npm - @datagrok/bio - Versions diffs - 2.25.0 → 2.25.2 - Mend

@datagrok/bio 2.25.0 → 2.25.2

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Files changed (17) hide show

package/CHANGELOG.md +14 -0
package/detectors.js +26 -12
package/dist/package-test.js +5 -5
package/dist/package-test.js.map +1 -1
package/dist/package.js +3 -3
package/dist/package.js.map +1 -1
package/package.json +2 -2
package/scripts/mol-to-helm.py +1279 -0
package/src/package-api.ts +14 -0
package/src/package.g.ts +9 -0
package/src/package.ts +27 -1
package/src/utils/monomer-lib/library-file-manager/ui.ts +23 -4
package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +34 -13
package/src/utils/seq-helper/seq-handler.ts +15 -6
package/src/widgets/sequence-scrolling-widget.ts +195 -183
package/test-console-output-1.log +774 -766
package/test-record-1.mp4 +0 -0

package/dist/package.js CHANGED Viewed

@@ -1,8 +1,8 @@
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+var bio;(()=>{var e={117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),o=n(5765),r=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,o.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=r.mergeEvaluated.props(t,(0,r.toHash)(u),c.props));const h=u.filter(e=>!(0,r.alwaysValidSchema)(c,n[e]));if(0===h.length)return;const d=t.name("valid");for(const n of h)p(n)?m(n):(t.if((0,o.propertyInData)(t,l,n,c.opts.ownProperties)),m(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function p(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const i=n(396),o=n(7887),r=n(8708),s=n(9029),a=n(4227);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(i.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l||(t.DataType=l={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:i,opts:r}=e,a=function(e,t){return t?e.filter(e=>u.has(e)||"array"===t&&"array"===e):[]}(t,r.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,o.schemaHasRulesForType)(e,t[0]));if(c){const o=d(t,i,r.strictNumbers,l.Wrong);n.if(o,()=>{a.length?function(e,t,n){const{gen:i,data:o,opts:r}=e,a=i.let("dataType",s._`typeof ${o}`),l=i.let("coerced",s._`undefined`);"array"===r.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${o}) && ${o}.length == 1`,()=>i.assign(o,s._`${o}[0]`).assign(a,s._`typeof ${o}`).if(d(t,o,r.strictNumbers),()=>i.assign(l,o))),i.if(s._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===r.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${o}`).elseIf(s._`${o} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${o} === null
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0!==t?t:e.message:e.toString()}var m=n(8070),g=n(7602),f=n(439),y=n(6882);var b=n(2020);function v(e,t,n){return Math.abs(e-t)<=n}var w,C,S=n(6307),A=n(6197);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class x{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class E{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const h=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,u,a*l,n),u+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){let c=a;const h=l.bounds,d=h.left;let m=y.S$;if(r)try{m=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,A.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){p(e)}const g=(0,u.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,h.top,h.width,h.height),e.fillStyle=m,e.textAlign="left",e.font=t;const f=e.measureText(g);e.setTransform(h.width/f.width,0,0,h.height/i,d,h.top),e.fillText(g,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,S.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var T;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(T||(T={}));const _=new class{render=20};class I extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. 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Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(T.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new h.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(u.gp.positionNames),t=this.seqCol.getTag(u.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(u.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(u.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new E(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=T.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null==l?i.width:Math.max(l,i.width),c=null==c?o:Math.max(c,o)}const h=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],u=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null==a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() 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o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - 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infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(t,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var e=arguments,t=null,n=-1;return new X(function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return 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n=n.next,{done:!1,value:e}}):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var h=r,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,r.undirected),e&&l)return u}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var he=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ue(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var h=o(c.key,c.attributes);if(e&&h)return c.key}}}function pe(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new ue;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function me(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),e&&u))return null}}function fe(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ue.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},ue.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Se={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),h=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);e._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,u.key=o,e.emit("edgeAdded",u),o}function Ee(e,t,n,i,o,r,s,l,h){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var f=[p.key,!1,!1,!1];if(h?!u:!l)return f;if(h){var y=p.attributes;p.attributes=u(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return f}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Ae(e,r,{}),v=!0,r===s&&(g=m,w=!0)),g||(g=Ae(e,s,{}),w=!0),d=new z(i,o,m,g,l),e._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,g.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,g.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Se,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?U:q;u(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return u(s(t),"_attributes",{}),u(s(t),"_nodes",new Map),u(s(t),"_edges",new Map),u(s(t),"_directedSize",0),u(s(t),"_undirectedSize",0),u(s(t),"_directedSelfLoopCount",0),u(s(t),"_undirectedSelfLoopCount",0),u(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),u(s(t),"_options",e),Ce.forEach(function(e){return u(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new W('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):G(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return h(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new D("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var h=r,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new D("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var m=s,g=m.source,f=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach(function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)}),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new W('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new W("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new W("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach(function(e,t){n[t]=e.attributes});var i={},o={};this._edges.forEach(function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var h="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[h]?o[h]=0:o[h]++,a+="".concat(o[h],". 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requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const p=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${u.b9}`,"kalign-version"),f=r.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),v=r.inputs([f,y,m]),w=r.button("Alignment parameters",()=>{v.hidden=!v.hidden,[f,y,m].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),v.hidden=!0,w.prepend(r.icons.settings(()=>null));const C=[p.root.style],S=[m.root.style,g.style];let A,x=d;const E=r.input.column("Sequence",{table:h,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(E.value=x);x=e,L.disabled=!1,A=await I(E.value,h,t,C,S,p,M,f,y,m,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});E.setTooltip("Sequences column to use for alignment");const M=r.input.column("Clusters",{table:h,value:e.clustersCol});M.nullable=!0;const T=r.dialog("MSA").add(E).add(M).add(p).add(v).add(w).add(b).add(g).onOK(async()=>{await _(E,h,A,n,a)}),L=T.getButton("OK");if(E.fireChanged(),e.col)return A=await I(e.col,h,t,C,S,p,M,f,y,m,b),void await _(E,h,A,n,a);T.show()})}async function _(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has 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L(r,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,g.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,o,i,d.value,m.value,g.value,p.value,void 0,y.value)}return m.value=null,g.value=null,f.value=null,void L(r,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),M._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(4954),p=n(4574),m=n(1757),g=n.n(m),f=n(9124),y=n(9192),b=n(4870),v=n(2020);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends p.O{emptyProps=new A("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new 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t=e.options.get(l.n3)??"",n=e.friendlyName??e.name,i=e.options.get(l.C0)??"",o=e.options.get(l._X)??"",r=e.options.get(l.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})}),this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,items:r.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings(()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)},"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings(()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)},"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let o=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,o=!0),o||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let h=!1;this.preprocessingFuncSettingsIcon=s.icons.settings(async()=>{h?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),h=!h},"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find(e=>!!this.columnFunctionsMap[e.name])??null,t=s.input.column("Column",{table:this.tableInput.value,value:e,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach(e=>this.colInputRoot.append(e)),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;if(!e)return;const t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach(e=>{Object.keys(this.supportedFunctions).forEach(t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))})}),this.regenerateColInput()};t(),R()(e.columns).some(e=>!!e.getTag(a.Tags.SemanticDetectionDuration))||e.meta.detectSemanticTypes().then(()=>{t()})}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach(e=>this.similarityMetricInputRoot.append(e)),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach(n=>{const i=t[n],o="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,s.tooltip.bind(o.input??o.root,i.disableTooltip??"")):s.tooltip.bind(o.input??o.root,i.tooltip)}),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find(e=>e.property.name===r.name);s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe(e=>{this.preprocessingFunctionSettings[r.name]=e}),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}}var k=n(9713),H=n(6295);const F=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class B{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),f=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),p=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(u.set(r,i),s<m&&(m=s),a>g&&(g=a),e())}})}await Promise.all(l),n&&u.forEach((e,t)=>{u[t]=(e-m)/(g-m)}),i(u)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)r[e]<m&&(l[p]=u[e],c[p]=d[e],h[p]=r[e],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach((e,t)=>r[t].threshold=o);const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:u,endIdx:p,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),h(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const p=await Promise.all(u),m=p.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(m),f=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),h=new Array(this._workerCount),u=e[0].length,d=e.map(e=>e[t]),p=Math.ceil(u/this._workerCount);for(let t=0;t<this._workerCount;t++)h[t]=new Promise((n,i)=>{const h=t*p,m=t===this._workerCount-1?u:(t+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(h,m)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const m=await Promise.all(h),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:h,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}});const d=await Promise.all(u),p=d.reduce((e,t)=>e+t.distance.length,0),m=new Float32Array(p);let g=0;for(const e of d)m.set(e.distance,g),g+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=F(e[l])||F(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,W,j=n(8774);(W=V||(V={})).none="none",W.bold="bold",W.dashed="dashed";class U{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new j.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,h,u,d,p,m,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const S=this.sp.pointToScreen(this.lines.to[e]);let A=null==S?void 0:S.x,x=null==S?void 0:S.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&A&&x&&Math.hypot(A-w,x-C)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[e])?null===(u=this.lines.widths)||void 0===u?void 0:u[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let S=null;if(b){t=this.getLineLength(w,C,A,x);const o=this.getPointOnDistance(w,C,A,x,i,t),r=this.getPointOnDistance(A,x,w,C,n,t);w=o.x,C=o.y,A=r.x,x=r.y,S=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,A,x,e):this.findControlPoint(b,A,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(S.x,S.y,A,x)}else(!this.lines.skipShortLines||Math.pow(A-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(A,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,A,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,A,x,i,t),n=b?S.x:w,o=b?S.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,h,u)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,h=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,h)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new j.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(e-a),g=Math.abs(t-p),f=m+g;(!d||d>f)&&(d=f),u[r]=Math.max(m,g),c[r]=a,h[r]=p}for(let e=0;e<c.length;e++)u[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,h[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const s=n-o*((n-e)/r),l=i-o*((i-t)/r);return new a.Point(s,l)}findControlPoint(e,t,n,i,o,r){const s=t+(i-t)/2,l=n+(o-n)/2;let c=s-t,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const q="dimensionality-reducer-terminate-event";var z,Y,K=n(3629);async function Z(e,t,i,o,s,a,l){let c=await async function(e,t,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q).subscribe(()=>{try{u?.terminate()}finally{d.unsubscribe()}});u.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{F(n)||F(i)?(d.unsubscribe(),e?h(e):c(t),setTimeout(()=>u.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,o,s,a,l);return c=c.map(e=>(0,K.S8)(e)),c}(Y=z||(z={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const X={[z.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[z.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return E(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==M))return null;let e=!1;if(T&&(T.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!T||e){const e=1e9,t=M.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return T=yield M.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),T}catch(e){return console.error("Failed to create device with required limits",e),T=yield M.requestDevice(),T}}return T})}();if(!s)return null;const a=Object.values(J);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(z).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,h=e[0].length,u=e.map((e,t)=>function(e,t=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!ne[s]||!ne[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const h=c.reduce((e,t)=>Math.max(e,t),0),u=te[t](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach((e,t)=>{p.set(e,t*h)});let m="",g=0,f="FLOAT32ARRAY",y=null;if(t===J.NEEDLEMAN_WUNSCH||t===J.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce((e,t)=>Math.min(e,t),p[0]),t=p.reduce((e,t)=>Math.max(e,t),p[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=z.MANHATTAN);let d=u.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*h);u.forEach((e,t)=>{g.set(e.arraySizes,t*h)});const f=1e4,y=100,b=u.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,S=h*(h-1)/2,A=Math.ceil(S/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${A} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,u.map(e=>e.maxEntryLen),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(S/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?S-1:(e+1)*R,n=h-2-Math.floor(Math.sqrt(-8*t+4*h*(h-1)-7)/2-.5),i=t-h*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce((e,t)=>e+t.sourceArraySize,0),H=u.reduce((e,t)=>e+t.suppInfoSize,0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const D=15&G;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let j=0;new Uint32Array(W,j,f).set(I),j+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,f).set(L),j+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,f).set(N),j+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,f).set(P),j+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g.length).set(g),j+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,j,c).set(o),j+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of u){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,j,n).set(e.flatSourceArray),j+=n*t.BYTES_PER_ELEMENT}V.unmap();const U=H*Uint32Array.BYTES_PER_ELEMENT;let q=U;const Y=15&U;0!==Y&&(q+=16-Y),q=Math.max(q,16);const K=s.createBuffer({label:"supp info buffer",size:q,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=K.getMappedRange();let X=0;for(const e of u)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(Z,X,e.suppInfoBuffer.length).set(e.suppInfoBuffer),X+=e.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ee=Q;const ie=15&Q;0!==ie&&(ee+=16-ie);const re=s.createBuffer({label:"results buffer",size:ee,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],he=[];let ue=!1;for(;!ue;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(_),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,F);o+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,ue=new Uint32Array(i,o,f).every(e=>1===e);const h=c.reduce((e,t)=>e+t,0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(u.set(r.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(u),ce.push(d),he.push(p),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),pe=new Uint32Array(de),me=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)pe.set(le[e],fe),me.set(ce[e],fe),ge.set(he[e],fe),fe+=le[e].length;return V.destroy(),K.destroy(),re.destroy(),ae.destroy(),{i:pe,j:me,distance:ge}})}function oe(e,t,n,i){return e.map((e,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${ee[e](t[i],i)}\n        }\n      `).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${e.length}>;\n        ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n        ${X[i](e.length)}\n      }\n    \n    `}let re=0;const se="cliffsDf",ae=new h.Subject,le="SALI",ce="line index",he=["From","To"],ue="filterCliffs";async function de(e,t,i,o,l,c,h,u,d,p,m,g,f,y,b,v,w){re++;const C=c/100;let S,A=!1;const x=g.inputs,E=await g.apply({[x[0].name]:t,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let M=[];if(u===N){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{u=e,h.onmessage=t=>{setTimeout(()=>h.terminate(),100),e(t.data.res)},h.onerror=e=>{setTimeout(()=>h.terminate(),100),t(e)}}),terminate:()=>{try{u(null),h.terminate()}catch(e){console.error(e)}}}}([E.entries],c,[1],"MANHATTAN",[h],[E.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),M=[t.embedX,t.embedY]}else M=await Z([E.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[E.options??{}]});if(M.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<M.length;++t)e.columns.addNewFloat(i[t]).init(e=>M[t][e]);let T=null;if(d.useWebGPU)try{T=await ie([E.entries],C,[h],z.MANHATTAN,[1],[E.options??{}])}catch(e){console.error(e)}T||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),T=await(new D).calc(E.entries,h,C,E.options));const _=await async function(e,t){const n=e.distance.map((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0}),i=e.distance.map(e=>1-e),o=e.i,r=e.j,s=a.BitSet.create(t.length);return e.distance.forEach((t,n)=>{s.set(e.i[n],!0),s.set(e.j[n],!0)}),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:s}}(T,l),I=function(e,t,n,i,o,r,s){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(s.get(i[e])>s.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return 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n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return he.forEach((e,t)=>{h.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(h.col(e),r),h.col(e).semType=o}),h.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),h.columns.addNewInt(ce).init(e=>e),h.columns.addNewFloat(le).init(e=>t.saliVals[e]),h.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),h.name=`${se}${re}`,{lines:c,linesDf:h}}(e,_,t,l,p,m,P,$);F.lines.skipMultiLineCalculation=!0,F.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const G=new 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e=0;e<F.linesDf.rowCount;e++)F.lines.widths[e]=e===F.linesDf.currentRowIdx?3:1;G.linesToRender=F.lines;const n=F.linesDf.currentCol&&F.linesDf.currentCol.name===he[1]?F.lines.to:F.lines.from,o=-1!==F.linesDf.currentRowIdx?F.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=F.linesDf.currentRowIdx;G.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,h=Math.min(l,c),u=e/h*5,d=t/h*5,p=(n<o?n:o)+s/2-u/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],F.lines.from[n]),H.dataFrame.get(i[1],F.lines.from[n]),H.dataFrame.get(i[0],F.lines.to[n]),H.dataFrame.get(i[1],F.lines.to[n]));H.zoom(a,h,c,u),j.value?e.filter.and(L):!0===j.enabled&&e.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,o,a,l,c,h){const u=t.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:o,df:e,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout(()=>{r.shell.o=t.root},500)}(e,S,F.lines.from[o],F.lines.to[o],o,t,l,F.linesDf.get(le,o),y);const n=H.dataFrame.getSortedOrder(O.grid.sortByColumns,O.grid.sortTypes);O.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))},1e3)}}),F.linesDf.onSelectionChanged.subscribe(t=>{setTimeout(()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<F.linesDf.rowCount;e++){const n=F.linesDf.selection.get(e);n&&(t.set(F.lines.from[e],!0),t.set(F.lines.to[e],!0)),F.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),G.linesToRender=F.lines})(),100)}),e.onSelectionChanged.subscribe(t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<F.lines.colors.length;e++)F.lines.colors[e]="0,128,0";G.linesToRender=F.lines})(B.dataFrame))}),G.lineClicked.subscribe(t=>{if(A=!0,G.currentLineId=t.id,-1!==t.id){const n=F.linesDf.selection.clone();setTimeout(()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),F.linesDf.selection.copyFrom(n)):(F.linesDf.currentRowIdx!==t.id&&(F.linesDf.currentRowIdx=t.id,e.currentRowIdx=F.lines.from[t.id]),F.linesDf.selection.copyFrom(n));const i=F.linesDf.getSortedOrder(B.sortByColumns,B.sortTypes);B.scrollToCell(he[0],i.indexOf(t.id))},500)}}),G.lineHover.pipe((0,k.debounceTime)(500)).subscribe(n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(f({lineId:n.id,points:[F.lines.from[n.id],F.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)}),H.addProperty("similarityLimit","double",C),S=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",()=>s.divText("Cliff has not been selected"),!0),r.shell.o=e.root,e}(),H}var pe=n(6863),me=n(2003),ge=n(3516),fe=n(3151);function ye(e,t){const n=e=>o[e]??null,i=e=>{const t=s.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,s=a.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getCanonical(o);(n(o)||i(o)).set(e,r,!1)}}return s}var be,ve=n(439),we=n(4971);async function Ce(e){const t=(await(0,we.pj)()).getMonomerLib(),n=[],i={},o=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),s=a.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){i[e[t]]=t;const a=o[t],l=""===a?new Array(o.length).fill(0):(await r.chem.getSimilarities(s,a)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(be||(be={}));var Se=n(9192);class Ae{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class xe extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ae}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ee,Me,Te;function _e(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Ie(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Le(e,t,i,o,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==h.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??r.shell.tableView(e.name)??r.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let S;try{const A=_e(e);function x(n,o,r){let c=null,h=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),h=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),h=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!S&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Ie(t,i)}))),g[l.YP]&&(S?.root&&s.setUpdateIndicator(S.root,!1),c.init(e=>r[0]?r[0][e]:void 0),h.init(e=>r[1]?r[1][e]:void 0));const u=n/o*100;C.update(u,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function E(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Ie(t,i)}),s.setUpdateIndicator(S.root,!0));const p=r.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&S?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===S?.getOptions()?.look?.title&&(r.events.fireCustomEvent(q,{}),p.unsubscribe(),n?.(),C.close())}),f=new Promise(async(r,s)=>{try{n=r;const s=[];let a=o,d=c,p=u;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<h.length;++e){const n=h[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[r]:o[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map(e=>e.entries),i,a,d,u,m,g[l.vb]?void 0:x))}catch(e){s(e)}}),y=await f;return C.close(),p.unsubscribe(),y}const M=await E();if(p&&M){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(M[0],M[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>_[e].toString()),S&&(S.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(M){const N=e.columns.byName(A[0]),P=e.columns.byName(A[1]);if(N.init(e=>M[0][e]),P.init(e=>M[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){r.shell.error("Post-processing failed"),console.error(O)}if(S)return s.setUpdateIndicator(S.root,!1),S.helpUrl="/help/compute/sequence-space",S}}catch(k){r.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),S&&s.setUpdateIndicator(S.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ee||(Ee={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Me||(Me={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Te||(Te={})),Object.prototype.toString;var Ne=n(6873),Pe=n(4356),Re=n(6717),$e=n(4025),Oe=n(4870),ke=n(3856),He=n(6882),Fe=n(7278),Ge=n(5553),Be=n(6642),De=n(3599),Ve=n(673),We=n(8312);class je extends Be.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,Dr.logger),(0,we.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,We.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ue=n(4139);const qe=me.zS;function ze(e){const t=!R().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class Ye extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=Dr.seqHelper}getRendererBack(e){const[t,n,i]=(0,Be.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Ge.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,Be.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(Dr.properties?Dr.properties.maxMonomerLength:4)??50;if(ke.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(ke.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new He.Jy(a,l,Dr.logger,d,()=>{const{font:e,fontWidth:t}=He.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:u.isMsa()?8:0,monomerToShort:qe}}),l.temp[".mm.cellRenderer.settingsChanged"],Ve.s.true,p.init().then(()=>{})),p.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class Ke extends je{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[me.gp.separator],u=this.tableCol.meta.units;i=(0,He.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[$e.j.notationProvider]?.separatorSplitter??(0,Fe.Iv)(u,h),g=m(d),f=m(p),y=R().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=R().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),v=this.tableCol.getTag(me.gp.alphabet);Xe(e,t,n,i,o,y,b,v===me.YI.RNA||v===me.YI.DNA?De.o.NUCLEOTIDE:De.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Be.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new Ke(t,n)),o}}class Ze extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ue.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){Ke.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Xe(e,t,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ve.b9[me.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const u=e.measureText(ze(r).join("")),d=e.measureText(ze(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,e.canvas.width=p+4*r.length);let m=Math.max(t,t+(i-(p+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const u=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=He.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=He.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,ke.oZ)(e,n,m,g-u,i,o,{color:d,pivot:0,left:!0}),p=(0,ke.oZ)(e,c,m,g+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[t]=Je(n,c,d,r,g,u,o))}else m=(0,ke.oZ)(e,n,m,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Je(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(ze([e]).join("")).width,h=l.measureText(ze([t]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,ke.oZ)(l,e,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,ke.oZ)(l,t,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Qe,et=n(8070),tt=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Qe||(Qe={}));const nt=new class{constructor(){this.regionTypes=[Qe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=tt.fH.Entropy,this.filterSource=tt.Fo.filterSource}};var it=n(7602),ot=n(250);const rt=Qe;var st,at;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(st||(st={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(at||(at={}));const lt=nt;class ct extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(at.skipEmptyPositions,lt.skipEmptyPositions,{category:st.DATA}),this.regionTypes=this.stringList(at.regionTypes,lt.regionTypes,{category:st.DATA,choices:Object.values(rt).filter(e=>e!=rt.Unknown)}),this.chains=this.stringList(at.chains,lt.chains,{category:st.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(at.fitWidth,lt.fitWidth,{category:st.LAYOUT}),this.positionWidth=this.float(at.positionWidth,lt.positionWidth,{category:st.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(at.positionHeight,lt.positionHeight,{category:st.LAYOUT,choices:Object.keys(tt.fH)}),this.filterSource=this.string(at.filterSource,lt.filterSource,{category:st.BEHAVIOR,choices:Object.values(tt.lT)}),this.viewSyncer=new it.g(Dr.logger)}static viewerCounter=-1;viewerId=++ct.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case at.regionTypes:case at.chains:this.setData(this.regions)}switch(e.name){case at.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case at.fitWidth:case at.positionWidth:this.calcSize();break;case at.