@datagrok/bio 2.26.7 → 2.26.8

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Files changed (11) hide show
  1. package/dist/package-test.js +1 -1
  2. package/dist/package-test.js.map +1 -1
  3. package/dist/package.js +1 -1
  4. package/dist/package.js.map +1 -1
  5. package/package.json +1 -1
  6. package/src/package.ts +1 -1
  7. package/src/utils/cell-renderer.ts +2 -2
  8. package/src/utils/monomer-cell-renderer.ts +1 -1
  9. package/src/widgets/monomer-info-widget.ts +90 -50
  10. package/test-console-output-1.log +567 -651
  11. package/test-record-1.mp4 +0 -0
package/dist/package.js CHANGED
@@ -4,5 +4,5 @@ var bio;(()=>{var e,t,n={8924(e,t,n){"use strict";var i=n(7362);class o extends
4
4
  || ${a} === "boolean" || ${o} === null`).assign(l,s._`[${o}]`)}}i.else(),p(e),i.endIf(),i.if(s._`${l} !== undefined`,()=>{i.assign(o,l),function({gen:e,parentData:t,parentDataProperty:n},i){e.if(s._`${t} !== undefined`,()=>e.assign(s._`${t}[${n}]`,i))}(e,l)})}(e,t,a):p(e)})}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,i=l.Correct){const o=i===l.Correct?s.operators.EQ:s.operators.NEQ;let r;switch(e){case"null":return s._`${t} ${o} null`;case"array":r=s._`Array.isArray(${t})`;break;case"object":r=s._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":r=a(s._`!(${t} % 1) && !isNaN(${t})`);break;case"number":r=a();break;default:return s._`typeof ${t} ${o} ${e}`}return i===l.Correct?r:(0,s.not)(r);function a(e=s.nil){return(0,s.and)(s._`typeof ${t} == "number"`,e,n?s._`isFinite(${t})`:s.nil)}}function d(e,t,n,i){if(1===e.length)return h(e[0],t,n,i);let o;const r=(0,a.toHash)(e);if(r.array&&r.object){const e=s._`typeof ${t} != "object"`;o=r.null?e:s._`!${t} || ${e}`,delete r.null,delete r.array,delete r.object}else o=s.nil;r.number&&delete r.integer;for(const e in r)o=(0,s.and)(o,h(e,t,n,i));return o}t.checkDataType=h,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?s._`{type: ${e}}`:s._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:n,schema:i}=e,o=(0,a.schemaRefOrVal)(e,i,"type");return{gen:t,keyword:"type",data:n,schema:i.type,schemaCode:o,schemaValue:o,parentSchema:i,params:{},it:e}}(e);(0,r.reportError)(t,m)}t.reportTypeError=p},7870(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const i=n(9029),o=n(4227);function r(e,t,n){const{gen:r,compositeRule:s,data:a,opts:l}=e;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(t)}`;if(s)return void(0,o.checkStrictMode)(e,`default is ignored for: ${c}`);let u=i._`${c} === 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n=u.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function A(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:p}=e,{RULES:g}=p;function f(m){(0,r.shouldUseGroup)(a,m)&&(m.type?(o.if((0,s.checkDataType)(m.type,l,d.strictNumbers)),S(e,m),1===t.length&&t[0]===m.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):S(e,m),c||o.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(a,g)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach(t=>{x(e.dataTypes,t)||E(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)}),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&E(e,"use 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(strictTypes)`,(0,m.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:i}=e;g(e,()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,m.checkStrictMode)(e,"default is ignored in the schema root")}(e),i.let(h.default.vErrors,null),i.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`)),t.if(u._`${e.evaluated}.dynamicItems`,()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:i,ValidationError:o,opts:r}=e;n.$async?t.if(u._`${h.default.errors} === 0`,()=>t.return(h.default.data),()=>t.throw(u._`new 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console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const i=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,e,"NOT SUPPORTED"),A.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=T.call(this),e.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&M.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),x.call(this),e.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let i=m;"id"===n&&(i={...m},i.id=i.$id,delete i.$id),t&&e&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const i=n(t);return"$async"in 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r=t.name("valid");n.forEach((t,n)=>{if((0,i.alwaysValidSchema)(o,t))return;const s=e.subschema({keyword:"allOf",schemaProp:n},r);e.ok(r),e.mergeEvaluated(s)})}};t.default=o},6505(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=i},2661(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?i.str`must contain at least ${e} valid item(s)`:i.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?i._`{minContains: ${e}}`:i._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:r,data:s,it:a}=e;let 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5
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i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),m=i.type;!0!==(r=d.next()).done;){var p=!1;if(s=r.value,"undirected"!==m)for(a in l=s.out){c=l[a];do{if(u=c.target,p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==m)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!p&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new G('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new G("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new G('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new G("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new G("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new G("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new q("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var m=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,m&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,m&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Ee(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new G("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new q("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;p||(p=Se(e,r,{}),v=!0,r===s&&(g=p,w=!0)),g||(g=Se(e,s,{}),w=!0),d=new z(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new G("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new G('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new G("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?U:W;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new G("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new q("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new G('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new q('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new G('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new G('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new G("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new G("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new G("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new G("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new G("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new G("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new G("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new G("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new G("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new G("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new G("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new G("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new G("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new G("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new G("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new G("Graph.import: invalid edges. 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}var R=n(9713),$=n(6295);const O=e=>null==e;function k(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class H{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,g=Number.MIN_VALUE;for(let 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l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let m=0;const p=(a+1)/n;for(let e=0;e<o;e++)r[e]<p&&(l[m]=h[e],c[m]=d[e],u[m]=r[e],m++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)k(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)k(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,D=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class G{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new D.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,t),r=this.getPointOnDistance(S,x,w,C,n,t);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new D.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var q,j=n(3629);async function U(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,j.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(q||(q={}));const W={[q.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[q.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var z;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(z||(z={}));const Y={[z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[z.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},K={[z.HAMMING]:e=>Math.ceil(e/30),[z.EUCLIDEAN]:e=>Math.ceil(e/30),[z.MANHATTAN]:e=>Math.ceil(e/30),[z.TANIMOTO]:e=>Math.ceil(e/30),[z.SOKAL]:e=>Math.ceil(e/30),[z.COSINE]:e=>Math.ceil(e/30),[z.ASYMMETRIC]:e=>Math.ceil(e/30),[z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[z.Difference]:e=>1,[z.OneHot]:e=>Math.ceil(e/40),[z.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([z.HAMMING,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.MONOMER_CHEMICAL_DISTANCE,z.OneHot]),UINT32ARRAY:new Set([z.HAMMING,z.EUCLIDEAN,z.MANHATTAN,z.MONOMER_CHEMICAL_DISTANCE,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.TANIMOTO,z.COSINE,z.VECTOR_COSINE,z.SOKAL,z.ASYMMETRIC,z.OneHot,z.Difference]),INT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.OneHot,z.Difference,z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference,z.VECTOR_COSINE]),NUMBER:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference]),BITARRAY:new Set([z.TANIMOTO,z.COSINE,z.SOKAL,z.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device 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instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=K[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===z.NEEDLEMAN_WUNSCH||t===z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/f),T=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${J(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),_=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(A/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?A-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);_[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),H=h.reduce((e,t)=>e+t.suppInfoSize,0),B=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let D=F;const G=15&F;0!==G&&(D+=16-G);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let U=0;new Uint32Array(j,U,f).set(_),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(L),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(N),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f).set(P),U+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g.length).set(g),U+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const W=H*Uint32Array.BYTES_PER_ELEMENT;let Y=W;const X=15&W;0!==X&&(Y+=16-X),Y=Math.max(Y,16);const Q=s.createBuffer({label:"supp info buffer",size:Y,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,B);o+=B*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),Q.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function J(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${Y[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${W[i](e.length)}\n }\n \n `}var Q=n(1991),ee=n.n(Q);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,n,i,a,l,c,u,h,d,m,p,g,f,y,b){te++;const v=c/100;let w,C=!1;const A=o.shell.tv?.dataFrame===t?o.shell.tv:o.shell.getTableView(t.name);let S=null;if(h.useWebGPU)try{S=await X([i.entries],v,[u],q.MANHATTAN,[1],[i.options??{}])}catch(e){console.error(e)}S||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),S=await(new B).calc(i.entries,u,v,i.options));const x=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,a=s.BitSet.create(t.length);return e.distance.forEach((t,n)=>{a.set(e.i[n],!0),a.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:a}}(S,a),E=`sali_${l[0].substring(l[0].lastIndexOf("_"))}`;if(!t.columns.names().includes(E)){const i=function(e,t,n,i,o,r,a){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(a.get(i[e])>a.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return s.Column.fromList("double",t,l)}(n.length,E,x.saliVals,x.n1,x.n2,0,a);t.columns.add(i),e.setOptions({size:i.name})}const M=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(x.saliVals),T=.8/(M.max-M.min),I=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(t,x,n,a,d,m,M,T);I.lines.skipMultiLineCalculation=!0,I.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const _=new G(e,l[0],l[1],I.lines,F.none);let L=null;const N=r.button(`${I.linesDf.rowCount} cliffs`,()=>{if(!L?.dataFrame){L=(()=>{const e=f?f(I.linesDf,se).sort([oe],[!1]):I.linesDf.plot.grid().sort([oe],[!1]);return e.col(re)&&(e.col(re).visible=!1),t.temp[".cliffsDfGrid"]=L,e})();const e=ee()(A.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);b&&!e&&A.addViewer(L),A.dockManager.dock(L,"down",void 0,"Activity cliffs",y??.2)}});N.classList.add("scatter_plot_link","cliffs_grid");const P=r.input.toggle("Show only cliffs",{value:!1,onValueChanged:n=>{n?(e.dataFrame.setTag(ae,l[0]),t.filter.and(x.cliffsBitSet),ie.next(l[0])):(e.dataFrame.setTag(ae,""),t.filter.setAll(!0),ie.next(""))}});e.root.prepend(r.divH([N,P.root],"cliffs_div")),ie.subscribe(e=>{P.enabled=""===e||e===l[0]}),t.onRowsFiltering.subscribe(()=>{P.value&&t.filter.and(x.cliffsBitSet)});const $=o.events.onViewerClosed.subscribe(t=>{t.args.viewer===e&&(L&&A.dockManager.close(L.root),$.unsubscribe(),A.subs=A.subs.filter(e=>e!==$))});A.subs.push($),I.linesDf.onCurrentCellChanged.subscribe(()=>{for(let e=0;e<I.linesDf.rowCount;e++)I.lines.widths[e]=e===I.linesDf.currentRowIdx?3:1;_.linesToRender=I.lines;const i=I.linesDf.currentCol&&I.linesDf.currentCol.name===se[1]?I.lines.to:I.lines.from,s=-1!==I.linesDf.currentRowIdx?I.linesDf.currentRowIdx:null;if(e.dataFrame.currentRowIdx=s?i[s]:-1,null!==s){const i=I.linesDf.currentRowIdx;_.currentLineId=i;const{zoomLeft:c,zoomRight:u,zoomTop:h,zoomBottom:d}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<o?n:o)+s/2-h/2,p=(i>r?i:r)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(e.viewport.width,e.viewport.height,e.dataFrame.get(l[0],I.lines.from[i]),e.dataFrame.get(l[1],I.lines.from[i]),e.dataFrame.get(l[0],I.lines.to[i]),e.dataFrame.get(l[1],I.lines.to[i]));e.zoom(c,h,u,d),P.value?t.filter.and(x.cliffsBitSet):!0===P.enabled&&t.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,s,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:s,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout(()=>{o.shell.o=t.root},500)}(t,w,I.lines.from[s],I.lines.to[s],s,n,a,I.linesDf.get(oe,s),g);const i=e.dataFrame.getSortedOrder(A.grid.sortByColumns,A.grid.sortTypes);A.grid.scrollToCell(n.name,i.indexOf(e.dataFrame.currentRowIdx))},1e3)}}),I.linesDf.onSelectionChanged.subscribe(e=>{setTimeout(()=>(()=>{const e=s.BitSet.create(t.rowCount);for(let t=0;t<I.linesDf.rowCount;t++){const n=I.linesDf.selection.get(t);n&&(e.set(I.lines.from[t],!0),e.set(I.lines.to[t],!0)),I.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),_.linesToRender=I.lines})(),100)}),t.onSelectionChanged.subscribe(e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(!C&&L?.dataFrame?(e=>{e.selection.setAll(!1);for(let e=0;e<I.lines.colors.length;e++)I.lines.colors[e]="0,128,0";_.linesToRender=I.lines})(L.dataFrame):C=!1)}),_.lineClicked.subscribe(e=>{if(C=!0,_.currentLineId=e.id,-1!==e.id){const n=I.linesDf.selection.clone();setTimeout(()=>{if(e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),I.linesDf.selection.copyFrom(n)):(I.linesDf.currentRowIdx!==e.id&&(I.linesDf.currentRowIdx=e.id,t.currentRowIdx=I.lines.from[e.id]),I.linesDf.selection.copyFrom(n)),L?.dataFrame){const t=I.linesDf.getSortedOrder(L.sortByColumns,L.sortTypes);L.scrollToCell(se[0],t.indexOf(e.id))}},500)}}),_.lineHover.pipe((0,R.debounceTime)(500)).subscribe(e=>{-1!==e.id&&-1===t.mouseOverRowIdx&&r.tooltip.show(p({lineId:e.id,points:[I.lines.from[e.id],I.lines.to[e.id]],df:t,seqCol:n,activityCol:a}),e.x,e.y)}),e.addProperty("similarityLimit","double",v),w=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}()}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151),me=n(4025),pe=n(439);function ge(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getOriginal(o);(n(o)||i(o)).set(e,r,!1)}}const c=e.temp[me.j.notationProvider]??null,u=c?.monomerCanonicalizerFuncName;if(u)for(const e of o)e.setTag(pe.jz,u);return a}var fe,ye=n(4971);async function be(e){const t=(await(0,ye.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var ve=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ce extends P{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[L]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,Se,xe;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Me(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Te(e,t,i,l,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==l.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=s.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=g.embedColsNames??Ee(e);function x(n,o,l){let c=null,u=null;e.columns.names().includes(S[0])?(c=e.columns.byName(S[0]),u=e.columns.byName(S[1])):(c=e.columns.add(s.Column.float(S[0],e.rowCount)),u=e.columns.add(s.Column.float(S[1],e.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}))),g[a.YP]&&(A?.root&&r.setUpdateIndicator(A.root,!1),c.init(e=>l[0]?l[0][e]:void 0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function E(){e.columns.add(s.Column.float(S[0],e.rowCount)),e.columns.add(s.Column.float(S[1],e.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}),r.setUpdateIndicator(A.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await U(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:x))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await E();if(m&&M){const T=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),_=g.clusterColName??e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(_).init(e=>I[e].toString()),A&&(A.props.colorColumnName=_)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(M){const N=e.columns.byName(S[0]),P=e.columns.byName(S[1]);if(N.init(e=>M[0][e]),P.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return r.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&r.setUpdateIndicator(A.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Se||(Se={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(xe||(xe={})),Object.prototype.toString;var Ie=n(6873),_e=n(4356),Le=n(6717),Ne=n(4870),Pe=n(3856),Re=n(6882),$e=n(7278),Oe=n(5553),ke=n(6642),He=n(3599),Be=n(673),Fe=n(8312);class De extends ke.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,ys.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,Fe.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ge=n(4139);const Ve=ue.zS;function qe(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class je extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=ys.seqHelper}getRendererBack(e){const[t,n,i]=(0,ke.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Oe.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,ke.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(ys.properties?ys.properties.maxMonomerLength:4)??50;if(Pe.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Pe.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new Re.Jy(a,l,ys.logger,d,()=>{const{font:e,fontWidth:t}=Re.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:Ve}}),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class Ue extends De{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator];let h=this.tableCol.meta.units;i=(0,Re.U0)(l,e,t,i,a);const[d,m]=c.split("#");h!==ue.Hi.CUSTOM||this.tableCol.temp[me.j.notationProvider]||(h=ue.Hi.SEPARATOR);const p=this.tableCol.temp[me.j.notationProvider]?.separatorSplitter??this.tableCol.temp[me.j.notationProvider]?.splitter??(0,$e.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),v=this.tableCol.getTag(ue.gp.alphabet);ze(e,t,n,i,o,y,b,v===ue.YI.RNA||v===ue.YI.DNA?He.o.NUCLEOTIDE:He.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new Ue(t,n)),o}}class We extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ge.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){Ue.getOrCreate(r).render(e,t,n,i,o,r,s)}}function ze(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(pe.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(qe(r).join("")),d=e.measureText(qe(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Re.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Re.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Pe.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Pe.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ye(n,c,d,r,g,h,o))}else p=(0,Pe.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ye(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(qe([e]).join("")).width,u=l.measureText(qe([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Pe.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Pe.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Ke,Ze=n(8070),Xe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Ke||(Ke={}));const Je=new class{constructor(){this.regionTypes=[Ke.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Xe.fH.Entropy,this.filterSource=Xe.Fo.filterSource}};var Qe=n(7602),et=n(250);const tt=Ke;var nt,it;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(nt||(nt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(it||(it={}));const ot=Je;class rt extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(it.skipEmptyPositions,ot.skipEmptyPositions,{category:nt.DATA}),this.regionTypes=this.stringList(it.regionTypes,ot.regionTypes,{category:nt.DATA,choices:Object.values(tt).filter(e=>e!=tt.Unknown)}),this.chains=this.stringList(it.chains,ot.chains,{category:nt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(it.fitWidth,ot.fitWidth,{category:nt.LAYOUT}),this.positionWidth=this.float(it.positionWidth,ot.positionWidth,{category:nt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(it.positionHeight,ot.positionHeight,{category:nt.LAYOUT,choices:Object.keys(Xe.fH)}),this.filterSource=this.string(it.filterSource,ot.filterSource,{category:nt.BEHAVIOR,choices:Object.values(Xe.lT)}),this.viewSyncer=new Qe.g(ys.logger)}static viewerCounter=-1;viewerId=++rt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case it.regionTypes:case it.chains:this.setData(this.regions)}switch(e.name){case it.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case it.fitWidth:case it.positionWidth:this.calcSize();break;case it.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionHeight]:this.positionHeight});this.calcSize();break;case it.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;ys.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){ys.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){ys.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);r&&i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Xe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),ys.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){ys.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[et.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(it.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[et.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Ze.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class st{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class at{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new at(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ct(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=ys.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,ye.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await be(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await be(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ut=n(4954);function ht(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function dt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=ys.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=pt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function pt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=ys.monomerLib;return ze(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function gt(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function ft(e,t){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class yt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class bt extends yt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const vt={gapPenalty:1,matchScore:1,gapSymbol:pe.b9[pe.Hi.FASTA],localAlignment:!1};class wt extends bt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Ne.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Ne.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ct(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new B).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...vt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new $e.Mu(d,i.gapSymbol),seq2Splitted:new $e.Mu(m,i.gapSymbol)}}(c,u),d=pt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class Ct extends bt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Ne.Kd)(i,t.name,450,30),(0,Ne.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ct(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new H(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var At=n(5433),St=n(3736),xt=n(4517);class Et{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Mt={A:new D.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new D.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new D.A(new 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Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new D.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new D.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new D.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new D.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new D.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new D.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},Tt={RNA:{A:new D.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new D.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new D.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new D.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new D.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:Mt};async function It(e,t,n=0){if(!Object.keys(Tt).includes(t))return null;const i=await async function(e){const t=s.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new D.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Tt[t])return null;const o=Tt[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var _t;!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(_t||(_t={}));class Lt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Nt extends Lt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends Nt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(_t.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(_t.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(_t.TYPE)&&-1!==e.indexOf(_t.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,_t.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<_t.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,_t.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,_t.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+_t.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=_t.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt extends Nt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Pt(e);if($t.isMolfileV3K(e))return new Rt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return Rt.isValidMolfile(e)}}var Ot=n(6197),kt=n(9124),Ht=n(3527);class Bt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Bt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ft extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Dt extends Bt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Gt extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Vt extends Bt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class qt extends Bt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class jt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new qt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new jt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Ut={[He.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[He.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[He.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[He.o.CHEM]:{R:"#eeeeee"},[He.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Wt=/.*\|\$.*R.*\$\|/,zt=/\[R(\d+)\]/,Yt=/\[R(\d+)\]/g,Kt=/\[\*:(\d+)\]/g;function Zt(e,t){const n=Array.from(e.matchAll(Yt)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=kn(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){ys.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const Xt=/[\w()]+/,Jt=RegExp(String.raw`\(${Xt}(,${Xt})+\)`),Qt=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},en=new Ht.Mi([255,255,255]),tn=new Ht.Mi([0,0,0]),nn=.7*(0,j.wQ)(en);class on{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==pe._S||t===pe.b9[pe.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(Wt.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return Zt(a,t)}let n=e;const i=Array.from(e.matchAll(Kt));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(zt.test(n))return Zt(n,t)}catch(t){ys.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Ft((0,$e.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,kt.fA)(e,t),o=(0,Ot.Y)(n);let r=this.getMonomer(o,i);if(r&&n==He.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==He.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===pe._S||"*"==i?s=r.wem=new Dt(n):n===He.o.NUCLEOTIDE&&"N"===i||n===He.o.AA&&"X"===i||(He.o.CHEM,0)||Jt.test(i)?s=r.wem=new Gt(n,i):r.lib||(s=r.wem=new Vt(n,i,this.isEmpty)),s||(s=r.wem=jt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Ot.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?Qt(s.molfile):s.smiles?r.divV([Qt(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=pe._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Ht.Mi([...o.map(e=>e+1)]),a=(0,j.KE)(r,en)/((0,j.wQ)(r)*(0,j.wQ)(en)),l=i(n.backgroundcolor),c=new Ht.Mi([...l.map(e=>e+.01)]);let u;u=(0,j.KE)(c,en)/((0,j.wQ)(c)*(0,j.wQ)(en))<a?l:o;let h=new Ht.Mi(u);const d=(0,j.wQ)(h);return d>nn&&(h=(0,j.dC)(tn,h,nn/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Ot.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){ys.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Ut[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var rn=n(5488),sn={};sn.styleTagTransform=C(),sn.setAttributes=y(),sn.insert=g().bind(null,"head"),sn.domAPI=m(),sn.insertStyleElement=v(),h()(rn.A,sn),rn.A&&rn.A.locals&&rn.A.locals;class an extends on{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,Ot.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,_e.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new ln(e,`override: ${++an.overrideCounter}, ${t}`,this)}}class ln extends on{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var cn=n(8604),un=n(7433),hn=n.n(un),dn=n(1913),mn=n.n(dn);class pn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(hn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});mn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class gn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=ye.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText(gn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new pn(i);gn._instance=new gn(r,e,t),gn._instance.refreshLists()}return gn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new ye.lH(n,i,o,r,s)});t.push(new ye.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}const fn="System:AppData/Bio/monomer-collections/";class yn{logger;_monomerLib=new an({},"MAIN");_monomerSets=new ye.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await s.delay(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await gn.getInstance(this,ys.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++yn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return yn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,_e.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new an(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,_e.E)(cn.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new an(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===ye.ic);if(!t)throw new Error(`Provider '${ye.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new an(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,ye.