@datagrok/bio 2.25.12 → 2.25.13

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Files changed (9) hide show
  1. package/dist/package-test.js +1 -1
  2. package/dist/package-test.js.map +1 -1
  3. package/dist/package.js +1 -1
  4. package/dist/package.js.map +1 -1
  5. package/package.json +1 -1
  6. package/src/utils/monomer-lib/monomer-manager/match-molecules.ts +347 -0
  7. package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +4 -82
  8. package/test-console-output-1.log +552 -525
  9. package/test-record-1.mp4 +0 -0
package/dist/package-test.js CHANGED
@@ -4,5 +4,5 @@ var bio_test;(()=>{var e={8924(e,t,n){"use strict";n.d(t,{X:()=>o});var i=n(7362
4
4
  || ${a} === "boolean" || ${o} === null`).assign(l,s._`[${o}]`)}}i.else(),p(e),i.endIf(),i.if(s._`${l} !== undefined`,()=>{i.assign(o,l),function({gen:e,parentData:t,parentDataProperty:n},i){e.if(s._`${t} !== undefined`,()=>e.assign(s._`${t}[${n}]`,i))}(e,l)})}(e,t,a):p(e)})}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,i=l.Correct){const o=i===l.Correct?s.operators.EQ:s.operators.NEQ;let r;switch(e){case"null":return s._`${t} ${o} null`;case"array":r=s._`Array.isArray(${t})`;break;case"object":r=s._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":r=a(s._`!(${t} % 1) && !isNaN(${t})`);break;case"number":r=a();break;default:return s._`typeof ${t} ${o} ${e}`}return i===l.Correct?r:(0,s.not)(r);function a(e=s.nil){return(0,s.and)(s._`typeof ${t} == "number"`,e,n?s._`isFinite(${t})`:s.nil)}}function d(e,t,n,i){if(1===e.length)return h(e[0],t,n,i);let o;const r=(0,a.toHash)(e);if(r.array&&r.object){const e=s._`typeof ${t} != "object"`;o=r.null?e:s._`!${t} || ${e}`,delete r.null,delete r.array,delete r.object}else o=s.nil;r.number&&delete r.integer;for(const e in r)o=(0,s.and)(o,h(e,t,n,i));return o}t.checkDataType=h,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?s._`{type: ${e}}`:s._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:n,schema:i}=e,o=(0,a.schemaRefOrVal)(e,i,"type");return{gen:t,keyword:"type",data:n,schema:i.type,schemaCode:o,schemaValue:o,parentSchema:i,params:{},it:e}}(e);(0,r.reportError)(t,m)}t.reportTypeError=p},7870(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const i=n(9029),o=n(4227);function r(e,t,n){const{gen:r,compositeRule:s,data:a,opts:l}=e;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(t)}`;if(s)return void(0,o.checkStrictMode)(e,`default is ignored for: ${c}`);let u=i._`${c} === 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n=u.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function T(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:p}=e,{RULES:g}=p;function f(m){(0,r.shouldUseGroup)(a,m)&&(m.type?(o.if((0,s.checkDataType)(m.type,l,d.strictNumbers)),A(e,m),1===t.length&&t[0]===m.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):A(e,m),c||o.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(a,g)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach(t=>{E(e.dataTypes,t)||S(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)}),function(e,t){const n=[];for(const i of e.dataTypes)E(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&S(e,"use 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r=t.name("valid");n.forEach((t,n)=>{if((0,i.alwaysValidSchema)(o,t))return;const s=e.subschema({keyword:"allOf",schemaProp:n},r);e.ok(r),e.mergeEvaluated(s)})}};t.default=o},6505(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=i},2661(e,t,n){"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),o=n(4227),r={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?i.str`must contain at least ${e} valid item(s)`:i.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?i._`{minContains: ${e}}`:i._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:r,data:s,it:a}=e;let 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o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new U("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new U("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new U("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other 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n=n.next,{done:!1,value:e}}):_.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var u=r,h=u.key,d=u.attributes,m=u.source,p=u.target;if(l=i(h,d,m.key,p.key,m.attributes,p.attributes,r.undirected),e&&l)return h}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function me(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new he;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function pe(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new _(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),m=i.type;!0!==(r=d.next()).done;){var p=!1;if(s=r.value,"undirected"!==m)for(a in l=s.out){c=l[a];do{if(u=c.target,p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==m)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!p&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new B('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new B("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new B('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new B("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new B("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new B("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Te={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function Ee(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new U("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new U("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new U("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new U("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new j(i,o,l,u,a);e._edges.set(o,d);var m=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,m&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,m&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Se(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new U("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new U("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new B("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new U("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new U("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var w=!1,v=!1;p||(p=Ae(e,r,{}),w=!0,r===s&&(g=p,v=!0)),g||(g=Ae(e,s,{}),v=!0),d=new j(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,w,v]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var xe=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Te,e)).multi)throw new B("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new B('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new B("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?W:"directed"===e.type?q:Y;h(s(t),"NodeDataClass",i);var o="geid_"+we()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new B("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new U("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new B('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new U('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new B('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new B('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new B("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new B("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new B("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new B("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new B("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new B("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new B("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new B("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new B("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new B("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new B("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new B("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new B("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new B("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new _(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new B("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new B("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new B("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new B("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var p=s,g=p.source,f=p.target,y=p.attributes,b=p.undirected,w=void 0===b?m:b;"key"in s?(l?w?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:w?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?w?this.mergeUndirectedEdge:this.mergeDirectedEdge:w?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach(function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)}),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new U('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new U("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new U("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)Ee(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach(function(e,t){n[t]=e.attributes});var i={},o={};this._edges.forEach(function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[u]?o[u]=0:o[u]++,a+="".concat(o[u],". 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n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(r.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){r.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}var R=n(9713),$=n(6295);const O=e=>null==e;function H(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class D{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,g=Number.MIN_VALUE;for(let 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Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)H(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)H(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,G=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class B{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new G.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,w=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let v=null==b?void 0:b.x,C=null==b?void 0:b.y;const T=this.sp.pointToScreen(this.lines.to[e]);let A=null==T?void 0:T.x,E=null==T?void 0:T.y;const S=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),v&&C&&A&&E&&Math.hypot(A-v,E-C)/S>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let T=null;if(b){t=this.getLineLength(v,C,A,E);const o=this.getPointOnDistance(v,C,A,E,i,t),r=this.getPointOnDistance(A,E,v,C,n,t);v=o.x,C=o.y,A=r.x,E=r.y,T=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,v,C,A,E,e):this.findControlPoint(b,A,E,v,C,e),this.ctx.moveTo(v,C),this.ctx.quadraticCurveTo(T.x,T.y,A,E)}else(!this.lines.skipShortLines||Math.pow(A-v,2)+Math.pow(E-C,2)>w)&&(this.ctx.moveTo(v,C),this.ctx.lineTo(A,E));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(v,C,A,E)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(v,C,A,E,i,t),n=b?T.x:v,o=b?T.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:v,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new G.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var U,W=n(3629);async function q(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,W.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(U||(U={}));const Y={[U.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[U.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var j;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(j||(j={}));const K={[j.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[j.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[j.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[j.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[j.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[j.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[j.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[j.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[j.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[j.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[j.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[j.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[j.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},z={[j.HAMMING]:e=>Math.ceil(e/30),[j.EUCLIDEAN]:e=>Math.ceil(e/30),[j.MANHATTAN]:e=>Math.ceil(e/30),[j.TANIMOTO]:e=>Math.ceil(e/30),[j.SOKAL]:e=>Math.ceil(e/30),[j.COSINE]:e=>Math.ceil(e/30),[j.ASYMMETRIC]:e=>Math.ceil(e/30),[j.LEVENSTEIN]:e=>Math.ceil(e*e/60),[j.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[j.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[j.Difference]:e=>1,[j.OneHot]:e=>Math.ceil(e/40),[j.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([j.HAMMING,j.LEVENSTEIN,j.NEEDLEMAN_WUNSCH,j.MONOMER_CHEMICAL_DISTANCE,j.OneHot]),UINT32ARRAY:new Set([j.HAMMING,j.EUCLIDEAN,j.MANHATTAN,j.MONOMER_CHEMICAL_DISTANCE,j.LEVENSTEIN,j.NEEDLEMAN_WUNSCH,j.TANIMOTO,j.COSINE,j.VECTOR_COSINE,j.SOKAL,j.ASYMMETRIC,j.OneHot,j.Difference]),INT32ARRAY:new Set([j.EUCLIDEAN,j.MANHATTAN,j.OneHot,j.Difference,j.VECTOR_COSINE]),FLOAT32ARRAY:new Set([j.EUCLIDEAN,j.MANHATTAN,j.Difference,j.VECTOR_COSINE]),NUMBER:new Set([j.EUCLIDEAN,j.MANHATTAN,j.Difference]),BITARRAY:new Set([j.TANIMOTO,j.COSINE,j.SOKAL,j.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return E(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!S&&(S=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==S))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=S.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield S.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield S.requestDevice(),M}}return M})}();if(!s)return null;const a=Object.values(j);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(U).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map((e,t)=>function(e,t=j.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=z[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===j.NEEDLEMAN_WUNSCH||t===j.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===j.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",w=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:w,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),w=Math.ceil(6e3/b),v=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*v,T=u*(u-1)/2,A=Math.ceil(T/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${A} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${w}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${Q(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),P=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),_=new Uint32Array(f),N=new Uint32Array(f),R=Math.floor(T/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?T-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,_[e]=i,N[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const H=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),D=h.reduce((e,t)=>e+t.suppInfoSize,0),k=1e6,F=H*Uint32Array.BYTES_PER_ELEMENT;let G=F;const B=15&F;0!==B&&(G+=16-B);const V=s.createBuffer({label:"compute info buffer",size:G,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let q=0;new Uint32Array(W,q,f).set(I),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(L),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(_),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(N),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g.length).set(g),q+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,q,c).set(o),q+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,q,n).set(e.flatSourceArray),q+=n*t.BYTES_PER_ELEMENT}V.unmap();const Y=D*Uint32Array.BYTES_PER_ELEMENT;let K=Y;const X=15&Y;0!==X&&(K+=16-X),K=Math.max(K,16);const J=s.createBuffer({label:"supp info buffer",size:K,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=J.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),J.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:P.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:J}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(P),t.setBindGroup(0,se),t.dispatchWorkgroups(v,v),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,k);o+=k*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,k);o+=k*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,k);o+=k*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),J.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function Q(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${K[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${Y[i](e.length)}\n }\n \n `}var J=n(1991),ee=n.n(J);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,i,a,l,c,u,h,d,m,p,g,f,y,b,w,v){te++;const C=c/100;let T,A=!1;const E=g.inputs,S=await g.apply({[E[0].name]:t,[E[1].name]:u,...d.preprocessingFuncArgs??{}});let M=[];if(h===L){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([S.entries],c,[1],"MANHATTAN",[u],[S.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),M=[t.embedX,t.embedY]}else M=await q([S.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[S.options??{}]});if(M.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<M.length;++t)e.columns.addNewFloat(i[t]).init(e=>M[t][e]);let x=null;if(d.useWebGPU)try{x=await X([S.entries],C,[u],U.MANHATTAN,[1],[S.options??{}])}catch(e){console.error(e)}x||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),x=await(new k).calc(S.entries,u,C,S.options));const P=await async function(e,t){const 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t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(P.saliVals),$=.8/(N.max-N.min),O=o.shell.tv?.dataFrame===e?o.shell.tv:o.shell.getTableView(e.name),H=O.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:a}),D=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(e,P,t,l,m,p,N,$);D.lines.skipMultiLineCalculation=!0,D.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const G=new B(H,i[0],i[1],D.lines,F.none),V=b?b(D.linesDf,se).sort([oe],[!1]):D.linesDf.plot.grid().sort([oe],[!1]);V.col(re)&&(V.col(re).visible=!1),e.temp[".cliffsDfGrid"]=V;const W=r.button(`${D.linesDf.rowCount} cliffs`,()=>{const e=ee()(O.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);v&&!e&&O.addViewer(V),O.dockManager.dock(V,"down",null,"Activity 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n=H.dataFrame.getSortedOrder(O.grid.sortByColumns,O.grid.sortTypes);O.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))},1e3)}}),D.linesDf.onSelectionChanged.subscribe(t=>{setTimeout(()=>(()=>{const t=s.BitSet.create(e.rowCount);for(let e=0;e<D.linesDf.rowCount;e++){const n=D.linesDf.selection.get(e);n&&(t.set(D.lines.from[e],!0),t.set(D.lines.to[e],!0)),D.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),G.linesToRender=D.lines})(),100)}),e.onSelectionChanged.subscribe(t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<D.lines.colors.length;e++)D.lines.colors[e]="0,128,0";G.linesToRender=D.lines})(V.dataFrame))}),G.lineClicked.subscribe(t=>{if(A=!0,G.currentLineId=t.id,-1!==t.id){const n=D.linesDf.selection.clone();setTimeout(()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),D.linesDf.selection.copyFrom(n)):(D.linesDf.currentRowIdx!==t.id&&(D.linesDf.currentRowIdx=t.id,e.currentRowIdx=D.lines.from[t.id]),D.linesDf.selection.copyFrom(n));const i=D.linesDf.getSortedOrder(V.sortByColumns,V.sortTypes);V.scrollToCell(se[0],i.indexOf(t.id))},500)}}),G.lineHover.pipe((0,R.debounceTime)(500)).subscribe(n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&r.tooltip.show(f({lineId:n.id,points:[D.lines.from[n.id],D.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)}),H.addProperty("similarityLimit","double",C),T=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}(),H}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151);function me(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getCanonical(o);(n(o)||i(o)).set(e,r,!1)}}return a}var pe,ge=n(439),fe=n(4971);async function ye(e){const t=(await(0,fe.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var be=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class ve extends N{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[L]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ce,Te,Ae;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Se(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function 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0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function S(){e.columns.add(s.Column.float(A[0],e.rowCount)),e.columns.add(s.Column.float(A[1],e.rowCount));let n=null;d&&(T=v.scatterPlot({...w,x:A[0],y:A[1],title:g.scatterPlotName??Se(t,i)}),r.setUpdateIndicator(T.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&T?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===T?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await q(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:E))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await S();if(m&&M){const x=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const P=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>P[e].toString()),T&&(T.props.colorColumnName=I)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{x.close()}}if(M){const _=e.columns.byName(A[0]),N=e.columns.byName(A[1]);if(_.init(e=>M[0][e]),N.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:_,[$]:N,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(T)return r.setUpdateIndicator(T.root,!1),T.helpUrl="/help/compute/sequence-space",T}}catch(H){o.shell.error("Dimensionality reduction failed"),console.error(H),C.close(),T&&r.setUpdateIndicator(T.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ce||(Ce={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Te||(Te={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Ae||(Ae={})),Object.prototype.toString;var xe=n(6873),Pe=n(4356),Ie=n(6717),Le=n(4025),_e=n(4870),Ne=n(3856),Re=n(6882),$e=n(7278),Oe=n(5553),He=n(6642),De=n(3599),ke=n(673),Fe=n(8312);class Ge extends He.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,wo.logger),(0,fe.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,Fe.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Be=n(4139);const Ve=ue.zS;function Ue(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class We extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=wo.seqHelper}getRendererBack(e){const[t,n,i]=(0,He.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Oe.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,He.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(wo.properties?wo.properties.maxMonomerLength:4)??50;if(Ne.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Ne.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new Re.Jy(a,l,wo.logger,d,()=>{const{font:e,fontWidth:t}=Re.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:Ve}}),l.temp[".mm.cellRenderer.settingsChanged"],ke.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class qe extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator],h=this.tableCol.meta.units;i=(0,Re.U0)(l,e,t,i,a);const[d,m]=c.split("#"),p=this.tableCol.temp[Le.j.notationProvider]?.separatorSplitter??(0,$e.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),w=this.tableCol.getTag(ue.gp.alphabet);je(e,t,n,i,o,y,b,w===ue.YI.RNA||w===ue.YI.DNA?De.o.NUCLEOTIDE:De.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new qe(t,n)),o}}class Ye extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Be.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){qe.getOrCreate(r).render(e,t,n,i,o,r,s)}}function je(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ge.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(Ue(r).join("")),d=e.measureText(Ue(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Re.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Re.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Ne.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Ne.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ke(n,c,d,r,g,h,o))}else p=(0,Ne.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ke(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ue([e]).join("")).width,u=l.measureText(Ue([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Ne.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Ne.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var ze,Ze=n(5749),Xe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ze||(ze={}));const Qe=new class{constructor(){this.regionTypes=[ze.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Xe.fH.Entropy,this.filterSource=Xe.Fo.filterSource}};var Je=n(7602),et=n(250);const tt=ze;var nt,it;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(nt||(nt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(it||(it={}));const ot=Qe;class rt extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(it.skipEmptyPositions,ot.skipEmptyPositions,{category:nt.DATA}),this.regionTypes=this.stringList(it.regionTypes,ot.regionTypes,{category:nt.DATA,choices:Object.values(tt).filter(e=>e!=tt.Unknown)}),this.chains=this.stringList(it.chains,ot.chains,{category:nt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(it.fitWidth,ot.fitWidth,{category:nt.LAYOUT}),this.positionWidth=this.float(it.positionWidth,ot.positionWidth,{category:nt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(it.positionHeight,ot.positionHeight,{category:nt.LAYOUT,choices:Object.keys(Xe.fH)}),this.filterSource=this.string(it.filterSource,ot.filterSource,{category:nt.BEHAVIOR,choices:Object.values(Xe.lT)}),this.viewSyncer=new Je.g(wo.logger)}static viewerCounter=-1;viewerId=++rt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case it.regionTypes:case it.chains:this.setData(this.regions)}switch(e.name){case it.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case it.fitWidth:case it.positionWidth:this.calcSize();break;case it.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionHeight]:this.positionHeight});this.calcSize();break;case it.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;wo.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){wo.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){wo.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Xe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),wo.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){wo.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[et.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(it.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[et.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Ze.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class st{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class at{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new at(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ct(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=wo.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,fe.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await ye(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await ye(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ut=n(4954);function ht(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function dt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=wo.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=pt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function pt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=wo.monomerLib;return je(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function gt(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function ft(e,t){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class yt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class bt extends yt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const wt={gapPenalty:1,matchScore:1,gapSymbol:ge.b9[ge.Hi.FASTA],localAlignment:!1};class vt extends bt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,_e.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,_e.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ct(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new k).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...wt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new $e.Mu(d,i.gapSymbol),seq2Splitted:new $e.Mu(m,i.gapSymbol)}}(c,u),d=pt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class Ct extends bt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,_e.Kd)(i,t.name,450,30),(0,_e.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ct(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new D(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Tt,At=n(5433),Et=n(3890),St=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Tt||(Tt={}));class Mt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class xt extends Mt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends xt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(Tt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(Tt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(Tt.TYPE)&&-1!==e.indexOf(Tt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Tt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Tt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Tt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Tt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class It extends xt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Lt{constructor(){}static getInstance(e){if(Lt.isMolfileV2K(e))return new Pt(e);if(Lt.isMolfileV3K(e))return new It(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return It.isValidMolfile(e)}}var _t=n(6197),Nt=n(9124),Rt=n(3527);class $t{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++$t.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ot extends $t{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Ht extends $t{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Dt extends $t{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class kt extends $t{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Ft extends $t{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Gt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Ft(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Gt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Bt={[De.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[De.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[De.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[De.o.CHEM]:{R:"#eeeeee"},[De.o.BLOB]:{B:"#999999",G:"#e2e2e2"}};class Vt{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Ut={A:new G.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new G.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new G.A(new 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new G.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Wt[t])return null;const o=Wt[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var Yt=n(857),jt={};jt.styleTagTransform=C(),jt.setAttributes=y(),jt.insert=g().bind(null,"head"),jt.domAPI=m(),jt.insertStyleElement=w(),h()(Yt.A,jt),Yt.A&&Yt.A.locals&&Yt.A.locals;const Kt=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];var zt;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(zt||(zt={}));const Zt={[zt.MONOMER]:s.COLUMN_TYPE.STRING,[zt.SYMBOL]:s.COLUMN_TYPE.STRING,[zt.NAME]:s.COLUMN_TYPE.STRING,[zt.R_GROUPS]:s.COLUMN_TYPE.STRING,[zt.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[zt.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[zt.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[zt.AUTHOR]:s.COLUMN_TYPE.STRING,[zt.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[zt.ID]:s.COLUMN_TYPE.INT,[zt.META]:s.COLUMN_TYPE.STRING,[zt.SOURCE]:s.COLUMN_TYPE.STRING};async function Xt(e){const t=await Qt(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>un(t.rows.get(n))))}async function Qt(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Zt))if(t.columns.addNew(e,n),e===zt.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(zt.SYMBOL).semType="Monomer",t.col(zt.SYMBOL).setTag(Ne.Mn.applyToBackground,"true"),t.col(zt.SYMBOL).setTag(ge.qE.polymerTypeColumnName,zt.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=an(e[n].rgroups,e[n].smiles,e[n].molfile);o=en(o),e[n].rgroups=rn(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?nn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(zt.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(zt.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class Jt{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(zt.NAME).width=100,this.tv.grid.col(zt.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new sn(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(zt.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await On.getInstance();await e.awaitLoaded(),this.instance=new Jt(e)}return this.instance}static async getNewInstance(){const e=await On.getInstance();return await e.awaitLoaded(),new Jt(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>un(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>un(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await un(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===Jt.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:Jt.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>un(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await un(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,fe.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=Jt.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await un(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,fe.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await Qt(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,fe.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>un(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function en(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const tn=["alternateId","capGroupName","capGroupSMILES","label"];function nn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function on(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function rn(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(tn,e),n=nn(t,"capGroupSMILES"),i=nn(t,"alternateId"),o=nn(t,"capGroupName"),r=nn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class sn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new hn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=an([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await qt(cn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Vt(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Vt(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=rn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&qt(cn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=an(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,fe.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(zt.POLYMER_TYPE)?.toList()??[],s=n?.col(zt.SYMBOL)?.toList()??[],a=n?.col(zt.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,fe.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await un(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await un(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=an([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=ln(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function an(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=en(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function ln(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function cn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=nn(e,"capGroupName"),r=nn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function un(e){let t;try{t=JSON.parse(e.get(zt.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(zt.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=ln(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(zt.NATURAL_ANALOG);const a=e.get(zt.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(zt.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=nn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?on(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?on(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?on(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&on(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=nn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&on(e,"capGroupSMILES",`${nn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await qt(cn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(zt.SYMBOL),name:e.get(zt.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(zt.MONOMER_TYPE),naturalAnalog:r,id:e.get(zt.ID),rgroups:l,meta:t,author:e.get(zt.AUTHOR),createDate:e.get(zt.CREATE_DATE)}}class hn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}const dn=/.*\|\$.*R.*\$\|/,mn=/\[R(\d+)\]/,pn=/\[R(\d+)\]/g,gn=/\[\*:(\d+)\]/g;function fn(e,t){const n=Array.from(e.matchAll(pn)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=ln(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){wo.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const yn=/[\w()]+/,bn=RegExp(String.raw`\(${yn}(,${yn})+\)`),wn=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},vn=new Rt.Mi([255,255,255]),Cn=new Rt.Mi([0,0,0]),Tn=.7*(0,W.wQ)(vn);class An{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==ge._S||t===ge.b9[ge.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(dn.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return fn(a,t)}let n=e;const i=Array.from(e.matchAll(gn));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(mn.test(n))return fn(n,t)}catch(t){wo.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Ot((0,$e.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,Nt.fA)(e,t),o=(0,_t.Y)(n);let r=this.getMonomer(o,i);if(r&&n==De.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==De.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ge._S||"*"==i?s=r.wem=new Ht(n):n===De.o.NUCLEOTIDE&&"N"===i||n===De.o.AA&&"X"===i||(De.o.CHEM,0)||bn.test(i)?s=r.wem=new Dt(n,i):r.lib||(s=r.wem=new kt(n,i,this.isEmpty)),s||(s=r.wem=Gt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,_t.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?wn(s.molfile):s.smiles?r.divV([wn(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=ge._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Rt.Mi([...o.map(e=>e+1)]),a=(0,W.KE)(r,vn)/((0,W.wQ)(r)*(0,W.wQ)(vn)),l=i(n.backgroundcolor),c=new Rt.Mi([...l.map(e=>e+.01)]);let u;u=(0,W.KE)(c,vn)/((0,W.wQ)(c)*(0,W.wQ)(vn))<a?l:o;let h=new Rt.Mi(u);const d=(0,W.wQ)(h);return d>Tn&&(h=(0,W.dC)(Cn,h,Tn/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,_t.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){wo.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Bt[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var En=n(5488),Sn={};Sn.styleTagTransform=C(),Sn.setAttributes=y(),Sn.insert=g().bind(null,"head"),Sn.domAPI=m(),Sn.insertStyleElement=w(),h()(En.A,Sn),En.A&&En.A.locals&&En.A.locals;class Mn extends An{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,_t.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Lt.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Pe.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new xn(e,`override: ${++Mn.overrideCounter}, ${t}`,this)}}class xn extends An{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Pn=n(8604),In=n(7433),Ln=n.n(In),_n=n(1913),Nn=n.n(_n);class Rn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Ln())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Nn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class $n{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=fe.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText($n.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new Rn(i);$n._instance=new $n(r,e,t),$n._instance.refreshLists()}return $n._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new fe.lH(n,i,o,r,s)});t.push(new fe.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}class On{logger;_monomerLib=new Mn({},"MAIN");_monomerSets=new fe.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await(0,Ze.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await $n.getInstance(this,wo.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++On.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return On.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Pe.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new Mn(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Pe.E)(Pn.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new Mn(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===fe.ic);if(!t)throw new Error(`Provider '${fe.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new Mn(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,fe.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new On(wo.logger))()),e}}var Hn=n(1757),Dn=n.n(Hn);class kn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new kn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Gn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Gn._instance||(Gn._instance=new Gn,await Gn._instance.refresh(),(await On.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Gn._instance.refresh())),Gn._instance.refresh(),Gn._instance}async refresh(){this.settings=await(0,Pe.u)();const e=await On.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Bn=n(3017),Vn={};async function Un(){await Kn.showDialog()}async function Wn(e=!0){return await zn.showView(e)}Vn.styleTagTransform=C(),Vn.setAttributes=y(),Vn.insert=g().bind(null,"head"),Vn.domAPI=m(),Vn.insertStyleElement=w(),h()(Bn.A,Vn),Bn.A&&Bn.A.locals&&Bn.A.locals;class qn{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==qn.instancePromise&&(qn.instancePromise=(async()=>{const e=new qn,t=await(0,fe.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),qn.instancePromise}static async reloadWidget(){const e=await qn.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,fe.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await Yn.createControlsForm();return Dn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&Dn()(e)&&Dn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class Yn{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){wo.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Pe.u)(),t=await(0,fe.pj)();return new Yn(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Dn()(t).addClass("monomer-lib-controls-form"),t}async updateControlsForm(){const e=await this._createControlsForm();Dn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;wo.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{jn(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=r.icons.edit(async()=>{o.shell.v=await(await Jt.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),wo.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await jn(!1,e);const n=await(0,fe.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function jn(e,t){const n=await(0,Pe.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Pe.E)(n);const i=await(0,fe.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class Kn{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){Kn._instance||(Kn._instance=new Kn,Kn._instance.closeDialogSubject$.subscribe(()=>{Kn._instance.dialog=void 0})),Kn._instance.dialog||(Kn._instance.dialog=await Kn._instance.getDialog()),Kn._instance.dialog.show()}async getDialog(){const e=(await qn.getInstance()).widget,t=await(0,fe.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Dn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class zn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await qn.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=zn.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=zn._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return zn._instance||(zn._instance=new zn),zn._instance._duplicateManager||(zn._instance._duplicateManager=await Gn.getInstance()),zn._instance.libManager||(zn._instance.libManager=await On.getInstance()),e&&zn._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===zn._instance._view.id)?(o.shell.v=zn._instance._view,await zn._instance._duplicateManager.refresh(),zn._instance._view):(zn.closeExistingViews(),zn._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===zn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await On.