@datagrok/bio 2.23.0 → 2.23.2

package/dist/package.js

@@ -1,8 +1,8 @@
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this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map(e=>e.value))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,s,a,l,c){const h=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1);for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*l*s,u,a*l,n),u+=n}}render(e,t,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;r&&(p=r.getMonomerTextColor(o,a)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,h.top,h.width,h.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(c);e.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),e.fillText(c,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find(([n,i])=>i.bounds.contains(e,t));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,S.F)(Object.assign({},...Object.entries(this._freqs).map(([e,t])=>({[e]:t.rowCount}))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(w||(w={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(C||(C={}));const M=d.Fo;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const T=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,M.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],t=Object.values(r.AGG).filter(t=>!e.includes(t));this.valueColumnName=this.string(C.valueColumnName,M.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(E.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new h.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(u.gp.positionNames),t=this.seqCol.getTag(u.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(u.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(u.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new x(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const h=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],u=(l-s)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let e=o;e<=s;e++)this.positions[e].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,async()=>{await this.renderInt(e)})):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(E.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.BitSet.create(this.dataFrame.selection.length,e=>function(e,t,n,i,o,r){const s=t.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i));this.dataFrame.selection.init(t=>e.get(t))}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` 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type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=i,this.emit("edgeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,i),this.emit("edgeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(t,": provided updater is not a function."));return o.attributes=i(o.attributes),this.emit("edgeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],X=N,J=H,Q=function(){var e=arguments,t=null,n=-1;return new X(function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i})},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var o=!1;for(var r in t)if(r!==i){var s=t[r];if(o=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&o)return s.key}}function ne(e,t,n,i){var o,r,s,a=!1;for(var l in t)if(l!==i){o=t[l];do{if(r=o.source,s=o.target,a=n(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected),e&&a)return o.key;o=o.next}while(void 0!==o)}}function ie(e,t){var n,i=Object.keys(e),o=i.length,r=0;return new N(function(){do{if(n)n=n.next;else{if(r>=o)return{done:!0};var s=i[r++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}})}function oe(e,t,n,i){var o=t[n];if(o){var r=o.source,s=o.target;return i(o.key,o.attributes,r.key,s.key,r.attributes,s.attributes,o.undirected)&&e?o.key:void 0}}function re(e,t,n,i){var o=t[n];if(o){var r=!1;do{if(r=i(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&r)return o.key;o=o.next}while(void 0!==o)}}function se(e,t){var n=e[t];return void 0!==n.next?new N(function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}}):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var h=r,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,r.undirected),e&&l)return u}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var he=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ue(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var h=o(c.key,c.attributes);if(e&&h)return c.key}}}function pe(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new ue;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function me(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),e&&u))return null}}function fe(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ue.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},ue.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Se={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),h=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new j("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);e._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,u.key=o,e.emit("edgeAdded",u),o}function Me(e,t,n,i,o,r,s,l,h){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!e.allowSelfLoops&&r===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var f=[p.key,!1,!1,!1];if(h?!u:!l)return f;if(h){var y=p.attributes;p.attributes=u(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return f}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new j("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Ae(e,r,{}),v=!0,r===s&&(g=m,w=!0)),g||(g=Ae(e,s,{}),w=!0),d=new z(i,o,m,g,l),e._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,g.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,g.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Ee(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Se,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?W:"directed"===e.type?U:q;u(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return u(s(t),"_attributes",{}),u(s(t),"_nodes",new Map),u(s(t),"_edges",new Map),u(s(t),"_directedSize",0),u(s(t),"_undirectedSize",0),u(s(t),"_directedSelfLoopCount",0),u(s(t),"_undirectedSelfLoopCount",0),u(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),u(s(t),"_options",e),Ce.forEach(function(e){return u(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Ee(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Ee(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Ee(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Ee(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):G(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,r=this._nodes.values();!0!==(n=r.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new N(function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}})},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach(function(e,i){t[n++]=function(e,t){var n={key:e};return h(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)});var i=new Array(this._edges.size);return n=0,this._edges.forEach(function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)}),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode(function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)}),e.forEachEdge(function(e,t,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)}),this;if(!c(e))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new D("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(r=o[t]);var h=r,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new D("Graph.import: invalid edges. Expecting an array.");for(t=0,n=o.length;t<n;t++){ye(s=o[t]);var m=s,g=m.source,f=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,g,f,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,g,f,y)}}return this},o.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},o.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach(function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)}),t},o.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new j('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new j("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new j("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),o=this._edges.values();!0!==(t=o.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},o.toJSON=function(){return this.export()},o.toString=function(){return"[object Graph]"},o.inspect=function(){var t=this,n={};this._nodes.forEach(function(e,t){n[t]=e.attributes});var i={},o={};this._edges.forEach(function(e,n){var r,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(r=l,l=c,c=r);var h="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===o[h]?o[h]=0:o[h]++,a+="".concat(o[h],". 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requires a dataset with a macromolecule column.";return void a(new l.Ap(r.divText(e)))}const p=r.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=r.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=r.p(`Kalign version: ${u.b9}`,"kalign-version"),f=r.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=r.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=r.input.bool("Selected Rows Only",{value:!1}),v=r.inputs([f,y,m]),w=r.button("Alignment parameters",()=>{v.hidden=!v.hidden,[f,y,m].forEach(e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")})},"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),v.hidden=!0,w.prepend(r.icons.settings(()=>null));const C=[p.root.style],S=[m.root.style,g.style];let A,x=d;const M=r.input.column("Sequence",{table:h,value:d,onValueChanged:async e=>{if(!e||e.semType!==o.SEMTYPE.MACROMOLECULE)return L.disabled=!0,await(0,s.cb)(0),void(M.value=x);x=e,L.disabled=!1,A=await I(M.value,h,t,C,S,p,E,f,y,m,b)},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE});M.setTooltip("Sequences column to use for alignment");const E=r.input.column("Clusters",{table:h,value:e.clustersCol});E.nullable=!0;const T=r.dialog("MSA").add(M).add(E).add(p).add(v).add(w).add(b).add(g).onOK(async()=>{await _(M,h,A,n,a)}),L=T.getButton("OK");if(M.fireChanged(),e.col)return A=await I(e.col,h,t,C,S,p,E,f,y,m,b),void await _(M,h,A,n,a);T.show()})}async function _(e,t,n,r,s){let a=null;const l=o.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has 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L(r,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,g.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,o,i,d.value,m.value,g.value,p.value,void 0,y.value)}return m.value=null,g.value=null,f.value=null,void L(r,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),E._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(4954),p=n(4574),m=n(1757),g=n.n(m),f=n(9124),y=n(9192),b=n(4870),v=n(4671);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe(()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK(()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}}).onCancel(()=>{g()(t).empty(),t=null,n=null}).show({modal:!0,fullScreen:!0})})),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe(e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}}))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class A extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new M:this.notation===c.Hi.SEPARATOR?new E(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class M extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get 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G=k-O,B=F-H;for(G>B?F=(H-=(G-B)/2)+G:k=(O-=(B-G)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(H+F)/2,N[3]=Math.max(k-O,F-H),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,o=1,s=0;s<T;s+=t)for(r=0,$=3;;){if(!(N[r+5]>=0)){if(N[r+0]<0){N[r+0]=s;break}if(N[r+5]=9*o,u=N[r+3]/2,N[(d=N[r+5])+0]=-1,N[d+1]=N[r+1]-u,N[d+2]=N[r+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]-u,N[d+2]=N[r+2]+u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+u,N[d+2]=N[r+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[r+1]+u,N[d+2]=N[r+2]+u,N[d+3]=u,N[d+4]=N[r+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,o+=4,P=n[N[r+0]+0]<N[r+1]?n[N[r+0]+1]<N[r+2]?N[r+5]:N[r+5]+9:n[N[r+0]+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+6]=n[N[r+0]+6],N[r+7]=n[N[r+0]+0],N[r+8]=n[N[r+0]+1],N[P+0]=N[r+0],N[r+0]=-1,P===(R=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27)){if($--){r=P;continue}$=3;break}N[R+0]=s;break}P=n[s+0]<N[r+1]?n[s+1]<N[r+2]?N[r+5]:N[r+5]+9:n[s+1]<N[r+2]?N[r+5]+18:N[r+5]+27,N[r+7]=(N[r+7]*N[r+6]+n[s+0]*n[s+6])/(N[r+6]+n[s+6]),N[r+8]=(N[r+8]*N[r+6]+n[s+1]*n[s+6])/(N[r+6]+n[s+6]),N[r+6]+=n[s+6],r=P}}if(e.barnesHutOptimize){for(g=e.scalingRatio,s=0;s<T;s+=t)for(r=0;;)if(N[r+5]>=0){if(v=Math.pow(n[s+0]-N[r+7],2)+Math.pow(n[s+1]-N[r+8],2),4*(p=N[r+3])*p/v<L){if(f=n[s+0]-N[r+7],y=n[s+1]-N[r+8],!0===I?v>0?(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*N[r+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*N[r+6]/v,n[s+2]+=f*w,n[s+3]+=y*w),(r=N[r+4])<0)break;continue}r=N[r+5]}else if((c=N[r+0])>=0&&c!==s&&(v=(f=n[s+0]-n[c+0])*f+(y=n[s+1]-n[c+1])*y,!0===I?v>0?(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w):v<0&&(w=-g*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=f*w,n[s+3]+=y*w):v>0&&(w=g*n[s+6]*n[c+6]/v,n[s+2]+=f*w,n[s+3]+=y*w)),(r=N[r+4])<0)break}else for(g=e.scalingRatio,a=0;a<T;a+=t)for(l=0;l<a;l+=t)f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8])>0?(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):v<0&&(w=100*g*n[a+6]*n[l+6],n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w):(v=Math.sqrt(f*f+y*y))>0&&(w=g*n[a+6]*n[l+6]/v/v,n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,g=e.scalingRatio,s=0;s<T;s+=t)w=0,f=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=g*n[s+6]*d):v>0&&(w=g*n[s+6]*d/v),n[s+2]-=f*w,n[s+3]-=y*w;for(g=1*(e.outboundAttractionDistribution?m:1),h=0;h<_;h+=3)a=i[h+0],l=i[h+1],u=i[h+2],b=Math.pow(u,e.edgeWeightInfluence),f=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===I?(v=Math.sqrt(f*f+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-g*b/n[a+6]):v>0&&(w=-g*b)):(v=Math.sqrt(Math.pow(f,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-g*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-g*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-g*b/n[a+6]):(v=1,w=-g*b)),v>0&&(n[a+2]+=f*w,n[a+3]+=y*w,n[l+2]-=f*w,n[l+3]-=y*w);if(!0===I)for(s=0;s<T;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+A)/(1+Math.sqrt(S)),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,E=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=E);else for(s=0;s<T;s+=t)1!==n[s+9]&&(S=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),A=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+A)/(1+Math.sqrt(S)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(S)))),M=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=M,E=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=E);return{}}},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.xe).filter(e=>e);t.forEach(e=>this.validateConnectionItem(e)),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach(t=>{const n=[],i=t.split(",");i[2].split("-").forEach((e,t)=>{const o=i[t],r=e.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})}),e.push(n)}),e}}var r=n(8438);class s{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach(e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter(e=>!!e).map(e=>(0,r.D)(e));n.push(...t),t.forEach((e,t)=>i.push(t%3==1?"Branch":"Backbone"))}else n.push((0,r.D)(e)),i.push("Backbone")}),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map((e,t)=>{if("Backbone"===e)return t}).filter(e=>void 0!==e),n=this.monomerTypes.map((e,t)=>{if("Branch"===e)return t}).filter(e=>void 0!==e);for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(i.pk),n=t[0].split(i.xe);this.simplePolymers=n.map(e=>new s(e)),this.connectionList=new o(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map(e=>e.monomers.length).reduce((e,t)=>e+t,0),t=Array.from({length:e},()=>[]);return this.bondData.forEach(e=>{e.forEach(e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)})}),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort((e,t)=>e-t).find(t=>e>=t);if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find(e=>t[e]===n);return this.simplePolymers.find(e=>e.id===i)}shiftBondMonomerIds(e,t){t.forEach(t=>{t.forEach(t=>{t.monomerIdx+=e})})}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach(n=>{e[n.id]=t,t+=n.monomers.length}),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach(n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)}),this.connectionList.getConnectionData().forEach(n=>{const i=[];n.forEach(t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)}),t.push(i)}),t}}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const i=n(8727),o=n(208),r=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),h=n(9029),u=n(2023),d=n(6939),p=n(4227),m=n(8708);function g({gen:e,validateName:t,schema:n,schemaEnv:i,opts:o},r){o.code.es5?e.func(t,h._`${u.default.data}, ${u.default.valCxt}`,i.$async,()=>{e.code(h._`"use strict"; ${f(n,o)}`),function(e,t){e.if(u.default.valCxt,()=>{e.var(u.default.instancePath,h._`${u.default.valCxt}.${u.default.instancePath}`),e.var(u.default.parentData,h._`${u.default.valCxt}.${u.default.parentData}`),e.var(u.default.parentDataProperty,h._`${u.default.valCxt}.${u.default.parentDataProperty}`),e.var(u.default.rootData,h._`${u.default.valCxt}.${u.default.rootData}`),t.dynamicRef&&e.var(u.default.dynamicAnchors,h._`${u.default.valCxt}.${u.default.dynamicAnchors}`)},()=>{e.var(u.default.instancePath,h._`""`),e.var(u.default.parentData,h._`undefined`),e.var(u.default.parentDataProperty,h._`undefined`),e.var(u.default.rootData,u.default.data),t.dynamicRef&&e.var(u.default.dynamicAnchors,h._`{}`)})}(e,o),e.code(r)}):e.func(t,h._`${u.default.data}, ${function(e){return h._`{${u.default.instancePath}="", ${u.default.parentData}, ${u.default.parentDataProperty}, ${u.default.rootData}=${u.default.data}${e.dynamicRef?h._`, ${u.default.dynamicAnchors}={}`:h.nil}}={}`}(o)}`,i.$async,()=>e.code(f(n,o)).code(r))}function f(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?h._`/*# sourceURL=${n} */`:h.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:i,self:o}=e;t.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,o.RULES)&&o.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return S(e,[],!1,t);const n=(0,o.getSchemaTypes)(e.schema);S(e,n,!(0,o.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:i,opts:o}){const r=n.$comment;if(!0===o.$comment)e.code(h._`${u.default.self}.logger.log(${r})`);else if("function"==typeof o.$comment){const n=h.str`${i}/$comment`,o=e.scopeValue("root",{ref:t.root});e.code(h._`${u.default.self}.opts.$comment(${r}, ${n}, ${o}.schema)`)}}function S(e,t,n,i){const{gen:o,schema:a,data:l,allErrors:c,opts:d,self:m}=e,{RULES:g}=m;function f(p){(0,r.shouldUseGroup)(a,p)&&(p.type?(o.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),A(e,p),1===t.length&&t[0]===p.type&&n&&(o.else(),(0,s.reportTypeError)(e)),o.endIf()):A(e,p),c||o.if(h._`${u.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,g)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach(t=>{x(e.dataTypes,t)||M(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)}),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&M(e,"use 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heights"}),this.valueAggrType=this.string(C.valueAggrType,M.valueAggrType,{category:w.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,M.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,M.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,M.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,M.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,M.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,M.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,M.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,M.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,M.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,M.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,M.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,M.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,M.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,M.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,M.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,M.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,M.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,M.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then(e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.render(E.Render,"monomerLib changed")}))}),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}}),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map(e=>e.name).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){v(e,this.slider.minRange,.1)&&v(t,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case C.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,e.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter(e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new h.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(u.gp.positionNames),t=this.seqCol.getTag(u.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map(e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0}).reduce((e,t)=>Math.max(e,t),0);this.positionNames=e?e.split(u.z1).map(e=>e.trim()):[...Array(o).keys()].map(e=>`${e+1}`),this.positionLabels=t?t.split(u.z1).map(e=>e.trim()):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new x(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,r=this.positions[e],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?f._S:o,s=t.get(n);this.positions[e].getFreq(r).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map(e=>e.getMinValue())));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile(e=>e<=t).map(e=>this.positions[e].sumPlotValueForHeight));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=r.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,r,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=r[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const 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r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],o=arguments[3],!(r=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]=o,this.emit("edgeAttributesUpdated",{key:r.key,type:"set",attributes:r.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,o){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use 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o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other 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n=n.next,{done:!1,value:e}}):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var o,r,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var h=r,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,r.undirected),e&&l)return u}}function le(e,t,n,i,o,r){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,o.in,r),e&&s))return s;if("in"!==i&&(s=a(e,o.out,r,i?void 0:o.key),e&&s))return s}if("directed"!==n&&(s=a(e,o.undirected,r),e&&s))return s}function ce(e,t,n,i,o,r,s){var a,l=n?re:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==i&&(a=l(e,o.in,r,s),e&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(e,o.out,r,s),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=l(e,o.undirected,r,s),e&&a))return a}var he=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ue(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var h=o(c.key,c.attributes);if(e&&h)return c.key}}}function pe(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var r,s=new ue;if("undirected"!==t){if("out"!==n){if(r=de(e,null,i,i.in,o),e&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=de(e,s,i,i.out,o),e&&r)return r;s.wrap(i.out)}}if("directed"!==t&&(r=de(e,s,i,i.undirected,o),e&&r))return r}function me(e,t,n){var i=Object.keys(n),o=i.length,r=0;return new N(function(){var s=null;do{if(r>=o)return e&&e.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}})}function ge(e,t,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),e&&u))return null}}function fe(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ue.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},ue.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Se={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ae(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,o,r,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!e.allowSelfLoops&&r===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(r),h=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new j("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);e._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,u.key=o,e.emit("edgeAdded",u),o}function Me(e,t,n,i,o,r,s,l,h){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!e.allowSelfLoops&&r===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(r),g=e._nodes.get(s);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var f=[p.key,!1,!1,!1];if(h?!u:!l)return f;if(h){var y=p.attributes;p.attributes=u(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return f}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new j("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Ae(e,r,{}),v=!0,r===s&&(g=m,w=!0)),g||(g=Ae(e,s,{}),w=!0),d=new z(i,o,m,g,l),e._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,g.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,g.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,v,w]}function Ee(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,r=t.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),r?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Te=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Se,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?W:"directed"===e.type?U:q;u(s(t),"NodeDataClass",i);var o="geid_"+ve()+"_",r=0;return u(s(t),"_attributes",{}),u(s(t),"_nodes",new Map),u(s(t),"_edges",new Map),u(s(t),"_directedSize",0),u(s(t),"_undirectedSize",0),u(s(t),"_directedSelfLoopCount",0),u(s(t),"_undirectedSelfLoopCount",0),u(s(t),"_edgeKeyGenerator",function(){var e;do{e=o+r++}while(t._edges.has(e));return e}),u(s(t),"_options",e),Ce.forEach(function(e){return u(s(t),e,t[e])}),d(s(t),"order",function(){return t._nodes.size}),d(s(t),"size",function(){return t._edges.size}),d(s(t),"directedSize",function(){return t._directedSize}),d(s(t),"undirectedSize",function(){return t._undirectedSize}),d(s(t),"selfLoopCount",function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount}),d(s(t),"directedSelfLoopCount",function(){return t._directedSelfLoopCount}),d(s(t),"undirectedSelfLoopCount",function(){return t._undirectedSelfLoopCount}),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",function(){return"graphology"}),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Ee(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Ee(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var r in n.undirected){t=n.undirected[r];do{Ee(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Ee(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Ee(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=e(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):G(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(t=i.next()).done;)n=t.value,o[r++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. 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p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new M:this.notation===c.Hi.SEPARATOR?new E(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))})}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null})}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))})}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = 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substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}})}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,async()=>{this._onRendered.next()})}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,()=>{this.logger.debug(`${n}, _onRendered event caught`)},()=>{this.invalidate(t)},e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class M extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout(()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()},0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class E extends p.O{emptyProps=new A("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new 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i,o,r=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(o=i||(i={})).EUCLIDEAN="EUCLIDEAN",o.MANHATTAN="MANHATTAN";var h=n(1858),u=n(5072),d=n.n(u),p=n(7825),m=n.n(p),g=n(7659),f=n.n(g),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),S=n.n(C),A=n(7939),x={};x.styleTagTransform=S(),x.setAttributes=b(),x.insert=f().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(A.A,x),A.A&&A.A.locals&&A.A.locals;var M=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};let E=null,T=null;function _(e,t){return e&&""!=e?e:t}n(2780);class I{constructor(){this.learningRate={uiName:"Learninig Rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via 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t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings(()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)},"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings(()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)},"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let o=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,o=!0),o||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let h=!1;this.preprocessingFuncSettingsIcon=s.icons.settings(async()=>{h?