@datagrok/bio 2.22.3 → 2.22.5

package/dist/package.js

@@ -1,8 +1,8 @@
-var bio;(()=>{var t={8924:(t,e,n)=>{"use strict";var i=n(7362);class o extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,o)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,o)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new o({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in o.aaSynonyms?o.aaSynonyms[t]:t;return super.get(e)}}o.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return o.GrokGroups;case"lesk":return o.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const o of t)"("==o?e++:")"==o?e--:e?n+=o:i+=o;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){const n=this.getPalette(e);let[i,o]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,o=o.length>6?`${o.slice(0,3)}...`:o,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in n?[n.get(e),e,o,1]:[this.undefinedColor,i,o,1]}if("d"==t[0]&&t[1]in n&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in n?[n.get(e),e,o,2]:[this.undefinedColor,i,o,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in n?[n.get(e),e,o,3]:[this.undefinedColor,i,o,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in n?[n.get(e),e,o,4]:[this.undefinedColor,i,o,4]}return[this.undefinedColor,i,o,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(t,e,n)=>{"use strict";n.d(e,{j:()=>o});var i=n(6082);async function o(){const t=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===t.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await t[0].prepare().call()).getOutputParamValue()}},3599:(t,e,n)=>{"use strict";n.d(e,{o:()=>i.o});var i=n(6869)},9124:(t,e,n)=>{"use strict";n.d(e,{b2:()=>r,fA:()=>s});var i=n(7389),o=n(6082);async function r(){const t="Helm",e=o.Func.find({package:t,name:"getHelmHelper"});if(0===e.length)throw new Error(`Package '${t}' must be installed for HelmHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}function s(t,e){if(!t)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const o=t;return"ATOM"===o.T?(n=o.biotype(),i=o.elem):(n=t,i=e),[n,i]}o.JsInputBase,Error,i.input.helmAsync=async function(t,e){return(await r()).createHelmInput(t,e)}},8438:(t,e,n)=>{"use strict";function i(t){return t.startsWith("[")&&t.endsWith("]")?t.slice(1,-1):t}n.d(e,{D:()=>i})},8123:(t,e,n)=>{"use strict";n.d(e,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(t,e,n)=>{"use strict";n.d(e,{Eu:()=>a,ub:()=>s});var i=n(4328);const o="Libraries";let r=Promise.resolve();async function s(){let t;return r=r.then((async()=>{const e=i.userSettings.getValue(o,"Settings",!0);t=e?JSON.parse(e):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},t.exclude=t.exclude instanceof Array?t.exclude:[],t.explicit=t.explicit instanceof Array?t.explicit:[],t.duplicateMonomerPreferences=t.duplicateMonomerPreferences instanceof Object?t.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await r,t}async function a(t){r=r.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),i.userSettings.add(o,"Settings",JSON.stringify(t),!0)})),await r}},5553:(t,e,n)=>{"use strict";n.d(e,{Qc:()=>A,WN:()=>S});var i=n(1991),o=n.n(i);const r="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(t,e,n,i)=>{"function"==typeof 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C={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},A={sugar:v,phosphate:w,seqLength:t.length,atomCount:c,bondCount:u},S=new o.Cg,x=[];let E=0;for(C.i=0;C.i<A.seqLength;++C.i){const n=t[C.i];if(n.symbol===s._S)continue;const i=(0,o.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),r=C.nodeShift,l=C.bondShift;b(i,g,y,C,A),i.stereoAtoms?.forEach((t=>x.push(t+E))),E+=i.atoms.x.length;const c=C.nodeShift-r,h=new Array(c);for(let t=0;t<c;++t)h[t]=r+t;const u=C.bondShift-l,d=new Array(u);for(let t=0;t<u;++t)d[t]=l+t;S.set(C.i,{biotype:n.biotype,symbol:n.symbol,atoms:h,bonds:d})}p&&function(t,e,n,o){const r=n.nodeShift+1;t[o.atomCount]=i.u.V3K_BEGIN_DATA_LINE+r+" "+i.u.OXYGEN+" "+f(n.backbonePositionShift[0])+" "+n.flipFactor*f(n.backbonePositionShift[1])+" 0.000000 0\n";const s=n.backboneAttachNode,a=r;e[o.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+s+" "+a+"\n"}(g,y,C,A);const M=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+u+i.u.V3K_COUNTS_LINE_ENDING;let T="";return T+=i.u.V3K_HEADER_FIRST_LINE,T+=i.u.V3K_HEADER_SECOND_LINE,T+=i.u.V3K_BEGIN_CTAB_BLOCK,T+=M,T+=i.u.V3K_BEGIN_ATOM_BLOCK,T+=g.join(""),T+=i.u.V3K_END_ATOM_BLOCK,T+=i.u.V3K_BEGIN_BOND_BLOCK,T+=y.join(""),T+=i.u.V3K_END_BOND_BLOCK,x.length>0&&(T+=function(t){const e=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${t.length}`;for(let i=0;i<t.length;i++){const o=`${n} ${t[i]}`;o.length>76?(e.push(`${n} -\n`),n=`M  V30 ${t[i]}`):n=o,i===t.length-1&&e.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${e.join("")}M  V30 END COLLECTION\n`}(x)),T+=i.u.V3K_END_CTAB_BLOCK,T+=i.u.V3K_END,{molfile:T,monomers:S}}function h(t,e,n,i){i.flipFactor=(-1)**(i.i%2),u(t,e,n,i)}function u(t,e,n,o){!function(t,e,n){for(let o=0;o<t.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;e[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.atoms.atomTypes[o]+" "+f(n.backbonePositionShift[0]+t.atoms.x[o])+" "+f(n.backbonePositionShift[1]+n.flipFactor*t.atoms.y[o])+" "+t.atoms.kwargs[o]}}(t,e,o),p(t,n,o),function(t,e,n){if(0!==n.backboneAttachNode){const o=n.bondShift,r=n.backboneAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}}(t,n,o),null!==t.meta.branchShift&&t.meta.terminalNodes.length>2&&function(t,e){e.branchAttachNode=e.nodeShift+t.meta.terminalNodes[2];for(let n=0;n<2;++n)e.branchPositionShift[n]=e.backbonePositionShift[n]+t.meta.branchShift[n]}(t,o),function(t,e){e.backboneAttachNode=e.nodeShift+t.meta.terminalNodes[1],e.bondShift+=t.bonds.atomPairs.length+1,e.nodeShift+=t.atoms.atomTypes.length,e.backbonePositionShift[0]+=t.meta.backboneShift?.[0]??0,e.backbonePositionShift[1]+=e.flipFactor*(t.meta.backboneShift?.[1]??0)}(t,o)}function d(t,e,n,o,r){if(0===o.i)u(r.sugar,e,n,o);else for(const t of[r.phosphate,r.sugar])u(t,e,n,o);!function(t,e,n,o){(function(t,e,n){for(let o=0;o<t.atoms.atomTypes.length;++o){const r=n.nodeShift+o+1;e[n.nodeShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.atoms.atomTypes[o]+" "+f(n.branchPositionShift[0]+t.atoms.x[o])+" "+f(n.branchPositionShift[1]+n.flipFactor*t.atoms.y[o])+" "+t.atoms.kwargs[o]}})(t,e,o),p(t,n,o),function(t,e,n){const o=n.bondShift,r=n.branchAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+r+" "+s+"\n"}(t,n,o);const r=o.bondShift,s=o.branchAttachNode,a=t.meta.terminalNodes[0]+o.nodeShift;n[r-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+s+" "+a+"\n",o.bondShift+=t.bonds.atomPairs.length+1,o.nodeShift+=t.atoms.atomTypes.length}(t,e,n,o)}function p(t,e,n){for(let o=0;o<t.bonds.atomPairs.length;++o){const r=n.bondShift+o+1,s=t.bonds.atomPairs[o][0]+n.nodeShift,a=t.bonds.atomPairs[o][1]+n.nodeShift;let l="";if(t.bonds.bondConfiguration.has(o)){let e=t.bonds.bondConfiguration.get(o);n.flipFactor<0&&(e=1===e?3:1),l=" CFG="+e}const c=t.bonds.kwargs.has(o)?" "+t.bonds.kwargs.get(o):"";e[n.bondShift+o]=i.u.V3K_BEGIN_DATA_LINE+r+" "+t.bonds.bondTypes[o]+" "+s+" "+a+l+c+"\n"}}function m(t,e,n,r){let l=0,c=0,h=0,u=!0,d=null;for(const n of t)if(n.symbol!==s._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,o.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,h++}if("PEPTIDE"===r)l+=1,c+=h,h>0&&(d?.meta?.rNodes?.length??0)<2&&(u=!1,l-=1,c-=1);else{const r=n===s.YI.DNA?(0,o.xb)(e,i.u.DEOXYRIBOSE):(0,o.xb)(e,i.u.RIBOSE),a=(0,o.xb)(e,i.u.PHOSPHATE);l+=(t.length-1)*a.atoms.x.length,l+=t.length*r.atoms.x.length,l+=1,c+=(t.length-1)*a.bonds.bondTypes.length,c+=t.length*r.bonds.bondTypes.length,c-=1,c+=3*t.length}return{atomCount:l,bondCount:c,needsCapping:u}}function f(t){return Math.round(i.u.PRECISION_FACTOR*t)/i.u.PRECISION_FACTOR}},6077:(t,e,n)=>{"use strict";n.d(e,{C4:()=>m,eM:()=>f});var i=n(4328),o=n(6082),r=n(1991),s=n.n(r),a=n(439),l=n(3561),c=n(9235),h=n(294),u=n(9192),d=n(330),p=n(8123);async function m(t,e,n,r,l){if(e.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let h=e;const p=r.getSeqHandler(e);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=e.name);try{g=r.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(t){const[e,n]=(0,u.AP)(t);return{molCol:null,warnings:[e]}}const y=function(t,e){const n=t.length,o=new Array(n),r=e.getSeqHandler(t);let a=!1;const l=r.defaultBiotype;for(let t=0;t<n;++t){const e=r.getSplitted(t);a||(a=0===e.length),o[t]=s().count(0).take(e.length).filter((t=>!e.isGap(t))).map((t=>({position:t,biotype:l,symbol:e.getCanonical(t)}))).toArray()}return a&&i.shell.warning(`Some values in the "${t.name}" column are empty`),o}(h,r),b=f(y,m,g,n,l),v=h.length,w=await(0,c.R)(h,b,g,m,n,r,l);return w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`),w}function f(t,e,n,i,o){const r=(0,l.Hb)(i,e,n),s={},c={value:null};if("RNA"===e){const t=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of t)g(s,n.symbol,r,o,e,c)}for(let n=0;n<t.length;++n){const i=t[n];for(const t of i){const n=t.symbol;if(""!==n)try{if("RNA"===e&&3===n.split(/\(|\)/).filter((t=>!!t)).length){const t=n.split(/\(|\)/)[1];g(s,t,r,o,e,c),s[e]?.[t]&&(s[e][n]=s[e][t])}else g(s,n,r,o,e,c)}catch(t){const e=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${e}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${e}`)}}}return s}function g(t,e,n,i,o,r){const s={polymerType:o,symbol:e};if(!(0,h.bq)(t,s)){const a=function(t,e,n,i,o){if(e.has(t)){const 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e=t.atoms.x,n=t.atoms.y,i=t.meta.rNodes[2]-1,o=t.meta.terminalNodes[2]-1,r=e[i]-e[o],s=n[i]-n[o];return Math.atan2(r,s)}(t),o=t.meta.terminalNodes[0]-1,M(t,-n[o],-i[o])}(v,o):t===p.u.PHOSPHATE.symbol?function(t){const e=t.meta.rNodes[1]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,o=t.atoms.y;M(t,-i[e],-o[e]);const r=A(i[n],o[n]);S(t.atoms,Math.PI/2-r)}(v):function(t,e){const n=t.atoms.x,i=t.atoms.y,o=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;M(t,-n[o],-i[o]);const s=A(n[r],i[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(t.atoms,Math.PI-s+a);const c=function(t,e){return(0,l.YN)(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:n[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:n[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=c)for(let t=0;t<n.length;++t)n[t]=(0,l.YN)(n[t]/c),i[t]=(0,l.YN)(i[t]/c)}(v,o),function(t,e,n){"PEPTIDE"===t?(b(e,t),w(e,e.meta.rNodes[1])):n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),b(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],M(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),b(e,t),w(e,e.meta.rNodes[1]))}(i,v,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===p.u.HYDROGEN&&(w(t,e+1),--e),++e}(v),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)"oh"===t.atoms.atomTypes[e]?.toLowerCase()&&(t.atoms.atomTypes[e]="O"),"?"===t.atoms.atomTypes[e]&&(t.atoms.atomTypes[e]="H"),++e}(v),function(t){const e=" RGROUPS=(1 1)";for(let n=0;n<(t.atoms.kwargs?.length??0);n++){const i=t.atoms.kwargs[n];i&&i.includes(e)&&(t.atoms.kwargs[n]=i.replace(e,""))}}(v),v}var r;return null}(e,n,i,o,r);if(!a)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);(0,h.LQ)(t,s,a)}}function y(t,e){const n=e.rNodes;e.terminalNodes=new Array(n.length).fill(0);const i=e.terminalNodes,o=t.atomPairs;let r=0,s=0;for(;r<o.length&&s<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)o[r][e]===n[t]&&(i[t]=o[r][(e+1)%2],n.length,++s);++r}}function b(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=v(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=v(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function v(t,e,n){return[(0,l.YN)(t.atoms.x[e]-t.atoms.x[n]),(0,l.YN)(t.atoms.y[e]-t.atoms.y[n])]}function w(t,e){if(void 0!==e){const n=e-1,i=t.atoms,o=t.bonds,r=t.meta;i.atomTypes.splice(n,1),i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let t=0;t<r.terminalNodes.length;++t)r.terminalNodes[t]>e?--r.terminalNodes[t]:r.terminalNodes[t]===e&&(r.terminalNodes[t]=-1);for(let t=0;t<r.rNodes.length;++t)r.rNodes[t]>e?--r.rNodes[t]:r.rNodes[t]===e&&(r.rNodes[t]=-1);let s=0;for(;s<o.atomPairs.length;){const t=o.atomPairs[s][0],n=o.atomPairs[s][1];t===e||n===e?(o.atomPairs.splice(s,1),o.bondTypes=C(Uint32Array,o.bondTypes,s,1),o.bondConfiguration.has(s)&&o.bondConfiguration.delete(s),o.kwargs.has(s)&&o.kwargs.delete(s),--s):(o.atomPairs[s][0]=t>e?t-1:t,o.atomPairs[s][1]=n>e?n-1:n),++s}let a=Array.from(o.bondConfiguration.keys());a.forEach((t=>{if(o.bondConfiguration.has(t)&&t>n){const e=o.bondConfiguration.get(t);o.bondConfiguration.delete(t),o.bondConfiguration.set(t-1,e)}})),a=Array.from(o.kwargs.keys()),a.forEach((t=>{if(o.kwargs.has(t)&&t>n){const e=o.kwargs.get(t);o.kwargs.delete(t),o.kwargs.set(t-1,e)}}))}}function C(t,e,n,i){const o=new t(e.length-i);let r=0,s=0;for(;r<e.length;)r===n&&(r+=i),o[s]=e[r],++s,++r;return o}function A(t,e){let n;if(0===t)n=e>0?0:Math.PI;else if(0===e)n=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,o=Math.atan(i);n=t<0?Math.PI/2+o:-Math.PI/2+o}return n}function S(t,e){if(0!==e){const n=t.x,i=t.y,o=Math.cos(e),r=Math.sin(e);for(let t=0;t<n.length;++t){const e=n[t];n[t]=(0,l.YN)(e*o-i[t]*r),i[t]=(0,l.YN)(e*r+i[t]*o)}}}function x(t){E(t,!1)}function E(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const n=t.bonds.bondConfiguration;for(const[t,e]of n){const i=1===e?3:1;n.set(t,i)}}function M(t,e,n){const i=t.atoms.x,o=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=(0,l.YN)(i[t]+e),void 0!==n&&(o[t]=(0,l.YN)(o[t]+n))}},294:(t,e,n)=>{"use strict";function i(t,e){return t[e.polymerType]?.[e.symbol]}function o(t,e){return!!t[e.polymerType]?.[e.symbol]}function r(t,e,n){let i=t[e.polymerType];i||(i=t[e.polymerType]={}),i[e.symbol]=n}n.d(e,{Cg:()=>s,LQ:()=>r,bq:()=>o,vF:()=>a,xb:()=>i});class s extends Map{constructor(t){super(t)}}class a{constructor(t,e){this.molfile=t,this.monomers=e}static createEmpty(){return new a("",new s(null))}}},330:(t,e,n)=>{"use strict";n.d(e,{kA:()=>o,pz:()=>s,qj:()=>r,vG:()=>a});var i=n(2003);function o(t,e){return t?t.columns.getUnusedName(e):e}function r(t,e){return o(t,`molfile(${e})`)}function s(t){let e;if(t===i.YI.PT||t===i.YI.UN)e="PEPTIDE";else{if(t!==i.YI.RNA&&t!==i.YI.DNA)throw new Error(`Unexpected alphabet '${t}'.`);e="RNA"}return e}function a(t){const e=7===t.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t);return e?[parseInt(e[1],16)/256,parseInt(e[2],16)/256,parseInt(e[3],16)/256,e.length>4?parseInt(e[4],16)/256:.3]:null}},1093:(t,e,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(t,e,n)=>{"use strict";n.d(e,{e:()=>i});class i{static makePalette(t,e=!1,n=i){const o={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{o[t]=this.colourPalette[i][e?0:n]}))})),new n(o)}constructor(t){this._palette=t}get(t,e){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(t,e,n)=>{"use strict";n.d(e,{O:()=>r,n:()=>o});var i=n(1858);class o{constructor(t,e=!0,n){return this.substructure=t,this.readOnly=e,this.logger=n,new Proxy(this,{set:(t,e,n)=>{if(this.logger?.debug(`BioFilterProps.set ${e.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return t[e]=n,!0}})}}class r{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(t){this._propsChanging=!0;try{this._props=t,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const t={};for(const[e,n]of Object.entries(this.props))"_onChanged"!==e&&"logger"!==e&&(t[e]=this.props[e]);return t}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(t,e,n)=>{"use strict";var i=n(6082),o=n(7362),r=n(6718);function s(t,e=!0){if(null==t)return"rgb(100,100,100)";const n=i.Color.fromHtml(t);if(e){const t=i.Color.g(n),e=i.Color.r(n),o=i.Color.b(n),r=Math.sqrt(Math.pow(0-e,2)+Math.pow(0-t,2)+Math.pow(0-o,2));if(r>210)return`rgb(${e/r*210},${t/r*210},${o/r*210})`}return i.Color.toRgb(n)}class a{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,r.pj)().then((t=>{t.awaitLoaded(1/0).then((()=>{const e=t.getMonomerLib();e.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=e.getPolymerTypes();for(const t of this.polymerTypes){const n=e.getMonomerSymbolsByType(t);for(const i of n){const n=e.getMonomer(t,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][t]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(o.e.colourPalette))}get(t,e){const n=c.palette.length,i=c.customMonomerColors[t],o=e??"PEPTIDE";if(i&&i[o])return i[o];const r=a.hashCode(t)%n;return s(c.palette[r])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(t,e,n)=>{"use strict";n.d(e,{BG:()=>s,sD:()=>l});var i=n(4328),o=n(1858),r=n(8070);function s(t){let e=null,n=null;try{n=t.dart?t.gridColumn:null,e=n?n.temp:null}catch{[n,e]=[null,null]}const i=t.cell.column;if(e=e??(i?i.temp:null),!e)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,e]}class a{onKeyDown(t,e){}onKeyPress(t,e){}onMouseEnter(t,e){}onMouseLeave(t,e){}onMouseDown(t,e){}onMouseUp(t,e){}onMouseMove(t,e){}onClick(t,e){}onDoubleClick(t,e){}}class l extends a{constructor(t,e,n){super(),this.gridCol=t,this.tableCol=e,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new o.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((t=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(t){this.logger.error(t)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((t=>{try{const e=t.args.dataFrame;this.tableCol?.dataFrame.id!==e.id||this.destroyed||this.destroy()}catch(t){this.logger.error(t)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((t=>{try{const e=t.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===e.id&&!this.destroyed&&this.destroy()}catch(t){this.logger.error(t)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const t of this.subs)t.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(t){this.invalidateGrid()}async awaitRendered(t=1e4,e=`${t} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,r.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),t,`${n}, ${e}`),this.errors.length>0){const t=this.errors[0];throw this.errors=[],t}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(t,e,n)=>{"use strict";n.d(e,{s:()=>i});const i={true:"1",false:"0"}},6882:(t,e,n)=>{"use strict";n.d(e,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(t,e,n,i,r){if(super(t,e,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const t=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((e=>e.args.source===this.tableCol&&t.includes(e.args.key)))),200).subscribe((t=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&t.args.key===l.gp.positionShift))),200).subscribe((t=>{this.reset()})))}}calculateFontBasedSpacing(t){const e=t.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const t=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof t||isNaN(t)||(n=Math.max(t,1))}return{lineHeight:Math.max(1.4*n,e.fontBoundingBoxAscent+e.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(t){return"true"===t.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(t,e,n,i,o,r){const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(t),l=e-2*this.padding;let c=0;const h=[];if(i.length>0)for(let e=o;e<i.length;e++){const n=i.getOriginal(e),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:e}),c=Math.max(c,t.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const u=c;let d=Math.floor((l+a)/(u+a));d=Math.max(1,d);const p=n-2*this.padding,m=Math.max(0,Math.floor(p/s)),f=[];let g=0;for(let t=0;t<m&&g<h.length;t++){const e=[];for(let t=0;t<d&&g<h.length;t++){const n=h[g],i=this.padding+t*(u+a);e.push({posIdx:n.posIdx,x:i,width:u,om:n.text,isSeparator:!1}),g++}f.push({lineIdx:t,elements:e})}return{lineLayouts:f,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const t=await(0,h.pj)();this.sysMonomerLib=t.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(t){let e=12;return t&&t.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(e=Math.max(t.temp[".mm.cellRenderer.fontSize"],1)),{font:`${e}px monospace`,fontWidth:.6*e}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<e&&(this.colWidth=e,this.dirty=!0),this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(t){const e=new Array(t.length+1);e[0]=this.padding;for(let n=1;n<e.length;n++)e[n]=e[n-1]+t[n-1];let n=e[0];for(let t=1;t<e.length;t++)e[t]?n=e[t]:e[t]=n;return e}getCellMonomerLengthsForSeqValue(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(e/i)+o,s=n.splitter(t),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let t=o;t<a;++t){const i=s.getOriginal(t),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[t-o]=a,c+=a,c>e)break}return l}getCellMonomerLengthsForSeq(t){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const e=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+e,r=n.getSplitted(t),s=Math.min(o,r.length);let a=this._monomerLengthList[t];if(null===a||a.length!=s-e){a=this._monomerLengthList[t]=new Array(r.length);let i=0;for(let t=e;t<s;++t){const o=r.getOriginal(t),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[t-e]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var t;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const t=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return t&&t.dart?{startIdx:Math.max(Math.floor((t?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((t?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(t){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let t=n;t<i;t++){if(this._processedRows.get(t)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t,s),i=Math.min(s,n.length);i-r>e.length&&e.push(...new Array(i-r-e.length).fill(o));let a=0;for(let t=r;t<i;++t){const i=n.getOriginal(t),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(e[t-r]=Math.max(e[t-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(t,!0)}return e}getPosition(t,e,n,i){const[o,r]=this.getCellMonomerLengths(t,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t).length?null:function(t,e,n){if((n??0)>0&&e<(t[0]??0)+n)return-1;e-=n??0;let i,o=100,r=0,s=t.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),t[i]<=e&&e<t[i+1])return i;if(e<t[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(t)}. `)}return null}(r,e,i)}setMonomerLengthLimit(t){this.monomerLengthLimit!=t&&(this.monomerLengthLimit=t,this.dirty=!0)}setSeparatorWidth(t){this.separatorWidth!=t&&(this.props.separatorWidth=t,this.dirty=!0)}get positionShift(){const t=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(t)?0:Math.max(t,0)}render(t,e,n,i,r,a,c){const h=a.grid?.canvas===t.canvas;if(!this.seqHelper)return;const m=this.tableCol,f=this.positionShift;t.save();try{const c=this.seqHelper.getSeqHandler(m);let u=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const t=parseInt(m.getTag(d.gp.maxMonomerLength));u=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=u){let t=0;const e=8;t=m.temp[".mm.cellRenderer.gapLength"]??t,this.setMonomerLengthLimit(u),this.setSeparatorWidth(c.isMsa()?e:t),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false}const g=a.cell.rowIndex,b=a.cell.value;h&&(i=v(a.grid,t,e,i,window.devicePixelRatio)),t.beginPath(),t.rect(e,n,i,r),t.clip(),t.font=this.props?.font??"12px monospace",t.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),A=m.getTag(l.gp.separator)??"",S=h?c.getSplitted(g):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const E=m.temp["reference-sequence"],M=this.tableCol.temp["current-word"],T=(()=>{const t=(0,c.splitter)(null!=E&&""!==E?E:M??"");return s().count(0).take(t.length).slice(f).map((e=>t.getCanonical(e))).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)&&x!==d.yg.MSA){const s=[],l=this.calculateMultiLineLayoutDynamic(t,i,r,S,f,u);let h=n+this.padding;1===l.lineLayouts.length&&(h=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=h+i.lineIdx*l.lineHeight;for(const h of i.elements){const u=e+h.x,p=h,g=p.posIdx,b=S.getCanonical(g);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&T.length>0){const t=g-f;t>=0&&t<T.length&&b===T[t]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:g-f,bounds:new o.Rect(h.x,r-n,h.width,l.lineHeight),sequencePosition:g}),(0,d.oZ)(t,p.om,u,r,h.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:g})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(f)?t.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);h||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(S.length,Math.ceil(i/s)+f);for(let s=f;s<l;++s){const l=s<S.length?S.getOriginal(s):c.defaultGapOriginal,h=s<S.length?S.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,h));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:A,last:s===S.length-1,drawStyle:x,maxWord:o,wordIdx:s-f,gridCell:a,referenceSequence:T,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-f};(0,d.oZ)(t,l,e+this.padding+this._leftThreeDotsPadding,n,i,r,m)}if(this.shouldRenderShiftedThreeDots(f)){const s={color:y,pivot:0,left:!0,transparencyRate:0,separator:A,last:!1,drawStyle:x,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(t,"...",e+this.padding,n,i,r,s)}}}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n),this.errors.push(t)}finally{t.restore()}}shouldRenderShiftedThreeDots(t){return t>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(t,e){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==t.tableRowIndex)return;const o=this.positionShift,r=t.bounds,s=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=e.offsetY-r.y;this.gridCol?.grid?.canvas&&(this.gridCol.grid.canvas.style.cursor="default");let c=null;const h=this._cellBounds.get(t.tableRowIndex);if(h){for(const t of h)if(t.bounds.contains(s,a)){c=t.monomerIdx;break}}else{const e=this.shouldRenderShiftedThreeDots(o)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0;c=this.getPosition(t.tableRowIndex,s,r.width,e)}this.logger.debug(`${n}, argsX: ${s}, argsY: ${a}, left: ${c}`);const u=this.seqHelper.getSeqHandler(this.tableCol),d=u.getSplitted(t.tableRowIndex);if(null!==c&&c>=0&&c+o<d.length){const n=u.alphabet??l.YI.UN,r={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:d.getCanonical(c+o)},s=[];let a=this._monomerStructureMap[r.symbol];if(!a){const t=this.getMonomerLib();a=this._monomerStructureMap[r.symbol]=t?t.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),e.x+16,e.y+16),(0,f.WN)(t,r)}else-1===c?i.tooltip.show(i.divText(`${Math.min(o,d.length)} hidden monomers`),e.x+16,e.y+16):i.tooltip.hide(),(0,f.WN)(t,null)}}function v(t,e,n,i,o){return t?Math.max(Math.min(t.canvas.width/o-n,i)):Math.max(e.canvas.width/o-n,0)}},3856:(t,e,n)=>{"use strict";n.d(e,{Mn:()=>h,gp:()=>c,oZ:()=>p,yg:()=>u});var i=n(6082),o=n(7278);const r="rgb(100,100,100)",s="#808080",a="rgb(0,0,0)",l=o.zS;var c,h,u;!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(c||(c={})),function(t){t.applyToBackground=".m.cellRenderer.applyToBackground"}(h||(h={})),function(t){t.MSA="MSA",t.classic="classic"}(u||(u={}));const d=new class{constructor(){this.color=r,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=u.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(t,e,n,o,c,h,p){var m,f,g;const y={...d,...p};if(y.isMultiLineContext){t.textBaseline="middle",t.textAlign="center";let i=e;null!=y.maxLengthOfMonomer&&(i=l(i,y.maxLengthOfMonomer));const s=Math.max(.1,1-(y.transparencyRate??0));t.globalAlpha=s;const u=t.measureText(i),d=u.fontBoundingBoxAscent+u.fontBoundingBoxDescent,p=o+(h-d)/2+u.fontBoundingBoxAscent;let m=y.color??r;return m&&m!==r||(m=a),t.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(t.save(),t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n,o,c,h),t.restore(),t.fillStyle=m),t.fillText(i,n+c/2,p),t.globalAlpha=1,t.textBaseline="top",t.textAlign="start",n+c}p.logger?.debug("Bio: printLeftOrCentered(), start"),t.textAlign="start";let b=e.substring(0),v=y.last?"":y.separator;y.drawStyle===u.MSA&&(v="");let w=!0,C=!0,A="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(w=y.gridCell.cell.column.temp["color-code"]??!0,C=y.gridCell.cell.column.temp["compare-with-current"]??!0,A=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const t=y.referenceSequence[y.wordIdx];C&&y.referenceSequence.length>0&&"difference"===A&&(y.transparencyRate=b==t?.7:y.transparencyRate),C&&y.referenceSequence.length>0&&"equal"===A&&(y.transparencyRate=b!=t?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=l(b,y.maxLengthOfMonomer));const S=b+v;(m=y.monomerTextSizeMap)[S]??(m[S]=t.measureText(S));let x=y.monomerTextSizeMap[S];(f=y.monomerTextSizeMap)[b]??(f[b]=t.measureText(b));let E=y.monomerTextSizeMap[b].width;const M=h/2-(x.fontBoundingBoxAscent+x.fontBoundingBoxDescent)/2+1;(g=y.monomerTextSizeMap)[v]??(g[v]=t.measureText(v));const T=y.monomerTextSizeMap[v].width;function _(e,r){let l=w?y.color:a;y.selectedPosition===y.wordIdx+1&&(t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n+e-4,o-5,y.monomerTextSizeMap[b].width+8,h+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),t.fillStyle=l,t.globalAlpha=1-y.transparencyRate,y.drawStyle===u.classic&&(t.fillText(b,n+e,o+M),t.fillStyle=s,t.fillText(v,n+r,o+M)),y.drawStyle===u.MSA&&t.fillText(b,n+e,o+M),t.globalAlpha=1}x=x.width,y.drawStyle===u.MSA&&(E=y.maxWord[y.wordIdx],x=y.maxWord[y.wordIdx]);const I=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||x>c)return _(I,I+E),n+I+E+T;{const t=(c-x)/2;return _(t,t+E),n+I+t+E}}},6307:(t,e,n)=>{"use strict";n.d(e,{F:()=>s});var i=n(7389),o=n(6082),r=n(439);function s(t,e,n){let s=0,a=null;for(const e of Object.values(t))s+=e,a=null===a?e:Math.max(a,e);const l=a/s,c=Object.assign({},...Array.from(Object.entries(t)).sort(((t,e)=>e[1]-t[1])).map((([t,a])=>{const c=a/s;let h;try{const i=n.getMonomerColors(e,t);h=i?.backgroundcolor||"#CCCCCC"}catch(e){console.warn(`Failed to get colors for monomer ${t}:`,e),h="#CCCCCC"}const u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/l+"px",u.style.backgroundColor=h,r._S===t&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=o.Color.toHtml(o.Color.lightGray));const d=r._S===t?"-":t,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),h}},3151:(t,e,n)=>{"use strict";n.d(e,{EK:()=>l,Ec:()=>r,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>o});const i=["symbol","molfile","rgroups","name"],o="MonomerName",r={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(t,e,n)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function o(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?o(t.$thrownJsError):void 0}function r(t){return[i(t),o(t)]}n.d(e,{AP:()=>r})},3516:(t,e,n)=>{"use strict";n.d(e,{m:()=>r});var i=n(6082),o=n(439);class r{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.meta.units=o.Hi.FASTA,[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6873:(t,e,n)=>{"use strict";n.d(e,{Hx:()=>h,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(t=10**5){const e="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(t/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function h(t,e=s.Hi.SEPARATOR,n=s.YI.PT,o=(e===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=e,f.setTag(s.gp.alphabet,n),e==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,o);const g=t.getSeqHandler(f);for(let t=0;t<u;t++){const n=r().count(0).take(d).map((t=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[e]));f.set(t,i)}return f}},439:(t,e,n)=>{"use strict";n.d(e,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>o,_S:()=>u,b9:()=>d,gp:()=>r,q7:()=>h,z1:()=>a});var i,o,r,s=n(2738);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm",t.CUSTOM="custom"}(i||(i={})),function(t){t.DNA="DNA",t.RNA="RNA",t.PT="PT",t.UN="UN"}(o||(o={})),function(t){t.aligned="aligned",t.alphabet="alphabet",t.alphabetSize=".alphabetSize",t.alphabetIsMultichar=".alphabetIsMultichar",t.separator="separator",t.isHelmCompatible=".isHelmCompatible",t.positionNames=".positionNames",t.positionLabels=".positionLabels",t.regions=".regions",t.positionShift=".positionShift",t.selectedPosition=".selectedPosition"}(r||(r={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(o.PT,c.fasta.peptide,.5),new 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i=n(4328),o=n(6082),r=n(1991),s=n.n(r),a=n(439),l=n(3561),c=n(9235),h=n(294),u=n(9192),d=n(330),p=n(8123);async function m(t,e,n,r,l){if(e.semType!==o.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${o.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let h=e;const p=r.getSeqHandler(e);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=e.name);try{g=r.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(t){const[e,n]=(0,u.AP)(t);return{molCol:null,warnings:[e]}}const y=function(t,e){const n=t.length,o=new Array(n),r=e.getSeqHandler(t);let a=!1;const l=r.defaultBiotype;for(let t=0;t<n;++t){const e=r.getSplitted(t);a||(a=0===e.length),o[t]=s().count(0).take(e.length).filter((t=>!e.isGap(t))).map((t=>({position:t,biotype:l,symbol:e.getCanonical(t)}))).toArray()}return a&&i.shell.warning(`Some values in the "${t.name}" column are 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c=function(t,e){return(0,l.YN)(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:n[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:n[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=c)for(let t=0;t<n.length;++t)n[t]=(0,l.YN)(n[t]/c),i[t]=(0,l.YN)(i[t]/c)}(v,o),function(t,e,n){if("PEPTIDE"===t){b(e,t);const n=w(e,e.meta.rNodes[1]);n?.removedAtom&&(e.terminalR2Atom=n.removedAtom)}else n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),b(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],T(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),b(e,t),w(e,e.meta.rNodes[1]))}(i,v,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===p.u.HYDROGEN&&(w(t,e+1),--e),++e}(v),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)"oh"===t.atoms.atomTypes[e]?.toLowerCase()&&(t.atoms.atomTypes[e]="O"),"?"===t.atoms.atomTypes[e]&&(t.atoms.atomTypes[e]="H"),++e}(v),function(t){const e=" RGROUPS=(1 1)";for(let n=0;n<(t.atoms.kwargs?.length??0);n++){const i=t.atoms.kwargs[n];i&&i.includes(e)&&(t.atoms.kwargs[n]=i.replace(e,""))}}(v),v}var r;return null}(e,n,i,o,r);if(!a)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);(0,h.LQ)(t,s,a)}}function y(t,e){const n=e.rNodes;e.terminalNodes=new Array(n.length).fill(0);const i=e.terminalNodes,o=t.atomPairs;let r=0,s=0;for(;r<o.length&&s<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)o[r][e]===n[t]&&(i[t]=o[r][(e+1)%2],n.length,++s);++r}}function b(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=v(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=v(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function v(t,e,n){return[(0,l.YN)(t.atoms.x[e]-t.atoms.x[n]),(0,l.YN)(t.atoms.y[e]-t.atoms.y[n])]}function w(t,e){if(void 0!==e){const n=e-1,i=t.atoms,o=t.bonds,r=t.meta,s=i.atomTypes.splice(n,1)[0];i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let t=0;t<r.terminalNodes.length;++t)r.terminalNodes[t]>e?--r.terminalNodes[t]:r.terminalNodes[t]===e&&(r.terminalNodes[t]=-1);for(let t=0;t<r.rNodes.length;++t)r.rNodes[t]>e?--r.rNodes[t]:r.rNodes[t]===e&&(r.rNodes[t]=-1);let a=0;for(;a<o.atomPairs.length;){const t=o.atomPairs[a][0],n=o.atomPairs[a][1];t===e||n===e?(o.atomPairs.splice(a,1),o.bondTypes=C(Uint32Array,o.bondTypes,a,1),o.bondConfiguration.has(a)&&o.bondConfiguration.delete(a),o.kwargs.has(a)&&o.kwargs.delete(a),--a):(o.atomPairs[a][0]=t>e?t-1:t,o.atomPairs[a][1]=n>e?n-1:n),++a}let l=Array.from(o.bondConfiguration.keys());return l.forEach((t=>{if(o.bondConfiguration.has(t)&&t>n){const e=o.bondConfiguration.get(t);o.bondConfiguration.delete(t),o.bondConfiguration.set(t-1,e)}})),l=Array.from(o.kwargs.keys()),l.forEach((t=>{if(o.kwargs.has(t)&&t>n){const e=o.kwargs.get(t);o.kwargs.delete(t),o.kwargs.set(t-1,e)}})),s?{removedAtom:s}:void 0}}function C(t,e,n,i){const o=new t(e.length-i);let r=0,s=0;for(;r<e.length;)r===n&&(r+=i),o[s]=e[r],++s,++r;return o}function A(t,e){let n;if(0===t)n=e>0?0:Math.PI;else if(0===e)n=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,o=Math.atan(i);n=t<0?Math.PI/2+o:-Math.PI/2+o}return n}function S(t,e){if(0!==e){const n=t.x,i=t.y,o=Math.cos(e),r=Math.sin(e);for(let t=0;t<n.length;++t){const e=n[t];n[t]=(0,l.YN)(e*o-i[t]*r),i[t]=(0,l.YN)(e*r+i[t]*o)}}}function x(t){E(t,!1)}function E(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const n=t.bonds.bondConfiguration;for(const[t,e]of n){const i=1===e?3:1;n.set(t,i)}}function T(t,e,n){const i=t.atoms.x,o=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=(0,l.YN)(i[t]+e),void 0!==n&&(o[t]=(0,l.YN)(o[t]+n))}},294:(t,e,n)=>{"use strict";function i(t,e){return t[e.polymerType]?.[e.symbol]}function o(t,e){return!!t[e.polymerType]?.[e.symbol]}function r(t,e,n){let i=t[e.polymerType];i||(i=t[e.polymerType]={}),i[e.symbol]=n}n.d(e,{Cg:()=>s,LQ:()=>r,bq:()=>o,vF:()=>a,xb:()=>i});class s extends Map{constructor(t){super(t)}}class a{constructor(t,e){this.molfile=t,this.monomers=e}static createEmpty(){return new a("",new s(null))}}},330:(t,e,n)=>{"use strict";n.d(e,{kA:()=>o,pz:()=>s,qj:()=>r,vG:()=>a});var i=n(2003);function o(t,e){return t?t.columns.getUnusedName(e):e}function r(t,e){return o(t,`molfile(${e})`)}function s(t){let e;if(t===i.YI.PT||t===i.YI.UN)e="PEPTIDE";else{if(t!==i.YI.RNA&&t!==i.YI.DNA)throw new Error(`Unexpected alphabet '${t}'.`);e="RNA"}return e}function a(t){const e=7===t.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t);return e?[parseInt(e[1],16)/256,parseInt(e[2],16)/256,parseInt(e[3],16)/256,e.length>4?parseInt(e[4],16)/256:.3]:null}},1093:(t,e,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(t,e,n)=>{"use strict";n.d(e,{e:()=>i});class i{static makePalette(t,e=!1,n=i){const o={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{o[t]=this.colourPalette[i][e?0:n]}))})),new n(o)}constructor(t){this._palette=t}get(t,e){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 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180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(t,e,n)=>{"use strict";n.d(e,{O:()=>r,n:()=>o});var i=n(1858);class o{constructor(t,e=!0,n){return this.substructure=t,this.readOnly=e,this.logger=n,new Proxy(this,{set:(t,e,n)=>{if(this.logger?.debug(`BioFilterProps.set ${e.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return t[e]=n,!0}})}}class r{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(t){this._propsChanging=!0;try{this._props=t,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const t={};for(const[e,n]of Object.entries(this.props))"_onChanged"!==e&&"logger"!==e&&(t[e]=this.props[e]);return t}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(t,e,n)=>{"use strict";var i=n(6082),o=n(7362),r=n(6718);function s(t,e=!0){if(null==t)return"rgb(100,100,100)";const n=i.Color.fromHtml(t);if(e){const t=i.Color.g(n),e=i.Color.r(n),o=i.Color.b(n),r=Math.sqrt(Math.pow(0-e,2)+Math.pow(0-t,2)+Math.pow(0-o,2));if(r>210)return`rgb(${e/r*210},${t/r*210},${o/r*210})`}return i.Color.toRgb(n)}class a{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,r.pj)().then((t=>{t.awaitLoaded(1/0).then((()=>{const e=t.getMonomerLib();e.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=e.getPolymerTypes();for(const t of this.polymerTypes){const n=e.getMonomerSymbolsByType(t);for(const i of n){const n=e.getMonomer(t,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][t]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(o.e.colourPalette))}get(t,e){const n=c.palette.length,i=c.customMonomerColors[t],o=e??"PEPTIDE";if(i&&i[o])return i[o];const r=a.hashCode(t)%n;return s(c.palette[r])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(t,e,n)=>{"use strict";n.d(e,{BG:()=>s,sD:()=>l});var i=n(4328),o=n(1858),r=n(8070);function s(t){let e=null,n=null;try{n=t.dart?t.gridColumn:null,e=n?n.temp:null}catch{[n,e]=[null,null]}const i=t.cell.column;if(e=e??(i?i.temp:null),!e)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,e]}class a{onKeyDown(t,e){}onKeyPress(t,e){}onMouseEnter(t,e){}onMouseLeave(t,e){}onMouseDown(t,e){}onMouseUp(t,e){}onMouseMove(t,e){}onClick(t,e){}onDoubleClick(t,e){}}class l extends a{constructor(t,e,n){super(),this.gridCol=t,this.tableCol=e,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new o.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((t=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(t){this.logger.error(t)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((t=>{try{const e=t.args.dataFrame;this.tableCol?.dataFrame.id!==e.id||this.destroyed||this.destroy()}catch(t){this.logger.error(t)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((t=>{try{const e=t.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===e.id&&!this.destroyed&&this.destroy()}catch(t){this.logger.error(t)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const t of this.subs)t.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(t){this.invalidateGrid()}async awaitRendered(t=1e4,e=`${t} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,r.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),t,`${n}, ${e}`),this.errors.length>0){const t=this.errors[0];throw this.errors=[],t}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(t,e,n)=>{"use strict";n.d(e,{s:()=>i});const i={true:"1",false:"0"}},6882:(t,e,n)=>{"use strict";n.d(e,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),o=n(6082),r=n(1991),s=n.n(r),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(t,e,n,i,r){if(super(t,e,n),this.monomerLengthLimit=i,this.propsProvider=r,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this._ellipsisBounds=void 0,this._totalLinesNeeded=0,this._lineHeight=20,this._cellBounds=new Map,this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=o.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol){this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{-1===this.tableCol.dataFrame.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})));const t=[l.gp.positionShift,"renderMultiline"];this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((e=>e.args.source===this.tableCol&&t.includes(e.args.key)))),200).subscribe((t=>{this.reset()}))),this.subs.push(o.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&t.args.key===l.gp.positionShift))),200).subscribe((t=>{this.reset()})))}}calculateFontBasedSpacing(t){const e=t.measureText("M");let n=12;if(this.tableCol?.temp[".mm.cellRenderer.fontSize"]){const t=this.tableCol.temp[".mm.cellRenderer.fontSize"];"number"!=typeof t||isNaN(t)||(n=Math.max(t,1))}return{lineHeight:Math.max(1.4*n,e.fontBoundingBoxAscent+e.fontBoundingBoxDescent+4),monomerSpacing:Math.max(2,.2*this.props.fontCharWidth)}}shouldUseMultilineRendering(t){return"true"===t.getTag("renderMultiline")}calculateMultiLineLayoutDynamic(t,e,n,i,o,r){if(this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const{lineHeight:s,monomerSpacing:a}=this.calculateFontBasedSpacing(t),l=e-2*this.padding;let c=0;const h=[];if(i.length>0)for(let e=o;e<i.length;e++){const n=i.getOriginal(e),o=this.props.monomerToShort(n,r);h.push({text:o,posIdx:e}),c=Math.max(c,t.measureText(o).width)}if(0===h.length)return{lineLayouts:[],lineHeight:s};const d=c;let p=Math.floor((l+a)/(d+a));p=Math.max(1,p);const m=n-2*this.padding,f=Math.max(0,Math.floor(m/s)),g=[];let y=0;for(let t=0;t<f&&y<h.length;t++){const e=[];for(let t=0;t<p&&y<h.length;t++){const n=h[y],i=this.padding+t*(d+a);e.push({posIdx:n.posIdx,x:i,width:d,om:n.text,isSeparator:!1}),y++}g.push({lineIdx:t,elements:e})}return{lineLayouts:g,lineHeight:s}}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const t=await(0,h.pj)();this.sysMonomerLib=t.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(t){let e=12;return t&&t.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(e=Math.max(t.temp[".mm.cellRenderer.fontSize"],1)),{font:`${e}px monospace`,fontWidth:.6*e}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=o.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},this._cellBounds.clear(),super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<e&&(this.colWidth=e,this.dirty=!0),this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(t){const e=new Array(t.length+1);e[0]=this.padding;for(let n=1;n<e.length;n++)e[n]=e[n-1]+t[n-1];let n=e[0];for(let t=1;t<e.length;t++)e[t]?n=e[t]:e[t]=n;return e}getCellMonomerLengthsForSeqValue(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,r=Math.ceil(e/i)+o,s=n.splitter(t),a=Math.min(r,s.length),l=new Array(a-o);let c=0;for(let t=o;t<a;++t){const i=s.getOriginal(t),r=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(l[t-o]=a,c+=a,c>e)break}return l}getCellMonomerLengthsForSeq(t){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const e=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/i)+e,r=n.getSplitted(t),s=Math.min(o,r.length);let a=this._monomerLengthList[t];if(null===a||a.length!=s-e){a=this._monomerLengthList[t]=new Array(r.length);let i=0;for(let t=e;t<s;++t){const o=r.getOriginal(t),s=this.props.monomerToShort(o,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[t-e]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqMsa(){var t;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const t=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return t&&t.dart?{startIdx:Math.max(Math.floor((t?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((t?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(t){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),o=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,s=Math.ceil(this.colWidth/o)+r;for(let t=n;t<i;t++){if(this._processedRows.get(t)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t,s),i=Math.min(s,n.length);i-r>e.length&&e.push(...new Array(i-r-e.length).fill(o));let a=0;for(let t=r;t<i;++t){const i=n.getOriginal(t),o=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+o.length*this.props.fontCharWidth;if(e[t-r]=Math.max(e[t-r]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(t,!0)}return e}getPosition(t,e,n,i){const[o,r]=this.getCellMonomerLengths(t,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t).length?null:function(t,e,n){if((n??0)>0&&e<(t[0]??0)+n)return-1;e-=n??0;let i,o=100,r=0,s=t.length-1;for(;r<=s;){if(i=Math.floor((s+r)/2),t[i]<=e&&e<t[i+1])return i;if(e<t[i]?s=i-1:r=i+1,--o<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(t)}. `)}return null}(r,e,i)}setMonomerLengthLimit(t){this.monomerLengthLimit!=t&&(this.monomerLengthLimit=t,this.dirty=!0)}setSeparatorWidth(t){this.separatorWidth!=t&&(this.props.separatorWidth=t,this.dirty=!0)}get positionShift(){const t=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(t)?0:Math.max(t,0)}render(t,e,n,i,r,a,c){const h=a.grid?.canvas===t.canvas;if(!this.seqHelper)return;const m=this.tableCol,f=this.positionShift;t.save();try{const c=this.seqHelper.getSeqHandler(m);let u=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const t=parseInt(m.getTag(d.gp.maxMonomerLength));u=!isNaN(t)&&t?t:50}if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=u){let t=0;const e=8;t=m.temp[".mm.cellRenderer.gapLength"]??t,this.setMonomerLengthLimit(u),this.setSeparatorWidth(c.isMsa()?e:t),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false,this.dirty=!0}const g=a.cell.rowIndex,b=a.cell.value;h&&(i=v(a.grid,t,e,i,window.devicePixelRatio)),t.beginPath(),t.rect(e,n,i,r),t.clip(),t.font=this.props?.font??"12px monospace",t.textBaseline="top";const w=m.meta.units,C=m.getTag(l.gp.aligned),A=m.getTag(l.gp.separator)??"",S=h?c.getSplitted(g):c.splitter(b);let x=d.yg.classic;C?.includes("MSA")&&w===l.Hi.SEPARATOR&&(x=d.yg.MSA);const E=m.temp["reference-sequence"],T=this.tableCol.temp["current-word"],M=(()=>{const t=(0,c.splitter)(null!=E&&""!==E?E:T??"");return s().count(0).take(t.length).slice(f).map((e=>t.getCanonical(e))).toArray()})(),_=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200");if(this.shouldUseMultilineRendering(m)){const s=[],l=this.calculateMultiLineLayoutDynamic(t,i,r,S,f,u);let h=n+this.padding;1===l.lineLayouts.length&&(h=n+(r-l.lineHeight)/2);for(const i of l.lineLayouts){const r=h+i.lineIdx*l.lineHeight;for(const h of i.elements){const u=e+h.x,p=h,g=p.posIdx,b=S.getCanonical(g);let v=y;const w=this.getMonomerLib();w&&(v=w.getMonomerTextColor(c.defaultBiotype,b));let C=0;if(a.tableRowIndex!==m.dataFrame.currentRowIdx&&M.length>0){const t=g-f;t>=0&&t<M.length&&b===M[t]&&(C=.7)}s.push({lineIdx:i.lineIdx,monomerIdx:g-f,bounds:new o.Rect(h.x,r-n,h.width,l.lineHeight),sequencePosition:g}),(0,d.oZ)(t,p.om,u,r,h.width,l.lineHeight,{color:v,isMultiLineContext:!0,transparencyRate:C,selectedPosition:isNaN(_)||_<1?void 0:_,wordIdx:g})}}null!==a.tableRowIndex&&this._cellBounds.set(a.tableRowIndex,s)}else{this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(f)?t.measureText("...").width:0;let[,o]=this.getCellMonomerLengths(a.tableRowIndex,i);h||(o=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(b,i)));const s=this.props.separatorWidth+1*this.props.fontCharWidth,l=Math.min(S.length,Math.ceil(i/s)+f);for(let s=f;s<l;++s){const l=s<S.length?S.getOriginal(s):c.defaultGapOriginal,h=s<S.length?S.getCanonical(s):c.defaultGapOriginal;let p=y;this.getMonomerLib()&&(p=this.getMonomerLib().getMonomerTextColor(c.defaultBiotype,h));const m={color:p,pivot:0,left:!0,transparencyRate:0,separator:A,last:s===S.length-1,drawStyle:x,maxWord:o,wordIdx:s-f,gridCell:a,referenceSequence:M,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(_)||_<1?void 0:_-f};(0,d.oZ)(t,l,e+this.padding+this._leftThreeDotsPadding,n,i,r,m)}if(this.shouldRenderShiftedThreeDots(f)){const s={color:y,pivot:0,left:!0,transparencyRate:0,separator:A,last:!1,drawStyle:x,maxWord:o,wordIdx:0,gridCell:a,maxLengthOfMonomer:u,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(t,"...",e+this.padding,n,i,r,s)}}}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n),this.errors.push(t)}finally{t.restore()}}shouldRenderShiftedThreeDots(t){return t>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(t,e){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==t.tableRowIndex)return;const o=this.positionShift,r=t.bounds,s=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=e.offsetY-r.y;this.gridCol?.grid?.canvas&&(this.gridCol.grid.canvas.style.cursor="default");let c=null;const h=this._cellBounds.get(t.tableRowIndex);if(h){for(const t of h)if(t.bounds.contains(s,a)){c=t.monomerIdx;break}}else{const e=this.shouldRenderShiftedThreeDots(o)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0;c=this.getPosition(t.tableRowIndex,s,r.width,e)}this.logger.debug(`${n}, argsX: ${s}, argsY: ${a}, left: ${c}`);const u=this.seqHelper.getSeqHandler(this.tableCol),d=u.getSplitted(t.tableRowIndex);if(null!==c&&c>=0&&c+o<d.length){const n=u.alphabet??l.YI.UN,r={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:d.getCanonical(c+o)},s=[];let a=this._monomerStructureMap[r.symbol];if(!a){const t=this.getMonomerLib();a=this._monomerStructureMap[r.symbol]=t?t.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),e.x+16,e.y+16),(0,f.WN)(t,r)}else-1===c?i.tooltip.show(i.divText(`${Math.min(o,d.length)} hidden monomers`),e.x+16,e.y+16):i.tooltip.hide(),(0,f.WN)(t,null)}}function v(t,e,n,i,o){return t?Math.max(Math.min(t.canvas.width/o-n,i)):Math.max(e.canvas.width/o-n,0)}},3856:(t,e,n)=>{"use strict";n.d(e,{Mn:()=>h,gp:()=>c,oZ:()=>p,yg:()=>u});var i=n(6082),o=n(7278);const r="rgb(100,100,100)",s="#808080",a="rgb(0,0,0)",l=o.zS;var c,h,u;!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(c||(c={})),function(t){t.applyToBackground=".m.cellRenderer.applyToBackground"}(h||(h={})),function(t){t.MSA="MSA",t.classic="classic"}(u||(u={}));const d=new class{constructor(){this.color=r,this.pivot=0,this.left=!1,this.transparencyRate=0,this.separator="",this.last=!1,this.drawStyle=u.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0,this.isMultiLineContext=!1,this.lineNumber=0}};function p(t,e,n,o,c,h,p){var m,f,g;const y={...d,...p};if(y.isMultiLineContext){t.textBaseline="middle",t.textAlign="center";let i=e;null!=y.maxLengthOfMonomer&&(i=l(i,y.maxLengthOfMonomer));const s=Math.max(.1,1-(y.transparencyRate??0));t.globalAlpha=s;const u=t.measureText(i),d=u.fontBoundingBoxAscent+u.fontBoundingBoxDescent,p=o+(h-d)/2+u.fontBoundingBoxAscent;let m=y.color??r;return m&&m!==r||(m=a),t.fillStyle=m,y.selectedPosition===y.wordIdx+1&&(t.save(),t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n,o,c,h),t.restore(),t.fillStyle=m),t.fillText(i,n+c/2,p),t.globalAlpha=1,t.textBaseline="top",t.textAlign="start",n+c}p.logger?.debug("Bio: printLeftOrCentered(), start"),t.textAlign="start";let b=e.substring(0),v=y.last?"":y.separator;y.drawStyle===u.MSA&&(v="");let w=!0,C=!0,A="difference";if(null!=y.gridCell&&null!=y.gridCell.cell.column&&(w=y.gridCell.cell.column.temp["color-code"]??!0,C=y.gridCell.cell.column.temp["compare-with-current"]??!0,A=y.gridCell.cell.column.temp["highlight-difference"]??"difference"),y.referenceSequence){const t=y.referenceSequence[y.wordIdx];C&&y.referenceSequence.length>0&&"difference"===A&&(y.transparencyRate=b==t?.7:y.transparencyRate),C&&y.referenceSequence.length>0&&"equal"===A&&(y.transparencyRate=b!=t?.7:y.transparencyRate)}null!=y.maxLengthOfMonomer&&(b=l(b,y.maxLengthOfMonomer));const S=b+v;(m=y.monomerTextSizeMap)[S]??(m[S]=t.measureText(S));let x=y.monomerTextSizeMap[S];(f=y.monomerTextSizeMap)[b]??(f[b]=t.measureText(b));let E=y.monomerTextSizeMap[b].width;const T=h/2-(x.fontBoundingBoxAscent+x.fontBoundingBoxDescent)/2+1;(g=y.monomerTextSizeMap)[v]??(g[v]=t.measureText(v));const M=y.monomerTextSizeMap[v].width;function _(e,r){let l=w?y.color:a;y.selectedPosition===y.wordIdx+1&&(t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n+e-4,o-5,y.monomerTextSizeMap[b].width+8,h+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),t.fillStyle=l,t.globalAlpha=1-y.transparencyRate,y.drawStyle===u.classic&&(t.fillText(b,n+e,o+T),t.fillStyle=s,t.fillText(v,n+r,o+T)),y.drawStyle===u.MSA&&t.fillText(b,n+e,o+T),t.globalAlpha=1}x=x.width,y.drawStyle===u.MSA&&(E=y.maxWord[y.wordIdx],x=y.maxWord[y.wordIdx]);const I=(y.maxWord[y.wordIdx]??0)-(y.maxWord[0]??0);if(y.left||x>c)return _(I,I+E),n+I+E+M;{const t=(c-x)/2;return _(t,t+E),n+I+t+E}}},6307:(t,e,n)=>{"use strict";n.d(e,{F:()=>s});var i=n(7389),o=n(6082),r=n(439);function s(t,e,n){let s=0,a=null;for(const e of Object.values(t))s+=e,a=null===a?e:Math.max(a,e);const l=a/s,c=Object.assign({},...Array.from(Object.entries(t)).sort(((t,e)=>e[1]-t[1])).map((([t,a])=>{const c=a/s;let h;try{const i=n.getMonomerColors(e,t);h=i?.backgroundcolor||"#CCCCCC"}catch(e){console.warn(`Failed to get colors for monomer ${t}:`,e),h="#CCCCCC"}const u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/l+"px",u.style.backgroundColor=h,r._S===t&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=o.Color.toHtml(o.Color.lightGray));const d=r._S===t?"-":t,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),h}},3151:(t,e,n)=>{"use strict";n.d(e,{EK:()=>l,Ec:()=>r,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>o});const i=["symbol","molfile","rgroups","name"],o="MonomerName",r={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(t,e,n)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function o(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?o(t.$thrownJsError):void 0}function r(t){return[i(t),o(t)]}n.d(e,{AP:()=>r})},3516:(t,e,n)=>{"use strict";n.d(e,{m:()=>r});var i=n(6082),o=n(439);class r{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.meta.units=o.Hi.FASTA,[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6873:(t,e,n)=>{"use strict";n.d(e,{Hx:()=>h,dW:()=>c});var i=n(6082),o=n(1991),r=n.n(o),s=n(2003),a=n(7278),l=n(439);function c(t=10**5){const e="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(t/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const o=[];return o.push(n),o.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),o}function h(t,e=s.Hi.SEPARATOR,n=s.YI.PT,o=(e===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=e,f.setTag(s.gp.alphabet,n),e==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,o);const g=t.getSeqHandler(f);for(let t=0;t<u;t++){const n=r().count(0).take(d).map((t=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[e]));f.set(t,i)}return f}},439:(t,e,n)=>{"use strict";n.d(e,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>o,_S:()=>u,b9:()=>d,gp:()=>r,ot:()=>p,q7:()=>h,z1:()=>a});var i,o,r,s=n(2738);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm",t.CUSTOM="custom"}(i||(i={})),function(t){t.DNA="DNA",t.RNA="RNA",t.PT="PT",t.UN="UN"}(o||(o={})),function(t){t.aligned="aligned",t.alphabet="alphabet",t.alphabetSize=".alphabetSize",t.alphabetIsMultichar=".alphabetIsMultichar",t.separator="separator",t.isHelmCompatible=".isHelmCompatible",t.positionNames=".positionNames",t.positionLabels=".positionLabels",t.regions=".regions",t.positionShift=".positionShift",t.selectedPosition=".selectedPosition"}(r||(r={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(o.PT,c.fasta.peptide,.5),new s.a(o.DNA,c.fasta.dna,.55),new s.a(o.RNA,c.fasta.rna,.55)],u="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"},p=" , "},2003:(t,e,n)=>{"use 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o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return delete o.attributes[i],this.emit("edgeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:i}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new W("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new W("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,s=""+i;if(i=arguments[2],!(o=l(this,r,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new W("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other 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n=n.next,{done:!1,value:t}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function at(t,e,n,i){if(0!==e.size)for(var o,r,s="mixed"!==n&&n!==e.type,a="undirected"===n,l=!1,c=e._edges.values();!0!==(o=c.next()).done;)if(r=o.value,!s||r.undirected===a){var h=r,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,r.undirected),t&&l)return u}}function lt(t,e,n,i,o,r){var s,a=e?nt:et;if("undirected"!==n){if("out"!==i&&(s=a(t,o.in,r),t&&s))return s;if("in"!==i&&(s=a(t,o.out,r,i?void 0:o.key),t&&s))return s}if("directed"!==n&&(s=a(t,o.undirected,r),t&&s))return s}function ct(t,e,n,i,o,r,s){var a,l=n?rt:ot;if("undirected"!==e){if(void 0!==o.in&&"out"!==i&&(a=l(t,o.in,r,s),t&&a))return a;if(void 0!==o.out&&"in"!==i&&(i||o.key!==r)&&(a=l(t,o.out,r,s),t&&a))return a}if("directed"!==e&&void 0!==o.undirected&&(a=l(t,o.undirected,r,s),t&&a))return a}var ht=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ut(){this.A=null,this.B=null}function dt(t,e,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!e||!e.has(c.key)){var h=o(c.key,c.attributes);if(t&&h)return c.key}}}function pt(t,e,n,i,o){if("mixed"!==e){if("undirected"===e)return dt(t,null,i,i.undirected,o);if("string"==typeof n)return dt(t,null,i,i[n],o)}var r,s=new ut;if("undirected"!==e){if("out"!==n){if(r=dt(t,null,i,i.in,o),t&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=dt(t,s,i,i.out,o),t&&r)return r;s.wrap(i.out)}}if("directed"!==e&&(r=dt(t,s,i,i.undirected,o),t&&r))return r}function mt(t,e,n){var i=Object.keys(n),o=i.length,r=0;return new N((function(){var s=null;do{if(r>=o)return t&&t.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===e?c:l,t&&t.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ft(t,e,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(e&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),t&&u))return null}}function gt(t){if(!c(t))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in t))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function yt(t){if(!c(t))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in t))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in t))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in t&&"boolean"!=typeof t.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ut.prototype.wrap=function(t){null===this.A?this.A=t:null===this.B&&(this.B=t)},ut.prototype.has=function(t){return null!==this.A&&t in this.A||null!==this.B&&t in this.B};var bt,vt=(bt=255&Math.floor(256*Math.random()),function(){return bt++}),wt=new Set(["directed","undirected","mixed"]),Ct=new Set(["domain","_events","_eventsCount","_maxListeners"]),At={allowSelfLoops:!0,multi:!1,type:"mixed"};function St(t,e,n){var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}function xt(t,e,n,i,o,r,s,a){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=t._nodes.get(r),h=t._nodes.get(s);if(!l)throw new V("Graph.".concat(e,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(e,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));if(!t.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(e,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);t._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,t._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,u.key=o,t.emit("edgeAdded",u),o}function Et(t,e,n,i,o,r,s,l,h){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(e,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=t._nodes.get(r),f=t._nodes.get(s);if(!n&&(d=t._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(e,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||t.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),t.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),t.