graph.".concat(t,': could not find the "').concat(o,'" edge in the graph.'));var h=l.source.key,d=l.target.key;if(i===h)a=l.target;else{if(i!==d)throw new V("Graph.".concat(t,': the "').concat(i,'" node is not attached to the "').concat(o,'" edge (').concat(h,", ").concat(d,")."));a=l.source}c=r,u=s}else{if(!(l=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=o,u=r}return[a,c,u]}j.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},W.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,i=this.target.key;this.source[e][i]=this,this.undirected&&n===i||(this.target[t][n]=this)},z.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,i=this.target.key;this.undirected&&(e=t="undirected");var o=this.source[e],r=o[i];if(void 0===r)return o[i]=this,void(this.undirected&&n===i||(this.target[t][n]=this));r.previous=this,this.next=r,o[i]=this,this.target[t][n]=this},z.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][t],delete this.target[i][e]},z.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[i][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[i][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){return Y(this,t,n,e,i)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new G("Graph.".concat(t,": updater should be a function."));var u=a.attributes,h=c(u[l]);return u[l]=h,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if(!c(a))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],l=r[1];if(!c(l))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if("function"!=typeof a)throw new G("Graph.".concat(t,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes[i]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,r=""+arguments[1];if(!(i=l(this,o,r,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(r,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]=o,this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof o)throw new G("Graph.".concat(t,": updater should be a function."));return r.attributes[i]=o(r.attributes[i]),this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,i),this.emit("edgeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new G("Graph.".concat(t,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var e=arguments,t=null,n=-1;return new X(function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i})},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var o=!1;for(var r in t)if(r!==i){var s=t[r];if(o=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&o)return s.key}}function ne(e,t,n,i){var o,r,s,a=!1;for(var l in t)if(l!==i){o=t[l];do{if(r=o.source,s=o.target,a=n(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected),e&&a)return o.key;o=o.next}while(void 0!==o)}}function ie(e,t){var n,i=Object.keys(e),o=i.length,r=0;return new N(function(){do{if(n)n=n.next;else{if(r>=o)return{done:!0};var s=i[r++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}})}function oe(e,t,n,i){var o=t[n];if(o){var r=o.source,s=o.target;return i(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected)&&e?o.key:void 0}}function re(e,t,n,i){var o=t[n];if(o){var r=!1;do{if(r=i(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&r)return o.key;o=o.next}while(void 0!==o)}}function se(e,t){var n=e[t];return void 0!==n.next?new N(function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}}):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var u=r,h=u.key,d=u.attributes,m=u.source,p=u.target;if(l=i(h,d,m.key,p.key,m.attributes,p.attributes,r.undirected),e&&l)return h}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function me(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new he;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function pe(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),m=i.type;!0!==(r=d.next()).done;){var p=!1;if(s=r.value,"undirected"!==m)for(a in l=s.out){c=l[a];do{if(u=c.target,p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==m)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!p&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new G('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new G("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new G('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new G("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new G("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new G("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new q("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var m=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,m&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,m&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Ee(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new G("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new q("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;p||(p=Se(e,r,{}),v=!0,r===s&&(g=p,w=!0)),g||(g=Se(e,s,{}),w=!0),d=new z(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new G("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new G('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new G("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?U:W;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new G("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new q("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new G('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new q('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new G('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new G('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new G("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new G("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new G("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new G("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new G("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new G("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new G("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new G("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new G("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new G("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new G("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new G("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new G("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new G("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new G("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new G("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var p=s,g=p.source,f=p.target,y=p.attributes,b=p.undirected,v=void 0===b?m:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach(function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)}),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new q('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new q("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new q("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach(function(e,t){n[t]=e.attributes});var i={},o={};this._edges.forEach(function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[u]?o[u]=0:o[u]++,a+="".concat(o[u],". ")):a+="[".concat(n,"]: "),i[a+=u]=e.attributes});var r={};for(var s in this)this.hasOwnProperty(s)&&!Ce.has(s)&&"function"!=typeof this[s]&&"symbol"!==e(s)&&(r[s]=this[s]);return r.attributes=this._attributes,r.nodes=n,r.edges=i,h(r,"constructor",this.constructor),r},i}(g.exports.EventEmitter);"undefined"!=typeof Symbol&&(Te.prototype[Symbol.for("nodejs.util.inspect.custom")]=Te.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach(function(e){["add","merge","update"].forEach(function(t){var n=e.name(t),i="add"===t?xe:Ee;e.generateKey?Te.prototype[n]=function(o,r,s){return i(this,n,!0,"undirected"===(e.type||this.type),null,o,r,s,"update"===t)}:Te.prototype[n]=function(o,r,s,a){return i(this,n,!1,"undirected"===(e.type||this.type),o,r,s,a,"update"===t)}})}),function(e){K.forEach(function(t){var n=t.name,i=t.attacher;i(e,n("Node"),0),i(e,n("Source"),1),i(e,n("Target"),2),i(e,n("Opposite"),3)})}(Te),function(e){Z.forEach(function(t){var n=t.name,i=t.attacher;i(e,n("Edge"),"mixed"),i(e,n("DirectedEdge"),"directed"),i(e,n("UndirectedEdge"),"undirected")})}(Te),function(e){ee.forEach(function(t){!function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):F(e._edges.keys(),e._edges.size);for(var n,i,o="undirected"===t?e.undirectedSize:e.directedSize,r=new Array(o),s="undirected"===t,a=e._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(r[l++]=i.key);return r}(this,i);if(1===arguments.length){e=""+e;var r=this._nodes.get(e);if(void 0===r)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,i){var o=[];return le(!1,e,t,n,i,function(e){o.push(e)}),o}(this.multi,"mixed"===i?this.type:i,o,r)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i,o){var r=[];return ce(!1,e,t,n,i,o,function(e){r.push(e)}),r}(i,this.multi,o,s,t)}throw new G("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return ae(!1,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!1,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return ce(!1,i,this.multi,o,a,t,n)}throw new G("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var o=0;"directed"!==i&&(o+=this.undirectedSize),"undirected"!==i&&(o+=this.directedSize),e=new Array(o);var s=0;t.push(function(t,i,o,r,a,l,c){e[s++]=n(t,i,o,r,a,l,c)})}else e=[],t.push(function(t,i,o,r,s,a,l){e.push(n(t,i,o,r,s,a,l))});return this[r].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push(function(e,i,o,r,s,a,l){t(e,i,o,r,s,a,l)&&n.push(e)}),this[r].apply(this,e),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new G("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new G("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var i=t;return n.push(function(t,n,o,r,s,a,l){i=e(i,t,n,o,r,s,a,l)}),this[r].apply(this,n),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return ae(!0,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!0,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return ce(!0,i,this.multi,o,a,t,n)}throw new G("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push(function(e,n,i,o,r,s,a){return t(e,n,i,o,r,s,a)}),!!this[r].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push(function(e,n,i,o,r,s,a){return!t(e,n,i,o,r,s,a)}),!this[r].apply(this,e)}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,i="undirected"===t,o=e._edges.values();return new N(function(){for(var e,t;;){if((e=o.next()).done)return e;if(t=e.value,!n||t.undirected===i)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}})}(this,i);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var i=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(i=Q(i,ie(n.in))),"in"!==t&&void 0!==n.out&&(i=Q(i,ie(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(i=Q(i,ie(n.undirected))),i}(i,o,n)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i){var o=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&i in n.in&&(o=Q(o,se(n.in,i))),void 0!==n.out&&"in"!==t&&i in n.out&&(t||n.key!==i)&&(o=Q(o,se(n.out,i)))),"directed"!==e&&void 0!==n.undirected&&i in n.undirected&&(o=Q(o,se(n.undirected,i))),o}(i,o,s,t)}throw new G("Graph.".concat(r,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)})}(Te),function(e){ue.forEach(function(t){(function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var i=[];return me(!1,e,t,n,function(e){i.push(e)}),i}("mixed"===i?this.type:i,o,t)}})(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));me(!1,"mixed"===i?this.type:i,o,n,t)}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(e,t){var n=[];return this[r](e,function(e,i){n.push(t(e,i))}),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[r](e,function(e,i){t(e,i)&&n.push(e)}),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(e,t,n){if(arguments.length<3)throw new G("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[r](e,function(e,n){i=t(i,e,n)}),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n[0].toUpperCase()+n.slice(1,-1),s="find"+r;e.prototype[s]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return me(!0,"mixed"===i?this.type:i,o,n,t)}};var a="some"+r;e.prototype[a]=function(e,t){return!!this[s](e,t)};var l="every"+r;e.prototype[l]=function(e,t){return!this[s](e,function(e,n){return!t(e,n)})}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return pe(null,n,n.undirected);if("string"==typeof t)return pe(null,n,n[t])}var i=N.empty(),o=new he;return"undirected"!==e&&("out"!==t&&(i=Q(i,pe(o,n,n.in))),"in"!==t&&(i=Q(i,pe(o,n,n.out)))),"directed"!==e&&(i=Q(i,pe(o,n,n.undirected))),i}("mixed"===i?this.type:i,o,t)}}(e,t)})}(Te);var Ie=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new G("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new G('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Le=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new G("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new G('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),_e=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Te),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new G('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Pe=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new G('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te);function Re(e){e.from=function(t,n){var i=a({},t.options,n),o=new e(i);return o.import(t),o}}return Re(Te),Re(Ie),Re(Le),Re(_e),Re(Ne),Re(Pe),Te.Graph=Te,Te.DirectedGraph=Ie,Te.UndirectedGraph=Le,Te.MultiGraph=_e,Te.MultiDirectedGraph=Ne,Te.MultiUndirectedGraph=Pe,Te.InvalidArgumentsGraphError=G,Te.NotFoundGraphError=V,Te.UsageGraphError=q,Te}()},944(e,t){"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var i=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var i=0,o=e.length,r=t.length,s=Math.floor(Math.max(o,r)/2)-1,a=new Array(o),l=new Array(r),c=0;c<o;c++)for(var u=Math.max(0,c-s);u<=Math.min(r,c+s+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++i,a[c]=l[u]=!0;break}if(0===i)return 0;var h=0,d=0;for(c=0;c<o;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(i/o+i/r+(i-(h/=2))/i)/3}(e,t,n),o=0;if(i>.7){for(var r=Math.min(e.length,t.length),s=0;e[s]===t[s]&&s<4&&s<r;)++o,s++;i+=.1*o*(1-i)}return i}},7106(e){"use strict";var t=e.exports=function(e,t,i){"function"==typeof t&&(i=t,t={}),n(t,"function"==typeof(i=t.cb||i)?i:i.pre||function(){},i.post||function(){},e,"",e)};function n(e,o,r,s,a,l,c,u,h,d){if(s&&"object"==typeof s&&!Array.isArray(s)){for(var m in o(s,a,l,c,u,h,d),s){var p=s[m];if(Array.isArray(p)){if(m in t.arrayKeywords)for(var g=0;g<p.length;g++)n(e,o,r,p[g],a+"/"+m+"/"+g,l,a,m,s,g)}else if(m in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,o,r,p[f],a+"/"+m+"/"+i(f),l,a,m,s,f)}else(m in t.keywords||e.allKeys&&!(m in t.skipKeywords))&&n(e,o,r,p,a+"/"+m,l,a,m,s)}r(s,a,l,c,u,h,d)}}function i(e){return e.replace(/~/g,"~0").replace(/\//g,"~1")}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072(e){"use strict";var t=[];function n(e){for(var n=-1,i=0;i<t.length;i++)if(t[i].identifier===e){n=i;break}return n}function i(e,i){for(var r={},s=[],a=0;a<e.length;a++){var l=e[a],c=i.base?l[0]+i.base:l[0],u=r[c]||0,h="".concat(c," ").concat(u);r[c]=u+1;var d=n(h),m={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(m);else{var p=o(m,i);i.byIndex=a,t.splice(a,0,{identifier:h,updater:p,references:1})}s.push(h)}return s}function o(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,o){var r=i(e=e||[],o=o||{});return function(e){e=e||[];for(var s=0;s<r.length;s++){var a=n(r[s]);t[a].references--}for(var l=i(e,o),c=0;c<r.length;c++){var u=n(r[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}r=l}}},7659(e){"use strict";var t={};e.exports=function(e,n){var i=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540(e){"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056(e,t,n){"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825(e){"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var o=void 0!==n.layer;o&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,o&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var r=n.sourceMap;r&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),t.styleTagTransform(i,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113(e){"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},8012(e,t,n){"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>jo,PackageFunctions:()=>xs,SeqActivityCliffsEditor:()=>zo,SeqPaletteCustom:()=>Es,SequenceSpaceEditor:()=>Wo,SplitToMonomersEditor:()=>Uo,SubsequenceSearchTopMenu:()=>qr,_package:()=>As,activityCliffs:()=>dr,addCopyMenu:()=>ls,alignSequences:()=>Tr,applyNumberingScheme:()=>lr,bilnSequenceCellRenderer:()=>Xo,bioSubstructureFilter:()=>Qr,bioSubstructureFilterTest:()=>es,compositionAnalysis:()=>Lr,compositionAnalysisWidget:()=>er,convertColumnAction:()=>Rr,convertDialog:()=>Pr,customSequenceCellRenderer:()=>Yo,demoBioActivityCliffs:()=>hs,demoBioAtomicLevel:()=>ds,demoBioSequenceSpace:()=>us,demoBioSimilarityDiversity:()=>cs,detectMacromoleculeProbe:()=>fs,diversitySearchTopMenu:()=>Gr,diversitySearchViewer:()=>Dr,fastaSequenceCellRenderer:()=>Ko,getBioLib:()=>Do,getHelmMonomers:()=>Hr,getMolFromHelm:()=>bs,getMonomerLibHelper:()=>Oo,getRegion:()=>sr,getRegionApp:()=>is,getRegionHelmApp:()=>os,getRegionPanel:()=>Vo,getRegionTopMenu:()=>ar,getSeqHandler:()=>Go,getSeqHelper:()=>ys,helmPreprocessingFunction:()=>fr,importBam:()=>Nr,importFasta:()=>_r,initBio:()=>ko,libraryPanel:()=>qo,longSeqTableFasta:()=>ss,longSeqTableHelm:()=>as,longSeqTableSeparator:()=>rs,macroMolColumnPropertyPanel:()=>Qo,macromoleculeDifferenceCellRenderer:()=>nr,macromoleculePreprocessingFunction:()=>gr,manageAnnotations:()=>ur,manageLibrariesView:()=>zr,manageMonomerLibraries:()=>Wr,manageMonomerLibrariesView:()=>Kr,manageMonomerLibrariesViewTreeBrowser:()=>Zr,manageMonomersView:()=>Yr,matchWithMonomerLibrary:()=>Fo,moleculeToHelmSingle:()=>wr,moleculesToHelmTopMenu:()=>vr,monomerCellRenderer:()=>$r,monomerCollectionsApp:()=>Xr,monomerInfoPanel:()=>tr,multipleSequenceAlignmentDialog:()=>Mr,pepseaMsa:()=>Ir,refineNotationProviderForBiln:()=>Jo,saveAsFasta:()=>Jr,scanLiabilities:()=>cr,sdfToJsonLib:()=>ms,searchSubsequenceEditor:()=>Vr,separatorSequenceCellRenderer:()=>Zo,seq2atomic:()=>ps,seqActivityCliffsInitFunction:()=>mr,seqActivityCliffsTransform:()=>pr,seqIdentity:()=>gs,sequence3dStructureWidget:()=>Er,sequenceAlignment:()=>ir,sequenceColumnInput:()=>hr,sequenceIdentityScoring:()=>jr,sequenceSimilarityScoring:()=>Ur,sequenceSpaceTopMenu:()=>yr,sequenceSpaceTransform:()=>br,sequenceTooltip:()=>Ho,similaritySearchTopMenu:()=>Fr,similaritySearchViewer:()=>Br,splitToMonomersTopMenu:()=>kr,standardiseMonomerLibrary:()=>Bo,test1:()=>Ms,testDetectMacromolecule:()=>Or,toAtomicLevel:()=>Cr,toAtomicLevelAction:()=>Ar,toAtomicLevelPanel:()=>Sr,toAtomicLevelSingleSeq:()=>xr,vdRegionsViewer:()=>rr,webLogoAggApp:()=>ns,webLogoLargeApp:()=>ts,webLogoViewer:()=>or});var i,o=n(4328),r=n(7389),s=n(6082),a=n(684),l=n(9039);!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(i||(i={}));var c=n(1858),u=n(5072),h=n.n(u),d=n(7825),m=n.n(d),p=n(7659),g=n.n(p),f=n(5056),y=n.n(f),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(7939),S={};S.styleTagTransform=C(),S.setAttributes=y(),S.insert=g().bind(null,"head"),S.domAPI=m(),S.insertStyleElement=v(),h()(A.A,S),A.A&&A.A.locals&&A.A.locals;var x=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};let E=null,M=null;function T(e,t){return e&&""!=e?e:t}n(2780);class I{constructor(){this.learningRate={uiName:"Learninig Rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min Distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random Seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter(),null==E))return null;let e=null;return"info"in E&&(e=E.info),e?T(e.description,T(e.vendor,"No GPU description available")):"No GPU description available"})}().then(e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)})}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const _="MCL";s.SEMTYPE.MOLECULE,s.SEMTYPE.MACROMOLECULE;class N{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach(n=>{null!=e[n].value&&(t[n]=e[n].value)}),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=r.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=r.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[l.c.UMAP,l.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=r.inputs([]),this.dbScanSettingsDiv=r.inputs([]),this.preprocessingFuncSettingsDiv=r.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[l.c.UMAP]:new I,[l.c.T_SNE]:new L},this.dbScanParams=new N,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(_);const t=s.Func.find({tags:[a.GP]}),n=s.Func.find({meta:{role:a.GP}});Array.from(new Set([...t,...n])).forEach(e=>{const t=e.options.get(a.n3)??"",n=e.friendlyName??e.name,i=e.options.get(a.C0)??"",o=e.options.get(a._X)??"",r=e.options.get(a.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})}),this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let i=!1,c=!1;this.methodInput=r.input.choice("Method",{value:l.c.UMAP,items:this.methods,onValueChanged:e=>{i&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=r.icons.settings(()=>{i=!i,i?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):r.empty(this.methodSettingsDiv)},"Modify methods parameters"),this.dbScanSettingsIcon=r.icons.settings(()=>{c=!c,c?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):r.empty(this.dbScanSettingsDiv)},"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=r.inputs([]);const u=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=r.input.choice("Encoding function",{value:u[0],items:u,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let h=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,h=!0),h||(r.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let d=!1;this.preprocessingFuncSettingsIcon=r.icons.settings(async()=>{d?r.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),d=!d},"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=r.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find(e=>!!this.columnFunctionsMap[e.name])??null,t=r.input.column("Column",{table:this.tableInput.value,value:e,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,r.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach(e=>this.colInputRoot.append(e)),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;if(!e)return;const t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach(e=>{Object.keys(this.supportedFunctions).forEach(t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))})}),this.regenerateColInput()};t(),e.columns.toList().some(e=>!!e.getTag(s.Tags.SemanticDetectionDuration))||e.meta.detectSemanticTypes().then(()=>{t()})}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=r.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(r.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){r.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=r.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),r.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach(e=>this.similarityMetricInputRoot.append(e)),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return r.empty(e),Object.keys(t).forEach(n=>{const i=t[n],o="string"===i.type?r.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?r.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):r.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,r.tooltip.bind(o.input??o.root,i.disableTooltip??"")):r.tooltip.bind(o.input??o.root,i.tooltip)}),e}async createPreprocessingFuncParamsDiv(e,t){if(r.empty(e),t.inputs.length<3)return r.div();const n=t.prepare(),i=await n.buildEditor(r.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find(e=>e.property.name===r.name);s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe(e=>{this.preprocessingFunctionSettings[r.name]=e}),e.append(s.root))}return e}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}var R=n(9713),$=n(6295);const O=e=>null==e;function k(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class H{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),f=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=m;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),m=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(h.set(r,i),s<p&&(p=s),a>g&&(g=a),e())}})}await Promise.all(l),n&&h.forEach((e,t)=>{h[t]=(e-p)/(g-p)}),i(h)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let m=0;const p=(a+1)/n;for(let e=0;e<o;e++)r[e]<p&&(l[m]=h[e],c[m]=d[e],u[m]=r[e],m++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)k(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)k(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,D=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class G{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new D.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,t),r=this.getPointOnDistance(S,x,w,C,n,t);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new D.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var q,j=n(3629);async function U(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,j.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(q||(q={}));const W={[q.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[q.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var z;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(z||(z={}));const Y={[z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[z.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},K={[z.HAMMING]:e=>Math.ceil(e/30),[z.EUCLIDEAN]:e=>Math.ceil(e/30),[z.MANHATTAN]:e=>Math.ceil(e/30),[z.TANIMOTO]:e=>Math.ceil(e/30),[z.SOKAL]:e=>Math.ceil(e/30),[z.COSINE]:e=>Math.ceil(e/30),[z.ASYMMETRIC]:e=>Math.ceil(e/30),[z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[z.Difference]:e=>1,[z.OneHot]:e=>Math.ceil(e/40),[z.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([z.HAMMING,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.MONOMER_CHEMICAL_DISTANCE,z.OneHot]),UINT32ARRAY:new Set([z.HAMMING,z.EUCLIDEAN,z.MANHATTAN,z.MONOMER_CHEMICAL_DISTANCE,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.TANIMOTO,z.COSINE,z.VECTOR_COSINE,z.SOKAL,z.ASYMMETRIC,z.OneHot,z.Difference]),INT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.OneHot,z.Difference,z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference,z.VECTOR_COSINE]),NUMBER:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference]),BITARRAY:new Set([z.TANIMOTO,z.COSINE,z.SOKAL,z.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield E.requestDevice(),M}}return M})}();if(!s)return null;const a=Object.values(z);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(q).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map((e,t)=>function(e,t=z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=K[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===z.NEEDLEMAN_WUNSCH||t===z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/f),T=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${J(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),L=new Uint32Array(f),_=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(A/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?A-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);L[e]=O,_[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),H=h.reduce((e,t)=>e+t.suppInfoSize,0),B=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let D=F;const G=15&F;0!==G&&(D+=16-G);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let U=0;new Uint32Array(j,U,f).set(L),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(_),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(N),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(P),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g.length).set(g),U+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const W=H*Uint32Array.BYTES_PER_ELEMENT;let Y=W;const X=15&W;0!==X&&(Y+=16-X),Y=Math.max(Y,16);const Q=s.createBuffer({label:"supp info buffer",size:Y,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,B);o+=B*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),Q.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function J(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${Y[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${W[i](e.length)}\n }\n \n `}var Q=n(1991),ee=n.n(Q);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,n,i,a,l,c,u,h,d,m,p,g,f,y,b){te++;const v=c/100;let w,C=!1;const A=o.shell.tv?.dataFrame===t?o.shell.tv:o.shell.getTableView(t.name);let S=null;if(h.useWebGPU)try{S=await X([i.entries],v,[u],q.MANHATTAN,[1],[i.options??{}])}catch(e){console.error(e)}S||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),S=await(new B).calc(i.entries,u,v,i.options));const x=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,a=s.BitSet.create(t.length);return e.distance.forEach((t,n)=>{a.set(e.i[n],!0),a.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:a}}(S,a),E=`sali_${l[0].substring(l[0].lastIndexOf("_"))}`;if(!t.columns.names().includes(E)){const i=function(e,t,n,i,o,r,a){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(a.get(i[e])>a.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return s.Column.fromList("double",t,l)}(n.length,E,x.saliVals,x.n1,x.n2,0,a);t.columns.add(i),e.setOptions({size:i.name})}const M=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(x.saliVals),T=.8/(M.max-M.min),I=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(t,x,n,a,d,m,M,T);I.lines.skipMultiLineCalculation=!0,I.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const L=new G(e,l[0],l[1],I.lines,F.none);let _=null;const N=r.button(`${I.linesDf.rowCount} cliffs`,()=>{if(!_?.dataFrame){_=(()=>{const e=f?f(I.linesDf,se).sort([oe],[!1]):I.linesDf.plot.grid().sort([oe],[!1]);return e.col(re)&&(e.col(re).visible=!1),t.temp[".cliffsDfGrid"]=_,e})();const e=ee()(A.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);b&&!e&&A.addViewer(_),A.dockManager.dock(_,"down",void 0,"Activity cliffs",y??.2)}});N.classList.add("scatter_plot_link","cliffs_grid");const P=r.input.toggle("Show only cliffs",{value:!1,onValueChanged:n=>{n?(e.dataFrame.setTag(ae,l[0]),t.filter.and(x.cliffsBitSet),ie.next(l[0])):(e.dataFrame.setTag(ae,""),t.filter.setAll(!0),ie.next(""))}});e.root.prepend(r.divH([N,P.root],"cliffs_div")),ie.subscribe(e=>{P.enabled=""===e||e===l[0]}),t.onRowsFiltering.subscribe(()=>{P.value&&t.filter.and(x.cliffsBitSet)});const $=o.events.onViewerClosed.subscribe(t=>{t.args.viewer===e&&(_&&A.dockManager.close(_.root),$.unsubscribe(),A.subs=A.subs.filter(e=>e!==$))});A.subs.push($),I.linesDf.onCurrentCellChanged.subscribe(()=>{for(let e=0;e<I.linesDf.rowCount;e++)I.lines.widths[e]=e===I.linesDf.currentRowIdx?3:1;L.linesToRender=I.lines;const i=I.linesDf.currentCol&&I.linesDf.currentCol.name===se[1]?I.lines.to:I.lines.from,s=-1!==I.linesDf.currentRowIdx?I.linesDf.currentRowIdx:null;if(e.dataFrame.currentRowIdx=s?i[s]:-1,null!==s){const i=I.linesDf.currentRowIdx;L.currentLineId=i;const{zoomLeft:c,zoomRight:u,zoomTop:h,zoomBottom:d}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<o?n:o)+s/2-h/2,p=(i>r?i:r)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(e.viewport.width,e.viewport.height,e.dataFrame.get(l[0],I.lines.from[i]),e.dataFrame.get(l[1],I.lines.from[i]),e.dataFrame.get(l[0],I.lines.to[i]),e.dataFrame.get(l[1],I.lines.to[i]));e.zoom(c,h,u,d),P.value?t.filter.and(x.cliffsBitSet):!0===P.enabled&&t.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,s,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:s,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout(()=>{o.shell.o=t.root},500)}(t,w,I.lines.from[s],I.lines.to[s],s,n,a,I.linesDf.get(oe,s),g);const i=e.dataFrame.getSortedOrder(A.grid.sortByColumns,A.grid.sortTypes);A.grid.scrollToCell(n.name,i.indexOf(e.dataFrame.currentRowIdx))},1e3)}}),I.linesDf.onSelectionChanged.subscribe(e=>{setTimeout(()=>(()=>{const e=s.BitSet.create(t.rowCount);for(let t=0;t<I.linesDf.rowCount;t++){const n=I.linesDf.selection.get(t);n&&(e.set(I.lines.from[t],!0),e.set(I.lines.to[t],!0)),I.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),L.linesToRender=I.lines})(),100)}),t.onSelectionChanged.subscribe(e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(!C&&_?.dataFrame?(e=>{e.selection.setAll(!1);for(let e=0;e<I.lines.colors.length;e++)I.lines.colors[e]="0,128,0";L.linesToRender=I.lines})(_.dataFrame):C=!1)}),L.lineClicked.subscribe(e=>{if(C=!0,L.currentLineId=e.id,-1!==e.id){const n=I.linesDf.selection.clone();setTimeout(()=>{if(e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),I.linesDf.selection.copyFrom(n)):(I.linesDf.currentRowIdx!==e.id&&(I.linesDf.currentRowIdx=e.id,t.currentRowIdx=I.lines.from[e.id]),I.linesDf.selection.copyFrom(n)),_?.dataFrame){const t=I.linesDf.getSortedOrder(_.sortByColumns,_.sortTypes);_.scrollToCell(se[0],t.indexOf(e.id))}},500)}}),L.lineHover.pipe((0,R.debounceTime)(500)).subscribe(e=>{-1!==e.id&&-1===t.mouseOverRowIdx&&r.tooltip.show(p({lineId:e.id,points:[I.lines.from[e.id],I.lines.to[e.id]],df:t,seqCol:n,activityCol:a}),e.x,e.y)}),e.addProperty("similarityLimit","double",v),w=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}()}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151),me=n(4025),pe=n(439);function ge(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getOriginal(o);(n(o)||i(o)).set(e,r,!1)}}const c=e.temp[me.j.notationProvider]??null,u=c?.monomerCanonicalizerFuncName;if(u)for(const e of o)e.setTag(pe.jz,u);return a}var fe,ye=n(4971);async function be(e){const t=(await(0,ye.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var ve=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ce extends P{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[_]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,Se,xe;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Me(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Te(e,t,i,l,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==l.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=s.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=g.embedColsNames??Ee(e);function x(n,o,l){let c=null,u=null;e.columns.names().includes(S[0])?(c=e.columns.byName(S[0]),u=e.columns.byName(S[1])):(c=e.columns.add(s.Column.float(S[0],e.rowCount)),u=e.columns.add(s.Column.float(S[1],e.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}))),g[a.YP]&&(A?.root&&r.setUpdateIndicator(A.root,!1),c.init(e=>l[0]?l[0][e]:void 0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function E(){e.columns.add(s.Column.float(S[0],e.rowCount)),e.columns.add(s.Column.float(S[1],e.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}),r.setUpdateIndicator(A.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await U(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:x))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await E();if(m&&M){const T=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),L=g.clusterColName??e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(L).init(e=>I[e].toString()),A&&(A.props.colorColumnName=L)}catch(_){o.shell.error("Clustering embeddings failed"),console.error(_)}finally{T.close()}}if(M){const N=e.columns.byName(S[0]),P=e.columns.byName(S[1]);if(N.init(e=>M[0][e]),P.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return r.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&r.setUpdateIndicator(A.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Se||(Se={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(xe||(xe={})),Object.prototype.toString;var Ie=n(6873),Le=n(4356),_e=n(6717);function Ne(e){var t;if((null===(t=o.shell.tv)||void 0===t?void 0:t.dataFrame)===e)return;const n=o.shell.tableView(e.name);n?o.shell.v=n:o.shell.addTableView(e)}var Pe=n(4870),Re=n(3856),$e=n(6882),Oe=n(7278),ke=n(5553),He=n(6642),Be=n(3599),Fe=n(673),De=n(8312);class Ge extends He.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,As.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,De.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ve=n(4139);const qe=ue.zS;function je(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class Ue extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=As.seqHelper}getRendererBack(e){const[t,n,i]=(0,He.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,ke.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,He.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(As.properties?As.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new $e.Jy(a,l,As.logger,d,()=>{const{font:e,fontWidth:t}=$e.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:qe}}),l.temp[".mm.cellRenderer.settingsChanged"],Fe.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class We extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator];let h=this.tableCol.meta.units;i=(0,$e.U0)(l,e,t,i,a);const[d,m]=c.split("#");h!==ue.Hi.CUSTOM||this.tableCol.temp[me.j.notationProvider]||(h=ue.Hi.SEPARATOR);const p=this.tableCol.temp[me.j.notationProvider]?.separatorSplitter??this.tableCol.temp[me.j.notationProvider]?.splitter??(0,Oe.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getOriginal(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getOriginal(e)).toArray(),v=this.tableCol.getTag(ue.gp.alphabet);Ye(e,t,n,i,o,y,b,v===ue.YI.RNA||v===ue.YI.DNA?Be.o.NUCLEOTIDE:Be.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new We(t,n)),o}}class ze extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ve.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){We.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Ye(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(pe.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(je(r).join("")),d=e.measureText(je(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=$e.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=$e.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Re.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Re.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ke(n,c,d,r,g,h,o))}else p=(0,Re.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ke(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(je([e]).join("")).width,u=l.measureText(je([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Ze,Xe=n(8070),Je=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Ze||(Ze={}));const Qe=new class{constructor(){this.regionTypes=[Ze.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Je.fH.Entropy,this.filterSource=Je.Fo.filterSource}};var et=n(7602),tt=n(250);const nt=Ze;var it,ot;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(it||(it={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ot||(ot={}));const rt=Qe;class st extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ot.skipEmptyPositions,rt.skipEmptyPositions,{category:it.DATA}),this.regionTypes=this.stringList(ot.regionTypes,rt.regionTypes,{category:it.DATA,choices:Object.values(nt).filter(e=>e!=nt.Unknown)}),this.chains=this.stringList(ot.chains,rt.chains,{category:it.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ot.fitWidth,rt.fitWidth,{category:it.LAYOUT}),this.positionWidth=this.float(ot.positionWidth,rt.positionWidth,{category:it.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ot.positionHeight,rt.positionHeight,{category:it.LAYOUT,choices:Object.keys(Je.fH)}),this.filterSource=this.string(ot.filterSource,rt.filterSource,{category:it.BEHAVIOR,choices:Object.values(Je.lT)}),this.viewSyncer=new et.g(As.logger)}static viewerCounter=-1;viewerId=++st.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case ot.regionTypes:case ot.chains:this.setData(this.regions)}switch(e.name){case ot.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ot.fitWidth:case ot.positionWidth:this.calcSize();break;case ot.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ot.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;As.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){As.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){As.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);r&&i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Je.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),As.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){As.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[tt.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(ot.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[tt.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Xe.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class at{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class lt{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class ct{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new lt(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new at);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new at);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ut(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=As.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,ye.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await be(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await be(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ht=n(4954);function dt(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function mt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=As.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=gt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(ft(i)),t.append(pt("Activity delta",Math.abs(n[0]-n[1]))),t.append(pt("Cliff",e.sali)),t}function pt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function gt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=As.monomerLib;return Ye(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function ft(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function yt(e,t){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class bt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class vt extends bt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const wt={gapPenalty:1,matchScore:1,gapSymbol:pe.b9[pe.Hi.FASTA],localAlignment:!1};class Ct extends vt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Pe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Pe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ut(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new B).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...wt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new Oe.Mu(d,i.gapSymbol),seq2Splitted:new Oe.Mu(m,i.gapSymbol)}}(c,u),d=gt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(ft(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class At extends vt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Pe.Kd)(i,t.name,450,30),(0,Pe.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ut(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new H(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var St=n(5433),xt=n(3736),Et=n(4517);class Mt{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Tt={A:new D.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new D.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new D.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new D.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new D.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new D.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new D.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new D.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new D.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new D.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new D.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new D.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},It={RNA:{A:new D.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new D.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new D.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new D.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new D.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:Tt};async function Lt(e,t,n=0){if(!Object.keys(It).includes(t))return null;const i=await async function(e){const t=s.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new D.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!It[t])return null;const o=It[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var _t;!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(_t||(_t={}));class Nt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Pt extends Nt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Rt extends Pt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(_t.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(_t.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(_t.TYPE)&&-1!==e.indexOf(_t.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,_t.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<_t.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,_t.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,_t.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+_t.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=_t.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t extends Pt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ot{constructor(){}static getInstance(e){if(Ot.isMolfileV2K(e))return new Rt(e);if(Ot.isMolfileV3K(e))return new $t(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Rt.isValidMolfile(e)}static isMolfileV3K(e){return $t.isValidMolfile(e)}}var kt=n(6197),Ht=n(9124),Bt=n(3527);class Ft{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Ft.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Dt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Gt extends Ft{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Vt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class qt extends Ft{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class jt extends Ft{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Ut{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new jt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Ut(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Wt={[Be.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Be.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Be.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Be.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Be.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Be.o.CHEM]:{R:"#eeeeee"},[Be.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},zt=/.*\|\$.*R.*\$\|/,Yt=/\[R(\d+)\]/,Kt=/\[R(\d+)\]/g,Zt=/\[\*:(\d+)\]/g;function Xt(e,t){const n=Array.from(e.matchAll(Kt)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=Hn(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){As.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const Jt=/[\w()]+/,Qt=RegExp(String.raw`\(${Jt}(,${Jt})+\)`),en=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},tn=new Bt.Mi([255,255,255]),nn=new Bt.Mi([0,0,0]),on=.7*(0,j.wQ)(tn);class rn{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==pe._S||t===pe.b9[pe.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(zt.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return Xt(a,t)}let n=e;const i=Array.from(e.matchAll(Zt));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(Yt.test(n))return Xt(n,t)}catch(t){As.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Dt((0,Oe.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,Ht.fA)(e,t),o=(0,kt.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Be.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Be.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===pe._S||"*"==i?s=r.wem=new Gt(n):n===Be.o.NUCLEOTIDE&&"N"===i||n===Be.o.AA&&"X"===i||(Be.o.CHEM,0)||Qt.test(i)?s=r.wem=new Vt(n,i):r.lib||(s=r.wem=new qt(n,i,this.isEmpty)),s||(s=r.wem=Ut.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,kt.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?en(s.molfile):s.smiles?r.divV([en(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=pe._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Bt.Mi([...o.map(e=>e+1)]),a=(0,j.KE)(r,tn)/((0,j.wQ)(r)*(0,j.wQ)(tn)),l=i(n.backgroundcolor),c=new Bt.Mi([...l.map(e=>e+.01)]);let u;u=(0,j.KE)(c,tn)/((0,j.wQ)(c)*(0,j.wQ)(tn))<a?l:o;let h=new Bt.Mi(u);const d=(0,j.wQ)(h);return d>on&&(h=(0,j.dC)(nn,h,on/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,kt.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){As.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Wt[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var sn=n(5488),an={};an.styleTagTransform=C(),an.setAttributes=y(),an.insert=g().bind(null,"head"),an.domAPI=m(),an.insertStyleElement=v(),h()(sn.A,an),sn.A&&sn.A.locals&&sn.A.locals;class ln extends rn{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,kt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Ot.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Le.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new cn(e,`override: ${++ln.overrideCounter}, ${t}`,this)}}class cn extends rn{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var un=n(8604),hn=n(7433),dn=n.n(hn),mn=n(1913),pn=n.n(mn);class gn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(dn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});pn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class fn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=ye.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText(fn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new gn(i);fn._instance=new fn(r,e,t),fn._instance.refreshLists()}return fn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new ye.lH(n,i,o,r,s)});t.push(new ye.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}const yn="System:AppData/Bio/monomer-collections/";class bn{logger;_monomerLib=new ln({},"MAIN");_monomerSets=new ye.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await s.delay(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await fn.getInstance(this,As.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++bn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return bn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Le.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new ln(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Le.E)(un.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new ln(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===ye.ic);if(!t)throw new Error(`Provider '${ye.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new ln(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,ye.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async listMonomerCollections(){return(await o.dapi.files.list(yn)).filter(e=>"json"===e.extension||e.name.endsWith(".json")).map(e=>e.name)}async deleteMonomerCollection(e){e.endsWith(".json")||(e+=".json"),await o.dapi.files.exists(yn+e)&&await o.dapi.files.delete(yn+e)}async readMonomerCollection(e){e.endsWith(".json")||(e+=".json");const t=await o.dapi.files.readAsText(yn+e);return JSON.parse(t)}async addOrUpdateMonomerCollection(e,t,n,i){e.endsWith(".json")||(e+=".json");const r=JSON.stringify({description:n,tags:i,monomerSymbols:t,updatedBy:s.User.current().login,updatedOn:(new Date).toISOString()},null,2);await o.dapi.files.writeAsText(yn+e,r)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new bn(As.logger))()),e}}var vn=n(857),wn={};wn.styleTagTransform=C(),wn.setAttributes=y(),wn.insert=g().bind(null,"head"),wn.domAPI=m(),wn.insertStyleElement=v(),h()(vn.A,wn),vn.A&&vn.A.locals&&vn.A.locals;const Cn=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];function An(e,t,n){let i=t[e]??n[e];if(i&&i.length>0)return i;const r=Bn(e,Cn);if(r!==e){const e=o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles);if(i=t[e]??n[e],i&&i.length>0)return i}return[]}function Sn(e){const t=new Set;return e.filter(e=>!t.has(e.symbol)&&(t.add(e.symbol),!0))}function xn(e,t){const n=new Set;for(const i of e){const e=t[i.symbol];if(e&&e.length>0)for(const t of e){const e=t?.lib?.source;e&&n.add(e)}else i.source&&n.add(i.source)}return Array.from(n).join(", ")}var En;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(En||(En={}));const Mn={[En.MONOMER]:s.COLUMN_TYPE.STRING,[En.SYMBOL]:s.COLUMN_TYPE.STRING,[En.NAME]:s.COLUMN_TYPE.STRING,[En.R_GROUPS]:s.COLUMN_TYPE.STRING,[En.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[En.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[En.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[En.AUTHOR]:s.COLUMN_TYPE.STRING,[En.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[En.ID]:s.COLUMN_TYPE.INT,[En.META]:s.COLUMN_TYPE.STRING,[En.SOURCE]:s.COLUMN_TYPE.STRING};async function Tn(e){const t=await In(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>Fn(t.rows.get(n))))}async function In(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Mn))if(t.columns.addNew(e,n),e===En.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(En.SYMBOL).semType="Monomer",t.col(En.SYMBOL).setTag(Re.Mn.applyToBackground,"true"),t.col(En.SYMBOL).setTag(pe.qE.polymerTypeColumnName,En.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=kn(e[n].rgroups,e[n].smiles,e[n].molfile);o=_n(o),e[n].rgroups=$n(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?Pn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(En.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(En.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class Ln{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(En.NAME).width=100,this.tv.grid.col(En.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new On(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(En.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await bn.getInstance();await e.awaitLoaded(),this.instance=new Ln(e)}return this.instance}static async getNewInstance(){const e=await bn.getInstance();return await e.awaitLoaded(),new Ln(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewMonomersCollectionDialog(e){const t=(await this.monomerLibManamger.listMonomerCollections()).map(e=>e.toLowerCase()),n=r.input.string("Collection Name",{tooltipText:"Name of the monomer collection, should be unique",placeholder:"Enter collection name",nullable:!1}),i=r.input.string("Description",{tooltipText:"Description of the monomer collection",placeholder:"Enter collection description",nullable:!0}),s=r.dialog("Create New Monomer Collection").add(n).add(i).addButton("Add",async()=>{if(!n.value||!n.value.trim())return void o.shell.warning("Collection name cannot be empty");const a=async e=>{await this.monomerLibManamger.addOrUpdateMonomerCollection(n.value,e,i.value??void 0),o.shell.info(`Collection ${n.value} saved successfully`)};if(t.includes(n.value.toLowerCase())||t.includes(n.value.toLowerCase()+".json")){const t=r.dialog("Collection already exists").add(r.divText(`A collection with the name ${n.value} already exists. Do you want to merge or overwrite it?`));t.addButton("Merge",async()=>{const i=await this.monomerLibManamger.readMonomerCollection(n.value),r=Array.from(new Set([...i.monomerSymbols??[],...e]));try{await a(r)}catch(e){o.shell.error("Error merging monomer collection"),console.error(e)}t.close()}),t.addButton("Overwrite",async()=>{try{await a(e)}catch(e){o.shell.error("Error overwriting monomer collection"),console.error(e)}t.close()}),t.show()}else try{await a(e)}catch(e){o.shell.error("Error creating monomer collection"),console.error(e)}s.close()}).show()}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex,n=e.menu;if(n.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),n.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0){const e=n.group("Selected Monomers");e.item("Remove",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Fn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.item("Create Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Fn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}),e.item("Create Collection",async()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>this.tv.dataFrame.col(En.SYMBOL).get(e)).filter(e=>!!e&&e.trim().length>0);if(0===e.length)return o.shell.warning("No valid monomer symbols found in selection");this.createNewMonomersCollectionDialog(e)})}else n.item("Remove Monomer",async()=>{const e=await Fn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===Ln.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:Ln.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Fn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Fn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=Ln.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Fn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,ye.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await In(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Fn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const Nn=["alternateId","capGroupName","capGroupSMILES","label"];function Pn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Rn(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function $n(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(Nn,e),n=Pn(t,"capGroupSMILES"),i=Pn(t,"alternateId"),o=Pn(t,"capGroupName"),r=Pn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class On{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Dn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=kn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Lt(Bn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Mt(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Mt(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=$n(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&Lt(Bn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=kn(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(En.POLYMER_TYPE)?.toList()??