@datagrok/bio 2.22.5 → 2.22.7

package/dist/package-test.js

@@ -1,8 +1,8 @@
-var bio_test;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>o});var r=n(7362);class o extends r.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,o)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,o)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new o({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in o.aaSynonyms?o.aaSynonyms[e]:e;return super.get(t)}}o.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class s{static getPalette(e="grok"){switch(e){case"grok":return o.GrokGroups;case"lesk":return o.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",r="";for(const o of e)"("==o?t++:")"==o?t--:t?n+=o:r+=o;return isNaN(parseInt(n))?[r,n]:[r,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[r,o]=this.getInnerOuter(e);if(r=r.length>6?`${r.slice(0,3)}...`:r,o=o.length>6?`${o.slice(0,3)}...`:o,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,o,1]:[this.undefinedColor,r,o,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,o,2]:[this.undefinedColor,r,o,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,o,3]:[this.undefinedColor,r,o,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,o,4]:[this.undefinedColor,r,o,4]}return[this.undefinedColor,r,o,0]}}s.SemType="Aminoacids",s.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",s.undefinedColor="rgb(100,100,100)",s.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},s.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},s.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},s.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>o});var r=n(6082);async function o(){const e=r.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},3599:(e,t,n)=>{"use strict";n.d(t,{o:()=>r.o});var r=n(6869)},9124:(e,t,n)=>{"use strict";n.d(t,{b2:()=>s,fA:()=>i});var r=n(7389),o=n(6082);async function s(){const e="Helm",t=o.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}function i(e,t){if(!e)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,r;const o=e;return"ATOM"===o.T?(n=o.biotype(),r=o.elem):(n=e,r=t),[n,r]}o.JsInputBase,Error,r.input.helmAsync=async function(e,t){return(await s()).createHelmInput(e,t)}},8438:(e,t,n)=>{"use strict";function r(e){return e.startsWith("[")&&e.endsWith("]")?e.slice(1,-1):e}n.d(t,{D:()=>r})},8123:(e,t,n)=>{"use strict";n.d(t,{u:()=>r});const r={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(e,t,n)=>{"use strict";n.d(t,{Eu:()=>a,ub:()=>i});var r=n(4328);const o="Libraries";let s=Promise.resolve();async function i(){let e;return s=s.then((async()=>{const t=r.userSettings.getValue(o,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await s,e}async function a(e){s=s.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),r.userSettings.add(o,"Settings",JSON.stringify(e),!0)})),await s}},5553:(e,t,n)=>{"use strict";n.d(t,{Qc:()=>E,WN:()=>C});var r=n(1991),o=n.n(r);const s="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,i=new Set,a="object"==typeof process&&process?process:{},c=(e,t,n,r)=>{"function"==typeof a.emitWarning?a.emitWarning(e,t,n,r):console.error(`[${n}] ${t}: ${e}`)};let l=globalThis.AbortController,u=globalThis.AbortSignal;if(void 0===l){u=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(e,t){this._onabort.push(t)}},l=class{constructor(){t()}signal=new u;abort(e){if(!this.signal.aborted){this.signal.reason=e,this.signal.aborted=!0;for(const t of this.signal._onabort)t(e);this.signal.onabort?.(e)}}};let e="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const t=()=>{e&&(e=!1,c("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). 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r=n(6082),o=n(1991),s=n.n(o),i=n(330),a=n(3599);async function c(e,t,o,c,l,u,d){const h=e.length,p=e.dataFrame,m=Math.max(navigator.hardwareConcurrency-2,1),f=new Array(m).fill(null).map((()=>new Worker(new URL(n.p+n.u(455),n.b)))),g=h/m,y=new Array(m),b=u.getSeqHandler(e),w="RNA"==c?a.o.NUCLEOTIDE:a.o.AA,v=s().count(0).take(e.length).map((e=>{const t=b.getSplitted(e);return s().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:w}))).toArray()})).toArray();for(let e=0;e<m;e++){const n=f[e],r=Math.floor(e*g),s=e===m-1?h:Math.floor((e+1)*g);y[e]=new Promise((e=>{n.onmessage=t=>{e(t.data)}})),n.postMessage({seqList:v,monomersDict:t,alphabet:o,polymerType:c,start:r,end:s})}const A=[],E=[];await Promise.all(y).then((e=>{for(const t of e)A.push(...t.molfiles),E.push(...t.warnings)})),setTimeout((()=>{f.forEach((e=>{e.terminate()}))}),0);const C=(0,i.qj)(p,e.name),T=r.Column.fromType(r.COLUMN_TYPE.STRING,C,e.length).init((e=>A[e]?.molfile));return 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e={};s.f6.forEach((t=>{e[t]=c[t]})),o.set(c.symbol,e)}}return o}function l(e,t,n,s){if(0===e.length)return o.vF.createEmpty();const c=m,{atomCount:l,bondCount:d,needsCapping:p}=c(e,t,n,s),g=new Array(l),y=new Array(d);let b,w=null,v=null;"PEPTIDE"===s?b=u:(b=h,w=n===i.YI.DNA?(0,o.xb)(t,r.u.DEOXYRIBOSE):(0,o.xb)(t,r.u.RIBOSE),v=(0,o.xb)(t,r.u.PHOSPHATE));const A={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},E={sugar:w,phosphate:v,seqLength:e.length,atomCount:l,bondCount:d},C=new o.Cg,T=[];let S,_=0;for(A.i=0;A.i<E.seqLength;++A.i){const n=e[A.i];if(n.symbol===i._S)continue;const r=(0,o.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)});S=r.terminalR2Atom;const s=A.nodeShift,c=A.bondShift;b(r,g,y,A,E),r.stereoAtoms?.forEach((e=>T.push(e+_))),_+=r.atoms.x.length;const l=A.nodeShift-s,u=new Array(l);for(let e=0;e<l;++e)u[e]=s+e;const d=A.bondShift-c,h=new 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BEGIN COLLECTION\n${t.join("")}M  V30 END COLLECTION\n`}(T)),M+=r.u.V3K_END_CTAB_BLOCK,M+=r.u.V3K_END,{molfile:M,monomers:C}}function u(e,t,n,r){r.flipFactor=(-1)**(r.i%2),d(e,t,n,r)}function d(e,t,n,o){!function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const s=n.nodeShift+o+1;t[n.nodeShift+o]=r.u.V3K_BEGIN_DATA_LINE+s+" "+e.atoms.atomTypes[o]+" "+f(n.backbonePositionShift[0]+e.atoms.x[o])+" "+f(n.backbonePositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}}(e,t,o),p(e,n,o),function(e,t,n){if(0!==n.backboneAttachNode){const o=n.bondShift,s=n.backboneAttachNode,i=e.meta.terminalNodes[0]+n.nodeShift;t[n.bondShift-1]=r.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+i+"\n"}}(e,n,o),null!==e.meta.branchShift&&e.meta.terminalNodes.length>2&&function(e,t){t.branchAttachNode=t.nodeShift+e.meta.terminalNodes[2];for(let n=0;n<2;++n)t.branchPositionShift[n]=t.backbonePositionShift[n]+e.meta.branchShift[n]}(e,o),function(e,t){t.backboneAttachNode=t.nodeShift+e.meta.terminalNodes[1],t.bondShift+=e.bonds.atomPairs.length+1,t.nodeShift+=e.atoms.atomTypes.length,t.backbonePositionShift[0]+=e.meta.backboneShift?.[0]??0,t.backbonePositionShift[1]+=t.flipFactor*(e.meta.backboneShift?.[1]??0)}(e,o)}function h(e,t,n,o,s){if(0===o.i)d(s.sugar,t,n,o);else for(const e of[s.phosphate,s.sugar])d(e,t,n,o);!function(e,t,n,o){(function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const s=n.nodeShift+o+1;t[n.nodeShift+o]=r.u.V3K_BEGIN_DATA_LINE+s+" "+e.atoms.atomTypes[o]+" "+f(n.branchPositionShift[0]+e.atoms.x[o])+" "+f(n.branchPositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}})(e,t,o),p(e,n,o),function(e,t,n){const o=n.bondShift,s=n.branchAttachNode,i=e.meta.terminalNodes[0]+n.nodeShift;t[o-1]=r.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+i+"\n"}(e,n,o);const 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r=n(4328),o=n(6082),s=n(1991),i=n.n(s),a=n(439),c=n(3561),l=n(9235),u=n(294),d=n(9192),h=n(330),p=n(8123);async function m(e,t,n,s,c){if(t.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let u=t;const p=s.getSeqHandler(t);let m,g;p.notation!==a.Hi.SEPARATOR&&(u=p.convert(a.Hi.SEPARATOR,"."),u.name=t.name);try{g=s.getSeqHandler(u).alphabet,m=(0,h.pz)(g)}catch(e){const[t,n]=(0,d.AP)(e);return{molCol:null,warnings:[t]}}const y=function(e,t){const n=e.length,o=new Array(n),s=t.getSeqHandler(e);let a=!1;const c=s.defaultBiotype;for(let e=0;e<n;++e){const t=s.getSplitted(e);a||(a=0===t.length),o[e]=i().count(0).take(t.length).filter((e=>!t.isGap(e))).map((e=>({position:e,biotype:c,symbol:t.getCanonical(e)}))).toArray()}return a&&r.shell.warning(`Some values in the "${e.name}" column are empty`),o}(u,s),b=f(y,m,g,n,c),w=u.length,v=await(0,l.R)(u,b,g,m,n,s,c);return v.warnings.length>.05*w&&r.shell.warning(`Molfile conversion resulted in ${v.warnings.length} errors`),v}function f(e,t,n,r,o){const s=(0,c.Hb)(r,t,n),i={},l={value:null};if("RNA"===t){const e=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of e)g(i,n.symbol,s,o,t,l)}for(let n=0;n<e.length;++n){const r=e[n];for(const e of r){const n=e.symbol;if(""!==n)try{if("RNA"===t&&3===n.split(/\(|\)/).filter((e=>!!e)).length){const e=n.split(/\(|\)/)[1];g(i,e,s,o,t,l),i[t]?.[e]&&(i[t][n]=i[t][e])}else g(i,n,s,o,t,l)}catch(e){const t=e instanceof Error?e.message:e.toString(),r=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${t}\n${r}`),new Error(`Can't get monomer '${n}' from library: ${t}`)}}}return i}function g(e,t,n,r,o,s){const i={polymerType:o,symbol:t};if(!(0,u.bq)(e,i)){const a=function(e,t,n,r,o){if(t.has(e)){const 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o=e.meta.terminalNodes[0]-1;const s=e.meta.rNodes[1]-1;_(e,-n[o],-r[o]);const i=E(n[e.meta.rNodes[2]-1],r[e.meta.rNodes[2]-1]);C(e.atoms,-i),n[e.meta.rNodes[0]-1]>n[e.meta.rNodes[1]-1]&&T(e);const a=E(n[s],r[s]);C(e.atoms,3*Math.PI/2-a),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,r=e.meta.rNodes[2]-1,o=e.meta.terminalNodes[2]-1,s=t[r]-t[o],i=n[r]-n[o];return Math.atan2(s,i)}(e),o=e.meta.terminalNodes[0]-1,_(e,-n[o],-r[o])}(w,o):e===p.u.PHOSPHATE.symbol?function(e){const t=e.meta.rNodes[1]-1,n=e.meta.rNodes[0]-1,r=e.atoms.x,o=e.atoms.y;_(e,-r[t],-o[t]);const s=E(r[n],o[n]);C(e.atoms,Math.PI/2-s)}(w):function(e,t){const n=e.atoms.x,r=e.atoms.y,o=e.meta.terminalNodes[0]-1,s=e.meta.rNodes[0]-1;_(e,-n[o],-r[o]);const i=E(n[s],r[s]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");C(e.atoms,Math.PI-i+a);const l=function(e,t){return(0,c.YN)(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:r[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:r[e.meta.terminalNodes[0]-1]});if(1!=l)for(let e=0;e<n.length;++e)n[e]=(0,c.YN)(n[e]/l),r[e]=(0,c.YN)(r[e]/l)}(w,o),function(e,t,n){if("PEPTIDE"===e){b(t,e);const n=v(t,t.meta.rNodes[1]);n?.removedAtom&&(t.terminalR2Atom=n.removedAtom)}else n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(v(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],y(t.bonds,t.meta),b(t,e),v(t,t.meta.rNodes[1]),v(t,t.meta.rNodes[0]),v(t,t.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],_(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),b(t,e),v(t,t.meta.rNodes[1]))}(r,w,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===p.u.HYDROGEN&&(v(e,t+1),--t),++t}(w),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)"oh"===e.atoms.atomTypes[t]?.toLowerCase()&&(e.atoms.atomTypes[t]="O"),"?"===e.atoms.atomTypes[t]&&(e.atoms.atomTypes[t]="H"),++t}(w),function(e){const t=" RGROUPS=(1 1)";for(let n=0;n<(e.atoms.kwargs?.length??0);n++){const r=e.atoms.kwargs[n];r&&r.includes(t)&&(e.atoms.kwargs[n]=r.replace(t,""))}}(w),w}var s;return null}(t,n,r,o,s);if(!a)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);(0,u.LQ)(e,i,a)}}function y(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const r=t.terminalNodes,o=e.atomPairs;let s=0,i=0;for(;s<o.length&&i<r.length;){for(let e=0;e<r.length;++e)for(let t=0;t<2;++t)o[s][t]===n[e]&&(r[e]=o[s][(t+1)%2],n.length,++i);++s}}function b(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=w(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=w(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function w(e,t,n){return[(0,c.YN)(e.atoms.x[t]-e.atoms.x[n]),(0,c.YN)(e.atoms.y[t]-e.atoms.y[n])]}function v(e,t){if(void 0!==t){const n=t-1,r=e.atoms,o=e.bonds,s=e.meta,i=r.atomTypes.splice(n,1)[0];r.x=A(Float32Array,r.x,n,1),r.y=A(Float32Array,r.y,n,1),r.kwargs.splice(n,1);for(let e=0;e<s.terminalNodes.length;++e)s.terminalNodes[e]>t?--s.terminalNodes[e]:s.terminalNodes[e]===t&&(s.terminalNodes[e]=-1);for(let e=0;e<s.rNodes.length;++e)s.rNodes[e]>t?--s.rNodes[e]:s.rNodes[e]===t&&(s.rNodes[e]=-1);let a=0;for(;a<o.atomPairs.length;){const e=o.atomPairs[a][0],n=o.atomPairs[a][1];e===t||n===t?(o.atomPairs.splice(a,1),o.bondTypes=A(Uint32Array,o.bondTypes,a,1),o.bondConfiguration.has(a)&&o.bondConfiguration.delete(a),o.kwargs.has(a)&&o.kwargs.delete(a),--a):(o.atomPairs[a][0]=e>t?e-1:e,o.atomPairs[a][1]=n>t?n-1:n),++a}let c=Array.from(o.bondConfiguration.keys());return c.forEach((e=>{if(o.bondConfiguration.has(e)&&e>n){const t=o.bondConfiguration.get(e);o.bondConfiguration.delete(e),o.bondConfiguration.set(e-1,t)}})),c=Array.from(o.kwargs.keys()),c.forEach((e=>{if(o.kwargs.has(e)&&e>n){const t=o.kwargs.get(e);o.kwargs.delete(e),o.kwargs.set(e-1,t)}})),i?{removedAtom:i}:void 0}}function A(e,t,n,r){const o=new e(t.length-r);let s=0,i=0;for(;s<t.length;)s===n&&(s+=r),o[i]=t[s],++i,++s;return o}function E(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const r=t/e,o=Math.atan(r);n=e<0?Math.PI/2+o:-Math.PI/2+o}return n}function C(e,t){if(0!==t){const n=e.x,r=e.y,o=Math.cos(t),s=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=(0,c.YN)(t*o-r[e]*s),r[e]=(0,c.YN)(t*s+r[e]*o)}}}function T(e){S(e,!1)}function S(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const r=1===t?3:1;n.set(e,r)}}function _(e,t,n){const r=e.atoms.x,o=e.atoms.y;for(let e=0;e<r.length;++e)r[e]=(0,c.YN)(r[e]+t),void 0!==n&&(o[e]=(0,c.YN)(o[e]+n))}},294:(e,t,n)=>{"use strict";function r(e,t){return e[t.polymerType]?.[t.symbol]}function o(e,t){return!!e[t.polymerType]?.[t.symbol]}function s(e,t,n){let r=e[t.polymerType];r||(r=e[t.polymerType]={}),r[t.symbol]=n}n.d(t,{Cg:()=>i,LQ:()=>s,bq:()=>o,vF:()=>a,xb:()=>r});class i extends Map{constructor(e){super(e)}}class a{constructor(e,t){this.molfile=e,this.monomers=t}static createEmpty(){return new a("",new i(null))}}},330:(e,t,n)=>{"use strict";n.d(t,{pz:()=>s,qj:()=>o,vG:()=>i});var r=n(2003);function o(e,t){return function(e,t){return e?e.columns.getUnusedName(t):t}(e,`molfile(${t})`)}function s(e){let t;if(e===r.YI.PT||e===r.YI.UN)t="PEPTIDE";else{if(e!==r.YI.RNA&&e!==r.YI.DNA)throw new Error(`Unexpected alphabet '${e}'.`);t="RNA"}return t}function i(e){const t=7===e.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e);return t?[parseInt(t[1],16)/256,parseInt(t[2],16)/256,parseInt(t[3],16)/256,t.length>4?parseInt(t[4],16)/256:.3]:null}},1093:(e,t,n)=>{"use strict";n.d(t,{A:()=>o,Q:()=>s});var r=n(7362);class o extends r.e{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new o({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class s{}s.SemType="Nucleotides",s.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",s.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>r});class r{static makePalette(e,t=!1,n=r){const o={};return e.forEach((e=>{const n=e[0],r=e[1];n.forEach(((e,n)=>{o[e]=this.colourPalette[r][t?0:n]}))})),new n(o)}constructor(e){this._palette=e}get(e,t){return this._palette[e]}}r.undefinedColor="rgb(100,100,100)",r.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 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96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(e,t,n)=>{"use strict";n.d(t,{O:()=>s,n:()=>o});var r=n(1858);class o{constructor(e,t=!0,n){return this.substructure=e,this.readOnly=t,this.logger=n,new Proxy(this,{set:(e,t,n)=>{if(this.logger?.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class s{constructor(){this.onChanged=new r.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&"logger"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(e,t,n)=>{"use strict";n.d(t,{$u:()=>c,oT:()=>d});var r=n(6082),o=n(7362),s=n(6718);function i(e,t=!0){if(null==e)return"rgb(100,100,100)";const n=r.Color.fromHtml(e);if(t){const e=r.Color.g(n),t=r.Color.r(n),o=r.Color.b(n),s=Math.sqrt(Math.pow(0-t,2)+Math.pow(0-e,2)+Math.pow(0-o,2));if(s>210)return`rgb(${t/s*210},${e/s*210},${o/s*210})`}return r.Color.toRgb(n)}class a{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class c{}class l extends c{get(e,t){return"#666666"}}class u extends c{static get palette(){return u._pallete||(u._pallete=u.buildPalette()),u._pallete}static buildPalette(){return(0,s.pj)().then((e=>{e.awaitLoaded(1/0).then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{u.customMonomerColors={},u.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const r of n){const n=t.getMonomer(e,r);n?.meta?.colors?.default?.background&&(this.customMonomerColors[r]||(this.customMonomerColors[r]={}),this.customMonomerColors[r][e]=i(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(o.e.colourPalette))}get(e,t){const n=u.palette.length,r=u.customMonomerColors[e],o=t??"PEPTIDE";if(r&&r[o])return r[o];const s=a.hashCode(e)%n;return i(u.palette[s])}}u._pallete=null,u.customMonomerColors={},u.polymerTypes=[];class d extends o.e{static get Gray(){return void 0===this.gray&&(this.gray=new l),this.gray}static get Color(){return void 0===this.color&&(this.color=new u),this.color}}},6642:(e,t,n)=>{"use strict";n.d(t,{BG:()=>i,sD:()=>c});var r=n(4328),o=n(1858),s=n(8070);function i(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const r=e.cell.column;if(t=t??(r?r.temp:null),!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,r,t]}class a{onKeyDown(e,t){}onKeyPress(e,t){}onMouseEnter(e,t){}onMouseLeave(e,t){}onMouseDown(e,t){}onMouseUp(e,t){}onMouseMove(e,t){}onClick(e,t){}onDoubleClick(e,t){}}class c extends a{constructor(e,t,n){super(),this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++c.viewerCounter,this.errors=[],this._onRendered=new o.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((e=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(e){this.logger.error(e)}})))),this.tableCol&&this.subs.push(r.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(r.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,s.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}c.viewerCounter=-1},673:(e,t,n)=>{"use strict";n.d(t,{s:()=>r});const r={true:"1",false:"0"}},6882:(e,t,n)=>{"use strict";n.d(t,{Bb:()=>b,Jy:()=>w,S$:()=>y,U0:()=>v});var r=n(7389),o=n(6082),s=n(1991),i=n.n(s),a=n(8312),c=n(2003),l=n(6642),u=n(6718),d=n(9192),h=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";function b(e,t,n){if((n??0)>0&&t<(e[0]??0)+n)return-1;t-=n??0;let r,o=100,s=0,i=e.length-1;for(;s<=i;){if(r=Math.floor((i+s)/2),e[r]<=t&&t<e[r+1])return r;if(t<e[r]?i=r-1:s=r+1,--o<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}class w extends l.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,r,s){if(super(e,t,n),this.monomerLengthLimit=r,this.propsProvider=s,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const e=[c.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&e.includes(t.args.key)))),200).subscribe((e=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((e=>e.args.source===this.tableCol&&e.args.key===c.gp.positionShift))),200).subscribe((e=>{this.reset()})))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,r,o,s){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,d.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:i,monomerSpacing:a}=this.calculateFontBasedSpacing(e),c=t-2*this.padding;let l=0;const u=[];if(r.length>0)for(let t=o;t<r.length;t++){const n=r.getOriginal(t),o=this.props.monomerToShort(n,s);u.push({text:o,posIdx:t}),l=Math.max(l,e.measureText(o).width)}if(0===u.length)return{lineLayouts:[],lineHeight:i};const h=l;let p=Math.floor((c+a)/(h+a));p=Math.max(1,p);const m=n-2*this.padding,f=Math.max(0,Math.floor(m/i)),g=[];let y=0;for(let e=0;e<f&&y<u.length;e++){const t=[];for(let e=0;e<p&&y<u.length;e++){const n=u[y],r=this.padding+e*(h+a);t.push({posIdx:n.posIdx,x:r,width:h,om:n.text,isSeparator:!1}),y++}g.push({lineIdx:e,elements:t})}return{lineLayouts:g,lineHeight:i}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,u.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,d.AP)(e);this.logger.error(t,void 0,n)}const r=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[r,this.getSummedMonomerLengths(r)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=this.padding;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,s=Math.ceil(t/r)+o,i=n.splitter(e),a=Math.min(s,i.length),c=new Array(a-o);let l=0;for(let e=o;e<a;++e){const r=i.getOriginal(e),s=this.props.monomerToShort(r,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(c[e-o]=a,l+=a,l>t)break}return c}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/r)+t,s=n.getSplitted(e),i=Math.min(o,s.length);let a=this._monomerLengthList[e];if(null===a||a.length!=i-t){a=this._monomerLengthList[e]=new Array(s.length);let r=0;for(let e=t;e<i;++e){const o=s.getOriginal(e),i=this.props.monomerToShort(o,this.monomerLengthLimit),c=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+i.length*this.props.fontCharWidth;if(a[e-t]=c,r+=c,r>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:r}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,s=this.positionShift,i=Math.ceil(this.colWidth/o)+s;for(let e=n;e<r;e++){if(this._processedRows.get(e)&&i<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,i),r=Math.min(i,n.length);r-s>t.length&&t.push(...new Array(r-s-t.length).fill(o));let a=0;for(let e=s;e<r;++e){const r=n.getOriginal(e),o=this.props.monomerToShort(r,this.monomerLengthLimit),i=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(t[e-s]=Math.max(t[e-s]??0,i),a+=i,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,i),this._processedRows.set(e,!0)}return t}getPosition(e,t,n,r){const[o,s]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:b(s,t,r)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}get positionShift(){const e=Number.parseInt(this.tableCol?.tags[c.gp.positionShift]??"0")??0;return isNaN(e)?0:Math.max(e,0)}render(e,t,n,r,s,a,l){const u=a.grid?.canvas===e.canvas;if(!this.seqHelper)return;const m=this.tableCol,f=this.positionShift;e.save();try{const l=this.seqHelper.getSeqHandler(m);let d=this.monomerLengthLimit;if(h.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(h.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=d){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(d),this.setSeparatorWidth(l.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const g=a.cell.rowIndex,b=a.cell.value;u&&(r=v(a.grid,e,t,r,window.devicePixelRatio)),e.beginPath(),e.rect(t,n,r,s),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const w=m.meta.units,A=m.getTag(c.gp.aligned),E=m.getTag(c.gp.separator)??"",C=u?l.getSplitted(g):l.splitter(b);let T=h.yg.classic;A?.includes("MSA")&&w===c.Hi.SEPARATOR&&(T=h.yg.MSA);const S=m.temp["reference-sequence"],_=this.tableCol.temp["current-word"],P=(()=>{const e=(0,l.splitter)(null!=S&&""!==S?S:_??"");return i().count(0).take(e.length).slice(f).map((t=>e.getCanonical(t))).toArray()})(),M=Number.parseInt(m.getTag(c.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const i=[],c=this.calculateMultiLineLayoutDynamic(e,r,s,C,f,d);let u=n+this.padding;1===c.lineLayouts.length&&(u=n+(s-c.lineHeight)/2);for(const r of c.lineLayouts){const s=u+r.lineIdx*c.lineHeight;for(const u of r.elements){const d=t+u.x,p=u,g=p.posIdx,b=C.getCanonical(g);let w=y;const v=this.getMonomerLib();v&&(w=v.getMonomerTextColor(l.defaultBiotype,b));let A=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&P.length>0){const e=g-f;e>=0&&e<P.length&&b===P[e]&&(A=.7)}i.push({lineIdx:r.lineIdx,monomerIdx:g-f,bounds:new o.Rect(u.x,s-n,u.width,c.lineHeight),sequencePosition:g}),(0,h.oZ)(e,p.om,d,s,u.width,c.lineHeight,{color:w,isMultiLineContext:!0,transparencyRate:A,selectedPosition:isNaN(M)||M<1?void 0:M,wordIdx:g})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,i)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(f)?e.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,r);u||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,r)));const i=this.props.separatorWidth+1*this.props.fontCharWidth,c=Math.min(C.length,Math.ceil(r/i)+f);for(let i=f;i<c;++i){const c=i<C.length?C.getOriginal(i):l.defaultGapOriginal,u=i<C.length?C.getCanonical(i):l.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(l.defaultBiotype,u));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:E,last:i===C.length-1,drawStyle:T,maxWord:o,wordIdx:i-f,gridCell:a,referenceSequence:P,maxLengthOfMonomer:d,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(M)||M<1?void 0:M-f};(0,h.oZ)(e,c,t+this.padding+this._leftThreeDotsPadding,n,r,s,m)}if(this.shouldRenderShiftedThreeDots(f)){const i={color:y,pivot:0,left:!0,transparencyRate:0,separator:E,last:!1,drawStyle:T,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:d,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,h.oZ)(e,"...",t+this.padding,n,r,s,i)}}}catch(e){const[t,n]=(0,d.AP)(e);this.logger.error(t,void 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l,u,d;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(l||(l={})),function(e){e.applyToBackground=".m.cellRenderer.applyToBackground"}(u||(u={})),function(e){e.MSA="MSA",e.classic="classic"}(d||(d={}));const h=new class{constructor(){this.color=s,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=d.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(e,t,n,o,l,u,p){var m,f,g;const y={...h,...p};if(y.isMultiLineContext){e.textBaseline="middle",e.textAlign="center";let r=t;null!=y.maxLengthOfMonomer&&(r=c(r,y.maxLengthOfMonomer));const i=Math.max(.1,1-(y.transparencyRate??0));e.globalAlpha=i;const d=e.measureText(r),h=d.fontBoundingBoxAscent+d.fontBoundingBoxDescent,p=o+(u-h)/2+d.fontBoundingBoxAscent;let m=y.color??s;return m&&m!==s||(m=a),e.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(e.save(),e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n,o,l,u),e.restore(),e.fillStyle=m),e.fillText(r,n+l/2,p),e.globalAlpha=1,e.textBaseline="top",e.textAlign="start",n+l}p.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let b=t.substring(0),w=y.last?"":y.separator;y.drawStyle===d.MSA&&(w="");let v=!0,A=!0,E="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(v=y.gridCell.cell.column.temp["color-code"]??!0,A=y.gridCell.cell.column.temp["compare-with-current"]??!0,E=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const e=y.referenceSequence[y.wordIdx];A&&y.referenceSequence.length>0&&"difference"===E&&(y.transparencyRate=b==e?.7:y.transparencyRate),A&&y.referenceSequence.length>0&&"equal"===E&&(y.transparencyRate=b!=e?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=c(b,y.maxLengthOfMonomer));const C=b+w;(m=y.monomerTextSizeMap)[C]??(m[C]=e.measureText(C));let T=y.monomerTextSizeMap[C];(f=y.monomerTextSizeMap)[b]??(f[b]=e.measureText(b));let S=y.monomerTextSizeMap[b].width;const _=u/2-(T.fontBoundingBoxAscent+T.fontBoundingBoxDescent)/2+1;(g=y.monomerTextSizeMap)[w]??(g[w]=e.measureText(w));const P=y.monomerTextSizeMap[w].width;function M(t,s){let c=v?y.color:a;y.selectedPosition===y.wordIdx+1&&(e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n+t-4,o-5,y.monomerTextSizeMap[b].width+8,u+10),c=r.Color.toHtml(r.Color.setAlpha(r.Color.fromHtml(c),255))),e.fillStyle=c,e.globalAlpha=1-y.transparencyRate,y.drawStyle===d.classic&&(e.fillText(b,n+t,o+_),e.fillStyle=i,e.fillText(w,n+s,o+_)),y.drawStyle===d.MSA&&e.fillText(b,n+t,o+_),e.globalAlpha=1}T=T.width,y.drawStyle===d.MSA&&(S=y.maxWord[y.wordIdx],T=y.maxWord[y.wordIdx]);const x=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||T>l)return M(x,x+S),n+x+S+P;{const e=(l-T)/2;return M(e,e+S),n+x+e+S}}},6307:(e,t,n)=>{"use 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s().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:w}))).toArray()})).toArray();for(let e=0;e<m;e++){const n=g[e],i=Math.floor(e*f),s=e===m-1?d:Math.floor((e+1)*f);y[e]=new Promise((e=>{n.onmessage=t=>{e(t.data)}})),n.postMessage({seqList:v,monomersDict:t,alphabet:o,polymerType:l,start:i,end:s})}const A=[],C=[];await Promise.all(y).then((e=>{for(const t of e)A.push(...t.molfiles),C.push(...t.warnings)})),setTimeout((()=>{g.forEach((e=>{e.terminate()}))}),0);const T=(0,r.qj)(p,e.name),S=i.Column.fromType(i.COLUMN_TYPE.STRING,T,e.length).init((e=>A[e]?.molfile));return S.semType=i.SEMTYPE.MOLECULE,S.meta.units=i.UNITS.Molecule.MOLBLOCK,S.setTag(".sequence-src-col",e.name),{molCol:S,warnings:C}}function c(e,t){const n={},o={};for(const s of e){const e=t.getWebEditorMonomer(s.biotype,s.symbol).backgroundcolor,a=(0,r.vG)(e??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const e of s.atoms)n[e]=a;for(const e of 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A={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},C={sugar:w,phosphate:v,seqLength:e.length,atomCount:c,bondCount:h},T=new o.Cg,S=[];let E,M=0;for(A.i=0;A.i<C.seqLength;++A.i){const n=e[A.i];if(n.symbol===r._S)continue;const i=(0,o.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)});E=i.terminalR2Atom;const s=A.nodeShift,l=A.bondShift;b(i,f,y,A,C),i.stereoAtoms?.forEach((e=>S.push(e+M))),M+=i.atoms.x.length;const c=A.nodeShift-s,u=new Array(c);for(let e=0;e<c;++e)u[e]=s+e;const h=A.bondShift-l,d=new Array(h);for(let e=0;e<h;++e)d[e]=l+e;T.set(A.i,{biotype:n.biotype,symbol:n.symbol,atoms:u,bonds:d})}p&&function(e,t,n,o,s=i.u.OXYGEN){const r=n.nodeShift+1;e[o.atomCount]=i.u.V3K_BEGIN_DATA_LINE+r+" "+(s??i.u.OXYGEN)+" "+g(n.backbonePositionShift[0])+" "+n.flipFactor*g(n.backbonePositionShift[1])+" 0.000000 0\n";const a=n.backboneAttachNode,l=r;t[o.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+a+" "+l+"\n"}(f,y,A,C,E??i.u.OXYGEN);const x=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+h+i.u.V3K_COUNTS_LINE_ENDING;let L="";return L+=i.u.V3K_HEADER_FIRST_LINE,L+=i.u.V3K_HEADER_SECOND_LINE,L+=i.u.V3K_BEGIN_CTAB_BLOCK,L+=x,L+=i.u.V3K_BEGIN_ATOM_BLOCK,L+=f.join(""),L+=i.u.V3K_END_ATOM_BLOCK,L+=i.u.V3K_BEGIN_BOND_BLOCK,L+=y.join(""),L+=i.u.V3K_END_BOND_BLOCK,S.length>0&&(L+=function(e){const t=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${e.length}`;for(let i=0;i<e.length;i++){const o=`${n} ${e[i]}`;o.length>76?(t.push(`${n} -\n`),n=`M  V30 ${e[i]}`):n=o,i===e.length-1&&t.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${t.join("")}M  V30 END COLLECTION\n`}(S)),L+=i.u.V3K_END_CTAB_BLOCK,L+=i.u.V3K_END,{molfile:L,monomers:T}}function u(e,t,n,i){i.flipFactor=(-1)**(i.i%2),h(e,t,n,i)}function h(e,t,n,o){!function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const s=n.nodeShift+o+1;t[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+s+" "+e.atoms.atomTypes[o]+" "+g(n.backbonePositionShift[0]+e.atoms.x[o])+" "+g(n.backbonePositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}}(e,t,o),p(e,n,o),function(e,t,n){if(0!==n.backboneAttachNode){const o=n.bondShift,s=n.backboneAttachNode,r=e.meta.terminalNodes[0]+n.nodeShift;t[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+r+"\n"}}(e,n,o),null!==e.meta.branchShift&&e.meta.terminalNodes.length>2&&function(e,t){t.branchAttachNode=t.nodeShift+e.meta.terminalNodes[2];for(let n=0;n<2;++n)t.branchPositionShift[n]=t.backbonePositionShift[n]+e.meta.branchShift[n]}(e,o),function(e,t){t.backboneAttachNode=t.nodeShift+e.meta.terminalNodes[1],t.bondShift+=e.bonds.atomPairs.length+1,t.nodeShift+=e.atoms.atomTypes.length,t.backbonePositionShift[0]+=e.meta.backboneShift?.[0]??0,t.backbonePositionShift[1]+=t.flipFactor*(e.meta.backboneShift?.[1]??0)}(e,o)}function d(e,t,n,o,s){if(0===o.i)h(s.sugar,t,n,o);else for(const e of[s.phosphate,s.sugar])h(e,t,n,o);!function(e,t,n,o){(function(e,t,n){for(let o=0;o<e.atoms.atomTypes.length;++o){const s=n.nodeShift+o+1;t[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+s+" "+e.atoms.atomTypes[o]+" "+g(n.branchPositionShift[0]+e.atoms.x[o])+" "+g(n.branchPositionShift[1]+n.flipFactor*e.atoms.y[o])+" "+e.atoms.kwargs[o]}})(e,t,o),p(e,n,o),function(e,t,n){const o=n.bondShift,s=n.branchAttachNode,r=e.meta.terminalNodes[0]+n.nodeShift;t[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+r+"\n"}(e,n,o);const s=o.bondShift,r=o.branchAttachNode,a=e.meta.terminalNodes[0]+o.nodeShift;n[s-1]=i.u.V3K_BEGIN_DATA_LINE+s+" 1 "+r+" "+a+"\n",o.bondShift+=e.bonds.atomPairs.length+1,o.nodeShift+=e.atoms.atomTypes.length}(e,t,n,o)}function p(e,t,n){for(let o=0;o<e.bonds.atomPairs.length;++o){const s=n.bondShift+o+1,r=e.bonds.atomPairs[o][0]+n.nodeShift,a=e.bonds.atomPairs[o][1]+n.nodeShift;let l="";if(e.bonds.bondConfiguration.has(o)){let t=e.bonds.bondConfiguration.get(o);n.flipFactor<0&&(t=1===t?3:1),l=" CFG="+t}const c=e.bonds.kwargs.has(o)?" "+e.bonds.kwargs.get(o):"";t[n.bondShift+o]=i.u.V3K_BEGIN_DATA_LINE+s+" "+e.bonds.bondTypes[o]+" "+r+" "+a+l+c+"\n"}}function m(e,t,n,s){let l=0,c=0,u=0,h=!0,d=null;for(const n of e)if(n.symbol!==r._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,o.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,u++}if("PEPTIDE"===s)l+=1,c+=u,u>0&&((d?.meta?.rNodes?.length??0)<2||d?.terminalR2Atom?.toLowerCase()===i.u.HYDROGEN.toLowerCase())&&(h=!1,l-=1,c-=1);else{const s=n===r.YI.DNA?(0,o.xb)(t,i.u.DEOXYRIBOSE):(0,o.xb)(t,i.u.RIBOSE),a=(0,o.xb)(t,i.u.PHOSPHATE);l+=(e.length-1)*a.atoms.x.length,l+=e.length*s.atoms.x.length,l+=1,c+=(e.length-1)*a.bonds.bondTypes.length,c+=e.length*s.bonds.bondTypes.length,c-=1,c+=3*e.length}return{atomCount:l,bondCount:c,needsCapping:h}}function g(e){return Math.round(i.u.PRECISION_FACTOR*e)/i.u.PRECISION_FACTOR}},6077:(e,t,n)=>{"use strict";n.d(t,{C4:()=>m,eM:()=>g});var i=n(4328),o=n(6082),s=n(1991),r=n.n(s),a=n(439),l=n(3561),c=n(9235),u=n(294),h=n(9192),d=n(330),p=n(8123);async function m(e,t,n,s,l){if(t.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let u=t;const p=s.getSeqHandler(t);let m,f;p.notation!==a.Hi.SEPARATOR&&(u=p.convert(a.Hi.SEPARATOR,"."),u.name=t.name);try{f=s.getSeqHandler(u).alphabet,m=(0,d.pz)(f)}catch(e){const[t,n]=(0,h.AP)(e);return{molCol:null,warnings:[t]}}const y=function(e,t){const n=e.length,o=new Array(n),s=t.getSeqHandler(e);let a=!1;const l=s.defaultBiotype;for(let e=0;e<n;++e){const t=s.getSplitted(e);a||(a=0===t.length),o[e]=r().count(0).take(t.length).filter((e=>!t.isGap(e))).map((e=>({position:e,biotype:l,symbol:t.getCanonical(e)}))).toArray()}return a&&i.shell.warning(`Some values in the "${e.name}" column are empty`),o}(u,s),b=g(y,m,f,n,l),w=u.length,v=await(0,c.R)(u,b,f,m,n,s,l);v.warnings.length>.05*w&&i.shell.warning(`Molfile conversion resulted in ${v.warnings.length} errors`);const A=o.Func.find({name:"convertToV3KViaOCL"})[0];if(A&&v.molCol)try{const e=v.molCol.toList(),t=await A.apply({mols:e});v.molCol.init((n=>t[n]?t[n]:e[n]))}catch(e){console.error(e)}return v}function g(e,t,n,i,o){const s=(0,l.Hb)(i,t,n),r={},c={value:null};if("RNA"===t){const e=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of e)f(r,n.symbol,s,o,t,c)}for(let n=0;n<e.length;++n){const i=e[n];for(const e of i){const n=e.symbol;if(""!==n)try{if("RNA"===t&&3===n.split(/\(|\)/).filter((e=>!!e)).length){const e=n.split(/\(|\)/)[1];f(r,e,s,o,t,c),r[t]?.[e]&&(r[t][n]=r[t][e])}else f(r,n,s,o,t,c)}catch(e){const t=e instanceof Error?e.message:e.toString(),i=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${t}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${t}`)}}}return r}function f(e,t,n,i,o,s){const r={polymerType:o,symbol:t};if(!(0,u.bq)(e,r)){const a=function(e,t,n,i,o){if(t.has(e)){const r=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,"").replace("OH","O").replace("Oh","O"),t.push(e)}return t}(r.rgroups),c=(s=r.molfile).includes("V3000")?function(e){const t=new Map,n=/M  V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(e));)i.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(i[1]),parseInt(i[3]));return t}(s):function(e){const t=new Map;let n=e.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=e.indexOf("\n",n);const o=parseInt(e.substring(n,i).replace(/^A\s+/,""));n=e.indexOf("R",i),i=e.indexOf("\n",n);const s=parseInt(e.substring(n,i).replace(/^R/,""));t.set(o,s),n=e.indexOf(p.u.V2K_A_LINE,i)}for(n=e.indexOf(p.u.V2K_RGP_LINE,0),i=e.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=e.indexOf("\n",n);const o=e.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<o.length;e+=2){if(t.has(o[e])&&t.get(o[e])!==o[e+1])throw new Error(`r-group index ${o[e]} has already been added with a different value`);t.set(o[e],o[e+1])}n=e.indexOf(p.u.V2K_RGP_LINE,i)}return t}(s),u=r.molfile.includes("V3000")?r.molfile:function(e,t){const n=t.get_mol(function(e){return e.split("\n").map((e=>{const t=e.indexOf(" R#  "),n=e.indexOf(" R   ");if(-1===t&&-1===n)return e;const i=-1!==t?t:n,o=e.split("");for(let e=i+5;e<o.length;e++)" "!==o[e]&&(o[e]="0");return o.join("")})).join("\n")}(e)),i=n.get_v3Kmolblock();return n.delete(),i}(function(e){let t=e.indexOf(p.u.V2K_A_LINE,0);-1===t&&(t=e.indexOf(p.u.V2K_RGP_LINE));const n=e.indexOf(p.u.V3K_END,t);return e.substring(0,t)+e.substring(n)}(r.molfile),n),h=function(e){let t=(e=e.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const i=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:i,bondCount:parseInt(e.substring(t,n))}}(u),d=function(e,t){const n=new Array(t),i=new Float32Array(t),o=new Float32Array(t),s=new Array(t);let r=e.