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),h=!h},"Modify encoding function 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t=()=>{this.columnFunctionsMap={},e.columns.toList().forEach(e=>{Object.keys(this.supportedFunctions).forEach(t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,o=this.supportedFunctions[t].units,r=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!o.length||e.meta.units&&o.includes(e.meta.units);r&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))})}),this.regenerateColInput()};t(),R()(e.columns).some(e=>!!e.getTag(a.Tags.SemanticDetectionDuration))||e.meta.detectSemanticTypes().then(()=>{t()})}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach(e=>this.preprocessingFunctionInputRoot.append(e))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach(e=>this.similarityMetricInputRoot.append(e)),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach(n=>{const i=t[n],o="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(o.root),i.disable?(o.enabled=!1,s.tooltip.bind(o.input??o.root,i.disableTooltip??"")):s.tooltip.bind(o.input??o.root,i.tooltip)}),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let o=2;o<t.inputs.length;o++){const r=t.inputs[o];(this.preprocessingFunctionSettings[r.name]||n.inputParams[t.inputs[o].name].value||r.defaultValue)&&(this.preprocessingFunctionSettings[r.name]=this.preprocessingFunctionSettings[r.name]??n.inputParams[r.name].value??r.defaultValue);const s=i.find(e=>e.property.name===r.name);s&&(null!==this.preprocessingFunctionSettings[r.name]&&void 0!==this.preprocessingFunctionSettings[r.name]&&(s.value=this.preprocessingFunctionSettings[r.name]),s.onChanged.subscribe(e=>{this.preprocessingFunctionSettings[r.name]=e}),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}}var k=n(9713),H=n(6295);const F=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class B{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),f=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),p=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(u.set(r,i),s<m&&(m=s),a>g&&(g=a),e())}})}await Promise.all(l),n&&u.forEach((e,t)=>{u[t]=(e-m)/(g-m)}),i(u)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)r[e]<m&&(l[p]=u[e],c[p]=d[e],h[p]=r[e],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach((e,t)=>r[t].threshold=o);const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:u,endIdx:p,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),h(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const p=await Promise.all(u),m=p.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(m),f=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),h=new Array(this._workerCount),u=e[0].length,d=e.map(e=>e[t]),p=Math.ceil(u/this._workerCount);for(let t=0;t<this._workerCount;t++)h[t]=new Promise((n,i)=>{const h=t*p,m=t===this._workerCount-1?u:(t+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(h,m)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const m=await Promise.all(h),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:h,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}});const d=await Promise.all(u),p=d.reduce((e,t)=>e+t.distance.length,0),m=new Float32Array(p);let g=0;for(const e of d)m.set(e.distance,g),g+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=F(e[l])||F(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,j,W=n(8774);(j=V||(V={})).none="none",j.bold="bold",j.dashed="dashed";class U{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new W.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,h,u,d,p,m,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const S=this.sp.pointToScreen(this.lines.to[e]);let A=null==S?void 0:S.x,x=null==S?void 0:S.y;const M=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&A&&x&&Math.hypot(A-w,x-C)/M>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[e])?null===(u=this.lines.widths)||void 0===u?void 0:u[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let S=null;if(b){t=this.getLineLength(w,C,A,x);const o=this.getPointOnDistance(w,C,A,x,i,t),r=this.getPointOnDistance(A,x,w,C,n,t);w=o.x,C=o.y,A=r.x,x=r.y,S=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,A,x,e):this.findControlPoint(b,A,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(S.x,S.y,A,x)}else(!this.lines.skipShortLines||Math.pow(A-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(A,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,A,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,A,x,i,t),n=b?S.x:w,o=b?S.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,h,u)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,h=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,h)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new W.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(e-a),g=Math.abs(t-p),f=m+g;(!d||d>f)&&(d=f),u[r]=Math.max(m,g),c[r]=a,h[r]=p}for(let e=0;e<c.length;e++)u[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,h[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const s=n-o*((n-e)/r),l=i-o*((i-t)/r);return new a.Point(s,l)}findControlPoint(e,t,n,i,o,r){const s=t+(i-t)/2,l=n+(o-n)/2;let c=s-t,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const q="dimensionality-reducer-terminate-event";var z,Y,K=n(3629);async function Z(e,t,i,o,s,a,l){let c=await async function(e,t,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q).subscribe(()=>{try{u?.terminate()}finally{d.unsubscribe()}});u.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{F(n)||F(i)?(d.unsubscribe(),e?h(e):c(t),setTimeout(()=>u.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,o,s,a,l);return c=c.map(e=>(0,K.S8)(e)),c}(Y=z||(z={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const X={[z.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[z.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return M(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(T&&(T.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!T||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return T=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),T}catch(e){return console.error("Failed to create device with required limits",e),T=yield E.requestDevice(),T}}return T})}();if(!s)return null;const a=Object.values(J);if(n.some(e=>!a.includes(e)))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(z).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(r.length!==e.length||r.length!==n.length||r.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some(t=>t.length!==e[0].length))throw new Error("All entry lists must be the same length");const c=e.length,h=e[0].length,u=e.map((e,t)=>function(e,t=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,r;let s=null;const a=e.some(e=>"string"==typeof e)?(s="STRING",e.map(e=>new Uint32Array(e.split("").map(e=>e.charCodeAt(0))))):e.some(e=>"number"==typeof e)?(s="NUMBER",e.map(e=>new Float32Array([e]))):"object"==typeof e[0]&&e.some(e=>"_data"in e&&"_length"in e)?(s="BITARRAY",e.map(e=>e._data)):e.some(e=>e instanceof Float32Array)?(s="FLOAT32ARRAY",e):e.some(e=>e instanceof Uint32Array)?(s="UINT32ARRAY",e):e.some(e=>e instanceof Int32Array)?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map(e=>e.length));if(!ne[s]||!ne[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const h=c.reduce((e,t)=>Math.max(e,t),0),u=te[t](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach((e,t)=>{p.set(e,t*h)});let m="",g=0,f="FLOAT32ARRAY",y=null;if(t===J.NEEDLEMAN_WUNSCH||t===J.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce((e,t)=>Math.max(e,t.charCodeAt(0)),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map(()=>new Array(e+1).fill(0)),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map(()=>new Float32Array(e+1));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce((e,t)=>Math.min(e,t),p[0]),t=p.reduce((e,t)=>Math.max(e,t),p[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,r[t]));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=z.MANHATTAN);let d=u.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*h);u.forEach((e,t)=>{g.set(e.arraySizes,t*h)});const f=1e4,y=100,b=u.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,S=h*(h-1)/2,A=Math.ceil(S/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${A} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,u.map(e=>e.maxEntryLen),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(S/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?S-1:(e+1)*R,n=h-2-Math.floor(Math.sqrt(-8*t+4*h*(h-1)-7)/2-.5),i=t-h*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce((e,t)=>e+t.sourceArraySize,0),H=u.reduce((e,t)=>e+t.suppInfoSize,0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const D=15&G;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,f).set(I),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(L),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(N),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f).set(P),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g.length).set(g),W+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,W,c).set(o),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of u){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,W,n).set(e.flatSourceArray),W+=n*t.BYTES_PER_ELEMENT}V.unmap();const U=H*Uint32Array.BYTES_PER_ELEMENT;let q=U;const Y=15&U;0!==Y&&(q+=16-Y),q=Math.max(q,16);const K=s.createBuffer({label:"supp info buffer",size:q,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=K.getMappedRange();let X=0;for(const e of u)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(Z,X,e.suppInfoBuffer.length).set(e.suppInfoBuffer),X+=e.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ee=Q;const ie=15&Q;0!==ie&&(ee+=16-ie);const re=s.createBuffer({label:"results buffer",size:ee,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:re}}]}),ae=s.createBuffer({label:"results out buffer",size:re.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],he=[];let ue=!1;for(;!ue;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(_),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(re,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const r=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,F);o+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,ue=new Uint32Array(i,o,f).every(e=>1===e);const h=c.reduce((e,t)=>e+t,0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(u.set(r.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(u),ce.push(d),he.push(p),ae.unmap()}const de=le.reduce((e,t)=>e+t.length,0),pe=new Uint32Array(de),me=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)pe.set(le[e],fe),me.set(ce[e],fe),ge.set(he[e],fe),fe+=le[e].length;return V.destroy(),K.destroy(),re.destroy(),ae.destroy(),{i:pe,j:me,distance:ge}})}function oe(e,t,n,i){return e.map((e,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${ee[e](t[i],i)}\n        }\n      `).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${e.length}>;\n        ${e.map((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`).join("\n")}\n        ${X[i](e.length)}\n      }\n    \n    `}let re=0;const se="cliffsDf",ae=new h.Subject,le="SALI",ce="line index",he=["From","To"],ue="filterCliffs";async function de(e,t,i,o,l,c,h,u,d,p,m,g,f,y,b,v,w){re++;const C=c/100;let S,A=!1;const x=g.inputs,M=await g.apply({[x[0].name]:t,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let E=[];if(u===N){const t=await function(e,t,i,o,r,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise((e,t)=>{u=e,h.onmessage=t=>{setTimeout(()=>h.terminate(),100),e(t.data.res)},h.onerror=e=>{setTimeout(()=>h.terminate(),100),t(e)}}),terminate:()=>{try{u(null),h.terminate()}catch(e){console.error(e)}}}}([M.entries],c,[1],"MANHATTAN",[h],[M.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init(e=>t.clusters[e]),E=[t.embedX,t.embedY]}else E=await Z([M.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[M.options??{}]});if(E.length!==i.length)throw new Error("Number of axes names 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a.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,_.saliVals,_.n1,_.n2,0,l);e.columns.add(I);const L=_.cliffsBitSet,P=function(e){const t=e.filter(e=>e!==1/0),n=t.reduce((e,t)=>Math.min(e,t),Number.MAX_VALUE);return{max:t.reduce((e,t)=>Math.max(e,t),n),min:n}}(_.saliVals),$=.8/(P.max-P.min),O=r.shell.tv?.dataFrame===e?r.shell.tv:r.shell.getTableView(e.name),H=O.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),F=function(e,t,n,i,o,r,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return he.forEach((e,t)=>{h.columns.addNewString(e).init(e=>n.get(0===t?c.from[e]:c.to[e])),function(e,t){Object.keys(t).forEach(n=>{e.tags[n]=t[n]})}(h.col(e),r),h.col(e).semType=o}),h.columns.addNewFloat("Δ activity").init(e=>Math.abs(i.get(c.from[e])-i.get(c.to[e]))),h.columns.addNewInt(ce).init(e=>e),h.columns.addNewFloat(le).init(e=>t.saliVals[e]),h.columns.addNewFloat("Similarity").init(e=>t.simVals[e]),h.name=`${se}${re}`,{lines:c,linesDf:h}}(e,_,t,l,p,m,P,$);F.lines.skipMultiLineCalculation=!0,F.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const G=new U(H,i[0],i[1],F.lines,V.none),B=b?b(F.linesDf,he).sort([le],[!1]):F.linesDf.plot.grid().sort([le],[!1]);B.col(ce)&&(B.col(ce).visible=!1),e.temp[".cliffsDfGrid"]=B;const j=s.button(`${F.linesDf.rowCount} cliffs`,()=>{const e=R()(O.viewers).some(e=>e.dataFrame.name===`${se}${re}`);w&&!e&&O.addViewer(B),O.dockManager.dock(B,"down",null,"Activity cliffs",v??.2)});j.classList.add("scatter_plot_link","cliffs_grid");const W=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(H.dataFrame.setTag(ue,i[0]),e.filter.and(L),ae.next(i[0])):(H.dataFrame.setTag(ue,""),e.filter.setAll(!0),ae.next(""))}});H.root.prepend(s.divH([j,W.root],"cliffs_div")),ae.subscribe(e=>{W.enabled=""===e||e===i[0]}),e.onRowsFiltering.subscribe(()=>{W.value&&e.filter.and(_.cliffsBitSet)});const q=r.events.onViewerClosed.subscribe(e=>{e.args.viewer===H&&(O.dockManager.close(B.root),q.unsubscribe(),O.subs=O.subs.filter(e=>e!==q))});return O.subs.push(q),F.linesDf.onCurrentCellChanged.subscribe(()=>{for(let e=0;e<F.linesDf.rowCount;e++)F.lines.widths[e]=e===F.linesDf.currentRowIdx?3:1;G.linesToRender=F.lines;const n=F.linesDf.currentCol&&F.linesDf.currentCol.name===he[1]?F.lines.to:F.lines.from,o=-1!==F.linesDf.currentRowIdx?F.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=F.linesDf.currentRowIdx;G.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(e,t,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=e/s,c=t/a,h=Math.min(l,c),u=e/h*5,d=t/h*5,p=(n<o?n:o)+s/2-u/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],F.lines.from[n]),H.dataFrame.get(i[1],F.lines.from[n]),H.dataFrame.get(i[0],F.lines.to[n]),H.dataFrame.get(i[1],F.lines.to[n]));H.zoom(a,h,c,u),W.value?e.filter.and(L):!0===W.enabled&&e.filter.setAll(!0),setTimeout(()=>{!function(e,t,n,i,o,a,l,c,h){const u=t.getPane("Cliff Details");s.empty(u.root);const 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pe,me=n(6863),ge=n(2003),fe=n(3516),ye=n(6718),be=n(3077),ve=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var we=n(9192);class Ce{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Se extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ce}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,xe,Me;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Te(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function _e(e,t,i,o,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==h.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??r.shell.tableView(e.name)??r.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let S;try{const A=Ee(e);function x(n,o,r){let c=null,h=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),h=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),h=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!S&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}))),g[l.YP]&&(S?.root&&s.setUpdateIndicator(S.root,!1),c.init(e=>r[0]?r[0][e]:void 0),h.init(e=>r[1]?r[1][e]:void 0));const u=n/o*100;C.update(u,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function M(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}),s.setUpdateIndicator(S.root,!0));const p=r.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&S?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===S?.getOptions()?.look?.title&&(r.events.fireCustomEvent(q,{}),p.unsubscribe(),n?.(),C.close())}),f=new Promise(async(r,s)=>{try{n=r;const s=[];let a=o,d=c,p=u;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<h.length;++e){const n=h[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[r]:o[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map(e=>e.entries),i,a,d,u,m,g[l.vb]?void 0:x))}catch(e){s(e)}}),y=await f;return C.close(),p.unsubscribe(),y}const E=await M();if(p&&E){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(E[0],E[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>_[e].toString()),S&&(S.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(E){const N=e.columns.byName(A[0]),P=e.columns.byName(A[1]);if(N.init(e=>E[0][e]),P.init(e=>E[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){r.shell.error("Post-processing failed"),console.error(O)}if(S)return s.setUpdateIndicator(S.root,!1),S.helpUrl="/help/compute/sequence-space",S}}catch(k){r.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),S&&s.setUpdateIndicator(S.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(xe||(xe={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Me||(Me={})),Object.prototype.toString;var Ie=n(6873),Le=n(4356),Ne=n(6717),Pe=n(4025),Re=n(4870),$e=n(3856),Oe=n(6882),ke=n(7278),He=n(5553),Fe=n(6642),Ge=n(3599),Be=n(673),De=n(8312);class Ve extends Fe.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,kr.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,De.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var je=n(4139);const We=ge.zS;function Ue(e){const t=!R().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class qe extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=kr.seqHelper}getRendererBack(e){const[t,n,i]=(0,Fe.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,He.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,Fe.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(kr.properties?kr.properties.maxMonomerLength:4)??50;if($e.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag($e.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new Oe.Jy(a,l,kr.logger,d,()=>{const{font:e,fontWidth:t}=Oe.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:u.isMsa()?8:0,monomerToShort:We}}),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,p.init().then(()=>{})),p.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class ze extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[ge.gp.separator],u=this.tableCol.meta.units;i=(0,Oe.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Pe.j.notationProvider]?.separatorSplitter??(0,ke.Iv)(u,h),g=m(d),f=m(p),y=R().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=R().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),v=this.tableCol.getTag(ge.gp.alphabet);Ke(e,t,n,i,o,y,b,v===ge.YI.RNA||v===ge.YI.DNA?Ge.o.NUCLEOTIDE:Ge.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ze(t,n)),o}}class Ye extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return je.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){ze.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Ke(e,t,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ve.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const u=e.measureText(Ue(r).join("")),d=e.measureText(Ue(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,e.canvas.width=p+4*r.length);let m=Math.max(t,t+(i-(p+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const u=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Oe.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Oe.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,$e.oZ)(e,n,m,g-u,i,o,{color:d,pivot:0,left:!0}),p=(0,$e.oZ)(e,c,m,g+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[t]=Ze(n,c,d,r,g,u,o))}else m=(0,$e.oZ)(e,n,m,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Ze(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ue([e]).join("")).width,h=l.measureText(Ue([t]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,$e.oZ)(l,e,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,$e.oZ)(l,t,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Xe,Je=n(8070),Qe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Xe||(Xe={}));const et=new class{constructor(){this.regionTypes=[Xe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Qe.fH.Entropy,this.filterSource=Qe.Fo.filterSource}};var tt=n(7602),nt=n(250);const it=Xe;var ot,rt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(ot||(ot={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(rt||(rt={}));const st=et;class at extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(rt.skipEmptyPositions,st.skipEmptyPositions,{category:ot.DATA}),this.regionTypes=this.stringList(rt.regionTypes,st.regionTypes,{category:ot.DATA,choices:Object.values(it).filter(e=>e!=it.Unknown)}),this.chains=this.stringList(rt.chains,st.chains,{category:ot.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(rt.fitWidth,st.fitWidth,{category:ot.LAYOUT}),this.positionWidth=this.float(rt.positionWidth,st.positionWidth,{category:ot.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(rt.positionHeight,st.positionHeight,{category:ot.LAYOUT,choices:Object.keys(Qe.fH)}),this.filterSource=this.string(rt.filterSource,st.filterSource,{category:ot.BEHAVIOR,choices:Object.values(Qe.lT)}),this.viewSyncer=new tt.g(kr.logger)}static viewerCounter=-1;viewerId=++at.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case rt.regionTypes:case rt.chains:this.setData(this.regions)}switch(e.name){case rt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case rt.fitWidth:case rt.positionWidth:this.calcSize();break;case rt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case rt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;kr.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){kr.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){kr.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=s.table(this.chains,e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(Qe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),kr.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){kr.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[nt.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(rt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[nt.n5.filterSource]:this.filterSource})}}})}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Je.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class lt{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ct{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new ct(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new lt);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new lt);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ut(e,t,n="Morgan",i=1,o=.6){const r=e.length,s=kr.seqHelper.getSeqHandler(e),a=Array(r);let l=1;const c=new Map,h=e.categories,u=e.getRawData();for(let t=0;t<r;t++){if(null===h[u[t]]||e.isNone(t)){a[t]=null;continue}a[t]="";const n=s.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[t]+=c.get(i)}}let d={};if(t===me.Z.MONOMER_CHEMICAL_DISTANCE||t===me.Z.NEEDLEMANN_WUNSCH){const e=Array.from(c.keys()),r=await(0,ye.A7)(e,n),s={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{s[c.get(e)]=t});const l=a.reduce((e,t)=>Math.max(e,t?.length||0),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},t===me.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var dt=n(4954);function pt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))}),t}function mt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=kr.seqHelper.getSeqHandler(e.seqCol),r=o.defaultBiotype,a=ft(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),r,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(yt(i)),t.append(gt("Activity delta",Math.abs(n[0]-n[1]))),t.append(gt("Cliff",e.sali)),t}function gt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function ft(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=kr.monomerLib;return Ke(r,0,0,0,30,R().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),R().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function yt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function bt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class vt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class wt extends vt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[me.Z.NEEDLEMANN_WUNSCH,me.Z.HAMMING,me.Z.LEVENSHTEIN,me.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",me.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===me.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}}const Ct={gapPenalty:1,matchScore:1,gapSymbol:ve.b9[ve.Hi.FASTA],localAlignment:!1};class St extends wt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Re.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Re.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ut(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new D).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=a.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(e.currentRowIdx),u=function(e,t,n={}){const i={...Ct,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let h=i.localAlignment?c[0]:r,u=i.localAlignment?c[1]:s,d=new Array(0),p=new Array(0);for(;h>0&&u>0;){const n=Math.max(a[h-1][u-1],a[h-1][u],a[h][u-1]);a[h][u]==a[h-1][u-1]+i.matchScore&&n==a[h-1][u-1]?(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1):a[h][u]==a[h-1][u]-i.gapPenalty?(p.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):a[h][u]==a[h][u-1]-i.gapPenalty?(d.push(i.gapSymbol),p.push(t.getCanonical(u-1)),u-=1):(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1)}d=[...R().count(0).take(h).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?R().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],p=[...R().count(0).take(u).map(e=>t.getCanonical(e)),...p.reverse(),...i.localAlignment?R().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const m=h,g=u;return m>g?p=[...new Array(m-g).fill(i.gapSymbol.valueOf()),...p]:d=[...new Array(g-m).fill(i.gapSymbol.valueOf()),...d],p.length>d.length?d.push(...new Array(p.length-d.length).fill(i.gapSymbol.valueOf())):p.push(...new Array(d.length-p.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:p.join(""),seq1Splitted:new ke.Mu(d,i.gapSymbol),seq2Splitted:new ke.Mu(p,i.gapSymbol)}}(c,h),d=ft(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(yt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",()=>t,!0),r.shell.o=p.root}}class At extends wt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Re.Kd)(i,t.name,450,30),(0,Re.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ut(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new B(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,h=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),u=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[h(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var xt,Mt=n(5433),Et=n(3890),Tt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(xt||(xt={}));class _t{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class It extends _t{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Lt extends It{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(xt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(xt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(xt.TYPE)&&-1!==e.indexOf(xt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,xt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<xt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,xt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,xt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+xt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=xt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends It{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Pt{constructor(){}static getInstance(e){if(Pt.isMolfileV2K(e))return new Lt(e);if(Pt.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Lt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Rt=n(6197),$t=n(9124),Ot=n(3527);class kt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++kt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ht extends kt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Ft extends kt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Gt extends kt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Bt extends kt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Dt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Bt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Dt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Vt={[Ge.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ge.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ge.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ge.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ge.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ge.o.CHEM]:{R:"#eeeeee"},[Ge.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},jt=/[\w()]+/,Wt=RegExp(String.raw`\(${jt}(,${jt})+\)`),Ut=e=>{const t=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,t,e),t},qt=new Ot.Mi([255,255,255]),zt=new Ot.Mi([0,0,0]),Yt=.7*(0,K.wQ)(qt);class Kt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==ve._S||t===ve.b9[ve.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{kr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,$t.fA)(e,t),o=(0,Rt.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Ge.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Ge.