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Pe.u)();i.exclude=l,await(0,Pe.E)(i),await this.libManager.loadMonomerLib(!0),await qn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Zn,Xn=n(8070),Qn=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class Jn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>Qn(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>Qn(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>Qn(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>Qn(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,Jn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Qn(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Xn.cb)(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return Qn(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Qn(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Qn(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return Qn(this,void 0,void 0,function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Jn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Qn(this,void 0,void 0,function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}Jn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Zn||(Zn={}));var ei=n(966),ti=n(608),ni=n(1619);class ii{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${wo.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case et.n5.fixWidth:case et.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class oi{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var ri=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const si="-";class ai extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Ne.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ge._S||(a=si);const l=a.split(ge.ot).map(e=>e&&e!==ge._S?e.trim():si),c=l.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),u=c.map(t=>e.measureText(t).width),h=u.reduce((e,t)=>e+t,0);let d=t+(i-h)/2;const m=this.tableCol.getTag(ge.gp.alphabet),p=m===ue.YI.RNA||m===ue.YI.DNA?ri.o.NUCLEOTIDE:ri.o.AA;for(let a=0;a<c.length;a++){const h=l[a],m=this.getHelmType(r,p);let g=Re.S$,f="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,h);g=e?.textcolor??g,f=e?.backgroundcolor??f}else g=this.monomerLib.getMonomerTextColor(m,h);s&&1==l.length&&(e.fillStyle=f,e.fillRect(t,n,i,o)),e.fillStyle=g,e.fillText(c[a],d,n+o/2,i),d+=u[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,He.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(ge.gp.alphabet),a=e.cell.value,l=e.grid.canvas.getBoundingClientRect(),c=e.bounds.right+l.left-4,u=e.bounds.bottom+l.top-4;if(!a||a==ge._S||a==si)return r.tooltip.show(r.divText("gap"),c,u),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),c,u),!0;const h=s===ue.YI.RNA||s===ue.YI.DNA?ri.o.NUCLEOTIDE:ri.o.AA,d=a.split(ge.ot).map(t=>{if(!t||t===ge._S||t===si)return r.divText("gap");const n=this.getHelmType(e,h);return this.monomerLib.getTooltip(n,t)}),m=r.divH(d,{style:{alignItems:"top"}}),p=Array.from(m.querySelectorAll("canvas"));if(p.length>2){const e=Math.floor(550/p.length);p.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(m,c,u),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,He.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(ge.qE.polymerTypeColumnName)){const t=o.getTag(ge.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,$e.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ai(t,n)),o}}class li extends s.GridCellRenderer{get name(){return Be.uF.MONOMER}get cellType(){return Be.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){ai.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){ai.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class ci{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ui extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class hi extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ci(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,be.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var di=n(6307),mi=n(5999),pi={};pi.styleTagTransform=C(),pi.setAttributes=y(),pi.insert=g().bind(null,"head"),pi.domAPI=m(),pi.insertStyleElement=w(),h()(mi.A,pi),mi.A&&mi.A.locals&&mi.A.locals;class gi extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=wo.properties.tooltipWebLogo,n=this.seqCol.getTag(Xe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function fi(e,t,n,i){const o=wo.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const yi={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class bi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??yi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${wo.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class wi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ue.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{wo.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{wo.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var vi=n(8754);async function Ci(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=me(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ge._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=me(e,n).columns.toList());const i=(await(0,fe.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):ge._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==ge._S&&t!==p?l[e]+=y[t]:c===ge._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null===u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Ti=n(294),Ai=n(330);const Ei=OCL;var Si=n(2582);class Mi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var xi=n(6956);class Pi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===xi.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=Lt.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const w=new Map;w.set(p+1,e+1);let v=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),w.set(e+1,v),v++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=w.get(t),o=w.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Ii{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Li extends Ii{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class _i{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ni extends _i{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Ri extends Mi{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new Li(n),this.bonds=new Ni(n),this.rGroups=new Pi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class $i extends Ii{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Oi extends _i{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Hi extends Mi{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new $i(n),this.bonds=new Oi(n),this.rGroups=new Pi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Di{static getInstance(e,t){if(Lt.isMolfileV2K(e))return new Ri(e,t);if(Lt.isMolfileV3K(e))return new Hi(e,t);throw new Error("Unsupported molfile version")}}class ki{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Lt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Di.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(ki.molfileV2KToV3KCache.has(e))return ki.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return ki.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Fi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Si.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ge.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new ki(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Ti.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?De.o.NUCLEOTIDE:De.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Gi{constructor(e){this.molfileHandler=Lt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Bi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Ei.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,be.AP)(e);return wo.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,Ai.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Ti.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,be.AP)(e);wo.logger.error(t,void 0,n),o=Ti.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Gi(o),s=new Fi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Ti.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Ti.vF(a.molfile,l)}}var Vi=n(2738);class Ui{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[Le.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[Le.j.notationProvider]??null);const i=this.isFasta()?ge.b9[ue.Hi.FASTA]:this.isSeparator()?ge.b9[ue.Hi.SEPARATOR]:this.isHelm()?ge.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ge.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[Le.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,$e.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new Vi.aD(e.name,e.alphabet,.9));t=(0,$e.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?De.o.NUCLEOTIDE:De.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ge.b9[ue.Hi.FASTA]?ge._S:i??ge._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ge._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ge.b9[ue.Hi.FASTA]?ge._S:o??ge._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new Le.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!Ui.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:$e.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,fe.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ge.b9[ue.Hi.FASTA]:ge.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===ge.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ge.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new $e.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Wi(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return qi(n,t,e)};break}case ue.Hi.BILN:i=function(e){return Yi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[Le.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Le.j.seqHandler]=new Ui(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===ge._S?r=ge.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Wi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return qi(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:Yi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new $e.Mu(n.filter(e=>!!e),ge.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Wi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===ge._S?r=ge.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function qi(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ge._S?r=ge.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ge._S?s=ge.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function Yi(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class ji{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Ui.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Nt.b2)();return new Bi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Ti.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Ti.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Ti.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Ti.vF(e,o.monomers)}catch(e){const[t,n]=(0,be.AP)(e);return wo.logger.error(t,void 0,n),Ti.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,Ai.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,Ui.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),Ui.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,Ui.setTags(e)}}async function Ki(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await Co.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[Le.j.notationProvider]&&(i.temp[Le.j.notationProvider]=e.cell.column.temp[Le.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Co.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){wo.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const zi="#333333",Zi="rgba(60, 177, 115, 0.1)",Xi="rgba(240, 240, 240, 0.5)",Qi="rgba(100, 100, 100, 0.3)";class Ji{constructor(e=no.DEFAULT_TRACK_HEIGHT,t=no.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class eo extends Ji{constructor(e=new Map,t=no.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,no.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=De.o.NUCLEOTIDE;break;default:t=De.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,di.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=Zi,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=Xi,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class to extends Ji{constructor(e,t=no.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,no.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=Zi,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=Xi,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=zi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const no={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},io={BASE:no.DOTTED_CELL_HEIGHT+no.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+no.TITLE_HEIGHT+no.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+no.DEFAULT_TRACK_HEIGHT+no.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+no.DEFAULT_TRACK_HEIGHT+no.TRACK_GAP}};class oo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||io.BASE,sliderHeight:e.sliderHeight||no.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(no.DEFAULT_TRACK_HEIGHT)}),!(e<io.WITH_TITLE()||e<io.WITH_WEBLOGO()))if(e<io.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-io.WITH_WEBLOGO();t.setHeight(no.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>io.WITH_BOTH()){const n=e-io.WITH_BOTH();t.setHeight(no.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<io.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<io.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=io.WITH_TITLE()?(no.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=io.WITH_TITLE()?no.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=io.WITH_WEBLOGO();else{if("conservation"!==e)return;t=io.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?io.WITH_BOTH():io.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=io.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,no.TITLE_HEIGHT),this.ctx.fillStyle=zi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+no.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof eo&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=io.WITH_TITLE()?no.TITLE_HEIGHT:0,l=this.config.headerHeight-no.SLIDER_HEIGHT-no.DOTTED_CELL_HEIGHT,c=l-no.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[],m=this.getTrack("weblogo");m&&m.isVisible()&&d.push({id:"weblogo",track:m});const p=this.getTrack("conservation");p&&p.isVisible()&&d.push({id:"conservation",track:p});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){u=e,h=n-i;break}g=i-no.TRACK_GAP}let f=null;if(u){const e=this.tracks.get(u);e&&(f=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=f,u)){const e=this.tracks.get(u);e instanceof eo&&(e.setHovered(s,f),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=f,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,f);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=io.WITH_TITLE();l&&no.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-no.SLIDER_HEIGHT,u=c-no.DOTTED_CELL_HEIGHT,h=u-no.TRACK_GAP,d=[],m=[],p=this.getTrack("weblogo");p&&p.isVisible()&&m.push({id:"weblogo",track:p});const g=this.getTrack("conservation");g&&g.isVisible()&&m.push({id:"conservation",track:g});let f=h;for(const{track:e}of m){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-no.TRACK_GAP}if(this.drawDottedCells(0,u,n,no.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:no.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+no.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=zi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,no.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,no.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,no.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-no.SLIDER_HEIGHT;return t>n&&t<n+no.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-no.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+no.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=io.WITH_TITLE()?no.TITLE_HEIGHT:0,a=this.config.headerHeight-no.SLIDER_HEIGHT-no.DOTTED_CELL_HEIGHT,l=a-no.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-no.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=io.WITH_TITLE()&&t&&(ro(e.left??0,n,i)||ro(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-no.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:io.BASE,WITH_TITLE:io.WITH_TITLE(),WITH_WEBLOGO:io.WITH_WEBLOGO(),WITH_BOTH:io.WITH_BOTH()}}}function ro(e,t,n){return e>=t&&e<=n}class so{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){so.conservationCache=new s.LruCache(100),so.webLogoCache=new s.LruCache(100),so.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return so.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return so.conservationCache.getOrCreate(i,()=>{const o=so.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return so.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/so.CHUNK_SIZE)*so.CHUNK_SIZE,s=Math.ceil(n/so.CHUNK_SIZE)*so.CHUNK_SIZE;for(let t=r;t<s;t+=so.CHUNK_SIZE){const n=Math.min(t+so.CHUNK_SIZE,i),r=so.getChunkCacheKey(e.column,t,n),s=so.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/so.CHUNK_SIZE)*so.CHUNK_SIZE,s=Math.ceil(n/so.CHUNK_SIZE)*so.CHUNK_SIZE;for(let t=r;t<s;t+=so.CHUNK_SIZE){const n=Math.min(t+so.CHUNK_SIZE,i),r=so.getChunkCacheKey(e.column,t,n),s=so.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class ao extends eo{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=so.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=so.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class lo extends to{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=so.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=so.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const co="__msa-scroller-initialized",uo="__msa-scroller-subscription";class ho extends Vi.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return ge.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=$e.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ge.Hi.HELM})(n)}createCellRendererBack(e,t){const n=wo.properties.maxMonomerLength||4,i=new mo(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class mo extends Re.Jy{constructor(e,t,n,i){super(e,t,wo.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Re.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:$e.zS}})}}var po,go;!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(po||(po={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(){return await o.functions.call("Bio:ManageMonomerLibrariesView",{})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(go||(go={}));var fo=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},yo=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},bo=function(e,t){return function(n,i){t(n,i,e)}};const wo=new hi;let vo=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class Co{static async getMonomerLibHelper(){return await On.getInstance()}static async initBio(){null==vo&&(vo=async function(){const e="Bio: _package.initBio()";wo.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Ie.j)(),i=await wo.getProperties(),r=new ui(i);wo.properties=r;const a=await On.getInstance(),l=await(0,Pe.u)();l.explicit&&(l.explicit=[],await(0,Pe.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();wo.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new ji(a,n);wo.completeInit(m,u,h,n),wo.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[uo]||(t.temp[uo]=[]);let i=t.temp[uo];i.forEach(e=>e.unsubscribe()),t.temp[uo]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[co];i.temp[co]=!0;let l=null;try{l=wo.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>Re.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],w=l.splitter(b),v=w?w.length:30,C={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let T;T=e.length>1e5||v<50?C.WITH_TITLE:e.length>5e4?C.WITH_WEBLOGO:C.WITH_BOTH;let A=null,E=null;const S=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{so.clearAllCaches(),A&&(A.resetViewportTracking(),A.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(S);const M=o=>{const c=[],h=new lo(l,v,45,"default","Conservation");E=h,c.push({id:"conservation",track:h,priority:1});const g=new ao(l,v,45,"WebLogo");A=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:2});const f=new oo({canvas:t.overlay,headerHeight:T,totalPositions:v+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<C.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);f.setupTooltipHandling(),c.forEach(({id:e,track:t})=>{f.addTrack(e,t)}),f.setSelectionData(n,e,l),v>50&&!a&&(t.props.colHeaderHeight=T,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>f.detach()});const y=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==y?.dart)return;const i=t.bounds;if(!i)return;f.headerHeight=i.height;const o=p();f.positionWidth=o+8;const r=d();f.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,fe.pj)().then(e=>{const t=e.getMonomerLib();M(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await vo}static sequenceTooltip(e){const t=new gi(e,wo.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Xt(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await Xt(l);c.forEach((e,t)=>{e.lib=l[t].lib});const u=c.filter(e=>!!e.smiles).reduce((e,t)=>(e[t.smiles]={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source},e),{}),h=c.map((e,t)=>({symbol:e.symbol,smiles:cn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:l[t]?.lib?.source})).filter(e=>!!e?.smiles&&!e.smiles.includes("[*:")),d=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",h.map(e=>e.smiles));d.semType=s.SEMTYPE.MOLECULE;const m=await a.apply({molecule:d,targetNotation:s.chem.Notation.Smiles});if(!m||m.length!==d.length)throw new Error("Error canonicalizing monomer smiles");m.toList().forEach((e,t)=>h[t].smiles=e);const p=h.reduce((e,t)=>(e[t.smiles]=t,e),{}),g=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return an([],t?void 0:e,t?e:void 0)}catch(t){return e}}),f=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesOriginalCorrected",g);f.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([f]);const y=await a.apply({molecule:f,targetNotation:s.chem.Notation.Smiles});if(!y||y.length!==f.length)throw new Error("Error canonicalizing molecules");const b=y.toList(),w=e.clone(),v=w.columns.addNewString(w.columns.getUnusedName("Matched monomer smiles"));v.semType=s.SEMTYPE.MOLECULE;const C=w.columns.addNewString(w.columns.getUnusedName("Matched monomer symbol"));C.semType="Monomer";const T=w.columns.addNewString(w.columns.getUnusedName("Matched monomer source"));w.columns.setOrder([t,C.name,v.name,T.name]);for(let e=0;e<b.length;e++){const t=b[e];if(!t)continue;let n=p[t]??u[t];if(!n){const e=cn(t,Kt);if(e!==t){const t=o.chem.convert(e,s.chem.Notation.Unknown,s.chem.Notation.Smiles);n=p[t]??u[t]}}if(n){const t=n.symbol,i=(r[t]?.length??0)>0?r[t].map(e=>e?.lib?.source).filter(e=>!!e).join(", "):n.source??"",o=n.original??n.smiles;v.set(e,o,!1),C.set(e,t,!1),T.set(e,i,!1)}}return w}(e,t.name,wo.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return wo.monomerLib}static getSeqHandler(e){return wo.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:wo.name,name:t});if(1!==n.length)throw new Error(`Package '${wo.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new wi(i,wo.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Dn()(e).addClass("d4-link-action"),e.onclick=async()=>await Un(),new s.Widget(e)}()}static GetRegionEditor(e){try{new wi(e,wo.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),wo.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new oi;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new N({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new ve({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new We}static fastaSequenceCellRenderer(){return new We}static separatorSequenceCellRenderer(){return new We}static bilnSequenceCellRenderer(){return new We}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[Le.j.notationProvider]=new ho(n,wo.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=wo.properties?wo.properties.maxMonomerLength:4;if(Ne.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Ne.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=r.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=wo.properties?wo.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const a=r.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),u=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),h=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==ue.Hi.HELM&&(d=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const m=[a,i,l,u,c,h];d&&m.push(d);const p=r.inputs(m);return new s.Widget(p)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?De.o.NUCLEOTIDE:De.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===De.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,$e.MD)(n)}});const m=(0,di.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,wo.monomerLib,wo.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ye}static sequenceAlignment(e,t,n,i,o){const r=new lt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new et.oP}static vdRegionsViewer(){return new rt}static getRegion(e,t,n,i){return fi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=fi(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ei.V)(t,"Activity Cliffs"))return;const p=Ee(e),g={units:t.meta.units,aligned:t.getTag(ue.gp.aligned),separator:t.getTag(ue.gp.separator),alphabet:t.getTag(ue.gp.alphabet)},f=u,y=t,b=async()=>await le(e,y,p,"Activity cliffs",n,i,f,c,{...d??{}},s.SEMTYPE.MACROMOLECULE,g,h,ht,dt,ft,void 0,m),w=c===l.c.UMAP?2e5:2e4,v=c===l.c.UMAP?5e3:2e3;if(e.rowCount>w)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${w}`);const C=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),T=await new Promise((t,n)=>{e.rowCount>v&&!d?.[a.vb]?r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,be.AP)(e);throw wo.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return T?.props?.xColumnName&&T?.props?.yColumnName&&e.col(T.props.xColumnName)&&e.col(T.props.yColumnName)&&(e.col(T.props.xColumnName).set(0,e.col(T.props.xColumnName).get(0)),e.col(T.props.yColumnName).set(0,e.col(T.props.yColumnName).get(0))),T}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ct(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ut.BQ)(e,wo.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=G.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,l,c,u,h){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);const d=o.shell.tv.dataFrame==e?o.shell.tv:void 0;return(0,ei.V)(t,"Sequence Space")?(l||(l=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await Me(e,[t],n,[i],[1],[l],"MANHATTAN",r,u??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[a.vb],tableView:d})):void 0}static async moleculesToHelmTopMenu(e,t){const n=wo.monomerLib,i=JSON.stringify(n.toJSON());await po.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=ue.Hi.HELM,o.semType=s.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await Co.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await vo;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??wo.monomerLib,r=wo.seqHelper,s=wo.rdKitModule;await(0,vi.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Ki(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){wo.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await Ki(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await Ki(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=Ei.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,ni.D)({},wo.seqHelper).catch(e=>{const[t,n]=(0,be.AP)(e);if(e instanceof ti.Ap)return o.shell.warning(e.element),void wo.logger.warning(t);o.shell.error(t),wo.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,ni.D)({col:e,clustersCol:t,...n},wo.seqHelper)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(wo.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,ei.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>wo.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,_e.me)()[0];(0,At.C)(e,wo.seqHelper)}static convertColumnAction(e){(0,At.C)(e,wo.seqHelper)}static monomerCellRenderer(){return new li}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Ze.cb)(10),!(0,ei.V)(t,"Sequence space"))return e;const n=me(t,wo.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Be.uF.MONOMER,e.setTag(ge.gp.alphabet,t.getTag(ge.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Be.uF.MONOMER,o.setTag(ge.gp.alphabet,t.getTag(ge.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return wo.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new vt(wo.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Ct(wo.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,_e.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,wo.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=wo.seqHelper;return Ci(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=wo.seqHelper;return Ci(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Un()}static async manageLibrariesView(){await Wn()}static async manageMonomersView(){const e=await Jt.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await Wn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await On.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await Jt.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,Et.TE)()}static bioSubstructureFilter(){return new St._i(wo.seqHelper,wo.logger)}static bioSubstructureFilterTest(){return new St._i(wo.seqHelper,wo.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new ii(e,"webLogoLargeApp"),n=await wo.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new ii(e,"webLogoAggApp"),n=await wo.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new bi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await wo.files.readCsv("samples/HELM_empty_vals.csv"),n=new bi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,xe.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,xe.Hx)(wo.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,xe.Hx)(wo.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,r=e.rowIndex,s=n.getSeqHandler(i),a=t===ue.Hi.SEPARATOR?wo.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,wo.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await wo.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,_e.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await wo.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Co.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Dn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),wo.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await wo.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await Co.toAtomicLevel(e,n,!0,!1),(0,_e.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,_e.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?Co.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await Ci(i,n,t,pe.IDENTITY,wo.seqHelper)).get(0)}catch(e){const[t,n]=(0,be.AP)(e);throw wo.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Ze.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Co.initBio(),wo.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=wo.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,wo.rdKitModule,i);return r.semType=s.SEMTYPE.MOLECULE,r}(0,t,n,wo.monomerLib)}}fo([o.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),yo("design:type",Function),yo("design:paramtypes",[]),yo("design:returntype",Promise)],Co,"getMonomerLibHelper",null),fo([o.decorators.init({tags:["init"]}),yo("design:type",Function),yo("design:paramtypes",[]),yo("design:returntype",Promise)],Co,"initBio",null),fo([o.decorators.func({meta:{role:"tooltip"},tags:["tooltip"]}),bo(0,o.decorators.param({options:{semType:"Macromolecule"}})),yo("design:type",Function),yo("design:paramtypes",[s.Column]),yo("design:returntype",s.Widget)],Co,"sequenceTooltip",null),fo([o.decorators.func({}),yo("design:type",Function),yo("design:paramtypes",[String]),yo("design:returntype",Promise)],Co,"standardiseMonomerLibrary",null),fo([o.decorators.func({"top-menu":"Bio | Manage | Match with Monomer Library...",description:"Matches molecules in a column with monomers from the selected 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h=n(4870);const d="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,h.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then(()=>{setTimeout(()=>{this.grid.cell(d,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))},100)})}updateInputs(){const e=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,h.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",()=>this.editHelmLinkAction(),void 0,{style:{position:"relative",left:"95px"}});const t=r.DataFrame.create(1);t.columns.addNewString(d).init(e=>""),t.col(d).semType=this.col.semType,t.col(d).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK(async()=>{let e,n=this.units===a.Hi.HELM?t.get(d,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await g(n,this.col,this.seqHelper):p(n,this.col),this.col.dataFrame.filter.and(e)}).show()}}function p(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,r=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(e,n):e,o=r.BitSet.create(t.length);for(let n=0;n<t.length;n++){const r=t.get(n);(r.match(i)||r===e)&&o.set(n,!0,!1)}return o}async function g(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await f(t,n,!0);const o=r.Column.string("helm",1).init(t=>e);o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await c(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function f(e,t,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,s.cb)(10);const i=new Map,o=await c(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966(e,t,n){"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(7150);function s(e,t,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,u]=a(e,t,l,n,o);return s&&!c&&i.shell.warning(u),c}function a(e,t,n,r=[],s=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(r.length>0&&!r.some(e=>o.toUpperCase()==e.toUpperCase()))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map(e=>`"${e}"`).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some(t=>e.toUpperCase()==t.toUpperCase())&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map(e=>`"${e}"`).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139(e,t,n){"use strict";n.d(t,{HX:()=>h,J:()=>c,b9:()=>u,gN:()=>a,uF:()=>r});var i,o,r,s=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(o||(o={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(r||(r={}));const a="MSA";var l,c;!function(e){e.CELL_CHANGING="isCellChanging"}(l||(l={})),function(e){e.SEPARATOR="."}(c||(c={}));const u="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:s.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433(e,t,n){"use strict";n.d(t,{C:()=>d,r:()=>m});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(2738);let u=null,h=[];async function d(e,t){let n=e??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),d=s.notation;const p=o.divText("Current notation: "+d,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),g=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM,l.Hi.BILN],f=await c.$G.getProviderConstructors(),y=o.input.column("Column",{table:r.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),d=s.notation,d===l.Hi.HELM&&(v.value="/"),p.textContent="Current notation: 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m(n,t,e,i,o)}).show({x:350,y:100}),h.push(u.onClose.subscribe(e=>{h.forEach(e=>{e.unsubscribe()}),h=[],u=null})))}async function m(e,t,n,o,s){if(s){const t=e.dataFrame.columns.getUnusedName(`${s.notationName}(${e.name})`),n=i.Column.string(t,e.length);n.init(t=>{const n=e.get(t);try{return s.convertFromHelm(n,{})}catch(e){return console.error(`Error converting sequence at row ${t}: ${e instanceof Error?e.message:e}`),""}}),e.dataFrame.columns.add(n);const o=await r.functions.call("Bio:detectMacromolecule",{col:n});return o&&(n.semType=o),await r.data.detectSemanticTypes(e.dataFrame),n}{const i=t.getSeqHandler(e).convert(n,o);e.dataFrame.columns.add(i);const s=await r.functions.call("Bio:detectMacromolecule",{col:i});return s&&(i.semType=s),await r.data.detectSemanticTypes(e.dataFrame),i}}},6956(e,t,n){"use strict";n.d(t,{m:()=>o,x:()=>i});const i="|",o="H"},2582(e,t,n){"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.x).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA|CHEM|BLOB)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA|CHEM|BLOB)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=e.indexOf("}$"),n=e.substring(0,t+1),i=e.indexOf("$",t+2),r=e.substring(t+2,i),a=n.split("}|");for(let e=0;e<a.length-1;e++)a[e]=a[e]+"}";this.simplePolymers=a.map(e=>new s(e)),this.connectionList=new o(r),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>t-e).find(t=>e>=t);if(null==n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},8604(e,t,n){"use strict";n.d(t,{G:()=>i,V:()=>o});const i={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}},o={PEPTIDE:334,RNA:383,CHEM:0}},1619(e,t,n){"use strict";n.d(t,{D:()=>x});var i=n(4328),o=n(6082),r=n(7389),s=n(5749),a=n(2003),l=n(608),c=n(8152),u=n(966),h=n(4139),d=n(5072),m=n.n(d),p=n(7825),g=n.n(p),f=n(7659),y=n.n(f),b=n(5056),w=n.n(b),v=n(540),C=n.n(v),T=n(1113),A=n.n(T),E=n(6369),S={};S.styleTagTransform=A(),S.setAttributes=w(),S.insert=y().bind(null,"head"),S.domAPI=g(),S.insertStyleElement=C(),m()(E.A,S),E.A&&E.A.locals&&E.A.locals;var M=n(7150);async function x(e,t){return new Promise(async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const u=e.col?.dataFrame??i.shell.t;if(!u){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const d=e.col??u.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const m=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});m.setTooltip("Alignment method");const p=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${h.b9}`,"kalign-version"),f=r.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),w=r.inputs([f,y,p]),v=r.button("Alignment parameters",()=>{w.hidden=!w.hidden,[f,y,p].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");v.classList.add("msa-params-button"),w.hidden=!0,v.prepend(r.icons.settings(()=>null));const C=[m.root.style],T=[p.root.style,g.style];let A,E=d;const S=r.input.column("Sequence",{table:u,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(S.value=E);E=e,L.disabled=!1,A=await I(S.value,u,t,C,T,m,M,f,y,p,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});S.setTooltip("Sequences column to use for alignment");const M=r.input.column("Clusters",{table:u,value:e.clustersCol});M.nullable=!0;const x=r.dialog("MSA").add(S).add(M).add(m).add(w).add(v).add(b).add(g).onOK(async()=>{await P(S,u,A,n,a)}),L=x.getButton("OK");if(S.fireChanged(),e.col)return A=await I(e.col,u,t,C,T,m,M,f,y,p,b),void await P(S,u,A,n,a);x.show()})}async function P(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA 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e.reduce((e,t,n)=>e+`>sample${n+1}\n${t}\n`,"")}async function F(e,t,n=!1,i="",r=null,s,c,u,h){let d=t.toList();n&&(d=d.map(e=>R.clean(e).replace(/\-/g,"")));const m=t.length;r??=o.Column.string("Clusters",m).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const p=r.categories,g=r.getRawData(),f=new Array(p.length),y=new Array(p.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<m;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}B(y,p);const b=await new L(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),w=o.Column.string(i,m);for(let e=0;e<p.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=k(t);await b.fs.writeFile(O,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta 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c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,p,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,w=d.getRawData(),v=new Array(b.length),C=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}(0,s.aZ)(C,b);const T=new Array(y).fill(null);for(const e of v){if(!e||0===e.length)continue;const t=(await m(f.id,e,i,l,u,p)).Alignment;for(const e of t)T[parseInt(e.ID)]=Object.entries(e).filter(e=>!h.includes(e[0])).map(e=>"-"!==e[1]?e[1]:"").join(a.J.SEPARATOR)}const A=o.Column.fromStrings(n,T);return A.meta.units=r.Hi.SEPARATOR,A.setTag(r.gp.separator,a.J.SEPARATOR),A.setTag(r.gp.aligned,"SEQ.MSA"),A.setTag(r.gp.alphabet,r.YI.UN),A.setTag(r.gp.alphabetIsMultichar,"true"),A.semType=o.SEMTYPE.MACROMOLECULE,A}async function m(e,t,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok&&m){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!m){const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();if("pepsea-stderr"in p){const e=p["pepsea-stderr"];s?.warning(e)}return p}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c,aS:()=>h,wz:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(7150);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=u(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=h(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}function h(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{VN:()=>P,n5:()=>C,Ue:()=>S,Tc:()=>E,oP:()=>I,eN:()=>L});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(5749),g=n(7602),f=n(439),y=n(6882);var b=n(7150);function w(e,t,n){return Math.abs(e-t)<=n}var v,C,T=n(6307),A=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class E{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new E),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,A.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,T.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(v||(v={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var x;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(x||(x={}));const P=new class{render=20};class I extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:v.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:v.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:v.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:v.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:v.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:v.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:v.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:v.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:v.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:v.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:v.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:v.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:v.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:v.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:v.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:v.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:v.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:v.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:v.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:v.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:v.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:v.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(x.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(x.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,P.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(x.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(x.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(x.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){w(e,this.slider.minRange,.1)&&w(t,this.slider.maxRange,.1)&&w(n,this.slider.min,.1)&&w(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(x.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(x.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(x.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=x.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=x.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=x.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=x.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;w(n,this.positionWidth,.1)?this.render(x.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(x.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(x.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(x.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function L(e,t,n,i,o){let r=0,s=-1;for(;-1!=(s=n.findNext(s,!0));){const e=t.getSplitted(s),n=o.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===i&&r++}return r}},1687(e,t,n){"use strict";n.d(t,{_i:()=>E,AR:()=>A});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(5749),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),w=n(7150);class v extends m.O{seqHelper;emptyProps=new m.n("",void 0,w._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,w._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class T{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class E extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++E.