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async listMonomerCollections(){return(await o.dapi.files.list(fn)).filter(e=>"json"===e.extension||e.name.endsWith(".json")).map(e=>e.name)}async deleteMonomerCollection(e){e.endsWith(".json")||(e+=".json"),await o.dapi.files.exists(fn+e)&&await o.dapi.files.delete(fn+e)}async readMonomerCollection(e){e.endsWith(".json")||(e+=".json");const t=await o.dapi.files.readAsText(fn+e);return JSON.parse(t)}async addOrUpdateMonomerCollection(e,t,n,i){e.endsWith(".json")||(e+=".json");const r=JSON.stringify({description:n,tags:i,monomerSymbols:t,updatedBy:s.User.current().login,updatedOn:(new Date).toISOString()},null,2);await o.dapi.files.writeAsText(fn+e,r)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new yn(ys.logger))()),e}}var bn=n(857),vn={};vn.styleTagTransform=C(),vn.setAttributes=y(),vn.insert=g().bind(null,"head"),vn.domAPI=m(),vn.insertStyleElement=v(),h()(bn.A,vn),bn.A&&bn.A.locals&&bn.A.locals;const wn=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];function Cn(e,t,n){let i=t[e]??n[e];if(i&&i.length>0)return i;const r=Hn(e,wn);if(r!==e){const e=o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles);if(i=t[e]??n[e],i&&i.length>0)return i}return[]}function An(e){const t=new Set;return e.filter(e=>!t.has(e.symbol)&&(t.add(e.symbol),!0))}function Sn(e,t){const n=new Set;for(const i of e){const e=t[i.symbol];if(e&&e.length>0)for(const t of e){const e=t?.lib?.source;e&&n.add(e)}else i.source&&n.add(i.source)}return Array.from(n).join(", ")}var xn;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(xn||(xn={}));const En={[xn.MONOMER]:s.COLUMN_TYPE.STRING,[xn.SYMBOL]:s.COLUMN_TYPE.STRING,[xn.NAME]:s.COLUMN_TYPE.STRING,[xn.R_GROUPS]:s.COLUMN_TYPE.STRING,[xn.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[xn.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[xn.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[xn.AUTHOR]:s.COLUMN_TYPE.STRING,[xn.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[xn.ID]:s.COLUMN_TYPE.INT,[xn.META]:s.COLUMN_TYPE.STRING,[xn.SOURCE]:s.COLUMN_TYPE.STRING};async function Mn(e){const t=await Tn(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>Bn(t.rows.get(n))))}async function Tn(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(En))if(t.columns.addNew(e,n),e===xn.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(xn.SYMBOL).semType="Monomer",t.col(xn.SYMBOL).setTag(Pe.Mn.applyToBackground,"true"),t.col(xn.SYMBOL).setTag(pe.qE.polymerTypeColumnName,xn.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=On(e[n].rgroups,e[n].smiles,e[n].molfile);o=_n(o),e[n].rgroups=Rn(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?Nn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(xn.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(xn.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class In{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(xn.NAME).width=100,this.tv.grid.col(xn.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new $n(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(xn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await yn.getInstance();await e.awaitLoaded(),this.instance=new In(e)}return this.instance}static async getNewInstance(){const e=await yn.getInstance();return await e.awaitLoaded(),new In(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewMonomersCollectionDialog(e){const t=(await this.monomerLibManamger.listMonomerCollections()).map(e=>e.toLowerCase()),n=r.input.string("Collection Name",{tooltipText:"Name of the monomer collection, should be unique",placeholder:"Enter collection name",nullable:!1}),i=r.input.string("Description",{tooltipText:"Description of the monomer collection",placeholder:"Enter collection description",nullable:!0}),s=r.dialog("Create New Monomer Collection").add(n).add(i).addButton("Add",async()=>{if(!n.value||!n.value.trim())return void o.shell.warning("Collection name cannot be empty");const a=async e=>{await this.monomerLibManamger.addOrUpdateMonomerCollection(n.value,e,i.value??void 0),o.shell.info(`Collection ${n.value} saved successfully`)};if(t.includes(n.value.toLowerCase())||t.includes(n.value.toLowerCase()+".json")){const t=r.dialog("Collection already exists").add(r.divText(`A collection with the name ${n.value} already exists. Do you want to merge or overwrite it?`));t.addButton("Merge",async()=>{const i=await this.monomerLibManamger.readMonomerCollection(n.value),r=Array.from(new Set([...i.monomerSymbols??[],...e]));try{await a(r)}catch(e){o.shell.error("Error merging monomer collection"),console.error(e)}t.close()}),t.addButton("Overwrite",async()=>{try{await a(e)}catch(e){o.shell.error("Error overwriting monomer collection"),console.error(e)}t.close()}),t.show()}else try{await a(e)}catch(e){o.shell.error("Error creating monomer collection"),console.error(e)}s.close()}).show()}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex,n=e.menu;if(n.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),n.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0){const e=n.group("Selected Monomers");e.item("Remove",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Bn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.item("Create Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Bn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}),e.item("Create Collection",async()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>this.tv.dataFrame.col(xn.SYMBOL).get(e)).filter(e=>!!e&&e.trim().length>0);if(0===e.length)return o.shell.warning("No valid monomer symbols found in selection");this.createNewMonomersCollectionDialog(e)})}else n.item("Remove Monomer",async()=>{const e=await Bn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===In.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:In.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Bn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Bn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=In.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Bn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,ye.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await Tn(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Bn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const Ln=["alternateId","capGroupName","capGroupSMILES","label"];function Nn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Pn(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function Rn(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(Ln,e),n=Nn(t,"capGroupSMILES"),i=Nn(t,"alternateId"),o=Nn(t,"capGroupName"),r=Nn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class $n{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=On([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await It(Hn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Et(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Et(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Rn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&It(Hn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=On(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(xn.POLYMER_TYPE)?.toList()??[],s=n?.col(xn.SYMBOL)?.toList()??[],a=n?.col(xn.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await Bn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await Bn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=On([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=kn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function On(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=_n(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function kn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function Hn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=Nn(e,"capGroupName"),r=Nn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function Bn(e){let t;try{t=JSON.parse(e.get(xn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(xn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=kn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(xn.NATURAL_ANALOG);const a=e.get(xn.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(xn.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=Nn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?Pn(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?Pn(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?Pn(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&Pn(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=Nn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&Pn(e,"capGroupSMILES",`${Nn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await It(Hn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(xn.SYMBOL),name:e.get(xn.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(xn.MONOMER_TYPE),naturalAnalog:r,id:e.get(xn.ID),rgroups:l,meta:t,author:e.get(xn.AUTHOR),createDate:e.get(xn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}var Dn=n(3890),Gn=n(1687);function Vn(e){return e.split(/,(?![^(]*\))/).map(e=>('"'===(e=e.trim()).slice(0,1)&&'"'===e.slice(-1)&&(e=e.slice(1,-1)),"'"===e.slice(0,1)&&"'"===e.slice(-1)&&(e=e.slice(1,-1)),e.trim())).filter(e=>!!e)}class qn{constructor(e,t,n,i){this.currentMenu=null,this.menuItems=[],this.highlightedIndex=-1,this.monomerLib=e,this.polymerType=t,this.helmType=(0,$e.MD)(t),this.allSymbols=e.getMonomerSymbolsByType(t),this.libHelper=i,this.selectedMonomers=n?[...n]:[],this.tagsHost=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px",marginTop:"4px",maxHeight:"150px",overflowY:"auto"}}),this.countLabel=r.divText("",{style:{fontSize:"11px",color:"var(--grey-4)",marginTop:"4px"}});const o=r.input.string("Search",{value:""});this.inputEl=o.input,this.inputEl.setAttribute("autocomplete","off"),this.inputEl.placeholder="Type to search monomers...",this.setupInputListeners();const s=this.createLibrarySection(),a=this.createCollectionSection(),l=r.button("Clear all",()=>{this.selectedMonomers.length=0,this.renderTags()});l.style.fontSize="11px",l.style.marginTop="4px",this.renderTags(),this.root=r.div([o.root,s,a,r.divH([this.countLabel,l],{style:{justifyContent:"space-between",alignItems:"center"}}),this.tagsHost],{style:{minWidth:"300px"}})}getSelectedMonomers(){return[...this.selectedMonomers]}setSelectedMonomers(e){this.selectedMonomers.length=0,this.selectedMonomers.push(...e),this.renderTags()}setPolymerType(e){this.polymerType=e,this.helmType=(0,$e.MD)(e),this.allSymbols=this.monomerLib.getMonomerSymbolsByType(e)}focus(){this.inputEl.focus()}updateCountLabel(){this.countLabel.textContent=this.selectedMonomers.length>0?`${this.selectedMonomers.length} monomer(s) selected`:""}renderTags(){this.tagsHost.innerHTML="";for(const e of this.selectedMonomers){const t=r.iconFA("times",()=>{const t=this.selectedMonomers.indexOf(e);t>=0&&(this.selectedMonomers.splice(t,1),this.renderTags(),this.updateCountLabel())});t.style.marginLeft="4px",t.style.cursor="pointer";const n=r.div([r.span([e]),t],{style:{display:"inline-flex",alignItems:"center",padding:"2px 6px",borderRadius:"4px",backgroundColor:"var(--grey-2)",border:"1px solid var(--grey-3)",fontSize:"12px",cursor:"default"}});n.addEventListener("mouseenter",()=>{const t=this.monomerLib.getTooltip(this.helmType,e);r.tooltip.show(t,n.getBoundingClientRect().left,n.getBoundingClientRect().bottom+16)}),n.addEventListener("mouseleave",()=>{r.tooltip.hide()}),this.tagsHost.appendChild(n)}this.updateCountLabel()}addMonomer(e){this.selectedMonomers.includes(e)||(this.selectedMonomers.push(e),this.renderTags()),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}addMonomers(e){let t=!1;for(const n of e)this.selectedMonomers.includes(n)||(this.selectedMonomers.push(n),t=!0);t&&this.renderTags()}hideMenu(){this.currentMenu&&(this.currentMenu.hide(),this.currentMenu=null),this.menuItems=[],this.highlightedIndex=-1}getSuggestions(e){const t=e.toLowerCase(),n=[];for(const e of this.allSymbols){if(this.selectedMonomers.includes(e))continue;const i=this.monomerLib.getMonomer(this.polymerType,e),o=e.toLowerCase(),r=i?.name?.toLowerCase()??"";o.startsWith(t)?n.push({symbol:e,monomer:i,rank:0}):o.includes(t)?n.push({symbol:e,monomer:i,rank:1}):r.includes(t)&&n.push({symbol:e,monomer:i,rank:2})}return n.sort((e,t)=>e.rank-t.rank||e.symbol.localeCompare(t.symbol)),n.slice(0,20)}showSuggestions(){this.hideMenu();const e=this.inputEl.value.trim();if(!e)return;const t=this.getSuggestions(e);if(0===t.length)return;this.currentMenu=s.Menu.popup();const n=t.reduce((e,t)=>{const n=t.monomer?.name?`${t.symbol} - ${t.monomer.name}`:t.symbol;return e.length<n.length?n:e},"");this.currentMenu.item(n,()=>{});const i=new MouseEvent("mousemove",{clientX:this.inputEl.getBoundingClientRect().left,clientY:this.inputEl.getBoundingClientRect().bottom});this.currentMenu.show({causedBy:i,y:this.inputEl.offsetHeight+this.inputEl.offsetTop,x:this.inputEl.offsetLeft}),setTimeout(()=>{this.currentMenu?.clear();for(const e of t){const t=e.monomer?.name?`${e.symbol} - ${e.monomer.name}`:e.symbol;this.currentMenu?.item(t,()=>{this.addMonomer(e.symbol)})}const e=document.querySelector(".d4-menu-popup:last-of-type");e&&(this.menuItems=Array.from(e.querySelectorAll(".d4-menu-item"))),this.highlightedIndex=-1},0)}updateHighlight(e){0!==this.menuItems.length&&(this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&this.menuItems[this.highlightedIndex].classList.remove("d4-menu-item-hover"),this.highlightedIndex=e,this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&(this.menuItems[this.highlightedIndex].classList.add("d4-menu-item-hover"),this.menuItems[this.highlightedIndex].scrollIntoView({block:"nearest"})))}setupInputListeners(){this.inputEl.addEventListener("input",()=>{this.showSuggestions()}),this.inputEl.addEventListener("paste",e=>{const t=e.clipboardData?.getData("text");if(!t)return;const n=t.split(/[\n\r]+/).map(e=>e.trim()).filter(e=>e.length>0),i=[];for(const e of n){const t=Vn(e);1===t.length&&e.includes(" ")&&!e.includes(",")?i.push(...e.split(/\s+/).map(e=>e.trim()).filter(e=>e.length>0)):i.push(...t)}if(!(i.length<=1)){e.preventDefault();for(const e of i)this.selectedMonomers.includes(e)||this.selectedMonomers.push(e);this.renderTags(),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}}),this.inputEl.addEventListener("keydown",e=>{if("ArrowDown"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex+1)%this.menuItems.length;this.updateHighlight(e)}}else if("ArrowUp"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex-1+this.menuItems.length)%this.menuItems.length;this.updateHighlight(e)}}else if("Enter"===e.key)if(e.preventDefault(),e.stopPropagation(),this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length)this.menuItems[this.highlightedIndex].click();else{const e=this.inputEl.value.trim();e&&this.addMonomer(e)}else"Escape"===e.key&&this.hideMenu()})}createLibrarySection(){const e=r.div([],{style:{marginTop:"8px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from library",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.getAvaliableLibraryNames().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=await t.readSingleLibraryByName(e);if(n){const t=n.getMonomerSymbolsByType(this.polymerType),o=this.selectedMonomers.length;this.addMonomers(t);const r=this.selectedMonomers.length-o;i.textContent=`Added ${r} monomer(s) from "${e}"`}else i.textContent=`Library "${e}" not found`}catch(e){i.textContent="Error loading library"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}createCollectionSection(){const e=r.div([],{style:{marginTop:"4px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from collection",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.listMonomerCollections().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=(await t.readMonomerCollection(e)).monomerSymbols??[],o=this.selectedMonomers.length;this.addMonomers(n);const r=this.selectedMonomers.length-o,s=e.replace(/\.json$/,"");i.textContent=`Added ${r} monomer(s) from "${s}"`}catch(e){i.textContent="Error loading collection"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}}class jn extends s.ObjectHandler{get type(){return"MonomerCollection"}get name(){return"Monomer Collection"}isApplicable(e){return Array.isArray(e)?e.length>0&&e.every(e=>this.isSingleCollection(e)):this.isSingleCollection(e)}isSingleCollection(e){return null!=e&&"object"==typeof e&&"name"in e&&"displayName"in e&&"data"in e&&void 0!==e.data?.monomerSymbols}getCaption(e){return Array.isArray(e)?`${e.length} collections`:e.displayName}renderProperties(e,t=null){return Array.isArray(e)?this.renderMultiProperties(e):this.renderSingleProperties(e)}renderSingleProperties(e){const t=r.accordion("Monomer Collection"),n=s.User.current().login,i=e.data.updatedBy===n;return t.addPane("Details",()=>{const t={Name:e.displayName};if(e.data.description&&(t.Description=e.data.description),e.data.tags&&e.data.tags.length>0&&(t.Tags=e.data.tags.join(", ")),t.Monomers=`${e.data.monomerSymbols.length}`,e.data.updatedBy&&(t["Updated by"]=e.data.updatedBy),e.data.updatedOn)try{t["Updated on"]=new Date(e.data.updatedOn).toLocaleString()}catch{}return r.tableFromMap(t)},!0),t.addPane("Monomers",()=>{const t=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px"}}),n=this.getMonomerLib();for(const i of e.data.monomerSymbols){const e=r.div([i],{style:{display:"inline-block",padding:"2px 8px",borderRadius:"4px",background:"var(--grey-1)",border:"1px solid var(--grey-2)",fontSize:"11px",color:"var(--grey-5)",cursor:"pointer"}});e.addEventListener("mouseenter",()=>{if(n){const t=jn.getMonomerTooltipSafe(n,i);if(t){const n=e.getBoundingClientRect();r.tooltip.show(t,n.left,n.bottom+4)}}}),e.addEventListener("mouseleave",()=>r.tooltip.hide()),e.addEventListener("click",()=>{o.shell.o=s.SemanticValue.fromValueType(i,Ge.uF.MONOMER)}),t.appendChild(e)}return t},!0),t.addPane("Actions",()=>{const t=[],n=r.button("Edit",async()=>{i&&await this.editCollection(e)},i?"Edit this collection":"Only the author can edit");i||jn.disableButton(n),t.push(n);const o=r.button("Delete",async()=>{i&&await this.deleteCollection(e)},i?"Delete this collection":"Only the author can delete");return i||jn.disableButton(o),t.push(o),t.push(r.button("Duplicate",async()=>{await this.duplicateCollection(e)},"Create a copy of this collection")),r.divH(t)},!0),t.root}renderMultiProperties(e){const t=r.accordion("Monomer Collections"),n=s.User.current().login,i=e.every(e=>e.data.updatedBy===n);return t.addPane("Selection",()=>{const t=r.list(e.map(e=>e.displayName));return r.divV([r.divText(`${e.length} collections selected`),t])},!0),t.addPane("Actions",()=>{const t=[];t.push(r.button("Merge",async()=>{await this.mergeCollections(e)},"Merge selected collections into one"));const n=r.button("Delete All",async()=>{i&&await this.deleteMultipleCollections(e)},i?"Delete all selected collections":"Only the author can delete (you must be author of all)");return i||jn.disableButton(n),t.push(n),r.divH(t)},!0),t.root}async editCollection(e){const t=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(t&&t._mcView)t._mcView.editCollectionPublic(e.name,e.data);else{const t=await yn.getInstance();await t.awaitLoaded();const n=t.getMonomerLib();this.showEditDialog(e,t,n)}}showEditDialog(e,t,n){const i=r.input.string("Name",{value:e.displayName,nullable:!1}),s=r.input.string("Description",{value:e.data.description??"",nullable:!0}),a=r.input.string("Tags",{value:(e.data.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new qn(n,l.value,[...e.data.monomerSymbols??[]],t);l.onChanged.subscribe(()=>c.setPolymerType(l.value)),r.dialog({title:`Edit Collection: ${e.displayName}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const n=i.value?.trim();if(!n)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=this.parseTags(a.value);try{n!==e.displayName&&await t.deleteMonomerCollection(e.name),await t.addOrUpdateMonomerCollection(n,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${n}" saved successfully`),await this.refreshView()}catch(e){o.shell.error("Error saving collection")}}).show({resizable:!0}).root.style.width="550px",c.focus()}async deleteCollection(e){r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete "${e.displayName}"?`)).onOK(async()=>{try{const t=await yn.getInstance();await t.deleteMonomerCollection(e.name),o.shell.info(`Collection "${e.displayName}" deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collection")}}).show()}async duplicateCollection(e){const t=r.input.string("New Name",{value:`${e.displayName} (copy)`,nullable:!1});r.dialog({title:"Duplicate Collection"}).add(t).onOK(async()=>{const n=t.value?.trim();if(n)try{const t=await yn.getInstance();await t.addOrUpdateMonomerCollection(n,[...e.data.monomerSymbols],e.data.description,e.data.tags?[...e.data.tags]:void 0),o.shell.info(`Collection "${n}" created`),await this.refreshView()}catch(e){o.shell.error("Error duplicating collection")}else o.shell.warning("Name is required")}).show()}async mergeCollections(e){const t=r.input.string("Merged Name",{value:"Merged Collection",nullable:!1}),n=r.input.string("Description",{nullable:!0,placeholder:"Optional description"});r.dialog({title:`Merge ${e.length} Collections`}).add(r.divV([r.divText(`Merging: ${e.map(e=>e.displayName).join(", ")}`),t,n])).onOK(async()=>{const i=t.value?.trim();if(i)try{const t=[...new Set(e.flatMap(e=>e.data.monomerSymbols))],r=[...new Set(e.flatMap(e=>e.data.tags??[]))],s=await yn.getInstance();await s.addOrUpdateMonomerCollection(i,t,n.value??void 0,r.length>0?r:void 0),o.shell.info(`Merged collection "${i}" created with ${t.length} monomers`),await this.refreshView()}catch(e){o.shell.error("Error merging collections")}else o.shell.warning("Name is required")}).show()}async deleteMultipleCollections(e){r.dialog({title:"Delete Collections"}).add(r.divText(`Are you sure you want to delete ${e.length} collections?\n${e.map(e=>e.displayName).join(", ")}`)).onOK(async()=>{try{const t=await yn.getInstance();for(const n of e)await t.deleteMonomerCollection(n.name);o.shell.info(`${e.length} collections deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collections")}}).show()}async refreshView(){const e=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(e&&e._mcView){const t=e._mcView;await t.refresh()}}parseTags(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}getMonomerLib(){return ys.monomerLib??null}static getMonomerTooltipSafe(e,t){const n=[He.o.AA,He.o.NUCLEOTIDE,He.o.CHEM,He.o.BLOB];for(const i of n)try{if(e.getWebEditorMonomer(i,t))return e.getTooltip(i,t)}catch{}return null}static disableButton(e){e.style.opacity="0.4",e.style.cursor="default"}static buildContextMenu(e,t,n){const i=s.User.current().login,o=t.data.updatedBy===i;e.item("Edit",()=>{o&&n.editCollection(t)},null,{isEnabled:()=>o?null:"Only the author can edit"}),e.item("Delete",()=>{o&&n.deleteCollection(t)},null,{isEnabled:()=>o?null:"Only the author can delete"}),e.item("Duplicate",()=>n.duplicateCollection(t))}static buildMultiContextMenu(e,t,n){const i=s.User.current().login,o=t.every(e=>e.data.updatedBy===i);e.item("Merge",()=>n.mergeCollections(t)),e.item("Delete All",()=>{o&&n.deleteMultipleCollections(t)},null,{isEnabled:()=>o?null:"Only the author can delete (you must be author of all)"})}}var Un=n(1757),Wn=n.n(Un);class zn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Yn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new zn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Kn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Kn._instance||(Kn._instance=new Kn,await Kn._instance.refresh(),(await yn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Kn._instance.refresh())),Kn._instance.refresh(),Kn._instance}async refresh(){this.settings=await(0,_e.u)();const e=await yn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Yn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,_e.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,_e.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Zn=n(3017),Xn={};async function Jn(){await ii.showDialog()}async function Qn(e=!0){return await oi.showView(e)}Xn.styleTagTransform=C(),Xn.setAttributes=y(),Xn.insert=g().bind(null,"head"),Xn.domAPI=m(),Xn.insertStyleElement=v(),h()(Zn.A,Xn),Zn.A&&Zn.A.locals&&Zn.A.locals;class ei{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==ei.instancePromise&&(ei.instancePromise=(async()=>{const e=new ei,t=await(0,ye.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),ei.instancePromise}static async reloadWidget(){const e=await ei.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,ye.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await ti.createControlsForm();return Wn()(e).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),setTimeout(()=>{e&&Wn()(e)&&Wn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class ti{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){ys.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,_e.u)(),t=await(0,ye.pj)();return new ti(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Wn()(t).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),t}async updateControlsForm(){const e=await this._createControlsForm();Wn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;ys.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{ni(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=r.icons.edit(async()=>{o.shell.v=await(await In.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),ys.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await ni(!1,e);const n=await(0,ye.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function ni(e,t){const n=await(0,_e.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,_e.E)(n);const i=await(0,ye.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class ii{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){ii._instance||(ii._instance=new ii,ii._instance.closeDialogSubject$.subscribe(()=>{ii._instance.dialog=void 0})),ii._instance.dialog||(ii._instance.dialog=await ii._instance.getDialog()),ii._instance.dialog.show()}async getDialog(){const e=(await ei.getInstance()).widget,t=await(0,ye.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Wn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class oi{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await ei.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=oi.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=oi._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return oi._instance||(oi._instance=new oi),oi._instance._duplicateManager||(oi._instance._duplicateManager=await Kn.getInstance()),oi._instance.libManager||(oi._instance.libManager=await yn.getInstance()),e&&oi._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===oi._instance._view.id)?(o.shell.v=oi._instance._view,await oi._instance._duplicateManager.refresh(),oi._instance._view):(oi.closeExistingViews(),oi._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===oi.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await yn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,_e.u)();i.exclude=l,await(0,_e.E)(i),await this.libManager.loadMonomerLib(!0),await ei.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var ri,si=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ai{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>si(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>si(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>si(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>si(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,ai.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return si(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield s.delay(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep===this.stepNumber)return this._restartBtn.disabled=!1,void(this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn));if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))})}_startScript(){return si(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return si(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return si(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return si(this,void 0,void 0,function*(){this._restartBtn.disabled=!0,o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ai.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return si(this,void 0,void 0,function*(){var e;(null===(e=o.shell.v)||void 0===e?void 0:e.name)===this.name&&o.shell.v.close(),this._initRoot(),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ai.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(ri||(ri={}));var li=n(966),ci=n(608),ui=n(1619);class hi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${ys.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case et.n5.fixWidth:case et.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class di{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var mi=n(6869);const pi="-";class gi extends De{constructor(e,t){super(e,t)}static _canonLoadingKey=pe.sc+".loading";getCanonicalizer(e){const t=e.temp[pe.sc]??null;if(t)return t;if(e.temp[gi._canonLoadingKey])return null;const n=e.getTag(pe.jz);if(!n)return null;const i=n.includes(":")?n.split(":"):[void 0,n],o=s.Func.find({name:i[1],package:i[0]});return 0===o.length||(e.temp[gi._canonLoadingKey]=!0,o[0].apply({}).then(t=>{e.temp[pe.sc]=t,e.temp[gi._canonLoadingKey]=!1,this.gridCol?.grid?.invalidate&&this.gridCol.grid.invalidate()}).catch(()=>{e.temp[gi._canonLoadingKey]=!1})),null}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Pe.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";const a=e.measureText("M"),l=a.actualBoundingBoxAscent+a.actualBoundingBoxDescent+8;let c=r.cell.value;c&&c!==pe._S||(c=pi);const u=c.split(pe.ot).map(e=>e&&e!==pe._S?e.trim():pi),h=u.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/u.length)))),d=h.map(t=>e.measureText(t).width+4),m=d.reduce((e,t)=>e+t,0);let p=t+(i-m)/2+2;const g=this.tableCol.getTag(pe.gp.alphabet),f=g===ue.YI.RNA||g===ue.YI.DNA?mi.o.NUCLEOTIDE:mi.o.AA;for(let a=0;a<h.length;a++){const c=u[a],m=this.getHelmType(r,f);let g=Re.S$,y="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,c);g=e?.textcolor??g,y=e?.backgroundcolor??y}else g=this.monomerLib.getMonomerTextColor(m,c);if(s)if(e.fillStyle=y,i<30||o<30)e.fillRect(t+a*i/h.length,n,i/h.length,o);else{const t=2;e.roundRect(p-2,n+o/2-l/2,d[a],l,t),e.fill()}e.fillStyle=g,e.fillText(h[a],p,n+o/2,i),p+=d[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,ke.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(pe.gp.alphabet),a=e.cell.value,l=this.getCanonicalizer(i),c=l&&a?l.canonicalize(a):a,u=e.grid.canvas.getBoundingClientRect(),h=e.bounds.right+u.left-4,d=e.bounds.bottom+u.top-4;if(!a||a==pe._S||a==pi||null!=l&&l.isGap(a))return r.tooltip.show(r.divText("gap"),h,d),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),h,d),!0;const m=s===ue.YI.RNA||s===ue.YI.DNA?mi.o.NUCLEOTIDE:mi.o.AA,p=c.split(pe.ot).map(t=>{if(!t||t===pe._S||t===pi)return r.divText("gap");const n=this.getHelmType(e,m);return this.monomerLib.getTooltip(n,t)}),g=r.divH(p,{style:{alignItems:"top"}}),f=Array.from(g.querySelectorAll("canvas"));if(f.length>2){const e=Math.floor(550/f.length);f.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(g,h,d),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,ke.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(pe.qE.polymerTypeColumnName)){const t=o.getTag(pe.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,$e.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new gi(t,n)),o}}class fi extends s.GridCellRenderer{get name(){return Ge.uF.MONOMER}get cellType(){return Ge.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){gi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){gi.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class yi{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class bi extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class vi extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new yi(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ve.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var wi=n(6307),Ci=n(5999),Ai={};Ai.styleTagTransform=C(),Ai.setAttributes=y(),Ai.insert=g().bind(null,"head"),Ai.domAPI=m(),Ai.insertStyleElement=v(),h()(Ci.A,Ai),Ci.A&&Ci.A.locals&&Ci.A.locals;class Si extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=ys.properties.tooltipWebLogo,n=this.seqCol.getTag(Xe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}var xi=n(4951);function Ei(e,t,n,i){const o=ys.seqHelper.getSeqHandler(e);let r=null,a=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(a=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==a&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<a)throw new Error(`End position ${a} exceeds positions length`);const l=i||`${e.name}: (${t??""}-${n??""})`,c=function(e,t,n,i,o){if(!n||!i||!e.dataFrame)return null;const r=e.getTag(ue.gp.annotations);if(!r)return null;let a;try{a=JSON.parse(r)}catch{return null}const l=a.find(e=>e.category===xt.eI.Structure&&e.start===n&&e.end===i);if(!l)return null;const c=(0,St.VT)(e.name);let u=null;try{u=e.dataFrame.columns.byName(c)}catch{return null}if(!u)return null;const h=(0,St.wi)(u);if(!h.some(e=>e?.some(e=>e.annotationId===l.id&&null!