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ve._S||"*"==i?s=r.wem=new Ht(n):n===Ge.o.NUCLEOTIDE&&"N"===i||n===Ge.o.AA&&"X"===i||(Ge.o.CHEM,0)||Wt.test(i)?s=r.wem=new Ft(n,i):r.lib||(s=r.wem=new Gt(n,i,this.isEmpty)),s||(s=r.wem=Dt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Rt.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),r=this.getMonomer(n,t);if(r){const e=r.symbol,[t,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?Ut(r.molfile):r.smiles?s.divV([Ut(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=ve._S){let e=r.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(e))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Ot.Mi([...o.map(e=>e+1)]),s=(0,K.KE)(r,qt)/((0,K.wQ)(r)*(0,K.wQ)(qt)),l=i(n.backgroundcolor),c=new Ot.Mi([...l.map(e=>e+.01)]);let h;h=(0,K.KE)(c,qt)/((0,K.wQ)(c)*(0,K.wQ)(qt))<s?l:o;let u=new Ot.Mi(h);const d=(0,K.wQ)(u);return d>Yt&&(u=(0,K.dC)(zt,u,Yt/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Rt.Y)(e),r=this.getMonomer(o,t);let s;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){kr.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(s=e[i])}if(!s){const t=Vt[e],n=t?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!s&&t)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Zt=n(5488),Xt={};Xt.styleTagTransform=S(),Xt.setAttributes=b(),Xt.insert=f().bind(null,"head"),Xt.domAPI=m(),Xt.insertStyleElement=w(),d()(Zt.A,Xt),Zt.A&&Zt.A.locals&&Zt.A.locals;class Jt extends Kt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{kr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,Rt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Pt.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Le.ub)().then(e=>{this.assignDuplicatePreferences(e)}):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new Qt(e,`override: ${++Jt.overrideCounter}, ${t}`,this)}}class Qt extends Kt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,o){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map(e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n})}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class tn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nn=n(7433),on=n.n(nn),rn=n(1913),sn=n.n(rn);class an{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(on())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});sn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var ln=n(8604);class cn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let o;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise(e=>o=e)]),this.eventManager.updateValidLibraryFileListRequested$.subscribe(()=>{this.updateValidLibList().then(()=>{}),r||(r=!0,o())}),this.eventManager.updateValidSetFileListRequested$.subscribe(()=>{this.updateValidSetList().then(()=>{})})}static objCounter=-1;objId=++cn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await r.dapi.files.readAsText(ln.gt),o=JSON.parse(i),s=new an(o);return new cn(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await r.dapi.files.exists(ln.so+`${t}`))return void r.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await r.dapi.files.writeAsText(ln.so+`${t}`,e),await this.updateValidLibList(),await r.dapi.files.exists(ln.so+`${t}`)?r.shell.info(`Added ${t} HELM library`):r.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),r.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await r.dapi.files.delete(ln.so+`${e}`),await this.updateValidLibList(),r.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await r.dapi.files.exists(ln.so+`${e}`)?r.shell.error(`Failed to delete ${e} library`):r.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),o=await i.readAsText(t);n=JSON.parse(o);const r={},s=[];return n.forEach(e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(r[t]={},s.push(t)),r[t][n]=e}),new Jt(r,t)}async loadSetFromFile(e,t,n){let i={};const o=new a.FileSource(t),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map(([t,n])=>{const i=t,o=n.polymerType,r=n.monomerType,s=n.set;return new en(e,i,o,r,s)});return new tn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await r.dapi.files.readAsText(ln.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${ln.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return kr.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{kr.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void kr.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await r.dapi.files.readAsText(ln.Es+`${e}`):t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),kr.logger.debug(`${e}, OUT`)}),kr.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some((e,n)=>e!==t[n])}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some((e,n)=>e!==t[n])}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(ln.so).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(ln.so.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(ln.Es).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(ln.Es.length))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise(e=>{const t=this._libFilesUpdateSubject$.pipe((0,k.skip)(1)).subscribe(n=>{e(n),t.unsubscribe()})})}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class un{logger;_monomerLib=new Jt({},"MAIN");_monomerSets=new tn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Je.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++un.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return un.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await cn.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then(e=>[e.getValidLibraryPaths()]),(0,Le.ub)()]),o=t.filter(e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n});let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map(e=>this.readLibrary(ln.so,e).catch(t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Jt({},e,n)}).finally(()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then(e=>[e.getValidSetPaths()])]),n=t.filter(e=>!0);let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map(t=>this.readSet(ln.Es,t).catch(e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn("Broken monomer set",[],t,n)}).finally(()=>{e.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))]);this._monomerSets.updateSets(r)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Le.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter(t=>!e.includes(t)),await(0,Le.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter(e=>!t.includes(e))}async loadMonomerLibForTests(){await(0,Le.Eu)(ln.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new un(kr.logger);return e._eventManager=hn.getInstance(),e})()),e}}var dn=n(1757),pn=n.n(dn),mn=n(3017),gn={};gn.styleTagTransform=S(),gn.setAttributes=b(),gn.insert=f().bind(null,"head"),gn.domAPI=m(),gn.insertStyleElement=w(),d()(mn.A,gn),mn.A&&mn.A.locals&&mn.A.locals;var fn=n(3151);class yn{constructor(e,t=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add 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not match dataframe row count ${t.rowCount}`);return await Promise.all(new Array(e.length).fill(null).map(async(e,n)=>Hn(t.rows.get(n))))}function En(e){try{const t=a.DataFrame.create(e.length),n=new Set;for(const t of e)t.rgroups.forEach(e=>{e.label&&n.add(e.label)});const i=Array.from(n);i.sort();for(const[e,n]of Object.entries(xn))if(t.columns.addNew(e,n),e===Cn.R_GROUPS)for(const e of i)t.columns.addNew(e,a.COLUMN_TYPE.STRING);t.col(Cn.SYMBOL).semType="Monomer",t.col(Cn.SYMBOL).setTag($e.Mn.applyToBackground,"true");for(let n=0;n<e.length;n++){let o=$n(e[n].rgroups,e[n].smiles,e[n].molfile);o=_n(o),e[n].rgroups=Nn(e[n].rgroups);const r=i.map(t=>{const i=e[n].rgroups.find(e=>e.label===t);return i?Ln(i,"capGroupSmiles"):""});let s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(Cn.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}}return t.col(Cn.MONOMER).semType=a.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=a.SEMTYPE.MOLECULE}),t}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}}class Tn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Cn.NAME).width=100,this.tv.grid.col(Cn.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=fn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Pn(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(Cn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new Tn(e)}return this.instance}static async getNewInstance(){const e=await un.getInstance();return await e.awaitLoaded(),await e.loadLibrariesPromise,new Tn(e)}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map(e=>({...e,lib:void 0,wem:void 0})),null,2);e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await r.dapi.files.writeAsText(ln.so+e,n),await this.monomerLibManamger.loadLibraries(!1),r.shell.v=await this.getViewRoot(e)}catch(e){r.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",async()=>{const t=i(n.value);if(t)r.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){r.shell.error("Error creating library"),console.error(e)}o.close()}}).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Hn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Hn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await Hn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})})),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter(e=>e.name===Tn.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(r.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?r.shell.v=e:Tn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){r.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const o=s.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=s.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=s.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),h=s.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Hn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Hn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});s.tooltip.bind(h,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const u=s.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return r.shell.error("No library selected");let t=null;try{t=await r.dapi.files.readAsText(ln.so+e)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return r.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=Tn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Hn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(ln.so,e),!this.activeMonomerLib)return r.shell.error(`Library ${e} not found`),a.DataFrame.create();return En(this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t))))}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame;let t=this.libInput.value;if(e&&t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Hn(e.rows.get(n)))),i=JSON.stringify(n.map(e=>({...e,lib:void 0,wem:void 0})),null,2);t.endsWith(".json")||(t+=".json"),await r.dapi.files.writeAsText(ln.so+t,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const In=["alternateId","capGroupName","capGroupSMILES","label"];function Ln(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Nn(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(In,e),n=Ln(t,"capGroupSMILES"),i=Ln(t,"alternateId"),o=Ln(t,"capGroupName"),r=Ln(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class Pn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",async()=>{const e=this.validateInputs();e?r.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=$n([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await wn(kn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new yn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?r.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new yn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Nn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&wn(kn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=$n(e.rgroups,e.smiles,e.molfile),n=r.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await r.dapi.files.readAsText(ln.so+t);i=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const o=e.map(e=>Rn(i,t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=o.map(e=>i[e]),l=s.divV(a.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",async()=>{i=i.filter(e=>!a.includes(e)),await r.dapi.files.writeAsText(ln.so+t,JSON.stringify(i,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map(e=>e.symbol).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),u.close()}).show()}async addMonomerToLib(e,t){let n=[];try{const e=await r.dapi.files.readAsText(ln.so+t);n=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const i=Rn(n,t=>t.symbol===e.symbol&&t.polymerType===e.polymerType),o=this.getMonomersDataFrame()?.col(Cn.MONOMER)?.toList()?.findIndex(t=>t===e.smiles),a=async()=>{try{const i=n.findIndex(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType);i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(ln.so+t,JSON.stringify(n,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,r.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){r.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const e=await Hn(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",()=>{e.close(),a()}).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!r.chem.checkSmiles(e))return void r.shell.warning("Invalid SMILES");e=$n([],e);let t=r.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=On(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Rn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function $n(e,t,n){const i=!t||!r.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(o,e),o=_n(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function On(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function kn(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=Ln(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)}),n}async function Hn(e){let t;try{t=JSON.parse(e.get(Cn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Cn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=On(i)}catch(e){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Cn.NATURAL_ANALOG);const s=e.get(Cn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Cn.R_GROUPS)??"[]"),!o&&s){const e=await wn(kn(n,l),s);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Cn.SYMBOL),name:e.get(Cn.NAME),molfile:i,smiles:n,polymerType:s,monomerType:e.get(Cn.MONOMER_TYPE),naturalAnalog:o,id:e.get(Cn.ID),rgroups:l,meta:t,author:e.get(Cn.AUTHOR),createDate:e.get(Cn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Bn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Gn(e));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,e),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await un.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Dn._instance.refresh())),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Le.ub)();const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Bn(n,this.monomers[t][n],o,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=s.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void r.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void r.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=s.input.choice("Default Library",{items:n,nullable:!0});s.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else r.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=s.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}async function Vn(){await qn.showDialog()}async function jn(e=!0){return await zn.showView(e)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const e=new Wn,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Wn.instancePromise}static async reloadWidget(){const e=await Wn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe(()=>this.promptToAddLibraryFiles()),new a.Widget(e)}async getWidgetContent(){const e=await Un.createControlsForm();return pn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&pn()(e)&&pn()(e).removeClass("ui-form-condensed")},200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe(()=>{this.updateControlsForm()}),this.fileManager.eventManager.librarySelectionRequested$.subscribe(([e,t])=>{this.updateLibrarySelectionStatus(t,e)})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){kr.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then(e=>e.getFileManager()),await(0,Le.ub)()]);return new Un(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.wideForm(e,void 0);return pn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();pn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;kr.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const o=s.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=s.icons.edit(async()=>{r.shell.v=await(await Tn.getInstance()).getViewRoot(e)},"Edit monomer library");return s.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),kr.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Le.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter(e=>e!==t):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK(async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),r.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}class qn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){qn._instance||(qn._instance=new qn,qn._instance.closeDialogSubject$.subscribe(()=>{qn._instance.dialog=void 0})),qn._instance.dialog||(qn._instance.dialog=await qn._instance.getDialog()),qn._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});pn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>e.addLibraryFile(),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class zn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",()=>t.addLibraryFile(),"Upload new HELM monomer library"),o=s.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(l),this._view.name=zn.viewName,e&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then(()=>{setTimeout(()=>{const e=Array.from(l.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe(()=>{try{const e=zn._instance;e&&e._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return zn._instance||(zn._instance=new zn),zn._instance._duplicateManager||(zn._instance._duplicateManager=await Dn.getInstance()),zn._instance.libManager||(zn._instance.libManager=await un.getInstance()),e&&zn._instance._view&&Array.from(r.shell.views).find(e=>e.id&&e.id===zn._instance._view.id)?(r.shell.v=zn._instance._view,await zn._instance._duplicateManager.refresh(),zn._instance._view):(zn.closeExistingViews(),zn._instance.getView(e))}static closeExistingViews(){Array.from(r.shell.views).filter(e=>e.name===zn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await un.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=h(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=o.value;return e.endsWith(".json")||(e+=".json"),e}function h(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(h),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{a.Utils.download(c(),JSON.stringify(n))}).addButton("Save",async()=>{i.close();const e=c(),t=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(t,e,!1);const n=await(0,Le.ub)();n.exclude=l,await(0,Le.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(t){r.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Yn,Kn=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class Zn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe(e=>Kn(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=r.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),()=>Kn(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),()=>Kn(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),()=>Kn(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Zn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Kn(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Je.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return Kn(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Kn(this,void 0,void 0,function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Kn(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return Kn(this,void 0,void 0,function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Zn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Kn(this,void 0,void 0,function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}Zn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Yn||(Yn={}));var Xn=n(966),Jn=n(608),Qn=n(1619);class ei{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${kr.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case nt.n5.fixWidth:case nt.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ti{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ni=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ii="-";class oi extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag($e.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ve._S||(a=ii);const l=a.split(ve.ot).map(e=>e&&e!==ve._S?e.trim():ii),c=l.map(e=>(0,ge.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),h=c.map(t=>e.measureText(t).width),u=h.reduce((e,t)=>e+t,0);let d=t+(i-u)/2;const p=this.tableCol.getTag(ve.gp.alphabet),m=p===ge.YI.RNA||p===ge.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA;for(let r=0;r<c.length;r++){const a=l[r];let u=Oe.S$,p="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(m,a);u=e?.textcolor??u,p=e?.backgroundcolor??p}else u=this.monomerLib.getMonomerTextColor(m,a);s&&1==l.length&&(e.fillStyle=p,e.fillRect(t,n,i,o)),e.fillStyle=u,e.fillText(c[r],d,n+o/2,i),d+=h[r]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(ve.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),r=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==ve._S||i==ii)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA,c=i.split(ve.ot).map(e=>e&&e!==ve._S&&e!==ii?this.monomerLib.getTooltip(l,e):s.divText("gap")),h=s.divH(c,{style:{alignItems:"top"}}),u=Array.from(h.querySelectorAll("canvas"));if(u.length>2){const e=Math.floor(550/u.length);u.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return s.tooltip.show(h,r,a),!0}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new oi(t,n)),o}}class ri extends a.GridCellRenderer{get name(){return je.uF.MONOMER}get cellType(){return je.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){oi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){oi.getOrCreate(e).onMouseMove(e,t)}}class si{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ai extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class li extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new si(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,we.AP)(e);r.shell.error(t),this.logger.error(t,void 0,n)}}var ci=n(5999),hi={};hi.styleTagTransform=S(),hi.setAttributes=b(),hi.insert=f().bind(null,"head"),hi.domAPI=m(),hi.insertStyleElement=w(),d()(ci.A,hi),ci.A&&ci.A.locals&&ci.A.locals;var ui=n(6307);class di extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=kr.properties.tooltipWebLogo,n=this.seqCol.getTag(Qe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function pi(e,t,n,i){const o=kr.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null===r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const mi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class gi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??mi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${kr.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{kr.handleErrorUI(e)})}).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=s.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{kr.handleErrorUI(e)})});return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var yi=n(8754);async function bi(e,t,n,i,o){const r=await async function(e,t,n,i,o){const r=(0,be.R)(t,o),s=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ve._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return s}(l,r):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,ye.uL)(i,e,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,o);for(let e=0;e<r.length;e++)t.isNone(e)&&r.set(e,null,!1);return r}var vi=n(294),wi=n(330);const Ci=OCL;var Si=n(2582);class Ai{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var xi=n(6956);class Mi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach((t,n)=>{const i=e[n-1];i===xi.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)})}}class Ei{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Ti extends Ei{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class _i{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ii extends _i{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Li extends Ai{constructor(e,t){super(t);const n=Pt.getInstance(e);this.atoms=new Ti(n),this.bonds=new Ii(n),this.rGroups=new Mi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni extends Ei{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class Pi extends _i{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Ri extends Ai{constructor(e,t){super(t);const n=Pt.getInstance(e);this.atoms=new Ni(n),this.bonds=new Pi(n),this.rGroups=new Mi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class $i{static getInstance(e,t){if(Pt.isMolfileV2K(e))return new Li(e,t);if(Pt.isMolfileV3K(e))return new Ri(e,t);throw new Error("Unsupported molfile version")}}class Oi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Pt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=$i.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Oi.molfileV2KToV3KCache.has(e))return Oi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Oi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map(e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,""))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class ki{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Si.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ve.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Oi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new vi.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Ge.o.NUCLEOTIDE:Ge.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(r).take(n.atomCount).toArray(),bonds:R().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END BOND"].join("\n")}}class Hi{constructor(e){this.molfileHandler=Pt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Fi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map(e=>null===e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Ci.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,we.AP)(e);return kr.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),s=`molfile(${e.name})`,l=o?o.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map(e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,wi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=vi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,we.AP)(e);kr.logger.error(t,void 0,n),o=vi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Hi(o),s=new ki(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new vi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new vi.vF(a.molfile,l)}}class Gi{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[Pe.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[Pe.j.notationProvider]??null);const i=this.isFasta()?ve.b9[ge.Hi.FASTA]:this.isSeparator()?ve.b9[ge.Hi.SEPARATOR]:this.isHelm()?ve.b9[ge.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ve.b9[ge.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null===r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=a.Func.find({tags:["notationRefiner"]});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[Pe.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,ke.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,ke.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?Ge.o.NUCLEOTIDE:Ge.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ve.b9[ge.Hi.FASTA]?ve._S:i??ve._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ve._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ve.b9[ge.Hi.FASTA]?ve._S:o??ve._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new Pe.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM||this.notation===ge.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ge.YI.DNA||e===ge.YI.RNA||e===ge.YI.PT}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map(e=>e.trim()):R().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isBiln(){return this.notation===ge.Hi.BILN}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ge.Hi.BILN))return ge.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=o.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let h=o.getTag(ge.gp.alphabet);h||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(h=ge.YI.UN),null!=h&&l.setTag(ge.gp.alphabet,h);let u=o.getTag(ge.gp.alphabetSize);null!=h&&u&&l.setTag(ge.gp.alphabetSize,u);const d=o.getTag(ge.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,u)),e===ge.Hi.BILN&&(l.setTag(ge.gp.separator,"-"),l.meta.units=ge.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!Gi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:ke.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return me.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return me.Z.LEVENSHTEIN}getDistanceFunction(){return me.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ve.b9[ge.Hi.FASTA]:ve.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ge.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(fn.EK,"$1")),n===ve.b9[ge.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ve.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new ke.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},h=this.column.getTag(ge.gp.positionNames);h&&i.setTag(ge.gp.positionNames,c(h));const u=this.column.getTag(ge.gp.positionLabels);return u&&i.setTag(ge.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ge.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Bi(e,n,o.isHelm())};break;case ge.Hi.HELM:{const e=o.alphabet===ge.YI.DNA||o.alphabet===ge.YI.RNA,t=o.getHelmWrappers();i=function(n){return Di(n,t,e)};break}case ge.Hi.BILN:i=function(e){return Vi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ge.