[],s=n?.col(En.SYMBOL)?.toList()??[],a=n?.col(En.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await Fn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await Fn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=kn([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=Hn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function kn(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=_n(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function Hn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function Bn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=Pn(e,"capGroupName"),r=Pn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function Fn(e){let t;try{t=JSON.parse(e.get(En.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(En.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=Hn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(En.NATURAL_ANALOG);const a=e.get(En.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(En.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=Pn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?Rn(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?Rn(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?Rn(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&Rn(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=Pn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&Rn(e,"capGroupSMILES",`${Pn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await Lt(Bn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(En.SYMBOL),name:e.get(En.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(En.MONOMER_TYPE),naturalAnalog:r,id:e.get(En.ID),rgroups:l,meta:t,author:e.get(En.AUTHOR),createDate:e.get(En.CREATE_DATE)}}class Dn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}function Gn(e){const t={Symbol:e.symbol,Name:e.name,"Polymer Type":e.polymerType,"Monomer Type":e.monomerType};if(e.author&&(t.Author=e.author),e.naturalAnalog&&(t["Natural Analog"]=e.naturalAnalog),e.lib?.source){let n=e.lib.source;n.endsWith(".json")&&(n=n.substring(0,n.length-5)),t.Library=n}e.molfile?t.Structure=o.chem.drawMolecule(e.molfile,150,150):e.smiles&&(t.Structure=o.chem.drawMolecule(e.smiles,150,150));const n=e.rgroups;if(n&&n.length>0)for(const e of n)t[e.label??"?"]=e.alternateId??"";return r.tableFromMap(t)}function Vn(e){const t=function(e){try{return Bn(kn(e.rgroups,e.smiles,e.molfile),e.rgroups)}catch{}return null}(e);if(!t)return r.divText("No molecular structure available");const n=s.SemanticValue.fromValueType(t,s.SEMTYPE.MOLECULE);return r.panels.infoPanel(n).root}var qn=n(3890),jn=n(1687);function Un(e){return e.split(/,(?![^(]*\))/).map(e=>('"'===(e=e.trim()).slice(0,1)&&'"'===e.slice(-1)&&(e=e.slice(1,-1)),"'"===e.slice(0,1)&&"'"===e.slice(-1)&&(e=e.slice(1,-1)),e.trim())).filter(e=>!!e)}class Wn{constructor(e,t,n,i){this.currentMenu=null,this.menuItems=[],this.highlightedIndex=-1,this.monomerLib=e,this.polymerType=t,this.helmType=(0,Oe.MD)(t),this.allSymbols=e.getMonomerSymbolsByType(t),this.libHelper=i,this.selectedMonomers=n?[...n]:[],this.tagsHost=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px",marginTop:"4px",maxHeight:"150px",overflowY:"auto"}}),this.countLabel=r.divText("",{style:{fontSize:"11px",color:"var(--grey-4)",marginTop:"4px"}});const o=r.input.string("Search",{value:""});this.inputEl=o.input,this.inputEl.setAttribute("autocomplete","off"),this.inputEl.placeholder="Type to search monomers...",this.setupInputListeners();const s=this.createLibrarySection(),a=this.createCollectionSection(),l=r.button("Clear all",()=>{this.selectedMonomers.length=0,this.renderTags()});l.style.fontSize="11px",l.style.marginTop="4px",this.renderTags(),this.root=r.div([o.root,s,a,r.divH([this.countLabel,l],{style:{justifyContent:"space-between",alignItems:"center"}}),this.tagsHost],{style:{minWidth:"300px"}})}getSelectedMonomers(){return[...this.selectedMonomers]}setSelectedMonomers(e){this.selectedMonomers.length=0,this.selectedMonomers.push(...e),this.renderTags()}setPolymerType(e){this.polymerType=e,this.helmType=(0,Oe.MD)(e),this.allSymbols=this.monomerLib.getMonomerSymbolsByType(e)}focus(){this.inputEl.focus()}updateCountLabel(){this.countLabel.textContent=this.selectedMonomers.length>0?`${this.selectedMonomers.length} monomer(s) selected`:""}renderTags(){this.tagsHost.innerHTML="";for(const e of this.selectedMonomers){const t=r.iconFA("times",()=>{const t=this.selectedMonomers.indexOf(e);t>=0&&(this.selectedMonomers.splice(t,1),this.renderTags(),this.updateCountLabel())});t.style.marginLeft="4px",t.style.cursor="pointer";const n=r.div([r.span([e]),t],{style:{display:"inline-flex",alignItems:"center",padding:"2px 6px",borderRadius:"4px",backgroundColor:"var(--grey-2)",border:"1px solid var(--grey-3)",fontSize:"12px",cursor:"default"}});n.addEventListener("mouseenter",()=>{const t=this.monomerLib.getTooltip(this.helmType,e);r.tooltip.show(t,n.getBoundingClientRect().left,n.getBoundingClientRect().bottom+16)}),n.addEventListener("mouseleave",()=>{r.tooltip.hide()}),this.tagsHost.appendChild(n)}this.updateCountLabel()}addMonomer(e){this.selectedMonomers.includes(e)||(this.selectedMonomers.push(e),this.renderTags()),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}addMonomers(e){let t=!1;for(const n of e)this.selectedMonomers.includes(n)||(this.selectedMonomers.push(n),t=!0);t&&this.renderTags()}hideMenu(){this.currentMenu&&(this.currentMenu.hide(),this.currentMenu=null),this.menuItems=[],this.highlightedIndex=-1}getSuggestions(e){const t=e.toLowerCase(),n=[];for(const e of this.allSymbols){if(this.selectedMonomers.includes(e))continue;const i=this.monomerLib.getMonomer(this.polymerType,e),o=e.toLowerCase(),r=i?.name?.toLowerCase()??"";o.startsWith(t)?n.push({symbol:e,monomer:i,rank:0}):o.includes(t)?n.push({symbol:e,monomer:i,rank:1}):r.includes(t)&&n.push({symbol:e,monomer:i,rank:2})}return n.sort((e,t)=>e.rank-t.rank||e.symbol.localeCompare(t.symbol)),n.slice(0,20)}showSuggestions(){this.hideMenu();const e=this.inputEl.value.trim();if(!e)return;const t=this.getSuggestions(e);if(0===t.length)return;this.currentMenu=s.Menu.popup();const n=t.reduce((e,t)=>{const n=t.monomer?.name?`${t.symbol} - ${t.monomer.name}`:t.symbol;return e.length<n.length?n:e},"");this.currentMenu.item(n,()=>{});const i=new MouseEvent("mousemove",{clientX:this.inputEl.getBoundingClientRect().left,clientY:this.inputEl.getBoundingClientRect().bottom});this.currentMenu.show({causedBy:i,y:this.inputEl.offsetHeight+this.inputEl.offsetTop,x:this.inputEl.offsetLeft}),setTimeout(()=>{this.currentMenu?.clear();for(const e of t){const t=e.monomer?.name?`${e.symbol} - ${e.monomer.name}`:e.symbol;this.currentMenu?.item(t,()=>{this.addMonomer(e.symbol)})}const e=document.querySelector(".d4-menu-popup:last-of-type");e&&(this.menuItems=Array.from(e.querySelectorAll(".d4-menu-item"))),this.highlightedIndex=-1},0)}updateHighlight(e){0!==this.menuItems.length&&(this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&this.menuItems[this.highlightedIndex].classList.remove("d4-menu-item-hover"),this.highlightedIndex=e,this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&(this.menuItems[this.highlightedIndex].classList.add("d4-menu-item-hover"),this.menuItems[this.highlightedIndex].scrollIntoView({block:"nearest"})))}setupInputListeners(){this.inputEl.addEventListener("input",()=>{this.showSuggestions()}),this.inputEl.addEventListener("paste",e=>{const t=e.clipboardData?.getData("text");if(!t)return;const n=t.split(/[\n\r]+/).map(e=>e.trim()).filter(e=>e.length>0),i=[];for(const e of n){const t=Un(e);1===t.length&&e.includes(" ")&&!e.includes(",")?i.push(...e.split(/\s+/).map(e=>e.trim()).filter(e=>e.length>0)):i.push(...t)}if(!(i.length<=1)){e.preventDefault();for(const e of i)this.selectedMonomers.includes(e)||this.selectedMonomers.push(e);this.renderTags(),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}}),this.inputEl.addEventListener("keydown",e=>{if("ArrowDown"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex+1)%this.menuItems.length;this.updateHighlight(e)}}else if("ArrowUp"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex-1+this.menuItems.length)%this.menuItems.length;this.updateHighlight(e)}}else if("Enter"===e.key)if(e.preventDefault(),e.stopPropagation(),this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length)this.menuItems[this.highlightedIndex].click();else{const e=this.inputEl.value.trim();e&&this.addMonomer(e)}else"Escape"===e.key&&this.hideMenu()})}createLibrarySection(){const e=r.div([],{style:{marginTop:"8px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from library",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.getAvaliableLibraryNames().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=await t.readSingleLibraryByName(e);if(n){const t=n.getMonomerSymbolsByType(this.polymerType),o=this.selectedMonomers.length;this.addMonomers(t);const r=this.selectedMonomers.length-o;i.textContent=`Added ${r} monomer(s) from "${e}"`}else i.textContent=`Library "${e}" not found`}catch(e){i.textContent="Error loading library"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}createCollectionSection(){const e=r.div([],{style:{marginTop:"4px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from collection",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.listMonomerCollections().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=(await t.readMonomerCollection(e)).monomerSymbols??[],o=this.selectedMonomers.length;this.addMonomers(n);const r=this.selectedMonomers.length-o,s=e.replace(/\.json$/,"");i.textContent=`Added ${r} monomer(s) from "${s}"`}catch(e){i.textContent="Error loading collection"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}}class zn extends s.ObjectHandler{get type(){return"MonomerCollection"}get name(){return"Monomer Collection"}isApplicable(e){return Array.isArray(e)?e.length>0&&e.every(e=>this.isSingleCollection(e)):this.isSingleCollection(e)}isSingleCollection(e){return null!=e&&"object"==typeof e&&"name"in e&&"displayName"in e&&"data"in e&&void 0!==e.data?.monomerSymbols}getCaption(e){return Array.isArray(e)?`${e.length} collections`:e.displayName}renderProperties(e,t=null){return Array.isArray(e)?this.renderMultiProperties(e):this.renderSingleProperties(e)}renderSingleProperties(e){const t=r.accordion("Monomer Collection"),n=s.User.current().login,i=e.data.updatedBy===n;return t.addPane("Details",()=>{const t={Name:e.displayName};if(e.data.description&&(t.Description=e.data.description),e.data.tags&&e.data.tags.length>0&&(t.Tags=e.data.tags.join(", ")),t.Monomers=`${e.data.monomerSymbols.length}`,e.data.updatedBy&&(t["Updated by"]=e.data.updatedBy),e.data.updatedOn)try{t["Updated on"]=new Date(e.data.updatedOn).toLocaleString()}catch{}return r.tableFromMap(t)},!0),t.addPane("Monomers",()=>{const t=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px"}}),n=this.getMonomerLib();for(const i of e.data.monomerSymbols){const e=r.div([i],{style:{display:"inline-block",padding:"2px 8px",borderRadius:"4px",background:"var(--grey-1)",border:"1px solid var(--grey-2)",fontSize:"11px",color:"var(--grey-5)",cursor:"pointer"}});e.addEventListener("mouseenter",()=>{if(n){const t=zn.getMonomerTooltipSafe(n,i);if(t){const n=e.getBoundingClientRect();r.tooltip.show(t,n.left,n.bottom+4)}}}),e.addEventListener("mouseleave",()=>r.tooltip.hide()),e.addEventListener("click",()=>{o.shell.o=s.SemanticValue.fromValueType(i,Ve.uF.MONOMER)}),t.appendChild(e)}return t},!0),t.addPane("Actions",()=>{const t=[],n=r.button("Edit",async()=>{i&&await this.editCollection(e)},i?"Edit this collection":"Only the author can edit");i||zn.disableButton(n),t.push(n);const o=r.button("Delete",async()=>{i&&await this.deleteCollection(e)},i?"Delete this collection":"Only the author can delete");return i||zn.disableButton(o),t.push(o),t.push(r.button("Duplicate",async()=>{await this.duplicateCollection(e)},"Create a copy of this collection")),r.divH(t)},!0),t.root}renderMultiProperties(e){const t=r.accordion("Monomer Collections"),n=s.User.current().login,i=e.every(e=>e.data.updatedBy===n);return t.addPane("Selection",()=>{const t=r.list(e.map(e=>e.displayName));return r.divV([r.divText(`${e.length} collections selected`),t])},!0),t.addPane("Actions",()=>{const t=[];t.push(r.button("Merge",async()=>{await this.mergeCollections(e)},"Merge selected collections into one"));const n=r.button("Delete All",async()=>{i&&await this.deleteMultipleCollections(e)},i?"Delete all selected collections":"Only the author can delete (you must be author of all)");return i||zn.disableButton(n),t.push(n),r.divH(t)},!0),t.root}async editCollection(e){const t=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(t&&t._mcView)t._mcView.editCollectionPublic(e.name,e.data);else{const t=await bn.getInstance();await t.awaitLoaded();const n=t.getMonomerLib();this.showEditDialog(e,t,n)}}showEditDialog(e,t,n){const i=r.input.string("Name",{value:e.displayName,nullable:!1}),s=r.input.string("Description",{value:e.data.description??"",nullable:!0}),a=r.input.string("Tags",{value:(e.data.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(n,l.value,[...e.data.monomerSymbols??[]],t);l.onChanged.subscribe(()=>c.setPolymerType(l.value)),r.dialog({title:`Edit Collection: ${e.displayName}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const n=i.value?.trim();if(!n)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=this.parseTags(a.value);try{n!==e.displayName&&await t.deleteMonomerCollection(e.name),await t.addOrUpdateMonomerCollection(n,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${n}" saved successfully`),await this.refreshView()}catch(e){o.shell.error("Error saving collection")}}).show({resizable:!0}).root.style.width="550px",c.focus()}async deleteCollection(e){r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete "${e.displayName}"?`)).onOK(async()=>{try{const t=await bn.getInstance();await t.deleteMonomerCollection(e.name),o.shell.info(`Collection "${e.displayName}" deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collection")}}).show()}async duplicateCollection(e){const t=r.input.string("New Name",{value:`${e.displayName} (copy)`,nullable:!1});r.dialog({title:"Duplicate Collection"}).add(t).onOK(async()=>{const n=t.value?.trim();if(n)try{const t=await bn.getInstance();await t.addOrUpdateMonomerCollection(n,[...e.data.monomerSymbols],e.data.description,e.data.tags?[...e.data.tags]:void 0),o.shell.info(`Collection "${n}" created`),await this.refreshView()}catch(e){o.shell.error("Error duplicating collection")}else o.shell.warning("Name is required")}).show()}async mergeCollections(e){const t=r.input.string("Merged Name",{value:"Merged Collection",nullable:!1}),n=r.input.string("Description",{nullable:!0,placeholder:"Optional description"});r.dialog({title:`Merge ${e.length} Collections`}).add(r.divV([r.divText(`Merging: ${e.map(e=>e.displayName).join(", ")}`),t,n])).onOK(async()=>{const i=t.value?.trim();if(i)try{const t=[...new Set(e.flatMap(e=>e.data.monomerSymbols))],r=[...new Set(e.flatMap(e=>e.data.tags??[]))],s=await bn.getInstance();await s.addOrUpdateMonomerCollection(i,t,n.value??void 0,r.length>0?r:void 0),o.shell.info(`Merged collection "${i}" created with ${t.length} monomers`),await this.refreshView()}catch(e){o.shell.error("Error merging collections")}else o.shell.warning("Name is required")}).show()}async deleteMultipleCollections(e){r.dialog({title:"Delete Collections"}).add(r.divText(`Are you sure you want to delete ${e.length} collections?\n${e.map(e=>e.displayName).join(", ")}`)).onOK(async()=>{try{const t=await bn.getInstance();for(const n of e)await t.deleteMonomerCollection(n.name);o.shell.info(`${e.length} collections deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collections")}}).show()}async refreshView(){const e=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(e&&e._mcView){const t=e._mcView;await t.refresh()}}parseTags(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}getMonomerLib(){return As.monomerLib??null}static getMonomerTooltipSafe(e,t){const n=[Be.o.AA,Be.o.NUCLEOTIDE,Be.o.CHEM,Be.o.BLOB];for(const i of n)try{if(e.getWebEditorMonomer(i,t))return e.getTooltip(i,t)}catch{}return null}static disableButton(e){e.style.opacity="0.4",e.style.cursor="default"}static buildContextMenu(e,t,n){const i=s.User.current().login,o=t.data.updatedBy===i;e.item("Edit",()=>{o&&n.editCollection(t)},null,{isEnabled:()=>o?null:"Only the author can edit"}),e.item("Delete",()=>{o&&n.deleteCollection(t)},null,{isEnabled:()=>o?null:"Only the author can delete"}),e.item("Duplicate",()=>n.duplicateCollection(t))}static buildMultiContextMenu(e,t,n){const i=s.User.current().login,o=t.every(e=>e.data.updatedBy===i);e.item("Merge",()=>n.mergeCollections(t)),e.item("Delete All",()=>{o&&n.deleteMultipleCollections(t)},null,{isEnabled:()=>o?null:"Only the author can delete (you must be author of all)"})}}var Yn=n(1757),Kn=n.n(Yn);class Zn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Xn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Zn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Jn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Jn._instance||(Jn._instance=new Jn,await Jn._instance.refresh(),(await bn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Jn._instance.refresh())),Jn._instance.refresh(),Jn._instance}async refresh(){this.settings=await(0,Le.u)();const e=await bn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Xn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Le.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Le.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Qn=n(3017),ei={};async function ti(){await si.showDialog()}async function ni(e=!0){return await ai.showView(e)}ei.styleTagTransform=C(),ei.setAttributes=y(),ei.insert=g().bind(null,"head"),ei.domAPI=m(),ei.insertStyleElement=v(),h()(Qn.A,ei),Qn.A&&Qn.A.locals&&Qn.A.locals;class ii{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==ii.instancePromise&&(ii.instancePromise=(async()=>{const e=new ii,t=await(0,ye.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),ii.instancePromise}static async reloadWidget(){const e=await ii.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,ye.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await oi.createControlsForm();return Kn()(e).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),setTimeout(()=>{e&&Kn()(e)&&Kn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class oi{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){As.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Le.u)(),t=await(0,ye.pj)();return new oi(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Kn()(t).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),t}async updateControlsForm(){const e=await this._createControlsForm();Kn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;As.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{ri(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=r.icons.edit(async()=>{o.shell.v=await(await Ln.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),As.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await ri(!1,e);const n=await(0,ye.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function ri(e,t){const n=await(0,Le.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Le.E)(n);const i=await(0,ye.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class si{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){si._instance||(si._instance=new si,si._instance.closeDialogSubject$.subscribe(()=>{si._instance.dialog=void 0})),si._instance.dialog||(si._instance.dialog=await si._instance.getDialog()),si._instance.dialog.show()}async getDialog(){const e=(await ii.getInstance()).widget,t=await(0,ye.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Kn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class ai{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await ii.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=ai.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=ai._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return ai._instance||(ai._instance=new ai),ai._instance._duplicateManager||(ai._instance._duplicateManager=await Jn.getInstance()),ai._instance.libManager||(ai._instance.libManager=await bn.getInstance()),e&&ai._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===ai._instance._view.id)?(o.shell.v=ai._instance._view,await ai._instance._duplicateManager.refresh(),ai._instance._view):(ai.closeExistingViews(),ai._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===ai.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await bn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Le.u)();i.exclude=l,await(0,Le.E)(i),await this.libManager.loadMonomerLib(!0),await ii.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var li,ci=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ui{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>ci(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>ci(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>ci(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>ci(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,ui.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return ci(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield s.delay(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep===this.stepNumber)return this._restartBtn.disabled=!1,void(this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn));if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))})}_startScript(){return ci(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return ci(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return ci(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return ci(this,void 0,void 0,function*(){this._restartBtn.disabled=!0,o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ui.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return ci(this,void 0,void 0,function*(){var e;(null===(e=o.shell.v)||void 0===e?void 0:e.name)===this.name&&o.shell.v.close(),this._initRoot(),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ui.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(li||(li={}));var hi=n(966),di=n(608),mi=n(1619),pi=n(8152);class gi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${As.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case tt.n5.fixWidth:case tt.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var yi=n(6869);const bi="-";class vi extends Ge{constructor(e,t){super(e,t)}static _canonLoadingKey=pe.sc+".loading";getCanonicalizer(e){const t=e.temp[pe.sc]??null;if(t)return t;if(e.temp[vi._canonLoadingKey])return null;const n=e.getTag(pe.jz);if(!n)return null;const i=n.includes(":")?n.split(":"):[void 0,n],o=s.Func.find({name:i[1],package:i[0]});return 0===o.length||(e.temp[vi._canonLoadingKey]=!0,o[0].apply({}).then(t=>{e.temp[pe.sc]=t,e.temp[vi._canonLoadingKey]=!1,this.gridCol?.grid?.invalidate&&this.gridCol.grid.invalidate()}).catch(()=>{e.temp[vi._canonLoadingKey]=!1})),null}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";const a=e.measureText("M"),l=a.actualBoundingBoxAscent+a.actualBoundingBoxDescent+8;let c=r.cell.value;c&&c!==pe._S||(c=bi);const u=c.split(pe.ot).map(e=>e&&e!==pe._S?e.trim():bi),h=u.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/u.length)))),d=h.map(t=>e.measureText(t).width+4),m=d.reduce((e,t)=>e+t,0);let p=t+(i-m)/2+2;const g=this.tableCol.getTag(pe.gp.alphabet),f=g===ue.YI.RNA||g===ue.YI.DNA?yi.o.NUCLEOTIDE:yi.o.AA;for(let a=0;a<h.length;a++){const c=u[a],m=this.getHelmType(r,f);let g=$e.S$,y="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,c);g=e?.textcolor??g,y=e?.backgroundcolor??y}else g=this.monomerLib.getMonomerTextColor(m,c);if(s)if(e.fillStyle=y,i<30||o<30)e.fillRect(t+a*i/h.length,n,i/h.length,o);else{const t=2;e.roundRect(p-2,n+o/2-l/2,d[a],l,t),e.fill()}e.fillStyle=g,e.fillText(h[a],p,n+o/2,i),p+=d[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,He.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(pe.gp.alphabet),a=e.cell.value,l=this.getCanonicalizer(i),c=l&&a?l.canonicalize(a):a,u=e.grid.canvas.getBoundingClientRect(),h=e.bounds.right+u.left-4,d=e.bounds.bottom+u.top-4;if(!a||a==pe._S||a==bi||null!=l&&l.isGap(a))return r.tooltip.show(r.divText("gap"),h,d),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),h,d),!0;const m=s===ue.YI.RNA||s===ue.YI.DNA?yi.o.NUCLEOTIDE:yi.o.AA,p=c.split(pe.ot).map(t=>{if(!t||t===pe._S||t===bi)return r.divText("gap");const n=this.getHelmType(e,m);return this.monomerLib.getTooltip(n,t)}),g=r.divH(p,{style:{alignItems:"top",flexWrap:"wrap",gap:"4px"}}),f=Array.from(g.querySelectorAll("canvas"));if(f.length>2){const e=Math.floor(550/f.length);f.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(g,h,d),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,He.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(pe.qE.polymerTypeColumnName)){const t=o.getTag(pe.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,Oe.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new vi(t,n)),o}}class wi extends s.GridCellRenderer{get name(){return Ve.uF.MONOMER}get cellType(){return Ve.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){vi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){vi.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class Ci{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class Ai extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class Si extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new Ci(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ve.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var xi=n(6307),Ei=n(5999),Mi={};Mi.styleTagTransform=C(),Mi.setAttributes=y(),Mi.insert=g().bind(null,"head"),Mi.domAPI=m(),Mi.insertStyleElement=v(),h()(Ei.A,Mi),Ei.A&&Ei.A.locals&&Ei.A.locals;class Ti extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=As.properties.tooltipWebLogo,n=this.seqCol.getTag(Je.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}var Ii=n(4951);function Li(e,t,n,i){const o=As.seqHelper.getSeqHandler(e);let r=null,a=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(a=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==a&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<a)throw new Error(`End position ${a} exceeds positions length`);const l=i||`${e.name}: (${t??""}-${n??""})`,c=function(e,t,n,i,o){if(!n||!i||!e.dataFrame)return null;const r=e.getTag(ue.gp.annotations);if(!r)return null;let a;try{a=JSON.parse(r)}catch{return null}const l=a.find(e=>e.category===Et.eI.Structure&&e.start===n&&e.end===i);if(!l)return null;const c=(0,xt.VT)(e.name);let u=null;try{u=e.dataFrame.columns.byName(c)}catch{return null}if(!u)return null;const h=(0,xt.wi)(u);if(!h.some(e=>e?.some(e=>e.annotationId===l.id&&null!=e.endPositionIndex)))return null;const d=e.dataFrame,m=s.Column.fromType(s.COLUMN_TYPE.STRING,o,d.rowCount);for(let e=0;e<d.rowCount;e++){const n=h[e],i=n?.find(e=>e.annotationId===l.id&&null!=e.endPositionIndex);if(i){const n=t.getSplitted(e),o=[];for(let e=i.positionIndex;e<=i.endPositionIndex;e++)e<n.length&&o.push(n.getOriginal(e));m.set(e,o.join(t.separator||""))}else m.set(e,"")}return m}(e,o,t,n,l);return c||o.getRegion(r,a,l)}const _i={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Ni{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??_i;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${As.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Pi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value;let t=null;const n=e?e.getTag(ue.gp.annotations):null;if(n)try{const e=JSON.parse(n).filter(e=>"structure"===e.category&&e.start&&e.end);e.length>0&&(t=e.map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end})))}catch{}if(!t){const n=e?e.getTag(ue.gp.regions):null;t=n?JSON.parse(n):null}const i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=t){this.inputs.region.root.style.removeProperty("display");for(const e of t){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{As.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{As.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var Ri=n(8754);async function $i(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=ge(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):pe._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=ge(e,n).columns.toList());const i=(await(0,ye.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):pe._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==pe._S&&t!==p?l[e]+=y[t]:c===pe._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null==u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Oi=n(294),ki=n(330);const Hi=OCL;var Bi=n(2582);class Fi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var Di=n(6956);class Gi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===Di.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=Ot.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const v=new Map;v.set(p+1,e+1);let w=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),v.set(e+1,w),w++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=v.get(t),o=v.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Vi{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class qi extends Vi{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class ji{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ui extends ji{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Wi extends Fi{constructor(e,t){super(t);const n=Ot.getInstance(e);this.atoms=new qi(n),this.bonds=new Ui(n),this.rGroups=new Gi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class zi extends Vi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Yi extends ji{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Ki extends Fi{constructor(e,t){super(t);const n=Ot.getInstance(e);this.atoms=new zi(n),this.bonds=new Yi(n),this.rGroups=new Gi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Zi{static getInstance(e,t){if(Ot.isMolfileV2K(e))return new Wi(e,t);if(Ot.isMolfileV3K(e))return new Ki(e,t);throw new Error("Unsupported molfile version")}}class Xi{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Ot.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Zi.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Xi.molfileV2KToV3KCache.has(e))return Xi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Xi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ji{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Bi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===pe.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Xi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Oi.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Be.o.NUCLEOTIDE:Be.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Qi{constructor(e){this.molfileHandler=Ot.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class eo{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Hi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,ve.AP)(e);return As.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,ki.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Oi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,ve.AP)(e);As.logger.error(t,void 0,n),o=Oi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Qi(o),s=new Ji(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Oi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Oi.vF(a.molfile,l)}}var to=n(2738);class no{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[me.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}runInnerDetector(){if(!this._column.temp.seqHandlerDetectorRun){this._column.temp.seqHandlerDetectorRun=!0;const e=s.Func.find({name:"detectMacromolecule",meta:{role:"semTypeDetector"}})[0];e&&e.applySync({col:this._column})}}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;let n=this._column.meta.units;if(!n&&(this.runInnerDetector(),n=this._column.meta.units,!n))throw new Error("Units are not specified in column");if(this._units=n,this._notation=this.getNotation(),[ue.Hi.BILN,ue.Hi.CUSTOM,ue.Hi.SEPARATOR].includes(this._notation)&&!this.column.getTag(ue.gp.separator)&&(this.runInnerDetector(),!this.column.getTag(ue.gp.separator)))throw new Error(`Separator tag '${ue.gp.separator}' is not set for notation '${this._notation}'.`);(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[me.j.notationProvider]??null);const i=this.isFasta()?pe.b9[ue.Hi.FASTA]:this.isSeparator()?pe.b9[ue.Hi.SEPARATOR]:this.isHelm()?pe.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??pe.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[me.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.BILN].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength||e.column.categories.slice(0,5).filter(e=>!!e).every(e=>e.length>100)?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,Oe.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new to.aD(e.name,e.alphabet,.9));t=(0,Oe.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?Be.o.NUCLEOTIDE:Be.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===pe.b9[ue.Hi.FASTA]?pe._S:i??pe._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(pe._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===pe.b9[ue.Hi.FASTA]?pe._S:o??pe._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new me.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!no.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:Oe.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?pe.b9[ue.Hi.FASTA]:pe.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===pe.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=pe.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new Oe.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return io(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return oo(n,t,e)};break}case ue.Hi.BILN:i=function(e){return ro(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[me.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[me.j.seqHandler]=new no(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return io(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return oo(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:ro(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new Oe.Mu(n.filter(e=>!!e),pe.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function io(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function oo(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===pe._S?r=pe.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===pe._S?s=pe.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function ro(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class so{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return no.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Ht.b2)();return new eo(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Oi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Oi.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Oi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Oi.vF(e,o.monomers)}catch(e){const[t,n]=(0,ve.AP)(e);return As.logger.error(t,void 0,n),Oi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,ki.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,no.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),no.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,no.setTags(e)}}async function ao(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await xs.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[me.j.notationProvider]&&(i.temp[me.j.notationProvider]=e.cell.column.temp[me.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await xs.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){As.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const lo="#333333",co="rgba(60, 177, 115, 0.1)",uo="rgba(240, 240, 240, 0.5)",ho="rgba(100, 100, 100, 0.3)";class mo{constructor(e=fo.DEFAULT_TRACK_HEIGHT,t=fo.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class po extends mo{constructor(e=new Map,t=fo.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,fo.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Be.o.NUCLEOTIDE;break;default:t=Be.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,xi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=co,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=uo,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=ho,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class go extends mo{constructor(e,t=fo.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,fo.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=co,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=uo,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=ho,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=lo,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const fo={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35,ANNOTATION_TRACK_HEIGHT:20},yo={BASE:fo.DOTTED_CELL_HEIGHT+fo.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+fo.TITLE_HEIGHT+fo.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+fo.DEFAULT_TRACK_HEIGHT+fo.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+fo.DEFAULT_TRACK_HEIGHT+fo.TRACK_GAP}};class bo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||yo.BASE,sliderHeight:e.sliderHeight||fo.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0,dragMode:"none",dragStartWindowPosition:1,dragOccurred:!1},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation"),i=this.getTrack("annotations");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(fo.DEFAULT_TRACK_HEIGHT)}),e<yo.WITH_TITLE())return;let o=0;i&&(i.setVisible(!0),i.setHeight(fo.ANNOTATION_TRACK_HEIGHT),o=fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP);const r=yo.WITH_WEBLOGO()+o,s=yo.WITH_BOTH()+o;if(!(e<r))if(e<s){if(t){t.setVisible(!0);const n=e-r;t.setHeight(fo.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>s){const n=e-s;t.setHeight(fo.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<r&&t&&t.setVisible(!1),e<s&&n&&n.setVisible(!1))}}drawTrackButtons(){const e=70;if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),n=this.getTrack("weblogo"),i=this.getTrack("annotations"),o=t?.isVisible()??!1,r=n?.isVisible()??!1,s=i?.isVisible()??!1;let a=this.config.width-16;const l=this.config.headerHeight>=yo.WITH_TITLE()?(fo.TITLE_HEIGHT-14)/2:2;o&&r||(!o&&t&&(a-=e,this.drawTrackButton("conservation","Conservation",a,l,e,14),a-=4),!r&&n&&(a-=e,this.drawTrackButton("weblogo","WebLogo",a,l,e,14),a-=4)),!s&&i&&(a-=e,this.drawTrackButton("annotations","Annotations",a,l,e,14))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0)}snapToTrackHeight(e){const t=this.getTrack("annotations")?fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP:0;let n;if("annotations"===e)n=yo.WITH_TITLE()+t;else if("weblogo"===e)n=yo.WITH_WEBLOGO()+t;else{if("conservation"!==e)return;n=yo.WITH_BOTH()+t}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]="annotations"===t})),"annotations"===e?this.userSelectedTracks.annotations=!0:"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(n),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.getTrack("annotations")?fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP:0,t=this.tracks.size>0?yo.WITH_BOTH()+e:yo.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=yo.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,fo.TITLE_HEIGHT),this.ctx.fillStyle=lo,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+fo.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof po&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0,l=this.config.headerHeight-fo.SLIDER_HEIGHT-fo.DOTTED_CELL_HEIGHT,c=l-fo.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[];this.tracks.forEach((e,t)=>{e.isVisible()&&d.push({id:t,track:e})});let m=c;for(const{id:e,track:t}of d){const i=m-t.getHeight();if(n>=i&&n<m){u=e,h=n-i;break}m=i-fo.TRACK_GAP}let p=null;if(u){const e=this.tracks.get(u);e&&(p=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==p)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=p,u)){const e=this.tracks.get(u);e instanceof po&&(e.setHovered(s,p),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||p!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=p,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,p);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=yo.WITH_TITLE();l&&fo.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-fo.SLIDER_HEIGHT,u=c-fo.DOTTED_CELL_HEIGHT,h=u-fo.TRACK_GAP,d=[],m=[];this.tracks.forEach((e,t)=>{e.isVisible()&&m.push({id:t,track:e})});let p=h;for(const{track:e}of m){const t=e.getHeight(),i=p-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),p=i-fo.TRACK_GAP}if(this.drawDottedCells(0,u,n,fo.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:fo.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+fo.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=lo,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,fo.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,fo.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,fo.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-fo.SLIDER_HEIGHT;return t>n&&t<n+fo.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-fo.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+fo.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.state.isDragging&&"header"===this.state.dragMode?this.eventElement.style.cursor="grabbing":this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)?this.eventElement.style.cursor="pointer":this.isInHeaderArea(e)?this.eventElement.style.cursor="grab":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(this.state.dragOccurred)return;if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0,a=this.config.headerHeight-fo.SLIDER_HEIGHT-fo.DOTTED_CELL_HEIGHT,l=a-fo.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-fo.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=yo.WITH_TITLE()&&t&&(vo(e.left??0,n,i)||vo(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e);this.isInSliderDraggableArea(e)?(this.state.isDragging=!0,this.state.dragMode="slider",this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()):this.isInHeaderArea(e)&&!this.isInSliderArea(e)&&(this.state.isDragging=!0,this.state.dragMode="header",this.state.dragStartX=t,this.state.dragStartWindowPosition=this.config.windowStartPosition,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;if(this.state.dragOccurred=!0,"slider"===this.state.dragMode)this.handleSliderDrag(n);else if("header"===this.state.dragMode){const e=n-this.state.dragStartX,t=Math.round(e/this.config.positionWidth),i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-i+1;this.config.windowStartPosition=Math.max(1,Math.min(o,this.state.dragStartWindowPosition-t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1,this.state.dragMode="none",this.state.dragOccurred&&setTimeout(()=>{this.state.dragOccurred=!1},0)}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(this.state.dragOccurred)return;if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(this.isInsideColumnHeaderArea(t,n))this.seqColumn&&(o.shell.o=this.seqColumn);else if(n<this.config.headerHeight-fo.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:yo.BASE,WITH_TITLE:yo.WITH_TITLE(),WITH_WEBLOGO:yo.WITH_WEBLOGO(),WITH_BOTH:yo.WITH_BOTH()}}}function vo(e,t,n){return e>=t&&e<=n}class wo extends mo{constructor(e,t="Annotations"){super(20,14,t),this.tableCol=e,this.regions=[],this.posList=[],this._cacheVersion=-1,this._rebuildRegions()}hasRegions(){return this._ensureUpToDate(),this.regions.length>0}getRegionAtPosition(e){this._ensureUpToDate();for(const t of this.regions)if(e>=t.startIdx&&e<=t.endIdx)return t;return null}getTooltipContent(e,t){this._ensureUpToDate();const n=this.getRegionAtPosition(e);if(!n)return null;const i=n.sourceScheme??"",o=e<this.posList.length?this.posList[e]:"",s=[],a=document.createElement("b");return a.textContent=n.name,s.push(r.div([a],{style:{fontSize:"13px",marginBottom:"4px"}})),i&&s.push(r.divText(`Scheme: ${i}`,{style:{fontSize:"12px",color:"#555"}})),s.push(r.divText(`Range: ${n.startPos} – ${n.endPos}`,{style:{fontSize:"12px",color:"#555"}})),o&&s.push(r.divText(`Position: ${o}`,{style:{fontSize:"12px",color:"#555"}})),n.description&&s.push(r.divText(n.description,{style:{fontSize:"11px",color:"#888",marginTop:"2px"}})),r.divV(s,{style:{padding:"4px"}})}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible)return;if(this._ensureUpToDate(),0===this.regions.length)return;const l=this.ctx;l.save(),l.beginPath(),l.rect(e,t,n,i),l.clip();const c=o-1,u=c+Math.ceil(n/r)+2;for(const n of this.regions){if(n.endIdx<c||n.startIdx>u)continue;const o=Math.max(n.startIdx,c),s=e+(o-c)*r,a=(Math.min(n.endIdx,u)-o+1)*r;l.fillStyle=n.color,l.globalAlpha=.35,l.fillRect(s,t,a,i),l.globalAlpha=1,l.strokeStyle=n.color,l.globalAlpha=.6,l.lineWidth=1,l.strokeRect(s+.5,t+.5,a-1,i-1),l.globalAlpha=1,l.font="bold 9px Roboto, Roboto Local, sans-serif",a>l.measureText(n.name).width+4&&(l.fillStyle="#333",l.textAlign="center",l.textBaseline="middle",l.fillText(n.name,s+a/2,t+i/2))}l.restore()}_ensureUpToDate(){this._cacheVersion!==this.tableCol.version&&(this._rebuildRegions(),this._cacheVersion=this.tableCol.version)}_rebuildRegions(){this.regions=[];const e=this.tableCol.getTag(pe.gp.annotations);if(!e)return;let t;try{t=JSON.parse(e)}catch{return}if(this.posList=this._getPosList(),0!==this.posList.length)for(const e of t){if(e.category!==Et.eI.Structure)continue;if(null==e.start||null==e.end)continue;const t=this.posList.indexOf(e.start),n=this.posList.indexOf(e.end);t<0||n<0||this.regions.push({name:e.name,color:e.color??this._defaultColor(e),startIdx:t,endIdx:n,startPos:e.start,endPos:e.end,sourceScheme:e.sourceScheme,description:e.description})}}_getPosList(){const e=this.tableCol.getTag(pe.gp.positionNames);return e?e.split(", "):[]}_defaultColor(e){if(e.name.startsWith("CDR")){const t=parseInt(e.name.replace("CDR",""))-1;return Et.D5.structure.CDR[t%Et.D5.structure.CDR.length]}if(e.name.startsWith("FR")){const t=parseInt(e.name.replace("FR",""))-1;return Et.D5.structure.FR[t%Et.D5.structure.FR.length]}return"#90CAF9"}}class Co{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){Co.conservationCache=new s.LruCache(100),Co.webLogoCache=new s.LruCache(100),Co.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return Co.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return Co.conservationCache.getOrCreate(i,()=>{const o=Co.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return Co.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/Co.CHUNK_SIZE)*Co.CHUNK_SIZE,s=Math.ceil(n/Co.CHUNK_SIZE)*Co.CHUNK_SIZE;for(let t=r;t<s;t+=Co.CHUNK_SIZE){const n=Math.min(t+Co.CHUNK_SIZE,i),r=Co.getChunkCacheKey(e.column,t,n),s=Co.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/Co.CHUNK_SIZE)*Co.CHUNK_SIZE,s=Math.ceil(n/Co.CHUNK_SIZE)*Co.CHUNK_SIZE;for(let t=r;t<s;t+=Co.CHUNK_SIZE){const n=Math.min(t+Co.CHUNK_SIZE,i),r=Co.getChunkCacheKey(e.column,t,n),s=Co.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class Ao extends po{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=Co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=Co.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class So extends go{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=Co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=Co.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const xo="__msa-scroller-initialized",Eo="__msa-scroller-subscription";class Mo extends to.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return pe.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=Oe.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:pe.Hi.HELM})(n)}createCellRendererBack(e,t){const n=As.properties.maxMonomerLength||4,i=new To(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class To extends $e.Jy{constructor(e,t,n,i){super(e,t,As.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=$e.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:Oe.zS}})}}var Io,Lo,_o=n(6520),No={};No.styleTagTransform=C(),No.setAttributes=y(),No.insert=g().bind(null,"head"),No.domAPI=m(),No.insertStyleElement=v(),h()(_o.A,No),_o.A&&_o.A.locals&&_o.A.locals;class Po{view=null;libHelper=null;monomerLib=null;collectionNames=[];filteredNames=[];displayedCount=0;cardsContainer=null;loadMoreContainer=null;searchInput=null;currentUser="";collectionsCache=new Map;selectedCollections=new Set;cardElements=new Map;handler=new zn;static VIEW_NAME="Monomer Collections";async init(){this.libHelper=await bn.getInstance(),await this.libHelper.awaitLoaded(),this.monomerLib=this.libHelper.getMonomerLib(),this.currentUser=s.User.current().login,this.view=s.View.create(),this.view.name=Po.VIEW_NAME,this.view._mcView=this;const e=r.icons.add(()=>this.showAddCollectionDialog(),"Create new monomer collection"),t=r.iconFA("sync",()=>this.refresh(),"Refresh collections");return this.view.setRibbonPanels([[e,t]]),this.view.root.addEventListener("contextmenu",e=>{const t=e.target;if(t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card"))return;e.preventDefault();const n=s.Menu.popup();n.item("New Collection...",()=>this.showAddCollectionDialog()),n.item("Refresh",()=>this.refresh()),n.show()}),this.view.root.addEventListener("click",e=>{const t=e.target;t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card")||this.clearSelection()}),this.view.root.tabIndex=0,this.view.root.addEventListener("keydown",e=>{"Escape"===e.key&&this.clearSelection()}),await this.buildContent(),this.view}async buildContent(){if(!this.view)return;this.view.root.innerHTML="";const e=r.div([],{classes:"monomer-collections-view"});this.searchInput=r.input.string("Monomer Collections",{value:"",placeholder:"Search by name or tag..."}),this.searchInput.root.classList.add("monomer-collections-search");const t=this.searchInput.input;t.style.width="100%",t.style.marginBottom="12px";let n=null;t.addEventListener("input",()=>{n&&clearTimeout(n),n=setTimeout(()=>this.applyFilter(),250)}),this.cardsContainer=r.div([],{classes:"monomer-collections-grid"}),this.loadMoreContainer=r.div([],{classes:"monomer-collections-load-more"}),e.appendChild(this.searchInput.root),e.appendChild(this.cardsContainer),e.appendChild(this.loadMoreContainer),this.view.root.appendChild(e),await this.loadCollections()}async loadCollections(){try{this.collectionNames=await this.libHelper.listMonomerCollections()}catch(e){As.logger.error(`Error listing monomer collections: ${e instanceof Error?e.message:e.toString()}`),o.shell.error("Error loading monomer collections"),this.collectionNames=[]}this.collectionsCache.clear();for(const e of this.collectionNames)this.libHelper.readMonomerCollection(e).then(t=>{this.collectionsCache.set(e,t)}).catch(()=>{});this.applyFilter()}applyFilter(){const e=(this.searchInput?.value??"").trim().toLowerCase();this.filteredNames=e?this.collectionNames.filter(t=>{if(t.replace(/\.json$/i,"").toLowerCase().includes(e))return!0;const n=this.collectionsCache.get(t);return!!n?.tags?.some(t=>t.toLowerCase().includes(e))}):[...this.collectionNames],this.displayedCount=0,this.cardsContainer.innerHTML="",this.cardElements.clear(),this.showNextPage()}showNextPage(){const e=Math.min(this.displayedCount+19,this.filteredNames.length);for(let t=this.displayedCount;t<e;t++){const e=this.createCollectionCard(this.filteredNames[t]);this.cardsContainer.appendChild(e),this.cardElements.set(this.filteredNames[t],e)}this.displayedCount=e;const t=this.cardsContainer.querySelector(".monomer-collection-add-card");t&&t.remove(),this.cardsContainer.appendChild(this.createAddCard());const n=this.cardsContainer.querySelector(".monomer-collection-empty-state");if(n&&n.remove(),0===this.filteredNames.length){const e=0===this.collectionNames.length?'No monomer collections found. Click "+" to create one.':"No collections match your search.",t=r.div([r.divText(e)],{classes:"monomer-collection-empty-state"});this.cardsContainer.prepend(t)}if(this.loadMoreContainer.innerHTML="",this.displayedCount<this.filteredNames.length){const e=this.filteredNames.length-this.displayedCount,t=r.button(`Load more (${e} remaining)`,()=>this.showNextPage());this.loadMoreContainer.appendChild(t)}}createCollectionCard(e){const t=e.replace(/\.json$/i,""),n=r.div([t],{classes:"monomer-collection-card-title"});r.tooltip.bind(n,t);const i=r.div([n],{classes:"monomer-collection-card-header"}),a=r.div([],{classes:"monomer-collection-card-body"}),l=r.div([],{classes:"monomer-collection-card-actions"}),c=r.div([i,a,l],{classes:"monomer-collection-card"});c.dataset.collectionName=e,this.selectedCollections.has(e)&&c.classList.add("monomer-collection-card-selected"),c.addEventListener("click",t=>{const n=t.target;n.closest(".monomer-collection-card-actions")||n.closest(".monomer-collection-tag")||(t.stopPropagation(),this.handleCardClick(e,t.ctrlKey||t.metaKey))}),c.addEventListener("contextmenu",t=>{t.preventDefault(),t.stopPropagation(),this.selectedCollections.has(e)||this.handleCardClick(e,!1),this.showCardContextMenu(t)});const u=async()=>{const t=await this.libHelper.readMonomerCollection(e);if(this.collectionsCache.set(e,t),t.description){const e=r.div([t.description],{classes:"monomer-collection-card-description"});r.tooltip.bind(e,t.description),i.appendChild(e)}if(t.tags&&t.tags.length>0){const e=r.div([],{classes:"monomer-collection-card-tags"});for(const n of t.tags){const t=r.div([n],{classes:"monomer-collection-card-tag"});e.appendChild(t)}i.appendChild(e)}const n=[];if(t.updatedBy&&n.push(`by ${t.updatedBy}`),t.updatedOn)try{n.push(new Date(t.updatedOn).toLocaleDateString())}catch{}n.length>0&&i.appendChild(r.div([n.join(" | ")],{classes:"monomer-collection-card-meta"}));const a=r.div([],{classes:"monomer-collection-tags"}),c=t.monomerSymbols??[];for(const e of c){const t=r.div([e],{classes:"monomer-collection-tag"});t.addEventListener("mouseenter",()=>{if(this.monomerLib){const n=this.getMonomerTooltipSafe(e);if(n){const e=t.getBoundingClientRect();r.tooltip.show(n,e.left,e.bottom+4)}}}),t.addEventListener("mouseleave",()=>r.tooltip.hide()),t.addEventListener("click",t=>{t.stopPropagation(),o.shell.o=s.SemanticValue.fromValueType(e,Ve.uF.MONOMER)}),a.appendChild(t)}const u=r.divText(`${c.length} monomer(s)`,{style:{fontSize:"11px",color:"var(--grey-4)",marginBottom:"6px"}}),h=r.divV([u,a]),d=t.updatedBy===this.currentUser,m=r.button("Edit",()=>{d&&this.showEditCollectionDialog(e,t)}),p=r.button("Delete",()=>{d&&this.confirmDeleteCollection(e)});if(!d){for(const e of[m,p])e.style.opacity="0.4",e.style.cursor="default";r.tooltip.bind(m,"Only the author can edit"),r.tooltip.bind(p,"Only the author can delete")}return l.appendChild(m),l.appendChild(p),h};return a.appendChild(r.wait(()=>u())),c}handleCardClick(e,t){t?this.selectedCollections.has(e)?this.selectedCollections.delete(e):this.selectedCollections.add(e):(this.selectedCollections.clear(),this.selectedCollections.add(e)),this.updateCardSelectionStyles(),this.setCurrentObject()}clearSelection(){this.selectedCollections.clear(),this.updateCardSelectionStyles()}updateCardSelectionStyles(){for(const[e,t]of this.cardElements)this.selectedCollections.has(e)?t.classList.add("monomer-collection-card-selected"):t.classList.remove("monomer-collection-card-selected")}async setCurrentObject(){const e=[...this.selectedCollections];if(0===e.length)return;const t=[];for(const n of e){let e=this.collectionsCache.get(n);if(!e)try{e=await this.libHelper.readMonomerCollection(n)}catch{continue}t.push({name:n,displayName:n.replace(/\.json$/i,""),data:e})}1===t.length?o.shell.o=t[0]:t.length>1&&(o.shell.o=t)}showCardContextMenu(e){const t=s.Menu.popup(),n=[...this.selectedCollections];if(n.length<=1&&n.length>0){const e=n[0],i=this.collectionsCache.get(e);if(i){const n={name:e,displayName:e.replace(/\.json$/i,""),data:i};zn.buildContextMenu(t,n,this.handler)}}else if(n.length>1){const e=n.map(e=>{const t=this.collectionsCache.get(e);return t?{name:e,displayName:e.replace(/\.json$/i,""),data:t}:null}).filter(e=>null!==e);e.length>0&&zn.buildMultiContextMenu(t,e,this.handler)}t.show()}getMonomerTooltipSafe(e){if(!this.monomerLib)return null;const t=[Be.o.AA,Be.o.NUCLEOTIDE,Be.o.CHEM,Be.o.BLOB];for(const n of t)try{if(this.monomerLib.getWebEditorMonomer(n,e))return this.monomerLib.getTooltip(n,e)}catch(e){}return null}createAddCard(){const e=r.iconFA("plus",()=>{},"");e.style.fontSize="32px",e.style.marginBottom="8px";const t=r.span(["New Collection"]),n=r.div([e,t],{classes:"monomer-collection-add-card-content"}),i=r.div([n],{classes:"monomer-collection-add-card"});return i.addEventListener("click",()=>this.showAddCollectionDialog()),i}showAddCollectionDialog(){const e=r.input.string("Name",{nullable:!1,placeholder:"Enter collection name"}),t=r.input.string("Description",{nullable:!0,placeholder:"Optional description"}),n=r.input.string("Tags",{nullable:!0,placeholder:"Comma-separated tags"}),i=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),s=new Wn(this.monomerLib,i.value,[],this.libHelper);i.onChanged.subscribe(()=>{s.setPolymerType(i.value)}),r.dialog({title:"New Monomer Collection"}).add(r.divV([e,t,n,i,r.element("hr"),s.root])).onOK(async()=>{const i=e.value?.trim();if(!i)return void o.shell.warning("Collection name is required");const r=s.