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=St(t,r,{}),v=!0,r===s&&(f=m,w=!0)),f||(f=St(t,s,{}),w=!0),d=new z(i,o,m,f,l),t._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,t._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,b.key=o,t.emit("edgeAdded",b),[o,!0,v,w]}function Mt(t,e){t._edges.delete(e.key);var n=e.source,i=e.target,o=e.attributes,r=e.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,t._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,t._directedSelfLoopCount--)),t.multi?e.detachMulti():e.detach(),r?t._undirectedSize--:t._directedSize--,t.emit("edgeDropped",{key:e.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Tt=function(n){function i(t){var e;if(e=n.call(this)||this,"boolean"!=typeof(t=a({},At,t)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(t.multi,'".'));if(!wt.has(t.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(t.type,'".'));if("boolean"!=typeof t.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(t.allowSelfLoops,'".'));var i="mixed"===t.type?U:"directed"===t.type?j:q;u(s(e),"NodeDataClass",i);var o="geid_"+vt()+"_",r=0;return u(s(e),"_attributes",{}),u(s(e),"_nodes",new Map),u(s(e),"_edges",new Map),u(s(e),"_directedSize",0),u(s(e),"_undirectedSize",0),u(s(e),"_directedSelfLoopCount",0),u(s(e),"_undirectedSelfLoopCount",0),u(s(e),"_edgeKeyGenerator",(function(){var t;do{t=o+r++}while(e._edges.has(t));return t})),u(s(e),"_options",t),Ct.forEach((function(t){return u(s(e),t,e[t])})),d(s(e),"order",(function(){return e._nodes.size})),d(s(e),"size",(function(){return e._edges.size})),d(s(e),"directedSize",(function(){return e._directedSize})),d(s(e),"undirectedSize",(function(){return e._undirectedSize})),d(s(e),"selfLoopCount",(function(){return e._directedSelfLoopCount+e._undirectedSelfLoopCount})),d(s(e),"directedSelfLoopCount",(function(){return e._directedSelfLoopCount})),d(s(e),"undirectedSelfLoopCount",(function(){return e._undirectedSelfLoopCount})),d(s(e),"multi",e._options.multi),d(s(e),"type",e._options.type),d(s(e),"allowSelfLoops",e._options.allowSelfLoops),d(s(e),"implementation",(function(){return"graphology"})),e}e(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(t){return this._nodes.has(""+t)},o.hasDirectedEdge=function(t,e){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.out.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(t,e){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.undirected.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(t,e){if(1===arguments.length){var n=""+t;return this._edges.has(n)}if(2===arguments.length){t=""+t,e=""+e;var i=this._nodes.get(t);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(e)||void 0!==i.undirected&&i.undirected.hasOwnProperty(e))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(t,e){if("undirected"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.directedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(t,e){if("directed"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.undirected&&n.undirected[e]||void 0;return i?i.key:void 0}},o.edge=function(t,e){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.edge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.edge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||n.undirected&&n.undirected[e]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)},o.areOutNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out},o.areInNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in},o.areUndirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"directed"!==this.type&&e in n.undirected},o.areNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)||"directed"!==this.type&&e in n.undirected},o.areInboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in||"directed"!==this.type&&e in n.undirected},o.areOutboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out||"directed"!==this.type&&e in n.undirected},o.inDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree},o.outDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree},o.directedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree},o.undirectedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegree: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree},o.inboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree),n},o.outboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.outDegree),n},o.degree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree),n},o.inDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree-e.directedLoops},o.outDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree-e.directedLoops},o.directedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree-2*e.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree-2*e.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree,i+=e.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.outDegree,i+=e.directedLoops),n-i},o.degreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree,i+=2*e.directedLoops),n-i},o.source=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.source: could not find the "'.concat(t,'" edge in the graph.'));return e.source.key},o.target=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.target: could not find the "'.concat(t,'" edge in the graph.'));return e.target.key},o.extremities=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.extremities: could not find the "'.concat(t,'" edge in the graph.'));return[e.source.key,e.target.key]},o.opposite=function(t,e){t=""+t,e=""+e;var n=this._edges.get(e);if(!n)throw new V('Graph.opposite: could not find the "'.concat(e,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(t===i)return o;if(t===o)return i;throw new V('Graph.opposite: the "'.concat(t,'" node is not attached to the "').concat(e,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(t,e){t=""+t,e=""+e;var n=this._edges.get(t);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(t,'" edge in the graph.'));return n.source.key===e||n.target.key===e},o.isUndirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isUndirected: could not find the "'.concat(t,'" edge in the graph.'));return e.undirected},o.isDirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isDirected: could not find the "'.concat(t,'" edge in the graph.'));return!e.undirected},o.isSelfLoop=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isSelfLoop: could not find the "'.concat(t,'" edge in the graph.'));return e.source===e.target},o.addNode=function(t,e){var n=function(t,e,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(e=""+e,n=n||{},t._nodes.has(e))throw new W('Graph.addNode: the "'.concat(e,'" node already exist in the graph.'));var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}(this,t,e);return n.key},o.mergeNode=function(t,e){if(e&&!c(e))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(e,'"'));t=""+t,e=e||{};var n=this._nodes.get(t);return n?(e&&(a(n.attributes,e),this.emit("nodeAttributesUpdated",{type:"merge",key:t,attributes:n.attributes,data:e})),[t,!1]):(n=new this.NodeDataClass(t,e),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:e}),[t,!0])},o.updateNode=function(t,e){if(e&&"function"!=typeof e)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(e,'"'));t=""+t;var n=this._nodes.get(t);if(n){if(e){var i=n.attributes;n.attributes=e(i),this.emit("nodeAttributesUpdated",{type:"replace",key:t,attributes:n.attributes})}return[t,!1]}var o=e?e({}):{};return n=new this.NodeDataClass(t,o),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:o}),[t,!0]},o.dropNode=function(t){t=""+t;var e,n=this._nodes.get(t);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(t,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){e=n.out[i];do{Mt(this,e),e=e.next}while(e)}for(var o in n.in){e=n.in[o];do{Mt(this,e),e=e.next}while(e)}}if("directed"!==this.type)for(var r in n.undirected){e=n.undirected[r];do{Mt(this,e),e=e.next}while(e)}this._nodes.delete(t),this.emit("nodeDropped",{key:t,attributes:n.attributes})},o.dropEdge=function(t){var e;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(e=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(t=""+t,!(e=this._edges.get(t)))throw new V('Graph.dropEdge: could not find the "'.concat(t,'" edge in the graph.'));return Mt(this,e),this},o.dropDirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t=""+t,e=""+e,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},o.dropUndirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t,e,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var t,e=this._nodes.values();!0!==(t=e.next()).done;)t.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(t){return this._attributes[t]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(t){return this._attributes.hasOwnProperty(t)},o.setAttribute=function(t,e){return this._attributes[t]=e,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.updateAttribute=function(t,e){if("function"!=typeof e)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[t];return this._attributes[t]=e(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.removeAttribute=function(t){return delete this._attributes[t],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:t}),this},o.replaceAttributes=function(t){if(!c(t))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=t,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(t){if(!c(t))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,t),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:t}),this},o.updateAttributes=function(t){if("function"!=typeof t)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=t(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=t(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:e||null})},o.updateEachEdgeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=t(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:e||null})},o.forEachAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ft(!1,!1,!1,this,t)},o.forEachAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!1,!0,this,t)},o.forEachAssymetricAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ft(!1,!0,!1,this,t)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!0,!0,this,t)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(t){if("function"!=typeof t)throw new D("Graph.forEachNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)},o.findNode=function(t){if("function"!=typeof t)throw new D("Graph.findNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return n.key},o.mapNodes=function(t){if("function"!=typeof t)throw new D("Graph.mapNode: expecting a callback.");for(var e,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(e=i.next()).done;)n=e.value,o[r++]=t(n.key,n.attributes);return o},o.someNode=function(t){if("function"!=typeof t)throw new D("Graph.someNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return!0;return!1},o.everyNode=function(t){if("function"!=typeof t)throw new D("Graph.everyNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(!t((n=e.value).key,n.attributes))return!1;return!0},o.filterNodes=function(t){if("function"!=typeof t)throw new D("Graph.filterNodes: expecting a callback.");for(var e,n,i=this._nodes.values(),o=[];!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(t,e){if("function"!=typeof t)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=e,r=this._nodes.values();!0!==(n=r.next()).done;)o=t(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var t=this._nodes.values();return new N((function(){var e=t.next();if(e.done)return e;var n=e.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var t=this,e=new Array(this._nodes.size),n=0;this._nodes.forEach((function(t,i){e[n++]=function(t,e){var n={key:t};return h(e.attributes)||(n.attributes=a({},e.attributes)),n}(i,t)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(e,o){i[n++]=function(t,e,n){var i={key:e,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===t&&n.undirected&&(i.undirected=!0),i}(t.type,o,e)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:e,edges:i}},o.import=function(t){var e,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(t instanceof i)return t.forEachNode((function(t,e){l?a.mergeNode(t,e):a.addNode(t,e)})),t.forEachEdge((function(t,e,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(t,n,i,e):a.mergeDirectedEdgeWithKey(t,n,i,e):s?a.addUndirectedEdgeWithKey(t,n,i,e):a.addDirectedEdgeWithKey(t,n,i,e)})),this;if(!c(t))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(t.attributes){if(!c(t.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(t.attributes):this.replaceAttributes(t.attributes)}if(t.nodes){if(o=t.nodes,!Array.isArray(o))throw new D("Graph.import: invalid nodes. Expecting an array.");for(e=0,n=o.length;e<n;e++){gt(r=o[e]);var h=r,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(t.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=t.edges,!Array.isArray(o))throw new D("Graph.import: invalid edges. 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t=this.tableInput.value;t&&(this.columnFunctionsMap={},t.columns.toList().forEach((t=>{Object.keys(this.supportedFunctions).forEach((e=>{const n=this.supportedFunctions[e].semTypes,i=this.supportedFunctions[e].types,o=this.supportedFunctions[e].units,r=!n.length||t.semType&&n.includes(t.semType),s=!i.length||i.includes(t.type),a=!o.length||t.meta.units&&o.includes(t.meta.units);r&&s&&a&&(this.columnFunctionsMap[t.name]||(this.columnFunctionsMap[t.name]=[]),this.columnFunctionsMap[t.name].push(e))}))})),this.regenerateColInput())}onColumnInputChanged(){const t=this.colInput.value;if(!t)return;const e=this.columnFunctionsMap[t.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:e[0],items:e,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async 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n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:t,fnNames:e,startRow:y,startCol:b,chunckSize:g-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise(((t,e)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),o?e(o):(u.set(r,i),s<m&&(m=s),a>f&&(f=a),t())}}))}await Promise.all(l),n&&u.forEach(((t,e)=>{u[e]=(t-m)/(f-m)})),i(u)}catch(t){a(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}class F{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(t,e=1e6){const n=200,i=new Uint32Array(n),o=t.distance.length,r=t.distance;for(let t=0;t<o;t++)i[Math.floor(r[t]*n)]++;let s=0,a=0;for(let t=0;t<n&&(s+=i[t],a=t,!(s>=e));t++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=t.i,d=t.j;let p=0;const m=(a+1)/n;for(let t=0;t<o;t++)r[t]<m&&(l[p]=u[t],c[p]=d[t],h[p]=r[t],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(t,e,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=t[0].length>2e4?await this.getMinimalThreshold(t,e,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach(((t,e)=>r[e].threshold=o));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:t,startIdx:u,endIdx:p,threshold:o,fnNames:e,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:t,i:e,j:o,distance:r}})=>{t?(d[n].terminate(),h(t)):(d[n].terminate(),i({i:e,j:o,distance:r,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((t,e)=>t+e.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const t of p)f.set(t.i,b),g.set(t.j,b),y.set(t.distance,b),b+=t.i.length;return{i:f,j:g,distance:y}}async calc(t,e,n,i={}){return await this.calcMultiColumn([t],[e],n,[i],[1])}async getKNN(t,e,n=15,i={}){return await this.multiColumnKNN([t],[e],n,[i],[1])}async getThresholdKNN(t,e,n=.8,i={}){return await this.multiColumnThresholdKnn([t],[e],n,[i],[1])}async multiColumnThresholdKnn(t,e,o=.8,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p=new Int32Array(t[0].length);for(const e of d)for(let n=0;n<t[0].length;++n)p[n]+=e.knnIndexes[n]?.length??0;const m={knnDistances:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e]))),knnIndexes:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e])))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)m.knnDistances[n][p[n]-1]=e.knnDistances[n][t],m.knnIndexes[n][p[n]-1]=e.knnIndexes[n][t],p[n]-=1;return m}async multiColumnSingleValueKNN(t,e,o,r=15,s,a,l=i.EUCLIDEAN){if(t.length!==o.length||t.length!==s.length||t.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=t[0].length,d=t.map((t=>t[e])),p=Math.ceil(u/this._workerCount);for(let e=0;e<this._workerCount;e++)h[e]=new Promise(((n,i)=>{const h=e*p,m=e===this._workerCount-1?u:(e+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[e].postMessage({values:t.map((t=>t.slice(h,m))),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[e].onmessage=({data:{error:t,knnDistances:o,knnIndexes:r}})=>{t?(c[e].terminate(),i(t)):(c[e].terminate(),n({knnDistances:o,knnIndexes:r}))}}));const m=await Promise.all(h),f={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const t of m)for(let e=0;e<(t.knnDistances?.length??0);++e)H(f.knnDistances,f.knnIndexes,t.knnDistances[e],t.knnIndexes[e]);return f}async multiColumnKNN(t,e,o=15,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p={knnDistances:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(99999))),knnIndexes:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(-1)))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)H(p.knnDistances[n],p.knnIndexes[n],e.knnDistances[n][t],e.knnIndexes[n][t]);return p}async getSampleDistances(t,e,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=t[0].length*(t[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:t,startIdx:d,endIdx:p,sampleLength:h,fnNames:e,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:t,distance:e}})=>{a[l].terminate(),t?u(t):c({distance:e})}}));const d=await Promise.all(u),p=d.reduce(((t,e)=>t+e.distance.length),0),m=new Float32Array(p);let f=0;for(const t of d)m.set(t.distance,f),f+=t.distance.length;return m.sort(),m}catch(t){return a?.forEach((t=>t?.terminate())),console.error(t),new Float32Array(1).fill(.5)}}async getMinimalThreshold(t,e,n=[],o,r=i.EUCLIDEAN){try{const i=t.length*(t.length-1)/2,s=await this.getSampleDistances(t,e,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(t){return console.error(t),.5}}static calcSync(t,e,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=t.length*(t.length-1)/2;for(;a<h;){const e=O(t[l])||O(t[c])?1:n(t[l],t[c]);1-e>=i&&(o.push(l),r.push(c),s.push(e)),a++,c++,c===t.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var B,D,V=n(8774);(D=B||(B={})).none="none",D.bold="bold",D.dashed="dashed";class W{get currentLineId(){return this._currentLineIdx}set currentLineId(t){t!==this._currentLineIdx&&(this._currentLineIdx=t,this.sp.render(this.ctx))}set linesToRender(t){this.updateLines(t),this.sp.render(this.ctx)}set linesVisibility(t){this.visibility=t,this.sp.render(this.ctx)}constructor(t,e,n,i,o=B.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=t,this.xAxisCol=this.sp.dataFrame.columns.byName(e),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=t=>{var e;(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(t.offsetX,t.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},this.canvas.onmousemove=t=>{var e;this.mouseOverLineId=(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)?-1:this.checkCoordsOnLine(t.offsetX,t.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},t.onEvent("d4-before-draw-scene").subscribe((t=>{this.renderLines()}))}updateLines(t){this.lines=t,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),t.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var t,e,n,i,o,r,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(t=this.lines.width)&&void 0!==t?t:1,this.ctx.strokeStyle=`rgba(${null!==(e=this.lines.color)&&void 0!==e?e:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let t=0;t<this.lines.from.length;t++)if(b.get(this.lines.from[t])&&b.get(this.lines.to[t])&&this.visibility.getBit(t)){let e=0;const n=this.sp.getMarkerSize(this.lines.from[t])/2,i=this.sp.getMarkerSize(this.lines.to[t])/2,b=this.sp.pointToScreen(this.lines.from[t]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[t]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const e=(null===(o=this.lines.colors)||void 0===o?void 0:o[t])?null===(r=this.lines.colors)||void 0===r?void 0:r[t]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[t])?null===(l=this.lines.opacities)||void 0===l?void 0:l[t]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${e},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[t])?null===(u=this.lines.widths)||void 0===u?void 0:u[t]:null!==(d=this.lines.width)&&void 0!==d?d:1}t===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[t];let A=null;if(b){e=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,e),r=this.getPointOnDistance(S,x,w,C,n,e);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[t]>this.lines.to[t]?this.findControlPoint(b,w,C,S,x,t):this.findControlPoint(b,S,x,w,C,t),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(t))&&(e||(e=this.getLineLength(w,C,S,x)),e>this.arrowWidth)){const t=b?null:this.getPointOnDistance(w,C,S,x,i,e),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==t?void 0:t.x)&&void 0!==f?f:w,null!==(g=null==t?void 0:t.y)&&void 0!==g?g:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),t===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(t){switch(this.currentLineStyle){case B.bold:t?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:t?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const t=new Path2D;t.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(t),this.ctx.closePath()}createMultiLinesIndices(){const t={};for(let e=0;e<this.lines.from.length;e++){let n=0,i=0;this.lines.from[e]<this.lines.to[e]?(n=this.lines.from[e],i=this.lines.to[e]):(n=this.lines.to[e],i=this.lines.from[e]),t[`${n}|${i}`]?(1===t[`${n}|${i}`].length&&(this.multipleLinesCounts[t[`${n}|${i}`][0]]=1,t[`${n}|${i}`].push(1)),this.multipleLinesCounts[e]=++t[`${n}|${i}`][1]):t[`${n}|${i}`]=[e]}}checkCoordsOnLine(t,e){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,t,e,i,h,u)}else o=this.calculateDistToStraightLine(t,e,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(t,e,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return t>=o-2&&t<=r+2&&e>=s-2&&e<=a+2?this.distToStraightLineSegment(t,e,n,i):null}distToStraightLineSegment(t,e,n,i){const o=(t,e,n,i)=>Math.pow(t-n,2)+Math.pow(e-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(t,e,n.x,n.y);let s=((t-n.x)*(i.x-n.x)+(e-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(t,e,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(t,e,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(e>=s-2&&e<=a+2&&n>=l-2&&n<=c+2){const t=a-s,h=c-l;return this.calculateDistToCurveInRect(e,n,i,r,o,t,h)}return null}calculateDistToCurveInRect(t,e,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new V.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(t-a),f=Math.abs(e-p),g=m+f;(!d||d>g)&&(d=g),u[r]=Math.max(m,f),c[r]=a,h[r]=p}for(let t=0;t<c.length;t++)u[t]<d&&p.setBit(t,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-t,h[n]-e);(!m||m>i)&&(m=i)}return m}getLineLength(t,e,n,i){return Math.sqrt(Math.pow(n-t,2)+Math.pow(i-e,2))}getPointOnDistance(t,e,n,i,o,r){const s=n-o*((n-t)/r),l=i-o*((i-e)/r);return new a.Point(s,l)}findControlPoint(t,e,n,i,o,r){const s=e+(i-e)/2,l=n+(o-n)/2;let c=s-e,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(t/2);return t%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(t,e,n,i,o){const r=Math.atan2(i-e,o-n)+Math.PI;t.moveTo(e-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),t.lineTo(e,n),t.lineTo(e-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}var U,j,q=n(8060),z=n(3629);async function Y(t,e,i,o,s,a,l){let c=await async function(t,e,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==a.distanceFnArgs.length||t.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:t,distanceMetrics:e,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(q.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:i}})=>{O(n)||O(i)?(d.unsubscribe(),t?h(t):c(e),setTimeout((()=>u.terminate()),100)):l&&l(n,i,e)}}))}(t,i,e,o,s,a,l);return c=c.map((t=>(0,z.S8)(t))),c}(j=U||(U={})).EUCLIDEAN="EUCLIDEAN",j.MANHATTAN="MANHATTAN";const K={[U.EUCLIDEAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[U.MANHATTAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.VECTOR_COSINE="Vector Cosine",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.EUCLIDEAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[Z.MANHATTAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[Z.VECTOR_COSINE]:function(t,e){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[Z.TANIMOTO]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[Z.LEVENSTEIN]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[Z.NEEDLEMAN_WUNSCH]:function(t,e){return`\n      let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${t+1}u>;\n      var horizontalGaps: array<u32, ${t+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${e};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${e};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${e}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${e}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.SOKAL]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[Z.COSINE]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[Z.ASYMMETRIC]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[Z.Difference]:function(t,e){return`\n    let range = suppInfo.range${e};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[Z.OneHot]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},Q={[Z.HAMMING]:t=>Math.ceil(t/30),[Z.EUCLIDEAN]:t=>Math.ceil(t/30),[Z.MANHATTAN]:t=>Math.ceil(t/30),[Z.TANIMOTO]:t=>Math.ceil(t/30),[Z.SOKAL]:t=>Math.ceil(t/30),[Z.COSINE]:t=>Math.ceil(t/30),[Z.ASYMMETRIC]:t=>Math.ceil(t/30),[Z.LEVENSTEIN]:t=>Math.ceil(t*t/60),[Z.NEEDLEMAN_WUNSCH]:t=>Math.ceil(t*t/60),[Z.MONOMER_CHEMICAL_DISTANCE]:t=>Math.ceil(t/25),[Z.Difference]:t=>1,[Z.OneHot]:t=>Math.ceil(t/40),[Z.VECTOR_COSINE]:t=>Math.ceil(t/30)},tt={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.VECTOR_COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference,Z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference,Z.VECTOR_COSINE]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var et=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function nt(t,e,n,i){return t.map(((t,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${J[t](e[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${t.length}>;\n        ${t.map(((t,e)=>`distances[${e}] = distanceScript${e}(aIndex, bIndex);`)).join("\n")}\n        ${K[i](t.length)}\n      }\n    \n    `}var it=n(1991),ot=n.n(it);let rt=0;const st="cliffsDf",at=new h.Subject,lt="Δ 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t=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((t,e)=>Math.max(t,e.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let e=0;e<p.length;e++)p[e]>t&&(t=p[e]);i.scoringMatrix=new Array(t+1).fill(null).map((()=>new Array(t+1).fill(0))),i.alphabetIndexes={};for(let t=0;t<i.scoringMatrix.length;t++)i.scoringMatrix[t][t]=1,i.alphabetIndexes[String.fromCharCode(t)]=t}const e=(t+1)*(t+1),s=new Array(t+1).fill(null).map((()=>new Float32Array(t+1)));for(let e=0;e<t+1;e++)s[e][e]=1;const a=i.alphabetIndexes;for(const t of Object.keys(a))for(const e of Object.keys(a))t!==e&&(s[t.charCodeAt(0)][e.charCodeAt(0)]=i.scoringMatrix[a[t]][a[e]]);f=2+e,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let t=0;t<s.length;t++)y.set(s[t],l),l+=s[t].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${t+1}>, ${t+1}>`}else if(e===Z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const t=p.reduce(((t,e)=>Math.min(t,e)),p[0]),e=p.reduce(((t,e)=>Math.max(t,e)),p[0]);i.range=e-t}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(t,n[e],e,r[e])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=u.map((t=>t.suppInfoStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((t=>t.dataStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((t,e)=>{f.set(t.arraySizes,e*h)}));const g=1e4,y=100,b=u.reduce(((t,e)=>t+e.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${S} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${nt(n,u.map((t=>t.maxEntryLen)),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),$=Math.floor(A/g);let R=0,k=1;console.time("GPUthreadStarts");for(let t=0;t<g;t++){const e=9999===t?A-1:(t+1)*$,n=h-2-Math.floor(Math.sqrt(-8*e+4*h*(h-1)-7)/2-.5),i=e-h*n+Math.floor((n+1)*(n+2)/2);I[t]=k,L[t]=R,N[t]=i,P[t]=n,R=n,k=i}console.timeEnd("GPUthreadStarts");const O=4e4+h*c+c+u.reduce(((t,e)=>t+e.sourceArraySize),0),H=u.reduce(((t,e)=>t+e.suppInfoSize),0),G=1e6,F=O*Uint32Array.BYTES_PER_ELEMENT;let B=F;const D=15&F;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let j=0;new Uint32Array(W,j,g).set(I),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(L),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(N),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,g).set(P),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,j,f.length).set(f),j+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,j,c).set(o),j+=c*Float32Array.BYTES_PER_ELEMENT;for(const t of u){const e=t.EncodedArrayConstructor,n=t.sourceArraySize;new e(W,j,n).set(t.flatSourceArray),j+=n*e.BYTES_PER_ELEMENT}V.unmap();const q=H*Uint32Array.BYTES_PER_ELEMENT;let z=q;const Y=15&q;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const t of u)t.suppInfoBuffer&&t.suppInfoBuffer.byteLength>0&&t.suppInfoSize>0&&(new("UINT32ARRAY"===t.suppInfoType?Uint32Array:Float32Array)(X,J,t.suppInfoBuffer.length).set(t.suppInfoBuffer),J+=t.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const et=302e4*Uint32Array.BYTES_PER_ELEMENT;let it=et;const ot=15&et;0!==ot&&(it+=16-ot);const rt=s.createBuffer({label:"results buffer",size:it,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),st=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:rt}}]}),at=s.createBuffer({label:"results out buffer",size:rt.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),lt=[],ct=[],ht=[];let ut=!1;for(;!ut;){const t=s.createCommandEncoder({label:"distance encoder"}),e=t.beginComputePass({label:"distance compute pass"});e.setPipeline(_),e.setBindGroup(0,st),e.dispatchWorkgroups(w,w),e.end(),t.copyBufferToBuffer(rt,0,at,0,at.size);const n=t.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield at.mapAsync(GPUMapMode.READ);const i=at.getMappedRange();let o=0;const r=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,G);o+=G*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,g);o+=g*Uint32Array.BYTES_PER_ELEMENT,ut=new Uint32Array(i,o,g).every((t=>1===t));const h=c.reduce(((t,e)=>t+e),0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let t=0;t<c.length;t++){const e=c[t];0!==e&&(u.set(r.subarray(t*y,t*y+e),m),d.set(a.subarray(t*y,t*y+e),m),p.set(l.subarray(t*y,t*y+e),m),m+=e)}lt.push(u),ct.push(d),ht.push(p),at.unmap()}const dt=lt.reduce(((t,e)=>t+e.length),0),pt=new Uint32Array(dt),mt=new Uint32Array(dt),ft=new Float32Array(dt);let gt=0;for(let t=0;t<lt.length;t++)pt.set(lt[t],gt),mt.set(ct[t],gt),ft.set(ht[t],gt),gt+=lt[t].length;return V.destroy(),K.destroy(),rt.destroy(),at.destroy(),{i:pt,j:mt,distance:ft}}))}([_.entries],C,[h],U.MANHATTAN,[1],[_.options??{}])}catch(t){console.error(t)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new F).calc(_.entries,h,C,_.options));const P=await async function(t,e){const n=t.distance.map(((n,i)=>{const o=Math.abs(e.get(t.i[i])-e.get(t.j[i]));return 0!=n?o/n:1/0})),i=t.distance.map((t=>1-t)),o=t.i,r=t.j,s=a.BitSet.create(e.length);return t.distance.forEach(((e,n)=>{s.set(t.i[n],!0),s.set(t.j[n],!0)})),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:s}}(L,l),$=function(t,e,n,i,o,r,s){const l=new Array(t).fill(0);for(let t=0;t!=i.length;++t)n[t]!=1/0&&(s.get(i[t])>s.get(o[t])?l[i[t]]+=n[t]:l[o[t]]+=n[t]);return a.Column.fromList("double",e,l)}(e.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);t.columns.add($);const k=P.cliffsBitSet,O=function(t){const e=t.filter((t=>t!==1/0)),n=e.reduce(((t,e)=>Math.min(t,e)),Number.MAX_VALUE);return{max:e.reduce(((t,e)=>Math.max(t,e)),n),min:n}}(P.saliVals),H=.8/(O.max-O.min),G=r.shell.getTableView(t.name),D=G.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:$.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),V=function(t,e,n,i,o,r,s,l){const c={from:new Uint32Array(e.n1.length),to:new Uint32Array(e.n1.length),opacities:new Float32Array(e.n1.length),colors:new Array(e.n1.length),widths:new Float32Array(e.n1.length)};for(let n=0;n<e.n1.length;n++)c.from[n]=e.n1[n],c.to[n]=e.n2[n],c.opacities[n]=e.saliVals[n]===1/0?1:.2+(e.saliVals[n]-s.min)*l,c.colors[n]=t.selection.get(c.from[n])&&t.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return dt.forEach(((t,e)=>{h.columns.addNewString(t).init((t=>n.get(0===e?c.from[t]:c.to[t]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(h.col(t),r),h.col(t).semType=o})),h.columns.addNewFloat(lt).init((t=>Math.abs(i.get(c.from[t])-i.get(c.to[t])))),h.columns.addNewInt(ut).init((t=>t)),h.columns.addNewFloat(ct).init((t=>e.saliVals[t])),h.columns.addNewFloat(ht).init((t=>e.simVals[t])),h.name=`${st}${rt}`,{lines:c,linesDf:h}}(t,P,e,l,p,m,O,H);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ct).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const j=new W(D,i[0],i[1],V.lines,B.none),q=b?b(V.linesDf,dt).sort([ct],[!1]):V.linesDf.plot.grid().sort([ct],[!1]);q.col(ut)&&(q.col(ut).visible=!1),t.temp[".cliffsDfGrid"]=q;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{const t=ot()(G.viewers).some((t=>t.dataFrame.name===`${st}${rt}`));w&&!t&&G.addViewer(q),G.dockManager.dock(q,"down",null,"Activity cliffs",v??.2)}));z.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:e=>{e?(D.dataFrame.setTag(pt,i[0]),t.filter.and(k),at.next(i[0])):(D.dataFrame.setTag(pt,""),t.filter.setAll(!0),at.next(""))}});D.root.prepend(s.divH([z,K.root],"cliffs_div")),at.subscribe((t=>{K.enabled=""===t||t===i[0]})),t.onRowsFiltering.subscribe((()=>{K.value&&t.filter.and(P.cliffsBitSet)}));const X=r.events.onViewerClosed.subscribe((t=>{t.args.viewer===D&&(G.dockManager.close(q.root),X.unsubscribe(),G.subs=G.subs.filter((t=>t!==X)))}));return G.subs.push(X),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let t=0;t<V.linesDf.rowCount;t++)V.lines.widths[t]=t===V.linesDf.currentRowIdx?3:1;j.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===dt[1]?V.lines.to:V.lines.from,o=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=V.linesDf.currentRowIdx;j.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(t,e,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=t/s,c=e/a,h=Math.min(l,c),u=t/h*5,d=e/h*5,p=(n<o?n:o)+s/2-u/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],V.lines.from[n]),D.dataFrame.get(i[1],V.lines.from[n]),D.dataFrame.get(i[0],V.lines.to[n]),D.dataFrame.get(i[1],V.lines.to[n]));D.zoom(a,h,c,u),K.value?t.filter.and(k):!0===K.enabled&&t.filter.setAll(!0),setTimeout((()=>{!function(t,e,n,i,o,a,l,c,h){const u=e.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:o,df:t,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{r.shell.o=e.root}),500)}(t,A,V.lines.from[o],V.lines.to[o],o,e,l,V.linesDf.get(ct,o),y);const n=D.dataFrame.getSortedOrder(G.grid.sortByColumns,G.grid.sortTypes);G.grid.scrollToCell(e.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((e=>{setTimeout((()=>(()=>{const e=a.BitSet.create(t.rowCount);for(let t=0;t<V.linesDf.rowCount;t++){const n=V.linesDf.selection.get(t);n&&(e.set(V.lines.from[t],!0),e.set(V.lines.to[t],!0)),V.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),j.linesToRender=V.lines})()),100)})),t.onSelectionChanged.subscribe((e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(S?S=!1:(t=>{t.selection.setAll(!1);for(let t=0;t<V.lines.colors.length;t++)V.lines.colors[t]="0,128,0";j.linesToRender=V.lines})(q.dataFrame))})),j.lineClicked.subscribe((e=>{if(S=!0,j.currentLineId=e.id,-1!==e.id){const n=V.linesDf.selection.clone();setTimeout((()=>{e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==e.id&&(V.linesDf.currentRowIdx=e.id,t.currentRowIdx=V.lines.from[e.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(q.sortByColumns,q.sortTypes);q.scrollToCell(dt[0],i.indexOf(e.id))}),500)}})),j.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===t.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:t,seqCol:e,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const t=s.accordion(),e=s.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(s.span([e,s.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),r.shell.o=t.root,t}(),D}var ft,gt=n(2003),yt=n(3516),bt=n(6718),vt=n(3077),wt=n(439);!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(ft||(ft={}));var Ct=n(9192);class At{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class St extends ${constructor(t={}){super({...t,enableMCL:!0});const e=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new At}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const t=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(t){super.applyInput(t),this.activitiesInput.value=this.tableInput.value.col(t.activityCol),this.similarityInput.value=t.simThreshold}}var xt,Et,Mt,Tt=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function _t(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function It(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map((t=>t.name)).join(", ")})`}n(5540),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(xt||(xt={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(Et||(Et={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(Mt||(Mt={})),Object.prototype.toString;var Lt=n(6873),Nt=n(4356),Pt=n(6717),$t=n(4870),Rt=n(3856),kt=n(6882),Ot=n(7278),Ht=n(5553),Gt=n(6642),Ft=n(3599),Bt=n(673),Dt=n(8312);class Vt extends Gt.sD{monomerLib=null;seqHelper=null;constructor(t,e){super(t,e,eo.logger),(0,bt.pj)().then((t=>{this.monomerLib=t.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Dt.Q)().then((t=>{this.seqHelper=t,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var Wt=n(4139);const Ut=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class jt extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(t){this.seqHandler.column.set(this.rowIdx,t)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===wt.YI.DNA}isRna(){return this.seqHandler.alphabet===wt.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===wt.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(t,e){if(null==e.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=e.column.dataFrame.cell(t,e.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=t,this.seqHandler=e}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const t=(0,Ot.qp)(this.helm),e=[],n=/\(|\)/;for(let i=0;i<t.length;i++){const o=t.getOriginal(i),r=o.split(n).filter((t=>!!t));3===r.length?(e.push(r[0]),e.push(r[1]),e.push(r[2])):e.push(o)}return new Ot.Mu(e,this.seqHandler.defaultGapOriginal)}}const qt=gt.zS;function zt(t){const e=!ot().enumerate(t).some((([e,n])=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";for(const[e,o]of ot().enumerate(t)){let r=e;o<t.length&&(r+=`${e?"":"-"}${i}`),n.push(r)}return[n,e]}class Yt extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=eo.seqHelper}getRendererBack(t){const[e,n,i]=(0,Gt.BG)(t);if(n.meta.units!==gt.Hi.CUSTOM)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(e,n)),o}onClick(t,e){if(t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate(),t.cell.column.meta.units===gt.Hi.CUSTOM){const n=this.getRendererBack(t);n?.onClick(t,e)}}onMouseEnter(t,e){const n=this.getRendererBack(t);n?.onMouseEnter(t,e),this.hasMouseOver=!0}onMouseMove(t,e){const n=this.getRendererBack(t);n?.onMouseMove(t,e)}onMouseLeave(t,e){if((0,Ht.WN)(t,null),t?.grid){const e=t.grid.onEvent("d4-grid-show-tooltip").subscribe((t=>{e.unsubscribe(),this.hasMouseOver&&t.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(t,e){const n=this.getRendererBack(t);n?.onDoubleClick(t,e)}onKeyDown(t,e){const n=this.getRendererBack(t);n?.onKeyDown(t,e)}onKeyPress(t,e){const n=this.getRendererBack(t);n?.onKeyPress(t,e)}renderInt(t,e,n,i,o,r,s){const[a,l,c]=(0,Gt.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(eo.properties?eo.properties.maxMonomerLength:4)??50;if(Rt.gp.maxMonomerLength in l.tags){const t=parseInt(l.getTag(Rt.gp.maxMonomerLength));d=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in h){const t=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(t)&&t?t:50}let p=c.rendererBack;p||(p=c.rendererBack=new kt.Jy(a,l,eo.logger,d,(()=>{const{font:t,fontWidth:e}=kt.Jy.getFontSettings(l);return{font:t,fontCharWidth:e,separatorWidth:u.isMsa()?8:0,monomerToShort:qt}})),l.temp[".mm.cellRenderer.settingsChanged"],Bt.s.true,p.init().then((()=>{}))),p.render(t,e,n,i,o,r,s)}render(t,e,n,i,o,r,s){if(r.cell.column?.meta?.units!==gt.Hi.CUSTOM)this.renderInt(t,e,n,i,o,r,s);else{const a=this.getRendererBack(r);a?.render(t,e,n,i,o,r,s)}}}class Kt extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[gt.gp.separator],u=this.tableCol.meta.units;i=(0,kt.U0)(l,t,e,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ut.notationProvider]?.separatorSplitter??(0,Ot.Iv)(u,h),f=m(d),g=m(p),y=ot().count(0).take(f.length).map((t=>f.getCanonical(t))).toArray(),b=ot().count(0).take(g.length).map((t=>g.getCanonical(t))).toArray(),v=this.tableCol.getTag(gt.gp.alphabet);Xt(t,e,n,i,o,y,b,v===gt.YI.RNA||v===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new Kt(e,n)),o}}class Zt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Wt.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,o,r,s){Kt.getOrCreate(r).render(t,e,n,i,o,r,s)}}function Xt(t,e,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const t=function(t,e){let n=0,i=0;const o=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)o[t]===r[t]&&n++;const s=o.length-r.length;for(let t=o.length-1;t>s;t--)o[t]===r[t-s]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill(wt.b9[gt.Hi.FASTA]);function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(ot()(e).toArray()):t=l(ot()(t).toArray()),{subParts1:t,subParts2:e}}(r,s);r=t.subParts1,s=t.subParts2}const u=t.measureText(zt(r).join("")),d=t.measureText(zt(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,t.canvas.width=p+4*r.length);let m=Math.max(e,e+(i-(p+4*r.length))/2)+5;const f=Math.max(n,n+(o-28)/2);t.save();try{t.beginPath(),t.rect(e,n,c?p+4*r.length:i,o),t.clip(),t.font="12px monospace",t.textBaseline="top";const u=7;for(let e=0;e<r.length;e++){const n=r[e],c=s[e];let d=kt.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=kt.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Rt.oZ)(t,n,m,f-u,i,o,{color:d,pivot:0,left:!0}),p=(0,Rt.oZ)(t,c,m,f+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[e]=Jt(n,c,d,r,f,u,o))}else m=(0,Rt.oZ)(t,n,m,f,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{t.restore()}}function Jt(t,e,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(zt([t]).join("")).width,h=l.measureText(zt([e]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Rt.oZ)(l,t,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,Rt.oZ)(l,e,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Qt,te=n(8070),ee=n(4326);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(Qt||(Qt={}));const ne=new class{constructor(){this.regionTypes=[Qt.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ee.fH.Entropy,this.filterSource=ee.Fo.filterSource}};var ie=n(7602),oe=n(250);const re=Qt;var se,ae;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(se||(se={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(ae||(ae={}));const le=ne;class ce extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ae.skipEmptyPositions,le.skipEmptyPositions,{category:se.DATA}),this.regionTypes=this.stringList(ae.regionTypes,le.regionTypes,{category:se.DATA,choices:Object.values(re).filter((t=>t!=re.Unknown))}),this.chains=this.stringList(ae.chains,le.chains,{category:se.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ae.fitWidth,le.fitWidth,{category:se.LAYOUT}),this.positionWidth=this.float(ae.positionWidth,le.positionWidth,{category:se.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ae.positionHeight,le.positionHeight,{category:se.LAYOUT,choices:Object.keys(ee.fH)}),this.filterSource=this.string(ae.filterSource,le.filterSource,{category:se.BEHAVIOR,choices:Object.values(ee.lT)}),this.viewSyncer=new ie.g(eo.logger)}static viewerCounter=-1;viewerId=++ce.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=`${this.viewerToLog()}.detach()`,e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),e())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case ae.regionTypes:case ae.chains:this.setData(this.regions)}switch(t.name){case ae.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ae.fitWidth:case ae.positionWidth:this.calcSize();break;case ae.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ae.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){const e=`${this.viewerToLog()}.setData()`;eo.logger.debug(`${e}, in, regions.length = ${t.length}`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(t){eo.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){eo.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<n.length;t++)for(const o of this.chains){const r=e.find((e=>e.order==n[t]&&e.chain==o));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,o,e]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let t=0;t<n.length;++t)this.logos[t]={};for(const[t,e,n]of o)this.logos[t][e]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(ee.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),eo.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){eo.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let n=0;n<this.logos.length;n++){for(const e of this.chains)this.logos[n][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[n][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,n=13,i=9,o=(this.root.clientWidth-t-(this.logos.length-1)*i-n)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const n=this.logos[t][e];n.setOptions({[oe.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,e=this.filterSourceInput.value;this.viewSyncer.sync(`${t}`,(async()=>{if(this.filterSource!==e){this.props.getProperty(ae.filterSource).set(this,e);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const n=this.chains[e];this.logos[t][n].setOptions({[oe.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.viewerToLog()}.invalidate(${t?` <- ${t} `:""})`;this.viewSyncer.sync(`${e}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,te.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}var he=n(6625),ue=n(6863);async function de(t,e,n="Morgan",i=1,o=.6){const r=t.length,s=eo.seqHelper.getSeqHandler(t),a=Array(r);let l=1;const c=new Map,h=t.categories,u=t.getRawData();for(let e=0;e<r;e++){if(null===h[u[e]]||t.isNone(e)){a[e]=null;continue}a[e]="";const n=s.getSplitted(e);for(let t=0;t<n.length;t++){const i=n.getCanonical(t);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[e]+=c.get(i)}}let d={};if(e===ue.Z.MONOMER_CHEMICAL_DISTANCE||e===ue.Z.NEEDLEMANN_WUNSCH){const t=Array.from(c.keys()),r=await(0,bt.A7)(t,n),s={};Object.entries(r.alphabetIndexes).forEach((([t,e])=>{s[c.get(t)]=e}));const l=a.reduce(((t,e)=>Math.max(t,e?.length||0)),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},e===ue.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var pe=n(4954);function me(t){const e=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.points.forEach((n=>{const i=s.divText(t.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),i]))})),e}function fe(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);t.points.forEach(((e,i)=>{n[i]=t.activityCol.get(e)}));const i={},o=eo.seqHelper.getSeqHandler(t.seqCol),r=o.defaultBiotype,a=ye(o.getSplitted(t.points[0]),o.getSplitted(t.points[1]),r,i);return e.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),e.append(be(i)),e.append(ge("Activity delta",Math.abs(n[0]-n[1]))),e.append(ge("Cliff",t.sali)),e}function ge(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function ye(t,e,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=eo.monomerLib;return Xt(r,0,0,0,30,ot().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),ot().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),n,s,!0,i),o}function be(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function ve(t,e){const n=a.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=t.col(e[0]).meta.units,n.setTag(gt.gp.separator,t.col(e[0]).getTag(gt.gp.separator)),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}class we extends a.JsViewer{constructor(t,e){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...e?{semType:e}:{},nullable:!1}),this.name=t,this.semType=e}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>{this.gridSelect||this.render(t)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("targetColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===this.semType&&(this.targetColumn=e)}this.debouncedRender()}}debouncedRender(t=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(t),this.debounceTimer=null}),100)}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ce extends we{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ue.Z.NEEDLEMANN_WUNSCH,ue.Z.HAMMING,ue.Z.LEVENSHTEIN,ue.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,gt.gp.aligned,gt.gp.separator,gt.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(t,e){super(t,e),this.distanceMetric=this.string("distanceMetric",ue.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const t=this.dataFrame.rowCount;this.preComputeDistanceMatrix=t<=1e4,this.requiresSampling=t>1e4}}needsGapPenalties(){return this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ue.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}}const Ae={gapPenalty:1,matchScore:1,gapSymbol:wt.b9[wt.Hi.FASTA],localAlignment:!1};class Se extends Ce{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(t,e){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(t&&!this.gridSelect||e){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(t,this.idxs.length).init((t=>this.targetColumn?.get(this.idxs?.get(t)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.targetColumn.getTag(t))));const e=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;e.onCurrentRowChanged.subscribe((t=>{n&&clearTimeout(n),(e.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=e.col("indexes").get(e.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(e)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=e,this.analysisGrid.invalidate()):(this.analysisGrid=e.plot.grid(),(0,$t.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,$t.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const t=this.targetColumn.length,e=Math.min(this.limit,t-1);if(!this.knn||this.kPrevNeighbors!==e||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const t=this.distanceMetric,n=await de(this.targetColumn,t,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=e,this.knn=await(new F).getKNN(i,t,e,o)}const n=new Array(e).fill(0).map(((t,e)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][e],score:1-this.knn.knnDistances[this.targetMoleculeIdx][e]})));n.sort(((t,e)=>e.score-t.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",e+1).init((t=>n[t].idx)),this.scores=a.Column.float("score",e+1).init((t=>n[t].score))}createPropertyPanel(t){const e=s.div(),n={},i=this.molCol?.name,o=t.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(t.currentRowIdx),u=function(t,e,n={}){const i={...Ae,...n},o=t.length,r=e.length,s=Array(o+1).fill(0).map((()=>Array(r+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<o+1;n++)for(let o=1;o<r+1;o++)s[n][o]=Math.max(0,s[n-1][o-1]+(t.getCanonical(n-1)===e.getCanonical(o-1)?i.matchScore:-i.matchScore),s[n-1][o]-i.gapPenalty,s[n][o-1]-i.gapPenalty),s[n][o]>=a&&(a=s[n][o],l=[n,o]);let c=i.localAlignment?l[0]:o,h=i.localAlignment?l[1]:r,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(t.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1)}u=[...ot().count(0).take(c).map((e=>t.getCanonical(e))),...u.reverse(),...i.localAlignment?ot().count(l[0]).take(o).map((e=>t.getCanonical(e))):[]],d=[...ot().count(0).take(h).map((t=>e.getCanonical(t))),...d.reverse(),...i.localAlignment?ot().count(l[1]).take(r).map((t=>e.getCanonical(t))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new Ot.Mu(u,i.gapSymbol),seq2Splitted:new Ot.Mu(d,i.gapSymbol)}}(c,h),d=ye(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(be(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>e),!0),r.shell.o=p.root}}class xe extends Ce{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(t){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.targetColumn){await this.computeByMM();const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,e=a.Column.string(t,this.renderMolIds.length).init((t=>this.targetColumn?.get(this.renderMolIds[t])));e.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>e.setTag(t,this.targetColumn.getTag(t))));const n=a.DataFrame.fromColumns([e]);e.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]}));const i=n.plot.grid();(0,$t.Kd)(i,e.name,450,30),(0,$t.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const t=this.targetColumn.length;let e;this.requiresSampling&&t>1e4?(e=this.createRandomSample(t,1e4),this.sampledIndices=e):(e=Array.from({length:t},((t,e)=>e)),this.sampledIndices=null);const n=this.distanceMetric,i=await de(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=e.map((t=>o[t])),a=new G(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=e.length,h=(d=c,(t,e)=>d*t+e-Math.floor((t+2)*(t+1)/2)),u=function(t,e){function n(t,e){let n=null,i=null;for(const o of t){const t=e(o);(null==i||t>i)&&(n=o,i=t)}return n}const i=[(r=t-1,Math.floor(function(t){return Math.random()*t}(r)))],o=new Set;var r;for(let e=0;e<t;++e)i.includes(e)||o.add(e);for(;i.length<e;){const t=n(o.values(),(t=>Math.min.apply(Math,i.map((function(e,n){return l[h(t,e)]})))));null!=t&&(i.push(t),o.delete(t))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map((t=>e[t]))}createRandomSample(t,e){const n=[];for(let e=0;e<t;e++)this.targetColumn.isNone(e)||n.push(e);if(n.length<=e)return n;for(let t=n.length-1;t>0;t--){const e=Math.floor(Math.random()*(t+1)),i=n[t];n[t]=n[e],n[e]=i}return n.slice(0,e)}}var Ee,Me=n(5433),Te=n(3890),_e=n(1687);!function(t){t.TYPE="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t[t.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",t.RGP_LINE_START="M  RGP",t.ATOM_ALIAS_LINE_START="A  ",t.END="M  END"}(Ee||(Ee={}));class Ie{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let n=t;const i=this.isWhitespace(n)?e:e-1;for(let t=0;t<i;t++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let n=this.getAtomBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToAtomType(n),e[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[t,e,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:n}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[n]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let n=this.getBondBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToBondType(n),e[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let n=e+1;for(;!this.isWhitespace(n);)++n;return t(this.fileContent.substring(e,n))}}class Le extends Ie{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,n=e;return this.isQuote(e)?(n=this.getNextIdenticalChar(e),e++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(e,n)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((n=this.fileContent.charCodeAt(e+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(n=this.shiftIdxToAtomType(n),t(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Ne extends Le{constructor(t){super(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map,e=this.fileContent.split("\n");e.filter((t=>t.startsWith(Ee.RGP_LINE_START))).forEach((e=>{const n=this.getAtomIdxToRgpIdxList(e);for(const[e,i]of n){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,i)}}));const n=e.map(((t,e)=>{if(t.startsWith(Ee.ATOM_ALIAS_LINE_START))return e})).filter((t=>void 0!==t)),i=n.map((t=>e[t])),o=n.map((t=>e[t+1]));i.forEach(((e,n)=>{const i=parseInt(e.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(t.has(r))throw new Error(`R group ${r} is already in the map`);t.set(r,i)}));const r=this.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return t}getAtomIdxToRgpIdxList(t){const e=t.split(/\s+/).filter((t=>t)).slice(3).map((t=>parseInt(t))),n=new Array(e.length/2);for(let t=0;t<e.length;t+=2)n[t/2]=[e[t+1],e[t]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((t,e)=>{if(t.includes("R#"))return e})).filter((t=>void 0!==t))}static isValidMolfile(t){return-1!==t.indexOf(Ee.TYPE)&&-1!==t.indexOf(Ee.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<Ee.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,Ee.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+Ee.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(t,e));return t=e,e+=Ee.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class Pe extends Le{constructor(t){super(t),this.init(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map;return this.getAtomLines().forEach(((e,n)=>{const i=e.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const e=i[1].split(/\s+/).map((t=>parseInt(t)));if(e.length>2)throw new Error(`R group data ${e} has more than 2 elements`);const o=e[1];if(t.has(o))throw new Error(`R group ${o} is already in the map`);t.set(o,n)}})),t}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M  V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M  END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M  V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const n=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class $e{constructor(){}static getInstance(t){if($e.isMolfileV2K(t))return new Ne(t);if($e.isMolfileV3K(t))return new Pe(t);throw new Error("Malformed molfile")}static isMolfileV2K(t){return Ne.isValidMolfile(t)}static isMolfileV3K(t){return Pe.isValidMolfile(t)}}var Re=n(6197),ke=n(9124),Oe=n(3527);class He{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(t,e,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=t,this.id=e,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++He.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ge extends He{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(t){super(t,"*","gap")}}class Fe extends He{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(t,e){super(t,e,"ambiguous")}}class Be extends He{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(t,e,n){super(t,e,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class De extends He{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(t,e){super(t,e,"broken")}}class Ve{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(t,e,n,i,o,r,s,a){this.id=t,this.m=e,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(t,e,n){let i={};const o=e.symbol,r=e.smiles;if(e.rgroups.length>0)e.rgroups.forEach((t=>{i[t.label]=t.capGroupName}));else{if(!r){if(e.lib)return new De(t,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Ve(e.symbol,e.molfile,e.name,e.naturalAnalog,e.polymerType,e.monomerType,i),a=n.getMonomerColors(t,e.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const We={[Ft.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ft.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ft.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ft.o.CHEM]:{R:"#eeeeee"},[Ft.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Ue=/[\w()]+/,je=RegExp(String.raw`\(${Ue}(,${Ue})+\)`),qe=t=>{const e=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,e,t),e},ze=new Oe.Mi([255,255,255]),Ye=new Oe.Mi([0,0,0]),Ke=.7*(0,z.wQ)(ze);class Ze{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(t,e){this._monomers=t,this.source=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([t,e])=>0===Object.keys(e).length));for(const[t,e]of Object.entries(this._monomers))for(const[t,n]of Object.entries(e))n.lib=this}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}addMissingMonomer(t,e){let n=this._monomers[t];n||(n=this._monomers[t]={});let i=e;return e==wt._S||e===wt.b9[wt.Hi.HELM]?i="Gap":("PEPTIDE"===t&&"X"===e||"RNA"===t&&"N"===e)&&(i="Any"),n[e]={symbol:e,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ot().count(1).take(9).map((t=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${t.toString()}`}))).toArray(),smiles:"",polymerType:t,monomerType:void 0,createDate:null}}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?e[n]:null}else{eo.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}getWebEditorMonomer(t,e){const[n,i]=(0,ke.fA)(t,e),o=(0,Re.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Ft.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Ft.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===wt._S||"*"==i?s=r.wem=new Ge(n):n===Ft.o.NUCLEOTIDE&&"N"===i||n===Ft.o.AA&&"X"===i||(Ft.o.CHEM,0)||je.test(i)?s=r.wem=new Fe(n,i):r.lib||(s=r.wem=new Be(n,i,this.isEmpty)),s||(s=r.wem=Ve.fromMonomer(n,r,this))),s}getTooltip(t,e){const n=(0,Re.Y)(t),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(t,e),r=this.getMonomer(n,e);if(r){const t=r.symbol,[e,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([t],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:e,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?qe(r.molfile):r.smiles?s.divV([qe(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=wt._S){let t=r.lib?.source;t?