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new S:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new T(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class S extends m.O{emptyProps=new m.n("",void 0,w._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,w._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new A("",void 0,w._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new A(e,this.props.separator,w._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new A(this.props.substructure,t,w._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new A("",void 0,w._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use strict";const{normalizeIPv6:i,removeDotSegments:o,recomposeAuthority:r,normalizeComponentEncoding:s,isIPv4:a,nonSimpleDomain:l}=n(4834),{SCHEMES:c,getSchemeHandler:u}=n(343);function h(e,t,n,i){const r={};return i||(e=p(d(e,n),n),t=p(d(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(r.scheme=t.scheme,r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(t.path?("/"===t.path[0]?r.path=o(t.path):(void 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i=n?Object.assign({scheme:"null"},n):{scheme:"null"},o=h(p(e,i),p(t,i),i,!0);return i.skipEscape=!0,d(o,i)},resolveComponent:h,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=d(s(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=d(s(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=d(s(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=d(s(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:d,parse:p};e.exports=g,e.exports.default=g,e.exports.fastUri=g},343(e,t,n){"use strict";const{isUUID:i}=n(4834),o=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu,r=["http","https","ws","wss","urn","urn:uuid"];function s(e){return!0===e.secure||!1!==e.secure&&!!e.scheme&&!(3!==e.scheme.length||"w"!==e.scheme[0]&&"W"!==e.scheme[0]||"s"!==e.scheme[1]&&"S"!==e.scheme[1]||"s"!==e.scheme[2]&&"S"!==e.scheme[2])}function a(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function l(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const c={scheme:"http",domainHost:!0,parse:a,serialize:l},u={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=s(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(s(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},h={http:c,https:{scheme:"https",domainHost:c.domainHost,parse:a,serialize:l},ws:u,wss:{scheme:"wss",domainHost:u.domainHost,parse:u.parse,serialize:u.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const n=e.path.match(o);if(n){const i=t.scheme||e.scheme||"urn";e.nid=n[1].toLowerCase(),e.nss=n[2];const 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${o}`)}}const w=[{name:"Valid Biln",seqs:["A-C(1,3)-G-G-H-A-V-E-A-K-Y-L-V-C(3,3)-S.G-I-V-E-A-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-Y","A-C(1,3)-G-G-H-A-V-E-A-K-Y-L-V-C(3,3)-S.G-I-V-E-A-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-Y","C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.C(1,1)(2,2)(3,3)","C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.[C](1,1)(2,2)(3,3)","D-T-H-F-P-I-C(1,3)-I-F-C(2,3)-C(3,3)-G-C(2,3)-C(4,3)-H-R-S-K-C(3,3)-G-M-C(4,3)-C(1,3)-K-T"],negative:!1},{name:"Simple Separator Neg",seqs:["meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me","Lys_Boc/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Thr_PO3H2/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Thr_PO3H2/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"],negative:!0},{name:"Valid Biln without cyclization",seqs:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-Tyr_Bn-dV-E-N-dV---Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-Aze-dV-E-N-dV---Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-meQ-dV-E-N-dV---Phe_4Me"],negative:!1}],v=[{name:"Linear",biln:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me"],helm:["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].[Chg].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$"]},{name:"Cyclic",biln:["C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.[C](1,1)(2,2)(3,3)","D-T-H-F-P-I-C(1,3)-I-F-C(2,3)-C(3,3)-G-C(2,3)-C(4,3)-H-R-S-K-C(3,3)-G-M-C(4,3)-C(1,3)-K-T","L-C(1,3)-G-S-H-L-V-E-A-L-Y-L-V-C(2,3)-G.G-I-V-E-Q-C(3,3)-C(1,3)-T-S-I-C(3,3)-S-L-Y-Q-L-E-N-Y-C(2,3)-N","H-Aib-E-G-T-F-T-S-D(2,3)-V-S-S-Y-L-E-G-Q-A-A-K(1,3)-E-F-I-A-W-L-V-R-G-R-G.C(2,3)-gGlu-G-G(1,2)","F(4,2).dI(1,1)(3,3)-Trp_Ome-Asp_OMe-Cys_Bn-meG-Phe_3Cl-dD-T-dI(4,3)-T-dK-aG-3Pal-xiIle-meD-Ala_tBu(1,2).L(2,1)-Pro_4Me3OH-S-NMe2Abz-Q-3Pal-xiIle-D-Hyp-Ala_tBu-dI(3,3)-Trp_Ome-Asp_OMe-N-meG-Phe_34diCl-Phe_34diCl(2,2)"],helm:["PEPTIDE1{C.C.S.W.P.A.R.C.L.H.Q.D.L.C.[NH2]}|PEPTIDE2{C}$PEPTIDE1,PEPTIDE2,14:R3-1:R3|PEPTIDE1,PEPTIDE2,8:R3-1:R2|PEPTIDE1,PEPTIDE2,2:R3-1:R1$$$V2.0","PEPTIDE1{D.T.H.F.P.I.C.I.F.C.C.G.C.C.H.R.S.K.C.G.M.C.C.K.T}$PEPTIDE1,PEPTIDE1,10:R3-13:R3|PEPTIDE1,PEPTIDE1,11:R3-19:R3|PEPTIDE1,PEPTIDE1,14:R3-22:R3|PEPTIDE1,PEPTIDE1,7:R3-23:R3$$$V2.0","PEPTIDE1{L.C.G.S.H.L.V.E.A.L.Y.L.V.C.G}|PEPTIDE2{G.I.V.E.Q.C.C.T.S.I.C.S.L.Y.Q.L.E.N.Y.C.N}$PEPTIDE1,PEPTIDE2,2:R3-7:R3|PEPTIDE2,PEPTIDE2,6:R3-11:R3|PEPTIDE1,PEPTIDE2,14:R3-20:R3$$$V2.0","PEPTIDE1{H.[Aib].E.G.T.F.T.S.D.V.S.S.Y.L.E.G.Q.A.A.K.E.F.I.A.W.L.V.R.G.R.G}|PEPTIDE2{C.[gGlu].G.G}$PEPTIDE1,PEPTIDE2,9:R3-1:R3|PEPTIDE1,PEPTIDE2,20:R3-4:R2$$$V2.0","PEPTIDE1{F}|PEPTIDE2{[dI].[Trp_Ome].[Asp_OMe].[Cys_Bn].[meG].[Phe_3Cl].[dD].T.[dI].T.[dK].[aG].[3Pal].[xiIle].[meD].[Ala_tBu]}|PEPTIDE3{L.[Pro_4Me3OH].S.[NMe2Abz].Q.[3Pal].[xiIle].D.[Hyp].[Ala_tBu].[dI].[Trp_Ome].[Asp_OMe].N.[meG].[Phe_34diCl].[Phe_34diCl]}$PEPTIDE1,PEPTIDE2,1:R2-9:R3|PEPTIDE2,PEPTIDE2,1:R1-16:R2|PEPTIDE2,PEPTIDE3,1:R3-11:R3|PEPTIDE3,PEPTIDE3,1:R1-17:R2$$$V2.0"]}],C=[{name:"Linear",biln:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me"],helm:["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].[Chg].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$"]},{name:"Cyclic",biln:["C-C(3,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(1,3)-NH2.C(1,3)(2,2)(3,1)","D-T-H-F-P-I-C(4,3)-I-F-C(1,3)-C(2,3)-G-C(1,3)-C(3,3)-H-R-S-K-C(2,3)-G-M-C(3,3)-C(4,3)-K-T","L-C(1,3)-G-S-H-L-V-E-A-L-Y-L-V-C(3,3)-G.G-I-V-E-Q-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-N","H-Aib-E-G-T-F-T-S-D(1,3)-V-S-S-Y-L-E-G-Q-A-A-K(2,3)-E-F-I-A-W-L-V-R-G-R-G.C(1,3)-gGlu-G-G(2,2)","F(1,2).dI(2,1)(3,3)-Trp_Ome-Asp_OMe-Cys_Bn-meG-Phe_3Cl-dD-T-dI(1,3)-T-dK-aG-3Pal-xiIle-meD-Ala_tBu(2,2).L(4,1)-Pro_4Me3OH-S-NMe2Abz-Q-3Pal-xiIle-D-Hyp-Ala_tBu-dI(3,3)-Trp_Ome-Asp_OMe-N-meG-Phe_34diCl-Phe_34diCl(4,2)"],helm:["PEPTIDE1{C.C.S.W.P.A.R.C.L.H.Q.D.L.C.[NH2]}|PEPTIDE2{C}$PEPTIDE1,PEPTIDE2,14:R3-1:R3|PEPTIDE1,PEPTIDE2,8:R3-1:R2|PEPTIDE1,PEPTIDE2,2:R3-1:R1$$$V2.0","PEPTIDE1{D.T.H.F.P.I.C.I.F.C.C.G.C.C.H.R.S.K.C.G.M.C.C.K.T}$PEPTIDE1,PEPTIDE1,10:R3-13:R3|PEPTIDE1,PEPTIDE1,11:R3-19:R3|PEPTIDE1,PEPTIDE1,14:R3-22:R3|PEPTIDE1,PEPTIDE1,7:R3-23:R3$$$V2.0","PEPTIDE1{L.C.G.S.H.L.V.E.A.L.Y.L.V.C.G}|PEPTIDE2{G.I.V.E.Q.C.C.T.S.I.C.S.L.Y.Q.L.E.N.Y.C.N}$PEPTIDE1,PEPTIDE2,2:R3-7:R3|PEPTIDE2,PEPTIDE2,6:R3-11:R3|PEPTIDE1,PEPTIDE2,14:R3-20:R3$$$V2.0","PEPTIDE1{H.[Aib].E.G.T.F.T.S.D.V.S.S.Y.L.E.G.Q.A.A.K.E.F.I.A.W.L.V.R.G.R.G}|PEPTIDE2{C.[gGlu].G.G}$PEPTIDE1,PEPTIDE2,9:R3-1:R3|PEPTIDE1,PEPTIDE2,20:R3-4:R2$$$V2.0","PEPTIDE1{F}|PEPTIDE2{[dI].[Trp_Ome].[Asp_OMe].[Cys_Bn].[meG].[Phe_3Cl].[dD].T.[dI].T.[dK].[aG].[3Pal].[xiIle].[meD].[Ala_tBu]}|PEPTIDE3{L.[Pro_4Me3OH].S.[NMe2Abz].Q.[3Pal].[xiIle].D.[Hyp].[Ala_tBu].[dI].[Trp_Ome].[Asp_OMe].N.[meG].[Phe_34diCl].[Phe_34diCl]}$PEPTIDE1,PEPTIDE2,1:R2-9:R3|PEPTIDE2,PEPTIDE2,1:R1-16:R2|PEPTIDE2,PEPTIDE3,1:R3-11:R3|PEPTIDE3,PEPTIDE3,1:R1-17:R2$$$V2.0"]}];async function T(t){const n=e.Column.fromList(e.TYPE.STRING,"col1",t);if(await l.functions.call("Bio:detectMacromolecule",{col:n}),n.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${n.semType}', units='${n.meta.units}'.`;throw new Error(e)}}async function A(n,i,o,r,s,a,u,h=null){const d=e.Column.fromList(e.TYPE.STRING,"seq",n),m=await l.functions.call("Bio:detectMacromolecule",{col:d});m&&(d.semType=m),(0,t.E3)(d.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(d.meta.units,o),(0,t.E3)(d.getTag(c.gp.aligned),r),(0,t.E3)(d.getTag(c.gp.alphabet),s),h&&(0,t.E3)(d.getTag(c.gp.separator),h);const p=i.getSeqHandler(d);(0,t.E3)(p.getAlphabetSize(),a),(0,t.E3)(p.getAlphabetIsMultichar(),u),p.isHelm()||((0,t.E3)(p.aligned,r),(0,t.E3)(p.alphabet,s))}async function E(e,t,n){const i=await e(),o=[];for(const r of i.columns.names())if(r in t){const i=t[r];try{await m(e,r,n,i.units,i.aligned,i.alphabet,i.alphabetSize,i.alphabetIsMultichar,i.separator)}catch(e){const t=e.toString();o.push(`Positive col '${r}' failed: ${t}`)}}else try{await d(e,r)}catch(e){const t=e.toString();o.push(`Negative col '${r}' failed: ${t}`)}if(o.length>0)throw new Error(o.join("\n"))}(0,t.L1)("detectors",()=>{let n;(0,t.gM)(async()=>{n=await(0,u.Q)()});const i={negEmpty:{csv:"id,col1\n1,\n2,\n3,\n4,\n5,",neg:["col1"]},negNum1:{csv:"col1\n1\n2\n3",neg:["col1"]},negNum2:{csv:"col1\n4\n5\n6\n7",neg:["col1"]},negNum3:{csv:"col1\n8\n9\n10\n11\n12",neg:["col1"]},negSmiles:{csv:"col1\nCCCCN1C(=O)CN=C(c2cc(F)ccc12)C3CCCCC3\nC1CCCCC1\nCCCCCC",neg:["col1"]},negSmilesWithSquareBrackets:{csv:"col1\nCl.c1ccc2nc3ccccc3cc2c1\nOc1cccc2cc3ccccc3cc12\n[SeH]c1ccc2ccccc2c1",neg:["col1"]},negFastaUnSingleChar:{csv:"col1\nAlanine\nCysteine\nAspartic acid\nGlutamic acid\nPhenylalanine",neg:["col1"]},fastaMsaSameLength:{csv:"seq\nFWPHEYFWPHEYYV\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1,void 0)}},fastaExtSameLength:{csv:"seq\nFW[Ac]PHEYFWPH\nYN[Re]VYNRQWYV\n[Me]EYVMPS[Et]",pos:{seq:new h(c.Hi.FASTA,"SEQ",c.YI.UN,16,!0,void 0)}},fastaMsaExtSameLength:{csv:"seq\nFW[Ac]PHEY[Re]WPH\nYN[Re]VYNR[Ac]WYV\n[Me]EYVMPSFW[Me]H",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.UN,14,!0,void 0)}},fastaMsaExtManyMinus:{csv:"seq\n[D-Tic]-------[D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]N[D-Orn][D-aThr]-[Phe_4Me]\n[Phe_2F]--------[Tyr_ab-dehydroMe][dV][Aca]N[D-Orn][D-aThr]-[Phe_4Me]\n[D-Tic]-[Hcy]QTWQ[Phe_4NH2][D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]----[Phe_4Me]",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.UN,17,!0,void 0)}},sepSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2",pos:{seq:new h(c.Hi.SEPARATOR,"SEQ.MSA",c.YI.UN,5,!0,"-")}},sepMsaSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2\nAca-A-Aca-A-A-A-meI-A-A-A-A-A-Aca-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2",pos:{seq:new h(c.Hi.SEPARATOR,"SEQ",c.YI.UN,5,!0,"-")}},helmSameLength:{csv:"seq\nPEPTIDE1{Ac(1).A.A.A.A.A.A.A.A.A.A.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ab(1).Y.V.K.H.P.F.W.R.W.Y.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ad(1).S.W.Y.C.K.H.P.M.W.A.A.A.A.C(1)-G-NH2}$$$$",pos:{seq:new h(c.Hi.HELM,null,null,19,void 0,void 0)}},fastaNonDigitAlphabet:{csv:'flagC\n"NMe-pyridazineH"\n"Pyrrolo[2,3-c]pyridazineH"',neg:["flagC"]}};for(const[o,r]of Object.entries(i))(0,t.t6)(`csvData2-${o}`,async()=>{const t=(s=o,async()=>{const t=i[s].csv,n=e.DataFrame.fromCsv(t);return await l.data.detectSemanticTypes(n),n});var s;for(const e of r.neg??[])await d(t,e);for(const[e,i]of Object.entries(r.pos??{}))await m(t,e,n,i.units,i.aligned,i.alphabet,i.alphabetSize,i.alphabetIsMultichar,i.separator)});const o=new class{csvFastaDna1="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC";fastaRna1="seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC";fastaPt1="seq\nFWPHEY\nYNRQWYV\nMKPSEYV";fastaUn="seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]DN\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]";sepDna="seq\nA*C*G*T*C*A*C*G*T*C\nC*A*G*T*G*T*C*A*G*T*G*T\nT*T*C*A*A*C*T*T*C*A*A*C";sepRna="seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C";sepPt="seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V";sepUn1="seq\nabc-dfgg-abc1-cfr3-rty-wert-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-cfr3-wert-rut12";sepUn2="seq\nabc/dfgg/abc1/cfr3/rty/wert/abc/dfgg/abc1/cfr3/rty/wert\nrut12/her2/rty/wert//abc/abc1/dfgg/rut12/her2/rty/wert//abc/abc1/dfgg\nrut12/rty/her2/abc/cfr3//wert/rut12/rut12/rty/her2/abc/cfr3//wert/rut12";sepMsaDna1="seq\nA-C--G-T--C-T-A-C--G-T--C-T\nC-A-C--T--G-T-C-A-C--T--G-T\nA-C-C-G-T-A-C-T-A-C-C-G-T-A-C-T";sepMsaUnWEmpty="seq\nm1-M-m3-mon4-mon5-N-T-MON8-N9-m1-M-m3-mon4-mon5-N-T-MON8-N9\nm1-mon2-m3-mon4-mon5-Num--MON8-N9-m1-mon2-m3-mon4-mon5-Num--MON8-N9\n\nmon1-M-mon3-mon4-mon5---MON8-N9-mon1-M-mon3-mon4-mon5---MON8-N9";sepComplex="seq\nAca-F-K(AEEA-AEEA-R-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-ARRA-W-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-AEEA-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2";fastaMsaDna1="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT";fastaMsaPt1="seq\nFWR-WYV-KHPFWR-WYV-KHP\nYNR-WYV-KHPYNR-WYV-KHP\nMWRSWY-CKHPMWRSWY-CKHP"},r={fastaPtCsv:"System:AppData/Bio/samples/FASTA_PT.csv",msaComplex:"System:AppData/Bio/samples/MSA.csv",fastaCsv:"System:AppData/Bio/samples/FASTA.csv",helmCsv:"System:AppData/Bio/samples/HELM.csv",peptidesComplex:"System:AppData/Bio/tests/peptides_complex_msa.csv",peptidesSimple:"System:AppData/Bio/tests/peptides_simple_msa.csv",testDemogCsv:"System:AppData/Bio/tests/testDemog.csv",testHelmCsv:"System:AppData/Bio/tests/testHelm.csv",testIdCsv:"System:AppData/Bio/tests/testId.csv",testSmilesCsv:"System:AppData/Bio/tests/testSmiles.csv",testSmiles2Csv:"System:AppData/Bio/tests/testSmiles2.csv",testSmilesShort:"System:AppData/Bio/tests/testSmilesShort.csv",testActivityCliffsCsv:"System:AppData/Bio/tests/testActivityCliffs.csv",testCerealCsv:"System:AppData/Bio/tests/testCereal.csv",testUnichemSources:"System:AppData/Bio/tests/testUnichemSources.csv",testDmvOffices:"System:AppData/Bio/tests/testDmvOffices.csv",testAlertCollection:"System:AppData/Bio/tests/testAlertCollection.csv",testSpgi100:"System:AppData/Bio/tests/testSpgi100.csv",testSpgi:"System:AppData/Bio/tests/SPGI-derived.csv",testUrl:"System:AppData/Bio/tests/testUrl.csv",fasta_negative_words:"System:AppData/Bio/tests/fasta_negative_words.csv"},s={};function a(e,t=p){return async()=>(e in s||(s[e]=(async()=>await t(r[e]))().catch(t=>{throw delete s[e],t})),s[e])}async function p(t){const n=await l.dapi.files.readAsText(t);return e.DataFrame.fromCsv(n)}const g=t=>async()=>{const n=o[t],i=e.DataFrame.fromCsv(n);return await l.data.detectSemanticTypes(i),i};(0,t.t6)("NegativeStartEnd",async()=>{await T(["START","END"])}),(0,t.t6)("NegativeStartEndIntermediate",async()=>{await T(["START","END","INTERMEDIATE"])}),(0,t.t6)("FastaDna1",async()=>{await m(g("csvFastaDna1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.DNA,4,!1)}),(0,t.t6)("FastaRna1",async()=>{await m(g("fastaRna1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.RNA,4,!1)}),(0,t.t6)("FastaPt1",async()=>{await m(g("fastaPt1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.PT,20,!1)}),(0,t.t6)("FastaPtGaps",()=>A(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEYV"],n,c.Hi.FASTA,"SEQ",c.YI.PT,20,!1)),(0,t.t6)("FastaPtGapsMsa",()=>A(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEY"],n,c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1)),(0,t.t6)("FastaUn",async()=>{await m(g("fastaUn"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.UN,12,!0)}),(0,t.t6)("FastaMsaDna1",async()=>{await m(g("fastaMsaDna1"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.DNA,4,!1)}),(0,t.t6)("FastaMsaPt1",async()=>{await m(g("fastaMsaPt1"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1)}),(0,t.t6)("SepDna",async()=>{await m(g("sepDna"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.DNA,4,!1,"*")}),(0,t.t6)("SepRna",async()=>{await m(g("sepRna"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.RNA,4,!1,"*")}),(0,t.t6)("SepPt",async()=>{await m(g("sepPt"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.PT,20,!1,"-")}),(0,t.t6)("SepUn1",async()=>{await m(g("sepUn1"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.UN,8,!0,"-")}),(0,t.t6)("SepUn2",async()=>{await m(g("sepUn2"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.UN,9,!0,"/")}),(0,t.t6)("SepMsaN1",async()=>{await m(g("sepMsaDna1"),"seq",n,c.Hi.SEPARATOR,"SEQ.MSA",c.YI.DNA,4,!1,"-")}),(0,t.t6)("SepMsaUnWEmpty",async()=>{await 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d(o("fastaUnMsa1LikelyName"),"seq")})}),(0,t.L1)("detectorsBenchmark",()=>{let n,i;async function o(o,s,a,l,u,h){return await async function(o){const d=await(async()=>{const t=function(t,n,i,o,r){let s;switch(t){case c.Hi.FASTA:s=e=>{let t="";for(let n=0;n<e.length;n++){const i=e[n];t+=1==i.length?i:`[${i}]`}return t};break;case c.Hi.SEPARATOR:s=(e,t)=>e.join(t);break;default:throw new Error(`Not supported notation '${t}'.`)}const a=(e,t)=>{const n=new Array(t);for(let i=0;i<t;i++)n[i]=e[Math.floor(Math.random()*e.length)];return s(n,r)},l=Array(o);for(let e=0;e<o;e++)l[e]=a(n,i);return e.Column.fromStrings("seq",l)}(s,[...(0,c.Qf)(a)],l,u,h),n=i.prepare({col:t});return r(n),n})(),m=Date.now(),p=r(d),g=Date.now();(function(e,i){const o=n.getSeqHandler(e);(0,t.E3)(e.semType===i.semType,!0),(0,t.E3)(o.notation===i.notation,!0),(0,t.E3)(o.alphabet===i.alphabet,!0),(0,t.E3)(o.separator===i.separator,!0)})(p,{semType:e.SEMTYPE.MACROMOLECULE,notation:s,alphabet:a,separator:h});const 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S=n(608),M=n(1619);async function x(n,i){const o=e.DataFrame.fromCsv(n);await l.data.detectSemanticTypes(o);const r=e.DataFrame.fromCsv(i),s=o.getCol("seq");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const a=r.getCol("seq"),c=await(0,S.eE)(o,s,!0);(0,t.J6)(c.toList(),a.toList())}(0,t.L1)("MSA",async()=>{let n;async function i(i,o,r,s,a,u){const h=e.DataFrame.fromCsv(i);await l.data.detectSemanticTypes(h);const d=e.DataFrame.fromCsv(o).getCol("seq"),m=h.getCol("seq");(0,t.E3)(m.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(m.meta.units,r),a&&(0,t.E3)(m.getTag(c.gp.alphabet),a);const p=await(0,M.D)({col:m,pepsea:{method:u}},n);(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,s),(0,t.E3)(p.getTag(c.gp.aligned),"SEQ.MSA"),a&&(0,t.E3)(p.getTag(c.gp.alphabet),a),(0,t.J6)(p.toList(),d.toList())}(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("isCorrect",async()=>{await 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docker"}),(0,t.t6)("isCorrectHelmLong",async()=>{await i("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2}$$$$\n PEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\n PEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2\n meI.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me.\n Lys_Boc.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me.",c.Hi.HELM,c.Hi.SEPARATOR,void 0,"mafft")},{timeout:8e4,skipReason:"Fails in docker"}),(0,t.t6)("isCorrectSeparator",async()=>{await i("seq\n F-W-P-H-E-Y\n Y-N-R-Q-W-Y-V\n M-K-P-S-E-Y-V","seq\n FWPHEY-\n YNRQWYV\n MKPSEYV",c.Hi.SEPARATOR,c.Hi.FASTA,c.YI.PT)}),(0,t.t6)("isCorrectSeparatorLong",async()=>{await i("seq\n 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H=n(4139),D=n(4356);async function k(e,n){const i=(0,c.J9)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(i)} .`),(0,t.J6)(I().count(0).take(i.length).map(e=>i.getOriginal(e)).toArray(),n)}async function F(e,n){const i=(0,L.qp)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(i)} .`),(0,t.J6)(I().count(0).take(i.length).map(e=>i.getOriginal(e)).toArray(),n)}(0,t.L1)("splitters",async()=>{(0,t.gM)(async()=>{}),(0,t.Pl)(async()=>{});const e=["M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",["M","MeI","Y","K","E","T","L","L","MeF","P","K","T","D","F","P","M","R","G","G","L","MeA"]],n=["[meI][Pip][dK][Thr_PO3H2][L-hArg(Et,Et)][D-Tyr_Et][Tyr_ab-dehydroMe][dV]EN[D-Orn][D-aThr][Phe_4Me]",["meI","Pip","dK","Thr_PO3H2","L-hArg(Et,Et)","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],i=["PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],o=["PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.D-Dap.dV.E.N.pnG.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],r=["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[D-Dap].[dV].E.N.[pnG].[Phe_4Me]}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],s=["RNA1{R(U)P.R(T)P.R(G)P.R(C)P.R(A)}$$$$",["R(U)P","R(T)P","R(G)P","R(C)P","R(A)"]],a=["RNA1{P.R(U)P.R(T)}$$$$",["P","R(U)P","R(T)"]],l=["RNA1{P.R(U).P.R(T)}$$$$",["P","R(U)","P","R(T)"]];(0,t.t6)("fastaMulti",async()=>{await 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r=l.shell.addTableView(o);await O(r.grid),(0,t.E3)(r.grid.dataFrame.id,e.id)}),(0,t.t6)("getHelmMonomers",async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await l.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],i=t.getCol("HELM"),o=await l.functions.call("Bio:getHelmMonomers",{sequence:i}),r=n.filter(e=>!o.includes(e)),s=o.filter(e=>!n.includes(e));if(r.length>0||s.length){const e=[];throw r.length>0&&e.push(`Missed monomers ${JSON.stringify(r)}.`),s.length>0&&e.push(`Unexpected monomers ${JSON.stringify(s)}.`),new Error(e.join(" "))}})});var G=n(8604);(0,t.L1)("monomerLibraries",()=>{let e,n=null;(0,t.gM)(async()=>{e=await(0,_.pj)(),n=(0,D.u)()}),(0,t.Pl)(async()=>{await(0,D.E)(n)}),(0,t.t6)("default",async()=>{await(0,D.E)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadMonomerLib(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)}),(0,t.t6)("forTests",async()=>{await e.loadMonomerLibForTests(),function(e,t){const n=t,i=e.getSummaryObj();for(const e in n)n[e]||delete n[e];for(const e in i)i[e]||delete i[e];if(0==Object.keys(n).length&&0!=Object.keys(i).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(n).length&&0==Object.keys(i).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,o.Xk)(i,n),(0,o.Xk)(n,i)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(n)} does not match actual ${JSON.stringify(i)}.`)}}(e.getMonomerLib(),G.V)}),(0,t.t6)("empty",async()=>{const n=await(0,D.u)();let i=await e.getAvaliableLibraryNames();0===i.length&&(await e.refreshValidLibraryLists(),i=await e.getAvaliableLibraryNames()),n.exclude=i,n.explicit=[],await(0,D.E)(n),await e.loadMonomerLib(!0);const o=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===o.length,!0)}),(0,t.t6)("override",async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},i=e.getMonomerLib(),o=i.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null==o,!0,`Unexpectedly found monomer '${n.symbol}' `);const r=i.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);r&&(r.lib=void 0),(0,t.Xk)(r,n)})});var B=n(7389),V=n(1757),U=n.n(V),W=n(1858),q=n(6873),Y=n(5433);async function j(n,i){const o=n(),r=e.DataFrame.fromColumns(o);await l.data.detectSemanticTypes(r);const s=Date.now(),a=(r.columns.byName("MSA"),l.shell.addTableView(r));await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,r.id);const c=Date.now()-s;console.log(`Performance test: ${i}: ${c}ms`)}(0,t.L1)("renderers",()=>{let n;(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("long sequence performance ",async()=>{await j(()=>(0,q.dW)(1e4),"Long sequences")}),(0,t.t6)("many sequence performance",async()=>{await j(q.fD,"Many sequences")}),(0,t.t6)("rendererMacromoleculeFasta",async()=>{await async function(){const n=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),i=e.DataFrame.fromCsv(n),o=i.getCol("Sequence"),r=await l.functions.call("Bio:detectMacromolecule",{col:o});r&&(o.semType=r);const s=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(s.grid),(0,t.E3)(s.grid.dataFrame.id,i.id);const a=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(a,"sequence")}()}),(0,t.t6)("rendererMacromoleculeSeparator",async()=>{await async function(){const n=await l.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),i=e.DataFrame.fromCsv(n),o=i.getCol("sequence"),r=await l.functions.call("Bio:detectMacromolecule",{col:o});r&&(o.semType=r);const s=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(s.grid),(0,t.E3)(s.grid.dataFrame.id,i.id);const a=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(a,"sequence")}()}),(0,t.t6)("rendererMacromoleculeDifference",async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=H.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(o.grid),(0,t.E3)(o.grid.dataFrame.id,i.id);const r=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(r,H.uF.MACROMOLECULE_DIFFERENCE)}()}),(0,t.t6)("afterMsa",async()=>{await async function(){const i=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),o=(await l.functions.call("Bio:importFasta",{fileContent:i}))[0],r=o.getCol("sequence"),s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=l.shell.addTableView(o);await l.data.detectSemanticTypes(o),console.log("Bio: tests/renderers/afterMsa, table view"),await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${r.semType}", units="${r.meta.units}", cell.renderer="${r.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(r.meta.units,c.Hi.FASTA),(0,t.E3)(r.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(r.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(r.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,M.D)({col:r},n);await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()}),(0,t.t6)("afterConvert",async()=>{await async function(){const i=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),o=e.DataFrame.fromCsv(i),r=o.getCol("sequence"),s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=l.shell.addTableView(o);await l.data.detectSemanticTypes(o);const u=await(0,Y.r)(r,n,c.Hi.SEPARATOR,"/");await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id);const h=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(h,"sequence"),n.getSeqHandler(u)}()}),(0,t.t6)("afterConvertToHelm",async()=>{await async function(){const i=await l.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),o=l.shell.addTableView(i);await O(o.grid),await i.meta.detectSemanticTypes(),await l.data.detectSemanticTypes(i);const r=i.getCol("sequence"),s=n.getSeqHandler(r).convert(c.Hi.HELM);i.columns.add(s),await O(o.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()}),(0,t.t6)("selectRendererBySemType",async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=H.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]);l.shell.addTableView(i),await(0,t.cb)(100);const o=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==o)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${o}' instead of correct 'MacromoleculeDifference'.`)}()}),(0,t.t6)("scatterPlotTooltip",async()=>{await async function(){const n=e.DataFrame.fromCsv(i);n.currentRowIdx=0;const o=l.shell.addTableView(n);await n.meta.detectSemanticTypes(),await l.data.detectSemanticTypes(n);const r=n.plot.scatter({x:"x",y:"y"});o.dockManager.dock(r,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(r.onAfterDrawScene,()=>{},()=>{r.invalidateCanvas()},1e3),O(o.grid,500)]);const s=r.root.getBoundingClientRect(),a=r.worldToScreen(1,0),c=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:s.left+a.x,clientY:s.top+a.y}),u=U()(r.root).find("canvas").get()[0];await(0,t.PE)(e.debounce((0,W.fromEvent)(u,"mousemove"),200),()=>{Re.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(U()(B.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(r.hitTest(a.x,a.y),1)},()=>{u.dispatchEvent(c)},500),await O(o.grid,500)}()});const i="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"});var K=n(6882);(0,t.L1)("renderers: monomerPlacer",()=>{let n,i;(0,t.gM)(async()=>{n=await(0,_.pj)(),i=await(0,D.u)(),await n.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(i),await n.loadMonomerLib(!0)});const o={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:190},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,i]of Object.entries(o))(0,t.t6)(`getPosition-${n}`,async()=>{const t=e.DataFrame.fromCsv(i.csv);await l.data.detectSemanticTypes(t);const n=t.getCol("seq"),o=new K.Jy(null,n,Re.logger,3,()=>({font:"12px monospace",fontCharWidth:7,separatorWidth:12,monomerToShort:c.zS}));await o.init();const r=i.testList;for(let e=0;e<n.length;++e)o.getCellMonomerLengths(e,1e4);const s=[];for(const[e,t]of I().enumerate(r)){const t={pos:o.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&s.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(s.length>0)throw new Error("Test failed error(s):\n"+s.join(", \n"))});const r=[10,20,30,40,50,60],s={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(s))(0,t.t6)("hitBounds-"+e,async()=>{const e=(0,K.Bb)(r,n.x);(0,t.E3)(e,n.tgt)});const a={mono1:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6/m7/m8/m9\nn1/m2/n3/m4/n5/m6/n7/m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGaps:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGapColumn:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5///n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,180,206,232]}}};for(const[n,i]of Object.entries(a))(0,t.t6)(`getCellMonomerLengths-${n}`,async()=>{const n=e.DataFrame.fromCsv(i.src.csv);await l.data.detectSemanticTypes(n);const o=n.getCol("seq"),r=new K.Jy(null,o,Re.logger,3,()=>({fontCharWidth:7,font:"12px monospace",separatorWidth:12,monomerToShort:c.zS}));await r.init();const s=r.getCellMonomerLengths(0,1e3)[1];(0,t.J6)(s,i.tgt.lengths)})}),(0,t.L1)("converters",()=>{let n,i;(0,t.gM)(async()=>{n=await(0,u.Q)()}),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(i||(i={}));const o={[i.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[i.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[i.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[i.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[i.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[i.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[i.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[i.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[i.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[i.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[i.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[i.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[i.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[i.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[i.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[i.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[i.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[i.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},r=new Set(Object.values(c.gp));async function s(t){const n=o[t],i=e.DataFrame.fromCsv(n);return await l.data.detectSemanticTypes(i),i}function a(e,i){if(e===c.Hi.SEPARATOR&&!i)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(o){const r=n.getSeqHandler(o).convert(e,i);return(0,t.E3)(r.meta.units,e),r}}async function h(e,i,o){const a=(await s(e)).getCol("seq"),l=i(a),u=(await s(o)).getCol("seq");(0,t.J6)(l.toList(),u.toList());const h=n.getSeqHandler(a),d=n.getSeqHandler(l);for(const[e,n]of Object.entries(u.tags)){if(!r.has(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const i=l.getTag(e);(0,t.E3)(i,n,`Tag '${e}' expected value '${n}' is not equal to actual '${i}'.`)}}(0,t.t6)("testFastaPtToSeparator",async()=>{await h(i.fastaPt,a(c.Hi.SEPARATOR,"-"),i.separatorPt)}),(0,t.t6)("testFastaDnaToSeparator",async()=>{await h(i.fastaDna,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testFastaRnaToSeparator",async()=>{await h(i.fastaRna,a(c.Hi.SEPARATOR,"*"),i.separatorRna)}),(0,t.t6)("testFastaGapsToSeparator",async()=>{await h(i.fastaGaps,a(c.Hi.SEPARATOR,"/"),i.separatorGaps)}),(0,t.t6)("testFastaUnToSeparator",async()=>{await h(i.fastaUn,a(c.Hi.SEPARATOR,"-"),i.separatorUn)}),(0,t.t6)("testFastaPtToHelm",async()=>{await h(i.fastaPt,a(c.Hi.HELM),i.helmPt)}),(0,t.t6)("testFastaDnaToHelm",async()=>{await h(i.fastaDna,a(c.Hi.HELM),i.helmDna)}),(0,t.t6)("testFastaRnaToHelm",async()=>{await h(i.fastaRna,a(c.Hi.HELM),i.helmRna)}),(0,t.t6)("testFastaGapsToHelm",async()=>{await h(i.fastaGaps,a(c.Hi.HELM),i.helmGaps)}),(0,t.t6)("testSeparatorPtToFasta",async()=>{await h(i.separatorPt,a(c.Hi.FASTA),i.fastaPt)}),(0,t.t6)("testSeparatorDnaToFasta",async()=>{await h(i.separatorDna,a(c.Hi.FASTA),i.fastaDna)}),(0,t.t6)("testSeparatorRnaToFasta",async()=>{await h(i.separatorRna,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testSeparatorGapsToFasta",async()=>{await h(i.separatorGaps,a(c.Hi.FASTA),i.fastaGaps)}),(0,t.t6)("testSeparatorUnToFasta",async()=>{await h(i.separatorUn,a(c.Hi.FASTA),i.fastaUn)}),(0,t.t6)("testSeparatorPtToHelm",async()=>{await h(i.separatorPt,a(c.Hi.HELM),i.helmPt)}),(0,t.t6)("testSeparatorDnaToHelm",async()=>{await h(i.separatorDna,a(c.Hi.HELM),i.helmDna)}),(0,t.t6)("testSeparatorRnaToHelm",async()=>{await h(i.separatorRna,a(c.Hi.HELM),i.helmRna)}),(0,t.t6)("testSeparatorGapsToHelm",async()=>{await h(i.separatorGaps,a(c.Hi.HELM),i.helmGaps)}),(0,t.t6)("testHelmDnaToFasta",async()=>{await h(i.helmDna,a(c.Hi.FASTA),i.fastaDna)}),(0,t.t6)("testHelmRnaToFasta",async()=>{await h(i.helmRna,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testHelmPtToFasta",async()=>{await h(i.helmPt,a(c.Hi.FASTA),i.fastaPt)}),(0,t.t6)("testHelmUnToFasta",async()=>{await h(i.helmUn,a(c.Hi.FASTA),i.fastaUn)}),(0,t.t6)("testHelmDnaToSeparator",async()=>{await h(i.helmDna,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testHelmRnaToSeparator",async()=>{await h(i.helmRna,a(c.Hi.SEPARATOR,"*"),i.separatorRna)}),(0,t.t6)("testHelmPtToSeparator",async()=>{await h(i.helmPt,a(c.Hi.SEPARATOR,"-"),i.separatorPt)}),(0,t.t6)("testHelmUnToSeparator",async()=>{await h(i.helmUn,a(c.Hi.SEPARATOR,"-"),i.separatorUn)}),(0,t.t6)("testHelmLoneRibose",async()=>{await h(i.helmLoneRibose,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testHelmLoneDeoxyribose",async()=>{await h(i.helmLoneDeoxyribose,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testHelmLonePhosphorus",async()=>{await h(i.helmLonePhosphorus,a(c.Hi.FASTA),i.fastaRna)});for(const e of v)(0,t.t6)(`testBilnToHelm_${e.name}`,async()=>{await y(e.biln,e.helm,n)});for(const e of C)(0,t.t6)(`testHelmToBiln_${e.name}`,async()=>{await b(e.helm,e.biln,n)})});var z=n(3516);(0,t.L1)("fastaFileHandler",()=>{const n=["description:1","description:2","description:3","description:4"],i=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function o(e){const o=new z.m(e),r=o.descriptionsArray,s=o.sequencesArray;(0,t.J6)([r,s],[n,i])}(0,t.t6)("testNormalFormatting",async()=>{o(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")}),(0,t.t6)("testExtraSpaces",async()=>{o(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n 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o=e.DataFrame.fromCsv(i).getCol("seq");o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=c.Hi.FASTA,o.setTag(c.gp.alphabet,"UN"),o.setTag(c.gp.alphabetSize,"11"),o.setTag(c.gp.alphabetIsMultichar,"true"),o.setTag(c.gp.aligned,"SEQ");const[r,s]=(0,ie.l)(o,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(r,!1)}),(0,t.t6)("testGetActionFunctionMeta",async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find(e=>"sequence"==e.name)})}),(0,t.L1)("similarity/diversity",async()=>{(0,t.t6)("similaritySearchViewer",async()=>{await async function(){const n=await Re.files.readAsText("tests/sample_MSA_data.csv"),i=e.DataFrame.fromCsv(n);await l.data.detectSemanticTypes(i);const o=l.shell.addTableView(i),r=o.dataFrame.getCol("MSA");(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const s=await o.dataFrame.plot.fromType("Sequence Similarity Search");let 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created",100);(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.scores.get(0),e.FLOAT_NULL),(0,t.E3)(c.idxs.get(0),0),(0,t.E3)(c.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(c.scores.get(1).toFixed(2),"0.10"),(0,t.E3)(c.idxs.get(1),7),(0,t.E3)(c.molCol.get(1),"/D-Tyr_Et/meQ/dV/E/N/dV///Phe_4Me"),o.dataFrame.currentRowIdx=1,await(0,t.bk)(()=>1===c.targetMoleculeIdx,"Target molecule has not been changed",5e3),await(0,t.bk)(()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===c.molCol.get(0),"Incorrect first similar molecule",5e3)}()}),(0,t.t6)("diversitySearchViewer",async()=>{await async function(){const n=await Re.files.readAsText("tests/sample_MSA_data.csv"),i=e.DataFrame.fromCsv(n),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i);const r=o.dataFrame.getCol("MSA");(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const s=await o.dataFrame.plot.fromType("Sequence Diversity Search");let a=!1;if(s.computeCompleted.subscribe(e=>{e&&(a=!0)}),o.dockManager.dock(s,e.DOCK_TYPE.DOWN,null,"Diversity"),await s.renderPromise,await(0,t.bk)(()=>void 0!==oe(o,"Sequence Diversity Search"),"Sequence Diversity Search viewer has not been created",100),!s.initialized)throw new Error("The viewer is not initialized.");if(!s.targetColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!s.beforeRender())throw new Error("The viewer is not able to render.");if(!s.computeRequested)throw new Error("The viewer has not compute requested even.");if(!a)throw new Error("The viewer has not compute completed.");const c=s;await(0,t.bk)(()=>0!==c.root.getElementsByClassName("d4-grid").length,"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.initialized,!0),(0,t.E3)(c.renderMolIds.length>0,!0)}()})});var re=n(1687),se=n(4574);(0,t.L1)("bio-substructure-filters",async()=>{let n,i,o;async function r(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const i=new re._i(n,Re.logger);return i.attach(t),i.applyState({columnName:e}),i.column=t.col(e),i.columnName=e,i}(0,t.gM)(async()=>{n=await(0,u.Q)(),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)}),(0,t.t6)("fasta",async()=>{const e=await $("tests/filter_FASTA.csv");await l.data.detectSemanticTypes(e);const i=new re._i(n,Re.logger);i.attach(e),await i.awaitRendered();try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"FastaBioFilter");const n=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new se.n("MD",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,3),(0,t.E3)(i.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{i.detach()}await i.awaitRendered()}),(0,t.t6)("separator",async()=>{const e=await $("tests/filter_MSA.csv"),i=new re._i(n,Re.logger);await l.data.detectSemanticTypes(e),i.attach(e),await i.awaitRendered();try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter");const n=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("meI",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,7),(0,t.E3)(i.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("/meI",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("meI-hHis","-",Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,7),(0,t.E3)(i.dataFrame.filter.get(2),!1)}finally{i.detach()}await i.awaitRendered()}),(0,t.t6)("helm-dialog",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e="Bio tests: substructureFilters/helm-dialog",i=await $("tests/filter_HELM.csv"),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await i.meta.detectSemanticTypes(),Re.logger.debug(`${e}, filter attaching.`);const r=new re._i(n,Re.logger);r.attach(i);const s=B.dialog("Test filters").add(r.root).show();await r.awaitRendered();try{const n=r.bioFilter;(0,t.E3)(null!==r.bioFilter,!0,"bioFilter is not created"),Re.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(i.onRowsFiltered,()=>{},()=>{n.props=new se.n("PEPTIDE1{A.C}$$$$V2.0",void 0,Re.logger)},2e4),Re.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(r.dataFrame.filter.trueCount,1),(0,t.E3)(r.dataFrame.filter.toBinaryString(),"0001"),Re.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(i.onRowsFiltered,()=>{},()=>{n.props=new se.n("PEPTIDE1{C}$$$$V2.0",void 0,Re.logger)},2e4),setTimeout(()=>o.grid.invalidate(),500),await O(o.grid),await(0,t.cb)(1e3),Re.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(r.dataFrame.filter.trueCount,2),(0,t.E3)(r.dataFrame.filter.toBinaryString(),"1001")}finally{s.close()}await r.awaitRendered(),await(0,t.cb)(3e3)}},{}),(0,t.t6)("helm-view",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await $("tests/filter_HELM.csv");e.getCol("HELM string"),await l.data.detectSemanticTypes(e);const t=l.shell.addTableView(e);t.getFiltersGroup(),await O(t.grid)}}),(0,t.t6)("sync-fasta",async()=>{const e=await Re.files.readCsv("tests/filter_FASTA.csv");await l.data.detectSemanticTypes(e);const n=await r("fasta",e),i=await r("fasta",e);await Promise.all([n.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(i.bioFilter.type,"FastaBioFilter");const o=n.bioFilter,r=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{o.props=new se.n("MD",void 0,Re.logger)},1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(r.props.substructure,"MD")}finally{n.detach(),i.detach()}await Promise.all([n.awaitRendered(),i.awaitRendered()])}),(0,t.t6)("sync-msa",async()=>{const e=await Re.files.readCsv("tests/filter_MSA.csv");await l.data.detectSemanticTypes(e);const n="hHis-Aca",i=await r("MSA",e),o=await r("MSA",e);await Promise.all([i.awaitRendered(),o.awaitRendered()]);try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(!!o.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(o.bioFilter.type,"SeparatorBioFilter");const r=i.bioFilter,s=o.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{r.props=new re.AR(n,"-",Re.logger)},1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(s.props.substructure,n),(0,t.E3)(s.props.separator,"-")}finally{i.detach(),o.detach()}await Promise.all([i.awaitRendered(),o.awaitRendered()])}),(0,t.t6)("sync-helm",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await Re.files.readCsv("tests/filter_HELM.csv");await l.data.detectSemanticTypes(e);const n=l.shell.addTableView(e),i="PEPTIDE1{A.C}$$$$V2.0",o=1,s=await r("HELM string",e),a=await r("HELM string",e),c=B.dialog("Test filters").add(s.root).add(a.root).show();await Promise.all([s.awaitRendered(),a.awaitRendered()]);try{(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(!!a.bioFilter,!0),(0,t.E3)(s.bioFilter.type,"HelmBioFilter"),(0,t.E3)(a.bioFilter.type,"HelmBioFilter");const r=s.bioFilter,l=a.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{r.props=new se.n(i,void 0,Re.logger)},6e4,"await onRowsFiltered"),await O(n.grid),Re.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*s.debounceTime),Re.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,o),await s.awaitRendered(),(0,t.E3)(l.props.substructure,i)}finally{s.detach(),a.detach(),c.close()}await Promise.all([s.awaitRendered(),a.awaitRendered()]),await O(n.grid),await(0,t.cb)(3e3)}}),(0,t.t6)("two-columns-fasta",async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await l.data.detectSemanticTypes(n);const i=l.shell.addTableView(n),o="seq1",r="CGGCTG",s=n.getCol("trueSeq1").toList(),a="seq2",c="GCATT",u=n.getCol("trueSeq2").toList(),h=[{type:"Bio:bioSubstructureFilter",columnName:o},{type:"Bio:bioSubstructureFilter",columnName:a}],d=await n.plot.fromType(e.VIEWER.FILTERS,{filters:h});i.dockManager.dock(d,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid);const m=d.filters[0],p=d.filters[1];(0,t.E3)(m.column.name,o),(0,t.E3)(p.column.name,a);const g=m.bioFilter,f=p.bioFilter;await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n(r,void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n("",void 0,Re.logger)},1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,s.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),s.map(e=>e.toString()).join("")),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n("",void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n(c,void 0,Re.logger)},1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),u.map(e=>e.toString()).join("")),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n("",void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n("",void 0,Re.logger)},1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n(r,void 0,Re.logger)},5e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n(c,void 0,Re.logger)},5e3,"testEvent onRowsFiltered on both");const y=I().count(0).take(n.rowCount).map(e=>s[e]*u[e]).toArray();(0,t.E3)(n.filter.trueCount,y.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),y.map(e=>e.toString()).join("")),await Promise.all([m.awaitRendered(),p.awaitRendered(),O(i.grid)])},{skipReason:"Inconsistent behavior of test"}),(0,t.t6)("reset-fasta",async()=>{const n=await $("tests/filter_FASTA.csv"),i=l.shell.addTableView(n);await l.data.detectSemanticTypes(n),await n.meta.detectSemanticTypes();const o="MD",r=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});i.dockManager.dock(r,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid);const s=r.