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const a=Ro(n.value);try{await this.libHelper.addOrUpdateMonomerCollection(i,r,t.value??void 0,a.length>0?a:void 0),o.shell.info(`Collection "${i}" created successfully`),await this.refresh()}catch(e){o.shell.error("Error creating collection"),As.logger.error(`Error creating collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",s.focus()}editCollectionPublic(e,t){this.showEditCollectionDialog(e,t)}showEditCollectionDialog(e,t){const n=e.replace(/\.json$/i,""),i=r.input.string("Name",{value:n,nullable:!1}),s=r.input.string("Description",{value:t.description??"",nullable:!0}),a=r.input.string("Tags",{value:(t.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(this.monomerLib,l.value,[...t.monomerSymbols??[]],this.libHelper);l.onChanged.subscribe(()=>{c.setPolymerType(l.value)}),r.dialog({title:`Edit Collection: ${n}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const t=i.value?.trim();if(!t)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=Ro(a.value);try{t!==n&&await this.libHelper.deleteMonomerCollection(e),await this.libHelper.addOrUpdateMonomerCollection(t,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${t}" saved successfully`),await this.refresh()}catch(e){o.shell.error("Error saving collection"),As.logger.error(`Error saving collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",c.focus()}confirmDeleteCollection(e){const t=e.replace(/\.json$/i,"");r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete the collection "${t}"?`)).onOK(async()=>{try{await this.libHelper.deleteMonomerCollection(e),o.shell.info(`Collection "${t}" deleted`),await this.refresh()}catch(e){o.shell.error("Error deleting collection"),As.logger.error(`Error deleting collection: ${e instanceof Error?e.message:e.toString()}`)}}).show()}async refresh(){this.selectedCollections.clear(),await this.loadCollections()}}function Ro(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}class $o{colInput;constructor(e,t){const n=t.filter;this.colInput=r.input.column(e,{...t,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE&&(!n||n(e))});const i=r.iconFA("cut",()=>this.onRegionIconClick(),"Extract a region from the sequence");this.colInput.addOptions(i)}static create(e,t){return new $o(e,t)}get root(){return this.colInput.root}get value(){return this.colInput.value}set value(e){this.colInput.value=e}get inputBase(){return this.colInput}onRegionIconClick(){const e=this.colInput.value;e?function(e,t){const n=As.seqHelper.getSeqHandler(e),i=r.input.string("Name",{value:""}),a=r.input.choice("Start Position",{value:n.posList[0],items:n.posList,onValueChanged:()=>h()}),l=r.input.choice("End Position",{value:n.posList[n.posList.length-1],items:n.posList,onValueChanged:()=>h()});let c=null;const u=()=>c?`${e.name}(${c}): ${a.value}-${l.value}`:`${e.name}:${a.value}-${l.value}`,h=()=>{i.value||i.input.setAttribute("placeholder",u())};h();const d=function(e,t,n,i){let o=null;const s=e.getTag(ue.gp.annotations);if(s)try{const e=JSON.parse(s).filter(e=>e.category===Et.eI.Structure&&e.start&&e.end);e.length>0&&(o=e.map(e=>({name:e.name,start:e.start,end:e.end})))}catch{}if(!o){const t=e.getTag(ue.gp.regions);if(t)try{o=JSON.parse(t)}catch{}}if(!o||0===o.length)return null;const a=["",...o.map(e=>`${e.name}: ${e.start}-${e.end}`)];return r.input.choice("Region",{value:"",items:a,onValueChanged:e=>{if(!e)return void i?.(null);const r=o.find(t=>`${t.name}: ${t.start}-${t.end}`===e);r&&(t.value=r.start,n.value=r.end,i?.(r.name))}})}(e,a,l,e=>{c=e,h()}),m=[];d&&m.push(d),m.push(i,a,l);const p=r.dialog({title:"Get Region"}).add(r.inputs(m)).onOK(()=>{const n=s.TaskBarProgressIndicator.create("Getting region...");try{const n=i.value||u(),o=Li(e,a.value,l.value,n);e.dataFrame.columns.add(o),o.setTag(s.TAGS.CELL_RENDERER,"sequence"),t?.(o)}catch(e){o.shell.error(e.toString())}finally{n.close()}});p.show()}(e,e=>{this.colInput.value=e}):o.shell.warning("Select a macromolecule column first.")}}async function Oo(){return await xs.getMonomerLibHelper()}async function ko(){await xs.initBio()}function Ho(e){return xs.sequenceTooltip(e)}async function Bo(e){return await xs.standardiseMonomerLibrary(e)}async function Fo(e,t,n){await xs.matchWithMonomerLibrary(e,t,n)}function Do(){return xs.getBioLib()}function Go(e){return xs.getSeqHandler(e)}function Vo(e){return xs.getRegionPanel(e)}async function qo(e){return await xs.libraryPanel(e)}function jo(e){xs.GetRegionEditor(e)}function Uo(e){xs.SplitToMonomersEditor(e)}function Wo(e){xs.SequenceSpaceEditor(e)}function zo(e){xs.SeqActivityCliffsEditor(e)}function Yo(){return xs.customSequenceCellRenderer()}function Ko(){return xs.fastaSequenceCellRenderer()}function Zo(){return xs.separatorSequenceCellRenderer()}function Xo(){return xs.bilnSequenceCellRenderer()}function Jo(e,t,n){return xs.refineNotationProviderForBiln(e,t,n)}function Qo(e){return xs.macroMolColumnPropertyPanel(e)}function er(e){return xs.compositionAnalysisWidget(e)}function tr(e){return xs.monomerInfoPanel(e)}function nr(){return xs.macromoleculeDifferenceCellRenderer()}function ir(e,t,n,i,o){return xs.sequenceAlignment(e,t,n,i,o)}function or(){return xs.webLogoViewer()}function rr(){return xs.vdRegionsViewer()}function sr(e,t,n,i){return xs.getRegion(e,t,n,i)}async function ar(e,t,n,i,o){await xs.getRegionTopMenu(e,t,n,i,o)}function lr(){xs.applyNumberingScheme()}function cr(){xs.scanLiabilities()}function ur(){xs.manageAnnotations()}function hr(e,t){return xs.sequenceColumnInput(e,t)}async function dr(e,t,n,i,o,r,s,a,l){return await xs.activityCliffs(e,t,n,i,o,r,s,a,l)}async function mr(e){await xs.seqActivityCliffsInitFunction(e)}async function pr(e,t,n,i,o,r,s,a,l){await xs.seqActivityCliffsTransform(e,t,n,i,o,r,s,a,l)}async function gr(e,t,n,i,o){return await xs.macromoleculePreprocessingFunction(e,t,n,i,o)}async function fr(e,t){return await xs.helmPreprocessingFunction(e,t)}async function yr(e,t,n,i,o,r,s,a,l){return await xs.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function br(e,t,n,i,o,r,s,a,l){return await xs.sequenceSpaceTransform(e,t,n,i,o,r,s,a,l)}async function vr(e,t){await xs.moleculesToHelmTopMenu(e,t)}async function wr(e){return await xs.moleculeToHelmSingle(e)}async function Cr(e,t,n,i){await xs.toAtomicLevel(e,t,n,i)}async function Ar(e){await xs.toAtomicLevelAction(e)}async function Sr(e){return await xs.toAtomicLevelPanel(e)}async function xr(e){return await xs.toAtomicLevelSingleSeq(e)}async function Er(e){return await xs.sequence3dStructureWidget(e)}function Mr(){xs.multipleSequenceAlignmentDialog()}async function Tr(e,t,n){return await xs.alignSequences(e,t,n)}async function Ir(e,t,n,i){return await xs.pepseaMsa(e,t,n,i)}async function Lr(){return await xs.compositionAnalysis()}function _r(e){return xs.importFasta(e)}function Nr(e){return xs.importBam(e)}function Pr(){xs.convertDialog()}function Rr(e){xs.convertColumnAction(e)}function $r(){return xs.monomerCellRenderer()}async function Or(e){return await xs.testDetectMacromolecule(e)}async function kr(e,t){return await xs.splitToMonomersTopMenu(e,t)}function Hr(e){return xs.getHelmMonomers(e)}function Br(){return xs.similaritySearchViewer()}function Fr(){return xs.similaritySearchTopMenu()}function Dr(){return xs.diversitySearchViewer()}function Gr(){return xs.diversitySearchTopMenu()}function Vr(e){xs.searchSubsequenceEditor(e)}function qr(e){xs.SubsequenceSearchTopMenu(e)}async function jr(e,t,n){return await xs.sequenceIdentityScoring(e,t,n)}async function Ur(e,t,n){return await xs.sequenceSimilarityScoring(e,t,n)}async function Wr(){await xs.manageMonomerLibraries()}async function zr(){await xs.manageLibrariesView()}async function Yr(){await xs.manageMonomersView()}async function Kr(e){return await xs.manageMonomerLibrariesView(e)}async function Zr(e){await xs.manageMonomerLibrariesViewTreeBrowser(e)}async function Xr(){return await xs.monomerCollectionsApp()}function Jr(){xs.saveAsFasta()}function Qr(){return xs.bioSubstructureFilter()}function es(){return xs.bioSubstructureFilterTest()}async function ts(){await xs.webLogoLargeApp()}async function ns(){await xs.webLogoAggApp()}async function is(){await xs.getRegionApp()}async function os(){await xs.getRegionHelmApp()}function rs(){xs.longSeqTableSeparator()}function ss(){xs.longSeqTableFasta()}function as(){xs.longSeqTableHelm()}function ls(e,t){xs.addCopyMenu(e,t)}async function cs(){await xs.demoBioSimilarityDiversity()}async function us(){await xs.demoBioSequenceSpace()}async function hs(){await xs.demoBioActivityCliffs()}async function ds(){await xs.demoBioAtomicLevel()}async function ms(e){await xs.sdfToJsonLib(e)}async function ps(e,t){return await xs.seq2atomic(e,t)}async function gs(e,t){return await xs.seqIdentity(e,t)}async function fs(e,t,n){await xs.detectMacromoleculeProbe(e,t,n)}async function ys(){return await xs.getSeqHelper()}async function bs(e,t,n){return await xs.getMolFromHelm(e,t,n)}!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(Io||(Io={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.monomerInfoPanel=async function(e){return await o.functions.call("Bio:MonomerInfoPanel",{monomerSv:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.applyNumberingScheme=async function(){return await o.functions.call("Bio:ApplyNumberingScheme",{})},e.scanLiabilities=async function(){return await o.functions.call("Bio:ScanLiabilities",{})},e.manageAnnotations=async function(){return await o.functions.call("Bio:ManageAnnotations",{})},e.sequenceColumnInput=async function(e,t){return await o.functions.call("Bio:SequenceColumnInput",{name:e,options:t})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.seqActivityCliffsInitFunction=async function(e){return await o.functions.call("Bio:SeqActivityCliffsInitFunction",{sp:e})},e.seqActivityCliffsTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SeqActivityCliffsTransform",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,options:a,isDemo:l,axesNames:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.sequenceSpaceTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTransform",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,options:s,clusterEmbeddings:a,embedColsNames:l,clusterColName:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.pepseaMsa=async function(e,t,n,i){return await o.functions.call("Bio:PepseaMsa",{sequenceCol:e,method:t,gapOpen:n,gapExtend:i})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesView",{path:e})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.monomerCollectionsApp=async function(){return await o.functions.call("Bio:MonomerCollectionsApp",{})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(Lo||(Lo={}));var vs=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},ws=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Cs=function(e,t){return function(n,i){t(n,i,e)}};const As=new Si;let Ss=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class xs{static async getMonomerLibHelper(){return await bn.getInstance()}static async initBio(){null==Ss&&(Ss=async function(){const e="Bio: _package.initBio()";As.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,_e.j)(),i=await As.getProperties(),r=new Ai(i);As.properties=r;const a=await bn.getInstance(),l=await(0,Le.u)();l.explicit&&(l.explicit=[],await(0,Le.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();As.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new so(a,n);As.completeInit(m,u,h,n),s.ObjectHandler.register(new zn),As.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[Eo]||(t.temp[Eo]=[]);let i=t.temp[Eo];i.forEach(e=>e.unsubscribe()),t.temp[Eo]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[xo];i.temp[xo]=!0;let l=null;try{l=As.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>$e.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],v=l.splitter(b),w=v?v.length:30,C=e.getTag(ue.gp.annotations)?24:0,A={WITH_TITLE:58,WITH_WEBLOGO:107+C,WITH_BOTH:156+C};let S;S=e.length>1e5||w<50?A.WITH_TITLE+C:e.length>5e4?A.WITH_WEBLOGO:A.WITH_BOTH;let x=null,E=null;const M=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{Co.clearAllCaches(),x&&(x.resetViewportTracking(),x.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(M);const T=o=>{const c=[],h=new wo(e,"Annotations");h.hasRegions()&&c.push({id:"annotations",track:h,priority:0});const g=new Ao(l,w,45,"WebLogo");x=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:1});const f=new So(l,w,45,"default","Conservation");E=f,c.push({id:"conservation",track:f,priority:2});const y=new bo({canvas:t.overlay,headerHeight:S,totalPositions:w+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<A.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);y.setupTooltipHandling(),c.sort((e,t)=>e.priority-t.priority),c.forEach(({id:e,track:t})=>{y.addTrack(e,t)}),y.setSelectionData(n,e,l),w>50&&!a&&(t.props.colHeaderHeight=S,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>y.detach()});const b=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==b?.dart)return;const i=t.bounds;if(!i)return;y.headerHeight=i.height;const o=p();y.positionWidth=o+8;const r=d();y.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();T(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Ss}static sequenceTooltip(e){const t=new Ti(e,As.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Tn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await Tn(l);c.forEach((e,t)=>{e.lib=l[t].lib});const{cappedMap:u,uncappedMap:h}=await async function(e,t,n){const i={};for(const t of e){if(!t.smiles)continue;const e={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source??""};i[t.smiles]||(i[t.smiles]=[]),i[t.smiles].push(e)}const o=e.map((e,n)=>({symbol:e.symbol,smiles:Bn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:t[n]?.lib?.source??""})).filter(e=>!!e.smiles&&!e.smiles.includes("[*:")),r=s.Column.fromList(s.COLUMN_TYPE.STRING,"CappedSmiles",o.map(e=>e.smiles));r.semType=s.SEMTYPE.MOLECULE;const a=await n.apply({molecule:r,targetNotation:s.chem.Notation.Smiles});if(!a||a.length!==r.length)throw new Error("Error canonicalizing capped monomer SMILES");const l={},c=a.toList();for(let e=0;e<c.length;e++){const t=c[e];if(!t)continue;o[e].smiles=t;const n=o[e];l[t]||(l[t]=[]),l[t].push(n)}return{cappedMap:l,uncappedMap:i}}(c,l,a),d=await async function(e,t,n){const i=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return kn([],t?void 0:e,t?e:void 0)}catch(t){return e}}),o=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesCorrected",i);o.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([o]);const r=await n.apply({molecule:o,targetNotation:s.chem.Notation.Smiles});if(!r||r.length!==o.length)throw new Error("Error canonicalizing molecules");return r.toList()}(e,t,a),m=new Array(d.length).fill(null).map(()=>[]),p=[];for(let e=0;e<d.length;e++){const t=d[e];if(!t)continue;const n=An(t,u,h);n.length>0?m[e]=n:p.push(e)}if(p.length>0)try{const{fpMap:e}=await async function(e){const t=Object.keys(e);if(0===t.length)return{fpMap:{},cappedSmilesList:[]};const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",t);n.semType=s.SEMTYPE.MOLECULE;const i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r={};for(let n=0;n<i.length;n++){const o=i.get(n);if(!o)continue;const s=o.toBinaryString(),a=e[t[n]]??[];r[s]||(r[s]=[]),r[s].push(...a)}return{fpMap:r,cappedSmilesList:t}}(u),t=await async function(e,t,n){const i=new Map;if(0===e.length||0===Object.keys(n).length)return i;const r=e.map(e=>t[e]??""),a=r.map(e=>{if(!e)return"";const t=Bn(e,Cn);return t!==e?o.chem.convert(t,s.chem.Notation.Unknown,s.chem.Notation.Smiles):e}),l=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMols",r);l.semType=s.SEMTYPE.MOLECULE;const c=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMolsCapped",a);c.semType=s.SEMTYPE.MOLECULE;const[u,h]=await Promise.all([o.functions.call("Chem:getMorganFingerprints",{molColumn:l}),o.functions.call("Chem:getMorganFingerprints",{molColumn:c})]);for(let t=0;t<e.length;t++){const o=e[t],r=u.get(t);if(r){const e=n[r.toBinaryString()];if(e&&e.length>0){i.set(o,e);continue}}const s=h.get(t);if(s){const e=n[s.toBinaryString()];e&&e.length>0&&i.set(o,e)}}return i}(p,d,e);for(const[e,n]of t)m[e]=n}catch(e){console.warn("Fingerprint fallback matching failed, continuing with SMILES matches only:",e)}const g=e.clone(),f=g.columns.addNewString(g.columns.getUnusedName("Matched monomer symbol")),y=g.columns.addNewString(g.columns.getUnusedName("Matched monomer smiles"));y.semType=s.SEMTYPE.MOLECULE;const b=g.columns.addNewString(g.columns.getUnusedName("Matched monomer source")),v=g.columns.addNewInt(g.columns.getUnusedName("Match count")),w=g.columns.addNewString(g.columns.getUnusedName("Match method"));g.columns.setOrder([t,f.name,y.name,b.name,v.name,w.name]);for(let e=0;e<m.length;e++){const t=m[e];if(0===t.length)continue;const n=Sn(t),i=xn(n,r);f.set(e,n.map(e=>e.symbol).join(" | "),!1),y.set(e,n[0].original??n[0].smiles,!1),b.set(e,i,!1),v.set(e,n.length,!1);const o=p.includes(e)?"fingerprint":"exact";w.set(e,o,!1)}return g}(e,t.name,As.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return As.monomerLib}static getSeqHandler(e){return As.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:As.name,name:t});if(1!==n.length)throw new Error(`Package '${As.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new Pi(i,As.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Kn()(e).addClass("d4-link-action"),e.onclick=async()=>await ti(),new s.Widget(e)}()}static GetRegionEditor(e){try{new Pi(e,As.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),As.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new fi;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new P({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Ce({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new Ue}static fastaSequenceCellRenderer(){return new Ue}static separatorSequenceCellRenderer(){return new Ue}static bilnSequenceCellRenderer(){return new Ue}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[me.j.notationProvider]=new Mo(n,As.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let i=As.properties?As.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));i=isNaN(t)?i:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);i=isNaN(t)?i:t}const o=r.input.int("Max Monomer Length",{value:i,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{o.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let a=As.properties?As.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(a=e.temp[".mm.cellRenderer.fontSize"]);const l=r.input.int("Font Size",{value:a,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),c=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),u=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),d=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let m=null;e.meta.units!==ue.Hi.HELM&&(m=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[l,o,c,h,u,d];m&&p.push(m);const g=r.inputs(p),f=(0,xt.Ln)(e),y=r.divV([]);if(f.length>0){const t=e.getTag(ue.gp.numberingScheme),i=f.filter(e=>e.category===Et.eI.Structure),o=f.filter(e=>e.category===Et.eI.Liability);if(t&&y.append(r.divText(`Numbering: ${t}`,{style:{fontSize:"12px",marginBottom:"4px"}})),i.length>0){const e=i.map(e=>e.name).join(", ");y.append(r.divText(`Regions: ${e}`,{style:{fontSize:"12px",marginBottom:"4px"}}))}if(o.length>0){const e=o.reduce((e,t)=>{const n=t.description?.match(/\((\d+) hits\)/);return e+(n?parseInt(n[1]):0)},0);y.append(r.divText(`Liabilities: ${o.length} rules (${e} hits)`,{style:{fontSize:"12px",marginBottom:"4px"}}))}const s=r.button("Manage",()=>{n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}),a=r.button("Clear All",()=>{(0,xt.OW)(e.dataFrame,e),e.dataFrame.fireValuesChanged()});y.append(r.divH([s,a],{style:{gap:"4px",marginTop:"4px"}}))}else{y.append(r.divText("No annotations",{style:{fontSize:"12px",color:"#888"}}));const e=r.button("Scan Liabilities",()=>{n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}),t=r.button("Apply Numbering",()=>{n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())});y.append(r.divH([e,t],{style:{gap:"4px",marginTop:"4px"}}))}const b=r.accordion();return b.addPane("Renderer Settings",()=>g),b.addPane("Annotations",()=>y),new s.Widget(b.root)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?Be.o.NUCLEOTIDE:Be.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===Be.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,Oe.MD)(n)}});const m=(0,xi.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,As.monomerLib,As.seqHelper)}static monomerInfoPanel(e){return function(e,t){const n=e.value;if(!n)return new s.Widget(r.divText("No monomer value."));const i=function(e){try{const t=e.cell?.column;if(t)return t.temp[pe.sc]??null}catch{}return null}(e),o=(i?i.canonicalize(n):n).split(pe.ot).map(e=>e.trim()).filter(e=>e.length>0).map(e=>({symbol:e,monomer:t.getMonomer(null,e)})).filter(e=>null!==e.monomer);if(0===o.length)return new s.Widget(r.divText(`Monomer '${n}' not found in the library.`));const a=r.accordion("Monomer");if(1===o.length){const e=o[0].monomer;a.addPane("Details",()=>Gn(e),!0),a.addPane("Molecule",()=>Vn(e),!0)}else for(const{symbol:e,monomer:t}of o)a.addPane(e,()=>r.divV([Gn(t),r.element("hr"),Vn(t)]),!0);return new s.Widget(a.root)}(e,As.monomerLib)}static macromoleculeDifferenceCellRenderer(){return new ze}static sequenceAlignment(e,t,n,i,o){const r=new ct(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new tt.oP}static vdRegionsViewer(){return new st}static getRegion(e,t,n,i){return Li(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=Li(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static applyNumberingScheme(){n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())}static scanLiabilities(){n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}static manageAnnotations(){n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}static sequenceColumnInput(e,t){return $o.create(e,t)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(Ne(e),!(0,hi.V)(t,"Activity Cliffs"))return;const p=c===l.c.UMAP?2e5:2e4,g=c===l.c.UMAP?5e3:2e3;if(e.rowCount>p)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${p}`);const f=Ee(e),y=async()=>{await s.Func.find({name:"seqActivityCliffsTransform"})[0].prepare({table:e,molecules:t,activities:n,similarity:i,methodName:c,similarityMetric:u,options:JSON.stringify(d),isDemo:m,axesNames:f}).call(void 0,void 0,{processed:!1}),Ne(e);const r=o.shell.tv,a=`Molecules: ${t.name}, activities: ${n.name}, method: ${c}, ${d?`options: ${JSON.stringify(d)},`:""} similarity: ${u}, similarity cutoff: ${i}`;r.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:f[0],yColumnName:f[1],color:n.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:"Activity cliffs",initializationFunction:"seqActivityCliffsInitFunction",description:a,descriptionVisibilityMode:"Never"})},b=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");try{e.rowCount>g&&!d?.[a.vb]?await new Promise((e,t)=>{r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{y().then(()=>e()).catch(e=>t(e))}).onCancel(()=>{e()}).show()}):await y()}catch(e){const[t,n]=(0,ve.AP)(e);throw As.logger.error(t,void 0,n),e}finally{b.close()}}static async seqActivityCliffsInitFunction(e){const t=e.dataFrame.getTag("seqActivityCliffsParams");if(!t)return void o.shell.error("Sequence activity cliffs parameters not found in table tags");const n=JSON.parse(t),i=e.dataFrame.col(n.seqColName),r=e.dataFrame.col(n.activityColName),a=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],l=await a.apply({col:i,metric:n.similarityMetric}),c=[e.getOptions().look.xColumnName,e.getOptions().look.yColumnName],u={units:i.meta.units,aligned:i.getTag(ue.gp.aligned),separator:i.getTag(ue.gp.separator),alphabet:i.getTag(ue.gp.alphabet)};await le(e,e.dataFrame,i,l,r,c,n.similarity,n.similarityMetric,n.options??{},s.SEMTYPE.MACROMOLECULE,u,dt,mt,yt,void 0,n.isDemo)}static async seqActivityCliffsTransform(e,t,i,o,r,a,l,c,u){await e.meta.detectSemanticTypes();const h=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];u||(u=Ee(e)),await async function(e,t,i,o,r,s,a,l){const c=l.inputs,u=await l.apply({[c[0].name]:t,[c[1].name]:r,...a.preprocessingFuncArgs??{}});let h=[];if(s===_){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([u.entries],o,[1],"MANHATTAN",[r],[u.options??{}],a?.maxIterations??5,a.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),h=[t.embedX,t.embedY]}else h=await U([u.entries],s,[r],[1],"MANHATTAN",{...a,distanceFnArgs:[u.options??{}]});if(h.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<h.length;++t)e.columns.addNewFloat(i[t]).init(e=>h[t][e])}(e,t,u,o,a,r,JSON.parse(l??"{}"),h);const d={seqColName:t.name,activityColName:i.name,similarityMetric:a,similarity:o,options:l??{},isDemo:c};e.setTag("seqActivityCliffsParams",JSON.stringify(d))}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ut(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ht.BQ)(e,As.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=D.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,a,l,c,u){if(Ne(e),!(0,hi.V)(t,"Sequence Space"))return;const h=e.columns.getUnusedName("Cluster (DBSCAN)"),d=Ee(e);let m;if(await s.Func.find({name:"sequenceSpaceTransform"})[0].prepare({table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:!1,options:JSON.stringify(l),clusterEmbeddings:c,embedColsNames:d,clusterColName:h}).call(void 0,void 0,{processed:!1}),r){Ne(e),m=o.shell.tv.scatterPlot({x:d[0],y:d[1],title:"Sequence space"});const r=`Molecules column: ${t.name}, method: ${n}, ${l?`options: ${JSON.stringify(l)},`:""} similarity: ${i}`;m.setOptions({description:r,descriptionVisibilityMode:"Never"}),c&&(m.props.colorColumnName=h)}return m}static async sequenceSpaceTransform(e,t,n,i,r,l,c,u,h){await e.meta.detectSemanticTypes();const d=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],m=JSON.parse(l??"{}"),p=o.shell.tv?.dataFrame==e?o.shell.tv:void 0;return await Te(e,[t],n,[i],[1],[d],"MANHATTAN",r,c??!1,{...m,preprocessingFuncArgs:[m.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:m?.[a.vb],tableView:p,embedColsNames:u,clusterColName:h})}static async moleculesToHelmTopMenu(e,t){const n=As.monomerLib,i=JSON.stringify(n.toJSON());await Io.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=ue.Hi.HELM,o.semType=s.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await xs.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ss;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??As.monomerLib,r=As.seqHelper,s=As.rdKitModule;await(0,Ri.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await ao(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){As.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await ao(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await ao(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=Hi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,mi.D)({},As.seqHelper).catch(e=>{const[t,n]=(0,ve.AP)(e);if(e instanceof di.Ap)return o.shell.warning(e.element),void As.logger.warning(t);o.shell.error(t),As.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,mi.D)({col:e,clustersCol:t,...n},As.seqHelper)}static async pepseaMsa(e,t="mafft --auto",n=1.53,i=0){return(0,pi.Gf)(e,t,n,i)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(As.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,hi.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>As.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Pe.me)()[0];(0,St.C)(e,As.seqHelper)}static convertColumnAction(e){(0,St.C)(e,As.seqHelper)}static monomerCellRenderer(){return new wi}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await s.delay(10),!(0,hi.V)(t,"Sequence space"))return e;const n=ge(t,As.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ve.uF.MONOMER,e.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ve.uF.MONOMER,o.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return As.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new Ct(As.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new At(As.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Pe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ht.a7(t,As.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=As.seqHelper;return $i(e,t,n,fe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=As.seqHelper;return $i(e,t,n,fe.SIMILARITY,i)}static async manageMonomerLibraries(){ti()}static async manageLibrariesView(){await ni()}static async manageMonomersView(){const e=await Ln.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(e){const t=await ni(!1);return t.parentCall=o.functions.getCurrentCall(),t}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await bn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await Ln.getInstance();(await e.getViewRoot(t,!0)).parentCall=o.functions.getCurrentCall(),e.resetCurrentRowFollowing()})})}static async monomerCollectionsApp(){return await async function(e=!0){if(e){const e=Array.from(o.shell.views).find(e=>e.name===Po.VIEW_NAME);if(e)return o.shell.v=e,e}const t=new Po,n=await t.init();return e&&o.shell.addView(n),n}(!1)}static saveAsFasta(){(0,qn.TE)()}static bioSubstructureFilter(){return new jn._i(As.seqHelper,As.logger)}static bioSubstructureFilterTest(){return new jn._i(As.seqHelper,As.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"webLogoLargeApp"),n=await As.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"webLogoAggApp"),n=await As.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Ni(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await As.files.readCsv("samples/HELM_empty_vals.csv"),n=new Ni(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,Ie.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(As.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(As.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,i){const r=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(r,t=>{const n=e.column,r=e.rowIndex,s=i.getSeqHandler(n),a=t===ue.Hi.SEPARATOR?As.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")});const s=e.column,a=(0,xt.Ln)(s);if(a.length>0&&new Ii.$(s).hasAnnotations()){const e=a.filter(e=>e.category===Et.eI.Structure);if(e.length>0){const r=t.group("Annotations");for(const t of e)t.start&&t.end&&r.item(`Extract ${t.name} as Column`,()=>{n.e(288).then(n.bind(n,9288)).then(e=>{try{e.extractAnnotatedRegion(s.dataFrame,s,t.name,i)}catch(e){o.shell.error(`Failed to extract region: ${e.message??e}`)}})});a.filter(e=>e.category===Et.eI.Liability).length>0&&r.item("Filter: Rows with Liability Hits",()=>{n.e(288).then(n.bind(n,9288)).then(e=>{e.filterByLiabilityHits(s.dataFrame,s)})})}}}(e,t,As.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await As.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Pe.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await As.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await xs.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Kn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),As.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await As.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await xs.toAtomicLevel(e,n,!0,!1),(0,Pe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Pe.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?xs.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await $i(i,n,t,fe.IDENTITY,As.seqHelper)).get(0)}catch(e){const[t,n]=(0,ve.AP)(e);throw As.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await s.delay(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await xs.initBio(),As.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=As.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,As.rdKitModule,i);return r.semType=s.SEMTYPE.MOLECULE,r}(0,t,n,As.monomerLib)}}vs([o.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getMonomerLibHelper",null),vs([o.decorators.init({tags:["init"]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"initBio",null),vs([o.decorators.func({meta:{role:"tooltip"},tags:["tooltip"]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"sequenceTooltip",null),vs([o.decorators.func({}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"standardiseMonomerLibrary",null),vs([o.decorators.func({"top-menu":"Bio | Manage | Match with Monomer Library...",description:"Matches molecules in a column with monomers from the selected library(s)"}),Cs(1,o.decorators.param({type:"column",options:{semType:"Molecule"}})),Cs(2,o.decorators.param({type:"string",options:{choices:["PEPTIDE","RNA","CHEM"],initialValue:"PEPTIDE",caption:"Polymer Type"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"matchWithMonomerLibrary",null),vs([o.decorators.func({outputs:[{type:"object",name:"monomerLib"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Object)],xs,"getBioLib",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Object)],xs,"getSeqHandler",null),vs([o.decorators.panel({name:"Bioinformatics | Get Region",description:"Creates a new column with sequences of the region between start and end",tags:["panel"]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"getRegionPanel",null),vs([o.decorators.panel({name:"Bioinformatics | Manage Monomer Libraries",meta:{"exclude-actions-panel":"true"},tags:["exclude-actions-panel"]}),Cs(0,o.decorators.param({name:"seqColumn",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Promise)],xs,"libraryPanel",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"GetRegionEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SplitToMonomersEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SequenceSpaceEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SeqActivityCliffsEditor",null),vs([o.decorators.func({name:"customSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=custom",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",s.GridCellRenderer)],xs,"customSequenceCellRenderer",null),vs([o.decorators.func({name:"fastaSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=fasta",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"fastaSequenceCellRenderer",null),vs([o.decorators.func({name:"separatorSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=separator",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"separatorSequenceCellRenderer",null),vs([o.decorators.func({name:"bilnSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=biln",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"bilnSequenceCellRenderer",null),vs([o.decorators.func({name:"refineNotationProviderForBiln",outputs:[{type:"bool",name:"result"}],tags:["notationRefiner"],meta:{role:"notationRefiner"}}),Cs(0,o.decorators.param({type:"column"})),Cs(1,o.decorators.param({type:"object"})),Cs(2,o.decorators.param({type:"string",options:{nullable:!0,optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,Object,Object]),ws("design:returntype",Boolean)],xs,"refineNotationProviderForBiln",null),vs([o.decorators.panel({name:"Bioinformatics | Sequence Renderer",tags:["panel"]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"macroMolColumnPropertyPanel",null),vs([o.decorators.panel({name:"Composition analysis",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",s.Widget)],xs,"compositionAnalysisWidget",null),vs([o.decorators.panel({name:"Monomer",tags:["bio","panel"],meta:{domain:"bio"}}),Cs(0,o.decorators.param({options:{semType:"Monomer"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",s.Widget)],xs,"monomerInfoPanel",null),vs([o.decorators.func({name:"MacromoleculeDifferenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"MacromoleculeDifference",columnTags:"quality=MacromoleculeDifference",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",ze)],xs,"macromoleculeDifferenceCellRenderer",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({options:{choices:["Local alignment","Global alignment"]}})),Cs(1,o.decorators.param({options:{choices:["AUTO","NUCLEOTIDES","BLOSUM45","BLOSUM50","BLOSUM62","BLOSUM80","BLOSUM90","PAM30","PAM70","PAM250","SCHNEIDER","TRANS"]}})),ws("design:type",Function),ws("design:paramtypes",[String,String,Number,String,String]),ws("design:returntype",void 0)],xs,"sequenceAlignment",null),vs([o.decorators.panel({name:"WebLogo",description:"WebLogo",tags:["viewer","panel"],meta:{icon:"files/icons/weblogo-viewer.svg",role:"viewer"},outputs:[{type:"viewer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"webLogoViewer",null),vs([o.decorators.panel({name:"VdRegions",description:"V-Domain regions viewer",tags:["viewer"],meta:{icon:"files/icons/vdregions-viewer.svg",role:"viewer"},outputs:[{type:"viewer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"vdRegionsViewer",null),vs([o.decorators.func({name:"getRegion",description:"Gets a new column with sequences of the region between start and end"}),Cs(0,o.decorators.param({type:"column"})),Cs(1,o.decorators.param({type:"string",options:{optional:!0}})),Cs(2,o.decorators.param({type:"string",options:{optional:!0}})),Cs(3,o.decorators.param({type:"string",options:{optional:!0,description:"Name of the column to be created"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,Object,Object,Object]),ws("design:returntype",s.Column)],xs,"getRegion",null),vs([o.decorators.func({name:"Get Region Top Menu",description:"Get sequences for a region specified from a Macromolecule","top-menu":"Bio | Calculate | Extract Region...",editor:"Bio:GetRegionEditor"}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequence column"}})),Cs(2,o.decorators.param({type:"string",options:{optional:!0,description:"Region start position name"}})),Cs(3,o.decorators.param({type:"string",options:{optional:!0,description:"Region end position name"}})),Cs(4,o.decorators.param({type:"string",options:{optional:!0,description:"Region column name"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Object,Object,Object]),ws("design:returntype",Promise)],xs,"getRegionTopMenu",null),vs([o.decorators.func({name:"Apply Numbering Scheme",description:"Assigns antibody numbering (IMGT/Kabat/Chothia/AHo) using AntPack","top-menu":"Bio | Annotate | Apply Numbering Scheme..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"applyNumberingScheme",null),vs([o.decorators.func({name:"Scan Liabilities",description:"Scans macromolecule sequences for deamidation, oxidation, and other liabilities","top-menu":"Bio | Annotate | Scan Liabilities..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"scanLiabilities",null),vs([o.decorators.func({name:"Manage Annotations",description:"View and manage sequence annotations on macromolecule columns","top-menu":"Bio | Annotate | Manage Annotations..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"manageAnnotations",null),vs([o.decorators.func({name:"Sequence Column Input",description:"Creates a new input for sequence columns with ability to extract a region"}),ws("design:type",Function),ws("design:paramtypes",[String,Object]),ws("design:returntype",Object)],xs,"sequenceColumnInput",null),vs([o.decorators.func({name:"Sequence Activity Cliffs",description:"Detects pairs of molecules with similar structure and significant difference in any given property","top-menu":"Bio | Analyze | Activity Cliffs...",editor:"Bio:SeqActivityCliffsEditor",outputs:[]}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({type:"string",options:{semType:"Macromolecule",description:"Input data table"}})),Cs(3,o.decorators.param({options:{initialValue:"80",description:"Similarity cutoff"}})),Cs(4,o.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Cs(5,o.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Cs(6,o.decorators.param({type:"func"})),Cs(7,o.decorators.param({type:"object",options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,s.Column,Number,String,String,s.Func,Object,Boolean]),ws("design:returntype",Promise)],xs,"activityCliffs",null),vs([o.decorators.func({name:"seqActivityCliffsInitFunction"}),Cs(0,o.decorators.param({type:"viewer"})),ws("design:type",Function),ws("design:paramtypes",[s.ScatterPlotViewer]),ws("design:returntype",Promise)],xs,"seqActivityCliffsInitFunction",null),vs([o.decorators.func({meta:{role:"transform"}}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"column",options:{type:"numerical"}})),Cs(3,o.decorators.param({options:{description:"Similarity cutoff",initialValue:"80"}})),Cs(4,o.decorators.param({type:"string"})),Cs(5,o.decorators.param({type:"string"})),Cs(6,o.decorators.param({options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,s.Column,Number,String,String,String,Boolean,Array]),ws("design:returntype",Promise)],xs,"seqActivityCliffsTransform",null),vs([o.decorators.func({name:"Encode Sequences",tags:["dim-red-preprocessing-function"],meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedDistanceFunctions:"Hamming,Levenshtein,Monomer chemical distance,Needlemann-Wunsch",role:"dim-red-preprocessing-function"},outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string"})),Cs(2,o.decorators.param({options:{initialValue:"1",caption:"Gap open penalty",optional:!0}})),Cs(3,o.decorators.param({options:{initialValue:"0.6",caption:"Gap extension penalty",optional:!0}})),Cs(4,o.decorators.param({options:{caption:"Fingerprint type",initialValue:"Morgan",choices:["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"],optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String,Number,Number,String]),ws("design:returntype",Promise)],xs,"macromoleculePreprocessingFunction",null),vs([o.decorators.func({name:"Helm Fingerprints",meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedUnits:"helm",supportedDistanceFunctions:"Tanimoto,Asymmetric,Cosine,Sokal"},outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string"})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String]),ws("design:returntype",Promise)],xs,"helmPreprocessingFunction",null),vs([o.decorators.func({name:"Sequence Space",description:"Creates 2D sequence space with projected sequences by pairwise distance","top-menu":"Bio | Analyze | Sequence Space...",editor:"Bio:SequenceSpaceEditor",outputs:[{type:"viewer",name:"result"}]}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Cs(3,o.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Cs(4,o.decorators.param({options:{initialValue:"true"}})),Cs(5,o.decorators.param({type:"func",options:{optional:!0}})),Cs(6,o.decorators.param({type:"object",options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0,initialValue:"true"}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String,String,Boolean,s.Func,Object,Boolean,Boolean]),ws("design:returntype",Promise)],xs,"sequenceSpaceTopMenu",null),vs([o.decorators.func({outputs:[{type:"viewer",name:"result"}],meta:{role:"transform"}}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"string"})),Cs(3,o.decorators.param({type:"string"})),Cs(4,o.decorators.param({options:{initialValue:"true"}})),Cs(5,o.decorators.param({options:{optional:!0}})),Cs(6,o.decorators.param({options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String,String,Boolean,String,Boolean,Array,String]),ws("design:returntype",Promise)],xs,"sequenceSpaceTransform",null),vs([o.decorators.func({name:"Molecules to HELM","top-menu":"Bio | Transform | Molecules to HELM...",description:"Converts Peptide molecules to HELM notation by matching with monomer library"}),Cs(0,o.decorators.param({name:"table",options:{description:"Input data table"}})),Cs(1,o.decorators.param({name:"molecules",options:{semType:"Molecule",description:"Molecule column"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column]),ws("design:returntype",Promise)],xs,"moleculesToHelmTopMenu",null),vs([o.decorators.func({name:"Molecule to HELM Single",description:"Converts a single molecule to HELM notation without requiring a table or column",outputs:[{name:"result",type:"string",options:{semType:"Macromolecule",units:"helm"}}]}),Cs(0,o.decorators.param({name:"molecule",options:{semType:"Molecule",description:"Input molecule"}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"moleculeToHelmSingle",null),vs([o.decorators.func({name:"To Atomic Level",description:"Converts sequences to molblocks","top-menu":"Bio | Transform | To Atomic Level..."}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",caption:"Sequence"}})),Cs(2,o.decorators.param({options:{initialValue:"true",caption:"Non-linear",description:"Slower mode for cycling/branching HELM structures"}})),Cs(3,o.decorators.param({options:{initialValue:"false",caption:"Highlight monomers",description:"Highlight monomers' substructures of the molecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Boolean,Boolean]),ws("design:returntype",Promise)],xs,"toAtomicLevel",null),vs([o.decorators.func({name:"To Atomic Level...",meta:{action:"to atomic level"}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Promise)],xs,"toAtomicLevelAction",null),vs([o.decorators.panel({name:"Molecular Structure",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({name:"sequence",type:"semantic_value",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",Promise)],xs,"toAtomicLevelPanel",null),vs([o.decorators.func({name:"To Atomic Level Single sequence",description:"Converts a single sequence to molblock",outputs:[{name:"molfile",type:"string",options:{semType:"Molecule"}}]}),Cs(0,o.decorators.param({name:"sequence",type:"string",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"toAtomicLevelSingleSeq",null),vs([o.decorators.panel({name:"Molecular 3D Structure",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({type:"semantic_value",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",Promise)],xs,"sequence3dStructureWidget",null),vs([o.decorators.panel({name:"MSA",description:"Performs multiple sequence alignment",tags:["bio","panel"],meta:{domain:"bio"},"top-menu":"Bio | Analyze | MSA..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"multipleSequenceAlignmentDialog",null),vs([o.decorators.func({name:"Multiple Sequence Alignment",description:"Multiple sequence alignment",meta:{domain:"bio"}}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"column"})),Cs(2,o.decorators.param({type:"object",options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[Object,Object,Object]),ws("design:returntype",Promise)],xs,"alignSequences",null),vs([o.decorators.func({name:"PepSeA",description:"Aligns non-canonical peptide sequences using PepSeA Docker container (MAFFT)",meta:{role:"sequenceMSA"},outputs:[{name:"result",type:"column"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string",options:{choices:["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],initialValue:"mafft --auto"}})),Cs(2,o.decorators.param({type:"double",options:{initialValue:"1.53"}})),Cs(3,o.decorators.param({type:"double",options:{initialValue:"0"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String,Number,Number]),ws("design:returntype",Promise)],xs,"pepseaMsa",null),vs([o.decorators.func({name:"Composition Analysis",description:"Visualizes sequence composition on a WebLogo plot","top-menu":"Bio | Analyze | Composition",meta:{icon:"files/icons/composition-analysis.svg"},outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"compositionAnalysis",null),vs([o.decorators.fileHandler({name:"importFasta",tags:["fileHandler"],description:"Opens FASTA file",ext:"fasta, fna, ffn, faa, frn, fa, fst"}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Array)],xs,"importFasta",null),vs([o.decorators.fileHandler({name:"importBam",tags:["fileHandler"],description:"Opens Bam file",ext:"bam, bai"}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Array)],xs,"importBam",null),vs([o.decorators.func({name:"convertDialog","top-menu":"Bio | Transform | Convert Sequence Notation..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"convertDialog",null),vs([o.decorators.func({name:"Convert Notation...",meta:{action:"Convert Notation..."}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",void 0)],xs,"convertColumnAction",null),vs([o.decorators.func({name:"monomerCellRenderer",tags:["cellRenderer"],meta:{cellType:"Monomer",columnTags:"quality=Monomer",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",wi)],xs,"monomerCellRenderer",null),vs([o.decorators.func({name:"testDetectMacromolecule"}),Cs(0,o.decorators.param({options:{choices:["Demo:Files/","System:AppData/"]}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"testDetectMacromolecule",null),vs([o.decorators.func({name:"Split to Monomers","top-menu":"Bio | Transform | Split to Monomers...",editor:"Bio:SplitToMonomersEditor"}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column]),ws("design:returntype",Promise)],xs,"splitToMonomersTopMenu",null),vs([o.decorators.func({name:"Bio: getHelmMonomers",outputs:[{name:"result",type:"object"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Array)],xs,"getHelmMonomers",null),vs([o.decorators.func({name:"Sequence Similarity Search",meta:{icon:"files/icons/sequence-similarity-viewer.svg",role:"viewer"},tags:["viewer"],outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ct)],xs,"similaritySearchViewer",null),vs([o.decorators.func({name:"similaritySearch",description:"Finds similar sequences","top-menu":"Bio | Search | Similarity Search",outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"similaritySearchTopMenu",null),vs([o.decorators.func({name:"Sequence Diversity Search",tags:["viewer"],meta:{icon:"files/icons/sequence-diversity-viewer.svg",role:"viewer"},outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",At)],xs,"diversitySearchViewer",null),vs([o.decorators.func({name:"diversitySearch",description:"Finds the most diverse sequences","top-menu":"Bio | Search | Diversity Search",outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"diversitySearchTopMenu",null),vs([o.decorators.editor({name:"SearchSubsequenceEditor",tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"searchSubsequenceEditor",null),vs([o.decorators.func({name:"Subsequence Search","top-menu":"Bio | Search | Subsequence Search ...",editor:"Bio:SearchSubsequenceEditor"}),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",void 0)],xs,"SubsequenceSearchTopMenu",null),vs([o.decorators.func({name:"Identity",description:"Adds a column with fraction of matching monomers","top-menu":"Bio | Calculate | Identity..."}),Cs(0,o.decorators.param({options:{description:"Table containing Macromolecule column"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Cs(2,o.decorators.param({options:{description:"Sequence,matching column format"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"sequenceIdentityScoring",null),vs([o.decorators.func({name:"Similarity",description:"Adds a column with similarity scores, calculated as sum of monomer fingerprint similarities","top-menu":"Bio | Calculate | Similarity..."}),Cs(0,o.decorators.param({options:{description:"Table containing Macromolecule column"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Cs(2,o.decorators.param({options:{description:"Sequence,matching column format"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"sequenceSimilarityScoring",null),vs([o.decorators.func({name:"Manage Monomer Libraries",description:"Manage HELM monomer libraries"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageMonomerLibraries",null),vs([o.decorators.func({name:"Manage Monomer Libraries View","top-menu":"Bio | Manage | Monomer Libraries"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageLibrariesView",null),vs([o.decorators.func({name:"manageMonomersView",description:"Edit and create monomers","top-menu":"Bio | Manage | Monomers"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageMonomersView",null),vs([o.decorators.app({tags:["app"],name:"Manage Monomer Libraries",browsePath:"Peptides",icon:"files/icons/monomers.png"}),Cs(0,o.decorators.param({options:{metaUrl:!0,optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"manageMonomerLibrariesView",null),vs([o.decorators.func({name:"Monomer Manager Tree Browser",meta:{role:"appTreeBrowser",app:"Manage Monomer Libraries"}}),ws("design:type",Function),ws("design:paramtypes",[s.TreeViewGroup]),ws("design:returntype",Promise)],xs,"manageMonomerLibrariesViewTreeBrowser",null),vs([o.decorators.app({tags:["app"],name:"Monomer Collections",browsePath:"Peptides",icon:"files/icons/monomers.png"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"monomerCollectionsApp",null),vs([o.decorators.fileExporter({description:"As FASTA..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"saveAsFasta",null),vs([o.decorators.func({name:"Bio Substructure Filter",description:"Substructure filter for macromolecules",tags:["filter"],meta:{semType:"Macromolecule",role:"filter"},outputs:[{type:"filter",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",jn._i)],xs,"bioSubstructureFilter",null),vs([o.decorators.func({name:"Bio Substructure Filter Test",description:"Substructure filter for Helm package tests",outputs:[{name:"result",type:"object"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",jn._i)],xs,"bioSubstructureFilterTest",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"webLogoLargeApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"webLogoAggApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getRegionApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getRegionHelmApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableSeparator",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableFasta",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableHelm",null),vs([o.decorators.func(),Cs(0,o.decorators.param({type:"object"})),Cs(1,o.decorators.param({type:"object"})),ws("design:type",Function),ws("design:paramtypes",[s.Cell,s.Menu]),ws("design:returntype",void 0)],xs,"addCopyMenu",null),vs([o.decorators.demo({description:"Sequence similarity tracking and evaluation dataset diversity",demoPath:"Bioinformatics | Similarity, Diversity",path:"/apps/Tutorials/Demo/Bioinformatics/Similarity,%20Diversity"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioSimilarityDiversity",null),vs([o.decorators.demo({description:"Exploring sequence space of Macromolecules, comparison with hierarchical clustering results",demoPath:"Bioinformatics | Sequence Space",path:"/apps/Tutorials/Demo/Bioinformatics/Sequence%20Space",meta:{isDemoDashboard:"true"}}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioSequenceSpace",null),vs([o.decorators.demo({description:"Activity Cliffs analysis on Macromolecules data",demoPath:"Bioinformatics | Activity Cliffs",path:"/apps/Tutorials/Demo/Bioinformatics/Activity%20Cliffs"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioActivityCliffs",null),vs([o.decorators.demo({description:"Atomic level structure of Macromolecules",demoPath:"Bioinformatics | Atomic Level",path:"/apps/Tutorials/Demo/Bioinformatics/Atomic%20Level"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioAtomicLevel",null),vs([o.decorators.func({name:"SDF to JSON Library"}),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame]),ws("design:returntype",Promise)],xs,"sdfToJsonLib",null),vs([o.decorators.func({friendlyName:"seq2atomic",description:"Converts a `Macromolecule` sequence to its atomic level `Molecule` representation",outputs:[{name:"molfile",type:"string",options:{semType:"Molecule"}}]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String,Boolean]),ws("design:returntype",Promise)],xs,"seq2atomic",null),vs([o.decorators.func({name:"seqIdentity",friendlyName:"seqIdentity",description:"Gets identity to a reference sequence"}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String,String]),ws("design:returntype",Promise)],xs,"seqIdentity",null),vs([o.decorators.func(),Cs(2,o.decorators.param({options:{initialValue:"100"}})),ws("design:type",Function),ws("design:paramtypes",[s.FileInfo,String,Number]),ws("design:returntype",Promise)],xs,"detectMacromoleculeProbe",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getSeqHelper",null),vs([o.decorators.func(),Cs(1,o.decorators.param({type:"column"})),Cs(2,o.decorators.param({options:{initialValue:"true"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Boolean]),ws("design:returntype",Promise)],xs,"getMolFromHelm",null);class Es{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}function Ms(){return As.logger.debug("Bio:test1() function"),{value:"value1"}}},4954(e,t,n){"use strict";n.d(t,{a7:()=>d,if:()=>p,BQ:()=>g,nI:()=>m});var i=n(4328),o=n(7389),r=n(6082),s=n(2003),a=n(439);async function l(e,t,n=!1,o){const s=t.getSeqHandler(e);let a;o??=new Map;const l=s.isHelm()?t.getSeqMonomers(e):Object.keys(s.stats.freq).filter(e=>""!