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.positionHeight]:this.positionHeight});this.calcSize();break;case at.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;Dr.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){Dr.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){Dr.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=s.table(this.chains,e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(tt.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Dr.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Dr.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[ot.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(at.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[ot.n5.filterSource]:this.filterSource})}}})}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,et.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class ht{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ut{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new ut(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ht);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ht);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function pt(e,t,n="Morgan",i=1,o=.6){const r=e.length,s=Dr.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const h=new Map,u=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==u[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=s.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);h.has(i)||(h.set(i,String.fromCharCode(c)),c++),l[t]+=h.get(i)}}let p={};if(t===pe.Z.MONOMER_CHEMICAL_DISTANCE||t===pe.Z.NEEDLEMANN_WUNSCH){const e=Array.from(h.keys()),r=await async function(e,t="Morgan"){const n=(await(0,we.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),s=a.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!s)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await Ce(e);const l=a.Column.fromStrings("smiles",r),c=(a.DataFrame.fromColumns([l]),(await s.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await Ce(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,H.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),s={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{s[h.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);p={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:c},t===pe.Z.NEEDLEMANN_WUNSCH&&(p.gapOpen=i,p.gapExtend=o)}return{seqList:l,options:p}}var mt=n(4954);function gt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))}),t}function ft(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=Dr.seqHelper.getSeqHandler(e.seqCol),r=o.defaultBiotype,a=bt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),r,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(vt(i)),t.append(yt("Activity delta",Math.abs(n[0]-n[1]))),t.append(yt("Cliff",e.sali)),t}function yt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function bt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=Dr.monomerLib;return Xe(r,0,0,0,30,R().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),R().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function vt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function wt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(me.gp.separator,e.col(t[0]).getTag(me.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class Ct extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class St extends Ct{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[pe.Z.NEEDLEMANN_WUNSCH,pe.Z.HAMMING,pe.Z.LEVENSHTEIN,pe.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,me.gp.aligned,me.gp.separator,me.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",pe.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===pe.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===pe.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===pe.Z.NEEDLEMANN_WUNSCH}}const At={gapPenalty:1,matchScore:1,gapSymbol:ve.b9[ve.Hi.FASTA],localAlignment:!1};class xt extends St{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Oe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Oe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await pt(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new D).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=a.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(e.currentRowIdx),u=function(e,t,n={}){const i={...At,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let h=i.localAlignment?c[0]:r,u=i.localAlignment?c[1]:s,d=new Array(0),p=new Array(0);for(;h>0&&u>0;){const n=Math.max(a[h-1][u-1],a[h-1][u],a[h][u-1]);a[h][u]==a[h-1][u-1]+i.matchScore&&n==a[h-1][u-1]?(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1):a[h][u]==a[h-1][u]-i.gapPenalty?(p.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):a[h][u]==a[h][u-1]-i.gapPenalty?(d.push(i.gapSymbol),p.push(t.getCanonical(u-1)),u-=1):(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1)}d=[...R().count(0).take(h).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?R().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],p=[...R().count(0).take(u).map(e=>t.getCanonical(e)),...p.reverse(),...i.localAlignment?R().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const m=h,g=u;return m>g?p=[...new Array(m-g).fill(i.gapSymbol.valueOf()),...p]:d=[...new Array(g-m).fill(i.gapSymbol.valueOf()),...d],p.length>d.length?d.push(...new Array(p.length-d.length).fill(i.gapSymbol.valueOf())):p.push(...new Array(d.length-p.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:p.join(""),seq1Splitted:new Fe.Mu(d,i.gapSymbol),seq2Splitted:new Fe.Mu(p,i.gapSymbol)}}(c,h),d=bt(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(vt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",()=>t,!0),r.shell.o=p.root}}class Et extends St{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Oe.Kd)(i,t.name,450,30),(0,Oe.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await pt(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new B(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,h=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),u=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[h(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Mt,Tt=n(5433),_t=n(3890),It=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(Mt||(Mt={}));class Lt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Nt extends Lt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends Nt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(Mt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(Mt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(Mt.TYPE)&&-1!==e.indexOf(Mt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Mt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Mt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Mt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Mt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Mt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Mt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt extends Nt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Pt(e);if($t.isMolfileV3K(e))return new Rt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return Rt.isValidMolfile(e)}}var Ot=n(6197),kt=n(9124),Ht=n(3527);class Ft{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Ft.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Gt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Bt extends Ft{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Dt extends Ft{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Vt extends Ft{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Wt extends Ft{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class jt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Wt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new jt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Ut={[De.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[De.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[De.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[De.o.CHEM]:{R:"#eeeeee"},[De.o.BLOB]:{B:"#999999",G:"#e2e2e2"}};class qt{constructor(e,t=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=s.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],r={};let l=null;for(const c of this.properties){void 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o;c=s.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const zt={A:new j.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new j.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new j.A(new 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new j.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Yt[t])return null;const o=Yt[t];let r=0,s=null;for(const[e,t]of Object.entries(o)){const o=(0,H.$1)(i,t);o>r&&o>=n&&(r=o,s=e)}return s}var Zt,Xt=n(857),Jt={};Jt.styleTagTransform=S(),Jt.setAttributes=b(),Jt.insert=f().bind(null,"head"),Jt.domAPI=m(),Jt.insertStyleElement=w(),d()(Xt.A,Jt),Xt.A&&Xt.A.locals&&Xt.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Zt||(Zt={}));const Qt={[Zt.MONOMER]:a.COLUMN_TYPE.STRING,[Zt.SYMBOL]:a.COLUMN_TYPE.STRING,[Zt.NAME]:a.COLUMN_TYPE.STRING,[Zt.R_GROUPS]:a.COLUMN_TYPE.STRING,[Zt.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Zt.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Zt.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Zt.AUTHOR]:a.COLUMN_TYPE.STRING,[Zt.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Zt.ID]:a.COLUMN_TYPE.INT,[Zt.META]:a.COLUMN_TYPE.STRING,[Zt.SOURCE]:a.COLUMN_TYPE.STRING};async function en(e){const t=await tn(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>dn(t.rows.get(n))))}async function tn(e){try{const t=a.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Qt))if(t.columns.addNew(e,n),e===Zt.R_GROUPS)for(const e of i)t.columns.addNew(e,a.COLUMN_TYPE.STRING);t.col(Zt.SYMBOL).semType="Monomer",t.col(Zt.SYMBOL).setTag(ke.Mn.applyToBackground,"true"),t.col(Zt.SYMBOL).setTag(ve.qE.polymerTypeColumnName,Zt.POLYMER_TYPE);const o=a.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=cn(e[n].rgroups,e[n].smiles,e[n].molfile);o=on(o),e[n].rgroups=an(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?sn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(Zt.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(Zt.MONOMER).semType=a.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=a.SEMTYPE.MOLECULE}),t}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}}class nn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Zt.NAME).width=100,this.tv.grid.col(Zt.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=fe.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new ln(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(Zt.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await Hn.getInstance();await e.awaitLoaded(),this.instance=new nn(e)}return this.instance}static async getNewInstance(){const e=await Hn.getInstance();return await e.awaitLoaded(),new nn(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const o=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,o),await this.monomerLibManamger.loadMonomerLib(!1),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=s.input.choice("Storage",{items:o,value:o[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===o.length&&(a.readOnly=!0);const l=s.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)r.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){r.shell.error("Error creating library"),console.error(e)}l.close()}else r.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=r.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>dn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>dn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await dn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter(e=>e.name===nn.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(r.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?r.shell.v=e:nn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){r.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const o=s.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=s.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=s.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),h=s.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>dn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await dn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});s.tooltip.bind(h,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const u=s.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return r.shell.error("No library selected");let t=null;try{const n=await(0,we.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return r.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=nn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await dn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,we.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return r.shell.error(`Library ${e} not found`),a.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await tn(i)}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,we.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>dn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function on(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const rn=["alternateId","capGroupName","capGroupSMILES","label"];function sn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function an(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(rn,e),n=sn(t,"capGroupSMILES"),i=sn(t,"alternateId"),o=sn(t,"capGroupName"),r=sn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class ln{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new pn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",async()=>{const e=this.validateInputs();e?r.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=cn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Kt(un(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new qt(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?r.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new qt(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=an(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&Kt(un(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=cn(e.rgroups,e.smiles,e.molfile),n=r.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,we.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void r.shell.error(`Library ${t} not found in any provider`);const o=s.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=s.dialog("Remove Monomer"+(a?"s":"")).add(s.h1(l)).add(o).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void r.shell.error("No monomer library loaded");const i=n?.col(Zt.POLYMER_TYPE)?.toList()??[],o=n?.col(Zt.SYMBOL)?.toList()??[],a=n?.col(Zt.MONOMER)?.toList()??[];if(i.length!==o.length||i.length!==a.length)return void r.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&o[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),h=async()=>{try{const n=await(0,we.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void r.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,r.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){r.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let u=null,d="";if(l>=0)u=this.getMonomerInfoTable(await dn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await dn(this.getMonomersDataFrame().rows.get(c));u=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(u){const e=s.dialog("Save Monomer").add(s.divText(d)).add(u).addButton("Save",()=>{e.close(),h()}).show()}else await h()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!r.chem.checkSmiles(e))return void r.shell.warning("Invalid SMILES");e=cn([],e);let t=r.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=hn(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function cn(e,t,n){const i=!t||!r.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(o,e),o=on(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function hn(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function un(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=sn(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)}),n}async function dn(e){let t;try{t=JSON.parse(e.get(Zt.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Zt.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=hn(i)}catch(e){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Zt.NATURAL_ANALOG);const s=e.get(Zt.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Zt.R_GROUPS)??"[]"),!o&&s){const e=await Kt(un(n,l),s);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Zt.SYMBOL),name:e.get(Zt.NAME),molfile:i,smiles:n,polymerType:s,monomerType:e.get(Zt.MONOMER_TYPE),naturalAnalog:o,id:e.get(Zt.ID),rgroups:l,meta:t,author:e.get(Zt.AUTHOR),createDate:e.get(Zt.CREATE_DATE)}}class pn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}const mn=/.*\|\$.*R.*\$\|/,gn=/\[R(\d+)\]/,fn=/\[R(\d+)\]/g,yn=/\[\*:(\d+)\]/g;function bn(e,t){const n=Array.from(e.matchAll(fn)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=hn(r.chem.convert(t,r.chem.Notation.Smiles,r.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){Dr.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const vn=/[\w()]+/,wn=RegExp(String.raw`\(${vn}(,${vn})+\)`),Cn=e=>{const t=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,t,e),t},Sn=new Ht.Mi([255,255,255]),An=new Ht.Mi([0,0,0]),xn=.7*(0,K.wQ)(Sn);class En{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]);return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==ve._S||t===ve.b9[ve.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(mn.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return bn(a,t)}let n=e;const i=Array.from(e.matchAll(yn));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(gn.test(n))return bn(n,t)}catch(t){Dr.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Gt((0,Fe.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];i=t?.[n]??null}else{Dr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,kt.fA)(e,t),o=(0,Ot.Y)(n);let r=this.getMonomer(o,i);if(r&&n==De.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==De.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ve._S||"*"==i?s=r.wem=new Bt(n):n===De.o.NUCLEOTIDE&&"N"===i||n===De.o.AA&&"X"===i||(De.o.CHEM,0)||wn.test(i)?s=r.wem=new Dt(n,i):r.lib||(s=r.wem=new Vt(n,i,this.isEmpty)),s||(s=r.wem=jt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Ot.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),r=this.getMonomer(n,t);if(r){const e=r.symbol,[t,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?Cn(r.molfile):r.smiles?s.divV([Cn(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=ve._S){let e=r.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(e))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Ht.Mi([...o.map(e=>e+1)]),s=(0,K.KE)(r,Sn)/((0,K.wQ)(r)*(0,K.wQ)(Sn)),l=i(n.backgroundcolor),c=new Ht.Mi([...l.map(e=>e+.01)]);let h;h=(0,K.KE)(c,Sn)/((0,K.wQ)(c)*(0,K.wQ)(Sn))<s?l:o;let u=new Ht.Mi(h);const d=(0,K.wQ)(u);return d>xn&&(u=(0,K.dC)(An,u,xn/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Ot.Y)(e),r=this.getMonomer(o,t);let s;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){Dr.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(s=e[i])}if(!s){const t=Ut[e],n=t?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!s&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Mn=n(5488),Tn={};Tn.styleTagTransform=S(),Tn.setAttributes=b(),Tn.insert=f().bind(null,"head"),Tn.domAPI=m(),Tn.insertStyleElement=w(),d()(Mn.A,Tn),Mn.A&&Mn.A.locals&&Mn.A.locals;class _n extends En{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,Ot.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Pe.ub)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new In(e,`override: ${++_n.overrideCounter}, ${t}`,this)}}class In extends En{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Ln=n(8604),Nn=n(7433),Pn=n.n(Nn),Rn=n(1913),$n=n.n(Rn);class On{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Pn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});$n()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class kn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=we.ic;_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await r.dapi.files.readAsText(kn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),o=new On(i);kn._instance=new kn(o,e,t),kn._instance.refreshLists()}return kn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await r.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await r.dapi.files.exists(this.LIB_PATH+`${e}`)?r.shell.info(`Added ${e} HELM library`):r.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),r.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),o=[];for(let e=0;e<i.length;e++){const t={};try{const o=await r.dapi.files.readAsText(i[e]);n=JSON.parse(o),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{o.push(t)}}return o}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,o=this.SETS_PATH+e;try{const e=await r.dapi.files.readAsText(o),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new we.lH(n,i,o,r,s)});t.push(new we.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${o}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,o=await r.dapi.files.readAsText(i);let s=JSON.parse(o);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await r.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return r.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,o=await r.dapi.files.readAsText(i),s=JSON.parse(o);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await r.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await r.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}class Hn{logger;_monomerLib=new _n({},"MAIN");_monomerSets=new we.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new h.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new h.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new h.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await(0,et.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=a.Func.find({tags:["monomer-lib-provider"]});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await kn.getInstance(this,Dr.logger)),a.debounce((0,h.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Hn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Hn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Pe.ub)(),i=await this.getProviders(),o=await Promise.all(i.map(async e=>e.listLibraries()));o.forEach((e,n)=>{o[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=o[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new _n(e[t],l[t]))}catch(e){r.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let o=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){r.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++o/t.length),`Loading monomer sets ${o}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Pe.Eu)(Ln.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new _n(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===we.ic);if(!t)throw new Error(`Provider '${we.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new _n(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,we.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new Hn(Dr.logger))()),e}}var Fn=n(1757),Gn=n.n(Fn);class Bn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Dn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Bn(e));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,e),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Vn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Vn._instance||(Vn._instance=new Vn,await Vn._instance.refresh(),(await Hn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Vn._instance.refresh())),Vn._instance.refresh(),Vn._instance}async refresh(){this.settings=await(0,Pe.ub)();const e=await Hn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Dn(n,this.monomers[t][n],o,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Pe.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=s.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void r.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void r.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=s.input.choice("Default Library",{items:n,nullable:!0});s.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Pe.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else r.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=s.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Wn=n(3017),jn={};async function Un(){await Zn.showDialog()}async function qn(e=!0){return await Xn.showView(e)}jn.styleTagTransform=S(),jn.setAttributes=b(),jn.insert=f().bind(null,"head"),jn.domAPI=m(),jn.insertStyleElement=w(),d()(Wn.A,jn),Wn.A&&Wn.A.locals&&Wn.A.locals;class zn{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==zn.instancePromise&&(zn.instancePromise=(async()=>{const e=new zn,t=await(0,we.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),zn.instancePromise}static async reloadWidget(){const e=await zn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,we.pj)()).fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new a.Widget(e)}async getWidgetContent(){const e=await Yn.createControlsForm();return Gn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&Gn()(e)&&Gn()(e).removeClass("ui-form-condensed")},200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=await e.text(),i=e.name,o=a.TaskBarProgressIndicator.create(`Adding ${i} as a monomer library`);try{await t.addOrUpdateLibraryString(i,n)}catch(e){r.shell.error(`File ${i} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{o.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void r.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=s.dialog("Select storage for new monomer library"),o=s.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(o).onOK(async()=>{const e=n.find(e=>e.name===o.value);await t(e)})}})}}class Yn{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Dr.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Pe.ub)(),t=await(0,we.pj)();return new Yn(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=s.wideForm(e,void 0);return Gn()(t).addClass("monomer-lib-controls-form"),t}async updateControlsForm(){const e=await this._createControlsForm();Gn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;Dr.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{Kn(i.value,e)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const o=s.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=s.icons.edit(async()=>{r.shell.v=await(await nn.getInstance()).getViewRoot(e)},"Edit monomer library");return s.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),Dr.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await Kn(!1,e);const n=await(0,we.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),r.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function Kn(e,t){const n=await(0,Pe.ub)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Pe.Eu)(n);const i=await(0,we.pj)();await i.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class Zn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){Zn._instance||(Zn._instance=new Zn,Zn._instance.closeDialogSubject$.subscribe(()=>{Zn._instance.dialog=void 0})),Zn._instance.dialog||(Zn._instance.dialog=await Zn._instance.getDialog()),Zn._instance.dialog.show()}async getDialog(){const e=(await zn.getInstance()).widget,t=await(0,we.pj)(),n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Gn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class Xn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await zn.getInstance()).widget,n=s.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=s.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),o=s.splitH([s.divV([t.root,s.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(o),this._view.name=Xn.viewName,e&&r.shell.addView(this._view),s.tools.waitForElementInDom(o).then(()=>{setTimeout(()=>{const e=Array.from(o.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;t.style.width=`${r}px`;const s=i-r;n.style.width=`${s}px`},100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe(()=>{try{const e=Xn._instance;e&&e._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return Xn._instance||(Xn._instance=new Xn),Xn._instance._duplicateManager||(Xn._instance._duplicateManager=await Vn.getInstance()),Xn._instance.libManager||(Xn._instance.libManager=await Hn.getInstance()),e&&Xn._instance._view&&Array.from(r.shell.views).find(e=>e.id&&e.id===Xn._instance._view.id)?(r.shell.v=Xn._instance._view,await Xn._instance._duplicateManager.refresh(),Xn._instance._view):(Xn.closeExistingViews(),Xn._instance.getView(e))}static closeExistingViews(){Array.from(r.shell.views).filter(e=>e.name===Xn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await Hn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(c);const h=await this.libManager.getProviders();if(0===h.length)return void r.shell.error("No monomer library providers available to save the merged library.");const u=s.input.choice("Storage",{items:h.map(e=>e.name),value:h[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(u).add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{a.Utils.download((()=>{let e=o.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!o.value||!o.value.trim()||!u.value)return u.validate(),void o.validate();i.close();const e=o.value,t=JSON.stringify(n);this._view&&s.setUpdateIndicator(this._view.root,!0);try{const n=h.find(e=>e.name===u.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Pe.ub)();i.exclude=l,await(0,Pe.Eu)(i),await this.libManager.loadMonomerLib(!0),await zn.reloadWidget()}catch(t){r.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Jn,Qn=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ei{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe(e=>Qn(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=r.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),()=>Qn(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),()=>Qn(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),()=>Qn(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,ei.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Qn(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,et.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return Qn(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Qn(this,void 0,void 0,function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Qn(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return Qn(this,void 0,void 0,function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ei.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Qn(this,void 0,void 0,function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ei.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Jn||(Jn={}));var ti=n(966),ni=n(608),ii=n(1619);class oi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Dr.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case ot.n5.fixWidth:case ot.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ri{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var si=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ai="-";class li extends je{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(ke.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ve._S||(a=ai);const l=a.split(ve.ot).map(e=>e&&e!==ve._S?e.trim():ai),c=l.map(e=>(0,me.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),h=c.map(t=>e.measureText(t).width),u=h.reduce((e,t)=>e+t,0);let d=t+(i-u)/2;const p=this.tableCol.getTag(ve.gp.alphabet),m=p===me.YI.RNA||p===me.YI.DNA?si.o.NUCLEOTIDE:si.o.AA;for(let a=0;a<c.length;a++){const u=l[a],p=this.getHelmType(r,m);let g=He.S$,f="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(p,u);g=e?.textcolor??g,f=e?.backgroundcolor??f}else g=this.monomerLib.getMonomerTextColor(p,u);s&&1==l.length&&(e.fillStyle=f,e.fillRect(t,n,i,o)),e.fillStyle=g,e.fillText(c[a],d,n+o/2,i),d+=h[a]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(ve.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),r=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==ve._S||i==ai)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===me.YI.RNA||n===me.YI.DNA?si.o.NUCLEOTIDE:si.o.AA,c=i.split(ve.ot).map(t=>{if(!t||t===ve._S||t===ai)return s.divText("gap");const n=this.getHelmType(e,l);return this.monomerLib.getTooltip(n,t)}),h=s.divH(c,{style:{alignItems:"top"}}),u=Array.from(h.querySelectorAll("canvas"));if(u.length>2){const e=Math.floor(550/u.length);u.