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{s.props=new se.n(o,void 0,Re.logger)},1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(s.props.substructure,o),(0,t.E3)(s.substructureInput.value,o),U()(r.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await O(i.grid),(0,t.E3)(s.props.substructure,""),(0,t.E3)(s.substructureInput.value,"")}),(0,t.t6)("reopen",async()=>{const n=await Re.files.readCsv("tests/filter_FASTA.csv"),i=l.shell.addTableView(n);await l.data.detectSemanticTypes(n),await n.meta.detectSemanticTypes();const o=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],r=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(r,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid),r.close(),await O(i.grid);const s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid)},{})});var ae=n(8152);class le{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var ce=n(9192);(0,t.L1)("PepSeA",()=>{(0,t.t6)("Basic alignment",async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),i=await(0,ae.GD)(n,n.getCol("HELM"),"msa(HELM)"),o=n.getCol("MSA");for(let e=0;e<i.length;++e)(0,t.E3)(i.get(e)==o.get(e),!0)},{timeout:6e4,skipReason:"Fails in docker"}),(0,t.t6)("stderr",async()=>{const n=new le,i=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),o=await(0,ae.GD)(i,i.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),r=i.getCol("MSA");(0,t.J6)(o.toList(),r.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")},{timeout:6e4,skipReason:"Fails in docker"}),(0,t.t6)("error",async()=>{const n=new le;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,ae.GD)(t,t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,i]=(0,ce.AP)(e);n.error(t,void 0,i)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")},{skipReason:"Fails in docker"})});const ue="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",he="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",de="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var me;(0,t.L1)("SeqHandler",()=>{let n;async function i(t){const i=e.DataFrame.fromCsv(t);await l.data.detectSemanticTypes(i);const o=n.getSeqHandler(i.getCol("seq"));return[i,o]}(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("Seq-Fasta",async()=>{const[e,n]=await i(ue);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)}),(0,t.t6)("Seq-Fasta-MSA",async()=>{const[e,n]=await i(he);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)}),(0,t.t6)("Seq-Fasta-units",async()=>{const[e,n]=await i(ue);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)}),(0,t.t6)("Seq-Fasta-MSA-units",async()=>{const[e,n]=await i(he);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)}),(0,t.t6)("Seq-Helm",async()=>{const[e,n]=await i("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(n.notation,c.Hi.HELM),(0,t.E3)(n.isHelm(),!0)}),(0,t.t6)("Seq-UN",async()=>{const[e,n]=await i(de);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)}),(0,t.t6)("Seq-UN-auto",async()=>{const[e,n]=await i(de);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)}),(0,t.t6)("column-version",async()=>{const i=e.DataFrame.fromCsv(ue);await 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n;(0,t.gM)(async()=>{n=await(0,u.Q)()}),Q.b9[c.Hi.FASTA],Q.b9[c.Hi.HELM];const 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s=n.getSeqHandler(i).getRegion(r.startIdx,r.endIdx,"regSeq"),a=e.DataFrame.fromCsv(r.tgtCsv).getCol("seq");(0,t.E3)(i.meta.units,r.units),(0,t.E3)(s.meta.units,r.units),(0,t.E3)(i.getTag(c.gp.alphabet),r.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),r.alphabet),(0,t.J6)(s.toList(),a.toList())}),r.positionNames&&(0,t.t6)(`${o}-positionNames`,async()=>{const n=e.DataFrame.fromCsv(r.srcCsv).getCol("seq");r.positionNames.tag&&n.setTag(c.gp.positionNames,r.positionNames.tag);const i=await l.functions.call("Bio:detectMacromolecule",{col:n});i&&(n.semType=i);const o=await l.functions.call("Bio:getRegion",{sequence:n,start:r.positionNames.start,end:r.positionNames.end}),s=e.DataFrame.fromCsv(r.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,r.units),(0,t.E3)(o.meta.units,r.units),(0,t.E3)(n.getTag(c.gp.alphabet),r.alphabet),(0,t.E3)(o.getTag(c.gp.alphabet),r.alphabet),(0,t.J6)(o.toList(),s.toList())})}),(0,t.L1)("SeqHandler: getHelm",()=>{let n,i,o;(0,t.gM)(async()=>{n=await(0,u.Q)(),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)});const r={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(r))(0,t.t6)(e,async()=>{await s(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)});async function s(i,o,r,s){const a=e.Column.fromStrings("seq",[i]),c=e.DataFrame.fromColumns([a]);await l.data.detectSemanticTypes(c);const u=n.getSeqHandler(a),h=(await u.getValue(0)).helm;(0,t.E3)(h,s)}});var pe=n(2582);(0,t.L1)("helm",()=>{const e={"single-linear":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T.[meI]}$$$$"},tgt:{simplePolymers:[6],connections:[],bondedRGroups:[1,2,2,2,2,1]}},"single-cyclized-C-2-2":{src:{helm:"PEPTIDE1{R.F.C.Y.G.H.[GGaz].C.T.[meI]}$PEPTIDE1,PEPTIDE1,3:R3-8:R3$$$"},tgt:{simplePolymers:[10],connections:[[["PEPTIDE1",3,"R3"],["PEPTIDE1",8,"R3"]]],bondedRGroups:[1,2,3,2,2,2,2,3,2,1]}},"single-cyclized-C-1-1":{src:{helm:"PEPTIDE1{F.C.Y.G.H.[GGaz].C.[meI]}$PEPTIDE1,PEPTIDE1,2:R3-7:R3$$$"},tgt:{simplePolymers:[8],connections:[[["PEPTIDE1",2,"R3"],["PEPTIDE1",7,"R3"]]],bondedRGroups:[1,3,2,2,2,1,3,1]}},"single-cyclized-C-0-0":{src:{helm:"PEPTIDE1{C.Y.G.H.[GGaz].C}$PEPTIDE1,PEPTIDE1,1:R3-6:R3$$$"},tgt:{simplePolymers:[6],connections:[[["PEPTIDE1",1,"R3"],["PEPTIDE1",6,"R3"]]],bondedRGroups:[2,2,2,2,2,2]}},"two-separated-5-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$$$$"},tgt:{simplePolymers:[5,1],connections:[],bondedRGroups:[1,2,2,2,1,0]}},"two-separated-1-5":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.Y.[GGaz].T}$$$$"},tgt:{simplePolymers:[1,5],connections:[],bondedRGroups:[0,1,2,2,2,1]}},"two-separated-4-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$$$$"},tgt:{simplePolymers:[4,2],connections:[],bondedRGroups:[1,2,2,1,1,1]}},"two-connected-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$PEPTIDE1,PEPTIDE2,5:R2-1:R1$$$"},tgt:{simplePolymers:[5,1],connections:[[["PEPTIDE1",5,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-connected-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$PEPTIDE1,PEPTIDE2,4:R2-1:R1$$$"},tgt:{simplePolymers:[4,2],connections:[[["PEPTIDE1",4,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-cyclized-1-9":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.[GGaz].T.G.H.F.Y.P}$PEPTIDE2,PEPTIDE2,3:R3-9:R2|PEPTIDE2,PEPTIDE1,3:R4-1:R1$$$V2.0"},tgt:{simplePolymers:[1,9],connections:[[["PEPTIDE2",3,"R3"],["PEPTIDE2",9,"R2"]],[["PEPTIDE2",3,"R4"],["PEPTIDE1",1,"R1"]]],bondedRGroups:[1,1,2,4,2,2,2,2,2,1]}}};for(const[n,{src:i,tgt:o}]of Object.entries(e))(0,t.t6)(n,async()=>{const e=new pe.f(i.helm),n=e.simplePolymers.map(e=>e.monomers.length),r=n.reduce((e,t)=>e+t,0);(0,t.J6)(n,o.simplePolymers);const s=e.connectionList.getConnectionData().map(e=>[[e[0].polymerId,e[0].bond.monomerIdx+1,`R${e[0].bond.rGroupId}`],[e[1].polymerId,e[1].bond.monomerIdx+1,`R${e[1].bond.rGroupId}`]]);(0,t.J6)(s,o.connections);const a=I().count(0).take(e.bondedRGroupsMap.length).map(t=>e.bondedRGroupsMap[t].length).toArray();(0,t.E3)(r,a.length)})});var ge=n(6077),fe=n(6717);const ye=new e.FileSource("System:AppData/Bio"),be={symbol:"allyl_mon",name:"monomer with Allyl R group",molfile:"\n RDKit 2D\n\n 9 8 0 0 0 0 0 0 0 0999 V2000\n 1.4434 -2.1667 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4434 -0.6667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1443 0.0833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1547 -0.6667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.4537 0.0833 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n -3.7528 -0.6667 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1443 1.5833 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4434 2.3333 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 2.7424 0.0833 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 2 0\n 2 3 1 0\n 3 4 1 6\n 4 5 1 0\n 5 6 1 0\n 3 7 1 0\n 7 8 1 0\n 2 9 1 0\nM RGP 3 6 3 8 1 9 2\nM END\n",smiles:"O=C([C@H](CS[*:3])N[*:1])[*:2]",polymerType:"PEPTIDE",monomerType:"Backbone",naturalAnalog:"C",id:16,rgroups:[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[H][*:1]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-Allyl",capGroupName:"Allyl",capGroupSmiles:"C=C[*:3]",label:"R3"}],author:"Admin",createDate:"2026-02-18T14:48:41.723Z",meta:{}},we={symbol:"SomeComplex",name:"Some complex monomer with complex R group",molfile:"\n RDKit 2D\n\n 10 9 0 0 0 0 0 0 0 0999 V2000\n -1.4289 -0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7280 0.3750 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n -4.0270 -0.3750 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n -0.1299 0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.1299 1.8750 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 2.6250 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 -0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 -1.8750 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.4682 -2.6250 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 2.4682 0.3750 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0\n 2 3 1 0\n 4 1 1 6\n 4 5 1 0\n 5 6 1 0\n 4 7 1 0\n 7 8 1 0\n 8 9 1 0\n 7 10 1 0\nM RGP 4 3 3 6 1 9 4 10 2\nM END\n",smiles:"[*:4]OC([C@H](CS[*:3])N[*:1])[*:2]",polymerType:"PEPTIDE",monomerType:"Backbone",naturalAnalog:"C",id:16,rgroups:[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[H][*:1]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-Something",capGroupName:"Something",capGroupSmiles:"C=CC([*:3])=C",label:"R3"},{alternateId:"R4-SomethingElse",capGroupName:"SomethingElse",capGroupSmiles:"ClCCCC=CC([*:4])=CCC",label:"R4"}],author:"Admin",createDate:"2026-02-18T14:48:41.723Z",meta:{}},ve={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},Ce="molfile(sequence)";function Te(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map(e=>e.trimEnd()).join("\n")}(0,t.L1)("toAtomicLevel",async()=>{const n={},i={};let o,r,s,a,h,d;async function m(e,n){const i=e.getCol("sequence");await l.functions.call("Bio:toAtomicLevel",{table:e,seqCol:i,nonlinear:!1});const o=e.getCol(Ce),r=n.getCol(Ce),s=I()(o.values()).map(e=>Te(e)).toArray(),a=I()(r.values()).map(e=>Te(e)).toArray();(0,t.J6)(s,a)}(0,t.gM)(async()=>{h=await(0,fe.j)(),s=await(0,u.Q)(),o=await(0,_.pj)(),r=await(0,D.u)(),await o.loadMonomerLibForTests(),a=o.getMonomerLib();for(const[t,o]of Object.entries(ve))o.inPath,n[t]=e.DataFrame.fromCsv((await ye.readAsText(o.inPath)).replace(/\n$/,"")),n[t].name=o.inPath.split("/").pop(),await l.data.detectSemanticTypes(n[t]),i[t]=e.DataFrame.fromCsv((await ye.readAsText(o.outPath)).replace(/\n$/,""))}),(0,t.Pl)(async()=>{await(0,D.E)(r),await o.loadMonomerLib(!0)});for(const[e,o]of Object.entries(ve))(0,t.t6)(`${e}`,async()=>{await m(n[e],i[e])});!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(d||(d={}));const p={[d.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[d.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[d.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[d.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[d.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[d.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[d.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[d.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[d.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function g(t){const n=p[t],i=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await l.data.detectSemanticTypes(i),i}async function f(e,n){let i=null;const r=o.getMonomerLib();r._monomers.PEPTIDE[be.symbol]=be,r._monomers.PEPTIDE[we.symbol]=we;try{const i=await s.getHelmToMolfileConverter(r),o=s.helmToAtomicLevelSingle(e,i,!0,!0),a=l.chem.convert(o.molfile,l.chem.Notation.Unknown,l.chem.Notation.Smiles);(0,t.E3)(a,n)}catch(e){i=e}if(delete r._monomers.PEPTIDE[be.symbol],delete r._monomers.PEPTIDE[we.symbol],i)throw i}async function y(e,t="seq",n){const i=e.getCol(t),o=await(0,ge.C4)(e,i,a,s,h);return o.warnings.length>0&&Re.logger.warning(`_toAtomicLevel() warnings ${o.warnings.join("\n")}`),o.molCol}(0,t.t6)("fastaDna",async()=>{await y(await g(d.fastaDna),"seq")}),(0,t.t6)("fastaRna",async()=>{await y(await g(d.fastaRna),"seq")}),(0,t.t6)("fastaPt",async()=>{await y(await g(d.fastaPt),"seq")}),(0,t.t6)("fastaUn",async()=>{await y(await 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n.loadMonomerLibForTests(),r=n.getMonomerLib()}),(0,t.Pl)(async()=>{await(0,D.E)(i),await n.loadMonomerLib(!0)});const a={fasta:{src:{seq:"MDYKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},"fasta-with-gap":{src:{seq:"MD-YKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},helm:{src:{seq:"PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}},"helm-with-gap":{src:{seq:"PEPTIDE1{meI.hHis.*.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}}},h=async t=>{const n=t.src.seq,i=e.DataFrame.fromColumns([e.Column.fromList(e.COLUMN_TYPE.STRING,"seq",[n])]);return await l.data.detectSemanticTypes(i),i.getCol("seq")};for(const[e,n]of Object.entries(a))(0,t.t6)(`${e}-linear`,async()=>{const e=await h(n);await d(e,!1,n.tgt)});if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length)for(const[e,n]of Object.entries(a))(0,t.t6)(`${e}-nonlinear`,async()=>{const e=await h(n);await d(e,!0,n.tgt)});async function 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e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});Me(r,s,e,.2)}),(0,t.t6)("needleman-custom-del",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});Me(a,l,e,.667)}),(0,t.t6)("needleman-custom-zero-extend",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:0});Me(c,h,e,.333)}),(0,t.t6)("needleman-custom-half-extend",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:2,gapExtend:1});Me(c,h,e,1.667)}),(0,t.t6)("needleman-custom-same-extend",async()=>{const t=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?Me(Array(1e3).fill(c).join(""),Array(1e3).fill(h).join(""),t,1.333):Me(c,h,t,1.333)},{benchmark:!0})});var xe=n(684);async function Pe(n,i,o,r,s,a,c,u){await l.data.detectSemanticTypes(n),await l.functions.call("Bio:activityCliffs",{table:n,molecules:n.getCol(o),activities:n.getCol(r),similarity:s,methodName:i,similarityMetric:c,preprocessingFunction:u,options:{[`${xe.vb}`]:!0},demo:!1});const h=Array.from(l.shell.tv.viewers)[1];(0,t.E3)(h?.type===e.VIEWER.SCATTER_PLOT,!0),await(0,t.bk)(()=>{const e=Array.from(h.root.getElementsByClassName("scatter_plot_link"));return!e.length||e[0].innerText.toLowerCase()===`${a} cliffs`},"incorrect cliffs link",3e3)}var Ie=n(2780),Le=n(9039),_e=n(9124);async function Ne(n,i,o){const r=n.getCol(o);n.name="seqSpaceDf";const s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!a)throw new Error("Preprocessing function not found");await l.functions.call("Bio:sequenceSpaceTopMenu",{table:n,molecules:n.col(o),methodName:i,similarityMetric:Ee.Z.LEVENSHTEIN,plotEmbeddings:!0,preprocessingFunction:a,options:{[xe.vb]:!0}});const c=l.shell.tableView(n.name),u=Array.from(c?.viewers??[])[1];(0,t.E3)(null!=u)}(0,t.L1)("activityCliffs",async()=>{let n,i,o;const r=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],s=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)(async()=>{e.Func.find({package:"Helm",name:"getHelmHelper"}).length&&(n=await(0,_e.b2)()),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)}),(0,t.t6)("activityCliffsOpens",async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_with_random_motif_1600.csv",tgt:{cliffCount:64}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await $(t.fileName);l.shell.addTableView(n),await Pe(n,Le.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,Ee.Z.LEVENSHTEIN,r)},{benchmark:!0,skipReason:"Fails"}),(0,t.t6)("activityCliffsWithEmptyRows",async()=>{const e=await $("tests/100_3_clustests_empty_vals.csv");l.shell.addTableView(e),await Pe(e,Le.c.UMAP,"sequence","Activity",90,3,Ee.Z.LEVENSHTEIN,r)}),(0,t.t6)("Helm",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await Re.files.readCsv("samples/HELM_50.csv");l.shell.addTableView(e),await Pe(e,Le.c.UMAP,"HELM","Activity",65,20,Ie.aT.Tanimoto,s)}})}),(0,t.L1)("sequenceSpace",async()=>{let n,i,o,r;(0,t.t6)("sequenceSpaceOpens",async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_with_random_motif_1600.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await $(t.fileName),i=l.shell.addTableView(n),await Ne(n,Le.c.UMAP,"sequence")},{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",async()=>{o=await $("tests/100_3_clustests_empty_vals.csv"),r=l.shell.addTableView(o),await Ne(o,Le.c.UMAP,"sequence")})}),(0,t.L1)("Scoring",()=>{const n="sequence",i="expected_similarity",o="expected_identity",r=e.DataFrame.fromCsv(`${n},${i},${o}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.691,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.37,0.0`),s=r.getCol(n);s.meta.units=c.Hi.HELM,s.semType=e.SEMTYPE.MACROMOLECULE;const a=s.get(0);let u,h;(0,t.gM)(async()=>{u=await(0,_.pj)(),h=await(0,D.u)(),await u.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(h),await u.loadMonomerLib(!0)}),(0,t.t6)("Identity",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:a});for(let n=0;n<e.length;n++){const i=e.get(n),s=r.get(o,n);(0,t.Wj)(i,s,.01,`Wrong identity score for sequence at position ${n}`)}}),(0,t.t6)("Identity-shortReference",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$"});(0,t.E3)(I().count(0).take(e.length).map(t=>e.get(t)).every(e=>null!=e&&!isNaN(e)),!0)}),(0,t.t6)("Identity-longReference",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$"});(0,t.E3)(I().count(0).take(e.length).map(t=>e.get(t)).every(e=>null!=e&&!isNaN(e)),!0)}),(0,t.t6)("Similarity",async()=>{const e=await l.functions.call("Bio:sequenceSimilarityScoring",{table:r,macromolecule:s,reference:a});for(let n=0;n<e.length;n++){const o=e.get(n),s=r.get(i,n);(0,t.Wj)(o,s,.01,`Wrong similarity score for sequence at position ${n}`)}})});const Re=new e.Package;async function $e(n,i,o,r){const 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i=Object.keys(n),o=i.length,r=0;return new _(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),m=i.type;!0!==(r=d.next()).done;){var p=!1;if(s=r.value,"undirected"!==m)for(a in l=s.out){c=l[a];do{if(u=c.target,p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==m)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),p=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!p&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new B('Graph.import: invalid serialized node. 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Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Te={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function Ee(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new U("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new U("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new U("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new U("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. 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Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new U("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,m,p=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new U("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));m=d}if(m||e.multi||!p||(m=i?p.undirected[s]:p.out[s]),m){var f=[m.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=m.attributes;m.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:m.key,attributes:m.attributes})}else a(m.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:m.key,attributes:m.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var w=!1,v=!1;p||(p=Ae(e,r,{}),w=!0,r===s&&(g=p,v=!0)),g||(g=Ae(e,s,{}),v=!0),d=new j(i,o,p,g,l),e._edges.set(o,d);var C=r===s;return i?(p.undirectedDegree++,g.undirectedDegree++,C&&(p.undirectedLoops++,e._undirectedSelfLoopCount++)):(p.outDegree++,g.inDegree++,C&&(p.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,w,v]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var xe=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Te,e)).multi)throw new B("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new B('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new B("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?W:"directed"===e.type?q:Y;h(s(t),"NodeDataClass",i);var o="geid_"+we()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new B("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new U("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new B('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new U('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new B('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new B('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new B("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new B("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new B("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new B("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!m(t))throw new B("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!m(t))throw new B("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new B("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new B("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new B("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new B("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new B("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new B("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new B("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new B("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new _(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new B("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new B("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new B("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var m=!1;if("undirected"===this.type&&(m=!0),o=e.edges,!Array.isArray(o))throw new B("Graph.import: invalid edges. 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l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let m=0;const p=(a+1)/n;for(let e=0;e<o;e++)r[e]<p&&(l[m]=h[e],c[m]=d[e],u[m]=r[e],m++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const m=await Promise.all(h),p=m.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(p),f=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(m[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),m=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*m,p=t===this._workerCount-1?h:(t+1)*m;p<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,p)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const p=await Promise.all(u),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of p)for(let t=0;t<(e.knnDistances?.length??0);++t)H(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)H(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,m=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),m=d.reduce((e,t)=>e+t.distance.length,0),p=new Float32Array(m);let g=0;for(const e of d)p.set(e.distance,g),g+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=O(e[l])||O(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var F,G=n(8774);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(F||(F={}));class B{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=F.none){var r;this._currentLineIdx=-1,this.lineClicked=new c.Subject,this.lineHover=new c.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new G.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,m,p,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,w=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let v=null==b?void 0:b.x,C=null==b?void 0:b.y;const T=this.sp.pointToScreen(this.lines.to[e]);let A=null==T?void 0:T.x,E=null==T?void 0:T.y;const S=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),v&&C&&A&&E&&Math.hypot(A-v,E-C)/S>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let T=null;if(b){t=this.getLineLength(v,C,A,E);const o=this.getPointOnDistance(v,C,A,E,i,t),r=this.getPointOnDistance(A,E,v,C,n,t);v=o.x,C=o.y,A=r.x,E=r.y,T=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,v,C,A,E,e):this.findControlPoint(b,A,E,v,C,e),this.ctx.moveTo(v,C),this.ctx.quadraticCurveTo(T.x,T.y,A,E)}else(!this.lines.skipShortLines||Math.pow(A-v,2)+Math.pow(E-C,2)>w)&&(this.ctx.moveTo(v,C),this.ctx.lineTo(A,E));if((null!==(m=this.lines.drawArrows)&&void 0!==m?m:null===(p=this.lines.drawArrowsArr)||void 0===p?void 0:p.getBit(e))&&(t||(t=this.getLineLength(v,C,A,E)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(v,C,A,E,i,t),n=b?T.x:v,o=b?T.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:v,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case F.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case F.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new G.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,m=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,p=Math.abs(e-a),g=Math.abs(t-m),f=p+g;(!d||d>f)&&(d=f),h[r]=Math.max(p,g),c[r]=a,u[r]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!p||p>i)&&(p=i)}return p}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const a=n-o*((n-e)/r),l=i-o*((i-t)/r);return new s.Point(a,l)}findControlPoint(e,t,n,i,o,r){const a=t+(i-t)/2,l=n+(o-n)/2;let c=a-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new s.Point(a+d/2*u,l-d/2*c):new s.Point(a-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const V="dimensionality-reducer-terminate-event";var U,W=n(3629);async function q(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(V).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,r,s,a,l);return c=c.map(e=>(0,W.S8)(e)),c}!function(e){e.EUCLIDEAN="EUCLIDEAN",e.MANHATTAN="MANHATTAN"}(U||(U={}));const Y={[U.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[U.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var j;!function(e){e.HAMMING="Hamming",e.EUCLIDEAN="Euclidean",e.VECTOR_COSINE="Vector Cosine",e.MANHATTAN="Manhattan",e.TANIMOTO="Tanimoto",e.LEVENSTEIN="Levenshtein",e.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",e.SOKAL="Sokal",e.COSINE="Cosine",e.ASYMMETRIC="Asymmetric",e.Difference="Difference",e.OneHot="One-Hot"}(j||(j={}));const K={[j.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[j.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[j.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[j.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[j.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[j.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[j.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[j.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[j.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[j.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[j.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[j.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[j.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},z={[j.HAMMING]:e=>Math.ceil(e/30),[j.EUCLIDEAN]:e=>Math.ceil(e/30),[j.MANHATTAN]:e=>Math.ceil(e/30),[j.TANIMOTO]:e=>Math.ceil(e/30),[j.SOKAL]:e=>Math.ceil(e/30),[j.COSINE]:e=>Math.ceil(e/30),[j.ASYMMETRIC]:e=>Math.ceil(e/30),[j.LEVENSTEIN]:e=>Math.ceil(e*e/60),[j.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[j.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[j.Difference]:e=>1,[j.OneHot]:e=>Math.ceil(e/40),[j.VECTOR_COSINE]:e=>Math.ceil(e/30)},Z={STRING:new Set([j.HAMMING,j.LEVENSTEIN,j.NEEDLEMAN_WUNSCH,j.MONOMER_CHEMICAL_DISTANCE,j.OneHot]),UINT32ARRAY:new Set([j.HAMMING,j.EUCLIDEAN,j.MANHATTAN,j.MONOMER_CHEMICAL_DISTANCE,j.LEVENSTEIN,j.NEEDLEMAN_WUNSCH,j.TANIMOTO,j.COSINE,j.VECTOR_COSINE,j.SOKAL,j.ASYMMETRIC,j.OneHot,j.Difference]),INT32ARRAY:new Set([j.EUCLIDEAN,j.MANHATTAN,j.OneHot,j.Difference,j.VECTOR_COSINE]),FLOAT32ARRAY:new Set([j.EUCLIDEAN,j.MANHATTAN,j.Difference,j.VECTOR_COSINE]),NUMBER:new Set([j.EUCLIDEAN,j.MANHATTAN,j.Difference]),BITARRAY:new Set([j.TANIMOTO,j.COSINE,j.SOKAL,j.ASYMMETRIC])};function X(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return E(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!S&&(S=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==S))return null;let e=!1;if(M&&(M.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!M||e){const e=1e9,t=S.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield S.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield S.requestDevice(),M}}return M})}();if(!s)return null;const a=Object.values(j);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(U).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map((e,t)=>function(e,t=j.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!Z[s]||!Z[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=z[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach((e,t)=>{m.set(e,t*u)});let p="",g=0,f="FLOAT32ARRAY",y=null;if(t===j.NEEDLEMAN_WUNSCH||t===j.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===j.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=m.reduce((e,t)=>Math.min(e,t),m[0]),t=m.reduce((e,t)=>Math.max(e,t),m[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",w=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:p,entryType:s,dataTypeWGSL:b,dataStructWgsl:w,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*u);h.forEach((e,t)=>{g.set(e.arraySizes,t*u)});const f=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),w=Math.ceil(6e3/b),v=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*v,T=u*(u-1)/2,A=Math.ceil(T/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${A} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${w}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${Q(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n `}),P=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),_=new Uint32Array(f),N=new Uint32Array(f),R=Math.floor(T/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?T-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,_[e]=i,N[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const H=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),D=h.reduce((e,t)=>e+t.suppInfoSize,0),k=1e6,F=H*Uint32Array.BYTES_PER_ELEMENT;let G=F;const B=15&F;0!==B&&(G+=16-B);const V=s.createBuffer({label:"compute info buffer",size:G,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let q=0;new Uint32Array(W,q,f).set(I),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(L),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(_),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f).set(N),q+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g.length).set(g),q+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,q,c).set(o),q+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,q,n).set(e.flatSourceArray),q+=n*t.BYTES_PER_ELEMENT}V.unmap();const Y=D*Uint32Array.BYTES_PER_ELEMENT;let K=Y;const X=15&Y;0!==X&&(K+=16-X),K=Math.max(K,16);const J=s.createBuffer({label:"supp info buffer",size:K,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=J.getMappedRange();let te=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),J.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=ne;const oe=15&ne;0!==oe&&(ie+=16-oe);const re=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:P.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:J}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(P),t.setBindGroup(0,se),t.dispatchWorkgroups(v,v),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,k);o+=k*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,k);o+=k*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,k);o+=k*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),me=new Uint32Array(de),pe=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)me.set(le[e],fe),pe.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),J.destroy(),re.destroy(),ae.destroy(),{i:me,j:pe,distance:ge}})}function Q(e,t,n,i){return e.map((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${K[e](t[i],i)}\n }\n `).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n ${Y[i](e.length)}\n }\n \n `}var J=n(1991),ee=n.n(J);let te=0;const ne="cliffsDf",ie=new c.Subject,oe="SALI",re="line index",se=["From","To"],ae="filterCliffs";async function le(e,t,i,a,l,c,u,h,d,m,p,g,f,y,b,w,v){te++;const C=c/100;let T,A=!1;const E=g.inputs,S=await g.apply({[E[0].name]:t,[E[1].name]:u,...d.preprocessingFuncArgs??{}});let M=[];if(h===L){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([S.entries],c,[1],"MANHATTAN",[u],[S.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),M=[t.embedX,t.embedY]}else M=await q([S.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[S.options??{}]});if(M.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<M.length;++t)e.columns.addNewFloat(i[t]).init(e=>M[t][e]);let x=null;if(d.useWebGPU)try{x=await X([S.entries],C,[u],U.MANHATTAN,[1],[S.options??{}])}catch(e){console.error(e)}x||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),x=await(new k).calc(S.entries,u,C,S.options));const P=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,a=s.BitSet.create(t.length);return e.distance.forEach((t,n)=>{a.set(e.i[n],!0),a.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:a}}(x,l),I=function(e,t,n,i,o,r,a){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(a.get(i[e])>a.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return s.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);e.columns.add(I);const _=P.cliffsBitSet,N=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(P.saliVals),$=.8/(N.max-N.min),O=o.shell.tv?.dataFrame===e?o.shell.tv:o.shell.getTableView(e.name),H=O.addViewer(s.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:a}),D=function(e,t,n,i,o,r,a,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-a.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=s.DataFrame.create(c.from.length);return se.forEach((e,t)=>{u.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(u.col(e),r),u.col(e).semType=o}),u.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),u.columns.addNewInt(re).init(e=>e),u.columns.addNewFloat(oe).init(e=>t.saliVals[e]),u.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),u.name=`${ne}${te}`,{lines:c,linesDf:u}}(e,P,t,l,m,p,N,$);D.lines.skipMultiLineCalculation=!0,D.linesDf.col(oe).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const G=new B(H,i[0],i[1],D.lines,F.none),V=b?b(D.linesDf,se).sort([oe],[!1]):D.linesDf.plot.grid().sort([oe],[!1]);V.col(re)&&(V.col(re).visible=!1),e.temp[".cliffsDfGrid"]=V;const W=r.button(`${D.linesDf.rowCount} cliffs`,()=>{const e=ee()(O.viewers).some(e=>e.dataFrame.name===`${ne}${te}`);v&&!e&&O.addViewer(V),O.dockManager.dock(V,"down",null,"Activity 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n=D.linesDf.currentRowIdx;G.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<o?n:o)+s/2-h/2,p=(i>r?i:r)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],D.lines.from[n]),H.dataFrame.get(i[1],D.lines.from[n]),H.dataFrame.get(i[0],D.lines.to[n]),H.dataFrame.get(i[1],D.lines.to[n]));H.zoom(a,u,c,h),Y.value?e.filter.and(_):!0===Y.enabled&&e.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,s,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:s,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout(()=>{o.shell.o=t.root},500)}(e,T,D.lines.from[s],D.lines.to[s],s,t,l,D.linesDf.get(oe,s),y);const n=H.dataFrame.getSortedOrder(O.grid.sortByColumns,O.grid.sortTypes);O.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))},1e3)}}),D.linesDf.onSelectionChanged.subscribe(t=>{setTimeout(()=>(()=>{const t=s.BitSet.create(e.rowCount);for(let e=0;e<D.linesDf.rowCount;e++){const n=D.linesDf.selection.get(e);n&&(t.set(D.lines.from[e],!0),t.set(D.lines.to[e],!0)),D.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),G.linesToRender=D.lines})(),100)}),e.onSelectionChanged.subscribe(t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<D.lines.colors.length;e++)D.lines.colors[e]="0,128,0";G.linesToRender=D.lines})(V.dataFrame))}),G.lineClicked.subscribe(t=>{if(A=!0,G.currentLineId=t.id,-1!==t.id){const n=D.linesDf.selection.clone();setTimeout(()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),D.linesDf.selection.copyFrom(n)):(D.linesDf.currentRowIdx!==t.id&&(D.linesDf.currentRowIdx=t.id,e.currentRowIdx=D.lines.from[t.id]),D.linesDf.selection.copyFrom(n));const i=D.linesDf.getSortedOrder(V.sortByColumns,V.sortTypes);V.scrollToCell(se[0],i.indexOf(t.id))},500)}}),G.lineHover.pipe((0,R.debounceTime)(500)).subscribe(n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&r.tooltip.show(f({lineId:n.id,points:[D.lines.from[n.id],D.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)}),H.addProperty("similarityLimit","double",C),T=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",()=>r.divText("Cliff has not been selected"),!0),o.shell.o=e.root,e}(),H}var ce=n(6863),ue=n(2003),he=n(3516),de=n(3151);function me(e,t){const n=e=>o[e]??null,i=e=>{const t=a.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,a=s.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getCanonical(o);(n(o)||i(o)).set(e,r,!1)}}return a}var pe,ge=n(439),fe=n(4971);async function ye(e){const t=(await(0,fe.pj)()).getMonomerLib(),n=[],i={},r=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),a=s.Column.fromStrings("smiles",r);for(let t=0;t<r.length;++t){i[e[t]]=t;const s=r[t],l=""===s?new Array(r.length).fill(0):(await o.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var be=n(9192);class we{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class ve extends N{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[L]=new we}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ce,Te,Ae;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Se(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Me(e,t,i,l,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},g={},f=null,y={},b){const w={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==l.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?g.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=s.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let T;try{const A=Ee(e);function E(n,o,l){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(s.Column.float(A[0],e.rowCount)),u=e.columns.add(s.Column.float(A[1],e.rowCount)),d&&!T&&(T=v.scatterPlot({...w,x:A[0],y:A[1],title:g.scatterPlotName??Se(t,i)}))),g[a.YP]&&(T?.root&&r.setUpdateIndicator(T.root,!1),c.init(e=>l[0]?l[0][e]:void 0),u.init(e=>l[1]?l[1][e]:void 0));const h=n/o*100;C.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function S(){e.columns.add(s.Column.float(A[0],e.rowCount)),e.columns.add(s.Column.float(A[1],e.rowCount));let n=null;d&&(T=v.scatterPlot({...w,x:A[0],y:A[1],title:g.scatterPlotName??Se(t,i)}),r.setUpdateIndicator(T.root,!0));const m=o.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&T?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===T?.getOptions()?.look?.title&&(o.events.fireCustomEvent(V,{}),m.unsubscribe(),n?.(),C.close())}),f=new Promise(async(o,r)=>{try{n=o;const r=[];let s=l,d=c,m=h;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];p.distanceFnArgs=[{}],r.push({entries:i,options:{}}),s=[b],d=[1],m="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:s,options:a}=await n.apply({[i]:t[e],[o]:l[e],...p.preprocessingFuncArgs[e]??{}});r.push({entries:s,options:a}),p.distanceFnArgs.push(a)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),p.distanceFnArgs.push(i)}}o(await q(r.map(e=>e.entries),i,s,d,h,p,g[a.vb]?void 0:E))}catch(e){r(e)}}),y=await f;return C.close(),m.unsubscribe(),y}const M=await S();if(m&&M){const x=s.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const P=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>P[e].toString()),T&&(T.props.colorColumnName=I)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{x.close()}}if(M){const _=e.columns.byName(A[0]),N=e.columns.byName(A[1]);if(_.init(e=>M[0][e]),N.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:_,[$]:N,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(T)return r.setUpdateIndicator(T.root,!1),T.helpUrl="/help/compute/sequence-space",T}}catch(H){o.shell.error("Dimensionality reduction failed"),console.error(H),C.close(),T&&r.setUpdateIndicator(T.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[a.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ce||(Ce={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Te||(Te={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Ae||(Ae={})),Object.prototype.toString;var xe=n(6873),Pe=n(4356),Ie=n(6717),Le=n(4025),_e=n(4870),Ne=n(3856),Re=n(6882),$e=n(7278),Oe=n(5553),He=n(6642),De=n(3599),ke=n(673),Fe=n(8312);class Ge extends He.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,To.logger),(0,fe.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,Fe.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Be=n(4139);const Ve=ue.zS;function Ue(e){const t=!ee().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of ee().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class We extends s.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=To.seqHelper}getRendererBack(e){const[t,n,i]=(0,He.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Oe.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,He.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(To.properties?To.properties.maxMonomerLength:4)??50;if(Ne.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Ne.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let m=c.rendererBack;m||(m=c.rendererBack=new Re.Jy(a,l,To.logger,d,()=>{const{font:e,fontWidth:t}=Re.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:Ve}}),l.temp[".mm.cellRenderer.settingsChanged"],ke.s.true,m.init().then(()=>{})),m.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class qe extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[ue.gp.separator],h=this.tableCol.meta.units;i=(0,Re.U0)(l,e,t,i,a);const[d,m]=c.split("#"),p=this.tableCol.temp[Le.j.notationProvider]?.separatorSplitter??(0,$e.Iv)(h,u),g=p(d),f=p(m),y=ee().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=ee().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),w=this.tableCol.getTag(ue.gp.alphabet);je(e,t,n,i,o,y,b,w===ue.YI.RNA||w===ue.YI.DNA?De.o.NUCLEOTIDE:De.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new qe(t,n)),o}}class Ye extends s.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Be.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){qe.getOrCreate(r).render(e,t,n,i,o,r,s)}}function je(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ge.b9[ue.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ee()(t).toArray()):e=l(ee()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(Ue(r).join("")),d=e.measureText(Ue(s).join("")),m=Math.max(h.width,d.width);c&&(i=m+4*r.length,e.canvas.width=m+4*r.length);let p=Math.max(t,t+(i-(m+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?m+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Re.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Re.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Ne.oZ)(e,n,p,g-h,i,o,{color:d,pivot:0,left:!0}),m=(0,Ne.oZ)(e,c,p,g+h,i,o,{color:r,pivot:0,left:!0});p=Math.max(m,s),u&&(u[t]=Ke(n,c,d,r,g,h,o))}else p=(0,Ne.oZ)(e,n,p,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});p+=4}}finally{e.restore()}}function Ke(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ue([e]).join("")).width,u=l.measureText(Ue([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Ne.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,Ne.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var ze,Ze=n(5749),Xe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ze||(ze={}));const Qe=new class{constructor(){this.regionTypes=[ze.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Xe.fH.Entropy,this.filterSource=Xe.Fo.filterSource}};var Je=n(7602),et=n(250);const tt=ze;var nt,it;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(nt||(nt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(it||(it={}));const ot=Qe;class rt extends s.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(it.skipEmptyPositions,ot.skipEmptyPositions,{category:nt.DATA}),this.regionTypes=this.stringList(it.regionTypes,ot.regionTypes,{category:nt.DATA,choices:Object.values(tt).filter(e=>e!