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);r=e.indexOf("\n",r);let a=r;for(let l=0;l<t;l++){r=e.indexOf(p.u.V3K_BEGIN_DATA_LINE,r)+p.u.V3K_IDX_SHIFT,a=e.indexOf(" ",r),r=a+1,a=e.indexOf(" ",r),n[l]=e.substring(r,a);const t=new Array(2);for(let n=0;n<2;++n)r=a+1,a=e.indexOf(" ",r),t[n]=parseFloat(e.substring(r,a));i[l]=t[0],o[l]=t[1],r=a,a=e.indexOf("\n",r)+1,s[l]=e.slice(r,a),r=a}return{atomTypes:n,x:i,y:o,kwargs:s}}(u,h.atomCount),m=function(e,t){const n=new Uint32Array(t),i=new Array(t),o=new Map,s=new Map;let r=e.indexOf(p.u.V3K_BEGIN_BOND_BLOCK);r=e.indexOf("\n",r);let a=r;for(let l=0;l<t;++l){const 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u=e.x.reduce(((t,n,i)=>{if(i===r)return t;if(i===c)return t;const o=e.y[i];return Math.sqrt((n-a)**2+(o-l)**2)>Math.sqrt((e.x[t]-a)**2+(e.y[t]-l)**2)?i:t}),-1);if(-1===u&&(u=e.x.length,e.x=new Float32Array([...e.x,-a]),e.y=new Float32Array([...e.y,-l]),e.atomTypes=[...e.atomTypes,"H"],e.kwargs=[...e.kwargs,""],t.atomPairs.push([c+1,u+1]),t.bondTypes=new Uint32Array([...t.bondTypes,1]),t.kwargs.set(t.atomPairs.length-1,"")),i.set(u+1,o),1===o)n.unshift(e.atomTypes[u]);else{if(2!==o)throw new Error(`Unexpected missing R-group: ${o}`);n.splice(1,0,e.atomTypes[u])}}return function(e,t,n){for(const[i,o]of n)e.atomTypes[i-1]=t[o-1]}(e,n,i),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const i of[1,2])if(e.get(t.rNodes[n])===i){const e=t.rNodes[i-1];t.rNodes[i-1]=t.rNodes[n],t.rNodes[n]=e}}(i,o),y(t,o),o}(d,m,a,c),f=function(e){let t=[],n=e.indexOf("M  V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const 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Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const e=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter((t=>t.args.source===this.tableCol&&e.includes(t.args.key)))),200).subscribe((e=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(f.filter((e=>e.args.source===this.tableCol&&e.args.key===l.gp.positionShift))),200).subscribe((e=>{this.reset()})))}}calculateFontBasedSpacing(e){const t=e.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const e=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof e||isNaN(e)||(n=Math.max(e,1))}return{lineHeight:Math.max(1.4*n,t.fontBoundingBoxAscent+t.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(e){return"true"===e.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(e,t,n,i,o,s){if(this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const{lineHeight:r,monomerSpacing:a}=this.calculateFontBasedSpacing(e),l=t-2*this.padding;let c=0;const u=[];if(i.length>0)for(let t=o;t<i.length;t++){const n=i.getOriginal(t),o=this.props.monomerToShort(n,s);u.push({text:o,posIdx:t}),c=Math.max(c,e.measureText(o).width)}if(0===u.length)return{lineLayouts:[],lineHeight:r};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,g=Math.max(0,Math.floor(m/r)),f=[];let y=0;for(let e=0;e<g&&y<u.length;e++){const t=[];for(let e=0;e<p&&y<u.length;e++){const n=u[y],i=this.padding+e*(d+a);t.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}f.push({lineIdx:e,elements:t})}return{lineLayouts:f,lineHeight:r}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,u.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=this.padding;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,s=Math.ceil(t/i)+o,r=n.splitter(e),a=Math.min(s,r.length),l=new Array(a-o);let c=0;for(let e=o;e<a;++e){const i=r.getOriginal(e),s=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(l[e-o]=a,c+=a,c>t)break}return l}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+t,s=n.getSplitted(e),r=Math.min(o,s.length);let a=this._monomerLengthList[e];if(null===a||a.length!=r-t){a=this._monomerLengthList[e]=new Array(s.length);let i=0;for(let e=t;e<r;++e){const o=s.getOriginal(e),r=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(a[e-t]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,s=this.positionShift,r=Math.ceil(this.colWidth/o)+s;for(let e=n;e<i;e++){if(this._processedRows.get(e)&&r<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,r),i=Math.min(r,n.length);i-s>t.length&&t.push(...new Array(i-s-t.length).fill(o));let a=0;for(let e=s;e<i;++e){const i=n.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),r=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(t[e-s]=Math.max(t[e-s]??0,r),a+=r,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,r),this._processedRows.set(e,!0)}return t}getPosition(e,t,n,i){const[o,s]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:b(s,t,i)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}get positionShift(){const e=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(e)?0:Math.max(e,0)}render(e,t,n,i,s,a,c){const u=a.grid?.canvas===e.canvas;if(!this.seqHelper)return;const m=this.tableCol,g=this.positionShift;e.save();try{const c=this.seqHelper.getSeqHandler(m);let h=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));h=!isNaN(e)&&e?e:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=h){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(h),this.setSeparatorWidth(c.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const f=a.cell.rowIndex,b=a.cell.value;u&&(i=v(a.grid,e,t,i,window.devicePixelRatio)),e.beginPath(),e.rect(t,n,i,s),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const w=m.meta.units,A=m.getTag(l.gp.aligned),C=m.getTag(l.gp.separator)??"",T=u?c.getSplitted(f):c.splitter(b);let S=d.yg.classic;A?.includes("MSA")&&w===l.Hi.SEPARATOR&&(S=d.yg.MSA);const E=m.temp["reference-sequence"],M=this.tableCol.temp["current-word"],x=(()=>{const e=(0,c.splitter)(null!=E&&""!==E?E:M??"");return r().count(0).take(e.length).slice(g).map((t=>e.getCanonical(t))).toArray()})(),L=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const r=[],l=this.calculateMultiLineLayoutDynamic(e,i,s,T,g,h);let u=n+this.padding;1===l.lineLayouts.length&&(u=n+(s-l.lineHeight)/2);for(const i of l.lineLayouts){const s=u+i.lineIdx*l.lineHeight;for(const u of i.elements){const h=t+u.x,p=u,f=p.posIdx,b=T.getCanonical(f);let w=y;const v=this.getMonomerLib();v&&(w=v.getMonomerTextColor(c.defaultBiotype,b));let A=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&x.length>0){const e=f-g;e>=0&&e<x.length&&b===x[e]&&(A=.7)}r.push({lineIdx:i.lineIdx,monomerIdx:f-g,bounds:new o.Rect(u.x,s-n,u.width,l.lineHeight),sequencePosition:f}),(0,d.oZ)(e,p.om,h,s,u.width,l.lineHeight,{color:w,isMultiLineContext:!0,transparencyRate:A,selectedPosition:isNaN(L)||L<1?void 0:L,wordIdx:f})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,r)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(g)?e.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);u||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const r=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(T.length,Math.ceil(i/r)+g);for(let r=g;r<l;++r){const l=r<T.length?T.getOriginal(r):c.defaultGapOriginal,u=r<T.length?T.getCanonical(r):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,u));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:C,last:r===T.length-1,drawStyle:S,maxWord:o,wordIdx:r-g,gridCell:a,referenceSequence:x,maxLengthOfMonomer:h,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(L)||L<1?void 0:L-g};(0,d.oZ)(e,l,t+this.padding+this._leftThreeDotsPadding,n,i,s,m)}if(this.shouldRenderShiftedThreeDots(g)){const r={color:y,pivot:0,left:!0,transparencyRate:0,separator:C,last:!1,drawStyle:S,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:h,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(e,"...",t+this.padding,n,i,s,r)}}}catch(e){const[t,n]=(0,h.AP)(e);this.logger.error(t,void 0,n),this.errors.push(e)}finally{e.restore()}}shouldRenderShiftedThreeDots(e){return e>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(e,t){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==e.tableRowIndex)return;const o=this.positionShift,s=e.bounds,r=t.offsetX-e.gridColumn.left+(e.gridColumn.left-s.x),a=t.offsetY-s.y;this.gridCol?.grid?.canvas&&(this.gridCol.grid.canvas.style.cursor="default");let c=null;const u=this._cellBounds.get(e.tableRowIndex);if(u){for(const e of u)if(e.bounds.contains(r,a)){c=e.monomerIdx;break}}else{const t=this.shouldRenderShiftedThreeDots(o)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0;c=this.getPosition(e.tableRowIndex,r,s.width,t)}this.logger.debug(`${n}, argsX: ${r}, argsY: ${a}, left: ${c}`);const h=this.seqHelper.getSeqHandler(this.tableCol),d=h.getSplitted(e.tableRowIndex);if(null!==c&&c>=0&&c+o<d.length){const n=h.alphabet??l.YI.UN,s={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:d.getCanonical(c+o)},r=[];let a=this._monomerStructureMap[s.symbol];if(!a){const e=this.getMonomerLib();a=this._monomerStructureMap[s.symbol]=e?e.getTooltip(s.biotype,s.symbol):i.divText("Monomer library is not available")}r.push(a),i.tooltip.show(i.divV(r),t.x+16,t.y+16),(0,g.WN)(e,s)}else-1===c?i.tooltip.show(i.divText(`${Math.min(o,d.length)} hidden monomers`),t.x+16,t.y+16):i.tooltip.hide(),(0,g.WN)(e,null)}}function v(e,t,n,i,o){return e?Math.max(Math.min(e.canvas.width/o-n,i)):Math.max(t.canvas.width/o-n,0)}},3856:(e,t,n)=>{"use strict";n.d(t,{Mn:()=>u,gp:()=>c,oZ:()=>p,yg:()=>h});var i=n(6082),o=n(7278);const s="rgb(100,100,100)",r="#808080",a="rgb(0,0,0)",l=o.zS;var c,u,h;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(c||(c={})),function(e){e.applyToBackground=".m.cellRenderer.applyToBackground"}(u||(u={})),function(e){e.MSA="MSA",e.classic="classic"}(h||(h={}));const d=new class{constructor(){this.color=s,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=h.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(e,t,n,o,c,u,p){var m,g,f;const y={...d,...p};if(y.isMultiLineContext){e.textBaseline="middle",e.textAlign="center";let i=t;null!=y.maxLengthOfMonomer&&(i=l(i,y.maxLengthOfMonomer));const r=Math.max(.1,1-(y.transparencyRate??0));e.globalAlpha=r;const h=e.measureText(i),d=h.fontBoundingBoxAscent+h.fontBoundingBoxDescent,p=o+(u-d)/2+h.fontBoundingBoxAscent;let m=y.color??s;return m&&m!==s||(m=a),e.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(e.save(),e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n,o,c,u),e.restore(),e.fillStyle=m),e.fillText(i,n+c/2,p),e.globalAlpha=1,e.textBaseline="top",e.textAlign="start",n+c}p.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let b=t.substring(0),w=y.last?"":y.separator;y.drawStyle===h.MSA&&(w="");let v=!0,A=!0,C="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(v=y.gridCell.cell.column.temp["color-code"]??!0,A=y.gridCell.cell.column.temp["compare-with-current"]??!0,C=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const e=y.referenceSequence[y.wordIdx];A&&y.referenceSequence.length>0&&"difference"===C&&(y.transparencyRate=b==e?.7:y.transparencyRate),A&&y.referenceSequence.length>0&&"equal"===C&&(y.transparencyRate=b!=e?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=l(b,y.maxLengthOfMonomer));const T=b+w;(m=y.monomerTextSizeMap)[T]??(m[T]=e.measureText(T));let S=y.monomerTextSizeMap[T];(g=y.monomerTextSizeMap)[b]??(g[b]=e.measureText(b));let E=y.monomerTextSizeMap[b].width;const M=u/2-(S.fontBoundingBoxAscent+S.fontBoundingBoxDescent)/2+1;(f=y.monomerTextSizeMap)[w]??(f[w]=e.measureText(w));const x=y.monomerTextSizeMap[w].width;function L(t,s){let l=v?y.color:a;y.selectedPosition===y.wordIdx+1&&(e.fillStyle="rgba(60, 177, 115, 0.2)",e.fillRect(n+t-4,o-5,y.monomerTextSizeMap[b].width+8,u+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),e.fillStyle=l,e.globalAlpha=1-y.transparencyRate,y.drawStyle===h.classic&&(e.fillText(b,n+t,o+M),e.fillStyle=r,e.fillText(w,n+s,o+M)),y.drawStyle===h.MSA&&e.fillText(b,n+t,o+M),e.globalAlpha=1}S=S.width,y.drawStyle===h.MSA&&(E=y.maxWord[y.wordIdx],S=y.maxWord[y.wordIdx]);const _=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||S>c)return L(_,_+E),n+_+E+x;{const e=(c-S)/2;return L(e,e+E),n+_+e+E}}},6307:(e,t,n)=>{"use strict";n.d(t,{F:()=>r});var i=n(7389),o=n(6082),s=n(439);function r(e,t,n){let r=0,a=null;for(const t of Object.values(e))r+=t,a=null===a?t:Math.max(a,t);const l=a/r,c=Object.assign({},...Array.from(Object.entries(e)).sort(((e,t)=>t[1]-e[1])).map((([e,a])=>{const c=a/r;let u;try{const i=n.getMonomerColors(t,e);u=i?.backgroundcolor||"#CCCCCC"}catch(t){console.warn(`Failed to get colors for monomer ${e}:`,t),u="#CCCCCC"}const h=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});h.style.width=50*c/l+"px",h.style.backgroundColor=u,s._S===e&&(h.style.borderWidth="1px",h.style.borderStyle="solid",h.style.borderColor=o.Color.toHtml(o.Color.lightGray));const d=s._S===e?"-":e,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([h,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),u=i.tableFromMap(c);return Array.from(u.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),u}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>l,Ec:()=>s,f6:()=>i,pe:()=>r,q7:()=>a,yw:()=>o});const i=["symbol","molfile","rgroups","name"],o="MonomerName",s={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},r={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(e,t,n)=>{"use strict";function i(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function o(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?o(e.$thrownJsError):void 0}function s(e){return[i(e),o(e)]}n.d(t,{AP:()=>s})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>s});var i=n(6082),o=n(439);class s{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const i=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=i.Column.fromStrings("description",this.descriptionsArray),t=i.Column.fromStrings("sequence",this.sequencesArray);return t.semType=i.SEMTYPE.MACROMOLECULE,t.meta.units=o.Hi.FASTA,[i.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>h,dW:()=>u,fD:()=>c});var i=n(6082),o=n(1991),s=n.n(o),r=n(2003),a=n(7278),l=n(439);function c(){const e=[];return e.push(i.Column.fromList("string","MSA",new Array(10**6).fill("meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"))),e.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(10**6).fill(5.30751))),e}function u(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=r.Hi.SEPARATOR,n.setTag(r.gp.separator,"/"),n.setTag(r.gp.alphabet,r.YI.UN),n.setTag(r.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function h(e,t=r.Hi.SEPARATOR,n=r.YI.PT,o=(t===r.Hi.SEPARATOR?"-":void 0),c=void 0,u="seq",h=100,d=10**6){const 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n=n.next,{done:!1,value:e}})):$.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,r){if(0!==t.size)for(var o,s,i="mixed"!==n&&n!==t.type,a="undirected"===n,c=!1,l=t._edges.values();!0!==(o=l.next()).done;)if(s=o.value,!i||s.undirected===a){var u=s,d=u.key,h=u.attributes,p=u.source,m=u.target;if(c=r(d,h,p.key,m.key,p.attributes,m.attributes,s.undirected),e&&c)return d}}function ce(e,t,n,r,o,s){var i,a=t?ne:te;if("undirected"!==n){if("out"!==r&&(i=a(e,o.in,s),e&&i))return i;if("in"!==r&&(i=a(e,o.out,s,r?void 0:o.key),e&&i))return i}if("directed"!==n&&(i=a(e,o.undirected,s),e&&i))return i}function le(e,t,n,r,o,s,i){var a,c=n?se:oe;if("undirected"!==t){if(void 0!==o.in&&"out"!==r&&(a=c(e,o.in,s,i),e&&a))return a;if(void 0!==o.out&&"in"!==r&&(r||o.key!==s)&&(a=c(e,o.out,s,i),e&&a))return a}if("directed"!==t&&void 0!==o.undirected&&(a=c(e,o.undirected,s,i),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function de(){this.A=null,this.B=null}function he(e,t,n,r,o){for(var s in r){var i=r[s],a=i.source,c=i.target,l=a===n?c:a;if(!t||!t.has(l.key)){var u=o(l.key,l.attributes);if(e&&u)return l.key}}}function pe(e,t,n,r,o){if("mixed"!==t){if("undirected"===t)return he(e,null,r,r.undirected,o);if("string"==typeof n)return he(e,null,r,r[n],o)}var s,i=new de;if("undirected"!==t){if("out"!==n){if(s=he(e,null,r,r.in,o),e&&s)return s;i.wrap(r.in)}if("in"!==n){if(s=he(e,i,r,r.out,o),e&&s)return s;i.wrap(r.out)}}if("directed"!==t&&(s=he(e,i,r,r.undirected,o),e&&s))return s}function me(e,t,n){var r=Object.keys(n),o=r.length,s=0;return new $((function(){var i=null;do{if(s>=o)return e&&e.wrap(n),{done:!0};var a=n[r[s++]],c=a.source,l=a.target;i=c===t?l:c,e&&e.has(i.key)&&(i=null)}while(null===i);return{done:!1,value:{neighbor:i.key,attributes:i.attributes}}}))}function fe(e,t,n,r,o){for(var s,i,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(s=h.next()).done;){var m=!1;if(i=s.value,"undirected"!==p)for(a in c=i.out){l=c[a];do{if(u=l.target,m=!0,d=o(i.key,u.key,i.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=i.undirected)if(!(t&&i.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=o(i.key,u.key,i.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=o(i.key,null,i.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new V('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new V("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new V("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!l(e))throw new V('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new V("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new V("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new V("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new V("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ee={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ce(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Te(e,t,n,r,o,s,i,a){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new V("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,i=""+i,a=a||{},!e.allowSelfLoops&&s===i)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(s),u=e._nodes.get(i);if(!c)throw new U("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new U("Graph.".concat(t,': target node "').concat(i,'" not found.'));var d={key:null,undirected:r,source:s,target:i,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new B("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[i]:void 0!==c.out[i]))throw new B("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(i,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,o,c,u,a);e._edges.set(o,h);var p=s===i;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=o,e.emit("edgeAdded",d),o}function Se(e,t,n,r,o,s,i,c,u){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new V("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new V("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(s=""+s,i=""+i,u&&(d=c,c=void 0),!e.allowSelfLoops&&s===i)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(s),f=e._nodes.get(i);if(!n&&(h=e._edges.get(o))){if(!(h.source.key===s&&h.target.key===i||r&&h.source.key===i&&h.target.key===s))throw new B("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(s,'" source & "').concat(i,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[i]:m.out[i]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var b={key:null,undirected:r,source:s,target:i,attributes:c};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new B("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var w=!1,v=!1;m||(m=Ce(e,s,{}),w=!0,s===i&&(f=m,v=!0)),f||(f=Ce(e,i,{}),v=!0),h=new K(r,o,m,f,c),e._edges.set(o,h);var A=s===i;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,w,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,o=t.attributes,s=t.undirected,i=n===r;s?(n.undirectedDegree--,r.undirectedDegree--,i&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,i&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:r.key,undirected:s})}var Pe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ee,e)).multi)throw new V("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new V('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new V("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?Y:"directed"===e.type?W:j;d(i(t),"NodeDataClass",r);var o="geid_"+we()+"_",s=0;return d(i(t),"_attributes",{}),d(i(t),"_nodes",new Map),d(i(t),"_edges",new Map),d(i(t),"_directedSize",0),d(i(t),"_undirectedSize",0),d(i(t),"_directedSelfLoopCount",0),d(i(t),"_undirectedSelfLoopCount",0),d(i(t),"_edgeKeyGenerator",(function(){var e;do{e=o+s++}while(t._edges.has(e));return e})),d(i(t),"_options",e),Ae.forEach((function(e){return d(i(t),e,t[e])})),h(i(t),"order",(function(){return t._nodes.size})),h(i(t),"size",(function(){return t._edges.size})),h(i(t),"directedSize",(function(){return t._directedSize})),h(i(t),"undirectedSize",(function(){return t._undirectedSize})),h(i(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(i(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(i(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(i(t),"multi",t._options.multi),h(i(t),"type",t._options.type),h(i(t),"allowSelfLoops",t._options.allowSelfLoops),h(i(t),"implementation",(function(){return"graphology"})),t}t(r,n);var o=r.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new V("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},o.edge=function(e,t){if(this.multi)throw new B("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new U('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,o=n.target.key;if(e===r)return o;if(e===o)return r;throw new U('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new U('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new V('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new B('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!l(t))throw new V('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new V('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new U('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new U('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new U('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new U('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new U('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new V("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!l(e))throw new V("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!l(e))throw new V("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new V("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,o=this._nodes.values();!0!==(n=o.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,o,s,i=this._edges.values();!0!==(n=i.next()).done;)o=(r=n.value).source,s=r.target,r.attributes=e(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new V("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new V("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new V("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),o=new Array(this.order),s=0;!0!==(t=r.next()).done;)n=t.value,o[s++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new V("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new V("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new V("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),o=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new V("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new V("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,o=t,s=this._nodes.values();!0!==(n=s.next()).done;)o=e(o,(r=n.value).key,r.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new $((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,o){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,o,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},o.import=function(e){var t,n,o,s,i,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,o,s,i){c?i?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):i?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new V("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new V("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new V("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){ge(s=o[t]);var u=s,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new V("Graph.import: invalid edges. 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c=n(1858),l=n(5072),u=n.n(l),d=n(7825),h=n.n(d),p=n(7659),m=n.n(p),f=n(5056),g=n.n(f),y=n(540),b=n.n(y),w=n(1113),v=n.n(w),A=n(7939),E={};E.styleTagTransform=v(),E.setAttributes=g(),E.insert=m().bind(null,"head"),E.domAPI=h(),E.insertStyleElement=b(),u()(A.A,E),A.A&&A.A.locals&&A.A.locals,n(2780),Promise.resolve(),n(934),n(8903);var C=n(1991),T=n.n(C);a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;var S=n(9713);n(6295);var _,P,M,x,N,$,L=n(8774);(M=_||(_={})).none="none",M.bold="bold",M.dashed="dashed",(x=P||(P={})).EUCLIDEAN="EUCLIDEAN",x.MANHATTAN="MANHATTAN",P.EUCLIDEAN,P.MANHATTAN,($=N||(N={})).HAMMING="Hamming",$.EUCLIDEAN="Euclidean",$.VECTOR_COSINE="Vector Cosine",$.MANHATTAN="Manhattan",$.TANIMOTO="Tanimoto",$.LEVENSTEIN="Levenshtein",$.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",$.MONOMER_CHEMICAL_DISTANCE="Monomer chemical 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I,R,O,k,G,D=n(2003),H=(n(3516),n(6718),n(3077),n(439));(R=I||(I={})).IDENTITY="identity",R.SIMILARITY="similarity",n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(O||(O={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(k||(k={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(G||(G={})),Object.prototype.toString,n(6873);var F=n(4356),V=(n(6717),n(4870),n(3856),n(6882),n(7278),n(5553),n(6642)),U=n(3599);n(673),n(8312),V.sD,n(4139),new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},a.SemanticValue,D.zS,a.GridCellRenderer,a.GridCellRenderer;var B,Y,W,j,K=n(8070),q=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(B||(B={})),new class{constructor(){this.regionTypes=[B.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=q.fH.Entropy,this.filterSource=q.Fo.filterSource}},n(7602),n(250),function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(Y||(Y={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(W||(W={})),a.JsViewer,n(6863),n(4954),a.JsViewer,H.b9[H.Hi.FASTA],n(5433),n(3890),n(1687),function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(j||(j={}));class z{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const r=this.isWhitespace(n)?t:t-1;for(let e=0;e<r;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToAtomType(n),t[r]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let r=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){r=this.shiftIdxToXColumn(r);for(const s of[e,t,n])s[o]=this.parseFloatValue(r),r=this.getNextColumnIdx(r);r=this.getNextLineIdx(r)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const r=new Uint16Array(2);r[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),r[1]=this.parseIntValue(t),e[n]=r,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToBondType(n),t[r]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Z extends z{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let r=0;r<t;r++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class X extends Z{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(j.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,r]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,r)}}));const n=t.map(((e,t)=>{if(e.startsWith(j.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),r=n.map((e=>t[e])),o=n.map((e=>t[e+1]));r.forEach(((t,n)=>{const r=parseInt(t.split(/\s+/)[1])-1,s=parseInt(o[n].substring(1));if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,r)}));const s=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==s.length)throw new Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(j.TYPE)&&-1!==e.indexOf(j.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,j.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<j.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,j.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,j.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+j.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=j.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Q extends Z{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class J{constructor(){}static getInstance(e){if(J.isMolfileV2K(e))return new X(e);if(J.isMolfileV3K(e))return new Q(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return X.isValidMolfile(e)}static isMolfileV3K(e){return Q.isValidMolfile(e)}}var ee=n(6197),te=n(9124),ne=n(3527),re=n(3629);class oe{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",r=void 0,o=void 0,s=void 0,i){if(this.biotype=e,this.id=t,this.n=n,this.m=r,this.type=o,this.mt=s,this.smiles=i,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++oe.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class se extends oe{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class ie extends oe{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class ae extends oe{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class ce extends oe{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class le{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,r,o,s,i,a){this.id=e,this.m=t,this.n=n,this.na=r,this.type=o,this.mt=s,this.at=i,this.smiles=a}static fromMonomer(e,t,n){let r={};const o=t.symbol,s=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{r[e.label]=e.capGroupName}));else{if(!s){if(t.lib)return new ce(e,o);throw new Error("Unexpected missing monomer without .lib")}r=n.getRS(s)}const i=new le(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,r),a=n.getMonomerColors(e,t.symbol);return a&&(i.textcolor=a?.textcolor,i.linecolor=a?.linecolor,i.backgroundcolor=a?.backgroundcolor),i}}const ue={[U.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[U.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[U.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[U.o.CHEM]:{R:"#eeeeee"},[U.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},de=/[\w()]+/,he=RegExp(String.raw`\(${de}(,${de})+\)`),pe=e=>{const t=i.canvas(250,250);return s.chem.canvasMol(0,0,250,250,t,e),t},me=new ne.Mi([255,255,255]),fe=new ne.Mi([0,0,0]),ge=.7*(0,re.wQ)(me);class ye{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length));for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t==H._S||t===H.b9[H.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:T().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{je.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}getWebEditorMonomer(e,t){const[n,r]=(0,te.fA)(e,t),o=(0,ee.Y)(n);let s=this.getMonomer(o,r);if(s&&n==U.o.LINKER&&2!=s.rgroups.length)return null;if(s&&n==U.o.SUGAR&&3!=s.rgroups.length)return null;s||(s=this.addMissingMonomer(o,r));let i=s.wem??null;return i||(r===H._S||"*"==r?i=s.wem=new se(n):n===U.o.NUCLEOTIDE&&"N"===r||n===U.o.AA&&"X"===r||(U.o.CHEM,0)||he.test(r)?i=s.wem=new ie(n,r):s.lib||(i=s.wem=new ae(n,r,this.isEmpty)),i||(i=s.wem=le.fromMonomer(n,s,this))),i}getTooltip(e,t){const n=(0,ee.Y)(e),r=i.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let c;if(r.append(i.divH([i.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),i.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),c=s.molfile?pe(s.molfile):s.smiles?i.divV([pe(s.smiles),i.divText("from smiles",{style:{fontSize:"smaller"}})]):i.divText("No structure",{style:{margin:"6px"}}),r.append(i.div(c,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=H._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),r.append(i.divText(e))):r.append(i.divText("Missed in libraries"))}}else r.append(i.divV([i.divText(`Monomer '${t}' of type '${n}' not found.`),i.divText("Open the Context Panel, then expand Manage Libraries")]));return r}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),r=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=r(n.textcolor),s=new ne.Mi([...o.map((e=>e+1))]),i=(0,re.KE)(s,me)/((0,re.wQ)(s)*(0,re.wQ)(me)),c=r(n.backgroundcolor),l=new ne.Mi([...c.map((e=>e+.01))]);let u;u=(0,re.KE)(l,me)/((0,re.wQ)(l)*(0,re.wQ)(me))<i?c:o;let d=new ne.Mi(u);const h=(0,re.wQ)(d);return h>ge&&(d=(0,re.dC)(fe,d,ge/h)),`rgb(${d[0]}, ${d[1]}, ${d[2]})`}getMonomerColors(e,t){const n="default";let r=n;const o=(0,ee.Y)(e),s=this.getMonomer(o,t);let i;if(s){if(s.meta&&s.meta.colors){const e=s.meta.colors;n in e||(r="default"),i=e[r]}if(!i){const t=ue[e],n=t?.[s.symbol];n&&(i={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=s.naturalAnalog;if(!i&&t)return this.getMonomerColors(e,t)}return i||(i={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:i.text??i.textColor,linecolor:i.line??i.lineColor,backgroundcolor:i.background??i.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let r,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){r=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+r]=o,o=""}return n}}var be=n(5488),we={};we.styleTagTransform=v(),we.setAttributes=g(),we.insert=m().bind(null,"head"),we.domAPI=h(),we.insertStyleElement=b(),u()(be.A,we),be.A&&be.A.locals&&be.A.locals;class ve extends ye{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?.[n]??null}else{je.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=(0,ee.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=J.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,F.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const o=e.duplicateMonomerPreferences[n][r],s=this.duplicateMonomers[n][r].find((e=>e.lib?.source===o));s?this._monomers[n][r]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of T().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}static overrideCounter=0;override(e,t){return new Ae(e,`override: ${++ve.overrideCounter}, ${t}`,this)}}class Ae extends ye{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Ee=n(9192);class Ce{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,o){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,Ee.AP)(e);this.error=t,this.monomers=[]}}}class Te{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var Se=n(7433),_e=n.n(Se),Pe=n(1913),Me=n.n(Pe);class xe{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(_e())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Me()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${o.polymerType??""}-${e}`;r.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(s)}return n}}var Ne=n(8604);class $e{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,r){let o;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r;let s=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((e=>o=e))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),s||(s=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++$e.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await s.dapi.files.readAsText(Ne.gt),o=JSON.parse(r),i=new xe(o);return new $e(i,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(Ne.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(Ne.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(Ne.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(Ne.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(Ne.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),o=await r.readAsText(t);n=JSON.parse(o);const s={},i=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;i.includes(t)||(s[t]={},i.push(t)),s[t][n]=e})),new ve(s,t)}async loadSetFromFile(e,t,n){let r={};const o=new a.FileSource(t),s=await o.readAsText(n);r=JSON.parse(s);const i=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,o=n.polymerType,s=n.monomerType,i=n.set;return new Ce(e,r,o,s,i)}));return new Te(i,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(Ne.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),await this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${Ne.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return je.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{je.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void je.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(Ne.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),je.logger.debug(`${e}, OUT`)})),je.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(Ne.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Ne.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(Ne.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Ne.Es.length)))}}class Le{constructor(){}static _instance;static getInstance(){return Le._instance||(Le._instance=new Le),Le._instance}_libFilesUpdateSubject$=new c.BehaviorSubject([]);_setFilesUpdateSubject$=new c.BehaviorSubject([]);_addLibraryFilesSubject$=new c.Subject;_librarySelectionSubject$=new c.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,S.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Ie{logger;_monomerLib=new ve({},"MAIN");_monomerSets=new Te("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,K.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Ie.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Ie.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await $e.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,F.ub)()]),o=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let s=0;const i=o.length,[a]=await Promise.all([Promise.all(o.map((e=>this.readLibrary(Ne.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new ve({},e,n)})).finally((()=>{n.update(Math.round(100*++s/i),`Loading monomers ${s}/${i}`)})))))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let r=0;const o=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(Ne.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new Te("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/o),`Loading monomers ${r}/${o}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,F.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,F.Eu)(n)}async getInvalidFileNames(e){const t=(await 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Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),new L.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),new L.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),new L.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),new L.A(new 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ke,Ge=n(857),De={};De.styleTagTransform=v(),De.setAttributes=g(),De.insert=m().bind(null,"head"),De.domAPI=h(),De.insertStyleElement=b(),u()(Ge.A,De),Ge.A&&Ge.A.locals&&Ge.