(t.endsWith(".json")&&(t=t.substring(0,t.length-5)),t=t.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(t))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${e}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(t,e){const n=this.getMonomerColors(t,e),i=t=>{const e=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(t);if(e)return[parseInt(e[1]),parseInt(e[2]),parseInt(e[3])];const n=a.Color.fromHtml(t);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Oe.Mi([...o.map((t=>t+1))]),s=(0,z.KE)(r,ze)/((0,z.wQ)(r)*(0,z.wQ)(ze)),l=i(n.backgroundcolor),c=new Oe.Mi([...l.map((t=>t+.01))]);let h;h=(0,z.KE)(c,ze)/((0,z.wQ)(c)*(0,z.wQ)(ze))<s?l:o;let u=new Oe.Mi(h);const d=(0,z.wQ)(u);return d>Ke&&(u=(0,z.dC)(Ye,u,Ke/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(t,e){const n="default";let i=n;const o=(0,Re.Y)(t),r=this.getMonomer(o,e);let s;if(r){if(r.meta&&r.meta.colors){const t=r.meta.colors;n in t||(i="default"),s=t[i]}if(!s){const e=We[t],n=e?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const e=r.naturalAnalog;if(!s&&e)return this.getMonomerColors(t,e)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(t){const e=t.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(e)for(let t=0;t<e.length;t++)if(null!=e[t]&&/\d/.test(e[t])){i=e[t][e[t].length-1],e[t]=e[t].replace(/[0-9]/g,"");for(let n=0;n<e[t].length;n++)":"!=e[t][n]&&(o+=e[t][n]);n["R"+i]=o,o=""}return n}}var Xe=n(5488),Je={};Je.styleTagTransform=A(),Je.setAttributes=b(),Je.insert=g().bind(null,"head"),Je.domAPI=m(),Je.insertStyleElement=w(),d()(Xe.A,Je),Xe.A&&Xe.A.locals&&Xe.A.locals;class Qe extends Ze{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(t,e,n=void 0){super(t,e),this.error=n}toJSON(){const t=[];for(const e of Object.values(this._monomers))for(const n of Object.values(e))t.push({...n,lib:void 0,wem:void 0});return t}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?.[n]??null}else{eo.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}_monomerSets=null;getMonomerSet(t){const e=(0,Re.Y)(t);if(this._monomerSets||(this._monomerSets={}),!(t in this._monomerSets))for(const[t,n]of Object.entries(this._monomers[e]));return this._monomerSets[t]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((n=>{e[n]=this._monomers[t][n].molfile})),e}getMonomerSymbolsByRGroup(t,e,n){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let n=e?.rgroups.length>=t;var i;return i=$e.getInstance(e.molfile).atomTypes,i.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),n&&=!0,n})),i.map((t=>t?.symbol)))}_updateLibInt(t){const e=t.getPolymerTypes(),n=this.getPolymerTypes();e.forEach((e=>{n.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((n=>{this._monomers[e][n]&&(this._duplicateMonomers[e]??={},this._duplicateMonomers[e][n]??=[this._monomers[e][n]],this._duplicateMonomers[e][n].push(t.getMonomer(e,n))),this._monomers[e][n]=t.getMonomer(e,n)}))})),this._isEmpty=this.isEmpty&&t.isEmpty}updateLibs(t,e=!1){e&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const e of t)e.error||this._updateLibInt(e);Object.entries(this.duplicateMonomers).length>0?(0,Nt.ub)().then((t=>{this.assignDuplicatePreferences(t)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(t){let e=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(t.duplicateMonomerPreferences?.[n]?.[i]){const o=t.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find((t=>t.lib?.source===o));r?this._monomers[n][i]=r:e=!1}else e=!1;return this._duplicatesHandled=e,e}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const t={},e=this.getPolymerTypes();for(const n of e)t[n]=this.getMonomerSymbolsByType(n).length;return t}getSummaryDf(){const t=this.getPolymerTypes(),e=new Array(t.length);for(const[n,i]of ot().enumerate(t))e[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",t),a.Column.fromList(a.COLUMN_TYPE.INT,"count",e)])}getSummary(){const t=this.getPolymerTypes();return 0==t.length?"empty":t.map((t=>`${t} ${this.getMonomerSymbolsByType(t).length}`)).join("\n")}static overrideCounter=0;override(t,e){return new tn(t,`override: ${++Qe.overrideCounter}, ${e}`,this)}}class tn extends Ze{data;base;constructor(t,e,n){super(t,e),this.data=t,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(t){const e=this.base.getMonomerSymbolsByType(t);for(const n of Object.keys(this.data[t]??{}))e.includes(n)||e.push(n);return e}addMissingMonomer(t,e){return this.base.addMissingMonomer(t,e)}getMonomer(t,e){const n=this.data[t]?.[e];return n??this.base.getMonomer(t,e)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(t,e,n,i,o){this.monomerLib=t,this.symbol=e,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((t=>{const n=this.monomerLib.getMonomer(this.polymerType,t.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=t.source)throw new Error(`Monomer '${e}' found in different library.`);return n}))}catch(t){const[e,n]=(0,Ct.AP)(t);this.error=e,this.monomers=[]}}}class nn{description;placeholders;source;error;constructor(t,e,n=void 0,i=void 0){this.description=t,this.placeholders=e,this.source=n,this.error=i}updateSets(t,e=!1){e&&(this.placeholders=[]);for(const e of t)e.error||this._updateSetInt(e)}_updateSetInt(t){for(const e of t.placeholders)this.placeholders.push(e)}}var on=n(7433),rn=n.n(on),sn=n(1913),an=n.n(sn);class ln{helmMonomerSchema;validateMonomerSchema;constructor(t){this.helmMonomerSchema=t;const e=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});an()(e),this.validateMonomerSchema=e.compile(this.helmMonomerSchema)}validateFile(t,e){const n=this.parseJson(t,e);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,e):(console.warn(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(t,e){try{return JSON.parse(t)}catch(t){return console.error(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format:`,t),null}}validateJsonContent(t,e){let n=!0;const i=new Set;for(const o of t){const t=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${e} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${t}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var cn=n(8604);class hn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(t,e,n,i){let o;this.fileValidator=t,this.libHelper=e,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((t=>o=t))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),r||(r=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++hn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(t,e,n){const i=await r.dapi.files.readAsText(cn.gt),o=JSON.parse(i),s=new ln(o);return new hn(s,t,e,n)}async addLibraryFile(t,e,n=!0){try{if(await r.dapi.files.exists(cn.so+`${e}`))return void r.shell.error(`File ${e} already exists`);await this.validateAgainstHELM(t,e),await r.dapi.files.writeAsText(cn.so+`${e}`,t),await this.updateValidLibList(),await r.dapi.files.exists(cn.so+`${e}`)?r.shell.info(`Added ${e} HELM library`):r.shell.error(`Failed to add ${e} library`)}catch(t){console.error(t),r.shell.error(`Failed to add ${e} library`)}}async deleteLibraryFile(t){try{await r.dapi.files.delete(cn.so+`${t}`),await this.updateValidLibList(),r.shell.info(`Deleted ${t} library`)}catch(e){console.error(e),await r.dapi.files.exists(cn.so+`${t}`)?r.shell.error(`Failed to delete ${t} library`):r.shell.warning(`File ${t} already deleted, refresh the list`)}}async loadLibraryFromFile(t,e){let n=[];const i=new a.FileSource(t),o=await i.readAsText(e);n=JSON.parse(o);const r={},s=[];return n.forEach((t=>{const e=t.polymerType,n=t.symbol;s.includes(e)||(r[e]={},s.push(e)),r[e][n]=t})),new Qe(r,e)}async loadSetFromFile(t,e,n){let i={};const o=new a.FileSource(e),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map((([e,n])=>{const i=e,o=n.polymerType,r=n.monomerType,s=n.set;return new en(t,i,o,r,s)}));return new nn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const t=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${t}, end, not changed`);for(const t of n){if(!t.endsWith(".json")){e.push(t);continue}const n=await r.dapi.files.readAsText(cn.so+`${t}`);this.isValidHELMLibrary(n,t)||e.push(t)}const i=n.filter((t=>!e.includes(t)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((t=>!t.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),e.length>0){const t=`Invalid monomer library files in ${cn.so}, consider fixing or removing them: ${e.join(", ")}`;this.logger.warning(t)}this.logger.debug(`${t}, OUT`)})),this.logger.debug(`${t}, end`),this.filesPromise}async updateValidSetList(){const t=`${this.toLog()}.updateValidSetList()`;return eo.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{eo.logger.debug(`${t}, IN`);const e=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void eo.logger.debug(`${t}, end, not changed`);for(const t of n)t.endsWith(".json")?await r.dapi.files.readAsText(cn.Es+`${t}`):e.push(t);const i=n.filter((t=>!e.includes(t)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),eo.logger.debug(`${t}, OUT`)})),eo.logger.debug(`${t}, end`),this.filesPromise}libListHasChanged(t){const e=this.eventManager.getValidLibPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}setListHasChanged(t){const e=this.eventManager.getValidSetPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}async validateAgainstHELM(t,e){if(!this.isValidHELMLibrary(t,e))throw new Error(`File ${e} does not satisfy HELM standard`)}isValidHELMLibrary(t,e){return this.fileValidator.validateFile(t,e)}async getLibFileListAtLocation(){const t=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.so).then((t=>t.filter((t=>t.isFile)).map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.so.length)))}async getSetFileListAtLocation(){const t=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.Es).then((t=>t.map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.Es.length)))}}class un{constructor(){}static _instance;static getInstance(){return un._instance||(un._instance=new un),un._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((t=>{const e=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{t(n),e.unsubscribe()}))}))}changeValidLibPathList(t){this._libFilesUpdateSubject$.next(t)}changeValidSetPathList(t){this._setFilesUpdateSubject$.next(t)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(t,e){this._librarySelectionSubject$.next([t,e])}}class dn{logger;_monomerLib=new Qe({},"MAIN");_monomerSets=new nn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(t=1/0){return t=t===1/0?6e4:t,await Promise.race([(async()=>{const t=await this.getFileManager();return await t.filesPromise,!0})(),(async()=>(await(0,te.cb)(t),!1))()]).then((e=>{if(!e)throw new Error(`Loading monomer libraries timeout ${t} ms.`)}))}constructor(t){this.logger=t}static objCounter=-1;objId=(()=>{if(++dn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return dn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(t){this._monomerLib.assignDuplicatePreferences(t)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const t=await hn.create(this,this._eventManager,this.logger);return await t.initializedPromise,t})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(t=!1){const e=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${e}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[e],i]=await Promise.all([await this.getFileManager().then((t=>[t.getValidLibraryPaths()])),(0,Nt.ub)()]),o=e.filter((t=>{const e=!i.exclude.includes(t),n=0===i.explicit.length||i.explicit.includes(t);return e&&n}));let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map((t=>this.readLibrary(cn.so,t).catch((e=>{const n=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new Qe({},t,n)})).finally((()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))))]);this._monomerLib.updateLibs(a,t),this._initialLoadCompleted=!0}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{n.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadLibrariesPromise}async loadLibraries(t){return this.loadMonomerLib(t)}loadSetsPromise=Promise.resolve();async loadMonomerSets(t=!1){const e=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${e}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[e]]=await Promise.all([await this.getFileManager().then((t=>[t.getValidSetPaths()]))]),n=e.filter((t=>!0));let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map((e=>this.readSet(cn.Es,e).catch((t=>{const n=`Loading monomer sets from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new nn("Broken monomer set",[],e,n)})).finally((()=>{t.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))))]);this._monomerSets.updateSets(r)}catch(t){const e=`Loading monomer sets error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{t.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadSetsPromise}async readLibrary(t,e){const n=await this.getFileManager();return await n.loadLibraryFromFile(t,e)}async readSet(t,e){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,t,e)}async selectSpecifiedLibraries(t){const e=await this.getInvalidFileNames(t);if(e.length>0)throw new Error(`Cannot select libraries ${e}: no such library in the list`);const n=await(0,Nt.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((e=>!t.includes(e))),await(0,Nt.Eu)(n)}async getInvalidFileNames(t){const e=(await this.getFileManager()).getValidLibraryPaths();return t.filter((t=>!e.includes(t)))}async loadMonomerLibForTests(){await(0,Nt.Eu)(cn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let t=window.$monomerLibHelperPromise;return null==t&&(t=window.$monomerLibHelperPromise=(async()=>{const t=new dn(eo.logger);return t._eventManager=un.getInstance(),t})()),t}}var 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Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new V.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},wn={RNA:{A:new V.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new V.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new V.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:vn};async function Cn(t,e,n=0){if(!Object.keys(wn).includes(e))return null;const i=await async function(t){const e=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!e)return null;try{const n=(await e.apply({molString:t}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(t){return null}}(t);if(!i)return null;if(!wn[e])return null;const o=wn[e];let r=0,s=null;for(const[t,e]of Object.entries(o)){const o=(0,k.$1)(i,e);o>r&&o>=n&&(r=o,s=t)}return s}var An,Sn=n(857),xn={};xn.styleTagTransform=A(),xn.setAttributes=b(),xn.insert=g().bind(null,"head"),xn.domAPI=m(),xn.insertStyleElement=w(),d()(Sn.A,xn),Sn.A&&Sn.A.locals&&Sn.A.locals,function(t){t.MONOMER="Monomer",t.SYMBOL="Symbol",t.NAME="Name",t.R_GROUPS="~R-Groups",t.MONOMER_TYPE="Monomer Type",t.POLYMER_TYPE="Polymer Type",t.NATURAL_ANALOG="Natural Analog",t.AUTHOR="Author",t.CREATE_DATE="Create Date",t.ID="ID",t.META="Meta",t.SOURCE="Source"}(An||(An={}));const En={[An.MONOMER]:a.COLUMN_TYPE.STRING,[An.SYMBOL]:a.COLUMN_TYPE.STRING,[An.NAME]:a.COLUMN_TYPE.STRING,[An.R_GROUPS]:a.COLUMN_TYPE.STRING,[An.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[An.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[An.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[An.AUTHOR]:a.COLUMN_TYPE.STRING,[An.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[An.ID]:a.COLUMN_TYPE.INT,[An.META]:a.COLUMN_TYPE.STRING,[An.SOURCE]:a.COLUMN_TYPE.STRING};class Mn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(An.NAME).width=100,this.tv.grid.col(An.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=yn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(t){this.monomerLibManamger=t,this.monomerLib=t.getBioLib(),this._newMonomerForm=new Nn(t,(()=>this.activeMonomerLib),(async t=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e,this.adjustTable(),null!=t&&setTimeout((()=>{const n=e.col(An.SYMBOL).toList().indexOf(t);-1!==n&&(this.tv?.grid.scrollToCell(e.columns.byIndex(0),n),e.currentRow=e.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.instance=new Mn(t)}return this.instance}static async getNewInstance(){const t=await dn.getInstance();return await t.awaitLoaded(),await t.loadLibrariesPromise,new Mn(t)}async createNewMonomerLib(t,e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(e.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,t),await r.dapi.files.writeAsText(cn.so+t,n),await this.monomerLibManamger.loadLibraries(!1),r.shell.v=await this.getViewRoot(t)}catch(t){r.shell.error("Error creating library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(t){const e=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const t=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!t)}});function i(t){return t&&t.trim()?t.endsWith(".json")&&e.includes(t)||e.includes(t+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const e=i(n.value);if(e)r.shell.warning(e);else{try{await this.createNewMonomerLib(function(){let t=n.value;return t.endsWith(".json")||(t+=".json"),t}(),t??[])}catch(t){r.shell.error("Error creating library"),console.error(t)}o.close()}})).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(t,e=!0){const n=await this.getMonomersDf(t);return this.tv=a.TableView.create(n,e),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe((({args:t})=>{if(!t||!t.menu||!t.context||t.context.type!==a.VIEWER.GRID||!t.context.tableView||t.context.tableView.id!==(this.tv.id??"")||!t.item||!t.item.isTableCell||(t.item.tableRowIndex??-1)<0)return;const e=t.item.tableRowIndex;t.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(e))})),t.menu.item("Fix all monomers",(()=>{this.fixAllMonomers()})),this.tv.dataFrame.selection.trueCount>0?(t.menu.item("Remove Selected Monomers",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this._newMonomerForm.removeMonomers(t,this.libInput.value)})),t.menu.item("Selection To New Library",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this.createNewLibDialog(t)}))):t.menu.item("Remove Monomer",(async()=>{const t=await On(this.tv.dataFrame.rows.get(e));this._newMonomerForm.removeMonomers([t],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter((t=>t.name===Mn.VIEW_NAME)).forEach((t=>t.close()))}findActiveManagerView(){if(!this.tv)return null;const t=Array.from(r.shell.tableViews??[]).find((t=>t.id===this.tv.id));return t?r.shell.v=t:Mn.closeAllMonomerManagers(),t??null}_skipLibInputOnchange=!1;async getViewRoot(t,e=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),e&&(this.tv=this.findActiveManagerView())&&(t??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),t&&(this.libInput.value=t)}catch(t){r.shell.error("Error updating library list"),console.error(t)}finally{this._skipLibInputOnchange=!1}const e=await this.getMonomersDf(t);return this.tv.dataFrame=e,this.adjustTable(),this.tv}t??=n[0],this.tv=await this.getMonomersTableView(t,e);let i=this.tv.getRibbonPanels();i.forEach(((t,e)=>{i[e]=t.filter((t=>0!==t.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((t=>t.length>0));const o=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.iconFA("wand-magic",(()=>{this.fixAllMonomers()}),"Fix all monomers"),c=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),h=s.icons.delete((async()=>{const t=this.tv?.dataFrame?.currentRowIdx??-1,e=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(t<0&&0===e.length)return;if(e.length>0){const t=await Promise.all(e.map((t=>On(this.tv.dataFrame.rows.get(t)))));return void await this._newMonomerForm.removeMonomers(t,this.libInput.value)}const n=await On(this.tv.dataFrame.rows.get(t));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(h,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const u=s.iconFA("arrow-to-bottom",(async()=>{const t=this.libInput.value;if(!t)return r.shell.error("No library selected");let e=null;try{e=await r.dapi.files.readAsText(cn.so+t)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}if(!e)return r.shell.error(`Library ${t} is empty`);a.Utils.download(t,e,"text/plain")}),"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=Mn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:t,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const t=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=t,this.adjustTable()}catch(t){console.error(t)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(t){return this._newMonomer=await On(t),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(t??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(cn.so,t),!this.activeMonomerLib)return r.shell.error(`Library ${t} not found`),a.DataFrame.create();const e=this.activeMonomerLib.getPolymerTypes().flatMap((t=>this.activeMonomerLib.getMonomerSymbolsByType(t).map((e=>this.activeMonomerLib.getMonomer(t,e))))),n=a.DataFrame.create(e.length),i=new Set;for(const t of e)t.rgroups.forEach((t=>{t.label&&i.add(t.label)}));const o=Array.from(i);o.sort();for(const[t,e]of Object.entries(En))if(n.columns.addNew(t,e),t===An.R_GROUPS)for(const t of o)n.columns.addNew(t,a.COLUMN_TYPE.STRING);n.col(An.SYMBOL).semType="Monomer",n.col(An.SYMBOL).setTag(Rt.Mn.applyToBackground,"true");for(let t=0;t<e.length;t++){let i=$n(e[t].rgroups,e[t].smiles,e[t].molfile);i=Tn(i),e[t].rgroups=Ln(e[t].rgroups);const r=o.map((n=>{const i=e[t].rgroups.find((t=>t.label===n));return i?In(i,"capGroupSmiles"):""}));let s=null;if(e[t].createDate)try{s=Date.parse(e[t].createDate)}catch(n){console.error(`Error parsing date ${e[t].createDate}`)}n.rows.setValues(t,[i,e[t].symbol,e[t].name,JSON.stringify(e[t].rgroups??[]),...r,e[t].monomerType,e[t].polymerType,e[t].naturalAnalog,e[t].author,s,e[t].id,JSON.stringify(e[t].meta??{}),e[t].lib?.source??""]);try{s&&n.col(An.CREATE_DATE)?.set(t,s,!1)}catch(n){console.error(`Error setting date ${e[t].createDate}`)}}return n.col(An.MONOMER).semType=a.SEMTYPE.MOLECULE,o.forEach((t=>{n.col(t).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((async t=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;await this.editMonomer(n.rows.get(n.currentRowIdx))}catch(t){console.error(t)}})),n}catch(t){throw r.shell.error("Error creating monomers dataframe"),console.error(t),t}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK((async()=>{const t=this.tv?.dataFrame;let e=this.libInput.value;if(t&&e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(t.rowCount).fill(0).map(((e,n)=>On(t.rows.get(n))))),i=JSON.stringify(n.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await r.dapi.files.writeAsText(cn.so+e,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(e)}catch(t){r.shell.error("Error saving library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")})).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function Tn(t){let e=t.replaceAll(/\[R[1-9]\]/g,(t=>`[*:${t[2]}]`));return e=e.replaceAll(/\[\d\*\]/g,(t=>`[*:${t[1]}]`)),e.replaceAll(/\[\d\*\:\d\]/g,(t=>`[*:${t[1]}]`))}const _n=["alternateId","capGroupName","capGroupSMILES","label"];function In(t,e){const n=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));if(n)return t[n]}function Ln(t){return t.map((t=>{const e=function(t,e){const n={};return t.forEach((t=>{const i=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));i&&(n[t]=e[i])})),n}(_n,t),n=In(e,"capGroupSMILES"),i=In(e,"alternateId"),o=In(e,"capGroupName"),r=In(e,"label")??"R1";if(n&&i&&o||r.length<2)return e;if(i&&-1!==i.indexOf(`${r}-`)){const t=i.replace(`${r}-`,"");o||(e.capGroupName=t),n||(e.capGroupSMILES=`[*:${r.substring(1)}][${t}]`)}else o&&(n||(e.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(e.alternateId=`${r}-${o}`));return e})).sort(((t,e)=>t.label?.localeCompare(e.label??"")??0))}class Nn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(t){this._molChanged=t}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(t,e,n,i){this.monomerLibManager=t,this.getMonomerLib=e,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Hn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const t=this.validateInputs();t?r.shell.warning(t):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));t&&t.header.style.removeProperty("background-color");let e=this.molSketcher.getSmiles();if(!e)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();e=$n([],e);const n=this.findRgroupsInSmiles(e);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((t=>t[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((t=>Number.parseInt(t[0].match(/[1-9]/g)[0]))).map((t=>this.rgroupsGrid.items.find((e=>e.label===`R${t}`))??{capGroupSMILES:`[*:${t}][H]`,alternateId:`R${t}-H`,capGroupName:"H",label:`R${t}`}));this.rgroupsGrid.items=i.sort(((t,e)=>t.label?.localeCompare(e.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Cn(kn(e,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(t){console.error(t)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new bn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:t=>t?r.chem.checkSmiles(t)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:t=>t?null:"Alternate ID is required",capGroupName:t=>t?null:"Cap group name is required",label:t=>t?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new bn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const t=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=t?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(t){this.triggerMolChange=!1,this.molSketcher.setSmiles(t.smiles),this.polymerTypeInput.value=t.polymerType,this.monomerTypeInput.value=t.monomerType,this.monomerSymbolInput.value=t.symbol,this.monomerNameInput.value=t.name,this.monomerIdInput.value=t.id,this.monomerNaturalAnalogInput.value=t.naturalAnalog??null,this.rgroupsGrid.items=Ln(t.rgroups),this.metaGrid.items=Object.entries(t.meta??{}).filter((([t,e])=>"colors"!==t?.toLowerCase())).map((([t,e])=>({Property:t,Value:e}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!t.naturalAnalog&&t.polymerType&&Cn(kn(t.smiles,this.rgroupsGrid.items),t.polymerType).then((t=>{t&&(this.monomerNaturalAnalogInput.value=t)}));const e=t.meta?.colors??"";let n={};try{n=e?JSON.parse(e)?.default:{}}catch(t){console.error(t)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));if(t&&t.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const t of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==t.value||""===t.value)return`${t.caption} field is required`;let e=null;if(this.rgroupsGrid.items.length<1&&(e="At least one R-group is required"),!e)t:for(const t of this.rgroupsGrid.items)for(const[n,i]of Object.entries(t))if(!i){e=`R-group ${n} field is required for ${t.label}`;break t}return!e&&this.rgroupsGrid.hasErrors()&&(e="R-group fields contain errors"),e?(t&&t.header.style.setProperty("background-color","#ff000030"),e):null}findRgroupsInSmiles(t){return[...Array.from(t.matchAll(/\[[1-9]\*\]/g)),...Array.from(t.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const t=s.buttonsInput([this.saveButton]);return s.tooltip.bind(t,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,t],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(t){const e=$n(t.rgroups,t.smiles,t.molfile),n=r.chem.drawMolecule(e,150,150),i=s.tableFromMap({name:t.name,author:t.author,createDate:t.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(t,e,n=!0){let i=[];try{const t=await r.dapi.files.readAsText(cn.so+e);i=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const o=t.map((t=>Pn(i,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType))));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${t[n].symbol} not found in library ${e}`);const a=o.map((t=>i[t])),l=s.divV(a.map((t=>this.getMonomerInfoTable(t))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((t=>t.symbol)).join(", ")} from ${e} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${e} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((t=>!a.includes(t))),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(i,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map((t=>t.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${e} library`),u.close()})).show()}async addMonomerToLib(t,e){let n=[];try{const t=await r.dapi.files.readAsText(cn.so+e);n=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const i=Pn(n,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType)),o=this.getMonomersDataFrame()?.col(An.MONOMER)?.toList()?.findIndex((e=>e===t.smiles)),a=async()=>{try{const i=n.findIndex((e=>e.symbol===t.symbol&&e.polymerType===t.polymerType));i>=0?n[i]={...t,lib:void 0,wem:void 0}:n.push({...t,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(n,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(t.symbol),this._molChanged=!1,r.shell.info(`Monomer ${t.symbol} was successfully saved in library ${e}`)}catch(t){r.shell.error("Error saving monomer"),console.error(t)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${t.symbol}' already exists in library ${e}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const t=await On(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(t),c=`Monomer with the same structure already exists in library ${e} with different symbol (${t.symbol}).\nAre you sure you want to duplicate it?`}if(l){const t=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{t.close(),a()})).show()}else await a()}async saveMonomer(){let t=this.molSketcher.getSmiles();if(!t||!r.chem.checkSmiles(t))return void r.shell.warning("Invalid SMILES");t=$n([],t);let e=r.chem.convert(t,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);e=Rn(e);const n={};this.metaGrid.items.filter((t=>!!t.Property&&!!t.Value)).forEach((t=>{n[t.Property]=t.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:e,smiles:t,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Pn(t,e){let n=-1;for(let i=t.length-1;i>=0;i--)if(e(t[i])){n=i;break}return n}function $n(t,e,n){const i=!e||!r.chem.checkSmiles(e);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):e;return o=function(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=new RegExp(`\\[\\${t.capGroupName}:${e}\\]`,"g");n=n.replace(i,`[*:${e}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(t=>`[*:${t[1]}]`)),n}(o,t),o=Tn(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function Rn(t){const e=t.split("\n"),n=e.findIndex((t=>t.startsWith("M")&&t.includes("ISO")));if(-1!==n){const t=e[n].indexOf("ISO");e[n]=e[n].substring(0,t)+"RGP"+e[n].substring(t+3)}const i=e.findIndex((t=>t.includes("V2000")));if(-1===i)return console.error("Mol start line not found"),t;const o=Number.parseInt(e[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let t=i+1;t<i+1+o;t++){const n=e[t].indexOf("R ");if(-1===n)continue;"#"!==e[t][n+1]&&(e[t]=e[t].replace("R ","R#"));const o=e[t].trim().split(" ").map((t=>t.trim())).filter(Boolean);if(r[t-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[t-i]=s)}const s=Object.keys(r);if(-1===e.findIndex((t=>t.startsWith("M")&&t.includes("RGP")))){const t=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map((([t,e])=>`${t.toString().padStart(4," ")}${e.toString().padStart(4," ")}`)).join("")}`,n=e.findIndex((t=>t.startsWith("M")&&t.includes("END")));e.splice(n,0,t)}return s.filter((t=>!!Number.parseInt(t))).map((t=>Number.parseInt(t)+i)).forEach((t=>{const n=e[t].split(" "),i=n.findIndex((t=>"R#"===t));if(-1!==i){for(let t=i+1;t<n.length;t++)n[t]&&1==n[t].length&&(Number.parseInt(n[t])??0)>0&&(n[t]="0");e[t]=n.join(" ")}})),e.join("\n")}function kn(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=In(t,"capGroupName");n=n.replace(`[*:${e}]`,`[${i}]`)})),n}async function On(t){let e;try{e=JSON.parse(t.get(An.META)??"{}");for(const t in e)"object"==typeof e[t]&&(e[t]=JSON.stringify(e[t])),("string"!=typeof e[t]||e[t]!==a.INT_NULL.toString()&&e[t]!==a.FLOAT_NULL.toString())&&("number"!=typeof e[t]||e[t]!==a.INT_NULL&&e[t]!==a.FLOAT_NULL)||(e[t]=null)}catch(t){console.error(t)}const n=t.get(An.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=Rn(i)}catch(t){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(t)}let o=t.get(An.NATURAL_ANALOG);const s=t.get(An.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(t.get(An.R_GROUPS)??"[]"),!o&&s){const t=await Cn(kn(n,l),s);t&&(o=t)}}catch(t){l??=[]}return{symbol:t.get(An.SYMBOL),name:t.get(An.NAME),molfile:i,smiles:n,polymerType:s,monomerType:t.get(An.MONOMER_TYPE),naturalAnalog:o,id:t.get(An.ID),rgroups:l,meta:e,author:t.get(An.AUTHOR),createDate:t.get(An.CREATE_DATE)}}class Hn{_colors;_colorInputs;constructor(t){this._colors=t,this._colorInputs={line:s.input.color("Line",{value:t.line,onValueChanged:t=>this._colors.line=t}),background:s.input.color("Background",{value:t.background,onValueChanged:t=>this._colors.background=t}),text:s.input.color("Text",{value:t.text,onValueChanged:t=>this._colors.text=t})}}get colors(){return this._colors}set colors(t){const e={line:a.Color.toHtml(a.Color.fromHtml(t.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(t.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(t.text??"#000000"))};this._colors=e;for(const t in this._colorInputs)this._colorInputs[t].value=e[t]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(t){this._selected=t,this.root.style.border=t?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(t){this.monomer=t}render(){s.empty(this.root);const t=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(t);const e=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(e),s.tooltip.bind(e,this.monomer.name),this.monomer.lib?.source){const t=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(t),s.tooltip.bind(t,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(t,e,n,i){this.monomerSymbol=t,this.monomers=e,this.monomerCards=e.map((t=>new Gn(t)));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(t,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,t),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach((t=>{t.root.onclick=()=>{this.monomerCards.forEach((t=>t.selected=!1)),t.selected=!0,i(t.monomer)},n&&t.monomer===n&&(t.selected=!0),o.appendChild(t.root)}))}render(){this.monomerCards.forEach((t=>t.render()))}}class Bn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Bn._instance||(Bn._instance=new Bn,await Bn._instance.refresh(),(await dn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Bn._instance.refresh()))),Bn._instance.refresh(),Bn._instance}async refresh(){this.settings=await(0,Nt.ub)();const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.monomers=t.duplicateMonomers,this.monomerCardRows=[];for(const e in this.monomers)for(const n in this.monomers[e]){const i=this.settings.duplicateMonomerPreferences?.[e]?.[n]??null,o=i?this.monomers[e][n].find((t=>t.lib?.source===i))??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[e][n],o,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][n]=i.lib.source,await(0,Nt.Eu)(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),t.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(t=>(this.monomerCardRows[t].render(),this.monomerCardRows[t].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>t(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const t=t=>{this.filteredMonomerRows=this.monomerCardRows.filter((e=>e.monomerSymbol.toLowerCase().includes(t.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)))}}}constructor(){}get root(){return this._root}}async function Dn(){await jn.showDialog()}async function Vn(t=!0){return await qn.showView(t)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const t=new Wn,e=await(0,bt.pj)();return t._fileManager=await e.getFileManager(),t._widget=await t.createWidget(),t})()),Wn.instancePromise}static async reloadWidget(){const t=await Wn.getInstance();t._widget=await t.createWidget()}async createWidget(){const t=await this.getWidgetContent();return(await(0,bt.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(t)}async getWidgetContent(){const t=await Un.createControlsForm();return mn()(t).addClass("monomer-lib-controls-form"),setTimeout((()=>{t&&mn()(t)&&mn()(t).removeClass("ui-form-condensed")}),200),s.divV([t])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async t=>{const e=await t.text(),n=t.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(e,n)}catch(t){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(t,e){this.fileManager=t,this.userLibSettings=e,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([t,e])=>{this.updateLibrarySelectionStatus(e,t)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){eo.logger.debug("LibraryControlsForm.createControlsForm(), start");const[t,e]=await Promise.all([(0,bt.pj)().then((t=>t.getFileManager())),await(0,Nt.ub)()]);return new Un(t,e)._createControlsForm()}_createControlsForm(){const t=this.createLibraryControls(),e=s.wideForm(t,void 0);return mn()(e).addClass("monomer-lib-controls-form"),e}updateControlsForm(){const t=this._createControlsForm();mn()(".monomer-lib-controls-form").replaceWith(t)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((t=>this.createLibInput(t)))}createLibInput(t){const e=`${this.toLog()}.createLibInput()`;eo.logger.debug(`${e}, libFileName = '${t}', start`);const n=!this.userLibSettings.exclude.includes(t),i=s.input.bool(t,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(t,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${t}`);const o=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(t))),a=s.icons.edit((async()=>{r.shell.v=await(await Mn.getInstance()).getViewRoot(t)}),"Edit monomer library");return s.tooltip.bind(o,`Delete ${t}`),i.addOptions(a),i.addOptions(o),eo.logger.debug(`${e}, libFileName = '${t}', end`),i}async updateLibrarySelectionStatus(t,e){this.updateLibrarySettings(t,e),await(0,Nt.Eu)(this.userLibSettings);const n=await(0,bt.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(t,e){t?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((t=>t!==e)):this.userLibSettings.exclude.includes(e)||this.userLibSettings.exclude.push(e)}promptForLibraryDeletion(t){s.dialog("Warning").add(s.divText(`Delete file ${t}?`)).onOK((async()=>{try{const e=a.TaskBarProgressIndicator.create(`Deleting ${t} library`);await this.updateLibrarySelectionStatus(!1,t),await this.fileManager.deleteLibraryFile(t),e.close()}catch(e){console.error(e),r.shell.error(`Failed to delete ${t} library`)}})).showModal(!1)}}class jn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){jn._instance||(jn._instance=new jn,jn._instance.closeDialogSubject$.subscribe((()=>{jn._instance.dialog=void 0}))),jn._instance.dialog||(jn._instance.dialog=await jn._instance.getDialog()),jn._instance.dialog.show()}async getDialog(){const t=un.getInstance(),e=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});mn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>t.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class qn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(t=!0){const e=un.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),o=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach((t=>t.unsubscribe())),this._view.detach(),this._view.close()}catch(t){}return this._view=a.View.fromRoot(l),this._view.name=qn.viewName,t&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const t=Array.from(l.children).filter((t=>t.classList.contains("ui-box")));if(2!==t.length)return;const[e,n]=t,i=e.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;e.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`}),100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe((()=>{try{const t=qn._instance;t&&t._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===t._view.id&&t._duplicateManager?.refresh()}catch(t){console.error(t)}})))})),this._view}static async showView(t=!0){return qn._instance||(qn._instance=new qn),qn._instance._duplicateManager||(qn._instance._duplicateManager=await Bn.getInstance()),qn._instance.libManager||(qn._instance.libManager=await dn.getInstance()),t&&qn._instance._view&&Array.from(r.shell.views).find((t=>t.id&&t.id===qn._instance._view.id))?(r.shell.v=qn._instance._view,await qn._instance._duplicateManager.refresh(),qn._instance._view):(qn.closeExistingViews(),qn._instance.getView(t))}static closeExistingViews(){Array.from(r.shell.views).filter((t=>t.name===qn.viewName)).forEach((t=>t.close()))}async mergeSelectedLibs(){const t="Library with this name already exists",e=await dn.getInstance();if(await e.awaitLoaded(),await e.loadLibrariesPromise,!e.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=e.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const e=h(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!e&&e!==t),i.getButton("Save")?.classList?.toggle("d4-disabled",!!e)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let t=o.value;return t.endsWith(".json")||(t+=".json"),t}function h(e){return e&&e.trim()?e.endsWith(".json")&&l.includes(e)||l.includes(e+".json")?t:null:"Library name cannot be empty"}o.addValidator(h),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const t=c(),e=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(e,t,!1);const n=await(0,Nt.ub)();n.exclude=l,await(0,Nt.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(e){r.shell.error(`Failed to save library ${t}. see console for details.`),console.error(e)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var zn,Yn=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};class Kn{_setBreadcrumbsInViewName(){var t,e;const n=["Home","Demo",...(null!==(t=this._path)&&void 0!==t?t:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((t=>Yn(this,void 0,void 0,(function*(){const e=t[t.length-1];if(e===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===e?n:n.items.find((t=>t.text===e))})))),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const t=s.iconFA("home",(()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));t.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(t)}const t=null===(e=r.shell.v.ribbonMenu.root.parentElement)||void 0===e?void 0:e.getElementsByClassName("d4-ribbon-name")[0];t&&(t.textContent="",t.appendChild(i.root))}}constructor(t,e,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Yn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Kn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var t;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(t=this._path)&&void 0!==t?t:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Yn(this,void 0,void 0,(function*(){var t,e;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(t){console.error(t)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,te.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yn(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Yn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){return Yn(this,void 0,void 0,(function*(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Yn(this,void 0,void 0,(function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Kn.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Yn(this,void 0,void 0,(function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Kn.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(zn||(zn={}));var Zn=n(966),Xn=n(608),Jn=n(1619);class Qn{urlParams;funcName;options;df;view;constructor(t,e,n={}){this.urlParams=t,this.funcName=e,this.options=n}async init(t){this.df=t,await this.buildView()}async buildView(){const t=ot()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${eo.name}.${this.funcName}?${t}`;const e={...this.options,sequenceColumnName:"sequence"};for(const[t,n]of this.urlParams.entries())switch(t){case oe.n5.fixWidth:case oe.n5.fitArea:e[t]=["1","on","true"].includes(n.toLowerCase());break;default:e[t]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ti{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const t=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:t,filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ei=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};class ni extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){t.save();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Rt.Mn.applyToBackground);t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=r.cell.value;if(!a||a==wt._S)return;let l=kt.S$,c="rgb(255, 255, 255)";if(this.monomerLib){const t=this.tableCol.getTag(wt.gp.alphabet),e=t===gt.YI.RNA||t===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA;if(s){const t=this.monomerLib.getMonomerColors(e,a);l=t?.textcolor??l,c=t?.backgroundcolor??c}else l=this.monomerLib.getMonomerTextColor(e,a)}const h=Math.max(2,Math.floor(.15*i));s&&(t.fillStyle=c,t.fillRect(e,n,i,o)),t.fillStyle=l,t.fillText((0,gt.zS)(a,h),e+i/2,n+o/2,i)}finally{t.restore()}}onMouseMove(t,e){if(t.grid.dart!=this.gridCol?.grid.dart||t.gridColumn.dart!=this.gridCol?.dart||!t.tableColumn||!t.isTableCell)return!1;const n=t.tableColumn.getTag(wt.gp.alphabet),i=t.cell.value,o=t.grid.canvas.getBoundingClientRect(),r=t.bounds.right+o.left-4,a=t.bounds.bottom+o.top-4;if(i==wt._S)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===gt.YI.RNA||n===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA,c=this.monomerLib.getTooltip(l,i);return s.tooltip.show(c,r,a),!0}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new ni(e,n)),o}}class ii extends a.GridCellRenderer{get name(){return Wt.uF.MONOMER}get cellType(){return Wt.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,n,i,o,r,s){ni.getOrCreate(r).render(t,e,n,i,o,r,s)}onMouseMove(t,e){ni.getOrCreate(t).onMouseMove(t,e)}}class oi{constructor(t,e,n=""){this.target=t,this.debugEnabled=e,this.prefix=n}error(t,e,n){return this.target.error(this.prefix+t,e,n)}warning(t,e){return this.target.warning(this.prefix+t,e)}info(t,e){return this.target.info(this.prefix+t,e)}debug(t,e){if(this.debugEnabled)return this.target.debug(this.prefix+t,e)}}class ri extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const t=super.get("FontSize");return t&&!isNaN(t)?Number.parseInt(t):12}set fontSize(t){super.set("FontSize",t),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const t=super.get("MaxMonomerLength");return"long"===t?null:parseInt(t)}set maxMonomerLength(t){const e=null===t?"long":t.toString();super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t))}}class si extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(t){this._properties=t}_initialized=!1;get initialized(){return this._initialized}constructor(t={debug:!1}){super(),super._logger=new oi(super.logger,t.debug)}completeInit(t,e,n,i){this._seqHelper=t,this._monomerLib=e,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(t){const[e,n]=(0,Ct.AP)(t);r.shell.error(e),this.logger.error(e,void 0,n)}}var ai=n(5999),li={};li.styleTagTransform=A(),li.setAttributes=b(),li.insert=g().bind(null,"head"),li.domAPI=m(),li.insertStyleElement=w(),d()(ai.A,li),ai.A&&ai.A.locals&&ai.A.locals;var ci=n(6307);class hi extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(t,e){super(s.divV([])),this.seqCol=t,this.seqHelper=e}async init(){const t=this.seqHelper.getSeqHandler(this.seqCol),e=eo.properties.tooltipWebLogo,n=this.seqCol.getTag(ee.gp.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function ui(t,e,n,i){const o=eo.seqHelper.getSeqHandler(t);let r=null,s=null;for(let t=0;t<o.posList.length;++t)o.posList[t]==e&&(r=t),o.posList[t]==n&&(s=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${n??""})`;return o.getRegion(r,s,a)}const di={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(gt.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class pi{urlParams;funcName;view;data;constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??di;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(gt.gp.positionNames,this.data.positionNames),this.data.regions&&e.setTag(gt.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${eo.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class mi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(t,e){this.call=t,this.seqHelper=e;const n=t=>this.call.inputParams[t].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const t in this.call.inputParams)s.tooltip.bind(this.inputs[t].captionLabel,n(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&this.seqHelper.getSeqHandler(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?this.seqHelper.getSeqHandler(t):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),o=document.createElement("option");e.text=o.text=t,e.value=o.value=t,n.options.add(e),i.options.add(o)}n.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(gt.gp.regions):null,n=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const t of n){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const o=t.options[i],r=JSON.parse(o.value);r&&e===r.start&&n===r.end&&(t.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=e?`${n.name}(${e.name}): ${e.start}-${e.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(t).onOK((()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{eo.handleErrorUI(t)}))})).show()}widget(){const t=s.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=s.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{eo.handleErrorUI(t)}))}));return a.Widget.fromRoot(s.divV([t,s.div(e)]))}}var fi=n(8754);async function gi(t,e,n,i,o){const r=await async function(t,e,n,i,o){const r=(0,vt.R)(e,o),s=o.getSeqHandler(e).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===ft.IDENTITY?function(t,e){const n=e.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=e.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<t.length?t.getOriginal(s):wt._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",e.rowCount),l=s.getRawData();for(let n=0;n<e.rowCount;++n){l[n]=0;for(let e=0;e<t.length;++e)(i[e]?i[e][n]:0)===r[e]&&++l[n];l[n]/=t.length}return s}(l,r):i===ft.SIMILARITY?await async function(t,e,n){const i=e.columns.toList();return await(0,bt.uL)(i,t,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=t.columns.getUnusedName(c.name),t.columns.add(c),c}(t,e,n,i,o);for(let t=0;t<r.length;t++)e.isNone(t)&&r.set(t,null,!1);return r}var yi=n(294),bi=n(330);const vi=OCL;var wi=n(9099);class Ci{monomerSymbol;constructor(t){this.monomerSymbol=t}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const t=this.rGroups.getAtomicIdx(1);if(null===t)return;const{x:e,y:n}=this.atoms.atomCoordinates[t];this.atoms.shift({x:-e,y:-n})}alignR2AlongX(){const t=this.rGroups.getAtomicIdx(2);if(null===t)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const e=this.atoms.atomCoordinates[t],n=e.y/e.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(t){this.rGroups.deleteBondLineWithSpecifiedRGroup(t)}shiftCoordinates(t){this.atoms.shift(t)}rotateCoordinates(t){this.atoms.rotate(t)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(t){this.rGroups.removeRGroups(t)}replaceRGroupWithAttachmentAtom(t,e){this.rGroups.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.rGroups.getAttachmentAtomIdByRGroupId(t)}shiftBonds(t){this.bonds.shift(t)}capRGroups(t){this.rGroups.capRGroups(t)}}var Ai=n(6956);class Si{atoms;bonds;constructor(t,e,n){this.atoms=e,this.bonds=n,this.rGroupIdToAtomicIndexMap=t.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(t){const e=this.rGroupIdToAtomicIndexMap.get(t);return void 0===e?null:e}removeRGroupsFromAtomBlock(t){t.forEach((t=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(t))throw new Error(`Cannot find atomic index for R group ${t}`)}));const e=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([e,n])=>t.includes(e))).map((([t,e])=>e));this.atoms.deleteAtoms(e)}removeRGroups(t){this.removeRGroupsFromAtomBlock(t),t.forEach((t=>{const e=this.replaceRGroupInBondsByDummy(t);this.rGroupBondPositionMap.set(t,e)}))}replaceRGroupInBondsByDummy(t){const e=this.rGroupIdToAtomicIndexMap.get(t);if(this.rGroupBondPositionMap.has(t))throw new Error(`R group ${t} is already handled`);const n=this.bonds.getPositionsInBonds(e+1);if(0===n.length)throw new Error(`Cannot find position for R group ${t}`);if(n.length>1)throw new Error(`More than one position for R group ${t}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(e+1),this.removeRGroupFromAtomicIdxMap(t,e),i}removeRGroupFromAtomicIdxMap(t,e){this.rGroupIdToAtomicIndexMap.delete(t);for(const[t,n]of this.rGroupIdToAtomicIndexMap)n>e&&this.rGroupIdToAtomicIndexMap.set(t,n-1)}deleteBondLineWithSpecifiedRGroup(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n}=e;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(t),this.rGroupIdToAtomicIndexMap.delete(t),this.rGroupBondPositionMap.forEach((t=>{t.bondLineIdx>n&&(t.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(t,e){const n=this.rGroupBondPositionMap.get(t);if(!n)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=e}getAttachmentAtomIdByRGroupId(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n,nodeIdx:i}=e;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(t){this.rGroupIdToAtomicIndexMap.forEach(((e,n)=>{const i=t[n-1];i===Ai.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(e,i)}))}}class xi{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(t,e){this.rawAtomLines[t]=this.rawAtomLines[t].replace("R#",e)}deleteAtoms(t){this.coordinates=this.coordinates.filter(((e,n)=>!t.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((e,n)=>!t.includes(n)))}shift(t){this.coordinates=this.coordinates.map((e=>{const n=e.x+t.x,i=e.y+t.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${t.x}, ${t.y}`);return{x:n,y:i}}))}rotate(t){this.coordinates=this.coordinates.map((e=>{const n=e.x,i=e.y,o=n*Math.cos(t)-i*Math.sin(t),r=n*Math.sin(t)+i*Math.cos(t);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${t}`);return{x:o,y:r}}))}}class Ei extends xi{constructor(t){super(),this.rawAtomLines=t.getAtomLines(),this.coordinates=this.rawAtomLines.map((t=>({x:parseFloat(t.substring(0,10)),y:parseFloat(t.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((t,e)=>{const n=this.coordinates[e];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${t.substring(20)}`}))}}class Mi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(t){this.rawBondLines=this.rawBondLines.filter(((e,n)=>!t.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((e,n)=>!t.includes(n)))}getPositionsInBonds(t){const e=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,o)=>{n===t&&e.push({bondLineIdx:i,nodeIdx:o})}))})),e}replacePositionsInBondsByDummy(t,e){void 0===e&&(e=-1),t.forEach((t=>{const{bondLineIdx:n,nodeIdx:i}=t;this.bondedAtomPairs[n][i]=e}))}removeAtomIdFromBonds(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e>t?e-1:e))))}shift(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e+t))))}}class Ti extends Mi{constructor(t){super(),this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((t=>[parseInt(t.substring(0,3)),parseInt(t.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((t,e)=>{if(t.some((t=>-1===t)))throw new Error(`Bonded pair ${t} contains -1`);return`${t[0].toString().padStart(3," ")}${t[1].toString().padStart(3," ")}${this.rawBondLines[e].substring(6)}`}))}}class _i extends Ci{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Ei(n),this.bonds=new Ti(n),this.rGroups=new Si(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends xi{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawAtomLines=t.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const t=this.molfileHandler.x,e=this.molfileHandler.y;return Array.from(t).map(((t,n)=>({x:t,y:e[n]})))}get atomLines(){const t=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,e=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(t,((t,e,n,i,o,a)=>e+r+i+s+a)).replace(e,"")}))}replaceRGroupSymbolByElement(t,e){super.replaceRGroupSymbolByElement(t,e);const n=this.rawAtomLines[t].substring(3).split(" ");n.length>7&&(this.rawAtomLines[t]=`M  ${n.slice(0,7).join(" ")}`)}}class Li extends Mi{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((t=>[t[0],t[1]]))}getBondLines(){const t=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((e,n)=>{if(e.some((t=>-1===t)))throw new Error(`Bonded pair ${e} contains -1`);return this.rawBondLines[n].replace(t,((t,n,i,o,r,s)=>`${n}${e[0]}${o}${e[1]}${s}`))}))}}class Ni extends Ci{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Ii(n),this.bonds=new Li(n),this.rGroups=new Si(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Pi{static getInstance(t,e){if($e.isMolfileV2K(t))return new _i(t,e);if($e.isMolfileV3K(t))return new Ni(t,e);throw new Error("Unsupported molfile version")}}class $i{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(t,e,n,i,o,r){this.monomerSymbol=t,this.monomerIdx=e,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$e.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,t,o)),this.molfileWrapper=Pi.getInstance(a,t),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[e]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(t,e,n){if($i.molfileV2KToV3KCache.has(t))return $i.molfileV2KToV3KCache.get(t);let i=null;try{if(i=n.get_mol(t,JSON.stringify({mergeQueryHs:!0})),i){const e=i.get_v3Kmolblock();return $i.molfileV2KToV3KCache.set(t,e),e}throw new Error(`Cannot convert ${e} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const t=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),e=this.monomerLib.getMonomer(t,this.monomerSymbol);if(!e)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return e}getCapGroupElements(t){return t.rgroups.map((t=>(t.capGroupSmiles||t.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(t){this.molfileWrapper.shiftCoordinates(t)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(t){this.molfileWrapper.removeRGroups(t)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(t,e){this.molfileWrapper.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.molfileWrapper.getAttachmentAtomByRGroupId(t)}deleteBondLineWithSpecifiedRGroup(t){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(t)}shiftBonds(t){this.molfileWrapper.shiftBonds(t)}}class Ri{rdKitModule;monomerLib;constructor(t,e,n){this.rdKitModule=e,this.monomerLib=n,this.helm=new wi.f(t)}monomerWrappers=[];helm;addMonomer(t,e,n){if(t===wt.b9[gt.Hi.HELM])return;const i=this.monomerWrappers.length,o=new $i(t,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const t=[];let e=0;return this.monomerWrappers.forEach((n=>{t.push(e),e+=n.getAtomLines().length})),t}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((t=>{const e=t.map((t=>t.monomerIdx)),n=t.map((t=>t.rGroupId)),i=e.map((t=>this.monomerWrappers[t])),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const t=[],e=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((t,e)=>{t.shiftBonds(n[e])})),this.restoreBondsBetweenMonomers();const i=new yi.Cg;for(const[n,o]of ot().enumerate(this.monomerWrappers)){const r=t.length,s=e.length;t.push(...n.getAtomLines()),e.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Ft.o.NUCLEOTIDE:Ft.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:ot().count(r).take(n.atomCount).toArray(),bonds:ot().count(s).take(n.bondCount).toArray()})}const o=t.length,r=e.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(t),this.getV3KBondBlock(e),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(t,e){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${t} ${e} 0 0 1`}getV3KAtomBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END BOND"].join("\n")}}class ki{constructor(t){this.molfileHandler=$e.getInstance(t)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(t){return{x:this.molfileHandler.x[t],y:this.molfileHandler.y[t]}}}class Oi{helmHelper;rdKitModule;monomerLib;constructor(t,e,n){this.helmHelper=t,this.rdKitModule=e,this.monomerLib=n}convertToSmiles(t){const e=t.dataFrame,n=this.getSmilesList(t),i=`smiles(${t.name})`,o=e?e.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map((t=>null===t?"":t)))}getSmilesList(t){return this.convertToMolfileV3KColumn(t).toList().map((t=>a.chem.convert(t,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(t){try{if(!t)return"";return vi.Molecule.fromMolfile(t).toMolfileV3().replace("STERAC1","STEABS")}catch(t){const[e,n]=(0,Ct.AP)(t);return eo.logger.error(e,void 0,n),""}}getMolV3000ViaOCL(t,e){const n=t.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let t=0;t<n.length;t++){i[t]=this.molV3KtoMolV3KOCL(n[t]);const e=t/n.length*100;o.update(e,`${e?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(e,i)}convertToRdKitBeautifiedMolfileColumn(t,e,n,i){const o=t.dataFrame,r=this.convertToMolfileV3KColumn(t).toList().map((t=>{if(""===t)return null;const e=n.get_mol(t);return e?(e.set_new_coords(),e.normalize_depiction(1),e.straighten_depiction(!0),e):null})),s=`molfile(${t.name})`,l=o?o.columns.getUnusedName(s):s;return e?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})))}convertToMolfileV3KColumn(t){const e=t.dataFrame,n=this.convertToMolfileV3K(t.toList()).map((t=>t.molfile)),i=(0,bi.kA)(e,`molfileV3K(${t.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(t){const e=new Array(t.length);for(let n=0;n<t.length;++n){const i=t[n];if(!i){e[n]=yi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(t){const[e,n]=(0,Ct.AP)(t);eo.logger.error(e,void 0,n),o=yi.vF.createEmpty()}e[n]=o}return e}getPolymerGraphColumn(t){const e=t.toList(),n=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",n)}getPolymerMolfile(t){const e=this.helmHelper.removeGaps(t),n=e.resHelm,i=new Map;for(const[t,n]of e.monomerMap?.entries()??[])i.set(n,t);const o=this.helmHelper.getMolfiles([n])[0],r=new ki(o),s=new Ri(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach(((t,e)=>{const n=r.getMonomerShifts(e);s.addMonomer(t,e,n)}));const a=s.compileToMolfile(),l=new yi.Cg;for(const[t,e]of a.monomers.entries()){const n=i.get(t);l.set(n,e)}return new yi.vF(a.molfile,l)}}class Hi{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(t,e){if(this.seqHelper=e,t.