=e.endPositionIndex)))return null;const d=e.dataFrame,m=s.Column.fromType(s.COLUMN_TYPE.STRING,o,d.rowCount);for(let e=0;e<d.rowCount;e++){const n=h[e],i=n?.find(e=>e.annotationId===l.id&&null!=e.endPositionIndex);if(i){const n=t.getSplitted(e),o=[];for(let e=i.positionIndex;e<=i.endPositionIndex;e++)e<n.length&&o.push(n.getOriginal(e));m.set(e,o.join(t.separator||""))}else m.set(e,"")}return m}(e,o,t,n,l);return c||o.getRegion(r,a,l)}const Mi={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Ti{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??Mi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${ys.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Ii{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value;let t=null;const n=e?e.getTag(ue.gp.annotations):null;if(n)try{const e=JSON.parse(n).filter(e=>"structure"===e.category&&e.start&&e.end);e.length>0&&(t=e.map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end})))}catch{}if(!t){const n=e?e.getTag(ue.gp.regions):null;t=n?JSON.parse(n):null}const i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=t){this.inputs.region.root.style.removeProperty("display");for(const e of t){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{ys.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{ys.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var _i=n(8754);async function Li(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=ge(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):pe._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=ge(e,n).columns.toList());const i=(await(0,ye.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):pe._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==pe._S&&t!==p?l[e]+=y[t]:c===pe._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null==u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Ni=n(294),Pi=n(330);const Ri=OCL;var $i=n(2582);class Oi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var ki=n(6956);class Hi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===ki.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=$t.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const v=new Map;v.set(p+1,e+1);let w=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),v.set(e+1,w),w++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=v.get(t),o=v.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Bi{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Fi extends Bi{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class Di{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Gi extends Di{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Vi extends Oi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Fi(n),this.bonds=new Gi(n),this.rGroups=new Hi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class qi extends Bi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class ji extends Di{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Ui extends Oi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new qi(n),this.bonds=new ji(n),this.rGroups=new Hi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Wi{static getInstance(e,t){if($t.isMolfileV2K(e))return new Vi(e,t);if($t.isMolfileV3K(e))return new Ui(e,t);throw new Error("Unsupported molfile version")}}class zi{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Wi.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(zi.molfileV2KToV3KCache.has(e))return zi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return zi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Yi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new $i.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===pe.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new zi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Ni.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?He.o.NUCLEOTIDE:He.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Ki{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Zi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Ri.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,ve.AP)(e);return ys.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,Pi.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Ni.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,ve.AP)(e);ys.logger.error(t,void 0,n),o=Ni.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Ki(o),s=new Yi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Ni.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Ni.vF(a.molfile,l)}}var Xi=n(2738);class Ji{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[me.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}runInnerDetector(){if(!this._column.temp.seqHandlerDetectorRun){this._column.temp.seqHandlerDetectorRun=!0;const e=s.Func.find({name:"detectMacromolecule",meta:{role:"semTypeDetector"}})[0];e&&e.applySync({col:this._column})}}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;let n=this._column.meta.units;if(!n&&(this.runInnerDetector(),n=this._column.meta.units,!n))throw new Error("Units are not specified in column");if(this._units=n,this._notation=this.getNotation(),[ue.Hi.BILN,ue.Hi.CUSTOM,ue.Hi.SEPARATOR].includes(this._notation)&&!this.column.getTag(ue.gp.separator)&&(this.runInnerDetector(),!this.column.getTag(ue.gp.separator)))throw new Error(`Separator tag '${ue.gp.separator}' is not set for notation '${this._notation}'.`);(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[me.j.notationProvider]??null);const i=this.isFasta()?pe.b9[ue.Hi.FASTA]:this.isSeparator()?pe.b9[ue.Hi.SEPARATOR]:this.isHelm()?pe.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??pe.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[me.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.BILN].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength||e.column.categories.slice(0,5).filter(e=>!!e).every(e=>e.length>100)?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,$e.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new Xi.aD(e.name,e.alphabet,.9));t=(0,$e.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?He.o.NUCLEOTIDE:He.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===pe.b9[ue.Hi.FASTA]?pe._S:i??pe._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(pe._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===pe.b9[ue.Hi.FASTA]?pe._S:o??pe._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new me.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!Ji.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:$e.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?pe.b9[ue.Hi.FASTA]:pe.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===pe.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=pe.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new $e.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Qi(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return eo(n,t,e)};break}case ue.Hi.BILN:i=function(e){return to(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[me.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[me.j.seqHandler]=new Ji(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Qi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return eo(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:to(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new $e.Mu(n.filter(e=>!!e),pe.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Qi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function eo(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===pe._S?r=pe.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===pe._S?s=pe.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function to(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class no{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Ji.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,kt.b2)();return new Zi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Ni.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Ni.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Ni.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Ni.vF(e,o.monomers)}catch(e){const[t,n]=(0,ve.AP)(e);return ys.logger.error(t,void 0,n),Ni.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,Pi.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,Ji.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),Ji.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,Ji.setTags(e)}}async function io(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await vs.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[me.j.notationProvider]&&(i.temp[me.j.notationProvider]=e.cell.column.temp[me.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await vs.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){ys.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const oo="#333333",ro="rgba(60, 177, 115, 0.1)",so="rgba(240, 240, 240, 0.5)",ao="rgba(100, 100, 100, 0.3)";class lo{constructor(e=ho.DEFAULT_TRACK_HEIGHT,t=ho.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class co extends lo{constructor(e=new Map,t=ho.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,ho.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=He.o.NUCLEOTIDE;break;default:t=He.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,wi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=ro,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=so,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=ao,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class uo extends lo{constructor(e,t=ho.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,ho.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=ro,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=so,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=ao,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=oo,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const ho={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35,ANNOTATION_TRACK_HEIGHT:20},mo={BASE:ho.DOTTED_CELL_HEIGHT+ho.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+ho.TITLE_HEIGHT+ho.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+ho.DEFAULT_TRACK_HEIGHT+ho.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+ho.DEFAULT_TRACK_HEIGHT+ho.TRACK_GAP}};class po{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||mo.BASE,sliderHeight:e.sliderHeight||ho.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0,dragMode:"none",dragStartWindowPosition:1,dragOccurred:!1},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation"),i=this.getTrack("annotations");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(ho.DEFAULT_TRACK_HEIGHT)}),e<mo.WITH_TITLE())return;let o=0;i&&(i.setVisible(!0),i.setHeight(ho.ANNOTATION_TRACK_HEIGHT),o=ho.ANNOTATION_TRACK_HEIGHT+ho.TRACK_GAP);const r=mo.WITH_WEBLOGO()+o,s=mo.WITH_BOTH()+o;if(!(e<r))if(e<s){if(t){t.setVisible(!0);const n=e-r;t.setHeight(ho.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>s){const n=e-s;t.setHeight(ho.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<r&&t&&t.setVisible(!1),e<s&&n&&n.setVisible(!1))}}drawTrackButtons(){const e=70;if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),n=this.getTrack("weblogo"),i=this.getTrack("annotations"),o=t?.isVisible()??!1,r=n?.isVisible()??!1,s=i?.isVisible()??!1;let a=this.config.width-16;const l=this.config.headerHeight>=mo.WITH_TITLE()?(ho.TITLE_HEIGHT-14)/2:2;o&&r||(!o&&t&&(a-=e,this.drawTrackButton("conservation","Conservation",a,l,e,14),a-=4),!r&&n&&(a-=e,this.drawTrackButton("weblogo","WebLogo",a,l,e,14),a-=4)),!s&&i&&(a-=e,this.drawTrackButton("annotations","Annotations",a,l,e,14))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=mo.WITH_TITLE()?ho.TITLE_HEIGHT:0)}snapToTrackHeight(e){const t=this.getTrack("annotations")?ho.ANNOTATION_TRACK_HEIGHT+ho.TRACK_GAP:0;let n;if("annotations"===e)n=mo.WITH_TITLE()+t;else if("weblogo"===e)n=mo.WITH_WEBLOGO()+t;else{if("conservation"!==e)return;n=mo.WITH_BOTH()+t}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]="annotations"===t})),"annotations"===e?this.userSelectedTracks.annotations=!0:"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(n),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.getTrack("annotations")?ho.ANNOTATION_TRACK_HEIGHT+ho.TRACK_GAP:0,t=this.tracks.size>0?mo.WITH_BOTH()+e:mo.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=mo.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,ho.TITLE_HEIGHT),this.ctx.fillStyle=oo,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+ho.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof co&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=mo.WITH_TITLE()?ho.TITLE_HEIGHT:0,l=this.config.headerHeight-ho.SLIDER_HEIGHT-ho.DOTTED_CELL_HEIGHT,c=l-ho.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[];this.tracks.forEach((e,t)=>{e.isVisible()&&d.push({id:t,track:e})});let m=c;for(const{id:e,track:t}of d){const i=m-t.getHeight();if(n>=i&&n<m){u=e,h=n-i;break}m=i-ho.TRACK_GAP}let p=null;if(u){const e=this.tracks.get(u);e&&(p=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==p)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=p,u)){const e=this.tracks.get(u);e instanceof co&&(e.setHovered(s,p),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||p!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=p,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,p);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=mo.WITH_TITLE();l&&ho.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-ho.SLIDER_HEIGHT,u=c-ho.DOTTED_CELL_HEIGHT,h=u-ho.TRACK_GAP,d=[],m=[];this.tracks.forEach((e,t)=>{e.isVisible()&&m.push({id:t,track:e})});let p=h;for(const{track:e}of m){const t=e.getHeight(),i=p-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),p=i-ho.TRACK_GAP}if(this.drawDottedCells(0,u,n,ho.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:ho.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+ho.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=oo,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,ho.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,ho.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,ho.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-ho.SLIDER_HEIGHT;return t>n&&t<n+ho.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-ho.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+ho.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.state.isDragging&&"header"===this.state.dragMode?this.eventElement.style.cursor="grabbing":this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)?this.eventElement.style.cursor="pointer":this.isInHeaderArea(e)?this.eventElement.style.cursor="grab":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(this.state.dragOccurred)return;if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=mo.WITH_TITLE()?ho.TITLE_HEIGHT:0,a=this.config.headerHeight-ho.SLIDER_HEIGHT-ho.DOTTED_CELL_HEIGHT,l=a-ho.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-ho.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=mo.WITH_TITLE()&&t&&(go(e.left??0,n,i)||go(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e);this.isInSliderDraggableArea(e)?(this.state.isDragging=!0,this.state.dragMode="slider",this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()):this.isInHeaderArea(e)&&!this.isInSliderArea(e)&&(this.state.isDragging=!0,this.state.dragMode="header",this.state.dragStartX=t,this.state.dragStartWindowPosition=this.config.windowStartPosition,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;if(this.state.dragOccurred=!0,"slider"===this.state.dragMode)this.handleSliderDrag(n);else if("header"===this.state.dragMode){const e=n-this.state.dragStartX,t=Math.round(e/this.config.positionWidth),i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-i+1;this.config.windowStartPosition=Math.max(1,Math.min(o,this.state.dragStartWindowPosition-t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1,this.state.dragMode="none",this.state.dragOccurred&&setTimeout(()=>{this.state.dragOccurred=!1},0)}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(this.state.dragOccurred)return;if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(this.isInsideColumnHeaderArea(t,n))this.seqColumn&&(o.shell.o=this.seqColumn);else if(n<this.config.headerHeight-ho.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:mo.BASE,WITH_TITLE:mo.WITH_TITLE(),WITH_WEBLOGO:mo.WITH_WEBLOGO(),WITH_BOTH:mo.WITH_BOTH()}}}function go(e,t,n){return e>=t&&e<=n}class fo extends lo{constructor(e,t="Annotations"){super(20,14,t),this.tableCol=e,this.regions=[],this.posList=[],this._cacheVersion=-1,this._rebuildRegions()}hasRegions(){return this._ensureUpToDate(),this.regions.length>0}getRegionAtPosition(e){this._ensureUpToDate();for(const t of this.regions)if(e>=t.startIdx&&e<=t.endIdx)return t;return null}getTooltipContent(e,t){this._ensureUpToDate();const n=this.getRegionAtPosition(e);if(!n)return null;const i=n.sourceScheme??"",o=e<this.posList.length?this.posList[e]:"",s=[],a=document.createElement("b");return a.textContent=n.name,s.push(r.div([a],{style:{fontSize:"13px",marginBottom:"4px"}})),i&&s.push(r.divText(`Scheme: ${i}`,{style:{fontSize:"12px",color:"#555"}})),s.push(r.divText(`Range: ${n.startPos} – ${n.endPos}`,{style:{fontSize:"12px",color:"#555"}})),o&&s.push(r.divText(`Position: ${o}`,{style:{fontSize:"12px",color:"#555"}})),n.description&&s.push(r.divText(n.description,{style:{fontSize:"11px",color:"#888",marginTop:"2px"}})),r.divV(s,{style:{padding:"4px"}})}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible)return;if(this._ensureUpToDate(),0===this.regions.length)return;const l=this.ctx;l.save(),l.beginPath(),l.rect(e,t,n,i),l.clip();const c=o-1,u=c+Math.ceil(n/r)+2;for(const n of this.regions){if(n.endIdx<c||n.startIdx>u)continue;const o=Math.max(n.startIdx,c),s=e+(o-c)*r,a=(Math.min(n.endIdx,u)-o+1)*r;l.fillStyle=n.color,l.globalAlpha=.35,l.fillRect(s,t,a,i),l.globalAlpha=1,l.strokeStyle=n.color,l.globalAlpha=.6,l.lineWidth=1,l.strokeRect(s+.5,t+.5,a-1,i-1),l.globalAlpha=1,l.font="bold 9px Roboto, Roboto Local, sans-serif",a>l.measureText(n.name).width+4&&(l.fillStyle="#333",l.textAlign="center",l.textBaseline="middle",l.fillText(n.name,s+a/2,t+i/2))}l.restore()}_ensureUpToDate(){this._cacheVersion!==this.tableCol.version&&(this._rebuildRegions(),this._cacheVersion=this.tableCol.version)}_rebuildRegions(){this.regions=[];const e=this.tableCol.getTag(pe.gp.annotations);if(!e)return;let t;try{t=JSON.parse(e)}catch{return}if(this.posList=this._getPosList(),0!==this.posList.length)for(const e of t){if(e.category!==xt.eI.Structure)continue;if(null==e.start||null==e.end)continue;const t=this.posList.indexOf(e.start),n=this.posList.indexOf(e.end);t<0||n<0||this.regions.push({name:e.name,color:e.color??this._defaultColor(e),startIdx:t,endIdx:n,startPos:e.start,endPos:e.end,sourceScheme:e.sourceScheme,description:e.description})}}_getPosList(){const e=this.tableCol.getTag(pe.gp.positionNames);return e?e.split(", "):[]}_defaultColor(e){if(e.name.startsWith("CDR")){const t=parseInt(e.name.replace("CDR",""))-1;return xt.D5.structure.CDR[t%xt.D5.structure.CDR.length]}if(e.name.startsWith("FR")){const t=parseInt(e.name.replace("FR",""))-1;return xt.D5.structure.FR[t%xt.D5.structure.FR.length]}return"#90CAF9"}}class yo{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){yo.conservationCache=new s.LruCache(100),yo.webLogoCache=new s.LruCache(100),yo.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return yo.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return yo.conservationCache.getOrCreate(i,()=>{const o=yo.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return yo.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/yo.CHUNK_SIZE)*yo.CHUNK_SIZE,s=Math.ceil(n/yo.CHUNK_SIZE)*yo.CHUNK_SIZE;for(let t=r;t<s;t+=yo.CHUNK_SIZE){const n=Math.min(t+yo.CHUNK_SIZE,i),r=yo.getChunkCacheKey(e.column,t,n),s=yo.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/yo.CHUNK_SIZE)*yo.CHUNK_SIZE,s=Math.ceil(n/yo.CHUNK_SIZE)*yo.CHUNK_SIZE;for(let t=r;t<s;t+=yo.CHUNK_SIZE){const n=Math.min(t+yo.CHUNK_SIZE,i),r=yo.getChunkCacheKey(e.column,t,n),s=yo.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class bo extends co{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=yo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=yo.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class vo extends uo{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=yo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=yo.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const wo="__msa-scroller-initialized",Co="__msa-scroller-subscription";class Ao extends Xi.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return pe.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=$e.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:pe.Hi.HELM})(n)}createCellRendererBack(e,t){const n=ys.properties.maxMonomerLength||4,i=new So(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class So extends Re.Jy{constructor(e,t,n,i){super(e,t,ys.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Re.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:$e.zS}})}}var xo,Eo,Mo=n(6520),To={};To.styleTagTransform=C(),To.setAttributes=y(),To.insert=g().bind(null,"head"),To.domAPI=m(),To.insertStyleElement=v(),h()(Mo.A,To),Mo.A&&Mo.A.locals&&Mo.A.locals;class Io{view=null;libHelper=null;monomerLib=null;collectionNames=[];filteredNames=[];displayedCount=0;cardsContainer=null;loadMoreContainer=null;searchInput=null;currentUser="";collectionsCache=new Map;selectedCollections=new Set;cardElements=new Map;handler=new jn;static VIEW_NAME="Monomer Collections";async init(){this.libHelper=await yn.getInstance(),await this.libHelper.awaitLoaded(),this.monomerLib=this.libHelper.getMonomerLib(),this.currentUser=s.User.current().login,this.view=s.View.create(),this.view.name=Io.VIEW_NAME,this.view._mcView=this;const e=r.icons.add(()=>this.showAddCollectionDialog(),"Create new monomer collection"),t=r.iconFA("sync",()=>this.refresh(),"Refresh collections");return this.view.setRibbonPanels([[e,t]]),this.view.root.addEventListener("contextmenu",e=>{const t=e.target;if(t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card"))return;e.preventDefault();const n=s.Menu.popup();n.item("New Collection...",()=>this.showAddCollectionDialog()),n.item("Refresh",()=>this.refresh()),n.show()}),this.view.root.addEventListener("click",e=>{const t=e.target;t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card")||this.clearSelection()}),this.view.root.tabIndex=0,this.view.root.addEventListener("keydown",e=>{"Escape"===e.key&&this.clearSelection()}),await this.buildContent(),this.view}async buildContent(){if(!this.view)return;this.view.root.innerHTML="";const e=r.div([],{classes:"monomer-collections-view"});this.searchInput=r.input.string("Monomer Collections",{value:"",placeholder:"Search by name or tag..."}),this.searchInput.root.classList.add("monomer-collections-search");const t=this.searchInput.input;t.style.width="100%",t.style.marginBottom="12px";let n=null;t.addEventListener("input",()=>{n&&clearTimeout(n),n=setTimeout(()=>this.applyFilter(),250)}),this.cardsContainer=r.div([],{classes:"monomer-collections-grid"}),this.loadMoreContainer=r.div([],{classes:"monomer-collections-load-more"}),e.appendChild(this.searchInput.root),e.appendChild(this.cardsContainer),e.appendChild(this.loadMoreContainer),this.view.root.appendChild(e),await this.loadCollections()}async loadCollections(){try{this.collectionNames=await this.libHelper.listMonomerCollections()}catch(e){ys.logger.error(`Error listing monomer collections: ${e instanceof Error?e.message:e.toString()}`),o.shell.error("Error loading monomer collections"),this.collectionNames=[]}this.collectionsCache.clear();for(const e of this.collectionNames)this.libHelper.readMonomerCollection(e).then(t=>{this.collectionsCache.set(e,t)}).catch(()=>{});this.applyFilter()}applyFilter(){const e=(this.searchInput?.value??"").trim().toLowerCase();this.filteredNames=e?this.collectionNames.filter(t=>{if(t.replace(/\.json$/i,"").toLowerCase().includes(e))return!0;const n=this.collectionsCache.get(t);return!!n?.tags?.some(t=>t.toLowerCase().includes(e))}):[...this.collectionNames],this.displayedCount=0,this.cardsContainer.innerHTML="",this.cardElements.clear(),this.showNextPage()}showNextPage(){const e=Math.min(this.displayedCount+19,this.filteredNames.length);for(let t=this.displayedCount;t<e;t++){const e=this.createCollectionCard(this.filteredNames[t]);this.cardsContainer.appendChild(e),this.cardElements.set(this.filteredNames[t],e)}this.displayedCount=e;const t=this.cardsContainer.querySelector(".monomer-collection-add-card");t&&t.remove(),this.cardsContainer.appendChild(this.createAddCard());const n=this.cardsContainer.querySelector(".monomer-collection-empty-state");if(n&&n.remove(),0===this.filteredNames.length){const e=0===this.collectionNames.length?'No monomer collections found. Click "+" to create one.':"No collections match your search.",t=r.div([r.divText(e)],{classes:"monomer-collection-empty-state"});this.cardsContainer.prepend(t)}if(this.loadMoreContainer.innerHTML="",this.displayedCount<this.filteredNames.length){const e=this.filteredNames.length-this.displayedCount,t=r.button(`Load more (${e} remaining)`,()=>this.showNextPage());this.loadMoreContainer.appendChild(t)}}createCollectionCard(e){const t=e.replace(/\.json$/i,""),n=r.div([t],{classes:"monomer-collection-card-title"});r.tooltip.bind(n,t);const i=r.div([n],{classes:"monomer-collection-card-header"}),a=r.div([],{classes:"monomer-collection-card-body"}),l=r.div([],{classes:"monomer-collection-card-actions"}),c=r.div([i,a,l],{classes:"monomer-collection-card"});c.dataset.collectionName=e,this.selectedCollections.has(e)&&c.classList.add("monomer-collection-card-selected"),c.addEventListener("click",t=>{const n=t.target;n.closest(".monomer-collection-card-actions")||n.closest(".monomer-collection-tag")||(t.stopPropagation(),this.handleCardClick(e,t.ctrlKey||t.metaKey))}),c.addEventListener("contextmenu",t=>{t.preventDefault(),t.stopPropagation(),this.selectedCollections.has(e)||this.handleCardClick(e,!1),this.showCardContextMenu(t)});const u=async()=>{const t=await this.libHelper.readMonomerCollection(e);if(this.collectionsCache.set(e,t),t.description){const e=r.div([t.description],{classes:"monomer-collection-card-description"});r.tooltip.bind(e,t.description),i.appendChild(e)}if(t.tags&&t.tags.length>0){const e=r.div([],{classes:"monomer-collection-card-tags"});for(const n of t.tags){const t=r.div([n],{classes:"monomer-collection-card-tag"});e.appendChild(t)}i.appendChild(e)}const n=[];if(t.updatedBy&&n.push(`by ${t.updatedBy}`),t.updatedOn)try{n.push(new Date(t.updatedOn).toLocaleDateString())}catch{}n.length>0&&i.appendChild(r.div([n.join(" | ")],{classes:"monomer-collection-card-meta"}));const a=r.div([],{classes:"monomer-collection-tags"}),c=t.monomerSymbols??[];for(const e of c){const t=r.div([e],{classes:"monomer-collection-tag"});t.addEventListener("mouseenter",()=>{if(this.monomerLib){const n=this.getMonomerTooltipSafe(e);if(n){const e=t.getBoundingClientRect();r.tooltip.show(n,e.left,e.bottom+4)}}}),t.addEventListener("mouseleave",()=>r.tooltip.hide()),t.addEventListener("click",t=>{t.stopPropagation(),o.shell.o=s.SemanticValue.fromValueType(e,Ge.uF.MONOMER)}),a.appendChild(t)}const u=r.divText(`${c.length} monomer(s)`,{style:{fontSize:"11px",color:"var(--grey-4)",marginBottom:"6px"}}),h=r.divV([u,a]),d=t.updatedBy===this.currentUser,m=r.button("Edit",()=>{d&&this.showEditCollectionDialog(e,t)}),p=r.button("Delete",()=>{d&&this.confirmDeleteCollection(e)});if(!d){for(const e of[m,p])e.style.opacity="0.4",e.style.cursor="default";r.tooltip.bind(m,"Only the author can edit"),r.tooltip.bind(p,"Only the author can delete")}return l.appendChild(m),l.appendChild(p),h};return a.appendChild(r.wait(()=>u())),c}handleCardClick(e,t){t?this.selectedCollections.has(e)?this.selectedCollections.delete(e):this.selectedCollections.add(e):(this.selectedCollections.clear(),this.selectedCollections.add(e)),this.updateCardSelectionStyles(),this.setCurrentObject()}clearSelection(){this.selectedCollections.clear(),this.updateCardSelectionStyles()}updateCardSelectionStyles(){for(const[e,t]of this.cardElements)this.selectedCollections.has(e)?t.classList.add("monomer-collection-card-selected"):t.classList.remove("monomer-collection-card-selected")}async setCurrentObject(){const e=[...this.selectedCollections];if(0===e.length)return;const t=[];for(const n of e){let e=this.collectionsCache.get(n);if(!e)try{e=await this.libHelper.readMonomerCollection(n)}catch{continue}t.push({name:n,displayName:n.replace(/\.json$/i,""),data:e})}1===t.length?o.shell.o=t[0]:t.length>1&&(o.shell.o=t)}showCardContextMenu(e){const t=s.Menu.popup(),n=[...this.selectedCollections];if(n.length<=1&&n.length>0){const e=n[0],i=this.collectionsCache.get(e);if(i){const n={name:e,displayName:e.replace(/\.json$/i,""),data:i};jn.buildContextMenu(t,n,this.handler)}}else if(n.length>1){const e=n.map(e=>{const t=this.collectionsCache.get(e);return t?{name:e,displayName:e.replace(/\.json$/i,""),data:t}:null}).filter(e=>null!==e);e.length>0&&jn.buildMultiContextMenu(t,e,this.handler)}t.show()}getMonomerTooltipSafe(e){if(!this.monomerLib)return null;const t=[He.o.AA,He.o.NUCLEOTIDE,He.o.CHEM,He.o.BLOB];for(const n of t)try{if(this.monomerLib.getWebEditorMonomer(n,e))return this.monomerLib.getTooltip(n,e)}catch(e){}return null}createAddCard(){const e=r.iconFA("plus",()=>{},"");e.style.fontSize="32px",e.style.marginBottom="8px";const t=r.span(["New Collection"]),n=r.div([e,t],{classes:"monomer-collection-add-card-content"}),i=r.div([n],{classes:"monomer-collection-add-card"});return i.addEventListener("click",()=>this.showAddCollectionDialog()),i}showAddCollectionDialog(){const e=r.input.string("Name",{nullable:!1,placeholder:"Enter collection name"}),t=r.input.string("Description",{nullable:!0,placeholder:"Optional description"}),n=r.input.string("Tags",{nullable:!0,placeholder:"Comma-separated tags"}),i=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),s=new qn(this.monomerLib,i.value,[],this.libHelper);i.onChanged.subscribe(()=>{s.setPolymerType(i.value)}),r.dialog({title:"New Monomer Collection"}).add(r.divV([e,t,n,i,r.element("hr"),s.root])).onOK(async()=>{const i=e.value?.trim();if(!i)return void o.shell.warning("Collection name is required");const r=s.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const a=_o(n.value);try{await this.libHelper.addOrUpdateMonomerCollection(i,r,t.value??void 0,a.length>0?a:void 0),o.shell.info(`Collection "${i}" created successfully`),await this.refresh()}catch(e){o.shell.error("Error creating collection"),ys.logger.error(`Error creating collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",s.focus()}editCollectionPublic(e,t){this.showEditCollectionDialog(e,t)}showEditCollectionDialog(e,t){const n=e.replace(/\.json$/i,""),i=r.input.string("Name",{value:n,nullable:!1}),s=r.input.string("Description",{value:t.description??"",nullable:!0}),a=r.input.string("Tags",{value:(t.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new qn(this.monomerLib,l.value,[...t.monomerSymbols??[]],this.libHelper);l.onChanged.subscribe(()=>{c.setPolymerType(l.value)}),r.dialog({title:`Edit Collection: ${n}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const t=i.value?.trim();if(!t)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=_o(a.value);try{t!==n&&await this.libHelper.deleteMonomerCollection(e),await this.libHelper.addOrUpdateMonomerCollection(t,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${t}" saved successfully`),await this.refresh()}catch(e){o.shell.error("Error saving collection"),ys.logger.error(`Error saving collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",c.focus()}confirmDeleteCollection(e){const t=e.replace(/\.json$/i,"");r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete the collection "${t}"?`)).onOK(async()=>{try{await this.libHelper.deleteMonomerCollection(e),o.shell.info(`Collection "${t}" deleted`),await this.refresh()}catch(e){o.shell.error("Error deleting collection"),ys.logger.error(`Error deleting collection: ${e instanceof Error?e.message:e.toString()}`)}}).show()}async refresh(){this.selectedCollections.clear(),await this.loadCollections()}}function _o(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}class Lo{colInput;constructor(e,t){const n=t.filter;this.colInput=r.input.column(e,{...t,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE&&(!n||n(e))});const i=r.iconFA("cut",()=>this.onRegionIconClick(),"Extract a region from the sequence");this.colInput.addOptions(i)}static create(e,t){return new Lo(e,t)}get root(){return this.colInput.root}get value(){return this.colInput.value}set value(e){this.colInput.value=e}get inputBase(){return this.colInput}onRegionIconClick(){const e=this.colInput.value;e?function(e,t){const n=ys.seqHelper.getSeqHandler(e),i=r.input.string("Name",{value:""}),a=r.input.choice("Start Position",{value:n.posList[0],items:n.posList,onValueChanged:()=>h()}),l=r.input.choice("End Position",{value:n.posList[n.posList.length-1],items:n.posList,onValueChanged:()=>h()});let c=null;const u=()=>c?