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return s.tooltip.show(h,r,a),!0}getHelmType(e,t){let n=t;if((e.tableRowIndex??-1)>-1&&e.tableColumn?.getTag(ve.qE.polymerTypeColumnName)){const t=e.tableColumn.getTag(ve.qE.polymerTypeColumnName),i=e.tableColumn.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,Fe.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Be.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new li(t,n)),o}}class ci extends a.GridCellRenderer{get name(){return Ue.uF.MONOMER}get cellType(){return Ue.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){li.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){li.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class hi{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ui extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class di extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new hi(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Se.AP)(e);r.shell.error(t),this.logger.error(t,void 0,n)}}var pi=n(6307),mi=n(5999),gi={};gi.styleTagTransform=S(),gi.setAttributes=b(),gi.insert=f().bind(null,"head"),gi.domAPI=m(),gi.insertStyleElement=w(),d()(mi.A,gi),mi.A&&mi.A.locals&&mi.A.locals;class fi extends a.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=Dr.properties.tooltipWebLogo,n=this.seqCol.getTag(tt.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function yi(e,t,n,i){const o=Dr.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const bi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(me.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class vi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??bi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(me.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(me.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Dr.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class wi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(me.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{Dr.handleErrorUI(e)})}).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=s.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{Dr.handleErrorUI(e)})});return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var Ci=n(8754);async function Si(e,t,n,i,o){const s=await async function(e,t,n,i,o){const s=ye(t,o),l=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=o.getSeqHandler(l).getSplitted(0),h=i===be.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ve._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return s}(c,s):i===be.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),o=await async function(e,t,n){e instanceof a.Column&&(e=ye(e,n).columns.toList());const i=(await(0,we.pj)()).getMonomerLib(),o=new Array(e.length),s=e[0].length,l=new Float32Array(s);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):ve._S,h=i.getMonomer("PEPTIDE",c)?.smiles??"",u=e[n],d=u.getRawData(),p=u.categories,m=p.indexOf("");if(o[n]={categories:p,data:d,emptyIndex:m},void 0===c)continue;const g=a.Column.fromStrings("smiles",p.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),f=(a.DataFrame.fromColumns([g]),await r.chem.getSimilarities(g,h)),y=f?f.getRawData():null;for(let e=0;e<s;++e){const t=d[e];c!==ve._S&&t!==m?l[e]+=y[t]:c===ve._S&&t===m&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let r=0;r<e.length;++r){const e=o[r];if(r>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&r<t.length){i=a.FLOAT_NULL;break}}l[n]=i}return a.Column.fromFloat32Array("Similarity",l)}(i,e,n);return o}(c,s,o):null;if(null===h)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return h.name=e.columns.getUnusedName(h.name),e.columns.add(h),h}(e,t,n,i,o);for(let e=0;e<s.length;e++)t.isNone(e)&&s.set(e,null,!1);return s}var Ai=n(294),xi=n(330);const Ei=OCL;var Mi=n(2582);class Ti{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var _i=n(6956);class Ii{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach((t,n)=>{const i=e[n-1];i===_i.m?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)})}}class Li{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Ni extends Li{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class Pi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ri extends Pi{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class $i extends Ti{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Ni(n),this.bonds=new Ri(n),this.rGroups=new Ii(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Oi extends Li{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class ki extends Pi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Hi extends Ti{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Oi(n),this.bonds=new ki(n),this.rGroups=new Ii(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Fi{static getInstance(e,t){if($t.isMolfileV2K(e))return new $i(e,t);if($t.isMolfileV3K(e))return new Hi(e,t);throw new Error("Unsupported molfile version")}}class Gi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Fi.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Gi.molfileV2KToV3KCache.has(e))return Gi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Gi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map(e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,""))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Bi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Mi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ve.b9[me.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Gi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Ai.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?De.o.NUCLEOTIDE:De.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(r).take(n.atomCount).toArray(),bonds:R().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END BOND"].join("\n")}}class Di{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Vi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Ei.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,Se.AP)(e);return Dr.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),s=`molfile(${e.name})`,l=o?o.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,xi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Ai.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,Se.AP)(e);Dr.logger.error(t,void 0,n),o=Ai.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Di(o),s=new Bi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Ai.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Ai.vF(a.molfile,l)}}var Wi=n(2738);class ji{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[$e.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[$e.j.notationProvider]??null);const i=this.isFasta()?ve.b9[me.Hi.FASTA]:this.isSeparator()?ve.b9[me.Hi.SEPARATOR]:this.isHelm()?ve.b9[me.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ve.b9[me.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(me.gp.aligned)||!this.column.tags.has(me.gp.alphabet)||!this.column.tags.has(me.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===me.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(me.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(me.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(me.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${me.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=a.Func.find({tags:["notationRefiner"]});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[$e.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([me.Hi.FASTA,me.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(me.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(me.gp.aligned);null==t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(me.gp.aligned,t));let n=e.column.getTag(me.gp.alphabet);if(null==n&&(n=(0,Fe.pc)(e.stats.freq,me.q7),e.column.setTag(me.gp.alphabet,n)),n===me.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(me.gp.alphabetSize,t.toString()),e.column.setTag(me.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===me.Hi.HELM){let t=e.column.getTag(me.gp.alphabet);if(null==t){const n=me.q7.map(e=>new Wi.a(e.name,e.alphabet,.9));t=(0,Fe.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(me.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(me.gp.separator)??void 0;if(this.notation===me.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(me.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(me.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===me.YI.RNA||this.alphabet===me.YI.DNA?De.o.NUCLEOTIDE:De.o.AA}get helmCompatible(){return this.column.getTag(me.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==me.Hi.HELM||this.alphabet==me.YI.UN){const e=this.column.getTag(me.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case me.YI.PT:return 20;case me.YI.DNA:case me.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===me.Hi.HELM||this.alphabet===me.YI.UN&&"true"===this.column.getTag(me.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ve.b9[me.Hi.FASTA]?ve._S:i??ve._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ve._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ve.b9[me.Hi.FASTA]?ve._S:o??ve._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new $e.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===me.Hi.HELM?n:this.notation===me.Hi.CUSTOM||this.notation===me.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(me.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===me.YI.DNA||e===me.YI.RNA||e===me.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(me.gp.positionNames);this._posList=e?e.split(me.z1).map(e=>e.trim()):R().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===me.Hi.FASTA}isSeparator(){return this.notation===me.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===me.Hi.HELM}isCustom(){return this.notation===me.Hi.CUSTOM}isBiln(){return this.notation===me.Hi.BILN}isRna(){return this.alphabet===me.YI.RNA}isDna(){return this.alphabet===me.YI.DNA}isPeptide(){return this.alphabet===me.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(me.Hi.FASTA))return me.Hi.FASTA;if(this.units.toLowerCase().startsWith(me.Hi.SEPARATOR))return me.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(me.Hi.HELM))return me.Hi.HELM;if(this.units.toLowerCase().startsWith(me.Hi.CUSTOM))return me.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(me.Hi.BILN))return me.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===me.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${me.Hi.SEPARATOR}' requires separator value.`);l.setTag(me.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===me.Hi.HELM?"helm":"sequence");const c=o.getTag(me.gp.aligned);c&&l.setTag(me.gp.aligned,c);let h=o.getTag(me.gp.alphabet);h||this.notation!==me.Hi.HELM||e===me.Hi.HELM||(h=me.YI.UN),null!=h&&l.setTag(me.gp.alphabet,h);let u=o.getTag(me.gp.alphabetSize);null!=h&&u&&l.setTag(me.gp.alphabetSize,u);const d=o.getTag(me.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(me.gp.alphabetIsMultichar,d),e==me.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(me.gp.alphabetSize,u)),e===me.Hi.BILN&&(l.setTag(me.gp.separator,"-"),l.meta.units=me.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[me.Hi.FASTA,me.Hi.SEPARATOR,me.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!ji.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(me.Hi.FASTA))return null===this.column.getTag(me.gp.alphabet)||this.getAlphabetIsMultichar()?me.J9:Fe.tm;if(this.units.toLowerCase().startsWith(me.Hi.SEPARATOR))return(0,me.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(me.Hi.HELM))return me.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return pe.Z.HAMMING;switch(this.alphabet){case me.YI.DNA:case me.YI.RNA:case me.YI.PT:}return pe.Z.LEVENSHTEIN}getDistanceFunction(){return pe.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(me.gp.isHelmCompatible))return"true"===this.column.getTag(me.gp.isHelmCompatible);const e=(await(0,we.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,me.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(me.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(me.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===me.Hi.FASTA}toSeparator(e){return e===me.Hi.SEPARATOR}toHelm(e){return e===me.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ve.b9[me.Hi.FASTA]:ve.b9[me.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,me.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(fe.EK,"$1")),n===ve.b9[me.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ve.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new Fe.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(me.z1)},h=this.column.getTag(me.gp.positionNames);h&&i.setTag(me.gp.positionNames,c(h));const u=this.column.getTag(me.gp.positionLabels);return u&&i.setTag(me.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case me.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case me.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Ui(e,n,o.isHelm())};break;case me.Hi.HELM:{const e=o.alphabet===me.YI.DNA||o.alphabet===me.YI.RNA,t=o.getHelmWrappers();i=function(n){return qi(n,t,e)};break}case me.Hi.BILN:i=function(e){return zi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===me.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${me.Hi.SEPARATOR}'.`);const n=this;if(e===me.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===me.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===me.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===me.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[$e.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[$e.j.seqHandler]=new ji(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(fe.EK,"$1")),o===ve._S?r=ve.b9[me.Hi.FASTA]:o===fe.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Ui(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==me.Hi.HELM)return e;const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return qi(this.splitter(e),t,n)}convertToBiln(e){return this.notation==me.Hi.BILN?e:zi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(fe.EK,"$1"),r=r===fe.q7?null:r),n[e]=r||null}return new Fe.Mu(n.filter(e=>!!e),ve.b9[me.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Ui(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(fe.EK,"$1")),o===ve._S?r=ve.b9[me.Hi.SEPARATOR]:o===fe.q7&&(r=""),i[t]=r}return i.join(t)}function qi(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,h=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ve._S?r=ve.b9[me.Hi.HELM]:(n&&(r=r.replace(fe.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),h[t-o]=r}l.push(`${i}${t+1}{${h.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ve._S?s=ve.b9[me.Hi.HELM]:(n&&(s=s.replace(fe.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function zi(e){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const t=e.graphInfo.disjointSeqStarts,n=new Array(e.length);for(let t=0;t<e.length;++t)n[t]=e.getCanonical(t),n[t]?.includes("-")&&(n[t]=`[${n[t]}]`);for(let i=0;i<e.graphInfo.connections.length;i++){const o=e.graphInfo.connections[i],r=`${i+1}`,s=o.seqIndex1,a=o.seqIndex2,l=t[s]+o.monomerIndex1,c=t[a]+o.monomerIndex2,h=`${n[l]}(${r},${o.rGroup1})`,u=`${n[c]}(${r},${o.rGroup2})`;n[l]=h,n[c]=u}return t.map((i,o)=>{const r=o+1<t.length?t[o+1]:e.length;return n.slice(i,r).join("-")}).join(".")}{const t=new Array(e.length);for(let n=0;n<e.length;++n)t[n]=e.getCanonical(n),t[n]?.includes("-")&&(t[n]=`[${t[n]}]`);return t.join("-")}}class Yi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return ji.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,kt.b2)();return new Vi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Ai.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Ai.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Ai.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Ai.vF(e,o.monomers)}catch(e){const[t,n]=(0,Se.AP)(e);return Dr.logger.error(t,void 0,n),Ai.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),s=e.dataFrame,l=(0,xi.qj)(s,e.name),c=await this.getHelmToMolfileConverter(o),h=e.toList(),u=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n])}if(t&&p){const t=await p.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==me.Hi.FASTA)throw new Error(`The column of notation '${me.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=me.Hi.FASTA,ji.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${me.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${me.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=me.Hi.SEPARATOR,e.column.setTag(me.gp.separator,t),ji.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${me.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=me.Hi.HELM,ji.setTags(e)}}async function Ki(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![me.Hi.FASTA,me.Hi.SEPARATOR,me.Hi.HELM,me.Hi.BILN].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await Wr.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[$e.j.notationProvider]&&(i.temp[$e.j.notationProvider]=e.cell.column.temp[$e.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),s=(r.graphInfo?.connections?.length??0)>0,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Wr.toAtomicLevel(o,i,s||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){Dr.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Zi="#333333",Xi="rgba(60, 177, 115, 0.1)",Ji="rgba(240, 240, 240, 0.5)",Qi="rgba(100, 100, 100, 0.3)";class eo{constructor(e=io.DEFAULT_TRACK_HEIGHT,t=io.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class to extends eo{constructor(e=new Map,t=io.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,io.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=De.o.NUCLEOTIDE;break;default:t=De.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,pi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(s.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(s.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(s.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=t+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,e,t,n,i,o,r,s,a,h,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,h){const u=r+e-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=t+e*s,m=s-2;r+e===l&&(this.ctx.fillStyle=Xi,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=Ji,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,u),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class no extends eo{constructor(e,t=io.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,io.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,t,i),l===a&&(this.ctx.fillStyle=Xi,this.ctx.fillRect(c,t,h,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=Ji,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Zi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const io={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},oo={BASE:io.DOTTED_CELL_HEIGHT+io.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+io.TITLE_HEIGHT+io.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+io.DEFAULT_TRACK_HEIGHT+io.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+io.DEFAULT_TRACK_HEIGHT+io.TRACK_GAP}};class ro{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||oo.BASE,sliderHeight:e.sliderHeight||io.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(io.DEFAULT_TRACK_HEIGHT)}),!(e<oo.WITH_TITLE()||e<oo.WITH_WEBLOGO()))if(e<oo.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-oo.WITH_WEBLOGO();t.setHeight(io.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>oo.WITH_BOTH()){const n=e-oo.WITH_BOTH();t.setHeight(io.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<oo.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<oo.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=oo.WITH_TITLE()?(io.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=oo.WITH_WEBLOGO();else{if("conservation"!==e)return;t=oo.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?oo.WITH_BOTH():oo.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=oo.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,io.TITLE_HEIGHT),this.ctx.fillStyle=Zi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+io.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof to&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0,l=this.config.headerHeight-io.SLIDER_HEIGHT-io.DOTTED_CELL_HEIGHT,c=l-io.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){h=e,u=n-i;break}g=i-io.TRACK_GAP}let f=null;if(h){const e=this.tracks.get(h);e&&(f=e.getMonomerAt(t,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=f,h)){const e=this.tracks.get(h);e instanceof to&&(e.setHovered(r,f),window.requestAnimationFrame(()=>this.redraw()))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=f,h)){const t=this.tracks.get(h);if(t){const n=t.getTooltipContent(r,f);if(n)return void s.tooltip.show(n,e.clientX+16,e.clientY+16)}}h&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=oo.WITH_TITLE();l&&io.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-io.SLIDER_HEIGHT,h=c-io.DOTTED_CELL_HEIGHT,u=h-io.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const g=this.getTrack("conservation");g&&g.isVisible()&&p.push({id:"conservation",track:g});let f=u;for(const{track:e}of p){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-io.TRACK_GAP}if(this.drawDottedCells(0,h,n,io.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:io.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=t+io.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=e+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,t),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Zi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,io.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,io.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,io.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-io.SLIDER_HEIGHT;return t>n&&t<n+io.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-io.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+io.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0,a=this.config.headerHeight-io.SLIDER_HEIGHT-io.DOTTED_CELL_HEIGHT,l=a-io.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of u){const i=m-t.getHeight();if(n>=i&&n<m){c=e,h=n-i;break}m=i-io.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=oo.WITH_TITLE()&&t&&(so(e.left??0,n,i)||so(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-io.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:oo.BASE,WITH_TITLE:oo.WITH_TITLE(),WITH_WEBLOGO:oo.WITH_WEBLOGO(),WITH_BOTH:oo.WITH_BOTH()}}}function so(e,t,n){return e>=t&&e<=n}class ao{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){ao.conservationCache=new a.LruCache(100),ao.webLogoCache=new a.LruCache(100),ao.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return ao.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return ao.conservationCache.getOrCreate(i,()=>{const o=ao.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return ao.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/ao.CHUNK_SIZE)*ao.CHUNK_SIZE,s=Math.ceil(n/ao.CHUNK_SIZE)*ao.CHUNK_SIZE;for(let t=r;t<s;t+=ao.CHUNK_SIZE){const n=Math.min(t+ao.CHUNK_SIZE,i),r=ao.getChunkCacheKey(e.column,t,n),s=ao.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/ao.CHUNK_SIZE)*ao.CHUNK_SIZE,s=Math.ceil(n/ao.CHUNK_SIZE)*ao.CHUNK_SIZE;for(let t=r;t<s;t+=ao.CHUNK_SIZE){const n=Math.min(t+ao.CHUNK_SIZE,i),r=ao.getChunkCacheKey(e.column,t,n),s=ao.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class lo extends to{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=ao.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=ao.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class co extends no{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=ao.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=ao.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class ho{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}constructor(e,t,n){this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=Fe.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ve.Hi.HELM})(n)}createCellRendererBack(e,t){const n=Dr.properties.maxMonomerLength||4,i=new uo(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class uo extends He.Jy{constructor(e,t,n,i){super(e,t,Dr.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=He.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:Fe.zS}})}}async function po(){return await Wr.getMonomerLibHelper()}async function mo(){await Wr.initBio()}function go(e){return Wr.sequenceTooltip(e)}async function fo(e){return await Wr.standardiseMonomerLibrary(e)}async function yo(e,t,n){await Wr.matchWithMonomerLibrary(e,t,n)}function bo(){return Wr.getBioLib()}function vo(e){return Wr.getSeqHandler(e)}function wo(e){return Wr.getRegionPanel(e)}async function Co(e){return await Wr.libraryPanel(e)}function So(e){Wr.GetRegionEditor(e)}function Ao(e){Wr.SplitToMonomersEditor(e)}function xo(e){Wr.SequenceSpaceEditor(e)}function Eo(e){Wr.SeqActivityCliffsEditor(e)}function Mo(){return Wr.customSequenceCellRenderer()}function To(){return Wr.fastaSequenceCellRenderer()}function _o(){return Wr.separatorSequenceCellRenderer()}function Io(){return Wr.bilnSequenceCellRenderer()}function Lo(e,t,n){return Wr.refineNotationProviderForBiln(e,t,n)}function No(e){return Wr.macroMolColumnPropertyPanel(e)}function Po(e){return Wr.compositionAnalysisWidget(e)}function Ro(){return Wr.macromoleculeDifferenceCellRenderer()}function $o(e,t,n,i,o){return Wr.sequenceAlignment(e,t,n,i,o)}function Oo(){return Wr.webLogoViewer()}function ko(){return Wr.vdRegionsViewer()}function Ho(e,t,n,i){return Wr.getRegion(e,t,n,i)}async function Fo(e,t,n,i,o){await Wr.getRegionTopMenu(e,t,n,i,o)}async function Go(e,t,n,i,o,r,s,a,l){return await Wr.activityCliffs(e,t,n,i,o,r,s,a,l)}async function Bo(e,t,n,i,o){return await Wr.macromoleculePreprocessingFunction(e,t,n,i,o)}async function Do(e,t){return await Wr.helmPreprocessingFunction(e,t)}async function Vo(e,t,n,i,o,r,s,a,l){return await Wr.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function Wo(e,t,n,i){await Wr.toAtomicLevel(e,t,n,i)}async function jo(e){await Wr.toAtomicLevelAction(e)}async function Uo(e){return await Wr.toAtomicLevelPanel(e)}async function qo(e){return await Wr.sequence3dStructureWidget(e)}function zo(){Wr.multipleSequenceAlignmentDialog()}async function Yo(e,t,n){return await Wr.alignSequences(e,t,n)}async function Ko(){return await Wr.compositionAnalysis()}function Zo(e){return Wr.importFasta(e)}function Xo(e){return Wr.importBam(e)}function Jo(){Wr.convertDialog()}function Qo(e){Wr.convertColumnAction(e)}function er(){return Wr.monomerCellRenderer()}async function tr(e){return await Wr.testDetectMacromolecule(e)}async function nr(e,t){return await Wr.splitToMonomersTopMenu(e,t)}function ir(e){return Wr.getHelmMonomers(e)}function or(){return Wr.similaritySearchViewer()}function rr(){return Wr.similaritySearchTopMenu()}function sr(){return Wr.diversitySearchViewer()}function ar(){return Wr.diversitySearchTopMenu()}function lr(e){Wr.searchSubsequenceEditor(e)}function cr(e){Wr.SubsequenceSearchTopMenu(e)}async function hr(e,t,n){return await Wr.sequenceIdentityScoring(e,t,n)}async function ur(e,t,n){return await Wr.sequenceSimilarityScoring(e,t,n)}async function dr(){await Wr.manageMonomerLibraries()}async function pr(){await Wr.manageLibrariesView()}async function mr(){await Wr.manageMonomersView()}async function gr(){return await Wr.manageMonomerLibrariesView()}async function fr(e){await Wr.manageMonomerLibrariesViewTreeBrowser(e)}function yr(){Wr.saveAsFasta()}function br(){return Wr.bioSubstructureFilter()}function vr(){return Wr.bioSubstructureFilterTest()}async function wr(){await Wr.webLogoLargeApp()}async function Cr(){await Wr.webLogoAggApp()}async function Sr(){await Wr.getRegionApp()}async function Ar(){await Wr.getRegionHelmApp()}function xr(){Wr.longSeqTableSeparator()}function Er(){Wr.longSeqTableFasta()}function Mr(){Wr.longSeqTableHelm()}function Tr(e,t){Wr.addCopyMenu(e,t)}async function _r(){await Wr.demoBioSimilarityDiversity()}async function Ir(){await Wr.demoBioSequenceSpace()}async function Lr(){await Wr.demoBioActivityCliffs()}async function Nr(){await Wr.demoBioAtomicLevel()}async function Pr(e){await Wr.sdfToJsonLib(e)}async function Rr(e,t){return await Wr.seq2atomic(e,t)}async function $r(e,t){return await Wr.seqIdentity(e,t)}async function Or(e,t,n){await Wr.detectMacromoleculeProbe(e,t,n)}async function kr(){return await Wr.getSeqHelper()}async function Hr(e,t,n){return await Wr.getMolFromHelm(e,t,n)}var Fr=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},Gr=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Br=function(e,t){return function(n,i){t(n,i,e)}};const Dr=new di;let Vr=null;r.decorators||(r.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{r.decorators[e]||(r.decorators[e]=function(e){return function(e,t,n){}})});class Wr{static async getMonomerLibHelper(){return await Hn.getInstance()}static async initBio(){null==Vr&&(Vr=async function(){const e="Bio: _package.initBio()";Dr.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Re.j)(),i=await Dr.getProperties(),o=new ui(i);Dr.properties=o;const s=await Hn.getInstance(),l=await(0,Pe.ub)();l.explicit&&(l.explicit=[],await(0,Pe.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();Dr.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new Yi(s,n);Dr.completeInit(p,c,u,n),Dr.logger.debug(`${e}, end`),function(){const e=e=>{setTimeout(()=>{if(e.isDetached)return;const t=e.dataFrame;if(!t)return;const n=t.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=Dr.seqHelper.getSeqHandler(i)}catch(e){continue}if(!n)continue;if(n.isHelm()||n.alphabet===me.YI.UN)continue;const o=e.col(i.name);if(!o)continue;let s=!!e.tableView&&Array.from(e.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);if(n.isMsa()){const l=(e,t)=>Number.isNaN(e)?t:e,c=()=>l(Math.max(Number.parseInt(i.getTag(me.gp.positionShift)??"0"),0),0)+1,u=()=>l(Number.parseInt(i.getTag(me.gp.selectedPosition)??"-2"),-2),d=()=>He.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const g=i.categories;for(let e=0;e<g.length;e++){const t=g[e];t&&t.length>m&&(m=t.length,p=e)}const f=g[p],y=n.splitter(f),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=i.length>1e5||b<50?v.WITH_TITLE:i.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,S=null;const A=a.debounce(h.merge(t.onFilterChanged,t.onDataChanged.pipe((0,k.filter)(e=>e?.args?.column===i))),100).subscribe(()=>{ao.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),S&&(S.resetViewportTracking(),S.forceUpdate()),setTimeout(()=>{e.isDetached||e.invalidate()},50)});e.sub(A);const x=r=>{const l=[],h=new co(n,b,45,"default","Conservation");S=h,l.push({id:"conservation",track:h,priority:1});const p=new lo(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new ro({canvas:e.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(t,n)=>{setTimeout(()=>{const o=c(),r=u();if(o!==n.start&&i.setTag(me.gp.positionShift,(n.start-1).toString()),r!==t&&(i.setTag(me.gp.selectedPosition,t.toString()),t>=0&&!s&&e.tableView&&R()(e.dataFrame?.columns.numerical).find(e=>!0))){s=!0;const t=e.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});e.tableView.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:t=>{e.isDetached||t<v.WITH_TITLE||setTimeout(()=>e.props.colHeaderHeight=t)}},o);m.setupTooltipHandling(),l.forEach(({id:e,track:t})=>{m.addTrack(e,t)}),m.setSelectionData(t,i,n),b>50&&(e.props.colHeaderHeight=w,setTimeout(()=>{e.isDetached||(o.width=400)},300)),e.sub(e.onCellRender.subscribe(e=>{const t=e.cell;if(!t||!t.isColHeader||t?.gridColumn?.name!==o?.name)return;const n=e.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,u(),s,e,i.name)}))};(0,we.pj)().then(e=>{const t=e.getMonomerLib();x(t)}).catch(e=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}}},1e3)},t=(r.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)}),r.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Vr}static sequenceTooltip(e){const t=new fi(e,Dr.