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${a.TYPE.STRING}'.`);this._column=t;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ut.notationProvider]??null);const i=this.isFasta()?wt.b9[gt.Hi.FASTA]:this.isSeparator()?wt.b9[gt.Hi.SEPARATOR]:this.isHelm()?wt.b9[gt.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??wt.b9[gt.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(gt.gp.aligned)||!this.column.tags.has(gt.gp.alphabet)||!this.column.tags.has(gt.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===gt.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag(gt.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,e)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(gt.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(gt.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${gt.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||t.temp.seqHandlerRefined||(this.refineSeparatorNotation(),t.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const t=((t,e,n)=>{const i={};let o=!0,r=null;for(const e of t){const t=e?n(e):[];if(null===r?r=t.length:t.length!==r&&(o=!1),t.length>=3)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?ot().count(0).take(Math.min(100,this.column.length)).map((t=>this.column.get(t))):this.column.categories.slice(0,100)).map((t=>t?t.substring(0,500):"")).filter((t=>0!==t.length)))],0,(t=>t.split(this.separator)));let e=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const o=n[0].prepare({col:this.column,stats:t,separator:this.separator}),r=(await o.call()).getOutputParamValue();e||=r}catch(t){console.error(t)}e&&(delete this.column.temp[Ut.seqHandler],this.column.fireValuesChanged())}static setTags(t){const e=t.column.meta.units;if([gt.Hi.FASTA,gt.Hi.SEPARATOR].includes(e)){if(!t.column.getTag(gt.gp.alphabet)&&0===Object.keys(t.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let e=t.column.getTag(gt.gp.aligned);null===e&&(e=t.stats.sameLength?"SEQ.MSA":"SEQ",t.column.setTag(gt.gp.aligned,e));let n=t.column.getTag(gt.gp.alphabet);if(null===n&&(n=(0,Ot.pc)(t.stats.freq,gt.q7),t.column.setTag(gt.gp.alphabet,n)),n===gt.YI.UN){const e=Object.keys(t.stats.freq).length,n=Object.keys(t.stats.freq).some((t=>t.length>1));t.column.setTag(gt.gp.alphabetSize,e.toString()),t.column.setTag(gt.gp.alphabetIsMultichar,n?"true":"false")}}else if(e===gt.Hi.HELM){let e=t.column.getTag(gt.gp.alphabet);null===e&&(e=(0,Ot.p0)(t.stats.freq,gt.q7,t.defaultGapOriginal),t.column.setTag(gt.gp.alphabet,e))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const t=this.column.getTag(gt.gp.separator)??void 0;if(this.notation===gt.Hi.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag(gt.gp.aligned);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag(gt.gp.alphabet);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get defaultBiotype(){return this.alphabet===gt.YI.RNA||this.alphabet===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA}get helmCompatible(){return this.column.getTag(gt.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==gt.Hi.HELM||this.alphabet==gt.YI.UN){const t=this.column.getTag(gt.gp.alphabetSize);let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case gt.YI.PT:return 20;case gt.YI.DNA:case gt.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===gt.Hi.HELM||this.alphabet===gt.YI.UN&&"true"===this.column.getTag(gt.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(t,e){if(this.cached&&void 0===e){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let e=this._splitted[t]?this._splitted[t].deref():void 0;if(!e){const n=this.column.get(t);e=this.splitter(n),this._splitted[t]=new WeakRef(e)}return e}{const n=this.column.get(t);return this.getSplitter(e)(n)}}getMonomerAtPosition(t,e,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(t)??"")[e];return n?i===wt.b9[gt.Hi.FASTA]?wt._S:i??wt._S:i??""}const i=this.getSplitted(t);return e<0||e>=i.length?this.defaultGapOriginal:n?i.getCanonical(e):i.getOriginal(e)}getMonomersAtPosition(t,e){const n=this.column.length,i=new Array(n).fill(wt._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(t<n.length){const o=n[t];i[s]=e?o===wt.b9[gt.Hi.FASTA]?wt._S:o??wt._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);t>=0&&t<n.length&&(i[o]=e?n.getCanonical(t):n.getOriginal(t))}return i}getValue(t,e){return this.column.get(t),new jt(t,this)}getHelm(t){let e;const n=this.column.get(t);return e=this.notation===gt.Hi.HELM?n:this.notation===gt.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(gt.Hi.HELM)(n),e}_stats=null;get isCanonicalAlphabet(){const t=this.alphabet;return t===gt.YI.DNA||t===gt.YI.RNA||t===gt.YI.PT}get stats(){if(null===this._stats){const t={};let e=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(e=!1);for(let e=0;e<i.length;++e){const n=i.getCanonical(e);n in t||(t[n]=0),t[n]+=1}}this._stats={freq:t,sameLength:e}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:ot().count(0).take(this.column.length).map((t=>this.getSplitted(t).length)).reduce(((t,e)=>t>e?t:e),0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const t=this.column.getTag(gt.gp.positionNames);this._posList=t?t.split(gt.z1).map((t=>t.trim())):ot().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===gt.Hi.FASTA}isSeparator(){return this.notation===gt.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===gt.Hi.HELM}isCustom(){return this.notation===gt.Hi.CUSTOM}isRna(){return this.alphabet===gt.YI.RNA}isDna(){return this.alphabet===gt.YI.DNA}isPeptide(){return this.alphabet===gt.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||t===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return gt.Hi.FASTA;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return gt.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.Hi.HELM;if(this.units.toLowerCase().startsWith(gt.Hi.CUSTOM))return gt.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e,n,i){const o=this.column,r=t.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=t,t===gt.Hi.SEPARATOR){if(!e)throw new Error(`Notation '${gt.Hi.SEPARATOR}' requires separator value.`);l.setTag(gt.gp.separator,e)}l.setTag(a.TAGS.CELL_RENDERER,t===gt.Hi.HELM?"helm":"sequence");const c=o.getTag(gt.gp.aligned);c&&l.setTag(gt.gp.aligned,c);let h=o.getTag(gt.gp.alphabet);h||this.notation!==gt.Hi.HELM||t===gt.Hi.HELM||(h=gt.YI.UN),null!=h&&l.setTag(gt.gp.alphabet,h);let u=o.getTag(gt.gp.alphabetSize);null!=h&&u&&l.setTag(gt.gp.alphabetSize,u);const d=o.getTag(gt.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(gt.gp.alphabetIsMultichar,d),t==gt.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(gt.gp.alphabetSize,u)),l}getNewColumnFromList(t,e){return this.getNewColumn(this.notation,this.separator,t,e)}static unitsStringIsValid(t){return t=t.toLowerCase(),[gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!Hi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",e,new Array(t).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(t){let e=null;if(e=this.notationProvider?this.notationProvider.splitter:null,e)return e;if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return null===this.column.getTag(gt.gp.alphabet)||this.getAlphabetIsMultichar()?gt.J9:Ot.tm;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return(0,gt.dh)(this.separator,t);if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.qp;throw new Error(`Unexpected units ${this.units} .`)}split(t){return this.splitter(t)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ue.Z.HAMMING;switch(this.alphabet){case gt.YI.DNA:case gt.YI.RNA:case gt.YI.PT:}return ue.Z.LEVENSHTEIN}getDistanceFunction(){return ue.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(gt.gp.isHelmCompatible))return"true"===this.column.getTag(gt.gp.isHelmCompatible);const t=(await(0,bt.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),e=new Set(t),n=((0,gt.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let t=0;t<i;++t){const i=o[t];if(!(i in n)){n.add(i);const o=this.getSplitted(t);for(let t=0;t<o.length;++t){const n=o.getCanonical(t);if(!e.has(n))return this.column.setTag(gt.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(gt.gp.isHelmCompatible,"true"),!0}toFasta(t){return t===gt.Hi.FASTA}toSeparator(t){return t===gt.Hi.SEPARATOR}toHelm(t){return t===gt.Hi.HELM}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?wt.b9[gt.Hi.FASTA]:wt.b9[gt.Hi.SEPARATOR]),n||(n=this.toFasta(e)?"":this.separator);const o=t.startsWith("RNA"),r=(0,gt.qp)(t),s=[];for(let t=0;t<r.length;++t){let n=r.getOriginal(t);if(o&&(n=n.replace(yn.EK,"$1")),n===wt.b9[gt.Hi.HELM])s.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join(n)}convert(t,e){const n=this.getJoiner({notation:t,separator:e}),i=this.getNewColumn(t,e);return i.init((t=>{const e=this.getSplitted(t);return n(e)})),i}getRegion(t,e,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=t??0,r=e??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=wt.b9[this.notation];i.init((t=>{const e=this.getSplitted(t),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e.getOriginal(i):l}return s(new Ot.Mu(n,l))}));const c=t=>{const e=t.split(",").map((t=>t.trim())),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e[i]:"?"}return n.join(gt.z1)},h=this.column.getTag(gt.gp.positionNames);h&&i.setTag(gt.gp.positionNames,c(h));const u=this.column.getTag(gt.gp.positionLabels);return u&&i.setTag(gt.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(t){const e=t?t.notation:this.notation,n=t?t.separator:this.separator;let i;const o=this;switch(e){case gt.Hi.FASTA:i=function(t){return o.joinToFasta(t,o.isHelm())};break;case gt.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${e}'.`);i=function(t){return Gi(t,n,o.isHelm())};break;case gt.Hi.HELM:{const t=o.alphabet===gt.YI.DNA||o.alphabet===gt.YI.RNA,e=o.getHelmWrappers();i=function(n){return Fi(n,e,t)};break}default:throw new Error(`Unexpected notation '${e}'.`)}return i}getConverter(t,e=void 0){if(t===gt.Hi.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${gt.Hi.SEPARATOR}'.`);const n=this;if(t===gt.Hi.FASTA)return function(t){return n.convertToFasta(t)};if(t===gt.Hi.HELM)return function(t){return n.convertToHelm(t)};if(t===gt.Hi.SEPARATOR)return function(t){return n.convertToSeparator(t,e)};throw new Error}static forColumn(t,e){let n=t.temp[Ut.seqHandler];return n&&n.columnVersion===t.version||(n=t.temp[Ut.seqHandler]=new Hi(t,e)),n}joinToFasta(t,e){const n=new Array(t.length);for(let i=0;i<t.length;++i){const o=t.getOriginal(i);let r=t.getOriginal(i);e&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.FASTA]:o===yn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(t){const e=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(t):e(t);return this.joinToFasta(n,this.isHelm())}convertToSeparator(t,e){return Gi(this.isHelm()?this.splitterAsHelmNucl(t):this.splitter(t),e,this.isHelm())}convertToHelm(t){if(this.notation==gt.Hi.HELM)return t;const e=this.getHelmWrappers(),n=t.startsWith("DNA")||t.startsWith("RNA");return Fi(this.splitter(t),e,n)}splitterAsHelmNucl(t){const e=this.splitter(t),n=new Array(e.length),i=t.startsWith("DNA"),o=t.startsWith("RNA");for(let t=0;t<e.length;++t){let r=e.getOriginal(t);(i||o)&&(r=r.replace(yn.EK,"$1"),r=r===yn.q7?null:r),n[t]=r||null}return new Ot.Mu(n.filter((t=>!!t)),wt.b9[gt.Hi.HELM])}getRendererBack(t,e){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(t,e)),i}}function Gi(t,e,n){const i=new Array(t.length);for(let e=0;e<t.length;++e){const o=t.getCanonical(e);let r=t.getOriginal(e);n&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.SEPARATOR]:o===yn.q7&&(r=""),i[e]=r}return i.join(e)}function Fi(t,e,n){const[i,o,r,s]=e,a=new Array(t.length);for(let e=0;e<t.length;++e){const i=t.getCanonical(e);let s=t.getOriginal(e);i===wt._S?s=wt.b9[gt.Hi.HELM]:(n&&(s=s.replace(yn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[e]=s}return`${i}${a.join(".")}${s}`}class Bi{libHelper;rdKitModule;constructor(t,e){this.libHelper=t,this.rdKitModule=e}getSeqHandler(t){return Hi.forColumn(t,this)}getSeqMonomers(t){const e=this.getSeqHandler(t);return Object.keys(e.stats.freq)}async getHelmToMolfileConverter(t){const e=await(0,ke.b2)();return new Oi(e,this.rdKitModule,t)}helmToAtomicLevelSingle(t,e,n,i=!0){if(!t)return yi.vF.createEmpty();const o=e.convertToMolfileV3K([t])[0];if(!o||!o.molfile)return yi.vF.createEmpty();let r=null;try{let t=o.molfile;if(i){if(r=this.rdKitModule.get_mol(t),!r)return yi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),t=r.get_v3Kmolblock()}return n&&(t=e.molV3KtoMolV3KOCL(t)),new yi.vF(t,o.monomers)}catch(t){const[e,n]=(0,Ct.AP)(t);return eo.logger.error(e,void 0,n),yi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(t,e,n,i){const o=i??this.libHelper.getMonomerLib(),s=t.dataFrame,l=(0,bi.qj)(s,t.name),c=await this.getHelmToMolfileConverter(o),h=t.toList(),u=new Array(t.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<t.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,e&&!p,!d).molfile;if(d){const e=await d.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n])}if(e&&p){const e=await p.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",t.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.FASTA)throw new Error(`The column of notation '${gt.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);t.column.meta.units=gt.Hi.FASTA,Hi.setTags(t)}setUnitsToSeparatorColumn(t,e){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.SEPARATOR)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must have the separator tag.`);t.column.meta.units=gt.Hi.SEPARATOR,t.column.setTag(gt.gp.separator,e),Hi.setTags(t)}setUnitsToHelmColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${gt.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);t.column.meta.units=gt.Hi.HELM,Hi.setTags(t)}}async function Di(t){let e="";try{if(!t||!t.value)return e="No sequence provided",{errorText:e,mol:""};if(!(t.cell&&t.cell.dart&&t.cell.dataFrame&&t.cell.column))return e="Atomic level conversion requeires a sequence column",{errorText:e,mol:""};if(![gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].includes(t.cell.column.meta.units?.toLowerCase()??""))return e="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:e,mol:""};const n=(await xr()).getSeqHandler(t.cell.column);if(!n)return e="No sequence handler found",{errorText:e,mol:""};if((n.getSplitted(t.cell.rowIndex,50)?.length??100)>40)return e="Maximum number of monomers is 40",{errorText:e,mol:""};const i=a.Column.fromStrings("singleVal",[t.value]),o=a.DataFrame.fromColumns([i]);if(Object.entries(t.cell.column.tags).forEach((([t,e])=>{i.setTag(t,e)})),await No(o,i,t.cell.column.meta.units===gt.Hi.HELM,!1),o.columns.length<2)return e="No structure generated",{errorText:e,mol:""};const r=o.columns.byIndex(1).get(0);return r?{errorText:"",mol:r}:(e="No structure generated",{errorText:e,mol:""})}catch(t){eo.logger.error(t)}return e="No Structure generated",{errorText:e,mol:""}}const Vi="#333333",Wi="rgba(60, 177, 115, 0.1)",Ui="rgba(240, 240, 240, 0.5)",ji="rgba(100, 100, 100, 0.3)";class qi{constructor(t=Ki.DEFAULT_TRACK_HEIGHT,e=Ki.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=t,this.defaultHeight=t,this.minHeight=e,this.title=n}init(t){this.ctx=t}getMonomerAt(t,e,n){return null}enableTooltip(t){this.tooltipEnabled=t}setTooltipContentGenerator(t){this.tooltipContent=t}getTooltipContent(t,e){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(t)??new Map;return this.tooltipContent(t,e,n)}getPositionData(t){return null}setVisible(t){this.visible=t}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(t){this.height=Math.max(this.minHeight,t)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(t){this.title=t}getTitle(){return this.title}}class zi extends qi{constructor(t=new Map,e=Ki.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(e,Ki.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=t,this.visible=t.size>0}setHovered(t,e){this.hoveredPosition=t,this.hoveredMonomer=e}getPositionData(t){return this.data.get(t)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator(((t,e,n)=>this.createTooltipContent(t,e,n)))}createFrequencyTable(t){let e;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":e=Ft.o.NUCLEOTIDE;break;default:e=Ft.o.AA}const n=Array.from(t.values()).reduce(((t,e)=>t+e),0),i={};for(const[e,o]of t.entries())i[e]=Math.max(1,Math.round(o/n*100));const o=(0,ci.F)(i,e,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(t,e,n){const i=[];if(i.push(s.divText(`Position: ${t+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),e&&(i.push(s.divText(`Monomer: ${e}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(e)&&i.push(s.divText(`${(100*n.get(e)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const t=this.createFrequencyTable(n);i.push(t)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(t){this.monomerLib=t}setBiotype(t){this.biotype=t}getMonomerAt(t,e,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=e,r=Array.from(i.entries()).sort(((t,e)=>e[1]-t[1])),s=r.reduce(((t,[e,n])=>t+n),0),a=this.height;let l=0;for(const[t,e]of r){const n=e*a/s;if(o>=l&&o<l+n)return t;l+=n}return null}updateData(t){this.data=t,this.visible=t.size>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=e+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,t,e,n,i,o,r,s,a,h,c)}drawWebLogoColumn(t,e,n,i,o,r,s,a,l,c,h){const u=r+t-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=e+t*s,m=s-2;r+t===l&&(this.ctx.fillStyle=Wi,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=Ui,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(t,e,n,i,o,r){const s=Array.from(r.entries()).sort(((t,e)=>e[1]-t[1])),a=s.reduce(((t,[e,n])=>t+n),0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=t===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,e+1,c,n,d,u),c+=d}}drawColumnBorder(t,e,n,i){this.ctx.strokeStyle=ji,this.ctx.lineWidth=1,this.ctx.strokeRect(t+1,e,n,i)}drawLetter(t,e,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(t),a=this.getMonomerTextColor(t);this.ctx.fillStyle=s,this.ctx.fillRect(e,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(e,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(e,n,i,o),this.drawLetterText(t,e,n,i,o,a)}drawLetterSeparators(t,e,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,e+i<e+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(t,e+i),this.ctx.lineTo(t+n,e+i),this.ctx.stroke())}drawLetterText(t,e,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,e+i/2,n+o/2))}getMonomerBackgroundColor(t){if(this.monomerLib)try{const e=this.monomerLib.getMonomerColors(this.biotype,t);if(e&&e.backgroundcolor)return e.backgroundcolor}catch(t){console.warn("Error getting background color from monomerLib:",t)}return"#CCCCCC"}getMonomerTextColor(t){const e=this.getMonomerBackgroundColor(t);try{const t=a.Color.fromHtml(e),n=a.Color.getContrastColor(t);return a.Color.toHtml(n)}catch(t){return console.warn("Error calculating contrast color:",t),"#000000"}}}class Yi extends qi{constructor(t,e=Ki.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(e,Ki.MIN_TRACK_HEIGHT,i),this.data=t,this.colorScheme=n,this.visible=t.length>0}updateData(t){this.data=t,this.visible=t.length>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=t+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,e,i),l===a&&(this.ctx.fillStyle=Wi,this.ctx.fillRect(c,e,h,i)))}}drawConservationBar(t,e,n,i,o,r){if(!this.ctx)return;const s=this.data[t];this.ctx.fillStyle=Ui,this.ctx.fillRect(e+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const t=Math.round(255*s);a=`rgb(255, ${t}, ${t})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(e+2,o+r-l,n-4,l),this.ctx.strokeStyle=ji,this.ctx.lineWidth=1,this.ctx.strokeRect(e+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Vi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Ki={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Zi={BASE:Ki.DOTTED_CELL_HEIGHT+Ki.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Ki.TITLE_HEIGHT+Ki.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Ki.DEFAULT_TRACK_HEIGHT+Ki.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Ki.DEFAULT_TRACK_HEIGHT+Ki.TRACK_GAP}};class Xi{constructor(t){this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:t.x||0,y:t.y||0,width:t.width||0,height:t.height||0,windowStartPosition:t.windowStartPosition||1,positionWidth:t.positionWidth||15,totalPositions:t.totalPositions||5e3,headerHeight:t.headerHeight||Zi.BASE,sliderHeight:t.sliderHeight||Ki.SLIDER_HEIGHT,currentPosition:t.currentPosition||1,cellBackground:void 0===t.cellBackground||t.cellBackground,sliderColor:t.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:t.onPositionChange||((t,e)=>{}),onHeaderHeightChange:t.onHeaderHeightChange||(()=>{}),...t},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const t=this.config.headerHeight,e=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach((t=>{t.setVisible(!1),t.setHeight(Ki.DEFAULT_TRACK_HEIGHT)})),!(t<Zi.WITH_TITLE()||t<Zi.WITH_WEBLOGO()))if(t<Zi.WITH_BOTH()){if(e){e.setVisible(!0);const n=t-Zi.WITH_WEBLOGO();e.setHeight(Ki.DEFAULT_TRACK_HEIGHT+n)}}else{if(e&&e.setVisible(!0),n&&n.setVisible(!0),e&&t>Zi.WITH_BOTH()){const n=t-Zi.WITH_BOTH();e.setHeight(Ki.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]||t.setVisible(!1)})),t<Zi.WITH_WEBLOGO()&&e&&e.setVisible(!1),t<Zi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),e=this.getTrack("weblogo"),n=t?.isVisible()??!1,i=e?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Zi.WITH_TITLE()?(Ki.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&t&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&e&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(t,e,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:t,label:e,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,n+o/2,i+r/2))}handleTrackButtonClick(t,e){for(const n of this.trackButtons)if(t>=n.x&&t<=n.x+n.width&&e>=n.y&&e<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}snapToTrackHeight(t){let e;if("weblogo"===t)e=Zi.WITH_WEBLOGO();else{if("conservation"!==t)return;e=Zi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]=!1}))),"conservation"===t?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===t&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame((()=>this.redraw()))}resetToAutoMode(){this.userSelectedTracks=null;const t=this.tracks.size>0?Zi.WITH_BOTH():Zi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame((()=>this.redraw()))}drawColumnTitle(t,e,n,i){this.ctx&&i&&this.config.headerHeight>=Zi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(t,e,n,Ki.TITLE_HEIGHT),this.ctx.fillStyle=Vi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,t+n/2,e+Ki.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach((t=>{t instanceof zi&&t.setHovered(-1,null)})),window.requestAnimationFrame((()=>this.redraw())))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(t,e,n,i){this.dataFrame=t,this.seqColumn=e,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(t){if(!this.isValid)return;const{x:e,y:n}=this.getCoords(t),i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Zi.WITH_TITLE()?Ki.TITLE_HEIGHT:0,l=this.config.headerHeight-Ki.SLIDER_HEIGHT-Ki.DOTTED_CELL_HEIGHT,c=l-Ki.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let f=c;for(const{id:t,track:e}of d){const i=f-e.getHeight();if(n>=i&&n<f){h=t,u=n-i;break}f=i-Ki.TRACK_GAP}let g=null;if(h){const t=this.tracks.get(h);t&&(g=t.getMonomerAt(e,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==g)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=g,h)){const t=this.tracks.get(h);t instanceof zi&&(t.setHovered(r,g),window.requestAnimationFrame((()=>this.redraw())))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||g!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=g,h)){const e=this.tracks.get(h);if(e){const n=e.getTooltipContent(r,g);if(n)return void s.tooltip.show(n,t.clientX+16,t.clientY+16)}}h&&g||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame((()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(t,e,n,i,o,r,s,a){if(Object.assign(this.config,{x:t,y:e,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(t,e,n,i),this.ctx.translate(t,e),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Zi.WITH_TITLE();l&&Ki.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Ki.SLIDER_HEIGHT,h=c-Ki.DOTTED_CELL_HEIGHT,u=h-Ki.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const f=this.getTrack("conservation");f&&f.isVisible()&&p.push({id:"conservation",track:f});let g=u;for(const{track:t}of p){const e=t.getHeight(),i=g-e;t.draw(0,i,n,e,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:e}),g=i-Ki.TRACK_GAP}if(this.drawDottedCells(0,h,n,Ki.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:Ki.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const t=this.config.positionWidth,e=this.config.currentPosition-this.config.windowStartPosition;if(e>=0&&e<Math.floor(n/t)){const n=e*t+t/2;for(let t=0;t<d.length-1;t++){const e=d[t],i=d[t+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,e.y+e.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(t,e,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=e+Ki.TOP_PADDING;this.drawSlider(t,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=t+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,e,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,e),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Vi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,e,d,i))}}drawSlider(t,e,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(t,e,n,Ki.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(t+a,e,l,Ki.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(t+o-1,e-2,3,Ki.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(t){const e=this.canvas.getBoundingClientRect();return{x:t.clientX-e.left-this.config.x,y:t.clientY-e.top-this.config.y}}isInHeaderArea(t){const{x:e,y:n}=this.getCoords(t);return e>=0&&e<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(t){this.config.positionWidth=t}isInSliderArea(t){const{y:e}=this.getCoords(t),n=this.config.headerHeight-Ki.SLIDER_HEIGHT;return e>n&&e<n+Ki.SLIDER_HEIGHT}get sliderWidth(){const t=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(t,20)}isInSliderDraggableArea(t){const{x:e,y:n}=this.getCoords(t),i=this.config.headerHeight-Ki.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Ki.SLIDER_HEIGHT&&e>=a&&e<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",(t=>{this.isValid&&(this.isInSliderDraggableArea(t)?this.eventElement.style.cursor="grab":this.isInSliderArea(t)||this.isInHeaderArea(t)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")})),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(t){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return;const i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Zi.WITH_TITLE()?Ki.TITLE_HEIGHT:0,a=this.config.headerHeight-Ki.SLIDER_HEIGHT-Ki.DOTTED_CELL_HEIGHT,l=a-Ki.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:t,track:e}of u){const i=m-e.getHeight();if(n>=i&&n<m){c=t,h=n-i;break}m=i-Ki.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(e,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),t.stopPropagation(),t.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(t,e){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(t,!0);n.init((t=>i[t]===e))}catch(t){console.error("Error selecting rows:",t)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const t=this.canvas.getContext("2d");t?(this.ctx=t,this.tracks.forEach((e=>e.init(t)))):console.error("Failed to get 2D context from canvas")}addTrack(t,e){this.ctx&&e.init(this.ctx),this.tracks.set(t,e)}removeTrack(t){this.tracks.delete(t)}getTrack(t){return this.tracks.get(t)}updateTrack(t,e){const n=this.getTrack(t);n&&e(n)}get isValid(){return!!this.canvas&&!!this.ctx&&this.config.height>=Zi.WITH_TITLE()}handleMouseDown(t){if(!this.isValid)return;const{x:e}=this.getCoords(t);this.isInSliderDraggableArea(t)&&(this.state.isDragging=!0,this.state.dragStartX=e,this.handleSliderDrag(e),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation())}handleMouseWheel(t){if(this.isValid&&this.isInHeaderArea(t)){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e=t.shiftKey?Math.sign(t.deltaY):Math.sign(t.deltaX||t.deltaY),n=t.shiftKey?3:1,i=this.config.windowStartPosition+e*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(t){if(!this.state.isDragging||!this.isValid)return;const e=this.canvas.getBoundingClientRect(),n=t.clientX-e.left-this.config.x;this.handleSliderDrag(n),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}handleKeyDown(t){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===t.key||"ArrowRight"===t.key){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e="ArrowLeft"===t.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+e,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=e<0?n:Math.max(1,n-i+1))}else{if("Escape"!==t.key)return;this.config.currentPosition=-2,t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(t){if(!this.isValid)return;const e=this.sliderWidth,n=this.config.width-e,i=Math.max(0,Math.min(this.config.width,t)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-e/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(t){this.config.headerHeight=t}handleClick(t){if(!this.isValid)return;t.clientX,this.canvas.getBoundingClientRect().left,t.clientY,this.canvas.getBoundingClientRect().top;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return t.preventDefault(),void t.stopPropagation();if(n<this.config.headerHeight-Ki.SLIDER_HEIGHT&&n>=0){const t=this.config.positionWidth,n=Math.round(e/t-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(t){Object.assign(this.config,t),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(t){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Zi.BASE,WITH_TITLE:Zi.WITH_TITLE(),WITH_WEBLOGO:Zi.WITH_WEBLOGO(),WITH_BOTH:Zi.WITH_BOTH()}}}class Ji{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){Ji.conservationCache=new a.LruCache(100),Ji.webLogoCache=new a.LruCache(100),Ji.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return Ji.lastInvalidationTime}static getChunkCacheKey(t,e,n){const i=t.dataFrame;return`${i.id}_${t.name}_f${i.filter.version}_${e}_${n}`}static getConservationChunk(t,e,n,i){return Ji.conservationCache.getOrCreate(i,(()=>{const o=Ji.getWebLogoChunk(t,e,n,i),r=new Array(n-e).fill(0);for(let i=e;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=t.defaultGapOriginal;for(const[t,e]of n.entries())t&&t!==l&&(s+=e,e>a&&(a=e));r[i-e]=s>0?a/s:0}return r}))}static getWebLogoChunk(t,e,n,i){return Ji.webLogoCache.getOrCreate(i,(()=>{const i=t.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let t=e;t<n;t++)o.set(t,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=t.getSplitted(i).getOriginalRegion(e,n);if(0!==r.length)for(let t=0;t<r.length;t++){const n=r[t],i=o.get(e+t);i.set(n,(i.get(n)||0)+a)}}return o}))}static getConservationForViewport(t,e,n,i){const o=new Array(i).fill(0),r=Math.floor(e/Ji.CHUNK_SIZE)*Ji.CHUNK_SIZE,s=Math.ceil(n/Ji.CHUNK_SIZE)*Ji.CHUNK_SIZE;for(let e=r;e<s;e+=Ji.CHUNK_SIZE){const n=Math.min(e+Ji.CHUNK_SIZE,i),r=Ji.getChunkCacheKey(t.column,e,n),s=Ji.getConservationChunk(t,e,n,r);for(let t=0;t<s.length&&e+t<i;t++)o[e+t]=s[t]}return o}static getWebLogoForViewport(t,e,n,i){const o=new Map,r=Math.floor(e/Ji.CHUNK_SIZE)*Ji.CHUNK_SIZE,s=Math.ceil(n/Ji.CHUNK_SIZE)*Ji.CHUNK_SIZE;for(let e=r;e<s;e+=Ji.CHUNK_SIZE){const n=Math.min(e+Ji.CHUNK_SIZE,i),r=Ji.getChunkCacheKey(t.column,e,n),s=Ji.getWebLogoChunk(t,e,n,r);for(const[t,e]of s.entries())t<i&&o.set(t,e)}return o}}class Qi extends zi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=Ji.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=Ji.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}class to extends Yi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=Ji.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=Ji.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}const eo=new si;async function no(){return await dn.getInstance()}class io{_palette;constructor(t){this._palette=t}get(t){return this._palette[t]}}let oo=null;async function ro(){null===oo&&(oo=async function(){const t="Bio: _package.initBio()";eo.logger.debug(`${t}, start`);const e=window.performance.now(),n=await(0,Pt.j)(),i=await eo.getProperties(),o=new ri(i);eo.properties=o;const s=await dn.getInstance(),l=await(0,Nt.ub)();l.explicit&&(l.explicit=[],await(0,Nt.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();eo.logger.debug(`${t}, loading ET: ${d-e} ms`);const p=new Bi(s,n);eo.completeInit(p,c,u,n),eo.logger.debug(`${t}, end`),function(){const t=t=>{setTimeout((()=>{if(t.isDetached)return;const e=t.dataFrame;if(!e)return;const n=e.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let n=null;try{n=eo.seqHelper.getSeqHandler(i)}catch(t){continue}if(!n)continue;if(n.isHelm()||n.alphabet===gt.YI.UN)continue;const o=t.col(i.name);if(!o)continue;let s=!!t.tableView&&Array.from(t.tableView.viewers).some((t=>"Sequence Position Statistics"===t.type));if(n.isMsa()){const l=(t,e)=>Number.isNaN(t)?e:t,c=()=>l(Math.max(Number.parseInt(i.getTag(gt.gp.positionShift)??"0"),0),0)+1,u=()=>l(Number.parseInt(i.getTag(gt.gp.selectedPosition)??"-2"),-2),d=()=>kt.Jy.getFontSettings(i).fontWidth;let p=0,m=0;const f=i.categories;for(let t=0;t<f.length;t++){const e=f[t];e&&e.length>m&&(m=e.length,p=t)}const g=f[p],y=n.splitter(g),b=y?y.length:30,v={WITH_TITLE:58,WITH_WEBLOGO:107,WITH_BOTH:156};let 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r.functions.call("Bio:Embed",{molecule:l});const c=vi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(t){console.warn(t)}try{i=i.replaceAll("\\n","\n");const t=new Blob([i],{type:"text/plain"}),e=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});e.style.setProperty("height","100%","important");const o=new NGL.Stage(e,{backgroundColor:"white"});o.loadFile(t,{ext:"sdf"}).then((function(t){o.setSize(300,300),t.addRepresentation("ball+stick"),t.autoView()})),n=s.div([e],{style:{aspectRatio:"1"}})}catch(t){n=s.divText("Couldn't get 3D structure")}}catch(t){n=s.divText("Couldn't get 3D structure")}return e.close(),new a.Widget(n)}(t)}function ko(){(0,Jn.D)({},eo.seqHelper).catch((t=>{const[e,n]=(0,Ct.AP)(t);if(t instanceof Xn.Ap)return r.shell.warning(t.element),void eo.logger.warning(e);r.shell.error(e),eo.logger.error(e,void 0,n)}))}async function Oo(t=null,e=null,n){return(0,Jn.D)({col:t,clustersCol:e,...n},eo.seqHelper)}async function Ho(){const t=r.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==a.SEMTYPE.MACROMOLECULE&&(eo.seqHelper.getSeqHandler(t),!0))),n=async e=>{if(!(0,Zn.V)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>eo.seqHelper.getSeqHandler(t).isMsa())),o=s.input.choice("Column",{value:i?i.name:t[0],items:t});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK((async()=>{const t=e.find((t=>t.name==o.value))??null;t&&await n(t)})).show()}else i=e[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}function Go(t){return new yt.m(t).importFasta()}function Fo(t){return console.log(t),[]}function Bo(){const t=(0,$t.me)()[0];(0,Me.C)(t,eo.seqHelper)}function Do(t){(0,Me.C)(t,eo.seqHelper)}function Vo(){return new ii}async function Wo(t){const e=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const o=[];for(const s of n)try{const e=await r.dapi.files.readAsText(t+s.fullPath),n=a.DataFrame.fromCsv(e);for(const t of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:t})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:t.name,message:`units: ${t.meta.units}`})}catch(t){o.push({file:s.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${t}`,s}async function Uo(t,e){return await async function(t,e){if(await(0,te.cb)(10),!(0,Zn.V)(e,"Sequence space"))return t;const n=eo.seqHelper,i=(0,vt.R)(e,n);i.name="splitToMonomers";const o=e.dataFrame;for(const t of i.columns)t.semType=Wt.uF.MONOMER,t.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=t=>{s.lastIndex=0;const e=t.match(s);return e?`${e[1]} (${parseInt(e[2]??"0")+1})`:t};for(let t=0;t<i.columns.length;t++){const n=i.columns.byIndex(t);n.semType=Wt.uF.MONOMER,n.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let t=0;t<i.columns.length;t++){const e=i.columns.byIndex(t);e.setTag(a.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return o}(t,e)}function jo(t){return eo.seqHelper.getSeqMonomers(t)}function qo(){return new Se(eo.seqHelper)}function zo(){const t=r.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Yo(){return new xe(eo.seqHelper)}function Ko(){const t=r.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Zo(t){const e=(0,$t.me)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new pe.a7(e,eo.seqHelper)}function Xo(t){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),r.shell.tv.grid.scrollToCell(t,0)}async function Jo(t,e,n){const i=eo.seqHelper;return gi(t,e,n,ft.IDENTITY,i)}async function Qo(t,e,n){const i=eo.seqHelper;return gi(t,e,n,ft.SIMILARITY,i)}async function tr(){Dn()}async function er(){await Vn()}async function nr(){const t=await Mn.getInstance();await t.getViewRoot()}async function ir(){return await Vn(!1)}async function or(t,e){(await(await dn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((e=>{const n=e.endsWith(".json")?e.substring(0,e.length-5):e;t.item(n).onSelected.subscribe((async()=>{const t=await Mn.getInstance();await t.getViewRoot(e,!0),t.resetCurrentRowFollowing()}))}))}function rr(){(0,Te.TE)()}function sr(){return new _e._i(eo.seqHelper,eo.logger)}function ar(){return new _e._i(eo.seqHelper,eo.logger)}async function lr(){const t=a.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoLargeApp"),n=await eo.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function cr(){const t=a.TaskBarProgressIndicator.create("WebLogo ...");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoAggApp"),n=await eo.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function hr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new pi(t,"getRegionApp");await e.init()}finally{t.close()}}async function ur(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await eo.files.readCsv("samples/HELM_empty_vals.csv"),n=new pi(t,"getRegionHelmApp");await n.init({df:e,colName:"HELM"})}finally{t.close()}}function dr(){const t=a.DataFrame.fromColumns((0,Lt.dW)());r.shell.addTableView(t)}function pr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(eo.seqHelper,gt.Hi.FASTA)]);r.shell.addTableView(t)}function mr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(eo.seqHelper,gt.Hi.HELM)]);r.shell.addTableView(t)}function fr(t,e){!function(t,e,n){const i=Object.values(gt.Hi).filter((t=>t!==gt.Hi.CUSTOM));e.group("Copy").items(i,(e=>{const i=t.column,o=t.rowIndex,s=n.getSeqHandler(i),a=e===gt.Hi.SEPARATOR?eo.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:e,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${e}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e,eo.seqHelper)}async function gr(){await async function(){const t=await eo.files.readCsv("samples/peptides-non-natural.csv");t.name="Similarity and Diversity Demo",t.col("activity").setTag("format","3 significant digits"),t.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const e=r.shell.addTableView(t);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const n=e.addViewer("Sequence Similarity Search",{limit:20}),i=e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,$t.Kd)(e.grid,"sequence",500,30);const o=e.addViewer("Sequence Diversity Search",{limit:20});e.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function yr(){await async function(){const t=await r.functions.eval("Bio:SeqSpaceDemo"),e=await r.dapi.projects.find(t.id);await e.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function br(){await async function(){const t=await eo.files.readCsv("tests/helm_cyclic_cliffs.csv");t.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(t),await t.meta.detectSemanticTypes();const e=r.shell.addTableView(t);s.setUpdateIndicator(e.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await To(t,t.getCol("Sequence"),t.getCol("Activity"),96,c.c.UMAP,ue.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),mn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),e.grid.props.rowHeight=180,e.grid.col("sequence")&&(e.grid.col("sequence").width=300),e.grid.col("structure")&&(e.grid.col("structure").width=300);const o=Array.from(e.viewers).find((t=>t!==e.grid&&t.type===a.VIEWER.GRID));o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,e.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(t){!function(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;r.shell.error(e),eo.logger.error(t.message,void 0,n)}(t)}finally{s.setUpdateIndicator(e.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function vr(){await async function(){const t=await eo.files.readCsv("samples/HELM_BI_CYCLIC.csv");t.name="To Atomic Level",await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const e=r.shell.addTableView(t),n=t.col("HELM");await No(t,n,!0,!1),(0,$t.Kd)(e.grid,"molfile(HELM)",500,300,!0),(0,$t.Kd)(e.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function wr(t){const e=(0,bt.uX)(t),n=JSON.stringify(e);a.Utils.download(`${t.name}.json`,n)}async function Cr(t,e){if(!t.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[t]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await no()).getMonomerLib(),l=eo.seqHelper,c=await(0,Pt.j)(),h=(await(0,fi.V)(i,n,e,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(t){const[e,n]=(0,Ct.AP)(t);throw eo.logger.error(e,void 0,n),t}}async function Ar(t,e){if(!t.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[t]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await gi(i,n,e,ft.IDENTITY,eo.seqHelper)).get(0)}catch(t){const[e,n]=(0,Ct.AP)(t);throw eo.logger.error(e,void 0,n),t}}async function Sr(t,e,n){const i=await t.readAsString();await async function(t,e,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(t),u=e?h.getCol(e):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,te.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,e,n)}async function xr(){return await ro(),eo.seqHelper}function Er(t,e,n){return async function(t,e,n=!0,i){const o=eo.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(e,n,eo.rdKitModule,i);return r.semType=a.SEMTYPE.MOLECULE,r}(0,e,n,eo.monomerLib)}function Mr(){return eo.logger.debug("Bio:test1() function"),{value:"value1"}}},6625:(t,e,n)=>{"use strict";n.d(e,{$:()=>r});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class o{seq1;seq2;score;constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class 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t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",r="";const s=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=r+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:r+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const o=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[o][e].parentJ}return new o(n,i,s)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>t&&(t=this.dpGrid[i][o].value,e=i,n=o);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.setMethod(i),this.setSequences(t,e),this.setGap(n)}}},4954:(t,e,n)=>{"use strict";n.d(e,{a7:()=>m,if:()=>g,BQ:()=>y,nI:()=>f});var i=n(4328),o=n(7389),r=n(6082),s=n(8070),a=n(2003),l=n(439);const c=31;async function h(t,e,n=!1,o){const s=e.getSeqHandler(t);let a;o??=new Map;const l=s.isHelm()?e.getSeqMonomers(t):Object.keys(s.stats.freq).filter((t=>""!==t));for(let t=0;t<l.length;t++)o.has(l[t])||o.set(l[t],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:t}),a=function(t,e,n=!1){const i=new Array(t.length);for(let o=0;o<t.length;o++){let r=0,s=0,a="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const l=t.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const h=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M  V30 COUNTS ${h} ${u} 0 0 0\n`,a+="M  V30 BEGIN ATOM\n";for(let t=0;t<h;t++){r=l.indexOf("\n",r)+1+c,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M  V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}a+="M  V30 END ATOM\n",a+="M  V30 BEGIN BOND\n";for(let t=0;t<u;t++){r=l.indexOf("\n",r)+1;const e=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M  V30 ${t+1} ${parseInt(l.substring(r+6,r+9).trim())} ${e} ${n}\n`}a+="M  V30 END BOND\n",a+="M  V30 END CTAB\n",a+="M  END",i[o]=a}return i}(a,o,n);else{a=new Array(t.length);for(let e=0;e<t.length;e++){const t=u(s.getSplitted(e),o,n);a[e]=t}}return r.Column.fromStrings("monomericMols",a)}function u(t,e,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let o=0;o<t.length;o++){const r=t.getCanonical(o);r!==l._S&&(i+=n?`M  V30 ${o+1} R${e.get(r)} 0.000 0.000 0 0\n`:`M  V30 ${o+1} At 0.000 0.000 0 0 MASS=${e.get(r)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M  V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}var d=n(4870);const p="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(t,e){this.seqHelper=e,this.col=t[0],this.createUI()}editHelmLinkAction(){(0,d.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(p,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,d.Ku)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:t,value:this.col,onValueChanged:t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()},filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const e=r.DataFrame.create(1);e.columns.addNewString(p).init((t=>"")),e.col(p).semType=this.col.semType,e.col(p).meta.units=a.Hi.HELM,this.grid=e.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,n=this.units===a.Hi.HELM?e.get(p,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),t=this.units===a.Hi.HELM?await g(n,this.col,this.seqHelper):f(n,this.col),this.col.dataFrame.filter.and(t)})).show()}}function f(t,e,n){const i=n?function(t,e){const n=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,o=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(t,n):t,o=r.BitSet.create(e.length);for(let n=0;n<e.length;n++){const r=e.get(n);(r.match(i)||r===t)&&o.set(n,!0,!1)}return o}async function g(t,e,n){e.version!==e.temp["last-invalidated-version"]&&await y(e,n,!0);const o=r.Column.string("helm",1).init((e=>t));o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await h(o,n,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function y(t,e,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);try{await(0,s.cb)(10);const i=new Map,o=await h(t,e,n,i);t.temp["monomeric-mols"]=o,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version}finally{i.close()}}},966:(t,e,n)=>{"use strict";n.d(e,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(6723);function s(t,e,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,h]=a(t,e,l,n,o);return s&&!c&&i.shell.warning(h),c}function a(t,e,n,r=[],s=[]){let a=!0,l="";if(t.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(t),o=i.notation;if(r.length>0&&!r.some((t=>o.toUpperCase()==t.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const t=i.alphabet;s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(t,e,n)=>{"use strict";n.d(e,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>r});var i,o,r,s,a,l=n(8152);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(o||(o={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(s||(s={})),function(t){t.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(t,e,n)=>{"use strict";n.d(e,{C:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(t,e){let n=t??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=e.getSeqHandler(n),u=s.notation;const d=o.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=o.input.column("Column",{table:r.shell.t,value:n,filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:t=>(n=t,s=e.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((t=>t!==u)),v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(o.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((t=>t!==u));const y=o.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=o.dialog("Convert Sequence Notation").add(o.div([d,m.root,v.root,y.root])).onOK((async()=>{const t=v.value,i=t===l.Hi.SEPARATOR?y.value:void 0;await async function(t,e,n,i){const o=e.getSeqHandler(t).convert(n,i);t.dataFrame.columns.add(o);const s=await r.functions.call("Bio:detectMacromolecule",{col:o});return s&&(o.semType=s),await r.data.detectSemanticTypes(t.dataFrame),o}(n,e,t,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((t=>{h.forEach((t=>{t.unsubscribe()})),h=[],c=null}))))}},536:(t,e,n)=>{"use strict";n.d(e,{Z:()=>o});var i=n(6956);class o{constructor(t){const e=t.split(i.xe).filter((t=>t));e.forEach((t=>this.validateConnectionItem(t))),this.connectionItems=e}connectionItems;validateConnectionItem(t){const e="(PEPTIDE|RNA)",n=new RegExp(`${e}[0-9]+,${e}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!t.match(n))throw new Error(`Cannot parse connection item from ${t}`)}getConnectionData(){const t=[];return this.connectionItems.forEach((e=>{const n=[],i=e.split(",");i[2].split("-").forEach(((t,e)=>{const o=i[e],r=t.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})})),t.push(n)})),t}}},6956:(t,e,n)=>{"use strict";n.d(e,{mP:()=>r,pk:()=>o,xe:()=>i});const i="|",o="$",r="H"},9099:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(536),o=n(6956),r=n(9034);class s{helmString;constructor(t){this.helmString=t;const e=this.helmString.split(o.pk),n=e[0].split(o.xe);this.simplePolymers=n.map((t=>new r.d(t))),this.connectionList=new i.Z(e[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const t=this.simplePolymers.map((t=>t.monomers.length)).reduce(((t,e)=>t+e),0),e=Array.from({length:t},(()=>[]));return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e[n].push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(t){return this.getSimplePolymerByMonomerIdx(t).polymerType}getSimplePolymerByMonomerIdx(t){const e=this.getMonomerIdxShifts(),n=Object.values(e).sort(((t,e)=>t-e)).find((e=>t>=e));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${t}`);const i=Object.keys(e).find((t=>e[t]===n));return this.simplePolymers.find((t=>t.id===i))}shiftBondMonomerIds(t,e){e.forEach((e=>{e.forEach((e=>{e.monomerIdx+=t}))}))}getMonomerIdxShifts(){const t={};let e=0;return this.simplePolymers.forEach((n=>{t[n.id]=e,e+=n.monomers.length})),t}getBondData(){const t=this.getMonomerIdxShifts(),e=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),o=t[n.id];this.shiftBondMonomerIds(o,i),e.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((e=>{const n=t[e.polymerId],o=e.bond;o.monomerIdx+=n,i.push(o)})),e.push(i)})),e}}},9034:(t,e,n)=>{"use strict";n.d(e,{d:()=>o});var i=n(8438);class o{simplePolymer;isNucleotideSequence=!1;constructor(t){this.simplePolymer=t,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:e,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=e,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const t=new RegExp("(PEPTIDE|RNA)[0-9]+{"),e=this.simplePolymer.match(t);if(!e)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return e[1]}getIdx(){const t=new RegExp(`${this.polymerType}([0-9]+){`),e=this.simplePolymer.match(t);if(!e)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(e[1])}getMonomerSymbolsAndTypes(){const t=new 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i=["NH2","COOH"];if(t.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==t[n],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=n}if(t.endsWith(i[1])){const e=i[1].length+1;(0,N.vA)("-"==t[n-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),n-=e}return t.substring(e,n)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return $._dropDefises($._truncateSequence(t))}encode(t){const e=t.length,n=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,N.vA)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),n[i]=this.encodeLettter(e)}return n}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let n=0;n<t.length;++n){const i=t[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var R=n(4139);const k="input.fa",O="result.fasta";class H extends Error{element;constructor(t,e){super(t.innerText,e),this.element=t}}function G(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}async function F(t,e,n=!1,i="",r=null,s,c,h,u){let d=e.toList();n&&(d=d.map((t=>$.clean(t).replace(/\-/g,""))));const p=e.length;r??=o.Column.string("Clusters",p).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const m=r.categories,f=r.getRawData(),g=new Array(m.length),y=new Array(m.length);if(u){const e=t.selection;if(0===e.length)throw new Error("No selected rows in the table.");for(let t=-1;-1!==(t=e.findNext(t,!0));){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}}else for(let t=0;t<p;++t){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}D(y,m);const b=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),v=o.Column.string(i,p);for(let t=0;t<m.length;++t){const e=g[t];if(!e||0===e.length)continue;const n=G(e);await b.fs.writeFile(k,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==h?` --tgpe ${h}`:""}`,o=await b.exec(`kalign ${k} -f 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i=n(4328),o=n(6082),r=n(2003),s=n(608),a=n(4139),l=n(6723);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],u=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(t,e,n,i="ginsi",l=1.53,h=0,d=null,m,f=!1){const g=await c.getDockerContainer(),y=e.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(f){const n=t.selection;for(let t=-1;-1!==(t=n.findNext(t,!0));){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}}else for(let t=0;t<y;++t){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}(0,s.aZ)(C,b);const A=new 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w,C,A=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new r.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class S{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(t=0,e){this.value=this.rowCount=t,this.bounds=e}push(t){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=t,++this.valueIdx}aggregate(t){this.value=t(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(t,e,n,i){this.pos=t,this.name=e,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new S),e}aggregate(t){const e=function(t){return e=>{const n=function(t){let e;const n="agg";return e=t instanceof Float32Array?r.Column.fromFloat32Array(n,t):t instanceof Int32Array?r.Column.fromInt32Array(n,t):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,t),e}(e);return n.aggregate(t)}}(t);for(const[t,n]of Object.entries(this._freqs))n.aggregate(e)}getMinValue(){return Math.min(...Object.values(this._freqs).map((t=>t.value)))}calcPlotValue(t){for(const e of Object.values(this._freqs))e.plotValue=e.value-t}calcHeights(t){this.sumPlotValue=0;for(const t of Object.values(this._freqs))this.sumPlotValue+=t.plotValue;if(this.sumPlotValueForHeight=0,t===d.fH.Entropy){const t=Object.keys(this._freqs).length,e=.01*this.sumPlotValue,n=e/t;for(const t of Object.values(this._freqs)){const i=(t.plotValue+n)/(this.sumPlotValue+e);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(t===d.fH.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=t}}calcScreen(t,e,n,i,o,s,a,l,c){const h=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort(((t,e)=>t[0]!==g._S&&e[0]!==g._S?e[1].value-t[1].value:t[0]===g._S&&e[0]===g._S?0:t[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((t-e)*l*s,u,a*l,n),u+=n}}render(t,e,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;r&&(p=r.getMonomerTextColor(o,a)),t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(d,h.top,h.width,h.height),t.fillStyle=p,t.textAlign="left",t.font=e;const m=t.measureText(c);t.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),t.fillText(c,0,-n)}}getMonomerAt(t,e){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(t,e)));return n?n[0]:void 0}buildCompositionTable(t,e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol 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E=d.Fo;var M;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(M||(M={}));const T=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,E.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const t=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],e=Object.values(r.AGG).filter((e=>!t.includes(e)));this.valueColumnName=this.string(C.valueColumnName,E.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,E.valueAggrType,{category:w.DATA,choices:e,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,E.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,E.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,E.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,E.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,E.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,E.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,E.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,E.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,E.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,E.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,E.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,E.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,E.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,E.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,E.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,E.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,E.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,E.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,b.getMonomerLibHelper)().then((t=>{this.monomerLib=t.getMonomerLib(),this.render(M.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(M.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const t=`${this.toLog()}.setData()`;b._package.logger.debug(`${t}, in`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),b._package.logger.debug(`${t}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(M.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(t){const e={width:t.target.clientWidth,height:t.target.clientHeight};this.lastSize.width==e.width&&this.lastSize.height==e.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(e)}, start `),this.render(M.Layout,"rootOnSizeChanged")),this.lastSize=e}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((t=>t.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(M.Freqs,"updateSeqCol()"),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let t;switch(this.filterSource){case d.lT.Filtered:t=this.dataFrame.filter;break;case d.lT.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=n*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;let e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e);this.fitArea&&e<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/e),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=e>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*t,this.canvas.height=i*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}safeUpdateSlider(t,e,n,i){v(t,this.slider.minRange,.1)&&v(e,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(t,e,n,i)}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(M.Freqs,`onPropertyChanged( ${t.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(M.Layout,`onPropertyChanged(${t.name})`);break;case C.backgroundColor:this.render(M.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const t=`${this.toLog()}.detach()`;b._package.logger.debug(`${t}, in`);const e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),e())})),b._package.logger.debug(`${t}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const n=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,t.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((t=>!t.hasMonomer(g._S)||t.getFreq(g._S).rowCount!==t.sumRowCount)).toArray())}requestedRenderLevel=M.Freqs;renderRequest=new h.Subject;renderRequestSub;render(t,e){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(t>=M.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.seqCol.getTag(u.gp.positionNames),e=this.seqCol.getTag(u.gp.positionLabels);let n;!t&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):t&&this.endPositionName&&(n=t.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((t=>{const e=this.seqHandler.getSplitted(t,n);return i.get(t)&&e?e.length:0})).reduce(((t,e)=>Math.max(t,e)),0);this.positionNames=t?t.split(u.z1).map((t=>t.trim())):[...Array(o).keys()].map((t=>`${t+1}`)),this.positionLabels=e?e.split(u.z1).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let t=0;t<s;t++){const e=this.positionNames[this.startPosition+t],n=this.positionLabels?this.positionLabels[this.startPosition+t]:void 0;this.positions[t]=new x(this.startPosition+t,e,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let t=0;t<s;++t){for(const e of l){const n=this.seqHandler.getSplitted(e),i=t+this.startPosition<n.length?n.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?g._S:i,r=this.positions[t],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let e=null;try{e=this.dataFrame.getCol(this.valueColumnName),e.matches("numerical")||(e=null)}catch{e=null}if(e){for(const n of l){const i=this.seqHandler.getSplitted(n),o=t+this.startPosition<i.length?i.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?g._S:o,s=e.get(n);this.positions[t].getFreq(r).push(s)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((t=>t.getMinValue()))));for(let t=0;t<s;++t)this.positions[t].calcPlotValue(h),this.positions[t].