=tt.Unknown)}),this.chains=this.stringList(it.chains,ot.chains,{category:nt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(it.fitWidth,ot.fitWidth,{category:nt.LAYOUT}),this.positionWidth=this.float(it.positionWidth,ot.positionWidth,{category:nt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(it.positionHeight,ot.positionHeight,{category:nt.LAYOUT,choices:Object.keys(Xe.fH)}),this.filterSource=this.string(it.filterSource,ot.filterSource,{category:nt.BEHAVIOR,choices:Object.values(Xe.lT)}),this.viewSyncer=new Je.g(To.logger)}static viewerCounter=-1;viewerId=++rt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,c.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case it.regionTypes:case it.chains:this.setData(this.regions)}switch(e.name){case it.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case it.fitWidth:case it.positionWidth:this.calcSize();break;case it.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionHeight]:this.positionHeight});this.calcSize();break;case it.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;To.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){To.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){To.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=r.table(this.chains,e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(Xe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),To.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){To.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[et.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[et.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(it.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[et.n5.filterSource]:this.filterSource})}}})}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Ze.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class st{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class at{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new at(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new st);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ct(e,t,n="Morgan",i=1,o=.6){const r=e.length,a=To.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=a.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let m={};if(t===ce.Z.MONOMER_CHEMICAL_DISTANCE||t===ce.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,fe.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),a=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!a)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await ye(e);const l=s.Column.fromStrings("smiles",r),c=(s.DataFrame.fromColumns([l]),(await a.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await ye(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,$.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),a={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{a[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);m={scoringMatrix:r.scoringMatrix,alphabetIndexes:a,maxLength:c},t===ce.Z.NEEDLEMANN_WUNSCH&&(m.gapOpen=i,m.gapExtend=o)}return{seqList:l,options:m}}var ut=n(4954);function ht(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))}),t}function dt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=To.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=pt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function pt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=To.monomerLib;return je(r,0,0,0,30,ee().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),ee().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function gt(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function ft(e,t){const n=s.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ue.gp.separator,e.col(t[0]).getTag(ue.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class yt extends s.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(s.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(s.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(s.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(s.debounce(r.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class bt extends yt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ce.Z.NEEDLEMANN_WUNSCH,ce.Z.HAMMING,ce.Z.LEVENSHTEIN,ce.Z.MONOMER_CHEMICAL_DISTANCE];tags=[s.TAGS.UNITS,ue.gp.aligned,ue.gp.separator,ue.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",ce.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ce.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ce.Z.NEEDLEMANN_WUNSCH}}const wt={gapPenalty:1,matchScore:1,gapSymbol:ge.b9[ge.Hi.FASTA],localAlignment:!1};class vt extends bt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new c.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==(this.dataFrame?.currentRowIdx??-1)?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame?.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=s.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=s.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t?.currentRowIdx??-1)<0||(this.dataFrame&&(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx)),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,_e.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,_e.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ct(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new k).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:s.FLOAT_NULL}),this.idxs=s.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=s.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,s=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(s),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...wt,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),m=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(m.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),m.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),m.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...ee().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?ee().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],m=[...ee().count(0).take(h).map(e=>t.getCanonical(e)),...m.reverse(),...i.localAlignment?ee().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const p=u,g=h;return p>g?m=[...new Array(p-g).fill(i.gapSymbol.valueOf()),...m]:d=[...new Array(g-p).fill(i.gapSymbol.valueOf()),...d],m.length>d.length?d.push(...new Array(m.length-d.length).fill(i.gapSymbol.valueOf())):m.push(...new Array(d.length-m.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:m.join(""),seq1Splitted:new $e.Mu(d,i.gapSymbol),seq2Splitted:new $e.Mu(m,i.gapSymbol)}}(c,u),d=pt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const m=r.accordion(),p=r.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(r.span([p,r.label("Similarity search")])),m.addPane("Differences",()=>t,!0),o.shell.o=m.root}}class Ct extends bt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new c.Subject;sampledIndices=null;constructor(e){super("diversity",s.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=s.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=s.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=s.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,_e.Kd)(i,t.name,450,30),(0,_e.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ct(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new D(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Tt,At=n(5433),Et=n(3890),St=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Tt||(Tt={}));class Mt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class xt extends Mt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends xt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(Tt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(Tt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(Tt.TYPE)&&-1!==e.indexOf(Tt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Tt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Tt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Tt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Tt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class It extends xt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Lt{constructor(){}static getInstance(e){if(Lt.isMolfileV2K(e))return new Pt(e);if(Lt.isMolfileV3K(e))return new It(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return It.isValidMolfile(e)}}var _t=n(6197),Nt=n(9124),Rt=n(3527);class $t{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++$t.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ot extends $t{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Ht extends $t{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Dt extends $t{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class kt extends $t{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Ft extends $t{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Gt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Ft(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Gt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Bt={[De.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[De.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[De.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[De.o.CHEM]:{R:"#eeeeee"},[De.o.BLOB]:{B:"#999999",G:"#e2e2e2"}};class Vt{constructor(e,t=[],n={}){this.onItemChanged=new c.Subject,this.onAddingItemChanged=new c.Subject,this.onItemAdded=new c.Subject,this.onItemRemoved=new c.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],a={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),o.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==s.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),a[c.name]=u,u.onChanged.subscribe(()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})}),u.root.style.alignItems="center",l=u}let c=null;if(t)this.addingItemInputs=a,c=r.icons.add(()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(a).forEach(t=>{e[t]=a[t].value}),this._items.push(e),this.onItemAdded.next(e),this.render()},this.options.addButtonTooltip);else{if(!this.options.allowRemove)return o;c=r.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const Ut={A:new G.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new G.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new G.A(new 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new G.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Wt[t])return null;const o=Wt[t];let r=0,a=null;for(const[e,t]of Object.entries(o)){const o=(0,$.$1)(i,t);o>r&&o>=n&&(r=o,a=e)}return a}var Yt=n(857),jt={};jt.styleTagTransform=C(),jt.setAttributes=y(),jt.insert=g().bind(null,"head"),jt.domAPI=m(),jt.insertStyleElement=w(),h()(Yt.A,jt),Yt.A&&Yt.A.locals&&Yt.A.locals;const Kt=[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[*:1][H]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-H",capGroupName:"H",capGroupSmiles:"[*:3][H]",label:"R3"},{alternateId:"R4-H",capGroupName:"H",capGroupSmiles:"[*:4][H]",label:"R4"},{alternateId:"R5-H",capGroupName:"H",capGroupSmiles:"[*:5][H]",label:"R5"},{alternateId:"R6-H",capGroupName:"H",capGroupSmiles:"[*:6][H]",label:"R6"}];function zt(e,t,n){let i=t[e]??n[e];if(i&&i.length>0)return i;const r=dn(e,Kt);if(r!==e){const e=o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles);if(i=t[e]??n[e],i&&i.length>0)return i}return[]}function Zt(e){const t=new Set;return e.filter(e=>!t.has(e.symbol)&&(t.add(e.symbol),!0))}function Xt(e,t){const n=new Set;for(const i of e){const e=t[i.symbol];if(e&&e.length>0)for(const t of e){const e=t?.lib?.source;e&&n.add(e)}else i.source&&n.add(i.source)}return Array.from(n).join(", ")}var Qt;!function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Qt||(Qt={}));const Jt={[Qt.MONOMER]:s.COLUMN_TYPE.STRING,[Qt.SYMBOL]:s.COLUMN_TYPE.STRING,[Qt.NAME]:s.COLUMN_TYPE.STRING,[Qt.R_GROUPS]:s.COLUMN_TYPE.STRING,[Qt.MONOMER_TYPE]:s.COLUMN_TYPE.STRING,[Qt.POLYMER_TYPE]:s.COLUMN_TYPE.STRING,[Qt.NATURAL_ANALOG]:s.COLUMN_TYPE.STRING,[Qt.AUTHOR]:s.COLUMN_TYPE.STRING,[Qt.CREATE_DATE]:s.COLUMN_TYPE.DATE_TIME,[Qt.ID]:s.COLUMN_TYPE.INT,[Qt.META]:s.COLUMN_TYPE.STRING,[Qt.SOURCE]:s.COLUMN_TYPE.STRING};async function en(e){const t=await tn(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>mn(t.rows.get(n))))}async function tn(e){try{const t=s.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Jt))if(t.columns.addNew(e,n),e===Qt.R_GROUPS)for(const e of i)t.columns.addNew(e,s.COLUMN_TYPE.STRING);t.col(Qt.SYMBOL).semType="Monomer",t.col(Qt.SYMBOL).setTag(Ne.Mn.applyToBackground,"true"),t.col(Qt.SYMBOL).setTag(ge.qE.polymerTypeColumnName,Qt.POLYMER_TYPE);const o=s.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=un(e[n].rgroups,e[n].smiles,e[n].molfile);o=on(o),e[n].rgroups=ln(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?sn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(Qt.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(Qt.MONOMER).semType=s.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=s.SEMTYPE.MOLECULE}),t}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}}class nn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Qt.NAME).width=100,this.tv.grid.col(Qt.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=de.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new cn(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(Qt.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await kn.getInstance();await e.awaitLoaded(),this.instance=new nn(e)}return this.instance}static async getNewInstance(){const e=await kn.getInstance();return await e.awaitLoaded(),new nn(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const r=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,r),await this.monomerLibManamger.loadMonomerLib(!1),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const s=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=r.input.choice("Storage",{items:s,value:s[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===s.length&&(a.readOnly=!0);const l=r.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)o.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}l.close()}else o.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=s.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=o.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==s.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>mn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>mn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await mn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter(e=>e.name===nn.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?o.shell.v=e:nn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const a=r.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=r.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=r.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=r.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>mn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await mn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});r.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=r.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{const n=await(0,fe.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);s.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([a,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=nn.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,s.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await mn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,fe.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),s.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await tn(i)}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,fe.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>mn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),o.shell.v=await this.getViewRoot(t)}catch(e){o.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else o.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function on(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const rn=["alternateId","capGroupName","capGroupSMILES","label"];function sn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function an(e,t,n){const i=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());i?e[i]=n:e[t]=n}function ln(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(rn,e),n=sn(t,"capGroupSMILES"),i=sn(t,"alternateId"),o=sn(t,"capGroupName"),r=sn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class cn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new pn(this.colors),this.molSketcher=new s.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=un([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await qt(dn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const a=[s.Property.js("capGroupSMILES",s.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),s.Property.js("alternateId",s.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),s.Property.js("capGroupName",s.TYPE.STRING,{caption:"R-group name",nullable:!1}),s.Property.js("label",s.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new Vt(a,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[s.Property.js("Property",s.TYPE.STRING,{caption:"Property",nullable:!0}),s.Property.js("Value",s.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new Vt(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=ln(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&qt(dn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=un(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,fe.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void o.shell.error(`Library ${t} not found in any provider`);const s=r.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=r.dialog("Remove Monomer"+(a?"s":"")).add(r.h1(l)).add(s).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void o.shell.error("No monomer library loaded");const i=n?.col(Qt.POLYMER_TYPE)?.toList()??[],s=n?.col(Qt.SYMBOL)?.toList()??[],a=n?.col(Qt.MONOMER)?.toList()??[];if(i.length!==s.length||i.length!==a.length)return void o.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&s[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,fe.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void o.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await mn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await mn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=r.dialog("Save Monomer").add(r.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=un([],e);let t=o.chem.convert(e,s.chem.Notation.Smiles,s.chem.Notation.MolBlock);t=hn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:s.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},a=this.getMonomerLib()?.source;a?await this.addMonomerToLib(r,a):o.shell.warning("Monomer library source is not specified")}}function un(e,t,n){t&&(t=function(e){return e.replaceAll(/\[Allyl\:\d\]/g,e=>`[*:${e[e.length-2]}]`)}(t));const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,s.chem.Notation.Unknown,s.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1";n=n.replace(`[${e.capGroupName}:${t}]`,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(r,e),r=on(r),i?r:o.chem.convert(r,s.chem.Notation.Unknown,s.chem.Notation.Smiles)}function hn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].trim().split(" ").filter(Boolean);if(e.length>=5&&Number.parseInt(e[4])<9){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function dn(e,t){let n=e;return t.forEach((e,t)=>{const i=e.label[1]??`${t+1}`,o=sn(e,"capGroupName"),r=sn(e,"capGroupSMILES");n="allyl"===o?.toLowerCase()||"c=c"===r?.replace(`[*:${i}]`,"")?.toLowerCase()||"[c=c]"===r?.replace(`[*:${i}]`,"")?.toLowerCase()?n.replace(`[*:${i}]`,"C=C"):n.replace(`[*:${i}]`,`[${o}]`)}),n}async function mn(e){let t;try{t=JSON.parse(e.get(Qt.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==s.INT_NULL.toString()&&t[e]!==s.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==s.INT_NULL&&t[e]!==s.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Qt.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,s.chem.Notation.Smiles,s.chem.Notation.MolBlock),i=hn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let r=e.get(Qt.NATURAL_ANALOG);const a=e.get(Qt.POLYMER_TYPE);let l=[];try{l=JSON.parse(e.get(Qt.R_GROUPS)??"[]")}catch(e){l??=[]}!function(e){function t(e,t){return e.replace(/\[([A-Z][a-z]?):(\d+)\]/g,(e,n,i)=>parseInt(i)===t?`${n?.toLowerCase&&"h"===n?.toLowerCase()?"[H]":n}[*:${i}]`:e)}e.forEach((e,n)=>{const i=sn(e,"capGroupSMILES"),o=e.label[1]??`${n+1}`;if(!i||i.includes(`[*:${o}]`))return;const r=new RegExp(`\\[[A-Za-z]{1,2}:${o}\\]`);i.includes(`[*${o}]`)?an(e,"capGroupSMILES",i.replace(`[*${o}]`,`[*:${o}]`)):i.includes(`[R${o}]`)?an(e,"capGroupSMILES",i.replace(`[R${o}]`,`[*:${o}]`)):r.test(i)?an(e,"capGroupSMILES",t(i,Number.parseInt(o))):`[${i}]`.match(r)?.[0].length===i.length+2&&an(e,"capGroupSMILES",t(`[${i}]`,Number.parseInt(o)))}),e.forEach(e=>{const t=sn(e,"capGroupSMILES"),n=t.match(/\[\*\:?(\d+)\]/);n&&t===n[0]&&an(e,"capGroupSMILES",`${sn(e,"capGroupName")}${t}`)})}(l);try{if(!r&&a){const e=await qt(dn(n,l),a);e&&(r=e)}}catch(e){console.error(e)}return{symbol:e.get(Qt.SYMBOL),name:e.get(Qt.NAME),molfile:i,smiles:n,polymerType:a,monomerType:e.get(Qt.MONOMER_TYPE),naturalAnalog:r,id:e.get(Qt.ID),rgroups:l,meta:t,author:e.get(Qt.AUTHOR),createDate:e.get(Qt.CREATE_DATE)}}class pn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:s.Color.toHtml(s.Color.fromHtml(e.line??"#000000")),background:s.Color.toHtml(s.Color.fromHtml(e.background??"#000000")),text:s.Color.toHtml(s.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}const gn=/.*\|\$.*R.*\$\|/,fn=/\[R(\d+)\]/,yn=/\[R(\d+)\]/g,bn=/\[\*:(\d+)\]/g;function wn(e,t){const n=Array.from(e.matchAll(yn)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=hn(o.chem.convert(t,o.chem.Notation.Smiles,o.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){To.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const vn=/[\w()]+/,Cn=RegExp(String.raw`\(${vn}(,${vn})+\)`),Tn=e=>{const t=r.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},An=new Rt.Mi([255,255,255]),En=new Rt.Mi([0,0,0]),Sn=.7*(0,W.wQ)(An);class Mn{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]??{});return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==ge._S||t===ge.b9[ge.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(gn.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return wn(a,t)}let n=e;const i=Array.from(e.matchAll(bn));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(fn.test(n))return wn(n,t)}catch(t){To.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Ot((0,$e.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ee().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];if(i=t?.[n]??null,!i)return this.getMonomer(null,n)}else for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break;return i}getWebEditorMonomer(e,t){const[n,i]=(0,Nt.fA)(e,t),o=(0,_t.Y)(n);let r=this.getMonomer(o,i);if(r&&n==De.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==De.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ge._S||"*"==i?s=r.wem=new Ht(n):n===De.o.NUCLEOTIDE&&"N"===i||n===De.o.AA&&"X"===i||(De.o.CHEM,0)||Cn.test(i)?s=r.wem=new Dt(n,i):r.lib||(s=r.wem=new kt(n,i,this.isEmpty)),s||(s=r.wem=Gt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,_t.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?Tn(s.molfile):s.smiles?r.divV([Tn(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=ge._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),s.polymerType&&i.append(r.divText(s.polymerType,{style:{fontStyle:"italic"}})),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=s.Color.fromHtml(e);return[s.Color.r(n),s.Color.g(n),s.Color.b(n)]},o=i(n.textcolor),r=new Rt.Mi([...o.map(e=>e+1)]),a=(0,W.KE)(r,An)/((0,W.wQ)(r)*(0,W.wQ)(An)),l=i(n.backgroundcolor),c=new Rt.Mi([...l.map(e=>e+.01)]);let u;u=(0,W.KE)(c,An)/((0,W.wQ)(c)*(0,W.wQ)(An))<a?l:o;let h=new Rt.Mi(u);const d=(0,W.wQ)(h);return d>Sn&&(h=(0,W.dC)(En,h,Sn/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,_t.Y)(e),r=this.getMonomer(o,t);let a;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){To.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(a=e[i])}if(!a){const t=Bt[e],n=t?.[r.symbol];n&&(a={textColor:s.Color.toHtml(s.Color.getContrastColor(s.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!a&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return a||(a={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:a.text??a.textColor,linecolor:a.line??a.lineColor,backgroundcolor:a.background??a.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var xn=n(5488),Pn={};Pn.styleTagTransform=C(),Pn.setAttributes=y(),Pn.insert=g().bind(null,"head"),Pn.domAPI=m(),Pn.insertStyleElement=w(),h()(xn.A,Pn),xn.A&&xn.A.locals&&xn.A.locals;class In extends Mn{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,_t.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Lt.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Pe.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ee().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return s.DataFrame.fromColumns([s.Column.fromStrings("polymerType",e),s.Column.fromList(s.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new Ln(e,`override: ${++In.overrideCounter}, ${t}`,this)}}class Ln extends Mn{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var _n=n(8604),Nn=n(7433),Rn=n.n(Nn),$n=n(1913),On=n.n($n);class Hn{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});On()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class Dn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=fe.ic;_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await o.dapi.files.readAsText(Dn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),r=new Hn(i);Dn._instance=new Dn(r,e,t),Dn._instance.refreshLists()}return Dn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(this.LIB_PATH+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),o.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),r=[];for(let e=0;e<i.length;e++){const t={};try{const r=await o.dapi.files.readAsText(i[e]);n=JSON.parse(r),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{r.push(t)}}return r}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,r=this.SETS_PATH+e;try{const e=await o.dapi.files.readAsText(r),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new fe.lH(n,i,o,r,s)});t.push(new fe.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${r}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await o.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i);let s=JSON.parse(r);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return o.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,r=await o.dapi.files.readAsText(i),s=JSON.parse(r);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await o.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}class kn{logger;_monomerLib=new In({},"MAIN");_monomerSets=new fe.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new c.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new c.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new c.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await(0,Ze.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=s.Func.find({meta:{role:"monomer-lib-provider"}});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await Dn.getInstance(this,To.logger)),s.debounce((0,c.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++kn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return kn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=s.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Pe.u)(),i=await this.getProviders(),r=await Promise.all(i.map(async e=>e.listLibraries()));r.forEach((e,n)=>{r[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=r[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new In(e[t],l[t]))}catch(e){o.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=s.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let r=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){o.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++r/t.length),`Loading monomer sets ${r}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Pe.E)(_n.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new In(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===fe.ic);if(!t)throw new Error(`Provider '${fe.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new In(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,fe.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new kn(To.logger))()),e}}var Fn=n(1757),Gn=n.n(Fn);class Bn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Vn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Bn(e));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Un{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Un._instance||(Un._instance=new Un,await Un._instance.refresh(),(await kn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Un._instance.refresh())),Un._instance.refresh(),Un._instance}async refresh(){this.settings=await(0,Pe.u)();const e=await kn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Vn(n,this.monomers[t][n],r,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=r.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void o.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void o.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),o.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else o.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=r.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Wn=n(3017),qn={};async function Yn(){await Xn.showDialog()}async function jn(e=!0){return await Qn.showView(e)}qn.styleTagTransform=C(),qn.setAttributes=y(),qn.insert=g().bind(null,"head"),qn.domAPI=m(),qn.insertStyleElement=w(),h()(Wn.A,qn),Wn.A&&Wn.A.locals&&Wn.A.locals;class Kn{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==Kn.instancePromise&&(Kn.instancePromise=(async()=>{const e=new Kn,t=await(0,fe.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),Kn.instancePromise}static async reloadWidget(){const e=await Kn.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,fe.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new s.Widget(e)}async getWidgetContent(){const e=await zn.createControlsForm();return Gn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&Gn()(e)&&Gn()(e).removeClass("ui-form-condensed")},200),r.divV([e])}async promptToAddLibraryFiles(){s.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{r.dialog("Confirm Library Update").add(r.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),a=s.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{a.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void o.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=r.dialog("Select storage for new monomer library"),a=r.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(a).onOK(async()=>{const e=n.find(e=>e.name===a.value);await t(e)}).show()}})}}class zn{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){To.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Pe.u)(),t=await(0,fe.pj)();return new zn(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=r.wideForm(e,void 0);return Gn()(t).addClass("monomer-lib-controls-form"),t}async updateControlsForm(){const e=await this._createControlsForm();Gn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;To.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{Zn(i.value,e)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const s=r.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=r.icons.edit(async()=>{o.shell.v=await(await nn.getInstance()).getViewRoot(e)},"Edit monomer library");return r.tooltip.bind(s,`Delete ${e}`),i.addOptions(a),i.addOptions(s),To.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=s.TaskBarProgressIndicator.create(`Deleting ${e} library`);await Zn(!1,e);const n=await(0,fe.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function Zn(e,t){const n=await(0,Pe.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Pe.E)(n);const i=await(0,fe.pj)();await i.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class Xn{constructor(){}static _instance;dialog;closeDialogSubject$=new c.Subject;static async showDialog(){Xn._instance||(Xn._instance=new Xn,Xn._instance.closeDialogSubject$.subscribe(()=>{Xn._instance.dialog=void 0})),Xn._instance.dialog||(Xn._instance.dialog=await Xn._instance.getDialog()),Xn._instance.dialog.show()}async getDialog(){const e=(await Kn.getInstance()).widget,t=await(0,fe.pj)(),n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Gn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class Qn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await Kn.getInstance()).widget,n=r.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=r.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),a=r.splitH([r.divV([t.root,r.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=s.View.fromRoot(a),this._view.name=Qn.viewName,e&&o.shell.addView(this._view),r.tools.waitForElementInDom(a).then(()=>{setTimeout(()=>{const e=Array.from(a.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe(()=>{try{const e=Qn._instance;e&&e._view&&o.shell.v&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return Qn._instance||(Qn._instance=new Qn),Qn._instance._duplicateManager||(Qn._instance._duplicateManager=await Un.getInstance()),Qn._instance.libManager||(Qn._instance.libManager=await kn.getInstance()),e&&Qn._instance._view&&Array.from(o.shell.views).find(e=>e.id&&e.id===Qn._instance._view.id)?(o.shell.v=Qn._instance._view,await Qn._instance._duplicateManager.refresh(),Qn._instance._view):(Qn.closeExistingViews(),Qn._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter(e=>e.name===Qn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await kn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),a=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(a.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}a.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void o.shell.error("No monomer library providers available to save the merged library.");const h=r.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(a).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{s.Utils.download((()=>{let e=a.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!a.value||!a.value.trim()||!h.value)return h.validate(),void a.validate();i.close();const e=a.value,t=JSON.stringify(n);this._view&&r.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Pe.u)();i.exclude=l,await(0,Pe.E)(i),await this.libManager.loadMonomerLib(!0),await Kn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Jn,ei=n(8070),ti=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ni{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe(e=>ti(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",()=>{o.shell.v.close(),o.shell.v=s.View.createByType(s.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),()=>ti(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),()=>ti(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),()=>ti(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,ni.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return ti(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],a=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",a.classList.remove("hidden"),a.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,ei.cb)(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof s.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return ti(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return ti(this,void 0,void 0,function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return ti(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return ti(this,void 0,void 0,function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ni.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return ti(this,void 0,void 0,function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),this._node=o.shell.dockManager.dock(this._root,s.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ni.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Jn||(Jn={}));var ii=n(966),oi=n(608),ri=n(1619);class si{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ee()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${To.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case et.n5.fixWidth:case et.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ai{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE)})}}var li=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ci="-";class ui extends Ge{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Ne.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ge._S||(a=ci);const l=a.split(ge.ot).map(e=>e&&e!==ge._S?e.trim():ci),c=l.map(e=>(0,ue.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),u=c.map(t=>e.measureText(t).width),h=u.reduce((e,t)=>e+t,0);let d=t+(i-h)/2;const m=this.tableCol.getTag(ge.gp.alphabet),p=m===ue.YI.RNA||m===ue.YI.DNA?li.o.NUCLEOTIDE:li.o.AA;for(let a=0;a<c.length;a++){const h=l[a],m=this.getHelmType(r,p);let g=Re.S$,f="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,h);g=e?.textcolor??g,f=e?.backgroundcolor??f}else g=this.monomerLib.getMonomerTextColor(m,h);s&&1==l.length&&(e.fillStyle=f,e.fillRect(t,n,i,o)),e.fillStyle=g,e.fillText(c[a],d,n+o/2,i),d+=u[a]}}finally{e.restore()}}onMouseMove(e,t){const[n,i,o]=(0,He.BG)(e);if(e.grid.dart!=this.gridCol?.grid.dart||n?.dart!=this.gridCol?.dart||!i||!e.isTableCell)return!1;const s=i.getTag(ge.gp.alphabet),a=e.cell.value,l=e.grid.canvas.getBoundingClientRect(),c=e.bounds.right+l.left-4,u=e.bounds.bottom+l.top-4;if(!a||a==ge._S||a==ci)return r.tooltip.show(r.divText("gap"),c,u),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),c,u),!0;const h=s===ue.YI.RNA||s===ue.YI.DNA?li.o.NUCLEOTIDE:li.o.AA,d=a.split(ge.ot).map(t=>{if(!t||t===ge._S||t===ci)return r.divText("gap");const n=this.getHelmType(e,h);return this.monomerLib.getTooltip(n,t)}),m=r.divH(d,{style:{alignItems:"top"}}),p=Array.from(m.querySelectorAll("canvas"));if(p.length>2){const e=Math.floor(550/p.length);p.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return r.tooltip.show(m,c,u),!0}getHelmType(e,t){let n=t;const[i,o,r]=(0,He.BG)(e);if((e.tableRowIndex??-1)>-1&&o?.getTag(ge.qE.polymerTypeColumnName)){const t=o.getTag(ge.qE.polymerTypeColumnName),i=o.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,$e.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,He.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ui(t,n)),o}}class hi extends s.GridCellRenderer{get name(){return Be.uF.MONOMER}get cellType(){return Be.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){ui.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){ui.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class di{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class mi extends Map{_onPropertyChanged=new c.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class pi extends s.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new di(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,be.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var gi=n(6307),fi=n(5999),yi={};yi.styleTagTransform=C(),yi.setAttributes=y(),yi.insert=g().bind(null,"head"),yi.domAPI=m(),yi.insertStyleElement=w(),h()(fi.A,yi),fi.A&&fi.A.locals&&fi.A.locals;class bi extends s.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=To.properties.tooltipWebLogo,n=this.seqCol.getTag(Xe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function wi(e,t,n,i){const o=To.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const vi={df:s.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ue.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Ci{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??vi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ue.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ue.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${To.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,s.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Ti{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(s.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ue.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{To.handleErrorUI(e)})}).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=r.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{To.handleErrorUI(e)})});return s.Widget.fromRoot(r.divV([e,r.div(t)]))}}var Ai=n(8754);async function Ei(e,t,n,i,r){const a=await async function(e,t,n,i,r){const a=me(t,r),l=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=r.getSeqHandler(l).getSplitted(0),u=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ge._S;r[s]=n.categories.indexOf(a)}const a=s.Column.float("Identity",t.rowCount),l=a.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return a}(c,a):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),r=await async function(e,t,n){e instanceof s.Column&&(e=me(e,n).columns.toList());const i=(await(0,fe.pj)()).getMonomerLib(),r=new Array(e.length),a=e[0].length,l=new Float32Array(a);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):ge._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),m=h.categories,p=m.indexOf("");if(r[n]={categories:m,data:d,emptyIndex:p},void 0===c)continue;const g=s.Column.fromStrings("smiles",m.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(s.DataFrame.fromColumns([g]),await o.chem.getSimilarities(g,u)),y=f?f.getRawData():null;for(let e=0;e<a;++e){const t=d[e];c!==ge._S&&t!==p?l[e]+=y[t]:c===ge._S&&t===p&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let o=0;o<e.length;++o){const e=r[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=s.FLOAT_NULL;break}}l[n]=i}return s.Column.fromFloat32Array("Similarity",l)}(i,e,n);return r}(c,a,r):null;if(null===u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,r);for(let e=0;e<a.length;e++)t.isNone(e)&&a.set(e,null,!1);return a}var Si=n(294),Mi=n(330);const xi=OCL;var Pi=n(2582);class Ii{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e,t){this.rGroups.capRGroups(e,t)}}var Li=n(6956);class _i{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e,t){this.rGroupIdToAtomicIndexMap.forEach((n,i)=>{const o=e.find(e=>e.rGroupId===i)??e[i-1];o.isSimple?o.element===Li.m?(this.removeRGroups([i]),this.deleteBondLineWithSpecifiedRGroup(i)):this.atoms.replaceRGroupSymbolByElement(n,o.element):this.capWithComplexGroup(n,o.smiles,t)})}capWithComplexGroup(e,t,n){const i=t.replace(/\[\*:\d+\]/g,"[Xe]"),o=n.get_mol(i);if(!o)throw new Error(`Cannot parse cap group SMILES: ${t}`);let r;try{r=o.get_v3Kmolblock()}finally{o.delete()}const s=Lt.getInstance(r),a=s.getAtomLines(),l=s.pairsOfBondedAtoms,c=s.getBondLines(),u=s.x,h=s.y,d=s.atomTypes;let m=-1;for(let e=0;e<d.length;e++)if("Xe"===d[e]){m=e;break}if(-1===m)throw new Error(`Cannot find placeholder atom in cap group SMILES: ${t}`);let p=-1;for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1){p=n-1;break}if(n===m+1){p=t-1;break}}if(-1===p)throw new Error(`Cannot find attachment atom in cap group SMILES: ${t}`);const g=this.atoms.atomCoordinates[e],f=g.x-u[p],y=g.y-h[p],b=d[p];this.atoms.replaceRGroupSymbolByElement(e,b);const w=new Map;w.set(p+1,e+1);let v=this.atoms.count+1;for(let e=0;e<a.length;e++){if(e===m||e===p)continue;const t=u[e]+f,n=h[e]+y;this.atoms.appendAtomLine(a[e],t,n),w.set(e+1,v),v++}for(let e=0;e<l.length;e++){const[t,n]=l[e];if(t===m+1||n===m+1)continue;const i=w.get(t),o=w.get(n);this.bonds.appendBondLine(c[e],[i,o])}}}class Ni{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}appendAtomLine(e,t,n){this.rawAtomLines.push(e),this.coordinates.push({x:t,y:n})}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Ri extends Ni{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class $i{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}appendBondLine(e,t){this.rawBondLines.push(e),this.bondedAtomPairs.push(t)}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Oi extends $i{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Hi extends Ii{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new Ri(n),this.bonds=new Oi(n),this.rGroups=new _i(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Di extends Ni{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class ki extends $i{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Fi extends Ii{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new Di(n),this.bonds=new ki(n),this.rGroups=new _i(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Gi{static getInstance(e,t){if(Lt.isMolfileV2K(e))return new Hi(e,t);if(Lt.isMolfileV3K(e))return new Fi(e,t);throw new Error("Unsupported molfile version")}}class Bi{monomerSymbol;monomerIdx;helm;rdKitModule;monomerLib;molfileWrapper;capGroupInfo=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.rdKitModule=o,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Lt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Gi.getInstance(a,e),this.capGroupInfo=this.getCapGroupInfo(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Bi.molfileV2KToV3KCache.has(e))return Bi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Bi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupInfo(e){return e.rgroups.map((e,t)=>{const n=e.capGroupSmiles||e.capGroupSMILES;let i=e.label[1];if(!i||!parseInt(i)||isNaN(parseInt(i))){const e=n?.match(/\[\*:(\d)\]/);e&&e[1]&&(i=e[1])}i&&parseInt(i)&&!isNaN(parseInt(i))||(i=`${t+1}`);const o=n.replace(/(\[|\]|\*|:|\d)/g,"");return{element:o,smiles:n,isSimple:(r=o,/^[A-Z][a-z]?