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(ke||(ke={})),ke.MONOMER,a.COLUMN_TYPE.STRING,ke.SYMBOL,a.COLUMN_TYPE.STRING,ke.NAME,a.COLUMN_TYPE.STRING,ke.R_GROUPS,a.COLUMN_TYPE.STRING,ke.MONOMER_TYPE,a.COLUMN_TYPE.STRING,ke.POLYMER_TYPE,a.COLUMN_TYPE.STRING,ke.NATURAL_ANALOG,a.COLUMN_TYPE.STRING,ke.AUTHOR,a.COLUMN_TYPE.STRING,ke.CREATE_DATE,a.COLUMN_TYPE.DATE_TIME,ke.ID,a.COLUMN_TYPE.INT,ke.META,a.COLUMN_TYPE.STRING,ke.SOURCE,a.COLUMN_TYPE.STRING;var He,Fe=function(e,t,n,r){return new(n||(n=Promise))((function(o,s){function i(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(i,a)}c((r=r.apply(e,t||[])).next())}))};class Ve{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],r=i.breadcrumbs(n);if(r.onPathClick.subscribe((e=>Fe(this,void 0,void 0,(function*(){const t=e[e.length-1];if(t===r.path[r.path.length-1])return;const n=s.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find((e=>e.text===t))})))),s.shell.v){if(0!==r.path.length&&"Home"===r.path[0]){const e=i.iconFA("home",(()=>{s.shell.v.close(),s.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));e.classList.add("demo-breadcrumbs-home-element"),r.root.firstElementChild.replaceWith(e)}const e=null===(t=s.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(r.root))}}constructor(e,t,n=!1,r){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._stopStartBtn=i.button(i.iconFA("pause"),(()=>Fe(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=i.button(i.iconFA("redo"),(()=>Fe(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=i.button(i.iconFA("play"),(()=>Fe(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._closeBtn=i.button(i.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==r?void 0:r.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==r?void 0:r.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,Ve.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=i.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(i.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=i.iconFA("clock");this._isAutomatic||0===t&&(n=i.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const r=i.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=i.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description 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n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],r=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];r.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const c=n,l=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,c.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,r,l),yield(0,K.cb)(l));const u=i.iconFA("check");if(r.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of 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Array(y).fill(null);for(const e of v){if(!e||0===e.length)continue;const t=(await p(g.id,e,r,c,u,m)).Alignment;for(const e of t)E[parseInt(e.ID)]=Object.entries(e).filter((e=>!d.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.J.SEPARATOR)}const C=o.Column.fromStrings(n,E);return C.meta.units=s.Hi.SEPARATOR,C.setTag(s.gp.separator,a.J.SEPARATOR),C.setTag(s.gp.aligned,"SEQ.MSA"),C.setTag(s.gp.alphabet,s.YI.UN),C.setTag(s.gp.alphabetIsMultichar,"true"),C.semType=o.SEMTYPE.MACROMOLECULE,C}async function p(e,t,n,o,s,i){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},l=`/align?method=${n}&gap_open=${o}&gap_extend=${s}`,u=window.performance.now(),d=await r.dapi.docker.dockerContainers.fetchProxy(e,l,a),h=window.performance.now();c._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${h-u} ms`);const p="application/json"===d.headers.get("content-type");if(!d.ok&&p){const e=await d.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(d.statusText)}if(!d.ok&&!p){const e=await d.text();throw new Error(`Error: ${e}`)}if(!p){const e=await d.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const m=await d.json();if("pepsea-stderr"in m){const e=m["pepsea-stderr"];i?.warning(e)}return m}},3890:(e,t,n)=>{"use strict";n.d(t,{aS:()=>a,wz:()=>i}),n(6082),n(7389),n(4328);var r=n(1991),o=n.n(r);n(6723);const s=60;function i(e,t,n=s,r="\n"){const o=[];for(let s=0;s<t.length;s++){const i=e.map((e=>e.get(s).toString())).join("|"),c=a(t.getSplitted(s),n);o.push(`>${i}${r}`);for(const e of c)o.push(`${e}${r}`)}return"".concat(...o)}function a(e,t=s){let n=0;const r=e.length,i=[];for(;n<r;){const r=o().count(n).take(Math.min(e.length-n,t)).map((t=>e.getOriginal(t))).toArray(),s=r.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");i.push(s),n+=r.length}return i}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var r=n(4328),o=n(6077),s=n(2003),i=n(8312),a=n(5553),c=n(966),l=n(330);async function u(e,t,n,u,d,h,p){let m;if(n){const n=await(0,i.Q)(),r=n.getSeqHandler(t);let o,a;r.isHelm()?o=t:(a=t.name,t.name=`__${a}`,o=r.convert(s.Hi.HELM),o.name=a,e.columns.add(o,!1));try{m=await n.helmToAtomicLevel(o,!0,!0,d)}finally{o!==t&&(e.columns.remove(o.name),t.name=a)}}else{if(!(0,c.l)(t,"To Atomic Level",h)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,o.C4)(e,t,d,h,p)}if(m.molCol){const o=(0,l.qj)(e,t.name);m.molCol.name=o,e.columns.add(m.molCol,!0),await(0,a.Qc)(t,m.molCol,d,h,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await r.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";function r(e,t){e.innerHTML="",e.append(t)}function o(e,t,n,r,o){const s=()=>{const o=e.col(t);o&&(o.width=n),r&&(e.props.rowHeight=r)};if(o)return void s();const i=e.onAfterDrawOverlay.subscribe((()=>{i.unsubscribe(),setTimeout((()=>{s()}))}))}n.d(t,{Kd:()=>o,Ku:()=>r}),n(4328),n(6082)},250:(e,t,n)=>{"use strict";n.d(t,{VN:()=>m,n5:()=>l,Ue:()=>p,Tc:()=>h,eN:()=>f}),n(4328),n(7389);var r=n(6082),o=(n(1757),n(1991),n(1858),n(2003)),s=n(4326);n(8070),n(7602);var i=n(439),a=n(6882);n(6723);var c,l,u,d=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class h{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class p{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,r){this.pos=e,this.name=t,this._freqs=n??{},r?.sumRowCount&&(this.sumRowCount=r.sumRowCount),r?.sumValueForHeight&&(this.sumPlotValue=r.sumValueForHeight),r?.label&&(this._label=r.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new h),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===s.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const r=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-r*Math.log2(r)}}else if(e===s.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,o,a,c,l,u,d){const h=o===s.fH.Entropy?n*(a-this.sumPlotValueForHeight)/a:n;let p=d*u+(n-h-1);const m=Object.entries(this._freqs).sort(((e,t)=>e[0]!==i._S&&t[0]!==i._S?t[1].value-e[1].value:e[0]===i._S&&t[0]===i._S?0:e[0]===i._S?-1:1));for(const[n,o]of m){const n=h*o.plotValue/this.sumPlotValue;o.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,s,c,l){for(const[u,d]of Object.entries(this._freqs))if(u!==i._S){const i=(0,o.zS)(u,l),h=d.bounds,p=h.left;let m=a.S$;c&&(m=c.getMonomerTextColor(s,u)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(p,h.top,h.width,h.height),e.fillStyle=m,e.textAlign="left",e.font=t;const f=e.measureText(i);e.setTransform(h.width/f.width,0,0,h.height/r,p,h.top),e.fillText(i,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,d.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(c||(c={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(l||(l={})),s.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(u||(u={}));const m=new class{render=20};function f(e,t,n,r,o){let s=0,i=-1;for(;-1!=(i=n.findNext(i,!0));){const e=t.getSplitted(i),n=o.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&s++}return s}r.JsViewer},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>T,AR:()=>C});var r=n(7389),o=n(6082),s=n(4328),i=n(1991),a=n.n(i),c=n(1858),l=n(2003),u=n(8070),d=n(7602),h=n(4954),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),w=n(6723);class v extends p.O{seqHelper;emptyProps=new p.n("",void 0,w._package.logger);helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,w._package.logger)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}})).onCancel((()=>{f()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),r.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,h.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class E{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=o}}class C extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class T extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new d.g(this.logger)}static filterCounter=-1;filterId=++T.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new S:this.notation===l.Hi.SEPARATOR?new _(this.column.getTag(l.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(A,new E(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class S extends p.O{emptyProps=new p.n("",void 0,w._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e,void 0,w._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,h.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class _ extends p.O{emptyProps=new C("",void 0,w._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new C(e,this.props.separator,w._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new C(this.props.substructure,t,w._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new C("",void 0,w._package.logger)}get filterPanel(){return r.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,h.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},9713:e=>{"use strict";e.exports=rxjs.operators},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use 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a.data.detectSemanticTypes(o);const s=a.shell.addTableView(o);await S(s.grid),(0,t.E3)(s.grid.dataFrame.id,e.id)})),(0,t.t6)("getHelmMonomers",(async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await a.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],r=t.getCol("HELM"),o=await a.functions.call("Bio:getHelmMonomers",{sequence:r}),s=n.filter((e=>!o.includes(e))),i=o.filter((e=>!n.includes(e)));if(s.length>0||i.length){const e=[];throw s.length>0&&e.push(`Missed monomers ${JSON.stringify(s)}.`),i.length>0&&e.push(`Unexpected monomers ${JSON.stringify(i)}.`),new Error(e.join(" "))}}))}));var N=n(8604);(0,t.L1)("monomerLibraries",(()=>{let e,n=null;(0,t.gM)((async()=>{e=await(0,E.pj)(),n=(0,P.ub)()})),(0,t.Pl)((async()=>{await(0,P.Eu)(n)})),(0,t.t6)("default",(async()=>{await(0,P.Eu)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadMonomerLib(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await e.loadMonomerLibForTests(),function(e,n){const r=n,o=e.getSummaryObj();for(const e in r)r[e]||delete r[e];for(const e in o)o[e]||delete o[e];if(0==Object.keys(r).length&&0!=Object.keys(o).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(r).length&&0==Object.keys(o).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(o,r),(0,t.Xk)(r,o)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(r)} does not match actual ${JSON.stringify(o)}.`)}}(e.getMonomerLib(),N.VV)})),(0,t.t6)("empty",(async()=>{const n=await(0,P.ub)(),r=await e.getFileManager();let o=r.getValidLibraryPaths();0===o.length&&(o=await r.getValidLibraryPathsAsynchronously()),n.exclude=o,n.explicit=[],await(0,P.Eu)(n),await e.loadMonomerLib(!0);const s=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===s.length,!0)})),(0,t.t6)("override",(async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},r=e.getMonomerLib(),o=r.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null===o,!0,`Unexpectedly found monomer '${n.symbol}' `);const s=r.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);s&&(s.lib=void 0),(0,t.Xk)(s,n)}))}));var $=n(7389),L=n(1757),I=n.n(L),R=n(1858),O=n(6873),k=n(5433);async function G(n,r){const o=n(),s=e.DataFrame.fromColumns(o);await a.data.detectSemanticTypes(s);const i=Date.now(),c=(s.columns.byName("MSA"),a.shell.addTableView(s));await S(c.grid),(0,t.E3)(c.grid.dataFrame.id,s.id);const l=Date.now()-i;console.log(`Performance test: ${r}: ${l}ms`)}(0,t.L1)("renderers",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),(0,t.t6)("long sequence performance ",(async()=>{await G(O.dW,"Long sequences")})),(0,t.t6)("many sequence performance",(async()=>{await G(O.fD,"Many sequences")})),(0,t.t6)("rendererMacromoleculeFasta",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),o=r.getCol("Sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:o});s&&(o.semType=s);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await S(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),o=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:o});s&&(o.semType=s);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await S(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=_.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await S(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,_.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),o=(await a.functions.call("Bio:importFasta",{fileContent:r}))[0],s=o.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:s});i&&(s.semType=i);const l=a.shell.addTableView(o);await a.data.detectSemanticTypes(o),console.log("Bio: tests/renderers/afterMsa, table view"),await S(l.grid),(0,t.E3)(l.grid.dataFrame.id,o.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${s.semType}", units="${s.meta.units}", cell.renderer="${s.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(s.meta.units,c.Hi.FASTA),(0,t.E3)(s.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(s.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,y.D)({col:s},n);await S(l.grid),(0,t.E3)(l.grid.dataFrame.id,o.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),o=e.DataFrame.fromCsv(r),s=o.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:s});i&&(s.semType=i);const l=a.shell.addTableView(o);await a.data.detectSemanticTypes(o);const u=await(0,k.r)(s,n,c.Hi.SEPARATOR,"/");await S(l.grid),(0,t.E3)(l.grid.dataFrame.id,o.id);const d=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const r=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),o=a.shell.addTableView(r);await S(o.grid),await r.meta.detectSemanticTypes(),await a.data.detectSemanticTypes(r);const s=r.getCol("sequence"),i=n.getSeqHandler(s).convert(c.Hi.HELM);r.columns.add(i),await S(o.grid),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=_.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const o=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==o)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${o}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const n=e.DataFrame.fromCsv(r);n.currentRowIdx=0;const o=a.shell.addTableView(n);await n.meta.detectSemanticTypes(),await a.data.detectSemanticTypes(n);const s=n.plot.scatter({x:"x",y:"y"});o.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),S(o.grid,500)]);const i=s.root.getBoundingClientRect(),c=s.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:i.left+c.x,clientY:i.top+c.y}),u=I()(s.root).find("canvas").get()[0];await(0,t.PE)(e.debounce((0,R.fromEvent)(u,"mousemove"),200),(()=>{_e.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(I()($.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await S(o.grid,500)}()}),{skipReason:"GROK-17450"});const r="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var D=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,E.pj)(),r=await(0,P.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,P.Eu)(r),await n.loadMonomerLib(!0)}));const o={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:190},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(o))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),o=new D.Jy(null,n,_e.logger,3,(()=>({font:"12px monospace",fontCharWidth:7,separatorWidth:12,monomerToShort:c.zS})));await o.init();const s=r.testList;for(let e=0;e<n.length;++e)o.getCellMonomerLengths(e,1e4);const i=[];for(const[e,t]of v().enumerate(s)){const t={pos:o.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&i.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(i.length>0)throw new Error("Test failed error(s):\n"+i.join(", \n"))}));const s=[10,20,30,40,50,60],i={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(i))(0,t.t6)("hitBounds-"+e,(async()=>{const e=(0,D.Bb)(s,n.x);(0,t.E3)(e,n.tgt)}));const l={mono1:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6/m7/m8/m9\nn1/m2/n3/m4/n5/m6/n7/m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGaps:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGapColumn:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5///n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,180,206,232]}}};for(const[n,r]of Object.entries(l))(0,t.t6)(`getCellMonomerLengths-${n}`,(async()=>{const n=e.DataFrame.fromCsv(r.src.csv);await a.data.detectSemanticTypes(n);const o=n.getCol("seq"),s=new D.Jy(null,o,_e.logger,3,(()=>({fontCharWidth:7,font:"12px monospace",separatorWidth:12,monomerToShort:c.zS})));await s.init();const i=s.getCellMonomerLengths(0,1e3)[1];(0,t.J6)(i,r.tgt.lengths)}))})),(0,t.L1)("converters",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,l.Q)()})),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(r||(r={}));const o={[r.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[r.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[r.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[r.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[r.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[r.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[r.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[r.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[r.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[r.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[r.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[r.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[r.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[r.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[r.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[r.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[r.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[r.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},s=new Set(Object.values(c.gp));async function i(t){const n=o[t],r=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(r),r}function u(e,r){if(e===c.Hi.SEPARATOR&&!r)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(o){const s=n.getSeqHandler(o).convert(e,r);return(0,t.E3)(s.meta.units,e),s}}async function d(e,r,o){const a=(await i(e)).getCol("seq"),l=r(a),u=(await i(o)).getCol("seq");(0,t.J6)(l.toList(),u.toList());const d=n.getSeqHandler(a),h=n.getSeqHandler(l);for(const[e,n]of Object.entries(u.tags)){if(!s.has(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const r=l.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await 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n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function o(e){const o=new H.m(e),s=o.descriptionsArray,i=o.sequencesArray;(0,t.J6)([s,i],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{o(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{o(">description:1\n     MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI  EVF  LFGIVLGLI  PITLAGLFVTAY        LQYRRGDQLDL\n\n>description:3\nM      MELVLKTI      IGPI    VVGVVLR      IVDKWLNKDK\n\n>description:4\nMDR    TDEVSNHTHDKP        TLTWFEEIFEEYHSPFHN\n    ")})),(0,t.t6)("testExtraNewlines",(async()=>{o(">description:1\n\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVF\nLFGIVLGLI\nPITLAGLFVTA\nYLQYRRGDQLDL\n\n>description:3\nM\nME\n\nLVLKTIIG\n\nPIVVGVVLRI\nVDKWLNKDK\n\n\n>description:4\n\nMDRT\n\nDEVSNHTHDKP\n\nTLTWFEEIFEE\n\n\n\nYHSPFHN\n")}))}));var F=n(3890);(0,t.L1)("fastaExport",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,l.Q)()})),function(e){e.single="single",e.multi="multi"}(r||(r={}));const o={[r.single]:{src:"MDYKETLLMPKTDFPMRGGLP",tgt:["MDYKETLLMP","KTDFPMRGGL","P"]},[r.multi]:{src:"M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",tgt:["M[MeI]YKETLL[MeF]P","KTDFPMRGGL","[MeA]"]}};let s;!function(e){e.test1="test1",e.test2="test2"}(s||(s={}));const i={[s.test1]:{srcCsv:"id,seq\n1,MDYKETLLMP\n2,KTDFPMRGGL\n3,P",idCols:["id"],seqCol:"seq",lineWidth:10,tgtFasta:">1\nMDYKETLLMP\n>2\nKTDFPMRGGL\n>3\nP\n"},[s.test2]:{srcCsv:"id,id2,seq\n1,seqA,M[MeI]YKETLL[MeF]P\n2,seqB,KTDFPMRGGL\n3,seqC,[MeA]\n",idCols:["id2","id"],seqCol:"seq",lineWidth:5,tgtFasta:">seqA|1\nM[MeI]YKE\nTLL[MeF]P\n>seqB|2\nKTDFP\nMRGGL\n>seqC|3\n[MeA]\n"}};function a(r,s=10){const i=o[r].src,a=e.Column.fromStrings("src",[i]);a.semType=e.SEMTYPE.MACROMOLECULE,a.meta.units=c.Hi.FASTA;const l=n.getSeqHandler(a).getSplitted(0),u=(0,F.aS)(l,s),d=o[r].tgt;(0,t.J6)(u,d)}async function u(r){const o=e.DataFrame.fromCsv(r.srcCsv),s=o.getCol(r.seqCol);s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA;const 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o=r.getCol("seq"),s=n.getSeqHandler(o),i=o.version,c=n.getSeqHandler(o),l=o.version;(0,t.E3)(i,l,"Unexpected column version changed"),(0,t.E3)(s,c,"Unexpected SeqHandler object changed"),r.rows.addNew(["TACCCCTTCAAC"]);const u=n.getSeqHandler(o),d=o.version;(0,t.E3)(l<d,!0,"Stalled column version on add row"),(0,t.E3)(c!==u,!0,"Stalled SeqHandler object on add row"),o.set(1,"CAGTGTCCCCGT");const h=n.getSeqHandler(o),p=o.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(u!==h,!0,"Stalled SeqHandler object on change data"),o.setTag("testTag","testValue");const m=n.getSeqHandler(o),f=o.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),(oe=re||(re={})).fasta="fasta",oe.fastaMsa="fastaMsa",oe.separator="separator",oe.separatorMsa="separatorMsa",oe.helm="helm",(0,t.L1)("SeqHandler: splitted",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),U.b9[c.Hi.FASTA],U.b9[c.Hi.HELM];const r=U.b9[c.Hi.SEPARATOR],o={[re.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[re.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[re.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[re.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",r,"abc1","dfgg","rut12","her2","rty",r,"abc1","dfgg"],["rut2","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],["rut3","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],[r,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",r]]}},[re.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$,\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK}|PEPTIDE2{Thr_PO3H2}$$$$"},tgt:{notation:c.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[r,s]of Object.entries(o))(0,t.t6)(`${r}`,(async()=>{const r=e.DataFrame.fromCsv(s.src.csv).getCol("seq"),o=await a.functions.call("Bio:detectMacromolecule",{col:r});o&&(r.semType=o),(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const i=n.getSeqHandler(r);(0,t.E3)(i.notation,s.tgt.notation),(0,t.E3)(i.separator===s.tgt.separator,!0);const c=v().count(0).take(i.length).map((e=>{const t=i.getSplitted(e);return v().count(0).take(t.length).map((e=>t.getOriginal(e))).toArray()})).toArray();(0,t.J6)(c,s.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:c.Hi.FASTA,alphabet:c.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:c.Hi.SEPARATOR,alphabet:c.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 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i=n.getSeqHandler(r).getRegion(s.startIdx,s.endIdx,"regSeq"),l=e.DataFrame.fromCsv(s.tgtCsv).getCol("seq");(0,t.E3)(r.meta.units,s.units),(0,t.E3)(i.meta.units,s.units),(0,t.E3)(r.getTag(c.gp.alphabet),s.alphabet),(0,t.E3)(i.getTag(c.gp.alphabet),s.alphabet),(0,t.J6)(i.toList(),l.toList())})),s.positionNames&&(0,t.t6)(`${o}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(s.srcCsv).getCol("seq");s.positionNames.tag&&n.setTag(c.gp.positionNames,s.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const o=await a.functions.call("Bio:getRegion",{sequence:n,start:s.positionNames.start,end:s.positionNames.end}),i=e.DataFrame.fromCsv(s.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,s.units),(0,t.E3)(o.meta.units,s.units),(0,t.E3)(n.getTag(c.gp.alphabet),s.alphabet),(0,t.E3)(o.getTag(c.gp.alphabet),s.alphabet),(0,t.J6)(o.toList(),i.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r,o;(0,t.gM)((async()=>{n=await(0,l.Q)(),r=await(0,E.pj)(),o=await(0,P.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,P.Eu)(o),await r.loadMonomerLib(!0)}));const s={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(s))(0,t.t6)(e,(async()=>{await i(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function i(r,o,s,i){const c=e.Column.fromStrings("seq",[r]),l=e.DataFrame.fromColumns([c]);await a.data.detectSemanticTypes(l);const u=n.getSeqHandler(c),d=(await u.getValue(0)).helm;(0,t.E3)(d,i)}}));var se=n(6956);class ie{constructor(e){const t=e.split(se.xe).filter((e=>e));t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],r=t.split(",");r[2].split("-").forEach(((e,t)=>{const o=r[t],s=e.split(":"),i={monomerIdx:parseInt(s[0])-1,rGroupId:parseInt(s[1].slice(1))};n.push({polymerId:o,bond:i})})),e.push(n)})),e}}var ae=n(8438);class ce{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],r=[];return t.forEach((e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter((e=>!!e)).map((e=>(0,ae.D)(e)));n.push(...t),t.forEach(((e,t)=>r.push(t%3==1?"Branch":"Backbone")))}else n.push((0,ae.D)(e)),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const r=t[n],o=t[n+1];e.push([{monomerIdx:r,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const r=n[t],o=r-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:r,rGroupId:1}])}return e}}class le{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(se.pk),n=t[0].split(se.xe);this.simplePolymers=n.map((e=>new ce(e))),this.connectionList=new ie(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map((e=>e.monomers.length)).reduce(((e,t)=>e+t),0),t=Array.from({length:e},(()=>[]));return this.bondData.forEach((e=>{e.forEach((e=>{const n=e.monomerIdx,r=e.rGroupId;t[n].push(r)}))})),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const r=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===r))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const 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e={"single-linear":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T.[meI]}$$$$"},tgt:{simplePolymers:[6],connections:[],bondedRGroups:[1,2,2,2,2,1]}},"single-cyclized-C-2-2":{src:{helm:"PEPTIDE1{R.F.C.Y.G.H.[GGaz].C.T.[meI]}$PEPTIDE1,PEPTIDE1,3:R3-8:R3$$$"},tgt:{simplePolymers:[10],connections:[[["PEPTIDE1",3,"R3"],["PEPTIDE1",8,"R3"]]],bondedRGroups:[1,2,3,2,2,2,2,3,2,1]}},"single-cyclized-C-1-1":{src:{helm:"PEPTIDE1{F.C.Y.G.H.[GGaz].C.[meI]}$PEPTIDE1,PEPTIDE1,2:R3-7:R3$$$"},tgt:{simplePolymers:[8],connections:[[["PEPTIDE1",2,"R3"],["PEPTIDE1",7,"R3"]]],bondedRGroups:[1,3,2,2,2,1,3,1]}},"single-cyclized-C-0-0":{src:{helm:"PEPTIDE1{C.Y.G.H.[GGaz].C}$PEPTIDE1,PEPTIDE1,1:R3-6:R3$$$"},tgt:{simplePolymers:[6],connections:[[["PEPTIDE1",1,"R3"],["PEPTIDE1",6,"R3"]]],bondedRGroups:[2,2,2,2,2,2]}},"two-separated-5-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$$$$"},tgt:{simplePolymers:[5,1],connections:[],bondedRGroups:[1,2,2,2,1,0]}},"two-separated-1-5":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.Y.[GGaz].T}$$$$"},tgt:{simplePolymers:[1,5],connections:[],bondedRGroups:[0,1,2,2,2,1]}},"two-separated-4-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$$$$"},tgt:{simplePolymers:[4,2],connections:[],bondedRGroups:[1,2,2,1,1,1]}},"two-connected-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$PEPTIDE1,PEPTIDE2,5:R2-1:R1$$$"},tgt:{simplePolymers:[5,1],connections:[[["PEPTIDE1",5,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-connected-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$PEPTIDE1,PEPTIDE2,4:R2-1:R1$$$"},tgt:{simplePolymers:[4,2],connections:[[["PEPTIDE1",4,"R2"],["PEPTIDE2",1,"R1"]]],bondedRGroups:[1,2,2,2,2,1]}},"two-cyclized-1-9":{src:{helm:"PEPTIDE1{[meI]}|PEPTIDE2{R.F.[GGaz].T.G.H.F.Y.P}$PEPTIDE2,PEPTIDE2,3:R3-9:R2|PEPTIDE2,PEPTIDE1,3:R4-1:R1$$$V2.0"},tgt:{simplePolymers:[1,9],connections:[[["PEPTIDE2",3,"R3"],["PEPTIDE2",9,"R2"]],[["PEPTIDE2",3,"R4"],["PEPTIDE1",1,"R1"]]],bondedRGroups:[1,1,2,4,2,2,2,2,2,1]}}};for(const[n,{src:r,tgt:o}]of Object.entries(e))(0,t.t6)(n,(async()=>{const e=new le(r.helm),n=e.simplePolymers.map((e=>e.monomers.length)),s=n.reduce(((e,t)=>e+t),0);(0,t.J6)(n,o.simplePolymers);const i=e.connectionList.getConnectionData().map((e=>[[e[0].polymerId,e[0].bond.monomerIdx+1,`R${e[0].bond.rGroupId}`],[e[1].polymerId,e[1].bond.monomerIdx+1,`R${e[1].bond.rGroupId}`]]));(0,t.J6)(i,o.connections);const a=v().count(0).take(e.bondedRGroupsMap.length).map((t=>e.bondedRGroupsMap[t].length)).toArray();(0,t.E3)(s,a.length)}))}));var ue=n(6077),de=n(6717);const he=new 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0!==o.undirected&&(a=l(e,o.undirected,s,r),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,o){for(var s in i){var r=i[s],a=r.source,l=r.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=o(c.key,c.attributes);if(e&&u)return c.key}}}function pe(e,t,n,i,o){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,o);if("string"==typeof n)return de(e,null,i,i[n],o)}var s,r=new he;if("undirected"!==t){if("out"!==n){if(s=de(e,null,i,i.in,o),e&&s)return s;r.wrap(i.in)}if("in"!==n){if(s=de(e,r,i,i.out,o),e&&s)return s;r.wrap(i.out)}}if("directed"!==t&&(s=de(e,r,i,i.undirected,o),e&&s))return s}function me(e,t,n){var i=Object.keys(n),o=i.length,s=0;return new P((function(){var r=null;do{if(s>=o)return e&&e.wrap(n),{done:!0};var a=n[i[s++]],l=a.source,c=a.target;r=l===t?c:l,e&&e.has(r.key)&&(r=null)}while(null===r);return{done:!1,value:{neighbor:r.key,attributes:r.attributes}}}))}function ge(e,t,n,i,o){for(var s,r,a,l,c,u,h,d=i._nodes.values(),p=i.type;!0!==(s=d.next()).done;){var m=!1;if(r=s.value,"undirected"!==p)for(a in l=r.out){c=l[a];do{if(u=c.target,m=!0,h=o(r.key,u.key,r.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=r.undirected)if(!(t&&r.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),m=!0,h=o(r.key,u.key,r.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!m&&(h=o(r.key,null,r.attributes,null,null,null,null),e&&h))return null}}function fe(e){if(!c(e))throw new B('Graph.import: invalid serialized node. 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Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ce={allowSelfLoops:!0,multi:!1,type:"mixed"};function Te(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function Se(e,t,n,i,o,s,r,a){if(!i&&"undirected"===e.type)throw new U("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new U("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,r=""+r,a=a||{},!e.allowSelfLoops&&s===r)throw new U("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(s),u=e._nodes.get(r);if(!l)throw new V("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(r,'" not found.'));var h={key:null,undirected:i,source:s,target:r,attributes:a};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[r]:void 0!==l.out[r]))throw new U("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(r,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new j(i,o,l,u,a);e._edges.set(o,d);var p=s===r;return i?(l.undirectedDegree++,u.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=o,e.emit("edgeAdded",h),o}function Ee(e,t,n,i,o,s,r,l,u){if(!i&&"undirected"===e.type)throw new U("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new U("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new B("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new B("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(s=""+s,r=""+r,u&&(h=l,l=void 0),!e.allowSelfLoops&&s===r)throw new U("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(s),g=e._nodes.get(r);if(!n&&(d=e._edges.get(o))){if(!(d.source.key===s&&d.target.key===r||i&&d.source.key===r&&d.target.key===s))throw new U("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(s,'" source & "').concat(r,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[r]:m.out[r]),p){var f=[p.key,!1,!1,!1];if(u?!h:!l)return f;if(u){var y=p.attributes;p.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return f}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:s,target:r,attributes:l};if(n)o=e._edgeKeyGenerator();else if(o=""+o,e._edges.has(o))throw new U("Graph.".concat(t,': the "').concat(o,'" edge already exists in the graph.'));var w=!1,v=!1;m||(m=Te(e,s,{}),w=!0,s===r&&(g=m,v=!0)),g||(g=Te(e,r,{}),v=!0),d=new j(i,o,m,g,l),e._edges.set(o,d);var A=s===r;return i?(m.undirectedDegree++,g.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,g.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=o,e.emit("edgeAdded",b),[o,!0,w,v]}function Me(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,o=t.attributes,s=t.undirected,r=n===i;s?(n.undirectedDegree--,i.undirectedDegree--,r&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,r&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:o,source:n.key,target:i.key,undirected:s})}var xe=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ce,e)).multi)throw new B("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new B('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new B("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?W:"directed"===e.type?q:Y;h(r(t),"NodeDataClass",i);var o="geid_"+we()+"_",s=0;return h(r(t),"_attributes",{}),h(r(t),"_nodes",new Map),h(r(t),"_edges",new Map),h(r(t),"_directedSize",0),h(r(t),"_undirectedSize",0),h(r(t),"_directedSelfLoopCount",0),h(r(t),"_undirectedSelfLoopCount",0),h(r(t),"_edgeKeyGenerator",(function(){var e;do{e=o+s++}while(t._edges.has(e));return e})),h(r(t),"_options",e),Ae.forEach((function(e){return h(r(t),e,t[e])})),d(r(t),"order",(function(){return t._nodes.size})),d(r(t),"size",(function(){return t._edges.size})),d(r(t),"directedSize",(function(){return t._directedSize})),d(r(t),"undirectedSize",(function(){return t._undirectedSize})),d(r(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(r(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(r(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(r(t),"multi",t._options.multi),d(r(t),"type",t._options.type),d(r(t),"allowSelfLoops",t._options.allowSelfLoops),d(r(t),"implementation",(function(){return"graphology"})),t}t(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(e){return this._nodes.has(""+e)},o.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.out.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);return!!o&&o.undirected.hasOwnProperty(t)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new B("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new U("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},o.edge=function(e,t){if(this.multi)throw new U("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},o.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},o.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},o.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},o.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},o.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},o.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},o.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},o.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},o.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},o.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},o.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},o.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},o.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},o.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},o.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},o.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},o.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},o.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},o.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},o.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},o.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(e===i)return o;if(e===o)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},o.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},o.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},o.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},o.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new B('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new U('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},o.mergeNode=function(e,t){if(t&&!c(t))throw new B('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},o.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new B('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var o=t?t({}):{};return n=new this.NodeDataClass(e,o),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:o}),[e,!0]},o.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{Me(this,t),t=t.next}while(t)}for(var o in n.in){t=n.in[o];do{Me(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{Me(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},o.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return Me(this,t),this},o.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new U("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new U("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return Me(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(e){return this._attributes[e]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},o.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.updateAttribute=function(e,t){if("function"!=typeof t)throw new B("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},o.