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));t>=M.Layout&&((t,e,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==t&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(t)}else a=Math.max(...c().count(t).takeWhile((t=>t<=e)).map((t=>this.positions[t].sumPlotValueForHeight)));for(let i=t;i<=e;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const t=10*e;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${t.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(t,e,n,i,o,r,s,a){t.save();try{t.textAlign="center";let l=null,c=null;for(let e=Math.floor(s);e<=Math.floor(a);e++){const n=r[e],i=t.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const h=l<i*e-2?1:(i*e-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],u=(l-s)*n*e+i*e/2,d=(o*e-c)/2;t.setTransform(h,0,0,1,u,d),t.measureText(a.label),t.fillText(a.label,0,0)}}finally{t.restore()}}(a,e,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let t=o;t<=s;t++)this.positions[t].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${t} ), end`)}}renderRequestOnDebounce(t){const e=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=M.None,this.viewSyncer.sync(e,(async()=>{await this.renderInt(t)}))):b._package.logger.warning(`${e}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const e=t.max-t.min,n=this.canvas.offsetWidth/e-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(M.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(M.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(M.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){if(!this.monomerLib||!this.seqHandler)return;const e=window.devicePixelRatio;try{const n=t,i=this.canvas.getCursorPosition(n,e),[s,a]=this.getMonomer(i,e),l=this.showPositionLabels?12*e:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const t=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.defaultBiotype;t.push(s.buildCompositionTable(e,this.monomerLib))}const e=o.divV(t);e.style.maxHeight="80vh",o.tooltip.show(e,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=s.getFreq(a),e=[o.div(`${a}`),o.div(`${t.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&e.push(o.div(`${this.valueAggrType}: ${t.value.toFixed(3)}`));const i=o.divV(e);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(e,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=r.BitSet.create(this.dataFrame.selection.length,(t=>function(t,e,n,i,o,r){const s=e.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),t,o,i)));this.dataFrame.selection.init((e=>t.get(e)))}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+e)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`invalidate(${t?` <- ${t} `:""})`,n=`${this.toLog()}.${e}`;this.render(M.None,e),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}},1687:(t,e,n)=>{"use strict";n.d(e,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(4954),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(6723);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(t){super(),this.seqHelper=t,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const t of this.viewSubs)t.unsubscribe()}async attach(){this.viewerToLog();try{const t=await(0,g.b2)();let e,n;this.helmEditor=t.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{e=i.div(),n=t.createWebEditorApp(e,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{try{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(t,void 0,v._package.logger)}catch(t){this.logger.error(t)}finally{f()(e).empty(),e=null,n=null}})).onCancel((()=>{f()(e).empty(),e=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((t=>{try{if(n){const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(t)}}catch(t){const[e,n]=(0,y.AP)(t);this.logger.error(e,void 0,n)}})))}catch(t){const[e,n]=(0,y.AP)(t),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,e)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(t){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=e/2;if(t)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,n);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,t)}}async substructureSearch(t){const e=`${this.viewerToLog()}.substructureSearch( column = <${t.name}> )`;v._package.logger.debug(`${e}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,t,this.seqHelper)}finally{v._package.logger.debug(`${e}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(t,e,n,i,o){this.props=t,this.filterId=e,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends p.n{separator;constructor(t,e,n){super(t,!1,n),this.separator=e,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(t,e){super(),this.seqHelper=t,this.logger=e,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(t){const e=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{e(t),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=t.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const t=super.detach.bind(this),e=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(e,(async()=>{for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[],t(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(t){t.filterId!==this.filterId&&t.dataFrameId===this.dataFrame.id&&t.columnName===this.columnName&&(this.bioFilter.props=t.props)}applyFilter(){const t=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${t}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=`${this.filterToLog()}.saveState()`,e=super.saveState();return this.logger.debug(`${t}, super.state = ${JSON.stringify(e)}`),e.props=this.bioFilter.saveProps(),e}applyState(t){const e=`${this.filterToLog()}.applyState()`;super.applyState(t),this.filterSyncer.sync(e,(async()=>{t.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(t.props??{}))}))}fireFilterSync(){const t=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${t}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const t=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${t}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(t,(async()=>{this.calculating=!0;try{this.logger.debug(`${t}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${t}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${t}, end`)}}))}grokEventsOnResetFilterRequest(){const t=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${t}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.filterToLog()}.invalidate(${t?` <- ${t} `:""})`;this.filterSyncer.sync(e,(async()=>{this._onRendered.next()}))}async awaitRendered(t=1e4){const e=`awaitRendered( ${t} )`,n=`${this.filterToLog()}.${e}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(e)}),t,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{window.setTimeout((()=>{this.props=new p.n(t,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(t){return(0,d.nI)(this.props.substructure,t)}async attach(){}async detach(){await super.detach()}}class M extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(t){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{this.props=new S(t,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=t,onValueChanged:t=>{const e=t||"";this.props=new S(this.props.substructure,e,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const t=this.props.separator??this.colSeparator;this.separatorInput.value!==t&&(this.separatorInput.value=t)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,d.nI)(this.substructure,t,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:t=>{"use strict";t.exports=$},6082:t=>{"use strict";t.exports=DG},4328:t=>{"use strict";t.exports=grok},1858:t=>{"use strict";t.exports=rxjs},9713:t=>{"use strict";t.exports=rxjs.operators},7389:t=>{"use strict";t.exports=ui},1991:t=>{"use strict";t.exports=wu},8343:(t,e,n)=>{"use 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n={host:t.host,scheme:t.scheme,userinfo:t.userinfo,port:t.port,path:t.path,query:t.query,nid:t.nid,nss:t.nss,uuid:t.uuid,fragment:t.fragment,reference:t.reference,resourceName:t.resourceName,secure:t.secure,error:""},i=Object.assign({},e),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let t=n.path;i.absolutePath||a&&a.absolutePath||(t=r(t)),void 0===c&&(t=t.replace(/^\/\//u,"/%2F")),o.push(t)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const u=Array.from({length:127},((t,e)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(e)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(t,e){const n=Object.assign({},e),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==t.indexOf("%");let a=!1;"suffix"===n.reference&&(t=(n.scheme?n.scheme+":":"")+"//"+t);const c=t.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const t=o(r.host);if(!1===t.isIPV4){const e=i(t.host);r.host=e.host.toLowerCase(),a=e.isIPV6}else r.host=t.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 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0!==o.undirected&&(a=l(t,o.undirected,r,s),t&&a))return a}var ht=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ut(){this.A=null,this.B=null}function dt(t,e,n,i,o){for(var r in i){var s=i[r],a=s.source,l=s.target,c=a===n?l:a;if(!e||!e.has(c.key)){var h=o(c.key,c.attributes);if(t&&h)return c.key}}}function pt(t,e,n,i,o){if("mixed"!==e){if("undirected"===e)return dt(t,null,i,i.undirected,o);if("string"==typeof n)return dt(t,null,i,i[n],o)}var r,s=new ut;if("undirected"!==e){if("out"!==n){if(r=dt(t,null,i,i.in,o),t&&r)return r;s.wrap(i.in)}if("in"!==n){if(r=dt(t,s,i,i.out,o),t&&r)return r;s.wrap(i.out)}}if("directed"!==e&&(r=dt(t,s,i,i.undirected,o),t&&r))return r}function mt(t,e,n){var i=Object.keys(n),o=i.length,r=0;return new N((function(){var s=null;do{if(r>=o)return t&&t.wrap(n),{done:!0};var a=n[i[r++]],l=a.source,c=a.target;s=l===e?c:l,t&&t.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ft(t,e,n,i,o){for(var r,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(r=d.next()).done;){var m=!1;if(s=r.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(e&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=o(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=o(s.key,null,s.attributes,null,null,null,null),t&&u))return null}}function gt(t){if(!c(t))throw new B('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in t))throw new B("Graph.import: serialized node is missing its key.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function yt(t){if(!c(t))throw new B('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in t))throw new B("Graph.import: serialized edge is missing its source.");if(!("target"in t))throw new B("Graph.import: serialized edge is missing its target.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new B("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in t&&"boolean"!=typeof t.undirected)throw new B("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ut.prototype.wrap=function(t){null===this.A?this.A=t:null===this.B&&(this.B=t)},ut.prototype.has=function(t){return null!==this.A&&t in this.A||null!==this.B&&t in this.B};var bt,vt=(bt=255&Math.floor(256*Math.random()),function(){return bt++}),wt=new Set(["directed","undirected","mixed"]),Ct=new Set(["domain","_events","_eventsCount","_maxListeners"]),At={allowSelfLoops:!0,multi:!1,type:"mixed"};function St(t,e,n){var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}function xt(t,e,n,i,o,r,s,a){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new B("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(r=""+r,s=""+s,a=a||{},!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=t._nodes.get(r),h=t._nodes.get(s);if(!l)throw new V("Graph.".concat(e,': source node "').concat(r,'" not found.'));if(!h)throw new V("Graph.".concat(e,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:r,target:s,attributes:a};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));if(!t.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new W("Graph.".concat(e,': an edge linking "').concat(r,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,o,l,h,a);t._edges.set(o,d);var p=r===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,t._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,u.key=o,t.emit("edgeAdded",u),o}function Et(t,e,n,i,o,r,s,l,h){if(!i&&"undirected"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new W("Graph.".concat(e,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new B("Graph.".concat(e,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new B("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(r=""+r,s=""+s,h&&(u=l,l=void 0),!t.allowSelfLoops&&r===s)throw new W("Graph.".concat(e,': source & target are the same ("').concat(r,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=t._nodes.get(r),f=t._nodes.get(s);if(!n&&(d=t._edges.get(o))){if(!(d.source.key===r&&d.target.key===s||i&&d.source.key===s&&d.target.key===r))throw new W("Graph.".concat(e,': inconsistency detected when attempting to merge the "').concat(o,'" edge with "').concat(r,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||t.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),t.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),t.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:r,target:s,attributes:l};if(n)o=t._edgeKeyGenerator();else if(o=""+o,t._edges.has(o))throw new W("Graph.".concat(e,': the "').concat(o,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=St(t,r,{}),v=!0,r===s&&(f=m,w=!0)),f||(f=St(t,s,{}),w=!0),d=new z(i,o,m,f,l),t._edges.set(o,d);var C=r===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,t._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,b.key=o,t.emit("edgeAdded",b),[o,!0,v,w]}function Tt(t,e){t._edges.delete(e.key);var n=e.source,i=e.target,o=e.attributes,r=e.undirected,s=n===i;r?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,t._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,t._directedSelfLoopCount--)),t.multi?e.detachMulti():e.detach(),r?t._undirectedSize--:t._directedSize--,t.emit("edgeDropped",{key:e.key,attributes:o,source:n.key,target:i.key,undirected:r})}var Mt=function(n){function i(t){var e;if(e=n.call(this)||this,"boolean"!=typeof(t=a({},At,t)).multi)throw new B("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(t.multi,'".'));if(!wt.has(t.type))throw new B('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(t.type,'".'));if("boolean"!=typeof t.allowSelfLoops)throw new B("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(t.allowSelfLoops,'".'));var i="mixed"===t.type?U:"directed"===t.type?j:q;u(s(e),"NodeDataClass",i);var o="geid_"+vt()+"_",r=0;return u(s(e),"_attributes",{}),u(s(e),"_nodes",new Map),u(s(e),"_edges",new Map),u(s(e),"_directedSize",0),u(s(e),"_undirectedSize",0),u(s(e),"_directedSelfLoopCount",0),u(s(e),"_undirectedSelfLoopCount",0),u(s(e),"_edgeKeyGenerator",(function(){var t;do{t=o+r++}while(e._edges.has(t));return t})),u(s(e),"_options",t),Ct.forEach((function(t){return u(s(e),t,e[t])})),d(s(e),"order",(function(){return e._nodes.size})),d(s(e),"size",(function(){return e._edges.size})),d(s(e),"directedSize",(function(){return e._directedSize})),d(s(e),"undirectedSize",(function(){return e._undirectedSize})),d(s(e),"selfLoopCount",(function(){return e._directedSelfLoopCount+e._undirectedSelfLoopCount})),d(s(e),"directedSelfLoopCount",(function(){return e._directedSelfLoopCount})),d(s(e),"undirectedSelfLoopCount",(function(){return e._undirectedSelfLoopCount})),d(s(e),"multi",e._options.multi),d(s(e),"type",e._options.type),d(s(e),"allowSelfLoops",e._options.allowSelfLoops),d(s(e),"implementation",(function(){return"graphology"})),e}e(i,n);var o=i.prototype;return o._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},o.hasNode=function(t){return this._nodes.has(""+t)},o.hasDirectedEdge=function(t,e){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.out.hasOwnProperty(e)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasUndirectedEdge=function(t,e){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){t=""+t,e=""+e;var o=this._nodes.get(t);return!!o&&o.undirected.hasOwnProperty(e)}throw new B("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.hasEdge=function(t,e){if(1===arguments.length){var n=""+t;return this._edges.has(n)}if(2===arguments.length){t=""+t,e=""+e;var i=this._nodes.get(t);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(e)||void 0!==i.undirected&&i.undirected.hasOwnProperty(e))}throw new B("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},o.directedEdge=function(t,e){if("undirected"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.directedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||void 0;return i?i.key:void 0}},o.undirectedEdge=function(t,e){if("directed"!==this.type){if(t=""+t,e=""+e,this.multi)throw new W("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.undirected&&n.undirected[e]||void 0;return i?i.key:void 0}},o.edge=function(t,e){if(this.multi)throw new W("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.edge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.edge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||n.undirected&&n.undirected[e]||void 0;if(i)return i.key},o.areDirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)},o.areOutNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out},o.areInNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in},o.areUndirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"directed"!==this.type&&e in n.undirected},o.areNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)||"directed"!==this.type&&e in n.undirected},o.areInboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in||"directed"!==this.type&&e in n.undirected},o.areOutboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out||"directed"!==this.type&&e in n.undirected},o.inDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree},o.outDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree},o.directedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree},o.undirectedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegree: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree},o.inboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree),n},o.outboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.outDegree),n},o.degree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree),n},o.inDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree-e.directedLoops},o.outDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree-e.directedLoops},o.directedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree-2*e.directedLoops},o.undirectedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree-2*e.undirectedLoops},o.inboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree,i+=e.directedLoops),n-i},o.outboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.outDegree,i+=e.directedLoops),n-i},o.degreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree,i+=2*e.directedLoops),n-i},o.source=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.source: could not find the "'.concat(t,'" edge in the graph.'));return e.source.key},o.target=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.target: could not find the "'.concat(t,'" edge in the graph.'));return e.target.key},o.extremities=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.extremities: could not find the "'.concat(t,'" edge in the graph.'));return[e.source.key,e.target.key]},o.opposite=function(t,e){t=""+t,e=""+e;var n=this._edges.get(e);if(!n)throw new V('Graph.opposite: could not find the "'.concat(e,'" edge in the graph.'));var i=n.source.key,o=n.target.key;if(t===i)return o;if(t===o)return i;throw new V('Graph.opposite: the "'.concat(t,'" node is not attached to the "').concat(e,'" edge (').concat(i,", ").concat(o,")."))},o.hasExtremity=function(t,e){t=""+t,e=""+e;var n=this._edges.get(t);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(t,'" edge in the graph.'));return n.source.key===e||n.target.key===e},o.isUndirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isUndirected: could not find the "'.concat(t,'" edge in the graph.'));return e.undirected},o.isDirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isDirected: could not find the "'.concat(t,'" edge in the graph.'));return!e.undirected},o.isSelfLoop=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isSelfLoop: could not find the "'.concat(t,'" edge in the graph.'));return e.source===e.target},o.addNode=function(t,e){var n=function(t,e,n){if(n&&!c(n))throw new B('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(e=""+e,n=n||{},t._nodes.has(e))throw new W('Graph.addNode: the "'.concat(e,'" node already exist in the graph.'));var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}(this,t,e);return n.key},o.mergeNode=function(t,e){if(e&&!c(e))throw new B('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(e,'"'));t=""+t,e=e||{};var n=this._nodes.get(t);return n?(e&&(a(n.attributes,e),this.emit("nodeAttributesUpdated",{type:"merge",key:t,attributes:n.attributes,data:e})),[t,!1]):(n=new this.NodeDataClass(t,e),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:e}),[t,!0])},o.updateNode=function(t,e){if(e&&"function"!=typeof e)throw new B('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(e,'"'));t=""+t;var n=this._nodes.get(t);if(n){if(e){var i=n.attributes;n.attributes=e(i),this.emit("nodeAttributesUpdated",{type:"replace",key:t,attributes:n.attributes})}return[t,!1]}var o=e?e({}):{};return n=new this.NodeDataClass(t,o),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:o}),[t,!0]},o.dropNode=function(t){t=""+t;var e,n=this._nodes.get(t);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(t,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){e=n.out[i];do{Tt(this,e),e=e.next}while(e)}for(var o in n.in){e=n.in[o];do{Tt(this,e),e=e.next}while(e)}}if("directed"!==this.type)for(var r in n.undirected){e=n.undirected[r];do{Tt(this,e),e=e.next}while(e)}this._nodes.delete(t),this.emit("nodeDropped",{key:t,attributes:n.attributes})},o.dropEdge=function(t){var e;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(e=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(t=""+t,!(e=this._edges.get(t)))throw new V('Graph.dropEdge: could not find the "'.concat(t,'" edge in the graph.'));return Tt(this,e),this},o.dropDirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t=""+t,e=""+e,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Tt(this,n),this},o.dropUndirectedEdge=function(t,e){if(arguments.length<2)throw new W("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new W("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t,e,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Tt(this,n),this},o.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},o.clearEdges=function(){for(var t,e=this._nodes.values();!0!==(t=e.next()).done;)t.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},o.getAttribute=function(t){return this._attributes[t]},o.getAttributes=function(){return this._attributes},o.hasAttribute=function(t){return this._attributes.hasOwnProperty(t)},o.setAttribute=function(t,e){return this._attributes[t]=e,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.updateAttribute=function(t,e){if("function"!=typeof e)throw new B("Graph.updateAttribute: updater should be a function.");var n=this._attributes[t];return this._attributes[t]=e(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},o.removeAttribute=function(t){return delete this._attributes[t],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:t}),this},o.replaceAttributes=function(t){if(!c(t))throw new B("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=t,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},o.mergeAttributes=function(t){if(!c(t))throw new B("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,t),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:t}),this},o.updateAttributes=function(t){if("function"!=typeof t)throw new B("Graph.updateAttributes: provided updater is not a function.");return this._attributes=t(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},o.updateEachNodeAttributes=function(t,e){if("function"!=typeof t)throw new B("Graph.updateEachNodeAttributes: expecting an updater function.");if(e&&!p(e))throw new B("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o=this._nodes.values();!0!==(n=o.next()).done;)(i=n.value).attributes=t(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:e||null})},o.updateEachEdgeAttributes=function(t,e){if("function"!=typeof t)throw new B("Graph.updateEachEdgeAttributes: expecting an updater function.");if(e&&!p(e))throw new B("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,o,r,s=this._edges.values();!0!==(n=s.next()).done;)o=(i=n.value).source,r=i.target,i.attributes=t(i.key,i.attributes,o.key,r.key,o.attributes,r.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:e||null})},o.forEachAdjacencyEntry=function(t){if("function"!=typeof t)throw new B("Graph.forEachAdjacencyEntry: expecting a callback.");ft(!1,!1,!1,this,t)},o.forEachAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new B("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!1,!0,this,t)},o.forEachAssymetricAdjacencyEntry=function(t){if("function"!=typeof t)throw new B("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ft(!1,!0,!1,this,t)},o.forEachAssymetricAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new B("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!0,!0,this,t)},o.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):F(this._nodes.keys(),this._nodes.size)},o.forEachNode=function(t){if("function"!=typeof t)throw new B("Graph.forEachNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)},o.findNode=function(t){if("function"!=typeof t)throw new B("Graph.findNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return n.key},o.mapNodes=function(t){if("function"!=typeof t)throw new B("Graph.mapNode: expecting a callback.");for(var e,n,i=this._nodes.values(),o=new Array(this.order),r=0;!0!==(e=i.next()).done;)n=e.value,o[r++]=t(n.key,n.attributes);return o},o.someNode=function(t){if("function"!=typeof t)throw new B("Graph.someNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return!0;return!1},o.everyNode=function(t){if("function"!=typeof t)throw new B("Graph.everyNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(!t((n=e.value).key,n.attributes))return!1;return!0},o.filterNodes=function(t){if("function"!=typeof t)throw new B("Graph.filterNodes: expecting a callback.");for(var e,n,i=this._nodes.values(),o=[];!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)&&o.push(n.key);return o},o.reduceNodes=function(t,e){if("function"!=typeof t)throw new B("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new B("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,o=e,r=this._nodes.values();!0!==(n=r.next()).done;)o=t(o,(i=n.value).key,i.attributes);return o},o.nodeEntries=function(){var t=this._nodes.values();return new N((function(){var e=t.next();if(e.done)return e;var n=e.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},o.export=function(){var t=this,e=new Array(this._nodes.size),n=0;this._nodes.forEach((function(t,i){e[n++]=function(t,e){var n={key:t};return h(e.attributes)||(n.attributes=a({},e.attributes)),n}(i,t)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(e,o){i[n++]=function(t,e,n){var i={key:e,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===t&&n.undirected&&(i.undirected=!0),i}(t.type,o,e)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:e,edges:i}},o.import=function(t){var e,n,o,r,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(t instanceof i)return t.forEachNode((function(t,e){l?a.mergeNode(t,e):a.addNode(t,e)})),t.forEachEdge((function(t,e,n,i,o,r,s){l?s?a.mergeUndirectedEdgeWithKey(t,n,i,e):a.mergeDirectedEdgeWithKey(t,n,i,e):s?a.addUndirectedEdgeWithKey(t,n,i,e):a.addDirectedEdgeWithKey(t,n,i,e)})),this;if(!c(t))throw new B("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(t.attributes){if(!c(t.attributes))throw new B("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(t.attributes):this.replaceAttributes(t.attributes)}if(t.nodes){if(o=t.nodes,!Array.isArray(o))throw new B("Graph.import: invalid nodes. Expecting an array.");for(e=0,n=o.length;e<n;e++){gt(r=o[e]);var h=r,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(t.edges){var p=!1;if("undirected"===this.type&&(p=!0),o=t.edges,!Array.isArray(o))throw new B("Graph.import: invalid edges. 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async 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n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:t,fnNames:e,startRow:y,startCol:b,chunckSize:g-i,opts:o,weights:r,aggregationMethod:s}),l[n]=new Promise(((t,e)=>{this._workers[n].onmessage=({data:{error:o,distanceMatrixData:r,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),o?e(o):(u.set(r,i),s<m&&(m=s),a>f&&(f=a),t())}}))}await Promise.all(l),n&&u.forEach(((t,e)=>{u[e]=(t-m)/(f-m)})),i(u)}catch(t){a(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(t,e=1e6){const n=200,i=new Uint32Array(n),o=t.distance.length,r=t.distance;for(let t=0;t<o;t++)i[Math.floor(r[t]*n)]++;let s=0,a=0;for(let t=0;t<n&&(s+=i[t],a=t,!(s>=e));t++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=t.i,d=t.j;let p=0;const m=(a+1)/n;for(let t=0;t<o;t++)r[t]<m&&(l[p]=u[t],c[p]=d[t],h[p]=r[t],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(t,e,o,r=[{}],s=[1],a=i.EUCLIDEAN){const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=t[0].length>2e4?await this.getMinimalThreshold(t,e,r,s,a):0;o<h&&(console.log(`using threshold ${h}`),o=h),r.forEach(((t,e)=>r[e].threshold=o));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:t,startIdx:u,endIdx:p,threshold:o,fnNames:e,opts:r,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:t,i:e,j:o,distance:r}})=>{t?(d[n].terminate(),h(t)):(d[n].terminate(),i({i:e,j:o,distance:r,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((t,e)=>t+e.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const t of p)f.set(t.i,b),g.set(t.j,b),y.set(t.distance,b),b+=t.i.length;return{i:f,j:g,distance:y}}async calc(t,e,n,i={}){return await this.calcMultiColumn([t],[e],n,[i],[1])}async getKNN(t,e,n=15,i={}){return await this.multiColumnKNN([t],[e],n,[i],[1])}async getThresholdKNN(t,e,n=.8,i={}){return await this.multiColumnThresholdKnn([t],[e],n,[i],[1])}async multiColumnThresholdKnn(t,e,o=.8,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,threshold:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p=new Int32Array(t[0].length);for(const e of d)for(let n=0;n<t[0].length;++n)p[n]+=e.knnIndexes[n]?.length??0;const m={knnDistances:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e]))),knnIndexes:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e])))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)m.knnDistances[n][p[n]-1]=e.knnDistances[n][t],m.knnIndexes[n][p[n]-1]=e.knnIndexes[n][t],p[n]-=1;return m}async multiColumnSingleValueKNN(t,e,o,r=15,s,a,l=i.EUCLIDEAN){if(t.length!==o.length||t.length!==s.length||t.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=t[0].length,d=t.map((t=>t[e])),p=Math.ceil(u/this._workerCount);for(let e=0;e<this._workerCount;e++)h[e]=new Promise(((n,i)=>{const h=e*p,m=e===this._workerCount-1?u:(e+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[e].postMessage({values:t.map((t=>t.slice(h,m))),target:d,fnNames:o,opts:s,nNeighbours:r,weights:a,aggregationMethod:l,startIdx:h}),c[e].onmessage=({data:{error:t,knnDistances:o,knnIndexes:r}})=>{t?(c[e].terminate(),i(t)):(c[e].terminate(),n({knnDistances:o,knnIndexes:r}))}}));const m=await Promise.all(h),f={knnDistances:new Array(r).fill(99999),knnIndexes:new Array(r).fill(-1)};for(const t of m)for(let e=0;e<(t.knnDistances?.length??0);++e)F(f.knnDistances,f.knnIndexes,t.knnDistances[e],t.knnIndexes[e]);return f}async multiColumnKNN(t,e,o=15,r,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==r.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:r,nNeighbours:o,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:o}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:o}))}}));const d=await Promise.all(h),p={knnDistances:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(99999))),knnIndexes:new Array(t[0].length).fill(null).map((()=>new Array(o).fill(-1)))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)F(p.knnDistances[n],p.knnIndexes[n],e.knnDistances[n][t],e.knnIndexes[n][t]);return p}async getSampleDistances(t,e,o=[],r,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=t[0].length*(t[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:t,startIdx:d,endIdx:p,sampleLength:h,fnNames:e,opts:o,weights:r,aggregationMethod:s}),a[l].onmessage=({data:{error:t,distance:e}})=>{a[l].terminate(),t?u(t):c({distance:e})}}));const d=await Promise.all(u),p=d.reduce(((t,e)=>t+e.distance.length),0),m=new Float32Array(p);let f=0;for(const t of d)m.set(t.distance,f),f+=t.distance.length;return m.sort(),m}catch(t){return a?.forEach((t=>t?.terminate())),console.error(t),new Float32Array(1).fill(.5)}}async getMinimalThreshold(t,e,n=[],o,r=i.EUCLIDEAN){try{const i=t.length*(t.length-1)/2,s=await this.getSampleDistances(t,e,n,o,r);return 1-s[Math.floor(7e7/i*s.length)]}catch(t){return console.error(t),.5}}static calcSync(t,e,n,i){const o=[],r=[],s=[];let a=0,l=0,c=0;const h=t.length*(t.length-1)/2;for(;a<h;){const e=G(t[l])||G(t[c])?1:n(t[l],t[c]);1-e>=i&&(o.push(l),r.push(c),s.push(e)),a++,c++,c===t.length&&(l++,c=l+1)}return{i:new Int32Array(o),j:new Int32Array(r),distance:new Float32Array(s)}}}var V,W,U=n(8774);(W=V||(V={})).none="none",W.bold="bold",W.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(t){t!==this._currentLineIdx&&(this._currentLineIdx=t,this.sp.render(this.ctx))}set linesToRender(t){this.updateLines(t),this.sp.render(this.ctx)}set linesVisibility(t){this.visibility=t,this.sp.render(this.ctx)}constructor(t,e,n,i,o=V.none){var r;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=t,this.xAxisCol=this.sp.dataFrame.columns.byName(e),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=o,this.updateLines(i),this.visibility=null!==(r=i.visibility)&&void 0!==r?r:new U.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=t=>{var e;(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(t.offsetX,t.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},this.canvas.onmousemove=t=>{var e;this.mouseOverLineId=(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)?-1:this.checkCoordsOnLine(t.offsetX,t.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},t.onEvent("d4-before-draw-scene").subscribe((t=>{this.renderLines()}))}updateLines(t){this.lines=t,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),t.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var t,e,n,i,o,r,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(t=this.lines.width)&&void 0!==t?t:1,this.ctx.strokeStyle=`rgba(${null!==(e=this.lines.color)&&void 0!==e?e:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let t=0;t<this.lines.from.length;t++)if(b.get(this.lines.from[t])&&b.get(this.lines.to[t])&&this.visibility.getBit(t)){let e=0;const n=this.sp.getMarkerSize(this.lines.from[t])/2,i=this.sp.getMarkerSize(this.lines.to[t])/2,b=this.sp.pointToScreen(this.lines.from[t]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[t]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const e=(null===(o=this.lines.colors)||void 0===o?void 0:o[t])?null===(r=this.lines.colors)||void 0===r?void 0:r[t]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[t])?null===(l=this.lines.opacities)||void 0===l?void 0:l[t]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${e},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[t])?null===(u=this.lines.widths)||void 0===u?void 0:u[t]:null!==(d=this.lines.width)&&void 0!==d?d:1}t===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[t];let A=null;if(b){e=this.getLineLength(w,C,S,x);const o=this.getPointOnDistance(w,C,S,x,i,e),r=this.getPointOnDistance(S,x,w,C,n,e);w=o.x,C=o.y,S=r.x,x=r.y,A=this.lines.from[t]>this.lines.to[t]?this.findControlPoint(b,w,C,S,x,t):this.findControlPoint(b,S,x,w,C,t),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(t))&&(e||(e=this.getLineLength(w,C,S,x)),e>this.arrowWidth)){const t=b?null:this.getPointOnDistance(w,C,S,x,i,e),n=b?A.x:w,o=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==t?void 0:t.x)&&void 0!==f?f:w,null!==(g=null==t?void 0:t.y)&&void 0!==g?g:C,n,o)}this.ctx.stroke(),this.ctx.closePath(),t===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(t){switch(this.currentLineStyle){case V.bold:t?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:t?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const t=new Path2D;t.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(t),this.ctx.closePath()}createMultiLinesIndices(){const t={};for(let e=0;e<this.lines.from.length;e++){let n=0,i=0;this.lines.from[e]<this.lines.to[e]?(n=this.lines.from[e],i=this.lines.to[e]):(n=this.lines.to[e],i=this.lines.from[e]),t[`${n}|${i}`]?(1===t[`${n}|${i}`].length&&(this.multipleLinesCounts[t[`${n}|${i}`][0]]=1,t[`${n}|${i}`].push(1)),this.multipleLinesCounts[e]=++t[`${n}|${i}`][1]):t[`${n}|${i}`]=[e]}}checkCoordsOnLine(t,e){let n=-1,i=null,o=null;const r=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(r.get(this.lines.from[s])&&r.get(this.lines.to[s])&&this.visibility.getBit(s)){const r=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,r,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);o=this.calculateDistToCurveLine(s,t,e,i,h,u)}else o=this.calculateDistToStraightLine(t,e,l,c);(!i&&null!==o&&o<5||i&&null!==o&&o<i)&&(i=o,n=s)}return n}calculateDistToStraightLine(t,e,n,i){const o=Math.min(n.x,i.x),r=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return t>=o-2&&t<=r+2&&e>=s-2&&e<=a+2?this.distToStraightLineSegment(t,e,n,i):null}distToStraightLineSegment(t,e,n,i){const o=(t,e,n,i)=>Math.pow(t-n,2)+Math.pow(e-i,2),r=o(n.x,n.y,i.x,i.y);if(0==r)return o(t,e,n.x,n.y);let s=((t-n.x)*(i.x-n.x)+(e-n.y)*(i.y-n.y))/r;return s=Math.max(0,Math.min(1,s)),o(t,e,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(t,e,n,i,o,r){const s=Math.min(i.x,o.x,r.x),a=Math.max(i.x,o.x,r.x),l=Math.min(i.y,o.y,r.y),c=Math.max(i.y,o.y,r.y);if(e>=s-2&&e<=a+2&&n>=l-2&&n<=c+2){const t=a-s,h=c-l;return this.calculateDistToCurveInRect(e,n,i,r,o,t,h)}return null}calculateDistToCurveInRect(t,e,n,i,o,r,s){const a=Math.floor((r+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new U.A(a);for(let r=0;r<c.length;r++){const s=r*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*o.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*o.y,m=Math.abs(t-a),f=Math.abs(e-p),g=m+f;(!d||d>g)&&(d=g),u[r]=Math.max(m,f),c[r]=a,h[r]=p}for(let t=0;t<c.length;t++)u[t]<d&&p.setBit(t,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-t,h[n]-e);(!m||m>i)&&(m=i)}return m}getLineLength(t,e,n,i){return Math.sqrt(Math.pow(n-t,2)+Math.pow(i-e,2))}getPointOnDistance(t,e,n,i,o,r){const s=n-o*((n-t)/r),l=i-o*((i-e)/r);return new a.Point(s,l)}findControlPoint(t,e,n,i,o,r){const s=e+(i-e)/2,l=n+(o-n)/2;let c=s-e,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(t/2);return t%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(t,e,n,i,o){const r=Math.atan2(i-e,o-n)+Math.PI;t.moveTo(e-this.arrowWidth*Math.sin(r-Math.PI/10),n-this.arrowWidth*Math.cos(r-Math.PI/10)),t.lineTo(e,n),t.lineTo(e-this.arrowWidth*Math.sin(r+Math.PI/10),n-this.arrowWidth*Math.cos(r+Math.PI/10))}}var q,z,Y=n(8060),K=n(3629);async function Z(t,e,i,o,s,a,l){let c=await async function(t,e,i,o,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==a.distanceFnArgs.length||t.length!==o.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:t,distanceMetrics:e,method:i,options:a,weights:o,aggregationMethod:s});const d=r.events.onCustomEvent(Y.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:i}})=>{G(n)||G(i)?(d.unsubscribe(),t?h(t):c(e),setTimeout((()=>u.terminate()),100)):l&&l(n,i,e)}}))}(t,i,e,o,s,a,l);return c=c.map((t=>(0,K.S8)(t))),c}(z=q||(q={})).EUCLIDEAN="EUCLIDEAN",z.MANHATTAN="MANHATTAN";const X={[q.EUCLIDEAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[q.MANHATTAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var J,Q;(Q=J||(J={})).HAMMING="Hamming",Q.EUCLIDEAN="Euclidean",Q.VECTOR_COSINE="Vector Cosine",Q.MANHATTAN="Manhattan",Q.TANIMOTO="Tanimoto",Q.LEVENSTEIN="Levenshtein",Q.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Q.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Q.SOKAL="Sokal",Q.COSINE="Cosine",Q.ASYMMETRIC="Asymmetric",Q.Difference="Difference",Q.OneHot="One-Hot";const tt={[J.HAMMING]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[J.EUCLIDEAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[J.MANHATTAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[J.VECTOR_COSINE]:function(t,e){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[J.TANIMOTO]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[J.LEVENSTEIN]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[J.NEEDLEMAN_WUNSCH]:function(t,e){return`\n      let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${t+1}u>;\n      var horizontalGaps: array<u32, ${t+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${e};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${e};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${e}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[J.MONOMER_CHEMICAL_DISTANCE]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${e}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[J.SOKAL]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[J.COSINE]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[J.ASYMMETRIC]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[J.Difference]:function(t,e){return`\n    let range = suppInfo.range${e};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[J.OneHot]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},et={[J.HAMMING]:t=>Math.ceil(t/30),[J.EUCLIDEAN]:t=>Math.ceil(t/30),[J.MANHATTAN]:t=>Math.ceil(t/30),[J.TANIMOTO]:t=>Math.ceil(t/30),[J.SOKAL]:t=>Math.ceil(t/30),[J.COSINE]:t=>Math.ceil(t/30),[J.ASYMMETRIC]:t=>Math.ceil(t/30),[J.LEVENSTEIN]:t=>Math.ceil(t*t/60),[J.NEEDLEMAN_WUNSCH]:t=>Math.ceil(t*t/60),[J.MONOMER_CHEMICAL_DISTANCE]:t=>Math.ceil(t/25),[J.Difference]:t=>1,[J.OneHot]:t=>Math.ceil(t/40),[J.VECTOR_COSINE]:t=>Math.ceil(t/30)},nt={STRING:new Set([J.HAMMING,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.MONOMER_CHEMICAL_DISTANCE,J.OneHot]),UINT32ARRAY:new Set([J.HAMMING,J.EUCLIDEAN,J.MANHATTAN,J.MONOMER_CHEMICAL_DISTANCE,J.LEVENSTEIN,J.NEEDLEMAN_WUNSCH,J.TANIMOTO,J.COSINE,J.VECTOR_COSINE,J.SOKAL,J.ASYMMETRIC,J.OneHot,J.Difference]),INT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.OneHot,J.Difference,J.VECTOR_COSINE]),FLOAT32ARRAY:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference,J.VECTOR_COSINE]),NUMBER:new Set([J.EUCLIDEAN,J.MANHATTAN,J.Difference]),BITARRAY:new Set([J.TANIMOTO,J.COSINE,J.SOKAL,J.ASYMMETRIC])};var it=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function ot(t,e,n,i){return t.map(((t,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${tt[t](e[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${t.length}>;\n        ${t.map(((t,e)=>`distances[${e}] = distanceScript${e}(aIndex, bIndex);`)).join("\n")}\n        ${X[i](t.length)}\n      }\n    \n    `}let rt=0;const st="cliffsDf",at=new h.Subject,lt="Δ activity",ct="SALI",ht="Similarity",ut="line index",dt=["From","To"],pt="filterCliffs";async function mt(t,e,i,o,l,c,h,u,d,p,m,f,g,y,b,v,w){rt++;const C=c/100;let A,S=!1;const x=f.inputs,_=await f.apply({[x[0].name]:e,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let I=[];if(u===N){const e=await function(t,e,i,o,r,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:t,threshold:e,weights:i,aggregationMethod:o,distanceFns:r,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((t,e)=>{u=t,h.onmessage=e=>{setTimeout((()=>h.terminate()),100),t(e.data.res)},h.onerror=t=>{setTimeout((()=>h.terminate()),100),e(t)}})),terminate:()=>{try{u(null),h.terminate()}catch(t){console.error(t)}}}}([_.entries],c,[1],"MANHATTAN",[h],[_.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;t.columns.addNewInt(t.columns.getUnusedName("MCL Cluster")).init((t=>e.clusters[t])),I=[e.embedX,e.embedY]}else I=await 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t))?(s="BITARRAY",t.map((t=>t._data))):t.some((t=>t instanceof Float32Array))?(s="FLOAT32ARRAY",t):t.some((t=>t instanceof Uint32Array))?(s="UINT32ARRAY",t):t.some((t=>t instanceof Int32Array))?(s="INT32ARRAY",t):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((t=>t.length)));if(!nt[s]||!nt[s].has(e))throw new Error(`Distance metric '${e}' not supported for entry type '${s}'`);const h=c.reduce(((t,e)=>Math.max(t,e)),0),u=et[e](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach(((t,e)=>{p.set(t,e*h)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(e===J.NEEDLEMAN_WUNSCH||e===J.MONOMER_CHEMICAL_DISTANCE){let t=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((t,e)=>Math.max(t,e.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let e=0;e<p.length;e++)p[e]>t&&(t=p[e]);i.scoringMatrix=new Array(t+1).fill(null).map((()=>new Array(t+1).fill(0))),i.alphabetIndexes={};for(let t=0;t<i.scoringMatrix.length;t++)i.scoringMatrix[t][t]=1,i.alphabetIndexes[String.fromCharCode(t)]=t}const e=(t+1)*(t+1),s=new Array(t+1).fill(null).map((()=>new Float32Array(t+1)));for(let e=0;e<t+1;e++)s[e][e]=1;const a=i.alphabetIndexes;for(const t of Object.keys(a))for(const e of Object.keys(a))t!==e&&(s[t.charCodeAt(0)][e.charCodeAt(0)]=i.scoringMatrix[a[t]][a[e]]);f=2+e,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(o=i.gapOpenPenalty)&&void 0!==o?o:1,y[1]=null!==(r=i.gapExtensionPenalty)&&void 0!==r?r:.6;let l=2;for(let t=0;t<s.length;t++)y.set(s[t],l),l+=s[t].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${t+1}>, ${t+1}>`}else if(e===J.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const t=p.reduce(((t,e)=>Math.min(t,e)),p[0]),e=p.reduce(((t,e)=>Math.max(t,e)),p[0]);i.range=e-t}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(t,n[e],e,r[e])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=q.MANHATTAN);let d=u.map((t=>t.suppInfoStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((t=>t.dataStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((t,e)=>{f.set(t.arraySizes,e*h)}));const g=1e4,y=100,b=u.reduce(((t,e)=>t+e.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${S} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${ot(n,u.map((t=>t.maxEntryLen)),l,i)}\n\n\n    `}),_=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),I=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),$=Math.floor(A/g);let R=0,k=1;console.time("GPUthreadStarts");for(let t=0;t<g;t++){const e=9999===t?A-1:(t+1)*$,n=h-2-Math.floor(Math.sqrt(-8*e+4*h*(h-1)-7)/2-.5),i=e-h*n+Math.floor((n+1)*(n+2)/2);I[t]=k,L[t]=R,N[t]=i,P[t]=n,R=n,k=i}console.timeEnd("GPUthreadStarts");const O=4e4+h*c+c+u.reduce(((t,e)=>t+e.sourceArraySize),0),H=u.reduce(((t,e)=>t+e.suppInfoSize),0),G=1e6,F=O*Uint32Array.BYTES_PER_ELEMENT;let D=F;const B=15&F;0!==B&&(D+=16-B);const V=s.createBuffer({label:"compute info buffer",size:D,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=V.getMappedRange();let U=0;new Uint32Array(W,U,g).set(I),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(L),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(N),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,g).set(P),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,U,f.length).set(f),U+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,U,c).set(o),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const t of u){const e=t.EncodedArrayConstructor,n=t.sourceArraySize;new e(W,U,n).set(t.flatSourceArray),U+=n*e.BYTES_PER_ELEMENT}V.unmap();const j=H*Uint32Array.BYTES_PER_ELEMENT;let z=j;const Y=15&j;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info 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t=s.createCommandEncoder({label:"distance encoder"}),e=t.beginComputePass({label:"distance compute pass"});e.setPipeline(_),e.setBindGroup(0,st),e.dispatchWorkgroups(w,w),e.end(),t.copyBufferToBuffer(rt,0,at,0,at.size);const n=t.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield at.mapAsync(GPUMapMode.READ);const i=at.getMappedRange();let o=0;const r=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,o,G);o+=G*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,o,G);o+=G*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,o,g);o+=g*Uint32Array.BYTES_PER_ELEMENT,ut=new Uint32Array(i,o,g).every((t=>1===t));const h=c.reduce(((t,e)=>t+e),0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let t=0;t<c.length;t++){const e=c[t];0!==e&&(u.set(r.subarray(t*y,t*y+e),m),d.set(a.subarray(t*y,t*y+e),m),p.set(l.subarray(t*y,t*y+e),m),m+=e)}lt.push(u),ct.push(d),ht.push(p),at.unmap()}const dt=lt.reduce(((t,e)=>t+e.length),0),pt=new Uint32Array(dt),mt=new Uint32Array(dt),ft=new Float32Array(dt);let gt=0;for(let t=0;t<lt.length;t++)pt.set(lt[t],gt),mt.set(ct[t],gt),ft.set(ht[t],gt),gt+=lt[t].length;return V.destroy(),K.destroy(),rt.destroy(),at.destroy(),{i:pt,j:mt,distance:ft}}))}([_.entries],C,[h],q.MANHATTAN,[1],[_.options??{}])}catch(t){console.error(t)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new B).calc(_.entries,h,C,_.options));const P=await async function(t,e){const n=t.distance.map(((n,i)=>{const o=Math.abs(e.get(t.i[i])-e.get(t.j[i]));return 0!=n?o/n:1/0})),i=t.distance.map((t=>1-t)),o=t.i,r=t.j,s=a.BitSet.create(e.length);return t.distance.forEach(((e,n)=>{s.set(t.i[n],!0),s.set(t.j[n],!0)})),{simVals:i,saliVals:n,n1:o,n2:r,cliffsBitSet:s}}(L,l),R=function(t,e,n,i,o,r,s){const l=new Array(t).fill(0);for(let t=0;t!=i.length;++t)n[t]!=1/0&&(s.get(i[t])>s.get(o[t])?l[i[t]]+=n[t]:l[o[t]]+=n[t]);return a.Column.fromList("double",e,l)}(e.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);t.columns.add(R);const k=P.cliffsBitSet,H=function(t){const e=t.filter((t=>t!==1/0)),n=e.reduce(((t,e)=>Math.min(t,e)),Number.MAX_VALUE);return{max:e.reduce(((t,e)=>Math.max(t,e)),n),min:n}}(P.saliVals),G=.8/(H.max-H.min),F=r.shell.getTableView(t.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:R.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:o}),W=function(t,e,n,i,o,r,s,l){const c={from:new Uint32Array(e.n1.length),to:new Uint32Array(e.n1.length),opacities:new Float32Array(e.n1.length),colors:new Array(e.n1.length),widths:new Float32Array(e.n1.length)};for(let n=0;n<e.n1.length;n++)c.from[n]=e.n1[n],c.to[n]=e.n2[n],c.opacities[n]=e.saliVals[n]===1/0?1:.2+(e.saliVals[n]-s.min)*l,c.colors[n]=t.selection.get(c.from[n])&&t.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return dt.forEach(((t,e)=>{h.columns.addNewString(t).init((t=>n.get(0===e?c.from[t]:c.to[t]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(h.col(t),r),h.col(t).semType=o})),h.columns.addNewFloat(lt).init((t=>Math.abs(i.get(c.from[t])-i.get(c.to[t])))),h.columns.addNewInt(ut).init((t=>t)),h.columns.addNewFloat(ct).init((t=>e.saliVals[t])),h.columns.addNewFloat(ht).init((t=>e.simVals[t])),h.name=`${st}${rt}`,{lines:c,linesDf:h}}(t,P,e,l,p,m,H,G);W.lines.skipMultiLineCalculation=!0,W.linesDf.col(ct).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(D,i[0],i[1],W.lines,V.none),z=b?b(W.linesDf,dt).sort([ct],[!1]):W.linesDf.plot.grid().sort([ct],[!1]);z.col(ut)&&(z.col(ut).visible=!1),t.temp[".cliffsDfGrid"]=z;const Y=s.button(`${W.linesDf.rowCount} cliffs`,(()=>{const t=$()(F.viewers).some((t=>t.dataFrame.name===`${st}${rt}`));w&&!t&&F.addViewer(z),F.dockManager.dock(z,"down",null,"Activity cliffs",v??.2)}));Y.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:e=>{e?(D.dataFrame.setTag(pt,i[0]),t.filter.and(k),at.next(i[0])):(D.dataFrame.setTag(pt,""),t.filter.setAll(!0),at.next(""))}});D.root.prepend(s.divH([Y,K.root],"cliffs_div")),at.subscribe((t=>{K.enabled=""===t||t===i[0]})),t.onRowsFiltering.subscribe((()=>{K.value&&t.filter.and(P.cliffsBitSet)}));const X=r.events.onViewerClosed.subscribe((t=>{t.args.viewer===D&&(F.dockManager.close(z.root),X.unsubscribe(),F.subs=F.subs.filter((t=>t!==X)))}));return F.subs.push(X),W.linesDf.onCurrentCellChanged.subscribe((()=>{for(let t=0;t<W.linesDf.rowCount;t++)W.lines.widths[t]=t===W.linesDf.currentRowIdx?3:1;U.linesToRender=W.lines;const n=W.linesDf.currentCol&&W.linesDf.currentCol.name===dt[1]?W.lines.to:W.lines.from,o=-1!==W.linesDf.currentRowIdx?W.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=o?n[o]:-1,null!==o){const n=W.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(t,e,n,i,o,r){const s=Math.abs(n-o),a=Math.abs(i-r),l=t/s,c=e/a,h=Math.min(l,c),u=t/h*5,d=e/h*5,p=(n<o?n:o)+s/2-u/2,m=(i>r?i:r)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],W.lines.from[n]),D.dataFrame.get(i[1],W.lines.from[n]),D.dataFrame.get(i[0],W.lines.to[n]),D.dataFrame.get(i[1],W.lines.to[n]));D.zoom(a,h,c,u),K.value?t.filter.and(k):!0===K.enabled&&t.filter.setAll(!0),setTimeout((()=>{!function(t,e,n,i,o,a,l,c,h){const u=e.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:o,df:t,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{r.shell.o=e.root}),500)}(t,A,W.lines.from[o],W.lines.to[o],o,e,l,W.linesDf.get(ct,o),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(e.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),W.linesDf.onSelectionChanged.subscribe((e=>{setTimeout((()=>(()=>{const e=a.BitSet.create(t.rowCount);for(let t=0;t<W.linesDf.rowCount;t++){const n=W.linesDf.selection.get(t);n&&(e.set(W.lines.from[t],!0),e.set(W.lines.to[t],!0)),W.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),U.linesToRender=W.lines})()),100)})),t.onSelectionChanged.subscribe((e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(S?S=!1:(t=>{t.selection.setAll(!1);for(let t=0;t<W.lines.colors.length;t++)W.lines.colors[t]="0,128,0";U.linesToRender=W.lines})(z.dataFrame))})),U.lineClicked.subscribe((e=>{if(S=!0,U.currentLineId=e.id,-1!==e.id){const n=W.linesDf.selection.clone();setTimeout((()=>{e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),W.linesDf.selection.copyFrom(n)):(W.linesDf.currentRowIdx!==e.id&&(W.linesDf.currentRowIdx=e.id,t.currentRowIdx=W.lines.from[e.id]),W.linesDf.selection.copyFrom(n));const i=W.linesDf.getSortedOrder(z.sortByColumns,z.sortTypes);z.scrollToCell(dt[0],i.indexOf(e.id))}),500)}})),U.lineHover.pipe((0,O.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===t.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[W.lines.from[n.id],W.lines.to[n.id]],df:t,seqCol:e,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const t=s.accordion(),e=s.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(s.span([e,s.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),r.shell.o=t.root,t}(),D}var ft,gt=n(2003),yt=n(3516),bt=n(6718),vt=n(3077),wt=n(439);!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(ft||(ft={}));var Ct=n(9192);class At{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class St extends k{constructor(t={}){super({...t,enableMCL:!0});const e=Array.from(this.tableInput.value.columns.numericalNoDateTime);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:e.length?e[0]:null,filter:t=>e.includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new At}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const t=Array.from(this.tableInput.value.columns.numerical);this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:t.length?t[0]:null,filter:e=>t.includes(e)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(t){super.applyInput(t),this.activitiesInput.value=this.tableInput.value.col(t.activityCol),this.similarityInput.value=t.simThreshold}}var xt,Et,Tt,Mt=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function _t(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function It(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map((t=>t.name)).join(", ")})`}n(5540),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(xt||(xt={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(Et||(Et={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(Tt||(Tt={})),Object.prototype.toString;var Lt=n(6873),Nt=n(4356),Pt=n(6717),$t=n(4870),Rt=n(3856),kt=n(6882),Ot=n(7278),Ht=n(5553),Gt=n(6642),Ft=n(3599),Dt=n(673),Bt=n(8312);class Vt extends Gt.sD{monomerLib=null;seqHelper=null;constructor(t,e){super(t,e,io.logger),(0,bt.pj)().then((t=>{this.monomerLib=t.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Bt.Q)().then((t=>{this.seqHelper=t,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var Wt=n(4139);const Ut=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class jt extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(t){this.seqHandler.column.set(this.rowIdx,t)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===wt.YI.DNA}isRna(){return this.seqHandler.alphabet===wt.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===wt.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(t,e){if(null==e.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=e.column.dataFrame.cell(t,e.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=t,this.seqHandler=e}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const t=(0,Ot.qp)(this.helm),e=[],n=/\(|\)/;for(let i=0;i<t.length;i++){const o=t.getOriginal(i),r=o.split(n).filter((t=>!!t));3===r.length?(e.push(r[0]),e.push(r[1]),e.push(r[2])):e.push(o)}return new Ot.Mu(e,this.seqHandler.defaultGapOriginal)}}const qt=gt.zS;function zt(t){const e=!$().enumerate(t).some((([e,n])=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";for(const[e,o]of $().enumerate(t)){let r=e;o<t.length&&(r+=`${e?"":"-"}${i}`),n.push(r)}return[n,e]}class Yt extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=io.seqHelper}getRendererBack(t){const[e,n,i]=(0,Gt.BG)(t);if(n.meta.units!==gt.Hi.CUSTOM)return i.rendererBack;let o=null;return this.seqHelper&&(o=this.seqHelper.getSeqHandler(n).getRendererBack(e,n)),o}onClick(t,e){if(t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate(),t.cell.column.meta.units===gt.Hi.CUSTOM){const n=this.getRendererBack(t);n?.onClick(t,e)}}onMouseEnter(t,e){const n=this.getRendererBack(t);n?.onMouseEnter(t,e),this.hasMouseOver=!0}onMouseMove(t,e){const n=this.getRendererBack(t);n?.onMouseMove(t,e)}onMouseLeave(t,e){if((0,Ht.WN)(t,null),t?.grid){const e=t.grid.onEvent("d4-grid-show-tooltip").subscribe((t=>{e.unsubscribe(),this.hasMouseOver&&t.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(t,e){const n=this.getRendererBack(t);n?.onDoubleClick(t,e)}onKeyDown(t,e){const n=this.getRendererBack(t);n?.onKeyDown(t,e)}onKeyPress(t,e){const n=this.getRendererBack(t);n?.onKeyPress(t,e)}renderInt(t,e,n,i,o,r,s){const[a,l,c]=(0,Gt.BG)(r);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(io.properties?io.properties.maxMonomerLength:4)??50;if(Rt.gp.maxMonomerLength in l.tags){const t=parseInt(l.getTag(Rt.gp.maxMonomerLength));d=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in h){const t=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(t)&&t?t:50}let p=c.rendererBack;p||(p=c.rendererBack=new kt.Jy(a,l,io.logger,d,(()=>{const{font:t,fontWidth:e}=kt.Jy.getFontSettings(l);return{font:t,fontCharWidth:e,separatorWidth:u.isMsa()?8:0,monomerToShort:qt}})),l.temp[".mm.cellRenderer.settingsChanged"],Dt.s.true,p.init().then((()=>{}))),p.render(t,e,n,i,o,r,s)}render(t,e,n,i,o,r,s){if(r.cell.column?.meta?.units!==gt.Hi.CUSTOM)this.renderInt(t,e,n,i,o,r,s);else{const a=this.getRendererBack(r);a?.render(t,e,n,i,o,r,s)}}}class Kt extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){const a=window.devicePixelRatio,l=r.grid,c=r.cell.value??"",h=this.tableCol.tags[gt.gp.separator],u=this.tableCol.meta.units;i=(0,kt.U0)(l,t,e,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ut.notationProvider]?.separatorSplitter??(0,Ot.Iv)(u,h),f=m(d),g=m(p),y=$().count(0).take(f.length).map((t=>f.getCanonical(t))).toArray(),b=$().count(0).take(g.length).map((t=>g.getCanonical(t))).toArray(),v=this.tableCol.getTag(gt.gp.alphabet);Xt(t,e,n,i,o,y,b,v===gt.YI.RNA||v===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new Kt(e,n)),o}}class Zt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Wt.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,o,r,s){Kt.getOrCreate(r).render(t,e,n,i,o,r,s)}}function Xt(t,e,n,i,o,r,s,a,l,c,h){if(r.length!==s.length){const t=function(t,e){let n=0,i=0;const o=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)o[t]===r[t]&&n++;const s=o.length-r.length;for(let t=o.length-1;t>s;t--)o[t]===r[t-s]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill(wt.b9[gt.Hi.FASTA]);function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l($()(e).toArray()):t=l($()(t).toArray()),{subParts1:t,subParts2:e}}(r,s);r=t.subParts1,s=t.subParts2}const u=t.measureText(zt(r).join("")),d=t.measureText(zt(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*r.length,t.canvas.width=p+4*r.length);let m=Math.max(e,e+(i-(p+4*r.length))/2)+5;const f=Math.max(n,n+(o-28)/2);t.save();try{t.beginPath(),t.rect(e,n,c?p+4*r.length:i,o),t.clip(),t.font="12px monospace",t.textBaseline="top";const u=7;for(let e=0;e<r.length;e++){const n=r[e],c=s[e];let d=kt.