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[Pe.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Pe.j.seqHandler]=new Gi(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(fn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.FASTA]:o===fn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Bi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return Di(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ge.Hi.BILN?e:Vi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(fn.EK,"$1"),r=r===fn.q7?null:r),n[e]=r||null}return new ke.Mu(n.filter(e=>!!e),ve.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Bi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(fn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.SEPARATOR]:o===fn.q7&&(r=""),i[t]=r}return i.join(t)}function Di(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,h=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ve._S?r=ve.b9[ge.Hi.HELM]:(n&&(r=r.replace(fn.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),h[t-o]=r}l.push(`${i}${t+1}{${h.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ve._S?s=ve.b9[ge.Hi.HELM]:(n&&(s=s.replace(fn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function Vi(e){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const t=e.graphInfo.disjointSeqStarts,n=new Array(e.length);for(let t=0;t<e.length;++t)n[t]=e.getCanonical(t),n[t]?.includes("-")&&(n[t]=`[${n[t]}]`);for(let i=0;i<e.graphInfo.connections.length;i++){const o=e.graphInfo.connections[i],r=`${i+1}`,s=o.seqIndex1,a=o.seqIndex2,l=t[s]+o.monomerIndex1,c=t[a]+o.monomerIndex2,h=`${n[l]}(${r},${o.rGroup1})`,u=`${n[c]}(${r},${o.rGroup2})`;n[l]=h,n[c]=u}return t.map((i,o)=>{const r=o+1<t.length?t[o+1]:e.length;return n.slice(i,r).join("-")}).join(".")}{const t=new Array(e.length);for(let n=0;n<e.length;++n)t[n]=e.getCanonical(n),t[n]?.includes("-")&&(t[n]=`[${t[n]}]`);return t.join("-")}}class ji{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Gi.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,$t.b2)();return new Fi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return vi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return vi.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return vi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new vi.vF(e,o.monomers)}catch(e){const[t,n]=(0,we.AP)(e);return kr.logger.error(t,void 0,n),vi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),s=e.dataFrame,l=(0,wi.qj)(s,e.name),c=await this.getHelmToMolfileConverter(o),h=e.toList(),u=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n])}if(t&&p){const t=await p.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,Gi.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),Gi.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,Gi.setTags(e)}}async function Wi(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM,ge.Hi.BILN].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await Fr.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[Pe.j.notationProvider]&&(i.temp[Pe.j.notationProvider]=e.cell.column.temp[Pe.j.notationProvider]);const r=(n.getSplitted(e.cell.rowIndex).graphInfo?.connections?.length??0)>0;if(await Fr.toAtomicLevel(o,i,r,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const s=o.columns.byIndex(1).get(0);return s?{errorText:"",mol:s}:(t="No structure generated",{errorText:t,mol:""})}catch(e){kr.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Ui="#333333",qi="rgba(60, 177, 115, 0.1)",zi="rgba(240, 240, 240, 0.5)",Yi="rgba(100, 100, 100, 0.3)";class Ki{constructor(e=Ji.DEFAULT_TRACK_HEIGHT,t=Ji.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class Zi extends Ki{constructor(e=new Map,t=Ji.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,Ji.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Ge.o.NUCLEOTIDE;break;default:t=Ge.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,ui.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(s.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(s.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(s.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=t+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,e,t,n,i,o,r,s,a,h,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,h){const u=r+e-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=t+e*s,m=s-2;r+e===l&&(this.ctx.fillStyle=qi,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=zi,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,u),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class Xi extends Ki{constructor(e,t=Ji.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,Ji.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,t,i),l===a&&(this.ctx.fillStyle=qi,this.ctx.fillRect(c,t,h,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=zi,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Ui,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Ji={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Qi={BASE:Ji.DOTTED_CELL_HEIGHT+Ji.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Ji.TITLE_HEIGHT+Ji.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Ji.DEFAULT_TRACK_HEIGHT+Ji.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Ji.DEFAULT_TRACK_HEIGHT+Ji.TRACK_GAP}};class eo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||Qi.BASE,sliderHeight:e.sliderHeight||Ji.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(Ji.DEFAULT_TRACK_HEIGHT)}),!(e<Qi.WITH_TITLE()||e<Qi.WITH_WEBLOGO()))if(e<Qi.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-Qi.WITH_WEBLOGO();t.setHeight(Ji.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>Qi.WITH_BOTH()){const n=e-Qi.WITH_BOTH();t.setHeight(Ji.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<Qi.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<Qi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Qi.WITH_TITLE()?(Ji.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=Qi.WITH_WEBLOGO();else{if("conservation"!==e)return;t=Qi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?Qi.WITH_BOTH():Qi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=Qi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,Ji.TITLE_HEIGHT),this.ctx.fillStyle=Ui,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+Ji.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof Zi&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0,l=this.config.headerHeight-Ji.SLIDER_HEIGHT-Ji.DOTTED_CELL_HEIGHT,c=l-Ji.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){h=e,u=n-i;break}g=i-Ji.TRACK_GAP}let f=null;if(h){const e=this.tracks.get(h);e&&(f=e.getMonomerAt(t,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=f,h)){const e=this.tracks.get(h);e instanceof Zi&&(e.setHovered(r,f),window.requestAnimationFrame(()=>this.redraw()))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=f,h)){const t=this.tracks.get(h);if(t){const n=t.getTooltipContent(r,f);if(n)return void s.tooltip.show(n,e.clientX+16,e.clientY+16)}}h&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Qi.WITH_TITLE();l&&Ji.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Ji.SLIDER_HEIGHT,h=c-Ji.DOTTED_CELL_HEIGHT,u=h-Ji.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const g=this.getTrack("conservation");g&&g.isVisible()&&p.push({id:"conservation",track:g});let f=u;for(const{track:e}of p){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-Ji.TRACK_GAP}if(this.drawDottedCells(0,h,n,Ji.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:Ji.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=t+Ji.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=e+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,t),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Ui,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,Ji.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,Ji.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,Ji.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-Ji.SLIDER_HEIGHT;return t>n&&t<n+Ji.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-Ji.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Ji.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0,a=this.config.headerHeight-Ji.SLIDER_HEIGHT-Ji.DOTTED_CELL_HEIGHT,l=a-Ji.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of u){const i=m-t.getHeight();if(n>=i&&n<m){c=e,h=n-i;break}m=i-Ji.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Qi.WITH_TITLE()&&t&&(to(e.left??0,n,i)||to(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-Ji.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Qi.BASE,WITH_TITLE:Qi.WITH_TITLE(),WITH_WEBLOGO:Qi.WITH_WEBLOGO(),WITH_BOTH:Qi.WITH_BOTH()}}}function to(e,t,n){return e>=t&&e<=n}class no{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){no.conservationCache=new a.LruCache(100),no.webLogoCache=new a.LruCache(100),no.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return no.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return no.conservationCache.getOrCreate(i,()=>{const o=no.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return no.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/no.CHUNK_SIZE)*no.CHUNK_SIZE,s=Math.ceil(n/no.CHUNK_SIZE)*no.CHUNK_SIZE;for(let t=r;t<s;t+=no.CHUNK_SIZE){const n=Math.min(t+no.CHUNK_SIZE,i),r=no.getChunkCacheKey(e.column,t,n),s=no.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/no.CHUNK_SIZE)*no.CHUNK_SIZE,s=Math.ceil(n/no.CHUNK_SIZE)*no.CHUNK_SIZE;for(let t=r;t<s;t+=no.CHUNK_SIZE){const n=Math.min(t+no.CHUNK_SIZE,i),r=no.getChunkCacheKey(e.column,t,n),s=no.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class io extends Zi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=no.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=no.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class oo extends Xi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=no.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=no.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class ro{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}constructor(e,t,n){this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=ke.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ve.Hi.HELM})(n)}createCellRendererBack(e,t){const n=kr.properties.maxMonomerLength||4,i=new so(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class so extends Oe.Jy{constructor(e,t,n,i){super(e,t,kr.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Oe.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:ke.zS}})}}async function ao(){return await Fr.getMonomerLibHelper()}async function lo(){await Fr.initBio()}function co(e){return Fr.sequenceTooltip(e)}async function ho(e){return await Fr.standardiseMonomerLibrary(e)}async function uo(e,t,n){await Fr.matchWithMonomerLibrary(e,t,n)}function po(){return Fr.getBioLib()}function mo(e){return Fr.getSeqHandler(e)}function go(e){return Fr.getRegionPanel(e)}async function fo(e){return await Fr.libraryPanel(e)}function yo(e){Fr.GetRegionEditor(e)}function bo(e){Fr.SplitToMonomersEditor(e)}function vo(e){Fr.SequenceSpaceEditor(e)}function wo(e){Fr.SeqActivityCliffsEditor(e)}function Co(){return Fr.customSequenceCellRenderer()}function So(){return Fr.fastaSequenceCellRenderer()}function Ao(){return Fr.separatorSequenceCellRenderer()}function xo(){return Fr.bilnSequenceCellRenderer()}function Mo(e,t,n){return Fr.refineNotationProviderForBiln(e,t,n)}function Eo(e){return Fr.macroMolColumnPropertyPanel(e)}function To(e){return Fr.compositionAnalysisWidget(e)}function _o(){return Fr.macromoleculeDifferenceCellRenderer()}function Io(e,t,n,i,o){return Fr.sequenceAlignment(e,t,n,i,o)}function Lo(){return Fr.webLogoViewer()}function No(){return Fr.vdRegionsViewer()}function Po(e,t,n,i){return Fr.getRegion(e,t,n,i)}async function Ro(e,t,n,i,o){await Fr.getRegionTopMenu(e,t,n,i,o)}async function $o(e,t,n,i,o,r,s,a,l){return await Fr.activityCliffs(e,t,n,i,o,r,s,a,l)}async function Oo(e,t,n,i,o){return await Fr.macromoleculePreprocessingFunction(e,t,n,i,o)}async function ko(e,t){return await Fr.helmPreprocessingFunction(e,t)}async function Ho(e,t,n,i,o,r,s,a,l){return await Fr.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function Fo(e,t,n,i){await Fr.toAtomicLevel(e,t,n,i)}async function Go(e){await Fr.toAtomicLevelAction(e)}async function Bo(e){return await Fr.toAtomicLevelPanel(e)}async function Do(e){return await Fr.sequence3dStructureWidget(e)}function Vo(){Fr.multipleSequenceAlignmentDialog()}async function jo(e,t,n){return await Fr.alignSequences(e,t,n)}async function Wo(){return await Fr.compositionAnalysis()}function Uo(e){return Fr.importFasta(e)}function qo(e){return Fr.importBam(e)}function zo(){Fr.convertDialog()}function Yo(e){Fr.convertColumnAction(e)}function Ko(){return Fr.monomerCellRenderer()}async function Zo(e){return await Fr.testDetectMacromolecule(e)}async function Xo(e,t){return await Fr.splitToMonomersTopMenu(e,t)}function Jo(e){return Fr.getHelmMonomers(e)}function Qo(){return Fr.similaritySearchViewer()}function er(){return Fr.similaritySearchTopMenu()}function tr(){return Fr.diversitySearchViewer()}function nr(){return Fr.diversitySearchTopMenu()}function ir(e){Fr.searchSubsequenceEditor(e)}function or(e){Fr.SubsequenceSearchTopMenu(e)}async function rr(e,t,n){return await Fr.sequenceIdentityScoring(e,t,n)}async function sr(e,t,n){return await Fr.sequenceSimilarityScoring(e,t,n)}async function ar(){await Fr.manageMonomerLibraries()}async function lr(){await Fr.manageLibrariesView()}async function cr(){await Fr.manageMonomersView()}async function hr(){return await Fr.manageMonomerLibrariesView()}async function ur(e){await Fr.manageMonomerLibrariesViewTreeBrowser(e)}function dr(){Fr.saveAsFasta()}function pr(){return Fr.bioSubstructureFilter()}function mr(){return Fr.bioSubstructureFilterTest()}async function gr(){await Fr.webLogoLargeApp()}async function fr(){await Fr.webLogoAggApp()}async function yr(){await Fr.getRegionApp()}async function br(){await Fr.getRegionHelmApp()}function vr(){Fr.longSeqTableSeparator()}function wr(){Fr.longSeqTableFasta()}function Cr(){Fr.longSeqTableHelm()}function Sr(e,t){Fr.addCopyMenu(e,t)}async function Ar(){await Fr.demoBioSimilarityDiversity()}async function xr(){await Fr.demoBioSequenceSpace()}async function Mr(){await Fr.demoBioActivityCliffs()}async function Er(){await Fr.demoBioAtomicLevel()}async function Tr(e){await Fr.sdfToJsonLib(e)}async function _r(e,t){return await Fr.seq2atomic(e,t)}async function Ir(e,t){return await Fr.seqIdentity(e,t)}async function Lr(e,t,n){await Fr.detectMacromoleculeProbe(e,t,n)}async function Nr(){return await Fr.getSeqHelper()}async function Pr(e,t,n){return await Fr.getMolFromHelm(e,t,n)}var Rr=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},$r=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Or=function(e,t){return function(n,i){t(n,i,e)}};const kr=new li;let Hr=null;r.decorators||(r.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{r.decorators[e]||(r.decorators[e]=function(e){return function(e,t,n){}})});class Fr{static async getMonomerLibHelper(){return await un.getInstance()}static async initBio(){null===Hr&&(Hr=async function(){const e="Bio: _package.initBio()";kr.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Ne.j)(),i=await kr.getProperties(),o=new ai(i);kr.properties=o;const s=await un.getInstance(),l=await(0,Le.ub)();l.explicit&&(l.explicit=[],await(0,Le.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();kr.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new ji(s,n);kr.completeInit(p,c,u,n),kr.logger.debug(`${e}, end`),function(){const e=e=>{setTimeout(()=>{if(e.isDetached)return;const t=e.dataFrame;if(!t)return;const n=t.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=kr.seqHelper.getSeqHandler(i)}catch(e){continue}if(!n)continue;if(n.isHelm()||n.alphabet===ge.YI.UN)continue;const o=e.col(i.name);if(!o)continue;let s=!!e.tableView&&Array.from(e.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);if(n.isMsa()){const l=(e,t)=>Number.isNaN(e)?t:e,c=()=>l(Math.max(Number.parseInt(i.getTag(ge.gp.positionShift)??"0"),0),0)+1,u=()=>l(Number.parseInt(i.getTag(ge.gp.selectedPosition)??"-2"),-2),d=()=>Oe.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const g=i.categories;for(let e=0;e<g.length;e++){const t=g[e];t&&t.length>m&&(m=t.length,p=e)}const f=g[p],y=n.splitter(f),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=i.length>1e5||b<50?v.WITH_TITLE:i.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,S=null;const A=a.debounce(h.merge(t.onFilterChanged,t.onDataChanged.pipe((0,k.filter)(e=>e?.args?.column===i))),100).subscribe(()=>{no.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),S&&(S.resetViewportTracking(),S.forceUpdate()),setTimeout(()=>{e.isDetached||e.invalidate()},50)});e.sub(A);const x=r=>{const l=[],h=new oo(n,b,45,"default","Conservation");S=h,l.push({id:"conservation",track:h,priority:1});const p=new io(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new eo({canvas:e.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(t,n)=>{setTimeout(()=>{const o=c(),r=u();if(o!==n.start&&i.setTag(ge.gp.positionShift,(n.start-1).toString()),r!==t&&(i.setTag(ge.gp.selectedPosition,t.toString()),t>=0&&!s&&e.tableView&&R()(e.dataFrame?.columns.numerical).find(e=>!0))){s=!0;const t=e.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});e.tableView.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:t=>{e.isDetached||t<v.WITH_TITLE||setTimeout(()=>e.props.colHeaderHeight=t)}},o);m.setupTooltipHandling(),l.forEach(({id:e,track:t})=>{m.addTrack(e,t)}),m.setSelectionData(t,i,n),b>50&&(e.props.colHeaderHeight=w,setTimeout(()=>{e.isDetached||(o.width=400)},300)),e.sub(e.onCellRender.subscribe(e=>{const t=e.cell;if(!t||!t.isColHeader||t?.gridColumn?.name!==o?.name)return;const n=e.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,u(),s,e,i.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();x(t)}).catch(e=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}}},1e3)},t=(r.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)}),r.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Hr}static sequenceTooltip(e){const t=new di(e,kr.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();r.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Mn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const o=a.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!o)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const r=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),s=(await Mn(r)).map((e,t)=>({sym:e.symbol,smiles:kn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:r[t]?.lib?.source})).filter(e=>!!e?.smiles&&!e.smiles.includes("[*:")),l=a.Column.fromList(a.COLUMN_TYPE.STRING,"MonomerSmiles",s.map(e=>e.smiles));l.semType=a.SEMTYPE.MOLECULE;const c=await o.apply({molecule:l,targetNotation:a.chem.Notation.Smiles});if(!c||c.length!==l.length)throw new Error("Error canonicalizing monomer smiles");c.toList().forEach((e,t)=>s[t].smiles=e);const h=e.col(t),u=await o.apply({molecule:h,targetNotation:a.chem.Notation.Smiles});if(!u||u.length!==h.length)throw new Error("Error canonicalizing molecules");const d=u.toList(),p=e.clone(),m=p.columns.addNewString(p.columns.getUnusedName("Matched monomer smiles"));m.semType=a.SEMTYPE.MOLECULE;const g=p.columns.addNewString(p.columns.getUnusedName("Matched monomer symbol"));g.semType="Monomer";const f=p.columns.addNewString(p.columns.getUnusedName("Matched monomer source"));p.columns.setOrder([t,g.name,m.name,f.name]);for(let e=0;e<d.length;e++){const t=d[e];if(t)for(let n=0;n<s.length;n++)if(s[n].smiles===t){m.set(e,s[n].original,!1),g.set(e,s[n].sym,!1),f.set(e,s[n].source??"",!1);break}}return p}(e,t.name,kr.monomerLib,n);r.shell.addTableView(i)}static getBioLib(){return kr.monomerLib}static getSeqHandler(e){return kr.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:kr.name,name:t});if(1!==n.length)throw new Error(`Package '${kr.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new fi(i,kr.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=s.label("Manage monomer libraries");return pn()(e).addClass("d4-link-action"),e.onclick=async()=>await Vn(),new a.Widget(e)}()}static GetRegionEditor(e){try{new fi(e,kr.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(`Get region editor error: ${t}`),kr.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ti;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Se({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new qe}static fastaSequenceCellRenderer(){return new qe}static separatorSequenceCellRenderer(){return new qe}static bilnSequenceCellRenderer(){return new qe}static refineNotationProviderForBiln(e,t,n){return"-"===n&&(!(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))&&!Object.keys(t.freq).some(e=>e.includes("[")||e.includes("]")))&&(e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ge.Hi.BILN,e.temp[Pe.j.notationProvider]=new ro(n,kr.seqHelper,e),!0))}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===a.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=kr.properties?kr.properties.maxMonomerLength:4;if($e.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag($e.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=kr.properties?kr.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==ge.Hi.HELM&&(d=s.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,h,c,u];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ge.gp.alphabet],r=o===ge.YI.DNA||o===ge.YI.RNA?Ge.o.NUCLEOTIDE:Ge.o.AA,l={},c=n.getSeqHandler(e.cell.column),h=e.cell.rowIndex,u=c.getSplitted(h);R().count(0).take(u.length).filter(e=>!u.isGap(e)).forEach(e=>{let t=u.getCanonical(e);r===Ge.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;l[t]=n+1});const d=(0,ui.F)(l,r,t);return Array.from(d.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(d),new a.Widget(i)}(e,kr.monomerLib,kr.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ye}static sequenceAlignment(e,t,n,i,o){const r=new ht(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new nt.oP}static vdRegionsViewer(){return new at}static getRegion(e,t,n,i){return pi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const s=pi(t,n??null,i??null,o??null);t.dataFrame.columns.add(s),await r.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,h,u,d,p){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);if(!(0,Xn.V)(t,"Activity Cliffs"))return;const m=Ee(e),g={units:t.meta.units,aligned:t.getTag(ge.gp.aligned),separator:t.getTag(ge.gp.separator),alphabet:t.getTag(ge.gp.alphabet)},f=h,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,f,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,g,u,pt,mt,bt,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),S=await new Promise((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return S?.props?.xColumnName&&S?.props?.yColumnName&&e.col(S.props.xColumnName)&&e.col(S.props.yColumnName)&&(e.col(S.props.xColumnName).set(0,e.col(S.props.xColumnName).get(0)),e.col(S.props.yColumnName).set(0,e.col(S.props.yColumnName).get(0))),S}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:s}=await ut(e,t,o,n,i);return{entries:r,options:s}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,dt.BQ)(e,kr.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=W.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,s,c,h,u){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);const d=r.shell.tv.dataFrame==e?r.shell.tv:void 0;return(0,Xn.V)(t,"Sequence Space")?(s||(s=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await _e(e,[t],n,[i],[1],[s],"MANHATTAN",o,h??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Hr;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??kr.monomerLib,r=kr.seqHelper,s=kr.rdKitModule;await(0,yi.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Wi(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(s.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(t.mol,e,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){kr.logger.error(e)}return a.Widget.fromRoot(s.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Wi(e);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=Ci.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=s.div([t],{style:{aspectRatio:"1"}})}catch(e){n=s.divText("Couldn't get 3D structure")}}catch(e){n=s.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,Qn.D)({},kr.seqHelper).catch(e=>{const[t,n]=(0,we.AP)(e);if(e instanceof Jn.Ap)return r.shell.warning(e.element),void kr.logger.warning(t);r.shell.error(t),kr.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,Qn.D)({col:e,clustersCol:t,...n},kr.seqHelper)}static async compositionAnalysis(){const e=r.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(kr.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,Xn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>kr.seqHelper.getSeqHandler(e).isMsa()),o=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}static importFasta(e){return new fe.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Re.me)()[0];(0,Mt.C)(e,kr.seqHelper)}static convertColumnAction(e){(0,Mt.C)(e,kr.seqHelper)}static monomerCellRenderer(){return new ri}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const o=[];for(const s of n)try{const t=await r.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${e}`,s}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Je.cb)(10),!(0,Xn.V)(t,"Sequence space"))return e;const n=kr.seqHelper,i=(0,be.R)(t,n);i.name="splitToMonomers";const o=t.dataFrame;for(const e of i.columns)e.semType=je.uF.MONOMER,e.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=e=>{s.lastIndex=0;const t=e.match(s);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=je.uF.MONOMER,n.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return o}(e,t)}static getHelmMonomers(e){return kr.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new St(kr.seqHelper)}static similaritySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new At(kr.seqHelper)}static diversitySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Re.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new dt.a7(t,kr.seqHelper)}static SubsequenceSearchTopMenu(e){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),r.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=kr.seqHelper;return bi(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=kr.seqHelper;return bi(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Vn()}static async manageLibrariesView(){await jn()}static async manageMonomersView(){const e=await Tn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await jn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await un.getInstance()).getFileManager()).getValidLibraryPaths().forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await Tn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,Et.TE)()}static bioSubstructureFilter(){return new Tt._i(kr.seqHelper,kr.logger)}static bioSubstructureFilterTest(){return new Tt._i(kr.seqHelper,kr.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new ei(e,"webLogoLargeApp"),n=await kr.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new ei(e,"webLogoAggApp"),n=await kr.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await kr.files.readCsv("samples/HELM_empty_vals.csv"),n=new gi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,Ie.dW)());r.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(kr.seqHelper,ge.Hi.FASTA)]);r.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(kr.seqHelper,ge.Hi.HELM)]);r.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ge.Hi).filter(e=>e!==ge.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,o=e.rowIndex,s=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?kr.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${t}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,kr.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await kr.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=r.shell.addTableView(e);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Re.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await r.functions.eval("Bio:SeqSpaceDemo"),t=await r.dapi.projects.find(e.id);await t.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await kr.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=r.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Fr.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,me.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),pn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===a.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(t),kr.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await kr.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const t=r.shell.addTableView(e),n=e.col("HELM");await Fr.toAtomicLevel(e,n,!0,!1),(0,Re.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Re.Kd)(t.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}static async sdfToJsonLib(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await Fr.getMonomerLibHelper()).getMonomerLib(),l=kr.seqHelper,c=await(0,Ne.j)(),h=(await(0,yi.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(e){const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await bi(i,n,t,pe.IDENTITY,kr.seqHelper)).get(0)}catch(e){const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(e),u=t?h.getCol(t):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Je.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Fr.initBio(),kr.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=kr.