`${e.name}(${c}): ${a.value}-${l.value}`:`${e.name}:${a.value}-${l.value}`,h=()=>{i.value||i.input.setAttribute("placeholder",u())};h();const d=function(e,t,n,i){let o=null;const s=e.getTag(ue.gp.annotations);if(s)try{const e=JSON.parse(s).filter(e=>e.category===xt.eI.Structure&&e.start&&e.end);e.length>0&&(o=e.map(e=>({name:e.name,start:e.start,end:e.end})))}catch{}if(!o){const t=e.getTag(ue.gp.regions);if(t)try{o=JSON.parse(t)}catch{}}if(!o||0===o.length)return null;const a=["",...o.map(e=>`${e.name}: ${e.start}-${e.end}`)];return r.input.choice("Region",{value:"",items:a,onValueChanged:e=>{if(!e)return void i?.(null);const r=o.find(t=>`${t.name}: ${t.start}-${t.end}`===e);r&&(t.value=r.start,n.value=r.end,i?.(r.name))}})}(e,a,l,e=>{c=e,h()}),m=[];d&&m.push(d),m.push(i,a,l);const p=r.dialog({title:"Get Region"}).add(r.inputs(m)).onOK(()=>{const n=s.TaskBarProgressIndicator.create("Getting region...");try{const n=i.value||u(),o=Ei(e,a.value,l.value,n);e.dataFrame.columns.add(o),o.setTag(s.TAGS.CELL_RENDERER,"sequence"),t?.(o)}catch(e){o.shell.error(e.toString())}finally{n.close()}});p.show()}(e,e=>{this.colInput.value=e}):o.shell.warning("Select a macromolecule column first.")}}async function No(){return await vs.getMonomerLibHelper()}async function Po(){await vs.initBio()}function Ro(e){return vs.sequenceTooltip(e)}async function $o(e){return await vs.standardiseMonomerLibrary(e)}async function Oo(e,t,n){await vs.matchWithMonomerLibrary(e,t,n)}function ko(){return vs.getBioLib()}function Ho(e){return vs.getSeqHandler(e)}function Bo(e){return vs.getRegionPanel(e)}async function Fo(e){return await vs.libraryPanel(e)}function Do(e){vs.GetRegionEditor(e)}function Go(e){vs.SplitToMonomersEditor(e)}function Vo(e){vs.SequenceSpaceEditor(e)}function qo(e){vs.SeqActivityCliffsEditor(e)}function jo(){return vs.customSequenceCellRenderer()}function Uo(){return vs.fastaSequenceCellRenderer()}function Wo(){return vs.separatorSequenceCellRenderer()}function zo(){return vs.bilnSequenceCellRenderer()}function Yo(e,t,n){return vs.refineNotationProviderForBiln(e,t,n)}function Ko(e){return vs.macroMolColumnPropertyPanel(e)}function Zo(e){return vs.compositionAnalysisWidget(e)}function Xo(e){return vs.monomerInfoPanel(e)}function Jo(){return vs.macromoleculeDifferenceCellRenderer()}function Qo(e,t,n,i,o){return vs.sequenceAlignment(e,t,n,i,o)}function er(){return vs.webLogoViewer()}function tr(){return vs.vdRegionsViewer()}function nr(e,t,n,i){return vs.getRegion(e,t,n,i)}async function ir(e,t,n,i,o){await vs.getRegionTopMenu(e,t,n,i,o)}function or(){vs.applyNumberingScheme()}function rr(){vs.scanLiabilities()}function sr(){vs.manageAnnotations()}function ar(e,t){return vs.sequenceColumnInput(e,t)}async function lr(e,t,n,i,o,r,s,a,l){return await vs.activityCliffs(e,t,n,i,o,r,s,a,l)}async function cr(e){await vs.seqActivityCliffsInitFunction(e)}async function ur(e,t,n,i,o,r,s,a,l){await vs.seqActivityCliffsTransform(e,t,n,i,o,r,s,a,l)}async function hr(e,t,n,i,o){return await vs.macromoleculePreprocessingFunction(e,t,n,i,o)}async function dr(e,t){return await vs.helmPreprocessingFunction(e,t)}async function mr(e,t,n,i,o,r,s,a,l){return await vs.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function pr(e,t,n,i,o,r,s,a,l){return await vs.sequenceSpaceTransform(e,t,n,i,o,r,s,a,l)}async function gr(e,t){await vs.moleculesToHelmTopMenu(e,t)}async function fr(e){return await vs.moleculeToHelmSingle(e)}async function yr(e,t,n,i){await vs.toAtomicLevel(e,t,n,i)}async function br(e){await vs.toAtomicLevelAction(e)}async function vr(e){return await vs.toAtomicLevelPanel(e)}async function wr(e){return await vs.toAtomicLevelSingleSeq(e)}async function Cr(e){return await vs.sequence3dStructureWidget(e)}function Ar(){vs.multipleSequenceAlignmentDialog()}async function Sr(e,t,n){return await vs.alignSequences(e,t,n)}async function xr(){return await vs.compositionAnalysis()}function Er(e){return vs.importFasta(e)}function Mr(e){return vs.importBam(e)}function Tr(){vs.convertDialog()}function Ir(e){vs.convertColumnAction(e)}function _r(){return vs.monomerCellRenderer()}async function Lr(e){return await vs.testDetectMacromolecule(e)}async function Nr(e,t){return await vs.splitToMonomersTopMenu(e,t)}function Pr(e){return vs.getHelmMonomers(e)}function Rr(){return vs.similaritySearchViewer()}function $r(){return vs.similaritySearchTopMenu()}function Or(){return vs.diversitySearchViewer()}function kr(){return vs.diversitySearchTopMenu()}function Hr(e){vs.searchSubsequenceEditor(e)}function Br(e){vs.SubsequenceSearchTopMenu(e)}async function Fr(e,t,n){return await vs.sequenceIdentityScoring(e,t,n)}async function Dr(e,t,n){return await vs.sequenceSimilarityScoring(e,t,n)}async function Gr(){await vs.manageMonomerLibraries()}async function Vr(){await vs.manageLibrariesView()}async function qr(){await vs.manageMonomersView()}async function jr(e){return await vs.manageMonomerLibrariesView(e)}async function Ur(e){await vs.manageMonomerLibrariesViewTreeBrowser(e)}async function Wr(){return await vs.monomerCollectionsApp()}function zr(){vs.saveAsFasta()}function Yr(){return vs.bioSubstructureFilter()}function Kr(){return vs.bioSubstructureFilterTest()}async function Zr(){await vs.webLogoLargeApp()}async function Xr(){await vs.webLogoAggApp()}async function Jr(){await vs.getRegionApp()}async function Qr(){await vs.getRegionHelmApp()}function es(){vs.longSeqTableSeparator()}function ts(){vs.longSeqTableFasta()}function ns(){vs.longSeqTableHelm()}function is(e,t){vs.addCopyMenu(e,t)}async function os(){await vs.demoBioSimilarityDiversity()}async function rs(){await vs.demoBioSequenceSpace()}async function ss(){await vs.demoBioActivityCliffs()}async function as(){await vs.demoBioAtomicLevel()}async function ls(e){await vs.sdfToJsonLib(e)}async function cs(e,t){return await vs.seq2atomic(e,t)}async function us(e,t){return await vs.seqIdentity(e,t)}async function hs(e,t,n){await vs.detectMacromoleculeProbe(e,t,n)}async function ds(){return await vs.getSeqHelper()}async function ms(e,t,n){return await vs.getMolFromHelm(e,t,n)}!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(xo||(xo={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.monomerInfoPanel=async function(e){return await o.functions.call("Bio:MonomerInfoPanel",{monomerSv:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.applyNumberingScheme=async function(){return await o.functions.call("Bio:ApplyNumberingScheme",{})},e.scanLiabilities=async function(){return await o.functions.call("Bio:ScanLiabilities",{})},e.manageAnnotations=async function(){return await o.functions.call("Bio:ManageAnnotations",{})},e.sequenceColumnInput=async function(e,t){return await o.functions.call("Bio:SequenceColumnInput",{name:e,options:t})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.seqActivityCliffsInitFunction=async function(e){return await o.functions.call("Bio:SeqActivityCliffsInitFunction",{sp:e})},e.seqActivityCliffsTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SeqActivityCliffsTransform",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,options:a,isDemo:l,axesNames:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.sequenceSpaceTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTransform",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,options:s,clusterEmbeddings:a,embedColsNames:l,clusterColName:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesView",{path:e})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.monomerCollectionsApp=async function(){return await o.functions.call("Bio:MonomerCollectionsApp",{})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(Eo||(Eo={}));var ps=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},gs=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},fs=function(e,t){return function(n,i){t(n,i,e)}};const ys=new vi;let bs=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class vs{static async getMonomerLibHelper(){return await yn.getInstance()}static async initBio(){null==bs&&(bs=async function(){const e="Bio: _package.initBio()";ys.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Le.j)(),i=await ys.getProperties(),r=new bi(i);ys.properties=r;const a=await yn.getInstance(),l=await(0,_e.u)();l.explicit&&(l.explicit=[],await(0,_e.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();ys.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new no(a,n);ys.completeInit(m,u,h,n),s.ObjectHandler.register(new jn),ys.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[Co]||(t.temp[Co]=[]);let i=t.temp[Co];i.forEach(e=>e.unsubscribe()),t.temp[Co]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[wo];i.temp[wo]=!0;let l=null;try{l=ys.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>Re.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],v=l.splitter(b),w=v?v.length:30,C=e.getTag(ue.gp.annotations)?24:0,A={WITH_TITLE:58,WITH_WEBLOGO:107+C,WITH_BOTH:156+C};let S;S=e.length>1e5||w<50?A.WITH_TITLE+C:e.length>5e4?A.WITH_WEBLOGO:A.WITH_BOTH;let x=null,E=null;const M=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{yo.clearAllCaches(),x&&(x.resetViewportTracking(),x.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(M);const T=o=>{const c=[],h=new fo(e,"Annotations");h.hasRegions()&&c.push({id:"annotations",track:h,priority:0});const g=new bo(l,w,45,"WebLogo");x=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:1});const f=new vo(l,w,45,"default","Conservation");E=f,c.push({id:"conservation",track:f,priority:2});const y=new po({canvas:t.overlay,headerHeight:S,totalPositions:w+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<A.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);y.setupTooltipHandling(),c.sort((e,t)=>e.priority-t.priority),c.forEach(({id:e,track:t})=>{y.addTrack(e,t)}),y.setSelectionData(n,e,l),w>50&&!a&&(t.props.colHeaderHeight=S,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>y.detach()});const b=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==b?.dart)return;const i=t.bounds;if(!i)return;y.headerHeight=i.height;const o=p();y.positionWidth=o+8;const r=d();y.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();T(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await bs}static sequenceTooltip(e){const t=new Si(e,ys.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Mn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await Mn(l);c.forEach((e,t)=>{e.lib=l[t].lib});const{cappedMap:u,uncappedMap:h}=await async function(e,t,n){const i={};for(const t of e){if(!t.smiles)continue;const e={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source??""};i[t.smiles]||(i[t.smiles]=[]),i[t.smiles].push(e)}const o=e.map((e,n)=>({symbol:e.symbol,smiles:Hn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:t[n]?.lib?.source??""})).filter(e=>!!e.smiles&&!e.smiles.includes("[*:")),r=s.Column.fromList(s.COLUMN_TYPE.STRING,"CappedSmiles",o.map(e=>e.smiles));r.semType=s.SEMTYPE.MOLECULE;const a=await n.apply({molecule:r,targetNotation:s.chem.Notation.Smiles});if(!a||a.length!==r.length)throw new Error("Error canonicalizing capped monomer SMILES");const l={},c=a.toList();for(let e=0;e<c.length;e++){const t=c[e];if(!t)continue;o[e].smiles=t;const n=o[e];l[t]||(l[t]=[]),l[t].push(n)}return{cappedMap:l,uncappedMap:i}}(c,l,a),d=await async function(e,t,n){const i=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return On([],t?void 0:e,t?e:void 0)}catch(t){return e}}),o=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesCorrected",i);o.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([o]);const r=await n.apply({molecule:o,targetNotation:s.chem.Notation.Smiles});if(!r||r.length!==o.length)throw new Error("Error canonicalizing molecules");return r.toList()}(e,t,a),m=new Array(d.length).fill(null).map(()=>[]),p=[];for(let e=0;e<d.length;e++){const t=d[e];if(!t)continue;const n=Cn(t,u,h);n.length>0?m[e]=n:p.push(e)}if(p.length>0)try{const{fpMap:e}=await async function(e){const t=Object.keys(e);if(0===t.length)return{fpMap:{},cappedSmilesList:[]};const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",t);n.semType=s.SEMTYPE.MOLECULE;const i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r={};for(let n=0;n<i.length;n++){const o=i.get(n);if(!o)continue;const s=o.toBinaryString(),a=e[t[n]]??[];r[s]||(r[s]=[]),r[s].push(...a)}return{fpMap:r,cappedSmilesList:t}}(u),t=await async function(e,t,n){const i=new Map;if(0===e.length||0===Object.keys(n).length)return i;const r=e.map(e=>t[e]??""),a=r.map(e=>{if(!e)return"";const t=Hn(e,wn);return t!==e?o.chem.convert(t,s.chem.Notation.Unknown,s.chem.Notation.Smiles):e}),l=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMols",r);l.semType=s.SEMTYPE.MOLECULE;const c=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMolsCapped",a);c.semType=s.SEMTYPE.MOLECULE;const[u,h]=await Promise.all([o.functions.call("Chem:getMorganFingerprints",{molColumn:l}),o.functions.call("Chem:getMorganFingerprints",{molColumn:c})]);for(let t=0;t<e.length;t++){const o=e[t],r=u.get(t);if(r){const e=n[r.toBinaryString()];if(e&&e.length>0){i.set(o,e);continue}}const s=h.get(t);if(s){const e=n[s.toBinaryString()];e&&e.length>0&&i.set(o,e)}}return i}(p,d,e);for(const[e,n]of t)m[e]=n}catch(e){console.warn("Fingerprint fallback matching failed, continuing with SMILES matches only:",e)}const g=e.clone(),f=g.columns.addNewString(g.columns.getUnusedName("Matched monomer symbol")),y=g.columns.addNewString(g.columns.getUnusedName("Matched monomer smiles"));y.semType=s.SEMTYPE.MOLECULE;const b=g.columns.addNewString(g.columns.getUnusedName("Matched monomer source")),v=g.columns.addNewInt(g.columns.getUnusedName("Match count")),w=g.columns.addNewString(g.columns.getUnusedName("Match method"));g.columns.setOrder([t,f.name,y.name,b.name,v.name,w.name]);for(let e=0;e<m.length;e++){const t=m[e];if(0===t.length)continue;const n=An(t),i=Sn(n,r);f.set(e,n.map(e=>e.symbol).join(" | "),!1),y.set(e,n[0].original??n[0].smiles,!1),b.set(e,i,!1),v.set(e,n.length,!1);const o=p.includes(e)?"fingerprint":"exact";w.set(e,o,!1)}return g}(e,t.name,ys.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return ys.monomerLib}static getSeqHandler(e){return ys.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:ys.name,name:t});if(1!==n.length)throw new Error(`Package '${ys.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new Ii(i,ys.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Wn()(e).addClass("d4-link-action"),e.onclick=async()=>await Jn(),new s.Widget(e)}()}static GetRegionEditor(e){try{new Ii(e,ys.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),ys.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new di;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new P({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Ce({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new je}static fastaSequenceCellRenderer(){return new je}static separatorSequenceCellRenderer(){return new je}static bilnSequenceCellRenderer(){return new je}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[me.j.notationProvider]=new Ao(n,ys.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let i=ys.properties?ys.properties.maxMonomerLength:4;if(Pe.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Pe.gp.maxMonomerLength));i=isNaN(t)?i:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);i=isNaN(t)?i:t}const o=r.input.int("Max Monomer Length",{value:i,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{o.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let a=ys.properties?ys.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(a=e.temp[".mm.cellRenderer.fontSize"]);const l=r.input.int("Font Size",{value:a,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),c=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),u=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),d=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let m=null;e.meta.units!==ue.Hi.HELM&&(m=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[l,o,c,h,u,d];m&&p.push(m);const g=r.inputs(p),f=(0,St.Ln)(e),y=r.divV([]);if(f.length>0){const t=e.getTag(ue.gp.numberingScheme),i=f.filter(e=>e.category===xt.eI.Structure),o=f.filter(e=>e.category===xt.eI.Liability);if(t&&y.append(r.divText(`Numbering: ${t}`,{style:{fontSize:"12px",marginBottom:"4px"}})),i.length>0){const e=i.map(e=>e.name).join(", ");y.append(r.divText(`Regions: ${e}`,{style:{fontSize:"12px",marginBottom:"4px"}}))}if(o.length>0){const e=o.reduce((e,t)=>{const n=t.description?.match(/\((\d+) hits\)/);return e+(n?parseInt(n[1]):0)},0);y.append(r.divText(`Liabilities: ${o.length} rules (${e} hits)`,{style:{fontSize:"12px",marginBottom:"4px"}}))}const s=r.button("Manage",()=>{n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}),a=r.button("Clear All",()=>{(0,St.OW)(e.dataFrame,e),e.dataFrame.fireValuesChanged()});y.append(r.divH([s,a],{style:{gap:"4px",marginTop:"4px"}}))}else{y.append(r.divText("No annotations",{style:{fontSize:"12px",color:"#888"}}));const e=r.button("Scan Liabilities",()=>{n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}),t=r.button("Apply Numbering",()=>{n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())});y.append(r.divH([e,t],{style:{gap:"4px",marginTop:"4px"}}))}const b=r.accordion();return b.addPane("Renderer Settings",()=>g),b.addPane("Annotations",()=>y),new s.Widget(b.root)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?He.o.NUCLEOTIDE:He.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===He.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,$e.MD)(n)}});const m=(0,wi.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,ys.monomerLib,ys.seqHelper)}static monomerInfoPanel(e){return function(e,t){const n=function(e,t){return e.getMonomer(null,t)}(t,e);if(!n)return new s.Widget(r.divText(`Monomer '${e}' not found in the library.`));const i=r.accordion("Monomer");return i.addPane("Details",()=>{const e={Symbol:n.symbol,Name:n.name,"Polymer Type":n.polymerType,"Monomer Type":n.monomerType};if(n.author&&(e.Author=n.author),n.naturalAnalog&&(e["Natural Analog"]=n.naturalAnalog),n.lib?.source){let t=n.lib.source;t.endsWith(".json")&&(t=t.substring(0,t.length-5)),e.Library=t}n.molfile?e.Structure=o.chem.drawMolecule(n.molfile,150,150):n.smiles&&(e.Structure=o.chem.drawMolecule(n.smiles,150,150));const t=n.rgroups;if(t&&t.length>0)for(const n of t)e[n.label??"?"]=n.alternateId??"";return r.tableFromMap(e)},!0),i.addPane("Molecule",()=>{const e=function(e){try{return Hn(On(e.rgroups,e.smiles,e.molfile),e.rgroups)}catch{}return null}(n);if(!e)return r.divText("No molecular structure available");const t=s.SemanticValue.fromValueType(e,s.SEMTYPE.MOLECULE);return r.panels.infoPanel(t).root},!0),new s.Widget(i.root)}(e.value,ys.monomerLib)}static macromoleculeDifferenceCellRenderer(){return new We}static sequenceAlignment(e,t,n,i,o){const r=new lt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new et.oP}static vdRegionsViewer(){return new rt}static getRegion(e,t,n,i){return Ei(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=Ei(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static applyNumberingScheme(){n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())}static scanLiabilities(){n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}static manageAnnotations(){n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}static sequenceColumnInput(e,t){return Lo.create(e,t)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,li.V)(t,"Activity Cliffs"))return;const p=c===l.c.UMAP?2e5:2e4,g=c===l.c.UMAP?5e3:2e3;if(e.rowCount>p)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${p}`);const f=Ee(e),y=async()=>{await s.Func.find({name:"seqActivityCliffsTransform"})[0].prepare({table:e,molecules:t,activities:n,similarity:i,methodName:c,similarityMetric:u,options:JSON.stringify(d),isDemo:m,axesNames:f}).call(void 0,void 0,{processed:!1});const r=o.shell.tv,a=`Molecules: ${t.name}, activities: ${n.name}, method: ${c}, ${d?`options: ${JSON.stringify(d)},`:""} similarity: ${u}, similarity cutoff: ${i}`;r.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:f[0],yColumnName:f[1],color:n.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:"Activity cliffs",initializationFunction:"seqActivityCliffsInitFunction",description:a,descriptionVisibilityMode:"Never"})},b=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");try{e.rowCount>g&&!d?.[a.vb]?await new Promise((e,t)=>{r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{y().then(()=>e()).catch(e=>t(e))}).onCancel(()=>{e()}).show()}):await y()}catch(e){const[t,n]=(0,ve.AP)(e);throw ys.logger.error(t,void 0,n),e}finally{b.close()}}static async seqActivityCliffsInitFunction(e){const t=e.dataFrame.getTag("seqActivityCliffsParams");if(!t)return void o.shell.error("Sequence activity cliffs parameters not found in table tags");const n=JSON.parse(t),i=e.dataFrame.col(n.seqColName),r=e.dataFrame.col(n.activityColName),a=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],l=await a.apply({col:i,metric:n.similarityMetric}),c=[e.getOptions().look.xColumnName,e.getOptions().look.yColumnName],u={units:i.meta.units,aligned:i.getTag(ue.gp.aligned),separator:i.getTag(ue.gp.separator),alphabet:i.getTag(ue.gp.alphabet)};await le(e,e.dataFrame,i,l,r,c,n.similarity,n.similarityMetric,n.options??{},s.SEMTYPE.MACROMOLECULE,u,ht,dt,ft,void 0,n.isDemo)}static async seqActivityCliffsTransform(e,t,i,o,r,a,l,c,u){await e.meta.detectSemanticTypes();const h=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];u||(u=Ee(e)),await async function(e,t,i,o,r,s,a,l){const c=l.inputs,u=await l.apply({[c[0].name]:t,[c[1].name]:r,...a.preprocessingFuncArgs??{}});let h=[];if(s===L){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([u.entries],o,[1],"MANHATTAN",[r],[u.options??{}],a?.maxIterations??5,a.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),h=[t.embedX,t.embedY]}else h=await U([u.entries],s,[r],[1],"MANHATTAN",{...a,distanceFnArgs:[u.options??{}]});if(h.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<h.length;++t)e.columns.addNewFloat(i[t]).init(e=>h[t][e])}(e,t,u,o,a,r,JSON.parse(l??"{}"),h);const d={seqColName:t.name,activityColName:i.name,similarityMetric:a,similarity:o,options:l??{},isDemo:c};e.setTag("seqActivityCliffsParams",JSON.stringify(d))}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ct(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ut.BQ)(e,ys.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=D.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,a,l,c,u){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,li.V)(t,"Sequence Space"))return;const h=e.columns.getUnusedName("Cluster (DBSCAN)"),d=Ee(e);let m;if(await s.Func.find({name:"sequenceSpaceTransform"})[0].prepare({table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:!1,options:JSON.stringify(l),clusterEmbeddings:c,embedColsNames:d,clusterColName:h}).call(void 0,void 0,{processed:!1}),r){m=o.shell.tv.scatterPlot({x:d[0],y:d[1],title:"Sequence space"});const e=`Molecules column: ${t.name}, method: ${n}, ${l?`options: ${JSON.stringify(l)},`:""} similarity: ${i}`;m.setOptions({description:e,descriptionVisibilityMode:"Never"}),c&&(m.props.colorColumnName=h)}return m}static async sequenceSpaceTransform(e,t,n,i,r,l,c,u,h){await e.meta.detectSemanticTypes();const d=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],m=JSON.parse(l??"{}"),p=o.shell.tv?.dataFrame==e?o.shell.tv:void 0;return await Te(e,[t],n,[i],[1],[d],"MANHATTAN",r,c??!1,{...m,preprocessingFuncArgs:[m.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:m?.[a.vb],tableView:p,embedColsNames:u,clusterColName:h})}static async moleculesToHelmTopMenu(e,t){const n=ys.monomerLib,i=JSON.stringify(n.toJSON());await xo.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=ue.Hi.HELM,o.semType=s.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await vs.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await bs;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??ys.monomerLib,r=ys.seqHelper,s=ys.rdKitModule;await(0,_i.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await io(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){ys.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await io(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await io(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=Ri.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,ui.D)({},ys.seqHelper).catch(e=>{const[t,n]=(0,ve.AP)(e);if(e instanceof ci.Ap)return o.shell.warning(e.element),void ys.logger.warning(t);o.shell.error(t),ys.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,ui.D)({col:e,clustersCol:t,...n},ys.seqHelper)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(ys.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,li.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>ys.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Ne.me)()[0];(0,At.C)(e,ys.seqHelper)}static convertColumnAction(e){(0,At.C)(e,ys.seqHelper)}static monomerCellRenderer(){return new fi}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await s.delay(10),!(0,li.V)(t,"Sequence space"))return e;const n=ge(t,ys.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ge.uF.MONOMER,e.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ge.uF.MONOMER,o.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return ys.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new wt(ys.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Ct(ys.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Ne.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,ys.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=ys.seqHelper;return Li(e,t,n,fe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=ys.seqHelper;return Li(e,t,n,fe.SIMILARITY,i)}static async manageMonomerLibraries(){Jn()}static async manageLibrariesView(){await Qn()}static async manageMonomersView(){const e=await In.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(e){const t=await Qn(!1);return t.parentCall=o.functions.getCurrentCall(),t}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await yn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await In.getInstance();(await e.getViewRoot(t,!0)).parentCall=o.functions.getCurrentCall(),e.resetCurrentRowFollowing()})})}static async monomerCollectionsApp(){return await async function(e=!0){if(e){const e=Array.from(o.shell.views).find(e=>e.name===Io.VIEW_NAME);if(e)return o.shell.v=e,e}const t=new Io,n=await t.init();return e&&o.shell.addView(n),n}(!1)}static saveAsFasta(){(0,Dn.TE)()}static bioSubstructureFilter(){return new Gn._i(ys.seqHelper,ys.logger)}static bioSubstructureFilterTest(){return new Gn._i(ys.seqHelper,ys.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new hi(e,"webLogoLargeApp"),n=await ys.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new hi(e,"webLogoAggApp"),n=await ys.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Ti(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await ys.files.readCsv("samples/HELM_empty_vals.csv"),n=new Ti(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,Ie.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(ys.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(ys.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,i){const r=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(r,t=>{const n=e.column,r=e.rowIndex,s=i.getSeqHandler(n),a=t===ue.Hi.SEPARATOR?ys.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")});const s=e.column,a=(0,St.Ln)(s);if(a.length>0&&new xi.$(s).hasAnnotations()){const e=a.filter(e=>e.category===xt.eI.Structure);if(e.length>0){const r=t.group("Annotations");for(const t of e)t.start&&t.end&&r.item(`Extract ${t.name} as Column`,()=>{n.e(288).then(n.bind(n,9288)).then(e=>{try{e.extractAnnotatedRegion(s.dataFrame,s,t.name,i)}catch(e){o.shell.error(`Failed to extract region: ${e.message??e}`)}})});a.filter(e=>e.category===xt.eI.Liability).length>0&&r.item("Filter: Rows with Liability Hits",()=>{n.e(288).then(n.bind(n,9288)).then(e=>{e.filterByLiabilityHits(s.dataFrame,s)})})}}}(e,t,ys.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await ys.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Ne.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await ys.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await vs.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Wn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),ys.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await ys.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await vs.toAtomicLevel(e,n,!0,!1),(0,Ne.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Ne.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?vs.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await Li(i,n,t,fe.IDENTITY,ys.seqHelper)).get(0)}catch(e){const[t,n]=(0,ve.AP)(e);throw ys.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await s.delay(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await vs.initBio(),ys.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=ys.seqHelper,r=(await 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c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,p,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}(0,s.aZ)(C,b);const A=new Array(y).fill(null);for(const e of w){if(!e||0===e.length)continue;const t=(await m(f.id,e,i,l,u,p)).Alignment;for(const e of t)A[parseInt(e.ID)]=Object.entries(e).filter(e=>!h.includes(e[0])).map(e=>"-"!==e[1]?e[1]:"").join(a.J.SEPARATOR)}const S=o.Column.fromStrings(n,A);return S.meta.units=r.Hi.SEPARATOR,S.setTag(r.gp.separator,a.J.SEPARATOR),S.setTag(r.gp.aligned,"SEQ.MSA"),S.setTag(r.gp.alphabet,r.YI.UN),S.setTag(r.gp.alphabetIsMultichar,"true"),S.semType=o.SEMTYPE.MACROMOLECULE,S}async function m(e,t,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok&&m){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!m){const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();if("pepsea-stderr"in p){const e=p["pepsea-stderr"];s?.warning(e)}return p}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(980);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=u(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{n5:()=>C,oP:()=>_});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(980);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,A=n(6307),S=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class x{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class E{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,S.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,A.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var T;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(T||(T={}));const I=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(T.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,I.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new E(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=T.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(T.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687(e,t,n){"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),v=n(980);class w extends m.O{seqHelper;emptyProps=new m.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await o.delay(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await o.delay(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends m.O{emptyProps=new m.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new S(this.props.substructure,t,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use 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n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=r(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const h=Array.from({length:127},(e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function m(e,t){const n=Object.assign({},t),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const e=o(r.host);if(!1===e.isIPV4){const t=i(e.host);r.host=t.host.toLowerCase(),a=t.isIPV6}else r.host=e.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&r.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(e){r.error=r.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),e&&e.parse&&e.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const p={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(m(e,t),t):"object"==typeof e&&(e=m(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(m(e,i),m(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(m(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(m(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:m};e.exports=p,e.exports.default=p,e.exports.fastUri=p},343(e){"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function r(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const o=`${n}:${t.nid||e.nid}`,r=l[o];e.path=void 0,r&&(e=r.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),o=`${n}:${t.nid||i}`,r=l[o];r&&(e=r.