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let r=kt.S$;l&&(r=l.getMonomerTextColor(a,c));const s=(0,Rt.oZ)(t,n,m,f-u,i,o,{color:d,pivot:0,left:!0}),p=(0,Rt.oZ)(t,c,m,f+u,i,o,{color:r,pivot:0,left:!0});m=Math.max(p,s),h&&(h[e]=Jt(n,c,d,r,f,u,o))}else m=(0,Rt.oZ)(t,n,m,f,i,o,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{t.restore()}}function Jt(t,e,n,i,o,r,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(zt([t]).join("")).width,h=l.measureText(zt([e]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Rt.oZ)(l,t,0,o-r,u,s,{color:n,pivot:0,left:!0}),(0,Rt.oZ)(l,e,0,o+r,u,s,{color:i,pivot:0,left:!0}),a}var Qt,te=n(8070),ee=n(4326);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(Qt||(Qt={}));const ne=new class{constructor(){this.regionTypes=[Qt.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ee.fH.Entropy,this.filterSource=ee.Fo.filterSource}};var ie=n(7602),oe=n(250);const re=Qt;var se,ae;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(se||(se={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(ae||(ae={}));const le=ne;class ce extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ae.skipEmptyPositions,le.skipEmptyPositions,{category:se.DATA}),this.regionTypes=this.stringList(ae.regionTypes,le.regionTypes,{category:se.DATA,choices:Object.values(re).filter((t=>t!=re.Unknown))}),this.chains=this.stringList(ae.chains,le.chains,{category:se.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ae.fitWidth,le.fitWidth,{category:se.LAYOUT}),this.positionWidth=this.float(ae.positionWidth,le.positionWidth,{category:se.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ae.positionHeight,le.positionHeight,{category:se.LAYOUT,choices:Object.keys(ee.fH)}),this.filterSource=this.string(ae.filterSource,le.filterSource,{category:se.BEHAVIOR,choices:Object.values(ee.lT)}),this.viewSyncer=new ie.g(io.logger)}static viewerCounter=-1;viewerId=++ce.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=`${this.viewerToLog()}.detach()`,e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),e())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case ae.regionTypes:case ae.chains:this.setData(this.regions)}switch(t.name){case ae.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ae.fitWidth:case ae.positionWidth:this.calcSize();break;case ae.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ae.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){const e=`${this.viewerToLog()}.setData()`;io.logger.debug(`${e}, in, regions.length = ${t.length}`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(t){io.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){io.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<n.length;t++)for(const o of this.chains){const r=e.find((e=>e.order==n[t]&&e.chain==o));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,o,e]})())}const o=await Promise.all(i);this.logos=new Array(n.length);for(let t=0;t<n.length;++t)this.logos[t]={};for(const[t,e,n]of o)this.logos[t][e]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(ee.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),io.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){io.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let n=0;n<this.logos.length;n++){for(const e of this.chains)this.logos[n][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[n][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,n=13,i=9,o=(this.root.clientWidth-t-(this.logos.length-1)*i-n)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const n=this.logos[t][e];n.setOptions({[oe.n5.positionWidth]:o-n.positionMarginValue}),n.root.style.width=o*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[oe.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,e=this.filterSourceInput.value;this.viewSyncer.sync(`${t}`,(async()=>{if(this.filterSource!==e){this.props.getProperty(ae.filterSource).set(this,e);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const n=this.chains[e];this.logos[t][n].setOptions({[oe.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.viewerToLog()}.invalidate(${t?` <- ${t} `:""})`;this.viewSyncer.sync(`${e}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,te.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}var he=n(6625),ue=n(6863);async function de(t,e,n="Morgan",i=1,o=.6){const r=t.length,s=io.seqHelper.getSeqHandler(t),a=Array(r);let l=1;const c=new Map,h=t.categories,u=t.getRawData();for(let e=0;e<r;e++){if(null===h[u[e]]||t.isNone(e)){a[e]=null;continue}a[e]="";const n=s.getSplitted(e);for(let t=0;t<n.length;t++){const i=n.getCanonical(t);c.has(i)||(c.set(i,String.fromCharCode(l)),l++),a[e]+=c.get(i)}}let d={};if(e===ue.Z.MONOMER_CHEMICAL_DISTANCE||e===ue.Z.NEEDLEMANN_WUNSCH){const t=Array.from(c.keys()),r=await(0,bt.A7)(t,n),s={};Object.entries(r.alphabetIndexes).forEach((([t,e])=>{s[c.get(t)]=e}));const l=a.reduce(((t,e)=>Math.max(t,e?.length||0)),0);d={scoringMatrix:r.scoringMatrix,alphabetIndexes:s,maxLength:l},e===ue.Z.NEEDLEMANN_WUNSCH&&(d.gapOpen=i,d.gapExtend=o)}return{seqList:a,options:d}}var pe=n(4954);function me(t){const e=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.points.forEach((n=>{const i=s.divText(t.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),i]))})),e}function fe(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);t.points.forEach(((e,i)=>{n[i]=t.activityCol.get(e)}));const i={},o=io.seqHelper.getSeqHandler(t.seqCol),r=o.defaultBiotype,a=ye(o.getSplitted(t.points[0]),o.getSplitted(t.points[1]),r,i);return e.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),e.append(be(i)),e.append(ge("Activity delta",Math.abs(n[0]-n[1]))),e.append(ge("Cliff",t.sali)),e}function ge(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function ye(t,e,n,i){const o=document.createElement("canvas"),r=o.getContext("2d");o.height=30;const s=io.monomerLib;return Xt(r,0,0,0,30,$().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),$().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),n,s,!0,i),o}function be(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function ve(t,e){const n=a.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=t.col(e[0]).meta.units,n.setTag(gt.gp.separator,t.col(e[0]).getTag(gt.gp.separator)),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}class we extends a.JsViewer{constructor(t,e){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...e?{semType:e}:{},nullable:!1}),this.name=t,this.semType=e}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>{this.gridSelect||this.render(t)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("targetColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===this.semType&&(this.targetColumn=e)}this.debouncedRender()}}debouncedRender(t=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(t),this.debounceTimer=null}),100)}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||!this.targetColumnName||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(r.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ce extends we{distanceMetric;fingerprint;gapOpen;gapExtend;metricsProperties=["distanceMetric","fingerprint","gapOpen","gapExtend"];fingerprintChoices=["Morgan","RDKit","Pattern","AtomPair","MACCS","TopologicalTorsion"];distanceFunctionChoices=[ue.Z.NEEDLEMANN_WUNSCH,ue.Z.HAMMING,ue.Z.LEVENSHTEIN,ue.Z.MONOMER_CHEMICAL_DISTANCE];tags=[a.TAGS.UNITS,gt.gp.aligned,gt.gp.separator,gt.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;requiresSampling=!1;constructor(t,e){super(t,e),this.distanceMetric=this.string("distanceMetric",ue.Z.HAMMING,{choices:this.distanceFunctionChoices}),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.gapOpen=this.float("gapOpen",1),this.gapExtend=this.float("gapExtend",.6)}async onTableAttached(){if(super.onTableAttached(),this.dataFrame){const t=this.dataFrame.rowCount;this.preComputeDistanceMatrix=t<=1e4,this.requiresSampling=t>1e4}}needsGapPenalties(){return this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}needsFingerprint(){return this.distanceMetric===ue.Z.MONOMER_CHEMICAL_DISTANCE||this.distanceMetric===ue.Z.NEEDLEMANN_WUNSCH}}const Ae={gapPenalty:1,matchScore:1,gapSymbol:wt.b9[wt.Hi.FASTA],localAlignment:!1};class Se extends Ce{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;lastDistanceMetric="";lastFingerprint="";lastGapOpen=0;lastGapExtend=0;constructor(t,e){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.targetColumn){this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend;if(t&&!this.gridSelect||e){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(t,this.idxs.length).init((t=>this.targetColumn?.get(this.idxs?.get(t)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.targetColumn.getTag(t))));const e=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await e.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(e),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;e.onCurrentRowChanged.subscribe((t=>{n&&clearTimeout(n),(e.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=e.col("indexes").get(e.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(e)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=e,this.analysisGrid.invalidate()):(this.analysisGrid=e.plot.grid(),(0,$t.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,$t.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const o=r.shell.tv;this.subInited||(o.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}}async computeByMM(){const t=this.targetColumn.length,e=Math.min(this.limit,t-1);if(!this.knn||this.kPrevNeighbors!==e||this.lastDistanceMetric!==this.distanceMetric||this.lastFingerprint!==this.fingerprint||this.lastGapOpen!==this.gapOpen||this.lastGapExtend!==this.gapExtend){const t=this.distanceMetric,n=await de(this.targetColumn,t,this.fingerprint,this.gapOpen,this.gapExtend),i=n.seqList,o=n.options;this.lastDistanceMetric=this.distanceMetric,this.lastFingerprint=this.fingerprint,this.lastGapOpen=this.gapOpen,this.lastGapExtend=this.gapExtend,this.kPrevNeighbors=e,this.knn=await(new B).getKNN(i,t,e,o)}const n=new Array(e).fill(0).map(((t,e)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][e],score:1-this.knn.knnDistances[this.targetMoleculeIdx][e]})));n.sort(((t,e)=>e.score-t.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",e+1).init((t=>n[t].idx)),this.scores=a.Column.float("score",e+1).init((t=>n[t].score))}createPropertyPanel(t){const e=s.div(),n={},i=this.molCol?.name,o=t.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(o),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(t.currentRowIdx),u=function(t,e,n={}){const i={...Ae,...n},o=t.length,r=e.length,s=Array(o+1).fill(0).map((()=>Array(r+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<o+1;n++)for(let o=1;o<r+1;o++)s[n][o]=Math.max(0,s[n-1][o-1]+(t.getCanonical(n-1)===e.getCanonical(o-1)?i.matchScore:-i.matchScore),s[n-1][o]-i.gapPenalty,s[n][o-1]-i.gapPenalty),s[n][o]>=a&&(a=s[n][o],l=[n,o]);let c=i.localAlignment?l[0]:o,h=i.localAlignment?l[1]:r,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(t.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1)}u=[...$().count(0).take(c).map((e=>t.getCanonical(e))),...u.reverse(),...i.localAlignment?$().count(l[0]).take(o).map((e=>t.getCanonical(e))):[]],d=[...$().count(0).take(h).map((t=>e.getCanonical(t))),...d.reverse(),...i.localAlignment?$().count(l[1]).take(r).map((t=>e.getCanonical(t))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new Ot.Mu(u,i.gapSymbol),seq2Splitted:new Ot.Mu(d,i.gapSymbol)}}(c,h),d=ye(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(be(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>e),!0),r.shell.o=p.root}}class xe extends Ce{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;sampledIndices=null;constructor(t){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.targetColumn){await this.computeByMM();const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,e=a.Column.string(t,this.renderMolIds.length).init((t=>this.targetColumn?.get(this.renderMolIds[t])));e.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>e.setTag(t,this.targetColumn.getTag(t))));const n=a.DataFrame.fromColumns([e]);e.temp[".mm.cellRenderer.maxMonomerLength"]=4,n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]}));const i=n.plot.grid();(0,$t.Kd)(i,e.name,450,30),(0,$t.Ku)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByMM(){const t=this.targetColumn.length;let e;this.requiresSampling&&t>1e4?(e=this.createRandomSample(t,1e4),this.sampledIndices=e):(e=Array.from({length:t},((t,e)=>e)),this.sampledIndices=null);const n=this.distanceMetric,i=await de(this.targetColumn,n,this.fingerprint,this.gapOpen,this.gapExtend),o=i.seqList,r=i.options,s=e.map((t=>o[t])),a=new D(!0,!1),l=await a.calc(s,n,!0,r);a.terminate();const c=e.length,h=(d=c,(t,e)=>d*t+e-Math.floor((t+2)*(t+1)/2)),u=function(t,e){function n(t,e){let n=null,i=null;for(const o of t){const t=e(o);(null==i||t>i)&&(n=o,i=t)}return n}const i=[(r=t-1,Math.floor(function(t){return Math.random()*t}(r)))],o=new Set;var r;for(let e=0;e<t;++e)i.includes(e)||o.add(e);for(;i.length<e;){const t=n(o.values(),(t=>Math.min.apply(Math,i.map((function(e,n){return l[h(t,e)]})))));null!=t&&(i.push(t),o.delete(t))}return i}(c,Math.min(c,this.limit));var d;this.renderMolIds=u.map((t=>e[t]))}createRandomSample(t,e){const n=[];for(let e=0;e<t;e++)this.targetColumn.isNone(e)||n.push(e);if(n.length<=e)return n;for(let t=n.length-1;t>0;t--){const e=Math.floor(Math.random()*(t+1)),i=n[t];n[t]=n[e],n[e]=i}return n.slice(0,e)}}var Ee,Te=n(5433),Me=n(3890),_e=n(1687);!function(t){t.TYPE="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t[t.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",t.RGP_LINE_START="M  RGP",t.ATOM_ALIAS_LINE_START="A  ",t.END="M  END"}(Ee||(Ee={}));class Ie{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let n=t;const i=this.isWhitespace(n)?e:e-1;for(let t=0;t<i;t++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let n=this.getAtomBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToAtomType(n),e[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let o=0;o<this.atomCount;o++){i=this.shiftIdxToXColumn(i);for(const r of[t,e,n])r[o]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:n}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[n]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let n=this.getBondBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToBondType(n),e[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let n=e+1;for(;!this.isWhitespace(n);)++n;return t(this.fileContent.substring(e,n))}}class Le extends Ie{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,n=e;return this.isQuote(e)?(n=this.getNextIdenticalChar(e),e++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(e,n)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((n=this.fileContent.charCodeAt(e+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(n=this.shiftIdxToAtomType(n),t(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Ne extends Le{constructor(t){super(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map,e=this.fileContent.split("\n");e.filter((t=>t.startsWith(Ee.RGP_LINE_START))).forEach((e=>{const n=this.getAtomIdxToRgpIdxList(e);for(const[e,i]of n){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,i)}}));const n=e.map(((t,e)=>{if(t.startsWith(Ee.ATOM_ALIAS_LINE_START))return e})).filter((t=>void 0!==t)),i=n.map((t=>e[t])),o=n.map((t=>e[t+1]));i.forEach(((e,n)=>{const i=parseInt(e.split(/\s+/)[1])-1,r=parseInt(o[n].substring(1));if(t.has(r))throw new Error(`R group ${r} is already in the map`);t.set(r,i)}));const r=this.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==r.length)throw new Error(`Unaccounted R group indices: ${r}`);return t}getAtomIdxToRgpIdxList(t){const e=t.split(/\s+/).filter((t=>t)).slice(3).map((t=>parseInt(t))),n=new Array(e.length/2);for(let t=0;t<e.length;t+=2)n[t/2]=[e[t+1],e[t]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((t,e)=>{if(t.includes("R#"))return e})).filter((t=>void 0!==t))}static isValidMolfile(t){return-1!==t.indexOf(Ee.TYPE)&&-1!==t.indexOf(Ee.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<Ee.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,Ee.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,Ee.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+Ee.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(t,e));return t=e,e+=Ee.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class Pe extends Le{constructor(t){super(t),this.init(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map;return this.getAtomLines().forEach(((e,n)=>{const i=e.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const e=i[1].split(/\s+/).map((t=>parseInt(t)));if(e.length>2)throw new Error(`R group data ${e} has more than 2 elements`);const o=e[1];if(t.has(o))throw new Error(`R group ${o} is already in the map`);t.set(o,n)}})),t}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M  V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M  END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M  V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const n=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class $e{constructor(){}static getInstance(t){if($e.isMolfileV2K(t))return new Ne(t);if($e.isMolfileV3K(t))return new Pe(t);throw new Error("Malformed molfile")}static isMolfileV2K(t){return Ne.isValidMolfile(t)}static isMolfileV3K(t){return Pe.isValidMolfile(t)}}var Re=n(6197),ke=n(9124),Oe=n(3527);class He{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(t,e,n="missing",i=void 0,o=void 0,r=void 0,s){if(this.biotype=t,this.id=e,this.n=n,this.m=i,this.type=o,this.mt=r,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++He.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ge extends He{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(t){super(t,"*","gap")}}class Fe extends He{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(t,e){super(t,e,"ambiguous")}}class De extends He{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(t,e,n){super(t,e,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Be extends He{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(t,e){super(t,e,"broken")}}class Ve{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(t,e,n,i,o,r,s,a){this.id=t,this.m=e,this.n=n,this.na=i,this.type=o,this.mt=r,this.at=s,this.smiles=a}static fromMonomer(t,e,n){let i={};const o=e.symbol,r=e.smiles;if(e.rgroups.length>0)e.rgroups.forEach((t=>{i[t.label]=t.capGroupName}));else{if(!r){if(e.lib)return new Be(t,o);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(r)}const s=new Ve(e.symbol,e.molfile,e.name,e.naturalAnalog,e.polymerType,e.monomerType,i),a=n.getMonomerColors(t,e.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const We={[Ft.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ft.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ft.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ft.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ft.o.CHEM]:{R:"#eeeeee"},[Ft.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},Ue=/[\w()]+/,je=RegExp(String.raw`\(${Ue}(,${Ue})+\)`),qe=t=>{const e=s.canvas(250,250);return r.chem.canvasMol(0,0,250,250,e,t),e},ze=new Oe.Mi([255,255,255]),Ye=new Oe.Mi([0,0,0]),Ke=.7*(0,K.wQ)(ze);class Ze{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(t,e){this._monomers=t,this.source=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([t,e])=>0===Object.keys(e).length));for(const[t,e]of Object.entries(this._monomers))for(const[t,n]of Object.entries(e))n.lib=this}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}addMissingMonomer(t,e){let n=this._monomers[t];n||(n=this._monomers[t]={});let i=e;return e==wt._S||e===wt.b9[wt.Hi.HELM]?i="Gap":("PEPTIDE"===t&&"X"===e||"RNA"===t&&"N"===e)&&(i="Any"),n[e]={symbol:e,name:i,molfile:"",author:"MISSING",id:-1,rgroups:$().count(1).take(9).map((t=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${t.toString()}`}))).toArray(),smiles:"",polymerType:t,monomerType:void 0,createDate:null}}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?e[n]:null}else{io.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}getWebEditorMonomer(t,e){const[n,i]=(0,ke.fA)(t,e),o=(0,Re.Y)(n);let r=this.getMonomer(o,i);if(r&&n==Ft.o.LINKER&&2!=r.rgroups.length)return null;if(r&&n==Ft.o.SUGAR&&3!=r.rgroups.length)return null;r||(r=this.addMissingMonomer(o,i));let s=r.wem??null;return s||(i===wt._S||"*"==i?s=r.wem=new Ge(n):n===Ft.o.NUCLEOTIDE&&"N"===i||n===Ft.o.AA&&"X"===i||(Ft.o.CHEM,0)||je.test(i)?s=r.wem=new Fe(n,i):r.lib||(s=r.wem=new De(n,i,this.isEmpty)),s||(s=r.wem=Ve.fromMonomer(n,r,this))),s}getTooltip(t,e){const n=(0,Re.Y)(t),i=s.div([],{classes:"ui-form ui-tooltip"}),o=this.getWebEditorMonomer(t,e),r=this.getMonomer(n,e);if(r){const t=r.symbol,[e,n,a]=(r.name,o?[o.textcolor,o.backgroundcolor,o.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([t],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:e,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([r.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=r.molfile?qe(r.molfile):r.smiles?s.divV([qe(r.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),r.symbol!=wt._S){let t=r.lib?.source;t?(t.endsWith(".json")&&(t=t.substring(0,t.length-5)),t=t.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(t))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${e}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(t,e){const n=this.getMonomerColors(t,e),i=t=>{const e=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(t);if(e)return[parseInt(e[1]),parseInt(e[2]),parseInt(e[3])];const n=a.Color.fromHtml(t);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},o=i(n.textcolor),r=new Oe.Mi([...o.map((t=>t+1))]),s=(0,K.KE)(r,ze)/((0,K.wQ)(r)*(0,K.wQ)(ze)),l=i(n.backgroundcolor),c=new Oe.Mi([...l.map((t=>t+.01))]);let h;h=(0,K.KE)(c,ze)/((0,K.wQ)(c)*(0,K.wQ)(ze))<s?l:o;let u=new Oe.Mi(h);const d=(0,K.wQ)(u);return d>Ke&&(u=(0,K.dC)(Ye,u,Ke/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(t,e){const n="default";let i=n;const o=(0,Re.Y)(t),r=this.getMonomer(o,e);let s;if(r){if(r.meta&&r.meta.colors){const t=r.meta.colors;n in t||(i="default"),s=t[i]}if(!s){const e=We[t],n=e?.[r.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const e=r.naturalAnalog;if(!s&&e)return this.getMonomerColors(t,e)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(t){const e=t.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,o="";if(e)for(let t=0;t<e.length;t++)if(null!=e[t]&&/\d/.test(e[t])){i=e[t][e[t].length-1],e[t]=e[t].replace(/[0-9]/g,"");for(let n=0;n<e[t].length;n++)":"!=e[t][n]&&(o+=e[t][n]);n["R"+i]=o,o=""}return n}}var Xe=n(5488),Je={};Je.styleTagTransform=A(),Je.setAttributes=b(),Je.insert=g().bind(null,"head"),Je.domAPI=m(),Je.insertStyleElement=w(),d()(Xe.A,Je),Xe.A&&Xe.A.locals&&Xe.A.locals;class Qe extends Ze{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(t,e,n=void 0){super(t,e),this.error=n}toJSON(){const t=[];for(const e of Object.values(this._monomers))for(const n of Object.values(e))t.push({...n,lib:void 0,wem:void 0});return t}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?.[n]??null}else{io.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}_monomerSets=null;getMonomerSet(t){const e=(0,Re.Y)(t);if(this._monomerSets||(this._monomerSets={}),!(t in this._monomerSets))for(const[t,n]of Object.entries(this._monomers[e]));return this._monomerSets[t]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((n=>{e[n]=this._monomers[t][n].molfile})),e}getMonomerSymbolsByRGroup(t,e,n){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let n=e?.rgroups.length>=t;var i;return i=$e.getInstance(e.molfile).atomTypes,i.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),n&&=!0,n})),i.map((t=>t?.symbol)))}_updateLibInt(t){const e=t.getPolymerTypes(),n=this.getPolymerTypes();e.forEach((e=>{n.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((n=>{this._monomers[e][n]&&(this._duplicateMonomers[e]??={},this._duplicateMonomers[e][n]??=[this._monomers[e][n]],this._duplicateMonomers[e][n].push(t.getMonomer(e,n))),this._monomers[e][n]=t.getMonomer(e,n)}))})),this._isEmpty=this.isEmpty&&t.isEmpty}updateLibs(t,e=!1){e&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const e of t)e.error||this._updateLibInt(e);Object.entries(this.duplicateMonomers).length>0?(0,Nt.ub)().then((t=>{this.assignDuplicatePreferences(t)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(t){let e=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(t.duplicateMonomerPreferences?.[n]?.[i]){const o=t.duplicateMonomerPreferences[n][i],r=this.duplicateMonomers[n][i].find((t=>t.lib?.source===o));r?this._monomers[n][i]=r:e=!1}else e=!1;return this._duplicatesHandled=e,e}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const t={},e=this.getPolymerTypes();for(const n of e)t[n]=this.getMonomerSymbolsByType(n).length;return t}getSummaryDf(){const t=this.getPolymerTypes(),e=new Array(t.length);for(const[n,i]of $().enumerate(t))e[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",t),a.Column.fromList(a.COLUMN_TYPE.INT,"count",e)])}getSummary(){const t=this.getPolymerTypes();return 0==t.length?"empty":t.map((t=>`${t} ${this.getMonomerSymbolsByType(t).length}`)).join("\n")}static overrideCounter=0;override(t,e){return new tn(t,`override: ${++Qe.overrideCounter}, ${e}`,this)}}class tn extends Ze{data;base;constructor(t,e,n){super(t,e),this.data=t,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(t){const e=this.base.getMonomerSymbolsByType(t);for(const n of Object.keys(this.data[t]??{}))e.includes(n)||e.push(n);return e}addMissingMonomer(t,e){return this.base.addMissingMonomer(t,e)}getMonomer(t,e){const n=this.data[t]?.[e];return n??this.base.getMonomer(t,e)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(t,e,n,i,o){this.monomerLib=t,this.symbol=e,this.polymerType=n,this.monomerType=i,this.monomerLinks=o;try{this.monomers=this.monomerLinks.map((t=>{const n=this.monomerLib.getMonomer(this.polymerType,t.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=t.source)throw new Error(`Monomer '${e}' found in different library.`);return n}))}catch(t){const[e,n]=(0,Ct.AP)(t);this.error=e,this.monomers=[]}}}class nn{description;placeholders;source;error;constructor(t,e,n=void 0,i=void 0){this.description=t,this.placeholders=e,this.source=n,this.error=i}updateSets(t,e=!1){e&&(this.placeholders=[]);for(const e of t)e.error||this._updateSetInt(e)}_updateSetInt(t){for(const e of t.placeholders)this.placeholders.push(e)}}var on=n(7433),rn=n.n(on),sn=n(1913),an=n.n(sn);class ln{helmMonomerSchema;validateMonomerSchema;constructor(t){this.helmMonomerSchema=t;const e=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});an()(e),this.validateMonomerSchema=e.compile(this.helmMonomerSchema)}validateFile(t,e){const n=this.parseJson(t,e);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,e):(console.warn(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(t,e){try{return JSON.parse(t)}catch(t){return console.error(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format:`,t),null}}validateJsonContent(t,e){let n=!0;const i=new Set;for(const o of t){const t=o.symbol??o.id??o.name??"#N/A";if(n=this.validateMonomerSchema(o),!n){console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' violating JSON schema:`,o,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${e} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const r=`${o.polymerType??""}-${t}`;i.has(r)&&console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(r)}return n}}var cn=n(8604);class hn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(t,e,n,i){let o;this.fileValidator=t,this.libHelper=e,this.eventManager=n,this.logger=i;let r=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((t=>o=t))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),r||(r=!0,o())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++hn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(t,e,n){const i=await r.dapi.files.readAsText(cn.gt),o=JSON.parse(i),s=new ln(o);return new hn(s,t,e,n)}async addLibraryFile(t,e,n=!0){try{if(await r.dapi.files.exists(cn.so+`${e}`))return void r.shell.error(`File ${e} already exists`);await this.validateAgainstHELM(t,e),await r.dapi.files.writeAsText(cn.so+`${e}`,t),await this.updateValidLibList(),await r.dapi.files.exists(cn.so+`${e}`)?r.shell.info(`Added ${e} HELM library`):r.shell.error(`Failed to add ${e} library`)}catch(t){console.error(t),r.shell.error(`Failed to add ${e} library`)}}async deleteLibraryFile(t){try{await r.dapi.files.delete(cn.so+`${t}`),await this.updateValidLibList(),r.shell.info(`Deleted ${t} library`)}catch(e){console.error(e),await r.dapi.files.exists(cn.so+`${t}`)?r.shell.error(`Failed to delete ${t} library`):r.shell.warning(`File ${t} already deleted, refresh the list`)}}async loadLibraryFromFile(t,e){let n=[];const i=new a.FileSource(t),o=await i.readAsText(e);n=JSON.parse(o);const r={},s=[];return n.forEach((t=>{const e=t.polymerType,n=t.symbol;s.includes(e)||(r[e]={},s.push(e)),r[e][n]=t})),new Qe(r,e)}async loadSetFromFile(t,e,n){let i={};const o=new a.FileSource(e),r=await o.readAsText(n);i=JSON.parse(r);const s=i.description,l=Object.entries(i.placeholders).map((([e,n])=>{const i=e,o=n.polymerType,r=n.monomerType,s=n.set;return new en(t,i,o,r,s)}));return new nn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const t=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${t}, end, not changed`);for(const t of n){if(!t.endsWith(".json")){e.push(t);continue}const n=await r.dapi.files.readAsText(cn.so+`${t}`);this.isValidHELMLibrary(n,t)||e.push(t)}const i=n.filter((t=>!e.includes(t)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((t=>!t.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),e.length>0){const t=`Invalid monomer library files in ${cn.so}, consider fixing or removing them: ${e.join(", ")}`;this.logger.warning(t)}this.logger.debug(`${t}, OUT`)})),this.logger.debug(`${t}, end`),this.filesPromise}async updateValidSetList(){const t=`${this.toLog()}.updateValidSetList()`;return io.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{io.logger.debug(`${t}, IN`);const e=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void io.logger.debug(`${t}, end, not changed`);for(const t of n)t.endsWith(".json")?await r.dapi.files.readAsText(cn.Es+`${t}`):e.push(t);const i=n.filter((t=>!e.includes(t)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),io.logger.debug(`${t}, OUT`)})),io.logger.debug(`${t}, end`),this.filesPromise}libListHasChanged(t){const e=this.eventManager.getValidLibPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}setListHasChanged(t){const e=this.eventManager.getValidSetPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}async validateAgainstHELM(t,e){if(!this.isValidHELMLibrary(t,e))throw new Error(`File ${e} does not satisfy HELM standard`)}isValidHELMLibrary(t,e){return this.fileValidator.validateFile(t,e)}async getLibFileListAtLocation(){const t=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.so).then((t=>t.filter((t=>t.isFile)).map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.so.length)))}async getSetFileListAtLocation(){const t=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await r.dapi.files.list(cn.Es).then((t=>t.map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(cn.Es.length)))}}class un{constructor(){}static _instance;static getInstance(){return un._instance||(un._instance=new un),un._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((t=>{const e=this._libFilesUpdateSubject$.pipe((0,O.skip)(1)).subscribe((n=>{t(n),e.unsubscribe()}))}))}changeValidLibPathList(t){this._libFilesUpdateSubject$.next(t)}changeValidSetPathList(t){this._setFilesUpdateSubject$.next(t)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(t,e){this._librarySelectionSubject$.next([t,e])}}class dn{logger;_monomerLib=new Qe({},"MAIN");_monomerSets=new nn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(t=1/0){return t=t===1/0?6e4:t,await Promise.race([(async()=>{const t=await this.getFileManager();return await t.filesPromise,!0})(),(async()=>(await(0,te.cb)(t),!1))()]).then((e=>{if(!e)throw new Error(`Loading monomer libraries timeout ${t} ms.`)}))}constructor(t){this.logger=t}static objCounter=-1;objId=(()=>{if(++dn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return dn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(t){this._monomerLib.assignDuplicatePreferences(t)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const t=await hn.create(this,this._eventManager,this.logger);return await t.initializedPromise,t})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(t=!1){const e=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${e}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[e],i]=await Promise.all([await this.getFileManager().then((t=>[t.getValidLibraryPaths()])),(0,Nt.ub)()]),o=e.filter((t=>{const e=!i.exclude.includes(t),n=0===i.explicit.length||i.explicit.includes(t);return e&&n}));let r=0;const s=o.length,[a]=await Promise.all([Promise.all(o.map((t=>this.readLibrary(cn.so,t).catch((e=>{const n=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new Qe({},t,n)})).finally((()=>{n.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))))]);this._monomerLib.updateLibs(a,t),this._initialLoadCompleted=!0}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{n.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadLibrariesPromise}async loadLibraries(t){return this.loadMonomerLib(t)}loadSetsPromise=Promise.resolve();async loadMonomerSets(t=!1){const e=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${e}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[e]]=await Promise.all([await this.getFileManager().then((t=>[t.getValidSetPaths()]))]),n=e.filter((t=>!0));let i=0;const o=n.length,[r]=await Promise.all([Promise.all(n.map((e=>this.readSet(cn.Es,e).catch((t=>{const n=`Loading monomer sets from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new nn("Broken monomer set",[],e,n)})).finally((()=>{t.update(Math.round(100*++i/o),`Loading monomers ${i}/${o}`)})))))]);this._monomerSets.updateSets(r)}catch(t){const e=`Loading monomer sets error: ${t instanceof Error?t.message:t.toString()}`;r.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{t.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadSetsPromise}async readLibrary(t,e){const n=await this.getFileManager();return await n.loadLibraryFromFile(t,e)}async readSet(t,e){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,t,e)}async selectSpecifiedLibraries(t){const e=await this.getInvalidFileNames(t);if(e.length>0)throw new Error(`Cannot select libraries ${e}: no such library in the list`);const n=await(0,Nt.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((e=>!t.includes(e))),await(0,Nt.Eu)(n)}async getInvalidFileNames(t){const e=(await this.getFileManager()).getValidLibraryPaths();return t.filter((t=>!e.includes(t)))}async loadMonomerLibForTests(){await(0,Nt.Eu)(cn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let t=window.$monomerLibHelperPromise;return null==t&&(t=window.$monomerLibHelperPromise=(async()=>{const t=new dn(io.logger);return t._eventManager=un.getInstance(),t})()),t}}var 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Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new U.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new U.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new U.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:vn};async function Cn(t,e,n=0){if(!Object.keys(wn).includes(e))return null;const i=await async function(t){const e=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!e)return null;try{const n=(await e.apply({molString:t}))?.getBuffer().buffer;if(n)return new U.A(new Uint32Array(n),2048)}catch(t){return null}}(t);if(!i)return null;if(!wn[e])return null;const o=wn[e];let r=0,s=null;for(const[t,e]of Object.entries(o)){const o=(0,H.$1)(i,e);o>r&&o>=n&&(r=o,s=t)}return s}var An,Sn=n(857),xn={};xn.styleTagTransform=A(),xn.setAttributes=b(),xn.insert=g().bind(null,"head"),xn.domAPI=m(),xn.insertStyleElement=w(),d()(Sn.A,xn),Sn.A&&Sn.A.locals&&Sn.A.locals,function(t){t.MONOMER="Monomer",t.SYMBOL="Symbol",t.NAME="Name",t.R_GROUPS="~R-Groups",t.MONOMER_TYPE="Monomer Type",t.POLYMER_TYPE="Polymer Type",t.NATURAL_ANALOG="Natural Analog",t.AUTHOR="Author",t.CREATE_DATE="Create Date",t.ID="ID",t.META="Meta",t.SOURCE="Source"}(An||(An={}));const En={[An.MONOMER]:a.COLUMN_TYPE.STRING,[An.SYMBOL]:a.COLUMN_TYPE.STRING,[An.NAME]:a.COLUMN_TYPE.STRING,[An.R_GROUPS]:a.COLUMN_TYPE.STRING,[An.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[An.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[An.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[An.AUTHOR]:a.COLUMN_TYPE.STRING,[An.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[An.ID]:a.COLUMN_TYPE.INT,[An.META]:a.COLUMN_TYPE.STRING,[An.SOURCE]:a.COLUMN_TYPE.STRING};class Tn{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(r.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(An.NAME).width=100,this.tv.grid.col(An.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=yn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(t){this.monomerLibManamger=t,this.monomerLib=t.getBioLib(),this._newMonomerForm=new Nn(t,(()=>this.activeMonomerLib),(async t=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e,this.adjustTable(),null!=t&&setTimeout((()=>{const n=e.col(An.SYMBOL).toList().indexOf(t);-1!==n&&(this.tv?.grid.scrollToCell(e.columns.byIndex(0),n),e.currentRow=e.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.instance=new Tn(t)}return this.instance}static async getNewInstance(){const t=await dn.getInstance();return await t.awaitLoaded(),await t.loadLibrariesPromise,new Tn(t)}async createNewMonomerLib(t,e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(e.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,t),await r.dapi.files.writeAsText(cn.so+t,n),await this.monomerLibManamger.loadLibraries(!1),r.shell.v=await this.getViewRoot(t)}catch(t){r.shell.error("Error creating library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(t){const e=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const t=i(n.value);o.getButton("Create")?.classList?.toggle("d4-disabled",!!t)}});function i(t){return t&&t.trim()?t.endsWith(".json")&&e.includes(t)||e.includes(t+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const o=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const e=i(n.value);if(e)r.shell.warning(e);else{try{await this.createNewMonomerLib(function(){let t=n.value;return t.endsWith(".json")||(t+=".json"),t}(),t??[])}catch(t){r.shell.error("Error creating library"),console.error(t)}o.close()}})).show();o.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(t,e=!0){const n=await this.getMonomersDf(t);return this.tv=a.TableView.create(n,e),this.adjustTable(),this.tv.subs.push(r.events.onContextMenu.subscribe((({args:t})=>{if(!t||!t.menu||!t.context||t.context.type!==a.VIEWER.GRID||!t.context.tableView||t.context.tableView.id!==(this.tv.id??"")||!t.item||!t.item.isTableCell||(t.item.tableRowIndex??-1)<0)return;const e=t.item.tableRowIndex;t.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(e))})),t.menu.item("Fix all monomers",(()=>{this.fixAllMonomers()})),this.tv.dataFrame.selection.trueCount>0?(t.menu.item("Remove Selected Monomers",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this._newMonomerForm.removeMonomers(t,this.libInput.value)})),t.menu.item("Selection To New Library",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>On(this.tv.dataFrame.rows.get(t)))));this.createNewLibDialog(t)}))):t.menu.item("Remove Monomer",(async()=>{const t=await On(this.tv.dataFrame.rows.get(e));this._newMonomerForm.removeMonomers([t],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(r.shell.tableViews??[]).filter((t=>t.name===Tn.VIEW_NAME)).forEach((t=>t.close()))}findActiveManagerView(){if(!this.tv)return null;const t=Array.from(r.shell.tableViews??[]).find((t=>t.id===this.tv.id));return t?r.shell.v=t:Tn.closeAllMonomerManagers(),t??null}_skipLibInputOnchange=!1;async getViewRoot(t,e=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),e&&(this.tv=this.findActiveManagerView())&&(t??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),t&&(this.libInput.value=t)}catch(t){r.shell.error("Error updating library list"),console.error(t)}finally{this._skipLibInputOnchange=!1}const e=await this.getMonomersDf(t);return this.tv.dataFrame=e,this.adjustTable(),this.tv}t??=n[0],this.tv=await this.getMonomersTableView(t,e);let i=this.tv.getRibbonPanels();i.forEach(((t,e)=>{i[e]=t.filter((t=>0!==t.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((t=>t.length>0));const o=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.iconFA("wand-magic",(()=>{this.fixAllMonomers()}),"Fix all monomers"),c=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),h=s.icons.delete((async()=>{const t=this.tv?.dataFrame?.currentRowIdx??-1,e=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(t<0&&0===e.length)return;if(e.length>0){const t=await Promise.all(e.map((t=>On(this.tv.dataFrame.rows.get(t)))));return void await this._newMonomerForm.removeMonomers(t,this.libInput.value)}const n=await On(this.tv.dataFrame.rows.get(t));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(h,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const u=s.iconFA("arrow-to-bottom",(async()=>{const t=this.libInput.value;if(!t)return r.shell.error("No library selected");let e=null;try{e=await r.dapi.files.readAsText(cn.so+t)}catch(e){return r.shell.error(`Error reading library ${t}`),console.error(e)}if(!e)return r.shell.error(`Library ${t} is empty`);a.Utils.download(t,e,"text/plain")}),"Download Monomer Library");i.push([o,c,l,h,u]),this.tv.setRibbonPanels(i),this.tv.name=Tn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:t,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const t=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=t,this.adjustTable()}catch(t){console.error(t)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const d=this._newMonomerForm.form;return d.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(d,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(t){return this._newMonomer=await On(t),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(t??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(cn.so,t),!this.activeMonomerLib)return r.shell.error(`Library ${t} not found`),a.DataFrame.create();const e=this.activeMonomerLib.getPolymerTypes().flatMap((t=>this.activeMonomerLib.getMonomerSymbolsByType(t).map((e=>this.activeMonomerLib.getMonomer(t,e))))),n=a.DataFrame.create(e.length),i=new Set;for(const t of e)t.rgroups.forEach((t=>{t.label&&i.add(t.label)}));const o=Array.from(i);o.sort();for(const[t,e]of Object.entries(En))if(n.columns.addNew(t,e),t===An.R_GROUPS)for(const t of o)n.columns.addNew(t,a.COLUMN_TYPE.STRING);n.col(An.SYMBOL).semType="Monomer",n.col(An.SYMBOL).setTag(Rt.Mn.applyToBackground,"true");for(let t=0;t<e.length;t++){let i=$n(e[t].rgroups,e[t].smiles,e[t].molfile);i=Mn(i),e[t].rgroups=Ln(e[t].rgroups);const r=o.map((n=>{const i=e[t].rgroups.find((t=>t.label===n));return i?In(i,"capGroupSmiles"):""}));let s=null;if(e[t].createDate)try{s=Date.parse(e[t].createDate)}catch(n){console.error(`Error parsing date ${e[t].createDate}`)}n.rows.setValues(t,[i,e[t].symbol,e[t].name,JSON.stringify(e[t].rgroups??[]),...r,e[t].monomerType,e[t].polymerType,e[t].naturalAnalog,e[t].author,s,e[t].id,JSON.stringify(e[t].meta??{}),e[t].lib?.source??""]);try{s&&n.col(An.CREATE_DATE)?.set(t,s,!1)}catch(n){console.error(`Error setting date ${e[t].createDate}`)}}return n.col(An.MONOMER).semType=a.SEMTYPE.MOLECULE,o.forEach((t=>{n.col(t).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((async t=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;await this.editMonomer(n.rows.get(n.currentRowIdx))}catch(t){console.error(t)}})),n}catch(t){throw r.shell.error("Error creating monomers dataframe"),console.error(t),t}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async fixAllMonomers(){s.dialog("Fix All Monomers").add(s.divText("This action will fix all monomers in the library, standardize their smiles, molblocks and r-groups, assign correct natural analogs and save the library.")).add(s.divText("Do you wish to continue?")).onOK((async()=>{const t=this.tv?.dataFrame;let e=this.libInput.value;if(t&&e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=await Promise.all(new Array(t.rowCount).fill(0).map(((e,n)=>On(t.rows.get(n))))),i=JSON.stringify(n.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await r.dapi.files.writeAsText(cn.so+e,i),await this.monomerLibManamger.loadLibraries(!0),r.shell.v=await this.getViewRoot(e)}catch(t){r.shell.error("Error saving library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}else r.shell.error("No monomer library loaded")})).show()}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function Mn(t){let e=t.replaceAll(/\[R[1-9]\]/g,(t=>`[*:${t[2]}]`));return e=e.replaceAll(/\[\d\*\]/g,(t=>`[*:${t[1]}]`)),e.replaceAll(/\[\d\*\:\d\]/g,(t=>`[*:${t[1]}]`))}const _n=["alternateId","capGroupName","capGroupSMILES","label"];function In(t,e){const n=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));if(n)return t[n]}function Ln(t){return t.map((t=>{const e=function(t,e){const n={};return t.forEach((t=>{const i=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));i&&(n[t]=e[i])})),n}(_n,t),n=In(e,"capGroupSMILES"),i=In(e,"alternateId"),o=In(e,"capGroupName"),r=In(e,"label")??"R1";if(n&&i&&o||r.length<2)return e;if(i&&-1!==i.indexOf(`${r}-`)){const t=i.replace(`${r}-`,"");o||(e.capGroupName=t),n||(e.capGroupSMILES=`[*:${r.substring(1)}][${t}]`)}else o&&(n||(e.capGroupSMILES=`[*:${r.substring(1)}][${o}]`),i||(e.alternateId=`${r}-${o}`));return e})).sort(((t,e)=>t.label?.localeCompare(e.label??"")??0))}class Nn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(t){this._molChanged=t}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(t,e,n,i){this.monomerLibManager=t,this.getMonomerLib=e,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Hn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const t=this.validateInputs();t?r.shell.warning(t):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));t&&t.header.style.removeProperty("background-color");let e=this.molSketcher.getSmiles();if(!e)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();e=$n([],e);const n=this.findRgroupsInSmiles(e);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((t=>t[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((t=>Number.parseInt(t[0].match(/[1-9]/g)[0]))).map((t=>this.rgroupsGrid.items.find((e=>e.label===`R${t}`))??{capGroupSMILES:`[*:${t}][H]`,alternateId:`R${t}-H`,capGroupName:"H",label:`R${t}`}));this.rgroupsGrid.items=i.sort(((t,e)=>t.label?.localeCompare(e.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const o=await Cn(kn(e,i),this.polymerTypeInput.value??"");o&&(this.monomerNaturalAnalogInput.value=o)}catch(t){console.error(t)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const o=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new bn(o,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:t=>t?r.chem.checkSmiles(t)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:t=>t?null:"Alternate ID is required",capGroupName:t=>t?null:"Cap group name is required",label:t=>t?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new bn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const t=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=t?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(t){this.triggerMolChange=!1,this.molSketcher.setSmiles(t.smiles),this.polymerTypeInput.value=t.polymerType,this.monomerTypeInput.value=t.monomerType,this.monomerSymbolInput.value=t.symbol,this.monomerNameInput.value=t.name,this.monomerIdInput.value=t.id,this.monomerNaturalAnalogInput.value=t.naturalAnalog??null,this.rgroupsGrid.items=Ln(t.rgroups),this.metaGrid.items=Object.entries(t.meta??{}).filter((([t,e])=>"colors"!==t?.toLowerCase())).map((([t,e])=>({Property:t,Value:e}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!t.naturalAnalog&&t.polymerType&&Cn(kn(t.smiles,this.rgroupsGrid.items),t.polymerType).then((t=>{t&&(this.monomerNaturalAnalogInput.value=t)}));const e=t.meta?.colors??"";let n={};try{n=e?JSON.parse(e)?.default:{}}catch(t){console.error(t)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));if(t&&t.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const t of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==t.value||""===t.value)return`${t.caption} field is required`;let e=null;if(this.rgroupsGrid.items.length<1&&(e="At least one R-group is required"),!e)t:for(const t of this.rgroupsGrid.items)for(const[n,i]of Object.entries(t))if(!i){e=`R-group ${n} field is required for ${t.label}`;break t}return!e&&this.rgroupsGrid.hasErrors()&&(e="R-group fields contain errors"),e?(t&&t.header.style.setProperty("background-color","#ff000030"),e):null}findRgroupsInSmiles(t){return[...Array.from(t.matchAll(/\[[1-9]\*\]/g)),...Array.from(t.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const t=s.buttonsInput([this.saveButton]);return s.tooltip.bind(t,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,t],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(t){const e=$n(t.rgroups,t.smiles,t.molfile),n=r.chem.drawMolecule(e,150,150),i=s.tableFromMap({name:t.name,author:t.author,createDate:t.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(t,e,n=!0){let i=[];try{const t=await r.dapi.files.readAsText(cn.so+e);i=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const o=t.map((t=>Pn(i,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType))));for(let n=0;n<o.length;n++)if(-1===o[n])return void r.shell.error(`Monomer ${t[n].symbol} not found in library ${e}`);const a=o.map((t=>i[t])),l=s.divV(a.map((t=>this.getMonomerInfoTable(t))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((t=>t.symbol)).join(", ")} from ${e} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${e} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((t=>!a.includes(t))),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(i,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&r.shell.info(`Monomer${c?"s":""} ${a.map((t=>t.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${e} library`),u.close()})).show()}async addMonomerToLib(t,e){let n=[];try{const t=await r.dapi.files.readAsText(cn.so+e);n=JSON.parse(t)}catch(t){return r.shell.error(`Error reading library ${e}`),console.error(t)}const i=Pn(n,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType)),o=this.getMonomersDataFrame()?.col(An.MONOMER)?.toList()?.findIndex((e=>e===t.smiles)),a=async()=>{try{const i=n.findIndex((e=>e.symbol===t.symbol&&e.polymerType===t.polymerType));i>=0?n[i]={...t,lib:void 0,wem:void 0}:n.push({...t,lib:void 0,wem:void 0}),await r.dapi.files.writeAsText(cn.so+e,JSON.stringify(n,null,2)),await(await dn.getInstance()).loadLibraries(!0),await this.refreshTable(t.symbol),this._molChanged=!1,r.shell.info(`Monomer ${t.symbol} was successfully saved in library ${e}`)}catch(t){r.shell.error("Error saving monomer"),console.error(t)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${t.symbol}' already exists in library ${e}.\nAre you sure you want to overwrite it?`;else if((o??-1)>=0){const t=await On(this.getMonomersDataFrame().rows.get(o));l=this.getMonomerInfoTable(t),c=`Monomer with the same structure already exists in library ${e} with different symbol (${t.symbol}).\nAre you sure you want to duplicate it?`}if(l){const t=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{t.close(),a()})).show()}else await a()}async saveMonomer(){let t=this.molSketcher.getSmiles();if(!t||!r.chem.checkSmiles(t))return void r.shell.warning("Invalid SMILES");t=$n([],t);let e=r.chem.convert(t,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);e=Rn(e);const n={};this.metaGrid.items.filter((t=>!!t.Property&&!!t.Value)).forEach((t=>{n[t.Property]=t.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const o={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:e,smiles:t,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(o,s):r.shell.warning("Monomer library source is not specified")}}function Pn(t,e){let n=-1;for(let i=t.length-1;i>=0;i--)if(e(t[i])){n=i;break}return n}function $n(t,e,n){const i=!e||!r.chem.checkSmiles(e);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let o=i?r.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):e;return o=function(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=new RegExp(`\\[\\${t.capGroupName}:${e}\\]`,"g");n=n.replace(i,`[*:${e}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(t=>`[*:${t[1]}]`)),n}(o,t),o=Mn(o),i?o:r.chem.convert(o,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function Rn(t){const e=t.split("\n"),n=e.findIndex((t=>t.startsWith("M")&&t.includes("ISO")));if(-1!==n){const t=e[n].indexOf("ISO");e[n]=e[n].substring(0,t)+"RGP"+e[n].substring(t+3)}const i=e.findIndex((t=>t.includes("V2000")));if(-1===i)return console.error("Mol start line not found"),t;const o=Number.parseInt(e[i].trim().split(" ")[0].slice(0,3).trim()),r={};for(let t=i+1;t<i+1+o;t++){const n=e[t].indexOf("R ");if(-1===n)continue;"#"!==e[t][n+1]&&(e[t]=e[t].replace("R ","R#"));const o=e[t].trim().split(" ").map((t=>t.trim())).filter(Boolean);if(r[t-i]=1,o.length<14)continue;const s=Number.parseInt(o[13]);Number.isNaN(s)||(r[t-i]=s)}const s=Object.keys(r);if(-1===e.findIndex((t=>t.startsWith("M")&&t.includes("RGP")))){const t=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(r).map((([t,e])=>`${t.toString().padStart(4," ")}${e.toString().padStart(4," ")}`)).join("")}`,n=e.findIndex((t=>t.startsWith("M")&&t.includes("END")));e.splice(n,0,t)}return s.filter((t=>!!Number.parseInt(t))).map((t=>Number.parseInt(t)+i)).forEach((t=>{const n=e[t].split(" "),i=n.findIndex((t=>"R#"===t));if(-1!==i){for(let t=i+1;t<n.length;t++)n[t]&&1==n[t].length&&(Number.parseInt(n[t])??0)>0&&(n[t]="0");e[t]=n.join(" ")}})),e.join("\n")}function kn(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=In(t,"capGroupName");n=n.replace(`[*:${e}]`,`[${i}]`)})),n}async function On(t){let e;try{e=JSON.parse(t.get(An.META)??"{}");for(const t in e)"object"==typeof e[t]&&(e[t]=JSON.stringify(e[t])),("string"!=typeof e[t]||e[t]!==a.INT_NULL.toString()&&e[t]!==a.FLOAT_NULL.toString())&&("number"!=typeof e[t]||e[t]!==a.INT_NULL&&e[t]!==a.FLOAT_NULL)||(e[t]=null)}catch(t){console.error(t)}const n=t.get(An.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=r.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=Rn(i)}catch(t){r.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(t)}let o=t.get(An.NATURAL_ANALOG);const s=t.get(An.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(t.get(An.R_GROUPS)??"[]"),!o&&s){const t=await Cn(kn(n,l),s);t&&(o=t)}}catch(t){l??=[]}return{symbol:t.get(An.SYMBOL),name:t.get(An.NAME),molfile:i,smiles:n,polymerType:s,monomerType:t.get(An.MONOMER_TYPE),naturalAnalog:o,id:t.get(An.ID),rgroups:l,meta:e,author:t.get(An.AUTHOR),createDate:t.get(An.CREATE_DATE)}}class Hn{_colors;_colorInputs;constructor(t){this._colors=t,this._colorInputs={line:s.input.color("Line",{value:t.line,onValueChanged:t=>this._colors.line=t}),background:s.input.color("Background",{value:t.background,onValueChanged:t=>this._colors.background=t}),text:s.input.color("Text",{value:t.text,onValueChanged:t=>this._colors.text=t})}}get colors(){return this._colors}set colors(t){const e={line:a.Color.toHtml(a.Color.fromHtml(t.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(t.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(t.text??"#000000"))};this._colors=e;for(const t in this._colorInputs)this._colorInputs[t].value=e[t]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(t){this._selected=t,this.root.style.border=t?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(t){this.monomer=t}render(){s.empty(this.root);const t=this.monomer.smiles&&r.chem.checkSmiles(this.monomer.smiles)?r.chem.drawMolecule(this.monomer.smiles,200,200):r.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(t);const e=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(e),s.tooltip.bind(e,this.monomer.name),this.monomer.lib?.source){const t=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(t),s.tooltip.bind(t,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(t,e,n,i){this.monomerSymbol=t,this.monomers=e,this.monomerCards=e.map((t=>new Gn(t)));const o=s.divH([],{style:{overflowX:"auto",width:"100%"}}),r=s.h1(t,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(r,t),this.root.appendChild(r),this.root.appendChild(o),this.monomerCards.forEach((t=>{t.root.onclick=()=>{this.monomerCards.forEach((t=>t.selected=!1)),t.selected=!0,i(t.monomer)},n&&t.monomer===n&&(t.selected=!0),o.appendChild(t.root)}))}render(){this.monomerCards.forEach((t=>t.render()))}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await dn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Dn._instance.refresh()))),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Nt.ub)();const t=await dn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.monomers=t.duplicateMonomers,this.monomerCardRows=[];for(const e in this.monomers)for(const n in this.monomers[e]){const i=this.settings.duplicateMonomerPreferences?.[e]?.[n]??null,o=i?this.monomers[e][n].find((t=>t.lib?.source===i))??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[e][n],o,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][n]=i.lib.source,await(0,Nt.Eu)(this.settings),r.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),t.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(t=>(this.monomerCardRows[t].render(),this.monomerCardRows[t].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>t(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const t=t=>{this.filteredMonomerRows=this.monomerCardRows.filter((e=>e.monomerSymbol.toLowerCase().includes(t.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)))}}}constructor(){}get root(){return this._root}}async function Bn(){await jn.showDialog()}async function Vn(t=!0){return await qn.showView(t)}class Wn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Wn.instancePromise&&(Wn.instancePromise=(async()=>{const t=new Wn,e=await(0,bt.pj)();return t._fileManager=await e.getFileManager(),t._widget=await t.createWidget(),t})()),Wn.instancePromise}static async reloadWidget(){const t=await Wn.getInstance();t._widget=await t.createWidget()}async createWidget(){const t=await this.getWidgetContent();return(await(0,bt.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(t)}async getWidgetContent(){const t=await Un.createControlsForm();return mn()(t).addClass("monomer-lib-controls-form"),setTimeout((()=>{t&&mn()(t)&&mn()(t).removeClass("ui-form-condensed")}),200),s.divV([t])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async t=>{const e=await t.text(),n=t.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(e,n)}catch(t){r.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Un{fileManager;userLibSettings;constructor(t,e){this.fileManager=t,this.userLibSettings=e,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([t,e])=>{this.updateLibrarySelectionStatus(e,t)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){io.logger.debug("LibraryControlsForm.createControlsForm(), start");const[t,e]=await Promise.all([(0,bt.pj)().then((t=>t.getFileManager())),await(0,Nt.ub)()]);return new Un(t,e)._createControlsForm()}_createControlsForm(){const t=this.createLibraryControls(),e=s.wideForm(t,void 0);return mn()(e).addClass("monomer-lib-controls-form"),e}updateControlsForm(){const t=this._createControlsForm();mn()(".monomer-lib-controls-form").replaceWith(t)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((t=>this.createLibInput(t)))}createLibInput(t){const e=`${this.toLog()}.createLibInput()`;io.logger.debug(`${e}, libFileName = '${t}', start`);const n=!this.userLibSettings.exclude.includes(t),i=s.input.bool(t,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(t,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${t}`);const o=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(t))),a=s.icons.edit((async()=>{r.shell.v=await(await Tn.getInstance()).getViewRoot(t)}),"Edit monomer library");return s.tooltip.bind(o,`Delete ${t}`),i.addOptions(a),i.addOptions(o),io.logger.debug(`${e}, libFileName = '${t}', end`),i}async updateLibrarySelectionStatus(t,e){this.updateLibrarySettings(t,e),await(0,Nt.Eu)(this.userLibSettings);const n=await(0,bt.pj)();await n.loadMonomerLib(!0),r.shell.info("Monomer library user settings saved")}updateLibrarySettings(t,e){t?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((t=>t!==e)):this.userLibSettings.exclude.includes(e)||this.userLibSettings.exclude.push(e)}promptForLibraryDeletion(t){s.dialog("Warning").add(s.divText(`Delete file ${t}?`)).onOK((async()=>{try{const e=a.TaskBarProgressIndicator.create(`Deleting ${t} library`);await this.updateLibrarySelectionStatus(!1,t),await this.fileManager.deleteLibraryFile(t),e.close()}catch(e){console.error(e),r.shell.error(`Failed to delete ${t} library`)}})).showModal(!1)}}class jn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){jn._instance||(jn._instance=new jn,jn._instance.closeDialogSubject$.subscribe((()=>{jn._instance.dialog=void 0}))),jn._instance.dialog||(jn._instance.dialog=await jn._instance.getDialog()),jn._instance.dialog.show()}async getDialog(){const t=un.getInstance(),e=(await Wn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});mn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>t.