==e);for(let e=0;e<l.length;e++)o.has(l[e])||o.set(l[e],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:e}),a=function(e,t,n=!1){const i=new Array(e.length);for(let o=0;o<e.length;o++){let r=0,s=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const c=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M V30 COUNTS ${c} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<c;e++){r=l.indexOf("\n",r)+1+31,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<u;e++){r=l.indexOf("\n",r)+1;const t=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(r+6,r+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",i[o]=a}return i}(a,o,n);else{a=new Array(e.length);for(let t=0;t<e.length;t++){const e=c(s.getSplitted(t),o,n);a[t]=e}}return r.Column.fromStrings("monomericMols",a)}function c(e,t,n=!1){let i="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";i+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,i+="M V30 BEGIN ATOM\n";for(let o=0;o<e.length;o++){const r=e.getCanonical(o);r!==a._S&&(i+=n?`M V30 ${o+1} R${t.get(r)} 0.000 0.000 0 0\n`:`M V30 ${o+1} At 0.000 0.000 0 0 MASS=${t.get(r)}\n`)}i+="M V30 END ATOM\n",i+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)i+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return i+="M V30 END BOND\n",i+="M V30 END CTAB\n",i+="M END",i}var u=n(4870);const h="substr_helm";class d{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,u.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then(()=>{setTimeout(()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))},100)})}updateInputs(){const e=this.units===s.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===s.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,u.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(s.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",()=>this.editHelmLinkAction(),void 0,{style:{position:"relative",left:"95px"}});const t=r.DataFrame.create(1);t.columns.addNewString(h).init(e=>""),t.col(h).semType=this.col.semType,t.col(h).meta.units=s.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(s.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK(async()=>{let e,n=this.units===s.Hi.HELM?t.get(h,0):this.substructureInput.value;this.units===s.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===s.Hi.HELM?await p(n,this.col,this.seqHelper):m(n,this.col),this.col.dataFrame.filter.and(e)}).show()}}function m(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,r=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(e,n):e,o=r.BitSet.create(t.length);for(let n=0;n<t.length;n++){const r=t.get(n);(r.match(i)||r===e)&&o.set(n,!0,!1)}return o}async function p(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await g(t,n,!0);const o=r.Column.string("helm",1).init(t=>e);o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=s.Hi.HELM;const a=await l(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:a.get(0),molBlockFailover:""})).get(0)}async function g(e,t,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await r.delay(10);const i=new Map,o=await l(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},3736(e,t,n){"use strict";n.d(t,{JG:()=>u,Ln:()=>r,Lz:()=>l,OW:()=>m,VT:()=>a,bq:()=>p,fh:()=>s,wi:()=>h,z5:()=>d});var i=n(2003),o=n(4517);function r(e){const t=e.getTag(i.gp.annotations);if(t)try{return JSON.parse(t)}catch{}const n=e.getTag(i.gp.regions);if(n)try{return JSON.parse(n).map((e,t)=>({id:`legacy-region-${t}`,name:e.name,description:e.description,start:e.start,end:e.end,visualType:o.ao.Region,category:o.eI.Structure,autoGenerated:!0}))}catch{}return[]}function s(e,t){e.setTag(i.gp.annotations,JSON.stringify(t));const n=t.filter(e=>e.category===o.eI.Structure);if(n.length>0){const t=n.filter(e=>null!=e.start&&null!=e.end).map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end}));e.setTag(i.gp.regions,JSON.stringify(t))}}function a(e){return`~${e}_annotations`}function l(e,t){const n=a(t.name);let o=e.columns.byName(n);return o||(o=e.columns.addNewString(n),t.setTag(i.gp.annotationColumnName,n)),o}const c=new WeakMap;function u(e,t){const n=c.get(e);if(n&&n.version===e.version&&void 0!==n.data[t])return n.data[t];const i=e.get(t);if(!i)return null;try{return JSON.parse(i)}catch{return null}}function h(e){const t=c.get(e);if(t&&t.version===e.version)return t.data;const n=new Array(e.length);for(let t=0;t<e.length;t++){const i=e.get(t);if(i)try{n[t]=JSON.parse(i)}catch{n[t]=null}else n[t]=null}return c.set(e,{version:e.version,data:n}),n}function d(e,t,n){e.set(t,n.length>0?JSON.stringify(n):"")}function m(e,t){t.setTag(i.gp.annotations,"");const n=a(t.name);e.columns.byName(n)&&e.columns.remove(n),t.setTag(i.gp.regions,"")}function p(e,t,n,i){let o=e;return n&&(o=o.filter(e=>null==e.endPositionIndex)),i&&(o=o.filter(e=>null!=e.endPositionIndex)),[...o,...t]}},966(e,t,n){"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(8012);function s(e,t,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,u]=a(e,t,l,n,o);return s&&!c&&i.shell.warning(u),c}function a(e,t,n,r=[],s=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(r.length>0&&!r.some(e=>o.toUpperCase()==e.toUpperCase()))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map(e=>`"${e}"`).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some(t=>e.toUpperCase()==t.toUpperCase())&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map(e=>`"${e}"`).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139(e,t,n){"use strict";var i,o,r,s,a;n.d(t,{J:()=>a,W_:()=>c,b9:()=>l,uF:()=>r}),function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(o||(o={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const l="3.3.1",c="sequenceMSA"},5433(e,t,n){"use strict";n.d(t,{C:()=>d});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(2738);let u=null,h=[];async function d(e,t){let n=e??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),d=s.notation;const m=o.divText("Current notation: "+d,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM,l.Hi.BILN],g=await c.$G.getProviderConstructors(),f=o.input.column("Column",{table:r.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),d=s.notation,d===l.Hi.HELM&&(v.value="/"),m.textContent="Current notation: "+d,b=p.filter(e=>e!==d),d===l.Hi.CUSTOM&&(b=[l.Hi.HELM]),d===l.Hi.HELM&&g.forEach(e=>{e.implementsFromHelm&&b.unshift(e.notationName)}),C=o.input.choice("Convert to",{value:b[0],items:b,onValueChanged:w}),w(),u?.clear(),void u?.add(o.div([m,f.root,C.root,v.root])))}),y=["-",".","/"];let b=p.filter(e=>e!==d);d===l.Hi.CUSTOM&&(b=[l.Hi.HELM]),d===l.Hi.HELM&&g.forEach(e=>{e.implementsFromHelm&&b.unshift(e.notationName)});const v=o.input.choice("Separator",{value:y[0],items:y}),w=()=>{C.value!==l.Hi.SEPARATOR?a()(v.root).hide():a()(v.root).show()};let C=o.input.choice("Convert to",{value:b[0],items:b,onValueChanged:w});w(),C.onChanged.subscribe(()=>{w()}),null==u&&(u=o.dialog("Convert Sequence Notation").add(o.div([m,f.root,C.root,v.root])).onOK(async()=>{const e=C.value,o=e===l.Hi.SEPARATOR?v.value:void 0;let s;!p.includes(e)&&g.find(t=>t.notationName===e)&&(s=g.find(t=>t.notationName===e)),await async function(e,t,n,o,s){if(s){const t=e.dataFrame.columns.getUnusedName(`${s.notationName}(${e.name})`),n=i.Column.string(t,e.length);return n.init(t=>{const n=e.get(t);try{return s.convertFromHelm(n,{})}catch(e){return console.error(`Error converting sequence at row ${t}: ${e instanceof Error?e.message:e}`),""}}),n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.CUSTOM,n.setTag("separator","-"),n.setTag("aligned","SEQ"),n.setTag("alphabet","UN"),n.setTag(".alphabetIsMultichar","true"),e.dataFrame.columns.add(n),await r.data.detectSemanticTypes(e.dataFrame),n}{const i=t.getSeqHandler(e).convert(n,o);e.dataFrame.columns.add(i);const s=await r.functions.call("Bio:detectMacromolecule",{col:i});return s&&(i.semType=s),await r.data.detectSemanticTypes(e.dataFrame),i}}(n,t,e,o,s)}).show({x:350,y:100}),h.push(u.onClose.subscribe(e=>{h.forEach(e=>{e.unsubscribe()}),h=[],u=null})))}},6956(e,t,n){"use strict";n.d(t,{m:()=>o,x:()=>i});const i="|",o="H"},2582(e,t,n){"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.x).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA|CHEM|BLOB)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA|CHEM|BLOB)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=e.indexOf("}$"),n=e.substring(0,t+1),i=e.indexOf("$",t+2),r=e.substring(t+2,i),a=n.split("}|");for(let e=0;e<a.length-1;e++)a[e]=a[e]+"}";this.simplePolymers=a.map(e=>new s(e)),this.connectionList=new o(r),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>t-e).find(t=>e>=t);if(null==n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},8604(e,t,n){"use strict";n.d(t,{G:()=>i});const i={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619(e,t,n){"use strict";n.d(t,{D:()=>T});var i=n(4328),o=n(6082),r=n(7389),s=n(2003),a=n(4025),l=n(608),c=n(966),u=n(4139),h=n(8012),d=n(5072),m=n.n(d),p=n(7825),g=n.n(p),f=n(7659),y=n.n(f),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=g(),E.insertStyleElement=C(),m()(x.A,E),x.A&&x.A.locals&&x.A.locals;class M{mode="kalign";currentFunc=null;currentFuncCall=null}async function T(e,t){return new Promise(async(n,d)=>{try{const m=e.col?.dataFrame??i.shell.t;if(!m)return void d(new l.Ap(r.divText("MSA requires a dataset with a macromolecule column.")));const p=e.col??m.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(!p)return void d(new l.Ap(r.divText("MSA requires a dataset with a macromolecule column.")));const g=new M;let f=p;const y=r.input.column("Sequence",{table:m,value:p,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return j.disabled=!0,await o.delay(0),void(y.value=f);f=e,j.disabled=!1,await B(e)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});y.setTooltip("Sequences column to use for alignment");const b=r.input.column("Clusters",{table:m,value:e.clustersCol});b.nullable=!0;const v=r.input.bool("Selected Rows Only",{value:!1}),w=r.input.float("Gap open",{value:e?.kalign?.gapOpen});w.setTooltip("Gap opening penalty at group-to-group alignment");const C=r.input.float("Gap extend",{value:e?.kalign?.gapExtend});C.setTooltip("Gap extension penalty to skip the alignment");const A=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});A.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const S=r.p(`Kalign version: ${u.b9}`,"kalign-version"),x=r.inputs([w,C,A]);x.hidden=!0;const E=r.button("Alignment parameters",()=>{x.hidden=!x.hidden,[w,C,A].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");E.classList.add("msa-params-button"),E.prepend(r.icons.settings(()=>null));const T=[x,E,S],L=o.Func.find({meta:{role:u.W_}});L.sort((e,t)=>{const n="true"===e.options.defaultAlignment?1:0;return("true"===t.options.defaultAlignment?1:0)-n});const _=r.input.choice("Engine",{value:L.length>0?L[0].friendlyName:"",items:L.map(e=>e.friendlyName)}),N=r.div("",{style:{fontSize:"12px",opacity:"0.7",marginBottom:"6px"}}),P=r.div(),R=r.button("Alignment parameters",()=>{P.hidden=!P.hidden},"Adjust engine-specific alignment parameters");R.classList.add("msa-params-button"),R.prepend(r.icons.settings(()=>null));const $=r.input.bool("Include HELM",{value:!0});$.setTooltip("Also add the aligned HELM column alongside the converted notation"),$.root.style.display="none";const O=[_.root,N,R,P,$.root];async function k(){P.innerHTML="",g.currentFuncCall=null;const e=_.value;if(g.currentFunc=L.find(t=>t.friendlyName===e)??null,N.textContent=g.currentFunc?.description??"",!g.currentFunc)return;g.currentFuncCall=g.currentFunc.prepare({});const t=await g.currentFuncCall.buildEditor(P);t.length>0&&"column"===t[0].inputType&&(t[0].root.style.display="none")}function H(e){g.mode=e;for(const t of T)t.style.display="kalign"===e?"":"none";for(const t of O)t.style.display="engine"===e?"":"none"}async function B(e){try{if(e.semType!==o.SEMTYPE.MACROMOLECULE)return;const n=(0,c.l)(e,e.name,t,[s.Hi.FASTA,s.Hi.SEPARATOR],[s.YI.DNA,s.YI.RNA,s.YI.PT])[0],r=(0,c.l)(e,e.name,t,[s.Hi.HELM],[])[0],l=(0,c.l)(e,e.name,t,[s.Hi.SEPARATOR,s.Hi.CUSTOM,s.Hi.BILN],[s.YI.UN])[0];if(n)H("kalign"),w.value=null,C.value=null,A.value=null;else if(r||l){if(0===L.length)return i.shell.warning("No MSA engines found for non-canonical sequences."),void H("kalign");H("engine"),await k();const t=e.temp?.[a.j.notationProvider],n=t?t.constructor:null,o=!0===n?.implementsFromHelm;$.root.style.display=o?"":"none"}else H("kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),h._package.logger.error(t)}}async function F(){const e=y.value;if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column must be of Macromolecule semantic type");return"kalign"===g.mode?D(e,m):G(e,m)}async function D(e,n){const i=n.columns.getUnusedName(`msa(${e.name})`),o=t.getSeqHandler(e),r=o.isFasta()?e:o.convert(s.Hi.FASTA);return(0,l.eE)(n,r,!1,i,b.value,w.value??void 0,C.value??void 0,A.value??void 0,v.value)}async function G(e,n){if(!g.currentFunc||!g.currentFuncCall)throw new Error("No MSA engine selected");const i=t.getSeqHandler(e);let r;r=i.isHelm()?e:(i.isSeparator()&&(i.alphabet,s.YI.UN),i.convert(s.Hi.HELM));const c=g.currentFunc,u=c.inputs[0].name,h={};for(let e=1;e<c.inputs.length;e++){const t=c.inputs[e].name;h[t]=g.currentFuncCall.inputs[t]}const d=await async function(e,t,n,i,r,a,c){const u=i.length;r??=o.Column.string("Clusters",u).init("0"),r.type!==o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING));const h=r.categories,d=r.getRawData(),m=new Array(h.length);if(a){const e=c.selection;if(0===e.trueCount)throw new Error("No selected rows in the table.");for(let t=-1;-1!==(t=e.findNext(t,!0));)(m[d[t]]??=[]).push(t)}else for(let e=0;e<u;e++)(m[d[e]]??=[]).push(e);(0,l.aZ)(m,h);const p=c.columns.getUnusedName(`msa(${i.name})`),g=new Array(u).fill("");let f=null;for(const r of m){if(!r||0===r.length)continue;const s=r.map(e=>i.get(e)),a=o.Column.fromStrings("seq",s);I(i,a),o.DataFrame.fromColumns([a]);const l=e.prepare({[t]:a,...n});await l.call();const c=l.getOutputParamValue();f=c;for(let e=0;e<r.length;e++)g[r[e]]=c.get(e)??""}const y=o.Column.fromStrings(p,g);if(f){y.meta.units=f.meta.units,y.semType=f.semType;for(const e of[s.gp.alphabet,s.gp.separator,s.gp.alphabetIsMultichar]){const t=f.getTag(e);t&&y.setTag(e,t)}}return y}(c,u,h,r,b.value,v.value,n),m=e.temp?.[a.j.notationProvider],p=m?m.constructor:null;if(p?.implementsFromHelm){const t=n.columns.getUnusedName(`msa(${e.name})`),i=o.Column.string(t,d.length);return i.init(e=>{const t=d.get(e);if(!t)return"";try{return p.convertFromHelm(t,{})}catch{return""}}),i.semType=o.SEMTYPE.MACROMOLECULE,i.meta.units=s.Hi.CUSTOM,i.setTag(s.gp.aligned,"SEQ.MSA"),i.setTag(s.gp.alphabet,s.YI.UN),$.value&&n.columns.add(d),i}return d}async function V(){if(!e.engine||"engine"!==g.mode)return;const t=L.find(t=>t.name===e.engine||t.friendlyName===e.engine);if(t&&(_.value=t.friendlyName,await k(),e.engineParams&&g.currentFuncCall))for(const[t,n]of Object.entries(e.engineParams))g.currentFuncCall.inputs[t]=n}_.onChanged.subscribe(()=>k());const q=r.dialog("MSA").add(y).add(b).add(_).add(N).add(R).add(P).add($).add(x).add(E).add(S).add(v).onOK(async()=>{const e=o.TaskBarProgressIndicator.create("Performing MSA...");try{const e=await F();m.columns.add(e),await i.data.detectSemanticTypes(m),e.meta.units!==s.Hi.HELM&&e.setTag(s.gp.aligned,"SEQ.MSA"),n(e)}catch(e){d(e)}finally{e.close()}}),j=q.getButton("OK");if(H("kalign"),y.fireChanged(),e.col){await B(e.col),await V();const U=o.TaskBarProgressIndicator.create("Performing MSA...");try{const W=await F();m.columns.add(W),await i.data.detectSemanticTypes(m),W.meta.units!==s.Hi.HELM&&W.setTag(s.gp.aligned,"SEQ.MSA"),n(W)}catch(z){d(z)}finally{U.close()}return}q.show()}catch(Y){d(Y)}})}function I(e,t){t.semType=e.semType,t.meta.units=e.meta.units;for(const n of[s.gp.alphabet,s.gp.separator,s.gp.alphabetIsMultichar]){const i=e.getTag(n);i&&t.setTag(n,i)}}},608(e,t,n){"use strict";n.d(t,{Ap:()=>H,aZ:()=>G,eE:()=>F});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),m=e=>"object"==typeof e&&null!==e||"function"==typeof e,p=new Map([["proxy",{canHandle:e=>m(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return g(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>m(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function g(e,t=self){t.addEventListener("message",function n(i){if(!i||!i.data)return;const{id:o,type:r,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const t=s.slice(0,-1).reduce((e,t)=>e[t],e),n=s.reduce((e,t)=>e[t],e);switch(r){case"GET":l=n;break;case"SET":t[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;g(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch(e=>({value:e,[d]:0})).then(e=>{const[i,s]=S(e);t.postMessage(Object.assign(Object.assign({},i),{id:o}),s),"RELEASE"===r&&(t.removeEventListener("message",n),f(t))})}),t.start&&t.start()}function f(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let i=!1;const o=new Proxy(n,{get(n,r){if(b(i),r===h)return()=>E(e,{type:"RELEASE",path:t.map(e=>e.toString())}).then(()=>{f(e),i=!0});if("then"===r){if(0===t.length)return{then:()=>o};const n=E(e,{type:"GET",path:t.map(e=>e.toString())}).then(x);return n.then.bind(n)}return v(e,[...t,r])},set(n,o,r){b(i);const[s,a]=S(r);return E(e,{type:"SET",path:[...t,o].map(e=>e.toString()),value:s},a).then(x)},apply(n,o,r){b(i);const s=t[t.length-1];if(s===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(e,t.slice(0,-1));const[a,l]=C(r);return E(e,{type:"APPLY",path:t.map(e=>e.toString()),argumentList:a},l).then(x)},construct(n,o){b(i);const[r,s]=C(o);return E(e,{type:"CONSTRUCT",path:t.map(e=>e.toString()),argumentList:r},s).then(x)}});return o}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map(e=>e[0]),w(t.map(e=>e[1]))]}const A=new WeakMap;function S(e){for(const[t,n]of p)if(n.canHandle(e)){const[i,o]=n.serialize(e);return[{type:"HANDLER",name:t,value:i},o]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return p.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise(i=>{const o=new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-");e.addEventListener("message",function t(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",t),i(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},t),n)})}const M="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",T=typeof window<"u"&&window.Blob&&new Blob([atob(M)],{type:"text/javascript;charset=utf-8"});function I(){const e=T&&(window.URL||window.webkitURL).createObjectURL(T);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+M)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const L={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class _{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},L,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new I;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map(([e,t])=>e)}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class R{constructor(e="categorial"){this.aa2num=P.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach(([e,t])=>this.num2aa[t]=e)}static _truncateSequence(e){let t=0,n=e.length;const i=["NH2","COOH"];if(e.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${i[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(i[1])){const t=i[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${i[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return R._dropDefises(R._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let i=0;i<t;++i){const t=e[i];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[i]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const i=e[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${e}'`),t+=this.num2aa[i]}return t}}var $=n(4139);const O="input.fa",k="result.fasta";class H extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function B(e){return e.reduce((e,t,n)=>e+`>sample${n+1}\n${t}\n`,"")}async function F(e,t,n=!1,i="",r=null,s,c,u,h){let d=t.toList();n&&(d=d.map(e=>R.clean(e).replace(/\-/g,"")));const m=t.length;r??=o.Column.string("Clusters",m).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const p=r.categories,g=r.getRawData(),f=new Array(p.length),y=new Array(p.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<m;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}G(y,p);const b=await new _(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),v=o.Column.string(i,m);for(let e=0;e<p.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=B(t);await b.fs.writeFile(O,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta -o ${k}${i}`);console.warn(o);const r=await b.cat(k);if(!r){const e=D(o,1);throw new Error(e)}const l=new a.m(r).sequencesArray,h=y[e];for(let e=0;e<l.length;++e)v.set(h[e],l[e])}const w=t.meta.units,C=t.getTag(l.gp.alphabet);return v.meta.units=w,v.setTag(l.gp.aligned,"SEQ.MSA"),v.setTag(l.gp.alphabet,C),v.semType=o.SEMTYPE.MACROMOLECULE,v}function D(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(e))&&(null==t||n.length<t);)n.push(o[1]);return n.join("\n")}function G(e,t){const n=e.map((e,t)=>[e,t]).filter(([e,t])=>1==e.length).map(([e,t])=>t);if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map(e=>{let o=t[e];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${e<n.length-1?", ":"."}`)}).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new H(e)}}},8152(e,t,n){"use strict";n.d(t,{Gf:()=>u});var i=n(4328),o=n(6082),r=n(2003),s=(n(608),n(4139)),a=n(8012);const l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"],c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}};async function u(e,t="mafft --auto",n=1.53,l=0){const u=await c.getDockerContainer(),d=e.length,m=[];for(let t=0;t<d;t++){const n=e.get(t);n&&m.push({ID:t.toString(),HELM:n})}const p=function(e,t){const n=new Array(t).fill(null);for(const t of e.Alignment)n[parseInt(t.ID)]=h(t);return n}(await async function(e,t,n,o,r,s){const l={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,l),d=window.performance.now();a._package.logger.debug(`Bio: requestAlignedObjects() ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok){if(m){const e=await h.json();if(e["pepsea-error"])throw new Error(`PepSeA error: ${e["pepsea-error"]}`);if(e["datagrok-error"])throw new Error(`Datagrok error: ${e["datagrok-error"]}`);throw new Error(h.statusText)}const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();return"pepsea-stderr"in p&&s?.warning(p["pepsea-stderr"]),p}(u.id,m,t,n,l),d);return function(e,t){const n=o.Column.fromStrings(e,t);return n.meta.units=r.Hi.SEPARATOR,n.setTag(r.gp.separator,s.J.SEPARATOR),n.setTag(r.gp.aligned,"SEQ.MSA"),n.setTag(r.gp.alphabet,r.YI.UN),n.setTag(r.gp.alphabetIsMultichar,"true"),n.semType=o.SEMTYPE.MACROMOLECULE,n}(e.dataFrame?.columns?.getUnusedName(`msa(${e.name})`)??`msa(${e.name})`,p)}function h(e){return Object.entries(e).filter(([e])=>!l.includes(e)).map(([,e])=>"-"!==e?e:"").join(s.J.SEPARATOR)}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(8012);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=u(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{n5:()=>C,oP:()=>L});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(8012);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,A=n(6307),S=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class x{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class E{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,S.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,A.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var T;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(T||(T={}));const I=new class{render=20};class L extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(T.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++L.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,I.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new E(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=T.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(T.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687(e,t,n){"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),v=n(8012);class w extends m.O{seqHelper;emptyProps=new m.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await o.delay(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await o.delay(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends m.O{emptyProps=new m.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new S(this.props.substructure,t,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use strict";const{normalizeIPv6:i,normalizeIPv4:o,removeDotSegments:r,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const o={};return i||(e=m(u(e,n),n),t=m(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(o.scheme=t.scheme,o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(t.path?("/"===t.path.charAt(0)?o.path=r(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?o.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:o.path=t.path:o.path="/"+t.path,o.path=r(o.path)),o.query=t.query):(o.path=e.path,void 0!==t.query?o.query=t.query:o.query=e.query),o.userinfo=e.userinfo,o.host=e.host,o.port=e.port),o.scheme=e.scheme),o.fragment=t.fragment,o}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=r(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const h=Array.from({length:127},(e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function m(e,t){const n=Object.assign({},t),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const e=o(r.host);if(!1===e.isIPV4){const t=i(e.host);r.host=t.host.toLowerCase(),a=t.isIPV6}else r.host=e.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&r.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(e){r.error=r.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),e&&e.parse&&e.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const p={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(m(e,t),t):"object"==typeof e&&(e=m(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(m(e,i),m(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(m(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(m(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:m};e.exports=p,e.exports.default=p,e.exports.fastUri=p},343(e){"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function r(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const o=`${n}:${t.nid||e.nid}`,r=l[o];e.path=void 0,r&&(e=r.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),o=`${n}:${t.nid||i}`,r=l[o];r&&(e=r.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914(e){"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834(e,t,n){"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(o)||[],[n]=t;return n?{host:l(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function s(e,t=!1){let n="",o=!0;for(const t of e){if(void 0===i[t])return;"0"!==t&&!0===o&&(o=!1),o||(n+=t)}return t&&0===n.length&&(n="0"),n}function a(e){if(c(e,":")<2)return{host:e,isIPV6:!1};const t=function(e){let t=0;const n={error:!1,address:"",zone:""},i=[],o=[];let r=!1,a=!1,l=!1;function c(){if(o.length){if(!1===r){const e=s(o);if(void 0===e)return n.error=!0,!1;i.push(e)}o.length=0}return!0}for(let s=0;s<e.length;s++){const u=e[s];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!c())break;r=!0}else o.push(u);else{if(!0===a&&(l=!0),!c())break;if(t++,i.push(":"),t>7){n.error=!0;break}s-1>=0&&":"===e[s-1]&&(a=!0)}}return o.length&&(r?n.zone=o.join(""):l?i.push(o.join("")):i.push(s(o))),n.address=i.join(""),n}(e);if(t.error)return{host:e,isIPV6:!1};{let e=t.address,n=t.address;return t.zone&&(e+="%"+t.zone,n+="%25"+t.zone),{host:e,escapedHost:n,isIPV6:!0}}}function l(e,t){let n="",i=!0;const o=e.length;for(let r=0;r<o;r++){const s=e[r];"0"===s&&i?(r+1<=o&&e[r+1]===t||r+1===o)&&(n+=s,i=!1):(i=s===t,n+=s)}return n}function c(e,t){let n=0;for(let i=0;i<e.length;i++)e[i]===t&&n++;return n}const u=/^\.\.?\//u,h=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,m=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e){const t=[];if(void 0!==e.userinfo&&(t.push(e.userinfo),t.push("@")),void 0!==e.host){let n=unescape(e.host);const i=r(n);if(i.isIPV4)n=i.host;else{const t=a(i.host);n=!0===t.isIPV6?`[${t.escapedHost}]`:e.host}t.push(n)}return"number"!=typeof e.port&&"string"!=typeof e.port||(t.push(":"),t.push(String(e.port))),t.length?t.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(u))e=e.replace(u,"");else if(e.match(h))e=e.replace(h,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(m);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837(e){"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079(e){"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},i={};function o(e){var t=i[e];if(void 0!==t)return t.exports;var r=i[e]={id:e,loaded:!1,exports:{}};return n[e].call(r.exports,r,r.exports,o),r.loaded=!0,r.exports}o.m=n,o.amdO={},o.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return o.d(t,{a:t}),t},o.d=(e,t)=>{for(var n in t)o.o(t,n)&&!o.o(e,n)&&Object.defineProperty(e,n,{enumerable:!0,get:t[n]})},o.f={},o.e=e=>Promise.all(Object.keys(o.f).reduce((t,n)=>(o.f[n](e,t),t),[])),o.u=e=>e+".js",o.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),o.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),o.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="bio:",o.l=(n,i,r,s)=>{if(e[n])e[n].push(i);else{var a,l;if(void 0!==r)for(var c=document.getElementsByTagName("script"),u=0;u<c.length;u++){var h=c[u];if(h.getAttribute("src")==n||h.getAttribute("data-webpack")==t+r){a=h;break}}a||(l=!0,(a=document.createElement("script")).charset="utf-8",o.nc&&a.setAttribute("nonce",o.nc),a.setAttribute("data-webpack",t+r),a.src=n),e[n]=[i];var d=(t,i)=>{a.onerror=a.onload=null,clearTimeout(m);var o=e[n];if(delete e[n],a.parentNode&&a.parentNode.removeChild(a),o&&o.forEach(e=>e(i)),t)return t(i)},m=setTimeout(d.bind(null,void 0,{type:"timeout",target:a}),12e4);a.onerror=d.bind(null,a.onerror),a.onload=d.bind(null,a.onload),l&&document.head.appendChild(a)}},o.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;o.g.importScripts&&(e=o.g.location+"");var t=o.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var n=t.getElementsByTagName("script");if(n.length)for(var i=n.length-1;i>-1&&(!e||!/^http(s?):/.test(e));)e=n[i--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/^blob:/,"").replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),o.p=e})(),(()=>{o.b="undefined"!=typeof document&&document.baseURI||self.location.href;var e={242:0,529:0};o.f.j=(t,n)=>{var i=o.o(e,t)?e[t]:void 0;if(0!==i)if(i)n.push(i[2]);else{var r=new Promise((n,o)=>i=e[t]=[n,o]);n.push(i[2]=r);var s=o.p+o.u(t),a=new Error;o.l(s,n=>{if(o.o(e,t)&&(0!==(i=e[t])&&(e[t]=void 0),i)){var r=n&&("load"===n.type?"missing":n.type),s=n&&n.target&&n.target.src;a.message="Loading chunk "+t+" failed.\n("+r+": "+s+")",a.name="ChunkLoadError",a.type=r,a.request=s,i[1](a)}},"chunk-"+t,t)}};var t=(t,n)=>{var i,r,[s,a,l]=n,c=0;if(s.some(t=>0!==e[t])){for(i in a)o.o(a,i)&&(o.m[i]=a[i]);l&&l(o)}for(t&&t(n);c<s.length;c++)r=s[c],o.o(e,r)&&e[r]&&e[r][0](),e[r]=0},n=self.webpackChunkbio=self.webpackChunkbio||[];n.forEach(t.bind(null,0)),n.push=t.bind(null,n.push.bind(n))})(),o.nc=void 0;var r=o(8012);bio=r})();
7
+ deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const i in e)"__proto__"!==i&&((Array.isArray(e[i])?t:n)[i]=e[i]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:o,it:s}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,r.propertyInData)(n,o,l,s.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(u,()=>{for(const t of c)(0,r.checkReportMissingProp)(e,t)}):(n.if(i._`${u} && (${(0,r.checkMissingProp)(e,c,a)})`),(0,r.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:i,keyword:s,it:a}=e,l=n.name("valid");for(const c in t)(0,o.alwaysValidSchema)(a,t[c])||(n.if((0,r.propertyInData)(n,i,c,a.opts.ownProperties),()=>{const t=e.subschema({keyword:s,schemaProp:c},l);e.mergeValidEvaluated(t,l)},()=>n.var(l,!0)),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=s},4845(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,i.validateSchemaDeps)(e)};t.default=o},1239(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>i.str`must match "${e.ifClause}" schema`,params:({params:e})=>i._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:r}=e;void 0===n.then&&void 0===n.else&&(0,o.checkStrictMode)(r,'"if" without "then" and "else" is ignored');const a=s(r,"then"),l=s(r,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,i.not)(u),h("else"));function h(n,o){return()=>{const r=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(r,c),o?t.assign(o,i._`${n}`):e.setParams({ifClause:n})}}e.pass(c,()=>e.error(!0))}};function s(e,t){const n=e.schema[t];return void 0!==n&&!(0,o.alwaysValidSchema)(e,n)}t.default=r},6378(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5457),o=n(5354),r=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),u=n(8660),h=n(117),d=n(5333),m=n(7923),p=n(6505),g=n(6163),f=n(5844),y=n(1239),b=n(4426);t.default=function(e=!1){const t=[m.default,p.default,g.default,f.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(o.default,s.default):t.push(i.default,r.default),t.push(a.default),t}},494(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const i=n(9029),o=n(4227),r=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,o.alwaysValidSchema)(n,t)||e.ok((0,r.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:r,parentSchema:s,data:a,keyword:l,it:c}=e;!function(e){const{opts:i,errSchemaPath:r}=c,s=n.length,a=s===e.minItems&&(s===e.maxItems||!1===e[t]);if(i.strictTuples&&!a){const e=`"${l}" is ${s}-tuple, but minItems or maxItems/${t} are not specified or different at path "${r}"`;(0,o.checkStrictMode)(c,e,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=o.mergeEvaluated.items(r,n.length,c.items));const u=r.name("valid"),h=r.const("len",i._`${a}.length`);n.forEach((t,n)=>{(0,o.alwaysValidSchema)(c,t)||(r.if(i._`${h} > ${n}`,()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u)),e.ok(u))})}t.validateTuple=a,t.default=s},3966(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:i}=e,{prefixItems:a}=n;i.items=!0,(0,o.alwaysValidSchema)(i,t)||(a?(0,s.validateAdditionalItems)(e,a):e.ok((0,r.validateArray)(e)))}};t.default=a},7923(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:o}=e;if((0,i.alwaysValidSchema)(o,n))return void e.fail();const r=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},r),e.failResult(r,()=>e.reset(),()=>e.error())},error:{message:"must NOT be valid"}};t.default=o},6163(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>i._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&r.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block(function(){a.forEach((n,r)=>{let a;(0,o.alwaysValidSchema)(s,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:r,compositeRule:!0},u),r>0&&t.if(i._`${u} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${r}]`).else(),t.if(u,()=>{t.assign(l,!0),t.assign(c,r),a&&e.mergeEvaluated(a,i.Name)})})}),e.result(l,()=>e.reset(),()=>e.error(!0))}};t.default=r},5333(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,i.allSchemaProperties)(n),d=h.filter(e=>(0,r.alwaysValidSchema)(c,n[e]));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const m=u.strictSchema&&!u.allowMatchingProperties&&l.properties,p=t.name("valid");!0===c.props||c.props instanceof o.Name||(c.props=(0,s.evaluatedPropsToName)(t,c.props));const{props:g}=c;function f(e){for(const t in m)new RegExp(e).test(t)&&(0,r.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,r=>{t.if(o._`${(0,i.usePattern)(e,n)}.test(${r})`,()=>{const i=d.includes(n);i||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:r,dataPropType:s.Type.Str},p),c.opts.unevaluated&&!0!==g?t.assign(o._`${g}[${r}]`,!0):i||c.allErrors||t.if((0,o.not)(p),()=>t.break())})})}!function(){for(const e of h)m&&f(e),c.allErrors?y(e):(t.var(p,!0),y(e),t.if(p))}()}};t.default=a},5354(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(494),o={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,i.validateTuple)(e,"items")};t.default=o},117(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),o=n(5765),r=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,o.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=r.mergeEvaluated.props(t,(0,r.toHash)(u),c.props));const h=u.filter(e=>!(0,r.alwaysValidSchema)(c,n[e]));if(0===h.length)return;const d=t.name("valid");for(const n of h)m(n)?p(n):(t.if((0,o.propertyInData)(t,l,n,c.opts.ownProperties)),p(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function m(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function p(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},2094(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>i._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e;if((0,o.alwaysValidSchema)(s,n))return;const a=t.name("valid");t.forIn("key",r,n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,i.not)(a),()=>{e.error(!0),s.allErrors||t.break()})}),e.ok(a)}};t.default=r},4426(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,i.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=o},5765(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const i=n(9029),o=n(4227),r=n(2023),s=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return i._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} === undefined`;return o?(0,i.or)(r,(0,i.not)(l(e,t,n))):r}function u(e){return e?Object.keys(e).filter(e=>"__proto__"!==e):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:o,it:r}=e;n.if(c(n,o,t,r.opts.ownProperties),()=>{e.setParams({missingProperty:i._`${t}`},!0),e.error()})},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},o,r){return(0,i.or)(...o.map(o=>(0,i.and)(c(e,t,o,n.ownProperties),i._`${r} = ${o}`)))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,o){const r=i._`${t}${(0,i.getProperty)(n)} !== undefined`;return o?i._`${r} && ${l(e,t,n)}`:r},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter(n=>!(0,o.alwaysValidSchema)(e,t[n]))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:o,schemaPath:s,errorPath:a},it:l},c,u,h){const d=h?i._`${e}, ${t}, ${o}${s}`:t,m=[[r.default.instancePath,(0,i.strConcat)(r.default.instancePath,a)],[r.default.parentData,l.parentData],[r.default.parentDataProperty,l.parentDataProperty],[r.default.rootData,r.default.rootData]];l.opts.dynamicRef&&m.push([r.default.dynamicAnchors,r.default.dynamicAnchors]);const p=i._`${d}, ${n.object(...m)}`;return u!==i.nil?i._`${c}.call(${u}, ${p})`:i._`${c}(${p})`};const h=i._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const o=t.unicodeRegExp?"u":"",{regExp:r}=t.code,a=r(n,o);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===r.code?h:(0,s.useFunc)(e,r)}(${n}, ${o})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:r,it:s}=e,a=t.name("valid");if(s.allErrors){const e=t.let("valid",!0);return l(()=>t.assign(e,!1)),e}return t.var(a,!0),l(()=>t.break()),a;function l(s){const l=t.const("len",i._`${n}.length`);t.forRange("i",0,l,n=>{e.subschema({keyword:r,dataProp:n,dataPropType:o.Type.Num},a),t.if((0,i.not)(a),s)})}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:r,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some(e=>(0,o.alwaysValidSchema)(s,e))&&!s.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block(()=>n.forEach((n,o)=>{const s=e.subschema({keyword:r,schemaProp:o,compositeRule:!0},l);t.assign(a,i._`${a} || ${l}`),e.mergeValidEvaluated(s,l)||t.if((0,i.not)(a))})),e.result(a,()=>e.reset(),()=>e.error(!0))}},3463(e,t){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3463),o=n(3693),r=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,o.default];t.default=r},3693(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const i=n(4551),o=n(5765),r=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:o}=e,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:m}=o,{root:p}=l;if(("#"===n||"#/"===n)&&s===p.baseId)return function(){if(l===p)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:p});return h(e,r._`${n}.validate`,p,p.$async)}();const g=a.resolveRef.call(m,p,s,n);if(void 0===g)throw new i.default(o.opts.uriResolver,s,n);return g instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(g):function(i){const o=t.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,r.stringify)(i)}:{ref:i}),s=t.name("valid"),a=e.subschema({schema:i,dataTypes:[],schemaPath:r.nil,topSchemaRef:o,errSchemaPath:n},s);e.mergeEvaluated(a),e.ok(s)}(g)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):r._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,i){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,m=d.passContext?s.default.this:r.nil;function p(e){const t=r._`${e}.errors`;a.assign(s.default.vErrors,r._`${s.default.vErrors} === null ? ${t} : ${s.default.vErrors}.concat(${t})`),a.assign(s.default.errors,r._`${s.default.vErrors}.length`)}function g(e){var t;if(!c.opts.unevaluated)return;const i=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const t=a.var("props",r._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,r.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const t=a.var("items",r._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,r.Name)}}i?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try(()=>{a.code(r._`await ${(0,o.callValidateCode)(e,t,m)}`),g(t),u||a.assign(n,!0)},e=>{a.if(r._`!(${e} instanceof ${c.ValidationError})`,()=>a.throw(e)),p(e),u||a.assign(n,!1)}),e.ok(n)}():e.result((0,o.callValidateCode)(e,t,m),()=>g(t),()=>p(t))}t.getValidate=u,t.callRef=h,t.default=c},6653(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(7652),r=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===o.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>i._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:l,parentSchema:c,it:u}=e,{oneOf:h}=c;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!h)throw new Error("discriminator: requires oneOf keyword");const m=t.let("valid",!1),p=t.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function g(n){const o=t.name("valid"),r=e.subschema({keyword:"oneOf",schemaProp:n},o);return e.mergeEvaluated(r,i.Name),o}t.if(i._`typeof ${p} == "string"`,()=>function(){const n=function(){var e;const t={},n=o(c);let i=!0;for(let t=0;t<h.length;t++){let c=h[t];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,u.self.RULES)){const e=c.$ref;if(c=r.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),c instanceof r.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(u.opts.uriResolver,u.baseId,e)}const m=null===(e=null==c?void 0:c.properties)||void 0===e?void 0:e[d];if("object"!=typeof m)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||o(c)),l(m,t)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return t;function o({required:e}){return Array.isArray(e)&&e.includes(d)}function l(e,t){if(e.const)m(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of e.enum)m(n,t)}}function m(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${d}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(i._`${p} === ${e}`),t.assign(m,g(n[e]));t.else(),e.error(!1,{discrError:o.DiscrError.Mapping,tag:p,tagName:d}),t.endIf()}(),()=>e.error(!1,{discrError:o.DiscrError.Tag,tag:p,tagName:d})),e.ok(m)}};t.default=l},7652(e,t){"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),u=n(9857),h=[s.default,i.default,o.default,(0,r.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},6144(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),o=n(7060),r=n(6378),s=n(7532),a=n(9857),l=[i.default,o.default,(0,r.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},2476(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const i=n(9029),o=n(2023),r=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=i._`${o.default.dynamicAnchors}${(0,i.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:i}=e.it,{root:o,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=i.opts,h=new r.SchemaEnv({schema:n,schemaId:u,root:o,baseId:a,localRefs:l,meta:c});return r.compileSchema.call(i,h),(0,s.getValidate)(e,h)}(e);n.if(i._`!${l}`,()=>n.assign(l,c))}t.dynamicAnchor=l,t.default=a},3252(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const i=n(9029),o=n(2023),r=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:s,it:a}=e;if("#"!==t[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",i._`${o.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,i){return i?()=>n.block(()=>{(0,r.callRef)(e,t),n.let(i,!0)}):()=>(0,r.callRef)(e,t)}}t.dynamicRef=a,t.default=s},5520(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(3252),r=n(2721),s=n(3799),a=[i.default,o.default,r.default,s.default];t.default=a},2721(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),o=n(4227),r={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,i.dynamicAnchor)(e,""):(0,o.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=r},3799(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3252),o={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,i.dynamicRef)(e,e.schema)};t.default=o},4737(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match format "${e}"`,params:({schemaCode:e})=>i._`{format: ${e}}`},code(e,t){const{gen:n,data:o,$data:r,schema:s,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(r?function(){const r=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${r}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,()=>n.assign(l,i._`${s}.type || "string"`).assign(u,i._`${s}.validate`),()=>n.assign(l,i._`"string"`).assign(u,s)),e.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${u}`,function(){const e=h.$async?i._`(${s}.async ? await ${u}(${o}) : ${u}(${o}))`:i._`${u}(${o})`,n=i._`(typeof ${u} == "function" ? ${e} : ${u}.test(${o}))`;return i._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const r=d.formats[s];if(!r)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${s}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===r)return;const[a,l,m]=function(e){const t=e instanceof RegExp?(0,i.regexpCode)(e):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,o=n.scopeValue("formats",{key:s,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,o]:[e.type||"string",e.validate,i._`${o}.validate`]}(r);a===t&&e.pass(function(){if("object"==typeof r&&!(r instanceof RegExp)&&r.async){if(!h.$async)throw new Error("async format in sync schema");return i._`await ${m}(${o})`}return"function"==typeof l?i._`${m}(${o})`:i._`${m}.test(${o})`}())}())}};t.default=o},7532(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=[n(4737).default];t.default=i},9857(e,t){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1846),o=n(4845),r=n(2626),s=[i.default,o.default,r.default];t.default=s},3265(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(392),o=n(3445),r=[i.default,o.default];t.default=r},3445(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:r,it:s}=e,a=s.items||0;if(!0===a)return;const l=t.const("len",i._`${r}.length`);if(!1===n)e.setParams({len:a}),e.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,o.alwaysValidSchema)(s,n)){const n=t.var("valid",i._`${l} <= ${a}`);t.if((0,i.not)(n),()=>function(n,r){t.forRange("i",r,l,r=>{e.subschema({keyword:"unevaluatedItems",dataProp:r,dataPropType:o.Type.Num},n),s.allErrors||t.if((0,i.not)(n),()=>t.break())})}(n,a)),e.ok(n)}s.items=!0}};t.default=r},392(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>i._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:s,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(r){if(!1===n)return e.setParams({unevaluatedProperty:r}),e.error(),void(c||t.break());if(!(0,o.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:r,dataPropType:o.Type.Str},n),c||t.if((0,i.not)(n),()=>t.break())}}u instanceof i.Name?t.if(i._`${u} !== true`,()=>t.forIn("key",s,e=>t.if(function(e,t){return i._`!${e} || !${e}[${t}]`}(u,e),()=>h(e)))):!0!==u&&t.forIn("key",s,e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const o in e)!0===e[o]&&n.push(i._`${t} !== ${o}`);return(0,i.and)(...n)}(u,e),()=>h(e))),l.props=!0,e.ok(i._`${a} === ${r.default.errors}`)}};t.default=s},7935(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>i._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:s,schemaCode:a,schema:l}=e;s||l&&"object"==typeof l?e.fail$data(i._`!${(0,o.useFunc)(t,r.default)}(${n}, ${a})`):e.fail(i._`${l} !== ${n}`)}};t.default=s},1846(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),o={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:e=>(0,i.validatePropertyDeps)(e)};t.default=o},8643(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>i._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:s,schema:a,schemaCode:l,it:c}=e;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,o.useFunc)(t,r.default);let m;if(u||s)m=t.let("valid"),e.block$data(m,function(){t.assign(m,!1),t.forOf("v",l,e=>t.if(i._`${d()}(${n}, ${e})`,()=>t.assign(m,!0).break()))});else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);m=(0,i.or)(...a.map((t,o)=>function(e,t){const o=a[t];return"object"==typeof o&&null!==o?i._`${d()}(${n}, ${e}[${t}])`:i._`${n} === ${o}`}(e,o)))}e.pass(m)}};t.default=s},7060(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5882),o=n(3439),r=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),u=n(617),h=n(7935),d=n(8643),m=[i.default,o.default,r.default,s.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=m},2626(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),o={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,i.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=o},1163(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxItems"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`${n}.length ${r} ${o}`)}};t.default=o},7307(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:s,it:a}=e,l="maxLength"===t?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,o.useFunc)(e.gen,r.default)}(${n})`;e.fail$data(i._`${c} ${l} ${s}`)}};t.default=s},5882(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=i.operators,r={maximum:{okStr:"<=",ok:o.LTE,fail:o.GT},minimum:{okStr:">=",ok:o.GTE,fail:o.LT},exclusiveMaximum:{okStr:"<",ok:o.LT,fail:o.GTE},exclusiveMinimum:{okStr:">",ok:o.GT,fail:o.LTE}},s={message:({keyword:e,schemaCode:t})=>i.str`must be ${r[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>i._`{comparison: ${r[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(r),type:"number",schemaType:"number",$data:!0,error:s,code(e){const{keyword:t,data:n,schemaCode:o}=e;e.fail$data(i._`${n} ${r[t].fail} ${o} || isNaN(${n})`)}};t.default=a},4486(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o}=e,r="maxProperties"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`Object.keys(${n}).length ${r} ${o}`)}};t.default=o},3439(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>i.str`must be multiple of ${e}`,params:({schemaCode:e})=>i._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:o,it:r}=e,s=r.opts.multipleOfPrecision,a=t.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;e.fail$data(i._`(${o} === 0 || (${a} = ${n}/${o}, ${l}))`)}};t.default=o},422(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>o.str`must match pattern "${e}"`,params:({schemaCode:e})=>o._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:r,schemaCode:s,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?o._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(e,r);e.fail$data(o._`!${c}.test(${t})`)}};t.default=r},4003(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),o=n(9029),r=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>o.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>o._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:s,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(o.nil,d);else for(const t of n)(0,i.checkReportMissingProp)(e,t)}():function(){const r=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,()=>function(n,r){e.setParams({missingProperty:n}),t.forOf(n,s,()=>{t.assign(r,(0,i.propertyInData)(t,a,n,u.ownProperties)),t.if((0,o.not)(r),()=>{e.error(),t.break()})},o.nil)}(r,n)),e.ok(n)}else t.if((0,i.checkMissingProp)(e,n,r)),(0,i.reportMissingProp)(e,r),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:i}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!i.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,r.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",s,n=>{e.setParams({missingProperty:n}),t.if((0,i.noPropertyInData)(t,a,n,u.ownProperties),()=>e.error())})}}};t.default=s},617(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(208),o=n(9029),r=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>o.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>o._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),m=c.items?