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914(e){"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834(e,t,n){"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(o)||[],[n]=t;return 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t=[];for(;e.length;)if(e.match(u))e=e.replace(u,"");else if(e.match(h))e=e.replace(h,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(m);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837(e){"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216(e){"use 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0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function me(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new he;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function pe(e,t,n){var 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A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new G("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new G('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new G("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new G("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new G("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new G("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new q("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var m=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,m&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,m&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Ee(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new q("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new G("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new G("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new q("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new q("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new q("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;p||(p=Se(e,r,{}),v=!0,r===s&&(g=p,w=!0)),g||(g=Se(e,s,{}),w=!0),d=new z(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new G("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new G('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new G("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?W:U;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new G("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new G("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new q("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new q("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new G('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new q('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new G('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new G('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new q("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new q("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new G("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new G("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new G("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new G("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new G("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new G("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new G("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new G("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new G("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new G("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new G("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new G("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new G("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new G("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new G("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new G("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new G("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new G("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new G("Graph.import: invalid edges. 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}var R=n(9713),$=n(6295);const O=e=>null==e;function k(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class H{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,g=Number.MIN_VALUE;for(let 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l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let m=0;const p=(a+1)/n;for(let e=0;e<o;e++)r[e]<p&&(l[m]=h[e],c[m]=d[e],u[m]=r[e],m++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)k(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)k(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,D=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class G{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new D.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,t),r=this.getPointOnDistance(S,x,w,C,n,t);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new D.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var q,j=n(3629);async function W(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,j.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(q||(q={}));const U={[q.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[q.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var z;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(z||(z={}));const Y={[z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[z.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},K={[z.HAMMING]:e=>Math.ceil(e/30),[z.EUCLIDEAN]:e=>Math.ceil(e/30),[z.MANHATTAN]:e=>Math.ceil(e/30),[z.TANIMOTO]:e=>Math.ceil(e/30),[z.SOKAL]:e=>Math.ceil(e/30),[z.COSINE]:e=>Math.ceil(e/30),[z.ASYMMETRIC]:e=>Math.ceil(e/30),[z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[z.Difference]:e=>1,[z.OneHot]:e=>Math.ceil(e/40),[z.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([z.HAMMING,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.MONOMER_CHEMICAL_DISTANCE,z.OneHot]),UINT32ARRAY:new Set([z.HAMMING,z.EUCLIDEAN,z.MANHATTAN,z.MONOMER_CHEMICAL_DISTANCE,z.LEVENSTEIN,z.NEEDLEMAN_WUNSCH,z.TANIMOTO,z.COSINE,z.VECTOR_COSINE,z.SOKAL,z.ASYMMETRIC,z.OneHot,z.Difference]),INT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.OneHot,z.Difference,z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference,z.VECTOR_COSINE]),NUMBER:new Set([z.EUCLIDEAN,z.MANHATTAN,z.Difference]),BITARRAY:new Set([z.TANIMOTO,z.COSINE,z.SOKAL,z.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return x(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device 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instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=K[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===z.NEEDLEMAN_WUNSCH||t===z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/f),T=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${J(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),_=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(A/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?A-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);_[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),H=h.reduce((e,t)=>e+t.suppInfoSize,0),B=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let D=F;const G=15&F;0!==G&&(D+=16-G);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,f).set(_),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(L),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(N),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(P),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g.length).set(g),W+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,W,c).set(o),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,W,n).set(e.flatSourceArray),W+=n*t.BYTES_PER_ELEMENT}V.unmap();const U=H*Uint32Array.BYTES_PER_ELEMENT;let Y=U;const X=15&U;0!==X&&(Y+=16-X),Y=Math.max(Y,16);const Q=s.createBuffer({label:"supp info buffer",size:Y,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,B);o+=B*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),Q.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function J(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${Y[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${U[i](e.length)}\n }\n \n `}var Q=n(1991),ee=n.n(Q);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,n,i,a,l,c,u,h,d,m,p,g,f,y,b){te++;const v=c/100;let w,C=!1;const A=o.shell.tv?.dataFrame===t?o.shell.tv:o.shell.getTableView(t.name);let S=null;if(h.useWebGPU)try{S=await X([i.entries],v,[u],q.MANHATTAN,[1],[i.options??{}])}catch(e){console.error(e)}S||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),S=await(new B).calc(i.entries,u,v,i.options));const x=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,a=s.BitSet.create(t.length);return e.distance.forEach((t,n)=>{a.set(e.i[n],!0),a.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:a}}(S,a),E=`sali_${l[0].substring(l[0].lastIndexOf("_"))}`;if(!t.columns.names().includes(E)){const i=function(e,t,n,i,o,r,a){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(a.get(i[e])>a.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return s.Column.fromList("double",t,l)}(n.length,E,x.saliVals,x.n1,x.n2,0,a);t.columns.add(i),e.setOptions({size:i.name})}const M=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(x.saliVals),T=.8/(M.max-M.min),I=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(t,x,n,a,d,m,M,T);I.lines.skipMultiLineCalculation=!0,I.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const _=new G(e,l[0],l[1],I.lines,F.none);let L=null;const N=r.button(`${I.linesDf.rowCount} cliffs`,()=>{if(!L?.dataFrame){L=(()=>{const e=f?f(I.linesDf,se).sort([oe],[!1]):I.linesDf.plot.grid().sort([oe],[!1]);return e.col(re)&&(e.col(re).visible=!1),t.temp[".cliffsDfGrid"]=L,e})();const e=ee()(A.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);b&&!e&&A.addViewer(L),A.dockManager.dock(L,"down",void 0,"Activity cliffs",y??.2)}});N.classList.add("scatter_plot_link","cliffs_grid");const P=r.input.toggle("Show only cliffs",{value:!1,onValueChanged:n=>{n?(e.dataFrame.setTag(ae,l[0]),t.filter.and(x.cliffsBitSet),ie.next(l[0])):(e.dataFrame.setTag(ae,""),t.filter.setAll(!0),ie.next(""))}});e.root.prepend(r.divH([N,P.root],"cliffs_div")),ie.subscribe(e=>{P.enabled=""===e||e===l[0]}),t.onRowsFiltering.subscribe(()=>{P.value&&t.filter.and(x.cliffsBitSet)});const $=o.events.onViewerClosed.subscribe(t=>{t.args.viewer===e&&(L&&A.dockManager.close(L.root),$.unsubscribe(),A.subs=A.subs.filter(e=>e!==$))});A.subs.push($),I.linesDf.onCurrentCellChanged.subscribe(()=>{for(let e=0;e<I.linesDf.rowCount;e++)I.lines.widths[e]=e===I.linesDf.currentRowIdx?3:1;_.linesToRender=I.lines;const i=I.linesDf.currentCol&&I.linesDf.currentCol.name===se[1]?I.lines.to:I.lines.from,s=-1!==I.linesDf.currentRowIdx?I.linesDf.currentRowIdx:null;if(e.dataFrame.currentRowIdx=s?i[s]:-1,null!==s){const i=I.linesDf.currentRowIdx;_.currentLineId=i;const{zoomLeft:c,zoomRight:u,zoomTop:h,zoomBottom:d}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<o?n:o)+s/2-h/2,p=(i>r?i:r)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(e.viewport.width,e.viewport.height,e.dataFrame.get(l[0],I.lines.from[i]),e.dataFrame.get(l[1],I.lines.from[i]),e.dataFrame.get(l[0],I.lines.to[i]),e.dataFrame.get(l[1],I.lines.to[i]));e.zoom(c,h,u,d),P.value?t.filter.and(x.cliffsBitSet):!0===P.enabled&&t.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,s,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:s,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout(()=>{o.shell.o=t.root},500)}(t,w,I.lines.from[s],I.lines.to[s],s,n,a,I.linesDf.get(oe,s),g);const i=e.dataFrame.getSortedOrder(A.grid.sortByColumns,A.grid.sortTypes);A.grid.scrollToCell(n.name,i.indexOf(e.dataFrame.currentRowIdx))},1e3)}}),I.linesDf.onSelectionChanged.subscribe(e=>{setTimeout(()=>(()=>{const e=s.BitSet.create(t.rowCount);for(let t=0;t<I.linesDf.rowCount;t++){const n=I.linesDf.selection.get(t);n&&(e.set(I.lines.from[t],!0),e.set(I.lines.to[t],!0)),I.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),_.linesToRender=I.lines})(),100)}),t.onSelectionChanged.subscribe(e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(!C&&L?.dataFrame?(e=>{e.selection.setAll(!1);for(let e=0;e<I.lines.colors.length;e++)I.lines.colors[e]="0,128,0";_.linesToRender=I.lines})(L.dataFrame):C=!1)}),_.lineClicked.subscribe(e=>{if(C=!0,_.currentLineId=e.id,-1!==e.id){const n=I.linesDf.selection.clone();setTimeout(()=>{if(e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),I.linesDf.selection.copyFrom(n)):(I.linesDf.currentRowIdx!==e.id&&(I.linesDf.currentRowIdx=e.id,t.currentRowIdx=I.lines.from[e.id]),I.linesDf.selection.copyFrom(n)),L?.dataFrame){const t=I.linesDf.getSortedOrder(L.sortByColumns,L.sortTypes);L.scrollToCell(se[0],t.indexOf(e.id))}},500)}}),_.lineHover.pipe((0,R.debounceTime)(500)).subscribe(e=>{-1!==e.id&&-1===t.mouseOverRowIdx&&r.tooltip.show(p({lineId:e.id,points:[I.lines.from[e.id],I.lines.to[e.id]],df:t,seqCol:n,activityCol:a}),e.x,e.y)}),e.addProperty("similarityLimit","double",v),w=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}()}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151),me=n(4025),pe=n(439);function ge(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getOriginal(o);(n(o)||i(o)).set(e,r,!1)}}const c=e.temp[me.j.notationProvider]??null,u=c?.monomerCanonicalizerFuncName;if(u)for(const e of o)e.setTag(pe.jz,u);return a}var fe,ye=n(4971);async function be(e){const t=(await(0,ye.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var ve=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ce extends P{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[L]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,Se,xe;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Me(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Te(e,t,i,l,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==l.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=s.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=g.embedColsNames??Ee(e);function x(n,o,l){let c=null,u=null;e.columns.names().includes(S[0])?(c=e.columns.byName(S[0]),u=e.columns.byName(S[1])):(c=e.columns.add(s.Column.float(S[0],e.rowCount)),u=e.columns.add(s.Column.float(S[1],e.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}))),g[a.YP]&&(A?.root&&r.setUpdateIndicator(A.root,!1),c.init(e=>l[0]?l[0][e]:void 0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function E(){e.columns.add(s.Column.float(S[0],e.rowCount)),e.columns.add(s.Column.float(S[1],e.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:g.scatterPlotName??Me(t,i)}),r.setUpdateIndicator(A.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await W(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:x))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await E();if(m&&M){const T=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),_=g.clusterColName??e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(_).init(e=>I[e].toString()),A&&(A.props.colorColumnName=_)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(M){const N=e.columns.byName(S[0]),P=e.columns.byName(S[1]);if(N.init(e=>M[0][e]),P.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return r.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&r.setUpdateIndicator(A.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Se||(Se={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(xe||(xe={})),Object.prototype.toString;var Ie=n(6873),_e=n(4356),Le=n(6717),Ne=n(4870),Pe=n(3856),Re=n(6882),$e=n(7278),Oe=n(5553),ke=n(6642),He=n(3599),Be=n(673),Fe=n(8312);class De extends ke.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,vs.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,Fe.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ge=n(4139);const Ve=ue.zS;function qe(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class je extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=vs.seqHelper}getRendererBack(e){const[t,n,i]=(0,ke.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Oe.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,ke.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(vs.properties?vs.properties.maxMonomerLength:4)??50;if(Pe.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Pe.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new Re.Jy(a,l,vs.logger,d,()=>{const{font:e,fontWidth:t}=Re.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:Ve}}),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class We extends De{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator];let h=this.tableCol.meta.units;i=(0,Re.U0)(l,e,t,i,a);const[d,m]=c.split("#");h!==ue.Hi.CUSTOM||this.tableCol.temp[me.j.notationProvider]||(h=ue.Hi.SEPARATOR);const p=this.tableCol.temp[me.j.notationProvider]?.separatorSplitter??this.tableCol.temp[me.j.notationProvider]?.splitter??(0,$e.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getOriginal(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getOriginal(e)).toArray(),v=this.tableCol.getTag(ue.gp.alphabet);ze(e,t,n,i,o,y,b,v===ue.YI.RNA||v===ue.YI.DNA?He.o.NUCLEOTIDE:He.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new We(t,n)),o}}class Ue extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ge.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){We.getOrCreate(r).render(e,t,n,i,o,r,s)}}function ze(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(pe.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(qe(r).join("")),d=e.measureText(qe(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Re.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Re.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Pe.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Pe.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ye(n,c,d,r,g,h,o))}else p=(0,Pe.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ye(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(qe([e]).join("")).width,u=l.measureText(qe([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Pe.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Pe.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Ke,Ze=n(8070),Xe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Ke||(Ke={}));const Je=new class{constructor(){this.regionTypes=[Ke.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Xe.fH.Entropy,this.filterSource=Xe.Fo.filterSource}};var Qe=n(7602),et=n(250);const tt=Ke;var nt,it;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(nt||(nt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(it||(it={}));const ot=Je;class rt extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(it.skipEmptyPositions,ot.skipEmptyPositions,{category:nt.DATA}),this.regionTypes=this.stringList(it.regionTypes,ot.regionTypes,{category:nt.DATA,choices:Object.values(tt).filter(e=>e!=tt.Unknown)}),this.chains=this.stringList(it.chains,ot.chains,{category:nt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(it.fitWidth,ot.fitWidth,{category:nt.LAYOUT}),this.positionWidth=this.float(it.positionWidth,ot.positionWidth,{category:nt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(it.positionHeight,ot.positionHeight,{category:nt.LAYOUT,choices:Object.keys(Xe.fH)}),this.filterSource=this.string(it.filterSource,ot.filterSource,{category:nt.BEHAVIOR,choices:Object.values(Xe.lT)}),this.viewSyncer=new Qe.g(vs.logger)}static viewerCounter=-1;viewerId=++rt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case it.regionTypes:case it.chains:this.setData(this.regions)}switch(e.name){case it.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case it.fitWidth:case it.positionWidth:this.calcSize();break;case it.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionHeight]:this.positionHeight});this.calcSize();break;case it.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;vs.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){vs.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){vs.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);r&&i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Xe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),vs.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){vs.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[et.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(it.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[et.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Ze.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class st{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class at{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new at(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ct(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=vs.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,ye.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await be(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await be(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ut=n(4954);function ht(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function dt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=vs.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=pt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function pt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=vs.monomerLib;return ze(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function gt(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function ft(e,t){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class yt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class bt extends yt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const vt={gapPenalty:1,matchScore:1,gapSymbol:pe.b9[pe.Hi.FASTA],localAlignment:!1};class wt extends bt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Ne.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Ne.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ct(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new B).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...vt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new $e.Mu(d,i.gapSymbol),seq2Splitted:new $e.Mu(m,i.gapSymbol)}}(c,u),d=pt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class Ct extends bt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Ne.Kd)(i,t.name,450,30),(0,Ne.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ct(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new H(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var At=n(5433),St=n(3736),xt=n(4517);class Et{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Mt={A:new D.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new D.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new D.A(new 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Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new D.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new D.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new D.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new D.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new D.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new D.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new D.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new D.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},Tt={RNA:{A:new D.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new D.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new D.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new D.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new D.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:Mt};async function It(e,t,n=0){if(!Object.keys(Tt).includes(t))return null;const i=await async function(e){const t=s.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new D.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Tt[t])return null;const o=Tt[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var _t;!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(_t||(_t={}));class Lt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Nt extends Lt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends Nt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(_t.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(_t.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(_t.TYPE)&&-1!==e.indexOf(_t.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,_t.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<_t.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,_t.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,_t.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+_t.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=_t.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt extends Nt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Pt(e);if($t.isMolfileV3K(e))return new Rt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return Rt.isValidMolfile(e)}}var Ot=n(6197),kt=n(9124),Ht=n(3527);class Bt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Bt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ft extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Dt extends Bt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Gt extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Vt extends Bt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class qt extends Bt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class jt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new qt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new jt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Wt={[He.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[He.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[He.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[He.o.CHEM]:{R:"#eeeeee"},[He.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Ut=/.*\|\$.*R.*\$\|/,zt=/\[R(\d+)\]/,Yt=/\[R(\d+)\]/g,Kt=/\[\*:(\d+)\]/g;function Zt(e,t){const n=Array.from(e.matchAll(Yt)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=kn(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){vs.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const Xt=/[\w()]+/,Jt=RegExp(String.raw`\(${Xt}(,${Xt})+\)`),Qt=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},en=new Ht.Mi([255,255,255]),tn=new Ht.Mi([0,0,0]),nn=.7*(0,j.wQ)(en);class on{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==pe._S||t===pe.b9[pe.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(Ut.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return Zt(a,t)}let n=e;const i=Array.from(e.matchAll(Kt));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(zt.test(n))return Zt(n,t)}catch(t){vs.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Ft((0,$e.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,kt.fA)(e,t),o=(0,Ot.Y)(n);let r=this.getMonomer(o,i);if(r&&n==He.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==He.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===pe._S||"*"==i?s=r.wem=new Dt(n):n===He.o.NUCLEOTIDE&&"N"===i||n===He.o.AA&&"X"===i||(He.o.CHEM,0)||Jt.test(i)?s=r.wem=new Gt(n,i):r.lib||(s=r.wem=new Vt(n,i,this.isEmpty)),s||(s=r.wem=jt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Ot.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?Qt(s.molfile):s.smiles?r.divV([Qt(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=pe._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Ht.Mi([...o.map(e=>e+1)]),a=(0,j.KE)(r,en)/((0,j.wQ)(r)*(0,j.wQ)(en)),l=i(n.backgroundcolor),c=new Ht.Mi([...l.map(e=>e+.01)]);let u;u=(0,j.KE)(c,en)/((0,j.wQ)(c)*(0,j.wQ)(en))<a?l:o;let h=new Ht.Mi(u);const d=(0,j.wQ)(h);return d>nn&&(h=(0,j.dC)(tn,h,nn/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Ot.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){vs.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Wt[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var rn=n(5488),sn={};sn.styleTagTransform=C(),sn.setAttributes=y(),sn.insert=g().bind(null,"head"),sn.domAPI=m(),sn.insertStyleElement=v(),h()(rn.A,sn),rn.A&&rn.A.locals&&rn.A.locals;class an extends on{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,Ot.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,_e.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new ln(e,`override: ${++an.overrideCounter}, ${t}`,this)}}class ln extends on{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var cn=n(8604),un=n(7433),hn=n.n(un),dn=n(1913),mn=n.n(dn);class pn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(hn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});mn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class gn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=ye.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText(gn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new pn(i);gn._instance=new gn(r,e,t),gn._instance.refreshLists()}return gn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new ye.lH(n,i,o,r,s)});t.push(new ye.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}const fn="System:AppData/Bio/monomer-collections/";class yn{logger;_monomerLib=new an({},"MAIN");_monomerSets=new ye.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await s.delay(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await gn.getInstance(this,vs.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++yn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return yn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,_e.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new an(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,_e.E)(cn.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new an(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===ye.ic);if(!t)throw new Error(`Provider '${ye.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new an(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,ye.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async listMonomerCollections(){return(await o.dapi.files.list(fn)).filter(e=>"json"===e.extension||e.name.endsWith(".json")).map(e=>e.name)}async deleteMonomerCollection(e){e.endsWith(".json")||(e+=".json"),await o.dapi.files.exists(fn+e)&&await o.dapi.files.delete(fn+e)}async readMonomerCollection(e){e.endsWith(".json")||(e+=".json");const t=await o.dapi.files.readAsText(fn+e);return JSON.parse(t)}async addOrUpdateMonomerCollection(e,t,n,i){e.endsWith(".json")||(e+=".json");const r=JSON.stringify({description:n,tags:i,monomerSymbols:t,updatedBy:s.User.current().login,updatedOn:(new Date).toISOString()},null,2);await o.dapi.files.writeAsText(fn+e,r)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new yn(vs.logger))()),e}}var bn=n(857),vn={};vn.styleTagTransform=C(),vn.setAttributes=y(),vn.insert=g().bind(null,"head"),vn.domAPI=m(),vn.insertStyleElement=v(),h()(bn.A,vn),bn.A&&bn.A.locals&&bn.A.locals;const wn=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];function Cn(e,t,n){let i=t[e]??n[e];if(i&&i.length>0)return i;const r=Hn(e,wn);if(r!==e){const e=o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles);if(i=t[e]??n[e],i&&i.length>0)return i}return[]}function An(e){const t=new Set;return e.filter(e=>!t.has(e.symbol)&&(t.add(e.symbol),!0))}function Sn(e,t){const n=new Set;for(const i of e){const e=t[i.symbol];if(e&&e.length>0)for(const t of e){const e=t?.lib?.source;e&&n.add(e)}else i.source&&n.add(i.source)}return Array.from(n).join(", ")}var xn;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(xn||(xn={}));const En={[xn.MONOMER]:s.COLUMN_TYPE.STRING,[xn.SYMBOL]:s.COLUMN_TYPE.STRING,[xn.NAME]:s.COLUMN_TYPE.STRING,[xn.R_GROUPS]:s.COLUMN_TYPE.STRING,[xn.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[xn.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[xn.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[xn.AUTHOR]:s.COLUMN_TYPE.STRING,[xn.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[xn.ID]:s.COLUMN_TYPE.INT,[xn.META]:s.COLUMN_TYPE.STRING,[xn.SOURCE]:s.COLUMN_TYPE.STRING};async function Mn(e){const t=await Tn(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>Bn(t.rows.get(n))))}async function Tn(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(En))if(t.columns.addNew(e,n),e===xn.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(xn.SYMBOL).semType="Monomer",t.col(xn.SYMBOL).setTag(Pe.Mn.applyToBackground,"true"),t.col(xn.SYMBOL).setTag(pe.qE.polymerTypeColumnName,xn.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=On(e[n].rgroups,e[n].smiles,e[n].molfile);o=_n(o),e[n].rgroups=Rn(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?Nn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(xn.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(xn.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class In{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(xn.NAME).width=100,this.tv.grid.col(xn.