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();r.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await en(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const o=a.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!o)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const r=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),s=(await en(r)).map((e,t)=>({sym:e.symbol,smiles:un(e.smiles??"",e.rgroups??[]),original:e.smiles,source:r[t]?.lib?.source})).filter(e=>!!e?.smiles&&!e.smiles.includes("[*:")),l=a.Column.fromList(a.COLUMN_TYPE.STRING,"MonomerSmiles",s.map(e=>e.smiles));l.semType=a.SEMTYPE.MOLECULE;const c=await o.apply({molecule:l,targetNotation:a.chem.Notation.Smiles});if(!c||c.length!==l.length)throw new Error("Error canonicalizing monomer smiles");c.toList().forEach((e,t)=>s[t].smiles=e);const h=e.col(t),u=await o.apply({molecule:h,targetNotation:a.chem.Notation.Smiles});if(!u||u.length!==h.length)throw new Error("Error canonicalizing molecules");const d=u.toList(),p=e.clone(),m=p.columns.addNewString(p.columns.getUnusedName("Matched monomer smiles"));m.semType=a.SEMTYPE.MOLECULE;const g=p.columns.addNewString(p.columns.getUnusedName("Matched monomer symbol"));g.semType="Monomer";const f=p.columns.addNewString(p.columns.getUnusedName("Matched monomer source"));p.columns.setOrder([t,g.name,m.name,f.name]);for(let e=0;e<d.length;e++){const t=d[e];if(t)for(let n=0;n<s.length;n++)if(s[n].smiles===t){m.set(e,s[n].original,!1),g.set(e,s[n].sym,!1),f.set(e,s[n].source??"",!1);break}}return p}(e,t.name,Dr.monomerLib,n);r.shell.addTableView(i)}static getBioLib(){return Dr.monomerLib}static getSeqHandler(e){return Dr.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:Dr.name,name:t});if(1!==n.length)throw new Error(`Package '${Dr.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new wi(i,Dr.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=s.label("Manage monomer libraries");return Gn()(e).addClass("d4-link-action"),e.onclick=async()=>await Un(),new a.Widget(e)}()}static GetRegionEditor(e){try{new wi(e,Dr.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(`Get region editor error: ${t}`),Dr.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ri;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new xe({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new Ye}static fastaSequenceCellRenderer(){return new Ye}static separatorSequenceCellRenderer(){return new Ye}static bilnSequenceCellRenderer(){return new Ye}static refineNotationProviderForBiln(e,t,n){return"-"===n&&(!(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))&&!Object.keys(t.freq).some(e=>e.includes("[")||e.includes("]")))&&(e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=me.Hi.BILN,e.temp[$e.j.notationProvider]=new ho(n,Dr.seqHelper,e),!0))}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===a.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=Dr.properties?Dr.properties.maxMonomerLength:4;if(ke.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(ke.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=Dr.properties?Dr.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==me.Hi.HELM&&(d=s.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,h,c,u];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[me.gp.alphabet],r=o===me.YI.DNA||o===me.YI.RNA?De.o.NUCLEOTIDE:De.o.AA,l={},c=n.getSeqHandler(e.cell.column),h=e.cell.rowIndex,u=c.getSplitted(h),d={};R().count(0).take(u.length).filter(e=>!u.isGap(e)).forEach(e=>{let t=u.getCanonical(e);r===De.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&u.graphInfo?.polymerTypes){const n=u.graphInfo.polymerTypes[e];d[t]=(0,Fe.MD)(n)}});const p=(0,pi.F)(l,r,t,Object.keys(d).length?d:void 0);return Array.from(p.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(p),new a.Widget(i)}(e,Dr.monomerLib,Dr.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ze}static sequenceAlignment(e,t,n,i,o){const r=new dt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new ot.oP}static vdRegionsViewer(){return new ct}static getRegion(e,t,n,i){return yi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const s=yi(t,n??null,i??null,o??null);t.dataFrame.columns.add(s),await r.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,h,u,d,p){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ti.V)(t,"Activity Cliffs"))return;const m=_e(e),g={units:t.meta.units,aligned:t.getTag(me.gp.aligned),separator:t.getTag(me.gp.separator),alphabet:t.getTag(me.gp.alphabet)},f=h,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,f,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,g,u,gt,ft,wt,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),S=await new Promise((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,Se.AP)(e);throw Dr.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return S?.props?.xColumnName&&S?.props?.yColumnName&&e.col(S.props.xColumnName)&&e.col(S.props.yColumnName)&&(e.col(S.props.xColumnName).set(0,e.col(S.props.xColumnName).get(0)),e.col(S.props.yColumnName).set(0,e.col(S.props.yColumnName).get(0))),S}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:s}=await pt(e,t,o,n,i);return{entries:r,options:s}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,mt.BQ)(e,Dr.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=j.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,s,c,h,u){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);const d=r.shell.tv.dataFrame==e?r.shell.tv:void 0;return(0,ti.V)(t,"Sequence Space")?(s||(s=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await Le(e,[t],n,[i],[1],[s],"MANHATTAN",o,h??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Vr;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??Dr.monomerLib,r=Dr.seqHelper,s=Dr.rdKitModule;await(0,Ci.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Ki(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(s.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(t.mol,e,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){Dr.logger.error(e)}return a.Widget.fromRoot(s.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Ki(e);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=Ei.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=s.div([t],{style:{aspectRatio:"1"}})}catch(e){n=s.divText("Couldn't get 3D structure")}}catch(e){n=s.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,ii.D)({},Dr.seqHelper).catch(e=>{const[t,n]=(0,Se.AP)(e);if(e instanceof ni.Ap)return r.shell.warning(e.element),void Dr.logger.warning(t);r.shell.error(t),Dr.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,ii.D)({col:e,clustersCol:t,...n},Dr.seqHelper)}static async compositionAnalysis(){const e=r.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(Dr.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,ti.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>Dr.seqHelper.getSeqHandler(e).isMsa()),o=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}static importFasta(e){return new ge.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Oe.me)()[0];(0,Tt.C)(e,Dr.seqHelper)}static convertColumnAction(e){(0,Tt.C)(e,Dr.seqHelper)}static monomerCellRenderer(){return new ci}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const o=[];for(const s of n)try{const t=await r.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${e}`,s}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,et.cb)(10),!(0,ti.V)(t,"Sequence space"))return e;const n=ye(t,Dr.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ue.uF.MONOMER,e.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const o=/(\d+)(?: \((\d+)\))?/,s=e=>{o.lastIndex=0;const t=e.match(o);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ue.uF.MONOMER,o.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const r=100;let a=0;for(;i.columns.byName(o.name)&&a<r;)o.name=s(o.name),a++;i.columns.add(o)}await r.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return Dr.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new xt(Dr.seqHelper)}static similaritySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Et(Dr.seqHelper)}static diversitySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Oe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new mt.a7(t,Dr.seqHelper)}static SubsequenceSearchTopMenu(e){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),r.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=Dr.seqHelper;return Si(e,t,n,be.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=Dr.seqHelper;return Si(e,t,n,be.SIMILARITY,i)}static async manageMonomerLibraries(){Un()}static async manageLibrariesView(){await qn()}static async manageMonomersView(){const e=await nn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await qn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await Hn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await nn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,_t.TE)()}static bioSubstructureFilter(){return new It._i(Dr.seqHelper,Dr.logger)}static bioSubstructureFilterTest(){return new It._i(Dr.seqHelper,Dr.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new oi(e,"webLogoLargeApp"),n=await Dr.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new oi(e,"webLogoAggApp"),n=await Dr.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new vi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await Dr.files.readCsv("samples/HELM_empty_vals.csv"),n=new vi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,Ne.dW)());r.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(Dr.seqHelper,me.Hi.FASTA)]);r.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(Dr.seqHelper,me.Hi.HELM)]);r.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(me.Hi).filter(e=>e!==me.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,o=e.rowIndex,s=n.getSeqHandler(i),a=t===me.Hi.SEPARATOR?Dr.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${t}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,Dr.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await Dr.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=r.shell.addTableView(e);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Oe.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await r.functions.eval("Bio:SeqSpaceDemo"),t=await r.dapi.projects.find(e.id);await t.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await Dr.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=r.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Wr.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,pe.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),Gn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===a.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(t),Dr.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await Dr.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const t=r.shell.addTableView(e),n=e.col("HELM");await Wr.toAtomicLevel(e,n,!0,!1),(0,Oe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Oe.Kd)(t.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(fe.Ec).forEach(t=>{if("symbol"===t){const o=e.get(fe.Ec[t],n);i[t]="."===o?e.get(fe.yw,n):o}else if("rgroups"===t){const o=e.get(fe.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else fe.Ec[t]&&(i[t]=e.get(fe.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await Wr.getMonomerLibHelper()).getMonomerLib(),l=Dr.seqHelper,c=await(0,Re.j)(),h=(await(0,Ci.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(e){const[t,n]=(0,Se.AP)(e);throw Dr.logger.error(t,void 0,n),e}}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await Si(i,n,t,be.IDENTITY,Dr.seqHelper)).get(0)}catch(e){const[t,n]=(0,Se.AP)(e);throw Dr.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(e),u=t?h.getCol(t):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,et.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Wr.initBio(),Dr.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=Dr.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,Dr.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,t,n,Dr.monomerLib)}}Fr([r.decorators.func({description:"Returns an instance of the monomer library helper",outputs:[{type:"object",name:"result"}]}),Gr("design:type",Function),Gr("design:paramtypes",[]),Gr("design:returntype",Promise)],Wr,"getMonomerLibHelper",null),Fr([r.decorators.init({}),Gr("design:type",Function),Gr("design:paramtypes",[]),Gr("design:returntype",Promise)],Wr,"initBio",null),Fr([r.decorators.func({tags:["tooltip"]}),Br(0,r.decorators.param({options:{semType:"Macromolecule"}})),Gr("design:type",Function),Gr("design:paramtypes",[a.Column]),Gr("design:returntype",a.Widget)],Wr,"sequenceTooltip",null),Fr([r.decorators.func({}),Gr("design:type",Function),Gr("design:paramtypes",[String]),Gr("design:returntype",Promise)],Wr,"standardiseMonomerLibrary",null),Fr([r.decorators.func({"top-menu":"Bio | Manage | Match with Monomer Library...",description:"Matches molecules in a column with monomers from the selected 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this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new x),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const p=Object.entries(this._freqs).sort((e,t)=>e[0]!==g._S&&t[0]!==g._S?t[1].value-e[1].value:e[0]===g._S&&t[0]===g._S?0:e[0]===g._S?-1:1);for(const[n,i]of p){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){let c=a;const u=l.bounds,d=u.left;let m=y.S$;if(r)try{m=r.getMonomerTextColor(o,a);const e=r.getMonomer((0,A.Y)(o),a);e&&e.symbol!==a&&(c=e.symbol)}catch(e){p(e)}const f=(0,h.zS)(c,s);e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=m,e.textAlign="left",e.font=t;const g=e.measureText(f);e.setTransform(u.width/g.width,0,0,u.height/i,d,u.top),e.fillText(f,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,S.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const T=d.Fo;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const _=new class{render=20};class I extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,T.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,T.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,T.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,T.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,T.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,T.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,T.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,T.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,T.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,T.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,T.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,T.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,T.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,T.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,T.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,T.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,T.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,T.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,T.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,T.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,T.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(E.Render,"monomerLib changed")}))}),this.viewSyncer=new f.g(b._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return null==r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(g._S)||e.getFreq(g._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start 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i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function fe(e,t,n,i,o){for(var r,s,a,l,c,u,h,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(u=c.target,m=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),m=!0,h=o(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!m&&(h=o(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function ge(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Se={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,u,a);e._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,u.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Me(e,t,n,i,o,r,s,l,u){if(!i&&"undirected"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new W("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(r=""+r,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&r===s)throw new W("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(r),f=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(u?!h:!l)return g;if(u){var y=p.attributes;p.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new W("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Ae(e,r,{}),v=!0,r===s&&(f=m,w=!0)),f||(f=Ae(e,s,{}),w=!0),d=new z(i,o,m,f,l),e._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Te(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Ee=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Se,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?j:"directed"===e.type?U:q;h(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),h(s(t),"_options",e),Ce.forEach(function(e){return h(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new W('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Te(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Te(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Te(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Te(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Te(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Te(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new D("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){ge(r=o[t]);var u=r,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new D("Graph.import: invalid edges. 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requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const p=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=r.p(`Kalign version: ${h.b9}`,"kalign-version"),g=r.input.float("Gap open",{value:e.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),v=r.inputs([g,y,m]),w=r.button("Alignment parameters",()=>{v.hidden=!v.hidden,[g,y,m].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),v.hidden=!0,w.prepend(r.icons.settings(()=>null));const C=[p.root.style],S=[m.root.style,f.style];let A,x=d;const M=r.input.column("Sequence",{table:u,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(M.value=x);x=e,L.disabled=!1,A=await I(M.value,u,t,C,S,p,T,g,y,m,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});M.setTooltip("Sequences column to use for alignment");const T=r.input.column("Clusters",{table:u,value:e.clustersCol});T.nullable=!0;const E=r.dialog("MSA").add(M).add(T).add(p).add(v).add(w).add(b).add(f).onOK(async()=>{await _(M,u,A,n,a)}),L=E.getButton("OK");if(M.fireChanged(),e.col)return A=await I(e.col,u,t,C,S,p,T,g,y,m,b),void await _(M,u,A,n,a);E.show()})}async function _(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(null==n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");t.columns.add(a),await i.data.detectSemanticTypes(t),r(a)}catch(e){s(e)}finally{l.close()}}async function I(e,t,n,r,s,d,p,m,f,g,y){try{if(e.semType!==o.SEMTYPE.MACROMOLECULE)return;const i=t.columns.getUnusedName(`msa(${e.name})`);if((0,u.l)(e,e.name,n,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT])[0]){L(r,s,"kalign"),m.value=null,f.value=null,g.value=null;const o=n.getSeqHandler(e),c=o.isFasta()?e:o.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(t,c,!1,i,p.value,void 0,void 0,void 0,y.value)}if((0,u.l)(e,e.name,n,[a.Hi.HELM],[])[0])return L(r,s,"pepsea"),m.value??=h.HX.pepsea.gapOpen,f.value??=h.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,e,i,d.value,m.value,f.value,p.value,void 0,y.value);if((0,u.l)(e,e.name,n,[a.Hi.SEPARATOR],[a.YI.UN])[0]){const o=n.getSeqHandler(e).convert(a.Hi.HELM);return L(r,s,"pepsea"),m.value??=h.HX.pepsea.gapOpen,f.value??=h.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,o,i,d.value,m.value,f.value,p.value,void 0,y.value)}return m.value=null,f.value=null,g.value=null,void L(r,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),T._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(2447);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}}).onCancel(()=>{f()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new M:this.notation===c.Hi.SEPARATOR?new T(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class M extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class T extends p.O{emptyProps=new A("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new 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T&&(e=T.info),e?_(e.description,_(e.vendor,"No GPU description available")):"No GPU description available"})}().then(e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)})}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";var P=n(1991),R=n.n(P);a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class ${constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class O{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach(n=>{null!=e[n].value&&(t[n]=e[n].value)}),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new I,[c.c.T_SNE]:new L},this.dbScanParams=new $,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach(e=>{const t=e.options.get(l.n3)??"",n=e.friendlyName??e.name,i=e.options.get(l.C0)??"",o=e.options.get(l._X)??"",r=e.options.get(l.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!o.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:o?o.split(","):[],distanceFunctions:r?r.split(","):[]})}),this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,items:r.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings(()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)},"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings(()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)},"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let o=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,o=!0),o||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=s.icons.settings(async()=>{u?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u},"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find(e=>!!this.columnFunctionsMap[e.name])??null,t=s.input.column("Column",{table:this.tableInput.value,value:e,nullable:!1,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach(e=>this.colInputRoot.append(e)),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;if(!e)return;const t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach(e=>{Object.keys(this.supportedFunctions).forEach(t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))})}),this.regenerateColInput()};t(),R()(e.columns).some(e=>!!e.getTag(a.Tags.SemanticDetectionDuration))||e.meta.detectSemanticTypes().then(()=>{t()})}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach(e=>this.similarityMetricInputRoot.append(e)),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach(n=>{const i=t[n],o="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,s.tooltip.bind(o.input??o.root,i.disableTooltip??"")):s.tooltip.bind(o.input??o.root,i.tooltip)}),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find(e=>e.property.name===r.name);s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe(e=>{this.preprocessingFunctionSettings[r.name]=e}),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}}var k=n(9713),H=n(6295);const B=e=>null==e;function F(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class G{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),g=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(h.set(r,i),s<m&&(m=s),a>f&&(f=a),e())}})}await Promise.all(l),n&&h.forEach((e,t)=>{h[t]=(e-m)/(f-m)}),i(h)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),u=new Float32Array(s),h=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)r[e]<m&&(l[p]=h[e],c[p]=d[e],u[p]=r[e],p++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),r.forEach((e,t)=>r[t].threshold=o);const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,u)=>{const h=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:p,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const p=await Promise.all(h),m=p.reduce((e,t)=>e+t.i.length,0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),u=new Array(this._workerCount),h=e[0].length,d=e.map(e=>e[t]),p=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise((n,i)=>{const u=t*p,m=t===this._workerCount-1?h:(t+1)*p;m<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(u,m)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const m=await Promise.all(u),f={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)F(f.knnDistances,f.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return f}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)F(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise((c,h)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:u,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}});const d=await Promise.all(h),p=d.reduce((e,t)=>e+t.distance.length,0),m=new Float32Array(p);let f=0;for(const e of d)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=B(e[l])||B(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,W,j=n(8774);(W=V||(V={})).none="none",W.bold="bold",W.dashed="dashed";class U{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new j.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,u,h,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const S=this.sp.pointToScreen(this.lines.to[e]);let A=null==S?void 0:S.x,x=null==S?void 0:S.y;const M=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&A&&x&&Math.hypot(A-w,x-C)/M>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let S=null;if(b){t=this.getLineLength(w,C,A,x);const o=this.getPointOnDistance(w,C,A,x,i,t),r=this.getPointOnDistance(A,x,w,C,n,t);w=o.x,C=o.y,A=r.x,x=r.y,S=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,A,x,e):this.findControlPoint(b,A,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(S.x,S.y,A,x)}else(!this.lines.skipShortLines||Math.pow(A-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(A,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,A,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,A,x,i,t),n=b?S.x:w,o=b?S.y:C;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:w,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const p=new j.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!d||d>g)&&(d=g),h[r]=Math.max(m,f),c[r]=a,u[r]=p}for(let e=0;e<c.length;e++)h[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const s=n-o*((n-e)/r),l=i-o*((i-t)/r);return new a.Point(s,l)}findControlPoint(e,t,n,i,o,r){const s=t+(i-t)/2,l=n+(o-n)/2;let c=s-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*u,l-d/2*c):new a.Point(s-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const q="dimensionality-reducer-terminate-event";var z,Y,K=n(3629);async function Z(e,t,i,o,s,a,l){let c=await async function(e,t,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q).subscribe(()=>{try{h?.terminate()}finally{d.unsubscribe()}});h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{B(n)||B(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout(()=>h.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,o,s,a,l);return c=c.map(e=>(0,K.S8)(e)),c}(Y=z||(z={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const X={[z.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[z.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return M(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!T&&(T=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==T))return null;let e=!1;if(E&&(E.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!E||e){const e=1e9,t=T.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return E=yield T.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),E}catch(e){return console.error("Failed to create device with required limits",e),E=yield T.requestDevice(),E}}return E})}();if(!s)return null;const a=Object.values(J);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(z).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map((e,t)=>function(e,t=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!ne[s]||!ne[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce((e,t)=>Math.max(e,t),0),h=te[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*u);a.forEach((e,t)=>{p.set(e,t*u)});let m="",f=0,g="FLOAT32ARRAY",y=null;if(t===J.NEEDLEMAN_WUNSCH||t===J.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce((e,t)=>Math.min(e,t),p[0]),t=p.reduce((e,t)=>Math.max(e,t),p[0]);i.range=t-e}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=z.MANHATTAN);let d=h.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=h.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),f=new Uint32Array(c*u);h.forEach((e,t)=>{f.set(e.arraySizes,t*u)});const g=1e4,y=100,b=h.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,S=u*(u-1)/2,A=Math.ceil(S/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${A} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${u}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${u}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,h.map(e=>e.maxEntryLen),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),R=Math.floor(S/g);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?S-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce((e,t)=>e+t.sourceArraySize,0),H=h.reduce((e,t)=>e+t.suppInfoSize,0),B=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let G=F;const D=15&F;0!==D&&(G+=16-D);const V=s.createBuffer({label:"compute info buffer",size:G,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let j=0;new Uint32Array(W,j,g).set(I),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(L),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(N),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(P),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,f.length).set(f),j+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,j,c).set(o),j+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,j,n).set(e.flatSourceArray),j+=n*t.BYTES_PER_ELEMENT}V.unmap();const U=H*Uint32Array.BYTES_PER_ELEMENT;let q=U;const Y=15&U;0!==Y&&(q+=16-Y),q=Math.max(q,16);const K=s.createBuffer({label:"supp info buffer",size:q,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=K.getMappedRange();let X=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(Z,X,e.suppInfoBuffer.length).set(e.suppInfoBuffer),X+=e.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ee=Q;const ie=15&Q;0!==ie&&(ee+=16-ie);const re=s.createBuffer({label:"results buffer",size:ee,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(_),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,B);o+=B*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,B);o+=B*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,g);o+=g*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,g).every(e=>1===e);const u=c.reduce((e,t)=>e+t,0),h=new Uint32Array(u),d=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(r.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(h),ce.push(d),ue.push(p),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),pe=new Uint32Array(de),me=new Uint32Array(de),fe=new Float32Array(de);let ge=0;for(let e=0;e<le.length;e++)pe.set(le[e],ge),me.set(ce[e],ge),fe.set(ue[e],ge),ge+=le[e].length;return V.destroy(),K.destroy(),re.destroy(),ae.destroy(),{i:pe,j:me,distance:fe}})}function oe(e,t,n,i){return e.map((e,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${ee[e](t[i],i)}\n        }\n      `).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${e.length}>;\n        ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n        ${X[i](e.length)}\n      }\n    \n    `}let re=0;const se="cliffsDf",ae=new u.Subject,le="SALI",ce="line index",ue=["From","To"],he="filterCliffs";async function de(e,t,i,o,l,c,u,h,d,p,m,f,g,y,b,v,w){re++;const C=c/100;let S,A=!1;const x=f.inputs,M=await f.apply({[x[0].name]:t,[x[1].name]:u,...d.preprocessingFuncArgs??{}});let T=[];if(h===N){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{h=e,u.onmessage=t=>{setTimeout(()=>u.terminate(),100),e(t.data.res)},u.onerror=e=>{setTimeout(()=>u.terminate(),100),t(e)}}),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([M.entries],c,[1],"MANHATTAN",[u],[M.