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},o.replaceAttributes=function(e){if(!c(e))throw new B("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(e){if(!c(e))throw new B("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},o.updateAttributes=function(e){if("function"!=typeof e)throw new B("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new B("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},o.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new B("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new B("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,s,r=this._edges.values();!0!==(n=r.next()).done;)o=(i=n.value).source,s=i.target,i.attributes=e(i.key,i.attributes,o.key,s.key,o.attributes,s.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},o.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntry: expecting a callback.");ge(!1,!1,!1,this,e)},o.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!1,!0,this,e)},o.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ge(!1,!0,!1,this,e)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new B("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ge(!1,!0,!0,this,e)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):D(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(e){if("function"!=typeof e)throw new B("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},o.findNode=function(e){if("function"!=typeof e)throw new B("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},o.mapNodes=function(e){if("function"!=typeof e)throw new B("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),o=new Array(this.order),s=0;!0!==(t=i.next()).done;)n=t.value,o[s++]=e(n.key,n.attributes);return o},o.someNode=function(e){if("function"!=typeof e)throw new B("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},o.everyNode=function(e){if("function"!=typeof e)throw new B("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},o.filterNodes=function(e){if("function"!=typeof e)throw new B("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),o=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(e,t){if("function"!=typeof e)throw new B("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new B("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=t,s=this._nodes.values();!0!==(n=s.next()).done;)o=e(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var e=this._nodes.values();return new P((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,o){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,o,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},o.import=function(e){var t,n,o,s,r,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,o,s,r){l?r?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):r?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new B("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new B("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(o=e.nodes,!Array.isArray(o))throw new B("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=o.length;t<n;t++){fe(s=o[t]);var u=s,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=e.edges,!Array.isArray(o))throw new B("Graph.import: invalid edges. 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){s.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){s.shell.error("Error applying input from history"),console.error(e)}}}var H=n(9713),k=n(6295);const F=e=>null==e;function D(e,t,n,i){if(n>e[e.length-1])return;const o=e.findIndex((e=>n<e));e.pop(),e.splice(o,0,n),t.pop(),t.splice(o,0,i)}class G{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,o){return await this.calcMulti([e],[t],n,[o??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,o=[{}],s=[1],r=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||o.length!==e.length||s.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,p=1,m=0,g=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),f=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*f+4*a*(a-1)-7)/2-.5),p=f-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:f-i,opts:o,weights:s,aggregationMethod:r}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:s,min:r,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),o?t(o):(h.set(s,i),r<m&&(m=r),a>g&&(g=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-m)/(g-m)})),i(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),o=e.distance.length,s=e.distance;for(let e=0;e<o;e++)i[Math.floor(s[e]*n)]++;let r=0,a=0;for(let e=0;e<n&&(r+=i[e],a=e,!(r>=t));e++);const l=new Uint32Array(r),c=new Uint32Array(r),u=new Float32Array(r),h=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<o;e++)s[e]<m&&(l[p]=h[e],c[p]=d[e],u[p]=s[e],p++);return{i:l,j:c,distance:u}}async calcMultiColumn(e,t,o,s=[{}],r=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,s,r,a):0;o<u&&(console.log(`using threshold ${u}`),o=u),s.forEach(((e,t)=>s[t].threshold=o));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,u)=>{const h=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:p,threshold:o,fnNames:t,opts:s,weights:r,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:o,distance:s}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:o,distance:s,idx:n}))}}));const p=await Promise.all(h),m=p.reduce(((e,t)=>e+t.i.length),0),g=new Int32Array(m),f=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)g.set(e.i,b),f.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:g,j:f,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,o=.8,s,r,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==r.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:s,threshold:o,weights:r,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}}));const d=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,o,s=15,r,a,l=i.EUCLIDEAN){if(e.length!==o.length||e.length!==r.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),u=new Array(this._workerCount),h=e[0].length,d=e.map((e=>e[t])),p=Math.ceil(h/this._workerCount);for(let t=0;t<this._workerCount;t++)u[t]=new Promise(((n,i)=>{const u=t*p,m=t===this._workerCount-1?h:(t+1)*p;m<=u&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map((e=>e.slice(u,m))),target:d,fnNames:o,opts:r,nNeighbours:s,weights:a,aggregationMethod:l,startIdx:u}),c[t].onmessage=({data:{error:e,knnDistances:o,knnIndexes:s}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:o,knnIndexes:s}))}}));const m=await Promise.all(u),g={knnDistances:new Array(s).fill(99999),knnIndexes:new Array(s).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)D(g.knnDistances,g.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return g}async multiColumnKNN(e,t,o=15,s,r,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==r.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:s,nNeighbours:o,weights:r,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:o}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:o}))}}));const d=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(o).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(o).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)D(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,o=[],s,r=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:u,fnNames:t,opts:o,weights:s,aggregationMethod:r}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let g=0;for(const e of d)m.set(e.distance,g),g+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],o,s=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,r=await this.getSampleDistances(e,t,n,o,s);return 1-r[Math.floor(7e7/i*r.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const o=[],s=[],r=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=F(e[l])||F(e[c])?1:n(e[l],e[c]);1-t>=i&&(o.push(l),s.push(c),r.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(s),distance:new Float32Array(r)}}}var V,U,W=n(8774);(U=V||(V={})).none="none",U.bold="bold",U.dashed="dashed";class q{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,o=V.none){var s;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(s=i.visibility)&&void 0!==s?s:new W.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,o,s,r,a,l,c,u,h,d,p,m,g,f;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,w=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let v=null==b?void 0:b.x,A=null==b?void 0:b.y;const C=this.sp.pointToScreen(this.lines.to[e]);let T=null==C?void 0:C.x,S=null==C?void 0:C.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),v&&A&&T&&S&&Math.hypot(T-v,S-A)/E>.01){if(y){const t=(null===(o=this.lines.colors)||void 0===o?void 0:o[e])?null===(s=this.lines.colors)||void 0===s?void 0:s[e]:null!==(r=this.lines.color)&&void 0!==r?r:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let C=null;if(b){t=this.getLineLength(v,A,T,S);const o=this.getPointOnDistance(v,A,T,S,i,t),s=this.getPointOnDistance(T,S,v,A,n,t);v=o.x,A=o.y,T=s.x,S=s.y,C=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,v,A,T,S,e):this.findControlPoint(b,T,S,v,A,e),this.ctx.moveTo(v,A),this.ctx.quadraticCurveTo(C.x,C.y,T,S)}else(!this.lines.skipShortLines||Math.pow(T-v,2)+Math.pow(S-A,2)>w)&&(this.ctx.moveTo(v,A),this.ctx.lineTo(T,S));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(v,A,T,S)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(v,A,T,S,i,t),n=b?C.x:v,o=b?C.y:A;this.canvasArrow(this.ctx,null!==(g=null==e?void 0:e.x)&&void 0!==g?g:v,null!==(f=null==e?void 0:e.y)&&void 0!==f?f:A,n,o)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,o=null;const s=this.sp.dataFrame.filter;for(let r=0;r<this.lines.from.length;r++)if(s.get(this.lines.from[r])&&s.get(this.lines.to[r])&&this.visibility.getBit(r)){const s=this.sp.getMarkerSize(this.lines.from[r])/2,a=this.sp.getMarkerSize(this.lines.to[r])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[r]),this.yAxisCol.get(this.lines.from[r])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[r]),this.yAxisCol.get(this.lines.to[r]));if(this.multipleLinesCounts[r]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,s,n),h=this.lines.from[r]>this.lines.to[r]?this.findControlPoint(this.multipleLinesCounts[r],i.x,i.y,u.x,u.y,r):this.findControlPoint(this.multipleLinesCounts[r],u.x,u.y,i.x,i.y,r);o=this.calculateDistToCurveLine(r,e,t,i,u,h)}else o=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=r)}return n}calculateDistToStraightLine(e,t,n,i){const o=Math.min(n.x,i.x),s=Math.max(n.x,i.x),r=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=o-2&&e<=s+2&&t>=r-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const o=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),s=o(n.x,n.y,i.x,i.y);if(0==s)return o(e,t,n.x,n.y);let r=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/s;return r=Math.max(0,Math.min(1,r)),o(e,t,n.x+r*(i.x-n.x),n.y+r*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,o,s){const r=Math.min(i.x,o.x,s.x),a=Math.max(i.x,o.x,s.x),l=Math.min(i.y,o.y,s.y),c=Math.max(i.y,o.y,s.y);if(t>=r-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-r,u=c-l;return this.calculateDistToCurveInRect(t,n,i,s,o,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,o,s,r){const a=Math.floor((s+r)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const p=new W.A(a);for(let s=0;s<c.length;s++){const r=s*l,a=Math.pow(1-r,2)*n.x+2*r*(1-r)*i.x+Math.pow(r,2)*o.x,p=Math.pow(1-r,2)*n.y+2*r*(1-r)*i.y+Math.pow(r,2)*o.y,m=Math.abs(e-a),g=Math.abs(t-p),f=m+g;(!d||d>f)&&(d=f),h[s]=Math.max(m,g),c[s]=a,u[s]=p}for(let e=0;e<c.length;e++)h[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,o,s){const r=n-o*((n-e)/s),l=i-o*((i-t)/s);return new a.Point(r,l)}findControlPoint(e,t,n,i,o,s){const r=t+(i-t)/2,l=n+(o-n)/2;let c=r-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(r+d/2*u,l-d/2*c):new a.Point(r-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,o){const s=Math.atan2(i-t,o-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(s-Math.PI/10),n-this.arrowWidth*Math.cos(s-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(s+Math.PI/10),n-this.arrowWidth*Math.cos(s+Math.PI/10))}}const Y="dimensionality-reducer-terminate-event";var j,K,z=n(3629);async function Z(e,t,i,o,r,a,l){let c=await async function(e,t,i,o,r,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:o,aggregationMethod:r});const d=s.events.onCustomEvent(Y).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{F(n)||F(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,o,r,a,l);return c=c.map((e=>(0,z.S8)(e))),c}(K=j||(j={})).EUCLIDEAN="EUCLIDEAN",K.MANHATTAN="MANHATTAN";const X={[j.EUCLIDEAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[j.MANHATTAN]:function(e){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${e}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const ee={[J.HAMMING]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.EUCLIDEAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(e,t){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(e,t){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(e,t){return`\n      let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${e+1}u>;\n      var horizontalGaps: array<u32, ${e+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${e}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${e};\n  `},[J.SOKAL]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(e,t){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${e}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(e,t){return`\n    let range = suppInfo.range${t};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(e,t){return`\n  let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},te={[J.HAMMING]:e=>Math.ceil(e/30),[J.EUCLIDEAN]:e=>Math.ceil(e/30),[J.MANHATTAN]:e=>Math.ceil(e/30),[J.TANIMOTO]:e=>Math.ceil(e/30),[J.SOKAL]:e=>Math.ceil(e/30),[J.COSINE]:e=>Math.ceil(e/30),[J.ASYMMETRIC]:e=>Math.ceil(e/30),[J.LEVENSTEIN]:e=>Math.ceil(e*e/60),[J.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[J.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[J.Difference]:e=>1,[J.OneHot]:e=>Math.ceil(e/40),[J.VECTOR_COSINE]:e=>Math.ceil(e/30)},ne={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};function ie(e,t=.8,n,i,o,s){return function(e,t,n,i){return new(n||(n=Promise))((function(o,s){function r(e){try{l(i.next(e))}catch(e){s(e)}}function a(e){try{l(i.throw(e))}catch(e){s(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(r,a)}l((i=i.apply(e,t||[])).next())}))}(this,void 0,void 0,(function*(){const r=yield function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==M))return null;let e=!1;if(x&&(x.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!x||e){const e=1e9,t=M.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return x=yield M.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),x}catch(e){return console.error("Failed to create device with required limits",e),x=yield M.requestDevice(),x}}return x}))}();if(!r)return null;const a=Object.values(J);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(j).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(s.length!==e.length||s.length!==n.length||s.length!==o.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=J.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var o,s;let r=null;const a=e.some((e=>"string"==typeof e))?(r="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(r="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(r="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(r="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(r="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(r="INT32ARRAY",e):void 0;if(!a||!r)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!ne[r]||!ne[r].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${r}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=te[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",g=0,f="FLOAT32ARRAY",y=null;if(t===J.NEEDLEMAN_WUNSCH||t===J.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),r=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)r[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(r[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);g=2+t,f="FLOAT32ARRAY",y=new Float32Array(g),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(s=i.gapExtensionPenalty)&&void 0!==s?s:.6;let l=2;for(let e=0;e<r.length;e++)y.set(r[e],l),l+=r[e].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);i.range=t-e}i.range<=0&&(i.range=1),g=1,f="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",w=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:g,suppInfoType:f,suppInfoStructWgsl:m,entryType:r,dataTypeWGSL:b,dataStructWgsl:w,EncodedArrayConstructor:d}}(e,n[t],t,s[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=j.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),g=new Uint32Array(c*u);h.forEach(((e,t)=>{g.set(e.arraySizes,t*u)}));const f=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),w=Math.ceil(6e3/b),v=Math.ceil(Math.sqrt(Math.ceil(100))),A=10*v,C=u*(u-1)/2,T=Math.ceil(C/f),S=r.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${T} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${u}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${A} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${w}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${u}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${oe(n,h.map((e=>e.maxEntryLen)),l,i)}\n\n\n    `}),L=r.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:S,entryPoint:"calcSparseMatrix"}}),_=new Uint32Array(f),I=new Uint32Array(f),P=new Uint32Array(f),N=new Uint32Array(f),R=Math.floor(C/f);let $=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<f;e++){const t=9999===e?C-1:(e+1)*R,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);_[e]=O,I[e]=$,P[e]=i,N[e]=n,$=n,O=i}console.timeEnd("GPUthreadStarts");const H=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),k=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,D=H*Uint32Array.BYTES_PER_ELEMENT;let G=D;const B=15&D;0!==B&&(G+=16-B);const V=r.createBuffer({label:"compute info buffer",size:G,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),U=V.getMappedRange();let W=0;new Uint32Array(U,W,f).set(_),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(U,W,f).set(I),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(U,W,f).set(P),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(U,W,f).set(N),W+=f*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(U,W,g.length).set(g),W+=g.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(U,W,c).set(o),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(U,W,n).set(e.flatSourceArray),W+=n*t.BYTES_PER_ELEMENT}V.unmap();const q=k*Uint32Array.BYTES_PER_ELEMENT;let Y=q;const K=15&q;0!==K&&(Y+=16-K),Y=Math.max(Y,16);const z=r.createBuffer({label:"supp info buffer",size:Y,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),Z=z.getMappedRange();let X=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(Z,X,e.suppInfoBuffer.length).set(e.suppInfoBuffer),X+=e.suppInfoBuffer.byteLength);0===X&&new Uint32Array(Z,0,4).set([1,1,1,1]),z.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ee=Q;const ie=15&Q;0!==ie&&(ee+=16-ie);const se=r.createBuffer({label:"results buffer",size:ee,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),re=r.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:L.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:z}},{binding:2,resource:{buffer:se}}]}),ae=r.createBuffer({label:"results out buffer",size:se.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=r.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(L),t.setBindGroup(0,re),t.dispatchWorkgroups(v,v),t.end(),e.copyBufferToBuffer(se,0,ae,0,ae.size);const n=e.finish();r.queue.submit([n]),yield r.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let o=0;const s=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,F);o+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,F);o+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,f);o+=f*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,o,f).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(s.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(h),ce.push(d),ue.push(p),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(de),me=new Uint32Array(de),ge=new Float32Array(de);let fe=0;for(let e=0;e<le.length;e++)pe.set(le[e],fe),me.set(ce[e],fe),ge.set(ue[e],fe),fe+=le[e].length;return V.destroy(),z.destroy(),se.destroy(),ae.destroy(),{i:pe,j:me,distance:ge}}))}function oe(e,t,n,i){return e.map(((e,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${ee[e](t[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${e.length}>;\n        ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n        ${X[i](e.length)}\n      }\n    \n    `}let se=0;const re="cliffsDf",ae=new u.Subject,le="SALI",ce="line index",ue=["From","To"],he="filterCliffs";async function de(e,t,i,o,l,c,u,h,d,p,m,g,f,y,b,w,v){se++;const A=c/100;let C,T=!1;const S=g.inputs,E=await g.apply({[S[0].name]:t,[S[1].name]:u,...d.preprocessingFuncArgs??{}});let M=[];if(h===P){const t=await function(e,t,i,o,s,r,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:o,distanceFns:s,distanceFnArgs:r,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([E.entries],c,[1],"MANHATTAN",[u],[E.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),M=[t.embedX,t.embedY]}else M=await Z([E.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[E.options??{}]});if(M.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<M.length;++t)e.columns.addNewFloat(i[t]).init((e=>M[t][e]));let x=null;if(d.useWebGPU)try{x=await ie([E.entries],A,[u],j.MANHATTAN,[1],[E.options??{}])}catch(e){console.error(e)}x||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),x=await(new B).calc(E.entries,u,A,E.options));const L=await async function(e,t){const n=e.distance.map(((n,i)=>{const o=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?o/n:1/0})),i=e.distance.map((e=>1-e)),o=e.i,s=e.j,r=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{r.set(e.i[n],!0),r.set(e.j[n],!0)})),{simVals:i,saliVals:n,n1:o,n2:s,cliffsBitSet:r}}(x,l),_=function(e,t,n,i,o,s,r){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(r.get(i[e])>r.get(o[e])?l[i[e]]+=n[e]:l[o[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,L.saliVals,L.n1,L.n2,0,l);e.columns.add(_);const I=L.cliffsBitSet,N=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}(L.saliVals),$=.8/(N.max-N.min),O=s.shell.getTableView(e.name),k=O.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:_.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),F=function(e,t,n,i,o,s,r,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-r.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return ue.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),s),u.col(e).semType=o})),u.columns.addNewFloat("Δ activity").init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),u.columns.addNewInt(ce).init((e=>e)),u.columns.addNewFloat(le).init((e=>t.saliVals[e])),u.columns.addNewFloat("Similarity").init((e=>t.simVals[e])),u.name=`${re}${se}`,{lines:c,linesDf:u}}(e,L,t,l,p,m,N,$);F.lines.skipMultiLineCalculation=!0,F.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const D=new q(k,i[0],i[1],F.lines,V.none),G=b?b(F.linesDf,ue).sort([le],[!1]):F.linesDf.plot.grid().sort([le],[!1]);G.col(ce)&&(G.col(ce).visible=!1),e.temp[".cliffsDfGrid"]=G;const U=r.button(`${F.linesDf.rowCount} cliffs`,(()=>{const e=R()(O.viewers).some((e=>e.dataFrame.name===`${re}${se}`));v&&!e&&O.addViewer(G),O.dockManager.dock(G,"down",null,"Activity cliffs",w??.2)}));U.classList.add("scatter_plot_link","cliffs_grid");const W=r.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(k.dataFrame.setTag(he,i[0]),e.filter.and(I),ae.next(i[0])):(k.dataFrame.setTag(he,""),e.filter.setAll(!0),ae.next(""))}});k.root.prepend(r.divH([U,W.root],"cliffs_div")),ae.subscribe((e=>{W.enabled=""===e||e===i[0]})),e.onRowsFiltering.subscribe((()=>{W.value&&e.filter.and(L.cliffsBitSet)}));const Y=s.events.onViewerClosed.subscribe((e=>{e.args.viewer===k&&(O.dockManager.close(G.root),Y.unsubscribe(),O.subs=O.subs.filter((e=>e!==Y)))}));return O.subs.push(Y),F.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<F.linesDf.rowCount;e++)F.lines.widths[e]=e===F.linesDf.currentRowIdx?3:1;D.linesToRender=F.lines;const n=F.linesDf.currentCol&&F.linesDf.currentCol.name===ue[1]?F.lines.to:F.lines.from,o=-1!==F.linesDf.currentRowIdx?F.linesDf.currentRowIdx:null;if(k.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=F.linesDf.currentRowIdx;D.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,o,s){const r=Math.abs(n-o),a=Math.abs(i-s),l=e/r,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,p=(n<o?n:o)+r/2-h/2,m=(i>s?i:s)-a/2+d/2;return{zoomLeft:p,zoomRight:p+h,zoomTop:m,zoomBottom:m-d}}(k.viewport.width,k.viewport.height,k.dataFrame.get(i[0],F.lines.from[n]),k.dataFrame.get(i[1],F.lines.from[n]),k.dataFrame.get(i[0],F.lines.to[n]),k.dataFrame.get(i[1],F.lines.to[n]));k.zoom(a,u,c,h),W.value?e.filter.and(I):!0===W.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,o,a,l,c,u){const h=t.getPane("Cliff Details");r.empty(h.root);const d=u({points:[n,i],lineId:o,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{s.shell.o=t.root}),500)}(e,C,F.lines.from[o],F.lines.to[o],o,t,l,F.linesDf.get(le,o),y);const n=k.dataFrame.getSortedOrder(O.grid.sortByColumns,O.grid.sortTypes);O.grid.scrollToCell(t.name,n.indexOf(k.dataFrame.currentRowIdx))}),1e3)}})),F.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<F.linesDf.rowCount;e++){const n=F.linesDf.selection.get(e);n&&(t.set(F.lines.from[e],!0),t.set(F.lines.to[e],!0)),F.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),D.linesToRender=F.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(T?T=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<F.lines.colors.length;e++)F.lines.colors[e]="0,128,0";D.linesToRender=F.lines})(G.dataFrame))})),D.lineClicked.subscribe((t=>{if(T=!0,D.currentLineId=t.id,-1!==t.id){const n=F.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),F.linesDf.selection.copyFrom(n)):(F.linesDf.currentRowIdx!==t.id&&(F.linesDf.currentRowIdx=t.id,e.currentRowIdx=F.lines.from[t.id]),F.linesDf.selection.copyFrom(n));const i=F.linesDf.getSortedOrder(G.sortByColumns,G.sortTypes);G.scrollToCell(ue[0],i.indexOf(t.id))}),500)}})),D.lineHover.pipe((0,H.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&r.tooltip.show(f({lineId:n.id,points:[F.lines.from[n.id],F.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),k.addProperty("similarityLimit","double",A),C=function(){const e=r.accordion(),t=r.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(r.span([t,r.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>r.divText("Cliff has not been selected")),!0),s.shell.o=e.root,e}(),k}var pe,me=n(6863),ge=n(2003),fe=n(3516),ye=n(6718),be=n(3077),we=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var ve=n(9192);class Ae{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ce extends O{constructor(e={}){super({...e,enableMCL:!0});const t=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=r.input.int("Similarity cutoff",{value:80}),this.methodsParams[P]=new Ae}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){r.empty(this.activitiesInputRoot);const e=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=r.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return r.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Te,Se,Ee;function Me(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function xe(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}async function Le(e,t,i,o,c,u,h,d=!0,p=!1,m={preprocessingFuncArgs:[]},g={},f=null,y={},b){const w={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==o.length||t.length!==u.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?g.tableView??s.shell.tableView(e.name)??s.shell.addTableView(e):null,A=async()=>{const A=a.TaskBarProgressIndicator.create(`Initializing ${g.scatterPlotName??"dimensionality reduction"} ...`);let C;try{const T=Me(e);function S(n,o,s){let c=null,u=null;e.columns.names().includes(T[0])?(c=e.columns.byName(T[0]),u=e.columns.byName(T[1])):(c=e.columns.add(a.Column.float(T[0],e.rowCount)),u=e.columns.add(a.Column.float(T[1],e.rowCount)),d&&!C&&(C=v.scatterPlot({...w,x:T[0],y:T[1],title:g.scatterPlotName??xe(t,i)}))),g[l.YP]&&(C?.root&&r.setUpdateIndicator(C.root,!1),c.init((e=>s[0]?s[0][e]:void 0)),u.init((e=>s[1]?s[1][e]:void 0)));const h=n/o*100;A.update(h,`Running ${g.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function E(){e.columns.add(a.Column.float(T[0],e.rowCount)),e.columns.add(a.Column.float(T[1],e.rowCount));let n=null;d&&(C=v.scatterPlot({...w,x:T[0],y:T[1],title:g.scatterPlotName??xe(t,i)}),r.setUpdateIndicator(C.root,!0));const p=s.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&C?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===C?.getOptions()?.look?.title&&(s.events.fireCustomEvent(Y,{}),p.unsubscribe(),n?.(),A.close())})),f=new Promise((async(s,r)=>{try{n=s;const r=[];let a=o,d=c,p=h;if(b&&t.every((e=>e.isNumerical))){const n=t.map((e=>e.toList())),i=new Array(e.rowCount).fill(0).map(((e,n)=>new Float32Array(t.length)));for(let o=0;o<t.length;++o)for(let t=0;t<e.rowCount;++t)i[t][o]=n[o][t];m.distanceFnArgs=[{}],r.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,s=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[s]:o[e],...m.preprocessingFuncArgs[e]??{}});r.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};r.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}s(await Z(r.map((e=>e.entries)),i,a,d,h,m,g[l.vb]?void 0:S))}catch(e){r(e)}})),y=await f;return A.close(),p.unsubscribe(),y}const M=await E();if(p&&M){const x=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const L=await function(e,t,i,o){return function(e,t,n,i){return new(n||(n=Promise))((function(o,s){function r(e){try{l(i.next(e))}catch(e){s(e)}}function a(e){try{l(i.throw(e))}catch(e){s(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(r,a)}l((i=i.apply(e,t||[])).next())}))}(this,void 0,void 0,(function*(){return new Promise((function(s,r){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:o,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?r(e):s(t)}}))}))}(M[0],M[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),_=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(_).init((e=>L[e].toString())),C&&(C.props.colorColumnName=_)}catch(I){s.shell.error("Clustering embeddings failed"),console.error(I)}finally{x.close()}}if(M){const P=e.columns.byName(T[0]),N=e.columns.byName(T[1]);if(P.init((e=>M[0][e])),N.init((e=>M[1][e])),f)try{const R=f.inputs[0].name,$=f.inputs[1].name;await f.prepare({[R]:P,[$]:N,...y}).call(!0)}catch(O){s.shell.error("Post-processing failed"),console.error(O)}if(C)return r.setUpdateIndicator(C.root,!1),C.helpUrl="/help/compute/sequence-space",C}}catch(H){s.shell.error("Dimensionality reduction failed"),console.error(H),A.close(),C&&r.setUpdateIndicator(C.root,!1)}};return new Promise((async(t,n)=>{try{if(g.fastRowCount&&e.rowCount>g.fastRowCount&&!g[l.vb])r.dialog().add(r.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await A();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await A();t(e)}}catch(e){n(e)}}))}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Te||(Te={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Se||(Se={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Ee||(Ee={})),Object.prototype.toString;var _e=n(6873),Ie=n(4356),Pe=n(6717),Ne=n(4870),Re=n(3856),$e=n(6882),Oe=n(7278),He=n(5553),ke=n(6642),Fe=n(3599),De=n(673),Ge=n(8312);class Be extends ke.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,ro.logger),(0,ye.pj)().then((e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Ge.Q)().then((e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var Ve=n(4139);const Ue=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class We extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(e){this.seqHandler.column.set(this.rowIdx,e)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===we.YI.DNA}isRna(){return this.seqHandler.alphabet===we.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===we.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(e,t){if(null==t.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=t.column.dataFrame.cell(e,t.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=e,this.seqHandler=t}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const e=(0,Oe.qp)(this.helm),t=[],n=/\(|\)/;for(let i=0;i<e.length;i++){const o=e.getOriginal(i),s=o.split(n).filter((e=>!!e));3===s.length?(t.push(s[0]),t.push(s[1]),t.push(s[2])):t.push(o)}return new Oe.Mu(t,this.seqHandler.defaultGapOriginal)}}const qe=ge.zS;function Ye(e){const t=!R().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,o]of R().enumerate(e)){let s=t;o<e.length&&(s+=`${t?"":"-"}${i}`),n.push(s)}return[n,t]}class je extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=ro.seqHelper}getRendererBack(e){const[t,n,i]=(0,ke.BG)(e);if(n.meta.units!==ge.Hi.CUSTOM)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),o}onClick(e,t){if(e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate(),e.cell.column.meta.units===ge.Hi.CUSTOM){const n=this.getRendererBack(e);n?.onClick(e,t)}}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,He.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe((e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,o,s,r){const[a,l,c]=(0,ke.BG)(s);if(!l)return;const u=l.temp,h=this.seqHelper.getSeqHandler(l);let d=(ro.properties?ro.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in u){const e=u[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new $e.Jy(a,l,ro.logger,d,(()=>{const{font:e,fontWidth:t}=$e.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:h.isMsa()?8:0,monomerToShort:qe}})),l.temp[".mm.cellRenderer.settingsChanged"],De.s.true,p.init().then((()=>{}))),p.render(e,t,n,i,o,s,r)}render(e,t,n,i,o,s,r){if(s.cell.column?.meta?.units!==ge.Hi.CUSTOM)this.renderInt(e,t,n,i,o,s,r);else{const a=this.getRendererBack(s);a?.render(e,t,n,i,o,s,r)}}}class Ke extends Be{constructor(e,t){super(e,t)}render(e,t,n,i,o,s,r){const a=window.devicePixelRatio,l=s.grid,c=s.cell.value??"",u=this.tableCol.tags[ge.gp.separator],h=this.tableCol.meta.units;i=(0,$e.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ue.notationProvider]?.separatorSplitter??(0,Oe.Iv)(h,u),g=m(d),f=m(p),y=R().count(0).take(g.length).map((e=>g.getCanonical(e))).toArray(),b=R().count(0).take(f.length).map((e=>f.getCanonical(e))).toArray(),w=this.tableCol.getTag(ge.gp.alphabet);Ze(e,t,n,i,o,y,b,w===ge.YI.RNA||w===ge.YI.DNA?Fe.o.NUCLEOTIDE:Fe.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new Ke(t,n)),o}}class ze extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ve.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,o,s,r){Ke.getOrCreate(s).render(e,t,n,i,o,s,r)}}function Ze(e,t,n,i,o,s,r,a,l,c,u){if(s.length!==r.length){const e=function(e,t){let n=0,i=0;const o=e.length>t.length?e:t,s=e.length>t.length?t:e;for(let e=0;e<s.length;e++)o[e]===s[e]&&n++;const r=o.length-s.length;for(let e=o.length-1;e>r;e--)o[e]===s[e-r]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(we.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(R()(t).toArray()):e=l(R()(e).toArray()),{subParts1:e,subParts2:t}}(s,r);s=e.subParts1,r=e.subParts2}const h=e.measureText(Ye(s).join("")),d=e.measureText(Ye(r).join("")),p=Math.max(h.width,d.width);c&&(i=p+4*s.length,e.canvas.width=p+4*s.length);let m=Math.max(t,t+(i-(p+4*s.length))/2)+5;const g=Math.max(n,n+(o-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*s.length:i,o),e.clip(),e.font="12px monospace",e.textBaseline="top";const h=7;for(let t=0;t<s.length;t++){const n=s[t],c=r[t];let d=$e.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let s=$e.S$;l&&(s=l.getMonomerTextColor(a,c));const r=(0,Re.oZ)(e,n,m,g-h,i,o,{color:d,pivot:0,left:!0}),p=(0,Re.oZ)(e,c,m,g+h,i,o,{color:s,pivot:0,left:!0});m=Math.max(p,r),u&&(u[t]=Xe(n,c,d,s,g,h,o))}else m=(0,Re.oZ)(e,n,m,g,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Xe(e,t,n,i,o,s,r){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ye([e]).join("")).width,u=l.measureText(Ye([t]).join("")).width,h=Math.max(c,u);return a.height=r,a.width=h+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,o-s,h,r,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,o+s,h,r,{color:i,pivot:0,left:!0}),a}var Je,Qe=n(8070),et=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Je||(Je={}));const tt=new class{constructor(){this.regionTypes=[Je.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=et.fH.Entropy,this.filterSource=et.Fo.filterSource}};var nt=n(7602),it=n(250);const ot=Je;var st,rt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(st||(st={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(rt||(rt={}));const at=tt;class lt extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(rt.skipEmptyPositions,at.skipEmptyPositions,{category:st.DATA}),this.regionTypes=this.stringList(rt.regionTypes,at.regionTypes,{category:st.DATA,choices:Object.values(ot).filter((e=>e!=ot.Unknown))}),this.chains=this.stringList(rt.chains,at.chains,{category:st.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(rt.fitWidth,at.fitWidth,{category:st.LAYOUT}),this.positionWidth=this.float(rt.positionWidth,at.positionWidth,{category:st.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(rt.positionHeight,at.positionHeight,{category:st.LAYOUT,choices:Object.keys(et.fH)}),this.filterSource=this.string(rt.filterSource,at.filterSource,{category:st.BEHAVIOR,choices:Object.values(et.lT)}),this.viewSyncer=new nt.g(ro.logger)}static viewerCounter=-1;viewerId=++lt.