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class qn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(t=!0){const e=un.getInstance(),n=(await Wn.getInstance()).widget,i=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),o=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,o])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);if(this._view)try{this._view.subs.forEach((t=>t.unsubscribe())),this._view.detach(),this._view.close()}catch(t){}return this._view=a.View.fromRoot(l),this._view.name=qn.viewName,t&&r.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const t=Array.from(l.children).filter((t=>t.classList.contains("ui-box")));if(2!==t.length)return;const[e,n]=t,i=e.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;e.style.width=`${o}px`;const r=i-o;n.style.width=`${r}px`}),100),this._view.subs.push(r.events.onCurrentViewChanged.subscribe((()=>{try{const t=qn._instance;t&&t._view&&r.shell.v&&"id"in r.shell.v&&r.shell.v.id===t._view.id&&t._duplicateManager?.refresh()}catch(t){console.error(t)}})))})),this._view}static async showView(t=!0){return qn._instance||(qn._instance=new qn),qn._instance._duplicateManager||(qn._instance._duplicateManager=await Dn.getInstance()),qn._instance.libManager||(qn._instance.libManager=await dn.getInstance()),t&&qn._instance._view&&Array.from(r.shell.views).find((t=>t.id&&t.id===qn._instance._view.id))?(r.shell.v=qn._instance._view,await qn._instance._duplicateManager.refresh(),qn._instance._view):(qn.closeExistingViews(),qn._instance.getView(t))}static closeExistingViews(){Array.from(r.shell.views).filter((t=>t.name===qn.viewName)).forEach((t=>t.close()))}async mergeSelectedLibs(){const t="Library with this name already exists",e=await dn.getInstance();if(await e.awaitLoaded(),await e.loadLibrariesPromise,!e.duplicatesHandled)return void r.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=e.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),o=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const e=h(o.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!e&&e!==t),i.getButton("Save")?.classList?.toggle("d4-disabled",!!e)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let t=o.value;return t.endsWith(".json")||(t+=".json"),t}function h(e){return e&&e.trim()?e.endsWith(".json")&&l.includes(e)||l.includes(e+".json")?t:null:"Library name cannot be empty"}o.addValidator(h),i.add(o).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const t=c(),e=JSON.stringify(n),o=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await o.addLibraryFile(e,t,!1);const n=await(0,Nt.ub)();n.exclude=l,await(0,Nt.Eu)(n),await this.libManager.loadLibraries(!0),await Wn.reloadWidget()}catch(e){r.shell.error(`Failed to save library ${t}. see console for details.`),console.error(e)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var zn,Yn=function(t,e,n,i){return new(n||(n=Promise))((function(o,r){function s(t){try{l(i.next(t))}catch(t){r(t)}}function a(t){try{l(i.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?o(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};class Kn{_setBreadcrumbsInViewName(){var t,e;const n=["Home","Demo",...(null!==(t=this._path)&&void 0!==t?t:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((t=>Yn(this,void 0,void 0,(function*(){const e=t[t.length-1];if(e===i.path[i.path.length-1])return;const n=r.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===e?n:n.items.find((t=>t.text===e))})))),r.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const t=s.iconFA("home",(()=>{r.shell.v.close(),r.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));t.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(t)}const t=null===(e=r.shell.v.ribbonMenu.root.parentElement)||void 0===e?void 0:e.getElementsByClassName("d4-ribbon-name")[0];t&&(t.textContent="",t.appendChild(i.root))}}constructor(t,e,n=!1,i){var o,r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Yn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Yn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._path=null!==(r=null==i?void 0:i.path)&&void 0!==r?r:"",this._progress.max=0,this._progress.value=1,Kn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=s.divH([n,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){r.shell.windows.showContextPanel=!0,r.shell.windows.showHelp=!1,this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var t;r.shell.v&&(r.shell.v.name=this.name,r.shell.v.path=`${this.DEMO_PATH}/${(null!==(t=this._path)&&void 0!==t?t:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Yn(this,void 0,void 0,(function*(){var t,e;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const l=n,c=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(t){console.error(t)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,te.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}r.shell.v instanceof a.TableView&&(yield r.data.detectSemanticTypes(r.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Yn(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Yn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let o=n/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){return Yn(this,void 0,void 0,(function*(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Yn(this,void 0,void 0,(function*(){r.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){r.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Kn.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Yn(this,void 0,void 0,(function*(){this._initRoot(),r.shell.v.name===this.name&&(r.shell.v.close(),this._node=r.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r.shell.dockManager.findNode(r.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Kn.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(zn||(zn={}));var Zn=n(966),Xn=n(608),Jn=n(1619);class Qn{urlParams;funcName;options;df;view;constructor(t,e,n={}){this.urlParams=t,this.funcName=e,this.options=n}async init(t){this.df=t,await this.buildView()}async buildView(){const t=$()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=r.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${io.name}.${this.funcName}?${t}`;const e={...this.options,sequenceColumnName:"sequence"};for(const[t,n]of this.urlParams.entries())switch(t){case oe.n5.fixWidth:case oe.n5.fitArea:e[t]=["1","on","true"].includes(n.toLowerCase());break;default:e[t]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ti{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:r.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const t=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:t,filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ei=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};const ni="-";class ii extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,o,r,s){t.save(),t.beginPath(),t.rect(e,n,i,o),t.clip();try{if(!r.isTableCell)return;const s=r.cell?.column&&r.cell.column?.dart&&"true"===r.cell.column.getTag(Rt.Mn.applyToBackground);t.font="12px monospace",t.textBaseline="middle",t.textAlign="left";let a=r.cell.value;a&&a!==wt._S||(a=ni);const l=a.split(wt.ot).map((t=>t&&t!==wt._S?t.trim():ni)),c=l.map((t=>(0,gt.zS)(t,Math.max(2,Math.floor(.15*i/l.length))))),h=c.map((e=>t.measureText(e).width)),u=h.reduce(((t,e)=>t+e),0);let d=e+(i-u)/2;const p=this.tableCol.getTag(wt.gp.alphabet),m=p===gt.YI.RNA||p===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA;for(let r=0;r<c.length;r++){const a=l[r];let u=kt.S$,p="rgb(255, 255, 255)";if(this.monomerLib)if(s){const t=this.monomerLib.getMonomerColors(m,a);u=t?.textcolor??u,p=t?.backgroundcolor??p}else u=this.monomerLib.getMonomerTextColor(m,a);s&&1==l.length&&(t.fillStyle=p,t.fillRect(e,n,i,o)),t.fillStyle=u,t.fillText(c[r],d,n+o/2,i),d+=h[r]}}finally{t.restore()}}onMouseMove(t,e){if(t.grid.dart!=this.gridCol?.grid.dart||t.gridColumn.dart!=this.gridCol?.dart||!t.tableColumn||!t.isTableCell)return!1;const n=t.tableColumn.getTag(wt.gp.alphabet),i=t.cell.value,o=t.grid.canvas.getBoundingClientRect(),r=t.bounds.right+o.left-4,a=t.bounds.bottom+o.top-4;if(!i||i==wt._S||i==ni)return s.tooltip.show(s.divText("gap"),r,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),r,a),!0;const l=n===gt.YI.RNA||n===gt.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA,c=i.split(wt.ot).map((t=>t&&t!==wt._S&&t!==ni?this.monomerLib.getTooltip(l,t):s.divText("gap"))),h=s.divH(c,{style:{alignItems:"top"}}),u=Array.from(h.querySelectorAll("canvas"));if(u.length>2){const t=Math.floor(550/u.length);u.forEach((e=>{e.style.setProperty("max-width",`${t}px`,"important"),e.style.setProperty("max-height",`${t}px`,"important")}))}return s.tooltip.show(h,r,a),!0}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Gt.BG)(t);let o=i.rendererBack;return o||(o=i.rendererBack=new ii(e,n)),o}}class oi extends a.GridCellRenderer{get name(){return Wt.uF.MONOMER}get cellType(){return Wt.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,n,i,o,r,s){ii.getOrCreate(r).render(t,e,n,i,o,r,s)}onMouseMove(t,e){ii.getOrCreate(t).onMouseMove(t,e)}}class ri{constructor(t,e,n=""){this.target=t,this.debugEnabled=e,this.prefix=n}error(t,e,n){return this.target.error(this.prefix+t,e,n)}warning(t,e){return this.target.warning(this.prefix+t,e)}info(t,e){return this.target.info(this.prefix+t,e)}debug(t,e){if(this.debugEnabled)return this.target.debug(this.prefix+t,e)}}class si extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const t=super.get("FontSize");return t&&!isNaN(t)?Number.parseInt(t):12}set fontSize(t){super.set("FontSize",t),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const t=super.get("MaxMonomerLength");return"long"===t?null:parseInt(t)}set maxMonomerLength(t){const e=null===t?"long":t.toString();super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(t){this._properties=t}_initialized=!1;get initialized(){return this._initialized}constructor(t={debug:!1}){super(),super._logger=new ri(super.logger,t.debug)}completeInit(t,e,n,i){this._seqHelper=t,this._monomerLib=e,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(t){const[e,n]=(0,Ct.AP)(t);r.shell.error(e),this.logger.error(e,void 0,n)}}var li=n(5999),ci={};ci.styleTagTransform=A(),ci.setAttributes=b(),ci.insert=g().bind(null,"head"),ci.domAPI=m(),ci.insertStyleElement=w(),d()(li.A,ci),li.A&&li.A.locals&&li.A.locals;var hi=n(6307);class ui extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(t,e){super(s.divV([])),this.seqCol=t,this.seqHelper=e}async init(){const t=this.seqHelper.getSeqHandler(this.seqCol),e=io.properties.tooltipWebLogo,n=this.seqCol.getTag(ee.gp.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function di(t,e,n,i){const o=io.seqHelper.getSeqHandler(t);let r=null,s=null;for(let t=0;t<o.posList.length;++t)o.posList[t]==e&&(r=t),o.posList[t]==n&&(s=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(o.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${n??""})`;return o.getRegion(r,s,a)}const pi={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(gt.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class mi{urlParams;funcName;view;data;constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??pi;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(gt.gp.positionNames,this.data.positionNames),this.data.regions&&e.setTag(gt.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await r.data.detectSemanticTypes(this.data.df),this.view=r.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${io.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class fi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(t,e){this.call=t,this.seqHelper=e;const n=t=>this.call.inputParams[t].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??r.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:r.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const t in this.call.inputParams)s.tooltip.bind(this.inputs[t].captionLabel,n(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&this.seqHelper.getSeqHandler(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?this.seqHelper.getSeqHandler(t):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),o=document.createElement("option");e.text=o.text=t,e.value=o.value=t,n.options.add(e),i.options.add(o)}n.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(gt.gp.regions):null,n=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const o=document.createElement("option");if(o.text="",o.value=JSON.stringify(null),i.options.add(o),null!=n){this.inputs.region.root.style.removeProperty("display");for(const t of n){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const o=t.options[i],r=JSON.parse(o.value);r&&e===r.start&&n===r.end&&(t.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",o=this.inputs.end.stringValue??"";return null!=e?`${n.name}(${e.name}): ${e.start}-${e.end}`:`${n?.name}: (${i}-${o})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(t).onOK((()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{io.handleErrorUI(t)}))})).show()}widget(){const t=s.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=s.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{io.handleErrorUI(t)}))}));return a.Widget.fromRoot(s.divV([t,s.div(e)]))}}var gi=n(8754);async function yi(t,e,n,i,o){const r=await async function(t,e,n,i,o){const r=(0,vt.R)(e,o),s=o.getSeqHandler(e).getNewColumnFromList("ref",[n]),l=o.getSeqHandler(s).getSplitted(0),c=i===ft.IDENTITY?function(t,e){const n=e.columns.length,i=new Array(n),o=new Array(n),r=new Array(n);for(let s=0;s<n;++s){const n=e.columns.byIndex(s);i[s]=n.getRawData(),o[s]=n.categories.indexOf("");const a=s<t.length?t.getOriginal(s):wt._S;r[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",e.rowCount),l=s.getRawData();for(let n=0;n<e.rowCount;++n){l[n]=0;for(let e=0;e<t.length;++e)(i[e]?i[e][n]:0)===r[e]&&++l[n];l[n]/=t.length}return s}(l,r):i===ft.SIMILARITY?await async function(t,e,n){const i=e.columns.toList();return await(0,bt.uL)(i,t,n)}(l,r,o):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=t.columns.getUnusedName(c.name),t.columns.add(c),c}(t,e,n,i,o);for(let t=0;t<r.length;t++)e.isNone(t)&&r.set(t,null,!1);return r}var bi=n(294),vi=n(330);const wi=OCL;var Ci=n(9099);class Ai{monomerSymbol;constructor(t){this.monomerSymbol=t}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const t=this.rGroups.getAtomicIdx(1);if(null===t)return;const{x:e,y:n}=this.atoms.atomCoordinates[t];this.atoms.shift({x:-e,y:-n})}alignR2AlongX(){const t=this.rGroups.getAtomicIdx(2);if(null===t)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const e=this.atoms.atomCoordinates[t],n=e.y/e.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(t){this.rGroups.deleteBondLineWithSpecifiedRGroup(t)}shiftCoordinates(t){this.atoms.shift(t)}rotateCoordinates(t){this.atoms.rotate(t)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(t){this.rGroups.removeRGroups(t)}replaceRGroupWithAttachmentAtom(t,e){this.rGroups.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.rGroups.getAttachmentAtomIdByRGroupId(t)}shiftBonds(t){this.bonds.shift(t)}capRGroups(t){this.rGroups.capRGroups(t)}}var Si=n(6956);class xi{atoms;bonds;constructor(t,e,n){this.atoms=e,this.bonds=n,this.rGroupIdToAtomicIndexMap=t.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(t){const e=this.rGroupIdToAtomicIndexMap.get(t);return void 0===e?null:e}removeRGroupsFromAtomBlock(t){t.forEach((t=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(t))throw new Error(`Cannot find atomic index for R group ${t}`)}));const e=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([e,n])=>t.includes(e))).map((([t,e])=>e));this.atoms.deleteAtoms(e)}removeRGroups(t){this.removeRGroupsFromAtomBlock(t),t.forEach((t=>{const e=this.replaceRGroupInBondsByDummy(t);this.rGroupBondPositionMap.set(t,e)}))}replaceRGroupInBondsByDummy(t){const e=this.rGroupIdToAtomicIndexMap.get(t);if(this.rGroupBondPositionMap.has(t))throw new Error(`R group ${t} is already handled`);const n=this.bonds.getPositionsInBonds(e+1);if(0===n.length)throw new Error(`Cannot find position for R group ${t}`);if(n.length>1)throw new Error(`More than one position for R group ${t}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(e+1),this.removeRGroupFromAtomicIdxMap(t,e),i}removeRGroupFromAtomicIdxMap(t,e){this.rGroupIdToAtomicIndexMap.delete(t);for(const[t,n]of this.rGroupIdToAtomicIndexMap)n>e&&this.rGroupIdToAtomicIndexMap.set(t,n-1)}deleteBondLineWithSpecifiedRGroup(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n}=e;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(t),this.rGroupIdToAtomicIndexMap.delete(t),this.rGroupBondPositionMap.forEach((t=>{t.bondLineIdx>n&&(t.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(t,e){const n=this.rGroupBondPositionMap.get(t);if(!n)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:i,nodeIdx:o}=n;this.bonds.bondedAtoms[i][o]=e}getAttachmentAtomIdByRGroupId(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n,nodeIdx:i}=e;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(t){this.rGroupIdToAtomicIndexMap.forEach(((e,n)=>{const i=t[n-1];i===Si.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(e,i)}))}}class Ei{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(t,e){this.rawAtomLines[t]=this.rawAtomLines[t].replace("R#",e)}deleteAtoms(t){this.coordinates=this.coordinates.filter(((e,n)=>!t.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((e,n)=>!t.includes(n)))}shift(t){this.coordinates=this.coordinates.map((e=>{const n=e.x+t.x,i=e.y+t.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${t.x}, ${t.y}`);return{x:n,y:i}}))}rotate(t){this.coordinates=this.coordinates.map((e=>{const n=e.x,i=e.y,o=n*Math.cos(t)-i*Math.sin(t),r=n*Math.sin(t)+i*Math.cos(t);if(isNaN(o)||isNaN(r))throw new Error(`Cannot rotate coordinates by ${t}`);return{x:o,y:r}}))}}class Ti extends Ei{constructor(t){super(),this.rawAtomLines=t.getAtomLines(),this.coordinates=this.rawAtomLines.map((t=>({x:parseFloat(t.substring(0,10)),y:parseFloat(t.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((t,e)=>{const n=this.coordinates[e];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${t.substring(20)}`}))}}class Mi{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(t){this.rawBondLines=this.rawBondLines.filter(((e,n)=>!t.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((e,n)=>!t.includes(n)))}getPositionsInBonds(t){const e=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,o)=>{n===t&&e.push({bondLineIdx:i,nodeIdx:o})}))})),e}replacePositionsInBondsByDummy(t,e){void 0===e&&(e=-1),t.forEach((t=>{const{bondLineIdx:n,nodeIdx:i}=t;this.bondedAtomPairs[n][i]=e}))}removeAtomIdFromBonds(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e>t?e-1:e))))}shift(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e+t))))}}class _i extends Mi{constructor(t){super(),this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((t=>[parseInt(t.substring(0,3)),parseInt(t.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((t,e)=>{if(t.some((t=>-1===t)))throw new Error(`Bonded pair ${t} contains -1`);return`${t[0].toString().padStart(3," ")}${t[1].toString().padStart(3," ")}${this.rawBondLines[e].substring(6)}`}))}}class Ii extends Ai{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Ti(n),this.bonds=new _i(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Li extends Ei{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawAtomLines=t.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const t=this.molfileHandler.x,e=this.molfileHandler.y;return Array.from(t).map(((t,n)=>({x:t,y:e[n]})))}get atomLines(){const t=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,e=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const o=this.coordinates[i],r=o.x.toFixed(4)+"00",s=o.y.toFixed(4)+"00";return n.replace(t,((t,e,n,i,o,a)=>e+r+i+s+a)).replace(e,"")}))}replaceRGroupSymbolByElement(t,e){super.replaceRGroupSymbolByElement(t,e);const n=this.rawAtomLines[t].substring(3).split(" ");n.length>7&&(this.rawAtomLines[t]=`M  ${n.slice(0,7).join(" ")}`)}}class Ni extends Mi{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((t=>[t[0],t[1]]))}getBondLines(){const t=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((e,n)=>{if(e.some((t=>-1===t)))throw new Error(`Bonded pair ${e} contains -1`);return this.rawBondLines[n].replace(t,((t,n,i,o,r,s)=>`${n}${e[0]}${o}${e[1]}${s}`))}))}}class Pi extends Ai{constructor(t,e){super(e);const n=$e.getInstance(t);this.atoms=new Li(n),this.bonds=new Ni(n),this.rGroups=new xi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class $i{static getInstance(t,e){if($e.isMolfileV2K(t))return new Ii(t,e);if($e.isMolfileV3K(t))return new Pi(t,e);throw new Error("Unsupported molfile version")}}class Ri{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(t,e,n,i,o,r){this.monomerSymbol=t,this.monomerIdx=e,this.helm=n,this.monomerLib=r;const s=this.getLibraryMonomerObject();let a=s.molfile;$e.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,t,o)),this.molfileWrapper=$i.getInstance(a,t),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[e]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(t,e,n){if(Ri.molfileV2KToV3KCache.has(t))return Ri.molfileV2KToV3KCache.get(t);let i=null;try{if(i=n.get_mol(t,JSON.stringify({mergeQueryHs:!0})),i){const e=i.get_v3Kmolblock();return Ri.molfileV2KToV3KCache.set(t,e),e}throw new Error(`Cannot convert ${e} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const t=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),e=this.monomerLib.getMonomer(t,this.monomerSymbol);if(!e)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return e}getCapGroupElements(t){return t.rgroups.map((t=>(t.capGroupSmiles||t.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(t){this.molfileWrapper.shiftCoordinates(t)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(t){this.molfileWrapper.removeRGroups(t)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(t,e){this.molfileWrapper.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.molfileWrapper.getAttachmentAtomByRGroupId(t)}deleteBondLineWithSpecifiedRGroup(t){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(t)}shiftBonds(t){this.molfileWrapper.shiftBonds(t)}}class ki{rdKitModule;monomerLib;constructor(t,e,n){this.rdKitModule=e,this.monomerLib=n,this.helm=new Ci.f(t)}monomerWrappers=[];helm;addMonomer(t,e,n){if(t===wt.b9[gt.Hi.HELM])return;const i=this.monomerWrappers.length,o=new Ri(t,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(o)}getAtomNumberShifts(){const t=[];let e=0;return this.monomerWrappers.forEach((n=>{t.push(e),e+=n.getAtomLines().length})),t}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((t=>{const e=t.map((t=>t.monomerIdx)),n=t.map((t=>t.rGroupId)),i=e.map((t=>this.monomerWrappers[t])),o=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],o),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const t=[],e=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((t,e)=>{t.shiftBonds(n[e])})),this.restoreBondsBetweenMonomers();const i=new bi.Cg;for(const[n,o]of $().enumerate(this.monomerWrappers)){const r=t.length,s=e.length;t.push(...n.getAtomLines()),e.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(o)?Ft.o.NUCLEOTIDE:Ft.o.AA;i.set(o,{biotype:a,symbol:n.monomerSymbol,atoms:$().count(r).take(n.atomCount).toArray(),bonds:$().count(s).take(n.bondCount).toArray()})}const o=t.length,r=e.length;return{molfile:[this.getV3KHeader(o,r),this.getV3KAtomBlock(t),this.getV3KBondBlock(e),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(t,e){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${t} ${e} 0 0 1`}getV3KAtomBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,o)=>e+i+o))})),"M  V30 END BOND"].join("\n")}}class Oi{constructor(t){this.molfileHandler=$e.getInstance(t)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(t){return{x:this.molfileHandler.x[t],y:this.molfileHandler.y[t]}}}class Hi{helmHelper;rdKitModule;monomerLib;constructor(t,e,n){this.helmHelper=t,this.rdKitModule=e,this.monomerLib=n}convertToSmiles(t){const e=t.dataFrame,n=this.getSmilesList(t),i=`smiles(${t.name})`,o=e?e.columns.getUnusedName(i):i;return a.Column.fromStrings(o,n.map((t=>null===t?"":t)))}getSmilesList(t){return this.convertToMolfileV3KColumn(t).toList().map((t=>a.chem.convert(t,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(t){try{if(!t)return"";return wi.Molecule.fromMolfile(t).toMolfileV3().replace("STERAC1","STEABS")}catch(t){const[e,n]=(0,Ct.AP)(t);return io.logger.error(e,void 0,n),""}}getMolV3000ViaOCL(t,e){const n=t.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})),i=new Array(n.length),o=a.TaskBarProgressIndicator.create("Handling chirality...");for(let t=0;t<n.length;t++){i[t]=this.molV3KtoMolV3KOCL(n[t]);const e=t/n.length*100;o.update(e,`${e?.toFixed(2)}% of molecules completed`)}return o.close(),a.Column.fromStrings(e,i)}convertToRdKitBeautifiedMolfileColumn(t,e,n,i){const o=t.dataFrame,r=this.convertToMolfileV3KColumn(t).toList().map((t=>{if(""===t)return null;const e=n.get_mol(t);return e?(e.set_new_coords(),e.normalize_depiction(1),e.straighten_depiction(!0),e):null})),s=`molfile(${t.name})`,l=o?o.columns.getUnusedName(s):s;return e?this.getMolV3000ViaOCL(r,l):a.Column.fromStrings(l,r.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})))}convertToMolfileV3KColumn(t){const e=t.dataFrame,n=this.convertToMolfileV3K(t.toList()).map((t=>t.molfile)),i=(0,vi.kA)(e,`molfileV3K(${t.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(t){const e=new Array(t.length);for(let n=0;n<t.length;++n){const i=t[n];if(!i){e[n]=bi.vF.createEmpty();continue}let o;try{o=this.getPolymerMolfile(i)}catch(t){const[e,n]=(0,Ct.AP)(t);io.logger.error(e,void 0,n),o=bi.vF.createEmpty()}e[n]=o}return e}getPolymerGraphColumn(t){const e=t.toList(),n=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",n)}getPolymerMolfile(t){const e=this.helmHelper.removeGaps(t),n=e.resHelm,i=new Map;for(const[t,n]of e.monomerMap?.entries()??[])i.set(n,t);const o=this.helmHelper.getMolfiles([n])[0],r=new Oi(o),s=new ki(n,this.rdKitModule,this.monomerLib);r.monomerSymbols.forEach(((t,e)=>{const n=r.getMonomerShifts(e);s.addMonomer(t,e,n)}));const a=s.compileToMolfile(),l=new bi.Cg;for(const[t,e]of a.monomers.entries()){const n=i.get(t);l.set(n,e)}return new bi.vF(a.molfile,l)}}class Gi{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(t,e){if(this.seqHelper=e,t.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${a.TYPE.STRING}'.`);this._column=t;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ut.notationProvider]??null);const i=this.isFasta()?wt.b9[gt.Hi.FASTA]:this.isSeparator()?wt.b9[gt.Hi.SEPARATOR]:this.isHelm()?wt.b9[gt.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??wt.b9[gt.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(gt.gp.aligned)||!this.column.tags.has(gt.gp.alphabet)||!this.column.tags.has(gt.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===gt.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag(gt.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,e)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(gt.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(gt.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${gt.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||t.temp.seqHandlerRefined||(this.refineSeparatorNotation(),t.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const t=((t,e,n)=>{const i={};let o=!0,r=null;for(const e of t){const t=e?n(e):[];if(null===r?r=t.length:t.length!==r&&(o=!1),t.length>=3)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:o}})([...new Set((this.column.length<100?$().count(0).take(Math.min(100,this.column.length)).map((t=>this.column.get(t))):this.column.categories.slice(0,100)).map((t=>t?t.substring(0,500):"")).filter((t=>0!==t.length)))],0,(t=>t.split(this.separator)));let e=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const o=n[0].prepare({col:this.column,stats:t,separator:this.separator}),r=(await o.call()).getOutputParamValue();e||=r}catch(t){console.error(t)}e&&(delete this.column.temp[Ut.seqHandler],this.column.fireValuesChanged())}static setTags(t){const e=t.column.meta.units;if([gt.Hi.FASTA,gt.Hi.SEPARATOR].includes(e)){if(!t.column.getTag(gt.gp.alphabet)&&0===Object.keys(t.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let e=t.column.getTag(gt.gp.aligned);null===e&&(e=t.stats.sameLength?"SEQ.MSA":"SEQ",t.column.setTag(gt.gp.aligned,e));let n=t.column.getTag(gt.gp.alphabet);if(null===n&&(n=(0,Ot.pc)(t.stats.freq,gt.q7),t.column.setTag(gt.gp.alphabet,n)),n===gt.YI.UN){const e=Object.keys(t.stats.freq).length,n=Object.keys(t.stats.freq).some((t=>t.length>1));t.column.setTag(gt.gp.alphabetSize,e.toString()),t.column.setTag(gt.gp.alphabetIsMultichar,n?"true":"false")}}else if(e===gt.Hi.HELM){let e=t.column.getTag(gt.gp.alphabet);null===e&&(e=(0,Ot.p0)(t.stats.freq,gt.q7,t.defaultGapOriginal),t.column.setTag(gt.gp.alphabet,e))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const t=this.column.getTag(gt.gp.separator)??void 0;if(this.notation===gt.Hi.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag(gt.gp.aligned);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag(gt.gp.alphabet);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get defaultBiotype(){return this.alphabet===gt.YI.RNA||this.alphabet===gt.YI.DNA?Ft.o.NUCLEOTIDE:Ft.o.AA}get helmCompatible(){return this.column.getTag(gt.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==gt.Hi.HELM||this.alphabet==gt.YI.UN){const t=this.column.getTag(gt.gp.alphabetSize);let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case gt.YI.PT:return 20;case gt.YI.DNA:case gt.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===gt.Hi.HELM||this.alphabet===gt.YI.UN&&"true"===this.column.getTag(gt.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(t,e){if(this.cached&&void 0===e){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let e=this._splitted[t]?this._splitted[t].deref():void 0;if(!e){const n=this.column.get(t);e=this.splitter(n),this._splitted[t]=new WeakRef(e)}return e}{const n=this.column.get(t);return this.getSplitter(e)(n)}}getMonomerAtPosition(t,e,n){if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const i=(this.column.get(t)??"")[e];return n?i===wt.b9[gt.Hi.FASTA]?wt._S:i??wt._S:i??""}const i=this.getSplitted(t);return e<0||e>=i.length?this.defaultGapOriginal:n?i.getCanonical(e):i.getOriginal(e)}getMonomersAtPosition(t,e){const n=this.column.length,i=new Array(n).fill(wt._S);if(this.isCanonicalAlphabet&&this.isFasta()&&!this.getAlphabetIsMultichar()){const o=this.column.categories,r=this.column.getRawData();for(let s=0;s<n;s++){const n=o[r[s]]??"";if(t<n.length){const o=n[t];i[s]=e?o===wt.b9[gt.Hi.FASTA]?wt._S:o??wt._S:o??""}}}else for(let o=0;o<n;o++){const n=this.getSplitted(o);t>=0&&t<n.length&&(i[o]=e?n.getCanonical(t):n.getOriginal(t))}return i}getValue(t,e){return this.column.get(t),new jt(t,this)}getHelm(t){let e;const n=this.column.get(t);return e=this.notation===gt.Hi.HELM?n:this.notation===gt.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(gt.Hi.HELM)(n),e}_stats=null;get isCanonicalAlphabet(){const t=this.alphabet;return t===gt.YI.DNA||t===gt.YI.RNA||t===gt.YI.PT}get stats(){if(null===this._stats){const t={};let e=!0,n=null;const i=this.column.length;for(let o=0;o<i;++o){const i=this.getSplitted(o);null==n?n=i.length:i.length!==n&&(e=!1);for(let e=0;e<i.length;++e){const n=i.getCanonical(e);n in t||(t[n]=0),t[n]+=1}}this._stats={freq:t,sameLength:e}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:$().count(0).take(this.column.length).map((t=>this.getSplitted(t).length)).reduce(((t,e)=>t>e?t:e),0)),this._maxLength}_posList=null;get posList(){if(null===this._posList){const t=this.column.getTag(gt.gp.positionNames);this._posList=t?t.split(gt.z1).map((t=>t.trim())):$().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===gt.Hi.FASTA}isSeparator(){return this.notation===gt.Hi.SEPARATOR||!!this.separator}isFastaOrSeparator(){return this.isFasta()||this.isSeparator()}isHelm(){return this.notation===gt.Hi.HELM}isCustom(){return this.notation===gt.Hi.CUSTOM}isRna(){return this.alphabet===gt.YI.RNA}isDna(){return this.alphabet===gt.YI.DNA}isPeptide(){return this.alphabet===gt.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||t===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return gt.Hi.FASTA;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return gt.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.Hi.HELM;if(this.units.toLowerCase().startsWith(gt.Hi.CUSTOM))return gt.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e,n,i){const o=this.column,r=t.toLowerCase()+"("+o.name+")",s=n??o.dataFrame?.columns.getUnusedName(r)??r,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=t,t===gt.Hi.SEPARATOR){if(!e)throw new Error(`Notation '${gt.Hi.SEPARATOR}' requires separator value.`);l.setTag(gt.gp.separator,e)}l.setTag(a.TAGS.CELL_RENDERER,t===gt.Hi.HELM?"helm":"sequence");const c=o.getTag(gt.gp.aligned);c&&l.setTag(gt.gp.aligned,c);let h=o.getTag(gt.gp.alphabet);h||this.notation!==gt.Hi.HELM||t===gt.Hi.HELM||(h=gt.YI.UN),null!=h&&l.setTag(gt.gp.alphabet,h);let u=o.getTag(gt.gp.alphabetSize);null!=h&&u&&l.setTag(gt.gp.alphabetSize,u);const d=o.getTag(gt.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(gt.gp.alphabetIsMultichar,d),t==gt.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(gt.gp.alphabetSize,u)),l}getNewColumnFromList(t,e){return this.getNewColumn(this.notation,this.separator,t,e)}static unitsStringIsValid(t){return t=t.toLowerCase(),[gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!Gi.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",e,new Array(t).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(t){let e=null;if(e=this.notationProvider?this.notationProvider.splitter:null,e)return e;if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return null===this.column.getTag(gt.gp.alphabet)||this.getAlphabetIsMultichar()?gt.J9:Ot.tm;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return(0,gt.dh)(this.separator,t);if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.qp;throw new Error(`Unexpected units ${this.units} .`)}split(t){return this.splitter(t)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ue.Z.HAMMING;switch(this.alphabet){case gt.YI.DNA:case gt.YI.RNA:case gt.YI.PT:}return ue.Z.LEVENSHTEIN}getDistanceFunction(){return ue.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(gt.gp.isHelmCompatible))return"true"===this.column.getTag(gt.gp.isHelmCompatible);const t=(await(0,bt.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),e=new Set(t),n=((0,gt.dh)(this.separator),new Set),i=this.column.length,o=this.column.getRawData();for(let t=0;t<i;++t){const i=o[t];if(!(i in n)){n.add(i);const o=this.getSplitted(t);for(let t=0;t<o.length;++t){const n=o.getCanonical(t);if(!e.has(n))return this.column.setTag(gt.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(gt.gp.isHelmCompatible,"true"),!0}toFasta(t){return t===gt.Hi.FASTA}toSeparator(t){return t===gt.Hi.SEPARATOR}toHelm(t){return t===gt.Hi.HELM}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?wt.b9[gt.Hi.FASTA]:wt.b9[gt.Hi.SEPARATOR]),n||(n=this.toFasta(e)?"":this.separator);const o=t.startsWith("RNA"),r=(0,gt.qp)(t),s=[];for(let t=0;t<r.length;++t){let n=r.getOriginal(t);if(o&&(n=n.replace(yn.EK,"$1")),n===wt.b9[gt.Hi.HELM])s.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join(n)}convert(t,e){const n=this.getJoiner({notation:t,separator:e}),i=this.getNewColumn(t,e);return i.init((t=>{const e=this.getSplitted(t);return n(e)})),i}getRegion(t,e,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const o=t??0,r=e??this.maxLength-1,s=this.getJoiner(),a=r-o+1,l=wt.b9[this.notation];i.init((t=>{const e=this.getSplitted(t),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e.getOriginal(i):l}return s(new Ot.Mu(n,l))}));const c=t=>{const e=t.split(",").map((t=>t.trim())),n=new Array(a);for(let t=0;t<a;++t){const i=o+t;n[t]=i<e.length?e[i]:"?"}return n.join(gt.z1)},h=this.column.getTag(gt.gp.positionNames);h&&i.setTag(gt.gp.positionNames,c(h));const u=this.column.getTag(gt.gp.positionLabels);return u&&i.setTag(gt.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(t){const e=t?t.notation:this.notation,n=t?t.separator:this.separator;let i;const o=this;switch(e){case gt.Hi.FASTA:i=function(t){return o.joinToFasta(t,o.isHelm())};break;case gt.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${e}'.`);i=function(t){return Fi(t,n,o.isHelm())};break;case gt.Hi.HELM:{const t=o.alphabet===gt.YI.DNA||o.alphabet===gt.YI.RNA,e=o.getHelmWrappers();i=function(n){return Di(n,e,t)};break}default:throw new Error(`Unexpected notation '${e}'.`)}return i}getConverter(t,e=void 0){if(t===gt.Hi.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${gt.Hi.SEPARATOR}'.`);const n=this;if(t===gt.Hi.FASTA)return function(t){return n.convertToFasta(t)};if(t===gt.Hi.HELM)return function(t){return n.convertToHelm(t)};if(t===gt.Hi.SEPARATOR)return function(t){return n.convertToSeparator(t,e)};throw new Error}static forColumn(t,e){let n=t.temp[Ut.seqHandler];return n&&n.columnVersion===t.version||(n=t.temp[Ut.seqHandler]=new Gi(t,e)),n}joinToFasta(t,e){const n=new Array(t.length);for(let i=0;i<t.length;++i){const o=t.getOriginal(i);let r=t.getOriginal(i);e&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.FASTA]:o===yn.q7?r="":r.length>1&&(r="["+r+"]"),n[i]=r}return n.join("")}convertToFasta(t){const e=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(t):e(t);return this.joinToFasta(n,this.isHelm())}convertToSeparator(t,e){return Fi(this.isHelm()?this.splitterAsHelmNucl(t):this.splitter(t),e,this.isHelm())}convertToHelm(t){if(this.notation==gt.Hi.HELM)return t;const e=this.getHelmWrappers(),n=t.startsWith("DNA")||t.startsWith("RNA");return Di(this.splitter(t),e,n)}splitterAsHelmNucl(t){const e=this.splitter(t),n=new Array(e.length),i=t.startsWith("DNA"),o=t.startsWith("RNA");for(let t=0;t<e.length;++t){let r=e.getOriginal(t);(i||o)&&(r=r.replace(yn.EK,"$1"),r=r===yn.q7?null:r),n[t]=r||null}return new Ot.Mu(n.filter((t=>!!t)),wt.b9[gt.Hi.HELM])}getRendererBack(t,e){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(t,e)),i}}function Fi(t,e,n){const i=new Array(t.length);for(let e=0;e<t.length;++e){const o=t.getCanonical(e);let r=t.getOriginal(e);n&&(r=r.replace(yn.EK,"$1")),o===wt._S?r=wt.b9[gt.Hi.SEPARATOR]:o===yn.q7&&(r=""),i[e]=r}return i.join(e)}function Di(t,e,n){const[i,o,r,s]=e,a=new Array(t.length);for(let e=0;e<t.length;++e){const i=t.getCanonical(e);let s=t.getOriginal(e);i===wt._S?s=wt.b9[gt.Hi.HELM]:(n&&(s=s.replace(yn.EK,"$1")),s=1===s.length?`${o}${s}${r}`:`${o}[${s}]${r}`),a[e]=s}return`${i}${a.join(".")}${s}`}class Bi{libHelper;rdKitModule;constructor(t,e){this.libHelper=t,this.rdKitModule=e}getSeqHandler(t){return Gi.forColumn(t,this)}getSeqMonomers(t){const e=this.getSeqHandler(t);return Object.keys(e.stats.freq)}async getHelmToMolfileConverter(t){const e=await(0,ke.b2)();return new Hi(e,this.rdKitModule,t)}helmToAtomicLevelSingle(t,e,n,i=!0){if(!t)return bi.vF.createEmpty();const o=e.convertToMolfileV3K([t])[0];if(!o||!o.molfile)return bi.vF.createEmpty();let r=null;try{let t=o.molfile;if(i){if(r=this.rdKitModule.get_mol(t),!r)return bi.vF.createEmpty();r.set_new_coords(),r.normalize_depiction(1),r.straighten_depiction(!0),t=r.get_v3Kmolblock()}return n&&(t=e.molV3KtoMolV3KOCL(t)),new bi.vF(t,o.monomers)}catch(t){const[e,n]=(0,Ct.AP)(t);return io.logger.error(e,void 0,n),bi.vF.createEmpty()}finally{r?.delete()}}async helmToAtomicLevel(t,e,n,i){const o=i??this.libHelper.getMonomerLib(),s=t.dataFrame,l=(0,vi.qj)(s,t.name),c=await this.getHelmToMolfileConverter(o),h=t.toList(),u=new Array(t.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<t.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,e&&!p,!d).molfile;if(d){const e=await d.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n])}if(e&&p){const e=await p.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n]);else r.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",t.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.FASTA)throw new Error(`The column of notation '${gt.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);t.column.meta.units=gt.Hi.FASTA,Gi.setTags(t)}setUnitsToSeparatorColumn(t,e){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.SEPARATOR)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must have the separator tag.`);t.column.meta.units=gt.Hi.SEPARATOR,t.column.setTag(gt.gp.separator,e),Gi.setTags(t)}setUnitsToHelmColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${gt.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);t.column.meta.units=gt.Hi.HELM,Gi.setTags(t)}}async function Vi(t){let e="";try{if(!t||!t.value)return e="No sequence provided",{errorText:e,mol:""};if(!(t.cell&&t.cell.dart&&t.cell.dataFrame&&t.cell.column))return e="Atomic level conversion requeires a sequence column",{errorText:e,mol:""};if(![gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].includes(t.cell.column.meta.units?.toLowerCase()??""))return e="Unsupported sequence notation. please use Bio | Polytool | Convert",{errorText:e,mol:""};const n=(await Tr()).getSeqHandler(t.cell.column);if(!n)return e="No sequence handler found",{errorText:e,mol:""};if((n.getSplitted(t.cell.rowIndex,50)?.length??100)>40)return e="Maximum number of monomers is 40",{errorText:e,mol:""};const i=a.Column.fromStrings("singleVal",[t.value]),o=a.DataFrame.fromColumns([i]);if(Object.entries(t.cell.column.tags).forEach((([t,e])=>{i.setTag(t,e)})),await $o(o,i,t.cell.column.meta.units===gt.Hi.HELM,!1),o.columns.length<2)return e="No structure generated",{errorText:e,mol:""};const r=o.columns.byIndex(1).get(0);return r?{errorText:"",mol:r}:(e="No structure generated",{errorText:e,mol:""})}catch(t){io.logger.error(t)}return e="No Structure generated",{errorText:e,mol:""}}const Wi="#333333",Ui="rgba(60, 177, 115, 0.1)",ji="rgba(240, 240, 240, 0.5)",qi="rgba(100, 100, 100, 0.3)";class zi{constructor(t=Zi.DEFAULT_TRACK_HEIGHT,e=Zi.MIN_TRACK_HEIGHT,n=""){this.ctx=null,this.visible=!0,this.title="",this.tooltipEnabled=!1,this.tooltipContent=null,this.height=t,this.defaultHeight=t,this.minHeight=e,this.title=n}init(t){this.ctx=t}getMonomerAt(t,e,n){return null}enableTooltip(t){this.tooltipEnabled=t}setTooltipContentGenerator(t){this.tooltipContent=t}getTooltipContent(t,e){if(!this.tooltipEnabled||!this.tooltipContent)return null;const n=this.getPositionData(t)??new Map;return this.tooltipContent(t,e,n)}getPositionData(t){return null}setVisible(t){this.visible=t}getHeight(){return this.visible?this.height:0}getDefaultHeight(){return this.defaultHeight}getMinHeight(){return this.minHeight}setHeight(t){this.height=Math.max(this.minHeight,t)}resetHeight(){this.height=this.defaultHeight}isVisible(){return this.visible}setTitle(t){this.title=t}getTitle(){return this.title}}class Yi extends zi{constructor(t=new Map,e=Zi.DEFAULT_TRACK_HEIGHT,n="",i="WebLogo"){super(e,Zi.DEFAULT_TRACK_HEIGHT,i),this.data=new Map,this.monomerLib=null,this.biotype="HELM_AA",this.hoveredPosition=-1,this.hoveredMonomer=null,this.data=t,this.visible=t.size>0}setHovered(t,e){this.hoveredPosition=t,this.hoveredMonomer=e}getPositionData(t){return this.data.get(t)||null}setupDefaultTooltip(){this.enableTooltip(!0),this.setTooltipContentGenerator(((t,e,n)=>this.createTooltipContent(t,e,n)))}createFrequencyTable(t){let e;switch(this.biotype){case"HELM_BASE":case"HELM_SUGAR":case"HELM_NUCLETIDE":e=Ft.o.NUCLEOTIDE;break;default:e=Ft.o.AA}const n=Array.from(t.values()).reduce(((t,e)=>t+e),0),i={};for(const[e,o]of t.entries())i[e]=Math.max(1,Math.round(o/n*100));const o=(0,hi.F)(i,e,this.monomerLib);return o.style.fontSize="11px",o.style.marginTop="4px",o}createTooltipContent(t,e,n){const i=[];if(i.push(s.divText(`Position: ${t+1}`,{style:{fontWeight:"bold",marginBottom:"6px",fontSize:"13px"}})),e&&(i.push(s.divText(`Monomer: ${e}`,{style:{marginBottom:"6px",fontSize:"13px"}})),n.has(e)&&i.push(s.divText(`${(100*n.get(e)).toFixed(2)}%`,{style:{marginBottom:"6px",fontSize:"13px"}}))),n&&n.size>0){const t=this.createFrequencyTable(n);i.push(t)}else i.push(s.divText("No data available",{style:{fontStyle:"italic",color:"#666"}}));const o=s.divV(i);return o.style.maxHeight="80vh",o}setMonomerLib(t){this.monomerLib=t}setBiotype(t){this.biotype=t}getMonomerAt(t,e,n){if(!this.ctx||!this.visible||0===this.data.size)return null;const i=this.data.get(n);if(!i||0===i.size)return null;const o=e,r=Array.from(i.entries()).sort(((t,e)=>e[1]-t[1])),s=r.reduce(((t,[e,n])=>t+n),0),a=this.height;let l=0;for(const[t,e]of r){const n=e*a/s;if(o>=l&&o<l+n)return t;l+=n}return null}updateData(t){this.data=t,this.visible=t.size>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.size)return;const l=Math.floor(n/r),c=i-4,h=e+2;for(let u=0;u<l;u++)this.drawWebLogoColumn(u,t,e,n,i,o,r,s,a,h,c)}drawWebLogoColumn(t,e,n,i,o,r,s,a,l,c,h){const u=r+t-1;if(u<0||u>=a)return;const d=this.data.get(u);if(!d||0===d.size)return;const p=e+t*s,m=s-2;r+t===l&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(p,n,s,o)),this.ctx.fillStyle=ji,this.ctx.fillRect(p+1,c,m,h),this.drawLettersInColumn(u,p,m,c,h,d),this.drawColumnBorder(p,c,m,h)}drawLettersInColumn(t,e,n,i,o,r){const s=Array.from(r.entries()).sort(((t,e)=>e[1]-t[1])),a=s.reduce(((t,[e,n])=>t+n),0),l=Math.min(1,o/(a*o));let c=i;const h=i+o;for(const[i,r]of s){const s=r*o*l,a=Math.max(4,Math.floor(s));if(a<4)continue;const u=t===this.hoveredPosition&&i===this.hoveredMonomer,d=Math.min(a,h-c);if(d<4)break;this.drawLetter(i,e+1,c,n,d,u),c+=d}}drawColumnBorder(t,e,n,i){this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(t+1,e,n,i)}drawLetter(t,e,n,i,o,r=!1){if(!this.ctx)return;const s=this.getMonomerBackgroundColor(t),a=this.getMonomerTextColor(t);this.ctx.fillStyle=s,this.ctx.fillRect(e,n,i,o),r&&(this.ctx.shadowColor="rgba(255, 255, 255, 0.8)",this.ctx.shadowBlur=8,this.ctx.strokeStyle="white",this.ctx.lineWidth=2,this.ctx.strokeRect(e,n,i,o),this.ctx.shadowBlur=0),this.drawLetterSeparators(e,n,i,o),this.drawLetterText(t,e,n,i,o,a)}drawLetterSeparators(t,e,n,i){this.ctx.strokeStyle="rgba(255, 255, 255, 0.4)",this.ctx.lineWidth=1,e+i<e+this.ctx.canvas.height&&(this.ctx.beginPath(),this.ctx.moveTo(t,e+i),this.ctx.lineTo(t+n,e+i),this.ctx.stroke())}drawLetterText(t,e,n,i,o,r){const s=Math.min(.8*o,.8*i);s>=7&&(this.ctx.fillStyle=r,this.ctx.font=`bold ${s}px Roboto, Roboto Local`,this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(t,e+i/2,n+o/2))}getMonomerBackgroundColor(t){if(this.monomerLib)try{const e=this.monomerLib.getMonomerColors(this.biotype,t);if(e&&e.backgroundcolor)return e.backgroundcolor}catch(t){console.warn("Error getting background color from monomerLib:",t)}return"#CCCCCC"}getMonomerTextColor(t){const e=this.getMonomerBackgroundColor(t);try{const t=a.Color.fromHtml(e),n=a.Color.getContrastColor(t);return a.Color.toHtml(n)}catch(t){return console.warn("Error calculating contrast color:",t),"#000000"}}}class Ki extends zi{constructor(t,e=Zi.DEFAULT_TRACK_HEIGHT,n="default",i="Conservation"){super(e,Zi.MIN_TRACK_HEIGHT,i),this.data=t,this.colorScheme=n,this.visible=t.length>0}updateData(t){this.data=t,this.visible=t.length>0}draw(t,e,n,i,o,r,s,a){if(!this.ctx||!this.visible||0===this.data.length)return;const l=Math.floor(n/r);for(let n=0;n<l;n++){const l=o+n;if(l>s)break;const c=t+n*r,h=r,u=c+h/2;l-1<this.data.length&&(this.drawConservationBar(l-1,c,h,u,e,i),l===a&&(this.ctx.fillStyle=Ui,this.ctx.fillRect(c,e,h,i)))}}drawConservationBar(t,e,n,i,o,r){if(!this.ctx)return;const s=this.data[t];this.ctx.fillStyle=ji,this.ctx.fillRect(e+2,o,n-4,r);let a="#3CB173";if("default"===this.colorScheme)s<.5?a="#E74C3C":s<.75&&(a="#F39C12");else if("rainbow"===this.colorScheme)a=s<.2?"#E74C3C":s<.4?"#FF7F00":s<.6?"#FFFF00":s<.8?"#00FF00":"#0000FF";else if("heatmap"===this.colorScheme){const t=Math.round(255*s);a=`rgb(255, ${t}, ${t})`}const l=s*r;this.ctx.fillStyle=a,this.ctx.fillRect(e+2,o+r-l,n-4,l),this.ctx.strokeStyle=qi,this.ctx.lineWidth=1,this.ctx.strokeRect(e+2,o,n-4,r),n>20&&(this.ctx.fillStyle=Wi,this.ctx.font="9px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(`${Math.round(100*s)}%`,i,o+r/2))}}const Zi={TITLE_HEIGHT:16,TRACK_GAP:4,DOTTED_CELL_HEIGHT:30,SLIDER_HEIGHT:8,TOP_PADDING:5,DEFAULT_TRACK_HEIGHT:45,MIN_TRACK_HEIGHT:35},Xi={BASE:Zi.DOTTED_CELL_HEIGHT+Zi.SLIDER_HEIGHT,WITH_TITLE:function(){return this.BASE+Zi.TITLE_HEIGHT+Zi.TRACK_GAP},WITH_WEBLOGO:function(){return this.WITH_TITLE()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP},WITH_BOTH:function(){return this.WITH_WEBLOGO()+Zi.DEFAULT_TRACK_HEIGHT+Zi.TRACK_GAP}};class Ji{constructor(t,e){this.gridColumn=e,this.canvas=null,this.ctx=null,this.tracks=new Map,this.currentHoverPosition=-1,this.currentHoverTrack=null,this.currentHoverMonomer=null,this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.dataFrame=null,this.seqHandler=null,this.seqColumn=null,this.onSelectionCallback=null,this.trackButtons=[],this.userSelectedTracks=null,this.config={x:t.x||0,y:t.y||0,width:t.width||0,height:t.height||0,windowStartPosition:t.windowStartPosition||1,positionWidth:t.positionWidth||15,totalPositions:t.totalPositions||5e3,headerHeight:t.headerHeight||Xi.BASE,sliderHeight:t.sliderHeight||Zi.SLIDER_HEIGHT,currentPosition:t.currentPosition||1,cellBackground:void 0===t.cellBackground||t.cellBackground,sliderColor:t.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:t.onPositionChange||((t,e)=>{}),onHeaderHeightChange:t.onHeaderHeightChange||(()=>{}),...t},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.setupEventListeners(),this.init()}determineVisibleTracks(){const t=this.config.headerHeight,e=this.getTrack("weblogo"),n=this.getTrack("conservation");if(this.tracks.forEach((t=>{t.setVisible(!1),t.setHeight(Zi.DEFAULT_TRACK_HEIGHT)})),!(t<Xi.WITH_TITLE()||t<Xi.WITH_WEBLOGO()))if(t<Xi.WITH_BOTH()){if(e){e.setVisible(!0);const n=t-Xi.WITH_WEBLOGO();e.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}}else{if(e&&e.setVisible(!0),n&&n.setVisible(!0),e&&t>Xi.WITH_BOTH()){const n=t-Xi.WITH_BOTH();e.setHeight(Zi.DEFAULT_TRACK_HEIGHT+n)}this.userSelectedTracks&&(this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]||t.setVisible(!1)})),t<Xi.WITH_WEBLOGO()&&e&&e.setVisible(!1),t<Xi.WITH_BOTH()&&n&&n.setVisible(!1))}}drawTrackButtons(){if(!this.ctx||this.config.width<280)return;this.trackButtons=[];const t=this.getTrack("conservation"),e=this.getTrack("weblogo"),n=t?.isVisible()??!1,i=e?.isVisible()??!1;let o=this.config.width-16;const r=this.config.headerHeight>=Xi.WITH_TITLE()?(Zi.TITLE_HEIGHT-14)/2:2;n&&i||(!n&&t&&(o-=70,this.drawTrackButton("conservation","Conservation",o,r,70,14),o-=4),!i&&e&&(o-=70,this.drawTrackButton("weblogo","WebLogo",o,r,70,14)))}drawTrackButton(t,e,n,i,o,r,s=!1){this.ctx&&(this.trackButtons.push({id:t,label:e,x:n,y:i,width:o,height:r}),this.ctx.fillStyle=s?"rgba(100, 150, 200, 0.8)":"rgba(240, 240, 240, 0.8)",this.ctx.fillRect(n,i,o,r),this.ctx.strokeStyle=s?"rgba(70, 120, 170, 0.8)":"rgba(180, 180, 180, 0.8)",this.ctx.lineWidth=1,this.ctx.strokeRect(n,i,o,r),this.ctx.fillStyle=s?"#ffffff":"#666666",this.ctx.font="9px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e,n+o/2,i+r/2))}handleTrackButtonClick(t,e){for(const n of this.trackButtons)if(t>=n.x&&t<=n.x+n.width&&e>=n.y&&e<=n.y+n.height)return this.snapToTrackHeight(n.id),!0;return!1}isInsideColumnHeaderArea(t,e){return e<(this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0)}snapToTrackHeight(t){let e;if("weblogo"===t)e=Xi.WITH_WEBLOGO();else{if("conservation"!==t)return;e=Xi.WITH_BOTH()}this.userSelectedTracks||(this.userSelectedTracks={},this.tracks.forEach(((t,e)=>{this.userSelectedTracks[e]=!1}))),"conservation"===t?(this.userSelectedTracks.weblogo=!0,this.userSelectedTracks.conservation=!0):"weblogo"===t&&(this.userSelectedTracks.weblogo=!0),this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(e),window.requestAnimationFrame((()=>this.redraw()))}resetToAutoMode(){this.userSelectedTracks=null;const t=this.tracks.size>0?Xi.WITH_BOTH():Xi.BASE;this.config.onHeaderHeightChange&&this.config.onHeaderHeightChange(t),window.requestAnimationFrame((()=>this.redraw()))}drawColumnTitle(t,e,n,i){this.ctx&&i&&this.config.headerHeight>=Xi.WITH_TITLE()&&(this.ctx.fillStyle="rgba(255, 255, 255, 0.95)",this.ctx.fillRect(t,e,n,Zi.TITLE_HEIGHT),this.ctx.fillStyle=Wi,this.ctx.font="bold 13px Roboto, Roboto Local",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(i,t+n/2,e+Zi.TITLE_HEIGHT/2))}clearHoverStates(){(-1!==this.previousHoverPosition||null!==this.previousHoverTrack||null!==this.previousHoverMonomer)&&(this.previousHoverPosition=-1,this.previousHoverTrack=null,this.previousHoverMonomer=null,this.tracks.forEach((t=>{t instanceof Yi&&t.setHovered(-1,null)})),window.requestAnimationFrame((()=>this.redraw())))}redraw(){this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)}setSelectionData(t,e,n,i){this.dataFrame=t,this.seqColumn=e,this.seqHandler=n,this.onSelectionCallback=i||null}setupTooltipHandling(){this.eventElement.addEventListener("mousemove",this.handleTooltipMouseMove.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleTooltipMouseLeave.bind(this))}handleTooltipMouseMove(t){if(!this.isValid)return;const{x:e,y:n}=this.getCoords(t),i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return this.hideTooltip(),void this.clearHoverStates();const a=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,l=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,c=l-Zi.TRACK_GAP;if(n>=l||n<a)return this.hideTooltip(),void this.clearHoverStates();let h=null,u=0;const d=[],p=this.getTrack("weblogo");p&&p.isVisible()&&d.push({id:"weblogo",track:p});const m=this.getTrack("conservation");m&&m.isVisible()&&d.push({id:"conservation",track:m});let f=c;for(const{id:t,track:e}of d){const i=f-e.getHeight();if(n>=i&&n<f){h=t,u=n-i;break}f=i-Zi.TRACK_GAP}let g=null;if(h){const t=this.tracks.get(h);t&&(g=t.getMonomerAt(e,u,r))}if((this.previousHoverPosition!==r||this.previousHoverTrack!==h||this.previousHoverMonomer!==g)&&(this.previousHoverPosition=r,this.previousHoverTrack=h,this.previousHoverMonomer=g,h)){const t=this.tracks.get(h);t instanceof Yi&&(t.setHovered(r,g),window.requestAnimationFrame((()=>this.redraw())))}if((r!==this.currentHoverPosition||h!==this.currentHoverTrack||g!==this.currentHoverMonomer)&&(this.currentHoverPosition=r,this.currentHoverTrack=h,this.currentHoverMonomer=g,h)){const e=this.tracks.get(h);if(e){const n=e.getTooltipContent(r,g);if(n)return void s.tooltip.show(n,t.clientX+16,t.clientY+16)}}h&&g||(this.hideTooltip(),this.clearHoverStates())}handleTooltipMouseLeave(){this.hideTooltip(),this.clearHoverStates(),window.requestAnimationFrame((()=>this.draw(this.config.x,this.config.y,this.config.width,this.config.height,this.config.currentPosition,this.config.windowStartPosition,{preventDefault:()=>{}},this.seqColumn?.name)))}hideTooltip(){this.currentHoverPosition=-1,this.currentHoverTrack=null,s.tooltip.hide()}draw(t,e,n,i,o,r,s,a){if(Object.assign(this.config,{x:t,y:e,width:n,height:i,currentPosition:o,windowStartPosition:r}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(t,e,n,i),this.ctx.translate(t,e),this.ctx.rect(0,0,n,i),this.ctx.clip(),this.determineVisibleTracks();const l=this.config.headerHeight>=Xi.WITH_TITLE();l&&Zi.TITLE_HEIGHT,a&&l&&this.drawColumnTitle(0,0,n,a);const c=i-Zi.SLIDER_HEIGHT,h=c-Zi.DOTTED_CELL_HEIGHT,u=h-Zi.TRACK_GAP,d=[],p=[],m=this.getTrack("weblogo");m&&m.isVisible()&&p.push({id:"weblogo",track:m});const f=this.getTrack("conservation");f&&f.isVisible()&&p.push({id:"conservation",track:f});let g=u;for(const{track:t}of p){const e=t.getHeight(),i=g-e;t.draw(0,i,n,e,this.config.windowStartPosition,this.config.positionWidth,this.config.totalPositions,this.config.currentPosition),d.unshift({y:i,height:e}),g=i-Zi.TRACK_GAP}if(this.drawDottedCells(0,h,n,Zi.DOTTED_CELL_HEIGHT,c),d.push({y:h,height:Zi.DOTTED_CELL_HEIGHT}),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const t=this.config.positionWidth,e=this.config.currentPosition-this.config.windowStartPosition;if(e>=0&&e<Math.floor(n/t)){const n=e*t+t/2;for(let t=0;t<d.length-1;t++){const e=d[t],i=d[t+1];this.ctx.strokeStyle="rgba(60, 177, 115, 0.4)",this.ctx.lineWidth=1,this.ctx.beginPath(),this.ctx.moveTo(n,e.y+e.height),this.ctx.lineTo(n,i.y),this.ctx.stroke()}}}this.drawTrackButtons(),this.ctx.restore(),s.preventDefault(),this.setupEventElement()}drawDottedCells(t,e,n,i,o){if(!this.ctx)return;const r=this.config.totalPositions,s=this.config.positionWidth,a=this.config.currentPosition,l=this.config.windowStartPosition,c=Math.floor(n/s),h=e+Zi.TOP_PADDING;this.drawSlider(t,o,n);for(let n=0;n<c;n++){const c=l+n;if(c>r)break;const u=t+n*s,d=s,p=u+d/2;this.config.cellBackground&&(this.ctx.fillStyle=n%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(u,e,d,i),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(u,e),this.ctx.lineTo(u,o),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(p,h+5,1,0,2*Math.PI),this.ctx.fill(),(c===a||(1===c||c%10==0)&&Math.abs(c-a)>1)&&(this.ctx.fillStyle=Wi,this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(c.toString(),p,h+15)),c===a&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(u,e,d,i))}}drawSlider(t,e,n){if(!this.ctx)return;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(t,e,n,Zi.SLIDER_HEIGHT);const i=Math.floor(n/this.config.positionWidth),o=this.config.windowStartPosition,r=this.config.totalPositions-i,s=this.sliderWidth,a=r<=0?0:(o-1)/r*(n-s),l=r<=0?n:s;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(t+a,e,l,Zi.SLIDER_HEIGHT),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const i=(this.config.currentPosition-1)/(this.config.totalPositions-1),o=Math.round(i*n);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(t+o-1,e-2,3,Zi.SLIDER_HEIGHT+4)}}setupEventElement(){this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(t){const e=this.canvas.getBoundingClientRect();return{x:t.clientX-e.left-this.config.x,y:t.clientY-e.top-this.config.y}}isInHeaderArea(t){const{x:e,y:n}=this.getCoords(t);return e>=0&&e<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(t){this.config.positionWidth=t}isInSliderArea(t){const{y:e}=this.getCoords(t),n=this.config.headerHeight-Zi.SLIDER_HEIGHT;return e>n&&e<n+Zi.SLIDER_HEIGHT}get sliderWidth(){const t=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(t,20)}isInSliderDraggableArea(t){const{x:e,y:n}=this.getCoords(t),i=this.config.headerHeight-Zi.SLIDER_HEIGHT,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition,s=this.config.totalPositions-o,a=s<=0?0:(r-1)/s*(this.config.width-this.sliderWidth);return n>i&&n<i+Zi.SLIDER_HEIGHT&&e>=a&&e<a+this.sliderWidth}setupEventListeners(){this.eventElement.addEventListener("mousemove",(t=>{this.isValid&&(this.isInSliderDraggableArea(t)?this.eventElement.style.cursor="grab":this.isInSliderArea(t)||this.isInHeaderArea(t)?this.eventElement.style.cursor="pointer":this.eventElement.style.cursor="default")})),this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleSelectionClick.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))}handleSelectionClick(t){if(!(this.isValid&&this.dataFrame&&this.seqColumn&&this.seqHandler))return;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return;if(this.isInsideColumnHeaderArea(e,n))return;const i=this.config.positionWidth,o=Math.floor(e/i),r=this.config.windowStartPosition+o-1;if(r<0||r>=this.config.totalPositions)return;const s=this.config.headerHeight>=Xi.WITH_TITLE()?Zi.TITLE_HEIGHT:0,a=this.config.headerHeight-Zi.SLIDER_HEIGHT-Zi.DOTTED_CELL_HEIGHT,l=a-Zi.TRACK_GAP;if(n>=a||n<s)return;let c=null,h=0;const u=[],d=this.getTrack("weblogo");d&&d.isVisible()&&u.push({id:"weblogo",track:d});const p=this.getTrack("conservation");p&&p.isVisible()&&u.push({id:"conservation",track:p});let m=l;for(const{id:t,track:e}of u){const i=m-e.getHeight();if(n>=i&&n<m){c=t,h=n-i;break}m=i-Zi.TRACK_GAP}if(c){const n=this.tracks.get(c);if(n){const i=n.getMonomerAt(e,h,r);if(i){if(this.onSelectionCallback)return void this.onSelectionCallback(r,i);this.selectRowsWithMonomerAtPosition(r,i),t.stopPropagation(),t.stopImmediatePropagation()}}}}selectRowsWithMonomerAtPosition(t,e){if(this.dataFrame&&this.seqHandler)try{const n=this.dataFrame.selection,i=this.seqHandler.getMonomersAtPosition(t,!0);n.init((t=>i[t]===e))}catch(t){console.error("Error selecting rows:",t)}}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("Canvas not found");const t=this.canvas.getContext("2d");t?