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new $n(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(xn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await yn.getInstance();await e.awaitLoaded(),this.instance=new In(e)}return this.instance}static async getNewInstance(){const e=await yn.getInstance();return await e.awaitLoaded(),new In(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewMonomersCollectionDialog(e){const t=(await this.monomerLibManamger.listMonomerCollections()).map(e=>e.toLowerCase()),n=r.input.string("Collection Name",{tooltipText:"Name of the monomer collection, should be unique",placeholder:"Enter collection name",nullable:!1}),i=r.input.string("Description",{tooltipText:"Description of the monomer collection",placeholder:"Enter collection description",nullable:!0}),s=r.dialog("Create New Monomer Collection").add(n).add(i).addButton("Add",async()=>{if(!n.value||!n.value.trim())return void o.shell.warning("Collection name cannot be empty");const a=async e=>{await this.monomerLibManamger.addOrUpdateMonomerCollection(n.value,e,i.value??void 0),o.shell.info(`Collection ${n.value} saved successfully`)};if(t.includes(n.value.toLowerCase())||t.includes(n.value.toLowerCase()+".json")){const t=r.dialog("Collection already exists").add(r.divText(`A collection with the name ${n.value} already exists. Do you want to merge or overwrite it?`));t.addButton("Merge",async()=>{const i=await this.monomerLibManamger.readMonomerCollection(n.value),r=Array.from(new Set([...i.monomerSymbols??[],...e]));try{await a(r)}catch(e){o.shell.error("Error merging monomer collection"),console.error(e)}t.close()}),t.addButton("Overwrite",async()=>{try{await a(e)}catch(e){o.shell.error("Error overwriting monomer collection"),console.error(e)}t.close()}),t.show()}else try{await a(e)}catch(e){o.shell.error("Error creating monomer collection"),console.error(e)}s.close()}).show()}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex,n=e.menu;if(n.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),n.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0){const e=n.group("Selected Monomers");e.item("Remove",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Bn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.item("Create Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Bn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}),e.item("Create Collection",async()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>this.tv.dataFrame.col(xn.SYMBOL).get(e)).filter(e=>!!e&&e.trim().length>0);if(0===e.length)return o.shell.warning("No valid monomer symbols found in selection");this.createNewMonomersCollectionDialog(e)})}else n.item("Remove Monomer",async()=>{const e=await Bn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===In.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:In.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Bn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Bn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=In.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Bn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,ye.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await Tn(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,ye.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Bn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const Ln=["alternateId","capGroupName","capGroupSMILES","label"];function Nn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Pn(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function Rn(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(Ln,e),n=Nn(t,"capGroupSMILES"),i=Nn(t,"alternateId"),o=Nn(t,"capGroupName"),r=Nn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class $n{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=On([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await It(Hn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Et(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Et(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Rn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&It(Hn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=On(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(xn.POLYMER_TYPE)?.toList()??[],s=n?.col(xn.SYMBOL)?.toList()??[],a=n?.col(xn.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,ye.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await Bn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await Bn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=On([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=kn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function On(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=_n(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function kn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function Hn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=Nn(e,"capGroupName"),r=Nn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function Bn(e){let t;try{t=JSON.parse(e.get(xn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(xn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=kn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(xn.NATURAL_ANALOG);const a=e.get(xn.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(xn.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=Nn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?Pn(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?Pn(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?Pn(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&Pn(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=Nn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&Pn(e,"capGroupSMILES",`${Nn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await It(Hn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(xn.SYMBOL),name:e.get(xn.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(xn.MONOMER_TYPE),naturalAnalog:r,id:e.get(xn.ID),rgroups:l,meta:t,author:e.get(xn.AUTHOR),createDate:e.get(xn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}function Dn(e){const t={Symbol:e.symbol,Name:e.name,"Polymer Type":e.polymerType,"Monomer Type":e.monomerType};if(e.author&&(t.Author=e.author),e.naturalAnalog&&(t["Natural Analog"]=e.naturalAnalog),e.lib?.source){let n=e.lib.source;n.endsWith(".json")&&(n=n.substring(0,n.length-5)),t.Library=n}e.molfile?t.Structure=o.chem.drawMolecule(e.molfile,150,150):e.smiles&&(t.Structure=o.chem.drawMolecule(e.smiles,150,150));const n=e.rgroups;if(n&&n.length>0)for(const e of n)t[e.label??"?"]=e.alternateId??"";return r.tableFromMap(t)}function Gn(e){const t=function(e){try{return Hn(On(e.rgroups,e.smiles,e.molfile),e.rgroups)}catch{}return null}(e);if(!t)return r.divText("No molecular structure available");const n=s.SemanticValue.fromValueType(t,s.SEMTYPE.MOLECULE);return r.panels.infoPanel(n).root}var Vn=n(3890),qn=n(1687);function jn(e){return e.split(/,(?![^(]*\))/).map(e=>('"'===(e=e.trim()).slice(0,1)&&'"'===e.slice(-1)&&(e=e.slice(1,-1)),"'"===e.slice(0,1)&&"'"===e.slice(-1)&&(e=e.slice(1,-1)),e.trim())).filter(e=>!!e)}class Wn{constructor(e,t,n,i){this.currentMenu=null,this.menuItems=[],this.highlightedIndex=-1,this.monomerLib=e,this.polymerType=t,this.helmType=(0,$e.MD)(t),this.allSymbols=e.getMonomerSymbolsByType(t),this.libHelper=i,this.selectedMonomers=n?[...n]:[],this.tagsHost=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px",marginTop:"4px",maxHeight:"150px",overflowY:"auto"}}),this.countLabel=r.divText("",{style:{fontSize:"11px",color:"var(--grey-4)",marginTop:"4px"}});const o=r.input.string("Search",{value:""});this.inputEl=o.input,this.inputEl.setAttribute("autocomplete","off"),this.inputEl.placeholder="Type to search monomers...",this.setupInputListeners();const s=this.createLibrarySection(),a=this.createCollectionSection(),l=r.button("Clear all",()=>{this.selectedMonomers.length=0,this.renderTags()});l.style.fontSize="11px",l.style.marginTop="4px",this.renderTags(),this.root=r.div([o.root,s,a,r.divH([this.countLabel,l],{style:{justifyContent:"space-between",alignItems:"center"}}),this.tagsHost],{style:{minWidth:"300px"}})}getSelectedMonomers(){return[...this.selectedMonomers]}setSelectedMonomers(e){this.selectedMonomers.length=0,this.selectedMonomers.push(...e),this.renderTags()}setPolymerType(e){this.polymerType=e,this.helmType=(0,$e.MD)(e),this.allSymbols=this.monomerLib.getMonomerSymbolsByType(e)}focus(){this.inputEl.focus()}updateCountLabel(){this.countLabel.textContent=this.selectedMonomers.length>0?`${this.selectedMonomers.length} monomer(s) selected`:""}renderTags(){this.tagsHost.innerHTML="";for(const e of this.selectedMonomers){const t=r.iconFA("times",()=>{const t=this.selectedMonomers.indexOf(e);t>=0&&(this.selectedMonomers.splice(t,1),this.renderTags(),this.updateCountLabel())});t.style.marginLeft="4px",t.style.cursor="pointer";const n=r.div([r.span([e]),t],{style:{display:"inline-flex",alignItems:"center",padding:"2px 6px",borderRadius:"4px",backgroundColor:"var(--grey-2)",border:"1px solid var(--grey-3)",fontSize:"12px",cursor:"default"}});n.addEventListener("mouseenter",()=>{const t=this.monomerLib.getTooltip(this.helmType,e);r.tooltip.show(t,n.getBoundingClientRect().left,n.getBoundingClientRect().bottom+16)}),n.addEventListener("mouseleave",()=>{r.tooltip.hide()}),this.tagsHost.appendChild(n)}this.updateCountLabel()}addMonomer(e){this.selectedMonomers.includes(e)||(this.selectedMonomers.push(e),this.renderTags()),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}addMonomers(e){let t=!1;for(const n of e)this.selectedMonomers.includes(n)||(this.selectedMonomers.push(n),t=!0);t&&this.renderTags()}hideMenu(){this.currentMenu&&(this.currentMenu.hide(),this.currentMenu=null),this.menuItems=[],this.highlightedIndex=-1}getSuggestions(e){const t=e.toLowerCase(),n=[];for(const e of this.allSymbols){if(this.selectedMonomers.includes(e))continue;const i=this.monomerLib.getMonomer(this.polymerType,e),o=e.toLowerCase(),r=i?.name?.toLowerCase()??"";o.startsWith(t)?n.push({symbol:e,monomer:i,rank:0}):o.includes(t)?n.push({symbol:e,monomer:i,rank:1}):r.includes(t)&&n.push({symbol:e,monomer:i,rank:2})}return n.sort((e,t)=>e.rank-t.rank||e.symbol.localeCompare(t.symbol)),n.slice(0,20)}showSuggestions(){this.hideMenu();const e=this.inputEl.value.trim();if(!e)return;const t=this.getSuggestions(e);if(0===t.length)return;this.currentMenu=s.Menu.popup();const n=t.reduce((e,t)=>{const n=t.monomer?.name?`${t.symbol} - ${t.monomer.name}`:t.symbol;return e.length<n.length?n:e},"");this.currentMenu.item(n,()=>{});const i=new MouseEvent("mousemove",{clientX:this.inputEl.getBoundingClientRect().left,clientY:this.inputEl.getBoundingClientRect().bottom});this.currentMenu.show({causedBy:i,y:this.inputEl.offsetHeight+this.inputEl.offsetTop,x:this.inputEl.offsetLeft}),setTimeout(()=>{this.currentMenu?.clear();for(const e of t){const t=e.monomer?.name?`${e.symbol} - ${e.monomer.name}`:e.symbol;this.currentMenu?.item(t,()=>{this.addMonomer(e.symbol)})}const e=document.querySelector(".d4-menu-popup:last-of-type");e&&(this.menuItems=Array.from(e.querySelectorAll(".d4-menu-item"))),this.highlightedIndex=-1},0)}updateHighlight(e){0!==this.menuItems.length&&(this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&this.menuItems[this.highlightedIndex].classList.remove("d4-menu-item-hover"),this.highlightedIndex=e,this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length&&(this.menuItems[this.highlightedIndex].classList.add("d4-menu-item-hover"),this.menuItems[this.highlightedIndex].scrollIntoView({block:"nearest"})))}setupInputListeners(){this.inputEl.addEventListener("input",()=>{this.showSuggestions()}),this.inputEl.addEventListener("paste",e=>{const t=e.clipboardData?.getData("text");if(!t)return;const n=t.split(/[\n\r]+/).map(e=>e.trim()).filter(e=>e.length>0),i=[];for(const e of n){const t=jn(e);1===t.length&&e.includes(" ")&&!e.includes(",")?i.push(...e.split(/\s+/).map(e=>e.trim()).filter(e=>e.length>0)):i.push(...t)}if(!(i.length<=1)){e.preventDefault();for(const e of i)this.selectedMonomers.includes(e)||this.selectedMonomers.push(e);this.renderTags(),this.inputEl.value="",this.hideMenu(),this.inputEl.focus()}}),this.inputEl.addEventListener("keydown",e=>{if("ArrowDown"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex+1)%this.menuItems.length;this.updateHighlight(e)}}else if("ArrowUp"===e.key){if(e.preventDefault(),this.menuItems.length>0){const e=(this.highlightedIndex-1+this.menuItems.length)%this.menuItems.length;this.updateHighlight(e)}}else if("Enter"===e.key)if(e.preventDefault(),e.stopPropagation(),this.highlightedIndex>=0&&this.highlightedIndex<this.menuItems.length)this.menuItems[this.highlightedIndex].click();else{const e=this.inputEl.value.trim();e&&this.addMonomer(e)}else"Escape"===e.key&&this.hideMenu()})}createLibrarySection(){const e=r.div([],{style:{marginTop:"8px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from library",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.getAvaliableLibraryNames().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=await t.readSingleLibraryByName(e);if(n){const t=n.getMonomerSymbolsByType(this.polymerType),o=this.selectedMonomers.length;this.addMonomers(t);const r=this.selectedMonomers.length-o;i.textContent=`Added ${r} monomer(s) from "${e}"`}else i.textContent=`Library "${e}" not found`}catch(e){i.textContent="Error loading library"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}createCollectionSection(){const e=r.div([],{style:{marginTop:"4px"}});if(!this.libHelper)return e;const t=this.libHelper,n=r.input.choice("Add from collection",{items:[],nullable:!0}),i=r.divText("",{style:{fontSize:"11px",color:"var(--green-2)",marginLeft:"8px",minHeight:"16px"}});return t.listMonomerCollections().then(e=>{n.items=e}),n.onChanged.subscribe(async()=>{const e=n.value;if(e){i.textContent="Loading...";try{const n=(await t.readMonomerCollection(e)).monomerSymbols??[],o=this.selectedMonomers.length;this.addMonomers(n);const r=this.selectedMonomers.length-o,s=e.replace(/\.json$/,"");i.textContent=`Added ${r} monomer(s) from "${s}"`}catch(e){i.textContent="Error loading collection"}n.value=null,setTimeout(()=>{i.textContent=""},4e3)}}),e.appendChild(r.divV([n.root,i])),e}}class Un extends s.ObjectHandler{get type(){return"MonomerCollection"}get name(){return"Monomer Collection"}isApplicable(e){return Array.isArray(e)?e.length>0&&e.every(e=>this.isSingleCollection(e)):this.isSingleCollection(e)}isSingleCollection(e){return null!=e&&"object"==typeof e&&"name"in e&&"displayName"in e&&"data"in e&&void 0!==e.data?.monomerSymbols}getCaption(e){return Array.isArray(e)?`${e.length} collections`:e.displayName}renderProperties(e,t=null){return Array.isArray(e)?this.renderMultiProperties(e):this.renderSingleProperties(e)}renderSingleProperties(e){const t=r.accordion("Monomer Collection"),n=s.User.current().login,i=e.data.updatedBy===n;return t.addPane("Details",()=>{const t={Name:e.displayName};if(e.data.description&&(t.Description=e.data.description),e.data.tags&&e.data.tags.length>0&&(t.Tags=e.data.tags.join(", ")),t.Monomers=`${e.data.monomerSymbols.length}`,e.data.updatedBy&&(t["Updated by"]=e.data.updatedBy),e.data.updatedOn)try{t["Updated on"]=new Date(e.data.updatedOn).toLocaleString()}catch{}return r.tableFromMap(t)},!0),t.addPane("Monomers",()=>{const t=r.div([],{style:{display:"flex",flexWrap:"wrap",gap:"4px"}}),n=this.getMonomerLib();for(const i of e.data.monomerSymbols){const e=r.div([i],{style:{display:"inline-block",padding:"2px 8px",borderRadius:"4px",background:"var(--grey-1)",border:"1px solid var(--grey-2)",fontSize:"11px",color:"var(--grey-5)",cursor:"pointer"}});e.addEventListener("mouseenter",()=>{if(n){const t=Un.getMonomerTooltipSafe(n,i);if(t){const n=e.getBoundingClientRect();r.tooltip.show(t,n.left,n.bottom+4)}}}),e.addEventListener("mouseleave",()=>r.tooltip.hide()),e.addEventListener("click",()=>{o.shell.o=s.SemanticValue.fromValueType(i,Ge.uF.MONOMER)}),t.appendChild(e)}return t},!0),t.addPane("Actions",()=>{const t=[],n=r.button("Edit",async()=>{i&&await this.editCollection(e)},i?"Edit this collection":"Only the author can edit");i||Un.disableButton(n),t.push(n);const o=r.button("Delete",async()=>{i&&await this.deleteCollection(e)},i?"Delete this collection":"Only the author can delete");return i||Un.disableButton(o),t.push(o),t.push(r.button("Duplicate",async()=>{await this.duplicateCollection(e)},"Create a copy of this collection")),r.divH(t)},!0),t.root}renderMultiProperties(e){const t=r.accordion("Monomer Collections"),n=s.User.current().login,i=e.every(e=>e.data.updatedBy===n);return t.addPane("Selection",()=>{const t=r.list(e.map(e=>e.displayName));return r.divV([r.divText(`${e.length} collections selected`),t])},!0),t.addPane("Actions",()=>{const t=[];t.push(r.button("Merge",async()=>{await this.mergeCollections(e)},"Merge selected collections into one"));const n=r.button("Delete All",async()=>{i&&await this.deleteMultipleCollections(e)},i?"Delete all selected collections":"Only the author can delete (you must be author of all)");return i||Un.disableButton(n),t.push(n),r.divH(t)},!0),t.root}async editCollection(e){const t=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(t&&t._mcView)t._mcView.editCollectionPublic(e.name,e.data);else{const t=await yn.getInstance();await t.awaitLoaded();const n=t.getMonomerLib();this.showEditDialog(e,t,n)}}showEditDialog(e,t,n){const i=r.input.string("Name",{value:e.displayName,nullable:!1}),s=r.input.string("Description",{value:e.data.description??"",nullable:!0}),a=r.input.string("Tags",{value:(e.data.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(n,l.value,[...e.data.monomerSymbols??[]],t);l.onChanged.subscribe(()=>c.setPolymerType(l.value)),r.dialog({title:`Edit Collection: ${e.displayName}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const n=i.value?.trim();if(!n)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=this.parseTags(a.value);try{n!==e.displayName&&await t.deleteMonomerCollection(e.name),await t.addOrUpdateMonomerCollection(n,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${n}" saved successfully`),await this.refreshView()}catch(e){o.shell.error("Error saving collection")}}).show({resizable:!0}).root.style.width="550px",c.focus()}async deleteCollection(e){r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete "${e.displayName}"?`)).onOK(async()=>{try{const t=await yn.getInstance();await t.deleteMonomerCollection(e.name),o.shell.info(`Collection "${e.displayName}" deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collection")}}).show()}async duplicateCollection(e){const t=r.input.string("New Name",{value:`${e.displayName} (copy)`,nullable:!1});r.dialog({title:"Duplicate Collection"}).add(t).onOK(async()=>{const n=t.value?.trim();if(n)try{const t=await yn.getInstance();await t.addOrUpdateMonomerCollection(n,[...e.data.monomerSymbols],e.data.description,e.data.tags?[...e.data.tags]:void 0),o.shell.info(`Collection "${n}" created`),await this.refreshView()}catch(e){o.shell.error("Error duplicating collection")}else o.shell.warning("Name is required")}).show()}async mergeCollections(e){const t=r.input.string("Merged Name",{value:"Merged Collection",nullable:!1}),n=r.input.string("Description",{nullable:!0,placeholder:"Optional description"});r.dialog({title:`Merge ${e.length} Collections`}).add(r.divV([r.divText(`Merging: ${e.map(e=>e.displayName).join(", ")}`),t,n])).onOK(async()=>{const i=t.value?.trim();if(i)try{const t=[...new Set(e.flatMap(e=>e.data.monomerSymbols))],r=[...new Set(e.flatMap(e=>e.data.tags??[]))],s=await yn.getInstance();await s.addOrUpdateMonomerCollection(i,t,n.value??void 0,r.length>0?r:void 0),o.shell.info(`Merged collection "${i}" created with ${t.length} monomers`),await this.refreshView()}catch(e){o.shell.error("Error merging collections")}else o.shell.warning("Name is required")}).show()}async deleteMultipleCollections(e){r.dialog({title:"Delete Collections"}).add(r.divText(`Are you sure you want to delete ${e.length} collections?\n${e.map(e=>e.displayName).join(", ")}`)).onOK(async()=>{try{const t=await yn.getInstance();for(const n of e)await t.deleteMonomerCollection(n.name);o.shell.info(`${e.length} collections deleted`),await this.refreshView()}catch(e){o.shell.error("Error deleting collections")}}).show()}async refreshView(){const e=Array.from(o.shell.views).find(e=>"Monomer Collections"===e.name);if(e&&e._mcView){const t=e._mcView;await t.refresh()}}parseTags(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}getMonomerLib(){return vs.monomerLib??null}static getMonomerTooltipSafe(e,t){const n=[He.o.AA,He.o.NUCLEOTIDE,He.o.CHEM,He.o.BLOB];for(const i of n)try{if(e.getWebEditorMonomer(i,t))return e.getTooltip(i,t)}catch{}return null}static disableButton(e){e.style.opacity="0.4",e.style.cursor="default"}static buildContextMenu(e,t,n){const i=s.User.current().login,o=t.data.updatedBy===i;e.item("Edit",()=>{o&&n.editCollection(t)},null,{isEnabled:()=>o?null:"Only the author can edit"}),e.item("Delete",()=>{o&&n.deleteCollection(t)},null,{isEnabled:()=>o?null:"Only the author can delete"}),e.item("Duplicate",()=>n.duplicateCollection(t))}static buildMultiContextMenu(e,t,n){const i=s.User.current().login,o=t.every(e=>e.data.updatedBy===i);e.item("Merge",()=>n.mergeCollections(t)),e.item("Delete All",()=>{o&&n.deleteMultipleCollections(t)},null,{isEnabled:()=>o?null:"Only the author can delete (you must be author of all)"})}}var zn=n(1757),Yn=n.n(zn);class Kn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Zn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Kn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Xn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Xn._instance||(Xn._instance=new Xn,await Xn._instance.refresh(),(await yn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Xn._instance.refresh())),Xn._instance.refresh(),Xn._instance}async refresh(){this.settings=await(0,_e.u)();const e=await yn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Zn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,_e.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,_e.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Jn=n(3017),Qn={};async function ei(){await ri.showDialog()}async function ti(e=!0){return await si.showView(e)}Qn.styleTagTransform=C(),Qn.setAttributes=y(),Qn.insert=g().bind(null,"head"),Qn.domAPI=m(),Qn.insertStyleElement=v(),h()(Jn.A,Qn),Jn.A&&Jn.A.locals&&Jn.A.locals;class ni{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==ni.instancePromise&&(ni.instancePromise=(async()=>{const e=new ni,t=await(0,ye.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),ni.instancePromise}static async reloadWidget(){const e=await ni.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,ye.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await ii.createControlsForm();return Yn()(e).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),setTimeout(()=>{e&&Yn()(e)&&Yn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class ii{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){vs.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,_e.u)(),t=await(0,ye.pj)();return new ii(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Yn()(t).addClass("monomer-lib-controls-form").addClass("d4-dialog-contents"),t}async updateControlsForm(){const e=await this._createControlsForm();Yn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;vs.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{oi(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=r.icons.edit(async()=>{o.shell.v=await(await In.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),vs.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await oi(!1,e);const n=await(0,ye.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function oi(e,t){const n=await(0,_e.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,_e.E)(n);const i=await(0,ye.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class ri{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){ri._instance||(ri._instance=new ri,ri._instance.closeDialogSubject$.subscribe(()=>{ri._instance.dialog=void 0})),ri._instance.dialog||(ri._instance.dialog=await ri._instance.getDialog()),ri._instance.dialog.show()}async getDialog(){const e=(await ni.getInstance()).widget,t=await(0,ye.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Yn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class si{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await ni.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=si.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=si._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return si._instance||(si._instance=new si),si._instance._duplicateManager||(si._instance._duplicateManager=await Xn.getInstance()),si._instance.libManager||(si._instance.libManager=await yn.getInstance()),e&&si._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===si._instance._view.id)?(o.shell.v=si._instance._view,await si._instance._duplicateManager.refresh(),si._instance._view):(si.closeExistingViews(),si._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===si.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await yn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,_e.u)();i.exclude=l,await(0,_e.E)(i),await this.libManager.loadMonomerLib(!0),await ni.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var ai,li=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ci{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>li(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>li(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>li(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>li(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,ci.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return li(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield s.delay(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep===this.stepNumber)return this._restartBtn.disabled=!1,void(this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn));if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))})}_startScript(){return li(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return li(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return li(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return li(this,void 0,void 0,function*(){this._restartBtn.disabled=!0,o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ci.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return li(this,void 0,void 0,function*(){var e;(null===(e=o.shell.v)||void 0===e?void 0:e.name)===this.name&&o.shell.v.close(),this._initRoot(),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ci.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(ai||(ai={}));var ui=n(966),hi=n(608),di=n(1619);class mi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${vs.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case et.n5.fixWidth:case et.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class pi{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var gi=n(6869);const fi="-";class yi extends De{constructor(e,t){super(e,t)}static _canonLoadingKey=pe.sc+".loading";getCanonicalizer(e){const t=e.temp[pe.sc]??null;if(t)return t;if(e.temp[yi._canonLoadingKey])return null;const n=e.getTag(pe.jz);if(!n)return null;const i=n.includes(":")?n.split(":"):[void 0,n],o=s.Func.find({name:i[1],package:i[0]});return 0===o.length||(e.temp[yi._canonLoadingKey]=!0,o[0].apply({}).then(t=>{e.temp[pe.sc]=t,e.temp[yi._canonLoadingKey]=!1,this.gridCol?.grid?.invalidate&&this.gridCol.grid.invalidate()}).catch(()=>{e.temp[yi._canonLoadingKey]=!1})),null}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Pe.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";const a=e.measureText("M"),l=a.actualBoundingBoxAscent+a.actualBoundingBoxDescent+8;let c=r.cell.value;c&&c!==pe._S||(c=fi);const u=c.split(pe.ot).map(e=>e&&e!==pe._S?e.trim():fi),h=u.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/u.length)))),d=h.map(t=>e.measureText(t).width+4),m=d.reduce((e,t)=>e+t,0);let p=t+(i-m)/2+2;const g=this.tableCol.getTag(pe.gp.alphabet),f=g===ue.YI.RNA||g===ue.YI.DNA?gi.o.NUCLEOTIDE:gi.o.AA;for(let a=0;a<h.length;a++){const c=u[a],m=this.getHelmType(r,f);let g=Re.S$,y="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,c);g=e?.textcolor??g,y=e?.backgroundcolor??y}else g=this.monomerLib.getMonomerTextColor(m,c);if(s)if(e.fillStyle=y,i<30||o<30)e.fillRect(t+a*i/h.length,n,i/h.length,o);else{const t=2;e.roundRect(p-2,n+o/2-l/2,d[a],l,t),e.fill()}e.fillStyle=g,e.fillText(h[a],p,n+o/2,i),p+=d[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,ke.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(pe.gp.alphabet),a=e.cell.value,l=this.getCanonicalizer(i),c=l&&a?l.canonicalize(a):a,u=e.grid.canvas.getBoundingClientRect(),h=e.bounds.right+u.left-4,d=e.bounds.bottom+u.top-4;if(!a||a==pe._S||a==fi||null!=l&&l.isGap(a))return r.tooltip.show(r.divText("gap"),h,d),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),h,d),!0;const m=s===ue.YI.RNA||s===ue.YI.DNA?gi.o.NUCLEOTIDE:gi.o.AA,p=c.split(pe.ot).map(t=>{if(!t||t===pe._S||t===fi)return r.divText("gap");const n=this.getHelmType(e,m);return this.monomerLib.getTooltip(n,t)}),g=r.divH(p,{style:{alignItems:"top",flexWrap:"wrap",gap:"4px"}}),f=Array.from(g.querySelectorAll("canvas"));if(f.length>2){const e=Math.floor(550/f.length);f.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(g,h,d),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,ke.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(pe.qE.polymerTypeColumnName)){const t=o.getTag(pe.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,$e.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new yi(t,n)),o}}class bi extends s.GridCellRenderer{get name(){return Ge.uF.MONOMER}get cellType(){return Ge.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){yi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){yi.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class vi{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class wi extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class Ci extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new vi(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ve.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var Ai=n(6307),Si=n(5999),xi={};xi.styleTagTransform=C(),xi.setAttributes=y(),xi.insert=g().bind(null,"head"),xi.domAPI=m(),xi.insertStyleElement=v(),h()(Si.A,xi),Si.A&&Si.A.locals&&Si.A.locals;class Ei extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=vs.properties.tooltipWebLogo,n=this.seqCol.getTag(Xe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}var Mi=n(4951);function Ti(e,t,n,i){const o=vs.seqHelper.getSeqHandler(e);let r=null,a=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(a=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==a&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<a)throw new Error(`End position ${a} exceeds positions length`);const l=i||`${e.name}: (${t??""}-${n??""})`,c=function(e,t,n,i,o){if(!n||!i||!e.dataFrame)return null;const r=e.getTag(ue.gp.annotations);if(!r)return null;let a;try{a=JSON.parse(r)}catch{return null}const l=a.find(e=>e.category===xt.eI.Structure&&e.start===n&&e.end===i);if(!l)return null;const c=(0,St.VT)(e.name);let u=null;try{u=e.dataFrame.columns.byName(c)}catch{return null}if(!u)return null;const h=(0,St.wi)(u);if(!h.some(e=>e?.some(e=>e.annotationId===l.id&&null!=e.endPositionIndex)))return null;const d=e.dataFrame,m=s.Column.fromType(s.COLUMN_TYPE.STRING,o,d.rowCount);for(let e=0;e<d.rowCount;e++){const n=h[e],i=n?.find(e=>e.annotationId===l.id&&null!=e.endPositionIndex);if(i){const n=t.getSplitted(e),o=[];for(let e=i.positionIndex;e<=i.endPositionIndex;e++)e<n.length&&o.push(n.getOriginal(e));m.set(e,o.join(t.separator||""))}else m.set(e,"")}return m}(e,o,t,n,l);return c||o.getRegion(r,a,l)}const Ii={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class _i{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??Ii;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${vs.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Li{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value;let t=null;const n=e?e.getTag(ue.gp.annotations):null;if(n)try{const e=JSON.parse(n).filter(e=>"structure"===e.category&&e.start&&e.end);e.length>0&&(t=e.map(e=>({name:e.name,description:e.description??"",start:e.start,end:e.end})))}catch{}if(!t){const n=e?e.getTag(ue.gp.regions):null;t=n?JSON.parse(n):null}const i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=t){this.inputs.region.root.style.removeProperty("display");for(const e of t){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{vs.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{vs.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var Ni=n(8754);async function Pi(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=ge(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):pe._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=ge(e,n).columns.toList());const i=(await(0,ye.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):pe._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==pe._S&&t!==p?l[e]+=y[t]:c===pe._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null==u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Ri=n(294),$i=n(330);const Oi=OCL;var ki=n(2582);class Hi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var Bi=n(6956);class Fi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===Bi.