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case rt.regionTypes:case rt.chains:this.setData(this.regions)}switch(e.name){case rt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case rt.fitWidth:case rt.positionWidth:this.calcSize();break;case rt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.positionHeight]:this.positionHeight});this.calcSize();break;case rt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;ro.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){ro.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&r.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){ro.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const o of this.chains){const s=t.find((t=>t.order==n[e]&&t.chain==o));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:s.sequenceColumnName,startPositionName:s.positionStartName,endPositionName:s.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,o,t]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of o)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=r.table(this.chains,(e=>[...n.length>0?[r.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",r.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=r.input.choice("Data source",{value:this.filterSource,items:Object.values(et.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=r.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),ro.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){ro.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,o=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[it.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[it.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(rt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[it.n5.filterSource]:this.filterSource})}}}))}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,Qe.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}class ct{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class ut{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const s=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const s=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[s][t].parentJ}return new ut(n,i,s)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ct);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new ct);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>e&&(e=this.dpGrid[i][o].value,t=i,n=o);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}async function dt(e,t,n="Morgan",i=1,o=.6){const s=e.length,r=ro.seqHelper.getSeqHandler(e),a=Array(s);let l=1;const c=new Map,u=e.categories,h=e.getRawData();for(let t=0;t<s;t++){if(null===u[h[t]]||e.isNone(t)){a[t]=null;continue}a[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[t]+=c.get(i)}}let d={};if(t===me.Z.MONOMER_CHEMICAL_DISTANCE||t===me.Z.NEEDLEMANN_WUNSCH){const e=Array.from(c.keys()),s=await(0,ye.A7)(e,n),r={};Object.entries(s.alphabetIndexes).forEach((([e,t])=>{r[c.get(e)]=t}));const l=a.reduce(((e,t)=>Math.max(e,t?.length||0)),0);d={scoringMatrix:s.scoringMatrix,alphabetIndexes:r,maxLength:l},t===me.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var pt=n(4954);function mt(e){const t=r.divH([],{style:{gap:"10px"}}),n=r.divV([r.divText(e.seqCol.name),r.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=r.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(r.divV([r.divText(e.seqCol.get(n)),i]))})),t}function gt(e){const t=r.div();t.append(r.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},o=ro.seqHelper.getSeqHandler(e.seqCol),s=o.defaultBiotype,a=yt(o.getSplitted(e.points[0]),o.getSplitted(e.points[1]),s,i);return t.append(r.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(bt(i)),t.append(ft("Activity delta",Math.abs(n[0]-n[1]))),t.append(ft("Cliff",e.sali)),t}function ft(e,t){return r.divH([r.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),r.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function yt(e,t,n,i){const o=document.createElement("canvas"),s=o.getContext("2d");o.height=30;const r=ro.monomerLib;return Ze(s,0,0,0,30,R().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),R().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),n,r,!0,i),o}function bt(e){const t=r.div();if(Object.keys(e).length>0){const n=r.divV([]);n.append(r.divH([r.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),r.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(r.divH([r.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function wt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class vt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{},nullable:!1}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>{this.gridSelect||this.render(e)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(r.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(e),this.debounceTimer=null}),100)}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(s.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class At extends vt{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[me.Z.NEEDLEMANN_WUNSCH,me.Z.HAMMING,me.Z.LEVENSHTEIN,me.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(e,t){super(e,t),this.distanceMetric=this.string("distanceMetric",me.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const e=this.dataFrame.rowCount;this.preComputeDistanceMatrix=e<=1e4,this.requiresSampling=e>1e4}}needsGapPenalties(){return this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===me.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===me.Z.NEEDLEMANN_WUNSCH}}const Ct={gapPenalty:1,matchScore:1,gapSymbol:we.b9[we.Hi.FASTA],localAlignment:!1};class Tt extends At{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new u.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(e&&!this.gridSelect||t){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init((e=>this.targetColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.targetColumn.getTag(e))));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await s.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe((e=>{n&&clearTimeout(n),(t.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(t)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Ne.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Ne.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const o=s.shell.tv;this.subInited||(o.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const e=this.distanceMetric,n=await dt(this.targetColumn,e,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=t,this.knn=await(new B).getKNN(i,e,t,o)}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=r.div(),n={},i=this.molCol?.name,o=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...Ct,...n},o=e.length,s=t.length,r=Array(o+1).fill(0).map((()=>Array(s+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<o+1;n++)for(let o=1;o<s+1;o++)r[n][o]=Math.max(0,r[n-1][o-1]+(e.getCanonical(n-1)===t.getCanonical(o-1)?i.matchScore:-i.matchScore),r[n-1][o]-i.gapPenalty,r[n][o-1]-i.gapPenalty),r[n][o]>=a&&(a=r[n][o],l=[n,o]);let c=i.localAlignment?l[0]:o,u=i.localAlignment?l[1]:s,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(r[c-1][u-1],r[c-1][u],r[c][u-1]);r[c][u]==r[c-1][u-1]+i.matchScore&&n==r[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):r[c][u]==r[c-1][u]-i.gapPenalty?(d.push(i.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):r[c][u]==r[c][u-1]-i.gapPenalty?(h.push(i.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...R().count(0).take(c).map((t=>e.getCanonical(t))),...h.reverse(),...i.localAlignment?R().count(l[0]).take(o).map((t=>e.getCanonical(t))):[]],d=[...R().count(0).take(u).map((e=>t.getCanonical(e))),...d.reverse(),...i.localAlignment?R().count(l[1]).take(s).map((e=>t.getCanonical(e))):[]];const p=c,m=u;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:h=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Oe.Mu(h,i.gapSymbol),seq2Splitted:new Oe.Mu(d,i.gapSymbol)}}(c,u),d=yt(h.seq1Splitted,h.seq2Splitted,l.defaultBiotype,n);t.append(r.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(r.divV([r.divText("Different sequence length:",{style:{fontWeight:"bold"}}),r.divText(`target: ${c.length} monomers`),r.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(bt(n));const p=r.accordion(),m=r.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(r.span([m,r.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),s.shell.o=p.root}}class St extends At{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new u.Subject;sampledIndices=null;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){await this.computeByMM();const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,t=a.Column.string(e,this.renderMolIds.length).init((e=>this.targetColumn?.get(this.renderMolIds[e])));t.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>t.setTag(e,this.targetColumn.getTag(e))));const n=a.DataFrame.fromColumns([t]);t.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]}));const i=n.plot.grid();(0,Ne.Kd)(i,t.name,450,30),(0,Ne.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length;let t;this.requiresSampling&&e>1e4?(t=this.createRandomSample(e,1e4),this.sampledIndices=t):(t=Array.from({length:e},((e,t)=>t)),this.sampledIndices=null);const n=this.distanceMetric,i=await dt(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,s=i.options,r=t.map((e=>o[e])),a=new G(!0,!1),l=await a.calc(r,n,!0,s);a.terminate();const c=t.length,u=(d=c,(e,t)=>d*e+t-Math.floor((e+2)*(e+1)/2)),h=function(e,t){function n(e,t){let n=null,i=null;for(const o of e){const e=t(o);(null==i||e>i)&&(n=o,i=e)}return n}const i=[(s=e-1,Math.floor(function(e){return Math.random()*e}(s)))],o=new Set;var s;for(let t=0;t<e;++t)i.includes(t)||o.add(t);for(;i.length<t;){const e=n(o.values(),(e=>Math.min.apply(Math,i.map((function(t,n){return l[u(e,t)]})))));null!=e&&(i.push(e),o.delete(e))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=h.map((e=>t[e]))}createRandomSample(e,t){const n=[];for(let t=0;t<e;t++)this.targetColumn.isNone(t)||n.push(t);if(n.length<=t)return n;for(let e=n.length-1;e>0;e--){const t=Math.floor(Math.random()*(e+1)),i=n[e];n[e]=n[t],n[t]=i}return n.slice(0,t)}}var Et,Mt=n(5433),xt=n(3890),Lt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M  RGP",e.ATOM_ALIAS_LINE_START="A  ",e.END="M  END"}(Et||(Et={}));class _t{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const s of[e,t,n])s[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class It extends _t{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pt extends It{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Et.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(Et.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),o=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,s=parseInt(o[n].substring(1));if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,i)}));const s=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==s.length)throw new Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Et.TYPE)&&-1!==e.indexOf(Et.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Et.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Et.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Et.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Et.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Et.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Et.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends It{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const o=t[1];if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M  V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M  END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M  V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Rt{constructor(){}static getInstance(e){if(Rt.isMolfileV2K(e))return new Pt(e);if(Rt.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Pt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var $t=n(6197),Ot=n(9124),Ht=n(3527);class kt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,o=void 0,s=void 0,r){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=o,this.mt=s,this.smiles=r,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++kt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ft extends kt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Dt extends kt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Gt extends kt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Bt extends kt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Vt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,o,s,r,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=o,this.mt=s,this.at=r,this.smiles=a}static fromMonomer(e,t,n){let i={};const o=t.symbol,s=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{i[e.label]=e.capGroupName}));else{if(!s){if(t.lib)return new Bt(e,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(s)}const r=new Vt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(r.textcolor=a?.textcolor,r.linecolor=a?.linecolor,r.backgroundcolor=a?.backgroundcolor),r}}const Ut={[Fe.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Fe.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Fe.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Fe.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Fe.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Fe.o.CHEM]:{R:"#eeeeee"},[Fe.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Wt=/[\w()]+/,qt=RegExp(String.raw`\(${Wt}(,${Wt})+\)`),Yt=e=>{const t=r.canvas(250,250);return s.chem.canvasMol(0,0,250,250,t,e),t},jt=new Ht.Mi([255,255,255]),Kt=new Ht.Mi([0,0,0]),zt=.7*(0,z.wQ)(jt);class Zt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length));for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==we._S||t===we.b9[we.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:R().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{ro.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,Ot.fA)(e,t),o=(0,$t.Y)(n);let s=this.getMonomer(o,i);if(s&&n==Fe.o.LINKER&&2!=s.rgroups.length)return null;if(s&&n==Fe.o.SUGAR&&3!=s.rgroups.length)return null;s||(s=this.addMissingMonomer(o,i));let r=s.wem??null;return r||(i===we._S||"*"==i?r=s.wem=new Ft(n):n===Fe.o.NUCLEOTIDE&&"N"===i||n===Fe.o.AA&&"X"===i||(Fe.o.CHEM,0)||qt.test(i)?r=s.wem=new Dt(n,i):s.lib||(r=s.wem=new Gt(n,i,this.isEmpty)),r||(r=s.wem=Vt.fromMonomer(n,s,this))),r}getTooltip(e,t){const n=(0,$t.Y)(e),i=r.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(e,t),s=this.getMonomer(n,t);if(s){const e=s.symbol,[t,n,a]=(s.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(r.divH([r.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),r.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=s.molfile?Yt(s.molfile):s.smiles?r.divV([Yt(s.smiles),r.divText("from smiles",{style:{fontSize:"smaller"}})]):r.divText("No structure",{style:{margin:"6px"}}),i.append(r.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=we._S){let e=s.lib?.source;e?(e.endsWith(".json")&&(e=e.substring(0,e.length-5)),e=e.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(r.divText(e))):i.append(r.divText("Missed in libraries"))}}else i.append(r.divV([r.divText(`Monomer '${t}' of type '${n}' not found.`),r.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),s=new Ht.Mi([...o.map((e=>e+1))]),r=(0,z.KE)(s,jt)/((0,z.wQ)(s)*(0,z.wQ)(jt)),l=i(n.backgroundcolor),c=new Ht.Mi([...l.map((e=>e+.01))]);let u;u=(0,z.KE)(c,jt)/((0,z.wQ)(c)*(0,z.wQ)(jt))<r?l:o;let h=new Ht.Mi(u);const d=(0,z.wQ)(h);return d>zt&&(h=(0,z.dC)(Kt,h,zt/d)),`rgb(${h[0]}, ${h[1]}, ${h[2]})`}getMonomerColors(e,t){const n="default";let i=n;const o=(0,$t.Y)(e),s=this.getMonomer(o,t);let r;if(s){if(s.meta&&s.meta.colors){if("string"==typeof s.meta.colors)try{s.meta.colors=JSON.parse(s.meta.colors)}catch(e){ro.logger.error(`Bio: MonomerLib.getMonomerColors() failed to parse monomer.meta.colors: ${e}`)}const e=s.meta.colors;e&&"string"!=typeof e&&!(n in e)&&(i="default"),e&&"string"!=typeof e&&i in e&&(r=e[i])}if(!r){const t=Ut[e],n=t?.[s.symbol];n&&(r={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=s.naturalAnalog;if(!r&&t)return this.getMonomerColors(e,t)}return r||(r={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:r.text??r.textColor,linecolor:r.line??r.lineColor,backgroundcolor:r.background??r.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(o+=t[e][n]);n["R"+i]=o,o=""}return n}}var Xt=n(5488),Jt={};Jt.styleTagTransform=C(),Jt.setAttributes=b(),Jt.insert=f().bind(null,"head"),Jt.domAPI=m(),Jt.insertStyleElement=v(),d()(Xt.A,Jt),Xt.A&&Xt.A.locals&&Xt.A.locals;class Qt extends Zt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{ro.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,$t.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Rt.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Ie.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const o=e.duplicateMonomerPreferences[n][i],s=this.duplicateMonomers[n][i].find((e=>e.lib?.source===o));s?this._monomers[n][i]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of R().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}static overrideCounter=0;override(e,t){return new en(e,`override: ${++Qt.overrideCounter}, ${t}`,this)}}class en extends Zt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class tn{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,o){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,ve.AP)(e);this.error=t,this.monomers=[]}}}class nn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var on=n(7433),sn=n.n(on),rn=n(1913),an=n.n(rn);class ln{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(sn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});an()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const o of e){const e=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${o.polymerType??""}-${e}`;i.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(s)}return n}}var cn=n(8604);class un{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let o;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let s=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((e=>o=e))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),s||(s=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++un.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await s.dapi.files.readAsText(cn.gt),o=JSON.parse(i),r=new ln(o);return new un(r,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(cn.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(cn.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(cn.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(cn.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(cn.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),o=await i.readAsText(t);n=JSON.parse(o);const s={},r=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;r.includes(t)||(s[t]={},r.push(t)),s[t][n]=e})),new Qt(s,t)}async loadSetFromFile(e,t,n){let i={};const o=new a.FileSource(t),s=await o.readAsText(n);i=JSON.parse(s);const r=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,o=n.polymerType,s=n.monomerType,r=n.set;return new tn(e,i,o,s,r)}));return new nn(r,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(cn.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${cn.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return ro.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{ro.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void ro.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(cn.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),ro.logger.debug(`${e}, OUT`)})),ro.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(cn.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(cn.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(cn.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(cn.Es.length)))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,H.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class dn{logger;_monomerLib=new Qt({},"MAIN");_monomerSets=new nn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Qe.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++dn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return dn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await un.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Ie.ub)()]),o=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let s=0;const r=o.length,[a]=await Promise.all([Promise.all(o.map((e=>this.readLibrary(cn.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Qt({},e,n)})).finally((()=>{n.update(Math.round(100*++s/r),`Loading monomers ${s}/${r}`)})))))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const o=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(cn.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new nn("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Ie.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,Ie.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}async loadMonomerLibForTests(){await(0,Ie.Eu)(cn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new dn(ro.logger);return e._eventManager=hn.getInstance(),e})()),e}}var pn=n(1757),mn=n.n(pn),gn=n(3017),fn={};fn.styleTagTransform=C(),fn.setAttributes=b(),fn.insert=f().bind(null,"head"),fn.domAPI=m(),fn.insertStyleElement=v(),d()(gn.A,fn),gn.A&&gn.A.locals&&gn.A.locals;var yn=n(3151);class bn{constructor(e,t=[],n={}){this.onItemChanged=new u.Subject,this.onAddingItemChanged=new u.Subject,this.onItemAdded=new u.Subject,this.onItemRemoved=new u.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=r.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,o;if(r.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const o=r.divText(i);o.style.fontWeight="bold",this._root.appendChild(o)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(o=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==o?o:void 0,!0);for(const t of e)this._root.appendChild(t)}}get addingItem(){const e={};return Object.keys(this.addingItemInputs).forEach((t=>{e[t]=this.addingItemInputs[t].value})),e}getItemDiv(e={},t){var n,i;const o=[],s={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):r.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 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Cn,Tn=n(857),Sn={};Sn.styleTagTransform=C(),Sn.setAttributes=b(),Sn.insert=f().bind(null,"head"),Sn.domAPI=m(),Sn.insertStyleElement=v(),d()(Tn.A,Sn),Tn.A&&Tn.A.locals&&Tn.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Cn||(Cn={}));const En={[Cn.MONOMER]:a.COLUMN_TYPE.STRING,[Cn.SYMBOL]:a.COLUMN_TYPE.STRING,[Cn.NAME]:a.COLUMN_TYPE.STRING,[Cn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Cn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Cn.AUTHOR]:a.COLUMN_TYPE.STRING,[Cn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Cn.ID]:a.COLUMN_TYPE.INT,[Cn.META]:a.COLUMN_TYPE.STRING,[Cn.SOURCE]:a.COLUMN_TYPE.STRING};class Mn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(s.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Cn.NAME).width=100,this.tv.grid.col(Cn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=yn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Pn(e,(()=>this.activeMonomerLib),(async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout((()=>{const n=t.col(Cn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await dn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new Mn(e)}return this.instance}static async getNewInstance(){const e=await dn.getInstance();return await e.awaitLoaded(),await e.loadLibrariesPromise,new Mn(e)}async createNewMonomerLib(e,t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await s.dapi.files.writeAsText(cn.so+e,n),await this.monomerLibManamger.loadLibraries(!1),s.shell.v=await this.getViewRoot(e)}catch(e){s.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=r.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=r.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)s.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){s.shell.error("Error creating library"),console.error(e)}o.close()}})).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(s.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(t))})),e.menu.item("Fix all monomers",(()=>{this.fixAllMonomers()})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>Hn(this.tv.dataFrame.rows.get(e)))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(async()=>{const e=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>Hn(this.tv.dataFrame.rows.get(e)))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(async()=>{const e=await Hn(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(s.shell.tableViews??[]).filter((e=>e.name===Mn.VIEW_NAME)).forEach((e=>e.close()))}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(s.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e?s.shell.v=e:Mn.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){s.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach(((e,t)=>{i[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((e=>e.length>0));const o=r.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=r.iconFA("wand-magic",(()=>{this.fixAllMonomers()}),"Fix all monomers"),c=r.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),u=r.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=await Promise.all(t.map((e=>Hn(this.tv.dataFrame.rows.get(e)))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=await Hn(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));r.tooltip.bind(u,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const h=r.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return s.shell.error("No library selected");let t=null;try{t=await s.dapi.files.readAsText(cn.so+e)}catch(t){return s.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return s.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");i.push([o,c,l,u,h]),this.tv.setRibbonPanels(i),this.tv.name=Mn.VIEW_NAME,this.libInput=r.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(r.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),r.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(e){return this._newMonomer=await Hn(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{return e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(cn.so,e),this.activeMonomerLib?function(e){try{const t=e.getPolymerTypes().flatMap((t=>e.getMonomerSymbolsByType(t).map((n=>e.getMonomer(t,n))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const o=Array.from(i);o.sort();for(const[e,t]of Object.entries(En))if(n.columns.addNew(e,t),e===Cn.R_GROUPS)for(const e of o)n.columns.addNew(e,a.COLUMN_TYPE.STRING);n.col(Cn.SYMBOL).semType="Monomer",n.col(Cn.SYMBOL).setTag(Re.Mn.applyToBackground,"true");for(let e=0;e<t.length;e++){let i=Rn(t[e].rgroups,t[e].smiles,t[e].molfile);i=xn(i),t[e].rgroups=In(t[e].rgroups);const s=o.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?_n(i,"capGroupSmiles"):""}));let r=null;if(t[e].createDate)try{r=Date.parse(t[e].createDate)}catch(n){console.error(`Error parsing date ${t[e].createDate}`)}n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...s,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,r,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""]);try{r&&n.col(Cn.CREATE_DATE)?.set(e,r,!1)}catch(n){console.error(`Error setting date ${t[e].createDate}`,n)}}return n.col(Cn.MONOMER).semType=a.SEMTYPE.MOLECULE,o.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n}catch(e){throw s.shell.error("Error creating monomers dataframe"),console.error(e),e}}(this.activeMonomerLib):(s.shell.error(`Library ${e} not found`),a.DataFrame.create())}catch(e){throw s.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){r.dialog("Fix All Monomers").add(r.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(r.divText("Do you wish to continue?")).onOK((async()=>{const e=this.tv?.dataFrame;let t=this.libInput.value;if(e&&t){this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(e.rowCount).fill(0).map(((t,n)=>Hn(e.rows.get(n))))),i=JSON.stringify(n.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await s.dapi.files.writeAsText(cn.so+t,i),await this.monomerLibManamger.loadLibraries(!0),s.shell.v=await this.getViewRoot(t)}catch(e){s.shell.error("Error saving library"),console.error(e)}finally{this.tv?.grid&&r.setUpdateIndicator(this.tv.grid.root,!1)}}else s.shell.error("No monomer library loaded")})).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function xn(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const Ln=["alternateId","capGroupName","capGroupSMILES","label"];function _n(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function In(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(Ln,e),n=_n(t,"capGroupSMILES"),i=_n(t,"alternateId"),o=_n(t,"capGroupName"),s=_n(t,"label")??"R1";if(n&&i&&o||s.length<2)return t;if(i&&-1!==i.indexOf(`${s}-`)){const e=i.replace(`${s}-`,"");o||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${s.substring(1)}][${e}]`)}else o&&(n||(t.capGroupSMILES=`[*:${s.substring(1)}][${o}]`),i||(t.alternateId=`${s}-${o}`));return t})).sort(((e,t)=>e.label?.localeCompare(t.label??"")??0))}class Pn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new kn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=r.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=r.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=r.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=r.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=r.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=r.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=r.bigButton("Save",(async()=>{const e=this.validateInputs();e?s.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=Rn([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((e=>e[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items=i.sort(((e,t)=>e.label?.localeCompare(t.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await An(On(t,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new bn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?s.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=r.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new bn(l,[]),this.onMonomerInputChanged();const c=r.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=r.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:r.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=In(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter((([e,t])=>"colors"!==e?.toLowerCase())).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!e.naturalAnalog&&e.polymerType&&An(On(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}));const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=r.buttonsInput([this.saveButton]);return r.tooltip.bind(e,(()=>this.saveValidationResult??"Save monomer to library")),r.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=Rn(e.rgroups,e.smiles,e.molfile),n=s.chem.drawMolecule(t,150,150),i=r.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return r.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await s.dapi.files.readAsText(cn.so+t);i=JSON.parse(e)}catch(e){return s.shell.error(`Error reading library ${t}`),console.error(e)}const o=e.map((e=>Nn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<o.length;n++)if(-1===o[n])return void s.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=o.map((e=>i[e])),l=r.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,u=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,h=r.dialog("Remove Monomer"+(c?"s":"")).add(r.h1(u)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await s.dapi.files.writeAsText(cn.so+t,JSON.stringify(i,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&s.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),h.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await s.dapi.files.readAsText(cn.so+t);n=JSON.parse(e)}catch(e){return s.shell.error(`Error reading library ${t}`),console.error(e)}const i=Nn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),o=this.getMonomersDataFrame()?.col(Cn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{const i=n.findIndex((t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await s.dapi.files.writeAsText(cn.so+t,JSON.stringify(n,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,s.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){s.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const e=await Hn(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=r.dialog("Save Monomer").add(r.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!s.chem.checkSmiles(e))return void s.shell.warning("Invalid SMILES");e=Rn([],e);let t=s.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=$n(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},r=this.getMonomerLib()?.source;r?await this.addMonomerToLib(o,r):s.shell.warning("Monomer library source is not specified")}}function Nn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function Rn(e,t,n){const i=!t||!s.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?s.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return o=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(o,e),o=xn(o),i?o:s.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function $n(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")));if(-1===i)return console.error("Mol start line not found"),e;const o=Number.parseInt(t[i].trim().split(" ")[0].slice(0,3).trim()),s={};for(let e=i+1;e<i+1+o;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const o=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(s[e-i]=1,o.length<14)continue;const r=Number.parseInt(o[13]);Number.isNaN(r)||(s[e-i]=r)}const r=Object.keys(s);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M  RGP${r.length.toString().padStart(3," ")}${Object.entries(s).map((([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`)).join("")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return r.filter((e=>!!Number.parseInt(e))).map((e=>Number.parseInt(e)+i)).forEach((e=>{const n=t[e].split(" "),i=n.findIndex((e=>"R#"===e));if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}})),t.join("\n")}function On(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=_n(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}async function Hn(e){let t;try{t=JSON.parse(e.get(Cn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e])),("string"!=typeof t[e]||t[e]!==a.INT_NULL.toString()&&t[e]!==a.FLOAT_NULL.toString())&&("number"!=typeof t[e]||t[e]!==a.INT_NULL&&t[e]!==a.FLOAT_NULL)||(t[e]=null)}catch(e){console.error(e)}const n=e.get(Cn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=s.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=$n(i)}catch(e){s.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}let o=e.get(Cn.NATURAL_ANALOG);const r=e.get(Cn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(e.get(Cn.R_GROUPS)??"[]"),!o&&r){const e=await An(On(n,l),r);e&&(o=e)}}catch(e){l??=[]}return{symbol:e.get(Cn.SYMBOL),name:e.get(Cn.NAME),molfile:i,smiles:n,polymerType:r,monomerType:e.get(Cn.MONOMER_TYPE),naturalAnalog:o,id:e.get(Cn.ID),rgroups:l,meta:t,author:e.get(Cn.AUTHOR),createDate:e.get(Cn.CREATE_DATE)}}class kn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:r.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:r.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:r.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return r.form(Object.values(this._colorInputs))}}class Fn{monomer;root=r.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){r.empty(this.root);const e=this.monomer.smiles&&s.chem.checkSmiles(this.monomer.smiles)?s.chem.drawMolecule(this.monomer.smiles,200,200):s.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=r.divH([r.divText("Monomer Name: "),r.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),r.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=r.divH([r.divText("Source: "),r.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),r.tooltip.bind(e,this.monomer.lib.source)}const n=r.divH([r.divText("Polymer Type: "),r.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),r.tooltip.bind(n,this.monomer.polymerType),r.tooltip.bind(this.root,"Select Monomer")}}class Dn{monomerSymbol;monomers;root=r.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Fn(e)));const o=r.divH([],{style:{overflowX:"auto",width:"100%"}}),s=r.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});r.tooltip.bind(s,e),this.root.appendChild(s),this.root.appendChild(o),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),o.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Gn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Gn._instance||(Gn._instance=new Gn,await Gn._instance.refresh(),(await dn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Gn._instance.refresh()))),Gn._instance.refresh(),Gn._instance}async refresh(){this.settings=await(0,Ie.ub)();const e=await dn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,o=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new Dn(n,this.monomers[t][n],o,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Ie.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),s.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`))}))})))}const t=r.divText("Set Default");if(t.addEventListener("click",(async()=>{if(0===Object.keys(this.monomers??{}).length)return void s.shell.info("No Duplicate Monomers found");const t=new Set;for(const e in this.monomers)for(const n in this.monomers[e])for(const i of this.monomers[e][n])i.lib?.source&&t.add(i.lib.source);if(0===t.size)return void s.shell.info("No Duplicate Monomers found");const n=Array.from(t),i=r.input.choice("Default Library",{items:n,nullable:!0});r.dialog("Set Default Monomer Source for Duplicates").add(i).onOK((async()=>{if(i.value){for(const e in this.monomers)for(const t in this.monomers[e]){const n=this.monomers[e][t];n?.some((e=>e.lib?.source===i.value))&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][t]=i.value)}await(0,Ie.Eu)(this.settings),e.assignDuplicatePreferances(this.settings),s.shell.info(`Default Monomer Source for Duplicates set to '${i.value}'.