(0,i.getSchemaTypes)(c.items):[];function p(r,s){const a=t.name("item"),l=(0,i.checkDataTypes)(m,a,h.opts.strictNumbers,i.DataType.Wrong),c=t.const("indices",o._`{}`);t.for(o._`;${r}--;`,()=>{t.let(a,o._`${n}[${r}]`),t.if(l,o._`continue`),m.length>1&&t.if(o._`typeof ${a} == "string"`,o._`${a} += "_"`),t.if(o._`typeof ${c}[${a}] == "number"`,()=>{t.assign(s,o._`${c}[${a}]`),e.error(),t.assign(d,!1).break()}).code(o._`${c}[${a}] = ${r}`)})}function g(i,a){const l=(0,r.useFunc)(t,s.default),c=t.name("outer");t.label(c).for(o._`;${i}--;`,()=>t.for(o._`${a} = ${i}; ${a}--;`,()=>t.if(o._`${l}(${n}[${i}], ${n}[${a}])`,()=>{e.error(),t.assign(d,!1).break(c)})))}e.block$data(d,function(){const i=t.let("i",o._`${n}.length`),r=t.let("j");e.setParams({i,j:r}),t.assign(d,!0),t.if(o._`${i} > 1`,()=>(m.length>0&&!m.some(e=>"object"===e||"array"===e)?p:g)(i,r))},o._`${u} === false`),e.ok(d)}};t.default=a},5488(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=s},6520(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-collections-view {\n padding: 16px;\n overflow-y: auto;\n height: 100%;\n}\n\n.monomer-collections-grid {\n display: flex;\n flex-wrap: wrap;\n gap: 16px;\n align-content: flex-start;\n}\n\n.monomer-collection-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 1px solid var(--grey-2);\n border-radius: 8px;\n background: var(--white);\n display: flex;\n flex-direction: column;\n overflow: hidden;\n transition: box-shadow 0.2s ease;\n}\n\n.monomer-collection-card:hover {\n box-shadow: 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-selected {\n border-color: #ff8c00;\n box-shadow: 0 0 0 1px #ff8c00;\n}\n\n.monomer-collection-card-selected:hover {\n box-shadow: 0 0 0 1px #ff8c00, 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-header {\n padding: 12px 14px 8px 14px;\n border-bottom: 1px solid var(--grey-2);\n flex-shrink: 0;\n}\n\n.monomer-collection-card-title {\n font-size: 14px;\n font-weight: 600;\n color: var(--grey-6);\n margin: 0;\n overflow: hidden;\n text-overflow: ellipsis;\n white-space: nowrap;\n}\n\n.monomer-collection-card-description {\n font-size: 11px;\n color: var(--grey-4);\n margin: 4px 0 0 0;\n overflow: hidden;\n text-overflow: ellipsis;\n display: -webkit-box;\n -webkit-line-clamp: 2;\n -webkit-box-orient: vertical;\n}\n\n.monomer-collection-card-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 3px;\n margin: 4px 0 0 0;\n}\n\n.monomer-collection-card-tag {\n display: inline-block;\n padding: 1px 6px;\n border-radius: 3px;\n background: #e8f0fe;\n border: 1px solid var(--blue-2, #aecbfa);\n font-size: 10px;\n color: var(--blue-3, #4285f4);\n}\n\n.monomer-collection-card-meta {\n font-size: 10px;\n color: var(--grey-3);\n margin: 4px 0 0 0;\n}\n\n.monomer-collections-search {\n margin-bottom: 12px;\n}\n\n.monomer-collections-search input {\n width: 100%;\n max-width: 400px;\n}\n\n.monomer-collection-card-body {\n flex: 1;\n overflow-y: auto;\n padding: 10px 14px;\n min-height: 0;\n}\n\n.monomer-collection-card-actions {\n padding: 0px 14px;\n border-top: 1px solid var(--grey-2);\n display: flex;\n gap: 8px;\n justify-content: flex-end;\n flex-shrink: 0;\n}\n\n.monomer-collection-card-actions .ui-btn {\n font-size: 11px;\n padding: 2px 10px;\n margin: 0;\n}\n\n.monomer-collection-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 4px;\n}\n\n.monomer-collection-tag {\n display: inline-block;\n padding: 2px 8px;\n border-radius: 4px;\n background: var(--grey-1);\n border: 1px solid var(--grey-2);\n font-size: 11px;\n color: var(--grey-5);\n cursor: pointer;\n transition: background 0.15s ease;\n}\n\n.monomer-collection-tag:hover {\n background: var(--blue-1, #e8f0fe);\n border-color: var(--blue-2, #aecbfa);\n}\n\n.monomer-collection-add-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 2px dashed var(--grey-3);\n border-radius: 8px;\n display: flex;\n align-items: center;\n justify-content: center;\n cursor: pointer;\n transition: border-color 0.2s ease, background 0.2s ease;\n}\n\n.monomer-collection-add-card:hover {\n border-color: var(--blue-2, #aecbfa);\n background: var(--blue-1, #e8f0fe);\n}\n\n.monomer-collection-add-card-content {\n text-align: center;\n color: var(--grey-4);\n}\n\n.monomer-collection-add-card-content .grok-icon {\n font-size: 32px;\n margin-bottom: 8px;\n}\n\n.monomer-collection-add-card-content span {\n display: block;\n font-size: 13px;\n}\n\n.monomer-collections-load-more {\n width: 100%;\n display: flex;\n justify-content: center;\n padding: 16px 0;\n}\n\n.monomer-collections-load-more .ui-btn {\n min-width: 200px;\n}\n\n.monomer-collection-empty-state {\n width: 100%;\n text-align: center;\n padding: 60px 20px;\n color: var(--grey-4);\n font-size: 14px;\n}\n","",{version:3,sources:["webpack://./css/monomer-collections.css"],names:[],mappings:"AAAA;EACE,aAAa;EACb,gBAAgB;EAChB,YAAY;AACd;;AAEA;EACE,aAAa;EACb,eAAe;EACf,SAAS;EACT,yBAAyB;AAC3B;;AAEA;EACE,UAAU;EACV,gBAAgB;EAChB,aAAa;EACb,+BAA+B;EAC/B,kBAAkB;EAClB,wBAAwB;EACxB,aAAa;EACb,sBAAsB;EACtB,gBAAgB;EAChB,gCAAgC;AAClC;;AAEA;EACE,0CAA0C;AAC5C;;AAEA;EACE,qBAAqB;EACrB,6BAA6B;AAC/B;;AAEA;EACE,6DAA6D;AAC/D;;AAEA;EACE,2BAA2B;EAC3B,sCAAsC;EACtC,cAAc;AAChB;;AAEA;EACE,eAAe;EACf,gBAAgB;EAChB,oBAAoB;EACpB,SAAS;EACT,gBAAgB;EAChB,uBAAuB;EACvB,mBAAmB;AACrB;;AAEA;EACE,eAAe;EACf,oBAAoB;EACpB,iBAAiB;EACjB,gBAAgB;EAChB,uBAAuB;EACvB,oBAAoB;EACpB,qBAAqB;EACrB,4BAA4B;AAC9B;;AAEA;EACE,aAAa;EACb,eAAe;EACf,QAAQ;EACR,iBAAiB;AACnB;;AAEA;EACE,qBAAqB;EACrB,gBAAgB;EAChB,kBAAkB;EAClB,mBAAmB;EACnB,wCAAwC;EACxC,eAAe;EACf,6BAA6B;AAC/B;;AAEA;EACE,eAAe;EACf,oBAAoB;EACpB,iBAAiB;AACnB;;AAEA;EACE,mBAAmB;AACrB;;AAEA;EACE,WAAW;EACX,gBAAgB;AAClB;;AAEA;EACE,OAAO;EACP,gBAAgB;EAChB,kBAAkB;EAClB,aAAa;AACf;;AAEA;EACE,iBAAiB;EACjB,mCAAmC;EACnC,aAAa;EACb,QAAQ;EACR,yBAAyB;EACzB,cAAc;AAChB;;AAEA;EACE,eAAe;EACf,iBAAiB;EACjB,SAAS;AACX;;AAEA;EACE,aAAa;EACb,eAAe;EACf,QAAQ;AACV;;AAEA;EACE,qBAAqB;EACrB,gBAAgB;EAChB,kBAAkB;EAClB,yBAAyB;EACzB,+BAA+B;EAC/B,eAAe;EACf,oBAAoB;EACpB,eAAe;EACf,iCAAiC;AACnC;;AAEA;EACE,kCAAkC;EAClC,oCAAoC;AACtC;;AAEA;EACE,UAAU;EACV,gBAAgB;EAChB,aAAa;EACb,gCAAgC;EAChC,kBAAkB;EAClB,aAAa;EACb,mBAAmB;EACnB,uBAAuB;EACvB,eAAe;EACf,wDAAwD;AAC1D;;AAEA;EACE,oCAAoC;EACpC,kCAAkC;AACpC;;AAEA;EACE,kBAAkB;EAClB,oBAAoB;AACtB;;AAEA;EACE,eAAe;EACf,kBAAkB;AACpB;;AAEA;EACE,cAAc;EACd,eAAe;AACjB;;AAEA;EACE,WAAW;EACX,aAAa;EACb,uBAAuB;EACvB,eAAe;AACjB;;AAEA;EACE,gBAAgB;AAClB;;AAEA;EACE,WAAW;EACX,kBAAkB;EAClB,kBAAkB;EAClB,oBAAoB;EACpB,eAAe;AACjB",sourcesContent:[".monomer-collections-view {\n padding: 16px;\n overflow-y: auto;\n height: 100%;\n}\n\n.monomer-collections-grid {\n display: flex;\n flex-wrap: wrap;\n gap: 16px;\n align-content: flex-start;\n}\n\n.monomer-collection-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 1px solid var(--grey-2);\n border-radius: 8px;\n background: var(--white);\n display: flex;\n flex-direction: column;\n overflow: hidden;\n transition: box-shadow 0.2s ease;\n}\n\n.monomer-collection-card:hover {\n box-shadow: 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-selected {\n border-color: #ff8c00;\n box-shadow: 0 0 0 1px #ff8c00;\n}\n\n.monomer-collection-card-selected:hover {\n box-shadow: 0 0 0 1px #ff8c00, 0 2px 12px rgba(0, 0, 0, 0.12);\n}\n\n.monomer-collection-card-header {\n padding: 12px 14px 8px 14px;\n border-bottom: 1px solid var(--grey-2);\n flex-shrink: 0;\n}\n\n.monomer-collection-card-title {\n font-size: 14px;\n font-weight: 600;\n color: var(--grey-6);\n margin: 0;\n overflow: hidden;\n text-overflow: ellipsis;\n white-space: nowrap;\n}\n\n.monomer-collection-card-description {\n font-size: 11px;\n color: var(--grey-4);\n margin: 4px 0 0 0;\n overflow: hidden;\n text-overflow: ellipsis;\n display: -webkit-box;\n -webkit-line-clamp: 2;\n -webkit-box-orient: vertical;\n}\n\n.monomer-collection-card-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 3px;\n margin: 4px 0 0 0;\n}\n\n.monomer-collection-card-tag {\n display: inline-block;\n padding: 1px 6px;\n border-radius: 3px;\n background: #e8f0fe;\n border: 1px solid var(--blue-2, #aecbfa);\n font-size: 10px;\n color: var(--blue-3, #4285f4);\n}\n\n.monomer-collection-card-meta {\n font-size: 10px;\n color: var(--grey-3);\n margin: 4px 0 0 0;\n}\n\n.monomer-collections-search {\n margin-bottom: 12px;\n}\n\n.monomer-collections-search input {\n width: 100%;\n max-width: 400px;\n}\n\n.monomer-collection-card-body {\n flex: 1;\n overflow-y: auto;\n padding: 10px 14px;\n min-height: 0;\n}\n\n.monomer-collection-card-actions {\n padding: 0px 14px;\n border-top: 1px solid var(--grey-2);\n display: flex;\n gap: 8px;\n justify-content: flex-end;\n flex-shrink: 0;\n}\n\n.monomer-collection-card-actions .ui-btn {\n font-size: 11px;\n padding: 2px 10px;\n margin: 0;\n}\n\n.monomer-collection-tags {\n display: flex;\n flex-wrap: wrap;\n gap: 4px;\n}\n\n.monomer-collection-tag {\n display: inline-block;\n padding: 2px 8px;\n border-radius: 4px;\n background: var(--grey-1);\n border: 1px solid var(--grey-2);\n font-size: 11px;\n color: var(--grey-5);\n cursor: pointer;\n transition: background 0.15s ease;\n}\n\n.monomer-collection-tag:hover {\n background: var(--blue-1, #e8f0fe);\n border-color: var(--blue-2, #aecbfa);\n}\n\n.monomer-collection-add-card {\n width: 20%;\n min-width: 240px;\n height: 300px;\n border: 2px dashed var(--grey-3);\n border-radius: 8px;\n display: flex;\n align-items: center;\n justify-content: center;\n cursor: pointer;\n transition: border-color 0.2s ease, background 0.2s ease;\n}\n\n.monomer-collection-add-card:hover {\n border-color: var(--blue-2, #aecbfa);\n background: var(--blue-1, #e8f0fe);\n}\n\n.monomer-collection-add-card-content {\n text-align: center;\n color: var(--grey-4);\n}\n\n.monomer-collection-add-card-content .grok-icon {\n font-size: 32px;\n margin-bottom: 8px;\n}\n\n.monomer-collection-add-card-content span {\n display: block;\n font-size: 13px;\n}\n\n.monomer-collections-load-more {\n width: 100%;\n display: flex;\n justify-content: center;\n padding: 16px 0;\n}\n\n.monomer-collections-load-more .ui-btn {\n min-width: 200px;\n}\n\n.monomer-collection-empty-state {\n width: 100%;\n text-align: center;\n padding: 60px 20px;\n color: var(--grey-4);\n font-size: 14px;\n}\n"],sourceRoot:""}]);const a=s},857(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".scatter_plot_link {\n right: 10px;\n}\n\n.cliffs_div {\n flex-grow: initial!important;\n justify-content: flex-end;\n flex-wrap: wrap;\n}\n\n.cliffs_grid {\n margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n right: 10px;\n}\n\n.cliffs_div {\n flex-grow: initial!important;\n justify-content: flex-end;\n flex-wrap: wrap;\n}\n\n.cliffs_grid {\n margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017(e,t,n){"use strict";n.d(t,{A:()=>a});var i=n(1354),o=n.n(i),r=n(6314),s=n.n(r)()(o());s.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n min-width: 220px;\n width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n min-width: 220px;\n width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314(e){"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map(function(t){var n="",i=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),i&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),i&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n}).join("")},t.i=function(e,n,i,o,r){"string"==typeof e&&(e=[[null,e,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);i&&s[u[0]]||(void 0!==r&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=r),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),o&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=o):u[4]="".concat(o)),t.push(u))}},t}},1354(e){"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),o="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),r="/*# ".concat(o," */");return[t].concat([r]).join("\n")}return[t].join("\n")}},2017(e){"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var i,o,r;if(Array.isArray(t)){if((i=t.length)!=n.length)return!1;for(o=i;0!==o--;)if(!e(t[o],n[o]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((i=(r=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(o=i;0!==o--;)if(!Object.prototype.hasOwnProperty.call(n,r[o]))return!1;for(o=i;0!==o--;){var s=r[o];if(!e(t[s],n[s]))return!1}return!0}return t!=t&&n!=n}},9982(e,t,n){var i;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,i,o,r){for(var s,a,l,c,u,h,d,m,p,g,f,y,b;r>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],m=n[7],g=0;g<16;g++)f=o+4*g,e[g]=(255&i[f])<<24|(255&i[f+1])<<16|(255&i[f+2])<<8|255&i[f+3];for(g=16;g<64;g++)y=((p=e[g-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,b=((p=e[g-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,e[g]=(y+e[g-7]|0)+(b+e[g-16]|0);for(g=0;g<64;g++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(m+(t[g]+e[g]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,m=d,d=h,h=u,u=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=m,o+=64,r-=64}return o}var i=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[i++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(i=n(this.temp,this.state,e,i,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[i++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,i=this.bufferLength,o=t/536870912|0,r=t<<3,s=t%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=o>>>24&255,this.buffer[s-7]=o>>>16&255,this.buffer[s-6]=o>>>8&255,this.buffer[s-5]=o>>>0&255,this.buffer[s-4]=r>>>24&255,this.buffer[s-3]=r>>>16&255,this.buffer[s-2]=r>>>8&255,this.buffer[s-1]=r>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=i;var o=function(){function e(e){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new i).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function r(e){var t=(new i).update(e),n=t.digest();return t.clean(),n}function s(e,t){var n=new o(e).update(t),i=n.digest();return n.clean(),i}function a(e,t,n,i){var o=i[0];if(0===o)throw new Error("hkdf: cannot expand more");t.reset(),o>1&&t.update(e),n&&t.update(n),t.update(i),t.finish(e),i[0]++}e.HMAC=o,e.hash=r,e.default=r,e.hmac=s;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,i){void 0===t&&(t=l),void 0===i&&(i=32);for(var r=new Uint8Array([1]),c=s(t,e),u=new o(c),h=new Uint8Array(u.digestLength),d=h.length,m=new Uint8Array(i),p=0;p<i;p++)d===h.length&&(a(h,u,n,r),d=0),m[p]=h[d++];return u.clean(),h.fill(0),r.fill(0),m},e.pbkdf2=function(e,t,n,i){for(var r=new o(e),s=r.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),u=new Uint8Array(i),h=0;h*s<i;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,r.reset(),r.update(t),r.update(a),r.finish(c);for(var m=0;m<s;m++)l[m]=c[m];for(m=2;m<=n;m++){r.reset(),r.update(c).finish(c);for(var p=0;p<s;p++)l[p]^=c[p]}for(m=0;m<s&&h*s+m<i;m++)u[h*s+m]=l[m]}for(h=0;h<s;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return r.clean(),u}}(t);var o=t.default;for(var r in t)o[r]=t[r];"object"==typeof e.exports?e.exports=o:void 0===(i=function(){return o}.call(t,n,t,e))||(e.exports=i)}()},2787(e,t,n){"use strict";n.d(t,{I:()=>o});const i=new Uint32Array(65536),o=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,o=t.length,r=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[e.charCodeAt(c)]|=1<<c;for(c=0;c<o;c++){let e=i[t.charCodeAt(c)];const n=e|a;e|=(e&s)+s^s,a|=~(e|s),s&=e,a&r&&l++,s&r&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,o=e.length,r=[],s=[],a=Math.ceil(n/32),l=Math.ceil(o/32);for(let e=0;e<a;e++)s[e]=-1,r[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,o)+u;for(let t=u;t<h;t++)i[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],o=s[e/32|0]>>>e&1,c=r[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),m=l&h;d>>>31^o&&(s[e/32|0]^=1<<e),m>>>31^c&&(r[e/32|0]^=1<<e),d=d<<1|o,m=m<<1|c,l=m|~(u|d),a=d&u}for(let t=u;t<h;t++)i[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,m=Math.min(32,o-d)+d;for(let t=d;t<m;t++)i[e.charCodeAt(t)]|=1<<t;let p=o;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],a=s[e/32|0]>>>e&1,l=r[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let m=u|~(d|h),g=h&d;p+=m>>>o-1&1,p-=g>>>o-1&1,m>>>31^a&&(s[e/32|0]^=1<<e),g>>>31^l&&(r[e/32|0]^=1<<e),m=m<<1|a,g=g<<1|l,h=g|~(c|m),u=m&c}for(let t=d;t<m;t++)i[e.charCodeAt(t)]=0;return p})(e,t)}},9937(e){e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782(e,t){t.assign=function(e){e=e||{};var t,n,i,o=Array.prototype.slice.call(arguments).slice(1);for(t=0,i=o.length;t<i;t++)if(o[t])for(n in o[t])e[n]=o[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,i=e.order,o=e.size,r={},s=new Float32Array(10*i),a=new Float32Array(3*o);return n=0,e.forEachNode(function(e,t){r[e]=n,s[n]=t.x,s[n+1]=t.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=t.size||1,s[n+9]=t.fixed?1:0,n+=10}),n=0,e.forEachEdge(function(e,i,o,l,c,u,h){var d=r[o],m=r[l],p=t(e,i,o,l,c,u,h);s[d+6]+=p,s[m+6]+=p,a[n]=d,a[n+1]=m,a[n+2]=p,n+=3}),{nodes:s,edges:a}},t.assignLayoutChanges=function(e,t,n){var i=0;e.updateEachNodeAttributes(function(e,o){return o.x=t[i],o.y=t[i+1],i+=10,n?n(e,o):o})},t.readGraphPositions=function(e,t){var n=0;e.forEachNode(function(e,i){t[n]=i.x,t[n+1]=i.y,n+=10})},t.collectLayoutChanges=function(e,t,n){for(var i=e.nodes(),o={},r=0,s=0,a=t.length;r<a;r+=10){if(n){var l=Object.assign({},e.getNodeAttributes(i[s]));l.x=t[r],l.y=t[r+1],l=n(i[s],l),o[i[s]]={x:l.x,y:l.y}}else o[i[s]]={x:t[r],y:t[r+1]};s++}return o},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),i=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),o=new Worker(i);return t.revokeObjectURL(i),o}},8903(e,t,n){var i=n(1736),o=n(8153).Fd,r=n(2561),s=n(1782),a=n(9937);function l(e,t,n){if(!i(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=o("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,h=s.assign({},a,n.settings),d=s.validateSettings(h);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var m,p=s.graphToByteArrays(t,c);for(m=0;m<l;m++)r(h,p.nodes,p.edges);if(!e)return s.collectLayoutChanges(t,p.nodes);s.assignLayoutChanges(t,p.nodes,u)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=c},2561(e){var t=10;e.exports=function(e,n,i){var o,r,s,a,l,c,u,h,d,m,p,g,f,y,b,v,w,C,A,S,x,E,M,T=n.length,I=i.length,L=e.adjustSizes,_=e.barnesHutTheta*e.barnesHutTheta,N=[];for(s=0;s<T;s+=t)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(e.outboundAttractionDistribution){for(p=0,s=0;s<T;s+=t)p+=n[s+6];p/=T/t}if(e.barnesHutOptimize){var P,R,$,O=1/0,k=-1/0,H=1/0,B=-1/0;for(s=0;s<T;s+=t)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),H=Math.min(H,n[s+1]),B=Math.max(B,n[s+1]);var F=k-O,D=B-H;for(F>D?B=(H-=(F-D)/2)+F:k=(O-=(D-F)/2)+D,N[0]=-1,N[1]=(O+k)/2,N[2]=(H+B)/2,N[3]=Math.max(k-O,B-H),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,o=1,s=0;s<T;s+=t)for(r=0,$=3;;){if(!(N[r+5]>=0)){if(N[r+0]<0){N[r+0]=s;break}if(N[r+5]=9*o,h=N[r+3]/2,N[(d=N[r+5])+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]-h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+h,N[d+2]=N[r+2]+h,N[d+3]=h,N[d+4]=N[r+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,o+=4,P=n[N[r+0]+0]<N[r+1]?n[N[r+0]+1]<N[r+2]?N[r+5]:N[r+5]+9:n[N[r+0]+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+6]=n[N[r+0]+6],N[r+7]=n[N[r+0]+0],N[r+8]=n[N[r+0]+1],N[P+0]=N[r+0],N[r+0]=-1,P===(R=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27)){if($--){r=P;continue}$=3;break}N[R+0]=s;break}P=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+7]=(N[r+7]*N[r+6]+n[s+0]*n[s+6])/(N[r+6]+n[s+6]),N[r+8]=(N[r+8]*N[r+6]+n[s+1]*n[s+6])/(N[r+6]+n[s+6]),N[r+6]+=n[s+6],r=P}}if(e.barnesHutOptimize){for(g=e.scalingRatio,s=0;s<T;s+=t)for(r=0;;)if(N[r+5]>=0){if(v=Math.pow(n[s+0]-N[r+7],2)+Math.pow(n[s+1]-N[r+8],2),4*(m=N[r+3])*m/v<_){if(f=n[s+0]-N[r+7],y=n[s+1]-N[r+8],!0===L?v>0?(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*N[r+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w),(r=N[r+4])<0)break;continue}r=N[r+5]}else if((c=N[r+0])>=0&&c!==s&&(v=(f=n[s+0]-n[c+0])*f+(y=n[s+1]-n[c+1])*y,!0===L?v>0?(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w)),(r=N[r+4])<0)break}else for(g=e.scalingRatio,a=0;a<T;a+=t)for(l=0;l<a;l+=t)f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===L?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8])>0?(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):v<0&&(w=100*g*n[a+6]*n[l+6],n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):(v=Math.sqrt(f*f+y*y))>0&&(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,g=e.scalingRatio,s=0;s<T;s+=t)w=0,f=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=g*n[s+6]*d):v>0&&(w=g*n[s+6]*d/v),n[s+2]-=f*w,n[s+3]-=y*w;for(g=1*(e.outboundAttractionDistribution?p:1),u=0;u<I;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===L?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-g*b/n[a+6]):v>0&&(w=-g*b)):(v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-g*b/n[a+6]):(v=1,w=-g*b)),v>0&&(n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);if(!0===L)for(s=0;s<T;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=M);else for(s=0;s<T;s+=t)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=M);return{}}},8153(e,t){function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},i=function(e){return void 0===e?t:e};"function"==typeof t&&(i=t);var o=function(t){return i(t[e])},r=function(){return i(void 0)};return"string"==typeof e?(n.fromAttributes=o,n.fromGraph=function(e,t){return o(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return o(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var o=t.extremities(n);return i(e(n,t.getEdgeAttributes(n),o[0],o[1],t.getNodeAttributes(o[0]),t.getNodeAttributes(o[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,o,r,s,a,l){return i(e(t,n,o,r,s,a,l))},n.fromPartialEntry=function(t,n,o,r){return i(e(t,n,o,r))},n.fromMinimalEntry=function(t,n){return i(e(t,n))}):(n.fromAttributes=r,n.fromGraph=r,n.fromEntry=r,n.fromMinimalEntry=r),n}(e,n)}},1736(e){e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,i(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function i(e,t){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},i(e,t)}function o(e,t,n){return o=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],function(){})),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var o=[null];o.push.apply(o,t);var r=new(Function.bind.apply(e,o));return n&&i(r,n.prototype),r},o.apply(null,arguments)}function r(e){var t="function"==typeof Map?new Map:void 0;return r=function(e){if(null===e||(r=e,-1===Function.toString.call(r).indexOf("[native code]")))return e;var r;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,s)}function s(){return o(e,arguments,n(this).constructor)}return s.prototype=Object.create(e.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,e)},r(e)}function s(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var i in arguments[t])e[i]=arguments[t][i];return e};function l(e,t,n,i){var o=e._nodes.get(t),r=null;return o?r="mixed"===i?o.out&&o.out[n]||o.undirected&&o.undirected[n]:"directed"===i?o.out&&o.out[n]:o.undirected&&o.undirected[n]:r}function c(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function h(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(e,t,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(e,t,i)}function m(e){return!(!c(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var p,g={exports:{}},f="object"==typeof Reflect?Reflect:null,y=f&&"function"==typeof f.apply?f.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};p=f&&"function"==typeof f.ownKeys?f.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var b=Number.isNaN||function(e){return e!=e};function v(){v.init.call(this)}g.exports=v,g.exports.once=function(e,t){return new Promise(function(n,i){function o(n){e.removeListener(t,r),i(n)}function r(){"function"==typeof e.removeListener&&e.removeListener("error",o),n([].slice.call(arguments))}L(e,t,r,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&L(e,"error",t,{once:!0})}(e,o)})},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function A(e){return void 0===e._maxListeners?v.defaultMaxListeners:e._maxListeners}function S(e,t,n,i){var o,r,s,a;if(C(n),void 0===(r=e._events)?(r=e._events=Object.create(null),e._eventsCount=0):(void 0!==r.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),r=e._events),s=r[t]),void 0===s)s=r[t]=n,++e._eventsCount;else if("function"==typeof s?s=r[t]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(o=A(e))>0&&s.length>o&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=e,l.type=t,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return e}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(e,t,n){var i={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},o=x.bind(i);return o.listener=n,i.wrapFn=o,o}function M(e,t,n){var i=e._events;if(void 0===i)return[];var o=i[t];return void 0===o?[]:"function"==typeof o?n?[o.listener||o]:[o]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(o):I(o,o.length)}function T(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(e,t){for(var n=new Array(t),i=0;i<t;++i)n[i]=e[i];return n}function L(e,t,n,i){if("function"==typeof e.on)i.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,function o(r){i.once&&e.removeEventListener(t,o),n(r)})}}function _(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");w=e}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var i="error"===e,o=this._events;if(void 0!==o)i=i&&void 0===o.error;else if(!i)return!1;if(i){var r;if(t.length>0&&(r=t[0]),r instanceof Error)throw r;var s=new Error("Unhandled error."+(r?" ("+r.message+")":""));throw s.context=r,s}var a=o[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,t)}return!0},v.prototype.addListener=function(e,t){return S(this,e,t,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(e,t){return S(this,e,t,!0)},v.prototype.once=function(e,t){return C(t),this.on(e,E(this,e,t)),this},v.prototype.prependOnceListener=function(e,t){return C(t),this.prependListener(e,E(this,e,t)),this},v.prototype.removeListener=function(e,t){var n,i,o,r,s;if(C(t),void 0===(i=this._events))return this;if(void 0===(n=i[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete i[e],i.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(o=-1,r=n.length-1;r>=0;r--)if(n[r]===t||n[r].listener===t){s=n[r].listener,o=r;break}if(o<0)return this;0===o?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,o),1===n.length&&(i[e]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",e,s||t)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(e){var t,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var o,r=Object.keys(n);for(i=0;i<r.length;++i)"removeListener"!==(o=r[i])&&this.removeAllListeners(o);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(i=t.length-1;i>=0;i--)this.removeListener(e,t[i]);return this},v.prototype.listeners=function(e){return M(this,e,!0)},v.prototype.rawListeners=function(e){return M(this,e,!1)},v.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):T.call(e,t)},v.prototype.listenerCount=T,v.prototype.eventNames=function(){return this._eventsCount>0?p(this._events):[]},"undefined"!=typeof Symbol&&(_.prototype[Symbol.iterator]=function(){return this}),_.of=function(){var e=arguments,t=e.length,n=0;return new _(function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}})},_.empty=function(){return new _(function(){return{done:!0}})},_.fromSequence=function(e){var t=0,n=e.length;return new _(function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}})},_.is=function(e){return e instanceof _||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=_,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var R=N,$=P,O=$.ARRAY_BUFFER_SUPPORT,k=$.SYMBOL_SUPPORT,H=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?R.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},B=H,F=function(e,t){for(var n,i=arguments.length>1?t:1/0,o=i!==1/0?new Array(i):[],r=0,s=B(e);;){if(r===i)return o;if((n=s.next()).done)return r!==t&&(o.length=r),o;o[r++]=n.value}},D=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(r(Error)),G=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D),V=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D),q=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(D);function j(e,t){this.key=e,this.attributes=t,this.clear()}function U(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function z(e,t,n,i,o){this.key=t,this.attributes=o,this.undirected=e,this.source=n,this.target=i}function Y(e,t,n,i,o,r,s){var a,l,c,u;if(i=""+i,0===n){if(!(a=e._nodes.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" node in the graph.'));c=o,u=r}else if(3===n){if(o=""+o,!(l=e._edges.get(o)))throw new V("Graph.".concat(t,': could not find the "').concat(o,'" edge in the graph.'));var h=l.source.key,d=l.target.key;if(i===h)a=l.target;else{if(i!==d)throw new V("Graph.".concat(t,': the "').concat(i,'" node is not attached to the "').concat(o,'" edge (').concat(h,", ").concat(d,")."));a=l.source}c=r,u=s}else{if(!(l=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=o,u=r}return[a,c,u]}j.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},W.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,i=this.target.key;this.source[e][i]=this,this.undirected&&n===i||(this.target[t][n]=this)},z.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,i=this.target.key;this.undirected&&(e=t="undirected");var o=this.source[e],r=o[i];if(void 0===r)return o[i]=this,void(this.undirected&&n===i||(this.target[t][n]=this));r.previous=this,this.next=r,o[i]=this,this.target[t][n]=this},z.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][t],delete this.target[i][e]},z.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[i][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[i][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){return Y(this,t,n,e,i)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return s.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o,r){var s=Y(this,t,n,e,i,o,r),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new G("Graph.".concat(t,": updater should be a function."));var u=a.attributes,h=c(u[l]);return u[l]=h,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if(!c(a))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],l=r[1];if(!c(l))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r=Y(this,t,n,e,i,o),s=r[0],a=r[1];if("function"!=typeof a)throw new G("Graph.".concat(t,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes[i]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,r=""+arguments[1];if(!(i=l(this,o,r,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(r,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]=o,this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof o)throw new G("Graph.".concat(t,": updater should be a function."));return r.attributes[i]=o(r.attributes[i]),this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new G("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,i),this.emit("edgeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new q("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new q("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new q("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new G("Graph.".concat(t,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var e=arguments,t=null,n=-1;return new X(function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i})},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var o=!1;for(var r in t)if(r!==i){var s=t[r];if(o=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&o)return s.key}}function ne(e,t,n,i){var o,r,s,a=!1;for(var l in t)if(l!==i){o=t[l];do{if(r=o.source,s=o.target,a=n(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected),e&&a)return o.key;o=o.next}while(void 0!==o)}}function ie(e,t){var n,i=Object.keys(e),o=i.length,r=0;return new N(function(){do{if(n)n=n.next;else{if(r>=o)return{done:!0};var s=i[r++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}})}function oe(e,t,n,i){var o=t[n];if(o){var r=o.source,s=o.target;return i(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected)&&e?o.key:void 0}}function re(e,t,n,i){var o=t[n];if(o){var r=!1;do{if(r=i(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&r)return o.key;o=o.next}while(void 0!==o)}}function se(e,t){var n=e[t];return void 0!==n.next?new N(function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}}):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var u=r,h=u.key,d=u.attributes,m=u.source,p=u.target;if(l=i(h,d,m.key,p.key,m.attributes,p.attributes,r.undirected),e&&l)return h}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function me(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new he;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function pe(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),m=i.type;!0!==(r=d.next()).done;){var p=!1;if(s=r.value,"undirected"!==m)for(a in l=s.out){c=l[a];do{if(u=c.target,p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==m)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!p&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new G('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new G("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new G('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new G("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new G("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new G("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new q("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var m=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,m&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,m&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Ee(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new G("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new q("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;p||(p=Se(e,r,{}),v=!0,r===s&&(g=p,w=!0)),g||(g=Se(e,s,{}),w=!0),d=new z(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new G("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new G('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new G("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?U:W;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new G("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new q("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new G('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new q('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new G('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new G('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new G("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new G("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new G("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new G("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new G("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new G("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new G("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new G("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new G("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new G("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new G("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new G("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new G("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new G("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new G("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new G("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var p=s,g=p.source,f=p.target,y=p.attributes,b=p.undirected,v=void 0===b?m:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach(function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)}),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new q('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new q("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new q("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach(function(e,t){n[t]=e.attributes});var i={},o={};this._edges.forEach(function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[u]?o[u]=0:o[u]++,a+="".concat(o[u],". ")):a+="[".concat(n,"]: "),i[a+=u]=e.attributes});var r={};for(var s in this)this.hasOwnProperty(s)&&!Ce.has(s)&&"function"!=typeof this[s]&&"symbol"!==e(s)&&(r[s]=this[s]);return r.attributes=this._attributes,r.nodes=n,r.edges=i,h(r,"constructor",this.constructor),r},i}(g.exports.EventEmitter);"undefined"!=typeof Symbol&&(Te.prototype[Symbol.for("nodejs.util.inspect.custom")]=Te.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach(function(e){["add","merge","update"].forEach(function(t){var n=e.name(t),i="add"===t?xe:Ee;e.generateKey?Te.prototype[n]=function(o,r,s){return i(this,n,!0,"undirected"===(e.type||this.type),null,o,r,s,"update"===t)}:Te.prototype[n]=function(o,r,s,a){return i(this,n,!1,"undirected"===(e.type||this.type),o,r,s,a,"update"===t)}})}),function(e){K.forEach(function(t){var n=t.name,i=t.attacher;i(e,n("Node"),0),i(e,n("Source"),1),i(e,n("Target"),2),i(e,n("Opposite"),3)})}(Te),function(e){Z.forEach(function(t){var n=t.name,i=t.attacher;i(e,n("Edge"),"mixed"),i(e,n("DirectedEdge"),"directed"),i(e,n("UndirectedEdge"),"undirected")})}(Te),function(e){ee.forEach(function(t){!function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):F(e._edges.keys(),e._edges.size);for(var n,i,o="undirected"===t?e.undirectedSize:e.directedSize,r=new Array(o),s="undirected"===t,a=e._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(r[l++]=i.key);return r}(this,i);if(1===arguments.length){e=""+e;var r=this._nodes.get(e);if(void 0===r)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,i){var o=[];return le(!1,e,t,n,i,function(e){o.push(e)}),o}(this.multi,"mixed"===i?this.type:i,o,r)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i,o){var r=[];return ce(!1,e,t,n,i,o,function(e){r.push(e)}),r}(i,this.multi,o,s,t)}throw new G("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return ae(!1,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!1,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return ce(!1,i,this.multi,o,a,t,n)}throw new G("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var o=0;"directed"!==i&&(o+=this.undirectedSize),"undirected"!==i&&(o+=this.directedSize),e=new Array(o);var s=0;t.push(function(t,i,o,r,a,l,c){e[s++]=n(t,i,o,r,a,l,c)})}else e=[],t.push(function(t,i,o,r,s,a,l){e.push(n(t,i,o,r,s,a,l))});return this[r].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push(function(e,i,o,r,s,a,l){t(e,i,o,r,s,a,l)&&n.push(e)}),this[r].apply(this,e),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new G("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new G("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var i=t;return n.push(function(t,n,o,r,s,a,l){i=e(i,t,n,o,r,s,a,l)}),this[r].apply(this,n),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return ae(!0,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return le(!0,this.multi,"mixed"===i?this.type:i,o,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return ce(!0,i,this.multi,o,a,t,n)}throw new G("Graph.".concat(r,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push(function(e,n,i,o,r,s,a){return t(e,n,i,o,r,s,a)}),!!this[r].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push(function(e,n,i,o,r,s,a){return!t(e,n,i,o,r,s,a)}),!this[r].apply(this,e)}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,i="undirected"===t,o=e._edges.values();return new N(function(){for(var e,t;;){if((e=o.next()).done)return e;if(t=e.value,!n||t.undirected===i)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}})}(this,i);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var i=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(i=Q(i,ie(n.in))),"in"!==t&&void 0!==n.out&&(i=Q(i,ie(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(i=Q(i,ie(n.undirected))),i}(i,o,n)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(r,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i){var o=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&i in n.in&&(o=Q(o,se(n.in,i))),void 0!==n.out&&"in"!==t&&i in n.out&&(t||n.key!==i)&&(o=Q(o,se(n.out,i)))),"directed"!==e&&void 0!==n.undirected&&i in n.undirected&&(o=Q(o,se(n.undirected,i))),o}(i,o,s,t)}throw new G("Graph.".concat(r,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)})}(Te),function(e){ue.forEach(function(t){(function(e,t){var n=t.name,i=t.type,o=t.direction;e.prototype[n]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var i=[];return me(!1,e,t,n,function(e){i.push(e)}),i}("mixed"===i?this.type:i,o,t)}})(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[r]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));me(!1,"mixed"===i?this.type:i,o,n,t)}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(e,t){var n=[];return this[r](e,function(e,i){n.push(t(e,i))}),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[r](e,function(e,i){t(e,i)&&n.push(e)}),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(e,t,n){if(arguments.length<3)throw new G("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[r](e,function(e,n){i=t(i,e,n)}),i}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n[0].toUpperCase()+n.slice(1,-1),s="find"+r;e.prototype[s]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return me(!0,"mixed"===i?this.type:i,o,n,t)}};var a="some"+r;e.prototype[a]=function(e,t){return!!this[s](e,t)};var l="every"+r;e.prototype[l]=function(e,t){return!this[s](e,function(e,n){return!t(e,n)})}}(e,t),function(e,t){var n=t.name,i=t.type,o=t.direction,r=n.slice(0,-1)+"Entries";e.prototype[r]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(r,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return pe(null,n,n.undirected);if("string"==typeof t)return pe(null,n,n[t])}var i=N.empty(),o=new he;return"undirected"!==e&&("out"!==t&&(i=Q(i,pe(o,n,n.in))),"in"!==t&&(i=Q(i,pe(o,n,n.out)))),"directed"!==e&&(i=Q(i,pe(o,n,n.undirected))),i}("mixed"===i?this.type:i,o,t)}}(e,t)})}(Te);var Ie=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new G("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new G('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Le=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new G("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new G('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),_e=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Te),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new G('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te),Pe=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new G("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new G('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Te);function Re(e){e.from=function(t,n){var i=a({},t.options,n),o=new e(i);return o.import(t),o}}return Re(Te),Re(Ie),Re(Le),Re(_e),Re(Ne),Re(Pe),Te.Graph=Te,Te.DirectedGraph=Ie,Te.UndirectedGraph=Le,Te.MultiGraph=_e,Te.MultiDirectedGraph=Ne,Te.MultiUndirectedGraph=Pe,Te.InvalidArgumentsGraphError=G,Te.NotFoundGraphError=V,Te.UsageGraphError=q,Te}()},944(e,t){"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var i=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var i=0,o=e.length,r=t.length,s=Math.floor(Math.max(o,r)/2)-1,a=new Array(o),l=new Array(r),c=0;c<o;c++)for(var u=Math.max(0,c-s);u<=Math.min(r,c+s+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++i,a[c]=l[u]=!0;break}if(0===i)return 0;var h=0,d=0;for(c=0;c<o;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(i/o+i/r+(i-(h/=2))/i)/3}(e,t,n),o=0;if(i>.7){for(var r=Math.min(e.length,t.length),s=0;e[s]===t[s]&&s<4&&s<r;)++o,s++;i+=.1*o*(1-i)}return i}},7106(e){"use strict";var t=e.exports=function(e,t,i){"function"==typeof t&&(i=t,t={}),n(t,"function"==typeof(i=t.cb||i)?i:i.pre||function(){},i.post||function(){},e,"",e)};function n(e,o,r,s,a,l,c,u,h,d){if(s&&"object"==typeof s&&!Array.isArray(s)){for(var m in o(s,a,l,c,u,h,d),s){var p=s[m];if(Array.isArray(p)){if(m in t.arrayKeywords)for(var g=0;g<p.length;g++)n(e,o,r,p[g],a+"/"+m+"/"+g,l,a,m,s,g)}else if(m in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,o,r,p[f],a+"/"+m+"/"+i(f),l,a,m,s,f)}else(m in t.keywords||e.allKeys&&!(m in t.skipKeywords))&&n(e,o,r,p,a+"/"+m,l,a,m,s)}r(s,a,l,c,u,h,d)}}function i(e){return e.replace(/~/g,"~0").replace(/\//g,"~1")}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072(e){"use strict";var t=[];function n(e){for(var n=-1,i=0;i<t.length;i++)if(t[i].identifier===e){n=i;break}return n}function i(e,i){for(var r={},s=[],a=0;a<e.length;a++){var l=e[a],c=i.base?l[0]+i.base:l[0],u=r[c]||0,h="".concat(c," ").concat(u);r[c]=u+1;var d=n(h),m={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(m);else{var p=o(m,i);i.byIndex=a,t.splice(a,0,{identifier:h,updater:p,references:1})}s.push(h)}return s}function o(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,o){var r=i(e=e||[],o=o||{});return function(e){e=e||[];for(var s=0;s<r.length;s++){var a=n(r[s]);t[a].references--}for(var l=i(e,o),c=0;c<r.length;c++){var u=n(r[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}r=l}}},7659(e){"use strict";var t={};e.exports=function(e,n){var i=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540(e){"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056(e,t,n){"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825(e){"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var o=void 0!==n.layer;o&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,o&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var r=n.sourceMap;r&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(r))))," */")),t.styleTagTransform(i,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113(e){"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},8012(e,t,n){"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>jo,PackageFunctions:()=>xs,SeqActivityCliffsEditor:()=>zo,SeqPaletteCustom:()=>Es,SequenceSpaceEditor:()=>Wo,SplitToMonomersEditor:()=>Uo,SubsequenceSearchTopMenu:()=>qr,_package:()=>As,activityCliffs:()=>dr,addCopyMenu:()=>ls,alignSequences:()=>Tr,applyNumberingScheme:()=>lr,bilnSequenceCellRenderer:()=>Xo,bioSubstructureFilter:()=>Qr,bioSubstructureFilterTest:()=>es,compositionAnalysis:()=>Lr,compositionAnalysisWidget:()=>er,convertColumnAction:()=>Rr,convertDialog:()=>Pr,customSequenceCellRenderer:()=>Yo,demoBioActivityCliffs:()=>hs,demoBioAtomicLevel:()=>ds,demoBioSequenceSpace:()=>us,demoBioSimilarityDiversity:()=>cs,detectMacromoleculeProbe:()=>fs,diversitySearchTopMenu:()=>Gr,diversitySearchViewer:()=>Dr,fastaSequenceCellRenderer:()=>Ko,getBioLib:()=>Do,getHelmMonomers:()=>Hr,getMolFromHelm:()=>bs,getMonomerLibHelper:()=>Oo,getRegion:()=>sr,getRegionApp:()=>is,getRegionHelmApp:()=>os,getRegionPanel:()=>Vo,getRegionTopMenu:()=>ar,getSeqHandler:()=>Go,getSeqHelper:()=>ys,helmPreprocessingFunction:()=>fr,importBam:()=>Nr,importFasta:()=>_r,initBio:()=>ko,libraryPanel:()=>qo,longSeqTableFasta:()=>ss,longSeqTableHelm:()=>as,longSeqTableSeparator:()=>rs,macroMolColumnPropertyPanel:()=>Qo,macromoleculeDifferenceCellRenderer:()=>nr,macromoleculePreprocessingFunction:()=>gr,manageAnnotations:()=>ur,manageLibrariesView:()=>zr,manageMonomerLibraries:()=>Wr,manageMonomerLibrariesView:()=>Kr,manageMonomerLibrariesViewTreeBrowser:()=>Zr,manageMonomersView:()=>Yr,matchWithMonomerLibrary:()=>Fo,moleculeToHelmSingle:()=>wr,moleculesToHelmTopMenu:()=>vr,monomerCellRenderer:()=>$r,monomerCollectionsApp:()=>Xr,monomerInfoPanel:()=>tr,multipleSequenceAlignmentDialog:()=>Mr,pepseaMsa:()=>Ir,refineNotationProviderForBiln:()=>Jo,saveAsFasta:()=>Jr,scanLiabilities:()=>cr,sdfToJsonLib:()=>ms,searchSubsequenceEditor:()=>Vr,separatorSequenceCellRenderer:()=>Zo,seq2atomic:()=>ps,seqActivityCliffsInitFunction:()=>mr,seqActivityCliffsTransform:()=>pr,seqIdentity:()=>gs,sequence3dStructureWidget:()=>Er,sequenceAlignment:()=>ir,sequenceColumnInput:()=>hr,sequenceIdentityScoring:()=>jr,sequenceSimilarityScoring:()=>Ur,sequenceSpaceTopMenu:()=>yr,sequenceSpaceTransform:()=>br,sequenceTooltip:()=>Ho,similaritySearchTopMenu:()=>Fr,similaritySearchViewer:()=>Br,splitToMonomersTopMenu:()=>kr,standardiseMonomerLibrary:()=>Bo,test1:()=>Ms,testDetectMacromolecule:()=>Or,toAtomicLevel:()=>Cr,toAtomicLevelAction:()=>Ar,toAtomicLevelPanel:()=>Sr,toAtomicLevelSingleSeq:()=>xr,vdRegionsViewer:()=>rr,webLogoAggApp:()=>ns,webLogoLargeApp:()=>ts,webLogoViewer:()=>or});var i,o=n(4328),r=n(7389),s=n(6082),a=n(684),l=n(9039);!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(i||(i={}));var c=n(1858),u=n(5072),h=n.n(u),d=n(7825),m=n.n(d),p=n(7659),g=n.n(p),f=n(5056),y=n.n(f),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(7939),S={};S.styleTagTransform=C(),S.setAttributes=y(),S.insert=g().bind(null,"head"),S.domAPI=m(),S.insertStyleElement=v(),h()(A.A,S),A.A&&A.A.locals&&A.A.locals;var x=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};let E=null,M=null;function T(e,t){return e&&""!=e?e:t}n(2780);class I{constructor(){this.learningRate={uiName:"Learninig Rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min Distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random Seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter(),null==E))return null;let e=null;return"info"in E&&(e=E.info),e?T(e.description,T(e.vendor,"No GPU description available")):"No GPU description available"})}().then(e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)})}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const _="MCL";s.SEMTYPE.MOLECULE,s.SEMTYPE.MACROMOLECULE;class N{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach(n=>{null!=e[n].value&&(t[n]=e[n].value)}),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=r.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=r.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[l.c.UMAP,l.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=r.inputs([]),this.dbScanSettingsDiv=r.inputs([]),this.preprocessingFuncSettingsDiv=r.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[l.c.UMAP]:new I,[l.c.T_SNE]:new L},this.dbScanParams=new N,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(_);const t=s.Func.find({tags:[a.GP]}),n=s.Func.find({meta:{role:a.GP}});Array.from(new Set([...t,...n])).forEach(e=>{const t=e.options.get(a.n3)??"",n=e.friendlyName??e.name,i=e.options.get(a.C0)??"",o=e.options.get(a._X)??"",r=e.options.get(a.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})}),this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let i=!1,c=!1;this.methodInput=r.input.choice("Method",{value:l.c.UMAP,items:this.methods,onValueChanged:e=>{i&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=r.icons.settings(()=>{i=!i,i?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):r.empty(this.methodSettingsDiv)},"Modify methods parameters"),this.dbScanSettingsIcon=r.icons.settings(()=>{c=!c,c?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):r.empty(this.dbScanSettingsDiv)},"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=r.inputs([]);const u=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=r.input.choice("Encoding function",{value:u[0],items:u,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let h=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,h=!0),h||(r.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let d=!1;this.preprocessingFuncSettingsIcon=r.icons.settings(async()=>{d?r.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),d=!d},"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=r.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find(e=>!!this.columnFunctionsMap[e.name])??null,t=r.input.column("Column",{table:this.tableInput.value,value:e,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,r.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach(e=>this.colInputRoot.append(e)),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;if(!e)return;const t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach(e=>{Object.keys(this.supportedFunctions).forEach(t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))})}),this.regenerateColInput()};t(),e.columns.toList().some(e=>!!e.getTag(s.Tags.SemanticDetectionDuration))||e.meta.detectSemanticTypes().then(()=>{t()})}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=r.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(r.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){r.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=r.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),r.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach(e=>this.similarityMetricInputRoot.append(e)),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return r.empty(e),Object.keys(t).forEach(n=>{const i=t[n],o="string"===i.type?r.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?r.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):r.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,r.tooltip.bind(o.input??o.root,i.disableTooltip??"")):r.tooltip.bind(o.input??o.root,i.tooltip)}),e}async createPreprocessingFuncParamsDiv(e,t){if(r.empty(e),t.inputs.length<3)return r.div();const n=t.prepare(),i=await n.buildEditor(r.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find(e=>e.property.name===r.name);s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe(e=>{this.preprocessingFunctionSettings[r.name]=e}),e.append(s.root))}return e}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}var R=n(9713),$=n(6295);const O=e=>null==e;function k(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class H{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),f=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=m;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),m=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(h.set(r,i),s<p&&(p=s),a>g&&(g=a),e())}})}await Promise.all(l),n&&h.forEach((e,t)=>{h[t]=(e-p)/(g-p)}),i(h)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let m=0;const p=(a+1)/n;for(let e=0;e<o;e++)r[e]<p&&(l[m]=h[e],c[m]=d[e],u[m]=r[e],m++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)k(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)k(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,D=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class G{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new D.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,t),r=this.getPointOnDistance(S,x,w,C,n,t);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new D.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var q,j=n(3629);async function U(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,j.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(q||(q={}));const W={[q.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[q.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var z;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(z||(z={}));const Y={[z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[z.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},K={[z.HAMMING]:e=>Math.ceil(e/30),[z.EUCLIDEAN]:e=>Math.ceil(e/30),[z.MANHATTAN]:e=>Math.ceil(e/30),[z.TANIMOTO]:e=>Math.ceil(e/30),[z.SOKAL]:e=>Math.ceil(e/30),[z.COSINE]:e=>Math.ceil(e/30),[z.ASYMMETRIC]:e=>Math.ceil(e/30),[z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[z.Difference]:e=>1,[z.OneHot]:e=>Math.ceil(e/40),[z.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([z.HAMMING,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.MONOMER_CHEMICAL_DISTANCE,z.OneHot]),UINT32ARRAY:new Set([z.HAMMING,z.EUCLIDEAN,z.MANHATTAN,z.MONOMER_CHEMICAL_DISTANCE,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.TANIMOTO,z.COSINE,z.VECTOR_COSINE,z.SOKAL,z.ASYMMETRIC,z.OneHot,z.Difference]),INT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.OneHot,z.Difference,z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference,z.VECTOR_COSINE]),NUMBER:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference]),BITARRAY:new Set([z.TANIMOTO,z.COSINE,z.SOKAL,z.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield E.requestDevice(),M}}return M})}();if(!s)return null;const a=Object.values(z);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(q).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map((e,t)=>function(e,t=z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=K[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===z.NEEDLEMAN_WUNSCH||t===z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/f),T=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${J(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),L=new Uint32Array(f),_=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(A/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?A-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);L[e]=O,_[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),H=h.reduce((e,t)=>e+t.suppInfoSize,0),B=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let D=F;const G=15&F;0!==G&&(D+=16-G);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let U=0;new Uint32Array(j,U,f).set(L),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(_),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(N),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(P),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g.length).set(g),U+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const W=H*Uint32Array.BYTES_PER_ELEMENT;let Y=W;const X=15&W;0!==X&&(Y+=16-X),Y=Math.max(Y,16);const Q=s.createBuffer({label:"supp info buffer",size:Y,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,B);o+=B*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),Q.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function J(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${Y[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${W[i](e.length)}\n }\n \n `}var Q=n(1991),ee=n.n(Q);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,n,i,a,l,c,u,h,d,m,p,g,f,y,b){te++;const v=c/100;let w,C=!1;const A=o.shell.tv?.dataFrame===t?o.shell.tv:o.shell.getTableView(t.name);let S=null;if(h.useWebGPU)try{S=await X([i.entries],v,[u],q.MANHATTAN,[1],[i.options??{}])}catch(e){console.error(e)}S||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),S=await(new B).calc(i.entries,u,v,i.options));const x=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,a=s.BitSet.create(t.length);return e.distance.forEach((t,n)=>{a.set(e.i[n],!0),a.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:a}}(S,a),E=`sali_${l[0].substring(l[0].lastIndexOf("_"))}`;if(!t.columns.names().includes(E)){const i=function(e,t,n,i,o,r,a){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(a.get(i[e])>a.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return s.Column.fromList("double",t,l)}(n.length,E,x.saliVals,x.n1,x.n2,0,a);t.columns.add(i),e.setOptions({size:i.name})}const M=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(x.saliVals),T=.8/(M.max-M.min),I=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(t,x,n,a,d,m,M,T);I.lines.skipMultiLineCalculation=!0,I.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const L=new G(e,l[0],l[1],I.lines,F.none);let _=null;const N=r.button(`${I.linesDf.rowCount} cliffs`,()=>{if(!_?.dataFrame){_=(()=>{const e=f?f(I.linesDf,se).sort([oe],[!1]):I.linesDf.plot.grid().sort([oe],[!1]);return e.col(re)&&(e.col(re).visible=!1),t.temp[".cliffsDfGrid"]=_,e})();const e=ee()(A.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);b&&!e&&A.addViewer(_),A.dockManager.dock(_,"down",void 0,"Activity cliffs",y??.2)}});N.classList.add("scatter_plot_link","cliffs_grid");const P=r.input.toggle("Show only cliffs",{value:!1,onValueChanged:n=>{n?(e.dataFrame.setTag(ae,l[0]),t.filter.and(x.cliffsBitSet),ie.next(l[0])):(e.dataFrame.setTag(ae,""),t.filter.setAll(!0),ie.next(""))}});e.root.prepend(r.divH([N,P.root],"cliffs_div")),ie.subscribe(e=>{P.enabled=""===e||e===l[0]}),t.onRowsFiltering.subscribe(()=>{P.value&&t.filter.and(x.cliffsBitSet)});const $=o.events.onViewerClosed.subscribe(t=>{t.args.viewer===e&&(_&&A.dockManager.close(_.root),$.unsubscribe(),A.subs=A.subs.filter(e=>e!==$))});A.subs.push($),I.linesDf.onCurrentCellChanged.subscribe(()=>{for(let e=0;e<I.linesDf.rowCount;e++)I.lines.widths[e]=e===I.linesDf.currentRowIdx?3:1;L.linesToRender=I.lines;const i=I.linesDf.currentCol&&I.linesDf.currentCol.name===se[1]?I.lines.to:I.lines.from,s=-1!==I.linesDf.currentRowIdx?I.linesDf.currentRowIdx:null;if(e.dataFrame.currentRowIdx=s?i[s]:-1,null!==s){const i=I.linesDf.currentRowIdx;L.currentLineId=i;const{zoomLeft:c,zoomRight:u,zoomTop:h,zoomBottom:d}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<o?n:o)+s/2-h/2,p=(i>r?i:r)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(e.viewport.width,e.viewport.height,e.dataFrame.get(l[0],I.lines.from[i]),e.dataFrame.get(l[1],I.lines.from[i]),e.dataFrame.get(l[0],I.lines.to[i]),e.dataFrame.get(l[1],I.lines.to[i]));e.zoom(c,h,u,d),P.value?t.filter.and(x.cliffsBitSet):!0===P.enabled&&t.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,s,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:s,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout(()=>{o.shell.o=t.root},500)}(t,w,I.lines.from[s],I.lines.to[s],s,n,a,I.linesDf.get(oe,s),g);const i=e.dataFrame.getSortedOrder(A.grid.sortByColumns,A.grid.sortTypes);A.grid.scrollToCell(n.name,i.indexOf(e.dataFrame.currentRowIdx))},1e3)}}),I.linesDf.onSelectionChanged.subscribe(e=>{setTimeout(()=>(()=>{const e=s.BitSet.create(t.rowCount);for(let t=0;t<I.linesDf.rowCount;t++){const n=I.linesDf.selection.get(t);n&&(e.set(I.lines.from[t],!0),e.set(I.lines.to[t],!0)),I.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),L.linesToRender=I.lines})(),100)}),t.onSelectionChanged.subscribe(e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(!C&&_?.dataFrame?(e=>{e.selection.setAll(!1);for(let e=0;e<I.lines.colors.length;e++)I.lines.colors[e]="0,128,0";L.linesToRender=I.lines})(_.dataFrame):C=!1)}),L.lineClicked.subscribe(e=>{if(C=!0,L.currentLineId=e.id,-1!==e.id){const n=I.linesDf.selection.clone();setTimeout(()=>{if(e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),I.linesDf.selection.copyFrom(n)):(I.linesDf.currentRowIdx!==e.id&&(I.linesDf.currentRowIdx=e.id,t.currentRowIdx=I.lines.from[e.id]),I.linesDf.selection.copyFrom(n)),_?.dataFrame){const t=I.linesDf.getSortedOrder(_.sortByColumns,_.sortTypes);_.scrollToCell(se[0],t.indexOf(e.id))}},500)}}),L.lineHover.pipe((0,R.debounceTime)(500)).subscribe(e=>{-1!