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=$t.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const v=new Map;v.set(p+1,e+1);let w=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),v.set(e+1,w),w++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=v.get(t),o=v.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Di{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Gi extends Di{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class Vi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class qi extends Vi{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class ji extends Hi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Gi(n),this.bonds=new qi(n),this.rGroups=new Fi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Wi extends Di{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Ui extends Vi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class zi extends Hi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Wi(n),this.bonds=new Ui(n),this.rGroups=new Fi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Yi{static getInstance(e,t){if($t.isMolfileV2K(e))return new ji(e,t);if($t.isMolfileV3K(e))return new zi(e,t);throw new Error("Unsupported molfile version")}}class Ki{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Yi.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Ki.molfileV2KToV3KCache.has(e))return Ki.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Ki.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Zi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new ki.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===pe.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Ki(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Ri.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?He.o.NUCLEOTIDE:He.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Xi{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Ji{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Oi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,ve.AP)(e);return vs.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,$i.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Ri.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,ve.AP)(e);vs.logger.error(t,void 0,n),o=Ri.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Xi(o),s=new Zi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Ri.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Ri.vF(a.molfile,l)}}var Qi=n(2738);class eo{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[me.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}runInnerDetector(){if(!this._column.temp.seqHandlerDetectorRun){this._column.temp.seqHandlerDetectorRun=!0;const e=s.Func.find({name:"detectMacromolecule",meta:{role:"semTypeDetector"}})[0];e&&e.applySync({col:this._column})}}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;let n=this._column.meta.units;if(!n&&(this.runInnerDetector(),n=this._column.meta.units,!n))throw new Error("Units are not specified in column");if(this._units=n,this._notation=this.getNotation(),[ue.Hi.BILN,ue.Hi.CUSTOM,ue.Hi.SEPARATOR].includes(this._notation)&&!this.column.getTag(ue.gp.separator)&&(this.runInnerDetector(),!this.column.getTag(ue.gp.separator)))throw new Error(`Separator tag '${ue.gp.separator}' is not set for notation '${this._notation}'.`);(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[me.j.notationProvider]??null);const i=this.isFasta()?pe.b9[ue.Hi.FASTA]:this.isSeparator()?pe.b9[ue.Hi.SEPARATOR]:this.isHelm()?pe.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??pe.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[me.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.BILN].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength||e.column.categories.slice(0,5).filter(e=>!!e).every(e=>e.length>100)?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,$e.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new Qi.aD(e.name,e.alphabet,.9));t=(0,$e.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?He.o.NUCLEOTIDE:He.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===pe.b9[ue.Hi.FASTA]?pe._S:i??pe._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(pe._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===pe.b9[ue.Hi.FASTA]?pe._S:o??pe._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new me.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!eo.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:$e.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?pe.b9[ue.Hi.FASTA]:pe.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===pe.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=pe.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new $e.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return to(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return no(n,t,e)};break}case ue.Hi.BILN:i=function(e){return io(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[me.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[me.j.seqHandler]=new eo(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return to(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return no(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:io(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new $e.Mu(n.filter(e=>!!e),pe.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function to(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===pe._S?r=pe.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function no(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===pe._S?r=pe.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===pe._S?s=pe.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function io(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class oo{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return eo.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,kt.b2)();return new Ji(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Ri.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Ri.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Ri.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Ri.vF(e,o.monomers)}catch(e){const[t,n]=(0,ve.AP)(e);return vs.logger.error(t,void 0,n),Ri.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,$i.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,eo.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),eo.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,eo.setTags(e)}}async function ro(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await Cs.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[me.j.notationProvider]&&(i.temp[me.j.notationProvider]=e.cell.column.temp[me.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Cs.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){vs.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const so="#333333",ao="rgba(60, 177, 115, 0.1)",lo="rgba(240, 240, 240, 0.5)",co="rgba(100, 100, 100, 0.3)";class uo{constructor(e=po.DEFAULT_TRACK_HEIGHT,t=po.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class ho extends uo{constructor(e=new Map,t=po.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,po.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=He.o.NUCLEOTIDE;break;default:t=He.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,Ai.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=ao,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=lo,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=co,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class mo extends uo{constructor(e,t=po.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,po.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=ao,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=lo,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=co,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=so,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const po={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35,ANNOTATION_TRACK_HEIGHT:20},go={BASE:po.DOTTED_CELL_HEIGHT+po.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+po.TITLE_HEIGHT+po.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+po.DEFAULT_TRACK_HEIGHT+po.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+po.DEFAULT_TRACK_HEIGHT+po.TRACK_GAP}};class fo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||go.BASE,sliderHeight:e.sliderHeight||po.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0,dragMode:"none",dragStartWindowPosition:1,dragOccurred:!1},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation"),i=this.getTrack("annotations");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(po.DEFAULT_TRACK_HEIGHT)}),e<go.WITH_TITLE())return;let o=0;i&&(i.setVisible(!0),i.setHeight(po.ANNOTATION_TRACK_HEIGHT),o=po.ANNOTATION_TRACK_HEIGHT+po.TRACK_GAP);const r=go.WITH_WEBLOGO()+o,s=go.WITH_BOTH()+o;if(!(e<r))if(e<s){if(t){t.setVisible(!0);const n=e-r;t.setHeight(po.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>s){const n=e-s;t.setHeight(po.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<r&&t&&t.setVisible(!1),e<s&&n&&n.setVisible(!1))}}drawTrackButtons(){const e=70;if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),n=this.getTrack("weblogo"),i=this.getTrack("annotations"),o=t?.isVisible()??!1,r=n?.isVisible()??!1,s=i?.isVisible()??!1;let a=this.config.width-16;const l=this.config.headerHeight>=go.WITH_TITLE()?(po.TITLE_HEIGHT-14)/2:2;o&&r||(!o&&t&&(a-=e,this.drawTrackButton("conservation","Conservation",a,l,e,14),a-=4),!r&&n&&(a-=e,this.drawTrackButton("weblogo","WebLogo",a,l,e,14),a-=4)),!s&&i&&(a-=e,this.drawTrackButton("annotations","Annotations",a,l,e,14))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=go.WITH_TITLE()?po.TITLE_HEIGHT:0)}snapToTrackHeight(e){const t=this.getTrack("annotations")?po.ANNOTATION_TRACK_HEIGHT+po.TRACK_GAP:0;let n;if("annotations"===e)n=go.WITH_TITLE()+t;else if("weblogo"===e)n=go.WITH_WEBLOGO()+t;else{if("conservation"!==e)return;n=go.WITH_BOTH()+t}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]="annotations"===t})),"annotations"===e?this.userSelectedTracks.annotations=!0:"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(n),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.getTrack("annotations")?po.ANNOTATION_TRACK_HEIGHT+po.TRACK_GAP:0,t=this.tracks.size>0?go.WITH_BOTH()+e:go.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=go.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,po.TITLE_HEIGHT),this.ctx.fillStyle=so,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+po.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof ho&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=go.WITH_TITLE()?po.TITLE_HEIGHT:0,l=this.config.headerHeight-po.SLIDER_HEIGHT-po.DOTTED_CELL_HEIGHT,c=l-po.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[];this.tracks.forEach((e,t)=>{e.isVisible()&&d.push({id:t,track:e})});let m=c;for(const{id:e,track:t}of d){const i=m-t.getHeight();if(n>=i&&n<m){u=e,h=n-i;break}m=i-po.TRACK_GAP}let p=null;if(u){const e=this.tracks.get(u);e&&(p=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==p)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=p,u)){const e=this.tracks.get(u);e instanceof ho&&(e.setHovered(s,p),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||p!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=p,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,p);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=go.WITH_TITLE();l&&po.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-po.SLIDER_HEIGHT,u=c-po.DOTTED_CELL_HEIGHT,h=u-po.TRACK_GAP,d=[],m=[];this.tracks.forEach((e,t)=>{e.isVisible()&&m.push({id:t,track:e})});let p=h;for(const{track:e}of m){const t=e.getHeight(),i=p-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),p=i-po.TRACK_GAP}if(this.drawDottedCells(0,u,n,po.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:po.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+po.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=so,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,po.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,po.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,po.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-po.SLIDER_HEIGHT;return t>n&&t<n+po.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-po.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+po.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.state.isDragging&&"header"===this.state.dragMode?this.eventElement.style.cursor="grabbing":this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)?this.eventElement.style.cursor="pointer":this.isInHeaderArea(e)?this.eventElement.style.cursor="grab":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(this.state.dragOccurred)return;if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=go.WITH_TITLE()?po.TITLE_HEIGHT:0,a=this.config.headerHeight-po.SLIDER_HEIGHT-po.DOTTED_CELL_HEIGHT,l=a-po.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-po.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=go.WITH_TITLE()&&t&&(yo(e.left??0,n,i)||yo(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e);this.isInSliderDraggableArea(e)?(this.state.isDragging=!0,this.state.dragMode="slider",this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()):this.isInHeaderArea(e)&&!this.isInSliderArea(e)&&(this.state.isDragging=!0,this.state.dragMode="header",this.state.dragStartX=t,this.state.dragStartWindowPosition=this.config.windowStartPosition,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;if(this.state.dragOccurred=!0,"slider"===this.state.dragMode)this.handleSliderDrag(n);else if("header"===this.state.dragMode){const e=n-this.state.dragStartX,t=Math.round(e/this.config.positionWidth),i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-i+1;this.config.windowStartPosition=Math.max(1,Math.min(o,this.state.dragStartWindowPosition-t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1,this.state.dragMode="none",this.state.dragOccurred&&setTimeout(()=>{this.state.dragOccurred=!1},0)}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(this.state.dragOccurred)return;if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(this.isInsideColumnHeaderArea(t,n))this.seqColumn&&(o.shell.o=this.seqColumn);else if(n<this.config.headerHeight-po.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:go.BASE,WITH_TITLE:go.WITH_TITLE(),WITH_WEBLOGO:go.WITH_WEBLOGO(),WITH_BOTH:go.WITH_BOTH()}}}function yo(e,t,n){return e>=t&&e<=n}class bo extends uo{constructor(e,t="Annotations"){super(20,14,t),this.tableCol=e,this.regions=[],this.posList=[],this._cacheVersion=-1,this._rebuildRegions()}hasRegions(){return this._ensureUpToDate(),this.regions.length>0}getRegionAtPosition(e){this._ensureUpToDate();for(const t of this.regions)if(e>=t.startIdx&&e<=t.endIdx)return t;return null}getTooltipContent(e,t){this._ensureUpToDate();const n=this.getRegionAtPosition(e);if(!n)return null;const i=n.sourceScheme??"",o=e<this.posList.length?this.posList[e]:"",s=[],a=document.createElement("b");return a.textContent=n.name,s.push(r.div([a],{style:{fontSize:"13px",marginBottom:"4px"}})),i&&s.push(r.divText(`Scheme: ${i}`,{style:{fontSize:"12px",color:"#555"}})),s.push(r.divText(`Range: ${n.startPos} – ${n.endPos}`,{style:{fontSize:"12px",color:"#555"}})),o&&s.push(r.divText(`Position: ${o}`,{style:{fontSize:"12px",color:"#555"}})),n.description&&s.push(r.divText(n.description,{style:{fontSize:"11px",color:"#888",marginTop:"2px"}})),r.divV(s,{style:{padding:"4px"}})}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible)return;if(this._ensureUpToDate(),0===this.regions.length)return;const l=this.ctx;l.save(),l.beginPath(),l.rect(e,t,n,i),l.clip();const c=o-1,u=c+Math.ceil(n/r)+2;for(const n of this.regions){if(n.endIdx<c||n.startIdx>u)continue;const o=Math.max(n.startIdx,c),s=e+(o-c)*r,a=(Math.min(n.endIdx,u)-o+1)*r;l.fillStyle=n.color,l.globalAlpha=.35,l.fillRect(s,t,a,i),l.globalAlpha=1,l.strokeStyle=n.color,l.globalAlpha=.6,l.lineWidth=1,l.strokeRect(s+.5,t+.5,a-1,i-1),l.globalAlpha=1,l.font="bold 9px Roboto, Roboto Local, sans-serif",a>l.measureText(n.name).width+4&&(l.fillStyle="#333",l.textAlign="center",l.textBaseline="middle",l.fillText(n.name,s+a/2,t+i/2))}l.restore()}_ensureUpToDate(){this._cacheVersion!==this.tableCol.version&&(this._rebuildRegions(),this._cacheVersion=this.tableCol.version)}_rebuildRegions(){this.regions=[];const e=this.tableCol.getTag(pe.gp.annotations);if(!e)return;let t;try{t=JSON.parse(e)}catch{return}if(this.posList=this._getPosList(),0!==this.posList.length)for(const e of t){if(e.category!==xt.eI.Structure)continue;if(null==e.start||null==e.end)continue;const t=this.posList.indexOf(e.start),n=this.posList.indexOf(e.end);t<0||n<0||this.regions.push({name:e.name,color:e.color??this._defaultColor(e),startIdx:t,endIdx:n,startPos:e.start,endPos:e.end,sourceScheme:e.sourceScheme,description:e.description})}}_getPosList(){const e=this.tableCol.getTag(pe.gp.positionNames);return e?e.split(", "):[]}_defaultColor(e){if(e.name.startsWith("CDR")){const t=parseInt(e.name.replace("CDR",""))-1;return xt.D5.structure.CDR[t%xt.D5.structure.CDR.length]}if(e.name.startsWith("FR")){const t=parseInt(e.name.replace("FR",""))-1;return xt.D5.structure.FR[t%xt.D5.structure.FR.length]}return"#90CAF9"}}class vo{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){vo.conservationCache=new s.LruCache(100),vo.webLogoCache=new s.LruCache(100),vo.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return vo.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return vo.conservationCache.getOrCreate(i,()=>{const o=vo.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return vo.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/vo.CHUNK_SIZE)*vo.CHUNK_SIZE,s=Math.ceil(n/vo.CHUNK_SIZE)*vo.CHUNK_SIZE;for(let t=r;t<s;t+=vo.CHUNK_SIZE){const n=Math.min(t+vo.CHUNK_SIZE,i),r=vo.getChunkCacheKey(e.column,t,n),s=vo.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/vo.CHUNK_SIZE)*vo.CHUNK_SIZE,s=Math.ceil(n/vo.CHUNK_SIZE)*vo.CHUNK_SIZE;for(let t=r;t<s;t+=vo.CHUNK_SIZE){const n=Math.min(t+vo.CHUNK_SIZE,i),r=vo.getChunkCacheKey(e.column,t,n),s=vo.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class wo extends ho{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=vo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=vo.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class Co extends mo{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=vo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=vo.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const Ao="__msa-scroller-initialized",So="__msa-scroller-subscription";class xo extends Qi.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return pe.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=$e.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:pe.Hi.HELM})(n)}createCellRendererBack(e,t){const n=vs.properties.maxMonomerLength||4,i=new Eo(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class Eo extends Re.Jy{constructor(e,t,n,i){super(e,t,vs.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Re.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:$e.zS}})}}var Mo,To,Io=n(6520),_o={};_o.styleTagTransform=C(),_o.setAttributes=y(),_o.insert=g().bind(null,"head"),_o.domAPI=m(),_o.insertStyleElement=v(),h()(Io.A,_o),Io.A&&Io.A.locals&&Io.A.locals;class Lo{view=null;libHelper=null;monomerLib=null;collectionNames=[];filteredNames=[];displayedCount=0;cardsContainer=null;loadMoreContainer=null;searchInput=null;currentUser="";collectionsCache=new Map;selectedCollections=new Set;cardElements=new Map;handler=new Un;static VIEW_NAME="Monomer Collections";async init(){this.libHelper=await yn.getInstance(),await this.libHelper.awaitLoaded(),this.monomerLib=this.libHelper.getMonomerLib(),this.currentUser=s.User.current().login,this.view=s.View.create(),this.view.name=Lo.VIEW_NAME,this.view._mcView=this;const e=r.icons.add(()=>this.showAddCollectionDialog(),"Create new monomer collection"),t=r.iconFA("sync",()=>this.refresh(),"Refresh collections");return this.view.setRibbonPanels([[e,t]]),this.view.root.addEventListener("contextmenu",e=>{const t=e.target;if(t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card"))return;e.preventDefault();const n=s.Menu.popup();n.item("New Collection...",()=>this.showAddCollectionDialog()),n.item("Refresh",()=>this.refresh()),n.show()}),this.view.root.addEventListener("click",e=>{const t=e.target;t.closest(".monomer-collection-card")||t.closest(".monomer-collection-add-card")||this.clearSelection()}),this.view.root.tabIndex=0,this.view.root.addEventListener("keydown",e=>{"Escape"===e.key&&this.clearSelection()}),await this.buildContent(),this.view}async buildContent(){if(!this.view)return;this.view.root.innerHTML="";const e=r.div([],{classes:"monomer-collections-view"});this.searchInput=r.input.string("Monomer Collections",{value:"",placeholder:"Search by name or tag..."}),this.searchInput.root.classList.add("monomer-collections-search");const t=this.searchInput.input;t.style.width="100%",t.style.marginBottom="12px";let n=null;t.addEventListener("input",()=>{n&&clearTimeout(n),n=setTimeout(()=>this.applyFilter(),250)}),this.cardsContainer=r.div([],{classes:"monomer-collections-grid"}),this.loadMoreContainer=r.div([],{classes:"monomer-collections-load-more"}),e.appendChild(this.searchInput.root),e.appendChild(this.cardsContainer),e.appendChild(this.loadMoreContainer),this.view.root.appendChild(e),await this.loadCollections()}async loadCollections(){try{this.collectionNames=await this.libHelper.listMonomerCollections()}catch(e){vs.logger.error(`Error listing monomer collections: ${e instanceof Error?e.message:e.toString()}`),o.shell.error("Error loading monomer collections"),this.collectionNames=[]}this.collectionsCache.clear();for(const e of this.collectionNames)this.libHelper.readMonomerCollection(e).then(t=>{this.collectionsCache.set(e,t)}).catch(()=>{});this.applyFilter()}applyFilter(){const e=(this.searchInput?.value??"").trim().toLowerCase();this.filteredNames=e?this.collectionNames.filter(t=>{if(t.replace(/\.json$/i,"").toLowerCase().includes(e))return!0;const n=this.collectionsCache.get(t);return!!n?.tags?.some(t=>t.toLowerCase().includes(e))}):[...this.collectionNames],this.displayedCount=0,this.cardsContainer.innerHTML="",this.cardElements.clear(),this.showNextPage()}showNextPage(){const e=Math.min(this.displayedCount+19,this.filteredNames.length);for(let t=this.displayedCount;t<e;t++){const e=this.createCollectionCard(this.filteredNames[t]);this.cardsContainer.appendChild(e),this.cardElements.set(this.filteredNames[t],e)}this.displayedCount=e;const t=this.cardsContainer.querySelector(".monomer-collection-add-card");t&&t.remove(),this.cardsContainer.appendChild(this.createAddCard());const n=this.cardsContainer.querySelector(".monomer-collection-empty-state");if(n&&n.remove(),0===this.filteredNames.length){const e=0===this.collectionNames.length?'No monomer collections found. Click "+" to create one.':"No collections match your search.",t=r.div([r.divText(e)],{classes:"monomer-collection-empty-state"});this.cardsContainer.prepend(t)}if(this.loadMoreContainer.innerHTML="",this.displayedCount<this.filteredNames.length){const e=this.filteredNames.length-this.displayedCount,t=r.button(`Load more (${e} remaining)`,()=>this.showNextPage());this.loadMoreContainer.appendChild(t)}}createCollectionCard(e){const t=e.replace(/\.json$/i,""),n=r.div([t],{classes:"monomer-collection-card-title"});r.tooltip.bind(n,t);const i=r.div([n],{classes:"monomer-collection-card-header"}),a=r.div([],{classes:"monomer-collection-card-body"}),l=r.div([],{classes:"monomer-collection-card-actions"}),c=r.div([i,a,l],{classes:"monomer-collection-card"});c.dataset.collectionName=e,this.selectedCollections.has(e)&&c.classList.add("monomer-collection-card-selected"),c.addEventListener("click",t=>{const n=t.target;n.closest(".monomer-collection-card-actions")||n.closest(".monomer-collection-tag")||(t.stopPropagation(),this.handleCardClick(e,t.ctrlKey||t.metaKey))}),c.addEventListener("contextmenu",t=>{t.preventDefault(),t.stopPropagation(),this.selectedCollections.has(e)||this.handleCardClick(e,!1),this.showCardContextMenu(t)});const u=async()=>{const t=await this.libHelper.readMonomerCollection(e);if(this.collectionsCache.set(e,t),t.description){const e=r.div([t.description],{classes:"monomer-collection-card-description"});r.tooltip.bind(e,t.description),i.appendChild(e)}if(t.tags&&t.tags.length>0){const e=r.div([],{classes:"monomer-collection-card-tags"});for(const n of t.tags){const t=r.div([n],{classes:"monomer-collection-card-tag"});e.appendChild(t)}i.appendChild(e)}const n=[];if(t.updatedBy&&n.push(`by ${t.updatedBy}`),t.updatedOn)try{n.push(new Date(t.updatedOn).toLocaleDateString())}catch{}n.length>0&&i.appendChild(r.div([n.join(" | ")],{classes:"monomer-collection-card-meta"}));const a=r.div([],{classes:"monomer-collection-tags"}),c=t.monomerSymbols??[];for(const e of c){const t=r.div([e],{classes:"monomer-collection-tag"});t.addEventListener("mouseenter",()=>{if(this.monomerLib){const n=this.getMonomerTooltipSafe(e);if(n){const e=t.getBoundingClientRect();r.tooltip.show(n,e.left,e.bottom+4)}}}),t.addEventListener("mouseleave",()=>r.tooltip.hide()),t.addEventListener("click",t=>{t.stopPropagation(),o.shell.o=s.SemanticValue.fromValueType(e,Ge.uF.MONOMER)}),a.appendChild(t)}const u=r.divText(`${c.length} monomer(s)`,{style:{fontSize:"11px",color:"var(--grey-4)",marginBottom:"6px"}}),h=r.divV([u,a]),d=t.updatedBy===this.currentUser,m=r.button("Edit",()=>{d&&this.showEditCollectionDialog(e,t)}),p=r.button("Delete",()=>{d&&this.confirmDeleteCollection(e)});if(!d){for(const e of[m,p])e.style.opacity="0.4",e.style.cursor="default";r.tooltip.bind(m,"Only the author can edit"),r.tooltip.bind(p,"Only the author can delete")}return l.appendChild(m),l.appendChild(p),h};return a.appendChild(r.wait(()=>u())),c}handleCardClick(e,t){t?this.selectedCollections.has(e)?this.selectedCollections.delete(e):this.selectedCollections.add(e):(this.selectedCollections.clear(),this.selectedCollections.add(e)),this.updateCardSelectionStyles(),this.setCurrentObject()}clearSelection(){this.selectedCollections.clear(),this.updateCardSelectionStyles()}updateCardSelectionStyles(){for(const[e,t]of this.cardElements)this.selectedCollections.has(e)?t.classList.add("monomer-collection-card-selected"):t.classList.remove("monomer-collection-card-selected")}async setCurrentObject(){const e=[...this.selectedCollections];if(0===e.length)return;const t=[];for(const n of e){let e=this.collectionsCache.get(n);if(!e)try{e=await this.libHelper.readMonomerCollection(n)}catch{continue}t.push({name:n,displayName:n.replace(/\.json$/i,""),data:e})}1===t.length?o.shell.o=t[0]:t.length>1&&(o.shell.o=t)}showCardContextMenu(e){const t=s.Menu.popup(),n=[...this.selectedCollections];if(n.length<=1&&n.length>0){const e=n[0],i=this.collectionsCache.get(e);if(i){const n={name:e,displayName:e.replace(/\.json$/i,""),data:i};Un.buildContextMenu(t,n,this.handler)}}else if(n.length>1){const e=n.map(e=>{const t=this.collectionsCache.get(e);return t?{name:e,displayName:e.replace(/\.json$/i,""),data:t}:null}).filter(e=>null!==e);e.length>0&&Un.buildMultiContextMenu(t,e,this.handler)}t.show()}getMonomerTooltipSafe(e){if(!this.monomerLib)return null;const t=[He.o.AA,He.o.NUCLEOTIDE,He.o.CHEM,He.o.BLOB];for(const n of t)try{if(this.monomerLib.getWebEditorMonomer(n,e))return this.monomerLib.getTooltip(n,e)}catch(e){}return null}createAddCard(){const e=r.iconFA("plus",()=>{},"");e.style.fontSize="32px",e.style.marginBottom="8px";const t=r.span(["New Collection"]),n=r.div([e,t],{classes:"monomer-collection-add-card-content"}),i=r.div([n],{classes:"monomer-collection-add-card"});return i.addEventListener("click",()=>this.showAddCollectionDialog()),i}showAddCollectionDialog(){const e=r.input.string("Name",{nullable:!1,placeholder:"Enter collection name"}),t=r.input.string("Description",{nullable:!0,placeholder:"Optional description"}),n=r.input.string("Tags",{nullable:!0,placeholder:"Comma-separated tags"}),i=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),s=new Wn(this.monomerLib,i.value,[],this.libHelper);i.onChanged.subscribe(()=>{s.setPolymerType(i.value)}),r.dialog({title:"New Monomer Collection"}).add(r.divV([e,t,n,i,r.element("hr"),s.root])).onOK(async()=>{const i=e.value?.trim();if(!i)return void o.shell.warning("Collection name is required");const r=s.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const a=No(n.value);try{await this.libHelper.addOrUpdateMonomerCollection(i,r,t.value??void 0,a.length>0?a:void 0),o.shell.info(`Collection "${i}" created successfully`),await this.refresh()}catch(e){o.shell.error("Error creating collection"),vs.logger.error(`Error creating collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",s.focus()}editCollectionPublic(e,t){this.showEditCollectionDialog(e,t)}showEditCollectionDialog(e,t){const n=e.replace(/\.json$/i,""),i=r.input.string("Name",{value:n,nullable:!1}),s=r.input.string("Description",{value:t.description??"",nullable:!0}),a=r.input.string("Tags",{value:(t.tags??[]).join(", "),nullable:!0,placeholder:"Comma-separated tags"}),l=r.input.choice("Polymer Type",{items:["PEPTIDE","RNA","CHEM"],value:"PEPTIDE",nullable:!1}),c=new Wn(this.monomerLib,l.value,[...t.monomerSymbols??[]],this.libHelper);l.onChanged.subscribe(()=>{c.setPolymerType(l.value)}),r.dialog({title:`Edit Collection: ${n}`}).add(r.divV([i,s,a,l,r.element("hr"),c.root])).onOK(async()=>{const t=i.value?.trim();if(!t)return void o.shell.warning("Collection name is required");const r=c.getSelectedMonomers();if(0===r.length)return void o.shell.warning("Please select at least one monomer");const l=No(a.value);try{t!==n&&await this.libHelper.deleteMonomerCollection(e),await this.libHelper.addOrUpdateMonomerCollection(t,r,s.value??void 0,l.length>0?l:void 0),o.shell.info(`Collection "${t}" saved successfully`),await this.refresh()}catch(e){o.shell.error("Error saving collection"),vs.logger.error(`Error saving collection: ${e instanceof Error?e.message:e.toString()}`)}}).show({resizable:!0}).root.style.width="550px",c.focus()}confirmDeleteCollection(e){const t=e.replace(/\.json$/i,"");r.dialog({title:"Delete Collection"}).add(r.divText(`Are you sure you want to delete the collection "${t}"?`)).onOK(async()=>{try{await this.libHelper.deleteMonomerCollection(e),o.shell.info(`Collection "${t}" deleted`),await this.refresh()}catch(e){o.shell.error("Error deleting collection"),vs.logger.error(`Error deleting collection: ${e instanceof Error?e.message:e.toString()}`)}}).show()}async refresh(){this.selectedCollections.clear(),await this.loadCollections()}}function No(e){return e?e.split(",").map(e=>e.trim()).filter(e=>e.length>0):[]}class Po{colInput;constructor(e,t){const n=t.filter;this.colInput=r.input.column(e,{...t,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE&&(!n||n(e))});const i=r.iconFA("cut",()=>this.onRegionIconClick(),"Extract a region from the sequence");this.colInput.addOptions(i)}static create(e,t){return new Po(e,t)}get root(){return this.colInput.root}get value(){return this.colInput.value}set value(e){this.colInput.value=e}get inputBase(){return this.colInput}onRegionIconClick(){const e=this.colInput.value;e?function(e,t){const n=vs.seqHelper.getSeqHandler(e),i=r.input.string("Name",{value:""}),a=r.input.choice("Start Position",{value:n.posList[0],items:n.posList,onValueChanged:()=>h()}),l=r.input.choice("End Position",{value:n.posList[n.posList.length-1],items:n.posList,onValueChanged:()=>h()});let c=null;const u=()=>c?`${e.name}(${c}): ${a.value}-${l.value}`:`${e.name}:${a.value}-${l.value}`,h=()=>{i.value||i.input.setAttribute("placeholder",u())};h();const d=function(e,t,n,i){let o=null;const s=e.getTag(ue.gp.annotations);if(s)try{const e=JSON.parse(s).filter(e=>e.category===xt.eI.Structure&&e.start&&e.end);e.length>0&&(o=e.map(e=>({name:e.name,start:e.start,end:e.end})))}catch{}if(!o){const t=e.getTag(ue.gp.regions);if(t)try{o=JSON.parse(t)}catch{}}if(!o||0===o.length)return null;const a=["",...o.map(e=>`${e.name}: ${e.start}-${e.end}`)];return r.input.choice("Region",{value:"",items:a,onValueChanged:e=>{if(!e)return void i?.(null);const r=o.find(t=>`${t.name}: ${t.start}-${t.end}`===e);r&&(t.value=r.start,n.value=r.end,i?.(r.name))}})}(e,a,l,e=>{c=e,h()}),m=[];d&&m.push(d),m.push(i,a,l);const p=r.dialog({title:"Get Region"}).add(r.inputs(m)).onOK(()=>{const n=s.TaskBarProgressIndicator.create("Getting region...");try{const n=i.value||u(),o=Ti(e,a.value,l.value,n);e.dataFrame.columns.add(o),o.setTag(s.TAGS.CELL_RENDERER,"sequence"),t?.(o)}catch(e){o.shell.error(e.toString())}finally{n.close()}});p.show()}(e,e=>{this.colInput.value=e}):o.shell.warning("Select a macromolecule column first.")