$/.test(r)),rGroupId:parseInt(i)};var r})}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupInfo,this.rdKitModule)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Vi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Pi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ge.b9[ue.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Bi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Si.Cg;for(const[n,o]of ee().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?De.o.NUCLEOTIDE:De.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ee().count(r).take(n.atomCount).toArray(),bonds:ee().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M V30 END BOND"].join("\n")}}class Ui{constructor(e){this.molfileHandler=Lt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Wi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return s.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>s.chem.convert(e,s.chem.Notation.MolBlock,s.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return xi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,be.AP)(e);return To.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=s.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),s.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),a=`molfile(${e.name})`,l=o?o.columns.getUnusedName(a):a;return t?this.getMolV3000ViaOCL(r,l):s.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,Mi.kA)(t,`molfileV3K(${e.name})`);return s.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Si.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,be.AP)(e);To.logger.error(t,void 0,n),o=Si.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return s.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Ui(o),s=new Vi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Si.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Si.vF(a.molfile,l)}}var qi=n(2738);class Yi{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[Le.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[Le.j.notationProvider]??null);const i=this.isFasta()?ge.b9[ue.Hi.FASTA]:this.isSeparator()?ge.b9[ue.Hi.SEPARATOR]:this.isHelm()?ge.b9[ue.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ge.b9[ue.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ue.gp.aligned)||!this.column.tags.has(ue.gp.alphabet)||!this.column.tags.has(ue.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ue.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ue.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ue.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ue.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ue.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ee().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=s.Func.find({meta:{role:"notationRefiner"}});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[Le.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ue.Hi.FASTA,ue.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ue.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ue.gp.aligned);null==t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ue.gp.aligned,t));let n=e.column.getTag(ue.gp.alphabet);if(null==n&&(n=(0,$e.pc)(e.stats.freq,ue.q7),e.column.setTag(ue.gp.alphabet,n)),n===ue.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ue.gp.alphabetSize,t.toString()),e.column.setTag(ue.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ue.Hi.HELM){let t=e.column.getTag(ue.gp.alphabet);if(null==t){const n=ue.q7.map(e=>new qi.aD(e.name,e.alphabet,.9));t=(0,$e.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(ue.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ue.gp.separator)??void 0;if(this.notation===ue.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ue.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ue.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ue.YI.RNA||this.alphabet===ue.YI.DNA?De.o.NUCLEOTIDE:De.o.AA}get helmCompatible(){return this.column.getTag(ue.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ue.Hi.HELM||this.alphabet==ue.YI.UN){const e=this.column.getTag(ue.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ue.YI.PT:return 20;case ue.YI.DNA:case ue.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ue.Hi.HELM||this.alphabet===ue.YI.UN&&"true"===this.column.getTag(ue.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ge.b9[ue.Hi.FASTA]?ge._S:i??ge._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ge._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ge.b9[ue.Hi.FASTA]?ge._S:o??ge._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new Le.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ue.Hi.HELM?n:this.notation===ue.Hi.CUSTOM||this.notation===ue.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ue.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ue.YI.DNA||e===ue.YI.RNA||e===ue.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:ee().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(ue.gp.positionNames);this._posList=e?e.split(ue.z1).map(e=>e.trim()):ee().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ue.Hi.FASTA}isSeparator(){return this.notation===ue.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ue.Hi.HELM}isCustom(){return this.notation===ue.Hi.CUSTOM}isBiln(){return this.notation===ue.Hi.BILN}isRna(){return this.alphabet===ue.YI.RNA}isDna(){return this.alphabet===ue.YI.DNA}isPeptide(){return this.alphabet===ue.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return ue.Hi.FASTA;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return ue.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.Hi.HELM;if(this.units.toLowerCase().startsWith(ue.Hi.CUSTOM))return ue.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ue.Hi.BILN))return ue.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",a=n??o.dataFrame?.columns.getUnusedName(r)??r,l=s.Column.fromList("string",a,i??new Array(this.column.length).fill(""));if(l.semType=s.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ue.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ue.Hi.SEPARATOR}' requires separator value.`);l.setTag(ue.gp.separator,t)}l.setTag(s.TAGS.CELL_RENDERER,e===ue.Hi.HELM?"helm":"sequence");const c=o.getTag(ue.gp.aligned);c&&l.setTag(ue.gp.aligned,c);let u=o.getTag(ue.gp.alphabet);u||this.notation!==ue.Hi.HELM||e===ue.Hi.HELM||(u=ue.YI.UN),null!=u&&l.setTag(ue.gp.alphabet,u);let h=o.getTag(ue.gp.alphabetSize);null!=u&&h&&l.setTag(ue.gp.alphabetSize,h);const d=o.getTag(ue.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ue.gp.alphabetIsMultichar,d),e==ue.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ue.gp.alphabetSize,h)),e===ue.Hi.BILN&&(l.setTag(ue.gp.separator,"-"),l.meta.units=ue.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ue.Hi.FASTA,ue.Hi.SEPARATOR,ue.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!Yi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=s.Column.fromList("string",t,new Array(e).fill(""));return i.semType=s.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ue.Hi.FASTA))return null===this.column.getTag(ue.gp.alphabet)||this.getAlphabetIsMultichar()?ue.J9:$e.tm;if(this.units.toLowerCase().startsWith(ue.Hi.SEPARATOR))return(0,ue.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ue.Hi.HELM))return ue.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ce.Z.HAMMING;switch(this.alphabet){case ue.YI.DNA:case ue.YI.RNA:case ue.YI.PT:}return ce.Z.LEVENSHTEIN}getDistanceFunction(){return ce.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ue.gp.isHelmCompatible))return"true"===this.column.getTag(ue.gp.isHelmCompatible);const e=(await(0,fe.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ue.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ue.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ue.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ue.Hi.FASTA}toSeparator(e){return e===ue.Hi.SEPARATOR}toHelm(e){return e===ue.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ge.b9[ue.Hi.FASTA]:ge.b9[ue.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ue.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(de.EK,"$1")),n===ge.b9[ue.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){if(this.isCustom()&&e===ue.Hi.HELM){if(!this.notationProvider||!this.notationProvider.getHelm)throw new Error("Notation provider with getHelm function is required for custom notation conversion.");const n=this.getNewColumn(e,t);return n.init(e=>{const t=this.column.get(e);return this.notationProvider.getHelm(t,{})}),n}{const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ge.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new $e.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ue.z1)},u=this.column.getTag(ue.gp.positionNames);u&&i.setTag(ue.gp.positionNames,c(u));const h=this.column.getTag(ue.gp.positionLabels);return h&&i.setTag(ue.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ue.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ue.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return ji(e,n,o.isHelm())};break;case ue.Hi.HELM:{const e=o.alphabet===ue.YI.DNA||o.alphabet===ue.YI.RNA,t=o.getHelmWrappers();i=function(n){return Ki(n,t,e)};break}case ue.Hi.BILN:i=function(e){return zi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ue.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ue.Hi.SEPARATOR}'.`);const n=this;if(e===ue.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ue.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ue.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ue.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[Le.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Le.j.seqHandler]=new Yi(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(de.EK,"$1")),o===ge._S?r=ge.b9[ue.Hi.FASTA]:o===de.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return ji(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ue.Hi.HELM)return e;if(this.isCustom()&&this.notationProvider?.getHelm)return this.notationProvider.getHelm(e,{});const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return Ki(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ue.Hi.BILN?e:zi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(de.EK,"$1"),r=r===de.q7?null:r),n[e]=r||null}return new $e.Mu(n.filter(e=>!!e),ge.b9[ue.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function ji(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(de.EK,"$1")),o===ge._S?r=ge.b9[ue.Hi.SEPARATOR]:o===de.q7&&(r=""),i[t]=r}return i.join(t)}function Ki(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ge._S?r=ge.b9[ue.Hi.HELM]:(n&&(r=r.replace(de.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ge._S?s=ge.b9[ue.Hi.HELM]:(n&&(s=s.replace(de.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function zi(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class Zi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Yi.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Nt.b2)();return new Wi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Si.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Si.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Si.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Si.vF(e,o.monomers)}catch(e){const[t,n]=(0,be.AP)(e);return To.logger.error(t,void 0,n),Si.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),a=e.dataFrame,l=(0,Mi.qj)(a,e.name),c=await this.getHelmToMolfileConverter(r),u=e.toList(),h=new Array(e.length),d=s.Func.find({package:"Chem",name:"beautifyMols"})[0],m=s.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!m,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&m){const t=await m.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else o.shell.warning("OCL function returned an unexpected result")}const p=s.Column.fromStrings(l,h);return p.semType=s.SEMTYPE.MOLECULE,p.meta.units=s.UNITS.Molecule.MOLBLOCK,p.setTag(".sequence-src-col",e.name),{molCol:p,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ue.Hi.FASTA)throw new Error(`The column of notation '${ue.Hi.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ue.Hi.FASTA,Yi.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ue.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ue.Hi.SEPARATOR,e.column.setTag(ue.gp.separator,t),Yi.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ue.Hi.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ue.Hi.HELM,Yi.setTags(e)}}async function Xi(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};const n=(await Eo.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=s.Column.fromStrings("singleVal",[e.value]),o=s.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[Le.j.notationProvider]&&(i.temp[Le.j.notationProvider]=e.cell.column.temp[Le.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),a=(r.graphInfo?.connections?.length??0)>0||n.units===ue.Hi.CUSTOM,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Eo.toAtomicLevel(o,i,a||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){To.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Qi="#333333",Ji="rgba(60, 177, 115, 0.1)",eo="rgba(240, 240, 240, 0.5)",to="rgba(100, 100, 100, 0.3)";class no{constructor(e=ro.DEFAULT_TRACK_HEIGHT,t=ro.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class io extends no{constructor(e=new Map,t=ro.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,ro.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=De.o.NUCLEOTIDE;break;default:t=De.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,gi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const m=t+e*s,p=s-2;r+e===l&&(this.ctx.fillStyle=Ji,this.ctx.fillRect(m,n,s,o)),this.ctx.fillStyle=eo,this.ctx.fillRect(m+1,c,p,u),this.drawLettersInColumn(h,m,p,c,u,d),this.drawColumnBorder(m,c,p,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=to,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=s.Color.fromHtml(t),n=s.Color.getContrastColor(e);return s.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class oo extends no{constructor(e,t=ro.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,ro.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=Ji,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=eo,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=to,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Qi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const ro={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},so={BASE:ro.DOTTED_CELL_HEIGHT+ro.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+ro.TITLE_HEIGHT+ro.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+ro.DEFAULT_TRACK_HEIGHT+ro.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+ro.DEFAULT_TRACK_HEIGHT+ro.TRACK_GAP}};class ao{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||so.BASE,sliderHeight:e.sliderHeight||ro.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(ro.DEFAULT_TRACK_HEIGHT)}),!(e<so.WITH_TITLE()||e<so.WITH_WEBLOGO()))if(e<so.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-so.WITH_WEBLOGO();t.setHeight(ro.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>so.WITH_BOTH()){const n=e-so.WITH_BOTH();t.setHeight(ro.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<so.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<so.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=so.WITH_TITLE()?(ro.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=so.WITH_TITLE()?ro.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=so.WITH_WEBLOGO();else{if("conservation"!==e)return;t=so.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?so.WITH_BOTH():so.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=so.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,ro.TITLE_HEIGHT),this.ctx.fillStyle=Qi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+ro.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof io&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=so.WITH_TITLE()?ro.TITLE_HEIGHT:0,l=this.config.headerHeight-ro.SLIDER_HEIGHT-ro.DOTTED_CELL_HEIGHT,c=l-ro.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[],m=this.getTrack("weblogo");m&&m.isVisible()&&d.push({id:"weblogo",track:m});const p=this.getTrack("conservation");p&&p.isVisible()&&d.push({id:"conservation",track:p});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){u=e,h=n-i;break}g=i-ro.TRACK_GAP}let f=null;if(u){const e=this.tracks.get(u);e&&(f=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=f,u)){const e=this.tracks.get(u);e instanceof io&&(e.setHovered(s,f),window.requestAnimationFrame(()=>this.redraw()))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=f,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,f);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=so.WITH_TITLE();l&&ro.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-ro.SLIDER_HEIGHT,u=c-ro.DOTTED_CELL_HEIGHT,h=u-ro.TRACK_GAP,d=[],m=[],p=this.getTrack("weblogo");p&&p.isVisible()&&m.push({id:"weblogo",track:p});const g=this.getTrack("conservation");g&&g.isVisible()&&m.push({id:"conservation",track:g});let f=h;for(const{track:e}of m){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-ro.TRACK_GAP}if(this.drawDottedCells(0,u,n,ro.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:ro.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+ro.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,m=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(m,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Qi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),m,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,ro.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,ro.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,ro.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-ro.SLIDER_HEIGHT;return t>n&&t<n+ro.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-ro.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+ro.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=so.WITH_TITLE()?ro.TITLE_HEIGHT:0,a=this.config.headerHeight-ro.SLIDER_HEIGHT-ro.DOTTED_CELL_HEIGHT,l=a-ro.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const m=this.getTrack("conservation");m&&m.isVisible()&&h.push({id:"conservation",track:m});let p=l;for(const{id:e,track:t}of h){const i=p-t.getHeight();if(n>=i&&n<p){c=e,u=n-i;break}p=i-ro.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=so.WITH_TITLE()&&t&&(lo(e.left??0,n,i)||lo(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}detach(){this.eventElement.remove(),window.removeEventListener("keydown",this.handleKeyDown.bind(this))}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-ro.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:so.BASE,WITH_TITLE:so.WITH_TITLE(),WITH_WEBLOGO:so.WITH_WEBLOGO(),WITH_BOTH:so.WITH_BOTH()}}}function lo(e,t,n){return e>=t&&e<=n}class co{static conservationCache=new s.LruCache(100);static webLogoCache=new s.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){co.conservationCache=new s.LruCache(100),co.webLogoCache=new s.LruCache(100),co.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return co.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return co.conservationCache.getOrCreate(i,()=>{const o=co.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return co.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/co.CHUNK_SIZE)*co.CHUNK_SIZE,s=Math.ceil(n/co.CHUNK_SIZE)*co.CHUNK_SIZE;for(let t=r;t<s;t+=co.CHUNK_SIZE){const n=Math.min(t+co.CHUNK_SIZE,i),r=co.getChunkCacheKey(e.column,t,n),s=co.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/co.CHUNK_SIZE)*co.CHUNK_SIZE,s=Math.ceil(n/co.CHUNK_SIZE)*co.CHUNK_SIZE;for(let t=r;t<s;t+=co.CHUNK_SIZE){const n=Math.min(t+co.CHUNK_SIZE,i),r=co.getChunkCacheKey(e.column,t,n),s=co.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class uo extends io{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=co.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class ho extends oo{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=co.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=co.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const mo="__msa-scroller-initialized",po="__msa-scroller-subscription";class go extends qi.$G{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}static get notationName(){return ge.Hi.BILN}static get implementsFromHelm(){return!1}static convertFromHelm(e,t){throw new Error("Canonical way of converting from helm to biln must be used")}constructor(e,t,n){super(),this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=$e.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ge.Hi.HELM})(n)}createCellRendererBack(e,t){const n=To.properties.maxMonomerLength||4,i=new fo(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class fo extends Re.Jy{constructor(e,t,n,i){super(e,t,To.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Re.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:$e.zS}})}}var yo,bo;!function(e){e.embed=async function(e){return await o.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await o.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,r,s,a,l,c,u,h,d,m,p,g,f,y){return await o.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:r,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:m,disable_negatives:p,fasta_separator:g,helm_library_file:f,helm_connection_mode:y})}}(yo||(yo={})),function(e){e.test1=async function(){return await o.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await o.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await o.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await o.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await o.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await o.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await o.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await o.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await o.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await o.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await o.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await o.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await o.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await o.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await o.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await o.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await o.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await o.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await o.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await o.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await o.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await o.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,r){return await o.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:r})},e.webLogoViewer=async function(){return await o.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await o.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await o.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,r){return await o.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:r})},e.activityCliffs=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:r,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,r){return await o.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:r})},e.helmPreprocessingFunction=async function(e,t){return await o.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,r,s,a,l,c){return await o.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:r,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.moleculesToHelmTopMenu=async function(e,t){return await o.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.moleculeToHelmSingle=async function(e){return await o.functions.call("Bio:MoleculeToHelmSingle",{molecule:e})},e.toAtomicLevel=async function(e,t,n,i){return await o.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await o.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await o.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.toAtomicLevelSingleSeq=async function(e){return await o.functions.call("Bio:ToAtomicLevelSingleSeq",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await o.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await o.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await o.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.compositionAnalysis=async function(){return await o.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await o.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await o.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await o.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await o.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await o.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await o.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await o.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await o.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await o.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await o.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await o.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await o.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await o.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await o.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await o.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await o.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await o.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await o.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(){return await o.functions.call("Bio:ManageMonomerLibrariesView",{})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await o.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.saveAsFasta=async function(){return await o.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await o.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await o.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await o.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await o.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await o.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await o.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await o.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await o.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await o.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await o.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await o.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await o.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await o.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await o.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await o.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await o.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await o.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await o.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await o.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await o.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(bo||(bo={}));var wo=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},vo=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Co=function(e,t){return function(n,i){t(n,i,e)}};const To=new pi;let Ao=null;o.decorators||(o.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{o.decorators[e]||(o.decorators[e]=function(e){return function(e,t,n){}})});class Eo{static async getMonomerLibHelper(){return await kn.getInstance()}static async initBio(){null==Ao&&(Ao=async function(){const e="Bio: _package.initBio()";To.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Ie.j)(),i=await To.getProperties(),r=new mi(i);To.properties=r;const a=await kn.getInstance(),l=await(0,Pe.u)();l.explicit&&(l.explicit=[],await(0,Pe.E)(l)),await a.awaitLoaded(1/0),a.initialLoadCompleted||await a.loadMonomerLib(),a.loadMonomerSets();const u=a.getMonomerLib(),h=a.getMonomerSets(),d=window.performance.now();To.logger.debug(`${e}, loading ET: ${d-t} ms`);const m=new Zi(a,n);To.completeInit(m,u,h,n),To.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;t.temp[po]||(t.temp[po]=[]);let i=t.temp[po];i.forEach(e=>e.unsubscribe()),t.temp[po]=i=[];const r=e=>{i.push(e)},a=n.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);r(s.debounce(c.merge(n.onColumnsAdded,n.onColumnsRemoved,n.onSemanticTypeDetected,t.onEvent("d4-data-frame-changed")),200).subscribe(()=>e(t)));for(const e of a){const i=t.col(e.name);if(!i)continue;const a=!0===i.temp[mo];i.temp[mo]=!0;let l=null;try{l=To.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!l)continue;if(l.isHelm()||l.alphabet===ue.YI.UN)continue;let u=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const h=(e,t)=>Number.isNaN(e)||null==e?t:e,d=()=>h(Math.max(Number.parseInt(e.getTag(ue.gp.positionShift)??"0"),0),0)+1,m=()=>h(Number.parseInt(e.getTag(ue.gp.selectedPosition)??"-2"),-2),p=()=>Re.Jy.getFontSettings(e).fontWidth;let g=0,f=0;const y=e.categories;for(let e=0;e<y.length;e++){const t=y[e];t&&t.length>f&&(f=t.length,g=e)}const b=y[g],w=l.splitter(b),v=w?w.length:30,C={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let T;T=e.length>1e5||v<50?C.WITH_TITLE:e.length>5e4?C.WITH_WEBLOGO:C.WITH_BOTH;let A=null,E=null;const S=s.debounce(c.merge(n.onFilterChanged,n.onDataChanged.pipe((0,R.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{co.clearAllCaches(),A&&(A.resetViewportTracking(),A.forceUpdate()),E&&(E.resetViewportTracking(),E.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});r(S);const M=o=>{const c=[],h=new ho(l,v,45,"default","Conservation");E=h,c.push({id:"conservation",track:h,priority:1});const g=new uo(l,v,45,"WebLogo");A=g,o&&(g.setMonomerLib(o),g.setBiotype(l.defaultBiotype||"HELM_AA")),g.setupDefaultTooltip(),c.push({id:"weblogo",track:g,priority:2});const f=new ao({canvas:t.overlay,headerHeight:T,totalPositions:v+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=d(),r=m();if(o!==i.start&&e.setTag(ue.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(ue.gp.selectedPosition,n.toString()),n>=0&&!u&&t.tableView&&ee()(t.dataFrame?.columns.numerical).find(e=>!0))){u=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<C.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);f.setupTooltipHandling(),c.forEach(({id:e,track:t})=>{f.addTrack(e,t)}),f.setSelectionData(n,e,l),v>50&&!a&&(t.props.colHeaderHeight=T,setTimeout(()=>{t.isDetached||(i.width=400)},300)),r({unsubscribe:()=>f.detach()});const y=i.column;r(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.tableColumn?.dart!==y?.dart)return;const i=t.bounds;if(!i)return;f.headerHeight=i.height;const o=p();f.positionWidth=o+8;const r=d();f.draw(i.x,i.y,i.width,i.height,m(),r,t,e.name)}))};(0,fe.pj)().then(e=>{const t=e.getMonomerLib();M(t)}).catch(e=>{o.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(o.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof s.Grid))return;const n=t.args.viewer;e(n)}),o.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Ao}static sequenceTooltip(e){const t=new bi(e,To.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await en(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const r=n.duplicateMonomers?.[i]??{},a=s.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!a)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const l=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),c=await en(l);c.forEach((e,t)=>{e.lib=l[t].lib});const{cappedMap:u,uncappedMap:h}=await async function(e,t,n){const i={};for(const t of e){if(!t.smiles)continue;const e={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source??""};i[t.smiles]||(i[t.smiles]=[]),i[t.smiles].push(e)}const o=e.map((e,n)=>({symbol:e.symbol,smiles:dn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:t[n]?.lib?.source??""})).filter(e=>!!e.smiles&&!e.smiles.includes("[*:")),r=s.Column.fromList(s.COLUMN_TYPE.STRING,"CappedSmiles",o.map(e=>e.smiles));r.semType=s.SEMTYPE.MOLECULE;const a=await n.apply({molecule:r,targetNotation:s.chem.Notation.Smiles});if(!a||a.length!==r.length)throw new Error("Error canonicalizing capped monomer SMILES");const l={},c=a.toList();for(let e=0;e<c.length;e++){const t=c[e];if(!t)continue;o[e].smiles=t;const n=o[e];l[t]||(l[t]=[]),l[t].push(n)}return{cappedMap:l,uncappedMap:i}}(c,l,a),d=await async function(e,t,n){const i=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return un([],t?void 0:e,t?e:void 0)}catch(t){return e}}),o=s.Column.fromList(s.COLUMN_TYPE.STRING,"MoleculesCorrected",i);o.semType=s.SEMTYPE.MOLECULE,s.DataFrame.fromColumns([o]);const r=await n.apply({molecule:o,targetNotation:s.chem.Notation.Smiles});if(!r||r.length!==o.length)throw new Error("Error canonicalizing molecules");return r.toList()}(e,t,a),m=new Array(d.length).fill(null).map(()=>[]),p=[];for(let e=0;e<d.length;e++){const t=d[e];if(!t)continue;const n=zt(t,u,h);n.length>0?m[e]=n:p.push(e)}if(p.length>0)try{const{fpMap:e}=await async function(e){const t=Object.keys(e);if(0===t.length)return{fpMap:{},cappedSmilesList:[]};const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MonomerSmiles",t);n.semType=s.SEMTYPE.MOLECULE;const i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r={};for(let n=0;n<i.length;n++){const o=i.get(n);if(!o)continue;const s=o.toBinaryString(),a=e[t[n]]??[];r[s]||(r[s]=[]),r[s].push(...a)}return{fpMap:r,cappedSmilesList:t}}(u),t=await async function(e,t,n){const i=new Map;if(0===e.length||0===Object.keys(n).length)return i;const r=e.map(e=>t[e]??""),a=r.map(e=>{if(!e)return"";const t=dn(e,Kt);return t!==e?o.chem.convert(t,s.chem.Notation.Unknown,s.chem.Notation.Smiles):e}),l=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMols",r);l.semType=s.SEMTYPE.MOLECULE;const c=s.Column.fromList(s.COLUMN_TYPE.STRING,"UnmatchedMolsCapped",a);c.semType=s.SEMTYPE.MOLECULE;const[u,h]=await Promise.all([o.functions.call("Chem:getMorganFingerprints",{molColumn:l}),o.functions.call("Chem:getMorganFingerprints",{molColumn:c})]);for(let t=0;t<e.length;t++){const o=e[t],r=u.get(t);if(r){const e=n[r.toBinaryString()];if(e&&e.length>0){i.set(o,e);continue}}const s=h.get(t);if(s){const e=n[s.toBinaryString()];e&&e.length>0&&i.set(o,e)}}return i}(p,d,e);for(const[e,n]of t)m[e]=n}catch(e){console.warn("Fingerprint fallback matching failed, continuing with SMILES matches only:",e)}const g=e.clone(),f=g.columns.addNewString(g.columns.getUnusedName("Matched monomer symbol")),y=g.columns.addNewString(g.columns.getUnusedName("Matched monomer smiles"));y.semType=s.SEMTYPE.MOLECULE;const b=g.columns.addNewString(g.columns.getUnusedName("Matched monomer source")),w=g.columns.addNewInt(g.columns.getUnusedName("Match count")),v=g.columns.addNewString(g.columns.getUnusedName("Match method"));g.columns.setOrder([t,f.name,y.name,b.name,w.name,v.name]);for(let e=0;e<m.length;e++){const t=m[e];if(0===t.length)continue;const n=Zt(t),i=Xt(n,r);f.set(e,n.map(e=>e.symbol).join(" | "),!1),y.set(e,n[0].original??n[0].smiles,!1),b.set(e,i,!1),w.set(e,n.length,!1);const o=p.includes(e)?"fingerprint":"exact";v.set(e,o,!1)}return g}(e,t.name,To.monomerLib,n);o.shell.addTableView(i)}static getBioLib(){return To.monomerLib}static getSeqHandler(e){return To.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=s.Func.find({package:To.name,name:t});if(1!==n.length)throw new Error(`Package '${To.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new Ti(i,To.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return Gn()(e).addClass("d4-link-action"),e.onclick=async()=>await Yn(),new s.Widget(e)}()}static GetRegionEditor(e){try{new Ti(e,To.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),To.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ai;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new N({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new ve({semtype:s.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new We}static fastaSequenceCellRenderer(){return new We}static separatorSequenceCellRenderer(){return new We}static bilnSequenceCellRenderer(){return new We}static refineNotationProviderForBiln(e,t,n){if("-"!==n)return!1;if(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))){const e=Object.keys(t.freq).filter(e=>e.startsWith("[")),n=Object.keys(t.freq).filter(e=>e.endsWith("]"));if(Object.keys(t.freq).filter(e=>(e.includes("[")||e.includes("]"))&&!e.startsWith("[")&&!e.endsWith("]")).length>0||0==e.length||0==n.length)return!1;if(Object.keys(t.freq).some(e=>e.startsWith("*")||e.startsWith("$")||e.startsWith("@")||e.startsWith("%")))return!1}return e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ue.Hi.BILN,e.temp[Le.j.notationProvider]=new go(n,To.seqHelper,e),!0}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===s.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=To.properties?To.properties.maxMonomerLength:4;if(Ne.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Ne.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=r.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=To.properties?To.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const a=r.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=ke.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),u=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),h=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==ue.Hi.HELM&&(d=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const m=[a,i,l,u,c,h];d&&m.push(d);const p=r.inputs(m);return new s.Widget(p)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ue.gp.alphabet],a=o===ue.YI.DNA||o===ue.YI.RNA?De.o.NUCLEOTIDE:De.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};ee().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);a===De.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,$e.MD)(n)}});const m=(0,gi.F)(l,a,t,Object.keys(d).length?d:void 0);return Array.from(m.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(m),new s.Widget(i)}(e,To.monomerLib,To.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ye}static sequenceAlignment(e,t,n,i,o){const r=new lt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new et.oP}static vdRegionsViewer(){return new rt}static getRegion(e,t,n,i){return wi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,r){const s=wi(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,c,u,h,d,m){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ii.V)(t,"Activity Cliffs"))return;const p=Ee(e),g={units:t.meta.units,aligned:t.getTag(ue.gp.aligned),separator:t.getTag(ue.gp.separator),alphabet:t.getTag(ue.gp.alphabet)},f=u,y=t,b=async()=>await le(e,y,p,"Activity cliffs",n,i,f,c,{...d??{}},s.SEMTYPE.MACROMOLECULE,g,h,ht,dt,ft,void 0,m),w=c===l.c.UMAP?2e5:2e4,v=c===l.c.UMAP?5e3:2e3;if(e.rowCount>w)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${w}`);const C=s.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),T=await new Promise((t,n)=>{e.rowCount>v&&!d?.[a.vb]?r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,be.AP)(e);throw To.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return T?.props?.xColumnName&&T?.props?.yColumnName&&e.col(T.props.xColumnName)&&e.col(T.props.yColumnName)&&(e.col(T.props.xColumnName).set(0,e.col(T.props.xColumnName).get(0)),e.col(T.props.yColumnName).set(0,e.col(T.props.yColumnName).get(0))),T}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==s.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:a}=await ct(e,t,o,n,i);return{entries:r,options:a}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ut.BQ)(e,To.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=G.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,r,l,c,u,h){if(e.name!==o.shell.tv.dataFrame.name)return void o.shell.error(`Table ${e.name} is not a current table view`);const d=o.shell.tv.dataFrame==e?o.shell.tv:void 0;return(0,ii.V)(t,"Sequence Space")?(l||(l=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await Me(e,[t],n,[i],[1],[l],"MANHATTAN",r,u??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[a.vb],tableView:d})):void 0}static async moleculesToHelmTopMenu(e,t){const n=To.monomerLib,i=JSON.stringify(n.toJSON());await yo.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==s.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=ue.Hi.HELM,o.semType=s.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async moleculeToHelmSingle(e){const t=s.Column.fromStrings("molecule",[e]);t.semType=s.SEMTYPE.MOLECULE;const n=s.DataFrame.fromColumns([t]);await Eo.moleculesToHelmTopMenu(n,t);const i=n.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence"))?.get(0);return i??""}static async toAtomicLevel(e,t,n=!0,i=!1){const o=s.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ao;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??To.monomerLib,r=To.seqHelper,s=To.rdKitModule;await(0,Ai.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=s.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Xi(e);if(t.errorText||!t.mol)return s.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=s.SemanticValue.fromValueType(t.mol,s.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=s.Widget.fromRoot(n.root));const a=o.chem.drawMolecule(t.mol,300,300,!1);return a.style.cursor="pointer",r.tooltip.bind(a,"Click to expand"),a.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=o.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(a),i??s.Widget.fromRoot(a)}catch(e){To.logger.error(e)}return s.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async toAtomicLevelSingleSeq(e){const t=e.includes("$$"),n=e.split("").filter(e=>"/"==e).length>2,i=e.split("").filter(e=>"-"==e).length>2,o=s.Column.fromStrings("sequence",[e]);o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=t?ue.Hi.HELM:n?ue.Hi.SEPARATOR:i?ue.Hi.BILN:ue.Hi.FASTA,o.setTag(ue.gp.aligned,"SEQ"),n&&o.setTag(ue.gp.separator,"/"),i&&o.setTag(ue.gp.separator,"-");const r=e.split("").every(e=>"AGCT".includes(e)||"/"===e||"-"===e),a=!r&&e.split("").every(e=>"AGCU".includes(e)||"/"===e||"-"===e);o.setTag(ue.gp.alphabet,r?ue.YI.DNA:a?ue.YI.RNA:"UN"),o.setTag(ue.gp.alphabetIsMultichar,"true");const l=s.DataFrame.fromColumns([o]).cell(0,"sequence"),c=s.SemanticValue.fromTableCell(l),u=await Xi(c);if(u.errorText||!u.mol)throw new Error(u.errorText);return u.mol}static async sequence3dStructureWidget(e){return async function(e){const t=s.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(s.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const a=await Xi(e);if(a.errorText||!a.mol)return n=r.divText(a.errorText??"No structure generated"),t.close(),new s.Widget(n);const l=a.mol;i=await o.functions.call("Bio:Embed",{molecule:l});const c=xi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new s.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,ri.D)({},To.seqHelper).catch(e=>{const[t,n]=(0,be.AP)(e);if(e instanceof oi.Ap)return o.shell.warning(e.element),void To.logger.warning(t);o.shell.error(t),To.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,ri.D)({col:e,clustersCol:t,...n},To.seqHelper)}static async compositionAnalysis(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==s.SEMTYPE.MACROMOLECULE&&(To.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,ii.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,s.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>To.seqHelper.getSeqHandler(e).isMsa()),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}static importFasta(e){return new he.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,_e.me)()[0];(0,At.C)(e,To.seqHelper)}static convertColumnAction(e){(0,At.C)(e,To.seqHelper)}static monomerCellRenderer(){return new hi}static async testDetectMacromolecule(e){const t=s.