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,kr.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,t,n,kr.monomerLib)}}Rr([r.decorators.func({description:"Returns an instance of the monomer library 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e=Date.now()-n.start;n.start=r.now()-e}this.set(t,n.value,n)}}set(e,t,n={}){if(void 0===t)return this.delete(e),this;const{ttl:i=this.ttl,start:o,noDisposeOnSet:r=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#H(e,t,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#R(e,"set"),this;let h=0===this.#a?void 0:this.#c.get(e);if(void 0===h)h=0===this.#a?this.#g:0!==this.#f.length?this.#f.pop():this.#a===this.#t?this.#G(!1):this.#a,this.#h[h]=e,this.#u[h]=t,this.#c.set(e,h),this.#d[this.#g]=h,this.#p[h]=this.#g,this.#g=h,this.#a++,this.#F(h,c,a),a&&(a.set="add"),l=!1;else{this.#E(h);const n=this.#u[h];if(t!==n){if(this.#S&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:t}=n;void 0===t||r||(this.#C&&this.#i?.(t,e,"set"),this.#A&&this.#y?.push([t,e,"set"]))}else r||(this.#C&&this.#i?.(n,e,"set"),this.#A&&this.#y?.push([n,e,"set"]));if(this.#k(h),this.#F(h,c,a),this.#u[h]=t,a){a.set="replace";const e=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==e&&(a.oldValue=e)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(h,i,o),a&&this.#O(a,h)),!r&&this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}return this}pop(){try{for(;this.#a;){const e=this.#u[this.#m];if(this.#G(!0),this.#x(e)){if(e.__staleWhileFetching)return e.__staleWhileFetching}else if(void 0!==e)return e}}finally{if(this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}}}#G(e){const t=this.#m,n=this.#h[t],i=this.#u[t];return this.#S&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#A)&&(this.#C&&this.#i?.(i,n,"evict"),this.#A&&this.#y?.push([i,n,"evict"])),this.#k(t),e&&(this.#h[t]=void 0,this.#u[t]=void 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s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,o.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...e};Object.entries(s).forEach(([e,n])=>t[e.charCodeAt(0)]=n);const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,r)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,h=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let u=1;u<r.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<e.length+1;d++){const 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i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),g=n(5553),f=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,r){if(super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe(()=>{this._onRendered.next()})),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe(()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(t=>t.args.source===this.tableCol&&e.includes(t.args.key))),200).subscribe(e=>{this.reset()})),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift)),200).subscribe(e=>{this.reset()}))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,r){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const h=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,g=Math.max(0,Math.floor(m/s)),f=[];let y=0;for(let e=0;e<g&&y<h.length;e++){const t=[];for(let e=0;e<p&&y<h.length;e++){const n=h[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}f.push({lineIdx:e,elements:t})}return{lineLayouts:f,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,h.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe(()=>{this.reset()})),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return 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t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(t/i)+o,s=n.splitter(e),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=s.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,r=n.getSplitted(e),s=Math.min(o,r.length);let a=this._monomerLengthList[e];if(null===a||a.length!=s-t){a=this._monomerLengthList[e]=new Array(r.length);let i=0;for(let e=t;e<s;++e){const 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach(t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])}),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){r.shell.error("Error applying input from history"),console.error(e)}}}var k=n(9713),H=n(6295);const F=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex(e=>n<e);e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class B{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(793),n.b))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],r=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||r.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise(async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),f=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),p=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout(()=>this._workers[n].terminate()),o?t(o):(u.set(r,i),s<m&&(m=s),a>g&&(g=a),e())}})}await Promise.all(l),n&&u.forEach((e,t)=>{u[t]=(e-m)/(g-m)}),i(u)}catch(e){a(e)}})}terminate(){this._workers.forEach(e=>e.terminate())}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,r=e.distance;for(let e=0;e<o;e++)i[Math.floor(r[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)r[e]<m&&(l[p]=u[e],c[p]=d[e],h[p]=r[e],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(e,t,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach((e,t)=>r[t].threshold=o);const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(111),n.b)));for(let n=0;n<this._workerCount;n++)u[n]=new Promise((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:u,endIdx:p,threshold:o,fnNames:t,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:r}})=>{e?(d[n].terminate(),h(e)):(d[n].terminate(),i({i:t,j:o,distance:r,idx:n}))}});const p=await Promise.all(u),m=p.reduce((e,t)=>e+t.i.length,0),g=new Int32Array(m),f=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(603),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t])),knnIndexes:new Array(e[0].length).fill(null).map((e,t)=>new Array(p[t]))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,r=15,s,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(810),n.b))),h=new Array(this._workerCount),u=e[0].length,d=e.map(e=>e[t]),p=Math.ceil(u/this._workerCount);for(let t=0;t<this._workerCount;t++)h[t]=new Promise((n,i)=>{const h=t*p,m=t===this._workerCount-1?u:(t+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map(e=>e.slice(h,m)),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:r}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:r}))}});const m=await Promise.all(h),g={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,r,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==r.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some(t=>t.length!==e[0].length))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(950),n.b)));for(let n=0;n<this._workerCount;n++)h[n]=new Promise((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:o}))}});const d=await Promise.all(h),p={knnDistances:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(99999)),knnIndexes:new Array(e[0].length).fill(null).map(()=>new Array(o).fill(-1))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map(()=>new Worker(new URL(n.p+n.u(778),n.b)));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:h,fnNames:t,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}});const d=await Promise.all(u),p=d.reduce((e,t)=>e+t.distance.length,0),m=new Float32Array(p);let g=0;for(const e of d)m.set(e.distance,g),g+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach(e=>e?.terminate()),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,r=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=F(e[l])||F(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),r.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,j,W=n(8774);(j=V||(V={})).none="none",j.bold="bold",j.dashed="dashed";class U{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new W.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe(e=>{this.renderLines()})}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,r,s,a,l,c,h,u,d,p,m,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const S=this.sp.pointToScreen(this.lines.to[e]);let A=null==S?void 0:S.x,x=null==S?void 0:S.y;const M=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&A&&x&&Math.hypot(A-w,x-C)/M>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[e])?null===(u=this.lines.widths)||void 0===u?void 0:u[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let S=null;if(b){t=this.getLineLength(w,C,A,x);const o=this.getPointOnDistance(w,C,A,x,i,t),r=this.getPointOnDistance(A,x,w,C,n,t);w=o.x,C=o.y,A=r.x,x=r.y,S=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,A,x,e):this.findControlPoint(b,A,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(S.x,S.y,A,x)}else(!this.lines.skipShortLines||Math.pow(A-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(A,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,A,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,A,x,i,t),n=b?S.x:w,o=b?S.y:C;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:w,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,e,t,i,h,u)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=r+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,h=c-l;return this.calculateDistToCurveInRect(t,n,i,r,o,e,h)}return null}calculateDistToCurveInRect(e,t,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new W.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(e-a),g=Math.abs(t-p),f=m+g;(!d||d>f)&&(d=f),u[r]=Math.max(m,g),c[r]=a,h[r]=p}for(let e=0;e<c.length;e++)u[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,h[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,r){const s=n-o*((n-e)/r),l=i-o*((i-t)/r);return new a.Point(s,l)}findControlPoint(e,t,n,i,o,r){const s=t+(i-t)/2,l=n+(o-n)/2;let c=s-t,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(e,t,n,i,o){const r=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}const q="dimensionality-reducer-terminate-event";var z,Y,K=n(3629);async function Z(e,t,i,o,s,a,l){let c=await async function(e,t,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise(function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q).subscribe(()=>{try{u?.terminate()}finally{d.unsubscribe()}});u.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{F(n)||F(i)?(d.unsubscribe(),e?h(e):c(t),setTimeout(()=>u.terminate(),100)):l&&l(n,i,t)}})}(e,i,t,o,s,a,l);return c=c.map(e=>(0,K.S8)(e)),c}(Y=z||(z={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const X={[z.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[z.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,r){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){const s=yield function(){return M(this,void 0,void 0,function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!E&&(E=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==E))return null;let e=!1;if(T&&(T.lost.then(()=>{e=!0}),yield new Promise(e=>setTimeout(e,10))),!T||e){const e=1e9,t=E.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return T=yield E.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),T}catch(e){return console.error("Failed to create device 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Please provide at least one column of data.");1===c&&(i=z.MANHATTAN);let d=u.map(e=>e.suppInfoStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map(e=>e.dataStructWgsl).filter(e=>!!e&&""!=e).join(",\n"),g=new Uint32Array(c*h);u.forEach((e,t)=>{g.set(e.arraySizes,t*h)});const f=1e4,y=100,b=u.reduce((e,t)=>e+t.complexity,0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,S=h*(h-1)/2,A=Math.ceil(S/f),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${A} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    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let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,u.map(e=>e.maxEntryLen),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(f),L=new Uint32Array(f),N=new Uint32Array(f),P=new Uint32Array(f),R=Math.floor(S/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?S-1:(e+1)*R,n=h-2-Math.floor(Math.sqrt(-8*t+4*h*(h-1)-7)/2-.5),i=t-h*n+Math.floor((n+1)*(n+2)/2);I[e]=O,L[e]=$,N[e]=i,P[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce((e,t)=>e+t.sourceArraySize,0),H=u.reduce((e,t)=>e+t.suppInfoSize,0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const D=15&G;0!==D&&(B+=16-D);const 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pe,me=n(6863),ge=n(2003),fe=n(3516),ye=n(6718),be=n(3077),ve=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var we=n(9192);class Ce{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Se extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ce}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach(e=>this.activitiesInputRoot.append(e))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Ae,xe,Me;function Ee(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter(e=>e.includes(t[0])).length+1;return t.map(e=>`${e}_${n}`)}function Te(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map(e=>e.name).join(", ")})`}async function _e(e,t,i,o,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},g={},f=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==h.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?g.tableView??r.shell.tableView(e.name)??r.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let S;try{const A=Ee(e);function x(n,o,r){let c=null,h=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),h=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),h=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!S&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}))),g[l.YP]&&(S?.root&&s.setUpdateIndicator(S.root,!1),c.init(e=>r[0]?r[0][e]:void 0),h.init(e=>r[1]?r[1][e]:void 0));const u=n/o*100;C.update(u,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function M(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(S=w.scatterPlot({...v,x:A[0],y:A[1],title:g.scatterPlotName??Te(t,i)}),s.setUpdateIndicator(S.root,!0));const p=r.events.onViewerClosed.subscribe(e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&S?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===S?.getOptions()?.look?.title&&(r.events.fireCustomEvent(q,{}),p.unsubscribe(),n?.(),C.close())}),f=new Promise(async(r,s)=>{try{n=r;const s=[];let a=o,d=c,p=u;if(b&&t.every(e=>e.isNumerical)){const n=t.map(e=>e.toList()),i=new Array(e.rowCount).fill(0).map((e,n)=>new Float32Array(t.length));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<h.length;++e){const n=h[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,r=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[r]:o[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}r(await Z(s.map(e=>e.entries),i,a,d,u,m,g[l.vb]?void 0:x))}catch(e){s(e)}}),y=await f;return C.close(),p.unsubscribe(),y}const E=await M();if(p&&E){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})}(this,void 0,void 0,function*(){return new Promise(function(r,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):r(t)}})})}(E[0],E[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init(e=>_[e].toString()),S&&(S.props.colorColumnName=I)}catch(L){r.shell.error("Clustering embeddings failed"),console.error(L)}finally{T.close()}}if(E){const N=e.columns.byName(A[0]),P=e.columns.byName(A[1]);if(N.init(e=>E[0][e]),P.init(e=>E[1][e]),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:N,[$]:P,...y}).call(!0)}catch(O){r.shell.error("Post-processing failed"),console.error(O)}if(S)return s.setUpdateIndicator(S.root,!1),S.helpUrl="/help/compute/sequence-space",S}}catch(k){r.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),S&&s.setUpdateIndicator(S.root,!1)}};return new Promise(async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK(async()=>{try{const e=await C();t(e)}catch(e){n(e)}}).onCancel(()=>t(void 0)).show();else{const e=await C();t(e)}}catch(e){n(e)}})}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ae||(Ae={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(xe||(xe={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Me||(Me={})),Object.prototype.toString;var Ie=n(6873),Le=n(4356),Ne=n(6717),Pe=n(4025),Re=n(4870),$e=n(3856),Oe=n(6882),ke=n(7278),He=n(5553),Fe=n(6642),Ge=n(3599),Be=n(673),De=n(8312);class Ve extends Fe.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,kr.logger),(0,ye.pj)().then(e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe(()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()}))}),(0,De.Q)().then(e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()})}}var je=n(4139);const We=ge.zS;function Ue(e){const t=!R().enumerate(e).some(([t,n])=>t.length>1&&0!=n&&n!=e.length-1),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let r=t;o<e.length&&(r+=`${t?"":"-"}${i}`),n.push(r)}return[n,t]}class qe extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=kr.seqHelper}getRendererBack(e){const[t,n,i]=(0,Fe.BG)(e);if(i.rendererBack)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate();const n=this.getRendererBack(e);n?.onClick(e,t)}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,He.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe(e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()})}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,r,s){const[a,l,c]=(0,Fe.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(kr.properties?kr.properties.maxMonomerLength:4)??50;if($e.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag($e.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new Oe.Jy(a,l,kr.logger,d,()=>{const{font:e,fontWidth:t}=Oe.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:u.isMsa()?8:0,monomerToShort:We}}),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,p.init().then(()=>{})),p.render(e,t,n,i,o,r,s)}render(e,t,n,i,o,r,s){const a=this.getRendererBack(r);a?a?.render(e,t,n,i,o,r,s):this.renderInt(e,t,n,i,o,r,s)}}class ze extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[ge.gp.separator],u=this.tableCol.meta.units;i=(0,Oe.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Pe.j.notationProvider]?.separatorSplitter??(0,ke.Iv)(u,h),g=m(d),f=m(p),y=R().count(0).take(g.length).map(e=>g.getCanonical(e)).toArray(),b=R().count(0).take(f.length).map(e=>f.getCanonical(e)).toArray(),v=this.tableCol.getTag(ge.gp.alphabet);Ke(e,t,n,i,o,y,b,v===ge.YI.RNA||v===ge.YI.DNA?Ge.o.NUCLEOTIDE:Ge.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ze(t,n)),o}}class Ye extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return je.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,r,s){ze.getOrCreate(r).render(e,t,n,i,o,r,s)}}function Ke(e,t,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,r=e.length>t.length?t:e;for(let e=0;e<r.length;e++)o[e]===r[e]&&n++;const s=o.length-r.length;for(let e=o.length-1;e>s;e--)o[e]===r[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(ve.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(r,s);r=e.subParts1,s=e.subParts2}const u=e.measureText(Ue(r).join("")),d=e.measureText(Ue(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,e.canvas.width=p+4*r.length);let m=Math.max(t,t+(i-(p+4*r.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*r.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const u=7;for(let t=0;t<r.length;t++){const n=r[t],c=s[t];let d=Oe.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=Oe.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,$e.oZ)(e,n,m,g-u,i,o,{color:d,pivot:0,left:!0}),p=(0,$e.oZ)(e,c,m,g+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[t]=Ze(n,c,d,r,g,u,o))}else m=(0,$e.oZ)(e,n,m,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Ze(e,t,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ue([e]).join("")).width,h=l.measureText(Ue([t]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,$e.oZ)(l,e,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,$e.oZ)(l,t,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Xe,Je=n(8070),Qe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Xe||(Xe={}));const et=new class{constructor(){this.regionTypes=[Xe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Qe.fH.Entropy,this.filterSource=Qe.Fo.filterSource}};var tt=n(7602),nt=n(250);const it=Xe;var ot,rt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(ot||(ot={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(rt||(rt={}));const st=et;class at extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(rt.skipEmptyPositions,st.skipEmptyPositions,{category:ot.DATA}),this.regionTypes=this.stringList(rt.regionTypes,st.regionTypes,{category:ot.DATA,choices:Object.values(it).filter(e=>e!=it.Unknown)}),this.chains=this.stringList(rt.chains,st.chains,{category:ot.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(rt.fitWidth,st.fitWidth,{category:ot.LAYOUT}),this.positionWidth=this.float(rt.positionWidth,st.positionWidth,{category:ot.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(rt.positionHeight,st.positionHeight,{category:ot.LAYOUT,choices:Object.keys(Qe.fH)}),this.filterSource=this.string(rt.filterSource,st.filterSource,{category:ot.BEHAVIOR,choices:Object.values(Qe.lT)}),this.viewSyncer=new tt.g(kr.logger)}static viewerCounter=-1;viewerId=++at.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())})}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case rt.regionTypes:case rt.chains:this.setData(this.regions)}switch(e.name){case rt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case rt.fitWidth:case rt.positionWidth:this.calcSize();break;case rt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case rt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;kr.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}})}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){kr.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){kr.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter(e=>this.regionTypes.includes(e.type)),n=Array.from(new Set(t.map(e=>e.order))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const r=t.find(t=>t.order==n[e]&&t.chain==o);i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe(()=>{this.calcSize()}),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe(()=>{this.calcSize()}));this.mainLayout=s.table(this.chains,e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map(t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})})],["",...[...Array(n.length).keys()].map(e=>t.find(t=>t.order==n[e]&&t.chain==this.chains[0]).name||"Name")]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(Qe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),kr.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){kr.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map(e=>this.logos[n][e].Length))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[nt.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout(()=>{e(),this.calcSizeRequested=!1},0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,async()=>{if(this.filterSource!==t){this.props.getProperty(rt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[nt.n5.filterSource]:this.filterSource})}}})}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,async()=>{this._onRendered.next()})}async awaitRendered(e=5e3){await(0,Je.PE)(this.onRendered,()=>{},()=>{this.invalidate()},e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class lt{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ct{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const r=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new ct(n,i,r)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new lt);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new lt);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function ut(e,t,n="Morgan",i=1,o=.6){const r=e.length,s=kr.seqHelper.getSeqHandler(e),a=Array(r);let l=1;const c=new Map,h=e.categories,u=e.getRawData();for(let t=0;t<r;t++){if(null===h[u[t]]||e.isNone(t)){a[t]=null;continue}a[t]="";const n=s.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[t]+=c.get(i)}}let d={};if(t===me.Z.MONOMER_CHEMICAL_DISTANCE||t===me.Z.NEEDLEMANN_WUNSCH){const e=Array.from(c.keys()),r=await(0,ye.A7)(e,n),s={};Object.entries(r.alphabetIndexes).forEach(([e,t])=>{s[c.get(e)]=t});const l=a.reduce((e,t)=>Math.max(e,t?.length||0),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},t===me.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var dt=n(4954);function pt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach(n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))}),t}function mt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach((t,i)=>{n[i]=e.activityCol.get(t)});const i={},o=kr.seqHelper.getSeqHandler(e.seqCol),r=o.defaultBiotype,a=ft(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),r,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(yt(i)),t.append(gt("Activity delta",Math.abs(n[0]-n[1]))),t.append(gt("Cliff",e.sali)),t}function gt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function ft(e,t,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=kr.monomerLib;return Ke(r,0,0,0,30,R().count(0).take(e.length).map(t=>e.getCanonical(t)).toArray(),R().count(0).take(t.length).map(e=>t.getCanonical(e)).toArray(),n,s,!0,i),o}function yt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function bt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init(n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`);n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class vt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach(e=>e.unsubscribe())}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe(e=>this.render(!0)));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe(t=>{this.gridSelect||this.render(e)})),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe(e=>this.render(!1))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe(e=>this.render(!1))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout(()=>{this.render(e),this.debounceTimer=null},100)}render(e=!0){this.renderPromise=this.renderPromise.then(async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)})}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class wt extends vt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[me.Z.NEEDLEMANN_WUNSCH,me.Z.HAMMING,me.Z.LEVENSHTEIN,me.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",me.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===me.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}}const Ct={gapPenalty:1,matchScore:1,gapSymbol:ve.b9[ve.Hi.FASTA],localAlignment:!1};class St extends wt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init(e=>this.targetColumn?.get(this.idxs?.get(e))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>this.molCol.setTag(e,this.targetColumn.getTag(e)));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe(e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout(()=>{this.createPropertyPanel(t)},300),this.gridSelect=!0)}),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Re.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Re.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex(e=>e==this.targetMoleculeIdx);this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",e=>{this.gridSelect=!1}),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await ut(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new D).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]}));n.sort((e,t)=>t.score-e.score),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init(e=>n[e].idx),this.scores=a.Column.float("score",t+1).init(e=>n[e].score)}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(e.currentRowIdx),u=function(e,t,n={}){const i={...Ct,...n};function o(e,t){return e===t?i.matchScore:-i.matchScore}const r=e.length,s=t.length,a=Array(r+1).fill(0).map(()=>Array(s+1).fill(0));let l=-9999,c=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<s+1;r++)a[n][r]=Math.max(0,a[n-1][r-1]+o(e.getCanonical(n-1),t.getCanonical(r-1)),a[n-1][r]-i.gapPenalty,a[n][r-1]-i.gapPenalty),a[n][r]>=l&&(l=a[n][r],c=[n,r]);let h=i.localAlignment?c[0]:r,u=i.localAlignment?c[1]:s,d=new Array(0),p=new Array(0);for(;h>0&&u>0;){const n=Math.max(a[h-1][u-1],a[h-1][u],a[h][u-1]);a[h][u]==a[h-1][u-1]+i.matchScore&&n==a[h-1][u-1]?(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1):a[h][u]==a[h-1][u]-i.gapPenalty?(p.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):a[h][u]==a[h][u-1]-i.gapPenalty?(d.push(i.gapSymbol),p.push(t.getCanonical(u-1)),u-=1):(d.push(e.getCanonical(h-1)),p.push(t.getCanonical(u-1)),h-=1,u-=1)}d=[...R().count(0).take(h).map(t=>e.getCanonical(t)),...d.reverse(),...i.localAlignment?R().count(c[0]).take(r).map(t=>e.getCanonical(t)):[]],p=[...R().count(0).take(u).map(e=>t.getCanonical(e)),...p.reverse(),...i.localAlignment?R().count(c[1]).take(s).map(e=>t.getCanonical(e)):[]];const m=h,g=u;return m>g?p=[...new Array(m-g).fill(i.gapSymbol.valueOf()),...p]:d=[...new Array(g-m).fill(i.gapSymbol.valueOf()),...d],p.length>d.length?d.push(...new Array(p.length-d.length).fill(i.gapSymbol.valueOf())):p.push(...new Array(d.length-p.length).fill(i.gapSymbol.valueOf())),{seq1:d.join(""),seq2:p.join(""),seq1Splitted:new ke.Mu(d,i.gapSymbol),seq2Splitted:new ke.Mu(p,i.gapSymbol)}}(c,h),d=ft(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(yt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",()=>t,!0),r.shell.o=p.root}}class At extends wt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init(e=>this.targetColumn?.get(this.renderMolIds[e]));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach(e=>t.setTag(e,this.targetColumn.getTag(e)));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe(e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]});const i=n.plot.grid();(0,Re.Kd)(i,t.name,450,30),(0,Re.