}}async function Ro(){return await Cs.getMonomerLibHelper()}async function $o(){await Cs.initBio()}function Oo(e){return Cs.sequenceTooltip(e)}async function ko(e){return await Cs.standardiseMonomerLibrary(e)}async function Ho(e,t,n){await Cs.matchWithMonomerLibrary(e,t,n)}function Bo(){return Cs.getBioLib()}function Fo(e){return Cs.getSeqHandler(e)}function Do(e){return Cs.getRegionPanel(e)}async function Go(e){return await Cs.libraryPanel(e)}function Vo(e){Cs.GetRegionEditor(e)}function qo(e){Cs.SplitToMonomersEditor(e)}function jo(e){Cs.SequenceSpaceEditor(e)}function Wo(e){Cs.SeqActivityCliffsEditor(e)}function Uo(){return Cs.customSequenceCellRenderer()}function zo(){return Cs.fastaSequenceCellRenderer()}function Yo(){return Cs.separatorSequenceCellRenderer()}function Ko(){return Cs.bilnSequenceCellRenderer()}function Zo(e,t,n){return Cs.refineNotationProviderForBiln(e,t,n)}function Xo(e){return Cs.macroMolColumnPropertyPanel(e)}function Jo(e){return Cs.compositionAnalysisWidget(e)}function Qo(e){return Cs.monomerInfoPanel(e)}function er(){return Cs.macromoleculeDifferenceCellRenderer()}function tr(e,t,n,i,o){return Cs.sequenceAlignment(e,t,n,i,o)}function nr(){return Cs.webLogoViewer()}function ir(){return Cs.vdRegionsViewer()}function or(e,t,n,i){return Cs.getRegion(e,t,n,i)}async function rr(e,t,n,i,o){await Cs.getRegionTopMenu(e,t,n,i,o)}function sr(){Cs.applyNumberingScheme()}function ar(){Cs.scanLiabilities()}function lr(){Cs.manageAnnotations()}function cr(e,t){return Cs.sequenceColumnInput(e,t)}async function ur(e,t,n,i,o,r,s,a,l){return await Cs.activityCliffs(e,t,n,i,o,r,s,a,l)}async function hr(e){await Cs.seqActivityCliffsInitFunction(e)}async function dr(e,t,n,i,o,r,s,a,l){await Cs.seqActivityCliffsTransform(e,t,n,i,o,r,s,a,l)}async function mr(e,t,n,i,o){return await Cs.macromoleculePreprocessingFunction(e,t,n,i,o)}async function pr(e,t){return await Cs.helmPreprocessingFunction(e,t)}async function gr(e,t,n,i,o,r,s,a,l){return await Cs.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function fr(e,t,n,i,o,r,s,a,l){return await Cs.sequenceSpaceTransform(e,t,n,i,o,r,s,a,l)}async function yr(e,t){await Cs.moleculesToHelmTopMenu(e,t)}async function br(e){return await Cs.moleculeToHelmSingle(e)}async function vr(e,t,n,i){await Cs.toAtomicLevel(e,t,n,i)}async function wr(e){await Cs.toAtomicLevelAction(e)}async function Cr(e){return await Cs.toAtomicLevelPanel(e)}async function Ar(e){return await Cs.toAtomicLevelSingleSeq(e)}async function Sr(e){return await Cs.sequence3dStructureWidget(e)}function xr(){Cs.multipleSequenceAlignmentDialog()}async function Er(e,t,n){return await Cs.alignSequences(e,t,n)}async function Mr(){return await Cs.compositionAnalysis()}function Tr(e){return Cs.importFasta(e)}function Ir(e){return Cs.importBam(e)}function _r(){Cs.convertDialog()}function Lr(e){Cs.convertColumnAction(e)}function Nr(){return Cs.monomerCellRenderer()}async function Pr(e){return await Cs.testDetectMacromolecule(e)}async function Rr(e,t){return await Cs.splitToMonomersTopMenu(e,t)}function $r(e){return Cs.getHelmMonomers(e)}function Or(){return Cs.similaritySearchViewer()}function kr(){return Cs.similaritySearchTopMenu()}function Hr(){return Cs.diversitySearchViewer()}function Br(){return Cs.diversitySearchTopMenu()}function Fr(e){Cs.searchSubsequenceEditor(e)}function Dr(e){Cs.SubsequenceSearchTopMenu(e)}async function Gr(e,t,n){return await Cs.sequenceIdentityScoring(e,t,n)}async function Vr(e,t,n){return await Cs.sequenceSimilarityScoring(e,t,n)}async function qr(){await Cs.manageMonomerLibraries()}async function jr(){await Cs.manageLibrariesView()}async function Wr(){await Cs.manageMonomersView()}async function Ur(e){return await Cs.manageMonomerLibrariesView(e)}async function zr(e){await Cs.manageMonomerLibrariesViewTreeBrowser(e)}async function Yr(){return await Cs.monomerCollectionsApp()}function Kr(){Cs.saveAsFasta()}function Zr(){return Cs.bioSubstructureFilter()}function Xr(){return Cs.bioSubstructureFilterTest()}async function Jr(){await Cs.webLogoLargeApp()}async function Qr(){await Cs.webLogoAggApp()}async function es(){await Cs.getRegionApp()}async function ts(){await Cs.getRegionHelmApp()}function ns(){Cs.longSeqTableSeparator()}function is(){Cs.longSeqTableFasta()}function os(){Cs.longSeqTableHelm()}function rs(e,t){Cs.addCopyMenu(e,t)}async function ss(){await Cs.demoBioSimilarityDiversity()}async function as(){await Cs.demoBioSequenceSpace()}async function ls(){await Cs.demoBioActivityCliffs()}async function cs(){await Cs.demoBioAtomicLevel()}async function us(e){await Cs.sdfToJsonLib(e)}async function hs(e,t){return await Cs.seq2atomic(e,t)}async function ds(e,t){return await Cs.seqIdentity(e,t)}async function ms(e,t,n){await Cs.detectMacromoleculeProbe(e,t,n)}async function ps(){return await Cs.getSeqHelper()}async function gs(e,t,n){return await Cs.getMolFromHelm(e,t,n)}!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(Mo||(Mo={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.monomerInfoPanel=async function(e){return await o.functions.call("Bio:MonomerInfoPanel",{monomerSv:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.applyNumberingScheme=async function(){return await o.functions.call("Bio:ApplyNumberingScheme",{})},e.scanLiabilities=async function(){return await o.functions.call("Bio:ScanLiabilities",{})},e.manageAnnotations=async function(){return await o.functions.call("Bio:ManageAnnotations",{})},e.sequenceColumnInput=async function(e,t){return await o.functions.call("Bio:SequenceColumnInput",{name:e,options:t})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.seqActivityCliffsInitFunction=async function(e){return await o.functions.call("Bio:SeqActivityCliffsInitFunction",{sp:e})},e.seqActivityCliffsTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SeqActivityCliffsTransform",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,options:a,isDemo:l,axesNames:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.sequenceSpaceTransform=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTransform",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,options:s,clusterEmbeddings:a,embedColsNames:l,clusterColName:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesView",{path:e})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.monomerCollectionsApp=async function(){return await o.functions.call("Bio:MonomerCollectionsApp",{})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(To||(To={}));var fs=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},ys=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},bs=function(e,t){return function(n,i){t(n,i,e)}};const vs=new Ci;let ws=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class Cs{static async getMonomerLibHelper(){return await yn.getInstance()}static async initBio(){null==ws&&(ws=async function(){const e="Bio: _package.initBio()";vs.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Le.j)(),i=await vs.getProperties(),r=new wi(i);vs.properties=r;const a=await yn.getInstance(),l=await(0,_e.u)();l.explicit&&(l.explicit=[],await(0,_e.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();vs.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new oo(a,n);vs.completeInit(m,u,h,n),s.ObjectHandler.register(new Un),vs.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[So]||(t.temp[So]=[]);let i=t.temp[So];i.forEach(e=>e.unsubscribe()),t.temp[So]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[Ao];i.temp[Ao]=!0;let l=null;try{l=vs.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>Re.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],v=l.splitter(b),w=v?v.length:30,C=e.getTag(ue.gp.annotations)?24:0,A={WITH_TITLE:58,WITH_WEBLOGO:107+C,WITH_BOTH:156+C};let S;S=e.length>1e5||w<50?A.WITH_TITLE+C:e.length>5e4?A.WITH_WEBLOGO:A.WITH_BOTH;let x=null,E=null;const M=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{vo.clearAllCaches(),x&&(x.resetViewportTracking(),x.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(M);const T=o=>{const c=[],h=new bo(e,"Annotations");h.hasRegions()&&c.push({id:"annotations",track:h,priority:0});const g=new wo(l,w,45,"WebLogo");x=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:1});const f=new Co(l,w,45,"default","Conservation");E=f,c.push({id:"conservation",track:f,priority:2});const y=new fo({canvas:t.overlay,headerHeight:S,totalPositions:w+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<A.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);y.setupTooltipHandling(),c.sort((e,t)=>e.priority-t.priority),c.forEach(({id:e,track:t})=>{y.addTrack(e,t)}),y.setSelectionData(n,e,l),w>50&&!a&&(t.props.colHeaderHeight=S,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>y.detach()});const b=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==b?.dart)return;const i=t.bounds;if(!i)return;y.headerHeight=i.height;const o=p();y.positionWidth=o+8;const r=d();y.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();T(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await ws}static sequenceTooltip(e){const t=new Ei(e,vs.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Mn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await Mn(l);c.forEach((e,t)=>{e.lib=l[t].lib});const{cappedMap:u,uncappedMap:h}=await async function(e,t,n){const i={};for(const t of e){if(!t.smiles)continue;const e={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source??""};i[t.smiles]||(i[t.smiles]=[]),i[t.smiles].push(e)}const o=e.map((e,n)=>({symbol:e.symbol,smiles:Hn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:t[n]?.lib?.source??""})).filter(e=>!!e.smiles&&!e.smiles.includes("[*:")),r=s.Column.fromList(s.COLUMN_TYPE.STRING,"CappedSmiles",o.map(e=>e.smiles));r.semType=s.SEMTYPE.MOLECULE;const a=await n.apply({molecule:r,targetNotation:s.chem.Notation.Smiles});if(!a||a.length!==r.length)throw new Error("Error canonicalizing capped monomer SMILES");const l={},c=a.toList();for(let e=0;e<c.length;e++){const t=c[e];if(!t)continue;o[e].smiles=t;const n=o[e];l[t]||(l[t]=[]),l[t].push(n)}return{cappedMap:l,uncappedMap:i}}(c,l,a),d=await async function(e,t,n){const i=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return On([],t?void 0:e,t?e:void 0)}catch(t){return e}}),o=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesCorrected",i);o.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([o]);const r=await n.apply({molecule:o,targetNotation:s.chem.Notation.Smiles});if(!r||r.length!==o.length)throw new Error("Error canonicalizing molecules");return r.toList()}(e,t,a),m=new Array(d.length).fill(null).map(()=>[]),p=[];for(let e=0;e<d.length;e++){const t=d[e];if(!t)continue;const n=Cn(t,u,h);n.length>0?m[e]=n:p.push(e)}if(p.length>0)try{const{fpMap:e}=await async function(e){const t=Object.keys(e);if(0===t.length)return{fpMap:{},cappedSmilesList:[]};const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",t);n.semType=s.SEMTYPE.MOLECULE;const i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r={};for(let n=0;n<i.length;n++){const o=i.get(n);if(!o)continue;const s=o.toBinaryString(),a=e[t[n]]??[];r[s]||(r[s]=[]),r[s].push(...a)}return{fpMap:r,cappedSmilesList:t}}(u),t=await async function(e,t,n){const i=new Map;if(0===e.length||0===Object.keys(n).length)return i;const r=e.map(e=>t[e]??""),a=r.map(e=>{if(!e)return"";const t=Hn(e,wn);return t!==e?o.chem.convert(t,s.chem.Notation.Unknown,s.chem.Notation.Smiles):e}),l=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMols",r);l.semType=s.SEMTYPE.MOLECULE;const c=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMolsCapped",a);c.semType=s.SEMTYPE.MOLECULE;const[u,h]=await Promise.all([o.functions.call("Chem:getMorganFingerprints",{molColumn:l}),o.functions.call("Chem:getMorganFingerprints",{molColumn:c})]);for(let t=0;t<e.length;t++){const o=e[t],r=u.get(t);if(r){const e=n[r.toBinaryString()];if(e&&e.length>0){i.set(o,e);continue}}const s=h.get(t);if(s){const e=n[s.toBinaryString()];e&&e.length>0&&i.set(o,e)}}return i}(p,d,e);for(const[e,n]of t)m[e]=n}catch(e){console.warn("Fingerprint fallback matching failed, continuing with SMILES matches only:",e)}const g=e.clone(),f=g.columns.addNewString(g.columns.getUnusedName("Matched monomer symbol")),y=g.columns.addNewString(g.columns.getUnusedName("Matched monomer smiles"));y.semType=s.SEMTYPE.MOLECULE;const b=g.columns.addNewString(g.columns.getUnusedName("Matched monomer source")),v=g.columns.addNewInt(g.columns.getUnusedName("Match count")),w=g.columns.addNewString(g.columns.getUnusedName("Match method"));g.columns.setOrder([t,f.name,y.name,b.name,v.name,w.name]);for(let e=0;e<m.length;e++){const t=m[e];if(0===t.length)continue;const n=An(t),i=Sn(n,r);f.set(e,n.map(e=>e.symbol).join(" | "),!1),y.set(e,n[0].original??n[0].smiles,!1),b.set(e,i,!1),v.set(e,n.length,!1);const o=p.includes(e)?"fingerprint":"exact";w.set(e,o,!1)}return g}(e,t.name,vs.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return vs.monomerLib}static getSeqHandler(e){return vs.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:vs.name,name:t});if(1!==n.length)throw new Error(`Package '${vs.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new Li(i,vs.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Yn()(e).addClass("d4-link-action"),e.onclick=async()=>await ei(),new s.Widget(e)}()}static GetRegionEditor(e){try{new Li(e,vs.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),vs.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new pi;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new P({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Ce({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new je}static fastaSequenceCellRenderer(){return new je}static separatorSequenceCellRenderer(){return new je}static bilnSequenceCellRenderer(){return new je}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[me.j.notationProvider]=new xo(n,vs.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let i=vs.properties?vs.properties.maxMonomerLength:4;if(Pe.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Pe.gp.maxMonomerLength));i=isNaN(t)?i:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);i=isNaN(t)?i:t}const o=r.input.int("Max Monomer Length",{value:i,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{o.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let a=vs.properties?vs.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(a=e.temp[".mm.cellRenderer.fontSize"]);const l=r.input.int("Font Size",{value:a,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),c=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),u=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),d=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let m=null;e.meta.units!==ue.Hi.HELM&&(m=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[l,o,c,h,u,d];m&&p.push(m);const g=r.inputs(p),f=(0,St.Ln)(e),y=r.divV([]);if(f.length>0){const t=e.getTag(ue.gp.numberingScheme),i=f.filter(e=>e.category===xt.eI.Structure),o=f.filter(e=>e.category===xt.eI.Liability);if(t&&y.append(r.divText(`Numbering: ${t}`,{style:{fontSize:"12px",marginBottom:"4px"}})),i.length>0){const e=i.map(e=>e.name).join(", ");y.append(r.divText(`Regions: ${e}`,{style:{fontSize:"12px",marginBottom:"4px"}}))}if(o.length>0){const e=o.reduce((e,t)=>{const n=t.description?.match(/\((\d+) hits\)/);return e+(n?parseInt(n[1]):0)},0);y.append(r.divText(`Liabilities: ${o.length} rules (${e} hits)`,{style:{fontSize:"12px",marginBottom:"4px"}}))}const s=r.button("Manage",()=>{n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}),a=r.button("Clear All",()=>{(0,St.OW)(e.dataFrame,e),e.dataFrame.fireValuesChanged()});y.append(r.divH([s,a],{style:{gap:"4px",marginTop:"4px"}}))}else{y.append(r.divText("No annotations",{style:{fontSize:"12px",color:"#888"}}));const e=r.button("Scan Liabilities",()=>{n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}),t=r.button("Apply Numbering",()=>{n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())});y.append(r.divH([e,t],{style:{gap:"4px",marginTop:"4px"}}))}const b=r.accordion();return b.addPane("Renderer Settings",()=>g),b.addPane("Annotations",()=>y),new s.Widget(b.root)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?He.o.NUCLEOTIDE:He.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===He.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,$e.MD)(n)}});const m=(0,Ai.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,vs.monomerLib,vs.seqHelper)}static monomerInfoPanel(e){return function(e,t){const n=e.value;if(!n)return new s.Widget(r.divText("No monomer value."));const i=function(e){try{const t=e.cell?.column;if(t)return t.temp[pe.sc]??null}catch{}return null}(e),o=(i?i.canonicalize(n):n).split(pe.ot).map(e=>e.trim()).filter(e=>e.length>0).map(e=>({symbol:e,monomer:t.getMonomer(null,e)})).filter(e=>null!==e.monomer);if(0===o.length)return new s.Widget(r.divText(`Monomer '${n}' not found in the library.`));const a=r.accordion("Monomer");if(1===o.length){const e=o[0].monomer;a.addPane("Details",()=>Dn(e),!0),a.addPane("Molecule",()=>Gn(e),!0)}else for(const{symbol:e,monomer:t}of o)a.addPane(e,()=>r.divV([Dn(t),r.element("hr"),Gn(t)]),!0);return new s.Widget(a.root)}(e,vs.monomerLib)}static macromoleculeDifferenceCellRenderer(){return new Ue}static sequenceAlignment(e,t,n,i,o){const r=new lt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new et.oP}static vdRegionsViewer(){return new rt}static getRegion(e,t,n,i){return Ti(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=Ti(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static applyNumberingScheme(){n.e(282).then(n.bind(n,1282)).then(e=>e.showNumberingSchemeDialog())}static scanLiabilities(){n.e(422).then(n.bind(n,9422)).then(e=>e.showLiabilityScannerDialog())}static manageAnnotations(){n.e(287).then(n.bind(n,9287)).then(e=>e.showAnnotationManagerDialog())}static sequenceColumnInput(e,t){return Po.create(e,t)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ui.V)(t,"Activity Cliffs"))return;const p=c===l.c.UMAP?2e5:2e4,g=c===l.c.UMAP?5e3:2e3;if(e.rowCount>p)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${p}`);const f=Ee(e),y=async()=>{await s.Func.find({name:"seqActivityCliffsTransform"})[0].prepare({table:e,molecules:t,activities:n,similarity:i,methodName:c,similarityMetric:u,options:JSON.stringify(d),isDemo:m,axesNames:f}).call(void 0,void 0,{processed:!1});const r=o.shell.tv,a=`Molecules: ${t.name}, activities: ${n.name}, method: ${c}, ${d?`options: ${JSON.stringify(d)},`:""} similarity: ${u}, similarity cutoff: ${i}`;r.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:f[0],yColumnName:f[1],color:n.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:"Activity cliffs",initializationFunction:"seqActivityCliffsInitFunction",description:a,descriptionVisibilityMode:"Never"})},b=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");try{e.rowCount>g&&!d?.[a.vb]?await new Promise((e,t)=>{r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{y().then(()=>e()).catch(e=>t(e))}).onCancel(()=>{e()}).show()}):await y()}catch(e){const[t,n]=(0,ve.AP)(e);throw vs.logger.error(t,void 0,n),e}finally{b.close()}}static async seqActivityCliffsInitFunction(e){const t=e.dataFrame.getTag("seqActivityCliffsParams");if(!t)return void o.shell.error("Sequence activity cliffs parameters not found in table tags");const n=JSON.parse(t),i=e.dataFrame.col(n.seqColName),r=e.dataFrame.col(n.activityColName),a=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],l=await a.apply({col:i,metric:n.similarityMetric}),c=[e.getOptions().look.xColumnName,e.getOptions().look.yColumnName],u={units:i.meta.units,aligned:i.getTag(ue.gp.aligned),separator:i.getTag(ue.gp.separator),alphabet:i.getTag(ue.gp.alphabet)};await le(e,e.dataFrame,i,l,r,c,n.similarity,n.similarityMetric,n.options??{},s.SEMTYPE.MACROMOLECULE,u,ht,dt,ft,void 0,n.isDemo)}static async seqActivityCliffsTransform(e,t,i,o,r,a,l,c,u){await e.meta.detectSemanticTypes();const h=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];u||(u=Ee(e)),await async function(e,t,i,o,r,s,a,l){const c=l.inputs,u=await l.apply({[c[0].name]:t,[c[1].name]:r,...a.preprocessingFuncArgs??{}});let h=[];if(s===L){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([u.entries],o,[1],"MANHATTAN",[r],[u.options??{}],a?.maxIterations??5,a.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),h=[t.embedX,t.embedY]}else h=await W([u.entries],s,[r],[1],"MANHATTAN",{...a,distanceFnArgs:[u.options??{}]});if(h.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<h.length;++t)e.columns.addNewFloat(i[t]).init(e=>h[t][e])}(e,t,u,o,a,r,JSON.parse(l??"{}"),h);const d={seqColName:t.name,activityColName:i.name,similarityMetric:a,similarity:o,options:l??{},isDemo:c};e.setTag("seqActivityCliffsParams",JSON.stringify(d))}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ct(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ut.BQ)(e,vs.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=D.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,a,l,c,u){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ui.V)(t,"Sequence Space"))return;const h=e.columns.getUnusedName("Cluster (DBSCAN)"),d=Ee(e);let m;if(await s.Func.find({name:"sequenceSpaceTransform"})[0].prepare({table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:!1,options:JSON.stringify(l),clusterEmbeddings:c,embedColsNames:d,clusterColName:h}).call(void 0,void 0,{processed:!1}),r){m=o.shell.tv.scatterPlot({x:d[0],y:d[1],title:"Sequence space"});const e=`Molecules column: ${t.name}, method: ${n}, ${l?`options: ${JSON.stringify(l)},`:""} similarity: ${i}`;m.setOptions({description:e,descriptionVisibilityMode:"Never"}),c&&(m.props.colorColumnName=h)}return m}static async sequenceSpaceTransform(e,t,n,i,r,l,c,u,h){await e.meta.detectSemanticTypes();const d=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],m=JSON.parse(l??"{}"),p=o.shell.tv?.dataFrame==e?o.shell.tv:void 0;return await Te(e,[t],n,[i],[1],[d],"MANHATTAN",r,c??!1,{...m,preprocessingFuncArgs:[m.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:m?.[a.vb],tableView:p,embedColsNames:u,clusterColName:h})}static async moleculesToHelmTopMenu(e,t){const n=vs.monomerLib,i=JSON.stringify(n.toJSON());await Mo.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=ue.Hi.HELM,o.semType=s.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await Cs.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await ws;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??vs.monomerLib,r=vs.seqHelper,s=vs.rdKitModule;await(0,Ni.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await ro(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){vs.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await ro(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await ro(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=Oi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,di.D)({},vs.seqHelper).catch(e=>{const[t,n]=(0,ve.AP)(e);if(e instanceof hi.Ap)return o.shell.warning(e.element),void vs.logger.warning(t);o.shell.error(t),vs.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,di.D)({col:e,clustersCol:t,...n},vs.seqHelper)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(vs.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,ui.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>vs.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Ne.me)()[0];(0,At.C)(e,vs.seqHelper)}static convertColumnAction(e){(0,At.C)(e,vs.seqHelper)}static monomerCellRenderer(){return new bi}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await s.delay(10),!(0,ui.V)(t,"Sequence space"))return e;const n=ge(t,vs.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ge.uF.MONOMER,e.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ge.uF.MONOMER,o.setTag(pe.gp.alphabet,t.getTag(pe.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return vs.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new wt(vs.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Ct(vs.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Ne.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,vs.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=vs.seqHelper;return Pi(e,t,n,fe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=vs.seqHelper;return Pi(e,t,n,fe.SIMILARITY,i)}static async manageMonomerLibraries(){ei()}static async manageLibrariesView(){await ti()}static async manageMonomersView(){const e=await In.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(e){const t=await ti(!1);return t.parentCall=o.functions.getCurrentCall(),t}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await yn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await In.getInstance();(await e.getViewRoot(t,!0)).parentCall=o.functions.getCurrentCall(),e.resetCurrentRowFollowing()})})}static async monomerCollectionsApp(){return await async function(e=!0){if(e){const e=Array.from(o.shell.views).find(e=>e.name===Lo.VIEW_NAME);if(e)return o.shell.v=e,e}const t=new Lo,n=await t.init();return e&&o.shell.addView(n),n}(!1)}static saveAsFasta(){(0,Vn.TE)()}static bioSubstructureFilter(){return new qn._i(vs.seqHelper,vs.logger)}static bioSubstructureFilterTest(){return new qn._i(vs.seqHelper,vs.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new mi(e,"webLogoLargeApp"),n=await vs.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new mi(e,"webLogoAggApp"),n=await vs.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new _i(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await vs.files.readCsv("samples/HELM_empty_vals.csv"),n=new _i(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,Ie.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(vs.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,Ie.Hx)(vs.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,i){const r=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(r,t=>{const n=e.column,r=e.rowIndex,s=i.getSeqHandler(n),a=t===ue.Hi.SEPARATOR?vs.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")});const s=e.column,a=(0,St.Ln)(s);if(a.length>0&&new Mi.$(s).hasAnnotations()){const e=a.filter(e=>e.category===xt.eI.Structure);if(e.length>0){const r=t.group("Annotations");for(const t of e)t.start&&t.end&&r.item(`Extract ${t.name} as Column`,()=>{n.e(288).then(n.bind(n,9288)).then(e=>{try{e.extractAnnotatedRegion(s.dataFrame,s,t.name,i)}catch(e){o.shell.error(`Failed to extract region: ${e.message??e}`)}})});a.filter(e=>e.category===xt.eI.Liability).length>0&&r.item("Filter: Rows with Liability Hits",()=>{n.e(288).then(n.bind(n,9288)).then(e=>{e.filterByLiabilityHits(s.dataFrame,s)})})}}}(e,t,vs.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await vs.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Ne.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await vs.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Cs.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Yn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),vs.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await vs.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await Cs.toAtomicLevel(e,n,!0,!1),(0,Ne.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Ne.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?Cs.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await Pi(i,n,t,fe.IDENTITY,vs.seqHelper)).get(0)}catch(e){const[t,n]=(0,ve.AP)(e);throw vs.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await s.delay(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Cs.initBio(),vs.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=vs.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,vs.rdKitModule,i);return r.semType=s.SEMTYPE.MOLECULE,r}(0,t,n,vs.monomerLib)}}fs([o.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),ys("design:type",Function),ys("design:paramtypes",[]),ys("design:returntype",Promise)],Cs,"getMonomerLibHelper",null),fs([o.decorators.init({tags:["init"]}),ys("design:type",Function),ys("design:paramtypes",[]),ys("design:returntype",Promise)],Cs,"initBio",null),fs([o.decorators.func({meta:{role:"tooltip"},tags:["tooltip"]}),bs(0,o.decorators.param({options:{semType:"Macromolecule"}})),ys("design:type",Function),ys("design:paramtypes",[s.Column]),ys("design:returntype",s.Widget)],Cs,"sequenceTooltip",null),fs([o.decorators.func({}),ys("design:type",Function),ys("design:paramtypes",[String]),ys("design:returntype",Promise)],Cs,"standardiseMonomerLibrary",null),fs([o.decorators.func({"top-menu":"Bio | Manage | 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c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,p,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=v[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((w[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}(0,s.aZ)(C,b);const A=new Array(y).fill(null);for(const e of w){if(!e||0===e.length)continue;const t=(await m(f.id,e,i,l,u,p)).Alignment;for(const e of t)A[parseInt(e.ID)]=Object.entries(e).filter(e=>!h.includes(e[0])).map(e=>"-"!==e[1]?e[1]:"").join(a.J.SEPARATOR)}const S=o.Column.fromStrings(n,A);return S.meta.units=r.Hi.SEPARATOR,S.setTag(r.gp.separator,a.J.SEPARATOR),S.setTag(r.gp.aligned,"SEQ.MSA"),S.setTag(r.gp.alphabet,r.YI.UN),S.setTag(r.gp.alphabetIsMultichar,"true"),S.semType=o.SEMTYPE.MACROMOLECULE,S}async function m(e,t,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok&&m){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!m){const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();if("pepsea-stderr"in p){const e=p["pepsea-stderr"];s?.warning(e)}return p}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(980);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=function(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=u(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{n5:()=>C,oP:()=>_});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(980);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,A=n(6307),S=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class x{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class E{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,S.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,A.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var T;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(T||(T={}));const I=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(T.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,I.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new E(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=T.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(T.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687(e,t,n){"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),v=n(980);class w extends m.O{seqHelper;emptyProps=new m.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await o.delay(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await o.delay(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends m.O{emptyProps=new m.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new S(this.props.substructure,t,v._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use 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n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=r(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const h=Array.from({length:127},(e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function m(e,t){const n=Object.assign({},t),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const e=o(r.host);if(!1===e.isIPV4){const t=i(e.host);r.host=t.host.toLowerCase(),a=t.isIPV6}else r.host=e.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&r.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(e){r.error=r.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),e&&e.parse&&e.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const p={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(m(e,t),t):"object"==typeof e&&(e=m(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(m(e,i),m(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(m(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(m(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:m};e.exports=p,e.exports.default=p,e.exports.fastUri=p},343(e){"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function r(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:o,serialize:r},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:o,serialize:r},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const o=`${n}:${t.nid||e.nid}`,r=l[o];e.path=void 0,r&&(e=r.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),o=`${n}:${t.nid||i}`,r=l[o];r&&(e=r.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914(e){"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834(e,t,n){"use strict";const{HEX:i}=n(4914),o=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function r(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(o)||[],[n]=t;return 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t=[];for(;e.length;)if(e.match(u))e=e.replace(u,"");else if(e.match(h))e=e.replace(h,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(m);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:a,stringArrayToHexStripped:s}},3837(e){"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216(e){"use 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