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),T=[t.embedX,t.embedY]}else T=await Z([M.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[M.options??{}]});if(T.length!==i.length)throw new Error("Number of axes names 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e=0;e<B.linesDf.rowCount;e++)B.lines.widths[e]=e===B.linesDf.currentRowIdx?3:1;F.linesToRender=B.lines;const n=B.linesDf.currentCol&&B.linesDf.currentCol.name===ue[1]?B.lines.to:B.lines.from,o=-1!==B.linesDf.currentRowIdx?B.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=B.linesDf.currentRowIdx;F.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,p=(n<o?n:o)+s/2-h/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+h,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],B.lines.from[n]),H.dataFrame.get(i[1],B.lines.from[n]),H.dataFrame.get(i[0],B.lines.to[n]),H.dataFrame.get(i[1],B.lines.to[n]));H.zoom(a,u,c,h),j.value?e.filter.and(L):!0===j.enabled&&e.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,o,a,l,c,u){const h=t.getPane("Cliff Details");s.empty(h.root);const 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n=B.linesDf.selection.clone();setTimeout(()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),B.linesDf.selection.copyFrom(n)):(B.linesDf.currentRowIdx!==t.id&&(B.linesDf.currentRowIdx=t.id,e.currentRowIdx=B.lines.from[t.id]),B.linesDf.selection.copyFrom(n));const i=B.linesDf.getSortedOrder(G.sortByColumns,G.sortTypes);G.scrollToCell(ue[0],i.indexOf(t.id))},500)}}),F.lineHover.pipe((0,k.debounceTime)(500)).subscribe(n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[B.lines.from[n.id],B.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)}),H.addProperty("similarityLimit","double",C),S=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",()=>s.divText("Cliff has not been selected"),!0),r.shell.o=e.root,e}(),H}var pe=n(6863),me=n(2003),fe=n(3516),ge=n(3151);function ye(e,t){const n=e=>o[e]??null,i=e=>{const t=s.columns.addNewString((e+1).toString());return o.push(t),t},o=[],r=e.length,s=a.DataFrame.create(r),l=t.getSeqHandler(e);for(let e=0;e<r;++e){const t=l.getSplitted(e);for(let o=0;o<t.length;++o){const r=t.getCanonical(o);(n(o)||i(o)).set(e,r,!1)}}return s}var be,ve=n(439),we=n(4971);async function Ce(e){const t=(await(0,we.pj)()).getMonomerLib(),n=[],i={},o=e.map(e=>t.getMonomer("PEPTIDE",e)?.smiles??""),s=a.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){i[e[t]]=t;const a=o[t],l=""===a?new Array(o.length).fill(0):(await r.chem.getSimilarities(s,a)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(be||(be={}));var Se=n(9192);class Ae{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class xe extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ae}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Me,Te,Ee;function _e(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Ie(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function Le(e,t,i,o,c,u,h,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==u.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??r.shell.tableView(e.name)??r.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let S;try{const A=_e(e);function x(n,o,r){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!S&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:f.scatterPlotName??Ie(t,i)}))),f[l.YP]&&(S?.root&&s.setUpdateIndicator(S.root,!1),c.init(e=>r[0]?r[0][e]:void 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e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[r]:o[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map(e=>e.entries),i,a,d,h,m,f[l.vb]?void 0:x))}catch(e){s(e)}}),y=await g;return C.close(),p.unsubscribe(),y}const T=await M();if(p&&T){const E=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(T[0],T[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>_[e].toString()),S&&(S.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{E.close()}}if(T){const N=e.columns.byName(A[0]),P=e.columns.byName(A[1]);if(N.init(e=>T[0][e]),P.init(e=>T[1][e]),g)try{const R=g.inputs[0].name,$=g.inputs[1].name;await g.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){r.shell.error("Post-processing failed"),console.error(O)}if(S)return s.setUpdateIndicator(S.root,!1),S.helpUrl="/help/compute/sequence-space",S}}catch(k){r.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),S&&s.setUpdateIndicator(S.root,!1)}};return new Promise(async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Me||(Me={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Te||(Te={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Ee||(Ee={})),Object.prototype.toString;var Ne=n(6873),Pe=n(4356),Re=n(6717),$e=n(4025),Oe=n(4870),ke=n(3856),He=n(6882),Be=n(7278),Fe=n(5553),Ge=n(6642),De=n(3599),Ve=n(673),We=n(8312);class je extends Ge.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,qr.logger),(0,we.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,We.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var Ue=n(4139);const qe=me.zS;function ze(e){const t=!R().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class Ye extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=qr.seqHelper}getRendererBack(e){const[t,n,i]=(0,Ge.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Fe.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,Ge.BG)(r);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(qr.properties?qr.properties.maxMonomerLength:4)??50;if(ke.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(ke.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new He.Jy(a,l,qr.logger,d,()=>{const{font:e,fontWidth:t}=He.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:qe}}),l.temp[".mm.cellRenderer.settingsChanged"],Ve.s.true,p.init().then(()=>{})),p.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class Ke extends je{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",u=this.tableCol.tags[me.gp.separator],h=this.tableCol.meta.units;i=(0,He.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[$e.j.notationProvider]?.separatorSplitter??(0,Be.Iv)(h,u),f=m(d),g=m(p),y=R().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),b=R().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),v=this.tableCol.getTag(me.gp.alphabet);Xe(e,t,n,i,o,y,b,v===me.YI.RNA||v===me.YI.DNA?De.o.NUCLEOTIDE:De.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Ge.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new Ke(t,n)),o}}class Ze extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ue.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){Ke.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Xe(e,t,n,i,o,r,s,a,l,c,u){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ve.b9[me.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const h=e.measureText(ze(r).join("")),d=e.measureText(ze(s).join("")),p=Math.max(h.width,d.width);c&&(i=p+4*r.length,e.canvas.width=p+4*r.length);let m=Math.max(t,t+(i-(p+4*r.length))/2)+5;const f=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=He.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=He.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,ke.oZ)(e,n,m,f-h,i,o,{color:d,pivot:0,left:!0}),p=(0,ke.oZ)(e,c,m,f+h,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),u&&(u[t]=Je(n,c,d,r,f,h,o))}else m=(0,ke.oZ)(e,n,m,f,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Je(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(ze([e]).join("")).width,u=l.measureText(ze([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,ke.oZ)(l,e,0,o-r,h,s,{color:n,pivot:0,left:!0}),(0,ke.oZ)(l,t,0,o+r,h,s,{color:i,pivot:0,left:!0}),a}var Qe,et=n(8070),tt=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Qe||(Qe={}));const nt=new class{constructor(){this.regionTypes=[Qe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=tt.fH.Entropy,this.filterSource=tt.Fo.filterSource}};var it=n(7602),ot=n(250);const rt=Qe;var st,at;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(st||(st={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(at||(at={}));const lt=nt;class ct extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(at.skipEmptyPositions,lt.skipEmptyPositions,{category:st.DATA}),this.regionTypes=this.stringList(at.regionTypes,lt.regionTypes,{category:st.DATA,choices:Object.values(rt).filter(e=>e!=rt.Unknown)}),this.chains=this.stringList(at.chains,lt.chains,{category:st.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(at.fitWidth,lt.fitWidth,{category:st.LAYOUT}),this.positionWidth=this.float(at.positionWidth,lt.positionWidth,{category:st.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(at.positionHeight,lt.positionHeight,{category:st.LAYOUT,choices:Object.keys(tt.fH)}),this.filterSource=this.string(at.filterSource,lt.filterSource,{category:st.BEHAVIOR,choices:Object.values(tt.lT)}),this.viewSyncer=new it.g(qr.logger)}static viewerCounter=-1;viewerId=++ct.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case at.regionTypes:case at.chains:this.setData(this.regions)}switch(e.name){case at.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case at.fitWidth:case at.positionWidth:this.calcSize();break;case at.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.positionHeight]:this.positionHeight});this.calcSize();break;case at.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;qr.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){qr.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){qr.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=s.table(this.chains,e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(tt.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),qr.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){qr.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[ot.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ot.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(at.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[ot.n5.filterSource]:this.filterSource})}}})}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,et.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class ut{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ht{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new ht(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ut);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ut);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function pt(e,t,n="Morgan",i=1,o=.6){const r=e.length,s=qr.seqHelper.getSeqHandler(e),l=Array(r);let c=1;const u=new Map,h=e.categories,d=e.getRawData();for(let t=0;t<r;t++){if(null==h[d[t]]||e.isNone(t)){l[t]=null;continue}l[t]="";const n=s.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);u.has(i)||(u.set(i,String.fromCharCode(c)),c++),l[t]+=u.get(i)}}let p={};if(t===pe.Z.MONOMER_CHEMICAL_DISTANCE||t===pe.Z.NEEDLEMANN_WUNSCH){const e=Array.from(u.keys()),r=await async function(e,t="Morgan"){const n=(await(0,we.pj)()).getMonomerLib(),i=new Array(e.length).fill(0).map(()=>new Array(e.length).fill(0)),o={},r=e.map(e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||""),s=a.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!s)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await Ce(e);const l=a.Column.fromStrings("smiles",r),c=(a.DataFrame.fromColumns([l]),(await s.apply({col:l,fingerprintType:t}))?.entries);if(!c)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await Ce(e);for(let t=0;t<c.length;++t)if(i[t][t]=1,o[e[t]]=t,c[t])for(let e=t+1;e<c.length;++e)c[e]&&(i[t][e]=i[e][t]=(0,H.$1)(c[t],c[e]));return{scoringMatrix:i,alphabetIndexes:o}}(e,n),s={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{s[u.get(e)]=t});const c=l.reduce((e,t)=>Math.max(e,t?.length||0),0);p={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:c},t===pe.Z.NEEDLEMANN_WUNSCH&&(p.gapOpen=i,p.gapExtend=o)}return{seqList:l,options:p}}var mt=n(4954);function ft(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))}),t}function gt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=qr.seqHelper.getSeqHandler(e.seqCol),r=o.defaultBiotype,a=bt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),r,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(vt(i)),t.append(yt("Activity delta",Math.abs(n[0]-n[1]))),t.append(yt("Cliff",e.sali)),t}function yt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function bt(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=qr.monomerLib;return Xe(r,0,0,0,30,R().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),R().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function vt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function wt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(me.gp.separator,e.col(t[0]).getTag(me.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class Ct extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class St extends Ct{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[pe.Z.NEEDLEMANN_WUNSCH,pe.Z.HAMMING,pe.Z.LEVENSHTEIN,pe.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,me.gp.aligned,me.gp.separator,me.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",pe.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===pe.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===pe.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===pe.Z.NEEDLEMANN_WUNSCH}}const At={gapPenalty:1,matchScore:1,gapSymbol:ve.b9[ve.Hi.FASTA],localAlignment:!1};class xt extends St{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new u.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Oe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Oe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await pt(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new D).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=a.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...At,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let u=i.localAlignment?c[0]:r,h=i.localAlignment?c[1]:s,d=new Array(0),p=new Array(0);for(;u>0&&h>0;){const n=Math.max(a[u-1][h-1],a[u-1][h],a[u][h-1]);a[u][h]==a[u-1][h-1]+i.matchScore&&n==a[u-1][h-1]?(d.push(e.getCanonical(u-1)),p.push(t.getCanonical(h-1)),u-=1,h-=1):a[u][h]==a[u-1][h]-i.gapPenalty?(p.push(i.gapSymbol),d.push(e.getCanonical(u-1)),u-=1):a[u][h]==a[u][h-1]-i.gapPenalty?(d.push(i.gapSymbol),p.push(t.getCanonical(h-1)),h-=1):(d.push(e.getCanonical(u-1)),p.push(t.getCanonical(h-1)),u-=1,h-=1)}d=[...R().count(0).take(u).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?R().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],p=[...R().count(0).take(h).map(e=>t.getCanonical(e)),...p.reverse(),...i.localAlignment?R().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const m=u,f=h;return m>f?p=[...new Array(m-f).fill(i.gapSymbol.valueOf()),...p]:d=[...new Array(f-m).fill(i.gapSymbol.valueOf()),...d],p.length>d.length?d.push(...new Array(p.length-d.length).fill(i.gapSymbol.valueOf())):p.push(...new Array(d.length-p.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:p.join(""),seq1Splitted:new Be.Mu(d,i.gapSymbol),seq2Splitted:new Be.Mu(p,i.gapSymbol)}}(c,u),d=bt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(vt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",()=>t,!0),r.shell.o=p.root}}class Mt extends St{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new u.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Oe.Kd)(i,t.name,450,30),(0,Oe.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await pt(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new G(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[u(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Tt,Et=n(5433),_t=n(3890),It=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(Tt||(Tt={}));class Lt{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Nt extends Lt{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends Nt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(Tt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(Tt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(Tt.TYPE)&&-1!==e.indexOf(Tt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Tt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Tt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Tt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Tt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Tt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt extends Nt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Pt(e);if($t.isMolfileV3K(e))return new Rt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return Rt.isValidMolfile(e)}}var Ot=n(6197),kt=n(9124),Ht=n(3527);class Bt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Bt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ft extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t,n,i,o){super(e,t,i,void 0,void 0,void 0,n),this.at={},o.forEach(e=>{this.at[e]="H"})}}class Gt extends Bt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Dt extends Bt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Vt extends Bt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Wt extends Bt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class jt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Wt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new jt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Ut={[De.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[De.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[De.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[De.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[De.o.CHEM]:{R:"#eeeeee"},[De.o.BLOB]:{B:"#999999",G:"#e2e2e2"}};class qt{constructor(e,t=[],n={}){this.onItemChanged=new u.Subject,this.onAddingItemChanged=new u.Subject,this.onItemAdded=new u.Subject,this.onItemRemoved=new u.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=s.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach(t=>{e[t]=this.addingItemInputs[t].value}),e}getItemDiv(e={},t){var n,i;const o=[],r={};let l=null;for(const c of this.properties){void 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o;c=s.icons.delete(()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()},this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",o}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const zt={A:new j.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new j.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new j.A(new 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new j.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;if(!Yt[t])return null;const o=Yt[t];let r=0,s=null;for(const[e,t]of Object.entries(o)){const o=(0,H.$1)(i,t);o>r&&o>=n&&(r=o,s=e)}return s}var Zt,Xt=n(857),Jt={};Jt.styleTagTransform=S(),Jt.setAttributes=b(),Jt.insert=g().bind(null,"head"),Jt.domAPI=m(),Jt.insertStyleElement=w(),d()(Xt.A,Jt),Xt.A&&Xt.A.locals&&Xt.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Zt||(Zt={}));const Qt={[Zt.MONOMER]:a.COLUMN_TYPE.STRING,[Zt.SYMBOL]:a.COLUMN_TYPE.STRING,[Zt.NAME]:a.COLUMN_TYPE.STRING,[Zt.R_GROUPS]:a.COLUMN_TYPE.STRING,[Zt.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Zt.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Zt.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Zt.AUTHOR]:a.COLUMN_TYPE.STRING,[Zt.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Zt.ID]:a.COLUMN_TYPE.INT,[Zt.META]:a.COLUMN_TYPE.STRING,[Zt.SOURCE]:a.COLUMN_TYPE.STRING};async function en(e){const t=await tn(e);if(e.length!==t.rowCount)throw new Error(`Monomers length ${e.length} does not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>dn(t.rows.get(n))))}async function tn(e){try{const t=a.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(Qt))if(t.columns.addNew(e,n),e===Zt.R_GROUPS)for(const e of i)t.columns.addNew(e,a.COLUMN_TYPE.STRING);t.col(Zt.SYMBOL).semType="Monomer",t.col(Zt.SYMBOL).setTag(ke.Mn.applyToBackground,"true"),t.col(Zt.SYMBOL).setTag(ve.qE.polymerTypeColumnName,Zt.POLYMER_TYPE);const o=a.TaskBarProgressIndicator.create("Creating Monomers DataFrame...");for(let n=0;n<e.length;n++){n%20==0&&o.update((n+1)/e.length*100,"Creating Monomers DataFrame...");const r=()=>{let o=cn(e[n].rgroups,e[n].smiles,e[n].molfile);o=on(o),e[n].rgroups=an(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?sn(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(Zt.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(Zt.MONOMER).semType=a.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=a.SEMTYPE.MOLECULE}),t}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}}class nn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Zt.NAME).width=100,this.tv.grid.col(Zt.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=ge.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new ln(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(Zt.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await Hn.getInstance();await e.awaitLoaded(),this.instance=new nn(e)}return this.instance}static async getNewInstance(){const e=await Hn.getInstance();return await e.awaitLoaded(),new nn(e)}async createNewMonomerLib(e,t,n){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const i=(await this.monomerLibManamger.getProviders()).find(t=>t.name===e);if(!i)throw new Error(`Provider ${e} not found`);const o=n.map(e=>({...e,lib:void 0,wem:void 0}));await i.addOrUpdateLibrary(t,o),await this.monomerLibManamger.loadMonomerLib(!1),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=await this.monomerLibManamger.getAvaliableLibraryNames(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);l.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=(await this.monomerLibManamger.getProviders()).map(e=>e.name),a=s.input.choice("Storage",{items:o,value:o[0],nullable:!1,tooltipText:"Select storage provider for the new library"});1===o.length&&(a.readOnly=!0);const l=s.dialog("Create New Library").add(a).add(n).addButton("Create",async()=>{const t=i(n.value);if(t)r.shell.warning(t);else if(a.value){try{await this.createNewMonomerLib(a.value,n.value,e??[])}catch(e){r.shell.error("Error creating library"),console.error(e)}l.close()}else r.shell.warning("Please select storage provider")}).show();l.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}_contextMenuSub=null;async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this._contextMenuSub?.unsubscribe(),this._contextMenuSub=r.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>dn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>dn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await dn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})}),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter(e=>e.name===nn.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(r.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?r.shell.v=e:nn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=await this.monomerLibManamger.getAvaliableLibraryNames();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){r.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const o=s.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=s.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=s.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),u=s.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>dn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await dn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});s.tooltip.bind(u,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const h=s.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return r.shell.error("No library selected");let t=null;try{const n=await(0,we.pY)(await this.monomerLibManamger.getProviders(),e);if(!n)throw new Error(`Library ${e} not found in any provider`);t=await n.getLibraryAsString(e)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return r.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([o,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=nn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await dn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{let t=null;const n=await this.monomerLibManamger.getProviders();if(0===n.length)throw new Error("No monomer library providers available");if(e){if(t=await(0,we.pY)(n,e),!t)throw new Error(`Library ${e} not found in any provider`)}else t=n[0],e=(await t.listLibraries())[0];if(this.activeMonomerLib=await this.monomerLibManamger.readSingleLibrary(t.name,e),!this.activeMonomerLib)return r.shell.error(`Library ${e} not found`),a.DataFrame.create();const i=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await tn(i)}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame,t=this.libInput.value;if(e&&t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await(0,we.pY)(await this.monomerLibManamger.getProviders(),t);if(!n)throw new Error(`Library ${t} not found in any provider`);const i=(await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>dn(e.rows.get(n))))).map(e=>({...e,lib:void 0,wem:void 0}));await n.addOrUpdateLibrary(t,i),await this.monomerLibManamger.loadMonomerLib(!0),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function on(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const rn=["alternateId","capGroupName","capGroupSMILES","label"];function sn(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function an(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(rn,e),n=sn(t,"capGroupSMILES"),i=sn(t,"alternateId"),o=sn(t,"capGroupName"),r=sn(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class ln{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new pn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",async()=>{const e=this.validateInputs();e?r.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=cn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Kt(hn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new qt(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?r.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new qt(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=an(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&Kt(hn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=cn(e.rgroups,e.smiles,e.molfile),n=r.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){const i=await(0,we.pY)(await this.monomerLibManager.getProviders(),t);if(!i)return void r.shell.error(`Library ${t} not found in any provider`);const o=s.divV(e.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),a=e.length>1,l=a?`Are you sure you want to remove monomers ${e.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${e[0].symbol} from ${t} library?`,c=s.dialog("Remove Monomer"+(a?"s":"")).add(s.h1(l)).add(o).addButton("Remove",async()=>{await i.deleteMonomersFromLibrary(t,e),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${a?"s":""} ${e.map(e=>e.symbol).join(", ")} ${a?"were":"was"} successfully removed from ${t} library`),c.close()}).show()}async addMonomerToLib(e,t){const n=this.getMonomersDataFrame();if(!n)return void r.shell.error("No monomer library loaded");const i=n?.col(Zt.POLYMER_TYPE)?.toList()??[],o=n?.col(Zt.SYMBOL)?.toList()??[],a=n?.col(Zt.MONOMER)?.toList()??[];if(i.length!==o.length||i.length!==a.length)return void r.shell.error("Monomer library data frame is corrupted");const l=i.findIndex((t,n)=>t===e.polymerType&&o[n]===e.symbol),c=a.findIndex(t=>t===e.smiles),u=async()=>{try{const n=await(0,we.pY)(await this.monomerLibManager.getProviders(),t);if(!n)return void r.shell.error(`Library ${t} not found in any provider`);await n.updateOrAddMonomersInLibrary(t,[{...e,lib:void 0,wem:void 0}]),await this.monomerLibManager.loadMonomerLib(!0),await this.refreshTable(e.symbol),this._molChanged=!1,r.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){r.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let h=null,d="";if(l>=0)h=this.getMonomerInfoTable(await dn(n.row(l))),d=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((c??-1)>=0){const e=await dn(this.getMonomersDataFrame().rows.get(c));h=this.getMonomerInfoTable(e),d=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(h){const e=s.dialog("Save Monomer").add(s.divText(d)).add(h).addButton("Save",()=>{e.close(),u()}).show()}else await u()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!r.chem.checkSmiles(e))return void r.shell.warning("Invalid SMILES");e=cn([],e);let t=r.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=un(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function cn(e,t,n){const i=!t||!r.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(o,e),o=on(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function un(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function hn(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=sn(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)}),n}async function dn(e){let t;try{t=JSON.parse(e.get(Zt.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Zt.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=un(i)}catch(e){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Zt.NATURAL_ANALOG);const s=e.get(Zt.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Zt.R_GROUPS)??"[]"),!o&&s){const e=await Kt(hn(n,l),s);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Zt.SYMBOL),name:e.get(Zt.NAME),molfile:i,smiles:n,polymerType:s,monomerType:e.get(Zt.MONOMER_TYPE),naturalAnalog:o,id:e.get(Zt.ID),rgroups:l,meta:t,author:e.get(Zt.AUTHOR),createDate:e.get(Zt.CREATE_DATE)}}class pn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}const mn=/.*\|\$.*R.*\$\|/,fn=/\[R(\d+)\]/,gn=/\[R(\d+)\]/g,yn=/\[\*:(\d+)\]/g;function bn(e,t){const n=Array.from(e.matchAll(gn)).map(e=>e[1]),i={name:"Explicit SMILES Monomer",smiles:e,polymerType:t??"CHEM",molfile:"",rgroups:n.map(e=>({label:`R${e}`,capGroupName:"H",capGroupSmiles:`[*:${e}][H]`,alternateId:`R${e}-H`})),author:"Datagrok auto-generated",id:0,createDate:null,monomerType:"Backbone"};try{let t=e;i.rgroups.forEach(e=>{const n=e.label.substring(1);t=t.replace(`[R${n}]`,`[*:${n}]`)});const n=un(r.chem.convert(t,r.chem.Notation.Smiles,r.chem.Notation.MolBlock));i.molfile=n,i.smiles=t}catch(t){qr.logger.error(`getMonomerFromRSmiles: cannot convert SMILES to Molfile: ${e}\n${t}`)}return i}const vn=/[\w()]+/,wn=RegExp(String.raw`\(${vn}(,${vn})+\)`),Cn=e=>{const t=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,t,e),t},Sn=new Ht.Mi([255,255,255]),An=new Ht.Mi([0,0,0]),xn=.7*(0,K.wQ)(Sn);class Mn{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){const t=Object.keys(this._monomers[e]);return this._smilesMonomerCache[e]&&t.push(...Object.keys(this._smilesMonomerCache[e])),t}_smilesMonomerCache={};addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;t==ve._S||t===ve.b9[ve.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any");const o=function(e,t){try{if(mn.test(e)){const n=e.split("|$"),i=n[0].trim(),o=n[1],r=Array.from(o.matchAll(/R(\d+)/g)),s=Array.from(i.matchAll(/(\*)/g));if(r.length!==s.length)return null;let a=i.replaceAll(/\[\*\]/g,"*");const l=r.map(e=>e[1]);for(let e=0;e<l.length;e++){const t=l[e];a=a.replace("*",`[R${t}]`)}return bn(a,t)}let n=e;const i=Array.from(e.matchAll(yn));for(const e of i){const t=e[0],i=e[1];n=n.replace(t,`[R${i}]`)}if(fn.test(n))return bn(n,t)}catch(t){qr.logger.error(`smiles2Monomer: cannot parse SMILES: ${e}\n${t}`)}return null}(t,e);if(o){this._smilesMonomerCache[e]=this._smilesMonomerCache[e]??{};const i=this._smilesMonomerCache[e],r=Object.keys(i).length+1;i[t]=`#${e[0]}${r}`;const s={...o,symbol:i[t]},a=new Ft((0,Be.MD)(e),s.symbol,t,`SMILES Monomer ${s.symbol}`,s.rgroups.map(e=>e.label));return s.wem=a,n[s.symbol]=s,s}return n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){this._smilesMonomerCache[e]?.[n]&&(n=this._smilesMonomerCache[e][n]);const t=this._monomers[e];i=t?.[n]??null}else{qr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,kt.fA)(e,t),o=(0,Ot.Y)(n);let r=this.getMonomer(o,i);if(r&&n==De.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==De.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ve._S||"*"==i?s=r.wem=new Gt(n):n===De.o.NUCLEOTIDE&&"N"===i||n===De.o.AA&&"X"===i||(De.o.CHEM,0)||wn.test(i)?s=r.wem=new Dt(n,i):r.lib||(s=r.wem=new Vt(n,i,this.isEmpty)),s||(s=r.wem=jt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Ot.