`),setTimeout((()=>this.refresh()),100)}else s.shell.info("No library selected")})).show()})),this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=r.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=r.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.addOptions(t),this.searchInput.input.style.width="200px",this._root=r.divV([r.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,r.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Bn(){await qn.showDialog()}async function Vn(e=!0){return await Yn.showView(e)}class Un{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Un.instancePromise&&(Un.instancePromise=(async()=>{const e=new Un,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Un.instancePromise}static async reloadWidget(){const e=await Un.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await Wn.createControlsForm();return mn()(e).addClass("monomer-lib-controls-form"),setTimeout((()=>{e&&mn()(e)&&mn()(e).removeClass("ui-form-condensed")}),200),r.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){s.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Wn{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([e,t])=>{this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){ro.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then((e=>e.getFileManager())),await(0,Ie.ub)()]);return new Wn(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=r.wideForm(e,void 0);return mn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();mn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;ro.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=r.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});r.tooltip.bind(i.root,`Include monomers from ${e}`);const o=r.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=r.icons.edit((async()=>{s.shell.v=await(await Mn.getInstance()).getViewRoot(e)}),"Edit monomer library");return r.tooltip.bind(o,`Delete ${e}`),i.addOptions(a),i.addOptions(o),ro.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Ie.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),s.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){r.dialog("Warning").add(r.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),s.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class qn{constructor(){}static _instance;dialog;closeDialogSubject$=new u.Subject;static async showDialog(){qn._instance||(qn._instance=new qn,qn._instance.closeDialogSubject$.subscribe((()=>{qn._instance.dialog=void 0}))),qn._instance.dialog||(qn._instance.dialog=await qn._instance.getDialog()),qn._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Un.getInstance()).widget,n=r.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});mn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class Yn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Un.getInstance()).widget,i=r.bigButton("Add",(()=>t.addLibraryFile()),"Upload new HELM monomer library"),o=r.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=r.splitH([r.divV([n.root,r.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach((e=>e.unsubscribe())),this._view.detach(),this._view.close()}catch(e){}return this._view=a.View.fromRoot(l),this._view.name=Yn.viewName,e&&s.shell.addView(this._view),r.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const e=Array.from(l.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const s=i-o;n.style.width=`${s}px`}),100),this._view.subs.push(s.events.onCurrentViewChanged.subscribe((()=>{try{const e=Yn._instance;e&&e._view&&s.shell.v&&"id"in s.shell.v&&s.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))})),this._view}static async showView(e=!0){return Yn._instance||(Yn._instance=new Yn),Yn._instance._duplicateManager||(Yn._instance._duplicateManager=await Gn.getInstance()),Yn._instance.libManager||(Yn._instance.libManager=await dn.getInstance()),e&&Yn._instance._view&&Array.from(s.shell.views).find((e=>e.id&&e.id===Yn._instance._view.id))?(s.shell.v=Yn._instance._view,await Yn._instance._duplicateManager.refresh(),Yn._instance._view):(Yn.closeExistingViews(),Yn._instance.getView(e))}static closeExistingViews(){Array.from(s.shell.views).filter((e=>e.name===Yn.viewName)).forEach((e=>e.close()))}async mergeSelectedLibs(){const e="Library with this name already exists",t=await dn.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void s.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=r.dialog("Merge selected libraries"),o=r.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=u(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=o.value;return e.endsWith(".json")||(e+=".json"),e}function u(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}o.addValidator(u),i.add(o).add(r.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&r.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(t,e,!1);const n=await(0,Ie.ub)();n.exclude=l,await(0,Ie.Eu)(n),await this.libManager.loadLibraries(!0),await Un.reloadWidget()}catch(t){s.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&r.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var jn,Kn=function(e,t,n,i){return new(n||(n=Promise))((function(o,s){function r(e){try{l(i.next(e))}catch(e){s(e)}}function a(e){try{l(i.throw(e))}catch(e){s(e)}}function l(e){var t;e.done?o(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(r,a)}l((i=i.apply(e,t||[])).next())}))};class zn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=r.breadcrumbs(n);if(i.onPathClick.subscribe((e=>Kn(this,void 0,void 0,(function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=s.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find((e=>e.text===t))})))),s.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=r.iconFA("home",(()=>{s.shell.v.close(),s.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=s.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var o,s;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._stopStartBtn=r.button(r.iconFA("pause"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=r.button(r.iconFA("redo"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=r.button(r.iconFA("play"),(()=>Kn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._closeBtn=r.button(r.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(s=null==i?void 0:i.path)&&void 0!==s?s:"",this._progress.max=0,this._progress.value=1,zn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=r.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(r.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=r.iconFA("clock");this._isAutomatic||0===t&&(n=r.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=r.div(this._steps[t].name,"grok-tutorial-entry-instruction"),o=r.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=r.divH([n,i],"grok-tutorial-entry");this._activity.append(s,o)}}_initRoot(){s.shell.windows.showContextPanel=!0,s.shell.windows.showHelp=!1,this._node=s.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,s.shell.dockManager.findNode(s.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;s.shell.v&&(s.shell.v.name=this.name,s.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Kn(this,void 0,void 0,(function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Qe.cb)(c));const u=r.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=r.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}s.shell.v instanceof a.TableView&&(yield s.data.detectSemanticTypes(s.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Kn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Kn(this,void 0,void 0,(function*(){const i=r.div([],"demo-script-countdown");t.classList.add("hidden");let o=n/1e3;const s=this._createSVGIndicator(o);i.append(s),e.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return Kn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Kn(this,void 0,void 0,(function*(){s.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=r.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=r.panel([],"tutorials-main-header"),this._header=r.h2(""),this._headerDiv=r.divH([],"tutorials-root-header"),this._activity=r.panel([],"tutorials-root-description"),this._progressDiv=r.divV([],"tutorials-root-progress"),this._progress=r.element("progress"),this._progressSteps=r.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){s.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,zn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Kn(this,void 0,void 0,(function*(){this._initRoot(),s.shell.v.name===this.name&&(s.shell.v.close(),this._node=s.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,s.shell.dockManager.findNode(s.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}zn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(jn||(jn={}));var Zn=n(966),Xn=n(608),Jn=n(1619);class Qn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=R()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=s.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${ro.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case it.n5.fixWidth:case it.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ei{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=r.input.table("Table",{value:s.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=r.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=r.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ti=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ni="-";class ii extends Be{constructor(e,t){super(e,t)}render(e,t,n,i,o,s,r){e.save(),e.beginPath(),e.rect(t,n,i,o),e.clip();try{if(!s.isTableCell)return;const r=s.cell?.column&&s.cell.column?.dart&&"true"===s.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="left";let a=s.cell.value;a&&a!==we._S||(a=ni);const l=a.split(we.ot).map((e=>e&&e!==we._S?e.trim():ni)),c=l.map((e=>(0,ge.zS)(e,Math.max(2,Math.floor(.15*i/l.length))))),u=c.map((t=>e.measureText(t).width)),h=u.reduce(((e,t)=>e+t),0);let d=t+(i-h)/2;const p=this.tableCol.getTag(we.gp.alphabet),m=p===ge.YI.RNA||p===ge.YI.DNA?ti.o.NUCLEOTIDE:ti.o.AA;for(let s=0;s<c.length;s++){const a=l[s];let h=$e.S$,p="rgb(255, 255, 255)";if(this.monomerLib)if(r){const e=this.monomerLib.getMonomerColors(m,a);h=e?.textcolor??h,p=e?.backgroundcolor??p}else h=this.monomerLib.getMonomerTextColor(m,a);r&&1==l.length&&(e.fillStyle=p,e.fillRect(t,n,i,o)),e.fillStyle=h,e.fillText(c[s],d,n+o/2,i),d+=u[s]}}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(we.gp.alphabet),i=e.cell.value,o=e.grid.canvas.getBoundingClientRect(),s=e.bounds.right+o.left-4,a=e.bounds.bottom+o.top-4;if(!i||i==we._S||i==ni)return r.tooltip.show(r.divText("gap"),s,a),!0;if(!this.monomerLib)return r.tooltip.show(r.divText("Monomer library is not available."),s,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ti.o.NUCLEOTIDE:ti.o.AA,c=i.split(we.ot).map((e=>e&&e!==we._S&&e!==ni?this.monomerLib.getTooltip(l,e):r.divText("gap"))),u=r.divH(c,{style:{alignItems:"top"}}),h=Array.from(u.querySelectorAll("canvas"));if(h.length>2){const e=Math.floor(550/h.length);h.forEach((t=>{t.style.setProperty("max-width",`${e}px`,"important"),t.style.setProperty("max-height",`${e}px`,"important")}))}return r.tooltip.show(u,s,a),!0}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,ke.BG)(e);let o=i.rendererBack;return o||(o=i.rendererBack=new ii(t,n)),o}}class oi extends a.GridCellRenderer{get name(){return Ve.uF.MONOMER}get cellType(){return Ve.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,o,s,r){ii.getOrCreate(s).render(e,t,n,i,o,s,r)}onMouseMove(e,t){ii.getOrCreate(e).onMouseMove(e,t)}}class si{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ri extends Map{_onPropertyChanged=new u.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new si(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ve.AP)(e);s.shell.error(t),this.logger.error(t,void 0,n)}}var li=n(5999),ci={};ci.styleTagTransform=C(),ci.setAttributes=b(),ci.insert=f().bind(null,"head"),ci.domAPI=m(),ci.insertStyleElement=v(),d()(li.A,ci),li.A&&li.A.locals&&li.A.locals;var ui=n(6307);class hi extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(e,t){super(r.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=ro.properties.tooltipWebLogo,n=this.seqCol.getTag(et.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function di(e,t,n,i){const o=ro.seqHelper.getSeqHandler(e);let s=null,r=null;for(let e=0;e<o.posList.length;++e)o.posList[e]==t&&(s=e),o.posList[e]==n&&(r=e);if(null===s&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===r&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<r)throw new Error(`End position ${r} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return o.getRegion(s,r,a)}const pi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class mi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??pi;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await s.data.detectSemanticTypes(this.data.df),this.view=s.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${ro.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class gi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=r.input.table("Table",{value:this.call.inputParams.table.value??s.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=r.input.column("Sequence",{table:s.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=r.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=r.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=r.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=r.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)r.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),o=document.createElement("option");t.text=o.text=e,t.value=o.value=e,n.options.add(t),i.options.add(o)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const o=e.options[i],s=JSON.parse(o.value);s&&t===s.start&&n===s.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=r.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});r.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{ro.handleErrorUI(e)}))})).show()}widget(){const e=r.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=r.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{ro.handleErrorUI(e)}))}));return a.Widget.fromRoot(r.divV([e,r.div(t)]))}}var fi=n(8754);async function yi(e,t,n,i,o){const s=await async function(e,t,n,i,o){const s=(0,be.R)(t,o),r=o.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(r).getSplitted(0),c=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),o=new Array(n),s=new Array(n);for(let r=0;r<n;++r){const n=t.columns.byIndex(r);i[r]=n.getRawData(),o[r]=n.categories.indexOf("");const a=r<e.length?e.getOriginal(r):we._S;s[r]=n.categories.indexOf(a)}const r=a.Column.float("Identity",t.rowCount),l=r.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===s[t]&&++l[n];l[n]/=e.length}return r}(l,s):i===pe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,ye.uL)(i,e,n)}(l,s,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,o);for(let e=0;e<s.length;e++)t.isNone(e)&&s.set(e,null,!1);return s}var bi=n(294),wi=n(330);const vi=OCL;var Ai=n(2582);class Ci{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)return;const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var Ti=n(6956);class Si{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===Ti.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Ei{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,o=n*Math.cos(e)-i*Math.sin(e),s=n*Math.sin(e)+i*Math.cos(e);if(isNaN(o)||isNaN(s))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:o,y:s}}))}}class Mi extends Ei{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class xi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,o)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:o})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class Li extends xi{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class _i extends Ci{constructor(e,t){super(t);const n=Rt.getInstance(e);this.atoms=new Mi(n),this.bonds=new Li(n),this.rGroups=new Si(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends Ei{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const o=this.coordinates[i],s=o.x.toFixed(4)+"00",r=o.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,o,a)=>t+s+i+r+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M  ${n.slice(0,7).join(" ")}`)}}class Pi extends xi{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,o,s,r)=>`${n}${t[0]}${o}${t[1]}${r}`))}))}}class Ni extends Ci{constructor(e,t){super(t);const n=Rt.getInstance(e);this.atoms=new Ii(n),this.bonds=new Pi(n),this.rGroups=new Si(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ri{static getInstance(e,t){if(Rt.isMolfileV2K(e))return new _i(e,t);if(Rt.isMolfileV3K(e))return new Ni(e,t);throw new Error("Unsupported molfile version")}}class $i{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,o,s){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=s;const r=this.getLibraryMonomerObject();let a=r.molfile;Rt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,o)),this.molfileWrapper=Ri.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(r),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if($i.molfileV2KToV3KCache.has(e))return $i.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return $i.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Oi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new Ai.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===we.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,o=new $i(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new bi.Cg;for(const[n,o]of R().enumerate(this.monomerWrappers)){const s=e.length,r=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Fe.o.NUCLEOTIDE:Fe.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:R().count(s).take(n.atomCount).toArray(),bonds:R().count(r).take(n.bondCount).toArray()})}const o=e.length,s=t.length;return{molfile:[this.getV3KHeader(o,s),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,o)=>t+i+o))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,o)=>t+i+o))})),"M  V30 END BOND"].join("\n")}}class Hi{constructor(e){this.molfileHandler=Rt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class ki{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,o=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return vi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,ve.AP)(e);return ro.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;o.update(t,`${t?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const o=e.dataFrame,s=this.convertToMolfileV3KColumn(e).toList().map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),r=`molfile(${e.name})`,l=o?o.columns.getUnusedName(r):r;return t?this.getMolV3000ViaOCL(s,l):a.Column.fromStrings(l,s.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map((e=>e.molfile)),i=(0,wi.kA)(t,`molfileV3K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=bi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,ve.AP)(e);ro.logger.error(t,void 0,n),o=bi.vF.createEmpty()}t[n]=o}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const o=this.helmHelper.getMolfiles([n])[0],s=new Hi(o),r=new Oi(n,this.rdKitModule,this.monomerLib);s.monomerSymbols.forEach(((e,t)=>{const n=s.getMonomerShifts(t);r.addMonomer(e,t,n)}));const a=r.compileToMolfile(),l=new bi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new bi.vF(a.molfile,l)}}class Fi{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ue.notationProvider]??null);const i=this.isFasta()?we.b9[ge.Hi.FASTA]:this.isSeparator()?we.b9[ge.Hi.SEPARATOR]:this.isHelm()?we.b9[ge.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??we.b9[ge.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||e.temp.seqHandlerRefined||(this.refineSeparatorNotation(),e.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const e=((e,t,n)=>{const i={};let o=!0,s=null;for(const t of e){const e=t?n(t):[];if(null===s?s=e.length:e.length!==s&&(o=!1),e.length>=3)for(const t of e)t in i||(i[t]=0),i[t]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?R().count(0).take(Math.min(100,this.column.length)).map((e=>this.column.get(e))):this.column.categories.slice(0,100)).map((e=>e?e.substring(0,500):"")).filter((e=>0!==e.length)))],0,(e=>e.split(this.separator)));let t=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const o=n[0].prepare({col:this.column,stats:e,separator:this.separator}),s=(await o.call()).getOutputParamValue();t||=s}catch(e){console.error(e)}t&&(delete this.column.temp[Ue.seqHandler],this.column.fireValuesChanged())}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,Oe.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,Oe.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?Fe.o.NUCLEOTIDE:Fe.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getMonomerAtPosition(e,t,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(e)??"")[t];return n?i===we.b9[ge.Hi.FASTA]?we._S:i??we._S:i??""}const i=this.getSplitted(e);return t<0||t>=i.length?this.defaultGapOriginal:n?i.getCanonical(t):i.getOriginal(t)}getMonomersAtPosition(e,t){const n=this.column.length,i=new Array(n).fill(we._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,s=this.column.getRawData();for(let r=0;r<n;r++){const n=o[s[r]]??"";if(e<n.length){const o=n[e];i[r]=t?o===we.b9[ge.Hi.FASTA]?we._S:o??we._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);e>=0&&e<n.length&&(i[o]=t?n.getCanonical(e):n.getOriginal(e))}return i}getValue(e,t){return this.column.get(e),new We(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get isCanonicalAlphabet(){const e=this.alphabet;return e===ge.YI.DNA||e===ge.YI.RNA||e===ge.YI.PT}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:R().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)).reduce(((e,t)=>e>t?e:t),0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map((e=>e.trim())):R().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const o=this.column,s=e.toLowerCase()+"("+o.name+")",r=n??o.dataFrame?.columns.getUnusedName(s)??s,l=a.Column.fromList("string",r,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=o.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let u=o.getTag(ge.gp.alphabet);u||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(u=ge.YI.UN),null!=u&&l.setTag(ge.gp.alphabet,u);let h=o.getTag(ge.gp.alphabetSize);null!=u&&h&&l.setTag(ge.gp.alphabetSize,h);const d=o.getTag(ge.gp.alphabetIsMultichar);return null!=u&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,h)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!Fi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:Oe.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return me.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return me.Z.LEVENSHTEIN}getDistanceFunction(){return me.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,ye.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let e=0;e<i;++e){const i=o[e];if(!(i in n)){n.add(i);const o=this.getSplitted(e);for(let e=0;e<o.length;++e){const n=o.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?we.b9[ge.Hi.FASTA]:we.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const o=e.startsWith("RNA"),s=(0,ge.qp)(e),r=[];for(let e=0;e<s.length;++e){let n=s.getOriginal(e);if(o&&(n=n.replace(yn.EK,"$1")),n===we.b9[ge.Hi.HELM])r.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";r.push(e)}else r.push(n)}return r.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=e??0,s=t??this.maxLength-1,r=this.getJoiner(),a=s-o+1,l=we.b9[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t.getOriginal(i):l}return r(new Oe.Mu(n,l))}));const c=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(a);for(let e=0;e<a;++e){const i=o+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},u=this.column.getTag(ge.gp.positionNames);u&&i.setTag(ge.gp.positionNames,c(u));const h=this.column.getTag(ge.gp.positionLabels);return h&&i.setTag(ge.gp.positionLabels,c(h)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const o=this;switch(t){case ge.Hi.FASTA:i=function(e){return o.joinToFasta(e,o.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Di(e,n,o.isHelm())};break;case ge.Hi.HELM:{const e=o.alphabet===ge.YI.DNA||o.alphabet===ge.YI.RNA,t=o.getHelmWrappers();i=function(n){return Gi(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e,t){let n=e.temp[Ue.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Ue.seqHandler]=new Fi(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const o=e.getOriginal(i);let s=e.getOriginal(i);t&&(s=s.replace(yn.EK,"$1")),o===we._S?s=we.b9[ge.Hi.FASTA]:o===yn.q7?s="":s.length>1&&(s="["+s+"]"),n[i]=s}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Di(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return Gi(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(let e=0;e<t.length;++e){let s=t.getOriginal(e);(i||o)&&(s=s.replace(yn.EK,"$1"),s=s===yn.q7?null:s),n[e]=s||null}return new Oe.Mu(n.filter((e=>!!e)),we.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(e,t)),i}}function Di(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const o=e.getCanonical(t);let s=e.getOriginal(t);n&&(s=s.replace(yn.EK,"$1")),o===we._S?s=we.b9[ge.Hi.SEPARATOR]:o===yn.q7&&(s=""),i[t]=s}return i.join(t)}function Gi(e,t,n){const[i,o,s,r]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let r=e.getOriginal(t);i===we._S?r=we.b9[ge.Hi.HELM]:(n&&(r=r.replace(yn.EK,"$1")),r=1===r.length?`${o}${r}${s}`:`${o}[${r}]${s}`),a[t]=r}return`${i}${a.join(".")}${r}`}class Bi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return Fi.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Ot.b2)();return new ki(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return bi.vF.createEmpty();const o=t.convertToMolfileV3K([e])[0];if(!o||!o.molfile)return bi.vF.createEmpty();let s=null;try{let e=o.molfile;if(i){if(s=this.rdKitModule.get_mol(e),!s)return bi.vF.createEmpty();s.set_new_coords(),s.normalize_depiction(1),s.straighten_depiction(!0),e=s.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new bi.vF(e,o.monomers)}catch(e){const[t,n]=(0,ve.AP)(e);return ro.logger.error(t,void 0,n),bi.vF.createEmpty()}finally{s?.delete()}}async helmToAtomicLevel(e,t,n,i){const o=i??this.libHelper.getMonomerLib(),r=e.dataFrame,l=(0,wi.qj)(r,e.name),c=await this.getHelmToMolfileConverter(o),u=e.toList(),h=new Array(e.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(u[n],c,t&&!p,!d).molfile;if(d){const t=await d.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}if(t&&p){const t=await p.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n]);else s.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,h);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",e.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,Fi.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.SEPARATOR)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),Fi.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,Fi.setTags(e)}}async function Vi(e){let t="";try{if(!e||!e.value)return t="No sequence provided",{errorText:t,mol:""};if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t="Atomic level conversion requeires a sequence column",{errorText:t,mol:""};if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].includes(e.cell.column.meta.units?.toLowerCase()??""))return t="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:t,mol:""};const n=(await lo.getSeqHelper()).getSeqHandler(e.cell.column);if(!n)return t="No sequence handler found",{errorText:t,mol:""};if((n.getSplitted(e.cell.rowIndex,50)?.length??100)>40)return t="Maximum number of monomers is 40",{errorText:t,mol:""};const i=a.Column.fromStrings("singleVal",[e.value]),o=a.DataFrame.fromColumns([i]);if(Object.entries(e.cell.column.tags).forEach((([e,t])=>{i.setTag(e,t)})),await lo.toAtomicLevel(o,i,e.cell.column.meta.units===ge.Hi.HELM,!1),o.columns.length<2)return t="No structure generated",{errorText:t,mol:""};const s=o.columns.byIndex(1).get(0);return s?{errorText:"",mol:s}:(t="No structure generated",{errorText:t,mol:""})}catch(e){ro.logger.error(e)}return t="No Structure generated",{errorText:t,mol:""}}const Ui="#333333",Wi="rgba(60, 177, 115, 0.1)",qi="rgba(240, 240, 240, 0.5)",Yi="rgba(100, 100, 100, 0.3)";class ji{constructor(e=Zi.DEFAULT_TRACK_HEIGHT,t=Zi.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=e,this.defaultHeight=e,this.minHeight=t,this.title=n}init(e){this.ctx=e}getMonomerAt(e,t,n){return null}enableTooltip(e){this.tooltipEnabled=e}setTooltipContentGenerator(e){this.tooltipContent=e}getTooltipContent(e,t){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(e)??new Map;return this.tooltipContent(e,t,n)}getPositionData(e){return null}setVisible(e){this.visible=e}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(e){this.height=Math.max(this.minHeight,e)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(e){this.title=e}getTitle(){return this.title}}class Ki extends ji{constructor(e=new Map,t=Zi.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(t,Zi.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=e,this.visible=e.size>0}setHovered(e,t){this.hoveredPosition=e,this.hoveredMonomer=t}getPositionData(e){return this.data.get(e)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator(((e,t,n)=>this.createTooltipContent(e,t,n)))}createFrequencyTable(e){let t;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":t=Fe.o.NUCLEOTIDE;break;default:t=Fe.o.AA}const n=Array.from(e.values()).reduce(((e,t)=>e+t),0),i={};for(const[t,o]of e.entries())i[t]=Math.max(1,Math.round(o/n*100));const o=(0,ui.F)(i,t,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(e,t,n){const i=[];if(i.push(r.divText(`Position: ${e+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),t&&(i.push(r.divText(`Monomer: ${t}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(t)&&i.push(r.divText(`${(100*n.get(t)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const e=this.createFrequencyTable(n);i.push(e)}else i.push(r.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=r.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(e){this.monomerLib=e}setBiotype(e){this.biotype=e}getMonomerAt(e,t,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=t,s=Array.from(i.entries()).sort(((e,t)=>t[1]-e[1])),r=s.reduce(((e,[t,n])=>e+n),0),a=this.height;let l=0;for(const[e,t]of s){const n=t*a/r;if(o>=l&&o<l+n)return e;l+=n}return null}updateData(e){this.data=e,this.visible=e.size>0}draw(e,t,n,i,o,s,r,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/s),c=i-4,u=t+2;for(let h=0;h<l;h++)this.drawWebLogoColumn(h,e,t,n,i,o,s,r,a,u,c)}drawWebLogoColumn(e,t,n,i,o,s,r,a,l,c,u){const h=s+e-1;if(h<0||h>=a)return;const d=this.data.get(h);if(!d||0===d.size)return;const p=t+e*r,m=r-2;s+e===l&&(this.ctx.fillStyle=Wi,this.ctx.fillRect(p,n,r,o)),this.ctx.fillStyle=qi,this.ctx.fillRect(p+1,c,m,u),this.drawLettersInColumn(h,p,m,c,u,d),this.drawColumnBorder(p,c,m,u)}drawLettersInColumn(e,t,n,i,o,s){const r=Array.from(s.entries()).sort(((e,t)=>t[1]-e[1])),a=r.reduce(((e,[t,n])=>e+n),0),l=Math.min(1,o/(a*o));let c=i;const u=i+o;for(const[i,s]of r){const r=s*o*l,a=Math.max(4,Math.floor(r));if(a<4)continue;const h=e===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,u-c);if(d<4)break;this.drawLetter(i,t+1,c,n,d,h),c+=d}}drawColumnBorder(e,t,n,i){this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+1,t,n,i)}drawLetter(e,t,n,i,o,s=!1){if(!this.ctx)return;const r=this.getMonomerBackgroundColor(e),a=this.getMonomerTextColor(e);this.ctx.fillStyle=r,this.ctx.fillRect(t,n,i,o),s&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(t,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(t,n,i,o),this.drawLetterText(e,t,n,i,o,a)}drawLetterSeparators(e,t,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,t+i<t+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(e,t+i),this.ctx.lineTo(e+n,t+i),this.ctx.stroke())}drawLetterText(e,t,n,i,o,s){const r=Math.min(.8*o,.8*i);r>=7&&(this.ctx.fillStyle=s,this.ctx.font=`bold ${r}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,t+i/2,n+o/2))}getMonomerBackgroundColor(e){if(this.monomerLib)try{const t=this.monomerLib.getMonomerColors(this.biotype,e);if(t&&t.backgroundcolor)return t.backgroundcolor}catch(e){console.warn("Error getting background color from monomerLib:",e)}return"#CCCCCC"}getMonomerTextColor(e){const t=this.getMonomerBackgroundColor(e);try{const e=a.Color.fromHtml(t),n=a.Color.getContrastColor(e);return a.Color.toHtml(n)}catch(e){return console.warn("Error calculating contrast color:",e),"#000000"}}}class zi extends ji{constructor(e,t=Zi.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(t,Zi.MIN_TRACK_HEIGHT,i),this.data=e,this.colorScheme=n,this.visible=e.length>0}updateData(e){this.data=e,this.visible=e.length>0}draw(e,t,n,i,o,s,r,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/s);for(let n=0;n<l;n++){const l=o+n;if(l>r)break;const c=e+n*s,u=s,h=c+u/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,u,h,t,i),l===a&&(this.ctx.fillStyle=Wi,this.ctx.fillRect(c,t,u,i)))}}drawConservationBar(e,t,n,i,o,s){if(!this.ctx)return;const r=this.data[e];this.ctx.fillStyle=qi,this.ctx.fillRect(t+2,o,n-4,s);let a="#3CB173";if("default"===this.colorScheme)r<.5?a="#E74C3C":r<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=r<.2?"#E74C3C":r<.4?"#FF7F00":r<.6?"#FFFF00":r<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const e=Math.round(255*r);a=`rgb(255, ${e}, ${e})`}const l=r*s;this.ctx.fillStyle=a,this.ctx.fillRect(t+2,o+s-l,n-4,l),this.ctx.strokeStyle=Yi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+2,o,n-4,s),n>20&&(this.ctx.fillStyle=Ui,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*r)}%`,i,o+s/2))}}const Zi={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Xi={BASE:Zi.DOTTED_CELL_HEIGHT+Zi.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Zi.TITLE_HEIGHT+Zi.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP}};class Ji{constructor(e,t){this.gridColumn=t,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:e.x||0,y:e.y||0,width:e.width||0,height:e.height||0,windowStartPosition:e.windowStartPosition||1,positionWidth:e.positionWidth||15,totalPositions:e.totalPositions||5e3,headerHeight:e.headerHeight||Xi.BASE,sliderHeight:e.sliderHeight||Zi.SLIDER_HEIGHT,currentPosition:e.currentPosition||1,cellBackground:void 0===e.cellBackground||e.cellBackground,sliderColor:e.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:e.onPositionChange||((e,t)=>{}),onHeaderHeightChange:e.onHeaderHeightChange||(()=>{}),...e},this.eventElement=r.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const e=this.config.headerHeight,t=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach((e=>{e.setVisible(!1),e.setHeight(Zi.DEFAULT_TRACK_HEIGHT)})),!(e<Xi.WITH_TITLE()||e<Xi.WITH_WEBLOGO()))if(e<Xi.WITH_BOTH()){if(t){t.setVisible(!0);const n=e-Xi.WITH_WEBLOGO();t.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}}else{if(t&&t.setVisible(!0),n&&n.setVisible(!0),t&&e>Xi.WITH_BOTH()){const n=e-Xi.WITH_BOTH();t.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach(((e,t)=>{this.userSelectedTracks[t]||e.setVisible(!1)})),e<Xi.WITH_WEBLOGO()&&t&&t.setVisible(!1),e<Xi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const e=this.getTrack("conservation"),t=this.getTrack("weblogo"),n=e?.isVisible()??!1,i=t?.isVisible()??!1;let o=this.config.width-16;const s=this.config.headerHeight>=Xi.WITH_TITLE()?(Zi.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&e&&(o-=70,this.drawTrackButton("conservation","Conservation",o,s,70,14),o-=4),!i&&t&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,s,70,14)))}drawTrackButton(e,t,n,i,o,s,r=!1){this.ctx&&(this.trackButtons.push({id:e,label:t,x:n,y:i,width:o,height:s}),this.ctx.fillStyle=r?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,s),this.ctx.strokeStyle=r?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,s),this.ctx.fillStyle=r?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,n+o/2,i+s/2))}handleTrackButtonClick(e,t){for(const n of this.trackButtons)if(e>=n.x&&e<=n.x+n.width&&t>=n.y&&t<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(e,t){return t<(this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0)}snapToTrackHeight(e){let t;if("weblogo"===e)t=Xi.WITH_WEBLOGO();else{if("conservation"!==e)return;t=Xi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach(((e,t)=>{this.userSelectedTracks[t]=!1}))),"conservation"===e?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===e&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame((()=>this.redraw()))}resetToAutoMode(){this.userSelectedTracks=null;const e=this.tracks.size>0?Xi.WITH_BOTH():Xi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame((()=>this.redraw()))}drawColumnTitle(e,t,n,i){this.ctx&&i&&this.config.headerHeight>=Xi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(e,t,n,Zi.TITLE_HEIGHT),this.ctx.fillStyle=Ui,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,e+n/2,t+Zi.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach((e=>{e instanceof Ki&&e.setHovered(-1,null)})),window.requestAnimationFrame((()=>this.redraw())))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(e,t,n,i){this.dataFrame=e,this.seqColumn=t,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(e){if(!this.isValid)return;const{x:t,y:n}=this.getCoords(e),i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,l=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,c=l-Zi.