==e.id&&-1===t.mouseOverRowIdx&&r.tooltip.show(p({lineId:e.id,points:[I.lines.from[e.id],I.lines.to[e.id]],df:t,seqCol:n,activityCol:a}),e.x,e.y)}),e.addProperty("similarityLimit","double",v),w=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}()}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151),me=n(4025),pe=n(439);function ge(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getOriginal(o);(n(o)||i(o)).set(e,r,!1)}}const c=e.temp[me.j.notationProvider]??null,u=c?.monomerCanonicalizerFuncName;if(u)for(const e of o)e.setTag(pe.jz,u);return a}var fe,ye=n(4971);async function be(e){const t=(await(0,ye.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var ve=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ce extends P{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[_]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,Se,xe;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Me(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Te(e,t,i,l,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==l.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=s.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=g.embedColsNames??Ee(e);function x(n,o,l){let c=null,u=null;e.columns.names().includes(S[0])?(c=e.columns.byName(S[0]),u=e.columns.byName(S[1])):(c=e.columns.add(s.Column.float(S[0],e.rowCount)),u=e.columns.add(s.Column.float(S[1],e.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}))),g[a.YP]&&(A?.root&&r.setUpdateIndicator(A.root,!1),c.init(e=>l[0]?l[0][e]:void 0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function E(){e.columns.add(s.Column.float(S[0],e.rowCount)),e.columns.add(s.Column.float(S[1],e.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}),r.setUpdateIndicator(A.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await U(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:x))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await E();if(m&&M){const T=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),L=g.clusterColName??e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(L).init(e=>I[e].toString()),A&&(A.props.colorColumnName=L)}catch(_){o.shell.error("Clustering embeddings failed"),console.error(_)}finally{T.close()}}if(M){const N=e.columns.byName(S[0]),P=e.columns.byName(S[1]);if(N.init(e=>M[0][e]),P.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return r.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&r.setUpdateIndicator(A.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Se||(Se={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(xe||(xe={})),Object.prototype.toString;var Ie=n(6873),Le=n(4356),_e=n(6717);function Ne(e){var t;if((null===(t=o.shell.tv)||void 0===t?void 0:t.dataFrame)===e)return;const n=o.shell.tableView(e.name);n?o.shell.v=n:o.shell.addTableView(e)}var Pe=n(4870),Re=n(3856),$e=n(6882),Oe=n(7278),ke=n(5553),He=n(6642),Be=n(3599),Fe=n(673),De=n(8312);class Ge extends He.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,As.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,De.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ve=n(4139);const qe=ue.zS;function je(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class Ue extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=As.seqHelper}getRendererBack(e){const[t,n,i]=(0,He.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,ke.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,He.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(As.properties?As.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new $e.Jy(a,l,As.logger,d,()=>{const{font:e,fontWidth:t}=$e.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:qe}}),l.temp[".mm.cellRenderer.settingsChanged"],Fe.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class We extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator];let h=this.tableCol.meta.units;i=(0,$e.U0)(l,e,t,i,a);const[d,m]=c.split("#");h!==ue.Hi.CUSTOM||this.tableCol.temp[me.j.notationProvider]||(h=ue.Hi.SEPARATOR);const p=this.tableCol.temp[me.j.notationProvider]?.separatorSplitter??this.tableCol.temp[me.j.notationProvider]?.splitter??(0,Oe.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getOriginal(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getOriginal(e)).toArray(),v=this.tableCol.getTag(ue.gp.alphabet);Ye(e,t,n,i,o,y,b,v===ue.YI.RNA||v===ue.YI.DNA?Be.o.NUCLEOTIDE:Be.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new We(t,n)),o}}class ze extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ve.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){We.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Ye(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(pe.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(je(r).join("")),d=e.measureText(je(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=$e.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=$e.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Re.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Re.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ke(n,c,d,r,g,h,o))}else p=(0,Re.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ke(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(je([e]).join("")).width,u=l.measureText(je([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Ze,Xe=n(8070),Je=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Ze||(Ze={}));const Qe=new class{constructor(){this.regionTypes=[Ze.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Je.fH.Entropy,this.filterSource=Je.Fo.filterSource}};var et=n(7602),tt=n(250);const nt=Ze;var it,ot;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(it||(it={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ot||(ot={}));const rt=Qe;class st extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ot.skipEmptyPositions,rt.skipEmptyPositions,{category:it.DATA}),this.regionTypes=this.stringList(ot.regionTypes,rt.regionTypes,{category:it.DATA,choices:Object.values(nt).filter(e=>e!=nt.Unknown)}),this.chains=this.stringList(ot.chains,rt.chains,{category:it.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ot.fitWidth,rt.fitWidth,{category:it.LAYOUT}),this.positionWidth=this.float(ot.positionWidth,rt.positionWidth,{category:it.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ot.positionHeight,rt.positionHeight,{category:it.LAYOUT,choices:Object.keys(Je.fH)}),this.filterSource=this.string(ot.filterSource,rt.filterSource,{category:it.BEHAVIOR,choices:Object.values(Je.lT)}),this.viewSyncer=new et.g(As.logger)}static viewerCounter=-1;viewerId=++st.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case ot.regionTypes:case ot.chains:this.setData(this.regions)}switch(e.name){case ot.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ot.fitWidth:case ot.positionWidth:this.calcSize();break;case ot.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ot.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;As.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){As.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){As.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);r&&i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Je.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),As.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){As.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[tt.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[tt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(ot.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[tt.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Xe.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class at{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class lt{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class ct{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new lt(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new at);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new at);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ut(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=As.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,ye.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await be(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await be(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ht=n(4954);function dt(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function mt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=As.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=gt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(ft(i)),t.append(pt("Activity delta",Math.abs(n[0]-n[1]))),t.append(pt("Cliff",e.sali)),t}function pt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function gt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=As.monomerLib;return Ye(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function ft(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function yt(e,t){if(!e.col("seq_diff")){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n)}const n=e.plot.grid();return n.col(t[0]).visible=!1,n.col(t[1]).visible=!1,n}class bt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class vt extends bt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const wt={gapPenalty:1,matchScore:1,gapSymbol:pe.b9[pe.Hi.FASTA],localAlignment:!1};class Ct extends vt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Pe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Pe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ut(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new B).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...wt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new Oe.Mu(d,i.gapSymbol),seq2Splitted:new Oe.Mu(m,i.gapSymbol)}}(c,u),d=gt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(ft(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class At extends vt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Pe.Kd)(i,t.name,450,30),(0,Pe.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ut(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new H(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var St=n(5433),xt=n(3736),Et=n(4517);class Mt{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Tt={A:new D.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new D.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new D.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new D.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new D.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new D.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new D.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new D.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new D.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new D.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new D.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new D.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new D.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},It={RNA:{A:new D.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new D.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new D.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new D.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new D.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:Tt};async function Lt(e,t,n=0){if(!Object.keys(It).includes(t))return null;const i=await async function(e){const t=s.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new D.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!It[t])return null;const o=It[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var _t;!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(_t||(_t={}));class Nt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Pt extends Nt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Rt extends Pt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(_t.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(_t.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(_t.TYPE)&&-1!==e.indexOf(_t.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,_t.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<_t.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,_t.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,_t.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+_t.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=_t.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t extends Pt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ot{constructor(){}static getInstance(e){if(Ot.isMolfileV2K(e))return new Rt(e);if(Ot.isMolfileV3K(e))return new $t(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Rt.isValidMolfile(e)}static isMolfileV3K(e){return $t.isValidMolfile(e)}}var kt=n(6197),Ht=n(9124),Bt=n(3527);class Ft{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Ft.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Dt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Gt extends Ft{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Vt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class qt extends Ft{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class jt extends Ft{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Ut{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new jt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Ut(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Wt={[Be.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Be.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Be.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Be.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Be.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Be.o.CHEM]:{R:"#eeeeee"},[Be.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},zt=/.*\|\$.*R.*\$\|/,Yt=/\[R(\d+)\]/,Kt=/\[R(\d+)\]/g,Zt=/\[\*:(\d+)\]/g;function Xt(e,t){const n=Array.from(e.matchAll(Kt)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=Hn(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){As.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const Jt=/[\w()]+/,Qt=RegExp(String.raw`\(${Jt}(,${Jt})+\)`),en=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},tn=new Bt.Mi([255,255,255]),nn=new Bt.Mi([0,0,0]),on=.7*(0,j.wQ)(tn);class rn{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==pe._S||t===pe.b9[pe.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(zt.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return Xt(a,t)}let n=e;const i=Array.from(e.matchAll(Zt));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(Yt.test(n))return Xt(n,t)}catch(t){As.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Dt((0,Oe.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,Ht.fA)(e,t),o=(0,kt.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Be.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Be.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===pe._S||"*"==i?s=r.wem=new Gt(n):n===Be.o.NUCLEOTIDE&&"N"===i||n===Be.o.AA&&"X"===i||(Be.o.CHEM,0)||Qt.test(i)?s=r.wem=new Vt(n,i):r.lib||(s=r.wem=new qt(n,i,this.isEmpty)),s||(s=r.wem=Ut.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,kt.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?en(s.molfile):s.smiles?r.divV([en(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=pe._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Bt.Mi([...o.map(e=>e+1)]),a=(0,j.KE)(r,tn)/((0,j.wQ)(r)*(0,j.wQ)(tn)),l=i(n.backgroundcolor),c=new Bt.Mi([...l.map(e=>e+.01)]);let u;u=(0,j.KE)(c,tn)/((0,j.wQ)(c)*(0,j.wQ)(tn))<a?l:o;let h=new Bt.Mi(u);const d=(0,j.wQ)(h);return d>on&&(h=(0,j.dC)(nn,h,on/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,kt.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){As.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Wt[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var sn=n(5488),an={};an.styleTagTransform=C(),an.setAttributes=y(),an.insert=g().bind(null,"head"),an.domAPI=m(),an.insertStyleElement=v(),h()(sn.A,an),sn.A&&sn.A.locals&&sn.A.locals;class ln extends rn{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,kt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Ot.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Le.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new cn(e,`override: ${++ln.overrideCounter}, ${t}`,this)}}class cn extends rn{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var un=n(8604),hn=n(7433),dn=n.n(hn),mn=n(1913),pn=n.n(mn);class gn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(dn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});pn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class fn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=ye.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText(fn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new gn(i);fn._instance=new fn(r,e,t),fn._instance.refreshLists()}return fn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new ye.lH(n,i,o,r,s)});t.push(new ye.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}const yn="System:AppData/Bio/monomer-collections/";class bn{logger;_monomerLib=new ln({},"MAIN");_monomerSets=new ye.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await s.delay(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await fn.getInstance(this,As.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++bn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return bn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Le.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new ln(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Le.E)(un.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new ln(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===ye.ic);if(!t)throw new Error(`Provider '${ye.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new ln(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,ye.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async listMonomerCollections(){return(await o.dapi.files.list(yn)).filter(e=>"json"===e.extension||e.name.endsWith(".json")).map(e=>e.name)}async deleteMonomerCollection(e){e.endsWith(".json")||(e+=".json"),await o.dapi.files.exists(yn+e)&&await o.dapi.files.delete(yn+e)}async readMonomerCollection(e){e.endsWith(".json")||(e+=".json");const t=await o.dapi.files.readAsText(yn+e);return JSON.parse(t)}async addOrUpdateMonomerCollection(e,t,n,i){e.endsWith(".json")||(e+=".json");const r=JSON.stringify({description:n,tags:i,monomerSymbols:t,updatedBy:s.User.current().login,updatedOn:(new Date).toISOString()},null,2);await o.dapi.files.writeAsText(yn+e,r)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new bn(As.logger))()),e}}var vn=n(857),wn={};wn.styleTagTransform=C(),wn.setAttributes=y(),wn.insert=g().bind(null,"head"),wn.domAPI=m(),wn.insertStyleElement=v(),h()(vn.A,wn),vn.A&&vn.A.locals&&vn.A.locals;const Cn=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];function An(e,t,n){let i=t[e]??n[e];if(i&&i.length>0)return i;const r=Bn(e,Cn);if(r!==e){const e=o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles);if(i=t[e]??n[e],i&&i.length>0)return i}return[]}function Sn(e){const t=new Set;return e.filter(e=>!t.has(e.symbol)&&(t.add(e.symbol),!0))}function xn(e,t){const n=new Set;for(const i of e){const e=t[i.symbol];if(e&&e.length>0)for(const t of e){const e=t?.lib?.source;e&&n.add(e)}else i.source&&n.add(i.source)}return Array.from(n).join(", ")}var En;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(En||(En={}));const Mn={[En.MONOMER]:s.COLUMN_TYPE.STRING,[En.SYMBOL]:s.COLUMN_TYPE.STRING,[En.NAME]:s.COLUMN_TYPE.STRING,[En.R_GROUPS]:s.COLUMN_TYPE.STRING,[En.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[En.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[En.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[En.AUTHOR]:s.COLUMN_TYPE.STRING,[En.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[En.ID]:s.COLUMN_TYPE.INT,[En.META]:s.COLUMN_TYPE.STRING,[En.SOURCE]:s.COLUMN_TYPE.STRING};async function Tn(e){const t=await In(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>Fn(t.rows.get(n))))}async function In(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Mn))if(t.columns.addNew(e,n),e===En.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(En.SYMBOL).semType="Monomer",t.col(En.SYMBOL).setTag(Re.Mn.applyToBackground,"true"),t.col(En.SYMBOL).setTag(pe.qE.polymerTypeColumnName,En.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=kn(e[n].rgroups,e[n].smiles,e[n].molfile);o=_n(o),e[n].rgroups=$n(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?Pn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(En.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(En.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class Ln{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(En.NAME).width=100,this.tv.grid.col(En.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new On(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(En.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await bn.getInstance();await e.awaitLoaded(),this.instance=new Ln(e)}return this.instance}static async getNewInstance(){const e=await bn.getInstance();return await e.awaitLoaded(),new Ln(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewMonomersCollectionDialog(e){const t=(await this.monomerLibManamger.listMonomerCollections()).map(e=>e.toLowerCase()),n=r.input.string("Collection Name",{tooltipText:"Name of the monomer collection, should be unique",placeholder:"Enter collection name",nullable:!1}),i=r.input.string("Description",{tooltipText:"Description of the monomer collection",placeholder:"Enter collection description",nullable:!0}),s=r.dialog("Create New Monomer Collection").add(n).add(i).addButton("Add",async()=>{if(!n.value||!n.value.trim())return void o.shell.warning("Collection name cannot be empty");const a=async e=>{await this.monomerLibManamger.addOrUpdateMonomerCollection(n.value,e,i.value??void 0),o.shell.info(`Collection ${n.value} saved successfully`)};if(t.includes(n.value.toLowerCase())||t.includes(n.value.toLowerCase()+".json")){const t=r.dialog("Collection already exists").add(r.divText(`A collection with the name ${n.value} already exists. Do you want to merge or overwrite it?`));t.addButton("Merge",async()=>{const i=await this.monomerLibManamger.readMonomerCollection(n.value),r=Array.from(new Set([...i.monomerSymbols??[],...e]));try{await a(r)}catch(e){o.shell.error("Error merging monomer collection"),console.error(e)}t.close()}),t.addButton("Overwrite",async()=>{try{await a(e)}catch(e){o.shell.error("Error overwriting monomer collection"),console.error(e)}t.close()}),t.show()}else try{await a(e)}catch(e){o.shell.error("Error creating monomer collection"),console.error(e)}s.close()}).show()}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex,n=e.menu;if(n.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),n.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0){const e=n.group("Selected Monomers");e.item("Remove",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Fn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.item("Create Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Fn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}),e.item("Create Collection",async()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>this.tv.dataFrame.col(En.SYMBOL).get(e)).filter(e=>!!e&&e.trim().length>0);if(0===e.length)return o.shell.warning("No valid monomer symbols found in selection");this.createNewMonomersCollectionDialog(e)})}else n.item("Remove Monomer",async()=>{const e=await Fn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===Ln.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:Ln.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Fn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Fn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)},"Delete");r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=Ln.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Fn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,ye.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await In(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Fn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const Nn=["alternateId","capGroupName","capGroupSMILES","label"];function Pn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Rn(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function $n(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(Nn,e),n=Pn(t,"capGroupSMILES"),i=Pn(t,"alternateId"),o=Pn(t,"capGroupName"),r=Pn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class On{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Dn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=kn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Lt(Bn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Mt(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Mt(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=$n(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&Lt(Bn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=kn(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(En.POLYMER_TYPE)?.toList()??[],s=n?.col(En.SYMBOL)?.toList()??[],a=n?.col(En.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await Fn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await Fn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=kn([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=Hn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function kn(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=_n(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function Hn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function Bn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=Pn(e,"capGroupName"),r=Pn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function Fn(e){let t;try{t=JSON.parse(e.get(En.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(En.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=Hn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(En.NATURAL_ANALOG);const a=e.get(En.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(En.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=Pn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?Rn(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?Rn(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?Rn(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&Rn(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=Pn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&Rn(e,"capGroupSMILES",`${Pn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await Lt(Bn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(En.SYMBOL),name:e.get(En.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(En.MONOMER_TYPE),naturalAnalog:r,id:e.get(En.ID),rgroups:l,meta:t,author:e.get(En.AUTHOR),createDate:e.get(En.CREATE_DATE)}}class Dn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}function Gn(e){const t={Symbol:e.symbol,Name:e.name,"Polymer Type":e.polymerType,"Monomer Type":e.monomerType};if(e.author&&(t.Author=e.author),e.naturalAnalog&&(t["Natural Analog"]=e.naturalAnalog),e.lib?.source){let n=e.lib.source;n.endsWith(".json")&&(n=n.substring(0,n.length-5)),t.Library=n}e.molfile?t.Structure=o.chem.drawMolecule(e.molfile,150,150):e.smiles&&(t.Structure=o.chem.drawMolecule(e.smiles,150,150));const n=e.rgroups;if(n&&n.length>0)for(const e of n)t[e.label??"?"]=e.alternateId??"";return r.tableFromMap(t)}function Vn(e){const t=function(e){try{return Bn(kn(e.rgroups,e.smiles,e.molfile),e.rgroups)}catch{}return null}(e);if(!t)return r.divText("No molecular structure available");const n=s.SemanticValue.fromValueType(t,s.SEMTYPE.MOLECULE);return r.panels.infoPanel(n).root}var qn=n(3890),jn=n(1687);function Un(e){return e.split(/,(?![^(]*\))/).map(e=>('"'===(e=e.trim()).slice(0,1)&&'"'===e.slice(-1)&&(e=e.slice(1,-1)),"'"===e.slice(0,1)&&"'"===e.slice(-1)&&(e=e.slice(1,-1)),e.trim())).filter(e=>!!e)}class Wn{constructor(e,t,n,i){this.currentMenu=null,this.menuItems=[],this.highlightedIndex=-1,this.monomerLib=e,this.polymerType=t,this.helmType=(0,Oe.MD)(t),this.allSymbols=e.getMonomerSymbolsByType(t),this.libHelper=i,this.selectedMonomers=n?[...n]:[],this.tagsHost=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px",marginTop:"4px",maxHeight:"150px",overflowY:"auto"}}),this.countLabel=r.divText("",{style:{fontSize:"11px",color:"var(--grey-4)",marginTop:"4px"}});const o=r.input.string("Search",{value:""});this.inputEl=o.input,this.inputEl.setAttribute("autocomplete","off"),this.inputEl.placeholder="Type to search monomers...",this.setupInputListeners();const s=this.createLibrarySection(),a=this.createCollectionSection(),l=r.button("Clear all",()=>{this.selectedMonomers.length=0,this.renderTags()});l.style.fontSize="11px",l.style.marginTop="4px",this.renderTags(),this.root=r.div([o.root,s,a,r.divH([this.countLabel,l],{style:{justifyContent:"space-between",alignItems:"center"}}),this.tagsHost],{style:{minWidth:"300px"}})}getSelectedMonomers(){return[...this.selectedMonomers]}setSelectedMonomers(e){this.selectedMonomers.length=0,this.selectedMonomers.push(...e),this.renderTags()}setPolymerType(e){this.polymerType=e,this.helmType=(0,Oe.MD)(e),this.allSymbols=this.monomerLib.getMonomerSymbolsByType(e)}focus(){this.inputEl.focus()}updateCountLabel(){this.countLabel.textContent=this.selectedMonomers.length>0?`${this.selectedMonomers.length} monomer(s) selected`:""}renderTags(){this.tagsHost.innerHTML="";for(const e of this.selectedMonomers){const t=r.iconFA("times",()=>{const t=this.selectedMonomers.indexOf(e);t>=0&&(this.selectedMonomers.splice(t,1),this.renderTags(),this.updateCountLabel())});t.style.marginLeft="4px",t.style.cursor="pointer";const n=r.div([r.span([e]),t],{style:{display:"inline-flex",alignItems:"center",padding:"2px 6px",borderRadius:"4px",backgroundColor:"var(--grey-2)",border:"1px solid var(--grey-3)",fontSize:"12px",cursor:"default"}});n.addEventListener("mouseenter",()=>{const t=this.monomerLib.getTooltip(this.helmType,e);r.tooltip.show(t,n.getBoundingClientRect().left,n.getBoundingClientRect().bottom+16)}),n.addEventListener("mouseleave",()=>{r.tooltip.hide()}),this.tagsHost.appendChild(n)}this.updateCountLabel()}addMonomer(e){this.selectedMonomers.includes(e)||(this.selectedMonomers.push(e),this.renderTags()),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}addMonomers(e){let t=!1;for(const n of e)this.selectedMonomers.includes(n)||(this.selectedMonomers.push(n),t=!0);t&&this.renderTags()}hideMenu(){this.currentMenu&&(this.currentMenu.hide(),this.currentMenu=null),this.menuItems=[],this.highlightedIndex=-1}getSuggestions(e){const t=e.toLowerCase(),n=[];for(const e of this.allSymbols){if(this.selectedMonomers.includes(e))continue;const i=this.monomerLib.getMonomer(this.polymerType,e),o=e.toLowerCase(),r=i?.name?.toLowerCase()??"";o.startsWith(t)?n.push({symbol:e,monomer:i,rank:0}):o.includes(t)?n.push({symbol:e,monomer:i,rank:1}):r.includes(t)&&n.push({symbol:e,monomer:i,rank:2})}return n.sort((e,t)=>e.rank-t.rank||e.symbol.localeCompare(t.symbol)),n.slice(0,20)}showSuggestions(){this.hideMenu();const e=this.inputEl.value.trim();if(!e)return;const t=this.getSuggestions(e);if(0===t.length)return;this.currentMenu=s.Menu.popup();const n=t.reduce((e,t)=>{const n=t.monomer?.name?`${t.symbol} - ${t.monomer.name}`:t.symbol;return e.length<n.length?n:e},"");this.currentMenu.item(n,()=>{});const i=new MouseEvent("mousemove",{clientX:this.inputEl.getBoundingClientRect().left,clientY:this.inputEl.getBoundingClientRect().bottom});this.currentMenu.show({causedBy:i,y:this.inputEl.offsetHeight+this.inputEl.offsetTop,x:this.inputEl.offsetLeft}),setTimeout(()=>{this.currentMenu?.clear();for(const e of t){const t=e.monomer?.name?`${e.symbol} - ${e.monomer.name}`:e.symbol;this.currentMenu?.item(t,()=>{this.addMonomer(e.symbol)})}const e=document.querySelector(".d4-menu-popup:last-of-type");e&&(this.menuItems=Array.from(e.querySelectorAll(".d4-menu-item"))),this.highlightedIndex=-1},0)}updateHighlight(e){0!==this.menuItems.length&&(this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&this.menuItems[this.highlightedIndex].classList.remove("d4-menu-item-hover"),this.highlightedIndex=e,this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&(this.menuItems[this.highlightedIndex].classList.add("d4-menu-item-hover"),this.menuItems[this.highlightedIndex].scrollIntoView({block:"nearest"})))}setupInputListeners(){this.inputEl.addEventListener("input",()=>{this.showSuggestions()}),this.inputEl.addEventListener("paste",e=>{const t=e.clipboardData?.getData("text");if(!t)return;const n=t.split(/[\n\r]+/).map(e=>e.trim()).filter(e=>e.length>0),i=[];for(const e of n){const t=Un(e);1===t.length&&e.includes(" ")&&!e.includes(",")?i.push(...e.split(/\s+/).map(e=>e.trim()).filter(e=>e.length>0)):i.push(...t)}if(!(i.length<=1)){e.preventDefault();for(const e of i)this.selectedMonomers.includes(e)||this.selectedMonomers.push(e);this.renderTags(),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}}),this.inputEl.addEventListener("keydown",e=>{if("ArrowDown"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex+1)%this.menuItems.length;this.updateHighlight(e)}}else if("ArrowUp"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex-1+this.menuItems.length)%this.menuItems.length;this.updateHighlight(e)}}else if("Enter"===e.key)if(e.preventDefault(),e.stopPropagation(),this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length)this.menuItems[this.highlightedIndex].click();else{const e=this.inputEl.value.trim();e&&this.addMonomer(e)}else"Escape"===e.key&&this.hideMenu()})}createLibrarySection(){const e=r.div([],{style:{marginTop:"8px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from library",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.getAvaliableLibraryNames().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=await t.readSingleLibraryByName(e);if(n){const t=n.getMonomerSymbolsByType(this.polymerType),o=this.selectedMonomers.length;this.addMonomers(t);const r=this.selectedMonomers.length-o;i.textContent=`Added ${r} monomer(s) from "${e}"`}else i.textContent=`Library "${e}" not found`}catch(e){i.textContent="Error loading library"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}createCollectionSection(){const e=r.div([],{style:{marginTop:"4px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from collection",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.listMonomerCollections().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=(await t.readMonomerCollection(e)).monomerSymbols??[],o=this.selectedMonomers.length;this.addMonomers(n);const r=this.selectedMonomers.length-o,s=e.replace(/\.json$/,"");i.textContent=`Added ${r} monomer(s) from "${s}"`}catch(e){i.textContent="Error loading collection"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}}class zn extends s.ObjectHandler{get type(){return"MonomerCollection"}get name(){return"Monomer Collection"}isApplicable(e){return Array.isArray(e)?e.length>0&&e.every(e=>this.isSingleCollection(e)):this.isSingleCollection(e)}isSingleCollection(e){return null!=e&&"object"==typeof e&&"name"in e&&"displayName"in e&&"data"in e&&void 0!==e.data?.monomerSymbols}getCaption(e){return Array.isArray(e)?`${e.length} collections`:e.displayName}renderProperties(e,t=null){return Array.isArray(e)?this.renderMultiProperties(e):this.renderSingleProperties(e)}renderSingleProperties(e){const t=r.accordion("Monomer Collection"),n=s.User.current().login,i=e.data.updatedBy===n;return t.addPane("Details",()=>{const t={Name:e.displayName};if(e.data.description&&(t.Description=e.data.description),e.data.tags&&e.data.tags.length>0&&(t.Tags=e.data.tags.join(", ")),t.Monomers=`${e.data.monomerSymbols.length}`,e.data.updatedBy&&(t["Updated by"]=e.data.updatedBy),e.data.updatedOn)try{t["Updated on"]=new Date(e.data.updatedOn).toLocaleString()}catch{}return r.tableFromMap(t)},!0),t.addPane("Monomers",()=>{const t=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px"}}),n=this.getMonomerLib();for(const i of e.data.monomerSymbols){const e=r.div([i],{style:{display:"inline-block",padding:"2px 8px",borderRadius:"4px",background:"var(--grey-1)",border:"1px solid var(--grey-2)",fontSize:"11px",color:"var(--grey-5)",cursor:"pointer"}});e.addEventListener("mouseenter",()=>{if(n){const t=zn.getMonomerTooltipSafe(n,i);if(t){const n=e.getBoundingClientRect();r.tooltip.show(t,n.left,n.bottom+4)}}}),e.addEventListener("mouseleave",()=>r.tooltip.hide()),e.addEventListener("click",()=>{o.shell.o=s.SemanticValue.fromValueType(i,Ve.uF.MONOMER)}),t.appendChild(e)}return t},!0),t.addPane("Actions",()=>{const t=[],n=r.button("Edit",async()=>{i&&await this.editCollection(e)},i?"Edit this collection":"Only the author can edit");i||zn.disableButton(n),t.push(n);const o=r.button("Delete",async()=>{i&&await this.deleteCollection(e)},i?"Delete this collection":"Only the author can delete");return i||zn.disableButton(o),t.push(o),t.push(r.button("Duplicate",async()=>{await this.duplicateCollection(e)},"Create a copy of this collection")),r.divH(t)},!0),t.root}renderMultiProperties(e){const t=r.accordion("Monomer Collections"),n=s.User.current().login,i=e.every(e=>e.data.updatedBy===n);return t.addPane("Selection",()=>{const t=r.list(e.map(e=>e.displayName));return r.divV([r.divText(`${e.length} collections selected`),t])},!0),t.addPane("Actions",()=>{const t=[];t.push(r.button("Merge",async()=>{await this.mergeCollections(e)},"Merge selected collections into one"));const n=r.button("Delete All",async()=>{i&&await this.deleteMultipleCollections(e)},i?"Delete all selected collections":"Only the author can delete (you must be author of all)");return i||zn.disableButton(n),t.push(n),r.divH(t)},!0),t.root}async editCollection(e){const t=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(t&&t._mcView)t._mcView.editCollectionPublic(e.name,e.data);else{const t=await bn.getInstance();await t.awaitLoaded();const n=t.getMonomerLib();this.showEditDialog(e,t,n)}}showEditDialog(e,t,n){const i=r.input.string("Name",{value:e.displayName,nullable:!1}),s=r.input.string("Description",{value:e.data.description??"",nullable:!0}),a=r.input.string("Tags",{value:(e.data.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(n,l.value,[...e.data.monomerSymbols??[]],t);l.onChanged.subscribe(()=>c.setPolymerType(l.value)),r.dialog({title:`Edit Collection: ${e.displayName}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const n=i.value?.trim();if(!n)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=this.parseTags(a.value);try{n!==e.displayName&&await t.deleteMonomerCollection(e.name),await t.addOrUpdateMonomerCollection(n,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${n}" saved successfully`),await this.refreshView()}catch(e){o.shell.error("Error saving collection")}}).show({resizable:!0}).root.style.width="550px",c.focus()}async deleteCollection(e){r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete "${e.displayName}"?`)).onOK(async()=>{try{const t=await bn.getInstance();await t.deleteMonomerCollection(e.name),o.shell.info(`Collection "${e.displayName}" deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collection")}}).show()}async duplicateCollection(e){const t=r.input.string("New Name",{value:`${e.displayName} (copy)`,nullable:!1});r.dialog({title:"Duplicate Collection"}).add(t).onOK(async()=>{const n=t.value?.trim();if(n)try{const t=await bn.getInstance();await t.addOrUpdateMonomerCollection(n,[...e.data.monomerSymbols],e.data.description,e.data.tags?[...e.data.tags]:void 0),o.shell.info(`Collection "${n}" created`),await this.refreshView()}catch(e){o.shell.error("Error duplicating collection")}else o.shell.warning("Name is required")}).show()}async mergeCollections(e){const t=r.input.string("Merged Name",{value:"Merged Collection",nullable:!1}),n=r.input.string("Description",{nullable:!0,placeholder:"Optional description"});r.dialog({title:`Merge ${e.length} Collections`}).add(r.divV([r.divText(`Merging: ${e.map(e=>e.displayName).join(", ")}`),t,n])).onOK(async()=>{const i=t.value?.trim();if(i)try{const t=[...new Set(e.flatMap(e=>e.data.monomerSymbols))],r=[...new Set(e.flatMap(e=>e.data.tags??[]))],s=await bn.getInstance();await s.addOrUpdateMonomerCollection(i,t,n.value??void 0,r.length>0?r:void 0),o.shell.info(`Merged collection "${i}" created with ${t.length} monomers`),await this.refreshView()}catch(e){o.shell.error("Error merging collections")}else o.shell.warning("Name is required")}).show()}async deleteMultipleCollections(e){r.dialog({title:"Delete Collections"}).add(r.divText(`Are you sure you want to delete ${e.length} collections?\n${e.map(e=>e.displayName).join(", ")}`)).onOK(async()=>{try{const t=await bn.getInstance();for(const n of e)await t.deleteMonomerCollection(n.name);o.shell.info(`${e.length} collections deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collections")}}).show()}async refreshView(){const e=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(e&&e._mcView){const t=e._mcView;await t.refresh()}}parseTags(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}getMonomerLib(){return As.monomerLib??null}static getMonomerTooltipSafe(e,t){const n=[Be.o.AA,Be.o.NUCLEOTIDE,Be.o.CHEM,Be.o.BLOB];for(const i of n)try{if(e.getWebEditorMonomer(i,t))return e.getTooltip(i,t)}catch{}return null}static disableButton(e){e.style.opacity="0.4",e.style.cursor="default"}static buildContextMenu(e,t,n){const i=s.User.current().login,o=t.data.updatedBy===i;e.item("Edit",()=>{o&&n.editCollection(t)},null,{isEnabled:()=>o?null:"Only the author can edit"}),e.item("Delete",()=>{o&&n.deleteCollection(t)},null,{isEnabled:()=>o?null:"Only the author can delete"}),e.item("Duplicate",()=>n.duplicateCollection(t))}static buildMultiContextMenu(e,t,n){const i=s.User.current().login,o=t.every(e=>e.data.updatedBy===i);e.item("Merge",()=>n.mergeCollections(t)),e.item("Delete All",()=>{o&&n.deleteMultipleCollections(t)},null,{isEnabled:()=>o?null:"Only the author can delete (you must be author of all)"})}}var Yn=n(1757),Kn=n.n(Yn);class Zn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Xn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Zn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Jn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Jn._instance||(Jn._instance=new Jn,await Jn._instance.refresh(),(await bn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Jn._instance.refresh())),Jn._instance.refresh(),Jn._instance}async refresh(){this.settings=await(0,Le.u)();const e=await bn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Xn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Le.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Le.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Qn=n(3017),ei={};async function ti(){await si.showDialog()}async function ni(e=!0){return await ai.showView(e)}ei.styleTagTransform=C(),ei.setAttributes=y(),ei.insert=g().bind(null,"head"),ei.domAPI=m(),ei.insertStyleElement=v(),h()(Qn.A,ei),Qn.A&&Qn.A.locals&&Qn.A.locals;class ii{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==ii.instancePromise&&(ii.instancePromise=(async()=>{const e=new ii,t=await(0,ye.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),ii.instancePromise}static async reloadWidget(){const e=await ii.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,ye.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await oi.createControlsForm();return Kn()(e).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),setTimeout(()=>{e&&Kn()(e)&&Kn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class oi{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){As.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Le.u)(),t=await(0,ye.pj)();return new oi(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Kn()(t).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),t}async updateControlsForm(){const e=await this._createControlsForm();Kn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;As.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{ri(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e),"Delete"),a=r.icons.edit(async()=>{o.shell.v=await(await Ln.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),As.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await ri(!1,e);const n=await(0,ye.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function ri(e,t){const n=await(0,Le.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Le.E)(n);const i=await(0,ye.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class si{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){si._instance||(si._instance=new si,si._instance.closeDialogSubject$.subscribe(()=>{si._instance.dialog=void 0})),si._instance.dialog||(si._instance.dialog=await si._instance.getDialog()),si._instance.dialog.show()}async getDialog(){const e=(await ii.getInstance()).widget,t=await(0,ye.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Kn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class ai{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await ii.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=ai.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=ai._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return ai._instance||(ai._instance=new ai),ai._instance._duplicateManager||(ai._instance._duplicateManager=await Jn.getInstance()),ai._instance.libManager||(ai._instance.libManager=await bn.getInstance()),e&&ai._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===ai._instance._view.id)?(o.shell.v=ai._instance._view,await ai._instance._duplicateManager.refresh(),ai._instance._view):(ai.closeExistingViews(),ai._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===ai.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await bn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Le.u)();i.exclude=l,await(0,Le.E)(i),await this.libManager.loadMonomerLib(!0),await ii.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var li,ci=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ui{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>ci(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>ci(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>ci(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>ci(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,ui.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return ci(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield s.delay(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep===this.stepNumber)return this._restartBtn.disabled=!1,void(this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn));if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))})}_startScript(){return ci(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return ci(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return ci(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return ci(this,void 0,void 0,function*(){this._restartBtn.disabled=!0,o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ui.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return ci(this,void 0,void 0,function*(){var e;(null===(e=o.shell.v)||void 0===e?void 0:e.name)===this.name&&o.shell.v.close(),this._initRoot(),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ui.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(li||(li={}));var hi=n(966),di=n(608),mi=n(1619),pi=n(8152);class gi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${As.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case tt.n5.fixWidth:case tt.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var yi=n(6869);const bi="-";class vi extends Ge{constructor(e,t){super(e,t)}static _canonLoadingKey=pe.sc+".loading";getCanonicalizer(e){const t=e.temp[pe.sc]??null;if(t)return t;if(e.temp[vi._canonLoadingKey])return null;const n=e.getTag(pe.jz);if(!n)return null;const i=n.includes(":")?n.split(":"):[void 0,n],o=s.Func.find({name:i[1],package:i[0]});return 0===o.length||(e.temp[vi._canonLoadingKey]=!0,o[0].apply({}).then(t=>{e.temp[pe.sc]=t,e.temp[vi._canonLoadingKey]=!1,this.gridCol?.grid?.invalidate&&this.gridCol.grid.invalidate()}).catch(()=>{e.temp[vi._canonLoadingKey]=!1})),null}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";const a=e.measureText("M"),l=a.actualBoundingBoxAscent+a.actualBoundingBoxDescent+8;let c=r.cell.value;c&&c!==pe._S||(c=bi);const u=c.split(pe.ot).map(e=>e&&e!==pe._S?e.trim():bi),h=u.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/u.length)))),d=h.map(t=>e.measureText(t).width+4),m=d.reduce((e,t)=>e+t,0);let p=t+(i-m)/2+2;const g=this.tableCol.getTag(pe.gp.alphabet),f=g===ue.YI.RNA||g===ue.YI.DNA?yi.o.NUCLEOTIDE:yi.o.AA;for(let a=0;a<h.length;a++){const c=u[a],m=this.getHelmType(r,f);let g=$e.S$,y="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,c);g=e?.textcolor??g,y=e?.backgroundcolor??y}else g=this.monomerLib.getMonomerTextColor(m,c);if(s)if(e.fillStyle=y,i<30||o<30)e.fillRect(t+a*i/h.length,n,i/h.length,o);else{const t=2;e.roundRect(p-2,n+o/2-l/2,d[a],l,t),e.fill()}e.fillStyle=g,e.fillText(h[a],p,n+o/2,i),p+=d[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,He.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(pe.gp.alphabet),a=e.cell.value,l=this.getCanonicalizer(i),c=l&&a?l.canonicalize(a):a,u=e.grid.canvas.getBoundingClientRect(),h=e.bounds.right+u.left-4,d=e.bounds.bottom+u.top-4;if(!a||a==pe._S||a==bi||null!=l&&l.isGap(a))return r.tooltip.show(r.divText("gap"),h,d),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),h,d),!0;const m=s===ue.YI.RNA||s===ue.YI.DNA?yi.o.NUCLEOTIDE:yi.o.AA,p=c.split(pe.ot).map(t=>{if(!t||t===pe._S||t===bi)return r.divText("gap");const n=this.getHelmType(e,m);return this.monomerLib.getTooltip(n,t)}),g=r.divH(p,{style:{alignItems:"top",flexWrap:"wrap",gap:"4px"}}),f=Array.from(g.querySelectorAll("canvas"));if(f.length>2){const e=Math.floor(550/f.length);f.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(g,h,d),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,He.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(pe.qE.polymerTypeColumnName)){const t=o.getTag(pe.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,Oe.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new vi(t,n)),o}}class wi extends s.GridCellRenderer{get name(){return Ve.uF.MONOMER}get cellType(){return Ve.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){vi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){vi.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class Ci{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class Ai extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class Si extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new Ci(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ve.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var xi=n(6307),Ei=n(5999),Mi={};Mi.styleTagTransform=C(),Mi.setAttributes=y(),Mi.insert=g().bind(null,"head"),Mi.domAPI=m(),Mi.insertStyleElement=v(),h()(Ei.A,Mi),Ei.A&&Ei.A.locals&&Ei.A.locals;class Ti extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=As.properties.tooltipWebLogo,n=this.seqCol.getTag(Je.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}var Ii=n(4951);function Li(e,t,n,i){const o=As.seqHelper.getSeqHandler(e);let r=null,a=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(a=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==a&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<a)throw new Error(`End position ${a} exceeds positions length`);const l=i||`${e.name}: (${t??""}-${n??""})`,c=function(e,t,n,i,o){if(!n||!i||!e.dataFrame)return null;const r=e.getTag(ue.gp.annotations);if(!r)return null;let a;try{a=JSON.parse(r)}catch{return null}const l=a.find(e=>e.category===Et.eI.Structure&&e.start===n&&e.end===i);if(!l)return null;const c=(0,xt.VT)(e.name);let u=null;try{u=e.dataFrame.columns.byName(c)}catch{return null}if(!u)return null;const h=(0,xt.wi)(u);if(!h.some(e=>e?.some(e=>e.annotationId===l.id&&null!=e.endPositionIndex)))return null;const d=e.dataFrame,m=s.Column.fromType(s.COLUMN_TYPE.STRING,o,d.rowCount);for(let e=0;e<d.rowCount;e++){const n=h[e],i=n?.find(e=>e.annotationId===l.id&&null!=e.endPositionIndex);if(i){const n=t.getSplitted(e),o=[];for(let e=i.positionIndex;e<=i.endPositionIndex;e++)e<n.length&&o.push(n.getOriginal(e));m.set(e,o.join(t.separator||""))}else m.set(e,"")}return m}(e,o,t,n,l);return c||o.getRegion(r,a,l)}const _i={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Ni{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??_i;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${As.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Pi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value;let t=null;const n=e?e.getTag(ue.gp.annotations):null;if(n)try{const e=JSON.parse(n).filter(e=>"structure"===e.category&&e.start&&e.end);e.length>0&&(t=e.map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end})))}catch{}if(!t){const n=e?e.getTag(ue.gp.regions):null;t=n?JSON.parse(n):null}const i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=t){this.inputs.region.root.style.removeProperty("display");for(const e of t){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{As.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{As.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var Ri=n(8754);async function $i(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=ge(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):pe._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=ge(e,n).columns.toList());const i=(await(0,ye.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):pe._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==pe._S&&t!==p?l[e]+=y[t]:c===pe._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null==u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Oi=n(294),ki=n(330);const Hi=OCL;var Bi=n(2582);class Fi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var Di=n(6956);class Gi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===Di.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=Ot.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const v=new Map;v.set(p+1,e+1);let w=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),v.set(e+1,w),w++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=v.get(t),o=v.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Vi{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class qi extends Vi{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class ji{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ui extends ji{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Wi extends Fi{constructor(e,t){super(t);const n=Ot.getInstance(e);this.atoms=new qi(n),this.bonds=new Ui(n),this.rGroups=new Gi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class zi extends Vi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Yi extends ji{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Ki extends Fi{constructor(e,t){super(t);const n=Ot.getInstance(e);this.atoms=new zi(n),this.bonds=new Yi(n),this.rGroups=new Gi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Zi{static getInstance(e,t){if(Ot.isMolfileV2K(e))return new Wi(e,t);if(Ot.isMolfileV3K(e))return new Ki(e,t);throw new Error("Unsupported molfile version")}}class Xi{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Ot.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Zi.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Xi.molfileV2KToV3KCache.has(e))return Xi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Xi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ji{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Bi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===pe.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Xi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Oi.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Be.o.NUCLEOTIDE:Be.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Qi{constructor(e){this.molfileHandler=Ot.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class eo{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Hi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,ve.AP)(e);return As.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,ki.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Oi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,ve.AP)(e);As.logger.error(t,void 0,n),o=Oi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Qi(o),s=new Ji(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Oi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Oi.vF(a.molfile,l)}}var to=n(2738);class no{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[me.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}runInnerDetector(){if(!this._column.temp.seqHandlerDetectorRun){this._column.temp.seqHandlerDetectorRun=!0;const e=s.Func.find({name:"detectMacromolecule",meta:{role:"semTypeDetector"}})[0];e&&e.applySync({col:this._column})}}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;let n=this._column.meta.units;if(!n&&(this.runInnerDetector(),n=this._column.meta.units,!n))throw new Error("Units are not specified in column");if(this._units=n,this._notation=this.getNotation(),[ue.Hi.BILN,ue.Hi.CUSTOM,ue.Hi.SEPARATOR].includes(this._notation)&&!this.column.getTag(ue.gp.separator)&&(this.runInnerDetector(),!this.column.getTag(ue.gp.separator)))throw new Error(`Separator tag '${ue.gp.separator}' is not set for notation '${this._notation}'.