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),r=this.getMonomer(n,t);if(r){const e=r.symbol,[t,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?Cn(r.molfile):r.smiles?s.divV([Cn(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=ve._S){let e=r.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(e))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Ht.Mi([...o.map(e=>e+1)]),s=(0,K.KE)(r,Sn)/((0,K.wQ)(r)*(0,K.wQ)(Sn)),l=i(n.backgroundcolor),c=new Ht.Mi([...l.map(e=>e+.01)]);let u;u=(0,K.KE)(c,Sn)/((0,K.wQ)(c)*(0,K.wQ)(Sn))<s?l:o;let h=new Ht.Mi(u);const d=(0,K.wQ)(h);return d>xn&&(h=(0,K.dC)(An,h,xn/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Ot.Y)(e),r=this.getMonomer(o,t);let s;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){qr.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(s=e[i])}if(!s){const t=Ut[e],n=t?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!s&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Tn=n(5488),En={};En.styleTagTransform=S(),En.setAttributes=b(),En.insert=g().bind(null,"head"),En.domAPI=m(),En.insertStyleElement=w(),d()(Tn.A,En),Tn.A&&Tn.A.locals&&Tn.A.locals;class _n extends Mn{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}_monomerSets=null;getMonomerSet(e){const t=(0,Ot.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}async updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);if(Object.entries(this.duplicateMonomers).length>0){const e=await(0,Pe.u)();this.assignDuplicatePreferences(e)}else this._duplicatesHandled=!0;this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new In(e,`override: ${++_n.overrideCounter}, ${t}`,this)}}class In extends Mn{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Ln=n(8604),Nn=n(7433),Pn=n.n(Nn),Rn=n(1913),$n=n.n(Rn);class On{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Pn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});$n()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!=n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}class kn{fileValidator;libHelper;logger;get LIB_PATH(){return"System:AppData/Bio/monomer-libraries/"}get SETS_PATH(){return"System:AppData/Bio/monomer-sets/"}static HELM_JSON_SCHEMA_PATH="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json";static _instance=null;filesPromise=Promise.resolve();name=we.ic;_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.logger=n}static async getInstance(e,t){if(null==this._instance){const n=await r.dapi.files.readAsText(kn.HELM_JSON_SCHEMA_PATH),i=JSON.parse(n),o=new On(i);kn._instance=new kn(o,e,t),kn._instance.refreshLists()}return kn._instance}toLog(){return"MonomerLibFileManager"}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async refreshLists(){await Promise.all([this.updateValidLibList(),this.updateValidSetList()])}async addOrUpdateLibraryString(e,t){e=e.endsWith(".json")?e:`${e}.json`;try{await this.validateAgainstHELM(t,e),await r.dapi.files.writeAsText(this.LIB_PATH+`${e}`,t),await this.updateValidLibList(),await r.dapi.files.exists(this.LIB_PATH+`${e}`)?r.shell.info(`Added ${e} HELM library`):r.shell.error(`Failed to add ${e} library`)}catch(t){this.logger.error(t),r.shell.error(`Failed to add ${e} library`)}}async addOrUpdateLibrary(e,t){const n=JSON.stringify([...t.map(e=>({...e,wem:void 0,lib:void 0}))],null,2);await this.addOrUpdateLibraryString(e,n)}get loadPromise(){return this.filesPromise}async listLibraries(){return this.validLibList}async listSets(){return this.validSetList}async loadLibraries(e,t=!1){let n=[];e=e.map(e=>e.endsWith(".json")?e:`${e}.json`);const i=t?e:e.map(e=>this.LIB_PATH+e),o=[];for(let e=0;e<i.length;e++){const t={};try{const o=await r.dapi.files.readAsText(i[e]);n=JSON.parse(o),n.forEach(e=>{const n=e.polymerType,i=e.symbol;t[n]||(t[n]={}),t[n][i]=e})}catch(t){this.logger.error(`Failed to load monomer library file: ${i[e]}`),this.logger.error(t);continue}finally{o.push(t)}}return o}async loadSets(e){const t=[],n=this.libHelper.getMonomerLib();for(const i of e){const e=i.endsWith(".json")?i:`${i}.json`,o=this.SETS_PATH+e;try{const e=await r.dapi.files.readAsText(o),i=JSON.parse(e),s=i.description,a=Object.entries(i.placeholders).map(([e,t])=>{const i=e,o=t.polymerType,r=t.monomerType,s=t.set;return new we.lH(n,i,o,r,s)});t.push(new we.YS(s,a))}catch(e){this.logger.error(`Failed to load monomer set file: ${o}`),this.logger.error(e);continue}}return t}async deleteLibrary(e){const t=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.delete(this.LIB_PATH+t),await this.updateValidLibList()}async deleteSet(e){const t=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.delete(this.SETS_PATH+t),await this.updateValidSetList()}async addOrUpdateSetString(e,t){const n=e.endsWith(".json")?e:`${e}.json`;await r.dapi.files.writeAsText(this.SETS_PATH+n,t),await this.updateValidSetList()}async addOrUpdateSet(e,t){const n=JSON.stringify(t,null,2);await this.addOrUpdateSetString(e,n)}async deleteMonomersFromLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,o=await r.dapi.files.readAsText(i);let s=JSON.parse(o);s=s.filter(e=>!t.some(t=>e.polymerType===t.polymerType&&e.symbol===t.symbol));const a=JSON.stringify(s,null,2);await r.dapi.files.writeAsText(i,a),await this.updateValidLibList()}validLibList=[];libListHasChanged(e){const t=this.validLibList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}validSetList=[];setListHasChanged(e){const t=this.validSetList;return e.length!==t.length||e.some((e,n)=>e!==t[n])}async getLibraryAsString(e){const t=e.endsWith(".json")?e:`${e}.json`;return r.dapi.files.readAsText(this.LIB_PATH+t)}async getSingleLibrary(e){return(await this.loadLibraries([e]))?.[0]}async getSingleLibraryWithFullPath(e){return(await this.loadLibraries([e],!0))?.[0]}async updateOrAddMonomersInLibrary(e,t){const n=e.endsWith(".json")?e:`${e}.json`,i=this.LIB_PATH+n,o=await r.dapi.files.readAsText(i),s=JSON.parse(o);for(const e of t){const t=s.findIndex(t=>t.polymerType===e.polymerType&&t.symbol===e.symbol);-1!==t?s[t]={...e,lib:void 0,wem:void 0}:s.push({...e,lib:void 0,wem:void 0})}const a=JSON.stringify(s,null,2);await r.dapi.files.writeAsText(i,a),await this.updateValidLibList()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await r.dapi.files.readAsText(this.LIB_PATH+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.validLibList=i,await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${this.LIB_PATH}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")||t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.validSetList=i,this.libHelper.loadMonomerSets(!0)),this.logger.debug(`${e}, OUT`),this._onChanged.next()}),this.logger.debug(`${e}, end`),this.filesPromise}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(this.LIB_PATH).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.LIB_PATH.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(this.SETS_PATH).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(this.SETS_PATH.length))}}class Hn{logger;_monomerLib=new _n({},"MAIN");_monomerSets=new we.YS("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_providersDataChanged=new u.Subject;get providersDataChanged(){return this._providersDataChanged}_fileUploadRequested=new u.Subject;get fileUploadRequested(){return this._fileUploadRequested}requestFileUpload(){this._fileUploadRequested.next()}_selectionChanged=new u.Subject;get librarySelectionChanged(){return this._selectionChanged}notifyLibrarySelectionChanged(){this._selectionChanged.next()}async getAvaliableLibraryNames(e=!1){const t=await this.getProviders(),n=[];for(const i of t){e&&await i.refreshLists();const t=await i.listLibraries();n.push(...t)}return n}async refreshValidLibraryLists(){const e=await this.getProviders();await Promise.all(e.map(async e=>e.refreshLists()))}async getAvailableLibrariesPerProvider(){const e=await this.getProviders(),t=new Map;for(const n of e){const e=await n.listLibraries();t.set(n.name,e)}return t}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getProviders();return await Promise.all(e.map(async e=>e.loadPromise)),await this.loadLibrariesPromise,!0})(),(async()=>(await(0,et.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}_monomerLibProviders=null;async getProviders(){if(null==this._monomerLibProviders){const e=a.Func.find({tags:["monomer-lib-provider"]});this._monomerLibProviders=await Promise.all(e.map(async e=>await e.apply({}))),this._monomerLibProviders.push(await kn.getInstance(this,qr.logger)),a.debounce((0,u.merge)(...this._monomerLibProviders.map(e=>e.onChanged)),200).subscribe(()=>{this._providersDataChanged.next()})}return this._monomerLibProviders}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Hn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Hn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const t=await(0,Pe.u)(),i=await this.getProviders(),o=await Promise.all(i.map(async e=>e.listLibraries()));o.forEach((e,n)=>{o[n]=e.filter(e=>{const n=!t.exclude.includes(e),i=0===(t.explicit?.length??0)||t.explicit.includes(e);return n&&i})});let s=0;const a=[];for(let e=0;e<i.length;e++){const t=i[e],l=o[e];try{const e=await t.loadLibraries(l);for(let t=0;t<e.length;t++)a.push(new _n(e[t],l[t]))}catch(e){r.shell.warning(`Loading monomer libraries from provider '${t.name}' failed: `),this.logger.error(`Loading monomer libraries from provider '${t.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}n.update(Math.round(100*++s/i.length),`Loading monomers ${s}/${i.length}`)}this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const t=await this.getProviders(),n=await Promise.all(t.map(async e=>e.listSets())),i=[];let o=0;for(let s=0;s<t.length;s++){const a=t[s],l=n[s];try{const e=await a.loadSets(l);for(let t=0;t<e.length;t++)i.push(e[t])}catch(e){r.shell.warning(`Loading monomer sets from provider '${a.name}' failed: `),this.logger.error(`Loading monomer sets from provider '${a.name}' failed: ${e instanceof Error?e.message:e.toString()}`)}e.update(Math.round(100*++o/t.length),`Loading monomer sets ${o}/${t.length}`)}this._monomerSets.updateSets(i)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async loadMonomerLibForTests(){await(0,Pe.E)(Ln.G),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}async readSingleLibrary(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadLibraries([t]);return 0===i.length?(this.logger.error(`Library '${t}' not found in provider '${e}'.`),null):new _n(i[0],t)}catch(e){return this.logger.error(`Loading monomer library '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}async readLibraryFromFilePath(e){const t=(await this.getProviders()).find(e=>e.name===we.ic);if(!t)throw new Error(`Provider '${we.ic}' not found.`);const n=await t.getSingleLibraryWithFullPath(e);if(!n)throw new Error(`Library at path '${e}' not found.`);return new _n(n,e)}async readSingleLibraryByName(e){const t=await this.getProviders(),n=await(0,we.pY)(t,e);return n?this.readSingleLibrary(n.name,e):(this.logger.error(`No provider found for library '${e}'.`),null)}async readSingleSet(e,t){const n=(await this.getProviders()).find(t=>t.name===e);if(!n)return this.logger.error(`Provider '${e}' not found.`),null;try{const i=await n.loadSets([t]);return 0===i.length?(this.logger.error(`Set '${t}' not found in provider '${e}'.`),null):i[0]}catch(e){return this.logger.error(`Loading monomer set '${t}' from provider '${n.name}' failed: ${e instanceof Error?e.message:e.toString()}`),null}}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>new Hn(qr.logger))()),e}}var Bn=n(1757),Fn=n.n(Bn);class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Dn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Gn(e));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,e),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Vn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Vn._instance||(Vn._instance=new Vn,await Vn._instance.refresh(),(await Hn.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Vn._instance.refresh())),Vn._instance.refresh(),Vn._instance}async refresh(){this.settings=await(0,Pe.u)();const e=await Hn.getInstance();await e.awaitLoaded(),this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Dn(n,this.monomers[t][n],o,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=s.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void r.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void r.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=s.input.choice("Default Library",{items:n,nullable:!0});s.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Pe.E)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else r.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=s.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}var Wn=n(3017),jn={};async function Un(){await Zn.showDialog()}async function qn(e=!0){return await Xn.showView(e)}jn.styleTagTransform=S(),jn.setAttributes=b(),jn.insert=g().bind(null,"head"),jn.domAPI=m(),jn.insertStyleElement=w(),d()(Wn.A,jn),Wn.A&&Wn.A.locals&&Wn.A.locals;class zn{_widget;get widget(){return this._widget}constructor(){}static instancePromise;libHelper;static async getInstance(){return null==zn.instancePromise&&(zn.instancePromise=(async()=>{const e=new zn,t=await(0,we.pj)();return e.libHelper=t,e._widget=await e.createWidget(),e})()),zn.instancePromise}static async reloadWidget(){const e=await zn.getInstance();e._widget=await e.createWidget()}_fileUploadSubscription=null;async createWidget(){const e=await this.getWidgetContent(),t=await(0,we.pj)();return this._fileUploadSubscription?.unsubscribe(),this._fileUploadSubscription=t.fileUploadRequested.subscribe(()=>this.promptToAddLibraryFiles()),new a.Widget(e)}async getWidgetContent(){const e=await Yn.createControlsForm();return Fn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&Fn()(e)&&Fn()(e).removeClass("ui-form-condensed")},200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=async t=>{const n=e.name;if((await t.listLibraries()).includes(n)&&!await new Promise(e=>{s.dialog("Confirm Library Update").add(s.divText(`Library '${n}' already exists. Do you want to overwrite it?`)).onOK(()=>e(!0)).onCancel(()=>e(!1)).show()}))return;const i=await e.text(),o=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await t.addOrUpdateLibraryString(n,i)}catch(e){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`),console.error(e)}finally{o.close()}},n=await this.libHelper.getProviders();if(0===n.length)return void r.shell.error("No monomer library providers available to add the library.");if(1===n.length)return void await t(n[0]);const i=s.dialog("Select storage for new monomer library"),o=s.input.choice("Storage",{items:n.map(e=>e.name),value:n[0].name,nullable:!1,tooltipText:"Storage provider for new monomer library"});i.add(o).onOK(async()=>{const e=n.find(e=>e.name===o.value);await t(e)}).show()}})}}class Yn{libHelper;userLibSettings;constructor(e,t){this.libHelper=e,this.userLibSettings=t,this.libHelper.providersDataChanged.subscribe(async()=>{await this.updateControlsForm()})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){qr.logger.debug("LibraryControlsForm.createControlsForm(), start");const e=await(0,Pe.u)(),t=await(0,we.pj)();return new Yn(t,e)._createControlsForm()}async _createControlsForm(){const e=await this.createLibraryControls(),t=s.wideForm(e,void 0);return Fn()(t).addClass("monomer-lib-controls-form"),t}async updateControlsForm(){const e=await this._createControlsForm();Fn()(".monomer-lib-controls-form").replaceWith(e)}async createLibraryControls(){return(await this.libHelper.getAvaliableLibraryNames()).map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;qr.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{Kn(i.value,e)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const o=s.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=s.icons.edit(async()=>{r.shell.v=await(await nn.getInstance()).getViewRoot(e)},"Edit monomer library");return s.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),qr.logger.debug(`${t}, libFileName = '${e}', end`),i}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Are you sure you want to delete library "${e}"?`)).onOK(async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await Kn(!1,e);const n=await(0,we.pY)(await this.libHelper.getProviders(),e);if(!n)throw new Error(`Cannot find provider for library ${e}`);await n.deleteLibrary(e),t.close()}catch(t){console.error(t),r.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}async function Kn(e,t){const n=await(0,Pe.u)();!function(e,t,n){t?e.exclude=e.exclude.filter(e=>e!==n):e.exclude.includes(n)||e.exclude.push(n)}(n,e,t),await(0,Pe.E)(n);const i=await(0,we.pj)();await i.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved"),i.notifyLibrarySelectionChanged()}class Zn{constructor(){}static _instance;dialog;closeDialogSubject$=new u.Subject;static async showDialog(){Zn._instance||(Zn._instance=new Zn,Zn._instance.closeDialogSubject$.subscribe(()=>{Zn._instance.dialog=void 0})),Zn._instance.dialog||(Zn._instance.dialog=await Zn._instance.getDialog()),Zn._instance.dialog.show()}async getDialog(){const e=(await zn.getInstance()).widget,t=await(0,we.pj)(),n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});Fn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>t.requestFileUpload(),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class Xn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=(await zn.getInstance()).widget,n=s.bigButton("Add",()=>this.libManager.requestFileUpload(),"Upload new HELM monomer library"),i=s.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),o=s.splitH([s.divV([t.root,s.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(o),this._view.name=Xn.viewName,e&&r.shell.addView(this._view),s.tools.waitForElementInDom(o).then(()=>{setTimeout(()=>{const e=Array.from(o.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;t.style.width=`${r}px`;const s=i-r;n.style.width=`${s}px`},100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe(()=>{try{const e=Xn._instance;e&&e._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return Xn._instance||(Xn._instance=new Xn),Xn._instance._duplicateManager||(Xn._instance._duplicateManager=await Vn.getInstance()),Xn._instance.libManager||(Xn._instance.libManager=await Hn.getInstance()),e&&Xn._instance._view&&Array.from(r.shell.views).find(e=>e.id&&e.id===Xn._instance._view.id)?(r.shell.v=Xn._instance._view,await Xn._instance._duplicateManager.refresh(),Xn._instance._view):(Xn.closeExistingViews(),Xn._instance.getView(e))}static closeExistingViews(){Array.from(r.shell.views).filter(e=>e.name===Xn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await Hn.getInstance();if(await t.awaitLoaded(),!t.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=c(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=await this.libManager.getAvaliableLibraryNames();function c(t){return t&&t.trim()?l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(c);const u=await this.libManager.getProviders();if(0===u.length)return void r.shell.error("No monomer library providers available to save the merged library.");const h=s.input.choice("Storage",{items:u.map(e=>e.name),value:u[0].name,nullable:!1,tooltipText:"Storage provider for saving new monomer library"});i.add(h).add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{a.Utils.download((()=>{let e=o.value.trim();return e||(e="New"),e.toLowerCase().endsWith(".json")||(e+=".json"),e})(),JSON.stringify(n))}).addButton("Save",async()=>{if(!o.value||!o.value.trim()||!h.value)return h.validate(),void o.validate();i.close();const e=o.value,t=JSON.stringify(n);this._view&&s.setUpdateIndicator(this._view.root,!0);try{const n=u.find(e=>e.name===h.value);await n.addOrUpdateLibraryString(e,t);const i=await(0,Pe.u)();i.exclude=l,await(0,Pe.E)(i),await this.libManager.loadMonomerLib(!0),await zn.reloadWidget()}catch(t){r.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Jn,Qn=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class ei{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe(e=>Qn(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=r.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),()=>Qn(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),()=>Qn(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),()=>Qn(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,ei.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Qn(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,et.cb)(c));const u=s.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return Qn(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Qn(this,void 0,void 0,function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Qn(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return Qn(this,void 0,void 0,function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ei.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Qn(this,void 0,void 0,function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}ei.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Jn||(Jn={}));var ti=n(966),ni=n(608),ii=n(1619);class oi{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${qr.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case ot.n5.fixWidth:case ot.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ri{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var si=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ai="-";class li extends je{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(ke.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ve._S||(a=ai);const l=a.split(ve.ot).map(e=>e&&e!==ve._S?e.trim():ai),c=l.map(e=>(0,me.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),u=c.map(t=>e.measureText(t).width),h=u.reduce((e,t)=>e+t,0);let d=t+(i-h)/2;const p=this.tableCol.getTag(ve.gp.alphabet),m=p===me.YI.RNA||p===me.YI.DNA?si.o.NUCLEOTIDE:si.o.AA;for(let a=0;a<c.length;a++){const h=l[a],p=this.getHelmType(r,m);let f=He.S$,g="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(p,h);f=e?.textcolor??f,g=e?.backgroundcolor??g}else f=this.monomerLib.getMonomerTextColor(p,h);s&&1==l.length&&(e.fillStyle=g,e.fillRect(t,n,i,o)),e.fillStyle=f,e.fillText(c[a],d,n+o/2,i),d+=u[a]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(ve.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),r=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==ve._S||i==ai)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===me.YI.RNA||n===me.YI.DNA?si.o.NUCLEOTIDE:si.o.AA,c=i.split(ve.ot).map(t=>{if(!t||t===ve._S||t===ai)return s.divText("gap");const n=this.getHelmType(e,l);return this.monomerLib.getTooltip(n,t)}),u=s.divH(c,{style:{alignItems:"top"}}),h=Array.from(u.querySelectorAll("canvas"));if(h.length>2){const e=Math.floor(550/h.length);h.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return s.tooltip.show(u,r,a),!0}getHelmType(e,t){let n=t;if((e.tableRowIndex??-1)>-1&&e.tableColumn?.getTag(ve.qE.polymerTypeColumnName)){const t=e.tableColumn.getTag(ve.qE.polymerTypeColumnName),i=e.tableColumn.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,Be.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Ge.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new li(t,n)),o}}class ci extends a.GridCellRenderer{get name(){return Ue.uF.MONOMER}get cellType(){return Ue.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){li.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){li.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class ui{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class hi extends Map{_onPropertyChanged=new u.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null==e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class di extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ui(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Se.AP)(e);r.shell.error(t),this.logger.error(t,void 0,n)}}var pi=n(6307),mi=n(5999),fi={};fi.styleTagTransform=S(),fi.setAttributes=b(),fi.insert=g().bind(null,"head"),fi.domAPI=m(),fi.insertStyleElement=w(),d()(mi.A,fi),mi.A&&mi.A.locals&&mi.A.locals;class gi extends a.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=qr.properties.tooltipWebLogo,n=this.seqCol.getTag(tt.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function yi(e,t,n,i){const o=qr.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null==r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null==s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const bi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(me.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class vi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??bi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(me.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(me.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${qr.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class wi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(me.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{qr.handleErrorUI(e)})}).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=s.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{qr.handleErrorUI(e)})});return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var Ci=n(8754);async function Si(e,t,n,i,o){const s=await async function(e,t,n,i,o){const s=ye(t,o),l=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),c=o.getSeqHandler(l).getSplitted(0),u=i===be.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ve._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return s}(c,s):i===be.SIMILARITY?await async function(e,t,n){const i=t.columns.toList(),o=await async function(e,t,n){e instanceof a.Column&&(e=ye(e,n).columns.toList());const i=(await(0,we.pj)()).getMonomerLib(),o=new Array(e.length),s=e[0].length,l=new Float32Array(s);for(let n=0;n<e.length;++n){const c=n<t.length?t.getCanonical(n):ve._S,u=i.getMonomer("PEPTIDE",c)?.smiles??"",h=e[n],d=h.getRawData(),p=h.categories,m=p.indexOf("");if(o[n]={categories:p,data:d,emptyIndex:m},void 0===c)continue;const f=a.Column.fromStrings("smiles",p.map(e=>i.getMonomer("PEPTIDE",e)?.smiles??"")),g=(a.DataFrame.fromColumns([f]),await r.chem.getSimilarities(f,u)),y=g?g.getRawData():null;for(let e=0;e<s;++e){const t=d[e];c!==ve._S&&t!==m?l[e]+=y[t]:c===ve._S&&t===m&&(l[e]+=1)}}for(let n=0;n<l.length;++n){let i=l[n]/t.length;for(let r=0;r<e.length;++r){const e=o[r];if(r>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&r<t.length){i=a.FLOAT_NULL;break}}l[n]=i}return a.Column.fromFloat32Array("Similarity",l)}(i,e,n);return o}(c,s,o):null;if(null===u)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return u.name=e.columns.getUnusedName(u.name),e.columns.add(u),u}(e,t,n,i,o);for(let e=0;e<s.length;e++)t.isNone(e)&&s.set(e,null,!1);return s}var Ai=n(294),xi=n(330);const Mi=OCL;var Ti=n(2582);class Ei{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null==e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null==e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var _i=n(6956);class Ii{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return null==t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(null==this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach((t,n)=>{const i=e[n-1];i===_i.m?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)})}}class Li{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Ni extends Li{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class Pi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){null==t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ri extends Pi{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class $i extends Ei{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Ni(n),this.bonds=new Ri(n),this.rGroups=new Ii(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Oi extends Li{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class ki extends Pi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Hi extends Ei{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Oi(n),this.bonds=new ki(n),this.rGroups=new Ii(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Bi{static getInstance(e,t){if($t.isMolfileV2K(e))return new $i(e,t);if($t.isMolfileV3K(e))return new Hi(e,t);throw new Error("Unsupported molfile version")}}class Fi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Bi.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Fi.molfileV2KToV3KCache.has(e))return Fi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Fi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map(e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,""))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Gi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Ti.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ve.b9[me.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Fi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new Ai.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?De.o.NUCLEOTIDE:De.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(r).take(n.atomCount).toArray(),bonds:R().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END BOND"].join("\n")}}class Di{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Vi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map(e=>null==e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Mi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,Se.AP)(e);return qr.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),s=`molfile(${e.name})`,l=o?o.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map(e=>{if(null==e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,xi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=Ai.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,Se.AP)(e);qr.logger.error(t,void 0,n),o=Ai.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Di(o),s=new Gi(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new Ai.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new Ai.vF(a.molfile,l)}}var Wi=n(2738);class ji{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[$e.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[$e.j.notationProvider]??null);const i=this.isFasta()?ve.b9[me.Hi.FASTA]:this.isSeparator()?ve.b9[me.Hi.SEPARATOR]:this.isHelm()?ve.b9[me.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ve.b9[me.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(me.gp.aligned)||!this.column.tags.has(me.gp.alphabet)||!this.column.tags.has(me.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===me.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(me.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(me.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(me.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${me.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null==r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=a.Func.find({tags:["notationRefiner"]});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[$e.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([me.Hi.FASTA,me.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(me.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(me.gp.aligned);null==t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(me.gp.aligned,t));let n=e.column.getTag(me.gp.alphabet);if(null==n&&(n=(0,Be.pc)(e.stats.freq,me.q7),e.column.setTag(me.gp.alphabet,n)),n===me.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(me.gp.alphabetSize,t.toString()),e.column.setTag(me.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===me.Hi.HELM){let t=e.column.getTag(me.gp.alphabet);if(null==t){const n=me.q7.map(e=>new Wi.a(e.name,e.alphabet,.9));t=(0,Be.p0)(e.stats.freq,n,e.defaultGapOriginal),e.column.setTag(me.gp.alphabet,t)}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(me.gp.separator)??void 0;if(this.notation===me.Hi.SEPARATOR&&null==e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(me.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(me.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===me.YI.RNA||this.alphabet===me.YI.DNA?De.o.NUCLEOTIDE:De.o.AA}get helmCompatible(){return this.column.getTag(me.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==me.Hi.HELM||this.alphabet==me.YI.UN){const e=this.column.getTag(me.