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let u=null,h=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let g=c;for(const{id:e,track:t}of d){const i=g-t.getHeight();if(n>=i&&n<g){u=e,h=n-i;break}g=i-Zi.TRACK_GAP}let f=null;if(u){const e=this.tracks.get(u);e&&(f=e.getMonomerAt(t,h,s))}if((this.previousHoverPosition!==s||this.previousHoverTrack!==u||this.previousHoverMonomer!==f)&&(this.previousHoverPosition=s,this.previousHoverTrack=u,this.previousHoverMonomer=f,u)){const e=this.tracks.get(u);e instanceof Ki&&(e.setHovered(s,f),window.requestAnimationFrame((()=>this.redraw())))}if((s!==this.currentHoverPosition||u!==this.currentHoverTrack||f!==this.currentHoverMonomer)&&(this.currentHoverPosition=s,this.currentHoverTrack=u,this.currentHoverMonomer=f,u)){const t=this.tracks.get(u);if(t){const n=t.getTooltipContent(s,f);if(n)return void r.tooltip.show(n,e.clientX+16,e.clientY+16)}}u&&f||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame((()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,r.tooltip.hide()}draw(e,t,n,i,o,s,r,a){if(Object.assign(this.config,{x:e,y:t,width:n,height:i,currentPosition:o,windowStartPosition:s}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(e,t,n,i),this.ctx.translate(e,t),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Xi.WITH_TITLE();l&&Zi.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Zi.SLIDER_HEIGHT,u=c-Zi.DOTTED_CELL_HEIGHT,h=u-Zi.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const g=this.getTrack("conservation");g&&g.isVisible()&&p.push({id:"conservation",track:g});let f=h;for(const{track:e}of p){const t=e.getHeight(),i=f-t;e.draw(0,i,n,t,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:t}),f=i-Zi.TRACK_GAP}if(this.drawDottedCells(0,u,n,Zi.DOTTED_CELL_HEIGHT,c),d.push({y:u,height:Zi.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const e=this.config.positionWidth,t=this.config.currentPosition-this.config.windowStartPosition;if(t>=0&&t<Math.floor(n/e)){const n=t*e+e/2;for(let e=0;e<d.length-1;e++){const t=d[e],i=d[e+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,t.y+t.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),r.preventDefault(),this.setupEventElement()}drawDottedCells(e,t,n,i,o){if(!this.ctx)return;const s=this.config.totalPositions,r=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/r),u=t+Zi.TOP_PADDING;this.drawSlider(e,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>s)break;const h=e+n*r,d=r,p=h+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(h,t,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(h,t),this.ctx.lineTo(h,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,u+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Ui,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,u+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(h,t,d,i))}}drawSlider(e,t,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(e,t,n,Zi.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,s=this.config.totalPositions-i,r=this.sliderWidth,a=s<=0?0:(o-1)/s*(n-r),l=s<=0?n:r;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(e+a,t,l,Zi.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e+o-1,t-2,3,Zi.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(e){const t=this.canvas.getBoundingClientRect();return{x:e.clientX-t.left-this.config.x,y:e.clientY-t.top-this.config.y}}isInHeaderArea(e){const{x:t,y:n}=this.getCoords(e);return t>=0&&t<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(e){this.config.positionWidth=e}isInSliderArea(e){const{y:t}=this.getCoords(e),n=this.config.headerHeight-Zi.SLIDER_HEIGHT;return t>n&&t<n+Zi.SLIDER_HEIGHT}get sliderWidth(){const e=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(e,20)}isInSliderDraggableArea(e){const{x:t,y:n}=this.getCoords(e),i=this.config.headerHeight-Zi.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),s=this.config.windowStartPosition,r=this.config.totalPositions-o,a=r<=0?0:(s-1)/r*(this.config.width-this.sliderWidth);return n>i&&n<i+Zi.SLIDER_HEIGHT&&t>=a&&t<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",(e=>{this.isValid&&(this.isInSliderDraggableArea(e)?this.eventElement.style.cursor="grab":this.isInSliderArea(e)||this.isInHeaderArea(e)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")})),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(e){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return;if(this.isInsideColumnHeaderArea(t,n))return;const i=this.config.positionWidth,o=Math.floor(t/i),s=this.config.windowStartPosition+o-1;if(s<0||s>=this.config.totalPositions)return;const r=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,a=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,l=a-Zi.TRACK_GAP;if(n>=a||n<r)return;let c=null,u=0;const h=[],d=this.getTrack("weblogo");d&&d.isVisible()&&h.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&h.push({id:"conservation",track:p});let m=l;for(const{id:e,track:t}of h){const i=m-t.getHeight();if(n>=i&&n<m){c=e,u=n-i;break}m=i-Zi.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(t,u,s);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(s,i);this.selectRowsWithMonomerAtPosition(s,i),e.stopPropagation(),e.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(e,t){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(e,!0);n.init((e=>i[e]===t))}catch(e){console.error("Error selecting rows:",e)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const e=this.canvas.getContext("2d");e?(this.ctx=e,this.tracks.forEach((t=>t.init(e)))):console.error("Failed to get 2D context from canvas")}addTrack(e,t){this.ctx&&t.init(this.ctx),this.tracks.set(e,t)}removeTrack(e){this.tracks.delete(e)}getTrack(e){return this.tracks.get(e)}updateTrack(e,t){const n=this.getTrack(e);n&&t(n)}get isValid(){const e=this.gridColumn,t=e?.grid,n=t?.horzScroll?.min||0,i=t?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Xi.WITH_TITLE()&&t&&(Qi(e.left??0,n,i)||Qi(e.right??1/0,n,i))}handleMouseDown(e){if(!this.isValid)return;const{x:t}=this.getCoords(e);this.isInSliderDraggableArea(e)&&(this.state.isDragging=!0,this.state.dragStartX=t,this.handleSliderDrag(t),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation())}handleMouseWheel(e){if(this.isValid&&this.isInHeaderArea(e)){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t=e.shiftKey?Math.sign(e.deltaY):Math.sign(e.deltaX||e.deltaY),n=e.shiftKey?3:1,i=this.config.windowStartPosition+t*n,o=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(s,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(e){if(!this.state.isDragging||!this.isValid)return;const t=this.canvas.getBoundingClientRect(),n=e.clientX-t.left-this.config.x;this.handleSliderDrag(n),e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}handleKeyDown(e){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===e.key||"ArrowRight"===e.key){e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation();const t="ArrowLeft"===e.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+t,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=t<0?n:Math.max(1,n-i+1))}else{if("Escape"!==e.key)return;this.config.currentPosition=-2,e.preventDefault(),e.stopPropagation(),e.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(e){if(!this.isValid)return;const t=this.sliderWidth,n=this.config.width-t,i=Math.max(0,Math.min(this.config.width,e)),o=Math.floor(this.config.width/this.config.positionWidth),s=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-s,a=Math.max(0,i-t/2)/n*r;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(e){this.config.headerHeight=e}handleClick(e){if(!this.isValid)return;e.clientX,this.canvas.getBoundingClientRect().left,e.clientY,this.canvas.getBoundingClientRect().top;const{x:t,y:n}=this.getCoords(e);if(this.handleTrackButtonClick(t,n))return e.preventDefault(),void e.stopPropagation();if(!this.isInsideColumnHeaderArea(t,n)&&n<this.config.headerHeight-Zi.SLIDER_HEIGHT&&n>=0){const e=this.config.positionWidth,n=Math.round(t/e-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(e){Object.assign(this.config,e),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(e){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,e)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Xi.BASE,WITH_TITLE:Xi.WITH_TITLE(),WITH_WEBLOGO:Xi.WITH_WEBLOGO(),WITH_BOTH:Xi.WITH_BOTH()}}}function Qi(e,t,n){return e>=t&&e<=n}class eo{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){eo.conservationCache=new a.LruCache(100),eo.webLogoCache=new a.LruCache(100),eo.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return eo.lastInvalidationTime}static getChunkCacheKey(e,t,n){const i=e.dataFrame;return`${i.id}_${e.name}_f${i.filter.version}_${t}_${n}`}static getConservationChunk(e,t,n,i){return eo.conservationCache.getOrCreate(i,(()=>{const o=eo.getWebLogoChunk(e,t,n,i),s=new Array(n-t).fill(0);for(let i=t;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let r=0,a=0;const l=e.defaultGapOriginal;for(const[e,t]of n.entries())e&&e!==l&&(r+=t,t>a&&(a=t));s[i-t]=r>0?a/r:0}return s}))}static getWebLogoChunk(e,t,n,i){return eo.webLogoCache.getOrCreate(i,(()=>{const i=e.column.dataFrame,o=new Map,s=i.filter.trueCount;if(s<=1)return o;for(let e=t;e<n;e++)o.set(e,new Map);const r=i.filter,a=1/s;for(let i=-1;-1!==(i=r.findNext(i,!0));){const s=e.getSplitted(i).getOriginalRegion(t,n);if(0!==s.length)for(let e=0;e<s.length;e++){const n=s[e],i=o.get(t+e);i.set(n,(i.get(n)||0)+a)}}return o}))}static getConservationForViewport(e,t,n,i){const o=new Array(i).fill(0),s=Math.floor(t/eo.CHUNK_SIZE)*eo.CHUNK_SIZE,r=Math.ceil(n/eo.CHUNK_SIZE)*eo.CHUNK_SIZE;for(let t=s;t<r;t+=eo.CHUNK_SIZE){const n=Math.min(t+eo.CHUNK_SIZE,i),s=eo.getChunkCacheKey(e.column,t,n),r=eo.getConservationChunk(e,t,n,s);for(let e=0;e<r.length&&t+e<i;e++)o[t+e]=r[e]}return o}static getWebLogoForViewport(e,t,n,i){const o=new Map,s=Math.floor(t/eo.CHUNK_SIZE)*eo.CHUNK_SIZE,r=Math.ceil(n/eo.CHUNK_SIZE)*eo.CHUNK_SIZE;for(let t=s;t<r;t+=eo.CHUNK_SIZE){const n=Math.min(t+eo.CHUNK_SIZE,i),s=eo.getChunkCacheKey(e.column,t,n),r=eo.getWebLogoChunk(e,t,n,s);for(const[e,t]of r.entries())e<i&&o.set(e,t)}return o}}class to extends Ki{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=eo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),s=Math.min(this.maxLength,t+20),r=eo.getWebLogoForViewport(this.seqHandler,o,s,this.maxLength);this.updateData(r)}draw(e,t,n,i,o,s,r,a){const l=Math.ceil(n/s)+2,c=Math.min(o+l,r);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,s,r,a)}}class no extends zi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(e,t,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=e,this.maxLength=t,this.visible=e.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(e,t){const n=eo.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-e)>=10||Math.abs(this.lastViewportEnd-t)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=e,this.lastViewportEnd=t,this.lastInvalidationTime=n;const o=Math.max(0,e-20),s=Math.min(this.maxLength,t+20),r=eo.getConservationForViewport(this.seqHandler,o,s,this.maxLength);this.updateData(r)}draw(e,t,n,i,o,s,r,a){const l=Math.ceil(n/s)+2,c=Math.min(o+l,r);this.updateForViewport(o-1,c-1),super.draw(e,t,n,i,o,s,r,a)}}var io=function(e,t,n,i){var o,s=arguments.length,r=s<3?t:null===i?i=Object.getOwnPropertyDescriptor(t,n):i;if("object"==typeof Reflect&&"function"==typeof Reflect.decorate)r=Reflect.decorate(e,t,n,i);else for(var a=e.length-1;a>=0;a--)(o=e[a])&&(r=(s<3?o(r):s>3?o(t,n,r):o(t,n))||r);return s>3&&r&&Object.defineProperty(t,n,r),r},oo=function(e,t){if("object"==typeof Reflect&&"function"==typeof Reflect.metadata)return Reflect.metadata(e,t)},so=function(e,t){return function(n,i){t(n,i,e)}};const ro=new ai;let ao=null;class lo{static async getMonomerLibHelper(){return await dn.getInstance()}static async initBio(){null===ao&&(ao=async function(){const e="Bio: _package.initBio()";ro.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,Pe.j)(),i=await ro.getProperties(),o=new ri(i);ro.properties=o;const r=await dn.getInstance(),l=await(0,Ie.ub)();l.explicit&&(l.explicit=[],await(0,Ie.Eu)(l)),await r.awaitLoaded(1/0),r.initialLoadCompleted||await r.loadMonomerLib(),r.loadMonomerSets();const c=r.getMonomerLib(),h=r.getMonomerSets(),d=window.performance.now();ro.logger.debug(`${e}, loading ET: ${d-t} ms`);const p=new Bi(r,n);ro.completeInit(p,c,h,n),ro.logger.debug(`${e}, end`),function(){const e=e=>{setTimeout((()=>{if(e.isDetached)return;const t=e.dataFrame;if(!t)return;const n=t.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=ro.seqHelper.getSeqHandler(i)}catch(e){continue}if(!n)continue;if(n.isHelm()||n.alphabet===ge.YI.UN)continue;const o=e.col(i.name);if(!o)continue;let r=!!e.tableView&&Array.from(e.tableView.viewers).some((e=>"Sequence Position Statistics"===e.type));if(n.isMsa()){const l=(e,t)=>Number.isNaN(e)?t:e,c=()=>l(Math.max(Number.parseInt(i.getTag(ge.gp.positionShift)??"0"),0),0)+1,h=()=>l(Number.parseInt(i.getTag(ge.gp.selectedPosition)??"-2"),-2),d=()=>$e.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const g=i.categories;for(let e=0;e<g.length;e++){const t=g[e];t&&t.length>m&&(m=t.length,p=e)}const f=g[p],y=n.splitter(f),b=y?y.length:30,w={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let v;v=i.length>1e5||b<50?w.WITH_TITLE:i.length>5e4?w.WITH_WEBLOGO:w.WITH_BOTH;let A=null,C=null;const T=a.debounce(u.merge(t.onFilterChanged,t.onDataChanged.pipe((0,H.filter)((e=>e?.args?.column===i)))),100).subscribe((()=>{eo.clearAllCaches(),A&&(A.resetViewportTracking(),A.forceUpdate()),C&&(C.resetViewportTracking(),C.forceUpdate()),setTimeout((()=>{e.isDetached||e.invalidate()}),50)}));e.sub(T);const S=s=>{const l=[],u=new no(n,b,45,"default","Conservation");C=u,l.push({id:"conservation",track:u,priority:1});const p=new to(n,b,45,"WebLogo");A=p,s&&(p.setMonomerLib(s),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new Ji({canvas:e.overlay,headerHeight:v,totalPositions:b+1,onPositionChange:(t,n)=>{setTimeout((()=>{const o=c(),s=h();if(o!==n.start&&i.setTag(ge.gp.positionShift,(n.start-1).toString()),s!==t&&(i.setTag(ge.gp.selectedPosition,t.toString()),t>=0&&!r&&e.tableView&&R()(e.dataFrame?.columns.numerical).find((e=>!0)))){r=!0;const t=e.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});e.tableView.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))},onHeaderHeightChange:t=>{e.isDetached||t<w.WITH_TITLE||setTimeout((()=>e.props.colHeaderHeight=t))}},o);m.setupTooltipHandling(),l.forEach((({id:e,track:t})=>{m.addTrack(e,t)})),m.setSelectionData(t,i,n),b>50&&(e.props.colHeaderHeight=v,setTimeout((()=>{e.isDetached||(o.width=400)}),300)),e.sub(e.onCellRender.subscribe((e=>{const t=e.cell;if(!t||!t.isColHeader||t?.gridColumn?.name!==o?.name)return;const n=e.bounds;if(!n)return;m.headerHeight=n.height;const s=d();m.positionWidth=s+8;const r=c();m.draw(n.x,n.y,n.width,n.height,h(),r,e,i.name)})))};(0,ye.pj)().then((e=>{const t=e.getMonomerLib();S(t)})).catch((e=>{s.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",e)}))}}}),1e3)},t=(s.events.onViewerAdded.subscribe((t=>{if(!(t.args&&t.args.viewer instanceof a.Grid))return;const n=t.args.viewer;e(n)})),s.shell.tableViews);for(const n of t){const t=n?.grid;t&&e(t)}}()}()),await ao}static sequenceTooltip(e){const t=new hi(e,ro.seqHelper);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();s.shell.error(t)})),t}static getBioLib(){return ro.monomerLib}static getSeqHandler(e){return ro.seqHelper.getSeqHandler(e)}static getRegionPanel(e){const t="getRegionTopMenu",n=a.Func.find({package:ro.name,name:t});if(1!==n.length)throw new Error(`Package '${ro.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new gi(i,ro.seqHelper).widget()}static async libraryPanel(e){return async function(){const e=r.label("Manage monomer libraries");return mn()(e).addClass("d4-link-action"),e.onclick=async()=>await Bn(),new a.Widget(e)}()}static GetRegionEditor(e){try{new gi(e,ro.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;s.shell.error(`Get region editor error: ${t}`),ro.logger.error(t,void 0,n)}}static SplitToMonomersEditor(e){const t=new ei;r.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}static SequenceSpaceEditor(e){const t=new O({semtype:a.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}static SeqActivityCliffsEditor(e){const t=new Ce({semtype:a.SEMTYPE.MACROMOLECULE}),n=r.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}static customSequenceCellRenderer(){return new je}static fastaSequenceCellRenderer(){return new je}static separatorSequenceCellRenderer(){return new je}static macroMolColumnPropertyPanel(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=ro.properties?ro.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=r.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=De.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=ro.properties?ro.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(o=e.temp[".mm.cellRenderer.fontSize"]);const s=r.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=De.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=r.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=De.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=r.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),u=r.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),h=r.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;(()=>{const t=e.meta.units;return t!==ge.Hi.HELM&&t!==ge.Hi.CUSTOM})()&&(d=r.input.bool("Multiline Rendering",{value:"true"===e.getTag("renderMultiline"),onValueChanged:t=>{e.tags.renderMultiline=t?"true":"false",e.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[s,i,l,u,c,h];d&&p.push(d);const m=r.inputs(p);return new a.Widget(m)}(e)}static compositionAnalysisWidget(e){return function(e,t,n){const i=r.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=e.cell.column.tags[ge.gp.alphabet],s=o===ge.YI.DNA||o===ge.YI.RNA?Fe.o.NUCLEOTIDE:Fe.o.AA,l={},c=n.getSeqHandler(e.cell.column),u=e.cell.rowIndex,h=c.getSplitted(u);R().count(0).take(h.length).filter((e=>!h.isGap(e))).forEach((e=>{let t=h.getCanonical(e);s===Fe.o.NUCLEOTIDE&&c.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=l[t]||0;l[t]=n+1}));const d=(0,ui.F)(l,s,t);return Array.from(d.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),i.appendChild(d),new a.Widget(i)}(e,ro.monomerLib,ro.seqHelper)}static macromoleculeDifferenceCellRenderer(){return new ze}static sequenceAlignment(e,t,n,i,o){const s=new ht(i,o,n,t);return"Local alignment"==e?s.smithWaterman():s.needlemanWunsch()}static webLogoViewer(){return new it.oP}static vdRegionsViewer(){return new lt}static getRegion(e,t,n,i){return di(e,t??null,n??null,i??null)}static async getRegionTopMenu(e,t,n,i,o){const r=di(t,n??null,i??null,o??null);t.dataFrame.columns.add(r),await s.data.detectSemanticTypes(t.dataFrame)}static async activityCliffs(e,t,n,i,o,u,h,d,p){if(e.name!==s.shell.tv.dataFrame.name)return void s.shell.error(`Table ${e.name} is not a current table view`);if(!(0,Zn.V)(t,"Activity Cliffs"))return;const m=Me(e),g={units:t.meta.units,aligned:t.getTag(ge.gp.aligned),separator:t.getTag(ge.gp.separator),alphabet:t.getTag(ge.gp.alphabet)},f=u,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,f,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,g,h,mt,gt,wt,void 0,p),w=o===c.c.UMAP?2e5:2e4,v=o===c.c.UMAP?5e3:2e3;if(e.rowCount>w)return void s.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${w}`);const A=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),C=await new Promise(((t,n)=>{e.rowCount>v&&!d?.[l.vb]?r.dialog().add(r.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():b().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,ve.AP)(e);throw ro.logger.error(t,void 0,n),e})).finally((()=>{A.close()}));return C?.props?.xColumnName&&C?.props?.yColumnName&&e.col(C.props.xColumnName)&&e.col(C.props.yColumnName)&&(e.col(C.props.xColumnName).set(0,e.col(C.props.xColumnName).get(0)),e.col(C.props.yColumnName).set(0,e.col(C.props.yColumnName).get(0))),C}static async macromoleculePreprocessingFunction(e,t,n=1,i=.6,o="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:s,options:r}=await dt(e,t,o,n,i);return{entries:s,options:r}}static async helmPreprocessingFunction(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,pt.BQ)(e,ro.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await s.functions.call("Chem:getMorganFingerprints",{molColumn:n}),o=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);o[e]=W.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:o,options:{}}}static async sequenceSpaceTopMenu(e,t,n,i,o,r,c,u,h){if(e.name!==s.shell.tv.dataFrame.name)return void s.shell.error(`Table ${e.name} is not a current table view`);const d=s.shell.tv.dataFrame==e?s.shell.tv:void 0;return(0,Zn.V)(t,"Sequence Space")?(r||(r=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),c??={},await Le(e,[t],n,[i],[1],[r],"MANHATTAN",o,u??!1,{...c,preprocessingFuncArgs:[c.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:c?.[l.vb],tableView:d})):void 0}static async toAtomicLevel(e,t,n,i=!1){const o=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await ao;const o=t.temp[".mm.cellRenderer.overriddenLibrary"]??ro.monomerLib,s=ro.seqHelper,r=ro.rdKitModule;await(0,fi.V)(e,t,n,i,o,s,r)}finally{o.close()}}static async toAtomicLevelAction(e){if(!e?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const t=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!t)throw new Error("To Atomic level Function not found");t.prepare({table:e.dataFrame,seqCol:e}).edit()}static async toAtomicLevelPanel(e){return async function(e){const t=await Vi(e);if(t.errorText||!t.mol)return a.Widget.fromRoot(r.divText(t.errorText??"No structure generated"));try{const e=a.SemanticValue.fromValueType(t.mol,a.SEMTYPE.MOLECULE),n=r.panels.infoPanel(e);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=s.chem.drawMolecule(t.mol,300,300,!1);return o.style.cursor="pointer",r.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const e=window.innerWidth-200,n=window.innerHeight-200,i=s.chem.drawMolecule(t.mol,e,n,!1);r.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(e){ro.logger.error(e)}return a.Widget.fromRoot(r.divText("No structure generated"))}(e)}static async sequence3dStructureWidget(e){return async function(e){const t=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Vi(e);if(o.errorText||!o.mol)return n=r.divText(o.errorText??"No structure generated"),t.close(),new a.Widget(n);const l=o.mol;i=await s.functions.call("Bio:Embed",{molecule:l});const c=vi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(e){console.warn(e)}try{i=i.replaceAll("\\n","\n");const e=new Blob([i],{type:"text/plain"}),t=r.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});t.style.setProperty("height","100%","important");const o=new NGL.Stage(t,{backgroundColor:"white"});o.loadFile(e,{ext:"sdf"}).then((function(e){o.setSize(300,300),e.addRepresentation("ball+stick"),e.autoView()})),n=r.div([t],{style:{aspectRatio:"1"}})}catch(e){n=r.divText("Couldn't get 3D structure")}}catch(e){n=r.divText("Couldn't get 3D structure")}return t.close(),new a.Widget(n)}(e)}static multipleSequenceAlignmentDialog(){(0,Jn.D)({},ro.seqHelper).catch((e=>{const[t,n]=(0,ve.AP)(e);if(e instanceof Xn.Ap)return s.shell.warning(e.element),void ro.logger.warning(t);s.shell.error(t),ro.logger.error(t,void 0,n)}))}static async alignSequences(e=null,t=null,n){return(0,Jn.D)({col:e,clustersCol:t,...n},ro.seqHelper)}static async compositionAnalysis(){const e=s.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(ro.seqHelper.getSeqHandler(e),!0))),n=async t=>{if(!(0,Zn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});s.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>ro.seqHelper.getSeqHandler(e).isMsa())),o=r.input.choice("Column",{value:i?i.name:e[0],items:e});r.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(r.div([o])).onOK((async()=>{const e=t.find((e=>e.name==o.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else s.shell.error("Current table does not contain sequences")}static importFasta(e){return new fe.m(e).importFasta()}static importBam(e){return console.log(e),[]}static convertDialog(){const e=(0,Ne.me)()[0];(0,Mt.C)(e,ro.seqHelper)}static convertColumnAction(e){(0,Mt.C)(e,ro.seqHelper)}static monomerCellRenderer(){return new oi}static async testDetectMacromolecule(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await s.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const o=[];for(const r of n)try{const t=await s.dapi.files.readAsText(e+r.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await s.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&o.push({file:r.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){o.push({file:r.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${r.fileName}`)}s.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const r=a.DataFrame.fromObjects(o);return r.name=`datasets_detectMacromolecule_${e}`,r}static async splitToMonomersTopMenu(e,t){return await async function(e,t){if(await(0,Qe.cb)(10),!(0,Zn.V)(t,"Sequence space"))return e;const n=ro.seqHelper,i=(0,be.R)(t,n);i.name="splitToMonomers";const o=t.dataFrame;for(const e of i.columns)e.semType=Ve.uF.MONOMER,e.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const r=/(\d+)(?: \((\d+)\))?/,l=e=>{r.lastIndex=0;const t=e.match(r);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=Ve.uF.MONOMER,n.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const s=100;let r=0;for(;o.columns.byName(n.name)&&r<s;)n.name=l(n.name),r++;o.columns.add(n)}await s.data.detectSemanticTypes(o);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return o}(e,t)}static getHelmMonomers(e){return ro.seqHelper.getSeqMonomers(e)}static similaritySearchViewer(){return new Tt(ro.seqHelper)}static similaritySearchTopMenu(){const e=s.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}static diversitySearchViewer(){return new St(ro.seqHelper)}static diversitySearchTopMenu(){const e=s.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}static searchSubsequenceEditor(e){const t=(0,Ne.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new pt.a7(t,ro.seqHelper)}static SubsequenceSearchTopMenu(e){s.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),s.shell.tv.grid.scrollToCell(e,0)}static async sequenceIdentityScoring(e,t,n){const i=ro.seqHelper;return yi(e,t,n,pe.IDENTITY,i)}static async sequenceSimilarityScoring(e,t,n){const i=ro.seqHelper;return yi(e,t,n,pe.SIMILARITY,i)}static async manageMonomerLibraries(){Bn()}static async manageLibrariesView(){await Vn()}static async manageMonomersView(){const e=await Mn.getInstance();await e.getViewRoot()}static async manageMonomerLibrariesView(){return await Vn(!1)}static async manageMonomerLibrariesViewTreeBrowser(e,t){(await(await dn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe((async()=>{const e=await Mn.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()}))}))}static saveAsFasta(){(0,xt.TE)()}static bioSubstructureFilter(){return new Lt._i(ro.seqHelper,ro.logger)}static bioSubstructureFilterTest(){return new Lt._i(ro.seqHelper,ro.logger)}static async webLogoLargeApp(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Qn(e,"webLogoLargeApp"),n=await ro.files.readCsv("data/sample_PT_100000x5.csv");await s.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async webLogoAggApp(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Qn(e,"webLogoAggApp"),n=await ro.files.readCsv("samples/FASTA_PT_activity.csv");await s.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}static async getRegionApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new mi(e,"getRegionApp");await t.init()}finally{e.close()}}static async getRegionHelmApp(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await ro.files.readCsv("samples/HELM_empty_vals.csv"),n=new mi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}static longSeqTableSeparator(){const e=a.DataFrame.fromColumns((0,_e.dW)());s.shell.addTableView(e)}static longSeqTableFasta(){const e=a.DataFrame.fromColumns([(0,_e.Hx)(ro.seqHelper,ge.Hi.FASTA)]);s.shell.addTableView(e)}static longSeqTableHelm(){const e=a.DataFrame.fromColumns([(0,_e.Hx)(ro.seqHelper,ge.Hi.HELM)]);s.shell.addTableView(e)}static addCopyMenu(e,t){!function(e,t,n){const i=Object.values(ge.Hi).filter((e=>e!==ge.Hi.CUSTOM));t.group("Copy").items(i,(t=>{const i=e.column,o=e.rowIndex,r=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?ro.properties.defaultSeparator??"-":void 0,l=r.getJoiner({notation:t,separator:a})(r.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),s.shell.info(`Value of notation '${t}' copied to clipboard`)):s.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t,ro.seqHelper)}static async demoBioSimilarityDiversity(){await async function(){const e=await ro.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=s.shell.addTableView(e);await e.meta.detectSemanticTypes(),await s.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Ne.Kd)(t.grid,"sequence",500,30);const o=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),s.functions.call("Dendrogram:HierarchicalClustering",{df:s.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}static async demoBioSequenceSpace(){await async function(){const e=await s.functions.eval("Bio:SeqSpaceDemo"),t=await s.dapi.projects.find(e.id);await t.open(),s.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}static async demoBioActivityCliffs(){await async function(){const e=await ro.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await s.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=s.shell.addTableView(e);r.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await lo.activityCliffs(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,me.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),mn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const o=Array.from(t.viewers).find((e=>e!==t.grid&&e.type===a.VIEWER.GRID));o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,t.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;s.shell.error(t),ro.logger.error(e.message,void 0,n)}(e)}finally{r.setUpdateIndicator(t.root,!1)}s.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}static async demoBioAtomicLevel(){await async function(){const e=await ro.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await s.data.detectSemanticTypes(e);const t=s.shell.addTableView(e),n=e.col("HELM");await lo.toAtomicLevel(e,n,!0,!1),(0,Ne.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Ne.Kd)(t.grid,"HELM",500,void 0,!0),s.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),s.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}static async sdfToJsonLib(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}static async seq2atomic(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),o=await s.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const r=(await lo.getMonomerLibHelper()).getMonomerLib(),l=ro.seqHelper,c=await(0,Pe.j)(),u=(await(0,fi.V)(i,n,t,!1,r,l,c))?.molCol?.get(0);return u??void 0}catch(e){const[t,n]=(0,ve.AP)(e);throw ro.logger.error(t,void 0,n),e}}static async seqIdentity(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await s.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await yi(i,n,t,pe.IDENTITY,ro.seqHelper)).get(0)}catch(e){const[t,n]=(0,ve.AP)(e);throw ro.logger.error(t,void 0,n),e}}static async detectMacromoleculeProbe(e,t="",n=100){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const r=await s.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await s.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${r.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Qe.cb)(0))}l>0?s.shell.warning(`detectMacromolecule failed ${l} / ${n}`):s.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}static async getSeqHelper(){return await lo.initBio(),ro.seqHelper}static async getMolFromHelm(e,t,n=!0){return async function(e,t,n=!0,i){const o=ro.seqHelper,s=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,ro.rdKitModule,i);return s.semType=a.SEMTYPE.MOLECULE,s}(0,t,n,ro.monomerLib)}}io([s.decorators.func({description:"Returns an instance of the monomer library 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strict";n.d(t,{a7:()=>m,if:()=>f,BQ:()=>y,nI:()=>g});var i=n(4328),o=n(7389),s=n(6082),r=n(8070),a=n(2003),l=n(439);const c=31;async function u(e,t,n=!1,o){const r=t.getSeqHandler(e);let a;o??=new Map;const l=r.isHelm()?t.getSeqMonomers(e):Object.keys(r.stats.freq).filter((e=>""!==e));for(let e=0;e<l.length;e++)o.has(l[e])||o.set(l[e],`${o.size+1}`);if(r.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:e}),a=function(e,t,n=!1){const i=new Array(e.length);for(let o=0;o<e.length;o++){let s=0,r=0,a="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const l=e.get(o);s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1;const u=parseInt(l.substring(s,s+3)),h=parseInt(l.substring(s+3,s+6));a+=`M  V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M  V30 BEGIN ATOM\n";for(let e=0;e<u;e++){s=l.indexOf("\n",s)+1+c,r=l.indexOf(" ",s);const i=l.substring(s,r);a+=n?`M  V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${e+1} At 0.000 0.000 0 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${t+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}var d=n(4870);const p="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,d.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(p,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,d.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===s.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=s.DataFrame.create(1);t.columns.addNewString(p).init((e=>"")),t.col(p).semType=this.col.semType,t.col(p).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===a.Hi.HELM?t.get(p,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await f(n,this.col,this.seqHelper):g(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function g(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,o=e.charAt(e.length-1)===t,s=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${s}${n}`:`${n}${s}${n}|${n}${s}$`:o?`^${s}${n}|${n}${s}${n}`:`^${s}${n}|${n}${s}${n}|${n}${s}$`}(e,n):e,o=s.BitSet.create(t.length);for(let n=0;n<t.length;n++){const s=t.get(n);(s.match(i)||s===e)&&o.set(n,!0,!1)}return o}async function f(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await y(t,n,!0);const o=s.Column.string("helm",1).init((t=>e));o.semType=s.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const r=await u(o,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:r.get(0),molBlockFailover:""})).get(0)}async function y(e,t,n){const i=s.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,r.cb)(10);const i=new Map,o=await u(e,t,n,i);e.temp["monomeric-mols"]=o,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>r,l:()=>a});var i=n(4328),o=n(6082),s=n(8926);function r(e,t,n=[],o=[],r=!0){const l=s._package.seqHelper,[c,u]=a(e,t,l,n,o);return r&&!c&&i.shell.warning(u),c}function a(e,t,n,s=[],r=[]){let a=!0,l="";if(e.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),o=i.notation;if(s.length>0&&!s.some((e=>o.toUpperCase()==e.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;r.length>0&&!r.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==r.length?"any alphabet":`alphabet${r.length>1?"s":""} ${r.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>h,J:()=>c,b9:()=>u,gN:()=>a,uF:()=>s});var i,o,s,r=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean 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d(n,t,e,i)})).show({x:350,y:100}),u.push(c.onClose.subscribe((e=>{u.forEach((e=>{e.unsubscribe()})),u=[],c=null}))))}async function d(e,t,n,i){const o=t.getSeqHandler(e).convert(n,i);e.dataFrame.columns.add(o);const r=await s.functions.call("Bio:detectMacromolecule",{col:o});return r&&(o.semType=r),await s.data.detectSemanticTypes(e.dataFrame),o}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>s,pk:()=>o,xe:()=>i});const i="|",o="$",s="H"},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>a});var i=n(6956);class o{constructor(e){const t=e.split(i.xe).filter((e=>e));t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const o=i[t],s=e.split(":"),r={monomerIdx:parseInt(s[0])-1,rGroupId:parseInt(s[1].slice(1))};n.push({polymerId:o,bond:r})})),e.push(n)})),e}}var s=n(8438);class r{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach((e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter((e=>!!e)).map((e=>(0,s.D)(e)));n.push(...t),t.forEach(((e,t)=>i.push(t%3==1?"Branch":"Backbone")))}else n.push((0,s.D)(e)),i.push("Backbone")})),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],o=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:o,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],o=i-1;e.push([{monomerIdx:o,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class a{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(i.pk),n=t[0].split(i.xe);this.simplePolymers=n.map((e=>new r(e))),this.connectionList=new o(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map((e=>e.monomers.length)).reduce(((e,t)=>e+t),0),t=Array.from({length:e},(()=>[]));return this.bondData.forEach((e=>{e.forEach((e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)}))})),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),o=e[n.id];this.shiftBondMonomerIds(o,i),t.