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},(e,t)=>t),this.sampledIndices=null);const n=this.distanceMetric,i=await ut(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=t.map(e=>o[e]),a=new B(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=t.length,h=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),u=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(r=e-1,Math.floor(function(e){return Math.random()*e}(r)))],o=new Set;var r;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),e=>Math.min.apply(Math,i.map(function(t,n){return l[h(e,t)]})));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map(e=>t[e])}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var xt,Mt=n(5433),Et=n(3890),Tt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(xt||(xt={}));class _t{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[e,t,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class It extends _t{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n})}isFragment(){return this.isQueryOrFragment(e=>82===e||42===e)}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Lt extends It{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter(e=>e.startsWith(xt.RGP_LINE_START)).forEach(t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}});const n=t.map((e,t)=>{if(e.startsWith(xt.ATOM_ALIAS_LINE_START))return t}).filter(e=>void 0!==e),i=n.map(e=>t[e]),o=n.map(e=>t[e+1]);i.forEach((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,i)});const r=this.getRGroupAtomicIndices().filter(t=>!Array.from(e.values()).includes(t));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter(e=>e).slice(3).map(e=>parseInt(e)),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map((e,t)=>{if(e.includes("R#"))return t}).filter(e=>void 0!==e)}static isValidMolfile(e){return-1!==e.indexOf(xt.TYPE)&&-1!==e.indexOf(xt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,xt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<xt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,xt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,xt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+xt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=xt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends It{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map(e=>parseInt(e));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}}),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Pt{constructor(){}static getInstance(e){if(Pt.isMolfileV2K(e))return new Lt(e);if(Pt.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Lt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Rt=n(6197),$t=n(9124),Ot=n(3527);class kt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++kt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ht extends kt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Ft extends kt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Gt extends kt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Bt extends kt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Dt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,r,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,r=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach(e=>{i[e.label]=e.capGroupName});else{if(!r){if(t.lib)return new Bt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Dt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Vt={[Ge.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ge.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ge.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ge.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ge.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ge.o.CHEM]:{R:"#eeeeee"},[Ge.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},jt=/[\w()]+/,Wt=RegExp(String.raw`\(${jt}(,${jt})+\)`),Ut=e=>{const t=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,t,e),t},qt=new Ot.Mi([255,255,255]),zt=new Ot.Mi([0,0,0]),Yt=.7*(0,K.wQ)(qt);class Kt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every(([e,t])=>0===Object.keys(t).length);for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==ve._S||t===ve.b9[ve.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map(e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`})).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{kr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,$t.fA)(e,t),o=(0,Rt.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Ge.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Ge.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===ve._S||"*"==i?s=r.wem=new Ht(n):n===Ge.o.NUCLEOTIDE&&"N"===i||n===Ge.o.AA&&"X"===i||(Ge.o.CHEM,0)||Wt.test(i)?s=r.wem=new Ft(n,i):r.lib||(s=r.wem=new Gt(n,i,this.isEmpty)),s||(s=r.wem=Dt.fromMonomer(n,r,this))),s}getTooltip(e,t){const n=(0,Rt.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),r=this.getMonomer(n,t);if(r){const e=r.symbol,[t,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?Ut(r.molfile):r.smiles?s.divV([Ut(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=ve._S){let e=r.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(e))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Ot.Mi([...o.map(e=>e+1)]),s=(0,K.KE)(r,qt)/((0,K.wQ)(r)*(0,K.wQ)(qt)),l=i(n.backgroundcolor),c=new Ot.Mi([...l.map(e=>e+.01)]);let h;h=(0,K.KE)(c,qt)/((0,K.wQ)(c)*(0,K.wQ)(qt))<s?l:o;let u=new Ot.Mi(h);const d=(0,K.wQ)(u);return d>Yt&&(u=(0,K.dC)(zt,u,Yt/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,Rt.Y)(e),r=this.getMonomer(o,t);let s;if(r){if(r.meta&&r.meta.colors){if("string"==typeof r.meta.colors)try{r.meta.colors=JSON.parse(r.meta.colors)}catch(e){kr.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=r.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(s=e[i])}if(!s){const t=Vt[e],n=t?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=r.naturalAnalog;if(!s&&t&&t!==r.symbol)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Zt=n(5488),Xt={};Xt.styleTagTransform=S(),Xt.setAttributes=b(),Xt.insert=f().bind(null,"head"),Xt.domAPI=m(),Xt.insertStyleElement=w(),d()(Zt.A,Xt),Zt.A&&Zt.A.locals&&Zt.A.locals;class Jt extends Kt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{kr.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,Rt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach(n=>{t[n]=this._monomers[e][n].molfile}),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map(e=>this.getMonomer(t,e));return i=i.filter(e=>null!==e),0===i.length?[]:(i=i.filter(t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Pt.getInstance(t.molfile).atomTypes,i.map((e,t)=>"R#"===e?t:-1).filter(e=>-1!==e),n&&=!0,n}),i.map(e=>e?.symbol))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach(t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach(n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)})}),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Le.ub)().then(e=>{this.assignDuplicatePreferences(e)}):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find(e=>e.lib?.source===o);r?this._monomers[n][i]=r:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map(e=>`${e} ${this.getMonomerSymbolsByType(e).length}`).join("\n")}static overrideCounter=0;override(e,t){return new Qt(e,`override: ${++Jt.overrideCounter}, ${t}`,this)}}class Qt extends Kt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,o){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map(e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n})}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class tn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nn=n(7433),on=n.n(nn),rn=n(1913),sn=n.n(rn);class an{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(on())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});sn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${e}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var ln=n(8604);class cn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let o;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise(e=>o=e)]),this.eventManager.updateValidLibraryFileListRequested$.subscribe(()=>{this.updateValidLibList().then(()=>{}),r||(r=!0,o())}),this.eventManager.updateValidSetFileListRequested$.subscribe(()=>{this.updateValidSetList().then(()=>{})})}static objCounter=-1;objId=++cn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await r.dapi.files.readAsText(ln.gt),o=JSON.parse(i),s=new an(o);return new cn(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await r.dapi.files.exists(ln.so+`${t}`))return void r.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await r.dapi.files.writeAsText(ln.so+`${t}`,e),await this.updateValidLibList(),await r.dapi.files.exists(ln.so+`${t}`)?r.shell.info(`Added ${t} HELM library`):r.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),r.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await r.dapi.files.delete(ln.so+`${e}`),await this.updateValidLibList(),r.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await r.dapi.files.exists(ln.so+`${e}`)?r.shell.error(`Failed to delete ${e} library`):r.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),o=await i.readAsText(t);n=JSON.parse(o);const r={},s=[];return n.forEach(e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(r[t]={},s.push(t)),r[t][n]=e}),new Jt(r,t)}async loadSetFromFile(e,t,n){let i={};const o=new a.FileSource(t),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map(([t,n])=>{const i=t,o=n.polymerType,r=n.monomerType,s=n.set;return new en(e,i,o,r,s)});return new tn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await r.dapi.files.readAsText(ln.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter(e=>!t.includes(e));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some(e=>!e.endsWith(".json"))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${ln.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)}),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return kr.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then(async()=>{kr.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void kr.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await r.dapi.files.readAsText(ln.Es+`${e}`):t.push(e);const i=n.filter(e=>!t.includes(e));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),kr.logger.debug(`${e}, OUT`)}),kr.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some((e,n)=>e!==t[n])}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some((e,n)=>e!==t[n])}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(ln.so).then(e=>e.filter(e=>e.isFile).map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(ln.so.length))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await r.dapi.files.list(ln.Es).then(e=>e.map(e=>e.fullPath)),n=[];return n.push(...t),n.map(e=>e.substring(ln.Es.length))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise(e=>{const t=this._libFilesUpdateSubject$.pipe((0,k.skip)(1)).subscribe(n=>{e(n),t.unsubscribe()})})}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class un{logger;_monomerLib=new Jt({},"MAIN");_monomerSets=new tn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Je.cb)(e),!1))()]).then(t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)})}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++un.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return un.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await cn.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then(async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then(e=>[e.getValidLibraryPaths()]),(0,Le.ub)()]),o=t.filter(e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n});let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map(e=>this.readLibrary(ln.so,e).catch(t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Jt({},e,n)}).finally(()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then(async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then(e=>[e.getValidSetPaths()])]),n=t.filter(e=>!0);let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map(t=>this.readSet(ln.Es,t).catch(e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn("Broken monomer set",[],t,n)}).finally(()=>{e.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))]);this._monomerSets.updateSets(r)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;r.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}}),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Le.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter(t=>!e.includes(t)),await(0,Le.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter(e=>!t.includes(e))}async loadMonomerLibForTests(){await(0,Le.Eu)(ln.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new un(kr.logger);return e._eventManager=hn.getInstance(),e})()),e}}var dn=n(1757),pn=n.n(dn),mn=n(3017),gn={};gn.styleTagTransform=S(),gn.setAttributes=b(),gn.insert=f().bind(null,"head"),gn.domAPI=m(),gn.insertStyleElement=w(),d()(mn.A,gn),mn.A&&mn.A.locals&&mn.A.locals;var fn=n(3151);class yn{constructor(e,t=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add 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s=null;if(e[n].createDate)try{s=Date.parse(e[n].createDate)}catch(t){console.error(`Error parsing date ${e[n].createDate}`)}t.rows.setValues(n,[o,e[n].symbol,e[n].name,JSON.stringify(e[n].rgroups??[]),...r,e[n].monomerType,e[n].polymerType,e[n].naturalAnalog,e[n].author,s,e[n].id,JSON.stringify(e[n].meta??{}),e[n].lib?.source??""],!1);try{s&&t.col(Cn.CREATE_DATE)?.set(n,s,!1)}catch(t){console.error(`Error setting date ${e[n].createDate}`,t)}};await new Promise(e=>{const t=()=>{try{r(),e()}catch(t){console.error("Error in doFill",t),e()}};n%20==0?setTimeout(()=>{t()}):t()})}return o.close(),t.col(Cn.MONOMER).semType=a.SEMTYPE.MOLECULE,i.forEach(e=>{t.col(e).semType=a.SEMTYPE.MOLECULE}),t}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}}class Tn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout(()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Cn.NAME).width=100,this.tv.grid.col(Cn.SYMBOL).width=70)},200)}static VIEW_NAME="Manage Monomers";_newMonomer=fn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Pn(e,()=>this.activeMonomerLib,async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout(()=>{const n=t.col(Cn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))},500))},()=>this.tv?.dataFrame)}static async getInstance(){if(!this.instance){const e=await un.getInstance();await e.awaitLoaded(),await 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e=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",async()=>{const t=i(n.value);if(t)r.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){r.shell.error("Error creating library"),console.error(e)}o.close()}}).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe(({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))}),e.menu.item("Fix all monomers",()=>{this.fixAllMonomers()}),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Hn(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)}),e.menu.item("Selection To New Library",async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map(e=>Hn(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)})):e.menu.item("Remove Monomer",async()=>{const e=await Hn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)})})),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter(e=>e.name===Tn.VIEW_NAME).forEach(e=>e.close())}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(r.shell.tableViews??[]).find(e=>e.id===this.tv.id);return e?r.shell.v=e:Tn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){r.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach((e,t)=>{i[t]=e.filter(e=>0!==e.getElementsByClassName("grok-icon-filter").length)}),i=i.filter(e=>e.length>0);const o=s.icons.add(()=>{this._newMonomerForm.setEmptyMonomer()},"Add New Monomer"),l=s.iconFA("wand-magic",()=>{this.fixAllMonomers()},"Fix all monomers"),c=s.icons.edit(async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))},"Edit Monomer"),h=s.icons.delete(async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map(e=>Hn(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Hn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)});s.tooltip.bind(h,()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer");const u=s.iconFA("arrow-to-bottom",async()=>{const e=this.libInput.value;if(!e)return r.shell.error("No library selected");let t=null;try{t=await r.dapi.files.readAsText(ln.so+e)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return r.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")},"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=Tn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add(()=>{this.createNewLibDialog()},"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then(()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)}),this.tv}async editMonomer(e){return this._newMonomer=await Hn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(ln.so,e),!this.activeMonomerLib)return r.shell.error(`Library ${e} not found`),a.DataFrame.create();const t=this.activeMonomerLib.getPolymerTypes().flatMap(e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map(t=>this.activeMonomerLib.getMonomer(e,t)));return await En(t)}catch(e){throw r.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK(async()=>{const e=this.tv?.dataFrame;let t=this.libInput.value;if(e&&t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(e.rowCount).fill(0).map((t,n)=>Hn(e.rows.get(n)))),i=JSON.stringify(n.map(e=>({...e,lib:void 0,wem:void 0})),null,2);t.endsWith(".json")||(t+=".json"),await r.dapi.files.writeAsText(ln.so+t,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(t)}catch(e){r.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")}).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,e=>`[*:${e[2]}]`);return t=t.replaceAll(/\[\d\*\]/g,e=>`[*:${e[1]}]`),t.replaceAll(/\[\d\*\:\d\]/g,e=>`[*:${e[1]}]`)}const In=["alternateId","capGroupName","capGroupSMILES","label"];function Ln(e,t){const n=Object.keys(e).find(e=>e.toLowerCase()===t.toLowerCase());if(n)return e[n]}function Nn(e){return e.map(e=>{const t=function(e,t){const n={};return e.forEach(e=>{const i=Object.keys(t).find(t=>t.toLowerCase()===e.toLowerCase());i&&(n[e]=t[i])}),n}(In,e),n=Ln(t,"capGroupSMILES"),i=Ln(t,"alternateId"),o=Ln(t,"capGroupName"),r=Ln(t,"label")??"R1";if(n&&i&&o||r.length<2)return t;if(i&&-1!==i.indexOf(`${r}-`)){const e=i.replace(`${r}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${r.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(t.alternateId=`${r}-${o}`));return t}).sort((e,t)=>e.label?.localeCompare(t.label??"")??0)}class Pn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",async()=>{const e=this.validateInputs();e?r.shell.warning(e):await this.saveMonomer()}),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe(async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=$n([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map(e=>e[0])).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map(e=>Number.parseInt(e[0].match(/[1-9]/g)[0])).map(e=>this.rgroupsGrid.items.find(t=>t.label===`R${e}`)??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`});this.rgroupsGrid.items=i.sort((e,t)=>e.label?.localeCompare(t.label??"")??0),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await wn(kn(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0}));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new yn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?r.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe(()=>this.onMonomerInputChanged()),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new yn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout(()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"},200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Nn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter(([e,t])=>"colors"!==e?.toLowerCase()).map(([e,t])=>({Property:e,Value:t})),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&wn(kn(e.smiles,this.rgroupsGrid.items),e.polymerType).then(e=>{e&&(this.monomerNaturalAnalogInput.value=e)});const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find(e=>"r-groups"===e.name?.toLowerCase());if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,()=>this.saveValidationResult??"Save monomer to library"),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=$n(e.rgroups,e.smiles,e.molfile),n=r.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await r.dapi.files.readAsText(ln.so+t);i=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const o=e.map(e=>Rn(i,t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=o.map(e=>i[e]),l=s.divV(a.map(e=>this.getMonomerInfoTable(e)),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map(e=>e.symbol).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",async()=>{i=i.filter(e=>!a.includes(e)),await r.dapi.files.writeAsText(ln.so+t,JSON.stringify(i,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map(e=>e.symbol).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),u.close()}).show()}async addMonomerToLib(e,t){let n=[];try{const e=await r.dapi.files.readAsText(ln.so+t);n=JSON.parse(e)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}const i=Rn(n,t=>t.symbol===e.symbol&&t.polymerType===e.polymerType),o=this.getMonomersDataFrame()?.col(Cn.MONOMER)?.toList()?.findIndex(t=>t===e.smiles),a=async()=>{try{const i=n.findIndex(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType);i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(ln.so+t,JSON.stringify(n,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,r.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){r.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const e=await Hn(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",()=>{e.close(),a()}).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!r.chem.checkSmiles(e))return void r.shell.warning("Invalid SMILES");e=$n([],e);let t=r.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=On(t);const n={};this.metaGrid.items.filter(e=>!!e.Property&&!!e.Value).forEach(e=>{n[e.Property]=e.Value});const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Rn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function $n(e,t,n){const i=!t||!r.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)}),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,e=>`[*:${e[1]}]`),n}(o,e),o=_n(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function On(e){const t=e.split("\n"),n=t.findIndex(e=>e.startsWith("M")&&e.includes("ISO"));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex(e=>e.includes("V2000"));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map(e=>e.trim()).filter(Boolean);if(r[e-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[e-i]=s)}const s=Object.keys(r);if(-1===t.findIndex(e=>e.startsWith("M")&&e.includes("RGP"))){const e=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map(([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`).join("")}`,n=t.findIndex(e=>e.startsWith("M")&&e.includes("END"));t.splice(n,0,e)}return s.filter(e=>!!Number.parseInt(e)).map(e=>Number.parseInt(e)+i).forEach(e=>{const n=t[e].split(" "),i=n.findIndex(e=>"R#"===e);if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}}),t.join("\n")}function kn(e,t){let n=e;return t.forEach(e=>{const t=e.label[1]??"1",i=Ln(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)}),n}async function Hn(e){let t;try{t=JSON.parse(e.get(Cn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Cn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=On(i)}catch(e){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Cn.NATURAL_ANALOG);const s=e.get(Cn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Cn.R_GROUPS)??"[]"),!o&&s){const e=await wn(kn(n,l),s);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Cn.SYMBOL),name:e.get(Cn.NAME),molfile:i,smiles:n,polymerType:s,monomerType:e.get(Cn.MONOMER_TYPE),naturalAnalog:o,id:e.get(Cn.ID),rgroups:l,meta:t,author:e.get(Cn.AUTHOR),createDate:e.get(Cn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Bn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map(e=>new Gn(e));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,e),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach(e=>{e.root.onclick=()=>{this.monomerCards.forEach(e=>e.selected=!1),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)})}render(){this.monomerCards.forEach(e=>e.render())}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await un.getInstance()).getMonomerLib().onChanged.subscribe(async()=>await Dn._instance.refresh())),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Le.ub)();const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find(e=>e.lib?.source===i)??null:null;this.monomerCardRows.push(new Bn(n,this.monomers[t][n],o,async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then(async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))})}))}const t=s.divText("Set Default");if(t.addEventListener("click",async()=>{if(0===Object.keys(this.monomers??{}).length)return void r.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void r.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=s.input.choice("Default Library",{items:n,nullable:!0});s.dialog("Set Default Monomer Source for Duplicates").add(i).onOK(async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some(e=>e.lib?.source===i.value)&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Le.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),r.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout(()=>this.refresh(),100)}else r.shell.info("No library selected")}).show()}),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root));else{this.vv=s.virtualView(this.monomerCardRows.length,e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root)),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter(t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase())),this.vv.setData(this.filteredMonomerRows.length,e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root))}}}constructor(){}get root(){return this._root}}async function Vn(){await qn.showDialog()}async function jn(e=!0){return await zn.showView(e)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const e=new Wn,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Wn.instancePromise}static async reloadWidget(){const e=await Wn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe(()=>this.promptToAddLibraryFiles()),new a.Widget(e)}async getWidgetContent(){const e=await Un.createControlsForm();return pn()(e).addClass("monomer-lib-controls-form"),setTimeout(()=>{e&&pn()(e)&&pn()(e).removeClass("ui-form-condensed")},200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe(()=>{this.updateControlsForm()}),this.fileManager.eventManager.librarySelectionRequested$.subscribe(([e,t])=>{this.updateLibrarySelectionStatus(t,e)})}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){kr.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then(e=>e.getFileManager()),await(0,Le.ub)()]);return new Un(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.wideForm(e,void 0);return pn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();pn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map(e=>this.createLibInput(e))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;kr.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const o=s.iconFA("trash-alt",()=>this.promptForLibraryDeletion(e)),a=s.icons.edit(async()=>{r.shell.v=await(await Tn.getInstance()).getViewRoot(e)},"Edit monomer library");return s.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),kr.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Le.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter(e=>e!==t):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK(async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),r.shell.error(`Failed to delete ${e} library`)}}).showModal(!1)}}class qn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){qn._instance||(qn._instance=new qn,qn._instance.closeDialogSubject$.subscribe(()=>{qn._instance.dialog=void 0})),qn._instance.dialog||(qn._instance.dialog=await qn._instance.getDialog()),qn._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});pn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",()=>e.addLibraryFile(),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe(()=>{this.closeDialogSubject$.next(),i.unsubscribe()});return n}}class zn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",()=>t.addLibraryFile(),"Upload new HELM monomer library"),o=s.bigButton("Merge",()=>{this.mergeSelectedLibs()},"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach(e=>e.unsubscribe()),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(l),this._view.name=zn.viewName,e&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then(()=>{setTimeout(()=>{const e=Array.from(l.children).filter(e=>e.classList.contains("ui-box"));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`},100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe(()=>{try{const e=zn._instance;e&&e._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}}))}),this._view}static async showView(e=!0){return zn._instance||(zn._instance=new zn),zn._instance._duplicateManager||(zn._instance._duplicateManager=await Dn.getInstance()),zn._instance.libManager||(zn._instance.libManager=await un.getInstance()),e&&zn._instance._view&&Array.from(r.shell.views).find(e=>e.id&&e.id===zn._instance._view.id)?