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case me.YI.PT:return 20;case me.YI.DNA:case me.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===me.Hi.HELM||this.alphabet===me.YI.UN&&"true"===this.column.getTag(me.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!=this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ve.b9[me.Hi.FASTA]?ve._S:i??ve._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ve._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ve.b9[me.Hi.FASTA]?ve._S:o??ve._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new $e.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===me.Hi.HELM?n:this.notation===me.Hi.CUSTOM||this.notation===me.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(me.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===me.YI.DNA||e===me.YI.RNA||e===me.YI.PT}get stats(){if(null==this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null==this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null==this._posList){const e=this.column.getTag(me.gp.positionNames);this._posList=e?e.split(me.z1).map(e=>e.trim()):R().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===me.Hi.FASTA}isSeparator(){return this.notation===me.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===me.Hi.HELM}isCustom(){return this.notation===me.Hi.CUSTOM}isBiln(){return this.notation===me.Hi.BILN}isRna(){return this.alphabet===me.YI.RNA}isDna(){return this.alphabet===me.YI.DNA}isPeptide(){return this.alphabet===me.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(me.Hi.FASTA))return me.Hi.FASTA;if(this.units.toLowerCase().startsWith(me.Hi.SEPARATOR))return me.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(me.Hi.HELM))return me.Hi.HELM;if(this.units.toLowerCase().startsWith(me.Hi.CUSTOM))return me.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(me.Hi.BILN))return me.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===me.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${me.Hi.SEPARATOR}' requires separator value.`);l.setTag(me.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===me.Hi.HELM?"helm":"sequence");const c=o.getTag(me.gp.aligned);c&&l.setTag(me.gp.aligned,c);let u=o.getTag(me.gp.alphabet);u||this.notation!==me.Hi.HELM||e===me.Hi.HELM||(u=me.YI.UN),null!=u&&l.setTag(me.gp.alphabet,u);let h=o.getTag(me.gp.alphabetSize);null!=u&&h&&l.setTag(me.gp.alphabetSize,h);const d=o.getTag(me.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(me.gp.alphabetIsMultichar,d),e==me.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(me.gp.alphabetSize,h)),e===me.Hi.BILN&&(l.setTag(me.gp.separator,"-"),l.meta.units=me.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[me.Hi.FASTA,me.Hi.SEPARATOR,me.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!ji.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null==this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(me.Hi.FASTA))return null===this.column.getTag(me.gp.alphabet)||this.getAlphabetIsMultichar()?me.J9:Be.tm;if(this.units.toLowerCase().startsWith(me.Hi.SEPARATOR))return(0,me.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(me.Hi.HELM))return me.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return pe.Z.HAMMING;switch(this.alphabet){case me.YI.DNA:case me.YI.RNA:case me.YI.PT:}return pe.Z.LEVENSHTEIN}getDistanceFunction(){return pe.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(me.gp.isHelmCompatible))return"true"===this.column.getTag(me.gp.isHelmCompatible);const e=(await(0,we.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,me.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(me.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(me.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===me.Hi.FASTA}toSeparator(e){return e===me.Hi.SEPARATOR}toHelm(e){return e===me.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ve.b9[me.Hi.FASTA]:ve.b9[me.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,me.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(ge.EK,"$1")),n===ve.b9[me.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ve.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new Be.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(me.z1)},u=this.column.getTag(me.gp.positionNames);u&&i.setTag(me.gp.positionNames,c(u));const h=this.column.getTag(me.gp.positionLabels);return h&&i.setTag(me.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case me.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case me.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Ui(e,n,o.isHelm())};break;case me.Hi.HELM:{const e=o.alphabet===me.YI.DNA||o.alphabet===me.YI.RNA,t=o.getHelmWrappers();i=function(n){return qi(n,t,e)};break}case me.Hi.BILN:i=function(e){return zi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===me.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${me.Hi.SEPARATOR}'.`);const n=this;if(e===me.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===me.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===me.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===me.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[$e.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[$e.j.seqHandler]=new ji(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(ge.EK,"$1")),o===ve._S?r=ve.b9[me.Hi.FASTA]:o===ge.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Ui(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==me.Hi.HELM)return e;const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return qi(this.splitter(e),t,n)}convertToBiln(e){return this.notation==me.Hi.BILN?e:zi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(ge.EK,"$1"),r=r===ge.q7?null:r),n[e]=r||null}return new Be.Mu(n.filter(e=>!!e),ve.b9[me.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Ui(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(ge.EK,"$1")),o===ve._S?r=ve.b9[me.Hi.SEPARATOR]:o===ge.q7&&(r=""),i[t]=r}return i.join(t)}function qi(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,u=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ve._S?r=ve.b9[me.Hi.HELM]:(n&&(r=r.replace(ge.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),u[t-o]=r}l.push(`${i}${t+1}{${u.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ve._S?s=ve.b9[me.Hi.HELM]:(n&&(s=s.replace(ge.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function zi(e){const t=e=>e&&(e.includes("-")||e.includes("*")||e.includes("[R"));if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const n=e.graphInfo.disjointSeqStarts,i=new Array(e.length);for(let n=0;n<e.length;++n){const o=e.getCanonical(n);t(o)?i[n]=`[${o}]`:i[n]=o}for(let t=0;t<e.graphInfo.connections.length;t++){const o=e.graphInfo.connections[t],r=`${t+1}`,s=o.seqIndex1,a=o.seqIndex2,l=n[s]+o.monomerIndex1,c=n[a]+o.monomerIndex2,u=`${i[l]}(${r},${o.rGroup1})`,h=`${i[c]}(${r},${o.rGroup2})`;i[l]=u,i[c]=h}return n.map((t,o)=>{const r=o+1<n.length?n[o+1]:e.length;return i.slice(t,r).join("-")}).join(".")}{const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);t(o)?n[i]=`[${o}]`:n[i]=o}return n.join("-")}}class Yi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return ji.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,kt.b2)();return new Vi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return Ai.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return Ai.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return Ai.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new Ai.vF(e,o.monomers)}catch(e){const[t,n]=(0,Se.AP)(e);return qr.logger.error(t,void 0,n),Ai.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),s=e.dataFrame,l=(0,xi.qj)(s,e.name),c=await this.getHelmToMolfileConverter(o),u=e.toList(),h=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&p){const t=await p.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,h);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==me.Hi.FASTA)throw new Error(`The column of notation '${me.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=me.Hi.FASTA,ji.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${me.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${me.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=me.Hi.SEPARATOR,e.column.setTag(me.gp.separator,t),ji.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${me.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=me.Hi.HELM,ji.setTags(e)}}async function Ki(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![me.Hi.FASTA,me.Hi.SEPARATOR,me.Hi.HELM,me.Hi.BILN].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await Yr.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[$e.j.notationProvider]&&(i.temp[$e.j.notationProvider]=e.cell.column.temp[$e.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),s=(r.graphInfo?.connections?.length??0)>0,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Yr.toAtomicLevel(o,i,s||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){qr.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Zi="#333333",Xi="rgba(60, 177, 115, 0.1)",Ji="rgba(240, 240, 240, 0.5)",Qi="rgba(100, 100, 100, 0.3)";class eo{constructor(e=io.DEFAULT_TRACK_HEIGHT,t=io.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class to extends eo{constructor(e=new Map,t=io.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,io.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=De.o.NUCLEOTIDE;break;default:t=De.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,pi.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(s.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(s.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(s.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,r,s,a,u,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,u){const h=r+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const p=t+e*s,m=s-2;r+e===l&&(this.ctx.fillStyle=Xi,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=Ji,this.ctx.fillRect(p+1,c,m,u),this.drawLettersInColumn(h,p,m,c,u,d),this.drawColumnBorder(p,c,m,u)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class no extends eo{constructor(e,t=io.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,io.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,u=r,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=Xi,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=Ji,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=Qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Zi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const io={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},oo={BASE:io.DOTTED_CELL_HEIGHT+io.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+io.TITLE_HEIGHT+io.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+io.DEFAULT_TRACK_HEIGHT+io.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+io.DEFAULT_TRACK_HEIGHT+io.TRACK_GAP}};class ro{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||oo.BASE,sliderHeight:e.sliderHeight||io.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(io.DEFAULT_TRACK_HEIGHT)}),!(e<oo.WITH_TITLE()||e<oo.WITH_WEBLOGO()))if(e<oo.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-oo.WITH_WEBLOGO();t.setHeight(io.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>oo.WITH_BOTH()){const n=e-oo.WITH_BOTH();t.setHeight(io.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<oo.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<oo.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=oo.WITH_TITLE()?(io.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=oo.WITH_WEBLOGO();else{if("conservation"!==e)return;t=oo.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?oo.WITH_BOTH():oo.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=oo.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,io.TITLE_HEIGHT),this.ctx.fillStyle=Zi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+io.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof to&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0,l=this.config.headerHeight-io.SLIDER_HEIGHT-io.DOTTED_CELL_HEIGHT,c=l-io.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let f=c;for(const{id:e,track:t}of d){const i=f-t.getHeight();if(n>=i&&n<f){u=e,h=n-i;break}f=i-io.TRACK_GAP}let g=null;if(u){const e=this.tracks.get(u);e&&(g=e.getMonomerAt(t,h,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==u||this.previousHoverMonomer!==g)&&(this.previousHoverPosition=r,this.previousHoverTrack=u,this.previousHoverMonomer=g,u)){const e=this.tracks.get(u);e instanceof to&&(e.setHovered(r,g),window.requestAnimationFrame(()=>this.redraw()))}if((r!==this.currentHoverPosition||u!==this.currentHoverTrack||g!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=u,this.currentHoverMonomer=g,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(r,g);if(n)return void s.tooltip.show(n,e.clientX+16,e.clientY+16)}}u&&g||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=oo.WITH_TITLE();l&&io.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-io.SLIDER_HEIGHT,u=c-io.DOTTED_CELL_HEIGHT,h=u-io.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const f=this.getTrack("conservation");f&&f.isVisible()&&p.push({id:"conservation",track:f});let g=h;for(const{track:e}of p){const t=e.getHeight(),i=g-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),g=i-io.TRACK_GAP}if(this.drawDottedCells(0,u,n,io.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:io.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),u=t+io.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const h=e+n*s,d=s,p=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Zi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,io.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,io.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,io.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-io.SLIDER_HEIGHT;return t>n&&t<n+io.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-io.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+io.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=oo.WITH_TITLE()?io.TITLE_HEIGHT:0,a=this.config.headerHeight-io.SLIDER_HEIGHT-io.DOTTED_CELL_HEIGHT,l=a-io.TRACK_GAP;if(n>=a||n<s)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&h.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of h){const i=m-t.getHeight();if(n>=i&&n<m){c=e,u=n-i;break}m=i-io.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=oo.WITH_TITLE()&&t&&(so(e.left??0,n,i)||so(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-io.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:oo.BASE,WITH_TITLE:oo.WITH_TITLE(),WITH_WEBLOGO:oo.WITH_WEBLOGO(),WITH_BOTH:oo.WITH_BOTH()}}}function so(e,t,n){return e>=t&&e<=n}class ao{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){ao.conservationCache=new a.LruCache(100),ao.webLogoCache=new a.LruCache(100),ao.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return ao.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return ao.conservationCache.getOrCreate(i,()=>{const o=ao.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return ao.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/ao.CHUNK_SIZE)*ao.CHUNK_SIZE,s=Math.ceil(n/ao.CHUNK_SIZE)*ao.CHUNK_SIZE;for(let t=r;t<s;t+=ao.CHUNK_SIZE){const n=Math.min(t+ao.CHUNK_SIZE,i),r=ao.getChunkCacheKey(e.column,t,n),s=ao.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/ao.CHUNK_SIZE)*ao.CHUNK_SIZE,s=Math.ceil(n/ao.CHUNK_SIZE)*ao.CHUNK_SIZE;for(let t=r;t<s;t+=ao.CHUNK_SIZE){const n=Math.min(t+ao.CHUNK_SIZE,i),r=ao.getChunkCacheKey(e.column,t,n),s=ao.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class lo extends to{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=ao.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=ao.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class co extends no{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=ao.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=ao.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}const uo="__msa-scroller-initialized",ho="__msa-scroller-subscription";class po{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}constructor(e,t,n){this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=Be.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ve.Hi.HELM})(n)}createCellRendererBack(e,t){const n=qr.properties.maxMonomerLength||4,i=new mo(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class mo extends He.Jy{constructor(e,t,n,i){super(e,t,qr.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=He.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:Be.zS}})}}var fo,go;async function yo(){return await Yr.getMonomerLibHelper()}async function bo(){await Yr.initBio()}function vo(e){return Yr.sequenceTooltip(e)}async function wo(e){return await Yr.standardiseMonomerLibrary(e)}async function Co(e,t,n){await Yr.matchWithMonomerLibrary(e,t,n)}function So(){return Yr.getBioLib()}function Ao(e){return Yr.getSeqHandler(e)}function xo(e){return Yr.getRegionPanel(e)}async function Mo(e){return await Yr.libraryPanel(e)}function To(e){Yr.GetRegionEditor(e)}function Eo(e){Yr.SplitToMonomersEditor(e)}function _o(e){Yr.SequenceSpaceEditor(e)}function Io(e){Yr.SeqActivityCliffsEditor(e)}function Lo(){return Yr.customSequenceCellRenderer()}function No(){return Yr.fastaSequenceCellRenderer()}function Po(){return Yr.separatorSequenceCellRenderer()}function Ro(){return Yr.bilnSequenceCellRenderer()}function $o(e,t,n){return Yr.refineNotationProviderForBiln(e,t,n)}function Oo(e){return Yr.macroMolColumnPropertyPanel(e)}function ko(e){return Yr.compositionAnalysisWidget(e)}function Ho(){return Yr.macromoleculeDifferenceCellRenderer()}function Bo(e,t,n,i,o){return Yr.sequenceAlignment(e,t,n,i,o)}function Fo(){return Yr.webLogoViewer()}function Go(){return Yr.vdRegionsViewer()}function Do(e,t,n,i){return Yr.getRegion(e,t,n,i)}async function Vo(e,t,n,i,o){await Yr.getRegionTopMenu(e,t,n,i,o)}async function Wo(e,t,n,i,o,r,s,a,l){return await Yr.activityCliffs(e,t,n,i,o,r,s,a,l)}async function jo(e,t,n,i,o){return await Yr.macromoleculePreprocessingFunction(e,t,n,i,o)}async function Uo(e,t){return await Yr.helmPreprocessingFunction(e,t)}async function qo(e,t,n,i,o,r,s,a,l){return await Yr.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function zo(e,t){await Yr.moleculesToHelmTopMenu(e,t)}async function Yo(e,t,n,i){await Yr.toAtomicLevel(e,t,n,i)}async function Ko(e){await Yr.toAtomicLevelAction(e)}async function Zo(e){return await Yr.toAtomicLevelPanel(e)}async function Xo(e){return await Yr.sequence3dStructureWidget(e)}function Jo(){Yr.multipleSequenceAlignmentDialog()}async function Qo(e,t,n){return await Yr.alignSequences(e,t,n)}async function er(){return await Yr.compositionAnalysis()}function tr(e){return Yr.importFasta(e)}function nr(e){return Yr.importBam(e)}function ir(){Yr.convertDialog()}function or(e){Yr.convertColumnAction(e)}function rr(){return Yr.monomerCellRenderer()}async function sr(e){return await Yr.testDetectMacromolecule(e)}async function ar(e,t){return await Yr.splitToMonomersTopMenu(e,t)}function lr(e){return Yr.getHelmMonomers(e)}function cr(){return Yr.similaritySearchViewer()}function ur(){return Yr.similaritySearchTopMenu()}function hr(){return Yr.diversitySearchViewer()}function dr(){return Yr.diversitySearchTopMenu()}function pr(e){Yr.searchSubsequenceEditor(e)}function mr(e){Yr.SubsequenceSearchTopMenu(e)}async function fr(e,t,n){return await Yr.sequenceIdentityScoring(e,t,n)}async function gr(e,t,n){return await Yr.sequenceSimilarityScoring(e,t,n)}async function yr(){await Yr.manageMonomerLibraries()}async function br(){await Yr.manageLibrariesView()}async function vr(){await Yr.manageMonomersView()}async function wr(){return await Yr.manageMonomerLibrariesView()}async function Cr(e){await Yr.manageMonomerLibrariesViewTreeBrowser(e)}function Sr(){Yr.saveAsFasta()}function Ar(){return Yr.bioSubstructureFilter()}function xr(){return Yr.bioSubstructureFilterTest()}async function Mr(){await Yr.webLogoLargeApp()}async function Tr(){await Yr.webLogoAggApp()}async function Er(){await Yr.getRegionApp()}async function _r(){await Yr.getRegionHelmApp()}function Ir(){Yr.longSeqTableSeparator()}function Lr(){Yr.longSeqTableFasta()}function Nr(){Yr.longSeqTableHelm()}function Pr(e,t){Yr.addCopyMenu(e,t)}async function Rr(){await Yr.demoBioSimilarityDiversity()}async function $r(){await Yr.demoBioSequenceSpace()}async function Or(){await Yr.demoBioActivityCliffs()}async function kr(){await Yr.demoBioAtomicLevel()}async function Hr(e){await Yr.sdfToJsonLib(e)}async function Br(e,t){return await Yr.seq2atomic(e,t)}async function Fr(e,t){return await Yr.seqIdentity(e,t)}async function Gr(e,t,n){await Yr.detectMacromoleculeProbe(e,t,n)}async function Dr(){return await Yr.getSeqHelper()}async function Vr(e,t,n){return await Yr.getMolFromHelm(e,t,n)}!function(e){e.embed=async function(e){return await r.functions.call("Bio:Embed",{molecule:e})},e.molToHelmConverterPy=async function(e,t,n){return await r.functions.call("Bio:MolToHelmConverterPy",{moleculesDataframe:e,moleculesColumn:t,libraryJSON:n})},e.sequenceGenerator=async function(e,t,n,i,o,s,a,l,c,u,h,d,p,m,f,g,y){return await r.functions.call("Bio:SequenceGenerator",{clusters:e,num_sequences:t,alphabet_key:n,motif_length:i,max_variants_position:o,random_length:s,dispersion:a,activity_range:l,cliff_probability:c,cliff_strength:u,cliff_strength_dispersion:h,assay_noise_levels:d,assay_scales:p,disable_negatives:m,fasta_separator:f,helm_library_file:g,helm_connection_mode:y})}}(fo||(fo={})),function(e){e.test1=async function(){return await r.functions.call("Bio:Test1",{})},e.getMonomerLibHelper=async function(){return await r.functions.call("Bio:GetMonomerLibHelper",{})},e.initBio=async function(){return await r.functions.call("Bio:InitBio",{})},e.sequenceTooltip=async function(e){return await r.functions.call("Bio:SequenceTooltip",{col:e})},e.standardiseMonomerLibrary=async function(e){return await r.functions.call("Bio:StandardiseMonomerLibrary",{library:e})},e.matchWithMonomerLibrary=async function(e,t,n){return await r.functions.call("Bio:MatchWithMonomerLibrary",{table:e,molecules:t,polymerType:n})},e.getBioLib=async function(){return await r.functions.call("Bio:GetBioLib",{})},e.getSeqHandler=async function(e){return await r.functions.call("Bio:GetSeqHandler",{sequence:e})},e.getRegionPanel=async function(e){return await r.functions.call("Bio:GetRegionPanel",{seqCol:e})},e.libraryPanel=async function(e){return await r.functions.call("Bio:LibraryPanel",{seqColumn:e})},e.getRegionEditor=async function(e){return await r.functions.call("Bio:GetRegionEditor",{call:e})},e.splitToMonomersEditor=async function(e){return await r.functions.call("Bio:SplitToMonomersEditor",{call:e})},e.sequenceSpaceEditor=async function(e){return await r.functions.call("Bio:SequenceSpaceEditor",{call:e})},e.seqActivityCliffsEditor=async function(e){return await r.functions.call("Bio:SeqActivityCliffsEditor",{call:e})},e.customSequenceCellRenderer=async function(){return await r.functions.call("Bio:CustomSequenceCellRenderer",{})},e.fastaSequenceCellRenderer=async function(){return await r.functions.call("Bio:FastaSequenceCellRenderer",{})},e.separatorSequenceCellRenderer=async function(){return await r.functions.call("Bio:SeparatorSequenceCellRenderer",{})},e.bilnSequenceCellRenderer=async function(){return await r.functions.call("Bio:BilnSequenceCellRenderer",{})},e.refineNotationProviderForBiln=async function(e,t,n){return await r.functions.call("Bio:RefineNotationProviderForBiln",{col:e,stats:t,separator:n})},e.macroMolColumnPropertyPanel=async function(e){return await r.functions.call("Bio:MacroMolColumnPropertyPanel",{molColumn:e})},e.compositionAnalysisWidget=async function(e){return await r.functions.call("Bio:CompositionAnalysisWidget",{sequence:e})},e.macromoleculeDifferenceCellRenderer=async function(){return await r.functions.call("Bio:MacromoleculeDifferenceCellRenderer",{})},e.sequenceAlignment=async function(e,t,n,i,o){return await r.functions.call("Bio:SequenceAlignment",{alignType:e,alignTable:t,gap:n,seq1:i,seq2:o})},e.webLogoViewer=async function(){return await r.functions.call("Bio:WebLogoViewer",{})},e.vdRegionsViewer=async function(){return await r.functions.call("Bio:VdRegionsViewer",{})},e.getRegion=async function(e,t,n,i){return await r.functions.call("Bio:GetRegion",{sequence:e,start:t,end:n,name:i})},e.getRegionTopMenu=async function(e,t,n,i,o){return await r.functions.call("Bio:GetRegionTopMenu",{table:e,sequence:t,start:n,end:i,name:o})},e.activityCliffs=async function(e,t,n,i,o,s,a,l,c){return await r.functions.call("Bio:ActivityCliffs",{table:e,molecules:t,activities:n,similarity:i,methodName:o,similarityMetric:s,preprocessingFunction:a,options:l,demo:c})},e.macromoleculePreprocessingFunction=async function(e,t,n,i,o){return await r.functions.call("Bio:MacromoleculePreprocessingFunction",{col:e,metric:t,gapOpen:n,gapExtend:i,fingerprintType:o})},e.helmPreprocessingFunction=async function(e,t){return await r.functions.call("Bio:HelmPreprocessingFunction",{col:e,_metric:t})},e.sequenceSpaceTopMenu=async function(e,t,n,i,o,s,a,l,c){return await r.functions.call("Bio:SequenceSpaceTopMenu",{table:e,molecules:t,methodName:n,similarityMetric:i,plotEmbeddings:o,preprocessingFunction:s,options:a,clusterEmbeddings:l,isDemo:c})},e.moleculesToHelmTopMenu=async function(e,t){return await r.functions.call("Bio:MoleculesToHelmTopMenu",{table:e,molecules:t})},e.toAtomicLevel=async function(e,t,n,i){return await r.functions.call("Bio:ToAtomicLevel",{table:e,seqCol:t,nonlinear:n,highlight:i})},e.toAtomicLevelAction=async function(e){return await r.functions.call("Bio:ToAtomicLevelAction",{seqCol:e})},e.toAtomicLevelPanel=async function(e){return await r.functions.call("Bio:ToAtomicLevelPanel",{sequence:e})},e.sequence3dStructureWidget=async function(e){return await r.functions.call("Bio:Sequence3dStructureWidget",{sequence:e})},e.multipleSequenceAlignmentDialog=async function(){return await r.functions.call("Bio:MultipleSequenceAlignmentDialog",{})},e.alignSequences=async function(e,t,n){return await r.functions.call("Bio:AlignSequences",{sequenceCol:e,clustersCol:t,options:n})},e.compositionAnalysis=async function(){return await r.functions.call("Bio:CompositionAnalysis",{})},e.importFasta=async function(e){return await r.functions.call("Bio:ImportFasta",{fileContent:e})},e.importBam=async function(e){return await r.functions.call("Bio:ImportBam",{fileContent:e})},e.convertDialog=async function(){return await r.functions.call("Bio:ConvertDialog",{})},e.convertColumnAction=async function(e){return await r.functions.call("Bio:ConvertColumnAction",{col:e})},e.monomerCellRenderer=async function(){return await r.functions.call("Bio:MonomerCellRenderer",{})},e.testDetectMacromolecule=async function(e){return await r.functions.call("Bio:TestDetectMacromolecule",{path:e})},e.splitToMonomersTopMenu=async function(e,t){return await r.functions.call("Bio:SplitToMonomersTopMenu",{table:e,sequence:t})},e.getHelmMonomers=async function(e){return await r.functions.call("Bio:GetHelmMonomers",{sequence:e})},e.similaritySearchViewer=async function(){return await r.functions.call("Bio:SimilaritySearchViewer",{})},e.similaritySearchTopMenu=async function(){return await r.functions.call("Bio:SimilaritySearchTopMenu",{})},e.diversitySearchViewer=async function(){return await r.functions.call("Bio:DiversitySearchViewer",{})},e.diversitySearchTopMenu=async function(){return await r.functions.call("Bio:DiversitySearchTopMenu",{})},e.searchSubsequenceEditor=async function(e){return await r.functions.call("Bio:SearchSubsequenceEditor",{call:e})},e.subsequenceSearchTopMenu=async function(e){return await r.functions.call("Bio:SubsequenceSearchTopMenu",{macromolecules:e})},e.sequenceIdentityScoring=async function(e,t,n){return await r.functions.call("Bio:SequenceIdentityScoring",{table:e,macromolecule:t,reference:n})},e.sequenceSimilarityScoring=async function(e,t,n){return await r.functions.call("Bio:SequenceSimilarityScoring",{table:e,macromolecule:t,reference:n})},e.manageMonomerLibraries=async function(){return await r.functions.call("Bio:ManageMonomerLibraries",{})},e.manageLibrariesView=async function(){return await r.functions.call("Bio:ManageLibrariesView",{})},e.manageMonomersView=async function(){return await r.functions.call("Bio:ManageMonomersView",{})},e.manageMonomerLibrariesView=async function(){return await r.functions.call("Bio:ManageMonomerLibrariesView",{})},e.manageMonomerLibrariesViewTreeBrowser=async function(e){return await r.functions.call("Bio:ManageMonomerLibrariesViewTreeBrowser",{treeNode:e})},e.saveAsFasta=async function(){return await r.functions.call("Bio:SaveAsFasta",{})},e.bioSubstructureFilter=async function(){return await r.functions.call("Bio:BioSubstructureFilter",{})},e.bioSubstructureFilterTest=async function(){return await r.functions.call("Bio:BioSubstructureFilterTest",{})},e.webLogoLargeApp=async function(){return await r.functions.call("Bio:WebLogoLargeApp",{})},e.webLogoAggApp=async function(){return await r.functions.call("Bio:WebLogoAggApp",{})},e.getRegionApp=async function(){return await r.functions.call("Bio:GetRegionApp",{})},e.getRegionHelmApp=async function(){return await r.functions.call("Bio:GetRegionHelmApp",{})},e.longSeqTableSeparator=async function(){return await r.functions.call("Bio:LongSeqTableSeparator",{})},e.longSeqTableFasta=async function(){return await r.functions.call("Bio:LongSeqTableFasta",{})},e.longSeqTableHelm=async function(){return await r.functions.call("Bio:LongSeqTableHelm",{})},e.addCopyMenu=async function(e,t){return await r.functions.call("Bio:AddCopyMenu",{cell:e,menu:t})},e.demoBioSimilarityDiversity=async function(){return await r.functions.call("Bio:DemoBioSimilarityDiversity",{})},e.demoBioSequenceSpace=async function(){return await r.functions.call("Bio:DemoBioSequenceSpace",{})},e.demoBioActivityCliffs=async function(){return await r.functions.call("Bio:DemoBioActivityCliffs",{})},e.demoBioAtomicLevel=async function(){return await r.functions.call("Bio:DemoBioAtomicLevel",{})},e.sdfToJsonLib=async function(e){return await r.functions.call("Bio:SdfToJsonLib",{table:e})},e.seq2atomic=async function(e,t){return await r.functions.call("Bio:Seq2atomic",{seq:e,nonlinear:t})},e.seqIdentity=async function(e,t){return await r.functions.call("Bio:SeqIdentity",{seq:e,ref:t})},e.detectMacromoleculeProbe=async function(e,t,n){return await r.functions.call("Bio:DetectMacromoleculeProbe",{file:e,colName:t,probeCount:n})},e.getSeqHelper=async function(){return await r.functions.call("Bio:GetSeqHelper",{})},e.getMolFromHelm=async function(e,t,n){return await r.functions.call("Bio:GetMolFromHelm",{df:e,helmCol:t,chiralityEngine:n})}}(go||(go={}));var Wr=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},jr=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Ur=function(e,t){return function(n,i){t(n,i,e)}};const qr=new di;let zr=null;r.decorators||(r.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{r.decorators[e]||(r.decorators[e]=function(e){return function(e,t,n){}})});class Yr{static async getMonomerLibHelper(){return await Hn.getInstance()}static async initBio(){null==zr&&(zr=async function(){const e="Bio: _package.initBio()";qr.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Re.j)(),i=await qr.getProperties(),o=new hi(i);qr.properties=o;const s=await Hn.getInstance(),l=await(0,Pe.u)();l.explicit&&(l.explicit=[],await(0,Pe.E)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),h=s.getMonomerSets(),d=window.performance.now();qr.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new Yi(s,n);qr.completeInit(p,c,h,n),qr.logger.debug(`${e}, end`),function(){const e=t=>{setTimeout(()=>{if(t.isDetached)return;const n=t.dataFrame;if(!n)return;const i=n.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);t.temp[ho]?.unsubscribe(),t.temp[ho]=a.debounce(u.merge(n.onColumnsAdded,n.onSemanticTypeDetected),200).subscribe(()=>e(t)),t.sub(t.temp[ho]);for(const e of i){const i=t.col(e.name);if(!i)continue;if(i.temp[uo])continue;i.temp[uo]=!0;let o=null;try{o=qr.seqHelper.getSeqHandler(e)}catch(t){console.warn(`Failed to get SeqHandler for column ${e.name}`);continue}if(!o)continue;if(o.isHelm()||o.alphabet===me.YI.UN)continue;let s=!!t.tableView&&Array.from(t.