`);(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[me.j.notationProvider]??null);const i=this.isFasta()?pe.b9[ue.Hi.FASTA]:this.isSeparator()?pe.b9[ue.Hi.SEPARATOR]:this.isHelm()?pe.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??pe.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[me.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.BILN].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength||e.column.categories.slice(0,5).filter(e=>!!e).every(e=>e.length>100)?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,Oe.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new to.aD(e.name,e.alphabet,.9));t=(0,Oe.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?Be.o.NUCLEOTIDE:Be.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===pe.b9[ue.Hi.FASTA]?pe._S:i??pe._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(pe._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===pe.b9[ue.Hi.FASTA]?pe._S:o??pe._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new me.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!no.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:Oe.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?pe.b9[ue.Hi.FASTA]:pe.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===pe.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=pe.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new Oe.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return io(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return oo(n,t,e)};break}case ue.Hi.BILN:i=function(e){return ro(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[me.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[me.j.seqHandler]=new no(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return io(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return oo(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:ro(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new Oe.Mu(n.filter(e=>!!e),pe.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function io(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function oo(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===pe._S?r=pe.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===pe._S?s=pe.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function ro(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class so{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return no.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Ht.b2)();return new eo(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Oi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Oi.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Oi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Oi.vF(e,o.monomers)}catch(e){const[t,n]=(0,ve.AP)(e);return As.logger.error(t,void 0,n),Oi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,ki.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,no.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),no.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,no.setTags(e)}}async function ao(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await xs.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[me.j.notationProvider]&&(i.temp[me.j.notationProvider]=e.cell.column.temp[me.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await xs.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){As.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const lo="#333333",co="rgba(60, 177, 115, 0.1)",uo="rgba(240, 240, 240, 0.5)",ho="rgba(100, 100, 100, 0.3)";class mo{constructor(e=fo.DEFAULT_TRACK_HEIGHT,t=fo.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class po extends mo{constructor(e=new Map,t=fo.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,fo.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Be.o.NUCLEOTIDE;break;default:t=Be.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,xi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=co,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=uo,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=ho,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class go extends mo{constructor(e,t=fo.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,fo.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=co,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=uo,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=ho,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=lo,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const fo={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35,ANNOTATION_TRACK_HEIGHT:20},yo={BASE:fo.DOTTED_CELL_HEIGHT+fo.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+fo.TITLE_HEIGHT+fo.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+fo.DEFAULT_TRACK_HEIGHT+fo.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+fo.DEFAULT_TRACK_HEIGHT+fo.TRACK_GAP}};class bo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||yo.BASE,sliderHeight:e.sliderHeight||fo.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0,dragMode:"none",dragStartWindowPosition:1,dragOccurred:!1},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation"),i=this.getTrack("annotations");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(fo.DEFAULT_TRACK_HEIGHT)}),e<yo.WITH_TITLE())return;let o=0;i&&(i.setVisible(!0),i.setHeight(fo.ANNOTATION_TRACK_HEIGHT),o=fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP);const r=yo.WITH_WEBLOGO()+o,s=yo.WITH_BOTH()+o;if(!(e<r))if(e<s){if(t){t.setVisible(!0);const n=e-r;t.setHeight(fo.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>s){const n=e-s;t.setHeight(fo.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<r&&t&&t.setVisible(!1),e<s&&n&&n.setVisible(!1))}}drawTrackButtons(){const e=70;if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),n=this.getTrack("weblogo"),i=this.getTrack("annotations"),o=t?.isVisible()??!1,r=n?.isVisible()??!1,s=i?.isVisible()??!1;let a=this.config.width-16;const l=this.config.headerHeight>=yo.WITH_TITLE()?(fo.TITLE_HEIGHT-14)/2:2;o&&r||(!o&&t&&(a-=e,this.drawTrackButton("conservation","Conservation",a,l,e,14),a-=4),!r&&n&&(a-=e,this.drawTrackButton("weblogo","WebLogo",a,l,e,14),a-=4)),!s&&i&&(a-=e,this.drawTrackButton("annotations","Annotations",a,l,e,14))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0)}snapToTrackHeight(e){const t=this.getTrack("annotations")?fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP:0;let n;if("annotations"===e)n=yo.WITH_TITLE()+t;else if("weblogo"===e)n=yo.WITH_WEBLOGO()+t;else{if("conservation"!==e)return;n=yo.WITH_BOTH()+t}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]="annotations"===t})),"annotations"===e?this.userSelectedTracks.annotations=!0:"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(n),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.getTrack("annotations")?fo.ANNOTATION_TRACK_HEIGHT+fo.TRACK_GAP:0,t=this.tracks.size>0?yo.WITH_BOTH()+e:yo.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=yo.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,fo.TITLE_HEIGHT),this.ctx.fillStyle=lo,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+fo.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof po&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0,l=this.config.headerHeight-fo.SLIDER_HEIGHT-fo.DOTTED_CELL_HEIGHT,c=l-fo.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[];this.tracks.forEach((e,t)=>{e.isVisible()&&d.push({id:t,track:e})});let m=c;for(const{id:e,track:t}of d){const i=m-t.getHeight();if(n>=i&&n<m){u=e,h=n-i;break}m=i-fo.TRACK_GAP}let p=null;if(u){const e=this.tracks.get(u);e&&(p=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==p)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=p,u)){const e=this.tracks.get(u);e instanceof po&&(e.setHovered(s,p),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||p!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=p,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,p);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=yo.WITH_TITLE();l&&fo.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-fo.SLIDER_HEIGHT,u=c-fo.DOTTED_CELL_HEIGHT,h=u-fo.TRACK_GAP,d=[],m=[];this.tracks.forEach((e,t)=>{e.isVisible()&&m.push({id:t,track:e})});let p=h;for(const{track:e}of m){const t=e.getHeight(),i=p-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),p=i-fo.TRACK_GAP}if(this.drawDottedCells(0,u,n,fo.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:fo.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+fo.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=lo,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,fo.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,fo.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,fo.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-fo.SLIDER_HEIGHT;return t>n&&t<n+fo.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-fo.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+fo.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.state.isDragging&&"header"===this.state.dragMode?this.eventElement.style.cursor="grabbing":this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)?this.eventElement.style.cursor="pointer":this.isInHeaderArea(e)?this.eventElement.style.cursor="grab":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(this.state.dragOccurred)return;if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=yo.WITH_TITLE()?fo.TITLE_HEIGHT:0,a=this.config.headerHeight-fo.SLIDER_HEIGHT-fo.DOTTED_CELL_HEIGHT,l=a-fo.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-fo.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=yo.WITH_TITLE()&&t&&(vo(e.left??0,n,i)||vo(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e);this.isInSliderDraggableArea(e)?(this.state.isDragging=!0,this.state.dragMode="slider",this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()):this.isInHeaderArea(e)&&!this.isInSliderArea(e)&&(this.state.isDragging=!0,this.state.dragMode="header",this.state.dragStartX=t,this.state.dragStartWindowPosition=this.config.windowStartPosition,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;if(this.state.dragOccurred=!0,"slider"===this.state.dragMode)this.handleSliderDrag(n);else if("header"===this.state.dragMode){const e=n-this.state.dragStartX,t=Math.round(e/this.config.positionWidth),i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-i+1;this.config.windowStartPosition=Math.max(1,Math.min(o,this.state.dragStartWindowPosition-t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1,this.state.dragMode="none",this.state.dragOccurred&&setTimeout(()=>{this.state.dragOccurred=!1},0)}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(this.state.dragOccurred)return;if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(this.isInsideColumnHeaderArea(t,n))this.seqColumn&&(o.shell.o=this.seqColumn);else if(n<this.config.headerHeight-fo.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:yo.BASE,WITH_TITLE:yo.WITH_TITLE(),WITH_WEBLOGO:yo.WITH_WEBLOGO(),WITH_BOTH:yo.WITH_BOTH()}}}function vo(e,t,n){return e>=t&&e<=n}class wo extends mo{constructor(e,t="Annotations"){super(20,14,t),this.tableCol=e,this.regions=[],this.posList=[],this._cacheVersion=-1,this._rebuildRegions()}hasRegions(){return this._ensureUpToDate(),this.regions.length>0}getRegionAtPosition(e){this._ensureUpToDate();for(const t of this.regions)if(e>=t.startIdx&&e<=t.endIdx)return t;return null}getTooltipContent(e,t){this._ensureUpToDate();const n=this.getRegionAtPosition(e);if(!n)return null;const i=n.sourceScheme??"",o=e<this.posList.length?this.posList[e]:"",s=[],a=document.createElement("b");return a.textContent=n.name,s.push(r.div([a],{style:{fontSize:"13px",marginBottom:"4px"}})),i&&s.push(r.divText(`Scheme: ${i}`,{style:{fontSize:"12px",color:"#555"}})),s.push(r.divText(`Range: ${n.startPos} – ${n.endPos}`,{style:{fontSize:"12px",color:"#555"}})),o&&s.push(r.divText(`Position: ${o}`,{style:{fontSize:"12px",color:"#555"}})),n.description&&s.push(r.divText(n.description,{style:{fontSize:"11px",color:"#888",marginTop:"2px"}})),r.divV(s,{style:{padding:"4px"}})}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible)return;if(this._ensureUpToDate(),0===this.regions.length)return;const l=this.ctx;l.save(),l.beginPath(),l.rect(e,t,n,i),l.clip();const c=o-1,u=c+Math.ceil(n/r)+2;for(const n of this.regions){if(n.endIdx<c||n.startIdx>u)continue;const o=Math.max(n.startIdx,c),s=e+(o-c)*r,a=(Math.min(n.endIdx,u)-o+1)*r;l.fillStyle=n.color,l.globalAlpha=.35,l.fillRect(s,t,a,i),l.globalAlpha=1,l.strokeStyle=n.color,l.globalAlpha=.6,l.lineWidth=1,l.strokeRect(s+.5,t+.5,a-1,i-1),l.globalAlpha=1,l.font="bold 9px Roboto, Roboto Local, sans-serif",a>l.measureText(n.name).width+4&&(l.fillStyle="#333",l.textAlign="center",l.textBaseline="middle",l.fillText(n.name,s+a/2,t+i/2))}l.restore()}_ensureUpToDate(){this._cacheVersion!==this.tableCol.version&&(this._rebuildRegions(),this._cacheVersion=this.tableCol.version)}_rebuildRegions(){this.regions=[];const e=this.tableCol.getTag(pe.gp.annotations);if(!e)return;let t;try{t=JSON.parse(e)}catch{return}if(this.posList=this._getPosList(),0!==this.posList.length)for(const e of t){if(e.category!==Et.eI.Structure)continue;if(null==e.start||null==e.end)continue;const t=this.posList.indexOf(e.start),n=this.posList.indexOf(e.end);t<0||n<0||this.regions.push({name:e.name,color:e.color??this._defaultColor(e),startIdx:t,endIdx:n,startPos:e.start,endPos:e.end,sourceScheme:e.sourceScheme,description:e.description})}}_getPosList(){const e=this.tableCol.getTag(pe.gp.positionNames);return e?e.split(", "):[]}_defaultColor(e){if(e.name.startsWith("CDR")){const t=parseInt(e.name.replace("CDR",""))-1;return Et.D5.structure.CDR[t%Et.D5.structure.CDR.length]}if(e.name.startsWith("FR")){const t=parseInt(e.name.replace("FR",""))-1;return Et.D5.structure.FR[t%Et.D5.structure.FR.length]}return"#90CAF9"}}class Co{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){Co.conservationCache=new s.LruCache(100),Co.webLogoCache=new s.LruCache(100),Co.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return Co.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return Co.conservationCache.getOrCreate(i,()=>{const o=Co.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return Co.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/Co.CHUNK_SIZE)*Co.CHUNK_SIZE,s=Math.ceil(n/Co.CHUNK_SIZE)*Co.CHUNK_SIZE;for(let t=r;t<s;t+=Co.CHUNK_SIZE){const n=Math.min(t+Co.CHUNK_SIZE,i),r=Co.getChunkCacheKey(e.column,t,n),s=Co.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/Co.CHUNK_SIZE)*Co.CHUNK_SIZE,s=Math.ceil(n/Co.CHUNK_SIZE)*Co.CHUNK_SIZE;for(let t=r;t<s;t+=Co.CHUNK_SIZE){const n=Math.min(t+Co.CHUNK_SIZE,i),r=Co.getChunkCacheKey(e.column,t,n),s=Co.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class Ao extends po{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=Co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=Co.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class So extends go{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=Co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=Co.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const xo="__msa-scroller-initialized",Eo="__msa-scroller-subscription";class Mo extends to.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return pe.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=Oe.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:pe.Hi.HELM})(n)}createCellRendererBack(e,t){const n=As.properties.maxMonomerLength||4,i=new To(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class To extends $e.Jy{constructor(e,t,n,i){super(e,t,As.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=$e.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:Oe.zS}})}}var Io,Lo,_o=n(6520),No={};No.styleTagTransform=C(),No.setAttributes=y(),No.insert=g().bind(null,"head"),No.domAPI=m(),No.insertStyleElement=v(),h()(_o.A,No),_o.A&&_o.A.locals&&_o.A.locals;class Po{view=null;libHelper=null;monomerLib=null;collectionNames=[];filteredNames=[];displayedCount=0;cardsContainer=null;loadMoreContainer=null;searchInput=null;currentUser="";collectionsCache=new Map;selectedCollections=new Set;cardElements=new Map;handler=new zn;static VIEW_NAME="Monomer Collections";async init(){this.libHelper=await bn.getInstance(),await this.libHelper.awaitLoaded(),this.monomerLib=this.libHelper.getMonomerLib(),this.currentUser=s.User.current().login,this.view=s.View.create(),this.view.name=Po.VIEW_NAME,this.view._mcView=this;const e=r.icons.add(()=>this.showAddCollectionDialog(),"Create new monomer collection"),t=r.iconFA("sync",()=>this.refresh(),"Refresh collections");return this.view.setRibbonPanels([[e,t]]),this.view.root.addEventListener("contextmenu",e=>{const t=e.target;if(t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card"))return;e.preventDefault();const n=s.Menu.popup();n.item("New Collection...",()=>this.showAddCollectionDialog()),n.item("Refresh",()=>this.refresh()),n.show()}),this.view.root.addEventListener("click",e=>{const t=e.target;t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card")||this.clearSelection()}),this.view.root.tabIndex=0,this.view.root.addEventListener("keydown",e=>{"Escape"===e.key&&this.clearSelection()}),await this.buildContent(),this.view}async buildContent(){if(!this.view)return;this.view.root.innerHTML="";const e=r.div([],{classes:"monomer-collections-view"});this.searchInput=r.input.string("Monomer Collections",{value:"",placeholder:"Search by name or tag..."}),this.searchInput.root.classList.add("monomer-collections-search");const t=this.searchInput.input;t.style.width="100%",t.style.marginBottom="12px";let n=null;t.addEventListener("input",()=>{n&&clearTimeout(n),n=setTimeout(()=>this.applyFilter(),250)}),this.cardsContainer=r.div([],{classes:"monomer-collections-grid"}),this.loadMoreContainer=r.div([],{classes:"monomer-collections-load-more"}),e.appendChild(this.searchInput.root),e.appendChild(this.cardsContainer),e.appendChild(this.loadMoreContainer),this.view.root.appendChild(e),await this.loadCollections()}async loadCollections(){try{this.collectionNames=await this.libHelper.listMonomerCollections()}catch(e){As.logger.error(`Error listing monomer collections: ${e instanceof Error?e.message:e.toString()}`),o.shell.error("Error loading monomer collections"),this.collectionNames=[]}this.collectionsCache.clear();for(const e of this.collectionNames)this.libHelper.readMonomerCollection(e).then(t=>{this.collectionsCache.set(e,t)}).catch(()=>{});this.applyFilter()}applyFilter(){const e=(this.searchInput?.value??"").trim().toLowerCase();this.filteredNames=e?this.collectionNames.filter(t=>{if(t.replace(/\.json$/i,"").toLowerCase().includes(e))return!0;const n=this.collectionsCache.get(t);return!!n?.tags?.some(t=>t.toLowerCase().includes(e))}):[...this.collectionNames],this.displayedCount=0,this.cardsContainer.innerHTML="",this.cardElements.clear(),this.showNextPage()}showNextPage(){const e=Math.min(this.displayedCount+19,this.filteredNames.length);for(let t=this.displayedCount;t<e;t++){const e=this.createCollectionCard(this.filteredNames[t]);this.cardsContainer.appendChild(e),this.cardElements.set(this.filteredNames[t],e)}this.displayedCount=e;const t=this.cardsContainer.querySelector(".monomer-collection-add-card");t&&t.remove(),this.cardsContainer.appendChild(this.createAddCard());const n=this.cardsContainer.querySelector(".monomer-collection-empty-state");if(n&&n.remove(),0===this.filteredNames.length){const e=0===this.collectionNames.length?'No monomer collections found. Click "+" to create one.':"No collections match your search.",t=r.div([r.divText(e)],{classes:"monomer-collection-empty-state"});this.cardsContainer.prepend(t)}if(this.loadMoreContainer.innerHTML="",this.displayedCount<this.filteredNames.length){const e=this.filteredNames.length-this.displayedCount,t=r.button(`Load more (${e} remaining)`,()=>this.showNextPage());this.loadMoreContainer.appendChild(t)}}createCollectionCard(e){const t=e.replace(/\.json$/i,""),n=r.div([t],{classes:"monomer-collection-card-title"});r.tooltip.bind(n,t);const i=r.div([n],{classes:"monomer-collection-card-header"}),a=r.div([],{classes:"monomer-collection-card-body"}),l=r.div([],{classes:"monomer-collection-card-actions"}),c=r.div([i,a,l],{classes:"monomer-collection-card"});c.dataset.collectionName=e,this.selectedCollections.has(e)&&c.classList.add("monomer-collection-card-selected"),c.addEventListener("click",t=>{const n=t.target;n.closest(".monomer-collection-card-actions")||n.closest(".monomer-collection-tag")||(t.stopPropagation(),this.handleCardClick(e,t.ctrlKey||t.metaKey))}),c.addEventListener("contextmenu",t=>{t.preventDefault(),t.stopPropagation(),this.selectedCollections.has(e)||this.handleCardClick(e,!1),this.showCardContextMenu(t)});const u=async()=>{const t=await this.libHelper.readMonomerCollection(e);if(this.collectionsCache.set(e,t),t.description){const e=r.div([t.description],{classes:"monomer-collection-card-description"});r.tooltip.bind(e,t.description),i.appendChild(e)}if(t.tags&&t.tags.length>0){const e=r.div([],{classes:"monomer-collection-card-tags"});for(const n of t.tags){const t=r.div([n],{classes:"monomer-collection-card-tag"});e.appendChild(t)}i.appendChild(e)}const n=[];if(t.updatedBy&&n.push(`by ${t.updatedBy}`),t.updatedOn)try{n.push(new Date(t.updatedOn).toLocaleDateString())}catch{}n.length>0&&i.appendChild(r.div([n.join(" | ")],{classes:"monomer-collection-card-meta"}));const a=r.div([],{classes:"monomer-collection-tags"}),c=t.monomerSymbols??[];for(const e of c){const t=r.div([e],{classes:"monomer-collection-tag"});t.addEventListener("mouseenter",()=>{if(this.monomerLib){const n=this.getMonomerTooltipSafe(e);if(n){const e=t.getBoundingClientRect();r.tooltip.show(n,e.left,e.bottom+4)}}}),t.addEventListener("mouseleave",()=>r.tooltip.hide()),t.addEventListener("click",t=>{t.stopPropagation(),o.shell.o=s.SemanticValue.fromValueType(e,Ve.uF.MONOMER)}),a.appendChild(t)}const u=r.divText(`${c.length} monomer(s)`,{style:{fontSize:"11px",color:"var(--grey-4)",marginBottom:"6px"}}),h=r.divV([u,a]),d=t.updatedBy===this.currentUser,m=r.button("Edit",()=>{d&&this.showEditCollectionDialog(e,t)}),p=r.button("Delete",()=>{d&&this.confirmDeleteCollection(e)});if(!d){for(const e of[m,p])e.style.opacity="0.4",e.style.cursor="default";r.tooltip.bind(m,"Only the author can edit"),r.tooltip.bind(p,"Only the author can delete")}return l.appendChild(m),l.appendChild(p),h};return a.appendChild(r.wait(()=>u())),c}handleCardClick(e,t){t?this.selectedCollections.has(e)?this.selectedCollections.delete(e):this.selectedCollections.add(e):(this.selectedCollections.clear(),this.selectedCollections.add(e)),this.updateCardSelectionStyles(),this.setCurrentObject()}clearSelection(){this.selectedCollections.clear(),this.updateCardSelectionStyles()}updateCardSelectionStyles(){for(const[e,t]of this.cardElements)this.selectedCollections.has(e)?t.classList.add("monomer-collection-card-selected"):t.classList.remove("monomer-collection-card-selected")}async setCurrentObject(){const e=[...this.selectedCollections];if(0===e.length)return;const t=[];for(const n of e){let e=this.collectionsCache.get(n);if(!e)try{e=await this.libHelper.readMonomerCollection(n)}catch{continue}t.push({name:n,displayName:n.replace(/\.json$/i,""),data:e})}1===t.length?o.shell.o=t[0]:t.length>1&&(o.shell.o=t)}showCardContextMenu(e){const t=s.Menu.popup(),n=[...this.selectedCollections];if(n.length<=1&&n.length>0){const e=n[0],i=this.collectionsCache.get(e);if(i){const n={name:e,displayName:e.replace(/\.json$/i,""),data:i};zn.buildContextMenu(t,n,this.handler)}}else if(n.length>1){const e=n.map(e=>{const t=this.collectionsCache.get(e);return t?{name:e,displayName:e.replace(/\.json$/i,""),data:t}:null}).filter(e=>null!==e);e.length>0&&zn.buildMultiContextMenu(t,e,this.handler)}t.show()}getMonomerTooltipSafe(e){if(!this.monomerLib)return null;const t=[Be.o.AA,Be.o.NUCLEOTIDE,Be.o.CHEM,Be.o.BLOB];for(const n of t)try{if(this.monomerLib.getWebEditorMonomer(n,e))return this.monomerLib.getTooltip(n,e)}catch(e){}return null}createAddCard(){const e=r.iconFA("plus",()=>{},"");e.style.fontSize="32px",e.style.marginBottom="8px";const t=r.span(["New Collection"]),n=r.div([e,t],{classes:"monomer-collection-add-card-content"}),i=r.div([n],{classes:"monomer-collection-add-card"});return i.addEventListener("click",()=>this.showAddCollectionDialog()),i}showAddCollectionDialog(){const e=r.input.string("Name",{nullable:!1,placeholder:"Enter collection name"}),t=r.input.string("Description",{nullable:!0,placeholder:"Optional description"}),n=r.input.string("Tags",{nullable:!0,placeholder:"Comma-separated tags"}),i=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),s=new Wn(this.monomerLib,i.value,[],this.libHelper);i.onChanged.subscribe(()=>{s.setPolymerType(i.value)}),r.dialog({title:"New Monomer Collection"}).add(r.divV([e,t,n,i,r.element("hr"),s.root])).onOK(async()=>{const i=e.value?.trim();if(!i)return void o.shell.warning("Collection name is required");const r=s.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const a=Ro(n.value);try{await this.libHelper.addOrUpdateMonomerCollection(i,r,t.value??void 0,a.length>0?a:void 0),o.shell.info(`Collection "${i}" created successfully`),await this.refresh()}catch(e){o.shell.error("Error creating collection"),As.logger.error(`Error creating collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",s.focus()}editCollectionPublic(e,t){this.showEditCollectionDialog(e,t)}showEditCollectionDialog(e,t){const n=e.replace(/\.json$/i,""),i=r.input.string("Name",{value:n,nullable:!1}),s=r.input.string("Description",{value:t.description??"",nullable:!0}),a=r.input.string("Tags",{value:(t.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(this.monomerLib,l.value,[...t.monomerSymbols??[]],this.libHelper);l.onChanged.subscribe(()=>{c.setPolymerType(l.value)}),r.dialog({title:`Edit Collection: ${n}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const t=i.value?.trim();if(!t)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=Ro(a.value);try{t!==n&&await this.libHelper.deleteMonomerCollection(e),await this.libHelper.addOrUpdateMonomerCollection(t,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${t}" saved successfully`),await this.refresh()}catch(e){o.shell.error("Error saving collection"),As.logger.error(`Error saving collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",c.focus()}confirmDeleteCollection(e){const t=e.replace(/\.json$/i,"");r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete the collection "${t}"?`)).onOK(async()=>{try{await this.libHelper.deleteMonomerCollection(e),o.shell.info(`Collection "${t}" deleted`),await this.refresh()}catch(e){o.shell.error("Error deleting collection"),As.logger.error(`Error deleting collection: ${e instanceof Error?e.message:e.toString()}`)}}).show()}async refresh(){this.selectedCollections.clear(),await this.loadCollections()}}function Ro(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}class $o{colInput;constructor(e,t){const n=t.filter;this.colInput=r.input.column(e,{...t,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE&&(!n||n(e))});const i=r.iconFA("cut",()=>this.onRegionIconClick(),"Extract a region from the sequence");this.colInput.addOptions(i)}static create(e,t){return new $o(e,t)}get root(){return this.colInput.root}get value(){return this.colInput.value}set value(e){this.colInput.value=e}get inputBase(){return this.colInput}onRegionIconClick(){const e=this.colInput.value;e?function(e,t){const n=As.seqHelper.getSeqHandler(e),i=r.input.string("Name",{value:""}),a=r.input.choice("Start Position",{value:n.posList[0],items:n.posList,onValueChanged:()=>h()}),l=r.input.choice("End Position",{value:n.posList[n.posList.length-1],items:n.posList,onValueChanged:()=>h()});let c=null;const u=()=>c?`${e.name}(${c}): ${a.value}-${l.value}`:`${e.name}:${a.value}-${l.value}`,h=()=>{i.value||i.input.setAttribute("placeholder",u())};h();const d=function(e,t,n,i){let o=null;const s=e.getTag(ue.gp.annotations);if(s)try{const e=JSON.parse(s).filter(e=>e.category===Et.eI.Structure&&e.start&&e.end);e.length>0&&(o=e.map(e=>({name:e.name,start:e.start,end:e.end})))}catch{}if(!o){const t=e.getTag(ue.gp.regions);if(t)try{o=JSON.parse(t)}catch{}}if(!o||0===o.length)return null;const a=["",...o.map(e=>`${e.name}: ${e.start}-${e.end}`)];return r.input.choice("Region",{value:"",items:a,onValueChanged:e=>{if(!e)return void i?.(null);const r=o.find(t=>`${t.name}: ${t.start}-${t.end}`===e);r&&(t.value=r.start,n.value=r.end,i?.(r.name))}})}(e,a,l,e=>{c=e,h()}),m=[];d&&m.push(d),m.push(i,a,l);const p=r.dialog({title:"Get Region"}).add(r.inputs(m)).onOK(()=>{const n=s.TaskBarProgressIndicator.create("Getting region...");try{const n=i.value||u(),o=Li(e,a.value,l.value,n);e.dataFrame.columns.add(o),o.setTag(s.TAGS.CELL_RENDERER,"sequence"),t?.(o)}catch(e){o.shell.error(e.toString())}finally{n.close()}});p.show()}(e,e=>{this.colInput.value=e}):o.shell.warning("Select a macromolecule column first.")}}async function Oo(){return await xs.getMonomerLibHelper()}async function ko(){await xs.initBio()}function Ho(e){return xs.sequenceTooltip(e)}async function Bo(e){return await xs.standardiseMonomerLibrary(e)}async function Fo(e,t,n){await xs.matchWithMonomerLibrary(e,t,n)}function Do(){return xs.getBioLib()}function Go(e){return xs.getSeqHandler(e)}function Vo(e){return xs.getRegionPanel(e)}async function qo(e){return await xs.libraryPanel(e)}function jo(e){xs.GetRegionEditor(e)}function Uo(e){xs.SplitToMonomersEditor(e)}function Wo(e){xs.SequenceSpaceEditor(e)}function zo(e){xs.SeqActivityCliffsEditor(e)}function Yo(){return xs.customSequenceCellRenderer()}function Ko(){return xs.fastaSequenceCellRenderer()}function Zo(){return xs.separatorSequenceCellRenderer()}function Xo(){return xs.bilnSequenceCellRenderer()}function Jo(e,t,n){return xs.refineNotationProviderForBiln(e,t,n)}function Qo(e){return xs.macroMolColumnPropertyPanel(e)}function er(e){return xs.compositionAnalysisWidget(e)}function tr(e){return xs.monomerInfoPanel(e)}function nr(){return xs.macromoleculeDifferenceCellRenderer()}function ir(e,t,n,i,o){return xs.sequenceAlignment(e,t,n,i,o)}function or(){return xs.webLogoViewer()}function rr(){return xs.vdRegionsViewer()}function sr(e,t,n,i){return xs.getRegion(e,t,n,i)}async function ar(e,t,n,i,o){await xs.getRegionTopMenu(e,t,n,i,o)}function lr(){xs.applyNumberingScheme()}function cr(){xs.scanLiabilities()}function ur(){xs.manageAnnotations()}function hr(e,t){return xs.sequenceColumnInput(e,t)}async function dr(e,t,n,i,o,r,s,a,l){return await xs.activityCliffs(e,t,n,i,o,r,s,a,l)}async function mr(e){await xs.seqActivityCliffsInitFunction(e)}async function pr(e,t,n,i,o,r,s,a,l){await xs.seqActivityCliffsTransform(e,t,n,i,o,r,s,a,l)}async function gr(e,t,n,i,o){return await xs.macromoleculePreprocessingFunction(e,t,n,i,o)}async function fr(e,t){return await xs.helmPreprocessingFunction(e,t)}async function yr(e,t,n,i,o,r,s,a,l){return await xs.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function br(e,t,n,i,o,r,s,a,l){return await xs.sequenceSpaceTransform(e,t,n,i,o,r,s,a,l)}async function vr(e,t){await xs.moleculesToHelmTopMenu(e,t)}async function wr(e){return await xs.moleculeToHelmSingle(e)}async function Cr(e,t,n,i){await xs.toAtomicLevel(e,t,n,i)}async function Ar(e){await xs.toAtomicLevelAction(e)}async function Sr(e){return await xs.toAtomicLevelPanel(e)}async function xr(e){return await xs.toAtomicLevelSingleSeq(e)}async function Er(e){return await xs.sequence3dStructureWidget(e)}function Mr(){xs.multipleSequenceAlignmentDialog()}async function Tr(e,t,n){return await xs.alignSequences(e,t,n)}async function Ir(e,t,n,i){return await xs.pepseaMsa(e,t,n,i)}async function Lr(){return await xs.compositionAnalysis()}function _r(e){return xs.importFasta(e)}function Nr(e){return xs.importBam(e)}function Pr(){xs.convertDialog()}function Rr(e){xs.convertColumnAction(e)}function $r(){return xs.monomerCellRenderer()}async function Or(e){return await xs.testDetectMacromolecule(e)}async function kr(e,t){return await xs.splitToMonomersTopMenu(e,t)}function Hr(e){return xs.getHelmMonomers(e)}function Br(){return xs.similaritySearchViewer()}function Fr(){return xs.similaritySearchTopMenu()}function Dr(){return xs.diversitySearchViewer()}function Gr(){return xs.diversitySearchTopMenu()}function Vr(e){xs.searchSubsequenceEditor(e)}function qr(e){xs.SubsequenceSearchTopMenu(e)}async function jr(e,t,n){return await xs.sequenceIdentityScoring(e,t,n)}async function Ur(e,t,n){return await xs.sequenceSimilarityScoring(e,t,n)}async function Wr(){await xs.manageMonomerLibraries()}async function zr(){await xs.manageLibrariesView()}async function Yr(){await xs.manageMonomersView()}async function Kr(e){return await xs.manageMonomerLibrariesView(e)}async function Zr(e){await xs.manageMonomerLibrariesViewTreeBrowser(e)}async function Xr(){return await xs.monomerCollectionsApp()}function Jr(){xs.saveAsFasta()}function Qr(){return xs.bioSubstructureFilter()}function es(){return xs.bioSubstructureFilterTest()}async function ts(){await xs.webLogoLargeApp()}async function ns(){await xs.webLogoAggApp()}async function is(){await xs.getRegionApp()}async function os(){await xs.getRegionHelmApp()}function rs(){xs.longSeqTableSeparator()}function ss(){xs.longSeqTableFasta()}function as(){xs.longSeqTableHelm()}function ls(e,t){xs.addCopyMenu(e,t)}async function cs(){await xs.demoBioSimilarityDiversity()}async function us(){await xs.demoBioSequenceSpace()}async function hs(){await xs.demoBioActivityCliffs()}async function ds(){await xs.demoBioAtomicLevel()}async function ms(e){await xs.sdfToJsonLib(e)}async function ps(e,t){return await xs.seq2atomic(e,t)}async function gs(e,t){return await xs.seqIdentity(e,t)}async function fs(e,t,n){await xs.detectMacromoleculeProbe(e,t,n)}async function ys(){return await xs.getSeqHelper()}async function bs(e,t,n){return await xs.getMolFromHelm(e,t,n)}!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryFile:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(Io||(Io={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.monomerInfoPanel=async function(e){return await o.functions.call("Bio:MonomerInfoPanel",{monomerSv:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.applyNumberingScheme=async function(){return await o.functions.call("Bio:ApplyNumberingScheme",{})},e.scanLiabilities=async function(){return await o.functions.call("Bio:ScanLiabilities",{})},e.manageAnnotations=async function(){return await o.functions.call("Bio:ManageAnnotations",{})},e.sequenceColumnInput=async function(e,t){return await o.functions.call("Bio:SequenceColumnInput",{name:e,options:t})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.seqActivityCliffsInitFunction=async function(e){return await o.functions.call("Bio:SeqActivityCliffsInitFunction",{sp:e})},e.seqActivityCliffsTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SeqActivityCliffsTransform",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,options:a,isDemo:l,axesNames:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.sequenceSpaceTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTransform",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,options:s,clusterEmbeddings:a,embedColsNames:l,clusterColName:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.pepseaMsa=async function(e,t,n,i){return await o.functions.call("Bio:PepseaMsa",{sequenceCol:e,method:t,gapOpen:n,gapExtend:i})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesView",{path:e})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.monomerCollectionsApp=async function(){return await o.functions.call("Bio:MonomerCollectionsApp",{})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(Lo||(Lo={}));var vs=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},ws=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Cs=function(e,t){return function(n,i){t(n,i,e)}};const As=new Si;let Ss=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class xs{static async getMonomerLibHelper(){return await bn.getInstance()}static async initBio(){null==Ss&&(Ss=async function(){const e="Bio: _package.initBio()";As.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,_e.j)(),i=await As.getProperties(),r=new Ai(i);As.properties=r;const a=await bn.getInstance(),l=await(0,Le.u)();l.explicit&&(l.explicit=[],await(0,Le.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();As.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new so(a,n);As.completeInit(m,u,h,n),s.ObjectHandler.register(new zn),As.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[Eo]||(t.temp[Eo]=[]);let i=t.temp[Eo];i.forEach(e=>e.unsubscribe()),t.temp[Eo]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[xo];i.temp[xo]=!0;let l=null;try{l=As.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>$e.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],v=l.splitter(b),w=v?v.length:30,C=e.getTag(ue.gp.annotations)?24:0,A={WITH_TITLE:58,WITH_WEBLOGO:107+C,WITH_BOTH:156+C};let S;S=e.length>1e5||w<50?A.WITH_TITLE+C:e.length>5e4?A.WITH_WEBLOGO:A.WITH_BOTH;let x=null,E=null;const M=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{Co.clearAllCaches(),x&&(x.resetViewportTracking(),x.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(M);const T=o=>{const c=[],h=new wo(e,"Annotations");h.hasRegions()&&c.push({id:"annotations",track:h,priority:0});const g=new Ao(l,w,45,"WebLogo");x=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:1});const f=new So(l,w,45,"default","Conservation");E=f,c.push({id:"conservation",track:f,priority:2});const y=new bo({canvas:t.overlay,headerHeight:S,totalPositions:w+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<A.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);y.setupTooltipHandling(),c.sort((e,t)=>e.priority-t.priority),c.forEach(({id:e,track:t})=>{y.addTrack(e,t)}),y.setSelectionData(n,e,l),w>50&&!a&&(t.props.colHeaderHeight=S,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>y.detach()});const b=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==b?.dart)return;const i=t.bounds;if(!i)return;y.headerHeight=i.height;const o=p();y.positionWidth=o+8;const r=d();y.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();T(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Ss}static sequenceTooltip(e){const t=new Ti(e,As.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Tn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await Tn(l);c.forEach((e,t)=>{e.lib=l[t].lib});const{cappedMap:u,uncappedMap:h}=await async function(e,t,n){const i={};for(const t of e){if(!t.smiles)continue;const e={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source??""};i[t.smiles]||(i[t.smiles]=[]),i[t.smiles].push(e)}const o=e.map((e,n)=>({symbol:e.symbol,smiles:Bn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:t[n]?.lib?.source??""})).filter(e=>!!e.smiles&&!e.smiles.includes("[*:")),r=s.Column.fromList(s.COLUMN_TYPE.STRING,"CappedSmiles",o.map(e=>e.smiles));r.semType=s.SEMTYPE.MOLECULE;const a=await n.apply({molecule:r,targetNotation:s.chem.Notation.Smiles});if(!a||a.length!==r.length)throw new Error("Error canonicalizing capped monomer SMILES");const l={},c=a.toList();for(let e=0;e<c.length;e++){const t=c[e];if(!t)continue;o[e].smiles=t;const n=o[e];l[t]||(l[t]=[]),l[t].push(n)}return{cappedMap:l,uncappedMap:i}}(c,l,a),d=await async function(e,t,n){const i=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return kn([],t?void 0:e,t?e:void 0)}catch(t){return e}}),o=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesCorrected",i);o.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([o]);const r=await n.apply({molecule:o,targetNotation:s.chem.Notation.Smiles});if(!r||r.length!==o.length)throw new Error("Error canonicalizing molecules");return r.toList()}(e,t,a),m=new Array(d.length).fill(null).map(()=>[]),p=[];for(let e=0;e<d.length;e++){const t=d[e];if(!t)continue;const n=An(t,u,h);n.length>0?m[e]=n:p.push(e)}if(p.length>0)try{const{fpMap:e}=await async function(e){const t=Object.keys(e);if(0===t.length)return{fpMap:{},cappedSmilesList:[]};const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",t);n.semType=s.SEMTYPE.MOLECULE;const i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r={};for(let n=0;n<i.length;n++){const o=i.get(n);if(!o)continue;const s=o.toBinaryString(),a=e[t[n]]??[];r[s]||(r[s]=[]),r[s].push(...a)}return{fpMap:r,cappedSmilesList:t}}(u),t=await async function(e,t,n){const i=new Map;if(0===e.length||0===Object.keys(n).length)return i;const r=e.map(e=>t[e]??""),a=r.map(e=>{if(!e)return"";const t=Bn(e,Cn);return t!==e?o.chem.convert(t,s.chem.Notation.Unknown,s.chem.Notation.Smiles):e}),l=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMols",r);l.semType=s.SEMTYPE.MOLECULE;const c=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMolsCapped",a);c.semType=s.SEMTYPE.MOLECULE;const[u,h]=await Promise.all([o.functions.call("Chem:getMorganFingerprints",{molColumn:l}),o.functions.call("Chem:getMorganFingerprints",{molColumn:c})]);for(let t=0;t<e.length;t++){const o=e[t],r=u.get(t);if(r){const e=n[r.toBinaryString()];if(e&&e.length>0){i.set(o,e);continue}}const s=h.get(t);if(s){const e=n[s.toBinaryString()];e&&e.length>0&&i.set(o,e)}}return i}(p,d,e);for(const[e,n]of t)m[e]=n}catch(e){console.warn("Fingerprint fallback matching failed, continuing with SMILES matches only:",e)}const g=e.clone(),f=g.columns.addNewString(g.columns.getUnusedName("Matched monomer symbol")),y=g.columns.addNewString(g.columns.getUnusedName("Matched monomer smiles"));y.semType=s.SEMTYPE.MOLECULE;const b=g.columns.addNewString(g.columns.getUnusedName("Matched monomer source")),v=g.columns.addNewInt(g.columns.getUnusedName("Match count")),w=g.columns.addNewString(g.columns.getUnusedName("Match method"));g.columns.setOrder([t,f.name,y.name,b.name,v.name,w.name]);for(let e=0;e<m.length;e++){const t=m[e];if(0===t.length)continue;const n=Sn(t),i=xn(n,r);f.set(e,n.map(e=>e.symbol).join(" | "),!1),y.set(e,n[0].original??n[0].smiles,!1),b.set(e,i,!1),v.set(e,n.length,!1);const o=p.includes(e)?"fingerprint":"exact";w.set(e,o,!1)}return g}(e,t.name,As.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return As.monomerLib}static getSeqHandler(e){return As.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:As.name,name:t});if(1!==n.length)throw new Error(`Package '${As.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new Pi(i,As.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Kn()(e).addClass("d4-link-action"),e.onclick=async()=>await ti(),new s.Widget(e)}()}static GetRegionEditor(e){try{new Pi(e,As.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),As.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new fi;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new P({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Ce({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new Ue}static fastaSequenceCellRenderer(){return new Ue}static separatorSequenceCellRenderer(){return new Ue}static bilnSequenceCellRenderer(){return new Ue}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[me.j.notationProvider]=new Mo(n,As.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let i=As.properties?As.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));i=isNaN(t)?i:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);i=isNaN(t)?i:t}const o=r.input.int("Max Monomer Length",{value:i,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{o.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let a=As.properties?As.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(a=e.temp[".mm.cellRenderer.fontSize"]);const l=r.input.int("Font Size",{value:a,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),c=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Fe.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),u=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),d=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let m=null;e.meta.units!==ue.Hi.HELM&&(m=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[l,o,c,h,u,d];m&&p.push(m);const g=r.inputs(p),f=(0,xt.Ln)(e),y=r.divV([]);if(f.length>0){const t=e.getTag(ue.gp.numberingScheme),i=f.filter(e=>e.category===Et.eI.Structure),o=f.filter(e=>e.category===Et.eI.Liability);if(t&&y.append(r.divText(`Numbering: ${t}`,{style:{fontSize:"12px",marginBottom:"4px"}})),i.length>0){const e=i.map(e=>e.name).join(", ");y.append(r.divText(`Regions: ${e}`,{style:{fontSize:"12px",marginBottom:"4px"}}))}if(o.length>0){const e=o.reduce((e,t)=>{const n=t.description?.match(/\((\d+) hits\)/);return e+(n?parseInt(n[1]):0)},0);y.append(r.divText(`Liabilities: ${o.length} rules (${e} hits)`,{style:{fontSize:"12px",marginBottom:"4px"}}))}const s=r.button("Manage",()=>{n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}),a=r.button("Clear All",()=>{(0,xt.OW)(e.dataFrame,e),e.dataFrame.fireValuesChanged()});y.append(r.divH([s,a],{style:{gap:"4px",marginTop:"4px"}}))}else{y.append(r.divText("No annotations",{style:{fontSize:"12px",color:"#888"}}));const e=r.button("Scan Liabilities",()=>{n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}),t=r.button("Apply Numbering",()=>{n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())});y.append(r.divH([e,t],{style:{gap:"4px",marginTop:"4px"}}))}const b=r.accordion();return b.addPane("Renderer Settings",()=>g),b.addPane("Annotations",()=>y),new s.Widget(b.root)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?Be.o.NUCLEOTIDE:Be.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===Be.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,Oe.MD)(n)}});const m=(0,xi.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,As.monomerLib,As.seqHelper)}static monomerInfoPanel(e){return function(e,t){const n=e.value;if(!n)return new s.Widget(r.divText("No monomer value."));const i=function(e){try{const t=e.cell?.column;if(t)return t.temp[pe.sc]??null}catch{}return null}(e),o=(i?i.canonicalize(n):n).split(pe.ot).map(e=>e.trim()).filter(e=>e.length>0).map(e=>({symbol:e,monomer:t.getMonomer(null,e)})).filter(e=>null!==e.monomer);if(0===o.length)return new s.Widget(r.divText(`Monomer '${n}' not found in the library.`));const a=r.accordion("Monomer");if(1===o.length){const e=o[0].monomer;a.addPane("Details",()=>Gn(e),!0),a.addPane("Molecule",()=>Vn(e),!0)}else for(const{symbol:e,monomer:t}of o)a.addPane(e,()=>r.divV([Gn(t),r.element("hr"),Vn(t)]),!0);return new s.Widget(a.root)}(e,As.monomerLib)}static macromoleculeDifferenceCellRenderer(){return new ze}static sequenceAlignment(e,t,n,i,o){const r=new ct(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new tt.oP}static vdRegionsViewer(){return new st}static getRegion(e,t,n,i){return Li(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=Li(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static applyNumberingScheme(){n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())}static scanLiabilities(){n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}static manageAnnotations(){n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}static sequenceColumnInput(e,t){return $o.create(e,t)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(Ne(e),!(0,hi.V)(t,"Activity Cliffs"))return;const p=c===l.c.UMAP?2e5:2e4,g=c===l.c.UMAP?5e3:2e3;if(e.rowCount>p)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${p}`);const f=Ee(e),y=async()=>{await s.Func.find({name:"seqActivityCliffsTransform"})[0].prepare({table:e,molecules:t,activities:n,similarity:i,methodName:c,similarityMetric:u,options:JSON.stringify(d),isDemo:m,axesNames:f}).call(void 0,void 0,{processed:!1}),Ne(e);const r=o.shell.tv,a=`Molecules: ${t.name}, activities: ${n.name}, method: ${c}, ${d?`options: ${JSON.stringify(d)},`:""} similarity: ${u}, similarity cutoff: ${i}`;r.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:f[0],yColumnName:f[1],color:n.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:"Activity cliffs",initializationFunction:"seqActivityCliffsInitFunction",description:a,descriptionVisibilityMode:"Never"})},b=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");try{e.rowCount>g&&!d?.[a.vb]?await new Promise((e,t)=>{r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{y().then(()=>e()).catch(e=>t(e))}).onCancel(()=>{e()}).show()}):await y()}catch(e){const[t,n]=(0,ve.AP)(e);throw As.logger.error(t,void 0,n),e}finally{b.close()}}static async seqActivityCliffsInitFunction(e){const t=e.dataFrame.getTag("seqActivityCliffsParams");if(!t)return void o.shell.error("Sequence activity cliffs parameters not found in table tags");const n=JSON.parse(t),i=e.dataFrame.col(n.seqColName),r=e.dataFrame.col(n.activityColName),a=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],l=await a.apply({col:i,metric:n.similarityMetric}),c=[e.getOptions().look.xColumnName,e.getOptions().look.yColumnName],u={units:i.meta.units,aligned:i.getTag(ue.gp.aligned),separator:i.getTag(ue.gp.separator),alphabet:i.getTag(ue.gp.alphabet)};await le(e,e.dataFrame,i,l,r,c,n.similarity,n.similarityMetric,n.options??{},s.SEMTYPE.MACROMOLECULE,u,dt,mt,yt,void 0,n.isDemo)}static async seqActivityCliffsTransform(e,t,i,o,r,a,l,c,u){await e.meta.detectSemanticTypes();const h=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];u||(u=Ee(e)),await async function(e,t,i,o,r,s,a,l){const c=l.inputs,u=await l.apply({[c[0].name]:t,[c[1].name]:r,...a.preprocessingFuncArgs??{}});let h=[];if(s===_){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([u.entries],o,[1],"MANHATTAN",[r],[u.options??{}],a?.maxIterations??5,a.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),h=[t.embedX,t.embedY]}else h=await U([u.entries],s,[r],[1],"MANHATTAN",{...a,distanceFnArgs:[u.options??{}]});if(h.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<h.length;++t)e.columns.addNewFloat(i[t]).init(e=>h[t][e])}(e,t,u,o,a,r,JSON.parse(l??"{}"),h);const d={seqColName:t.name,activityColName:i.name,similarityMetric:a,similarity:o,options:l??{},isDemo:c};e.setTag("seqActivityCliffsParams",JSON.stringify(d))}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ut(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ht.BQ)(e,As.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=D.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,a,l,c,u){if(Ne(e),!(0,hi.V)(t,"Sequence Space"))return;const h=e.columns.getUnusedName("Cluster (DBSCAN)"),d=Ee(e);let m;if(await s.Func.find({name:"sequenceSpaceTransform"})[0].prepare({table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:!1,options:JSON.stringify(l),clusterEmbeddings:c,embedColsNames:d,clusterColName:h}).call(void 0,void 0,{processed:!1}),r){Ne(e),m=o.shell.tv.scatterPlot({x:d[0],y:d[1],title:"Sequence space"});const r=`Molecules column: ${t.name}, method: ${n}, ${l?`options: ${JSON.stringify(l)},`:""} similarity: ${i}`;m.setOptions({description:r,descriptionVisibilityMode:"Never"}),c&&(m.props.colorColumnName=h)}return m}static async sequenceSpaceTransform(e,t,n,i,r,l,c,u,h){await e.meta.detectSemanticTypes();const d=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],m=JSON.parse(l??"{}"),p=o.shell.tv?.dataFrame==e?o.shell.tv:void 0;return await Te(e,[t],n,[i],[1],[d],"MANHATTAN",r,c??!1,{...m,preprocessingFuncArgs:[m.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:m?.[a.vb],tableView:p,embedColsNames:u,clusterColName:h})}static async moleculesToHelmTopMenu(e,t){const n=As.monomerLib,i=JSON.stringify(n.toJSON()),o=s.FileInfo.fromString("monomerLib.json",i);await Io.molToHelmConverterPy(e,t,o);const r=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);r&&(r.meta.units=ue.Hi.HELM,r.semType=s.SEMTYPE.MACROMOLECULE,r.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await xs.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ss;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??As.monomerLib,r=As.seqHelper,s=As.rdKitModule;await(0,Ri.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await ao(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){As.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await ao(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await ao(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=Hi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,mi.D)({},As.seqHelper).catch(e=>{const[t,n]=(0,ve.AP)(e);if(e instanceof di.Ap)return o.shell.warning(e.element),void As.logger.warning(t);o.shell.error(t),As.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,mi.D)({col:e,clustersCol:t,...n},As.seqHelper)}static async pepseaMsa(e,t="mafft --auto",n=1.53,i=0){return(0,pi.Gf)(e,t,n,i)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(As.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,hi.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>As.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Pe.me)()[0];(0,St.C)(e,As.seqHelper)}static convertColumnAction(e){(0,St.C)(e,As.seqHelper)}static monomerCellRenderer(){return new wi}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await s.delay(10),!(0,hi.V)(t,"Sequence space"))return e;const n=ge(t,As.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ve.uF.MONOMER,e.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ve.uF.MONOMER,o.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return As.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new Ct(As.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new At(As.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Pe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ht.a7(t,As.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=As.seqHelper;return $i(e,t,n,fe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=As.seqHelper;return $i(e,t,n,fe.SIMILARITY,i)}static async manageMonomerLibraries(){ti()}static async manageLibrariesView(){await ni()}static async manageMonomersView(){const e=await Ln.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(e){const t=await ni(!1);return t.parentCall=o.functions.getCurrentCall(),t}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await bn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await Ln.getInstance();(await e.getViewRoot(t,!0)).parentCall=o.functions.getCurrentCall(),e.resetCurrentRowFollowing()})})}static async monomerCollectionsApp(){return await async function(e=!0){if(e){const e=Array.from(o.shell.views).find(e=>e.name===Po.VIEW_NAME);if(e)return o.shell.v=e,e}const t=new Po,n=await t.init();return e&&o.shell.addView(n),n}(!1)}static saveAsFasta(){(0,qn.TE)()}static bioSubstructureFilter(){return new jn._i(As.seqHelper,As.logger)}static bioSubstructureFilterTest(){return new jn._i(As.seqHelper,As.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"webLogoLargeApp"),n=await As.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"webLogoAggApp"),n=await As.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Ni(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await As.files.readCsv("samples/HELM_empty_vals.csv"),n=new Ni(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,Ie.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(As.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(As.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,i){const r=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(r,t=>{const n=e.column,r=e.rowIndex,s=i.getSeqHandler(n),a=t===ue.Hi.SEPARATOR?As.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")});const s=e.column,a=(0,xt.Ln)(s);if(a.length>0&&new Ii.$(s).hasAnnotations()){const e=a.filter(e=>e.category===Et.eI.Structure);if(e.length>0){const r=t.group("Annotations");for(const t of e)t.start&&t.end&&r.item(`Extract ${t.name} as Column`,()=>{n.e(288).then(n.bind(n,9288)).then(e=>{try{e.extractAnnotatedRegion(s.dataFrame,s,t.name,i)}catch(e){o.shell.error(`Failed to extract region: ${e.message??e}`)}})});a.filter(e=>e.category===Et.eI.Liability).length>0&&r.item("Filter: Rows with Liability Hits",()=>{n.e(288).then(n.bind(n,9288)).then(e=>{e.filterByLiabilityHits(s.dataFrame,s)})})}}}(e,t,As.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await As.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Pe.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await As.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await xs.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Kn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),As.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await As.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await xs.toAtomicLevel(e,n,!0,!1),(0,Pe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Pe.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?xs.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await $i(i,n,t,fe.IDENTITY,As.seqHelper)).get(0)}catch(e){const[t,n]=(0,ve.AP)(e);throw As.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await s.delay(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await xs.initBio(),As.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=As.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,As.rdKitModule,i);return r.semType=s.SEMTYPE.MOLECULE,r}(0,t,n,As.monomerLib)}}vs([o.