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],o=t.bond;o.monomerIdx+=n,i.push(o)})),t.push(i)})),t}}},8604:(e,t,n)=>{"use strict";n.d(t,{Es:()=>o,G3:()=>r,VV:()=>a,gt:()=>s,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",o="System:AppData/Bio/monomer-sets/",s="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",r={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}},a={PEPTIDE:326,RNA:383,CHEM:0}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>x});var i=n(4328),o=n(6082),s=n(7389),r=n(8070),a=n(2003),l=n(608),c=n(8152),u=n(966),h=n(4139),d=n(5072),p=n.n(d),m=n(7825),g=n.n(m),f=n(7659),y=n.n(f),b=n(5056),w=n.n(b),v=n(540),A=n.n(v),C=n(1113),T=n.n(C),S=n(6369),E={};E.styleTagTransform=T(),E.setAttributes=w(),E.insert=y().bind(null,"head"),E.domAPI=g(),E.insertStyleElement=A(),p()(S.A,E),S.A&&S.A.locals&&S.A.locals;var M=n(8926);async function x(e,t){return new Promise((async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const u=e.col?.dataFrame??i.shell.t;if(!u){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(s.divText(e)))}const d=e.col??u.columns.bySemType(o.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return void a(new l.Ap(s.divText(e)))}const p=s.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=s.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const g=s.p(`Kalign version: ${h.b9}`,"kalign-version"),f=s.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const y=s.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=s.input.bool("Selected Rows Only",{value:!1}),w=s.inputs([f,y,m]),v=s.button("Alignment parameters",(()=>{w.hidden=!w.hidden,[f,y,m].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");v.classList.add("msa-params-button"),w.hidden=!0,v.prepend(s.icons.settings((()=>null)));const 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e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function D(e,t,n=!1,i="",s=null,r,c,u,h){let d=t.toList();n&&(d=d.map((e=>R.clean(e).replace(/\-/g,""))));const p=t.length;s??=o.Column.string("Clusters",p).init("0"),s.type!=o.COLUMN_TYPE.STRING&&(s=s.convertTo(o.TYPE.STRING)),s.compact();const m=s.categories,g=s.getRawData(),f=new Array(m.length),y=new Array(m.length);if(h){const t=e.selection;if(0===t.length)throw new Error("No selected rows in the table.");for(let e=-1;-1!==(e=t.findNext(e,!0));){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}}else for(let e=0;e<p;++e){const t=g[e];(f[t]??=[]).push(d[e]),(y[t]??=[]).push(e)}B(y,m);const b=await new I(["base/1.0.0",{tool:"kalign",version:$.b9,reinit:!0}]),w=o.Column.string(i,p);for(let e=0;e<m.length;++e){const t=f[e];if(!t||0===t.length)continue;const n=F(t);await b.fs.writeFile(O,n);const i=`${void 0!==r?` --gpo ${r}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==u?` --tgpe ${u}`:""}`,o=await b.exec(`kalign ${O} -f fasta -o ${H}${i}`);console.warn(o);const s=await b.cat(H);if(!s){const e=G(o,1);throw new Error(e)}const l=new a.m(s).sequencesArray,h=y[e];for(let e=0;e<l.length;++e)w.set(h[e],l[e])}const v=t.meta.units,A=t.getTag(l.gp.alphabet);return w.meta.units=v,w.setTag(l.gp.aligned,"SEQ.MSA"),w.setTag(l.gp.alphabet,A),w.semType=o.SEMTYPE.MACROMOLECULE,w}function G(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(e))&&(void 0===t||n.length<t);)n.push(o[1]);return n.join("\n")}function B(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...r()(n).take(3).map((e=>{let o=t[e];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new k(e)}}},8152:(e,t,n)=>{"use strict";n.d(t,{GD:()=>d,ZY:()=>u});var i=n(4328),o=n(6082),s=n(2003),r=n(608),a=n(4139),l=n(8926);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n,i="ginsi",l=1.53,u=0,d=null,m,g=!1){const f=await c.getDockerContainer(),y=t.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,w=d.getRawData(),v=new Array(b.length),A=new Array(b.length);if(g){const n=e.selection;for(let e=-1;-1!==(e=n.findNext(e,!0));){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(A[n]??=[]).push(e))}}else for(let e=0;e<y;++e){const n=w[e];if(!b[n])continue;const i=n,o=t.get(e);o&&((v[i]??=[]).push({ID:e.toString(),HELM:o}),(A[n]??=[]).push(e))}(0,r.aZ)(A,b);const C=new Array(y).fill(null);for(const e of v){if(!e||0===e.length)continue;const t=(await p(f.id,e,i,l,u,m)).Alignment;for(const e of t)C[parseInt(e.ID)]=Object.entries(e).filter((e=>!h.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.J.SEPARATOR)}const T=o.Column.fromStrings(n,C);return T.meta.units=s.Hi.SEPARATOR,T.setTag(s.gp.separator,a.J.SEPARATOR),T.setTag(s.gp.aligned,"SEQ.MSA"),T.setTag(s.gp.alphabet,s.YI.UN),T.setTag(s.gp.alphabetIsMultichar,"true"),T.semType=o.SEMTYPE.MACROMOLECULE,T}async function p(e,t,n,o,s,r){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${o}&gap_extend=${s}`,u=window.performance.now(),h=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-u} ms`);const p="application/json"===h.headers.get("content-type");if(!h.ok&&p){const e=await h.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const n=e["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(h.statusText)}if(!h.ok&&!p){const e=await h.text();throw new Error(`Error: ${e}`)}if(!p){const e=await h.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}const m=await h.json();if("pepsea-stderr"in m){const e=m["pepsea-stderr"];r?.warning(e)}return m}},3890:(e,t,n)=>{"use strict";n.d(t,{TE:()=>u,aS:()=>d,wz:()=>h});var i=n(6082),o=n(7389),s=n(4328),r=n(1991),a=n.n(r),l=n(8926);const c=60;function u(){const e=s.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),r=n?[n.name]:[],u=o.input.multiChoice("Seq id columns",{value:r,items:t.map((e=>e.name))}),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const 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v,A,C=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new s.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},s.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class T{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new T),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?s.Column.fromFloat32Array(n,e):e instanceof Int32Array?s.Column.fromInt32Array(n,e):s.Column.fromList(s.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===d.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===d.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,o,r,a,l,c){const u=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let h=c*l+(n-u-1);const p=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1));for(const[n,i]of p){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new s.Rect((e-t)*l*r,h,a*l,n),h+=n}}render(e,t,n,i,o,s,r){for(const[a,l]of Object.entries(this._freqs))if(a!==f._S){const c=(0,h.zS)(a,r),u=l.bounds,d=u.left;let p=y.S$;s&&(p=s.getMonomerTextColor(o,a)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(d,u.top,u.width,u.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(c);e.setTransform(u.width/m.width,0,0,u.height/i,d,u.top),e.fillText(c,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,C.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(v||(v={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.maxMonomerLetters="maxMonomerLetters",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(A||(A={}));const E=d.Fo;var M;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(M||(M={}));const x=new class{render=20};class L extends s.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(A.sequenceColumnName,E.sequenceColumnName,{category:v.DATA,semType:s.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const e=[s.AGG.KEY,s.AGG.PIVOT,s.AGG.MISSING_VALUE_COUNT,s.AGG.SKEW,s.AGG.KURT,s.AGG.SELECTED_ROWS_COUNT],t=Object.values(s.AGG).filter((t=>!e.includes(t)));this.valueColumnName=this.string(A.valueColumnName,E.valueColumnName,{category:v.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(A.valueAggrType,E.valueAggrType,{category:v.DATA,choices:t,description:"Aggregation method for value column"}),this.startPositionName=this.string(A.startPositionName,E.startPositionName,{category:v.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(A.endPositionName,E.endPositionName,{category:v.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(A.skipEmptySequences,E.skipEmptySequences,{category:v.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(A.skipEmptyPositions,E.skipEmptyPositions,{category:v.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(A.shrinkEmptyTail,E.shrinkEmptyTail,{category:v.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(A.backgroundColor,E.backgroundColor,{category:v.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(A.positionHeight,E.positionHeight,{category:v.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(A.positionWidth,E.positionWidth,{category:v.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(A.verticalAlignment,E.verticalAlignment,{category:v.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(A.horizontalAlignment,E.horizontalAlignment,{category:v.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(A.fixWidth,E.fixWidth,{category:v.LAYOUT,userEditable:!1}),this.fitArea=this.bool(A.fitArea,E.fitArea,{category:v.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(A.minHeight,E.minHeight,{category:v.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(A.maxHeight,E.maxHeight,{category:v.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(A.maxMonomerLetters,E.maxMonomerLetters,{category:v.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(A.showPositionLabels,E.showPositionLabels,{category:v.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(A.positionMarginState,E.positionMarginState,{category:v.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(A.positionMargin,n,{category:v.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(A.filterSource,E.filterSource,{category:v.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",b.PackageFunctions.getMonomerLibHelper().then((e=>{this.monomerLib=e.getMonomerLib(),this.render(M.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(M.Render,"monomerLib changed")})))})),this.viewSyncer=new g.g(b._package.logger)}static viewerCounter=-1;viewerId=++L.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;b._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),b._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(s.debounce(this.renderRequest,x.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(M.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(M.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(A.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,h.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(M.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;let t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t);this.fitArea&&t<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/t),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,t=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,t));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=t>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=i*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,o=this.root.clientHeight/n,s=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*s,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const r=(this._positionWidth+this.positionMarginValue)*this.Length,a=s*n,l=Math.min(this.root.clientWidth,r);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=r>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),e,t)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}safeUpdateSlider(e,t,n,i){w(e,this.slider.minRange,.1)&&w(t,this.slider.maxRange,.1)&&w(n,this.slider.min,.1)&&w(i,this.slider.max,.1)||this.slider.setValues(e,t,n,i)}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case A.sequenceColumnName:this.updateSeqCol();break;case A.sequenceColumnName:case A.startPositionName:case A.endPositionName:case A.filterSource:case A.shrinkEmptyTail:case A.skipEmptyPositions:case A.positionHeight:case A.valueColumnName:case A.valueAggrType:this.render(M.Freqs,`onPropertyChanged( ${e.name} )`);break;case A.minHeight:case A.maxHeight:case A.maxMonomerLetters:case A.positionWidth:case A.showPositionLabels:case A.fixWidth:case A.fitArea:case A.horizontalAlignment:case A.verticalAlignment:case A.positionMargin:case A.positionMarginState:this.render(M.Layout,`onPropertyChanged(${e.name})`);break;case A.backgroundColor:this.render(M.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;b._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),b._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const s=o.getMonomerAt(n,e.y);return void 0===s?[o,null,null]:[o,s,o.getFreq(s)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=M.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=M.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(h.gp.positionNames),t=this.seqCol.getTag(h.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(h.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(h.z1).map((e=>e.trim())):[...Array(o).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(h.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const r=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<r;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<r;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?f._S:i,s=this.positions[e],r=s.getFreq(o);++s.sumRowCount,r.value=++r.rowCount}if(this.valueAggrType===s.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),o=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,s=this.seqHandler.defaultGapOriginal===o?f._S:o,r=t.get(n);this.positions[e].getFreq(s).push(r)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===s.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<r;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),r=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=M.Layout&&((e,t,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const r=this.canvas.height-o*n;let a;if(this.valueAggrType===s.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,r,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,r,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=s.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,o,s,r,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(r);t<=Math.floor(a);t++){const n=s[t],i=e.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(r);l<=Math.floor(a);l++){const a=s[l],h=(l-r)*n*t+i*t/2,d=(o*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,u=this.seqHandler.defaultBiotype;for(let e=o;e<=r;e++)this.positions[e].render(a,i,l,c,u,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=M.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):b._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const t=e.max-e.min,n=this.canvas.offsetWidth/t-this.positionMarginValue;w(n,this.positionWidth,.1)?this.render(M.Layout,"sliderOnValuesChanged"):this.getProperty(A.positionWidth)?.set(this,n)}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(M.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(M.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[r,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==r&&null===a&&0<=i.y&&i.y<=l){const e=[o.divText(`Position ${r.label}`)];if(this.valueAggrType===s.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(r.buildCompositionTable(t,this.monomerLib))}const t=o.divV(e);t.style.maxHeight="80vh",o.tooltip.show(t,n.x+16,n.y+16)}else if(null!==r&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=r.getFreq(a),t=[o.div(`${a}`),o.div(`${e.rowCount} rows`)];this.valueAggrType!==s.AGG.TOTAL_COUNT&&t.push(o.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=o.divV(t);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,o,s){const r=t.getSplitted(i),a=s.pos<r.length?r.getCanonical(s.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),e,o,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=p(e);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(M.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function _(e,t,n,i,o){let s=0,r=-1;for(;-1!=(r=n.findNext(r,!0));){const e=t.getSplitted(r),n=o.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===i&&s++}return s}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>S,AR:()=>T});var i=n(7389),o=n(6082),s=n(4328),r=n(1991),a=n.n(r),l=n(1858),c=n(2003),u=n(8070),h=n(7602),d=n(4954),p=n(4574),m=n(1757),g=n.n(m),f=n(9124),y=n(9192),b=n(4870),w=n(8926);class v extends p.O{seqHelper;emptyProps=new p.n("",void 0,w._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,f.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,w._package.logger)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class C{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,o){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class T extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class S extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger)}static filterCounter=-1;filterId=++S.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(A,new C(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,w._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e,void 0,w._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends p.O{emptyProps=new T("",void 0,w._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator,w._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||"";this.props=new T(this.props.substructure,t,w._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("",void 0,w._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},9713:e=>{"use strict";e.exports=rxjs.operators},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:o,removeDotSegments:s,recomposeAuthority:r,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const o={};return 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n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=r(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=s(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),o.push(e)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const 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0===s.fragment?s.reference="absolute":s.reference="uri":s.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==s.reference&&(s.error=s.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||s.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&s.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(s.host))try{s.host=URL.domainToASCII(s.host.toLowerCase())}catch(e){s.error=s.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(r&&void 0!==s.scheme&&(s.scheme=unescape(s.scheme)),r&&void 0!==s.host&&(s.host=unescape(s.host)),s.path&&(s.path=escape(unescape(s.path))),s.fragment&&(s.fragment=encodeURI(decodeURIComponent(s.fragment)))),e&&e.parse&&e.parse(s,n)}else s.error=s.error||"URI can not be parsed.";return s}const m={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(p(e,i),p(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function o(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function s(e){const t="https"===String(e.scheme).toLowerCase();return 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b("seq\nFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP","seq\nFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHP\nYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP")})),(0,t.t6)("isCorrectHelm",(async()=>{await i("seq\n  PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2}$$$$\n  PEPTIDE1{meI.Aca.N.T.dE.Thr_PO3H2}$$$$\n  PEPTIDE1{hHis.Aca.N.T.dE.Thr_PO3H2}$$$$","seq\n  meI.hHis.Aca.N.T.dE.Thr_PO3H2\n  .meI.Aca.N.T.dE.Thr_PO3H2\n  .hHis.Aca.N.T.dE.Thr_PO3H2",l.Hi.HELM,l.Hi.SEPARATOR,void 0,"mafft")}),{timeout:8e4,skipReason:"Fails in docker"}),(0,t.t6)("isCorrectHelmLong",(async()=>{await i("seq\n  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M-M-E-L-V-L-K-T-I-I-G-P-I-V-V-G-V-V-L-R-I-V-D-K-W-L-N-K-D-K\n  M-D-R-T-D-E-V-S-N-H-T-H-D-K-P-T-L-T-W-F-E-E-I-F-E-E-Y-H-S-P-F-H-N","seq\n  MIEV-FLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n  MMEL-VLKTII-GPIVVGVVLRIVDKWLNKDK------\n  MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN-----",l.Hi.SEPARATOR,l.Hi.FASTA,l.YI.PT)}))}));var w=n(1991),v=n.n(w),A=n(7278),C=n(6718),T=n(6642);async function S(t){const n=await async function(e){return await Ce.files.readAsText(e)}(t),i=e.DataFrame.fromCsv(n);return i.name=t.replace(".csv",""),i}async function E(e,n=5e3){await(0,t.cb)(0),await(0,t.PE)(e.onAfterDrawContent,(()=>{}),(()=>{e.invalidate()}),n);const i=e.columns.length;for(let t=0;t<i;++t){const n=e.columns.byIndex(t);if(n){const t=e.cell(n.name,0),[i,r,a]=(0,T.BG)(t),l=(void 0,(s=o=a.rendererBack)&&void 0!==s.onRendered&&void 0!==s.invalidate&&void 0!==s.awaitRendered?o:null);l&&await l.awaitRendered()}}var o,s}var M=n(4139),x=n(4356);async function L(e,n){const i=(0,l.J9)(e);console.debug(`Bio: tests: splitters: 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e=["M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",["M","MeI","Y","K","E","T","L","L","MeF","P","K","T","D","F","P","M","R","G","G","L","MeA"]],n=["[meI][Pip][dK][Thr_PO3H2][L-hArg(Et,Et)][D-Tyr_Et][Tyr_ab-dehydroMe][dV]EN[D-Orn][D-aThr][Phe_4Me]",["meI","Pip","dK","Thr_PO3H2","L-hArg(Et,Et)","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],i=["PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],o=["PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.D-Dap.dV.E.N.pnG.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],s=["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[D-Dap].[dV].E.N.[pnG].[Phe_4Me]}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],r=["RNA1{R(U)P.R(T)P.R(G)P.R(C)P.R(A)}$$$$",["R(U)P","R(T)P","R(G)P","R(C)P","R(A)"]],a=["RNA1{P.R(U)P.R(T)}$$$$",["P","R(U)P","R(T)"]],l=["RNA1{P.R(U).P.R(T)}$$$$",["P","R(U)","P","R(T)"]];(0,t.t6)("fastaMulti",(async()=>{await 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a.data.detectSemanticTypes(o);const s=a.shell.addTableView(o);await E(s.grid),(0,t.E3)(s.grid.dataFrame.id,e.id)})),(0,t.t6)("getHelmMonomers",(async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await a.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],i=t.getCol("HELM"),o=await a.functions.call("Bio:getHelmMonomers",{sequence:i}),s=n.filter((e=>!o.includes(e))),r=o.filter((e=>!n.includes(e)));if(s.length>0||r.length){const e=[];throw s.length>0&&e.push(`Missed monomers ${JSON.stringify(s)}.`),r.length>0&&e.push(`Unexpected monomers ${JSON.stringify(r)}.`),new Error(e.join(" "))}}))}));var I=n(8604);(0,t.L1)("monomerLibraries",(()=>{let e,n=null;(0,t.gM)((async()=>{e=await(0,C.pj)(),n=(0,x.ub)()})),(0,t.Pl)((async()=>{await(0,x.Eu)(n)})),(0,t.t6)("default",(async()=>{await(0,x.Eu)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadMonomerLib(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await e.loadMonomerLibForTests(),function(e,n){const i=n,o=e.getSummaryObj();for(const e in i)i[e]||delete i[e];for(const e in o)o[e]||delete o[e];if(0==Object.keys(i).length&&0!=Object.keys(o).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(i).length&&0==Object.keys(o).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(o,i),(0,t.Xk)(i,o)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(i)} does not match actual ${JSON.stringify(o)}.`)}}(e.getMonomerLib(),I.VV)})),(0,t.t6)("empty",(async()=>{const n=await(0,x.ub)(),i=await e.getFileManager();let o=i.getValidLibraryPaths();0===o.length&&(o=await i.getValidLibraryPathsAsynchronously()),n.exclude=o,n.explicit=[],await(0,x.Eu)(n),await e.loadMonomerLib(!0);const s=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===s.length,!0)})),(0,t.t6)("override",(async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},i=e.getMonomerLib(),o=i.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null===o,!0,`Unexpectedly found monomer '${n.symbol}' `);const s=i.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);s&&(s.lib=void 0),(0,t.Xk)(s,n)}))}));var P=n(7389),N=n(1757),R=n.n(N),$=n(1858),O=n(6873),H=n(5433);async function k(n,i){const o=n(),s=e.DataFrame.fromColumns(o);await a.data.detectSemanticTypes(s);const r=Date.now(),l=(s.columns.byName("MSA"),a.shell.addTableView(s));await E(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id);const c=Date.now()-r;console.log(`Performance test: ${i}: ${c}ms`)}(0,t.L1)("renderers",(()=>{let n;(0,t.gM)((async()=>{n=await(0,c.Q)()})),(0,t.t6)("long sequence performance 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E(r.grid),(0,t.E3)(r.grid.dataFrame.id,i.id);const l=o.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(l,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=M.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]),o=a.shell.addTableView(i);await a.data.detectSemanticTypes(i),await E(o.grid),(0,t.E3)(o.grid.dataFrame.id,i.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,M.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const i=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),o=(await a.functions.call("Bio:importFasta",{fileContent:i}))[0],s=o.getCol("sequence"),r=await a.functions.call("Bio:detectMacromolecule",{col:s});r&&(s.semType=r);const c=a.shell.addTableView(o);await a.data.detectSemanticTypes(o),console.log("Bio: tests/renderers/afterMsa, table view"),await E(c.grid),(0,t.E3)(c.grid.dataFrame.id,o.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${s.semType}", units="${s.meta.units}", cell.renderer="${s.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(s.meta.units,l.Hi.FASTA),(0,t.E3)(s.getTag(l.gp.aligned),"SEQ"),(0,t.E3)(s.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,y.D)({col:s},n);await E(c.grid),(0,t.E3)(c.grid.dataFrame.id,o.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,l.Hi.FASTA),(0,t.E3)(u.getTag(l.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const i=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),o=e.DataFrame.fromCsv(i),s=o.getCol("sequence"),r=await a.functions.call("Bio:detectMacromolecule",{col:s});r&&(s.semType=r);const c=a.shell.addTableView(o);await a.data.detectSemanticTypes(o);const u=await(0,H.r)(s,n,l.Hi.SEPARATOR,"/");await E(c.grid),(0,t.E3)(c.grid.dataFrame.id,o.id);const h=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(h,"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const i=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),o=a.shell.addTableView(i);await E(o.grid),await i.meta.detectSemanticTypes(),await a.data.detectSemanticTypes(i);const s=i.getCol("sequence"),r=n.getSeqHandler(s).convert(l.Hi.HELM);i.columns.add(r),await E(o.grid),(0,t.E3)(r.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=M.uF.MACROMOLECULE_DIFFERENCE;const i=e.DataFrame.fromColumns([n]);a.shell.addTableView(i),await(0,t.cb)(100);const o=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==o)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${o}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const n=e.DataFrame.fromCsv(i);n.currentRowIdx=0;const o=a.shell.addTableView(n);await n.meta.detectSemanticTypes(),await a.data.detectSemanticTypes(n);const s=n.plot.scatter({x:"x",y:"y"});o.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),E(o.grid,500)]);const r=s.root.getBoundingClientRect(),l=s.worldToScreen(1,0),c=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:r.left+l.x,clientY:r.top+l.y}),u=R()(s.root).find("canvas").get()[0];await(0,t.PE)(e.debounce((0,$.fromEvent)(u,"mousemove"),200),(()=>{Ce.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(R()(P.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(l.x,l.y),1)}),(()=>{u.dispatchEvent(c)}),500),await E(o.grid,500)}()}),{skipReason:"GROK-17450"});const i="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var F=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,i;(0,t.gM)((async()=>{n=await(0,C.pj)(),i=await(0,x.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,x.Eu)(i),await n.loadMonomerLib(!0)}));const o={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:190},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,i]of Object.entries(o))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(i.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),o=new F.Jy(null,n,Ce.logger,3,(()=>({font:"12px monospace",fontCharWidth:7,separatorWidth:12,monomerToShort:l.zS})));await o.init();const s=i.testList;for(let e=0;e<n.length;++e)o.getCellMonomerLengths(e,1e4);const r=[];for(const[e,t]of v().enumerate(s)){const t={pos:o.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&r.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(r.length>0)throw new Error("Test failed error(s):\n"+r.join(", \n"))}));const s=[10,20,30,40,50,60],r={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(r))(0,t.t6)("hitBounds-"+e,(async()=>{const e=(0,F.Bb)(s,n.x);(0,t.E3)(e,n.tgt)}));const c={mono1:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6/m7/m8/m9\nn1/m2/n3/m4/n5/m6/n7/m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGaps:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5/n6/m7/n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,187,213,239]}},monoWithGapColumn:{src:{csv:"seq\nm1/m2/m3/m4/m5/m6//m8/m9\nn1/m2/n3/m4/n5/m6//m8/n9\nm1/n2/m3/n4/m5///n8/m9\n"},tgt:{lengths:[5,31,57,83,109,135,161,180,206,232]}}};for(const[n,i]of Object.entries(c))(0,t.t6)(`getCellMonomerLengths-${n}`,(async()=>{const n=e.DataFrame.fromCsv(i.src.csv);await a.data.detectSemanticTypes(n);const o=n.getCol("seq"),s=new F.Jy(null,o,Ce.logger,3,(()=>({fontCharWidth:7,font:"12px monospace",separatorWidth:12,monomerToShort:l.zS})));await s.init();const r=s.getCellMonomerLengths(0,1e3)[1];(0,t.J6)(r,i.tgt.lengths)}))})),(0,t.L1)("converters",(()=>{let n,i;(0,t.gM)((async()=>{n=await(0,c.Q)()})),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(i||(i={}));const o={[i.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[i.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[i.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[i.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[i.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[i.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[i.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[i.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[i.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[i.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[i.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[i.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[i.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[i.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[i.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[i.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[i.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[i.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},s=new Set(Object.values(l.gp));async function r(t){const n=o[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i}function u(e,i){if(e===l.Hi.SEPARATOR&&!i)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(o){const s=n.getSeqHandler(o).convert(e,i);return(0,t.E3)(s.meta.units,e),s}}async function h(e,i,o){const a=(await r(e)).getCol("seq"),c=i(a),u=(await r(o)).getCol("seq");(0,t.J6)(c.toList(),u.toList());const h=n.getSeqHandler(a),d=n.getSeqHandler(c);for(const[e,n]of Object.entries(u.tags)){if(!s.has(e)||h.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e)||d.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e))continue;const i=c.getTag(e);(0,t.E3)(i,n,`Tag '${e}' expected value '${n}' is not equal to actual '${i}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await h(i.fastaPt,u(l.Hi.SEPARATOR,"-"),i.separatorPt)})),(0,t.t6)("testFastaDnaToSeparator",(async()=>{await h(i.fastaDna,u(l.Hi.SEPARATOR,"/"),i.separatorDna)})),(0,t.t6)("testFastaRnaToSeparator",(async()=>{await h(i.fastaRna,u(l.Hi.SEPARATOR,"*"),i.separatorRna)})),(0,t.t6)("testFastaGapsToSeparator",(async()=>{await h(i.fastaGaps,u(l.Hi.SEPARATOR,"/"),i.separatorGaps)})),(0,t.t6)("testFastaUnToSeparator",(async()=>{await h(i.fastaUn,u(l.Hi.SEPARATOR,"-"),i.separatorUn)})),(0,t.t6)("testFastaPtToHelm",(async()=>{await h(i.fastaPt,u(l.Hi.HELM),i.helmPt)})),(0,t.t6)("testFastaDnaToHelm",(async()=>{await h(i.fastaDna,u(l.Hi.HELM),i.helmDna)})),(0,t.t6)("testFastaRnaToHelm",(async()=>{await h(i.fastaRna,u(l.Hi.HELM),i.helmRna)})),(0,t.t6)("testFastaGapsToHelm",(async()=>{await h(i.fastaGaps,u(l.Hi.HELM),i.helmGaps)})),(0,t.t6)("testSeparatorPtToFasta",(async()=>{await h(i.separatorPt,u(l.Hi.FASTA),i.fastaPt)})),(0,t.t6)("testSeparatorDnaToFasta",(async()=>{await 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created",100);(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.scores.get(0),e.FLOAT_NULL),(0,t.E3)(c.idxs.get(0),0),(0,t.E3)(c.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(c.scores.get(1).toFixed(2),"0.10"),(0,t.E3)(c.idxs.get(1),7),(0,t.E3)(c.molCol.get(1),"/D-Tyr_Et/meQ/dV/E/N/dV///Phe_4Me"),o.dataFrame.currentRowIdx=1,await(0,t.bk)((()=>1===c.targetMoleculeIdx),"Target molecule has not been changed",5e3),await(0,t.bk)((()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===c.molCol.get(0)),"Incorrect first similar molecule",5e3)}()})),(0,t.t6)("diversitySearchViewer",(async()=>{await async function(){const n=await Ce.files.readAsText("tests/sample_MSA_data.csv"),i=e.DataFrame.fromCsv(n),o=a.shell.addTableView(i);await a.data.detectSemanticTypes(i);const s=o.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const r=await o.dataFrame.plot.fromType("Sequence Diversity Search");let l=!1;if(r.computeCompleted.subscribe((e=>{e&&(l=!0)})),o.dockManager.dock(r,e.DOCK_TYPE.DOWN,null,"Diversity"),await r.renderPromise,await(0,t.bk)((()=>void 0!==K(o,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!r.initialized)throw new Error("The viewer is not initialized.");if(!r.targetColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!r.beforeRender())throw new Error("The viewer is not able to render.");if(!r.computeRequested)throw new Error("The viewer has not compute requested even.");if(!l)throw new Error("The viewer has not compute completed.");const c=r;await(0,t.bk)((()=>0!==c.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(c.fingerprint,"Morgan"),(0,t.E3)(c.distanceMetric,"Hamming"),(0,t.E3)(c.initialized,!0),(0,t.E3)(c.renderMolIds.length>0,!0)}()}))}));var z=n(1687),Z=n(4574);(0,t.L1)("bio-substructure-filters",(async()=>{let n,i,o;async function s(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. 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r=s.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{r.props=new Z.n(o,void 0,Ce.logger)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(r.props.substructure,o),(0,t.E3)(r.substructureInput.value,o),R()(s.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await E(i.grid),(0,t.E3)(r.props.substructure,""),(0,t.E3)(r.substructureInput.value,"")})),(0,t.t6)("reopen",(async()=>{const n=await Ce.files.readCsv("tests/filter_FASTA.csv"),i=a.shell.addTableView(n);await a.data.detectSemanticTypes(n),await n.meta.detectSemanticTypes();const o=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await E(i.grid),s.close(),await E(i.grid);const r=await n.plot.fromType(e.VIEWER.FILTERS,{filters:o});i.dockManager.dock(r,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await E(i.grid)}),{})}));var X=n(8152);class J{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var Q=n(9192);(0,t.L1)("PepSeA",(()=>{(0,t.t6)("Basic alignment",(async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),i=await(0,X.GD)(n,n.getCol("HELM"),"msa(HELM)"),o=n.getCol("MSA");for(let e=0;e<i.length;++e)(0,t.E3)(i.get(e)==o.get(e),!0)}),{timeout:6e4,stressTest:!0,skipReason:"Fails in docker"}),(0,t.t6)("stderr",(async()=>{const n=new 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m={[d.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[d.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[d.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[d.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[d.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[d.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[d.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[d.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[d.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async 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u,h;(0,t.gM)((async()=>{u=await(0,C.pj)(),h=await(0,x.ub)(),await u.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,x.Eu)(h),await u.loadMonomerLib(!0)})),(0,t.t6)("Identity",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:s,macromolecule:r,reference:c});for(let n=0;n<e.length;n++){const i=e.get(n),r=s.get(o,n);(0,t.Wj)(i,r,.01,`Wrong identity score for sequence at position ${n}`)}})),(0,t.t6)("Identity-shortReference",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:s,macromolecule:r,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$"});(0,t.E3)(v().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Identity-longReference",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:s,macromolecule:r,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$"});(0,t.E3)(v().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Similarity",(async()=>{const e=await a.functions.call("Bio:sequenceSimilarityScoring",{table:s,macromolecule:r,reference:c});for(let n=0;n<e.length;n++){const o=e.get(n),r=s.get(i,n);(0,t.Wj)(o,r,.01,`Wrong similarity score for sequence at position ${n}`)}}))}));const Ce=new e.Package;async function Te(n,i,o,s){const r=await(0,t.N$)({category:n,test:i,testContext:o,stressTest:s});return e.DataFrame.fromObjects(r)}async function Se(){await(0,t.Xb)(Ce,Ce.getModule("package-test.js"))}})(),bio_test=i})();
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