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const r=[];for(const a of n)try{const t=await o.dapi.files.readAsText(e+a.fullPath),n=s.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===s.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:a.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${a.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const a=s.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${e}`,a}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Ze.cb)(10),!(0,ii.V)(t,"Sequence space"))return e;const n=me(t,To.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Be.uF.MONOMER,e.setTag(ge.gp.alphabet,t.getTag(ge.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,a=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Be.uF.MONOMER,o.setTag(ge.gp.alphabet,t.getTag(ge.gp.alphabet));const r=100;let s=0;for(;i.columns.byName(o.name)&&s<r;)o.name=a(o.name),s++;i.columns.add(o)}await o.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(s.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return To.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new vt(To.seqHelper)}static similaritySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Ct(To.seqHelper)}static diversitySearchTopMenu(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,_e.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,To.seqHelper)}static SubsequenceSearchTopMenu(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=To.seqHelper;return Ei(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=To.seqHelper;return Ei(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Yn()}static async manageLibrariesView(){await jn()}static async manageMonomersView(){const e=await nn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await jn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await kn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await nn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,Et.TE)()}static bioSubstructureFilter(){return new St._i(To.seqHelper,To.logger)}static bioSubstructureFilterTest(){return new St._i(To.seqHelper,To.logger)}static async webLogoLargeApp(){const e=s.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new si(e,"webLogoLargeApp"),n=await To.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=s.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new si(e,"webLogoAggApp"),n=await To.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Ci(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=s.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await To.files.readCsv("samples/HELM_empty_vals.csv"),n=new Ci(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=s.DataFrame.fromColumns((0,xe.dW)());o.shell.addTableView(e)}static longSeqTableFasta(){const e=s.DataFrame.fromColumns([(0,xe.Hx)(To.seqHelper,ue.Hi.FASTA)]);o.shell.addTableView(e)}static longSeqTableHelm(){const e=s.DataFrame.fromColumns([(0,xe.Hx)(To.seqHelper,ue.Hi.HELM)]);o.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ue.Hi).filter(e=>e!==ue.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,r=e.rowIndex,s=n.getSeqHandler(i),a=t===ue.Hi.SEPARATOR?To.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,To.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await To.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,s.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,_e.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,s.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await To.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=s.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Eo.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,l.c.UMAP,ce.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await s.delay(100),Gn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await s.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===s.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,s.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,s.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),To.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await To.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await Eo.toAtomicLevel(e,n,!0,!1),(0,_e.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,_e.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(de.Ec).forEach(t=>{if("symbol"===t){const o=e.get(de.Ec[t],n);i[t]="."===o?e.get(de.yw,n):o}else if("rgroups"===t){const o=e.get(de.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else de.Ec[t]&&(i[t]=e.get(de.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);s.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){return e.trim()?Eo.toAtomicLevelSingleSeq(e):""}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=s.Column.fromList(s.COLUMN_TYPE.STRING,"seq",[e]),i=s.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await Ei(i,n,t,pe.IDENTITY,To.seqHelper)).get(0)}catch(e){const[t,n]=(0,be.AP)(e);throw To.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=s.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const a=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=s.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==s.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${a.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Ze.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Eo.initBio(),To.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=To.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,To.rdKitModule,i);return r.semType=s.SEMTYPE.MOLECULE,r}(0,t,n,To.monomerLib)}}wo([o.decorators.func({description:"Returns an instance of the monomer library 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h=n(4870);const d="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,h.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then(()=>{setTimeout(()=>{this.grid.cell(d,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))},100)})}updateInputs(){const e=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,h.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",()=>this.editHelmLinkAction(),void 0,{style:{position:"relative",left:"95px"}});const t=r.DataFrame.create(1);t.columns.addNewString(d).init(e=>""),t.col(d).semType=this.col.semType,t.col(d).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK(async()=>{let e,n=this.units===a.Hi.HELM?t.get(d,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await g(n,this.col,this.seqHelper):p(n,this.col),this.col.dataFrame.filter.and(e)}).show()}}function p(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,r=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(e,n):e,o=r.BitSet.create(t.length);for(let n=0;n<t.length;n++){const r=t.get(n);(r.match(i)||r===e)&&o.set(n,!0,!1)}return o}async function g(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await f(t,n,!0);const o=r.Column.string("helm",1).init(t=>e);o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await c(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function f(e,t,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,s.cb)(10);const i=new Map,o=await c(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966(e,t,n){"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(4567);function s(e,t,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,u]=a(e,t,l,n,o);return s&&!c&&i.shell.warning(u),c}function a(e,t,n,r=[],s=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(r.length>0&&!r.some(e=>o.toUpperCase()==e.toUpperCase()))l=`${t} + ' analysis is allowed for Macromolecules with notation 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l,c;!function(e){e.CELL_CHANGING="isCellChanging"}(l||(l={})),function(e){e.SEPARATOR="."}(c||(c={}));const u="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:s.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433(e,t,n){"use strict";n.d(t,{C:()=>d,r:()=>m});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(2738);let u=null,h=[];async function d(e,t){let n=e??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),d=s.notation;const p=o.divText("Current notation: "+d,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),g=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM,l.Hi.BILN],f=await c.$G.getProviderConstructors(),y=o.input.column("Column",{table:r.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),d=s.notation,d===l.Hi.HELM&&(v.value="/"),p.textContent="Current notation: 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m(n,t,e,i,o)}).show({x:350,y:100}),h.push(u.onClose.subscribe(e=>{h.forEach(e=>{e.unsubscribe()}),h=[],u=null})))}async function m(e,t,n,o,s){if(s){const t=e.dataFrame.columns.getUnusedName(`${s.notationName}(${e.name})`),n=i.Column.string(t,e.length);n.init(t=>{const n=e.get(t);try{return s.convertFromHelm(n,{})}catch(e){return console.error(`Error converting sequence at row ${t}: ${e instanceof Error?e.message:e}`),""}}),e.dataFrame.columns.add(n);const o=await r.functions.call("Bio:detectMacromolecule",{col:n});return o&&(n.semType=o),await r.data.detectSemanticTypes(e.dataFrame),n}{const i=t.getSeqHandler(e).convert(n,o);e.dataFrame.columns.add(i);const s=await r.functions.call("Bio:detectMacromolecule",{col:i});return s&&(i.semType=s),await r.data.detectSemanticTypes(e.dataFrame),i}}},6956(e,t,n){"use strict";n.d(t,{m:()=>o,x:()=>i});const i="|",o="H"},2582(e,t,n){"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.x).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA|CHEM|BLOB)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA|CHEM|BLOB)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=e.indexOf("}$"),n=e.substring(0,t+1),i=e.indexOf("$",t+2),r=e.substring(t+2,i),a=n.split("}|");for(let e=0;e<a.length-1;e++)a[e]=a[e]+"}";this.simplePolymers=a.map(e=>new s(e)),this.connectionList=new o(r),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>t-e).find(t=>e>=t);if(null==n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},8604(e,t,n){"use strict";n.d(t,{G:()=>i,V:()=>o});const i={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}},o={PEPTIDE:334,RNA:383,CHEM:0}},1619(e,t,n){"use strict";n.d(t,{D:()=>x});var i=n(4328),o=n(6082),r=n(7389),s=n(5749),a=n(2003),l=n(608),c=n(8152),u=n(966),h=n(4139),d=n(5072),m=n.n(d),p=n(7825),g=n.n(p),f=n(7659),y=n.n(f),b=n(5056),w=n.n(b),v=n(540),C=n.n(v),T=n(1113),A=n.n(T),E=n(6369),S={};S.styleTagTransform=A(),S.setAttributes=w(),S.insert=y().bind(null,"head"),S.domAPI=g(),S.insertStyleElement=C(),m()(E.A,S),E.A&&E.A.locals&&E.A.locals;var M=n(4567);async function x(e,t){return new Promise(async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const u=e.col?.dataFrame??i.shell.t;if(!u){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const d=e.col??u.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const m=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});m.setTooltip("Alignment method");const p=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${h.b9}`,"kalign-version"),f=r.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),w=r.inputs([f,y,p]),v=r.button("Alignment parameters",()=>{w.hidden=!w.hidden,[f,y,p].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");v.classList.add("msa-params-button"),w.hidden=!0,v.prepend(r.icons.settings(()=>null));const C=[m.root.style],T=[p.root.style,g.style];let A,E=d;const S=r.input.column("Sequence",{table:u,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(S.value=E);E=e,L.disabled=!1,A=await I(S.value,u,t,C,T,m,M,f,y,p,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});S.setTooltip("Sequences column to use for alignment");const M=r.input.column("Clusters",{table:u,value:e.clustersCol});M.nullable=!0;const x=r.dialog("MSA").add(S).add(M).add(m).add(w).add(v).add(b).add(g).onOK(async()=>{await P(S,u,A,n,a)}),L=x.getButton("OK");if(S.fireChanged(),e.col)return A=await I(e.col,u,t,C,T,m,M,f,y,p,b),void await P(S,u,A,n,a);x.show()})}async function P(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA 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e.reduce((e,t,n)=>e+`>sample${n+1}\n${t}\n`,"")}async function F(e,t,n=!1,i="",r=null,s,c,u,h){let d=t.toList();n&&(d=d.map(e=>R.clean(e).replace(/\-/g,"")));const m=t.length;r??=o.Column.string("Clusters",m).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const p=r.categories,g=r.getRawData(),f=new Array(p.length),y=new Array(p.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<m;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}B(y,p);const b=await new L(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),w=o.Column.string(i,m);for(let e=0;e<p.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=k(t);await b.fs.writeFile(O,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta 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c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,p,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,w=d.getRawData(),v=new Array(b.length),C=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(C[n]??=[]).push(e))}(0,s.aZ)(C,b);const T=new Array(y).fill(null);for(const e of v){if(!e||0===e.length)continue;const t=(await m(f.id,e,i,l,u,p)).Alignment;for(const e of t)T[parseInt(e.ID)]=Object.entries(e).filter(e=>!h.includes(e[0])).map(e=>"-"!==e[1]?e[1]:"").join(a.J.SEPARATOR)}const A=o.Column.fromStrings(n,T);return A.meta.units=r.Hi.SEPARATOR,A.setTag(r.gp.separator,a.J.SEPARATOR),A.setTag(r.gp.aligned,"SEQ.MSA"),A.setTag(r.gp.alphabet,r.YI.UN),A.setTag(r.gp.alphabetIsMultichar,"true"),A.semType=o.SEMTYPE.MACROMOLECULE,A}async function m(e,t,n,o,r,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${r}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const m="application/json"===h.headers.get("content-type");if(!h.ok&&m){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!m){const e=await h.text();throw new Error(`Error: ${e}`)}if(!m){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const p=await h.json();if("pepsea-stderr"in p){const e=p["pepsea-stderr"];s?.warning(e)}return p}},3890(e,t,n){"use strict";n.d(t,{TE:()=>c,aS:()=>h,wz:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1991),a=n.n(s),l=n(4567);function c(){const e=r.shell.tv.grid,t=e.dataFrame,n=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>e.semType!==i.SEMTYPE.MACROMOLECULE).toArray().find(e=>-1!==e.name.toLowerCase().indexOf("id")),s=n?[n]:[],c=o.input.columns("Seq id columns",{table:t,value:s,filter:e=>e.semType!==i.SEMTYPE.MACROMOLECULE}),h=a().count(0).take(t.columns.length).map(e=>t.columns.byIndex(e)).filter(e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()).toArray(),d=h.length>0?h[0]:null,m=o.input.column("Seq column",{table:t,value:d,filter:e=>!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()}),p=o.input.int("FASTA line width",{value:60});o.dialog({title:"Save as FASTA"}).add(o.inputs([c,m,p])).onOK(()=>{const t=c.value??[],n=m.value??null,i=p.value??60;n||r.shell.warning("Seq column is mandatory to save as FASTA.");const o=u(t,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(o)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()}).show()}function u(e,t,n=60,i="\n"){const o=[];for(let r=0;r<t.length;r++){const s=e.map(e=>e.get(r).toString()).join("|"),a=h(t.getSplitted(r),n);o.push(`>${s}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}function h(e,t=60){let n=0;const i=e.length,o=[];for(;n<i;){const i=a().count(n).take(Math.min(e.length-n,t)).map(t=>e.getOriginal(t)).toArray(),r=i.map(e=>e.length>1?`[${e}]`:e).reduce((e,t)=>e+t,"");o.push(r),n+=i.length}return o}},8754(e,t,n){"use strict";n.d(t,{V:()=>u});var i=n(4328),o=n(6077),r=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function u(e,t,n,u,h,d,m){let p;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let o,a;i.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=i.convert(r.Hi.HELM),o.name=a,e.columns.add(o,!1));try{p=await n.helmToAtomicLevel(o,!0,!0,h)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};p=await(0,o.C4)(e,t,h,d,m)}if(p.molCol){const o=(0,c.qj)(e,t.name);p.molCol.name=o,e.columns.add(p.molCol,!0),await(0,a.Qc)(t,p.molCol,h,d,m,n),p.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await i.data.detectSemanticTypes(e)}return p}},4870(e,t,n){"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>r});var i=n(4328),o=n(6082);function r(){const e=i.shell.t.columns.bySemTypeAll(o.SEMTYPE.MACROMOLECULE);return null==e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function s(e,t){e.innerHTML="",e.append(t)}function a(e,t,n,i,o){const r=()=>{const o=e.col(t);o&&(o.width=n),i&&(e.props.rowHeight=i)};if(o)return void r();const s=e.onAfterDrawOverlay.subscribe(()=>{s.unsubscribe(),setTimeout(()=>{r()})})}},250(e,t,n){"use strict";n.d(t,{VN:()=>P,n5:()=>C,Ue:()=>S,Tc:()=>E,oP:()=>I,eN:()=>L});var i=n(4328),o=n(7389),r=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(2003),d=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var p=n(5749),g=n(7602),f=n(439),y=n(6882);var b=n(4567);function w(e,t,n){return Math.abs(e-t)<=n}var v,C,T=n(6307),A=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class E{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new E),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const m=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of m){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const u=l.bounds,d=u.left;let p=y.S$;if(r)try{p=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,A.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){m(e)}const g=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(u.width/f.width,0,0,u.height/i,d,u.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,T.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(v||(v={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var x;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(x||(x={}));const P=new class{render=20};class I extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:v.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:v.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:v.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:v.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:v.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:v.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:v.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:v.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:v.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:v.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:v.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:v.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:v.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:v.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:v.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:v.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:v.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:v.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:v.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:v.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:v.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:v.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(x.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(x.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,P.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(x.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(x.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(x.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){w(e,this.slider.minRange,.1)&&w(t,this.slider.maxRange,.1)&&w(n,this.slider.min,.1)&&w(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(x.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(x.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(x.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=x.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=x.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(h.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(h.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=x.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],h=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=x.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;w(n,this.positionWidth,.1)?this.render(x.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(x.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(x.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(x.None,t),this.viewSyncer.sync(`${n}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,p.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function L(e,t,n,i,o){let r=0,s=-1;for(;-1!=(s=n.findNext(s,!0));){const e=t.getSplitted(s),n=o.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===i&&r++}return r}},1687(e,t,n){"use strict";n.d(t,{_i:()=>E,AR:()=>A});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(5749),h=n(7602),d=n(4954),m=n(4574),p=n(1757),g=n.n(p),f=n(9124),y=n(9192),b=n(4870),w=n(4567);class v extends m.O{seqHelper;emptyProps=new m.n("",void 0,w._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e,void 0,w._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class T{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends m.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class E extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter?.filterSummary??""}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++E.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{e&&await e.meta.detectSemanticTypes(),t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new S:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&this.bioFilter&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),this.bioFilter&&(t.props=this.bioFilter.saveProps()),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),this.bioFilter&&r.events.fireCustomEvent(C,new T(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${this.bioFilter?JSON.stringify(this.bioFilter?.saveProps()):"null"}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class S extends m.O{emptyProps=new m.n("",void 0,w._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new m.n(e,void 0,w._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new A("",void 0,w._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new A(e,this.props.separator,w._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new A(this.props.substructure,t,w._package.logger),setTimeout(()=>{this._propsChanging||this.onChanged.next()})},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new A("",void 0,w._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757(e){"use strict";e.exports=$},6082(e){"use strict";e.exports=DG},4328(e){"use strict";e.exports=grok},1858(e){"use strict";e.exports=rxjs},9713(e){"use strict";e.exports=rxjs.operators},7389(e){"use strict";e.exports=ui},1991(e){"use strict";e.exports=wu},8343(e,t,n){"use strict";const{normalizeIPv6:i,removeDotSegments:o,recomposeAuthority:r,normalizeComponentEncoding:s,isIPv4:a,nonSimpleDomain:l}=n(4834),{SCHEMES:c,getSchemeHandler:u}=n(343);function h(e,t,n,i){const r={};return i||(e=p(d(e,n),n),t=p(d(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(r.scheme=t.scheme,r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(t.path?("/"===t.path[0]?r.path=o(t.path):(void 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i=n?Object.assign({scheme:"null"},n):{scheme:"null"},o=h(p(e,i),p(t,i),i,!0);return i.skipEscape=!0,d(o,i)},resolveComponent:h,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=d(s(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=d(s(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=d(s(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=d(s(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:d,parse:p};e.exports=g,e.exports.default=g,e.exports.fastUri=g},343(e,t,n){"use strict";const{isUUID:i}=n(4834),o=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu,r=["http","https","ws","wss","urn","urn:uuid"];function s(e){return!0===e.secure||!1!==e.secure&&!!e.scheme&&!(3!==e.scheme.length||"w"!==e.scheme[0]&&"W"!==e.scheme[0]||"s"!==e.scheme[1]&&"S"!==e.scheme[1]||"s"!==e.scheme[2]&&"S"!==e.scheme[2])}function a(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function l(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const c={scheme:"http",domainHost:!0,parse:a,serialize:l},u={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=s(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(s(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},h={http:c,https:{scheme:"https",domainHost:c.domainHost,parse:a,serialize:l},ws:u,wss:{scheme:"wss",domainHost:u.domainHost,parse:u.parse,serialize:u.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const n=e.path.match(o);if(n){const i=t.scheme||e.scheme||"urn";e.nid=n[1].toLowerCase(),e.nss=n[2];const 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${o}`)}}const w=[{name:"Valid Biln",seqs:["A-C(1,3)-G-G-H-A-V-E-A-K-Y-L-V-C(3,3)-S.G-I-V-E-A-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-Y","A-C(1,3)-G-G-H-A-V-E-A-K-Y-L-V-C(3,3)-S.G-I-V-E-A-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-Y","C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.C(1,1)(2,2)(3,3)","C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.[C](1,1)(2,2)(3,3)","D-T-H-F-P-I-C(1,3)-I-F-C(2,3)-C(3,3)-G-C(2,3)-C(4,3)-H-R-S-K-C(3,3)-G-M-C(4,3)-C(1,3)-K-T"],negative:!1},{name:"Simple Separator Neg",seqs:["meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me","Lys_Boc/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Thr_PO3H2/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Thr_PO3H2/N/D-Orn/D-aThr//Phe_4Me","meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"],negative:!0},{name:"Valid Biln without cyclization",seqs:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-Tyr_Bn-dV-E-N-dV---Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-Aze-dV-E-N-dV---Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-meQ-dV-E-N-dV---Phe_4Me"],negative:!1}],v=[{name:"Linear",biln:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me"],helm:["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].[Chg].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$"]},{name:"Cyclic",biln:["C-C(1,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(3,3)-NH2.[C](1,1)(2,2)(3,3)","D-T-H-F-P-I-C(1,3)-I-F-C(2,3)-C(3,3)-G-C(2,3)-C(4,3)-H-R-S-K-C(3,3)-G-M-C(4,3)-C(1,3)-K-T","L-C(1,3)-G-S-H-L-V-E-A-L-Y-L-V-C(2,3)-G.G-I-V-E-Q-C(3,3)-C(1,3)-T-S-I-C(3,3)-S-L-Y-Q-L-E-N-Y-C(2,3)-N","H-Aib-E-G-T-F-T-S-D(2,3)-V-S-S-Y-L-E-G-Q-A-A-K(1,3)-E-F-I-A-W-L-V-R-G-R-G.C(2,3)-gGlu-G-G(1,2)","F(4,2).dI(1,1)(3,3)-Trp_Ome-Asp_OMe-Cys_Bn-meG-Phe_3Cl-dD-T-dI(4,3)-T-dK-aG-3Pal-xiIle-meD-Ala_tBu(1,2).L(2,1)-Pro_4Me3OH-S-NMe2Abz-Q-3Pal-xiIle-D-Hyp-Ala_tBu-dI(3,3)-Trp_Ome-Asp_OMe-N-meG-Phe_34diCl-Phe_34diCl(2,2)"],helm:["PEPTIDE1{C.C.S.W.P.A.R.C.L.H.Q.D.L.C.[NH2]}|PEPTIDE2{C}$PEPTIDE1,PEPTIDE2,14:R3-1:R3|PEPTIDE1,PEPTIDE2,8:R3-1:R2|PEPTIDE1,PEPTIDE2,2:R3-1:R1$$$V2.0","PEPTIDE1{D.T.H.F.P.I.C.I.F.C.C.G.C.C.H.R.S.K.C.G.M.C.C.K.T}$PEPTIDE1,PEPTIDE1,10:R3-13:R3|PEPTIDE1,PEPTIDE1,11:R3-19:R3|PEPTIDE1,PEPTIDE1,14:R3-22:R3|PEPTIDE1,PEPTIDE1,7:R3-23:R3$$$V2.0","PEPTIDE1{L.C.G.S.H.L.V.E.A.L.Y.L.V.C.G}|PEPTIDE2{G.I.V.E.Q.C.C.T.S.I.C.S.L.Y.Q.L.E.N.Y.C.N}$PEPTIDE1,PEPTIDE2,2:R3-7:R3|PEPTIDE2,PEPTIDE2,6:R3-11:R3|PEPTIDE1,PEPTIDE2,14:R3-20:R3$$$V2.0","PEPTIDE1{H.[Aib].E.G.T.F.T.S.D.V.S.S.Y.L.E.G.Q.A.A.K.E.F.I.A.W.L.V.R.G.R.G}|PEPTIDE2{C.[gGlu].G.G}$PEPTIDE1,PEPTIDE2,9:R3-1:R3|PEPTIDE1,PEPTIDE2,20:R3-4:R2$$$V2.0","PEPTIDE1{F}|PEPTIDE2{[dI].[Trp_Ome].[Asp_OMe].[Cys_Bn].[meG].[Phe_3Cl].[dD].T.[dI].T.[dK].[aG].[3Pal].[xiIle].[meD].[Ala_tBu]}|PEPTIDE3{L.[Pro_4Me3OH].S.[NMe2Abz].Q.[3Pal].[xiIle].D.[Hyp].[Ala_tBu].[dI].[Trp_Ome].[Asp_OMe].N.[meG].[Phe_34diCl].[Phe_34diCl]}$PEPTIDE1,PEPTIDE2,1:R2-9:R3|PEPTIDE2,PEPTIDE2,1:R1-16:R2|PEPTIDE2,PEPTIDE3,1:R3-11:R3|PEPTIDE3,PEPTIDE3,1:R1-17:R2$$$V2.0"]}],C=[{name:"Linear",biln:["meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-E-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-[Phe_ab-dehydro]-N-[D-Orn]-[D-aThr]--Phe_4Me","Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-[D-Chg]-dV-Thr_PO3H2-N-[D-Orn]-[D-aThr]--Phe_4Me","meI-hHis-Aca-N-T-dK-Thr_PO3H2-Aca-[D-Tyr_Et]-[Tyr_ab-dehydroMe]-dV-Chg-N-[D-Orn]-[D-aThr]--Phe_4Me"],helm:["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Thr_PO3H2].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$","PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].[Chg].N.[D-Orn].[D-aThr].*.[Phe_4Me]}$$$$"]},{name:"Cyclic",biln:["C-C(3,3)-S-W-P-A-R-C(2,3)-L-H-Q-D-L-C(1,3)-NH2.C(1,3)(2,2)(3,1)","D-T-H-F-P-I-C(4,3)-I-F-C(1,3)-C(2,3)-G-C(1,3)-C(3,3)-H-R-S-K-C(2,3)-G-M-C(3,3)-C(4,3)-K-T","L-C(1,3)-G-S-H-L-V-E-A-L-Y-L-V-C(3,3)-G.G-I-V-E-Q-C(2,3)-C(1,3)-T-S-I-C(2,3)-S-L-Y-Q-L-E-N-Y-C(3,3)-N","H-Aib-E-G-T-F-T-S-D(1,3)-V-S-S-Y-L-E-G-Q-A-A-K(2,3)-E-F-I-A-W-L-V-R-G-R-G.C(1,3)-gGlu-G-G(2,2)","F(1,2).dI(2,1)(3,3)-Trp_Ome-Asp_OMe-Cys_Bn-meG-Phe_3Cl-dD-T-dI(1,3)-T-dK-aG-3Pal-xiIle-meD-Ala_tBu(2,2).L(4,1)-Pro_4Me3OH-S-NMe2Abz-Q-3Pal-xiIle-D-Hyp-Ala_tBu-dI(3,3)-Trp_Ome-Asp_OMe-N-meG-Phe_34diCl-Phe_34diCl(4,2)"],helm:["PEPTIDE1{C.C.S.W.P.A.R.C.L.H.Q.D.L.C.[NH2]}|PEPTIDE2{C}$PEPTIDE1,PEPTIDE2,14:R3-1:R3|PEPTIDE1,PEPTIDE2,8:R3-1:R2|PEPTIDE1,PEPTIDE2,2:R3-1:R1$$$V2.0","PEPTIDE1{D.T.H.F.P.I.C.I.F.C.C.G.C.C.H.R.S.K.C.G.M.C.C.K.T}$PEPTIDE1,PEPTIDE1,10:R3-13:R3|PEPTIDE1,PEPTIDE1,11:R3-19:R3|PEPTIDE1,PEPTIDE1,14:R3-22:R3|PEPTIDE1,PEPTIDE1,7:R3-23:R3$$$V2.0","PEPTIDE1{L.C.G.S.H.L.V.E.A.L.Y.L.V.C.G}|PEPTIDE2{G.I.V.E.Q.C.C.T.S.I.C.S.L.Y.Q.L.E.N.Y.C.N}$PEPTIDE1,PEPTIDE2,2:R3-7:R3|PEPTIDE2,PEPTIDE2,6:R3-11:R3|PEPTIDE1,PEPTIDE2,14:R3-20:R3$$$V2.0","PEPTIDE1{H.[Aib].E.G.T.F.T.S.D.V.S.S.Y.L.E.G.Q.A.A.K.E.F.I.A.W.L.V.R.G.R.G}|PEPTIDE2{C.[gGlu].G.G}$PEPTIDE1,PEPTIDE2,9:R3-1:R3|PEPTIDE1,PEPTIDE2,20:R3-4:R2$$$V2.0","PEPTIDE1{F}|PEPTIDE2{[dI].[Trp_Ome].[Asp_OMe].[Cys_Bn].[meG].[Phe_3Cl].[dD].T.[dI].T.[dK].[aG].[3Pal].[xiIle].[meD].[Ala_tBu]}|PEPTIDE3{L.[Pro_4Me3OH].S.[NMe2Abz].Q.[3Pal].[xiIle].D.[Hyp].[Ala_tBu].[dI].[Trp_Ome].[Asp_OMe].N.[meG].[Phe_34diCl].[Phe_34diCl]}$PEPTIDE1,PEPTIDE2,1:R2-9:R3|PEPTIDE2,PEPTIDE2,1:R1-16:R2|PEPTIDE2,PEPTIDE3,1:R3-11:R3|PEPTIDE3,PEPTIDE3,1:R1-17:R2$$$V2.0"]}];async function T(t){const n=e.Column.fromList(e.TYPE.STRING,"col1",t);if(await l.functions.call("Bio:detectMacromolecule",{col:n}),n.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${n.semType}', units='${n.meta.units}'.`;throw new Error(e)}}async function A(n,i,o,r,s,a,u,h=null){const d=e.Column.fromList(e.TYPE.STRING,"seq",n),m=await l.functions.call("Bio:detectMacromolecule",{col:d});m&&(d.semType=m),(0,t.E3)(d.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(d.meta.units,o),(0,t.E3)(d.getTag(c.gp.aligned),r),(0,t.E3)(d.getTag(c.gp.alphabet),s),h&&(0,t.E3)(d.getTag(c.gp.separator),h);const p=i.getSeqHandler(d);(0,t.E3)(p.getAlphabetSize(),a),(0,t.E3)(p.getAlphabetIsMultichar(),u),p.isHelm()||((0,t.E3)(p.aligned,r),(0,t.E3)(p.alphabet,s))}async function E(e,t,n){const i=await e(),o=[];for(const r of i.columns.names())if(r in t){const i=t[r];try{await m(e,r,n,i.units,i.aligned,i.alphabet,i.alphabetSize,i.alphabetIsMultichar,i.separator)}catch(e){const t=e.toString();o.push(`Positive col '${r}' failed: ${t}`)}}else try{await d(e,r)}catch(e){const t=e.toString();o.push(`Negative col '${r}' failed: ${t}`)}if(o.length>0)throw new Error(o.join("\n"))}(0,t.L1)("detectors",()=>{let n;(0,t.gM)(async()=>{n=await(0,u.Q)()});const i={negEmpty:{csv:"id,col1\n1,\n2,\n3,\n4,\n5,",neg:["col1"]},negNum1:{csv:"col1\n1\n2\n3",neg:["col1"]},negNum2:{csv:"col1\n4\n5\n6\n7",neg:["col1"]},negNum3:{csv:"col1\n8\n9\n10\n11\n12",neg:["col1"]},negSmiles:{csv:"col1\nCCCCN1C(=O)CN=C(c2cc(F)ccc12)C3CCCCC3\nC1CCCCC1\nCCCCCC",neg:["col1"]},negSmilesWithSquareBrackets:{csv:"col1\nCl.c1ccc2nc3ccccc3cc2c1\nOc1cccc2cc3ccccc3cc12\n[SeH]c1ccc2ccccc2c1",neg:["col1"]},negFastaUnSingleChar:{csv:"col1\nAlanine\nCysteine\nAspartic acid\nGlutamic acid\nPhenylalanine",neg:["col1"]},fastaMsaSameLength:{csv:"seq\nFWPHEYFWPHEYYV\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1,void 0)}},fastaExtSameLength:{csv:"seq\nFW[Ac]PHEYFWPH\nYN[Re]VYNRQWYV\n[Me]EYVMPS[Et]",pos:{seq:new h(c.Hi.FASTA,"SEQ",c.YI.UN,16,!0,void 0)}},fastaMsaExtSameLength:{csv:"seq\nFW[Ac]PHEY[Re]WPH\nYN[Re]VYNR[Ac]WYV\n[Me]EYVMPSFW[Me]H",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.UN,14,!0,void 0)}},fastaMsaExtManyMinus:{csv:"seq\n[D-Tic]-------[D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]N[D-Orn][D-aThr]-[Phe_4Me]\n[Phe_2F]--------[Tyr_ab-dehydroMe][dV][Aca]N[D-Orn][D-aThr]-[Phe_4Me]\n[D-Tic]-[Hcy]QTWQ[Phe_4NH2][D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]----[Phe_4Me]",pos:{seq:new h(c.Hi.FASTA,"SEQ.MSA",c.YI.UN,17,!0,void 0)}},sepSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2",pos:{seq:new h(c.Hi.SEPARATOR,"SEQ.MSA",c.YI.UN,5,!0,"-")}},sepMsaSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2\nAca-A-Aca-A-A-A-meI-A-A-A-A-A-Aca-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2",pos:{seq:new h(c.Hi.SEPARATOR,"SEQ",c.YI.UN,5,!0,"-")}},helmSameLength:{csv:"seq\nPEPTIDE1{Ac(1).A.A.A.A.A.A.A.A.A.A.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ab(1).Y.V.K.H.P.F.W.R.W.Y.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ad(1).S.W.Y.C.K.H.P.M.W.A.A.A.A.C(1)-G-NH2}$$$$",pos:{seq:new h(c.Hi.HELM,null,null,19,void 0,void 0)}},fastaNonDigitAlphabet:{csv:'flagC\n"NMe-pyridazineH"\n"Pyrrolo[2,3-c]pyridazineH"',neg:["flagC"]}};for(const[o,r]of Object.entries(i))(0,t.t6)(`csvData2-${o}`,async()=>{const t=(s=o,async()=>{const t=i[s].csv,n=e.DataFrame.fromCsv(t);return await l.data.detectSemanticTypes(n),n});var s;for(const e of r.neg??[])await d(t,e);for(const[e,i]of Object.entries(r.pos??{}))await m(t,e,n,i.units,i.aligned,i.alphabet,i.alphabetSize,i.alphabetIsMultichar,i.separator)});const o=new class{csvFastaDna1="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC";fastaRna1="seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC";fastaPt1="seq\nFWPHEY\nYNRQWYV\nMKPSEYV";fastaUn="seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]DN\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]";sepDna="seq\nA*C*G*T*C*A*C*G*T*C\nC*A*G*T*G*T*C*A*G*T*G*T\nT*T*C*A*A*C*T*T*C*A*A*C";sepRna="seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C";sepPt="seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V";sepUn1="seq\nabc-dfgg-abc1-cfr3-rty-wert-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-cfr3-wert-rut12";sepUn2="seq\nabc/dfgg/abc1/cfr3/rty/wert/abc/dfgg/abc1/cfr3/rty/wert\nrut12/her2/rty/wert//abc/abc1/dfgg/rut12/her2/rty/wert//abc/abc1/dfgg\nrut12/rty/her2/abc/cfr3//wert/rut12/rut12/rty/her2/abc/cfr3//wert/rut12";sepMsaDna1="seq\nA-C--G-T--C-T-A-C--G-T--C-T\nC-A-C--T--G-T-C-A-C--T--G-T\nA-C-C-G-T-A-C-T-A-C-C-G-T-A-C-T";sepMsaUnWEmpty="seq\nm1-M-m3-mon4-mon5-N-T-MON8-N9-m1-M-m3-mon4-mon5-N-T-MON8-N9\nm1-mon2-m3-mon4-mon5-Num--MON8-N9-m1-mon2-m3-mon4-mon5-Num--MON8-N9\n\nmon1-M-mon3-mon4-mon5---MON8-N9-mon1-M-mon3-mon4-mon5---MON8-N9";sepComplex="seq\nAca-F-K(AEEA-AEEA-R-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-ARRA-W-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-AEEA-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2";fastaMsaDna1="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT";fastaMsaPt1="seq\nFWR-WYV-KHPFWR-WYV-KHP\nYNR-WYV-KHPYNR-WYV-KHP\nMWRSWY-CKHPMWRSWY-CKHP"},r={fastaPtCsv:"System:AppData/Bio/samples/FASTA_PT.csv",msaComplex:"System:AppData/Bio/samples/MSA.csv",fastaCsv:"System:AppData/Bio/samples/FASTA.csv",helmCsv:"System:AppData/Bio/samples/HELM.csv",peptidesComplex:"System:AppData/Bio/tests/peptides_complex_msa.csv",peptidesSimple:"System:AppData/Bio/tests/peptides_simple_msa.csv",testDemogCsv:"System:AppData/Bio/tests/testDemog.csv",testHelmCsv:"System:AppData/Bio/tests/testHelm.csv",testIdCsv:"System:AppData/Bio/tests/testId.csv",testSmilesCsv:"System:AppData/Bio/tests/testSmiles.csv",testSmiles2Csv:"System:AppData/Bio/tests/testSmiles2.csv",testSmilesShort:"System:AppData/Bio/tests/testSmilesShort.csv",testActivityCliffsCsv:"System:AppData/Bio/tests/testActivityCliffs.csv",testCerealCsv:"System:AppData/Bio/tests/testCereal.csv",testUnichemSources:"System:AppData/Bio/tests/testUnichemSources.csv",testDmvOffices:"System:AppData/Bio/tests/testDmvOffices.csv",testAlertCollection:"System:AppData/Bio/tests/testAlertCollection.csv",testSpgi100:"System:AppData/Bio/tests/testSpgi100.csv",testSpgi:"System:AppData/Bio/tests/SPGI-derived.csv",testUrl:"System:AppData/Bio/tests/testUrl.csv",fasta_negative_words:"System:AppData/Bio/tests/fasta_negative_words.csv"},s={};function a(e,t=p){return async()=>(e in s||(s[e]=(async()=>await t(r[e]))().catch(t=>{throw delete s[e],t})),s[e])}async function p(t){const n=await l.dapi.files.readAsText(t);return e.DataFrame.fromCsv(n)}const g=t=>async()=>{const n=o[t],i=e.DataFrame.fromCsv(n);return await l.data.detectSemanticTypes(i),i};(0,t.t6)("NegativeStartEnd",async()=>{await T(["START","END"])}),(0,t.t6)("NegativeStartEndIntermediate",async()=>{await T(["START","END","INTERMEDIATE"])}),(0,t.t6)("FastaDna1",async()=>{await m(g("csvFastaDna1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.DNA,4,!1)}),(0,t.t6)("FastaRna1",async()=>{await m(g("fastaRna1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.RNA,4,!1)}),(0,t.t6)("FastaPt1",async()=>{await m(g("fastaPt1"),"seq",n,c.Hi.FASTA,"SEQ",c.YI.PT,20,!1)}),(0,t.t6)("FastaPtGaps",()=>A(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEYV"],n,c.Hi.FASTA,"SEQ",c.YI.PT,20,!1)),(0,t.t6)("FastaPtGapsMsa",()=>A(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEY"],n,c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1)),(0,t.t6)("FastaUn",async()=>{await m(g("fastaUn"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.UN,12,!0)}),(0,t.t6)("FastaMsaDna1",async()=>{await m(g("fastaMsaDna1"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.DNA,4,!1)}),(0,t.t6)("FastaMsaPt1",async()=>{await m(g("fastaMsaPt1"),"seq",n,c.Hi.FASTA,"SEQ.MSA",c.YI.PT,20,!1)}),(0,t.t6)("SepDna",async()=>{await m(g("sepDna"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.DNA,4,!1,"*")}),(0,t.t6)("SepRna",async()=>{await m(g("sepRna"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.RNA,4,!1,"*")}),(0,t.t6)("SepPt",async()=>{await m(g("sepPt"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.PT,20,!1,"-")}),(0,t.t6)("SepUn1",async()=>{await m(g("sepUn1"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.UN,8,!0,"-")}),(0,t.t6)("SepUn2",async()=>{await m(g("sepUn2"),"seq",n,c.Hi.SEPARATOR,"SEQ",c.YI.UN,9,!0,"/")}),(0,t.t6)("SepMsaN1",async()=>{await m(g("sepMsaDna1"),"seq",n,c.Hi.SEPARATOR,"SEQ.MSA",c.YI.DNA,4,!1,"-")}),(0,t.t6)("SepMsaUnWEmpty",async()=>{await 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d(o("fastaUnMsa1LikelyName"),"seq")})}),(0,t.L1)("detectorsBenchmark",()=>{let n,i;async function o(o,s,a,l,u,h){return await async function(o){const d=await(async()=>{const t=function(t,n,i,o,r){let s;switch(t){case c.Hi.FASTA:s=e=>{let t="";for(let n=0;n<e.length;n++){const i=e[n];t+=1==i.length?i:`[${i}]`}return t};break;case c.Hi.SEPARATOR:s=(e,t)=>e.join(t);break;default:throw new Error(`Not supported notation '${t}'.`)}const a=(e,t)=>{const n=new Array(t);for(let i=0;i<t;i++)n[i]=e[Math.floor(Math.random()*e.length)];return s(n,r)},l=Array(o);for(let e=0;e<o;e++)l[e]=a(n,i);return e.Column.fromStrings("seq",l)}(s,[...(0,c.Qf)(a)],l,u,h),n=i.prepare({col:t});return r(n),n})(),m=Date.now(),p=r(d),g=Date.now();(function(e,i){const o=n.getSeqHandler(e);(0,t.E3)(e.semType===i.semType,!0),(0,t.E3)(o.notation===i.notation,!0),(0,t.E3)(o.alphabet===i.alphabet,!0),(0,t.E3)(o.separator===i.separator,!0)})(p,{semType:e.SEMTYPE.MACROMOLECULE,notation:s,alphabet:a,separator:h});const 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S=n(608),M=n(1619);async function x(n,i){const o=e.DataFrame.fromCsv(n);await l.data.detectSemanticTypes(o);const r=e.DataFrame.fromCsv(i),s=o.getCol("seq");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const a=r.getCol("seq"),c=await(0,S.eE)(o,s,!0);(0,t.J6)(c.toList(),a.toList())}(0,t.L1)("MSA",async()=>{let n;async function i(i,o,r,s,a,u){const h=e.DataFrame.fromCsv(i);await l.data.detectSemanticTypes(h);const d=e.DataFrame.fromCsv(o).getCol("seq"),m=h.getCol("seq");(0,t.E3)(m.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(m.meta.units,r),a&&(0,t.E3)(m.getTag(c.gp.alphabet),a);const p=await(0,M.D)({col:m,pepsea:{method:u}},n);(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,s),(0,t.E3)(p.getTag(c.gp.aligned),"SEQ.MSA"),a&&(0,t.E3)(p.getTag(c.gp.alphabet),a),(0,t.J6)(p.toList(),d.toList())}(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("isCorrect",async()=>{await 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docker"}),(0,t.t6)("isCorrectHelmLong",async()=>{await i("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2}$$$$\n PEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\n PEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2\n meI.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me.\n Lys_Boc.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me.",c.Hi.HELM,c.Hi.SEPARATOR,void 0,"mafft")},{timeout:8e4,skipReason:"Fails in docker"}),(0,t.t6)("isCorrectSeparator",async()=>{await i("seq\n F-W-P-H-E-Y\n Y-N-R-Q-W-Y-V\n M-K-P-S-E-Y-V","seq\n FWPHEY-\n YNRQWYV\n MKPSEYV",c.Hi.SEPARATOR,c.Hi.FASTA,c.YI.PT)}),(0,t.t6)("isCorrectSeparatorLong",async()=>{await i("seq\n 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H=n(4139),D=n(4356);async function k(e,n){const i=(0,c.J9)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(i)} .`),(0,t.J6)(I().count(0).take(i.length).map(e=>i.getOriginal(e)).toArray(),n)}async function F(e,n){const i=(0,L.qp)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(i)} .`),(0,t.J6)(I().count(0).take(i.length).map(e=>i.getOriginal(e)).toArray(),n)}(0,t.L1)("splitters",async()=>{(0,t.gM)(async()=>{}),(0,t.Pl)(async()=>{});const e=["M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",["M","MeI","Y","K","E","T","L","L","MeF","P","K","T","D","F","P","M","R","G","G","L","MeA"]],n=["[meI][Pip][dK][Thr_PO3H2][L-hArg(Et,Et)][D-Tyr_Et][Tyr_ab-dehydroMe][dV]EN[D-Orn][D-aThr][Phe_4Me]",["meI","Pip","dK","Thr_PO3H2","L-hArg(Et,Et)","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],i=["PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],o=["PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.D-Dap.dV.E.N.pnG.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],r=["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[D-Dap].[dV].E.N.[pnG].[Phe_4Me]}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],s=["RNA1{R(U)P.R(T)P.R(G)P.R(C)P.R(A)}$$$$",["R(U)P","R(T)P","R(G)P","R(C)P","R(A)"]],a=["RNA1{P.R(U)P.R(T)}$$$$",["P","R(U)P","R(T)"]],l=["RNA1{P.R(U).P.R(T)}$$$$",["P","R(U)","P","R(T)"]];(0,t.t6)("fastaMulti",async()=>{await 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r=l.shell.addTableView(o);await O(r.grid),(0,t.E3)(r.grid.dataFrame.id,e.id)}),(0,t.t6)("getHelmMonomers",async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await l.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],i=t.getCol("HELM"),o=await l.functions.call("Bio:getHelmMonomers",{sequence:i}),r=n.filter(e=>!o.includes(e)),s=o.filter(e=>!n.includes(e));if(r.length>0||s.length){const e=[];throw r.length>0&&e.push(`Missed monomers ${JSON.stringify(r)}.`),s.length>0&&e.push(`Unexpected monomers ${JSON.stringify(s)}.`),new Error(e.join(" "))}})});var G=n(8604);(0,t.L1)("monomerLibraries",()=>{let e,n=null;(0,t.gM)(async()=>{e=await(0,_.pj)(),n=(0,D.u)()}),(0,t.Pl)(async()=>{await(0,D.E)(n)}),(0,t.t6)("default",async()=>{await(0,D.E)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadMonomerLib(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)}),(0,t.t6)("forTests",async()=>{await e.loadMonomerLibForTests(),function(e,t){const n=t,i=e.getSummaryObj();for(const e in n)n[e]||delete n[e];for(const e in i)i[e]||delete i[e];if(0==Object.keys(n).length&&0!=Object.keys(i).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(n).length&&0==Object.keys(i).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,o.Xk)(i,n),(0,o.Xk)(n,i)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(n)} does not match actual ${JSON.stringify(i)}.