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);const l=(e,t)=>Number.isNaN(e)||null==e?t:e,c=()=>l(Math.max(Number.parseInt(e.getTag(me.gp.positionShift)??"0"),0),0)+1,h=()=>l(Number.parseInt(e.getTag(me.gp.selectedPosition)??"-2"),-2),d=()=>He.Jy.getFontSettings(e).fontWidth;let p=0,m=0;const f=e.categories;for(let e=0;e<f.length;e++){const t=f[e];t&&t.length>m&&(m=t.length,p=e)}const g=f[p],y=o.splitter(g),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=e.length>1e5||b<50?v.WITH_TITLE:e.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,S=null;const A=a.debounce(u.merge(n.onFilterChanged,n.onDataChanged.pipe((0,k.filter)(t=>t?.args?.column===e))),100).subscribe(()=>{ao.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),S&&(S.resetViewportTracking(),S.forceUpdate()),setTimeout(()=>{t.isDetached||t.invalidate()},50)});t.sub(A);const x=r=>{const l=[],u=new co(o,b,45,"default","Conservation");S=u,l.push({id:"conservation",track:u,priority:1});const p=new lo(o,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(o.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new ro({canvas:t.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(n,i)=>{setTimeout(()=>{const o=c(),r=h();if(o!==i.start&&e.setTag(me.gp.positionShift,(i.start-1).toString()),r!==n&&(e.setTag(me.gp.selectedPosition,n.toString()),n>=0&&!s&&t.tableView&&R()(t.dataFrame?.columns.numerical).find(e=>!0))){s=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:e=>{t.isDetached||e<v.WITH_TITLE||setTimeout(()=>t.props.colHeaderHeight=e)}},i);m.setupTooltipHandling(),l.forEach(({id:e,track:t})=>{m.addTrack(e,t)}),m.setSelectionData(n,e,o),b>50&&(t.props.colHeaderHeight=w,setTimeout(()=>{t.isDetached||(i.width=400)},300)),t.sub(t.onCellRender.subscribe(t=>{const n=t.cell;if(!n||!n.isColHeader||n?.gridColumn?.name!==i?.name)return;const o=t.bounds;if(!o)return;m.headerHeight=o.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(o.x,o.y,o.width,o.height,h(),s,t,e.name)}))};(0,we.pj)().then(e=>{const t=e.getMonomerLib();x(t)}).catch(e=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}},1e3)},t=(r.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)}),r.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await zr}static sequenceTooltip(e){const t=new gi(e,qr.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();r.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await en(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const o=n.duplicateMonomers?.[i]??{},r=a.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!r)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const s=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),l=await en(s),c=l.filter(e=>!!e.smiles).reduce((e,t)=>(e[t.smiles]={symbol:t.symbol,smiles:t.smiles,original:t.smiles,source:t.lib?.source},e),{}),u=l.map((e,t)=>({symbol:e.symbol,smiles:hn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:s[t]?.lib?.source})).filter(e=>!!e?.smiles&&!e.smiles.includes("[*:")),h=a.Column.fromList(a.COLUMN_TYPE.STRING,"MonomerSmiles",u.map(e=>e.smiles));h.semType=a.SEMTYPE.MOLECULE;const d=await r.apply({molecule:h,targetNotation:a.chem.Notation.Smiles});if(!d||d.length!==h.length)throw new Error("Error canonicalizing monomer smiles");d.toList().forEach((e,t)=>u[t].smiles=e);const p=u.reduce((e,t)=>(e[t.smiles]=t,e),{}),m=e.col(t).toList().map(e=>{if(!e)return e;try{const t=e.includes("\n");return cn([],t?void 0:e,t?e:void 0)}catch(t){return e}}),f=a.Column.fromList(a.COLUMN_TYPE.STRING,"MoleculesOriginalCorrected",m);f.semType=a.SEMTYPE.MOLECULE,a.DataFrame.fromColumns([f]);const g=await r.apply({molecule:f,targetNotation:a.chem.Notation.Smiles});if(!g||g.length!==f.length)throw new Error("Error canonicalizing molecules");const y=g.toList(),b=e.clone(),v=b.columns.addNewString(b.columns.getUnusedName("Matched monomer smiles"));v.semType=a.SEMTYPE.MOLECULE;const w=b.columns.addNewString(b.columns.getUnusedName("Matched monomer symbol"));w.semType="Monomer";const C=b.columns.addNewString(b.columns.getUnusedName("Matched monomer source"));b.columns.setOrder([t,w.name,v.name,C.name]);for(let e=0;e<y.length;e++){const t=y[e];if(!t)continue;const n=p[t]??c[t];if(n){const t=n.symbol,i=(o[t]?.length??0)>0?o[t].map(e=>e?.lib?.source).filter(e=>!!e).join(", "):n.source??"",r=n.original??n.smiles;v.set(e,r,!1),w.set(e,t,!1),C.set(e,i,!1)}}return b}(e,t.name,qr.monomerLib,n);r.shell.addTableView(i)}static getBioLib(){return qr.monomerLib}static getSeqHandler(e){return qr.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:qr.name,name:t});if(1!==n.length)throw new Error(`Package '${qr.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new wi(i,qr.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=s.label("Manage monomer libraries");return Fn()(e).addClass("d4-link-action"),e.onclick=async()=>await Un(),new a.Widget(e)}()}static GetRegionEditor(e){try{new wi(e,qr.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(`Get region editor error: ${t}`),qr.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ri;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new xe({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new Ye}static fastaSequenceCellRenderer(){return new Ye}static separatorSequenceCellRenderer(){return new Ye}static bilnSequenceCellRenderer(){return new Ye}static refineNotationProviderForBiln(e,t,n){return"-"===n&&(!(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))&&!Object.keys(t.freq).some(e=>e.includes("[")||e.includes("]")))&&(e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=me.Hi.BILN,e.temp[$e.j.notationProvider]=new po(n,qr.seqHelper,e),!0))}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===a.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=qr.properties?qr.properties.maxMonomerLength:4;if(ke.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(ke.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=qr.properties?qr.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Ve.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),u=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),h=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==me.Hi.HELM&&(d=s.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,u,c,h];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[me.gp.alphabet],r=o===me.YI.DNA||o===me.YI.RNA?De.o.NUCLEOTIDE:De.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u),d={};R().count(0).take(h.length).filter(e=>!h.isGap(e)).forEach(e=>{let t=h.getCanonical(e);r===De.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&h.graphInfo?.polymerTypes){const n=h.graphInfo.polymerTypes[e];d[t]=(0,Be.MD)(n)}});const p=(0,pi.F)(l,r,t,Object.keys(d).length?d:void 0);return Array.from(p.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(p),new a.Widget(i)}(e,qr.monomerLib,qr.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ze}static sequenceAlignment(e,t,n,i,o){const r=new dt(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new ot.oP}static vdRegionsViewer(){return new ct}static getRegion(e,t,n,i){return yi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const s=yi(t,n??null,i??null,o??null);t.dataFrame.columns.add(s),await r.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,u,h,d,p){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);if(!(0,ti.V)(t,"Activity Cliffs"))return;const m=_e(e),f={units:t.meta.units,aligned:t.getTag(me.gp.aligned),separator:t.getTag(me.gp.separator),alphabet:t.getTag(me.gp.alphabet)},g=u,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,g,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,h,ft,gt,wt,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),S=await new Promise((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,Se.AP)(e);throw qr.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return S?.props?.xColumnName&&S?.props?.yColumnName&&e.col(S.props.xColumnName)&&e.col(S.props.yColumnName)&&(e.col(S.props.xColumnName).set(0,e.col(S.props.xColumnName).get(0)),e.col(S.props.yColumnName).set(0,e.col(S.props.yColumnName).get(0))),S}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:s}=await pt(e,t,o,n,i);return{entries:r,options:s}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,mt.BQ)(e,qr.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=j.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,s,c,u,h){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);const d=r.shell.tv.dataFrame==e?r.shell.tv:void 0;return(0,ti.V)(t,"Sequence Space")?(s||(s=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await Le(e,[t],n,[i],[1],[s],"MANHATTAN",o,u??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async moleculesToHelmTopMenu(e,t){const n=qr.monomerLib,i=JSON.stringify(n.toJSON());await fo.molToHelmConverterPy(e,t,i);const o=e.columns.toList().find(e=>e.name.toLowerCase().includes("regenerated sequence")&&e.semType!==a.SEMTYPE.MACROMOLECULE);o&&(o.meta.units=me.Hi.HELM,o.semType=a.SEMTYPE.MACROMOLECULE,o.setTag("cell.renderer","helm"))}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await zr;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??qr.monomerLib,r=qr.seqHelper,s=qr.rdKitModule;await(0,Ci.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Ki(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(s.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(t.mol,e,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){qr.logger.error(e)}return a.Widget.fromRoot(s.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Ki(e);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=Mi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=s.div([t],{style:{aspectRatio:"1"}})}catch(e){n=s.divText("Couldn't get 3D structure")}}catch(e){n=s.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,ii.D)({},qr.seqHelper).catch(e=>{const[t,n]=(0,Se.AP)(e);if(e instanceof ni.Ap)return r.shell.warning(e.element),void qr.logger.warning(t);r.shell.error(t),qr.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,ii.D)({col:e,clustersCol:t,...n},qr.seqHelper)}static async compositionAnalysis(){const e=r.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(qr.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,ti.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>qr.seqHelper.getSeqHandler(e).isMsa()),o=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}static importFasta(e){return new fe.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Oe.me)()[0];(0,Et.C)(e,qr.seqHelper)}static convertColumnAction(e){(0,Et.C)(e,qr.seqHelper)}static monomerCellRenderer(){return new ci}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const o=[];for(const s of n)try{const t=await r.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${e}`,s}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,et.cb)(10),!(0,ti.V)(t,"Sequence space"))return e;const n=ye(t,qr.seqHelper);n.name="splitToMonomers";const i=t.dataFrame;for(const e of n.columns)e.semType=Ue.uF.MONOMER,e.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const o=/(\d+)(?: \((\d+)\))?/,s=e=>{o.lastIndex=0;const t=e.match(o);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const o=n.columns.byIndex(e);o.semType=Ue.uF.MONOMER,o.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const r=100;let a=0;for(;i.columns.byName(o.name)&&a<r;)o.name=s(o.name),a++;i.columns.add(o)}await r.data.detectSemanticTypes(i);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return i}(e,t)}static getHelmMonomers(e){return qr.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new xt(qr.seqHelper)}static similaritySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new Mt(qr.seqHelper)}static diversitySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Oe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new mt.a7(t,qr.seqHelper)}static SubsequenceSearchTopMenu(e){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),r.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=qr.seqHelper;return Si(e,t,n,be.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=qr.seqHelper;return Si(e,t,n,be.SIMILARITY,i)}static async manageMonomerLibraries(){Un()}static async manageLibrariesView(){await qn()}static async manageMonomersView(){const e=await nn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await qn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await Hn.getInstance()).getAvaliableLibraryNames()).forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await nn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,_t.TE)()}static bioSubstructureFilter(){return new It._i(qr.seqHelper,qr.logger)}static bioSubstructureFilterTest(){return new It._i(qr.seqHelper,qr.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new oi(e,"webLogoLargeApp"),n=await qr.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new oi(e,"webLogoAggApp"),n=await qr.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new vi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await qr.files.readCsv("samples/HELM_empty_vals.csv"),n=new vi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,Ne.dW)());r.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(qr.seqHelper,me.Hi.FASTA)]);r.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(qr.seqHelper,me.Hi.HELM)]);r.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(me.Hi).filter(e=>e!==me.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,o=e.rowIndex,s=n.getSeqHandler(i),a=t===me.Hi.SEPARATOR?qr.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${t}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,qr.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await qr.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=r.shell.addTableView(e);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Oe.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await r.functions.eval("Bio:SeqSpaceDemo"),t=await r.dapi.projects.find(e.id);await t.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await qr.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=r.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Yr.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,pe.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),Fn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===a.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(t),qr.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await qr.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const t=r.shell.addTableView(e),n=e.col("HELM");await Yr.toAtomicLevel(e,n,!0,!1),(0,Oe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Oe.Kd)(t.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#convert-to-atomic-level")}()}static async sdfToJsonLib(e){const t=function(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(ge.Ec).forEach(t=>{if("symbol"===t){const o=e.get(ge.Ec[t],n);i[t]="."===o?e.get(ge.yw,n):o}else if("rgroups"===t){const o=e.get(ge.Ec[t],n).split("\n"),r=[];o.forEach(e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,r.push(t)}),i[t]=r}else ge.Ec[t]&&(i[t]=e.get(ge.Ec[t],n))}),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await Yr.getMonomerLibHelper()).getMonomerLib(),l=qr.seqHelper,c=await(0,Re.j)(),u=(await(0,Ci.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return u??void 0}catch(e){const[t,n]=(0,Se.AP)(e);throw qr.logger.error(t,void 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for(f=e.scalingRatio,a=0;a<E;a+=t)for(l=0;l<a;l+=t)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,f=e.scalingRatio,s=0;s<E;s+=t)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(e.outboundAttractionDistribution?m:1),u=0;u<_;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===I)for(s=0;s<E;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+A)/(1+Math.sqrt(S)),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,T=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=T);else for(s=0;s<E;s+=t)1!==n[s+9]&&(S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+A)/(1+Math.sqrt(S)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(S)))),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,T=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=T);return{}}},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.x).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA|CHEM|BLOB)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA|CHEM|BLOB)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=e.indexOf("}$"),n=e.substring(0,t+1),i=e.indexOf("$",t+2),r=e.substring(t+2,i),a=n.split("}|");for(let e=0;e<a.length-1;e++)a[e]=a[e]+"}";this.simplePolymers=a.map(e=>new s(e)),this.connectionList=new o(r),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>t-e).find(t=>e>=t);if(null==n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const i=n(8727),o=n(208),r=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),u=n(9029),h=n(2023),d=n(6939),p=n(4227),m=n(8708);function f({gen:e,validateName:t,schema:n,schemaEnv:i,opts:o},r){o.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,i.$async,()=>{e.code(u._`"use strict"; ${g(n,o)}`),function(e,t){e.if(h.default.valCxt,()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)},()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)})}(e,o),e.code(r)}):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(o)}`,i.$async,()=>e.code(g(n,o)).code(r))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:i,self:o}=e;t.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,o.RULES)&&o.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return S(e,[],!1,t);const n=(0,o.getSchemaTypes)(e.schema);S(e,n,!(0,o.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:i,opts:o}){const r=n.$comment;if(!0===o.$comment)e.code(u._`${h.default.self}.logger.log(${r})`);else if("function"==typeof o.$comment){const n=u.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function S(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:m}=e,{RULES:f}=m;function g(p){(0,r.shouldUseGroup)(a,p)&&(p.type?(o.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),A(e,p),1===t.length&&t[0]===p.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):A(e,p),c||o.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach(t=>{x(e.dataTypes,t)||M(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)}),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&M(e,"use 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${o}(${h.default.vErrors})`)):(t.assign(u._`${i}.errors`,h.default.vErrors),r.unevaluated&&function({gen:e,evaluated:t,props:n,items:i}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),i instanceof u.Name&&e.assign(u._`${t}.items`,i)}(e),t.return(u._`${h.default.errors} === 0`))}(e)})}(e):f(e,()=>(0,i.topBoolOrEmptySchema)(e))};class T{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",L(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in 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r={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,o.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...e};Object.entries(s).forEach(([e,n])=>t[e.charCodeAt(0)]=n);const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,r)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,h=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let u=1;u<r.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<e.length+1;d++){const p=a[c][d-1]+o[t[e.charCodeAt(d-1)]][t[r.charCodeAt(u-1)]],m=a[c][d]-(s[d]||1===u||u===r.length?i:n),g=a[h][d-1]-(l[d-1]||1===d||d===e.length?i:n);a[h][d]=Math.max(p,g,m),a[h][d]===p?(s[d]=!1,l[d]=!1):a[h][d]===g?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=h,h=(h+1)%2}const u=Math.min(e.length,r.length);return(u-a[c][e.length])/u}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},6869:(e,t,n)=>{"use strict";var i;n.d(t,{o:()=>i}),function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>h,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(e=1e4){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function h(e,t=s.Hi.SEPARATOR,n=s.YI.PT,o=(t===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,g=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);g.semType=i.SEMTYPE.MACROMOLECULE,g.meta.units=t,g.setTag(s.gp.alphabet,n),t==s.Hi.SEPARATOR&&g.setTag(s.gp.separator,o);const f=e.getSeqHandler(g);for(let e=0;e<u;e++){const n=r().count(0).take(d).map(e=>p[Math.floor(Math.random()*m)]).toArray(),i=f.joiner(new a.Mu(n,l.b9[t]));g.set(e,i)}return g}},6882:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(4971),u=n(9192),d=n(3856),p=n(673),m=n(3599),g=n(5553),f=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,r){if(super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe(()=>{this._onRendered.next()})),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe(()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(t=>t.args.source===this.tableCol&&e.includes(t.args.key))),200).subscribe(e=>{this.reset()})),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift)),200).subscribe(e=>{this.reset()}))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,r){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const h=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,g=Math.max(0,Math.floor(m/s)),f=[];let y=0;for(let e=0;e<g&&y<h.length;e++){const t=[];for(let e=0;e<p&&y<h.length;e++){const n=h[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}f.push({lineIdx:e,elements:t})}return{lineLayouts:f,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,h.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe(()=>{this.reset()})),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=this.padding;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(t/i)+o,s=n.splitter(e),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=s.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,r=n.getSplitted(e),s=Math.min(o,r.length);let a=this._monomerLengthList[e];if(null===a||a.length!=s-t){a=this._monomerLengthList[e]=new Array(r.length);let i=0;for(let e=t;e<s;++e){const o=r.getOriginal(e),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[e-t]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let e=n;e<i;e++){if(this._processedRows.get(e)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,s),i=Math.min(s,n.length);i-r>t.length&&t.push(...new Array(i-r-t.length).fill(o));let a=0;for(let e=r;e<i;++e){const i=n.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(t[e-r]=Math.max(t[e-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(e,!0)}return t}getPosition(e,t,n,i){const[o,r]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:function(e,t,n){if((n??0)>0&&t<(e[0]??0)+n)return-1;t-=n??0;let i,o=100,r=0,s=e.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),e[i]<=t&&t<e[i+1])return i;if(t<e[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t,i)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}get positionShift(){const e=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(e)?0:Math.max(e,0)}render(e,t,n,i,r,a,c){const h=a.grid?.dart&&a.grid?.canvas===e.canvas;if(!this.seqHelper)return;const m=this.tableCol,g=this.positionShift;e.save();try{const c=this.seqHelper.getSeqHandler(m);let u=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));u=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const e=m.temp[".mm.cellRenderer.maxMonomerLength"],t="number"==typeof e?e:parseInt(e);u=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=u){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(u),this.setSeparatorWidth(c.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const f=a.cell.rowIndex,b=a.cell.value;h&&(i=v(a.grid,e,t,i,window.devicePixelRatio)),e.beginPath(),e.rect(t,n,i,r),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),S=m.getTag(l.gp.separator)??"",A=h?c.getSplitted(f):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const E=m.temp["reference-sequence"],M=this.tableCol.temp["current-word"],T=(()=>{const e=(0,c.splitter)(null!=E&&""!==E?E:M??"");return s().count(0).take(e.length).slice(g).map(t=>e.getCanonical(t)).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const s=[],l=this.calculateMultiLineLayoutDynamic(e,i,r,A,g,u);let h=n+this.padding;1===l.lineLayouts.length&&(h=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=h+i.lineIdx*l.lineHeight;for(const h of i.elements){const u=t+h.x,p=h,f=p.posIdx,b=A.getCanonical(f);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&T.length>0){const e=f-g;e>=0&&e<T.length&&b===T[e]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:f-g,bounds:new o.Rect(h.x,r-n,h.width,l.lineHeight),sequencePosition:f}),(0,d.oZ)(e,p.om,u,r,h.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:f})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(g)?e.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);h||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(A.length,Math.ceil(i/s)+g);for(let s=g;s<l;++s){const l=s<A.length?A.getOriginal(s):c.defaultGapOriginal,h=s<A.length?A.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,h));const m=s===A.length-1,f={color:p,pivot:0,left:!0,transparencyRate:0,separator:(A?.graphInfo?.disjointSeqStarts?.indexOf(s+1)??0)>0?"|":S,last:m,drawStyle:x,maxWord:o,wordIdx:s-g,gridCell:a,referenceSequence:T,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-g};(0,d.oZ)(e,l,t+this.padding+this._leftThreeDotsPadding,n,i,r,f)}if(this.shouldRenderShiftedThreeDots(g)){const 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r={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,o.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...e};Object.entries(s).forEach(([e,n])=>t[e.charCodeAt(0)]=n);const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,r)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let h=1;h<r.length+1;h++){a[u][0]=-i-(h-1)*i;for(let d=1;d<e.length+1;d++){const p=a[c][d-1]+o[t[e.charCodeAt(d-1)]][t[r.charCodeAt(h-1)]],m=a[c][d]-(s[d]||1===h||h===r.length?i:n),f=a[u][d-1]-(l[d-1]||1===d||d===e.length?i:n);a[u][d]=Math.max(p,f,m),a[u][d]===p?(s[d]=!1,l[d]=!1):a[u][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.min(e.length,r.length);return(h-a[c][e.length])/h}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},6869:(e,t,n)=>{"use strict";var i;n.d(t,{o:()=>i}),function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>u,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(e=1e4){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function u(e,t=s.Hi.SEPARATOR,n=s.YI.PT,o=(t===s.Hi.SEPARATOR?"-":void 0),c=void 0,u="seq",h=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,u,h);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=t,f.setTag(s.gp.alphabet,n),t==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,o);const g=e.getSeqHandler(f);for(let e=0;e<h;e++){const n=r().count(0).take(d).map(e=>p[Math.floor(Math.random()*m)]).toArray(),i=g.joiner(new a.Mu(n,l.b9[t]));f.set(e,i)}return f}},6882:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),u=n(4971),h=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,r){if(super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe(()=>{this._onRendered.next()})),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe(()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter(t=>t.args.source===this.tableCol&&e.includes(t.args.key))),200).subscribe(e=>{this.reset()})),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter(e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift)),200).subscribe(e=>{this.reset()}))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,r){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const u=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,r);u.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===u.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,f=Math.max(0,Math.floor(m/s)),g=[];let y=0;for(let e=0;e<f&&y<u.length;e++){const t=[];for(let e=0;e<p&&y<u.length;e++){const n=u[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}g.push({lineIdx:e,elements:t})}return{lineLayouts:g,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,u.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe(()=>{this.reset()})),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=this.padding;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(t/i)+o,s=n.splitter(e),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=s.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,r=n.getSplitted(e),s=Math.min(o,r.length);let a=this._monomerLengthList[e];if(null===a||a.length!=s-t){a=this._monomerLengthList[e]=new Array(r.length);let i=0;for(let e=t;e<s;++e){const o=r.getOriginal(e),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[e-t]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let e=n;e<i;e++){if(this._processedRows.get(e)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,s),i=Math.min(s,n.length);i-r>t.length&&t.push(...new Array(i-r-t.length).fill(o));let a=0;for(let e=r;e<i;++e){const i=n.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(t[e-r]=Math.max(t[e-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(e,!0)}return t}getPosition(e,t,n,i){const[o,r]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:function(e,t,n){if((n??0)>0&&t<(e[0]??0)+n)return-1;t-=n??0;let i,o=100,r=0,s=e.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),e[i]<=t&&t<e[i+1])return i;if(t<e[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t,i)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}get positionShift(){const e=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(e)?0:Math.max(e,0)}render(e,t,n,i,r,a,c){const u=a.grid?.dart&&a.grid?.canvas===e.canvas;if(!this.seqHelper)return;const m=this.tableCol,f=this.positionShift;e.save();try{const c=this.seqHelper.getSeqHandler(m);let h=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));h=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const e=m.temp[".mm.cellRenderer.maxMonomerLength"],t="number"==typeof e?e:parseInt(e);h=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=h){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(h),this.setSeparatorWidth(c.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const g=a.cell.rowIndex,b=a.cell.value;u&&(i=v(a.grid,e,t,i,window.devicePixelRatio)),e.beginPath(),e.rect(t,n,i,r),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),S=m.getTag(l.gp.separator)??"",A=u?c.getSplitted(g):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const M=m.temp["reference-sequence"],T=this.tableCol.temp["current-word"],E=(()=>{const e=(0,c.splitter)(null!=M&&""!==M?M:T??"");return s().count(0).take(e.length).slice(f).map(t=>e.getCanonical(t)).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const s=[],l=this.calculateMultiLineLayoutDynamic(e,i,r,A,f,h);let u=n+this.padding;1===l.lineLayouts.length&&(u=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=u+i.lineIdx*l.lineHeight;for(const u of i.elements){const h=t+u.x,p=u,g=p.posIdx,b=A.getCanonical(g);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&E.length>0){const e=g-f;e>=0&&e<E.length&&b===E[e]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:g-f,bounds:new o.Rect(u.x,r-n,u.width,l.lineHeight),sequencePosition:g}),(0,d.oZ)(e,p.om,h,r,u.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:g})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(f)?e.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);u||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(A.length,Math.ceil(i/s)+f);for(let s=f;s<l;++s){const l=s<A.length?A.getOriginal(s):c.defaultGapOriginal,u=s<A.length?A.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,u));const m=s===A.length-1,g={color:p,pivot:0,left:!0,transparencyRate:0,separator:(A?.graphInfo?.disjointSeqStarts?.indexOf(s+1)??0)>0?"|":S,last:m,drawStyle:x,maxWord:o,wordIdx:s-f,gridCell:a,referenceSequence:E,maxLengthOfMonomer:h,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-f};(0,d.oZ)(e,l,t+this.padding+this._leftThreeDotsPadding,n,i,r,g)}if(this.shouldRenderShiftedThreeDots(f)){const 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