(r.shell.v=zn._instance._view,await zn._instance._duplicateManager.refresh(),zn._instance._view):(zn.closeExistingViews(),zn._instance.getView(e))}static closeExistingViews(){Array.from(r.shell.views).filter(e=>e.name===zn.viewName).forEach(e=>e.close())}async mergeSelectedLibs(){const e="Library with this name already exists",t=await un.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=h(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=o.value;return e.endsWith(".json")||(e+=".json"),e}function h(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(h),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",()=>{a.Utils.download(c(),JSON.stringify(n))}).addButton("Save",async()=>{i.close();const e=c(),t=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(t,e,!1);const n=await(0,Le.ub)();n.exclude=l,await(0,Le.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(t){r.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}}).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Yn,Kn=function(e,t,n,i){return new(n||(n=Promise))(function(o,r){function s(e){try{l(i.next(e))}catch(e){r(e)}}function a(e){try{l(i.throw(e))}catch(e){r(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n(function(e){e(t)})).then(s,a)}l((i=i.apply(e,t||[])).next())})};class Zn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe(e=>Kn(this,void 0,void 0,function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find(e=>e.text===t)})),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)});e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=r.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),()=>Kn(this,void 0,void 0,function*(){return yield this._changeStopState()}),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),()=>Kn(this,void 0,void 0,function*(){return yield this._restartScript()}),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),()=>Kn(this,void 0,void 0,function*(){this._isStepProcessed||(yield this._nextStep())}),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),()=>this._closeDock(),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Zn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",()=>this._nextStep(),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Kn(this,void 0,void 0,function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Je.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",()=>this._nextStep(),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)})}_startScript(){return Kn(this,void 0,void 0,function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()})}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Kn(this,void 0,void 0,function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),e.prepend(i);const a=setInterval(()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))},1e3)})}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Kn(this,void 0,void 0,function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))})}_restartScript(){return Kn(this,void 0,void 0,function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()})}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Zn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Kn(this,void 0,void 0,function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())})}}Zn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Yn||(Yn={}));var Xn=n(966),Jn=n(608),Qn=n(1619);class ei{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map(([e,t])=>`${e}=${encodeURIComponent(t)}`).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${kr.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case nt.n5.fixWidth:case nt.n5.fitArea:t[e]=(e=>["1","on","true"].includes(e.toLowerCase()))(n);break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ti{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ni=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ii="-";class oi extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,o,r,s){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag($e.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=r.cell.value;a&&a!==ve._S||(a=ii);const l=a.split(ve.ot).map(e=>e&&e!==ve._S?e.trim():ii),c=l.map(e=>(0,ge.zS)(e,Math.max(2,Math.floor(.15*i/l.length)))),h=c.map(t=>e.measureText(t).width),u=h.reduce((e,t)=>e+t,0);let d=t+(i-u)/2;const p=this.tableCol.getTag(ve.gp.alphabet),m=p===ge.YI.RNA||p===ge.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA;for(let a=0;a<c.length;a++){const u=l[a],p=this.getHelmType(r,m);let g=Oe.S$,f="rgb(255, 255, 255)";if(this.monomerLib)if(s){const e=this.monomerLib.getMonomerColors(p,u);g=e?.textcolor??g,f=e?.backgroundcolor??f}else g=this.monomerLib.getMonomerTextColor(p,u);s&&1==l.length&&(e.fillStyle=f,e.fillRect(t,n,i,o)),e.fillStyle=g,e.fillText(c[a],d,n+o/2,i),d+=h[a]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(ve.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),r=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==ve._S||i==ii)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA,c=i.split(ve.ot).map(t=>{if(!t||t===ve._S||t===ii)return s.divText("gap");const n=this.getHelmType(e,l);return this.monomerLib.getTooltip(n,t)}),h=s.divH(c,{style:{alignItems:"top"}}),u=Array.from(h.querySelectorAll("canvas"));if(u.length>2){const e=Math.floor(550/u.length);u.forEach(t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")})}return s.tooltip.show(h,r,a),!0}getHelmType(e,t){let n=t;if((e.tableRowIndex??-1)>-1&&e.tableColumn?.getTag(ve.qE.polymerTypeColumnName)){const t=e.tableColumn.getTag(ve.qE.polymerTypeColumnName),i=e.tableColumn.dataFrame?.col(t);if(i){const t=i.get(e.tableRowIndex);t&&["BLOB","CHEM","G","PEPTIDE","RNA"].includes(t)&&(n=(0,ke.MD)(t))}}return n}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new oi(t,n)),o}}class ri extends a.GridCellRenderer{get name(){return je.uF.MONOMER}get cellType(){return je.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,r,s){oi.getOrCreate(r).render(e,t,n,i,o,r,s)}onMouseMove(e,t){oi.getOrCreate(e).onMouseMove(e,t),t.preventDefault()}}class si{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ai extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class li extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new si(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,we.AP)(e);r.shell.error(t),this.logger.error(t,void 0,n)}}var ci=n(6307),hi=n(5999),ui={};ui.styleTagTransform=S(),ui.setAttributes=b(),ui.insert=f().bind(null,"head"),ui.domAPI=m(),ui.insertStyleElement=w(),d()(hi.A,ui),hi.A&&hi.A.locals&&hi.A.locals;class di extends a.Widget{seqCol;seqHelper;get type(){return"MacromoleculeColumnWidget"}viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=kr.properties.tooltipWebLogo,n=this.seqCol.getTag(Qe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function pi(e,t,n,i){const o=kr.seqHelper.getSeqHandler(e);let r=null,s=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(r=e),o.posList[e]==n&&(s=e);if(null===r&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(r,s,a)}const mi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class gi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??mi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${kr.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe(()=>this.nameInputInput.bind(this));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],r=JSON.parse(o.value);r&&t===r.start&&n===r.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{kr.handleErrorUI(e)})}).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter(([e,t])=>!["table","sequence"].includes(e)).map(([e,t])=>t)),t=s.button("Get Region",()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch(e=>{kr.handleErrorUI(e)})});return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var yi=n(8754);async function bi(e,t,n,i,o){const r=await async function(e,t,n,i,o){const r=(0,be.R)(t,o),s=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):ve._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===r[t]&&++l[n];l[n]/=e.length}return s}(l,r):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,ye.uL)(i,e,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,o);for(let e=0;e<r.length;e++)t.isNone(e)&&r.set(e,null,!1);return r}var vi=n(294),wi=n(330);const Ci=OCL;var Si=n(2582);class Ai{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var xi=n(6956);class Mi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach(e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)});const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter(([t,n])=>e.includes(t)).map(([e,t])=>t);this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach(e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)})}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach(e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)})}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach((t,n)=>{const i=e[n-1];i===xi.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)})}}class Ei{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter((t,n)=>!e.includes(n)),this.rawAtomLines=this.rawAtomLines.filter((t,n)=>!e.includes(n))}shift(e){this.coordinates=this.coordinates.map(t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}})}rotate(e){this.coordinates=this.coordinates.map(t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),r=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:r}})}}class Ti extends Ei{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map(e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))}))}get atomLines(){return this.rawAtomLines.map((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`})}}class _i{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter((t,n)=>!e.includes(n)),this.bondedAtomPairs=this.bondedAtomPairs.filter((t,n)=>!e.includes(n))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach((n,i)=>{n.forEach((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})})}),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach(e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t})}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t>e?t-1:t))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map(t=>t.map(t=>t+e))}}class Ii extends _i{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map(e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))])}getBondLines(){return this.bondedAtomPairs.map((e,t)=>{if(e.some(e=>-1===e))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`})}}class Li extends Ai{constructor(e,t){super(t);const n=Pt.getInstance(e);this.atoms=new Ti(n),this.bonds=new Ii(n),this.rGroups=new Mi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni extends Ei{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map((e,n)=>({x:e,y:t[n]}))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(e,(e,t,n,i,o,a)=>t+r+i+s+a).replace(t,"")})}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class Pi extends _i{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map(e=>[e[0],e[1]])}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map((t,n)=>{if(t.some(e=>-1===e))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,(e,n,i,o,r,s)=>`${n}${t[0]}${o}${t[1]}${s}`)})}}class Ri extends Ai{constructor(e,t){super(t);const n=Pt.getInstance(e);this.atoms=new Ni(n),this.bonds=new Pi(n),this.rGroups=new Mi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class $i{static getInstance(e,t){if(Pt.isMolfileV2K(e))return new Li(e,t);if(Pt.isMolfileV3K(e))return new Ri(e,t);throw new Error("Unsupported molfile version")}}class Oi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,r){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;Pt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=$i.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Oi.molfileV2KToV3KCache.has(e))return Oi.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Oi.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map(e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,""))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class ki{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Si.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===ve.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Oi(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach(n=>{e.push(t),t+=n.getAtomLines().length}),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach(e=>{const t=e.map(e=>e.monomerIdx),n=e.map(e=>e.rGroupId),i=t.map(e=>this.monomerWrappers[e]),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])})}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach((e,t)=>{e.shiftBonds(n[t])}),this.restoreBondsBetweenMonomers();const i=new vi.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const r=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Ge.o.NUCLEOTIDE:Ge.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(r).take(n.atomCount).toArray(),bonds:R().count(s).take(n.bondCount).toArray()})}const o=e.length,r=t.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map((e,n)=>{const i=n+1;return e.replace(t,(e,t,n,o)=>t+i+o)}),"M  V30 END BOND"].join("\n")}}class Hi{constructor(e){this.molfileHandler=Pt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Fi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map(e=>null===e?"":e))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map(e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return Ci.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,we.AP)(e);return kr.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map(e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,r=this.convertToMolfileV3KColumn(e).toList().map(e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null}),s=`molfile(${e.name})`,l=o?o.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map(e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map(e=>e.molfile),i=(0,wi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=vi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,we.AP)(e);kr.logger.error(t,void 0,n),o=vi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],r=new Hi(o),s=new ki(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach((e,t)=>{const n=r.getMonomerShifts(t);s.addMonomer(e,t,n)});const a=s.compileToMolfile(),l=new vi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new vi.vF(a.molfile,l)}}class Gi{seqHelper;_column;_units;_notation;_defaultGapOriginal;_notationProvider=null;_tempReadForNotProvider=!1;get notationProvider(){return this._tempReadForNotProvider||(this._tempReadForNotProvider=!0,this._notationProvider=this._notationProvider??this._column.temp[Pe.j.notationProvider]??null),this._notationProvider}set notationProvider(e){this._notationProvider=e}_splitter=null;_refinerPromise=Promise.resolve();get refinerPromise(){return this._refinerPromise}constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),(this.isCustom()||this.isBiln())&&(this.notationProvider=this.column.temp[Pe.j.notationProvider]??null);const i=this.isFasta()?ve.b9[ge.Hi.FASTA]:this.isSeparator()?ve.b9[ge.Hi.SEPARATOR]:this.isHelm()?ve.b9[ge.Hi.HELM]:this.isCustom()||this.isBiln()?this.notationProvider?.defaultGapOriginal??ve.b9[ge.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom()&&!this.isBiln())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider?.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||(this.isCustom()||this.isBiln())&&this.notationProvider||e.temp.seqHandlerRefined||(this._refinerPromise=this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,r=null;for(const t of e){const e=t?n(t):[];if(null===r?r=e.length:e.length!==r&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map(e=>this.column.get(e)):this.column.categories.slice(0,100)).map(e=>e?e.substring(0,500):"").filter(e=>0!==e.length))],0,e=>e.split(this.separator));let t=!1;const n=a.Func.find({tags:["notationRefiner"]});for(const i of n)try{const n=i.prepare({col:this.column,stats:e,separator:this.separator}),o=(await n.call()).getOutputParamValue();t||=o}catch(e){console.error(e)}t&&(this._tempReadForNotProvider=!1,delete this.column.temp[Pe.j.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,ke.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some(e=>e.length>1);e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,ke.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?Ge.o.NUCLEOTIDE:Ge.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===ve.b9[ge.Hi.FASTA]?ve._S:i??ve._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(ve._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(e<n.length){const o=n[e];i[s]=t?o===ve.b9[ge.Hi.FASTA]?ve._S:o??ve._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new Pe.C(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM||this.notation===ge.Hi.BILN?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ge.YI.DNA||e===ge.YI.RNA||e===ge.YI.PT}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map(e=>this.getSplitted(e).length).reduce((e,t)=>e>t?e:t,0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map(e=>e.trim()):R().count(1).take(this.maxLength).map(e=>e.toString()).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isBiln(){return this.notation===ge.Hi.BILN}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;if(this.units.toLowerCase().startsWith(ge.Hi.BILN))return ge.Hi.BILN;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,r=e.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=o.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let h=o.getTag(ge.gp.alphabet);h||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(h=ge.YI.UN),null!=h&&l.setTag(ge.gp.alphabet,h);let u=o.getTag(ge.gp.alphabetSize);null!=h&&u&&l.setTag(ge.gp.alphabetSize,u);const d=o.getTag(ge.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,u)),e===ge.Hi.BILN&&(l.setTag(ge.gp.separator,"-"),l.meta.units=ge.Hi.SEPARATOR),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some(t=>e.startsWith(t.toLowerCase()))}static getNewColumnFromParams(e,t,n){if(!Gi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:ke.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return me.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return me.Z.LEVENSHTEIN}getDistanceFunction(){return me.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?ve.b9[ge.Hi.FASTA]:ve.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),r=(0,ge.qp)(e),s=[];for(let e=0;e<r.length;++e){let n=r.getOriginal(e);if(o&&(n=n.replace(fn.EK,"$1")),n===ve.b9[ge.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init(e=>{const t=this.getSplitted(e);return n(t)}),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,r=t??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=ve.b9[this.notation];i.init(e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new ke.Mu(n,l))});const c=e=>{const t=e.split(",").map(e=>e.trim()),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},h=this.column.getTag(ge.gp.positionNames);h&&i.setTag(ge.gp.positionNames,c(h));const u=this.column.getTag(ge.gp.positionLabels);return u&&i.setTag(ge.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ge.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Bi(e,n,o.isHelm())};break;case ge.Hi.HELM:{const e=o.alphabet===ge.YI.DNA||o.alphabet===ge.YI.RNA,t=o.getHelmWrappers();i=function(n){return Di(n,t,e)};break}case ge.Hi.BILN:i=function(e){return Vi(e)};break;default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};if(e===ge.Hi.BILN)return function(e){return n.convertToBiln(e)};throw new Error("Unexpected target units '"+e+"'.")}static forColumn(e,t){let n=e.temp[Pe.j.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Pe.j.seqHandler]=new Gi(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let r=e.getOriginal(i);t&&(r=r.replace(fn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.FASTA]:o===fn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Bi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=this.isDna()||this.isRna();return Di(this.splitter(e),t,n)}convertToBiln(e){return this.notation==ge.Hi.BILN?e:Vi(this.splitter(e))}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let r=t.getOriginal(e);(i||o)&&(r=r.replace(fn.EK,"$1"),r=r===fn.q7?null:r),n[e]=r||null}return new ke.Mu(n.filter(e=>!!e),ve.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider?.createCellRendererBack(e,t)),i}}function Bi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let r=e.getOriginal(t);n&&(r=r.replace(fn.EK,"$1")),o===ve._S?r=ve.b9[ge.Hi.SEPARATOR]:o===fn.q7&&(r=""),i[t]=r}return i.join(t)}function Di(e,t,n){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const i=n?"RNA":"PEPTIDE",o="$$$",r=e.graphInfo.disjointSeqStarts,s=t[1],a=t[2],l=[];for(let t=0;t<r.length;t++){const o=r[t],c=t+1<r.length?r[t+1]:e.length,h=new Array(c-o);for(let t=o;t<c;++t){const i=e.getCanonical(t);let r=i;i===ve._S?r=ve.b9[ge.Hi.HELM]:(n&&(r=r.replace(fn.EK,"$1")),r=1===r.length?`${s}${r}${a}`:`${s}[${r}]${a}`),h[t-o]=r}l.push(`${i}${t+1}{${h.join(".")}}`)}return`${l.join("|")}$${e.graphInfo.connections.map(e=>`${i}${e.seqIndex1+1},${i}${e.seqIndex2+1},${e.monomerIndex1+1}:R${e.rGroup1}-${e.monomerIndex2+1}:R${e.rGroup2}`).join("|")}${o}V2.0`}{const[i,o,r,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=i;i===ve._S?s=ve.b9[ge.Hi.HELM]:(n&&(s=s.replace(fn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[t]=s}return`${i}${a.join(".")}${s}`}}function Vi(e){if(e.graphInfo&&(e.graphInfo.connections?.length??0)>0){const t=e.graphInfo.disjointSeqStarts,n=new Array(e.length);for(let t=0;t<e.length;++t)n[t]=e.getCanonical(t),n[t]?.includes("-")&&(n[t]=`[${n[t]}]`);for(let i=0;i<e.graphInfo.connections.length;i++){const o=e.graphInfo.connections[i],r=`${i+1}`,s=o.seqIndex1,a=o.seqIndex2,l=t[s]+o.monomerIndex1,c=t[a]+o.monomerIndex2,h=`${n[l]}(${r},${o.rGroup1})`,u=`${n[c]}(${r},${o.rGroup2})`;n[l]=h,n[c]=u}return t.map((i,o)=>{const r=o+1<t.length?t[o+1]:e.length;return n.slice(i,r).join("-")}).join(".")}{const t=new Array(e.length);for(let n=0;n<e.length;++n)t[n]=e.getCanonical(n),t[n]?.includes("-")&&(t[n]=`[${t[n]}]`);return t.join("-")}}class ji{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Gi.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,$t.b2)();return new Fi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return vi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return vi.vF.createEmpty();let r=null;try{let e=o.molfile;if(i){if(r=this.rdKitModule.get_mol(e),!r)return vi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),e=r.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new vi.vF(e,o.monomers)}catch(e){const[t,n]=(0,we.AP)(e);return kr.logger.error(t,void 0,n),vi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),s=e.dataFrame,l=(0,wi.qj)(s,e.name),c=await this.getHelmToMolfileConverter(o),h=e.toList(),u=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n])}if(t&&p){const t=await p.apply({mols:u});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(u[n]=t[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,Gi.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),Gi.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,Gi.setTags(e)}}async function Wi(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM,ge.Hi.BILN].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await Fr.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,60)?.length??100)>50)return t="Maximum number of monomers is 50",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);Object.entries(e.cell.column.tags).forEach(([e,t])=>{i.setTag(e,t)}),e.cell.column.temp[Pe.j.notationProvider]&&(i.temp[Pe.j.notationProvider]=e.cell.column.temp[Pe.j.notationProvider]);const r=n.getSplitted(e.cell.rowIndex),s=(r.graphInfo?.connections?.length??0)>0,l=n.isHelm()&&new Set(r.graphInfo?.polymerTypes??[]).size>1;if(await Fr.toAtomicLevel(o,i,s||l,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const c=o.columns.byIndex(1).get(0);return c?{errorText:"",mol:c}:(t="No structure generated",{errorText:t,mol:""})}catch(e){kr.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Ui="#333333",qi="rgba(60, 177, 115, 0.1)",zi="rgba(240, 240, 240, 0.5)",Yi="rgba(100, 100, 100, 0.3)";class Ki{constructor(e=Ji.DEFAULT_TRACK_HEIGHT,t=Ji.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class Zi extends Ki{constructor(e=new Map,t=Ji.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,Ji.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator((e,t,n)=>this.createTooltipContent(e,t,n))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Ge.o.NUCLEOTIDE;break;default:t=Ge.o.AA}const n=Array.from(e.values()).reduce((e,t)=>e+t,0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,ci.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(s.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(s.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(s.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,r=Array.from(i.entries()).sort((e,t)=>t[1]-e[1]),s=r.reduce((e,[t,n])=>e+n,0),a=this.height;let l=0;for(const[e,t]of r){const n=t*a/s;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=t+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,e,t,n,i,o,r,s,a,h,c)}drawWebLogoColumn(e,t,n,i,o,r,s,a,l,c,h){const u=r+e-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=t+e*s,m=s-2;r+e===l&&(this.ctx.fillStyle=qi,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=zi,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(e,t,n,i,o,r){const s=Array.from(r.entries()).sort((e,t)=>t[1]-e[1]),a=s.reduce((e,[t,n])=>e+n,0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,u),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=s,this.ctx.fillRect(t,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class Xi extends Ki{constructor(e,t=Ji.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,Ji.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=e+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,t,i),l===a&&(this.ctx.fillStyle=qi,this.ctx.fillRect(c,t,h,i)))}}drawConservationBar(e,t,n,i,o,r){if(!this.ctx)return;const s=this.data[e];this.ctx.fillStyle=zi,this.ctx.fillRect(t+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*s);a=`rgb(255, ${e}, ${e})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+r-l,n-4,l),this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Ui,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Ji={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Qi={BASE:Ji.DOTTED_CELL_HEIGHT+Ji.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Ji.TITLE_HEIGHT+Ji.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Ji.DEFAULT_TRACK_HEIGHT+Ji.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Ji.DEFAULT_TRACK_HEIGHT+Ji.TRACK_GAP}};class eo{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||Qi.BASE,sliderHeight:e.sliderHeight||Ji.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach(e=>{e.setVisible(!1),e.setHeight(Ji.DEFAULT_TRACK_HEIGHT)}),!(e<Qi.WITH_TITLE()||e<Qi.WITH_WEBLOGO()))if(e<Qi.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-Qi.WITH_WEBLOGO();t.setHeight(Ji.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>Qi.WITH_BOTH()){const n=e-Qi.WITH_BOTH();t.setHeight(Ji.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)}),e<Qi.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<Qi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Qi.WITH_TITLE()?(Ji.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(e,t,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+r/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=Qi.WITH_WEBLOGO();else{if("conservation"!==e)return;t=Qi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach((e,t)=>{this.userSelectedTracks[t]=!1})),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame(()=>this.redraw())}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?Qi.WITH_BOTH():Qi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame(()=>this.redraw())}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=Qi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,Ji.TITLE_HEIGHT),this.ctx.fillStyle=Ui,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+Ji.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach(e=>{e instanceof Zi&&e.setHovered(-1,null)}),window.requestAnimationFrame(()=>this.redraw()))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0,l=this.config.headerHeight-Ji.SLIDER_HEIGHT-Ji.DOTTED_CELL_HEIGHT,c=l-Ji.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){h=e,u=n-i;break}g=i-Ji.TRACK_GAP}let f=null;if(h){const e=this.tracks.get(h);e&&(f=e.getMonomerAt(t,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=f,h)){const e=this.tracks.get(h);e instanceof Zi&&(e.setHovered(r,f),window.requestAnimationFrame(()=>this.redraw()))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=f,h)){const t=this.tracks.get(h);if(t){const n=t.getTooltipContent(r,f);if(n)return void s.tooltip.show(n,e.clientX+16,e.clientY+16)}}h&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame(()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(e,t,n,i,o,r,s,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Qi.WITH_TITLE();l&&Ji.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Ji.SLIDER_HEIGHT,h=c-Ji.DOTTED_CELL_HEIGHT,u=h-Ji.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const g=this.getTrack("conservation");g&&g.isVisible()&&p.push({id:"conservation",track:g});let f=u;for(const{track:e}of p){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-Ji.TRACK_GAP}if(this.drawDottedCells(0,h,n,Ji.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:Ji.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=t+Ji.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=e+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,t),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Ui,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,Ji.