`)}}(e.getMonomerLib(),G.V)}),(0,t.t6)("empty",async()=>{const n=await(0,D.u)();let i=await e.getAvaliableLibraryNames();0===i.length&&(await e.refreshValidLibraryLists(),i=await e.getAvaliableLibraryNames()),n.exclude=i,n.explicit=[],await(0,D.E)(n),await e.loadMonomerLib(!0);const o=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===o.length,!0)}),(0,t.t6)("override",async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},i=e.getMonomerLib(),o=i.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null==o,!0,`Unexpectedly found monomer '${n.symbol}' `);const r=i.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);r&&(r.lib=void 0),(0,t.Xk)(r,n)})});var B=n(7389),V=n(1757),U=n.n(V),W=n(1858),q=n(6873),Y=n(5433);async function j(n,i){const o=n(),r=e.DataFrame.fromColumns(o);await l.data.detectSemanticTypes(r);const s=Date.now(),a=(r.columns.byName("MSA"),l.shell.addTableView(r));await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,r.id);const c=Date.now()-s;console.log(`Performance test: ${i}: ${c}ms`)}(0,t.L1)("renderers",()=>{let n;(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("long sequence performance ",async()=>{await j(()=>(0,q.dW)(1e4),"Long sequences")}),(0,t.t6)("many sequence performance",async()=>{await j(q.fD,"Many sequences")}),(0,t.t6)("rendererMacromoleculeFasta",async()=>{await async function(){const n=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),i=e.DataFrame.fromCsv(n),o=i.getCol("Sequence"),r=await l.functions.call("Bio:detectMacromolecule",{col:o});r&&(o.semType=r);const s=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(s.grid),(0,t.E3)(s.grid.dataFrame.id,i.id);const a=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(a,"sequence")}()}),(0,t.t6)("rendererMacromoleculeSeparator",async()=>{await async function(){const n=await l.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),i=e.DataFrame.fromCsv(n),o=i.getCol("sequence"),r=await l.functions.call("Bio:detectMacromolecule",{col:o});r&&(o.semType=r);const s=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(s.grid),(0,t.E3)(s.grid.dataFrame.id,i.id);const a=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(a,"sequence")}()}),(0,t.t6)("rendererMacromoleculeDifference",async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=H.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await O(o.grid),(0,t.E3)(o.grid.dataFrame.id,i.id);const r=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(r,H.uF.MACROMOLECULE_DIFFERENCE)}()}),(0,t.t6)("afterMsa",async()=>{await async function(){const i=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),o=(await l.functions.call("Bio:importFasta",{fileContent:i}))[0],r=o.getCol("sequence"),s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=l.shell.addTableView(o);await l.data.detectSemanticTypes(o),console.log("Bio: tests/renderers/afterMsa, table view"),await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${r.semType}", units="${r.meta.units}", cell.renderer="${r.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(r.meta.units,c.Hi.FASTA),(0,t.E3)(r.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(r.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(r.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,M.D)({col:r},n);await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()}),(0,t.t6)("afterConvert",async()=>{await async function(){const i=await l.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),o=e.DataFrame.fromCsv(i),r=o.getCol("sequence"),s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=l.shell.addTableView(o);await l.data.detectSemanticTypes(o);const u=await(0,Y.r)(r,n,c.Hi.SEPARATOR,"/");await O(a.grid),(0,t.E3)(a.grid.dataFrame.id,o.id);const h=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(h,"sequence"),n.getSeqHandler(u)}()}),(0,t.t6)("afterConvertToHelm",async()=>{await async function(){const i=await l.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),o=l.shell.addTableView(i);await O(o.grid),await i.meta.detectSemanticTypes(),await l.data.detectSemanticTypes(i);const r=i.getCol("sequence"),s=n.getSeqHandler(r).convert(c.Hi.HELM);i.columns.add(s),await O(o.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()}),(0,t.t6)("selectRendererBySemType",async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=H.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]);l.shell.addTableView(i),await(0,t.cb)(100);const o=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==o)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${o}' instead of correct 'MacromoleculeDifference'.`)}()}),(0,t.t6)("scatterPlotTooltip",async()=>{await async function(){const n=e.DataFrame.fromCsv(i);n.currentRowIdx=0;const o=l.shell.addTableView(n);await n.meta.detectSemanticTypes(),await l.data.detectSemanticTypes(n);const r=n.plot.scatter({x:"x",y:"y"});o.dockManager.dock(r,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(r.onAfterDrawScene,()=>{},()=>{r.invalidateCanvas()},1e3),O(o.grid,500)]);const s=r.root.getBoundingClientRect(),a=r.worldToScreen(1,0),c=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:s.left+a.x,clientY:s.top+a.y}),u=U()(r.root).find("canvas").get()[0];await(0,t.PE)(e.debounce((0,W.fromEvent)(u,"mousemove"),200),()=>{Re.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(U()(B.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(r.hitTest(a.x,a.y),1)},()=>{u.dispatchEvent(c)},500),await O(o.grid,500)}()});const i="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"});var K=n(6882);(0,t.L1)("renderers: monomerPlacer",()=>{let n,i;(0,t.gM)(async()=>{n=await(0,_.pj)(),i=await(0,D.u)(),await n.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(i),await n.loadMonomerLib(!0)});const o={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:190},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,i]of Object.entries(o))(0,t.t6)(`getPosition-${n}`,async()=>{const t=e.DataFrame.fromCsv(i.csv);await l.data.detectSemanticTypes(t);const n=t.getCol("seq"),o=new K.Jy(null,n,Re.logger,3,()=>({font:"12px monospace",fontCharWidth:7,separatorWidth:12,monomerToShort:c.zS}));await o.init();const r=i.testList;for(let e=0;e<n.length;++e)o.getCellMonomerLengths(e,1e4);const s=[];for(const[e,t]of I().enumerate(r)){const t={pos:o.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&s.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(s.length>0)throw new Error("Test failed error(s):\n"+s.join(", \n"))});const r=[10,20,30,40,50,60],s={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(s))(0,t.t6)("hitBounds-"+e,async()=>{const e=(0,K.Bb)(r,n.x);(0,t.E3)(e,n.tgt)});const a={mono1:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6/m7/m8/m9\nn1/m2/n3/m4/n5/m6/n7/m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGaps:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGapColumn:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5///n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,180,206,232]}}};for(const[n,i]of Object.entries(a))(0,t.t6)(`getCellMonomerLengths-${n}`,async()=>{const n=e.DataFrame.fromCsv(i.src.csv);await l.data.detectSemanticTypes(n);const o=n.getCol("seq"),r=new K.Jy(null,o,Re.logger,3,()=>({fontCharWidth:7,font:"12px monospace",separatorWidth:12,monomerToShort:c.zS}));await r.init();const s=r.getCellMonomerLengths(0,1e3)[1];(0,t.J6)(s,i.tgt.lengths)})}),(0,t.L1)("converters",()=>{let n,i;(0,t.gM)(async()=>{n=await(0,u.Q)()}),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(i||(i={}));const o={[i.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[i.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[i.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[i.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[i.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[i.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[i.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[i.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[i.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[i.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[i.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[i.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[i.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[i.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[i.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[i.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[i.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[i.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},r=new Set(Object.values(c.gp));async function s(t){const n=o[t],i=e.DataFrame.fromCsv(n);return await l.data.detectSemanticTypes(i),i}function a(e,i){if(e===c.Hi.SEPARATOR&&!i)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(o){const r=n.getSeqHandler(o).convert(e,i);return(0,t.E3)(r.meta.units,e),r}}async function h(e,i,o){const a=(await s(e)).getCol("seq"),l=i(a),u=(await s(o)).getCol("seq");(0,t.J6)(l.toList(),u.toList());const h=n.getSeqHandler(a),d=n.getSeqHandler(l);for(const[e,n]of Object.entries(u.tags)){if(!r.has(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const i=l.getTag(e);(0,t.E3)(i,n,`Tag '${e}' expected value '${n}' is not equal to actual '${i}'.`)}}(0,t.t6)("testFastaPtToSeparator",async()=>{await h(i.fastaPt,a(c.Hi.SEPARATOR,"-"),i.separatorPt)}),(0,t.t6)("testFastaDnaToSeparator",async()=>{await h(i.fastaDna,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testFastaRnaToSeparator",async()=>{await h(i.fastaRna,a(c.Hi.SEPARATOR,"*"),i.separatorRna)}),(0,t.t6)("testFastaGapsToSeparator",async()=>{await h(i.fastaGaps,a(c.Hi.SEPARATOR,"/"),i.separatorGaps)}),(0,t.t6)("testFastaUnToSeparator",async()=>{await h(i.fastaUn,a(c.Hi.SEPARATOR,"-"),i.separatorUn)}),(0,t.t6)("testFastaPtToHelm",async()=>{await h(i.fastaPt,a(c.Hi.HELM),i.helmPt)}),(0,t.t6)("testFastaDnaToHelm",async()=>{await h(i.fastaDna,a(c.Hi.HELM),i.helmDna)}),(0,t.t6)("testFastaRnaToHelm",async()=>{await h(i.fastaRna,a(c.Hi.HELM),i.helmRna)}),(0,t.t6)("testFastaGapsToHelm",async()=>{await h(i.fastaGaps,a(c.Hi.HELM),i.helmGaps)}),(0,t.t6)("testSeparatorPtToFasta",async()=>{await h(i.separatorPt,a(c.Hi.FASTA),i.fastaPt)}),(0,t.t6)("testSeparatorDnaToFasta",async()=>{await h(i.separatorDna,a(c.Hi.FASTA),i.fastaDna)}),(0,t.t6)("testSeparatorRnaToFasta",async()=>{await h(i.separatorRna,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testSeparatorGapsToFasta",async()=>{await h(i.separatorGaps,a(c.Hi.FASTA),i.fastaGaps)}),(0,t.t6)("testSeparatorUnToFasta",async()=>{await h(i.separatorUn,a(c.Hi.FASTA),i.fastaUn)}),(0,t.t6)("testSeparatorPtToHelm",async()=>{await h(i.separatorPt,a(c.Hi.HELM),i.helmPt)}),(0,t.t6)("testSeparatorDnaToHelm",async()=>{await h(i.separatorDna,a(c.Hi.HELM),i.helmDna)}),(0,t.t6)("testSeparatorRnaToHelm",async()=>{await h(i.separatorRna,a(c.Hi.HELM),i.helmRna)}),(0,t.t6)("testSeparatorGapsToHelm",async()=>{await h(i.separatorGaps,a(c.Hi.HELM),i.helmGaps)}),(0,t.t6)("testHelmDnaToFasta",async()=>{await h(i.helmDna,a(c.Hi.FASTA),i.fastaDna)}),(0,t.t6)("testHelmRnaToFasta",async()=>{await h(i.helmRna,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testHelmPtToFasta",async()=>{await h(i.helmPt,a(c.Hi.FASTA),i.fastaPt)}),(0,t.t6)("testHelmUnToFasta",async()=>{await h(i.helmUn,a(c.Hi.FASTA),i.fastaUn)}),(0,t.t6)("testHelmDnaToSeparator",async()=>{await h(i.helmDna,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testHelmRnaToSeparator",async()=>{await h(i.helmRna,a(c.Hi.SEPARATOR,"*"),i.separatorRna)}),(0,t.t6)("testHelmPtToSeparator",async()=>{await h(i.helmPt,a(c.Hi.SEPARATOR,"-"),i.separatorPt)}),(0,t.t6)("testHelmUnToSeparator",async()=>{await h(i.helmUn,a(c.Hi.SEPARATOR,"-"),i.separatorUn)}),(0,t.t6)("testHelmLoneRibose",async()=>{await h(i.helmLoneRibose,a(c.Hi.FASTA),i.fastaRna)}),(0,t.t6)("testHelmLoneDeoxyribose",async()=>{await h(i.helmLoneDeoxyribose,a(c.Hi.SEPARATOR,"/"),i.separatorDna)}),(0,t.t6)("testHelmLonePhosphorus",async()=>{await h(i.helmLonePhosphorus,a(c.Hi.FASTA),i.fastaRna)});for(const e of v)(0,t.t6)(`testBilnToHelm_${e.name}`,async()=>{await y(e.biln,e.helm,n)});for(const e of C)(0,t.t6)(`testHelmToBiln_${e.name}`,async()=>{await b(e.helm,e.biln,n)})});var z=n(3516);(0,t.L1)("fastaFileHandler",()=>{const n=["description:1","description:2","description:3","description:4"],i=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function o(e){const o=new z.m(e),r=o.descriptionsArray,s=o.sequencesArray;(0,t.J6)([r,s],[n,i])}(0,t.t6)("testNormalFormatting",async()=>{o(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")}),(0,t.t6)("testExtraSpaces",async()=>{o(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n 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o=e.DataFrame.fromCsv(i).getCol("seq");o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=c.Hi.FASTA,o.setTag(c.gp.alphabet,"UN"),o.setTag(c.gp.alphabetSize,"11"),o.setTag(c.gp.alphabetIsMultichar,"true"),o.setTag(c.gp.aligned,"SEQ");const[r,s]=(0,ie.l)(o,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(r,!1)}),(0,t.t6)("testGetActionFunctionMeta",async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find(e=>"sequence"==e.name)})}),(0,t.L1)("similarity/diversity",async()=>{(0,t.t6)("similaritySearchViewer",async()=>{await async function(){const n=await Re.files.readAsText("tests/sample_MSA_data.csv"),i=e.DataFrame.fromCsv(n);await l.data.detectSemanticTypes(i);const o=l.shell.addTableView(i),r=o.dataFrame.getCol("MSA");(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const s=await o.dataFrame.plot.fromType("Sequence Similarity Search");let 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created",100);(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.scores.get(0),e.FLOAT_NULL),(0,t.E3)(c.idxs.get(0),0),(0,t.E3)(c.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(c.scores.get(1).toFixed(2),"0.10"),(0,t.E3)(c.idxs.get(1),7),(0,t.E3)(c.molCol.get(1),"/D-Tyr_Et/meQ/dV/E/N/dV///Phe_4Me"),o.dataFrame.currentRowIdx=1,await(0,t.bk)(()=>1===c.targetMoleculeIdx,"Target molecule has not been changed",5e3),await(0,t.bk)(()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===c.molCol.get(0),"Incorrect first similar molecule",5e3)}()}),(0,t.t6)("diversitySearchViewer",async()=>{await async function(){const n=await Re.files.readAsText("tests/sample_MSA_data.csv"),i=e.DataFrame.fromCsv(n),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i);const r=o.dataFrame.getCol("MSA");(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const s=await o.dataFrame.plot.fromType("Sequence Diversity Search");let a=!1;if(s.computeCompleted.subscribe(e=>{e&&(a=!0)}),o.dockManager.dock(s,e.DOCK_TYPE.DOWN,null,"Diversity"),await s.renderPromise,await(0,t.bk)(()=>void 0!==oe(o,"Sequence Diversity Search"),"Sequence Diversity Search viewer has not been created",100),!s.initialized)throw new Error("The viewer is not initialized.");if(!s.targetColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!s.beforeRender())throw new Error("The viewer is not able to render.");if(!s.computeRequested)throw new Error("The viewer has not compute requested even.");if(!a)throw new Error("The viewer has not compute completed.");const c=s;await(0,t.bk)(()=>0!==c.root.getElementsByClassName("d4-grid").length,"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.initialized,!0),(0,t.E3)(c.renderMolIds.length>0,!0)}()})});var re=n(1687),se=n(4574);(0,t.L1)("bio-substructure-filters",async()=>{let n,i,o;async function r(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const i=new re._i(n,Re.logger);return i.attach(t),i.applyState({columnName:e}),i.column=t.col(e),i.columnName=e,i}(0,t.gM)(async()=>{n=await(0,u.Q)(),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)}),(0,t.t6)("fasta",async()=>{const e=await $("tests/filter_FASTA.csv");await l.data.detectSemanticTypes(e);const i=new re._i(n,Re.logger);i.attach(e),await i.awaitRendered();try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"FastaBioFilter");const n=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new se.n("MD",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,3),(0,t.E3)(i.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{i.detach()}await i.awaitRendered()}),(0,t.t6)("separator",async()=>{const e=await $("tests/filter_MSA.csv"),i=new re._i(n,Re.logger);await l.data.detectSemanticTypes(e),i.attach(e),await i.awaitRendered();try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter");const n=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("meI",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,7),(0,t.E3)(i.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("/meI",void 0,Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{n.props=new re.AR("meI-hHis","-",Re.logger)},5e3,"testEvent onRowsFiltered"),(0,t.E3)(i.dataFrame.filter.trueCount,7),(0,t.E3)(i.dataFrame.filter.get(2),!1)}finally{i.detach()}await i.awaitRendered()}),(0,t.t6)("helm-dialog",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e="Bio tests: substructureFilters/helm-dialog",i=await $("tests/filter_HELM.csv"),o=l.shell.addTableView(i);await l.data.detectSemanticTypes(i),await i.meta.detectSemanticTypes(),Re.logger.debug(`${e}, filter attaching.`);const r=new re._i(n,Re.logger);r.attach(i);const s=B.dialog("Test filters").add(r.root).show();await r.awaitRendered();try{const n=r.bioFilter;(0,t.E3)(null!==r.bioFilter,!0,"bioFilter is not created"),Re.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(i.onRowsFiltered,()=>{},()=>{n.props=new se.n("PEPTIDE1{A.C}$$$$V2.0",void 0,Re.logger)},2e4),Re.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(r.dataFrame.filter.trueCount,1),(0,t.E3)(r.dataFrame.filter.toBinaryString(),"0001"),Re.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(i.onRowsFiltered,()=>{},()=>{n.props=new se.n("PEPTIDE1{C}$$$$V2.0",void 0,Re.logger)},2e4),setTimeout(()=>o.grid.invalidate(),500),await O(o.grid),await(0,t.cb)(1e3),Re.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(r.dataFrame.filter.trueCount,2),(0,t.E3)(r.dataFrame.filter.toBinaryString(),"1001")}finally{s.close()}await r.awaitRendered(),await(0,t.cb)(3e3)}},{}),(0,t.t6)("helm-view",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await $("tests/filter_HELM.csv");e.getCol("HELM string"),await l.data.detectSemanticTypes(e);const t=l.shell.addTableView(e);t.getFiltersGroup(),await O(t.grid)}}),(0,t.t6)("sync-fasta",async()=>{const e=await Re.files.readCsv("tests/filter_FASTA.csv");await l.data.detectSemanticTypes(e);const n=await r("fasta",e),i=await r("fasta",e);await Promise.all([n.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(i.bioFilter.type,"FastaBioFilter");const o=n.bioFilter,r=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{o.props=new se.n("MD",void 0,Re.logger)},1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(r.props.substructure,"MD")}finally{n.detach(),i.detach()}await Promise.all([n.awaitRendered(),i.awaitRendered()])}),(0,t.t6)("sync-msa",async()=>{const e=await Re.files.readCsv("tests/filter_MSA.csv");await l.data.detectSemanticTypes(e);const n="hHis-Aca",i=await r("MSA",e),o=await r("MSA",e);await Promise.all([i.awaitRendered(),o.awaitRendered()]);try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(!!o.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(o.bioFilter.type,"SeparatorBioFilter");const r=i.bioFilter,s=o.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{r.props=new re.AR(n,"-",Re.logger)},1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(s.props.substructure,n),(0,t.E3)(s.props.separator,"-")}finally{i.detach(),o.detach()}await Promise.all([i.awaitRendered(),o.awaitRendered()])}),(0,t.t6)("sync-helm",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await Re.files.readCsv("tests/filter_HELM.csv");await l.data.detectSemanticTypes(e);const n=l.shell.addTableView(e),i="PEPTIDE1{A.C}$$$$V2.0",o=1,s=await r("HELM string",e),a=await r("HELM string",e),c=B.dialog("Test filters").add(s.root).add(a.root).show();await Promise.all([s.awaitRendered(),a.awaitRendered()]);try{(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(!!a.bioFilter,!0),(0,t.E3)(s.bioFilter.type,"HelmBioFilter"),(0,t.E3)(a.bioFilter.type,"HelmBioFilter");const r=s.bioFilter,l=a.bioFilter;await(0,t.PE)(e.onRowsFiltered,()=>{},()=>{r.props=new se.n(i,void 0,Re.logger)},6e4,"await onRowsFiltered"),await O(n.grid),Re.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*s.debounceTime),Re.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,o),await s.awaitRendered(),(0,t.E3)(l.props.substructure,i)}finally{s.detach(),a.detach(),c.close()}await Promise.all([s.awaitRendered(),a.awaitRendered()]),await O(n.grid),await(0,t.cb)(3e3)}}),(0,t.t6)("two-columns-fasta",async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await l.data.detectSemanticTypes(n);const i=l.shell.addTableView(n),o="seq1",r="CGGCTG",s=n.getCol("trueSeq1").toList(),a="seq2",c="GCATT",u=n.getCol("trueSeq2").toList(),h=[{type:"Bio:bioSubstructureFilter",columnName:o},{type:"Bio:bioSubstructureFilter",columnName:a}],d=await n.plot.fromType(e.VIEWER.FILTERS,{filters:h});i.dockManager.dock(d,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid);const m=d.filters[0],p=d.filters[1];(0,t.E3)(m.column.name,o),(0,t.E3)(p.column.name,a);const g=m.bioFilter,f=p.bioFilter;await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n(r,void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n("",void 0,Re.logger)},1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,s.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),s.map(e=>e.toString()).join("")),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n("",void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n(c,void 0,Re.logger)},1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),u.map(e=>e.toString()).join("")),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n("",void 0,Re.logger)},1e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n("",void 0,Re.logger)},1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{g.props=new se.n(r,void 0,Re.logger)},5e3),await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{f.props=new se.n(c,void 0,Re.logger)},5e3,"testEvent onRowsFiltered on both");const y=I().count(0).take(n.rowCount).map(e=>s[e]*u[e]).toArray();(0,t.E3)(n.filter.trueCount,y.filter(e=>1===e).length),(0,t.E3)(n.filter.toBinaryString(),y.map(e=>e.toString()).join("")),await Promise.all([m.awaitRendered(),p.awaitRendered(),O(i.grid)])},{skipReason:"Inconsistent behavior of test"}),(0,t.t6)("reset-fasta",async()=>{const n=await $("tests/filter_FASTA.csv"),i=l.shell.addTableView(n);await l.data.detectSemanticTypes(n),await n.meta.detectSemanticTypes();const o="MD",r=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});i.dockManager.dock(r,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid);const s=r.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,()=>{},()=>{s.props=new se.n(o,void 0,Re.logger)},1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(s.props.substructure,o),(0,t.E3)(s.substructureInput.value,o),U()(r.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await O(i.grid),(0,t.E3)(s.props.substructure,""),(0,t.E3)(s.substructureInput.value,"")}),(0,t.t6)("reopen",async()=>{const n=await Re.files.readCsv("tests/filter_FASTA.csv"),i=l.shell.addTableView(n);await l.data.detectSemanticTypes(n),await n.meta.detectSemanticTypes();const o=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],r=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(r,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid),r.close(),await O(i.grid);const s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await O(i.grid)},{})});var ae=n(8152);class le{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var ce=n(9192);(0,t.L1)("PepSeA",()=>{(0,t.t6)("Basic alignment",async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),i=await(0,ae.GD)(n,n.getCol("HELM"),"msa(HELM)"),o=n.getCol("MSA");for(let e=0;e<i.length;++e)(0,t.E3)(i.get(e)==o.get(e),!0)},{timeout:6e4,skipReason:"Fails in docker"}),(0,t.t6)("stderr",async()=>{const n=new le,i=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),o=await(0,ae.GD)(i,i.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),r=i.getCol("MSA");(0,t.J6)(o.toList(),r.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")},{timeout:6e4,skipReason:"Fails in docker"}),(0,t.t6)("error",async()=>{const n=new le;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,ae.GD)(t,t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,i]=(0,ce.AP)(e);n.error(t,void 0,i)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")},{skipReason:"Fails in docker"})});const ue="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",he="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",de="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var me;(0,t.L1)("SeqHandler",()=>{let n;async function i(t){const i=e.DataFrame.fromCsv(t);await l.data.detectSemanticTypes(i);const o=n.getSeqHandler(i.getCol("seq"));return[i,o]}(0,t.gM)(async()=>{n=await(0,u.Q)()}),(0,t.t6)("Seq-Fasta",async()=>{const[e,n]=await i(ue);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)}),(0,t.t6)("Seq-Fasta-MSA",async()=>{const[e,n]=await i(he);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)}),(0,t.t6)("Seq-Fasta-units",async()=>{const[e,n]=await i(ue);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)}),(0,t.t6)("Seq-Fasta-MSA-units",async()=>{const[e,n]=await i(he);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)}),(0,t.t6)("Seq-Helm",async()=>{const[e,n]=await i("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(n.notation,c.Hi.HELM),(0,t.E3)(n.isHelm(),!0)}),(0,t.t6)("Seq-UN",async()=>{const[e,n]=await i(de);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)}),(0,t.t6)("Seq-UN-auto",async()=>{const[e,n]=await i(de);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)}),(0,t.t6)("column-version",async()=>{const i=e.DataFrame.fromCsv(ue);await 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n;(0,t.gM)(async()=>{n=await(0,u.Q)()}),Q.b9[c.Hi.FASTA],Q.b9[c.Hi.HELM];const 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s=n.getSeqHandler(i).getRegion(r.startIdx,r.endIdx,"regSeq"),a=e.DataFrame.fromCsv(r.tgtCsv).getCol("seq");(0,t.E3)(i.meta.units,r.units),(0,t.E3)(s.meta.units,r.units),(0,t.E3)(i.getTag(c.gp.alphabet),r.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),r.alphabet),(0,t.J6)(s.toList(),a.toList())}),r.positionNames&&(0,t.t6)(`${o}-positionNames`,async()=>{const n=e.DataFrame.fromCsv(r.srcCsv).getCol("seq");r.positionNames.tag&&n.setTag(c.gp.positionNames,r.positionNames.tag);const i=await l.functions.call("Bio:detectMacromolecule",{col:n});i&&(n.semType=i);const o=await l.functions.call("Bio:getRegion",{sequence:n,start:r.positionNames.start,end:r.positionNames.end}),s=e.DataFrame.fromCsv(r.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,r.units),(0,t.E3)(o.meta.units,r.units),(0,t.E3)(n.getTag(c.gp.alphabet),r.alphabet),(0,t.E3)(o.getTag(c.gp.alphabet),r.alphabet),(0,t.J6)(o.toList(),s.toList())})}),(0,t.L1)("SeqHandler: getHelm",()=>{let n,i,o;(0,t.gM)(async()=>{n=await(0,u.Q)(),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)});const r={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(r))(0,t.t6)(e,async()=>{await s(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)});async function s(i,o,r,s){const a=e.Column.fromStrings("seq",[i]),c=e.DataFrame.fromColumns([a]);await l.data.detectSemanticTypes(c);const u=n.getSeqHandler(a),h=(await u.getValue(0)).helm;(0,t.E3)(h,s)}});var pe=n(2582);(0,t.L1)("helm",()=>{const e={"single-linear":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T.[meI]}$$$$"},tgt:{simplePolymers:[6],connections:[],bondedRGroups:[1,2,2,2,2,1]}},"single-cyclized-C-2-2":{src:{helm:"PEPTIDE1{R.F.C.Y.G.H.[GGaz].C.T.[meI]}$PEPTIDE1,PEPTIDE1,3:R3-8:R3$$$"},tgt:{simplePolymers:[10],connections:[[["PEPTIDE1",3,"R3"],["PEPTIDE1",8,"R3"]]],bondedRGroups:[1,2,3,2,2,2,2,3,2,1]}},"single-cyclized-C-1-1":{src:{helm:"PEPTIDE1{F.C.Y.G.H.[GGaz].C.[meI]}$PEPTIDE1,PEPTIDE1,2:R3-7:R3$$$"},tgt:{simplePolymers:[8],connections:[[["PEPTIDE1",2,"R3"],["PEPTIDE1",7,"R3"]]],bondedRGroups:[1,3,2,2,2,1,3,1]}},"single-cyclized-C-0-0":{src:{helm:"PEPTIDE1{C.Y.G.H.[GGaz].C}$PEPTIDE1,PEPTIDE1,1:R3-6:R3$$$"},tgt:{simplePolymers:[6],connections:[[["PEPTIDE1",1,"R3"],["PEPTIDE1",6,"R3"]]],bondedRGroups:[2,2,2,2,2,2]}},"two-separated-5-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$$$$"},tgt:{simplePolymers:[5,1],connections:[],bondedRGroups:[1,2,2,2,1,0]}},"two-separated-1-5":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.Y.[GGaz].T}$$$$"},tgt:{simplePolymers:[1,5],connections:[],bondedRGroups:[0,1,2,2,2,1]}},"two-separated-4-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$$$$"},tgt:{simplePolymers:[4,2],connections:[],bondedRGroups:[1,2,2,1,1,1]}},"two-connected-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$PEPTIDE1,PEPTIDE2,5:R2-1:R1$$$"},tgt:{simplePolymers:[5,1],connections:[[["PEPTIDE1",5,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-connected-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$PEPTIDE1,PEPTIDE2,4:R2-1:R1$$$"},tgt:{simplePolymers:[4,2],connections:[[["PEPTIDE1",4,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-cyclized-1-9":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.[GGaz].T.G.H.F.Y.P}$PEPTIDE2,PEPTIDE2,3:R3-9:R2|PEPTIDE2,PEPTIDE1,3:R4-1:R1$$$V2.0"},tgt:{simplePolymers:[1,9],connections:[[["PEPTIDE2",3,"R3"],["PEPTIDE2",9,"R2"]],[["PEPTIDE2",3,"R4"],["PEPTIDE1",1,"R1"]]],bondedRGroups:[1,1,2,4,2,2,2,2,2,1]}}};for(const[n,{src:i,tgt:o}]of Object.entries(e))(0,t.t6)(n,async()=>{const e=new pe.f(i.helm),n=e.simplePolymers.map(e=>e.monomers.length),r=n.reduce((e,t)=>e+t,0);(0,t.J6)(n,o.simplePolymers);const s=e.connectionList.getConnectionData().map(e=>[[e[0].polymerId,e[0].bond.monomerIdx+1,`R${e[0].bond.rGroupId}`],[e[1].polymerId,e[1].bond.monomerIdx+1,`R${e[1].bond.rGroupId}`]]);(0,t.J6)(s,o.connections);const a=I().count(0).take(e.bondedRGroupsMap.length).map(t=>e.bondedRGroupsMap[t].length).toArray();(0,t.E3)(r,a.length)})});var ge=n(6077),fe=n(6717);const ye=new e.FileSource("System:AppData/Bio"),be={symbol:"allyl_mon",name:"monomer with Allyl R group",molfile:"\n RDKit 2D\n\n 9 8 0 0 0 0 0 0 0 0999 V2000\n 1.4434 -2.1667 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4434 -0.6667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1443 0.0833 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -1.1547 -0.6667 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.4537 0.0833 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n -3.7528 -0.6667 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 0.1443 1.5833 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.4434 2.3333 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 2.7424 0.0833 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 2 0\n 2 3 1 0\n 3 4 1 6\n 4 5 1 0\n 5 6 1 0\n 3 7 1 0\n 7 8 1 0\n 2 9 1 0\nM RGP 3 6 3 8 1 9 2\nM END\n",smiles:"O=C([C@H](CS[*:3])N[*:1])[*:2]",polymerType:"PEPTIDE",monomerType:"Backbone",naturalAnalog:"C",id:16,rgroups:[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[H][*:1]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-Allyl",capGroupName:"Allyl",capGroupSmiles:"C=C[*:3]",label:"R3"}],author:"Admin",createDate:"2026-02-18T14:48:41.723Z",meta:{}},we={symbol:"SomeComplex",name:"Some complex monomer with complex R group",molfile:"\n RDKit 2D\n\n 10 9 0 0 0 0 0 0 0 0999 V2000\n -1.4289 -0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -2.7280 0.3750 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0\n -4.0270 -0.3750 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n -0.1299 0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n -0.1299 1.8750 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 2.6250 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 -0.3750 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0\n 1.1691 -1.8750 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0\n 2.4682 -2.6250 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 2.4682 0.3750 0.0000 R# 0 0 0 0 0 0 0 0 0 0 0 0\n 1 2 1 0\n 2 3 1 0\n 4 1 1 6\n 4 5 1 0\n 5 6 1 0\n 4 7 1 0\n 7 8 1 0\n 8 9 1 0\n 7 10 1 0\nM RGP 4 3 3 6 1 9 4 10 2\nM END\n",smiles:"[*:4]OC([C@H](CS[*:3])N[*:1])[*:2]",polymerType:"PEPTIDE",monomerType:"Backbone",naturalAnalog:"C",id:16,rgroups:[{alternateId:"R1-H",capGroupName:"H",capGroupSmiles:"[H][*:1]",label:"R1"},{alternateId:"R2-OH",capGroupName:"OH",capGroupSmiles:"O[*:2]",label:"R2"},{alternateId:"R3-Something",capGroupName:"Something",capGroupSmiles:"C=CC([*:3])=C",label:"R3"},{alternateId:"R4-SomethingElse",capGroupName:"SomethingElse",capGroupSmiles:"ClCCCC=CC([*:4])=CCC",label:"R4"}],author:"Admin",createDate:"2026-02-18T14:48:41.723Z",meta:{}},ve={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},Ce="molfile(sequence)";function Te(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map(e=>e.trimEnd()).join("\n")}(0,t.L1)("toAtomicLevel",async()=>{const n={},i={};let o,r,s,a,h,d;async function m(e,n){const i=e.getCol("sequence");await l.functions.call("Bio:toAtomicLevel",{table:e,seqCol:i,nonlinear:!1});const o=e.getCol(Ce),r=n.getCol(Ce),s=I()(o.values()).map(e=>Te(e)).toArray(),a=I()(r.values()).map(e=>Te(e)).toArray();(0,t.J6)(s,a)}(0,t.gM)(async()=>{h=await(0,fe.j)(),s=await(0,u.Q)(),o=await(0,_.pj)(),r=await(0,D.u)(),await o.loadMonomerLibForTests(),a=o.getMonomerLib();for(const[t,o]of Object.entries(ve))o.inPath,n[t]=e.DataFrame.fromCsv((await ye.readAsText(o.inPath)).replace(/\n$/,"")),n[t].name=o.inPath.split("/").pop(),await l.data.detectSemanticTypes(n[t]),i[t]=e.DataFrame.fromCsv((await ye.readAsText(o.outPath)).replace(/\n$/,""))}),(0,t.Pl)(async()=>{await(0,D.E)(r),await o.loadMonomerLib(!0)});for(const[e,o]of Object.entries(ve))(0,t.t6)(`${e}`,async()=>{await m(n[e],i[e])});!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(d||(d={}));const p={[d.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[d.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[d.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[d.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[d.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[d.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[d.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[d.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[d.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function g(t){const n=p[t],i=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await l.data.detectSemanticTypes(i),i}async function f(e,n){let i=null;const r=o.getMonomerLib();r._monomers.PEPTIDE[be.symbol]=be,r._monomers.PEPTIDE[we.symbol]=we;try{const i=await s.getHelmToMolfileConverter(r),o=s.helmToAtomicLevelSingle(e,i,!0,!0),a=l.chem.convert(o.molfile,l.chem.Notation.Unknown,l.chem.Notation.Smiles);(0,t.E3)(a,n)}catch(e){i=e}if(delete r._monomers.PEPTIDE[be.symbol],delete r._monomers.PEPTIDE[we.symbol],i)throw i}async function y(e,t="seq",n){const i=e.getCol(t),o=await(0,ge.C4)(e,i,a,s,h);return o.warnings.length>0&&Re.logger.warning(`_toAtomicLevel() warnings ${o.warnings.join("\n")}`),o.molCol}(0,t.t6)("fastaDna",async()=>{await y(await g(d.fastaDna),"seq")}),(0,t.t6)("fastaRna",async()=>{await y(await g(d.fastaRna),"seq")}),(0,t.t6)("fastaPt",async()=>{await y(await g(d.fastaPt),"seq")}),(0,t.t6)("fastaUn",async()=>{await y(await g(d.fastaUn),"seq")}),(0,t.t6)("separatorDna",async()=>{await y(await g(d.separatorDna),"seq")}),(0,t.t6)("separatorDna",async()=>{await y(await g(d.separatorRna),"seq")}),(0,t.t6)("separatorPt",async()=>{await y(await g(d.separatorPt),"seq")}),(0,t.t6)("separatorUn",async()=>{await y(await g(d.separatorUn),"seq")}),(0,t.t6)("helm",async()=>{await y(await g(d.helm),"seq")}),(0,t.t6)("ptFasta2",async()=>{const n=await Re.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),i=e.DataFrame.fromCsv("seq\nAR"),o=i.getCol("seq");o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=c.Hi.FASTA,o.setTag(c.gp.alphabet,c.YI.PT),s.getSeqHandler(o);const r=await y(i,"seq");(0,t.E3)(Te(r.get(0)),Te(n))}),(0,t.t6)("SingleHelmMonomerWithAllylGroups",async()=>{const e=`PEPTIDE1{[${be.symbol}]}$$$$V2.0`;await f(e,"C=CSC[C@H](N)C(=O)O")}),(0,t.t6)("SingleHelmMonomerWithComplexRGroups",async()=>{const e=`PEPTIDE1{[${we.symbol}]}$$$$V2.0`;await f(e,"C=CC(=C)SC[C@H](N)C(O)OC(C=CCCCCl)=CCC")}),(0,t.t6)("HelmPolymerWithComplexRGroups",async()=>{const e=`PEPTIDE1{[dI].[Trp_Ome].[Asp_OMe].[D-Cit].[meG].[Phe_4NH2].[Phe_34diCl].[meY].[Pro_4Me3OH].[Met_O].[NMe2Abz].[Tyr_Ph4OH].[3Pal].[xiIle].[Tyr_35diI].[Ala_tBu]}|PEPTIDE2{[${be.symbol}].[${we.symbol}]}$PEPTIDE1,PEPTIDE1,16:R2-1:R1|PEPTIDE1,PEPTIDE2,1:R3-1:R1$$$V2.0`;await f(e,"C=CSC[C@H](NCC[C@@H](C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](Cc2cc(I)c(O)c(I)c2)NC(=O)[C@H](C(C)CC)NC(=O)[C@H](Cc2cccnc2)NC(=O)[C@H](Cc2ccc(Oc3ccc(O)cc3)cc2)NC(=O)c2ccccc2N(C)C(=O)[C@H](CCS(C)=O)NC(=O)[C@@H]2C(O)C(C)CN2C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)CN(C)C(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC(=O)OC)NC(=O)[C@H](Cc2cn(OC)c3ccccc23)NC1=O)C(=O)N[C@@H](CSC(=C)C=C)C(O)OC(C=CCCCCl)=CCC")})});var Ae=n(8754);(0,t.L1)("toAtomicLevel-ui",()=>{let n,i,o,r,s;(0,t.gM)(async()=>{o=await(0,u.Q)(),s=await(0,fe.j)(),n=await(0,_.pj)(),i=await(0,D.u)(),await n.loadMonomerLibForTests(),r=n.getMonomerLib()}),(0,t.Pl)(async()=>{await(0,D.E)(i),await n.loadMonomerLib(!0)});const a={fasta:{src:{seq:"MDYKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},"fasta-with-gap":{src:{seq:"MD-YKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},helm:{src:{seq:"PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}},"helm-with-gap":{src:{seq:"PEPTIDE1{meI.hHis.*.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}}},h=async t=>{const n=t.src.seq,i=e.DataFrame.fromColumns([e.Column.fromList(e.COLUMN_TYPE.STRING,"seq",[n])]);return await l.data.detectSemanticTypes(i),i.getCol("seq")};for(const[e,n]of Object.entries(a))(0,t.t6)(`${e}-linear`,async()=>{const e=await h(n);await d(e,!1,n.tgt)});if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length)for(const[e,n]of Object.entries(a))(0,t.t6)(`${e}-nonlinear`,async()=>{const e=await h(n);await d(e,!0,n.tgt)});async function 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Se("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP",n)).getDistanceFunctionName();(0,t.E3)(e,Ee.Z.LEVENSHTEIN)}),(0,t.t6)("DNA-distance-function",async()=>{const e=(await Se("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA",n)).getDistanceFunctionName();(0,t.E3)(e,Ee.Z.LEVENSHTEIN)}),(0,t.t6)("MSA-distance-function",async()=>{const e=(await Se("seq\nATAACATAAC\nATCGAATCGA\nATCGAATCGA",n)).getDistanceFunctionName();(0,t.E3)(e,Ee.Z.HAMMING)}),(0,t.t6)("levenstein-sub",async()=>{const e=Ee.V[Ee.Z.LEVENSHTEIN]();Me(r,s,e,.2)}),(0,t.t6)("levenstein-del",async()=>{const e=Ee.V[Ee.Z.LEVENSHTEIN]();Me(a,l,e,.4)}),(0,t.t6)("hamming",async()=>{const e=Ee.V[Ee.Z.HAMMING]();Me(a,l,e,.6)}),(0,t.t6)("needleman-blosum62",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});Me(r,s,e,-6)}),(0,t.t6)("needleman-blosum62-del",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});Me(a,l,e,-3.667)}),(0,t.t6)("needleman-custom-sub",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});Me(r,s,e,.2)}),(0,t.t6)("needleman-custom-del",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});Me(a,l,e,.667)}),(0,t.t6)("needleman-custom-zero-extend",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:0});Me(c,h,e,.333)}),(0,t.t6)("needleman-custom-half-extend",async()=>{const e=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:2,gapExtend:1});Me(c,h,e,1.667)}),(0,t.t6)("needleman-custom-same-extend",async()=>{const t=Ee.V[Ee.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:i,alphabetIndexes:o,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?Me(Array(1e3).fill(c).join(""),Array(1e3).fill(h).join(""),t,1.333):Me(c,h,t,1.333)},{benchmark:!0})});var xe=n(684);async function Pe(n,i,o,r,s,a,c,u){await l.data.detectSemanticTypes(n),await l.functions.call("Bio:activityCliffs",{table:n,molecules:n.getCol(o),activities:n.getCol(r),similarity:s,methodName:i,similarityMetric:c,preprocessingFunction:u,options:{[`${xe.vb}`]:!0},demo:!1});const h=Array.from(l.shell.tv.viewers)[1];(0,t.E3)(h?.type===e.VIEWER.SCATTER_PLOT,!0),await(0,t.bk)(()=>{const e=Array.from(h.root.getElementsByClassName("scatter_plot_link"));return!e.length||e[0].innerText.toLowerCase()===`${a} cliffs`},"incorrect cliffs link",3e3)}var Ie=n(2780),Le=n(9039),_e=n(9124);async function Ne(n,i,o){const r=n.getCol(o);n.name="seqSpaceDf";const s=await l.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const a=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!a)throw new Error("Preprocessing function not found");await l.functions.call("Bio:sequenceSpaceTopMenu",{table:n,molecules:n.col(o),methodName:i,similarityMetric:Ee.Z.LEVENSHTEIN,plotEmbeddings:!0,preprocessingFunction:a,options:{[xe.vb]:!0}});const c=l.shell.tableView(n.name),u=Array.from(c?.viewers??[])[1];(0,t.E3)(null!=u)}(0,t.L1)("activityCliffs",async()=>{let n,i,o;const r=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],s=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)(async()=>{e.Func.find({package:"Helm",name:"getHelmHelper"}).length&&(n=await(0,_e.b2)()),i=await(0,_.pj)(),o=await(0,D.u)(),await i.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(o),await i.loadMonomerLib(!0)}),(0,t.t6)("activityCliffsOpens",async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_with_random_motif_1600.csv",tgt:{cliffCount:64}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await $(t.fileName);l.shell.addTableView(n),await Pe(n,Le.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,Ee.Z.LEVENSHTEIN,r)},{benchmark:!0,skipReason:"Fails"}),(0,t.t6)("activityCliffsWithEmptyRows",async()=>{const e=await $("tests/100_3_clustests_empty_vals.csv");l.shell.addTableView(e),await Pe(e,Le.c.UMAP,"sequence","Activity",90,3,Ee.Z.LEVENSHTEIN,r)}),(0,t.t6)("Helm",async()=>{if(e.Func.find({package:"Helm",name:"getHelmHelper"}).length){const e=await Re.files.readCsv("samples/HELM_50.csv");l.shell.addTableView(e),await Pe(e,Le.c.UMAP,"HELM","Activity",65,20,Ie.aT.Tanimoto,s)}})}),(0,t.L1)("sequenceSpace",async()=>{let n,i,o,r;(0,t.t6)("sequenceSpaceOpens",async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_with_random_motif_1600.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await $(t.fileName),i=l.shell.addTableView(n),await Ne(n,Le.c.UMAP,"sequence")},{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",async()=>{o=await $("tests/100_3_clustests_empty_vals.csv"),r=l.shell.addTableView(o),await Ne(o,Le.c.UMAP,"sequence")})}),(0,t.L1)("Scoring",()=>{const n="sequence",i="expected_similarity",o="expected_identity",r=e.DataFrame.fromCsv(`${n},${i},${o}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.691,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.37,0.0`),s=r.getCol(n);s.meta.units=c.Hi.HELM,s.semType=e.SEMTYPE.MACROMOLECULE;const a=s.get(0);let u,h;(0,t.gM)(async()=>{u=await(0,_.pj)(),h=await(0,D.u)(),await u.loadMonomerLibForTests()}),(0,t.Pl)(async()=>{await(0,D.E)(h),await u.loadMonomerLib(!0)}),(0,t.t6)("Identity",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:a});for(let n=0;n<e.length;n++){const i=e.get(n),s=r.get(o,n);(0,t.Wj)(i,s,.01,`Wrong identity score for sequence at position ${n}`)}}),(0,t.t6)("Identity-shortReference",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$"});(0,t.E3)(I().count(0).take(e.length).map(t=>e.get(t)).every(e=>null!=e&&!isNaN(e)),!0)}),(0,t.t6)("Identity-longReference",async()=>{const e=await l.functions.call("Bio:sequenceIdentityScoring",{table:r,macromolecule:s,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$"});(0,t.E3)(I().count(0).take(e.length).map(t=>e.get(t)).every(e=>null!=e&&!isNaN(e)),!0)}),(0,t.t6)("Similarity",async()=>{const e=await l.functions.call("Bio:sequenceSimilarityScoring",{table:r,macromolecule:s,reference:a});for(let n=0;n<e.length;n++){const o=e.get(n),s=r.get(i,n);(0,t.Wj)(o,s,.01,`Wrong similarity score for sequence at position ${n}`)}})});const Re=new e.Package;async function $e(n,i,o,r){const s=await(0,t.N$)({category:n,test:i,testContext:o,stressTest:r});return e.DataFrame.fromObjects(s)}async function Oe(){await(0,t.Xb)(Re,Re.getModule("package-test.js"))}})(),bio_test=i})();
8
8
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