(this.ctx=t,this.tracks.forEach((e=>e.init(t)))):console.error("Failed to get 2D context from canvas")}addTrack(t,e){this.ctx&&e.init(this.ctx),this.tracks.set(t,e)}removeTrack(t){this.tracks.delete(t)}getTrack(t){return this.tracks.get(t)}updateTrack(t,e){const n=this.getTrack(t);n&&e(n)}get isValid(){const t=this.gridColumn,e=t?.grid,n=e?.horzScroll?.min||0,i=e?.horzScroll?.max||1e7;return!!this.canvas&&!!this.ctx&&this.config.height>=Xi.WITH_TITLE()&&e&&(Qi(t.left??0,n,i)||Qi(t.right??1/0,n,i))}handleMouseDown(t){if(!this.isValid)return;const{x:e}=this.getCoords(t);this.isInSliderDraggableArea(t)&&(this.state.isDragging=!0,this.state.dragStartX=e,this.handleSliderDrag(e),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation())}handleMouseWheel(t){if(this.isValid&&this.isInHeaderArea(t)){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e=t.shiftKey?Math.sign(t.deltaY):Math.sign(t.deltaX||t.deltaY),n=t.shiftKey?3:1,i=this.config.windowStartPosition+e*n,o=Math.floor(this.config.width/this.config.positionWidth),r=this.config.totalPositions-o+1;this.config.windowStartPosition=Math.max(1,Math.min(r,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(t){if(!this.state.isDragging||!this.isValid)return;const e=this.canvas.getBoundingClientRect(),n=t.clientX-e.left-this.config.x;this.handleSliderDrag(n),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}handleKeyDown(t){if(this.isValid&&!(this.config.currentPosition<1)&&document.activeElement?.contains(this.eventElement)&&"block"===this.eventElement.style.display){if("ArrowLeft"===t.key||"ArrowRight"===t.key){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e="ArrowLeft"===t.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+e,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),o=this.config.windowStartPosition;(n<o||n>o+i-1)&&(this.config.windowStartPosition=e<0?n:Math.max(1,n-i+1))}else{if("Escape"!==t.key)return;this.config.currentPosition=-2,t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(t){if(!this.isValid)return;const e=this.sliderWidth,n=this.config.width-e,i=Math.max(0,Math.min(this.config.width,t)),o=Math.floor(this.config.width/this.config.positionWidth),r=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-r,a=Math.max(0,i-e/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(t){this.config.headerHeight=t}handleClick(t){if(!this.isValid)return;t.clientX,this.canvas.getBoundingClientRect().left,t.clientY,this.canvas.getBoundingClientRect().top;const{x:e,y:n}=this.getCoords(t);if(this.handleTrackButtonClick(e,n))return t.preventDefault(),void t.stopPropagation();if(!this.isInsideColumnHeaderArea(e,n)&&n<this.config.headerHeight-Zi.SLIDER_HEIGHT&&n>=0){const t=this.config.positionWidth,n=Math.round(e/t-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(t){Object.assign(this.config,t),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(t){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getHeightThresholds(){return{BASE:Xi.BASE,WITH_TITLE:Xi.WITH_TITLE(),WITH_WEBLOGO:Xi.WITH_WEBLOGO(),WITH_BOTH:Xi.WITH_BOTH()}}}function Qi(t,e,n){return t>=e&&t<=n}class to{static conservationCache=new a.LruCache(100);static webLogoCache=new a.LruCache(100);static lastInvalidationTime=0;static CHUNK_SIZE=50;static clearAllCaches(){to.conservationCache=new a.LruCache(100),to.webLogoCache=new a.LruCache(100),to.lastInvalidationTime=Date.now()}static getLastInvalidationTime(){return to.lastInvalidationTime}static getChunkCacheKey(t,e,n){const i=t.dataFrame;return`${i.id}_${t.name}_f${i.filter.version}_${e}_${n}`}static getConservationChunk(t,e,n,i){return to.conservationCache.getOrCreate(i,(()=>{const o=to.getWebLogoChunk(t,e,n,i),r=new Array(n-e).fill(0);for(let i=e;i<n;i++){const n=o.get(i);if(!n||0===n.size)continue;let s=0,a=0;const l=t.defaultGapOriginal;for(const[t,e]of n.entries())t&&t!==l&&(s+=e,e>a&&(a=e));r[i-e]=s>0?a/s:0}return r}))}static getWebLogoChunk(t,e,n,i){return to.webLogoCache.getOrCreate(i,(()=>{const i=t.column.dataFrame,o=new Map,r=i.filter.trueCount;if(r<=1)return o;for(let t=e;t<n;t++)o.set(t,new Map);const s=i.filter,a=1/r;for(let i=-1;-1!==(i=s.findNext(i,!0));){const r=t.getSplitted(i).getOriginalRegion(e,n);if(0!==r.length)for(let t=0;t<r.length;t++){const n=r[t],i=o.get(e+t);i.set(n,(i.get(n)||0)+a)}}return o}))}static getConservationForViewport(t,e,n,i){const o=new Array(i).fill(0),r=Math.floor(e/to.CHUNK_SIZE)*to.CHUNK_SIZE,s=Math.ceil(n/to.CHUNK_SIZE)*to.CHUNK_SIZE;for(let e=r;e<s;e+=to.CHUNK_SIZE){const n=Math.min(e+to.CHUNK_SIZE,i),r=to.getChunkCacheKey(t.column,e,n),s=to.getConservationChunk(t,e,n,r);for(let t=0;t<s.length&&e+t<i;t++)o[e+t]=s[t]}return o}static getWebLogoForViewport(t,e,n,i){const o=new Map,r=Math.floor(e/to.CHUNK_SIZE)*to.CHUNK_SIZE,s=Math.ceil(n/to.CHUNK_SIZE)*to.CHUNK_SIZE;for(let e=r;e<s;e+=to.CHUNK_SIZE){const n=Math.min(e+to.CHUNK_SIZE,i),r=to.getChunkCacheKey(t.column,e,n),s=to.getWebLogoChunk(t,e,n,r);for(const[t,e]of s.entries())t<i&&o.set(t,e)}return o}}class eo extends Yi{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="WebLogo"){super(new Map,n,"",i),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=to.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=to.getWebLogoForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}class no extends Ki{seqHandler;maxLength;lastViewportStart=-1;lastViewportEnd=-1;lastInvalidationTime=0;forceNextUpdate=!1;constructor(t,e,n=45,i="default",o="Conservation"){super([],n,i,o),this.seqHandler=t,this.maxLength=e,this.visible=t.column.dataFrame.filter.trueCount>1}forceUpdate(){this.forceNextUpdate=!0}resetViewportTracking(){this.lastViewportStart=-1,this.lastViewportEnd=-1}updateForViewport(t,e){const n=to.getLastInvalidationTime(),i=n>this.lastInvalidationTime;if(!(Math.abs(this.lastViewportStart-t)>=10||Math.abs(this.lastViewportEnd-e)>=10||i||this.forceNextUpdate))return;this.forceNextUpdate=!1,this.lastViewportStart=t,this.lastViewportEnd=e,this.lastInvalidationTime=n;const o=Math.max(0,t-20),r=Math.min(this.maxLength,e+20),s=to.getConservationForViewport(this.seqHandler,o,r,this.maxLength);this.updateData(s)}draw(t,e,n,i,o,r,s,a){const l=Math.ceil(n/r)+2,c=Math.min(o+l,s);this.updateForViewport(o-1,c-1),super.draw(t,e,n,i,o,r,s,a)}}const io=new ai;async function oo(){return await dn.getInstance()}class ro{_palette;constructor(t){this._palette=t}get(t){return this._palette[t]}}let so=null;async function ao(){null===so&&(so=async function(){const t="Bio: _package.initBio()";io.logger.debug(`${t}, start`);const e=window.performance.now(),n=await(0,Pt.j)(),i=await io.getProperties(),o=new si(i);io.properties=o;const s=await dn.getInstance(),l=await(0,Nt.ub)();l.explicit&&(l.explicit=[],await(0,Nt.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),u=s.getMonomerSets(),d=window.performance.now();io.logger.debug(`${t}, loading ET: ${d-e} ms`);const p=new Bi(s,n);io.completeInit(p,c,u,n),io.logger.debug(`${t}, end`),function(){const t=t=>{setTimeout((()=>{if(t.isDetached)return;const e=t.dataFrame;if(!e)return;const n=e.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const i of n){let 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S=a.debounce(h.merge(e.onFilterChanged,e.onDataChanged.pipe((0,O.filter)((t=>t?.args?.column===i)))),100).subscribe((()=>{to.clearAllCaches(),C&&(C.resetViewportTracking(),C.forceUpdate()),A&&(A.resetViewportTracking(),A.forceUpdate()),setTimeout((()=>{t.isDetached||t.invalidate()}),50)}));t.sub(S);const x=r=>{const l=[],h=new no(n,b,45,"default","Conservation");A=h,l.push({id:"conservation",track:h,priority:1});const p=new eo(n,b,45,"WebLogo");C=p,r&&(p.setMonomerLib(r),p.setBiotype(n.defaultBiotype||"HELM_AA")),p.setupDefaultTooltip(),l.push({id:"weblogo",track:p,priority:2});const m=new Ji({canvas:t.overlay,headerHeight:w,totalPositions:b+1,onPositionChange:(e,n)=>{setTimeout((()=>{const o=c(),r=u();if(o!==n.start&&i.setTag(gt.gp.positionShift,(n.start-1).toString()),r!==e&&(i.setTag(gt.gp.selectedPosition,e.toString()),e>=0&&!s&&t.tableView&&$()(t.dataFrame?.columns.numerical).find((t=>!0)))){s=!0;const e=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:i.name});t.tableView.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))},onHeaderHeightChange:e=>{t.isDetached||e<v.WITH_TITLE||setTimeout((()=>t.props.colHeaderHeight=e))}},o);m.setupTooltipHandling(),l.forEach((({id:t,track:e})=>{m.addTrack(t,e)})),m.setSelectionData(e,i,n),b>50&&(t.props.colHeaderHeight=w,setTimeout((()=>{t.isDetached||(o.width=400)}),300)),t.sub(t.onCellRender.subscribe((t=>{const e=t.cell;if(!e||!e.isColHeader||e?.gridColumn?.name!==o?.name)return;const n=t.bounds;if(!n)return;m.headerHeight=n.height;const r=d();m.positionWidth=r+8;const s=c();m.draw(n.x,n.y,n.width,n.height,u(),s,t,i.name)})))};(0,bt.pj)().then((t=>{const e=t.getMonomerLib();x(e)})).catch((t=>{r.shell.warning("Failed to initialize monomer library"),console.error("Failed to initialize monomer library:",t)}))}}}),1e3)},e=(r.events.onViewerAdded.subscribe((e=>{if(!(e.args&&e.args.viewer instanceof a.Grid))return;const n=e.args.viewer;t(n)})),r.shell.tableViews);for(const n of e){const e=n?.grid;e&&t(e)}}()}()),await so}function lo(t){const e=new ui(t,io.seqHelper);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();r.shell.error(e)})),e}function co(){return io.monomerLib}function ho(t){return io.seqHelper.getSeqHandler(t)}function uo(t){const e="getRegionTopMenu",n=a.Func.find({package:io.name,name:e});if(1!==n.length)throw new Error(`Package '${io.name}' func '${e}' not found`);const i=n[0].prepare({table:t.dataFrame,sequence:t});return new fi(i,io.seqHelper).widget()}async function po(t){return async function(){const t=s.label("Manage monomer libraries");return mn()(t).addClass("d4-link-action"),t.onclick=async()=>await Bn(),new a.Widget(t)}()}function mo(t){try{new fi(t,io.seqHelper).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;r.shell.error(`Get region editor error: ${e}`),io.logger.error(e,void 0,n)}}function fo(t){const e=new ti;s.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function go(t){const e=new k({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function yo(t){const e=new St({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function bo(){return new Yt}function vo(){return new Yt}function wo(){return new Yt}function Co(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===a.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);let n=io.properties?io.properties.maxMonomerLength:4;if(Rt.gp.maxMonomerLength in t.tags){const e=parseInt(t.getTag(Rt.gp.maxMonomerLength));n=isNaN(e)?n:e}if(".mm.cellRenderer.maxMonomerLength"in t.temp){const e=parseInt(t.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(e)?n:e}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(0==e)setTimeout((()=>{i.value=null}),0);else{const n=e??"",i=null==n?"":n.toString();t.temp[".mm.cellRenderer.maxMonomerLength"]=i,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let o=io.properties?io.properties.fontSize:12;".mm.cellRenderer.fontSize"in t.temp&&t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(o=t.temp[".mm.cellRenderer.fontSize"]);const r=s.input.int("Font Size",{value:o,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(e&&e>0){const n=e??12;t.temp[".mm.cellRenderer.fontSize"]=n,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:t.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.temp[".mm.cellRenderer.settingsChanged"]=Dt.s.true,t.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==t?.temp["color-code"]||t.temp["color-code"],onValueChanged:e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],onValueChanged:e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'});let d=null;(()=>{const e=t.meta.units;return e!==gt.Hi.HELM&&e!==gt.Hi.CUSTOM})()&&(d=s.input.bool("Multiline Rendering",{value:"true"===t.getTag("renderMultiline"),onValueChanged:e=>{t.tags.renderMultiline=e?"true":"false",t.dataFrame.fireValuesChanged()},tooltipText:"Render sequences across multiple lines when they exceed cell width"}));const p=[r,i,l,h,c,u];d&&p.push(d);const m=s.inputs(p);return new a.Widget(m)}(t)}function Ao(t){return function(t,e,n){const i=s.div();i.classList.add("macromolecule-cell-comp-analysis-host");const o=t.cell.column.tags[gt.gp.alphabet],r=o===gt.YI.DNA||o===gt.YI.RNA?Ft.o.NUCLEOTIDE:Ft.o.AA,l={},c=n.getSeqHandler(t.cell.column),h=t.cell.rowIndex,u=c.getSplitted(h);$().count(0).take(u.length).filter((t=>!u.isGap(t))).forEach((t=>{let e=u.getCanonical(t);r===Ft.o.NUCLEOTIDE&&c.isHelm()&&"("===e[1]&&")"===e[e.length-2]&&(e=e.substring(2,e.length-2));const n=l[e]||0;l[e]=n+1}));const d=(0,hi.F)(l,r,e);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),i.appendChild(d),new a.Widget(i)}(t,io.monomerLib,io.seqHelper)}function So(){return new Zt}function xo(t,e,n,i,o){const r=new he.$(i,o,n,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunsch()}function Eo(){return new oe.oP}function To(){return new ce}function Mo(t,e,n,i){return di(t,e??null,n??null,i??null)}async function _o(t,e,n,i,o){const s=di(e,n??null,i??null,o??null);e.dataFrame.columns.add(s),await r.data.detectSemanticTypes(e.dataFrame)}async function Io(t,e,n,i,o,h,u,d,p){if(t!==r.shell.tv.dataFrame)return void r.shell.error(`Table ${t.name} is not a current table view`);if(r.shell.tv,!(0,Zn.V)(e,"Activity Cliffs"))return;const m=_t(t),f={units:e.meta.units,aligned:e.getTag(gt.gp.aligned),separator:e.getTag(gt.gp.separator),alphabet:e.getTag(gt.gp.alphabet)},g=h,y=e,b=async()=>await mt(t,y,m,"Activity cliffs",n,i,g,o,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,u,me,fe,ve,void 0,p),v=o===c.c.UMAP?2e5:2e4,w=o===c.c.UMAP?5e3:2e3;if(t.rowCount>v)return void r.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),A=await new Promise(((e,n)=>{t.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((t=>e(t))).catch((t=>n(t)))})).onCancel((()=>{e(void 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Uint32Array(e.getBuffer().buffer))}return{entries:o,options:{}}}async function Po(t,e,i,o,c,h,u,d,p){if(t.name!==r.shell.tv.dataFrame.name)return void r.shell.error(`Table ${t.name} is not a current table view`);const m=r.shell.tv.dataFrame==t?r.shell.tv:void 0;return(0,Zn.V)(e,"Sequence Space")?(h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(t,e,i,o,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(e.length!==o.length||e.length!==h.length||e.length!==c.length||e.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??r.shell.tableView(t.name)??r.shell.addTableView(t):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const 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Vi(t);if(e.errorText||!e.mol)return a.Widget.fromRoot(s.divText(e.errorText??"No structure generated"));try{const t=a.SemanticValue.fromValueType(e.mol,a.SEMTYPE.MOLECULE),n=s.panels.infoPanel(t);let i=null;n&&(i=a.Widget.fromRoot(n.root));const o=r.chem.drawMolecule(e.mol,300,300,!1);return o.style.cursor="pointer",s.tooltip.bind(o,"Click to expand"),o.onclick=()=>{const t=window.innerWidth-200,n=window.innerHeight-200,i=r.chem.drawMolecule(e.mol,t,n,!1);s.dialog({title:"Molecule"}).add(i).showModal(!0)},i&&i.root.prepend(o),i??a.Widget.fromRoot(o)}catch(t){io.logger.error(t)}return a.Widget.fromRoot(s.divText("No structure generated"))}(t)}async function Oo(t){return async function(t){const e=a.TaskBarProgressIndicator.create("Creating 3D view");let n,i="";try{await(a.Func.find({name:"getPdbHelper"})[0]?.apply({}));try{const o=await Vi(t);if(o.errorText||!o.mol)return n=s.divText(o.errorText??"No structure generated"),e.close(),new a.Widget(n);const l=o.mol;i=await r.functions.call("Bio:Embed",{molecule:l});const c=wi.Molecule.fromMolfile(i);c?i=c.toMolfile():console.warn("Failed to convert molv3 to molv2")}catch(t){console.warn(t)}try{i=i.replaceAll("\\n","\n");const t=new Blob([i],{type:"text/plain"}),e=s.div([],{classes:"d4-ngl-viewer",id:"ngl-3d-host"});e.style.setProperty("height","100%","important");const o=new NGL.Stage(e,{backgroundColor:"white"});o.loadFile(t,{ext:"sdf"}).then((function(t){o.setSize(300,300),t.addRepresentation("ball+stick"),t.autoView()})),n=s.div([e],{style:{aspectRatio:"1"}})}catch(t){n=s.divText("Couldn't get 3D structure")}}catch(t){n=s.divText("Couldn't get 3D structure")}return e.close(),new a.Widget(n)}(t)}function Ho(){(0,Jn.D)({},io.seqHelper).catch((t=>{const[e,n]=(0,Ct.AP)(t);if(t instanceof Xn.Ap)return r.shell.warning(t.element),void io.logger.warning(e);r.shell.error(e),io.logger.error(e,void 0,n)}))}async function Go(t=null,e=null,n){return(0,Jn.D)({col:t,clustersCol:e,...n},io.seqHelper)}async function Fo(){const t=r.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==a.SEMTYPE.MACROMOLECULE&&(io.seqHelper.getSeqHandler(t),!0))),n=async e=>{if(!(0,Zn.V)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});r.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>io.seqHelper.getSeqHandler(t).isMsa())),o=s.input.choice("Column",{value:i?i.name:t[0],items:t});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([o])).onOK((async()=>{const t=e.find((t=>t.name==o.value))??null;t&&await n(t)})).show()}else i=e[0];i&&await n(i)}else r.shell.error("Current table does not contain sequences")}function Do(t){return new yt.m(t).importFasta()}function Bo(t){return console.log(t),[]}function Vo(){const t=(0,$t.me)()[0];(0,Te.C)(t,io.seqHelper)}function Wo(t){(0,Te.C)(t,io.seqHelper)}function Uo(){return new oi}async function jo(t){const e=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await r.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const o=[];for(const s of n)try{const e=await r.dapi.files.readAsText(t+s.fullPath),n=a.DataFrame.fromCsv(e);for(const t of n.columns)await r.functions.call("Bio:detectMacromolecule",{col:t})===a.SEMTYPE.MACROMOLECULE&&o.push({file:s.path,result:"detected",column:t.name,message:`units: ${t.meta.units}`})}catch(t){o.push({file:s.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/n.length,`Test ${s.fileName}`)}r.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const s=a.DataFrame.fromObjects(o);return s.name=`datasets_detectMacromolecule_${t}`,s}async function qo(t,e){return await async function(t,e){if(await(0,te.cb)(10),!(0,Zn.V)(e,"Sequence space"))return t;const n=io.seqHelper,i=(0,vt.R)(e,n);i.name="splitToMonomers";const o=e.dataFrame;for(const t of i.columns)t.semType=Wt.uF.MONOMER,t.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=t=>{s.lastIndex=0;const e=t.match(s);return e?`${e[1]} (${parseInt(e[2]??"0")+1})`:t};for(let t=0;t<i.columns.length;t++){const n=i.columns.byIndex(t);n.semType=Wt.uF.MONOMER,n.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const r=100;let s=0;for(;o.columns.byName(n.name)&&s<r;)n.name=l(n.name),s++;o.columns.add(n)}await r.data.detectSemanticTypes(o);for(let t=0;t<i.columns.length;t++){const e=i.columns.byIndex(t);e.setTag(a.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return o}(t,e)}function zo(t){return io.seqHelper.getSeqMonomers(t)}function Yo(){return new Se(io.seqHelper)}function Ko(){const t=r.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Zo(){return new xe(io.seqHelper)}function Xo(){const t=r.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Jo(t){const e=(0,$t.me)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new pe.a7(e,io.seqHelper)}function Qo(t){r.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),r.shell.tv.grid.scrollToCell(t,0)}async function tr(t,e,n){const i=io.seqHelper;return yi(t,e,n,ft.IDENTITY,i)}async function er(t,e,n){const i=io.seqHelper;return yi(t,e,n,ft.SIMILARITY,i)}async function nr(){Bn()}async function ir(){await Vn()}async function or(){const t=await Tn.getInstance();await t.getViewRoot()}async function rr(){return await Vn(!1)}async function sr(t,e){(await(await dn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((e=>{const n=e.endsWith(".json")?e.substring(0,e.length-5):e;t.item(n).onSelected.subscribe((async()=>{const t=await Tn.getInstance();await t.getViewRoot(e,!0),t.resetCurrentRowFollowing()}))}))}function ar(){(0,Me.TE)()}function lr(){return new _e._i(io.seqHelper,io.logger)}function cr(){return new _e._i(io.seqHelper,io.logger)}async function hr(){const t=a.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoLargeApp"),n=await io.files.readCsv("data/sample_PT_100000x5.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function ur(){const t=a.TaskBarProgressIndicator.create("WebLogo ...");try{const t=new URLSearchParams(window.location.search),e=new Qn(t,"webLogoAggApp"),n=await io.files.readCsv("samples/FASTA_PT_activity.csv");await r.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function dr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new mi(t,"getRegionApp");await e.init()}finally{t.close()}}async function pr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await io.files.readCsv("samples/HELM_empty_vals.csv"),n=new mi(t,"getRegionHelmApp");await n.init({df:e,colName:"HELM"})}finally{t.close()}}function mr(){const t=a.DataFrame.fromColumns((0,Lt.dW)());r.shell.addTableView(t)}function fr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(io.seqHelper,gt.Hi.FASTA)]);r.shell.addTableView(t)}function gr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(io.seqHelper,gt.Hi.HELM)]);r.shell.addTableView(t)}function yr(t,e){!function(t,e,n){const i=Object.values(gt.Hi).filter((t=>t!==gt.Hi.CUSTOM));e.group("Copy").items(i,(e=>{const i=t.column,o=t.rowIndex,s=n.getSeqHandler(i),a=e===gt.Hi.SEPARATOR?io.properties.defaultSeparator??"-":void 0,l=s.getJoiner({notation:e,separator:a})(s.getSplitted(o));navigator.clipboard?(navigator.clipboard.writeText(l),r.shell.info(`Value of notation '${e}' copied to clipboard`)):r.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e,io.seqHelper)}async function br(){await async function(){const t=await io.files.readCsv("samples/peptides-non-natural.csv");t.name="Similarity and Diversity Demo",t.col("activity").setTag("format","3 significant digits"),t.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const e=r.shell.addTableView(t);await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const n=e.addViewer("Sequence Similarity Search",{limit:20}),i=e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,$t.Kd)(e.grid,"sequence",500,30);const o=e.addViewer("Sequence Diversity Search",{limit:20});e.dockManager.dock(o,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),r.functions.call("Dendrogram:HierarchicalClustering",{df:r.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function vr(){await async function(){const t=await r.functions.eval("Bio:SeqSpaceDemo"),e=await r.dapi.projects.find(t.id);await e.open(),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function wr(){await async function(){const t=await io.files.readCsv("tests/helm_cyclic_cliffs.csv");t.name="Activity Cliffs Demo",await r.data.detectSemanticTypes(t),await t.meta.detectSemanticTypes();const e=r.shell.addTableView(t);s.setUpdateIndicator(e.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await Io(t,t.getCol("Sequence"),t.getCol("Activity"),96,c.c.UMAP,ue.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),mn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),e.grid.props.rowHeight=180,e.grid.col("sequence")&&(e.grid.col("sequence").width=300),e.grid.col("structure")&&(e.grid.col("structure").width=300);const o=Array.from(e.viewers).find((t=>t!==e.grid&&t.type===a.VIEWER.GRID));o&&(o.props.rowHeight=40,o.col("seq_diff").width=600,e.dockManager.dock(o,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(t){!function(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;r.shell.error(e),io.logger.error(t.message,void 0,n)}(t)}finally{s.setUpdateIndicator(e.root,!1)}r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function Cr(){await async function(){const t=await io.files.readCsv("samples/HELM_BI_CYCLIC.csv");t.name="To Atomic Level",await t.meta.detectSemanticTypes(),await r.data.detectSemanticTypes(t);const e=r.shell.addTableView(t),n=t.col("HELM");await $o(t,n,!0,!1),(0,$t.Kd)(e.grid,"molfile(HELM)",500,300,!0),(0,$t.Kd)(e.grid,"HELM",500,void 0,!0),r.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),r.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function Ar(t){const e=(0,bt.uX)(t),n=JSON.stringify(e);a.Utils.download(`${t.name}.json`,n)}async function Sr(t,e){if(!t.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[t]),i=a.DataFrame.fromColumns([n]),o=await r.functions.call("Bio:detectMacromolecule",{col:n});o&&(n.semType=o);const s=(await oo()).getMonomerLib(),l=io.seqHelper,c=await(0,Pt.j)(),h=(await(0,gi.V)(i,n,e,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(t){const[e,n]=(0,Ct.AP)(t);throw io.logger.error(e,void 0,n),t}}async function xr(t,e){if(!t.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[t]),i=a.DataFrame.fromColumns([n]);if(!await r.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await yi(i,n,e,ft.IDENTITY,io.seqHelper)).get(0)}catch(t){const[e,n]=(0,Ct.AP)(t);throw io.logger.error(e,void 0,n),t}}async function Er(t,e,n){const i=await t.readAsString();await async function(t,e,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let o=0;const s=await r.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(t),u=e?h.getCol(e):h.columns.byIndex(0);await r.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-o>=.1&&(o=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,te.cb)(0))}l>0?r.shell.warning(`detectMacromolecule failed ${l} / ${n}`):r.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,e,n)}async function Tr(){return await ao(),io.seqHelper}function Mr(t,e,n){return async function(t,e,n=!0,i){const o=io.seqHelper,r=(await o.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(e,n,io.rdKitModule,i);return 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t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",r="";const s=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=r+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=r+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:r+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:r+i);const o=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[o][e].parentJ}return new o(n,i,s)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let o=1;o<=this.len2;o++)this.fillOne(i,o),this.dpGrid[i][o].value<=0?(this.dpGrid[i][o].value=0,this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0):0==this.dpGrid[this.dpGrid[i][o].parentI][this.dpGrid[i][o].parentJ].value&&(this.dpGrid[i][o].parentI=0,this.dpGrid[i][o].parentJ=0),this.dpGrid[i][o].value>t&&(t=this.dpGrid[i][o].value,e=i,n=o);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.setMethod(i),this.setSequences(t,e),this.setGap(n)}}},4954:(t,e,n)=>{"use strict";n.d(e,{a7:()=>m,if:()=>g,BQ:()=>y,nI:()=>f});var i=n(4328),o=n(7389),r=n(6082),s=n(8070),a=n(2003),l=n(439);const c=31;async function h(t,e,n=!1,o){const s=e.getSeqHandler(t);let a;o??=new Map;const l=s.isHelm()?e.getSeqMonomers(t):Object.keys(s.stats.freq).filter((t=>""!==t));for(let t=0;t<l.length;t++)o.has(l[t])||o.set(l[t],`${o.size+1}`);if(s.isHelm())a=await i.functions.call("HELM:getMolFiles",{col:t}),a=function(t,e,n=!1){const i=new Array(t.length);for(let o=0;o<t.length;o++){let r=0,s=0,a="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const l=t.get(o);r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1,r=l.indexOf("\n",r)+1;const h=parseInt(l.substring(r,r+3)),u=parseInt(l.substring(r+3,r+6));a+=`M  V30 COUNTS ${h} ${u} 0 0 0\n`,a+="M  V30 BEGIN ATOM\n";for(let t=0;t<h;t++){r=l.indexOf("\n",r)+1+c,s=l.indexOf(" ",r);const i=l.substring(r,s);a+=n?`M  V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}a+="M  V30 END ATOM\n",a+="M  V30 BEGIN BOND\n";for(let t=0;t<u;t++){r=l.indexOf("\n",r)+1;const e=parseInt(l.substring(r,r+3).trim()),n=parseInt(l.substring(r+3,r+6).trim());a+=`M  V30 ${t+1} ${parseInt(l.substring(r+6,r+9).trim())} ${e} ${n}\n`}a+="M  V30 END BOND\n",a+="M  V30 END CTAB\n",a+="M  END",i[o]=a}return i}(a,o,n);else{a=new Array(t.length);for(let e=0;e<t.length;e++){const t=u(s.getSplitted(e),o,n);a[e]=t}}return r.Column.fromStrings("monomericMols",a)}function u(t,e,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let o=0;o<t.length;o++){const r=t.getCanonical(o);r!==l._S&&(i+=n?`M  V30 ${o+1} R${e.get(r)} 0.000 0.000 0 0\n`:`M  V30 ${o+1} At 0.000 0.000 0 0 MASS=${e.get(r)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M  V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}var d=n(4870);const p="substr_helm";class m{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(t,e){this.seqHelper=e,this.col=t[0],this.createUI()}editHelmLinkAction(){(0,d.Ku)(this.inputsDiv,this.grid.root),o.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(p,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===a.Hi.HELM?o.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?o.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):o.inputs([this.columnsInput,this.substructureInput]);(0,d.Ku)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame;this.columnsInput=o.input.column("Column",{table:t,value:this.col,onValueChanged:t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()},filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE}),this.substructureInput=o.input.string("Substructure",{value:""}),this.editHelmLink=o.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const e=r.DataFrame.create(1);e.columns.addNewString(p).init((t=>"")),e.col(p).semType=this.col.semType,e.col(p).meta.units=a.Hi.HELM,this.grid=e.plot.grid(),this.separatorInput=o.input.string("Separator",{value:this.separator}),this.inputsDiv=o.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=o.dialog("Substructure Search").add(o.divV([o.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,n=this.units===a.Hi.HELM?e.get(p,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),t=this.units===a.Hi.HELM?await g(n,this.col,this.seqHelper):f(n,this.col),this.col.dataFrame.filter.and(t)})).show()}}function f(t,e,n){const i=n?function(t,e){const n=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,o=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?o?`${n}${r}${n}`:`${n}${r}${n}|${n}${r}$`:o?`^${r}${n}|${n}${r}${n}`:`^${r}${n}|${n}${r}${n}|${n}${r}$`}(t,n):t,o=r.BitSet.create(e.length);for(let n=0;n<e.length;n++){const r=e.get(n);(r.match(i)||r===t)&&o.set(n,!0,!1)}return o}async function g(t,e,n){e.version!==e.temp["last-invalidated-version"]&&await y(e,n,!0);const o=r.Column.string("helm",1).init((e=>t));o.semType=r.SEMTYPE.MACROMOLECULE,o.meta.units=a.Hi.HELM;const s=await h(o,n,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function y(t,e,n){const i=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);try{await(0,s.cb)(10);const i=new Map,o=await h(t,e,n,i);t.temp["monomeric-mols"]=o,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version}finally{i.close()}}},966:(t,e,n)=>{"use strict";n.d(e,{V:()=>s,l:()=>a});var i=n(4328),o=n(6082),r=n(6723);function s(t,e,n=[],o=[],s=!0){const l=r._package.seqHelper,[c,h]=a(t,e,l,n,o);return s&&!c&&i.shell.warning(h),c}function a(t,e,n,r=[],s=[]){let a=!0,l="";if(t.semType!==o.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(t),o=i.notation;if(r.length>0&&!r.some((t=>o.toUpperCase()==t.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==r.length?"any notation":`notation${r.length>1?"s":""} ${r.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const t=i.alphabet;s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(t,e,n)=>{"use strict";n.d(e,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>r});var i,o,r,s,a,l=n(8152);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(o||(o={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(s||(s={})),function(t){t.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(t,e,n)=>{"use strict";n.d(e,{C:()=>u});var i=n(6082),o=n(7389),r=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(t,e){let n=t??r.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=e.getSeqHandler(n),u=s.notation;const d=o.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=o.input.column("Column",{table:r.shell.t,value:n,filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:t=>(n=t,s=e.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((t=>t!==u)),v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(o.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((t=>t!==u));const y=o.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=o.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=o.dialog("Convert Sequence Notation").add(o.div([d,m.root,v.root,y.root])).onOK((async()=>{const t=v.value,i=t===l.Hi.SEPARATOR?y.value:void 0;await async function(t,e,n,i){const o=e.getSeqHandler(t).convert(n,i);t.dataFrame.columns.add(o);const s=await r.functions.call("Bio:detectMacromolecule",{col:o});return s&&(o.semType=s),await r.data.detectSemanticTypes(t.dataFrame),o}(n,e,t,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((t=>{h.forEach((t=>{t.unsubscribe()})),h=[],c=null}))))}},536:(t,e,n)=>{"use strict";n.d(e,{Z:()=>o});var i=n(6956);class o{constructor(t){const e=t.split(i.xe).filter((t=>t));e.forEach((t=>this.validateConnectionItem(t))),this.connectionItems=e}connectionItems;validateConnectionItem(t){const e="(PEPTIDE|RNA)",n=new RegExp(`${e}[0-9]+,${e}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!t.match(n))throw new Error(`Cannot parse connection item from ${t}`)}getConnectionData(){const t=[];return this.connectionItems.forEach((e=>{const n=[],i=e.split(",");i[2].split("-").forEach(((t,e)=>{const o=i[e],r=t.split(":"),s={monomerIdx:parseInt(r[0])-1,rGroupId:parseInt(r[1].slice(1))};n.push({polymerId:o,bond:s})})),t.push(n)})),t}}},6956:(t,e,n)=>{"use strict";n.d(e,{mP:()=>r,pk:()=>o,xe:()=>i});const i="|",o="$",r="H"},9099:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(536),o=n(6956),r=n(9034);class s{helmString;constructor(t){this.helmString=t;const e=this.helmString.split(o.pk),n=e[0].split(o.xe);this.simplePolymers=n.map((t=>new r.d(t))),this.connectionList=new i.Z(e[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const t=this.simplePolymers.map((t=>t.monomers.length)).reduce(((t,e)=>t+e),0),e=Array.from({length:t},(()=>[]));return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e[n].push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(t){return this.getSimplePolymerByMonomerIdx(t).polymerType}getSimplePolymerByMonomerIdx(t){const e=this.getMonomerIdxShifts(),n=Object.values(e).sort(((t,e)=>t-e)).find((e=>t>=e));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${t}`);const i=Object.keys(e).find((t=>e[t]===n));return this.simplePolymers.find((t=>t.id===i))}shiftBondMonomerIds(t,e){e.forEach((e=>{e.forEach((e=>{e.monomerIdx+=t}))}))}getMonomerIdxShifts(){const t={};let e=0;return this.simplePolymers.forEach((n=>{t[n.id]=e,e+=n.monomers.length})),t}getBondData(){const t=this.getMonomerIdxShifts(),e=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),o=t[n.id];this.shiftBondMonomerIds(o,i),e.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((e=>{const n=t[e.polymerId],o=e.bond;o.monomerIdx+=n,i.push(o)})),e.push(i)})),e}}},9034:(t,e,n)=>{"use strict";n.d(e,{d:()=>o});var i=n(8438);class o{simplePolymer;isNucleotideSequence=!1;constructor(t){this.simplePolymer=t,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:e,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=e,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const t=new RegExp("(PEPTIDE|RNA)[0-9]+{"),e=this.simplePolymer.match(t);if(!e)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return e[1]}getIdx(){const t=new RegExp(`${this.polymerType}([0-9]+){`),e=this.simplePolymer.match(t);if(!e)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(e[1])}getMonomerSymbolsAndTypes(){const t=new 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e=y(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,N.vA)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class ${constructor(t="categorial"){this.aa2num=P.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,n=t.length;const i=["NH2","COOH"];if(t.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==t[n],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=n}if(t.endsWith(i[1])){const e=i[1].length+1;(0,N.vA)("-"==t[n-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),n-=e}return t.substring(e,n)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return $._dropDefises($._truncateSequence(t))}encode(t){const e=t.length,n=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,N.vA)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),n[i]=this.encodeLettter(e)}return n}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let n=0;n<t.length;++n){const i=t[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var R=n(4139);const k="input.fa",O="result.fasta";class H extends Error{element;constructor(t,e){super(t.innerText,e),this.element=t}}function G(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}async function F(t,e,n=!1,i="",r=null,s,c,h,u){let d=e.toList();n&&(d=d.map((t=>$.clean(t).replace(/\-/g,""))));const p=e.length;r??=o.Column.string("Clusters",p).init("0"),r.type!=o.COLUMN_TYPE.STRING&&(r=r.convertTo(o.TYPE.STRING)),r.compact();const m=r.categories,f=r.getRawData(),g=new Array(m.length),y=new Array(m.length);if(u){const e=t.selection;if(0===e.length)throw new Error("No selected rows in the table.");for(let t=-1;-1!==(t=e.findNext(t,!0));){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}}else for(let t=0;t<p;++t){const e=f[t];(g[e]??=[]).push(d[t]),(y[e]??=[]).push(t)}B(y,m);const b=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),v=o.Column.string(i,p);for(let t=0;t<m.length;++t){const e=g[t];if(!e||0===e.length)continue;const n=G(e);await b.fs.writeFile(k,n);const i=`${void 0!==s?` --gpo ${s}`:""}${void 0!==c?` --gpe ${c}`:""}${void 0!==h?` --tgpe ${h}`:""}`,o=await b.exec(`kalign ${k} -f fasta -o ${O}${i}`);console.warn(o);const r=await b.cat(O);if(!r){const t=D(o,1);throw new Error(t)}const l=new a.m(r).sequencesArray,u=y[t];for(let t=0;t<l.length;++t)v.set(u[t],l[t])}const w=e.meta.units,C=e.getTag(l.gp.alphabet);return v.meta.units=w,v.setTag(l.gp.aligned,"SEQ.MSA"),v.setTag(l.gp.alphabet,C),v.semType=o.SEMTYPE.MACROMOLECULE,v}function D(t,e){const n=[],i=/^.+ERROR : (.+)$/gm;let o;for(;null!=(o=i.exec(t))&&(void 0===e||n.length<e);)n.push(o[1]);return n.join("\n")}function B(t,e){const n=t.map(((t,e)=>[t,e])).filter((([t,e])=>1==t.length)).map((([t,e])=>e));if(n.length>0){const t=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((t=>{let o=e[t];return o.length>25&&(o=o.slice(0,25)+"..."),i.divText(`"${o}"${t<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new H(t)}}},8152:(t,e,n)=>{"use strict";n.d(e,{GD:()=>d,ZY:()=>h});var i=n(4328),o=n(6082),r=n(2003),s=n(608),a=n(4139),l=n(6723);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],u=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(t,e,n,i="ginsi",l=1.53,h=0,d=null,m,f=!1){const g=await c.getDockerContainer(),y=e.length;d??=o.Column.int("Clusters",y).init(0),d.type!=o.COLUMN_TYPE.STRING&&(d=d.convertTo(o.TYPE.STRING));const b=d.categories,v=d.getRawData(),w=new Array(b.length),C=new Array(b.length);if(f){const n=t.selection;for(let t=-1;-1!==(t=n.findNext(t,!0));){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}}else for(let t=0;t<y;++t){const n=v[t];if(!b[n])continue;const i=n,o=e.get(t);o&&((w[i]??=[]).push({ID:t.toString(),HELM:o}),(C[n]??=[]).push(t))}(0,s.aZ)(C,b);const A=new 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w,C,A=n(6307);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new r.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class S{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(t=0,e){this.value=this.rowCount=t,this.bounds=e}push(t){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=t,++this.valueIdx}aggregate(t){this.value=t(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(t,e,n,i){this.pos=t,this.name=e,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new S),e}aggregate(t){const e=function(t){return e=>{const n=function(t){let e;const n="agg";return e=t instanceof Float32Array?r.Column.fromFloat32Array(n,t):t instanceof Int32Array?r.Column.fromInt32Array(n,t):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,t),e}(e);return n.aggregate(t)}}(t);for(const[t,n]of Object.entries(this._freqs))n.aggregate(e)}getMinValue(){return Math.min(...Object.values(this._freqs).map((t=>t.value)))}calcPlotValue(t){for(const e of Object.values(this._freqs))e.plotValue=e.value-t}calcHeights(t){this.sumPlotValue=0;for(const t of Object.values(this._freqs))this.sumPlotValue+=t.plotValue;if(this.sumPlotValueForHeight=0,t===d.fH.Entropy){const t=Object.keys(this._freqs).length,e=.01*this.sumPlotValue,n=e/t;for(const t of Object.values(this._freqs)){const i=(t.plotValue+n)/(this.sumPlotValue+e);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(t===d.fH.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=t}}calcScreen(t,e,n,i,o,s,a,l,c){const h=i===d.fH.Entropy?n*(o-this.sumPlotValueForHeight)/o:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort(((t,e)=>t[0]!==g._S&&e[0]!==g._S?e[1].value-t[1].value:t[0]===g._S&&e[0]===g._S?0:t[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((t-e)*l*s,u,a*l,n),u+=n}}render(t,e,n,i,o,r,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;r&&(p=r.getMonomerTextColor(o,a)),t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(d,h.top,h.width,h.height),t.fillStyle=p,t.textAlign="left",t.font=e;const m=t.measureText(c);t.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),t.fillText(c,0,-n)}}getMonomerAt(t,e){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(t,e)));return n?n[0]:void 0}buildCompositionTable(t,e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol 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E=d.Fo;var T;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(T||(T={}));const M=new class{render=20};class _ extends r.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=b._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(C.sequenceColumnName,E.sequenceColumnName,{category:w.DATA,semType:r.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const t=[r.AGG.KEY,r.AGG.PIVOT,r.AGG.MISSING_VALUE_COUNT,r.AGG.SKEW,r.AGG.KURT,r.AGG.SELECTED_ROWS_COUNT],e=Object.values(r.AGG).filter((e=>!t.includes(e)));this.valueColumnName=this.string(C.valueColumnName,E.valueColumnName,{category:w.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(C.valueAggrType,E.valueAggrType,{category:w.DATA,choices:e,description:"Aggregation method for value column"}),this.startPositionName=this.string(C.startPositionName,E.startPositionName,{category:w.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(C.endPositionName,E.endPositionName,{category:w.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(C.skipEmptySequences,E.skipEmptySequences,{category:w.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(C.skipEmptyPositions,E.skipEmptyPositions,{category:w.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(C.shrinkEmptyTail,E.shrinkEmptyTail,{category:w.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(C.backgroundColor,E.backgroundColor,{category:w.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(C.positionHeight,E.positionHeight,{category:w.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(C.positionWidth,E.positionWidth,{category:w.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(C.verticalAlignment,E.verticalAlignment,{category:w.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(C.horizontalAlignment,E.horizontalAlignment,{category:w.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(C.fixWidth,E.fixWidth,{category:w.LAYOUT,userEditable:!1}),this.fitArea=this.bool(C.fitArea,E.fitArea,{category:w.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(C.minHeight,E.minHeight,{category:w.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(C.maxHeight,E.maxHeight,{category:w.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(C.maxMonomerLetters,E.maxMonomerLetters,{category:w.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(C.showPositionLabels,E.showPositionLabels,{category:w.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(C.positionMarginState,E.positionMarginState,{category:w.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(C.positionMargin,n,{category:w.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(C.filterSource,E.filterSource,{category:w.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=o.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=o.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,b.getMonomerLibHelper)().then((t=>{this.monomerLib=t.getMonomerLib(),this.render(T.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(T.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(b._package.logger)}static viewerCounter=-1;viewerId=++_.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const t=`${this.toLog()}.setData()`;b._package.logger.debug(`${t}, in`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),b._package.logger.debug(`${t}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,b._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";b._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(r.debounce(this.renderRequest,M.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=o.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=o.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=o.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,o.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(T.Freqs,"buildView"),b._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(t){const e={width:t.target.clientWidth,height:t.target.clientHeight};this.lastSize.width==e.width&&this.lastSize.height==e.height||(b._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(e)}, start `),this.render(T.Layout,"rootOnSizeChanged")),this.lastSize=e}updateEditors(){this.props.getProperty(C.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((t=>t.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(T.Freqs,"updateSeqCol()"),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let t;switch(this.filterSource){case d.lT.Filtered:t=this.dataFrame.filter;break;case d.lT.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=n*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;let e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e);this.fitArea&&e<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/e),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const o=e>n;if(this.setSliderVisibility(o),o){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*t,this.canvas.height=i*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,o=this.root.clientHeight/n,r=Math.max(1,Math.min(i,o));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}safeUpdateSlider(t,e,n,i){v(t,this.slider.minRange,.1)&&v(e,this.slider.maxRange,.1)&&v(n,this.slider.min,.1)&&v(i,this.slider.max,.1)||this.slider.setValues(t,e,n,i)}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case C.sequenceColumnName:this.updateSeqCol();break;case C.sequenceColumnName:case C.startPositionName:case C.endPositionName:case C.filterSource:case C.shrinkEmptyTail:case C.skipEmptyPositions:case C.positionHeight:case C.valueColumnName:case C.valueAggrType:this.render(T.Freqs,`onPropertyChanged( ${t.name} )`);break;case C.minHeight:case C.maxHeight:case C.maxMonomerLetters:case C.positionWidth:case C.showPositionLabels:case C.fixWidth:case C.fitArea:case C.horizontalAlignment:case C.verticalAlignment:case C.positionMargin:case C.positionMarginState:this.render(T.Layout,`onPropertyChanged(${t.name})`);break;case C.backgroundColor:this.render(T.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){b._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const t=`${this.toLog()}.detach()`;b._package.logger.debug(`${t}, in`);const e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),e())})),b._package.logger.debug(`${t}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const n=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),o=this.positions[i];if(!o)return[null,null,null];const r=o.getMonomerAt(n,t.y);return void 0===r?[o,null,null]:[o,r,o.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((t=>!t.hasMonomer(g._S)||t.getFreq(g._S).rowCount!==t.sumRowCount)).toArray())}requestedRenderLevel=T.Freqs;renderRequest=new h.Subject;renderRequestSub;render(t,e){b._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(b._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(t>=T.Freqs&&(()=>{if(b._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.seqCol.getTag(u.gp.positionNames),e=this.seqCol.getTag(u.gp.positionLabels);let n;!t&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):t&&this.endPositionName&&(n=t.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),o=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((t=>{const e=this.seqHandler.getSplitted(t,n);return i.get(t)&&e?e.length:0})).reduce(((t,e)=>Math.max(t,e)),0);this.positionNames=t?t.split(u.z1).map((t=>t.trim())):[...Array(o).keys()].map((t=>`${t+1}`)),this.positionLabels=e?e.split(u.z1).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):o-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let t=0;t<s;t++){const e=this.positionNames[this.startPosition+t],n=this.positionLabels?this.positionLabels[this.startPosition+t]:void 0;this.positions[t]=new x(this.startPosition+t,e,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let t=0;t<s;++t){for(const e of l){const n=this.seqHandler.getSplitted(e),i=t+this.startPosition<n.length?n.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===i?g._S:i,r=this.positions[t],s=r.getFreq(o);++r.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===r.AGG.TOTAL_COUNT)continue;let e=null;try{e=this.dataFrame.getCol(this.valueColumnName),e.matches("numerical")||(e=null)}catch{e=null}if(e){for(const n of l){const i=this.seqHandler.getSplitted(n),o=t+this.startPosition<i.length?i.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===o?g._S:o,s=e.get(n);this.positions[t].getFreq(r).push(s)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===r.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((t=>t.getMinValue()))));for(let t=0;t<s;++t)this.positions[t].calcPlotValue(h),this.positions[t].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),-1===this.startPosition)return;const o=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));t>=T.Layout&&((t,e,n,o)=>{b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-o*n;let a;if(this.valueAggrType===r.AGG.TOTAL_COUNT){const t=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==t&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(t)}else a=Math.max(...c().count(t).takeWhile((t=>t<=e)).map((t=>this.positions[t].sumPlotValueForHeight)));for(let i=t;i<=e;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,o):b._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);b._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(o,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const t=10*e;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${t.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(t,e,n,i,o,r,s,a){t.save();try{t.textAlign="center";let l=null,c=null;for(let e=Math.floor(s);e<=Math.floor(a);e++){const n=r[e],i=t.measureText(n.name),o=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?o:Math.max(c,o)}const h=l<i*e-2?1:(i*e-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=r[l],u=(l-s)*n*e+i*e/2,d=(o*e-c)/2;t.setTransform(h,0,0,1,u,d),t.measureText(a.label),t.fillText(a.label,0,0)}}finally{t.restore()}}(a,e,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let t=o;t<=s;t++)this.positions[t].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}b._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${t} ), end`)}}renderRequestOnDebounce(t){const e=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=T.None,this.viewSyncer.sync(e,(async()=>{await this.renderInt(t)}))):b._package.logger.warning(`${e}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const e=t.max-t.min,n=this.canvas.offsetWidth/e-this.positionMarginValue;v(n,this.positionWidth,.1)?this.render(T.Layout,"sliderOnValuesChanged"):this.getProperty(C.positionWidth)?.set(this,n)}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(T.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){b._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(T.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){if(!this.monomerLib||!this.seqHandler)return;const e=window.devicePixelRatio;try{const n=t,i=this.canvas.getCursorPosition(n,e),[s,a]=this.getMonomer(i,e),l=this.showPositionLabels?12*e:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const t=[o.divText(`Position ${s.label}`)];if(this.valueAggrType===r.AGG.TOTAL_COUNT){const e=this.seqHandler.defaultBiotype;t.push(s.buildCompositionTable(e,this.monomerLib))}const e=o.divV(t);e.style.maxHeight="80vh",o.tooltip.show(e,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=s.getFreq(a),e=[o.div(`${a}`),o.div(`${t.rowCount} rows`)];this.valueAggrType!==r.AGG.TOTAL_COUNT&&e.push(o.div(`${this.valueAggrType}: ${t.value.toFixed(3)}`));const i=o.divV(e);o.tooltip.show(i,n.x+16,n.y+16)}else o.tooltip.hide()}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,o]=this.getMonomer(this.canvas.getCursorPosition(e,n),n);if(null!==i&&null!==o&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=r.BitSet.create(this.dataFrame.selection.length,(t=>function(t,e,n,i,o,r){const s=e.getSplitted(i),a=r.pos<s.length?s.getCanonical(r.pos):null;return null!==a&&a===o}(this.dataFrame,this.seqHandler,this.getFilter(),t,o,i)));this.dataFrame.selection.init((e=>t.get(e)))}}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=p(t);b._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+e)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`invalidate(${t?` <- ${t} `:""})`,n=`${this.toLog()}.${e}`;this.render(T.None,e),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}},1687:(t,e,n)=>{"use strict";n.d(e,{_i:()=>x});var i=n(7389),o=n(6082),r=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(4954),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(6723);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(t){super(),this.seqHelper=t,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const t of this.viewSubs)t.unsubscribe()}async attach(){this.viewerToLog();try{const t=await(0,g.b2)();let e,n;this.helmEditor=t.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{e=i.div(),n=t.createWebEditorApp(e,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{try{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(t,void 0,v._package.logger)}catch(t){this.logger.error(t)}finally{f()(e).empty(),e=null,n=null}})).onCancel((()=>{f()(e).empty(),e=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((t=>{try{if(n){const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(t)}}catch(t){const[e,n]=(0,y.AP)(t);this.logger.error(e,void 0,n)}})))}catch(t){const[e,n]=(0,y.AP)(t),o=this._filterPanel;o.innerText="error",o.classList.add("d4-error"),i.tooltip.bind(o,e)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(t){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=e/2;if(t)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,n);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,t)}}async substructureSearch(t){const e=`${this.viewerToLog()}.substructureSearch( column = <${t.name}> )`;v._package.logger.debug(`${e}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,t,this.seqHelper)}finally{v._package.logger.debug(`${e}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(t,e,n,i,o){this.props=t,this.filterId=e,this.dataFrameId=n,this.columnName=i,this.bitset=o}}class S extends p.n{separator;constructor(t,e,n){super(t,!1,n),this.separator=e,this.readOnly=!0}}class x extends o.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(t,e){super(),this.seqHelper=t,this.logger=e,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(t){const e=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{e(t),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=t.columns.bySemType(o.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new T(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(o.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(r.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(r.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const t=super.detach.bind(this),e=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(e,(async()=>{for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[],t(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(t){t.filterId!==this.filterId&&t.dataFrameId===this.dataFrame.id&&t.columnName===this.columnName&&(this.bioFilter.props=t.props)}applyFilter(){const t=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${t}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=`${this.filterToLog()}.saveState()`,e=super.saveState();return this.logger.debug(`${t}, super.state = ${JSON.stringify(e)}`),e.props=this.bioFilter.saveProps(),e}applyState(t){const e=`${this.filterToLog()}.applyState()`;super.applyState(t),this.filterSyncer.sync(e,(async()=>{t.props&&this.bioFilter&&(this.bioFilter.props=o.toJs(t.props??{}))}))}fireFilterSync(){const t=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${t}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),r.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const t=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${t}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(t,(async()=>{this.calculating=!0;try{this.logger.debug(`${t}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${t}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${t}, end`)}}))}grokEventsOnResetFilterRequest(){const t=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${t}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.filterToLog()}.invalidate(${t?` <- ${t} `:""})`;this.filterSyncer.sync(e,(async()=>{this._onRendered.next()}))}async awaitRendered(t=1e4){const e=`awaitRendered( ${t} )`,n=`${this.filterToLog()}.${e}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(e)}),t,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{window.setTimeout((()=>{this.props=new p.n(t,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(t){return(0,d.nI)(this.props.substructure,t)}async attach(){}async detach(){await super.detach()}}class T extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(t){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{this.props=new S(t,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=t,onValueChanged:t=>{const e=t||"";this.props=new S(this.props.substructure,e,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const t=this.props.separator??this.colSeparator;this.separatorInput.value!==t&&(this.separatorInput.value=t)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,d.nI)(this.substructure,t,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},1757:t=>{"use strict";t.exports=$},6082:t=>{"use strict";t.exports=DG},4328:t=>{"use strict";t.exports=grok},1858:t=>{"use strict";t.exports=rxjs},9713:t=>{"use strict";t.exports=rxjs.operators},7389:t=>{"use strict";t.exports=ui},1991:t=>{"use strict";t.exports=wu},8343:(t,e,n)=>{"use 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n={host:t.host,scheme:t.scheme,userinfo:t.userinfo,port:t.port,path:t.path,query:t.query,nid:t.nid,nss:t.nss,uuid:t.uuid,fragment:t.fragment,reference:t.reference,resourceName:t.resourceName,secure:t.secure,error:""},i=Object.assign({},e),o=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&o.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&o.push("//"),o.push(c),n.path&&"/"!==n.path.charAt(0)&&o.push("/")),void 0!==n.path){let t=n.path;i.absolutePath||a&&a.absolutePath||(t=r(t)),void 0===c&&(t=t.replace(/^\/\//u,"/%2F")),o.push(t)}return void 0!==n.query&&o.push("?",n.query),void 0!==n.fragment&&o.push("#",n.fragment),o.join("")}const u=Array.from({length:127},((t,e)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(e)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(t,e){const n=Object.assign({},e),r={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==t.indexOf("%");let a=!1;"suffix"===n.reference&&(t=(n.scheme?n.scheme+":":"")+"//"+t);const c=t.match(d);if(c){if(r.scheme=c[1],r.userinfo=c[3],r.host=c[4],r.port=parseInt(c[5],10),r.path=c[6]||"",r.query=c[7],r.fragment=c[8],isNaN(r.port)&&(r.port=c[5]),r.host){const t=o(r.host);if(!1===t.isIPV4){const e=i(t.host);r.host=e.host.toLowerCase(),a=e.isIPV6}else r.host=t.host,a=!0}void 0!==r.scheme||void 0!==r.userinfo||void 0!==r.host||void 0!==r.port||void 0!==r.query||r.path?void 0===r.scheme?r.reference="relative":void 0===r.fragment?r.reference="absolute":r.reference="uri":r.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==r.reference&&(r.error=r.error||"URI is not a "+n.reference+" reference.");const t=l[(n.scheme||r.scheme||"").toLowerCase()];if(!(n.unicodeSupport||t&&t.unicodeSupport)&&r.host&&(n.domainHost||t&&t.domainHost)&&!1===a&&function(t){let e=0;for(let n=0,i=t.length;n<i;++n)if(e=t.charCodeAt(n),e>126||u[e])return!0;return!1}(r.host))try{r.host=URL.domainToASCII(r.host.toLowerCase())}catch(t){r.error=r.error||"Host's domain name can not be converted to ASCII: "+t}(!t||t&&!t.skipNormalize)&&(s&&void 0!==r.scheme&&(r.scheme=unescape(r.scheme)),s&&void 0!==r.host&&(r.host=unescape(r.host)),r.path&&(r.path=escape(unescape(r.path))),r.fragment&&(r.fragment=encodeURI(decodeURIComponent(r.fragment)))),t&&t.parse&&t.parse(r,n)}else r.error=r.error||"URI can not be parsed.";return r}const m={SCHEMES:l,normalize:function(t,e){return"string"==typeof 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