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,Ji.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,Ji.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-Ji.SLIDER_HEIGHT;return t>n&&t<n+Ji.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-Ji.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Ji.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")}),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Qi.WITH_TITLE()?Ji.TITLE_HEIGHT:0,a=this.config.headerHeight-Ji.SLIDER_HEIGHT-Ji.DOTTED_CELL_HEIGHT,l=a-Ji.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of u){const i=m-t.getHeight();if(n>=i&&n<m){c=e,h=n-i;break}m=i-Ji.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init(e=>i[e]===t)}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach(t=>t.init(e))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Qi.WITH_TITLE()&&t&&(to(e.left??0,n,i)||to(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-t/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-Ji.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Qi.BASE,WITH_TITLE:Qi.WITH_TITLE(),WITH_WEBLOGO:Qi.WITH_WEBLOGO(),WITH_BOTH:Qi.WITH_BOTH()}}}function to(e,t,n){return e>=t&&e<=n}class no{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){no.conservationCache=new a.LruCache(100),no.webLogoCache=new a.LruCache(100),no.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return no.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return no.conservationCache.getOrCreate(i,()=>{const o=no.getWebLogoChunk(e,t,n,i),r=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(s+=t,t>a&&(a=t));r[i-t]=s>0?a/s:0}return r})}static getWebLogoChunk(e,t,n,i){return no.webLogoCache.getOrCreate(i,()=>{const i=e.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=e.getSplitted(i).getOriginalRegion(t,n);if(0!==r.length)for(let e=0;e<r.length;e++){const n=r[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o})}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),r=Math.floor(t/no.CHUNK_SIZE)*no.CHUNK_SIZE,s=Math.ceil(n/no.CHUNK_SIZE)*no.CHUNK_SIZE;for(let t=r;t<s;t+=no.CHUNK_SIZE){const n=Math.min(t+no.CHUNK_SIZE,i),r=no.getChunkCacheKey(e.column,t,n),s=no.getConservationChunk(e,t,n,r);for(let e=0;e<s.length&&t+e<i;e++)o[t+e]=s[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,r=Math.floor(t/no.CHUNK_SIZE)*no.CHUNK_SIZE,s=Math.ceil(n/no.CHUNK_SIZE)*no.CHUNK_SIZE;for(let t=r;t<s;t+=no.CHUNK_SIZE){const n=Math.min(t+no.CHUNK_SIZE,i),r=no.getChunkCacheKey(e.column,t,n),s=no.getWebLogoChunk(e,t,n,r);for(const[e,t]of s.entries())e<i&&o.set(e,t)}return o}}class io extends Zi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=no.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=no.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class oo extends Xi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=no.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),r=Math.min(this.maxLength,t+20),s=no.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(e,t,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,r,s,a)}}class ro{separator;seqHelper;seqCol;splitter;get defaultGapOriginal(){return""}constructor(e,t,n){this.separator=e,this.seqHelper=t,this.seqCol=n,this.splitter=ke.bR.bind(this)}setUnits(){}getHelm(e,t){const n=this.splitter(e);return this.seqHelper.getSeqHandler(this.seqCol).getJoiner({notation:ve.Hi.HELM})(n)}createCellRendererBack(e,t){const n=kr.properties.maxMonomerLength||4,i=new so(e,t,n,this.seqHelper);return i.init().then(()=>{}),i}}class so extends Oe.Jy{constructor(e,t,n,i){super(e,t,kr.logger,n,()=>{const e=i.getSeqHandler(t),{font:n,fontWidth:o}=Oe.Jy.getFontSettings(t);return{seqHandler:e,font:n,fontCharWidth:o,separatorWidth:0,monomerToShort:ke.zS}})}}async function ao(){return await Fr.getMonomerLibHelper()}async function lo(){await Fr.initBio()}function co(e){return Fr.sequenceTooltip(e)}async function ho(e){return await Fr.standardiseMonomerLibrary(e)}async function uo(e,t,n){await Fr.matchWithMonomerLibrary(e,t,n)}function po(){return Fr.getBioLib()}function mo(e){return Fr.getSeqHandler(e)}function go(e){return Fr.getRegionPanel(e)}async function fo(e){return await Fr.libraryPanel(e)}function yo(e){Fr.GetRegionEditor(e)}function bo(e){Fr.SplitToMonomersEditor(e)}function vo(e){Fr.SequenceSpaceEditor(e)}function wo(e){Fr.SeqActivityCliffsEditor(e)}function Co(){return Fr.customSequenceCellRenderer()}function So(){return Fr.fastaSequenceCellRenderer()}function Ao(){return Fr.separatorSequenceCellRenderer()}function xo(){return Fr.bilnSequenceCellRenderer()}function Mo(e,t,n){return Fr.refineNotationProviderForBiln(e,t,n)}function Eo(e){return Fr.macroMolColumnPropertyPanel(e)}function To(e){return Fr.compositionAnalysisWidget(e)}function _o(){return Fr.macromoleculeDifferenceCellRenderer()}function Io(e,t,n,i,o){return Fr.sequenceAlignment(e,t,n,i,o)}function Lo(){return Fr.webLogoViewer()}function No(){return Fr.vdRegionsViewer()}function Po(e,t,n,i){return Fr.getRegion(e,t,n,i)}async function Ro(e,t,n,i,o){await Fr.getRegionTopMenu(e,t,n,i,o)}async function $o(e,t,n,i,o,r,s,a,l){return await Fr.activityCliffs(e,t,n,i,o,r,s,a,l)}async function Oo(e,t,n,i,o){return await Fr.macromoleculePreprocessingFunction(e,t,n,i,o)}async function ko(e,t){return await Fr.helmPreprocessingFunction(e,t)}async function Ho(e,t,n,i,o,r,s,a,l){return await Fr.sequenceSpaceTopMenu(e,t,n,i,o,r,s,a,l)}async function Fo(e,t,n,i){await Fr.toAtomicLevel(e,t,n,i)}async function Go(e){await Fr.toAtomicLevelAction(e)}async function Bo(e){return await Fr.toAtomicLevelPanel(e)}async function Do(e){return await Fr.sequence3dStructureWidget(e)}function Vo(){Fr.multipleSequenceAlignmentDialog()}async function jo(e,t,n){return await Fr.alignSequences(e,t,n)}async function Wo(){return await Fr.compositionAnalysis()}function Uo(e){return Fr.importFasta(e)}function qo(e){return Fr.importBam(e)}function zo(){Fr.convertDialog()}function Yo(e){Fr.convertColumnAction(e)}function Ko(){return Fr.monomerCellRenderer()}async function Zo(e){return await Fr.testDetectMacromolecule(e)}async function Xo(e,t){return await Fr.splitToMonomersTopMenu(e,t)}function Jo(e){return Fr.getHelmMonomers(e)}function Qo(){return Fr.similaritySearchViewer()}function er(){return Fr.similaritySearchTopMenu()}function tr(){return Fr.diversitySearchViewer()}function nr(){return Fr.diversitySearchTopMenu()}function ir(e){Fr.searchSubsequenceEditor(e)}function or(e){Fr.SubsequenceSearchTopMenu(e)}async function rr(e,t,n){return await Fr.sequenceIdentityScoring(e,t,n)}async function sr(e,t,n){return await Fr.sequenceSimilarityScoring(e,t,n)}async function ar(){await Fr.manageMonomerLibraries()}async function lr(){await Fr.manageLibrariesView()}async function cr(){await Fr.manageMonomersView()}async function hr(){return await Fr.manageMonomerLibrariesView()}async function ur(e){await Fr.manageMonomerLibrariesViewTreeBrowser(e)}function dr(){Fr.saveAsFasta()}function pr(){return Fr.bioSubstructureFilter()}function mr(){return Fr.bioSubstructureFilterTest()}async function gr(){await Fr.webLogoLargeApp()}async function fr(){await Fr.webLogoAggApp()}async function yr(){await Fr.getRegionApp()}async function br(){await Fr.getRegionHelmApp()}function vr(){Fr.longSeqTableSeparator()}function wr(){Fr.longSeqTableFasta()}function Cr(){Fr.longSeqTableHelm()}function Sr(e,t){Fr.addCopyMenu(e,t)}async function Ar(){await Fr.demoBioSimilarityDiversity()}async function xr(){await Fr.demoBioSequenceSpace()}async function Mr(){await Fr.demoBioActivityCliffs()}async function Er(){await Fr.demoBioAtomicLevel()}async function Tr(e){await Fr.sdfToJsonLib(e)}async function _r(e,t){return await Fr.seq2atomic(e,t)}async function Ir(e,t){return await Fr.seqIdentity(e,t)}async function Lr(e,t,n){await Fr.detectMacromoleculeProbe(e,t,n)}async function Nr(){return await Fr.getSeqHelper()}async function Pr(e,t,n){return await Fr.getMolFromHelm(e,t,n)}var Rr=function(e,t,n,i){var o,r=arguments.length,s=r<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)s=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(s=(r<3?o(s):r>3?o(t,n,s):o(t,n))||s);return r>3&&s&&Object.defineProperty(t,n,s),s},$r=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},Or=function(e,t){return function(n,i){t(n,i,e)}};const kr=new li;let Hr=null;r.decorators||(r.decorators={}),["func","init","param","panel","editor","demo","app","appTreeBrowser","fileHandler","fileExporter","model","viewer","filter","cellRenderer","autostart","dashboard","folderViewer","semTypeDetector","packageSettingsEditor","functionAnalysis","converter","fileViewer","model","treeBrowser","polyfill"].forEach(e=>{r.decorators[e]||(r.decorators[e]=function(e){return function(e,t,n){}})});class Fr{static async getMonomerLibHelper(){return await un.getInstance()}static async initBio(){null===Hr&&(Hr=async function(){const e="Bio: _package.initBio()";kr.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Ne.j)(),i=await kr.getProperties(),o=new ai(i);kr.properties=o;const s=await un.getInstance(),l=await(0,Le.ub)();l.explicit&&(l.explicit=[],await(0,Le.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();kr.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new ji(s,n);kr.completeInit(p,c,u,n),kr.logger.debug(`${e}, end`),function(){const e=e=>{setTimeout(()=>{if(e.isDetached)return;const t=e.dataFrame;if(!t)return;const n=t.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=kr.seqHelper.getSeqHandler(i)}catch(e){continue}if(!n)continue;if(n.isHelm()||n.alphabet===ge.YI.UN)continue;const o=e.col(i.name);if(!o)continue;let s=!!e.tableView&&Array.from(e.tableView.viewers).some(e=>"Sequence Position Statistics"===e.type);if(n.isMsa()){const l=(e,t)=>Number.isNaN(e)?t:e,c=()=>l(Math.max(Number.parseInt(i.getTag(ge.gp.positionShift)??"0"),0),0)+1,u=()=>l(Number.parseInt(i.getTag(ge.gp.selectedPosition)??"-2"),-2),d=()=>Oe.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const g=i.categories;for(let e=0;e<g.length;e++){const t=g[e];t&&t.length>m&&(m=t.length,p=e)}const f=g[p],y=n.splitter(f),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let w;w=i.length>1e5||b<50?v.WITH_TITLE:i.length>5e4?v.WITH_WEBLOGO:v.WITH_BOTH;let C=null,S=null;const A=a.debounce(h.merge(t.onFilterChanged,t.onDataChanged.pipe((0,k.filter)(e=>e?.args?.column===i))),100).subscribe(()=>{no.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),S&&(S.resetViewportTracking(),S.forceUpdate()),setTimeout(()=>{e.isDetached||e.invalidate()},50)});e.sub(A);const x=r=>{const l=[],h=new oo(n,b,45,"default","Conservation");S=h,l.push({id:"conservation",track:h,priority:1});const p=new io(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new eo({canvas:e.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(t,n)=>{setTimeout(()=>{const o=c(),r=u();if(o!==n.start&&i.setTag(ge.gp.positionShift,(n.start-1).toString()),r!==t&&(i.setTag(ge.gp.selectedPosition,t.toString()),t>=0&&!s&&e.tableView&&R()(e.dataFrame?.columns.numerical).find(e=>!0))){s=!0;const t=e.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});e.tableView.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}})},onHeaderHeightChange:t=>{e.isDetached||t<v.WITH_TITLE||setTimeout(()=>e.props.colHeaderHeight=t)}},o);m.setupTooltipHandling(),l.forEach(({id:e,track:t})=>{m.addTrack(e,t)}),m.setSelectionData(t,i,n),b>50&&(e.props.colHeaderHeight=w,setTimeout(()=>{e.isDetached||(o.width=400)},300)),e.sub(e.onCellRender.subscribe(e=>{const t=e.cell;if(!t||!t.isColHeader||t?.gridColumn?.name!==o?.name)return;const n=e.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,u(),s,e,i.name)}))};(0,ye.pj)().then(e=>{const t=e.getMonomerLib();x(t)}).catch(e=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)})}}},1e3)},t=(r.events.onViewerAdded.subscribe(t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)}),r.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await Hr}static sequenceTooltip(e){const t=new di(e,kr.seqHelper);return t.init().then(()=>{}).catch(e=>{const t=e instanceof Error?e.message:e.toString();r.shell.error(t)}),t}static async standardiseMonomerLibrary(e){return await async function(e){const t=JSON.parse(e);if(!t||!Array.isArray(t)||0===t.length)throw new Error("Invalid library format, expected an array of monomers");const n=(await Mn(t)).map(e=>({...e,lib:void 0,wem:void 0}));return JSON.stringify(n,null,2)}(e)}static async matchWithMonomerLibrary(e,t,n="PEPTIDE"){const i=await async function(e,t,n,i="PEPTIDE"){const o=a.Func.find({package:"Chem",name:"convertMoleculeNotation"})[0];if(!o)throw new Error("Function convertMoleculeNotation not found, please install Chem package");const r=n.getMonomerSymbolsByType(i).map(e=>n.getMonomer(i,e)).filter(e=>e&&(e.smiles||e.molfile)),s=(await Mn(r)).map((e,t)=>({sym:e.symbol,smiles:kn(e.smiles??"",e.rgroups??[]),original:e.smiles,source:r[t]?.lib?.source})).filter(e=>!!e?.smiles&&!e.smiles.includes("[*:")),l=a.Column.fromList(a.COLUMN_TYPE.STRING,"MonomerSmiles",s.map(e=>e.smiles));l.semType=a.SEMTYPE.MOLECULE;const c=await o.apply({molecule:l,targetNotation:a.chem.Notation.Smiles});if(!c||c.length!==l.length)throw new Error("Error canonicalizing monomer smiles");c.toList().forEach((e,t)=>s[t].smiles=e);const h=e.col(t),u=await o.apply({molecule:h,targetNotation:a.chem.Notation.Smiles});if(!u||u.length!==h.length)throw new Error("Error canonicalizing molecules");const d=u.toList(),p=e.clone(),m=p.columns.addNewString(p.columns.getUnusedName("Matched monomer smiles"));m.semType=a.SEMTYPE.MOLECULE;const g=p.columns.addNewString(p.columns.getUnusedName("Matched monomer symbol"));g.semType="Monomer";const f=p.columns.addNewString(p.columns.getUnusedName("Matched monomer source"));p.columns.setOrder([t,g.name,m.name,f.name]);for(let e=0;e<d.length;e++){const t=d[e];if(t)for(let n=0;n<s.length;n++)if(s[n].smiles===t){m.set(e,s[n].original,!1),g.set(e,s[n].sym,!1),f.set(e,s[n].source??"",!1);break}}return p}(e,t.name,kr.monomerLib,n);r.shell.addTableView(i)}static getBioLib(){return kr.monomerLib}static getSeqHandler(e){return kr.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:kr.name,name:t});if(1!==n.length)throw new Error(`Package '${kr.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new fi(i,kr.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=s.label("Manage monomer libraries");return pn()(e).addClass("d4-link-action"),e.onclick=async()=>await Vn(),new a.Widget(e)}()}static GetRegionEditor(e){try{new fi(e,kr.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(`Get region editor error: ${t}`),kr.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ti;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK(async()=>e.func.prepare(t.funcParams).call(!0)).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static SeqActivityCliffsEditor(e){const t=new Se({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK(async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()});n.history(()=>({editorSettings:t.getStringInput()}),e=>t.applyStringInput(e.editorSettings)),n.show()}static customSequenceCellRenderer(){return new qe}static fastaSequenceCellRenderer(){return new qe}static separatorSequenceCellRenderer(){return new qe}static bilnSequenceCellRenderer(){return new qe}static refineNotationProviderForBiln(e,t,n){return"-"===n&&(!(!Object.keys(t.freq).some(e=>e.match(/^.+\(\d{1,2},\d{1,2}\)$/))&&!Object.keys(t.freq).some(e=>e.includes("[")||e.includes("]")))&&(e.setTag("aligned","SEQ"),e.setTag("alphabet","UN"),e.setTag(".alphabetIsMultichar","true"),e.meta.units=ge.Hi.BILN,e.temp[Pe.j.notationProvider]=new ro(n,kr.seqHelper,e),!0))}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter(e=>e.semType===a.SEMTYPE.MOLECULE).map(e=>e.name);new Set(t).delete(e.name);let n=kr.properties?kr.properties.maxMonomerLength:4;if($e.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag($e.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout(()=>{i.value=null},0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=kr.properties?kr.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;e.meta.units!==ge.Hi.HELM&&(d=s.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,h,c,u];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ge.gp.alphabet],r=o===ge.YI.DNA||o===ge.YI.RNA?Ge.o.NUCLEOTIDE:Ge.o.AA,l={},c=n.getSeqHandler(e.cell.column),h=e.cell.rowIndex,u=c.getSplitted(h),d={};R().count(0).take(u.length).filter(e=>!u.isGap(e)).forEach(e=>{let t=u.getCanonical(e);r===Ge.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;if(l[t]=n+1,!d[t]&&u.graphInfo?.polymerTypes){const n=u.graphInfo.polymerTypes[e];d[t]=(0,ke.MD)(n)}});const p=(0,ci.F)(l,r,t,Object.keys(d).length?d:void 0);return Array.from(p.rows).forEach(e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t}),i.appendChild(p),new a.Widget(i)}(e,kr.monomerLib,kr.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new Ye}static sequenceAlignment(e,t,n,i,o){const r=new ht(i,o,n,t);return"Local alignment"==e?r.smithWaterman():r.needlemanWunsch()}static webLogoViewer(){return new nt.oP}static vdRegionsViewer(){return new at}static getRegion(e,t,n,i){return pi(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const s=pi(t,n??null,i??null,o??null);t.dataFrame.columns.add(s),await r.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,h,u,d,p){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);if(!(0,Xn.V)(t,"Activity Cliffs"))return;const m=Ee(e),g={units:t.meta.units,aligned:t.getTag(ge.gp.aligned),separator:t.getTag(ge.gp.separator),alphabet:t.getTag(ge.gp.alphabet)},f=h,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,f,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,g,u,pt,mt,bt,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),S=await new Promise((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK(async()=>{b().then(e=>t(e)).catch(e=>n(e))}).onCancel(()=>{t(void 0)}).show():b().then(e=>t(e)).catch(e=>n(e))}).catch(e=>{const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}).finally(()=>{C.close()});return S?.props?.xColumnName&&S?.props?.yColumnName&&e.col(S.props.xColumnName)&&e.col(S.props.yColumnName)&&(e.col(S.props.xColumnName).set(0,e.col(S.props.xColumnName).get(0)),e.col(S.props.yColumnName).set(0,e.col(S.props.yColumnName).get(0))),S}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:r,options:s}=await ut(e,t,o,n,i);return{entries:r,options:s}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,dt.BQ)(e,kr.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await r.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=W.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,s,c,h,u){if(e.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${e.name} is not a current table view`);const d=r.shell.tv.dataFrame==e?r.shell.tv:void 0;return(0,Xn.V)(t,"Sequence Space")?(s||(s=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await _e(e,[t],n,[i],[1],[s],"MANHATTAN",o,h??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Hr;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??kr.monomerLib,r=kr.seqHelper,s=kr.rdKitModule;await(0,yi.V)(e,t,n,i,o,r,s)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Wi(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(s.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(t.mol,e,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){kr.logger.error(e)}return a.Widget.fromRoot(s.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Wi(e);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=Ci.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then(function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()}),n=s.div([t],{style:{aspectRatio:"1"}})}catch(e){n=s.divText("Couldn't get 3D structure")}}catch(e){n=s.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,Qn.D)({},kr.seqHelper).catch(e=>{const[t,n]=(0,we.AP)(e);if(e instanceof Jn.Ap)return r.shell.warning(e.element),void kr.logger.warning(t);r.shell.error(t),kr.logger.error(t,void 0,n)})}static async alignSequences(e=null,t=null,n){return(0,Qn.D)({col:e,clustersCol:t,...n},kr.seqHelper)}static async compositionAnalysis(){const e=r.shell.tv,t=e.dataFrame.columns.toList().filter(e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(kr.seqHelper.getSeqHandler(e),!0)),n=async t=>{if(!(0,Xn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map(e=>e.name),i=t.find(e=>kr.seqHelper.getSeqHandler(e).isMsa()),o=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK(async()=>{const e=t.find(e=>e.name==o.value)??null;e&&await n(e)}).show()}else i=t[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}static importFasta(e){return new fe.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Re.me)()[0];(0,Mt.C)(e,kr.seqHelper)}static convertColumnAction(e){(0,Mt.C)(e,kr.seqHelper)}static monomerCellRenderer(){return new ri}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(e,!0,"")).filter(e=>e.fileName.endsWith(".csv"));let i=0;const o=[];for(const s of n)try{const t=await r.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${e}`,s}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Je.cb)(10),!(0,Xn.V)(t,"Sequence space"))return e;const n=kr.seqHelper,i=(0,be.R)(t,n);i.name="splitToMonomers";const o=t.dataFrame;for(const e of i.columns)e.semType=je.uF.MONOMER,e.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=e=>{s.lastIndex=0;const t=e.match(s);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=je.uF.MONOMER,n.setTag(ve.gp.alphabet,t.getTag(ve.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return o}(e,t)}static getHelmMonomers(e){return kr.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new St(kr.seqHelper)}static similaritySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new At(kr.seqHelper)}static diversitySearchTopMenu(){const e=r.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Re.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new dt.a7(t,kr.seqHelper)}static SubsequenceSearchTopMenu(e){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),r.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=kr.seqHelper;return bi(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=kr.seqHelper;return bi(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Vn()}static async manageLibrariesView(){await jn()}static async manageMonomersView(){const e=await Tn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await jn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e){(await(await un.getInstance()).getFileManager()).getValidLibraryPaths().forEach(t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe(async()=>{const e=await Tn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()})})}static saveAsFasta(){(0,Et.TE)()}static bioSubstructureFilter(){return new Tt._i(kr.seqHelper,kr.logger)}static bioSubstructureFilterTest(){return new Tt._i(kr.seqHelper,kr.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new ei(e,"webLogoLargeApp"),n=await kr.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new ei(e,"webLogoAggApp"),n=await kr.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new gi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await kr.files.readCsv("samples/HELM_empty_vals.csv"),n=new gi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,Ie.dW)());r.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(kr.seqHelper,ge.Hi.FASTA)]);r.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,Ie.Hx)(kr.seqHelper,ge.Hi.HELM)]);r.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ge.Hi).filter(e=>e!==ge.Hi.CUSTOM);t.group("Copy").items(i,t=>{const i=e.column,o=e.rowIndex,s=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?kr.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${t}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")})}(e,t,kr.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await kr.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=r.shell.addTableView(e);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Re.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await r.functions.eval("Bio:SeqSpaceDemo"),t=await r.dapi.projects.find(e.id);await t.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await kr.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=r.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Fr.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,me.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),pn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find(e=>e!==t.grid&&e.type===a.VIEWER.GRID);o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;r.shell.error(t),kr.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await kr.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e);const t=r.shell.addTableView(e),n=e.col("HELM");await Fr.toAtomicLevel(e,n,!0,!1),(0,Re.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Re.Kd)(t.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}static async sdfToJsonLib(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await Fr.getMonomerLibHelper()).getMonomerLib(),l=kr.seqHelper,c=await(0,Ne.j)(),h=(await(0,yi.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(e){const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await bi(i,n,t,pe.IDENTITY,kr.seqHelper)).get(0)}catch(e){const[t,n]=(0,we.AP)(e);throw kr.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(e),u=t?h.getCol(t):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Je.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await Fr.initBio(),kr.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=kr.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,kr.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,t,n,kr.monomerLib)}}Rr([r.decorators.func({description:"Returns an instance of the monomer library 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e=Date.now()-n.start;n.start=r.now()-e}this.set(t,n.value,n)}}set(e,t,n={}){if(void 0===t)return this.delete(e),this;const{ttl:i=this.ttl,start:o,noDisposeOnSet:r=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#H(e,t,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#R(e,"set"),this;let h=0===this.#a?void 0:this.#c.get(e);if(void 0===h)h=0===this.#a?this.#g:0!==this.#f.length?this.#f.pop():this.#a===this.#t?this.#G(!1):this.#a,this.#h[h]=e,this.#u[h]=t,this.#c.set(e,h),this.#d[this.#g]=h,this.#p[h]=this.#g,this.#g=h,this.#a++,this.#F(h,c,a),a&&(a.set="add"),l=!1;else{this.#E(h);const n=this.#u[h];if(t!==n){if(this.#S&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:t}=n;void 0===t||r||(this.#C&&this.#i?.(t,e,"set"),this.#A&&this.#y?.push([t,e,"set"]))}else r||(this.#C&&this.#i?.(n,e,"set"),this.#A&&this.#y?.push([n,e,"set"]));if(this.#k(h),this.#F(h,c,a),this.#u[h]=t,a){a.set="replace";const e=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==e&&(a.oldValue=e)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(h,i,o),a&&this.#O(a,h)),!r&&this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}return this}pop(){try{for(;this.#a;){const e=this.#u[this.#m];if(this.#G(!0),this.#x(e)){if(e.__staleWhileFetching)return e.__staleWhileFetching}else if(void 0!==e)return e}}finally{if(this.#A&&this.#y){const e=this.#y;let t;for(;t=e?.shift();)this.#o?.(...t)}}}#G(e){const t=this.#m,n=this.#h[t],i=this.#u[t];return this.#S&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#A)&&(this.#C&&this.#i?.(i,n,"evict"),this.#A&&this.#y?.push([i,n,"evict"])),this.#k(t),e&&(this.#h[t]=void 0,this.#u[t]=void 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s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,o.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:o,alphabetIndexes:s}={...r,...e};Object.entries(s).forEach(([e,n])=>t[e.charCodeAt(0)]=n);const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,r)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,h=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let u=1;u<r.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<e.length+1;d++){const 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i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),g=n(5553),f=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,r){if(super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe(()=>{this._onRendered.next()})),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe(()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(t=>t.args.source===this.tableCol&&e.includes(t.args.key))),200).subscribe(e=>{this.reset()})),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter(e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift)),200).subscribe(e=>{this.reset()}))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,r){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const h=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,g=Math.max(0,Math.floor(m/s)),f=[];let y=0;for(let e=0;e<g&&y<h.length;e++){const t=[];for(let e=0;e<p&&y<h.length;e++){const n=h[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}f.push({lineIdx:e,elements:t})}return{lineLayouts:f,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,h.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe(()=>{this.reset()})),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return 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t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(t/i)+o,s=n.splitter(e),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=s.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,r=n.getSplitted(e),s=Math.min(o,r.length);let a=this._monomerLengthList[e];if(null===a||a.length!=s-t){a=this._monomerLengthList[e]=new Array(r.length);let i=0;for(let e=t;e<s;++e){const 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