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getMonomerLibHelper",null),vs([o.decorators.init({tags:["init"]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"initBio",null),vs([o.decorators.func({meta:{role:"tooltip"},tags:["tooltip"]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"sequenceTooltip",null),vs([o.decorators.func({}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"standardiseMonomerLibrary",null),vs([o.decorators.func({"top-menu":"Bio | Manage | Match with Monomer Library...",description:"Matches molecules in a column with monomers from the selected library(s)"}),Cs(1,o.decorators.param({type:"column",options:{semType:"Molecule"}})),Cs(2,o.decorators.param({type:"string",options:{choices:["PEPTIDE","RNA","CHEM"],initialValue:"PEPTIDE",caption:"Polymer Type"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"matchWithMonomerLibrary",null),vs([o.decorators.func({outputs:[{type:"object",name:"monomerLib"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Object)],xs,"getBioLib",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Object)],xs,"getSeqHandler",null),vs([o.decorators.panel({name:"Bioinformatics | Get Region",description:"Creates a new column with sequences of the region between start and end",tags:["panel"]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"getRegionPanel",null),vs([o.decorators.panel({name:"Bioinformatics | Manage Monomer Libraries",meta:{"exclude-actions-panel":"true"},tags:["exclude-actions-panel"]}),Cs(0,o.decorators.param({name:"seqColumn",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Promise)],xs,"libraryPanel",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"GetRegionEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SplitToMonomersEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SequenceSpaceEditor",null),vs([o.decorators.editor({tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"SeqActivityCliffsEditor",null),vs([o.decorators.func({name:"customSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=custom",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",s.GridCellRenderer)],xs,"customSequenceCellRenderer",null),vs([o.decorators.func({name:"fastaSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=fasta",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"fastaSequenceCellRenderer",null),vs([o.decorators.func({name:"separatorSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=separator",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"separatorSequenceCellRenderer",null),vs([o.decorators.func({name:"bilnSequenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"sequence",columnTags:"quality=Macromolecule, units=biln",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ue)],xs,"bilnSequenceCellRenderer",null),vs([o.decorators.func({name:"refineNotationProviderForBiln",outputs:[{type:"bool",name:"result"}],tags:["notationRefiner"],meta:{role:"notationRefiner"}}),Cs(0,o.decorators.param({type:"column"})),Cs(1,o.decorators.param({type:"object"})),Cs(2,o.decorators.param({type:"string",options:{nullable:!0,optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,Object,Object]),ws("design:returntype",Boolean)],xs,"refineNotationProviderForBiln",null),vs([o.decorators.panel({name:"Bioinformatics | Sequence Renderer",tags:["panel"]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",s.Widget)],xs,"macroMolColumnPropertyPanel",null),vs([o.decorators.panel({name:"Composition analysis",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",s.Widget)],xs,"compositionAnalysisWidget",null),vs([o.decorators.panel({name:"Monomer",tags:["bio","panel"],meta:{domain:"bio"}}),Cs(0,o.decorators.param({options:{semType:"Monomer"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",s.Widget)],xs,"monomerInfoPanel",null),vs([o.decorators.func({name:"MacromoleculeDifferenceCellRenderer",tags:["cellRenderer"],meta:{cellType:"MacromoleculeDifference",columnTags:"quality=MacromoleculeDifference",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",ze)],xs,"macromoleculeDifferenceCellRenderer",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({options:{choices:["Local alignment","Global alignment"]}})),Cs(1,o.decorators.param({options:{choices:["AUTO","NUCLEOTIDES","BLOSUM45","BLOSUM50","BLOSUM62","BLOSUM80","BLOSUM90","PAM30","PAM70","PAM250","SCHNEIDER","TRANS"]}})),ws("design:type",Function),ws("design:paramtypes",[String,String,Number,String,String]),ws("design:returntype",void 0)],xs,"sequenceAlignment",null),vs([o.decorators.panel({name:"WebLogo",description:"WebLogo",tags:["viewer","panel"],meta:{icon:"files/icons/weblogo-viewer.svg",role:"viewer"},outputs:[{type:"viewer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"webLogoViewer",null),vs([o.decorators.panel({name:"VdRegions",description:"V-Domain regions viewer",tags:["viewer"],meta:{icon:"files/icons/vdregions-viewer.svg",role:"viewer"},outputs:[{type:"viewer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"vdRegionsViewer",null),vs([o.decorators.func({name:"getRegion",description:"Gets a new column with sequences of the region between start and end"}),Cs(0,o.decorators.param({type:"column"})),Cs(1,o.decorators.param({type:"string",options:{optional:!0}})),Cs(2,o.decorators.param({type:"string",options:{optional:!0}})),Cs(3,o.decorators.param({type:"string",options:{optional:!0,description:"Name of the column to be created"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,Object,Object,Object]),ws("design:returntype",s.Column)],xs,"getRegion",null),vs([o.decorators.func({name:"Get Region Top Menu",description:"Get sequences for a region specified from a Macromolecule","top-menu":"Bio | Calculate | Extract Region...",editor:"Bio:GetRegionEditor"}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequence column"}})),Cs(2,o.decorators.param({type:"string",options:{optional:!0,description:"Region start position name"}})),Cs(3,o.decorators.param({type:"string",options:{optional:!0,description:"Region end position name"}})),Cs(4,o.decorators.param({type:"string",options:{optional:!0,description:"Region column name"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Object,Object,Object]),ws("design:returntype",Promise)],xs,"getRegionTopMenu",null),vs([o.decorators.func({name:"Apply Numbering Scheme",description:"Assigns antibody numbering (IMGT/Kabat/Chothia/AHo) using AntPack","top-menu":"Bio | Annotate | Apply Numbering Scheme..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"applyNumberingScheme",null),vs([o.decorators.func({name:"Scan Liabilities",description:"Scans macromolecule sequences for deamidation, oxidation, and other liabilities","top-menu":"Bio | Annotate | Scan Liabilities..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"scanLiabilities",null),vs([o.decorators.func({name:"Manage Annotations",description:"View and manage sequence annotations on macromolecule columns","top-menu":"Bio | Annotate | Manage Annotations..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"manageAnnotations",null),vs([o.decorators.func({name:"Sequence Column Input",description:"Creates a new input for sequence columns with ability to extract a region"}),ws("design:type",Function),ws("design:paramtypes",[String,Object]),ws("design:returntype",Object)],xs,"sequenceColumnInput",null),vs([o.decorators.func({name:"Sequence Activity Cliffs",description:"Detects pairs of molecules with similar structure and significant difference in any given property","top-menu":"Bio | Analyze | Activity Cliffs...",editor:"Bio:SeqActivityCliffsEditor",outputs:[]}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({type:"string",options:{semType:"Macromolecule",description:"Input data table"}})),Cs(3,o.decorators.param({options:{initialValue:"80",description:"Similarity cutoff"}})),Cs(4,o.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Cs(5,o.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Cs(6,o.decorators.param({type:"func"})),Cs(7,o.decorators.param({type:"object",options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,s.Column,Number,String,String,s.Func,Object,Boolean]),ws("design:returntype",Promise)],xs,"activityCliffs",null),vs([o.decorators.func({name:"seqActivityCliffsInitFunction"}),Cs(0,o.decorators.param({type:"viewer"})),ws("design:type",Function),ws("design:paramtypes",[s.ScatterPlotViewer]),ws("design:returntype",Promise)],xs,"seqActivityCliffsInitFunction",null),vs([o.decorators.func({meta:{role:"transform"}}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"column",options:{type:"numerical"}})),Cs(3,o.decorators.param({options:{description:"Similarity cutoff",initialValue:"80"}})),Cs(4,o.decorators.param({type:"string"})),Cs(5,o.decorators.param({type:"string"})),Cs(6,o.decorators.param({options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,s.Column,Number,String,String,String,Boolean,Array]),ws("design:returntype",Promise)],xs,"seqActivityCliffsTransform",null),vs([o.decorators.func({name:"Encode Sequences",tags:["dim-red-preprocessing-function"],meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedDistanceFunctions:"Hamming,Levenshtein,Monomer chemical distance,Needlemann-Wunsch",role:"dim-red-preprocessing-function"},outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string"})),Cs(2,o.decorators.param({options:{initialValue:"1",caption:"Gap open penalty",optional:!0}})),Cs(3,o.decorators.param({options:{initialValue:"0.6",caption:"Gap extension penalty",optional:!0}})),Cs(4,o.decorators.param({options:{caption:"Fingerprint type",initialValue:"Morgan",choices:["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"],optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String,Number,Number,String]),ws("design:returntype",Promise)],xs,"macromoleculePreprocessingFunction",null),vs([o.decorators.func({name:"Helm Fingerprints",meta:{supportedSemTypes:"Macromolecule",supportedTypes:"string",supportedUnits:"helm",supportedDistanceFunctions:"Tanimoto,Asymmetric,Cosine,Sokal"},outputs:[{type:"object",name:"result"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string"})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String]),ws("design:returntype",Promise)],xs,"helmPreprocessingFunction",null),vs([o.decorators.func({name:"Sequence Space",description:"Creates 2D sequence space with projected sequences by pairwise distance","top-menu":"Bio | Analyze | Sequence Space...",editor:"Bio:SequenceSpaceEditor",outputs:[{type:"viewer",name:"result"}]}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"string",options:{choices:["UMAP","t-SNE"]}})),Cs(3,o.decorators.param({type:"string",options:{choices:["Hamming","Levenshtein","Monomer chemical distance"]}})),Cs(4,o.decorators.param({options:{initialValue:"true"}})),Cs(5,o.decorators.param({type:"func",options:{optional:!0}})),Cs(6,o.decorators.param({type:"object",options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0,initialValue:"true"}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String,String,Boolean,s.Func,Object,Boolean,Boolean]),ws("design:returntype",Promise)],xs,"sequenceSpaceTopMenu",null),vs([o.decorators.func({outputs:[{type:"viewer",name:"result"}],meta:{role:"transform"}}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(2,o.decorators.param({type:"string"})),Cs(3,o.decorators.param({type:"string"})),Cs(4,o.decorators.param({options:{initialValue:"true"}})),Cs(5,o.decorators.param({options:{optional:!0}})),Cs(6,o.decorators.param({options:{optional:!0}})),Cs(7,o.decorators.param({options:{optional:!0}})),Cs(8,o.decorators.param({options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String,String,Boolean,String,Boolean,Array,String]),ws("design:returntype",Promise)],xs,"sequenceSpaceTransform",null),vs([o.decorators.func({name:"Molecules to HELM","top-menu":"Bio | Transform | Molecules to HELM...",description:"Converts Peptide molecules to HELM notation by matching with monomer library"}),Cs(0,o.decorators.param({name:"table",options:{description:"Input data table"}})),Cs(1,o.decorators.param({name:"molecules",options:{semType:"Molecule",description:"Molecule column"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column]),ws("design:returntype",Promise)],xs,"moleculesToHelmTopMenu",null),vs([o.decorators.func({name:"Molecule to HELM Single",description:"Converts a single molecule to HELM notation without requiring a table or column",outputs:[{name:"result",type:"string",options:{semType:"Macromolecule",units:"helm"}}]}),Cs(0,o.decorators.param({name:"molecule",options:{semType:"Molecule",description:"Input molecule"}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"moleculeToHelmSingle",null),vs([o.decorators.func({name:"To Atomic Level",description:"Converts sequences to molblocks","top-menu":"Bio | Transform | To Atomic Level..."}),Cs(0,o.decorators.param({options:{description:"Input data table"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",caption:"Sequence"}})),Cs(2,o.decorators.param({options:{initialValue:"true",caption:"Non-linear",description:"Slower mode for cycling/branching HELM structures"}})),Cs(3,o.decorators.param({options:{initialValue:"false",caption:"Highlight monomers",description:"Highlight monomers' substructures of the molecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Boolean,Boolean]),ws("design:returntype",Promise)],xs,"toAtomicLevel",null),vs([o.decorators.func({name:"To Atomic Level...",meta:{action:"to atomic level"}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Promise)],xs,"toAtomicLevelAction",null),vs([o.decorators.panel({name:"Molecular Structure",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({name:"sequence",type:"semantic_value",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",Promise)],xs,"toAtomicLevelPanel",null),vs([o.decorators.func({name:"To Atomic Level Single sequence",description:"Converts a single sequence to molblock",outputs:[{name:"molfile",type:"string",options:{semType:"Molecule"}}]}),Cs(0,o.decorators.param({name:"sequence",type:"string",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"toAtomicLevelSingleSeq",null),vs([o.decorators.panel({name:"Molecular 3D Structure",tags:["bio","widgets","panel"],meta:{role:"widgets",domain:"bio"}}),Cs(0,o.decorators.param({type:"semantic_value",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.SemanticValue]),ws("design:returntype",Promise)],xs,"sequence3dStructureWidget",null),vs([o.decorators.panel({name:"MSA",description:"Performs multiple sequence alignment",tags:["bio","panel"],meta:{domain:"bio"},"top-menu":"Bio | Analyze | MSA..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"multipleSequenceAlignmentDialog",null),vs([o.decorators.func({name:"Multiple Sequence Alignment",description:"Multiple sequence alignment",meta:{domain:"bio"}}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"column"})),Cs(2,o.decorators.param({type:"object",options:{optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[Object,Object,Object]),ws("design:returntype",Promise)],xs,"alignSequences",null),vs([o.decorators.func({name:"PepSeA",description:"Aligns non-canonical peptide sequences using PepSeA Docker container (MAFFT)",meta:{role:"sequenceMSA"},outputs:[{name:"result",type:"column"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({type:"string",options:{choices:["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],initialValue:"mafft --auto"}})),Cs(2,o.decorators.param({type:"double",options:{initialValue:"1.53"}})),Cs(3,o.decorators.param({type:"double",options:{initialValue:"0"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column,String,Number,Number]),ws("design:returntype",Promise)],xs,"pepseaMsa",null),vs([o.decorators.func({name:"Composition Analysis",description:"Visualizes sequence composition on a WebLogo plot","top-menu":"Bio | Analyze | Composition",meta:{icon:"files/icons/composition-analysis.svg"},outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"compositionAnalysis",null),vs([o.decorators.fileHandler({name:"importFasta",tags:["fileHandler"],description:"Opens FASTA file",ext:"fasta, fna, ffn, faa, frn, fa, fst"}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Array)],xs,"importFasta",null),vs([o.decorators.fileHandler({name:"importBam",tags:["fileHandler"],description:"Opens Bam file",ext:"bam, bai"}),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Array)],xs,"importBam",null),vs([o.decorators.func({name:"convertDialog","top-menu":"Bio | Transform | Convert Sequence Notation..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"convertDialog",null),vs([o.decorators.func({name:"Convert Notation...",meta:{action:"Convert Notation..."}}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",void 0)],xs,"convertColumnAction",null),vs([o.decorators.func({name:"monomerCellRenderer",tags:["cellRenderer"],meta:{cellType:"Monomer",columnTags:"quality=Monomer",role:"cellRenderer"},outputs:[{type:"grid_cell_renderer",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",wi)],xs,"monomerCellRenderer",null),vs([o.decorators.func({name:"testDetectMacromolecule"}),Cs(0,o.decorators.param({options:{choices:["Demo:Files/","System:AppData/"]}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"testDetectMacromolecule",null),vs([o.decorators.func({name:"Split to Monomers","top-menu":"Bio | Transform | Split to Monomers...",editor:"Bio:SplitToMonomersEditor"}),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column]),ws("design:returntype",Promise)],xs,"splitToMonomersTopMenu",null),vs([o.decorators.func({name:"Bio: getHelmMonomers",outputs:[{name:"result",type:"object"}]}),Cs(0,o.decorators.param({type:"column",options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",Array)],xs,"getHelmMonomers",null),vs([o.decorators.func({name:"Sequence Similarity Search",meta:{icon:"files/icons/sequence-similarity-viewer.svg",role:"viewer"},tags:["viewer"],outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Ct)],xs,"similaritySearchViewer",null),vs([o.decorators.func({name:"similaritySearch",description:"Finds similar sequences","top-menu":"Bio | Search | Similarity Search",outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"similaritySearchTopMenu",null),vs([o.decorators.func({name:"Sequence Diversity Search",tags:["viewer"],meta:{icon:"files/icons/sequence-diversity-viewer.svg",role:"viewer"},outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",At)],xs,"diversitySearchViewer",null),vs([o.decorators.func({name:"diversitySearch",description:"Finds the most diverse sequences","top-menu":"Bio | Search | Diversity Search",outputs:[{name:"result",type:"viewer"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"diversitySearchTopMenu",null),vs([o.decorators.editor({name:"SearchSubsequenceEditor",tags:["editor"]}),ws("design:type",Function),ws("design:paramtypes",[s.FuncCall]),ws("design:returntype",void 0)],xs,"searchSubsequenceEditor",null),vs([o.decorators.func({name:"Subsequence Search","top-menu":"Bio | Search | Subsequence Search ...",editor:"Bio:SearchSubsequenceEditor"}),ws("design:type",Function),ws("design:paramtypes",[s.Column]),ws("design:returntype",void 0)],xs,"SubsequenceSearchTopMenu",null),vs([o.decorators.func({name:"Identity",description:"Adds a column with fraction of matching monomers","top-menu":"Bio | Calculate | Identity..."}),Cs(0,o.decorators.param({options:{description:"Table containing Macromolecule column"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Cs(2,o.decorators.param({options:{description:"Sequence,matching column format"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"sequenceIdentityScoring",null),vs([o.decorators.func({name:"Similarity",description:"Adds a column with similarity scores, calculated as sum of monomer fingerprint similarities","top-menu":"Bio | Calculate | Similarity..."}),Cs(0,o.decorators.param({options:{description:"Table containing Macromolecule column"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule",description:"Sequences to score"}})),Cs(2,o.decorators.param({options:{description:"Sequence,matching column format"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,String]),ws("design:returntype",Promise)],xs,"sequenceSimilarityScoring",null),vs([o.decorators.func({name:"Manage Monomer Libraries",description:"Manage HELM monomer libraries"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageMonomerLibraries",null),vs([o.decorators.func({name:"Manage Monomer Libraries View","top-menu":"Bio | Manage | Monomer Libraries"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageLibrariesView",null),vs([o.decorators.func({name:"manageMonomersView",description:"Edit and create monomers","top-menu":"Bio | Manage | Monomers"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"manageMonomersView",null),vs([o.decorators.app({tags:["app"],name:"Manage Monomer Libraries",browsePath:"Peptides",icon:"files/icons/monomers.png"}),Cs(0,o.decorators.param({options:{metaUrl:!0,optional:!0}})),ws("design:type",Function),ws("design:paramtypes",[String]),ws("design:returntype",Promise)],xs,"manageMonomerLibrariesView",null),vs([o.decorators.func({name:"Monomer Manager Tree Browser",meta:{role:"appTreeBrowser",app:"Manage Monomer Libraries"}}),ws("design:type",Function),ws("design:paramtypes",[s.TreeViewGroup]),ws("design:returntype",Promise)],xs,"manageMonomerLibrariesViewTreeBrowser",null),vs([o.decorators.app({tags:["app"],name:"Monomer Collections",browsePath:"Peptides",icon:"files/icons/monomers.png"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"monomerCollectionsApp",null),vs([o.decorators.fileExporter({description:"As FASTA..."}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"saveAsFasta",null),vs([o.decorators.func({name:"Bio Substructure Filter",description:"Substructure filter for macromolecules",tags:["filter"],meta:{semType:"Macromolecule",role:"filter"},outputs:[{type:"filter",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",jn._i)],xs,"bioSubstructureFilter",null),vs([o.decorators.func({name:"Bio Substructure Filter Test",description:"Substructure filter for Helm package tests",outputs:[{name:"result",type:"object"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",jn._i)],xs,"bioSubstructureFilterTest",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"webLogoLargeApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"webLogoAggApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getRegionApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getRegionHelmApp",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableSeparator",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableFasta",null),vs([o.decorators.func(),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",void 0)],xs,"longSeqTableHelm",null),vs([o.decorators.func(),Cs(0,o.decorators.param({type:"object"})),Cs(1,o.decorators.param({type:"object"})),ws("design:type",Function),ws("design:paramtypes",[s.Cell,s.Menu]),ws("design:returntype",void 0)],xs,"addCopyMenu",null),vs([o.decorators.demo({description:"Sequence similarity tracking and evaluation dataset diversity",demoPath:"Bioinformatics | Similarity, Diversity",path:"/apps/Tutorials/Demo/Bioinformatics/Similarity,%20Diversity"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioSimilarityDiversity",null),vs([o.decorators.demo({description:"Exploring sequence space of Macromolecules, comparison with hierarchical clustering results",demoPath:"Bioinformatics | Sequence Space",path:"/apps/Tutorials/Demo/Bioinformatics/Sequence%20Space",meta:{isDemoDashboard:"true"}}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioSequenceSpace",null),vs([o.decorators.demo({description:"Activity Cliffs analysis on Macromolecules data",demoPath:"Bioinformatics | Activity Cliffs",path:"/apps/Tutorials/Demo/Bioinformatics/Activity%20Cliffs"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioActivityCliffs",null),vs([o.decorators.demo({description:"Atomic level structure of Macromolecules",demoPath:"Bioinformatics | Atomic Level",path:"/apps/Tutorials/Demo/Bioinformatics/Atomic%20Level"}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"demoBioAtomicLevel",null),vs([o.decorators.func({name:"SDF to JSON Library"}),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame]),ws("design:returntype",Promise)],xs,"sdfToJsonLib",null),vs([o.decorators.func({friendlyName:"seq2atomic",description:"Converts a `Macromolecule` sequence to its atomic level `Molecule` representation",outputs:[{name:"molfile",type:"string",options:{semType:"Molecule"}}]}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String,Boolean]),ws("design:returntype",Promise)],xs,"seq2atomic",null),vs([o.decorators.func({name:"seqIdentity",friendlyName:"seqIdentity",description:"Gets identity to a reference sequence"}),Cs(0,o.decorators.param({options:{semType:"Macromolecule"}})),Cs(1,o.decorators.param({options:{semType:"Macromolecule"}})),ws("design:type",Function),ws("design:paramtypes",[String,String]),ws("design:returntype",Promise)],xs,"seqIdentity",null),vs([o.decorators.func(),Cs(2,o.decorators.param({options:{initialValue:"100"}})),ws("design:type",Function),ws("design:paramtypes",[s.FileInfo,String,Number]),ws("design:returntype",Promise)],xs,"detectMacromoleculeProbe",null),vs([o.decorators.func({outputs:[{type:"object",name:"result"}]}),ws("design:type",Function),ws("design:paramtypes",[]),ws("design:returntype",Promise)],xs,"getSeqHelper",null),vs([o.decorators.func(),Cs(1,o.decorators.param({type:"column"})),Cs(2,o.decorators.param({options:{initialValue:"true"}})),ws("design:type",Function),ws("design:paramtypes",[s.DataFrame,s.Column,Boolean]),ws("design:returntype",Promise)],xs,"getMolFromHelm",null);class Es{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}function Ms(){return As.logger.debug("Bio:test1() function"),{value:"value1"}}},4954(e,t,n){"use strict";n.d(t,{a7:()=>d,if:()=>p,BQ:()=>g,nI:()=>m});var i=n(4328),o=n(7389),r=n(6082),s=n(2003),a=n(439);async function l(e,t,n=!1,o){const s=t.getSeqHandler(e);let a;o??=new Map;const l=s.isHelm()?t.getSeqMonomers(e):Object.keys(s.stats.freq).filter(e=>""!==e);for(let e=0;e<l.length;e++)o.has(l[e])||o.set(l[e],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:e}),a=function(e,t,n=!1){const i=new Array(e.length);for(let o=0;o<e.length;o++){let r=0,s=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const c=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M V30 COUNTS ${c} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<c;e++){r=l.indexOf("\n",r)+1+31,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<u;e++){r=l.indexOf("\n",r)+1;const t=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(r+6,r+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",i[o]=a}return i}(a,o,n);else{a=new Array(e.length);for(let t=0;t<e.length;t++){const e=c(s.getSplitted(t),o,n);a[t]=e}}return r.Column.fromStrings("monomericMols",a)}function c(e,t,n=!1){let i="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";i+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,i+="M V30 BEGIN ATOM\n";for(let o=0;o<e.length;o++){const r=e.getCanonical(o);r!==a._S&&(i+=n?`M V30 ${o+1} R${t.get(r)} 0.000 0.000 0 0\n`:`M V30 ${o+1} At 0.000 0.000 0 0 MASS=${t.get(r)}\n`)}i+="M V30 END ATOM\n",i+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)i+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return i+="M V30 END BOND\n",i+="M V30 END CTAB\n",i+="M END",i}var u=n(4870);const h="substr_helm";class d{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,u.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then(()=>{setTimeout(()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))},100)})}updateInputs(){const e=this.units===s.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===s.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,u.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(s.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",()=>this.editHelmLinkAction(),void 0,{style:{position:"relative",left:"95px"}});const t=r.DataFrame.create(1);t.columns.addNewString(h).init(e=>""),t.col(h).semType=this.col.semType,t.col(h).meta.units=s.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(s.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK(async()=>{let e,n=this.units===s.Hi.HELM?t.get(h,0):this.substructureInput.value;this.units===s.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===s.Hi.HELM?await p(n,this.col,this.seqHelper):m(n,this.col),this.col.dataFrame.filter.and(e)}).show()}}function m(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,r=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(e,n):e,o=r.BitSet.create(t.length);for(let n=0;n<t.length;n++){const r=t.get(n);(r.match(i)||r===e)&&o.set(n,!0,!1)}return o}async function p(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await g(t,n,!0);const o=r.Column.string("helm",1).init(t=>e);o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=s.Hi.HELM;const a=await l(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:a.get(0),molBlockFailover:""})).get(0)}async function g(e,t,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await r.delay(10);const i=new Map,o=await l(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},3736(e,t,n){"use strict";n.d(t,{JG:()=>u,Ln:()=>r,Lz:()=>l,OW:()=>m,VT:()=>a,bq:()=>p,fh:()=>s,wi:()=>h,z5:()=>d});var i=n(2003),o=n(4517);function r(e){const t=e.getTag(i.gp.annotations);if(t)try{return JSON.parse(t)}catch{}const n=e.getTag(i.gp.regions);if(n)try{return JSON.parse(n).map((e,t)=>({id:`legacy-region-${t}`,name:e.name,description:e.description,start:e.start,end:e.end,visualType:o.ao.Region,category:o.eI.Structure,autoGenerated:!0}))}catch{}return[]}function s(e,t){e.setTag(i.gp.annotations,JSON.stringify(t));const n=t.filter(e=>e.category===o.eI.Structure);if(n.length>0){const t=n.filter(e=>null!=e.start&&null!=e.end).map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end}));e.setTag(i.gp.regions,JSON.stringify(t))}}function a(e){return`~${e}_annotations`}function l(e,t){const n=a(t.name);let o=e.columns.byName(n);return o||(o=e.columns.addNewString(n),t.setTag(i.gp.annotationColumnName,n)),o}const c=new WeakMap;function u(e,t){const n=c.get(e);if(n&&n.version===e.version&&void 0!==n.data[t])return n.data[t];const i=e.get(t);if(!i)return null;try{return JSON.parse(i)}catch{return null}}function h(e){const t=c.get(e);if(t&&t.version===e.version)return t.data;const n=new Array(e.length);for(let t=0;t<e.length;t++){const i=e.get(t);if(i)try{n[t]=JSON.parse(i)}catch{n[t]=null}else n[t]=null}return c.set(e,{version:e.version,data:n}),n}function d(e,t,n){e.set(t,n.length>0?JSON.stringify(n):"")}function m(e,t){t.setTag(i.gp.annotations,"");const n=a(t.name);e.columns.byName(n)&&e.columns.remove(n),t.setTag(i.gp.regions,"")}function p(e,t,n,i){let o=e;return n&&(o=o.filter(e=>null==e.endPositionIndex)),i&&(o=o.filter(e=>null!=e.endPositionIndex)),[...o,...t]}},966(e,t,n){"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(8012);function s(e,t,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,u]=a(e,t,l,n,o);return s&&!c&&i.shell.warning(u),c}function a(e,t,n,r=[],s=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(r.length>0&&!r.some(e=>o.toUpperCase()==e.toUpperCase()))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map(e=>`"${e}"`).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some(t=>e.toUpperCase()==t.toUpperCase())&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map(e=>`"${e}"`).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139(e,t,n){"use strict";var i,o,r,s,a;n.d(t,{J:()=>a,W_:()=>c,b9:()=>l,uF:()=>r}),function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(o||(o={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const l="3.3.1",c="sequenceMSA"},5433(e,t,n){"use strict";n.d(t,{C:()=>d});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(2738);let u=null,h=[];async function d(e,t){let n=e??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),d=s.notation;const m=o.divText("Current notation: "+d,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM,l.Hi.BILN],g=await c.$G.getProviderConstructors(),f=o.input.column("Column",{table:r.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),d=s.notation,d===l.Hi.HELM&&(v.value="/"),m.textContent="Current notation: "+d,b=p.filter(e=>e!==d),d===l.Hi.CUSTOM&&(b=[l.Hi.HELM]),d===l.Hi.HELM&&g.forEach(e=>{e.implementsFromHelm&&b.unshift(e.notationName)}),C=o.input.choice("Convert to",{value:b[0],items:b,onValueChanged:w}),w(),u?.clear(),void u?.add(o.div([m,f.root,C.root,v.root])))}),y=["-",".","/"];let b=p.filter(e=>e!==d);d===l.Hi.CUSTOM&&(b=[l.Hi.HELM]),d===l.Hi.HELM&&g.forEach(e=>{e.implementsFromHelm&&b.unshift(e.notationName)});const v=o.input.choice("Separator",{value:y[0],items:y}),w=()=>{C.value!==l.Hi.SEPARATOR?a()(v.root).hide():a()(v.root).show()};let C=o.input.choice("Convert to",{value:b[0],items:b,onValueChanged:w});w(),C.onChanged.subscribe(()=>{w()}),null==u&&(u=o.dialog("Convert Sequence Notation").add(o.div([m,f.root,C.root,v.root])).onOK(async()=>{const e=C.value,o=e===l.Hi.SEPARATOR?v.value:void 0;let s;!p.includes(e)&&g.find(t=>t.notationName===e)&&(s=g.find(t=>t.notationName===e)),await async function(e,t,n,o,s){if(s){const t=e.dataFrame.columns.getUnusedName(`${s.notationName}(${e.name})`),n=i.Column.string(t,e.length);return n.init(t=>{const n=e.get(t);try{return s.convertFromHelm(n,{})}catch(e){return console.error(`Error converting sequence at row ${t}: ${e instanceof Error?e.message:e}`),""}}),n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.CUSTOM,n.setTag("separator","-"),n.setTag("aligned","SEQ"),n.setTag("alphabet","UN"),n.setTag(".alphabetIsMultichar","true"),e.dataFrame.columns.add(n),await r.data.detectSemanticTypes(e.dataFrame),n}{const i=t.getSeqHandler(e).convert(n,o);e.dataFrame.columns.add(i);const s=await r.functions.call("Bio:detectMacromolecule",{col:i});return s&&(i.semType=s),await r.data.detectSemanticTypes(e.dataFrame),i}}(n,t,e,o,s)}).show({x:350,y:100}),h.push(u.onClose.subscribe(e=>{h.forEach(e=>{e.unsubscribe()}),h=[],u=null})))}},6956(e,t,n){"use strict";n.d(t,{m:()=>o,x:()=>i});const i="|",o="H"},2582(e,t,n){"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.x).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA|CHEM|BLOB)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA|CHEM|BLOB)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=e.indexOf("}$"),n=e.substring(0,t+1),i=e.indexOf("$",t+2),r=e.substring(t+2,i),a=n.split("}|");for(let e=0;e<a.length-1;e++)a[e]=a[e]+"}";this.simplePolymers=a.map(e=>new s(e)),this.connectionList=new o(r),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>t-e).find(t=>e>=t);if(null==n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},8604(e,t,n){"use strict";n.d(t,{G:()=>i});const i={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619(e,t,n){"use strict";n.d(t,{D:()=>T});var i=n(4328),o=n(6082),r=n(7389),s=n(2003),a=n(4025),l=n(608),c=n(966),u=n(4139),h=n(8012),d=n(5072),m=n.n(d),p=n(7825),g=n.n(p),f=n(7659),y=n.n(f),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=g(),E.insertStyleElement=C(),m()(x.A,E),x.A&&x.A.locals&&x.A.locals;class M{mode="kalign";currentFunc=null;currentFuncCall=null}async function T(e,t){return new Promise(async(n,d)=>{try{const m=e.col?.dataFrame??i.shell.t;if(!m)return void d(new l.Ap(r.divText("MSA requires a dataset with a macromolecule column.")));const p=e.col??m.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(!p)return void d(new l.Ap(r.divText("MSA requires a dataset with a macromolecule column.")));const g=new M;let f=p;const y=r.input.column("Sequence",{table:m,value:p,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return j.disabled=!0,await o.delay(0),void(y.value=f);f=e,j.disabled=!1,await B(e)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});y.setTooltip("Sequences column to use for alignment");const b=r.input.column("Clusters",{table:m,value:e.clustersCol});b.nullable=!0;const v=r.input.bool("Selected Rows Only",{value:!1}),w=r.input.float("Gap open",{value:e?.kalign?.gapOpen});w.setTooltip("Gap opening penalty at group-to-group alignment");const C=r.input.float("Gap extend",{value:e?.kalign?.gapExtend});C.setTooltip("Gap extension penalty to skip the alignment");const A=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});A.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const S=r.p(`Kalign version: ${u.b9}`,"kalign-version"),x=r.inputs([w,C,A]);x.hidden=!0;const E=r.button("Alignment parameters",()=>{x.hidden=!x.hidden,[w,C,A].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");E.classList.add("msa-params-button"),E.prepend(r.icons.settings(()=>null,"Settings"));const T=[x,E,S],L=o.Func.find({meta:{role:u.W_}});L.sort((e,t)=>{const n="true"===e.options.defaultAlignment?1:0;return("true"===t.options.defaultAlignment?1:0)-n});const _=r.input.choice("Engine",{value:L.length>0?L[0].friendlyName:"",items:L.map(e=>e.friendlyName)}),N=r.div("",{style:{fontSize:"12px",opacity:"0.7",marginBottom:"6px"}}),P=r.div(),R=r.button("Alignment parameters",()=>{P.hidden=!P.hidden},"Adjust engine-specific alignment parameters");R.classList.add("msa-params-button"),R.prepend(r.icons.settings(()=>null,"Settings"));const $=r.input.bool("Include HELM",{value:!0});$.setTooltip("Also add the aligned HELM column alongside the converted notation"),$.root.style.display="none";const O=[_.root,N,R,P,$.root];async function k(){P.innerHTML="",g.currentFuncCall=null;const e=_.value;if(g.currentFunc=L.find(t=>t.friendlyName===e)??null,N.textContent=g.currentFunc?.description??"",!g.currentFunc)return;g.currentFuncCall=g.currentFunc.prepare({});const t=await g.currentFuncCall.buildEditor(P);t.length>0&&"column"===t[0].inputType&&(t[0].root.style.display="none")}function H(e){g.mode=e;for(const t of T)t.style.display="kalign"===e?"":"none";for(const t of O)t.style.display="engine"===e?"":"none"}async function B(e){try{if(e.semType!==o.SEMTYPE.MACROMOLECULE)return;const n=(0,c.l)(e,e.name,t,[s.Hi.FASTA,s.Hi.SEPARATOR],[s.YI.DNA,s.YI.RNA,s.YI.PT])[0],r=(0,c.l)(e,e.name,t,[s.Hi.HELM],[])[0],l=(0,c.l)(e,e.name,t,[s.Hi.SEPARATOR,s.Hi.CUSTOM,s.Hi.BILN],[s.YI.UN])[0];if(n)H("kalign"),w.value=null,C.value=null,A.value=null;else if(r||l){if(0===L.length)return i.shell.warning("No MSA engines found for non-canonical sequences."),void H("kalign");H("engine"),await k();const t=e.temp?.[a.j.notationProvider],n=t?t.constructor:null,o=!0===n?.implementsFromHelm;$.root.style.display=o?"":"none"}else H("kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),h._package.logger.error(t)}}async function F(){const e=y.value;if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column must be of Macromolecule semantic type");return"kalign"===g.mode?D(e,m):G(e,m)}async function D(e,n){const i=n.columns.getUnusedName(`msa(${e.name})`),o=t.getSeqHandler(e),r=o.isFasta()?e:o.convert(s.Hi.FASTA);return(0,l.eE)(n,r,!1,i,b.value,w.value??void 0,C.value??void 0,A.value??void 0,v.value)}async function G(e,n){if(!g.currentFunc||!g.currentFuncCall)throw new Error("No MSA engine selected");const i=t.getSeqHandler(e);let r;r=i.isHelm()?e:(i.isSeparator()&&(i.alphabet,s.YI.UN),i.convert(s.Hi.HELM));const c=g.currentFunc,u=c.inputs[0].name,h={};for(let e=1;e<c.inputs.length;e++){const t=c.inputs[e].name;h[t]=g.currentFuncCall.inputs[t]}const d=await async function(e,t,n,i,r,a,c){const u=i.length;r??=o.Column.string("Clusters",u).init("0"),r.type!==o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING));const h=r.categories,d=r.getRawData(),m=new Array(h.length);if(a){const e=c.selection;if(0===e.trueCount)throw new Error("No selected rows in the table.");for(let t=-1;-1!==(t=e.findNext(t,!0));)(m[d[t]]??=[]).push(t)}else for(let e=0;e<u;e++)(m[d[e]]??=[]).push(e);(0,l.aZ)(m,h);const p=c.columns.getUnusedName(`msa(${i.name})`),g=new Array(u).fill("");let f=null;for(const r of m){if(!r||0===r.length)continue;const s=r.map(e=>i.get(e)),a=o.Column.fromStrings("seq",s);I(i,a),o.DataFrame.fromColumns([a]);const l=e.prepare({[t]:a,...n});await l.call();const c=l.getOutputParamValue();f=c;for(let e=0;e<r.length;e++)g[r[e]]=c.get(e)??""}const y=o.Column.fromStrings(p,g);if(f){y.meta.units=f.meta.units,y.semType=f.semType;for(const e of[s.gp.alphabet,s.gp.separator,s.gp.alphabetIsMultichar]){const t=f.getTag(e);t&&y.setTag(e,t)}}return y}(c,u,h,r,b.value,v.value,n),m=e.temp?.[a.j.notationProvider],p=m?m.constructor:null;if(p?.implementsFromHelm){const t=n.columns.getUnusedName(`msa(${e.name})`),i=o.Column.string(t,d.length);return i.init(e=>{const t=d.get(e);if(!t)return"";try{return p.convertFromHelm(t,{})}catch{return""}}),i.semType=o.SEMTYPE.MACROMOLECULE,i.meta.units=s.Hi.CUSTOM,i.setTag(s.gp.aligned,"SEQ.MSA"),i.setTag(s.gp.alphabet,s.YI.UN),$.value&&n.columns.add(d),i}return d}async function V(){if(!e.engine||"engine"!==g.mode)return;const t=L.find(t=>t.name===e.engine||t.friendlyName===e.engine);if(t&&(_.value=t.friendlyName,await k(),e.engineParams&&g.currentFuncCall))for(const[t,n]of Object.entries(e.engineParams))g.currentFuncCall.inputs[t]=n}_.onChanged.subscribe(()=>k());const q=r.dialog("MSA").add(y).add(b).add(_).add(N).add(R).add(P).add($).add(x).add(E).add(S).add(v).onOK(async()=>{const e=o.TaskBarProgressIndicator.create("Performing MSA...");try{const e=await F();m.columns.add(e),await i.data.detectSemanticTypes(m),e.meta.units!==s.Hi.HELM&&e.setTag(s.gp.aligned,"SEQ.MSA"),n(e)}catch(e){d(e)}finally{e.close()}}),j=q.getButton("OK");if(H("kalign"),y.fireChanged(),e.col){await B(e.col),await V();const U=o.TaskBarProgressIndicator.create("Performing MSA...");try{const W=await F();m.columns.add(W),await i.data.detectSemanticTypes(m),W.meta.units!==s.Hi.HELM&&W.setTag(s.gp.aligned,"SEQ.MSA"),n(W)}catch(z){d(z)}finally{U.close()}return}q.show()}catch(Y){d(Y)}})}function I(e,t){t.semType=e.semType,t.meta.units=e.meta.units;for(const n of[s.gp.alphabet,s.gp.separator,s.gp.alphabetIsMultichar]){const i=e.getTag(n);i&&t.setTag(n,i)}}},608(e,t,n){"use strict";n.d(t,{Ap:()=>H,aZ:()=>G,eE:()=>F});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),m=e=>"object"==typeof e&&null!==e||"function"==typeof e,p=new Map([["proxy",{canHandle:e=>m(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return g(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>m(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function g(e,t=self){t.addEventListener("message",function n(i){if(!i||!i.data)return;const{id:o,type:r,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const t=s.slice(0,-1).reduce((e,t)=>e[t],e),n=s.reduce((e,t)=>e[t],e);switch(r){case"GET":l=n;break;case"SET":t[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;g(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch(e=>({value:e,[d]:0})).then(e=>{const[i,s]=S(e);t.postMessage(Object.assign(Object.assign({},i),{id:o}),s),"RELEASE"===r&&(t.removeEventListener("message",n),f(t))})}),t.start&&t.start()}function f(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let i=!1;const o=new Proxy(n,{get(n,r){if(b(i),r===h)return()=>E(e,{type:"RELEASE",path:t.map(e=>e.toString())}).then(()=>{f(e),i=!0});if("then"===r){if(0===t.length)return{then:()=>o};const n=E(e,{type:"GET",path:t.map(e=>e.toString())}).then(x);return n.then.bind(n)}return v(e,[...t,r])},set(n,o,r){b(i);const[s,a]=S(r);return E(e,{type:"SET",path:[...t,o].map(e=>e.toString()),value:s},a).then(x)},apply(n,o,r){b(i);const s=t[t.length-1];if(s===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(e,t.slice(0,-1));const[a,l]=C(r);return E(e,{type:"APPLY",path:t.map(e=>e.toString()),argumentList:a},l).then(x)},construct(n,o){b(i);const[r,s]=C(o);return E(e,{type:"CONSTRUCT",path:t.map(e=>e.toString()),argumentList:r},s).then(x)}});return o}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map(e=>e[0]),w(t.map(e=>e[1]))]}const A=new WeakMap;function S(e){for(const[t,n]of p)if(n.canHandle(e)){const[i,o]=n.serialize(e);return[{type:"HANDLER",name:t,value:i},o]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return p.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise(i=>{const o=new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-");e.addEventListener("message",function t(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",t),i(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},t),n)})}const M="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",T=typeof window<"u"&&window.Blob&&new Blob([atob(M)],{type:"text/javascript;charset=utf-8"});function I(){const e=T&&(window.URL||window.webkitURL).createObjectURL(T);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+M)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const L={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class _{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},L,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new I;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map(([e,t])=>e)}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class R{constructor(e="categorial"){this.aa2num=P.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach(([e,t])=>this.num2aa[t]=e)}static _truncateSequence(e){let t=0,n=e.length;const i=["NH2","COOH"];if(e.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${i[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(i[1])){const t=i[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${i[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return R._dropDefises(R._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let i=0;i<t;++i){const t=e[i];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[i]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const i=e[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${e}'`),t+=this.num2aa[i]}return t}}var $=n(4139);const O="input.fa",k="result.fasta";class H extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function B(e){return e.reduce((e,t,n)=>e+`>sample${n+1}\n${t}\n`,"")}async function F(e,t,n=!1,i="",r=null,s,c,u,h){let d=t.toList();n&&(d=d.map(e=>R.clean(e).replace(/\-/g,"")));const m=t.length;r??=o.Column.string("Clusters",m).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const p=r.categories,g=r.getRawData(),f=new Array(p.length),y=new Array(p.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<m;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}G(y,p);const b=await new _(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),v=o.Column.string(i,m);for(let e=0;e<p.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=B(t);await b.fs.writeFile(O,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta -o ${k}${i}`);console.warn(o);const r=await b.cat(k);if(!r){const e=D(o,1);throw new Error(e)}const l=new a.m(r).sequencesArray,h=y[e];for(let e=0;e<l.length;++e)v.set(h[e],l[e])}const w=t.meta.units,C=t.getTag(l.gp.alphabet);return v.meta.units=w,v.setTag(l.gp.aligned,"SEQ.MSA"),v.setTag(l.gp.alphabet,C),v.semType=o.SEMTYPE.MACROMOLECULE,v}function D(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(e))&&(null==t||n.length<t);)n.push(o[1]);return n.join("\n")}function G(e,t){const n=e.map((e,t)=>[e,t]).filter(([e,t])=>1==e.length).map(([e,t])=>t);if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map(e=>{let o=t[e];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${e<n.length-1?", ":"."}`)}).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new H(e)}}},8152(e,t,n){"use strict";n.d(t,{Gf:()=>u});var i=n(4328),o=n(6082),r=n(2003),s=(n(608),n(4139)),a=n(8012);const l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"],c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}};async function u(e,t="mafft --auto",n=1.53,l=0){const u=await c.getDockerContainer(),d=e.length,m=[];for(let t=0;t<d;t++){const n=e.get(t);n&&m.push({ID:t.toString(),HELM:n})}const p=function(e,t){const n=new Array(t).fill(null);for(const t of e.Alignment)n[parseInt(t.ID)]=h(t);return n}(await async function(e,t,n,o,r,s){const l={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,l),d=window.performance.now();a._package.logger.debug(`Bio: requestAlignedObjects() ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok){if(m){const e=await h.json();if(e["pepsea-error"])throw new Error(`PepSeA error: ${e["pepsea-error"]}`);if(e["datagrok-error"])throw new Error(`Datagrok error: ${e["datagrok-error"]}`);throw new Error(h.statusText)}const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();return"pepsea-stderr"in p&&s?.warning(p["pepsea-stderr"]),p}(u.id,m,t,n,l),d);return function(e,t){const n=o.Column.fromStrings(e,t);return n.meta.units=r.Hi.SEPARATOR,n.setTag(r.gp.separator,s.J.SEPARATOR),n.setTag(r.gp.aligned,"SEQ.MSA"),n.setTag(r.gp.alphabet,r.YI.UN),n.setTag(r.gp.alphabetIsMultichar,"true"),n.semType=o.SEMTYPE.MACROMOLECULE,n}(e.dataFrame?.columns?.getUnusedName(`msa(${e.name})`)??`msa(${e.name})`,p)}function h(e){return Object.entries(e).filter(([e])=>!l.includes(e)).map(([,e])=>"-"!==e?e:"").join(s.J.SEPARATOR)}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(8012);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=u(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{n5:()=>C,oP:()=>L});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(8012);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,A=n(6307),S=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class x{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class E{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,S.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,A.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var T;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(T||(T={}));const I=new class{render=20};class L extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(T.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++L.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,I.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new E(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=T.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(T.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687(e,t,n){"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),v=n(8012);class w extends m.O{seqHelper;emptyProps=new m.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await o.delay(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await o.delay(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends m.O{emptyProps=new m.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new S(this.props.substructure,t,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use strict";const{normalizeIPv6:i,normalizeIPv4:o,removeDotSegments:r,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const o={};return i||(e=m(u(e,n),n),t=m(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(o.scheme=t.scheme,o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(o.userinfo=t.userinfo,o.host=t.host,o.port=t.port,o.path=r(t.path||""),o.query=t.query):(t.path?("/"===t.path.charAt(0)?o.path=r(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?o.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:o.path=t.path:o.path="/"+t.path,o.path=r(o.path)),o.query=t.query):(o.path=e.path,void 0!==t.query?o.query=t.query:o.query=e.query),o.userinfo=e.userinfo,o.host=e.host,o.port=e.port),o.scheme=e.scheme),o.fragment=t.fragment,o}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=r(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const h=Array.from({length:127},(e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function m(e,t){const n=Object.assign({},t),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const e=o(r.host);if(!1===e.isIPV4){const t=i(e.host);r.host=t.host.toLowerCase(),a=t.isIPV6}else r.host=e.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&r.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(e){r.error=r.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),e&&e.parse&&e.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const p={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(m(e,t),t):"object"==typeof e&&(e=m(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(m(e,i),m(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(m(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(m(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:m};e.exports=p,e.exports.default=p,e.exports.fastUri=p},343(e){"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function r(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const o=`${n}:${t.nid||e.nid}`,r=l[o];e.path=void 0,r&&(e=r.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),o=`${n}:${t.nid||i}`,r=l[o];r&&(e=r.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914(e){"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834(e,t,n){"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(o)||[],[n]=t;return n?{host:l(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function s(e,t=!1){let n="",o=!0;for(const t of e){if(void 0===i[t])return;"0"!==t&&!0===o&&(o=!1),o||(n+=t)}return t&&0===n.length&&(n="0"),n}function a(e){if(c(e,":")<2)return{host:e,isIPV6:!1};const t=function(e){let t=0;const n={error:!1,address:"",zone:""},i=[],o=[];let r=!1,a=!1,l=!1;function c(){if(o.length){if(!1===r){const e=s(o);if(void 0===e)return n.error=!0,!1;i.push(e)}o.length=0}return!0}for(let s=0;s<e.length;s++){const u=e[s];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!c())break;r=!0}else o.push(u);else{if(!0===a&&(l=!0),!c())break;if(t++,i.push(":"),t>7){n.error=!0;break}s-1>=0&&":"===e[s-1]&&(a=!0)}}return o.length&&(r?n.zone=o.join(""):l?i.push(o.join("")):i.push(s(o))),n.address=i.join(""),n}(e);if(t.error)return{host:e,isIPV6:!1};{let e=t.address,n=t.address;return t.zone&&(e+="%"+t.zone,n+="%25"+t.zone),{host:e,escapedHost:n,isIPV6:!0}}}function l(e,t){let n="",i=!0;const o=e.length;for(let r=0;r<o;r++){const s=e[r];"0"===s&&i?(r+1<=o&&e[r+1]===t||r+1===o)&&(n+=s,i=!1):(i=s===t,n+=s)}return n}function c(e,t){let n=0;for(let i=0;i<e.length;i++)e[i]===t&&n++;return n}const u=/^\.\.?\//u,h=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,m=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e){const t=[];if(void 0!==e.userinfo&&(t.push(e.userinfo),t.push("@")),void 0!==e.host){let n=unescape(e.host);const i=r(n);if(i.isIPV4)n=i.host;else{const t=a(i.host);n=!0===t.isIPV6?`[${t.escapedHost}]`:e.host}t.push(n)}return"number"!=typeof e.port&&"string"!=typeof e.port||(t.push(":"),t.push(String(e.port))),t.length?t.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(u))e=e.replace(u,"");else if(e.match(h))e=e.replace(h,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(m);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837(e){"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678(e){"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079(e){"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},i={};function o(e){var t=i[e];if(void 0!==t)return t.exports;var r=i[e]={id:e,loaded:!1,exports:{}};return n[e].call(r.exports,r,r.exports,o),r.loaded=!0,r.exports}o.m=n,o.amdO={},o.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return o.d(t,{a:t}),t},o.d=(e,t)=>{for(var n in t)o.o(t,n)&&!o.o(e,n)&&Object.defineProperty(e,n,{enumerable:!0,get:t[n]})},o.f={},o.e=e=>Promise.all(Object.keys(o.f).reduce((t,n)=>(o.f[n](e,t),t),[])),o.u=e=>e+".js",o.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),o.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),o.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="bio:",o.l=(n,i,r,s)=>{if(e[n])e[n].push(i);else{var a,l;if(void 0!==r)for(var c=document.getElementsByTagName("script"),u=0;u<c.length;u++){var h=c[u];if(h.getAttribute("src")==n||h.getAttribute("data-webpack")==t+r){a=h;break}}a||(l=!0,(a=document.createElement("script")).charset="utf-8",o.nc&&a.setAttribute("nonce",o.nc),a.setAttribute("data-webpack",t+r),a.src=n),e[n]=[i];var d=(t,i)=>{a.onerror=a.onload=null,clearTimeout(m);var o=e[n];if(delete e[n],a.parentNode&&a.parentNode.removeChild(a),o&&o.forEach(e=>e(i)),t)return t(i)},m=setTimeout(d.bind(null,void 0,{type:"timeout",target:a}),12e4);a.onerror=d.bind(null,a.onerror),a.onload=d.bind(null,a.onload),l&&document.head.appendChild(a)}},o.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;o.g.importScripts&&(e=o.g.location+"");var t=o.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var n=t.getElementsByTagName("script");if(n.length)for(var i=n.length-1;i>-1&&(!e||!/^http(s?):/.test(e));)e=n[i--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/^blob:/,"").replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),o.p=e})(),(()=>{o.b="undefined"!=typeof document&&document.baseURI||self.location.href;var e={242:0,529:0};o.f.j=(t,n)=>{var i=o.o(e,t)?e[t]:void 0;if(0!==i)if(i)n.push(i[2]);else{var r=new Promise((n,o)=>i=e[t]=[n,o]);n.push(i[2]=r);var s=o.p+o.u(t),a=new Error;o.l(s,n=>{if(o.o(e,t)&&(0!==(i=e[t])&&(e[t]=void 0),i)){var r=n&&("load"===n.type?"missing":n.type),s=n&&n.target&&n.target.src;a.message="Loading chunk "+t+" failed.\n("+r+": "+s+")",a.name="ChunkLoadError",a.type=r,a.request=s,i[1](a)}},"chunk-"+t,t)}};var t=(t,n)=>{var i,r,[s,a,l]=n,c=0;if(s.some(t=>0!==e[t])){for(i in a)o.o(a,i)&&(o.m[i]=a[i]);l&&l(o)}for(t&&t(n);c<s.length;c++)r=s[c],o.o(e,r)&&e[r]&&e[r][0](),e[r]=0},n=self.webpackChunkbio=self.webpackChunkbio||[];n.forEach(t.bind(null,0)),n.push=t.bind(null,n.push.bind(n))})(),o.nc=void 0;var r=o(8012);bio=r})();
8
8
  //# sourceMappingURL=package.js.map